Krylov, Piotr
2017-01-01
This monograph is a comprehensive account of formal matrices, examining homological properties of modules over formal matrix rings and summarising the interplay between Morita contexts and K theory. While various special types of formal matrix rings have been studied for a long time from several points of view and appear in various textbooks, for instance to examine equivalences of module categories and to illustrate rings with one-sided non-symmetric properties, this particular class of rings has, so far, not been treated systematically. Exploring formal matrix rings of order 2 and introducing the notion of the determinant of a formal matrix over a commutative ring, this monograph further covers the Grothendieck and Whitehead groups of rings. Graduate students and researchers interested in ring theory, module theory and operator algebras will find this book particularly valuable. Containing numerous examples, Formal Matrices is a largely self-contained and accessible introduction to the topic, assuming a sol...
Indian Academy of Sciences (India)
dimensional superfields, is a clear signature of the presence of the (anti-)BRST invariance in the original. 4D theory. Keywords. Non-Abelian 1-form gauge theory; Dirac fields; (anti-)Becchi–Roucet–Stora–. Tyutin invariance; superfield formalism; ...
Denning, Peter J.
1991-01-01
The ongoing debate over the role of formalism and formal specifications in software features many speakers with diverse positions. Yet, in the end, they share the conviction that the requirements of a software system can be unambiguously specified, that acceptable software is a product demonstrably meeting the specifications, and that the design process can be carried out with little interaction between designers and users once the specification has been agreed to. This conviction is part of a larger paradigm prevalent in American management thinking, which holds that organizations are systems that can be precisely specified and optimized. This paradigm, which traces historically to the works of Frederick Taylor in the early 1900s, is no longer sufficient for organizations and software systems today. In the domain of software, a new paradigm, called user-centered design, overcomes the limitations of pure formalism. Pioneered in Scandinavia, user-centered design is spreading through Europe and is beginning to make its way into the U.S.
DEFF Research Database (Denmark)
Masses of Formal Philosophy is an outgrowth of Formal Philosophy. That book gathered the responses of some of the most prominent formal philosophers to five relatively open and broad questions initiating a discussion of metaphilosophical themes and problems surrounding the use of formal methods i...... in philosophy. Including contributions from a wide range of philosophers, Masses of Formal Philosophy contains important new responses to the original five questions.......Masses of Formal Philosophy is an outgrowth of Formal Philosophy. That book gathered the responses of some of the most prominent formal philosophers to five relatively open and broad questions initiating a discussion of metaphilosophical themes and problems surrounding the use of formal methods...
Indian Academy of Sciences (India)
by testing of the components and successful testing leads to the software being ... Formal verification is based on formal methods which are mathematically based ..... scenario under which a similar error could occur. There are various other ...
Directory of Open Access Journals (Sweden)
Douglas Walton
2015-12-01
Full Text Available This paper presents a formalization of informal logic using the Carneades Argumentation System (CAS, a formal, computational model of argument that consists of a formal model of argument graphs and audiences. Conflicts between pro and con arguments are resolved using proof standards, such as preponderance of the evidence. CAS also formalizes argumentation schemes. Schemes can be used to check whether a given argument instantiates the types of argument deemed normatively appropriate for the type of dialogue.
Pragmatics for formal semantics
DEFF Research Database (Denmark)
Danvy, Olivier
2011-01-01
This tech talk describes how to write and how to inter-derive formal semantics for sequential programming languages. The progress reported here is (1) concrete guidelines to write each formal semantics to alleviate their proof obligations, and (2) simple calculational tools to obtain a formal...
Industrial use of formal methods formal verification
Boulanger, Jean-Louis
2012-01-01
At present the literature gives students and researchers of the very general books on the formal technics. The purpose of this book is to present in a single book, a return of experience on the used of the "formal technics" (such proof and model-checking) on industrial examples for the transportation domain. This book is based on the experience of people which are completely involved in the realization and the evaluation of safety critical system software based. The implication of the industrialists allows to raise the problems of confidentiality which could appear and so allow
DEFF Research Database (Denmark)
du Gay, Paul; Lopdrup-Hjorth, Thomas
Over recent decades, institutions exhibiting high degrees of formality have come in for severe criticism. From the private to the public sector, and across a whole spectrum of actors spanning from practitioners to academics, formal organization is viewed with increasing doubt and skepticism....... In a “Schumpetarian world” (Teece et al., 1997: 509) of dynamic competition and incessant reform, formal organization appears as well suited to survival as a fish out of water. Indeed, formal organization, and its closely overlapping semantic twin bureaucracy, are not only represented as ill suited to the realities...... is that formal organization is an obstacle to be overcome. For that very reason, critics, intellectuals and reformers alike have urged public and private organizations to break out of the stifling straightjacket of formality, to dispense with bureaucracy, and to tear down hierarchies. This could either be done...
Integrating semi-formal and formal requirements
Wieringa, Roelf J.; Olivé, Antoni; Dubois, Eric; Pastor, Joan Antoni; Huyts, Sander
1997-01-01
In this paper, we report on the integration of informal, semiformal and formal requirements specification techniques. We present a framework for requirements specification called TRADE, within which several well-known semiformal specification techniques are placed. TRADE is based on an analysis of
Geometry and Formal Linguistics.
Huff, George A.
This paper presents a method of encoding geometric line-drawings in a way which allows sets of such drawings to be interpreted as formal languages. A characterization of certain geometric predicates in terms of their properties as languages is obtained, and techniques usually associated with generative grammars and formal automata are then applied…
Software Formal Inspections Guidebook
1993-01-01
The Software Formal Inspections Guidebook is designed to support the inspection process of software developed by and for NASA. This document provides information on how to implement a recommended and proven method for conducting formal inspections of NASA software. This Guidebook is a companion document to NASA Standard 2202-93, Software Formal Inspections Standard, approved April 1993, which provides the rules, procedures, and specific requirements for conducting software formal inspections. Application of the Formal Inspections Standard is optional to NASA program or project management. In cases where program or project management decide to use the formal inspections method, this Guidebook provides additional information on how to establish and implement the process. The goal of the formal inspections process as documented in the above-mentioned Standard and this Guidebook is to provide a framework and model for an inspection process that will enable the detection and elimination of defects as early as possible in the software life cycle. An ancillary aspect of the formal inspection process incorporates the collection and analysis of inspection data to effect continual improvement in the inspection process and the quality of the software subjected to the process.
DEFF Research Database (Denmark)
Garsten, Christina; Nyqvist, Anette
Ethnographic work in formal organizations involves learning to recognize the many layers of front stage and back stage of organized life, and to bracket formality. It means to be alert to the fact that what is formal and front stage for one some actors, and in some situations, may in fact be back...... stage and informal for others. Walking the talk, donning the appropriate attire, wearing the proper suit, may be part of what is takes to figure out the code of formal organizational settings – an entrance ticket to the backstage, as it were. Oftentimes, it involves a degree of mimicry, of ‘following...... suits’ (Nyqvist 2013), and of doing ‘ethnography by failure’ (Garsten 2013). In this paper, we explore the layers of informality and formality in our fieldwork experiences among financial investors and policy experts, and discuss how to ethnographically represent embodied fieldwork practices. How do we...
Necessity of Integral Formalism
International Nuclear Information System (INIS)
Tao Yong
2011-01-01
To describe the physical reality, there are two ways of constructing the dynamical equation of field, differential formalism and integral formalism. The importance of this fact is firstly emphasized by Yang in case of gauge field [Phys. Rev. Lett. 33 (1974) 445], where the fact has given rise to a deeper understanding for Aharonov-Bohm phase and magnetic monopole [Phys. Rev. D 12 (1975) 3845]. In this paper we shall point out that such a fact also holds in general wave function of matter, it may give rise to a deeper understanding for Berry phase. Most importantly, we shall prove a point that, for general wave function of matter, in the adiabatic limit, there is an intrinsic difference between its integral formalism and differential formalism. It is neglect of this difference that leads to an inconsistency of quantum adiabatic theorem pointed out by Marzlin and Sanders [Phys. Rev. Lett. 93 (2004) 160408]. It has been widely accepted that there is no physical difference of using differential operator or integral operator to construct the dynamical equation of field. Nevertheless, our study shows that the Schrödinger differential equation (i.e., differential formalism for wave function) shall lead to vanishing Berry phase and that the Schrödinger integral equation (i.e., integral formalism for wave function), in the adiabatic limit, can satisfactorily give the Berry phase. Therefore, we reach a conclusion: There are two ways of describing physical reality, differential formalism and integral formalism; but the integral formalism is a unique way of complete description. (general)
DEFF Research Database (Denmark)
Levinsen, Karin Tweddell; Sørensen, Birgitte Holm
2013-01-01
are examined and the relation between network society competences, learners’ informal learning strategies and ICT in formalized school settings over time is studied. The authors find that aspects of ICT like multimodality, intuitive interaction design and instant feedback invites an informal bricoleur approach....... When integrated into certain designs for teaching and learning, this allows for Formalized Informal Learning and support is found for network society competences building....
Integrated formal operations plan
Energy Technology Data Exchange (ETDEWEB)
Cort, G.; Dearholt, W.; Donahue, S.; Frank, J.; Perkins, B.; Tyler, R.; Wrye, J.
1994-01-05
The concept of formal operations (that is, a collection of business practices to assure effective, accountable operations) has vexed the Laboratory for many years. To date most attempts at developing such programs have been based upon rigid, compliance-based interpretations of a veritable mountain of Department of Energy (DOE) orders, directives, notices, and standards. These DOE dictates seldom take the broad view but focus on highly specialized programs isolated from the overall context of formal operations. The result is a confusing array of specific, and often contradictory, requirements that produce a patchwork of overlapping niche programs. This unnecessary duplication wastes precious resources, dramatically increases the complexity of our work processes, and communicates a sense of confusion to our customers and regulators. Coupled with the artificial divisions that have historically existed among the Laboratory`s formal operations organizations (quality assurance, configuration management, records management, training, etc.), this approach has produced layers of increasingly vague and complex formal operations plans, each of which interprets its parent and adds additional requirements of its own. Organizational gridlock ensues whenever an activity attempts to implement these bureaucratic monstrosities. The integrated formal operations plan presented is to establish a set of requirements that must be met by an integrated formal operations program, assign responsibilities for implementation and operation of the program, and specify criteria against which the performance of the program will be measured. The accountable line manager specifies the items, processes, and information (the controlled elements) to which the formal operations program specified applies. The formal operations program is implemented using a graded approach based on the level of importance of the various controlled elements and the scope of the activities in which they are involved.
Formalizing Probabilistic Safety Claims
Herencia-Zapana, Heber; Hagen, George E.; Narkawicz, Anthony J.
2011-01-01
A safety claim for a system is a statement that the system, which is subject to hazardous conditions, satisfies a given set of properties. Following work by John Rushby and Bev Littlewood, this paper presents a mathematical framework that can be used to state and formally prove probabilistic safety claims. It also enables hazardous conditions, their uncertainties, and their interactions to be integrated into the safety claim. This framework provides a formal description of the probabilistic composition of an arbitrary number of hazardous conditions and their effects on system behavior. An example is given of a probabilistic safety claim for a conflict detection algorithm for aircraft in a 2D airspace. The motivation for developing this mathematical framework is that it can be used in an automated theorem prover to formally verify safety claims.
DEFF Research Database (Denmark)
Williams, Kristine; Christensen, Jesper; Helin, Kristian
2012-01-01
DNA methylation is involved in key cellular processes, including X-chromosome inactivation, imprinting and transcriptional silencing of specific genes and repetitive elements. DNA methylation patterns are frequently perturbed in human diseases such as imprinting disorders and cancer. The recent...... discovery that the three members of the TET protein family can convert 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) has provided a potential mechanism leading to DNA demethylation. Moreover, the demonstration that TET2 is frequently mutated in haematopoietic tumours suggests that the TET...... proteins are important regulators of cellular identity. Here, we review the current knowledge regarding the function of the TET proteins, and discuss various mechanisms by which they contribute to transcriptional control. We propose that the TET proteins have an important role in regulating DNA methylation...
DEFF Research Database (Denmark)
du Gay, Paul; Lopdrup-Hjorth, Thomas
2016-01-01
term this ‘fear of the formal’, outlining key elements of its genealogy and exploring its contemporary manifestation in relation to recent and ongoing reforms of organisational life in a range of contexts. At the same time, we seek to indicate the continuing constitutive significance of formality...
Formalization of Medical Guidelines
Czech Academy of Sciences Publication Activity Database
Peleška, Jan; Anger, Z.; Buchtela, David; Šebesta, K.; Tomečková, Marie; Veselý, Arnošt; Zvára, K.; Zvárová, Jana
2005-01-01
Roč. 1, - (2005), s. 133-141 ISSN 1801-5603 R&D Projects: GA AV ČR 1ET200300413 Institutional research plan: CEZ:AV0Z10300504 Keywords : GLIF model * formalization of guidelines * prevention of cardiovascular diseases Subject RIV: IN - Informatics, Computer Science
Readings in Formal Epistemology
DEFF Research Database (Denmark)
‘Formal epistemology’ is a term coined in the late 1990s for a new constellation of interests in philosophy,the roots of which are found in earlier works of epistemologists, philosophers of science, and logicians. It addresses a growing agenda of problems concerning knowledge, belief, certainty, ...
Criteria for logical formalization
Czech Academy of Sciences Publication Activity Database
Peregrin, Jaroslav; Svoboda, Vladimír
2013-01-01
Roč. 190, č. 14 (2013), s. 2897-2924 ISSN 0039-7857 R&D Projects: GA ČR(CZ) GAP401/10/1279 Institutional support: RVO:67985955 Keywords : logic * logical form * formalization * reflective equilibrium Subject RIV: AA - Philosophy ; Religion Impact factor: 0.637, year: 2013
1991-10-01
SUBJECT TERMS 15. NUMBER OF PAGES engineering management information systems method formalization 60 information engineering process modeling 16 PRICE...CODE information systems requirements definition methods knowlede acquisition methods systems engineering 17. SECURITY CLASSIFICATION ji. SECURITY... Management , Inc., Santa Monica, California. CORYNEN, G. C., 1975, A Mathematical Theory of Modeling and Simula- tion. Ph.D. Dissertation, Department
DEFF Research Database (Denmark)
Rand, John; Torm, Nina Elisabeth
2012-01-01
Based on unique panel data consisting of both formal and informal firms, this paper uses a matched double difference approach to examine the relationship between legal status and firm level outcomes in micro, small and medium manufacturing enterprises (SMEs) in Vietnam. Controlling for determinin...
Formalizing physical security procedures
Meadows, C.; Pavlovic, Dusko
Although the problems of physical security emerged more than 10,000 years before the problems of computer security, no formal methods have been developed for them, and the solutions have been evolving slowly, mostly through social procedures. But as the traffic on physical and social networks is now
Formalizing the concept of sound.
Energy Technology Data Exchange (ETDEWEB)
Kaper, H. G.; Tipei, S.
1999-08-03
The notion of formalized music implies that a musical composition can be described in mathematical terms. In this article we explore some formal aspects of music and propose a framework for an abstract approach.
Formal Analysis of Domain Models
National Research Council Canada - National Science Library
Bharadwaj, Ramesh
2002-01-01
Recently, there has been a great deal of interest in the application of formal methods, in particular, precise formal notations and automatic analysis tools for the creation and analysis of requirements specifications (i.e...
Formalization of Database Systems -- and a Formal Definition of {IMS}
DEFF Research Database (Denmark)
Bjørner, Dines; Løvengreen, Hans Henrik
1982-01-01
Drawing upon an analogy between Programming Language Systems and Database Systems we outline the requirements that architectural specifications of database systems must futfitl, and argue that only formal, mathematical definitions may 6atisfy these. Then we illustrate home aspects and touch upon...... come ueee of formal definitions of data models and databaee management systems. A formal model of INS will carry this discussion. Finally we survey some of the exkting literature on formal definitions of database systems. The emphasis will be on constructive definitions in the denotationul semantics...... style of the VCM: Vienna Development Nethd. The role of formal definitions in international standardiaation efforts is briefly mentioned....
Topical Roots of Formal Dialectic
Krabbe, Erik C. W.
Formal dialectic has its roots in ancient dialectic. We can trace this influence in Charles Hamblin's book on fallacies, in which he introduced his first formal dialectical systems. Earlier, Paul Lorenzen proposed systems of dialogical logic, which were in fact formal dialectical systems avant la
Directory of Open Access Journals (Sweden)
Diana-Maria Drigă
2015-12-01
Full Text Available The concept of resilience has represented during the recent years a leading concern both in Romania, within the European Union and worldwide. Specialists in economics, management, finance, legal sciences, political sciences, sociology, psychology, grant a particular interest to this concept. Multidisciplinary research of resilience has materialized throughout the time in multiple conceptualizations and theorizing, but without being a consensus between specialists in terms of content, specificity and scope. Through this paper it is intended to clarify the concept of resilience, achieving an exploration of the evolution of this concept in ecological, social and economic environment. At the same time, the paper presents aspects of feedback mechanisms and proposes a formalization of resilience using the logic and mathematical analysis.
DEFF Research Database (Denmark)
Levinsen, Karin; Sørensen, Birgitte Holm
2011-01-01
and other relevant stakeholders, as well as participant observations in the classroom documented by thick descriptions, formal and informal interviews and focus group interviews. The aim of the study was to explore and identify relations between designs for teaching and learning and the students' learning......This paper presents findings from a large-scale longitudinal, qualitative study - Project ICT and Learning (PIL) - that engaged the participation of eight primary schools in Denmark, and was conducted between 2006 and 2008. The research design was based on action research, involving teachers...... of school subjects within defined learning goals and curricula, along with various implementations of ICT in the pedagogical everyday practice (Levinsen & Sørensen 2008). However, another research strand - the topic of this paper - emerged during the project's life cycle as a consequence of ongoing changes...
Spinor formalism and complex-vector formalism of general relativity
International Nuclear Information System (INIS)
Han-ying, G.; Yong-shi, W.; Gendao, L.
1974-01-01
In this paper, using E. Cartan's exterior calculus, we give the spinor form of the structure equations, which leads naturally to the Newman--Penrose equations. Furthermore, starting from the spinor spaces and the el (2C) algebra, we construct the general complex-vector formalism of general relativity. We find that both the Cahen--Debever--Defrise complex-vector formalism and that of Brans are its special cases. Thus, the spinor formalism and the complex-vector formalism of general relativity are unified on the basis of the uni-modular group SL(2C) and its Lie algebra
Formal System Verification - Extension 2
2012-08-08
vision of truly trustworthy systems has been to provide a formally verified microkernel basis. We have previously developed the seL4 microkernel...together with a formal proof (in the theorem prover Isabelle/HOL) of its functional correctness [6]. This means that all the behaviours of the seL4 C...source code are included in the high-level, formal specification of the kernel. This work enabled us to provide further formal guarantees about seL4 , in
Formalized Epistemology, Logic, and Grammar
Bitbol, Michel
The task of a formal epistemology is defined. It appears that a formal epistemology must be a generalization of "logic" in the sense of Wittgenstein's Tractatus. The generalization is required because, whereas logic presupposes a strict relation between activity and language, this relation may be broken in some domains of experimental enquiry (e.g., in microscopic physics). However, a formal epistemology should also retain a major feature of Wittgenstein's "logic": It must not be a discourse about scientific knowledge, but rather a way of making manifest the structures usually implicit in knowledge-gaining activity. This strategy is applied to the formalism of quantum mechanics.
Formal, Non-Formal and Informal Learning in the Sciences
Ainsworth, Heather L.; Eaton, Sarah Elaine
2010-01-01
This research report investigates the links between formal, non-formal and informal learning and the differences between them. In particular, the report aims to link these notions of learning to the field of sciences and engineering in Canada and the United States, including professional development of adults working in these fields. It offers…
DEFF Research Database (Denmark)
Bjørner, Dines; Havelund, Klaus
2014-01-01
In this "40 years of formal methods" essay we shall first delineate, Sect. 1, what we mean by method, formal method, computer science, computing science, software engineering, and model-oriented and algebraic methods. Based on this, we shall characterize a spectrum from specification-oriented met...
Leibniz' First Formalization of Syllogistics
DEFF Research Database (Denmark)
Robering, Klaus
2014-01-01
of letters just those which belong to the useful, i.e., valid, modes. The set of codes of valid modes turns out to be a so-called "regular" language (in the sense of formal-language-theory). Leibniz' formalization of syllogistics in his Dissertatio thus contains an estimation of the computational complexity...
Seniority in projection operator formalism
International Nuclear Information System (INIS)
Ullah, N.
1976-01-01
It is shown that the concept of seniority can be introduced in projection operator formalism through the use of the operator Q, which has been defined by de-Shalit and Talmi. The usefulness of seniority concept in projection operator formalism is discussed. An example of four nucleons in j=3/2 configuration is given for illustrative purposes
A Formalization of Linkage Analysis
DEFF Research Database (Denmark)
Ingolfsdottir, Anna; Christensen, A.I.; Hansen, Jens A.
In this report a formalization of genetic linkage analysis is introduced. Linkage analysis is a computationally hard biomathematical method, which purpose is to locate genes on the human genome. It is rooted in the new area of bioinformatics and no formalization of the method has previously been ...
New procedure for departure formalities
HR & GS Departments
2011-01-01
As part of the process of simplifying procedures and rationalising administrative processes, the HR and GS Departments have introduced new personalised departure formalities on EDH. These new formalities have applied to students leaving CERN since last year and from 17 October 2011 this procedure will be extended to the following categories of CERN personnel: Staff members, Fellows and Associates. It is planned to extend this electronic procedure to the users in due course. What purpose do departure formalities serve? The departure formalities are designed to ensure that members of the personnel contact all the relevant services in order to return any necessary items (equipment, cards, keys, dosimeter, electronic equipment, books, etc.) and are aware of all the benefits to which they are entitled on termination of their contract. The new departure formalities on EDH have the advantage of tailoring the list of services that each member of the personnel must visit to suit his individual contractual and p...
Formal verification - Robust and efficient code: Introduction to Formal Verification
CERN. Geneva
2016-01-01
In general, FV means "proving that certain properties hold for a given system using formal mathematics". This definition can certainly feel daunting, however, as we will learn, we can reap benefits from the paradigm without digging too deep into ...
Scalable Techniques for Formal Verification
Ray, Sandip
2010-01-01
This book presents state-of-the-art approaches to formal verification techniques to seamlessly integrate different formal verification methods within a single logical foundation. It should benefit researchers and practitioners looking to get a broad overview of the spectrum of formal verification techniques, as well as approaches to combining such techniques within a single framework. Coverage includes a range of case studies showing how such combination is fruitful in developing a scalable verification methodology for industrial designs. This book outlines both theoretical and practical issue
El Salvador - Formal Technical Education
Millennium Challenge Corporation — With a budget of nearly $20 million, the Formal Technical Education Sub-Activity was designed to strengthen technical and vocational educational institutions in the...
Concepts of formal concept analysis
Žáček, Martin; Homola, Dan; Miarka, Rostislav
2017-07-01
The aim of this article is apply of Formal Concept Analysis on concept of world. Formal concept analysis (FCA) as a methodology of data analysis, information management and knowledge representation has potential to be applied to a verity of linguistic problems. FCA is mathematical theory for concepts and concept hierarchies that reflects an understanding of concept. Formal concept analysis explicitly formalizes extension and intension of a concept, their mutual relationships. A distinguishing feature of FCA is an inherent integration of three components of conceptual processing of data and knowledge, namely, the discovery and reasoning with concepts in data, discovery and reasoning with dependencies in data, and visualization of data, concepts, and dependencies with folding/unfolding capabilities.
Helicity formalism and spin effects
International Nuclear Information System (INIS)
Anselmino, M.; Caruso, F.; Piovano, U.
1990-01-01
The helicity formalism and the technique to compute amplitudes for interaction processes involving leptons, quarks, photons and gluons are reviewed. Explicit calculations and examples of exploitation of symmetry properties are shown. The formalism is then applied to the discussion of several hadronic processes and spin effects: the experimental data, when related to the properties of the elementary constituent interactions, show many not understood features. Also the nucleon spin problem is briefly reviewed. (author)
Dissociation dynamics of methylal
Energy Technology Data Exchange (ETDEWEB)
Beaud, P; Frey, H -M; Gerber, T; Mischler, B; Radi, P P; Tzannis, A -P [Paul Scherrer Inst. (PSI), Villigen (Switzerland)
1999-08-01
The dissociation of methylal is investigated using mass spectrometry, combined with a pyrolytic radical source and femtosecond pump probe experiments. Based on preliminary results two reaction paths of methylal dissociation are proposed and discussed. (author) 4 fig., 3 refs.
International Nuclear Information System (INIS)
Sahraoui, Lakhdar; Khimeche, Kamel; Dahmani, Abdallah; Mokbel, Ilham; Jose, Jacques
2016-01-01
Highlight: • Vapor-liquid equilibria, Enthalpy of Vaporization, saturated Fatty Acid Methyl Ester. - Abstract: Vapor pressures of six saturated Fatty Acid Methyl Esters (FAMEs), methyl hexanoate (or methyl caproate), methyl octanoate (or methyl caprylate), Methyl decanoate (or methyl caprate), methyl dodecanoate (or methyl laurate), methyl tetradecanoate (or methyl myristate), and methyl hexadecanoate (or methyl palmitate) were measured from 1 Pa to 100 kPa and at temperature range between 262 and 453 K using a static apparatus. The experimental data (P-T) were compared with the available literature data.
DEFF Research Database (Denmark)
Villesèche, Florence; Josserand, Emmanuel
2017-01-01
/organisations and the wider social group of women in business. Research limitations/implications: The authors focus on the distinction between external and internal formal women-only networks while also acknowledging the broader diversity that can characterise such networks. Their review provides the reader with an insight...... member level, the authors suggest that such networks can be of value for organisations and the wider social group of women in management and leadership positions.......Purpose: The purpose of this paper is to review the emerging literature on formal women-only business networks and outline propositions to develop this under-theorised area of knowledge and stimulate future research. Design/methodology/approach: The authors review the existing literature on formal...
Informal work and formal plans
DEFF Research Database (Denmark)
Dalsted, Rikke Juul; Hølge-Hazelton, Bibi; Kousgaard, Marius Brostrøm
2012-01-01
INTRODUCTION: Formal pathways models outline that patients should receive information in order to experience a coherent journey but do not describe an active role for patients or their relatives. The aim of this is paper is to articulate and discuss the active role of patients during their cancer...... trajectories. METHODS AND THEORY: An in-depth case study of patient trajectories at a Danish hospital and surrounding municipality using individual interviews with patients. Theory about trajectory and work by Strauss was included. RESULTS: Patients continuously took initiatives to organize their treatment....... The patients' requests were not sufficiently supported in the professional organisation of work or formal planning. Patients' insertion and use of information in their trajectories challenged professional views and working processes. And the design of the formal pathway models limits the patients' active...
The role of formal specifications
International Nuclear Information System (INIS)
McHugh, J.
1994-01-01
The role of formal requirements specification is discussed under the premise that the primary purpose of such specifications is to facilitate clear and unambiguous communications among the communities of interest for a given project. An example is presented in which the failure to reach such an understanding resulted in an accident at a chemical plant. Following the example, specification languages based on logical formalisms and notations are considered. These are rejected as failing to serve the communications needs of diverse communities. The notion of a specification as a surrogate for a program is also considered and rejected. The paper ends with a discussion of the type of formal notation that will serve the communications role and several encouraging developments are noted
Formal connections in deformation quantization
DEFF Research Database (Denmark)
Masulli, Paolo
The field of this thesis is deformation quantization, and we consider mainly symplectic manifolds equipped with a star product. After reviewing basics in complex geometry, we introduce quantization, focusing on geometric quantization and deformation quantization. The latter is defined as a star...... characteristic class, and that formal connections form an affine space over the derivations of the star products. Moreover, if the parameter space for the family of star products is contractible, we obtain that any two flat formal connections are gauge equivalent via a self-equivalence of the family of star...
Formal systems for persuasion dialogue
Prakken, Henry
This article reviews formal systems that regulate persuasion dialogues. In such dialogues two or more participants aim to resolve a difference of opinion, each trying to persuade the other participants to adopt their point of view. Systems for persuasion dialogue have found application in various
Charging transient in polyvinyl formal
Indian Academy of Sciences (India)
Unknown
401–406. © Indian Academy of Sciences. 401. Charging transient in polyvinyl formal. P K KHARE*, P L JAIN† and R K PANDEY‡. Department of Postgraduate Studies & Research in Physics & Electronics, Rani Durgavati University,. Jabalpur 482 001, India. †Department of Physics, Government PG College, Damoh 470 ...
A formalization of computational trust
Güven - Ozcelebi, C.; Holenderski, M.J.; Ozcelebi, T.; Lukkien, J.J.
2018-01-01
Computational trust aims to quantify trust and is studied by many disciplines including computer science, social sciences and business science. We propose a formal computational trust model, including its parameters and operations on these parameters, as well as a step by step guide to compute trust
Formal monkey linguistics : The debate
Schlenker, Philippe; Chemla, Emmanuel; Schel, Anne M.|info:eu-repo/dai/nl/413333450; Fuller, James; Gautier, Jean Pierre; Kuhn, Jeremy; Veselinović, Dunja; Arnold, Kate; Cäsar, Cristiane; Keenan, Sumir; Lemasson, Alban; Ouattara, Karim; Ryder, Robin; Zuberbühler, Klaus
2016-01-01
We explain why general techniques from formal linguistics can and should be applied to the analysis of monkey communication - in the areas of syntax and especially semantics. An informed look at our recent proposals shows that such techniques needn't rely excessively on categories of human language:
Rotor and wind turbine formalism
DEFF Research Database (Denmark)
Branlard, Emmanuel Simon Pierre
2017-01-01
The main conventions used in this book for the study of rotors are introduced in this chapter. The main assumptions and notations are provided. The formalism specific to wind turbines is presented. The forces, moments, velocities and dimensionless coefficients used in the study of rotors...
Automatic Testing with Formal Methods
Tretmans, G.J.; Belinfante, Axel
1999-01-01
The use of formal system specifications makes it possible to automate the derivation of test cases from specifications. This allows to automate the whole testing process, not only the test execution part of it. This paper presents the state of the art and future perspectives in testing based on
Formal Methods: Practice and Experience
DEFF Research Database (Denmark)
Woodcock, Jim; Larsen, Peter Gorm; Bicarregui, Juan
2009-01-01
. Based on this, we discuss the issues surrounding the industrial adoption of formal methods. Finally, we look to the future and describe the development of a Verified Software Repository, part of the worldwide Verified Software Initiative. We introduce the initial projects being used to populate...... the repository, and describe the challenges they address. © 2009 ACM. (146 refs.)...
Critical formalism or digital biomorphology. The contemporary architecture formal dilema
Directory of Open Access Journals (Sweden)
Beatriz Villanueva Cajide
2018-05-01
Full Text Available With the dawn of digital media the architecture’s formal possibilities reached a level unknown before. The Guggenheim Museo branch in Bilbao appears in 1993 as the materialisation of the possibilities of the use of digital tools in architecture’s design, starting the development of a digital based architecture which currently has reached an exhaustion level that is evident in the repetition biomorphologic shapes emerged from the digital determinism to which some contemporary architectural practices have converged. While the digitalisation of the architectural process is irreversible and desirable, it is necessary to rethink the terms of this collaboration beyond the possibilities of the digital tools themselves. This article proposes to analyse seven texts written in the very moment when digitalisation became a real possibility, between Gehry’s conception of the Guggenheim Museum in 1992 and the Congress on Morphogenesis hold in the Architectural Association in 2004, in order to explore the possibility of reversing the process that has led to the formal exhaustion of digital architecture, from the acceptance of incorporating strategies coming from a contemporary critical formalism.
Formal Institutions and Subjective Wellbeing
DEFF Research Database (Denmark)
Bjørnskov, Christian; Dreher, Axel; Fischer, Justina A.V.
2010-01-01
A long tradition in economics explores the association between the quality of formal institutions and economic performance. The literature on the relationship between such institutions and happiness is, however, rather limited, and inconclusive. In this paper, we revisit the findings from recent...... cross-country studies on the institution-happiness association. Our findings suggest that their conclusions are qualitatively rather insensitive to the specific measure of 'happiness' used, while the associations between formal institutions and subjective well-being differ among poor and rich countries....... Separating different types of institutional quality, we find that in low-income countries the effects of economic-judicial institutions on happiness dominate those of political institutions, while analyses restricted to middle- and high-income countries show strong support for an additional beneficial effect...
Contextual approach to quantum formalism
Khrennikov, Andrei
2009-01-01
The aim of this book is to show that the probabilistic formalisms of classical statistical mechanics and quantum mechanics can be unified on the basis of a general contextual probabilistic model. By taking into account the dependence of (classical) probabilities on contexts (i.e. complexes of physical conditions), one can reproduce all distinct features of quantum probabilities such as the interference of probabilities and the violation of Bell’s inequality. Moreover, by starting with a formula for the interference of probabilities (which generalizes the well known classical formula of total probability), one can construct the representation of contextual probabilities by complex probability amplitudes or, in the abstract formalism, by normalized vectors of the complex Hilbert space or its hyperbolic generalization. Thus the Hilbert space representation of probabilities can be naturally derived from classical probabilistic assumptions. An important chapter of the book critically reviews known no-go theorems...
Informal work and formal plans
DEFF Research Database (Denmark)
Dalsted, Rikke Juul; Hølge-Hazelton, Bibi; Kousgaard, Marius Brostrøm
2012-01-01
trajectories. METHODS AND THEORY: An in-depth case study of patient trajectories at a Danish hospital and surrounding municipality using individual interviews with patients. Theory about trajectory and work by Strauss was included. RESULTS: Patients continuously took initiatives to organize their treatment...... and care. They initiated processes in the trajectories, and acquired information, which they used to form their trajectories. Patients presented problems to the healthcare professionals in order to get proper help when needed. DISCUSSION: Work done by patients was invisible and not perceived as work....... The patients' requests were not sufficiently supported in the professional organisation of work or formal planning. Patients' insertion and use of information in their trajectories challenged professional views and working processes. And the design of the formal pathway models limits the patients' active...
Polynomials formalism of quantum numbers
International Nuclear Information System (INIS)
Kazakov, K.V.
2005-01-01
Theoretical aspects of the recently suggested perturbation formalism based on the method of quantum number polynomials are considered in the context of the general anharmonicity problem. Using a biatomic molecule by way of example, it is demonstrated how the theory can be extrapolated to the case of vibrational-rotational interactions. As a result, an exact expression for the first coefficient of the Herman-Wallis factor is derived. In addition, the basic notions of the formalism are phenomenologically generalized and expanded to the problem of spin interaction. The concept of magneto-optical anharmonicity is introduced. As a consequence, an exact analogy is drawn with the well-known electro-optical theory of molecules, and a nonlinear dependence of the magnetic dipole moment of the system on the spin and wave variables is established [ru
Methodology of formal software evaluation
International Nuclear Information System (INIS)
Tuszynski, J.
1998-01-01
Sydkraft AB, the major Swedish utility, owner of ca 6000 MW el installed in nuclear (NPP Barsebaeck and NPP Oskarshamn), fossil fuel and hydro Power Plants is facing modernization of the control systems of the plants. Standards applicable require structured, formal methods for implementation of the control functions in the modem, real time software systems. This presentation introduces implementation methodology as discussed presently at the Sydkraft organisation. The approach suggested is based upon the process of co-operation of three parties taking part in the implementation; owner of the plant, vendor and Quality Assurance (QA) organisation. QA will be based on tools for formal software validation and on systematic gathering by the owner of validated and proved-by-operation control modules for the concern-wide utilisation. (author)
Stroh formalism and Rayleigh waves
Tanuma, Kazumi
2008-01-01
Introduces a powerful and elegant mathematical method for the analysis of anisotropic elasticity equationsThe reader can grasp the essentials as quickly as possibleCan be used as a textbook, which presents compactly introduction and applications of the Stroh formalismAppeals to the people not only in mathematics but also in mechanics and engineering sciencePrerequisites are only basic linear algebra, calculus and fundamentals of differential equations
Variational formalism for spin particles
International Nuclear Information System (INIS)
Horvathy, P.
1977-11-01
The geometrical formulation of Hamilton's principle presented in a previous paper has been related to the usual one in terms of Lagrangian functions. The exact conditions for their equivalence are obtained and a method is given for the construction of a Lagrangian function. The formalism is extended to spin particles and a local Lagrangian is constructed in this case, too. However, this function cannot be extended to a global one. (D.P.)
Review of the helicity formalism
International Nuclear Information System (INIS)
Barreiro, F.; Cerrada, M.; Fernandez, E.
1972-01-01
Our purpose in these notes has been to present a brief and general review of the helicity formalism. We begin by discussing Lorentz invariance, spin and helicity ideas, in section 1 . In section 2 we deal with the construction of relativistic states and scattering amplitudes in the helicity basis and we study their transformation properties under discrete symmetries. Finally we present some more sophisticated topics like kinematical singularities of helicity amplitudes, kinematical constraints and crossing relations 3, 4, 5 respectively. (Author) 8 refs
Ashtekar formalism with real variables
International Nuclear Information System (INIS)
Kalau, W.; Nationaal Inst. voor Kernfysica en Hoge-Energiefysica
1990-12-01
A new approach to canonical gravity is presented which is based on the Ashtekar formalism. But, in contrast to Ashtekar's variables, this formulation does not need complex quantities nor does it lead to second class constraints. This is achieved using SO(3,1) as a gauge group instead of complexified SO(3). Because of the larger group additional first class constraints are needed which turn out to be cubic and quartic in the momenta. (author). 13 refs
Whole-genome methylation caller designed for methyl- DNA ...
African Journals Online (AJOL)
etchie
2013-02-20
Feb 20, 2013 ... Our method uses a single-CpG-resolution, whole-genome methylation ... Key words: Methyl-DNA immunoprecipitation, next-generation sequencing, ...... methylation is prevalent in embryonic stem cells andmaybe mediated.
Methylation pathways in schizophrenia
International Nuclear Information System (INIS)
Sargent, T.W. III.
1982-01-01
Research on the biochemical causes of human psychosis concentrates on investigating whether schizophremia is linked to abnormalities in the metabolism of methyl carbon groups in the body. The metabolism of C-14 labeled methyl groups in methionine is studied in animals, normal subjects and patient volunteers
Methyl-Analyzer--whole genome DNA methylation profiling.
Xin, Yurong; Ge, Yongchao; Haghighi, Fatemeh G
2011-08-15
Methyl-Analyzer is a python package that analyzes genome-wide DNA methylation data produced by the Methyl-MAPS (methylation mapping analysis by paired-end sequencing) method. Methyl-MAPS is an enzymatic-based method that uses both methylation-sensitive and -dependent enzymes covering >80% of CpG dinucleotides within mammalian genomes. It combines enzymatic-based approaches with high-throughput next-generation sequencing technology to provide whole genome DNA methylation profiles. Methyl-Analyzer processes and integrates sequencing reads from methylated and unmethylated compartments and estimates CpG methylation probabilities at single base resolution. Methyl-Analyzer is available at http://github.com/epigenomics/methylmaps. Sample dataset is available for download at http://epigenomicspub.columbia.edu/methylanalyzer_data.html. fgh3@columbia.edu Supplementary data are available at Bioinformatics online.
Formal Verification of Continuous Systems
DEFF Research Database (Denmark)
Sloth, Christoffer
2012-01-01
and the verification procedures should be algorithmically synthesizable. Autonomous control plays an important role in many safety-critical systems. This implies that a malfunction in the control system can have catastrophic consequences, e.g., in space applications where a design flaw can result in large economic...... losses. Furthermore, a malfunction in the control system of a surgical robot may cause death of patients. The previous examples involve complex systems that are required to operate according to complex specifications. The systems cannot be formally verified by modern verification techniques, due...
Measuring the effect of formalization
International Nuclear Information System (INIS)
Stoelen, K.; Mohn, P.
1998-01-01
We present an ongoing research activity concerned with measuring the effect of an increased level of formalization in software development. We summarize the experiences from a first experimental development. Based on these experiences, we discuss a number of technical issues; in particular, problems connected to metrics based on fault reports. First of all, what is a fault? Secondly, how should the fault counting be integrated in the development process? Thirdly, any reasonable definition of fault depends on a notion of satisfaction. Hence, we must address the question: What does it mean for a specification or an implementation to satisfy a requirement imposed by a more high-level specification? (author)
Formalization in Component Based Development
DEFF Research Database (Denmark)
Holmegaard, Jens Peter; Knudsen, John; Makowski, Piotr
2006-01-01
We present a unifying conceptual framework for components, component interfaces, contracts and composition of components by focusing on the collection of properties or qualities that they must share. A specific property, such as signature, functionality behaviour or timing is an aspect. Each aspect...... may be specified in a formal language convenient for its purpose and, in principle, unrelated to languages for other aspects. Each aspect forms its own semantic domain, although a semantic domain may be parameterized by values derived from other aspects. The proposed conceptual framework is introduced...
Asymmetric Formal Synthesis of Azadirachtin.
Mori, Naoki; Kitahara, Takeshi; Mori, Kenji; Watanabe, Hidenori
2015-12-01
An asymmetric formal synthesis of azadirachtin, a potent insect antifeedant, was accomplished in 30 steps to Ley's synthetic intermediate (longest linear sequence). The synthesis features: 1) rapid access to the optically active right-hand segment starting from the known 5-hydroxymethyl-2-cyclopentenone scaffold; 2) construction of the B and E rings by a key intramolecular tandem radical cyclization; 3) formation of the hemiacetal moiety in the C ring through the α-oxidation of the six-membered lactone followed by methanolysis. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Zharinov, V. V.
2013-02-01
We propose a formal construction generalizing the classic de Rham complex to a wide class of models in mathematical physics and analysis. The presentation is divided into a sequence of definitions and elementary, easily verified statements; proofs are therefore given only in the key case. Linear operations are everywhere performed over a fixed number field {F} = {R},{C}. All linear spaces, algebras, and modules, although not stipulated explicitly, are by definition or by construction endowed with natural locally convex topologies, and their morphisms are continuous.
Psychologist in non-formal education
Pavićević Miljana S.
2011-01-01
Learning is not limited to school time. It starts at birth and continues throughout the entire life. Equally important as formal education there are also non-formal and informal education. Any kind of learning outside the traditional school can be called informal. However, it is not easy to define non-formal education because it is being described differently, for example as an education movement, process, system… Projects and programs implemented under the name of non-formal education are of...
A survey of formal languages for contracts
DEFF Research Database (Denmark)
Hvitved, Tom
2010-01-01
In this short paper we present the current status on formal languages and models for contracts. By a formal model is meant an unambiguous and rigorous representation of contracts, in order to enable their automatic validation, execution, and analysis — activates that are collectively referred...... to as contract lifecycle management (CLM). We present a set of formalism requirements, which represent features that any ideal contract model should support, based on which we present a comparative survey of existing contract formalisms....
Formal Proofs for Nonlinear Optimization
Directory of Open Access Journals (Sweden)
Victor Magron
2015-01-01
Full Text Available We present a formally verified global optimization framework. Given a semialgebraic or transcendental function f and a compact semialgebraic domain K, we use the nonlinear maxplus template approximation algorithm to provide a certified lower bound of f over K.This method allows to bound in a modular way some of the constituents of f by suprema of quadratic forms with a well chosen curvature. Thus, we reduce the initial goal to a hierarchy of semialgebraic optimization problems, solved by sums of squares relaxations. Our implementation tool interleaves semialgebraic approximations with sums of squares witnesses to form certificates. It is interfaced with Coq and thus benefits from the trusted arithmetic available inside the proof assistant. This feature is used to produce, from the certificates, both valid underestimators and lower bounds for each approximated constituent.The application range for such a tool is widespread; for instance Hales' proof of Kepler's conjecture yields thousands of multivariate transcendental inequalities. We illustrate the performance of our formal framework on some of these inequalities as well as on examples from the global optimization literature.
Canonical formalism for relativistic dynamics
International Nuclear Information System (INIS)
Penafiel-Nava, V.M.
1982-01-01
The possibility of a canonical formalism appropriate for a dynamical theory of isolated relativistic multiparticle systems involving scalar interactions is studied. It is shown that a single time-parameter structure satisfying the requirements of Poincare invariance and simultaneity of the constituents (global tranversality) can not be derived from a homogeneous Lagrangian. The dynamics is deduced initially from a non-homogeneous but singular Lagrangian designed to accommodate the global tranversality constraints with the equaltime plane associated to the total momentum of the system. An equivalent standard Lagrangian is used to generalize the parametrization procedure which is referred to an arbitrary geodesic in Minkowski space. The equations of motion and the definition of center of momentum are invariant with respect to the choice of geodesic and the entire formalism becomes separable. In the original 8N-dimensional phase-space, the symmetries of the Lagrangian give rise to a canonical realization of a fifteen-generator Lie algebra which is projected in the 6N dimensional hypersurface of dynamical motions. The time-component of the total momentum is thus reduced to a neutral element and the canonical Hamiltonian survives as the only generator for time-translations so that the no-interaction theorem becomes inapplicable
Formal analysis of design process dynamics
Bosse, T.; Jonker, C.M.; Treur, J.
2010-01-01
This paper presents a formal analysis of design process dynamics. Such a formal analysis is a prerequisite to come to a formal theory of design and for the development of automated support for the dynamics of design processes. The analysis was geared toward the identification of dynamic design
Formal Analysis of Design Process Dynamics
Bosse, T.; Jonker, C.M.; Treur, J.
2010-01-01
This paper presents a formal analysis of design process dynamics. Such a formal analysis is a prerequisite to come to a formal theory of design and for the development of automated support for the dynamics of design processes. The analysis was geared toward the identification of dynamic design
Formal Symplectic Groupoid of a Deformation Quantization
Karabegov, Alexander V.
2005-08-01
We give a self-contained algebraic description of a formal symplectic groupoid over a Poisson manifold M. To each natural star product on M we then associate a canonical formal symplectic groupoid over M. Finally, we construct a unique formal symplectic groupoid ‘with separation of variables’ over an arbitrary Kähler-Poisson manifold.
Formalizing the concept phase of product development
Schuts, M.; Hooman, J.
2015-01-01
We discuss the use of formal techniques to improve the concept phase of product realisation. As an industrial application, a new concept of interventional X-ray systems has been formalized, using model checking techniques and the simulation of formal models. cop. Springer International Publishing
Formal Testing of Correspondence Carrying Software
Bujorianu, M.C.; Bujorianu, L.M.; Maharaj, S.
2008-01-01
Nowadays formal software development is characterised by use of multitude formal specification languages. Test case generation from formal specifications depends in general on a specific language, and, moreover, there are competing methods for each language. There is a need for a generic approach to
Lifelong Learning to Empowerment: Beyond Formal Education
Carr, Alexis; Balasubramanian, K.; Atieno, Rosemary; Onyango, James
2018-01-01
This paper discusses the relevance of lifelong learning vis-à-vis the Sustainable Development Goals (SDGs) and stresses the need for an approach blending formal education, non-formal and informal learning. The role of Open and Distance Learning (ODL) in moving beyond formal education and the importance of integrating pedagogy, andragogy and…
Formal modeling of virtual machines
Cremers, A. B.; Hibbard, T. N.
1978-01-01
Systematic software design can be based on the development of a 'hierarchy of virtual machines', each representing a 'level of abstraction' of the design process. The reported investigation presents the concept of 'data space' as a formal model for virtual machines. The presented model of a data space combines the notions of data type and mathematical machine to express the close interaction between data and control structures which takes place in a virtual machine. One of the main objectives of the investigation is to show that control-independent data type implementation is only of limited usefulness as an isolated tool of program development, and that the representation of data is generally dictated by the control context of a virtual machine. As a second objective, a better understanding is to be developed of virtual machine state structures than was heretofore provided by the view of the state space as a Cartesian product.
A Formal Calculus for Categories
DEFF Research Database (Denmark)
Cáccamo, Mario José
This dissertation studies the logic underlying category theory. In particular we present a formal calculus for reasoning about universal properties. The aim is to systematise judgements about functoriality and naturality central to categorical reasoning. The calculus is based on a language which...... extends the typed lambda calculus with new binders to represent universal constructions. The types of the languages are interpreted as locally small categories and the expressions represent functors. The logic supports a syntactic treatment of universality and duality. Contravariance requires a definition...... of universality generous enough to deal with functors of mixed variance. Ends generalise limits to cover these kinds of functors and moreover provide the basis for a very convenient algebraic manipulation of expressions. The equational theory of the lambda calculus is extended with new rules for the definitions...
Formal analysis of physical theories
International Nuclear Information System (INIS)
Dalla Chiara, M.L.; Toraldo di Francia, G.
1979-01-01
The rules of inference that are made use of in formalization are considered. It is maintained that a physical law represents the universal assertion of a probability, and not the assessment of the probability of a universal assertion. The precision of the apparatus used to collect the experimental evidence is introduced as an essential part of the theoretical structure of physics. This approach allows the author to define the concept of truth in a satisfactory way, abandoning the unacceptable notion of approximate truth. It is shown that a considerable amount of light can be shed on a number of much debated problems arising in the logic of quantum mechanics. It is stressed that the deductive structure of quantum theory seems to be essentially founded on a kind of mixture of different logics. Two different concepts of truth are distinguished within quantum theory, an empirical truth and quantum-logical truth. (Auth.)
Schwier, Richard A.; Seaton, J. X.
2013-01-01
Does learner participation vary depending on the learning context? Are there characteristic features of participation evident in formal, non-formal, and informal online learning environments? Six online learning environments were chosen as epitomes of formal, non-formal, and informal learning contexts and compared. Transcripts of online…
Applications of the Decoherence Formalism
Brun, Todd Andrew
In this work the decoherence formalism of quantum mechanics is explored and applied to a number of interesting problems in quantum physics. The boundary between quantum and classical physics is examined, and demonstration made that quantum histories corresponding to classical equations of motion become more probable for a broad class of models, including linear and nonlinear models of Brownian motion. The link between noise, dissipation, and decoherence is studied. This work is then applied to systems which classically exhibit dissipative chaotic dynamics. A theory is explicated for treating these systems, and the ideas are applied to a particular model of the forced, damped Duffing oscillator, which is chaotic for certain parameter values. Differences between classical and quantum chaos are examined, particularly differences arising in the structure of fractal strange attractors, and the conceptual difficulties in framing standard notions of chaos in a quantum system. A brief discussion of previous work on quantum chaos is included, and the differences between Hamiltonian and dissipative chaos pointed out; a somewhat different interpretation of quantum chaos from the standard one is suggested. A class of histories for quantum systems, in phase space rather than configuration space, is studied. Different ways of representing projections in phase space are discussed, and expressions for the probability of phase space histories are derived; conditions for such histories to decohere are also estimated in the semiclassical limit.
Quantum formalism for classical statistics
Wetterich, C.
2018-06-01
In static classical statistical systems the problem of information transport from a boundary to the bulk finds a simple description in terms of wave functions or density matrices. While the transfer matrix formalism is a type of Heisenberg picture for this problem, we develop here the associated Schrödinger picture that keeps track of the local probabilistic information. The transport of the probabilistic information between neighboring hypersurfaces obeys a linear evolution equation, and therefore the superposition principle for the possible solutions. Operators are associated to local observables, with rules for the computation of expectation values similar to quantum mechanics. We discuss how non-commutativity naturally arises in this setting. Also other features characteristic of quantum mechanics, such as complex structure, change of basis or symmetry transformations, can be found in classical statistics once formulated in terms of wave functions or density matrices. We construct for every quantum system an equivalent classical statistical system, such that time in quantum mechanics corresponds to the location of hypersurfaces in the classical probabilistic ensemble. For suitable choices of local observables in the classical statistical system one can, in principle, compute all expectation values and correlations of observables in the quantum system from the local probabilistic information of the associated classical statistical system. Realizing a static memory material as a quantum simulator for a given quantum system is not a matter of principle, but rather of practical simplicity.
Identification of Differentially Methylated Sites with Weak Methylation Effects
Directory of Open Access Journals (Sweden)
Hong Tran
2018-02-01
Full Text Available Deoxyribonucleic acid (DNA methylation is an epigenetic alteration crucial for regulating stress responses. Identifying large-scale DNA methylation at single nucleotide resolution is made possible by whole genome bisulfite sequencing. An essential task following the generation of bisulfite sequencing data is to detect differentially methylated cytosines (DMCs among treatments. Most statistical methods for DMC detection do not consider the dependency of methylation patterns across the genome, thus possibly inflating type I error. Furthermore, small sample sizes and weak methylation effects among different phenotype categories make it difficult for these statistical methods to accurately detect DMCs. To address these issues, the wavelet-based functional mixed model (WFMM was introduced to detect DMCs. To further examine the performance of WFMM in detecting weak differential methylation events, we used both simulated and empirical data and compare WFMM performance to a popular DMC detection tool methylKit. Analyses of simulated data that replicated the effects of the herbicide glyphosate on DNA methylation in Arabidopsis thaliana show that WFMM results in higher sensitivity and specificity in detecting DMCs compared to methylKit, especially when the methylation differences among phenotype groups are small. Moreover, the performance of WFMM is robust with respect to small sample sizes, making it particularly attractive considering the current high costs of bisulfite sequencing. Analysis of empirical Arabidopsis thaliana data under varying glyphosate dosages, and the analysis of monozygotic (MZ twins who have different pain sensitivities—both datasets have weak methylation effects of <1%—show that WFMM can identify more relevant DMCs related to the phenotype of interest than methylKit. Differentially methylated regions (DMRs are genomic regions with different DNA methylation status across biological samples. DMRs and DMCs are essentially the same
What Determines Firms’ Decisions to Formalize?
Neil McCulloch; Günther G. Schulze; Janina Voss
2010-01-01
In this paper we analyze the decision of small and micro firms to formalize, i.e. to obtain business and other licenses in rural Indonesia. We use the rural investment climate survey (RICS) that consists of non-farm rural enterprises, most of them microenterprises, and analyze the effect of formalization on tax payments, corruption, access to credit and revenue, taking into account the endogeneity of the formalization decision to such benefits and costs. We show, contrary to most of the liter...
NON-FORMAL EDUCATION, OVEREDUCATION AND WAGES
SANDRA NIETO; RAÚL RAMOS
2013-01-01
Why do overeducated workers participate in non-formal education activities? Do not they suffer from an excess of education? Using microdata from the Spanish sample of the 2007 Adult Education Survey, we have found that overeducated workers participate more than the rest in non-formal education and that they earn higher wages than overeducated workers who did not participate. This result can be interpreted as evidence that non-formal education allows overeducated workers to acquire new abiliti...
Survey of Existing Tools for Formal Verification.
Energy Technology Data Exchange (ETDEWEB)
Punnoose, Ratish J.; Armstrong, Robert C.; Wong, Matthew H.; Jackson, Mayo
2014-12-01
Formal methods have come into wide use because of their effectiveness in verifying "safety and security" requirements of digital systems; a set of requirements for which testing is mostly ineffective. Formal methods are routinely used in the design and verification of high-consequence digital systems in industry. This report outlines our work in assessing the capabilities of commercial and open source formal tools and the ways in which they can be leveraged in digital design workflows.
Fundamentals of the Pure Spinor Formalism
Hoogeveen, Joost
2010-01-01
This thesis presents recent developments within the pure spinor formalism, which has simplified amplitude computations in perturbative string theory, especially when spacetime fermions are involved. Firstly the worldsheet action of both the minimal and the non-minimal pure spinor formalism is derived from first principles, i.e. from an action with two dimensional diffeomorphism and Weyl invariance. Secondly the decoupling of unphysical states in the minimal pure spinor formalism is proved
Directory of Open Access Journals (Sweden)
Małgorzata Pokrywka
2014-11-01
Full Text Available The number of overweight and obese people is increasing at an alarming rate, especially in the developed and developing countries. Obesity is a major risk factor for diabetes, cardiovascular disease, and cancer, and in consequence for premature death. The development of obesity results from the interplay of both genetic and environmental factors, which include sedentary life style and abnormal eating habits. In the past few years a number of events accompanying obesity, affecting expression of genes which are not directly connected with the DNA base sequence (e.g. epigenetic changes, have been described. Epigenetic processes include DNA methylation, histone modifications such as acetylation, methylation, phosphorylation, ubiquitination, and sumoylation, as well as non-coding micro-RNA (miRNA synthesis. In this review, the known changes in the profile of DNA methylation as a factor affecting obesity and its complications are described.
A Mathematical Formalization Proposal for Business Growth
Directory of Open Access Journals (Sweden)
Gheorghe BAILESTEANU
2013-01-01
Full Text Available Economic sciences have known a spectacular evolution in the last century; beginning to use axiomatic methods, applying mathematical instruments as a decision-making tool. The quest to formalization needs to be addressed from various different angles, reducing entry and operating formal costs, increasing the incentives for firms to operate formally, reducing obstacles to their growth, and searching for inexpensive approaches through which to enforce compliancy with government regulations. This paper proposes a formalized approach to business growth, based on mathematics and logics, taking into consideration the particularities of the economic sector.
Formal Methods for Life-Critical Software
Butler, Ricky W.; Johnson, Sally C.
1993-01-01
The use of computer software in life-critical applications, such as for civil air transports, demands the use of rigorous formal mathematical verification procedures. This paper demonstrates how to apply formal methods to the development and verification of software by leading the reader step-by-step through requirements analysis, design, implementation, and verification of an electronic phone book application. The current maturity and limitations of formal methods tools and techniques are then discussed, and a number of examples of the successful use of formal methods by industry are cited.
Formal language constrained path problems
Energy Technology Data Exchange (ETDEWEB)
Barrett, C.; Jacob, R.; Marathe, M.
1997-07-08
In many path finding problems arising in practice, certain patterns of edge/vertex labels in the labeled graph being traversed are allowed/preferred, while others are disallowed. Motivated by such applications as intermodal transportation planning, the authors investigate the complexity of finding feasible paths in a labeled network, where the mode choice for each traveler is specified by a formal language. The main contributions of this paper include the following: (1) the authors show that the problem of finding a shortest path between a source and destination for a traveler whose mode choice is specified as a context free language is solvable efficiently in polynomial time, when the mode choice is specified as a regular language they provide algorithms with improved space and time bounds; (2) in contrast, they show that the problem of finding simple paths between a source and a given destination is NP-hard, even when restricted to very simple regular expressions and/or very simple graphs; (3) for the class of treewidth bounded graphs, they show that (i) the problem of finding a regular language constrained simple path between source and a destination is solvable in polynomial time and (ii) the extension to finding context free language constrained simple paths is NP-complete. Several extensions of these results are presented in the context of finding shortest paths with additional constraints. These results significantly extend the results in [MW95]. As a corollary of the results, they obtain a polynomial time algorithm for the BEST k-SIMILAR PATH problem studied in [SJB97]. The previous best algorithm was given by [SJB97] and takes exponential time in the worst case.
DEFF Research Database (Denmark)
Schönbeck, Jens Christian Sidney; Westh, Peter; Madsen, Jens Christian
2011-01-01
The complexation of 6 bile salts with various methylated β-cyclodextrins was studied to elucidate how the degree and pattern of substitution affects the binding. The structures of the CDs were determined by mass spectrometry and NMR techniques, and the structures of the inclusion complexes were...
Formal Engineering Hybrid Systems: Semantic Underpinnings
Bujorianu, M.C.; Bujorianu, L.M.
2008-01-01
In this work we investigate some issues in applying formal methods to hybrid system development and develop a categorical framework. We study the themes of stochastic reasoning, heterogeneous formal specification and retrenchment. Hybrid systems raise a rich pallets of aspects that need to be
Methodological imperfection and formalizations in scientific activity
International Nuclear Information System (INIS)
Svetlichny, G.
1987-01-01
Any mathematical formalization of scientific activity allows for imperfections in the methodology that is formalized. These can be of three types, dirty, rotten, and dammed. Restricting mathematical attention to those methods that cannot be construed to be imperfect drastically reduces the class of objects that must be analyzed, and related all other objects to these more regular ones. Examples are drawn from empirical logic
DNA expressions - A formal notation for DNA
Vliet, Rudy van
2015-01-01
We describe a formal notation for DNA molecules that may contain nicks and gaps. The resulting DNA expressions denote formal DNA molecules. Different DNA expressions may denote the same molecule. Such DNA expressions are called equivalent. We examine which DNA expressions are minimal, which
Formalizing Evaluation in Music Information Retrieval
DEFF Research Database (Denmark)
Sturm, Bob L.
2013-01-01
We develop a formalism to disambiguate the evaluation of music information retrieval systems. We define a ``system,'' what it means to ``analyze'' one, and make clear the aims, parts, design, execution, interpretation, and assumptions of its ``evaluation.'' We apply this formalism to discuss...
37 CFR 251.41 - Formal hearings.
2010-07-01
... ARBITRATION ROYALTY PANEL RULES AND PROCEDURES COPYRIGHT ARBITRATION ROYALTY PANEL RULES OF PROCEDURE Procedures of Copyright Arbitration Royalty Panels § 251.41 Formal hearings. (a) The formal hearings that will be conducted under the rules of this subpart are rate adjustment hearings and royalty fee...
Restorative Practices as Formal and Informal Education
Carter, Candice C.
2013-01-01
This article reviews restorative practices (RP) as education in formal and informal contexts of learning that are fertile sites for cultivating peace. Formal practices involve instruction about response to conflict, while informal learning occurs beyond academic lessons. The research incorporated content analysis and a critical examination of the…
Multiverse in the Third Quantized Formalism
International Nuclear Information System (INIS)
Faizal Mir
2014-01-01
In this paper we will analyze the third quantization of gravity in path integral formalism. We will use the time-dependent version of Wheeler—DeWitt equation to analyze the multiverse in this formalism. We will propose a mechanism for baryogenesis to occur in the multiverse, without violating the baryon number conservation. (general)
Formal balancing of chemical reaction networks
van der Schaft, Abraham; Rao, S.; Jayawardhana, B.
2016-01-01
In this paper we recall and extend the main results of Van der Schaft, Rao, Jayawardhana (2015) concerning the use of Kirchhoff’s Matrix Tree theorem in the explicit characterization of complex-balanced reaction networks and the notion of formal balancing. The notion of formal balancing corresponds
The simplest formal argument for fitness optimization
Indian Academy of Sciences (India)
The Formal Darwinism Project aims to provide a formal argument linking population genetics to fitness optimization, which of necessity includes defining fitness. This bridges the gulf between those biologists who assume that natural selection leads to something close to fitness optimization and those biologists who believe ...
Opinion dynamics model based on quantum formalism
Energy Technology Data Exchange (ETDEWEB)
Artawan, I. Nengah, E-mail: nengahartawan@gmail.com [Theoretical Physics Division, Department of Physics, Udayana University (Indonesia); Trisnawati, N. L. P., E-mail: nlptrisnawati@gmail.com [Biophysics, Department of Physics, Udayana University (Indonesia)
2016-03-11
Opinion dynamics model based on quantum formalism is proposed. The core of the quantum formalism is on the half spin dynamics system. In this research the implicit time evolution operators are derived. The analogy between the model with Deffuant dan Sznajd models is discussed.
A computational formalization for partial evaluation
DEFF Research Database (Denmark)
Hatcliff, John; Danvy, Olivier
1997-01-01
We formalize a partial evaluator for Eugenio Moggi's computational metalanguage. This formalization gives an evaluation-order independent view of binding-time analysis and program specialization, including a proper treatment of call unfolding. It also enables us to express the essence of `control...
Rapid Prototyping of Formally Modelled Distributed Systems
Buchs, Didier; Buffo, Mathieu; Titsworth, Frances M.
1999-01-01
This paper presents various kinds of prototypes, used in the prototyping of formally modelled distributed systems. It presents the notions of prototyping techniques and prototype evolution, and shows how to relate them to the software life-cycle. It is illustrated through the use of the formal modelling language for distributed systems CO-OPN/2.
Formal analysis of a fair payment protocol
J.G. Cederquist; M.T. Dashti (Mohammad)
2004-01-01
textabstractWe formally specify a payment protocol. This protocol is intended for fair exchange of time-sensitive data. Here the ?-CRL language is used to formalize the protocol. Fair exchange properties are expressed in the regular alternation-free ?-calculus. These properties are then verified
Formal Analysis of a Fair Payment Protocol
Cederquist, J.G.; Dashti, M.T.
2004-01-01
We formally specify a payment protocol. This protocol is intended for fair exchange of timesensitive data. Here the μCRL language is used to formalize the protocol. Fair exchange properties are expressed in the regular alternation-free μ-calculus. These properties are then verified using the finite
Formal Analysis of a Fair Payment Protocol
Cederquist, J.G.; Dashti, Muhammad Torabi; Dimitrakos, Theo; Martinelli, Fabio
We formally specify a payment protocol described by Vogt et al. This protocol is intended for fair exchange of time-sensitive data. Here the mCRL language is used to formalize the protocol. Fair exchange properties are expressed in the regular alternation-free mu-calculus. These properties are then
On Fitting a Formal Method into Practice
DEFF Research Database (Denmark)
Gmehlich, Rainer; Grau, Katrin; Hallerstede, Stefan
2011-01-01
. The interaction between the two proved to be crucial for the success of the case study. The heart of the problem was tracing informal requirements from Problem Frames descriptions to formal Event-B models. To a large degree, this issue dictated the approach that had to be used for formal modelling. A dedicated...
A Conceptual Formalization of Crosscutting in AOSD
van den Berg, Klaas; Conejero, J.M.
2005-01-01
We propose a formalization of crosscutting based on a conceptual framework for AOSD. Crosscutting is clearly distinguished from the related concepts scattering and tangling. The definitions of these concepts are formalized and visualized with matrices and matrix operations. This allows more precise
Industrial Practice in Formal Methods : A Review
DEFF Research Database (Denmark)
Bicarregui, Juan C.; Fitzgerald, John; Larsen, Peter Gorm
2009-01-01
We examine the the industrial application of formal methods using data gathered in a review of 62 projects taking place over the last 25 years. The review suggests that formal methods are being applied in a wide range of application domains, with increasingly strong tool support. Significant chal...... challenges remain in providing usable tools that can be integrated into established development processes; in education and training; in taking formal methods from first use to second use, and in gathering and evidence to support informed selection of methods and tools.......We examine the the industrial application of formal methods using data gathered in a review of 62 projects taking place over the last 25 years. The review suggests that formal methods are being applied in a wide range of application domains, with increasingly strong tool support. Significant...
SBME : Exploring boundaries between formal, non-formal, and informal learning
Shahoumian, Armineh; Parchoma, Gale; Saunders, Murray; Hanson, Jacky; Dickinson, Mike; Pimblett, Mark
2013-01-01
In medical education learning extends beyond university settings into practice. Non-formal and informal learning support learners’ efforts to meet externally set and learner-identified objectives. In SBME research, boundaries between formal, non-formal, and informal learning have not been widely explored. Whether SBME fits within or challenges these categories can make a contribution. Formal learning is described in relation to educational settings, planning, assessment, and accreditation. In...
Protein methylation in pea chloroplasts
International Nuclear Information System (INIS)
Niemi, K.J.; Adler, J.; Selman, B.R.
1990-01-01
The methylation of chloroplast proteins has been investigated by incubating intact pea (Pisum sativum) chloroplasts with [ 3 H-methyl]-S-adenosylmethionine. Incubation in the light increases the amount of methylation in both the thylakoid and stromal fractions. Numerous thylakoid proteins serve as substrates for the methyltransfer reactions. Three of these thylakoid proteins are methylated to a significantly greater extent in the light than in the dark. The primary stromal polypeptide methylated is the large subunit of ribulose bisphosphate carboxylase/oxygenase. One other stromal polypeptide is also methylated much more in the light than in the dark. Two distinct types of protein methylation occur. One methylinkage is stable to basic conditions whereas a second type is base labile. The base-stable linkage is indicative of N-methylation of amino acid residues while base-lability is suggestive of carboxymethylation of amino acid residues. Labeling in the light increases the percentage of methylation that is base labile in the thylakoid fraction while no difference is observed in the amount of base-labile methylations in light-labeled and dark-labeled stromal proteins. Also suggestive of carboxymethylation is the detection of volatile [ 3 H]methyl radioactivity which increases during the labeling period and is greater in chloroplasts labeled in the light as opposed to being labeled in the dark; this implies in vivo turnover of the [ 3 H]methyl group
Methylation of food commodities during fumigation with methyl bromide
International Nuclear Information System (INIS)
Starratt, A.N.; Bond, E.J.
1990-01-01
Sites of methylation in several commodities (wheat, oatmeal, peanuts, almonds, apples, oranges, maize, alfalfa and potatoes) during fumigation with 14 C-methyl bromide were studied. Differences were observed in levels of the major volatiles: methanol, dimethyl sulphide and methyl mercaptan, products of O- and S-methylation, resulting from treatment of the fumigated materials with 1N sodium hydroxide. In studies of maize and wheat, histidine was the amino acid which underwent the highest level of N-methylation. (author). 24 refs, 3 tabs
Improving Learner Outcomes in Lifelong Education: Formal Pedagogies in Non-Formal Learning Contexts?
Zepke, Nick; Leach, Linda
2006-01-01
This article explores how far research findings about successful pedagogies in formal post-school education might be used in non-formal learning contexts--settings where learning may not lead to formal qualifications. It does this by examining a learner outcomes model adapted from a synthesis of research into retention. The article first…
Formal Analysis Of Use Case Diagrams
Directory of Open Access Journals (Sweden)
Radosław Klimek
2010-01-01
Full Text Available Use case diagrams play an important role in modeling with UML. Careful modeling is crucialin obtaining a correct and efficient system architecture. The paper refers to the formalanalysis of the use case diagrams. A formal model of use cases is proposed and its constructionfor typical relationships between use cases is described. Two methods of formal analysis andverification are presented. The first one based on a states’ exploration represents a modelchecking approach. The second one refers to the symbolic reasoning using formal methodsof temporal logic. Simple but representative example of the use case scenario verification isdiscussed.
Towards Formal Implementation of PUS Standard
Ilić, D.
2009-05-01
As an effort to promote the reuse of on-board and ground systems ESA developed a standard for packet telemetry and telecommand - PUS. It defines a set of standard service models with the corresponding structures of the associated telemetry and telecommand packets. Various missions then can choose to implement those standard PUS services that best conform to their specific requirements. In this paper we propose a formal development (based on the Event-B method) of reusable service patterns, which can be instantiated for concrete application. Our formal models allow us to formally express and verify specific service properties including various telecommand and telemetry packet structure validation.
SELF-EFFICACY OF FORMALLY AND NON-FORMALLY TRAINED PUBLIC SECTOR TEACHERS
Directory of Open Access Journals (Sweden)
Muhammad Nadeem ANWAR
2009-07-01
Full Text Available The main objective of the study was to compare the formally and non-formally trained in-service public sector teachers’ Self-efficacy. Five hypotheses were developed describing no difference in the self-efficacy of formally and non-formally trained teachers to influence decision making, influence school resources, instructional self-efficacy, disciplinary self-efficacy and create positive school climate. Teacher Efficacy Instrument (TSES developed by Bandura (2001 consisting of thirty 9-point items was used in the study. 342 formally trained and 255 non-formally trained respondents’ questionnaires were received out of 1500 mailed. The analysis of data revealed that the formally trained public sector teachers are high in their self-efficacy on all the five categories: to influence decision making, to influence school resources, instructional self-efficacy, disciplinary self-efficacy and self-efficacy to create positive school climate.
Prediction of methyl-side Chain Dynamics in Proteins
International Nuclear Information System (INIS)
Ming Dengming; Brueschweiler, Rafael
2004-01-01
A simple analytical model is presented for the prediction of methyl-side chain dynamics in comparison with S 2 order parameters obtained by NMR relaxation spectroscopy. The model, which is an extension of the local contact model for backbone order parameter prediction, uses a static 3D protein structure as input. It expresses the methyl-group S 2 order parameters as a function of local contacts of the methyl carbon with respect to the neighboring atoms in combination with the number of consecutive mobile dihedral angles between the methyl group and the protein backbone. For six out of seven proteins the prediction results are good when compared with experimentally determined methyl-group S 2 values with an average correlation coefficient r-bar=0.65±0.14. For the unusually rigid cytochrome c 2 no significant correlation between prediction and experiment is found. The presented model provides independent support for the reliability of current side-chain relaxation methods along with their interpretation by the model-free formalism
Toward a formal ontology for narrative
Directory of Open Access Journals (Sweden)
Ciotti, Fabio
2016-03-01
Full Text Available In this paper the rationale and the first draft of a formal ontology for modeling narrative texts are presented. Building on the semiotic and structuralist narratology, and on the work carried out in the late 1980s by Giuseppe Gigliozzi in Italy, the focus of my research are the concepts of character and of narrative world/space. This formal model is expressed in the OWL 2 ontology language. The main reason to adopt a formal modeling approach is that I consider the purely probabilistic-quantitative methods (now widespread in digital literary studies inadequate. An ontology, on one hand provides a tool for the analysis of strictly literary texts. On the other hand (though beyond the scope of the present work, its formalization can also represent a significant contribution towards grounding the application of storytelling methods outside of scholarly contexts.
A hydrodynamic formalism for Brownian systems
International Nuclear Information System (INIS)
Pina, E.; Rosales, M.A.
1981-01-01
A formal hydrodynamic approach to Brownian motion is presented and the corresponding equations are derived. Hydrodynamic quantities are expressed in terms of the physical variables characterizing the Brownian systems. Contact is made with the hydrodynamic model of Quantum Mechanics. (author)
Infinitesimal Deformations of a Formal Symplectic Groupoid
Karabegov, Alexander
2011-09-01
Given a formal symplectic groupoid G over a Poisson manifold ( M, π 0), we define a new object, an infinitesimal deformation of G, which can be thought of as a formal symplectic groupoid over the manifold M equipped with an infinitesimal deformation {π_0 + \\varepsilon π_1} of the Poisson bivector field π 0. To any pair of natural star products {(ast,tildeast)} having the same formal symplectic groupoid G we relate an infinitesimal deformation of G. We call it the deformation groupoid of the pair {(ast,tildeast)} . To each star product with separation of variables {ast} on a Kähler-Poisson manifold M we relate another star product with separation of variables {hatast} on M. We build an algorithm for calculating the principal symbols of the components of the logarithm of the formal Berezin transform of a star product with separation of variables {ast} . This algorithm is based upon the deformation groupoid of the pair {(ast,hatast)}.
Does Formal Environmental Knowledge Inform the Everyday ...
African Journals Online (AJOL)
How do senior secondary biology learners from three schools in Lesotho use this ... environmental literacy as a goal of science education is mentioned. ..... formal schooling context) or actions informed by informal information, which we ...
Towards a Formal Treatment of Implicit Invocation
National Research Council Canada - National Science Library
Dingel, J
1997-01-01
.... A formal computational model for implicit invocation is presented. We develop a verification framework for implicit invocation that is based on Jones' rely/guarantee reasoning for concurrent systems Jon83,St(phi)91...
Formal education of curriculum and instructional designers
McKenney, Susan; Visscher-Voerman, Irene
2013-01-01
McKenney, S., & Visscher-Voerman, I. (2013). Formal education of curriculum and instructional designers. Educational Designer, 2(6). Available online: http://www.educationaldesigner.org/ed/volume2/issue6/article20/index.htm
Transitions from Formal Education to the Workplace
Olson, Joann S.
2014-01-01
This chapter frames the transition to adulthood in the context of the moving from formal educational settings to the often less-structured learning that occurs in workplace settings. Although schooling may end, learning continues.
Statistical Survey of Non-Formal Education
Directory of Open Access Journals (Sweden)
Ondřej Nývlt
2012-12-01
Full Text Available focused on a programme within a regular education system. Labour market flexibility and new requirements on employees create a new domain of education called non-formal education. Is there a reliable statistical source with a good methodological definition for the Czech Republic? Labour Force Survey (LFS has been the basic statistical source for time comparison of non-formal education for the last ten years. Furthermore, a special Adult Education Survey (AES in 2011 was focused on individual components of non-formal education in a detailed way. In general, the goal of the EU is to use data from both internationally comparable surveys for analyses of the particular fields of lifelong learning in the way, that annual LFS data could be enlarged by detailed information from AES in five years periods. This article describes reliability of statistical data aboutnon-formal education. This analysis is usually connected with sampling and non-sampling errors.
Towards a Formal Model of Social Data
DEFF Research Database (Denmark)
Mukkamala, Raghava Rao; Vatrapu, Ravi; Hussain, Abid
, transform, analyse, and report social data from social media platforms such as Facebook and twitter. Formal methods, models and tools for social data are largely limited to graph theoretical approaches informing conceptual developments in relational sociology and methodological developments in social...... network analysis. As far as we know, there are no integrated modeling approaches to social data across the conceptual, formal and software realms. Social media analytics can be undertaken in two main ways - ”Social Graph Analytics” and ”Social Text Analytics” (Vatrapu, in press/2013). Social graph......, we exemplify the semantics of the formal model with real-world social data examples. Third, we briefly present and discuss the Social Data Analytics Tool (SODATO) that realizes the conceptual model in software and provisions social data for computational social science analysis based on the formal...
Formalisms for reuse and systems integration
Rubin, Stuart
2015-01-01
Reuse and integration are defined as synergistic concepts, where reuse addresses how to minimize redundancy in the creation of components; while, integration focuses on component composition. Integration supports reuse and vice versa. These related concepts support the design of software and systems for maximizing performance while minimizing cost. Knowledge, like data, is subject to reuse; and, each can be interpreted as the other. This means that inherent complexity, a measure of the potential utility of a system, is directly proportional to the extent to which it maximizes reuse and integration. Formal methods can provide an appropriate context for the rigorous handling of these synergistic concepts. Furthermore, formal languages allow for non ambiguous model specification; and, formal verification techniques provide support for insuring the validity of reuse and integration mechanisms. This edited book includes 12 high quality research papers written by experts in formal aspects of reuse and integratio...
El Salvador - Non-Formal Skills Development
Millennium Challenge Corporation — The Non-Formal Skills Development Sub-Activity had a budget of $5 million (USD) to provide short-term training to vulnerable populations in El Salvador's Northern...
Film for Non-Formal Education.
Jenkins, Janet
1979-01-01
Looks at educational factors in using television or cinema film for non-formal education in developing nations. Styles of presentation in films are discussed, and suggestions are made for assessing effectiveness. (JEG)
Formal solutions of inverse scattering problems. III
International Nuclear Information System (INIS)
Prosser, R.T.
1980-01-01
The formal solutions of certain three-dimensional inverse scattering problems presented in papers I and II of this series [J. Math. Phys. 10, 1819 (1969); 17 1175 (1976)] are obtained here as fixed points of a certain nonlinear mapping acting on a suitable Banach space of integral kernels. When the scattering data are sufficiently restricted, this mapping is shown to be a contraction, thereby establishing the existence, uniqueness, and continuous dependence on the data of these formal solutions
Formalization of Many-Valued Logics
DEFF Research Database (Denmark)
Villadsen, Jørgen; Schlichtkrull, Anders
2017-01-01
Partiality is a key challenge for computational approaches to artificial intelligence in general and natural language in particular. Various extensions of classical two-valued logic to many-valued logics have been investigated in order to meet this challenge. We use the proof assistant Isabelle...... to formalize the syntax and semantics of many-valued logics with determinate as well as indeterminate truth values. The formalization allows for a concise presentation and makes automated verification possible....
Young People, Entrepreneurship And Non Formal Learning
Pantea, Maria-Carmen; Diroescu, Raluca; Podlasek-Ziegler, Maria
2016-01-01
The book was published by SALTO-Youth Participation, a Resource Centre of the European Commission. It looks into the relationship between youth work (non-formal learning) and entrepreneurship. The book explores the theoretical developments in the field, the ethical dilemmas and tensions, and proposes practice-oriented information: illustrative examples, strategies for action and methods of non-formal education. Structured in 24 chapters, the book is an opportunity to open up debates and quest...
Improved formalism for precision Higgs coupling fits
Barklow, Tim; Fujii, Keisuke; Jung, Sunghoon; Karl, Robert; List, Jenny; Ogawa, Tomohisa; Peskin, Michael E.; Tian, Junping
2018-03-01
Future e+e- colliders give the promise of model-independent determinations of the couplings of the Higgs boson. In this paper, we present an improved formalism for extracting Higgs boson couplings from e+e- data, based on the effective field theory description of corrections to the Standard Model. We apply this formalism to give projections of Higgs coupling accuracies for stages of the International Linear Collider and for other proposed e+e- colliders.
Improved formalism for precision Higgs coupling fits
International Nuclear Information System (INIS)
Barklow, Tim; Peskin, Michael E.; Jung, Sunghoon; Tian, Junping
2017-08-01
Future e + e - colliders give the promise of model-independent determinations of the couplings of the Higgs boson. In this paper, we present an improved formalism for extracting Higgs boson couplings from e + e - data, based on the Effective Field Theory description of corrections to the Standard Model. We apply this formalism to give projections of Higgs coupling accuracies for stages of the International Linear Collider and for other proposed e + e - colliders.
A computational formalization for partial evaluation
DEFF Research Database (Denmark)
Hatcliff, John; Danvy, Olivier
1996-01-01
We formalize a partial evaluator for Eugenio Moggi's computational metalanguage. This formalization gives an evaluation-order independent view of binding-time analysis and program specialization, including a proper treatment of call unfolding. It also enables us to express the essence of `control......-based binding-time improvements' for let expressions. Specically, we prove that the binding-time improvements given by `continuation-based specialization' can be expressed in the metalanguage via monadic laws....
Methylation in hepatocellular carcinoma
Directory of Open Access Journals (Sweden)
Regina M. Santella
2007-02-01
Full Text Available
The development of HCC is a complex, multistep, multistage process. The molecular pathogenesis of HCC appears to involve multiple genetic aberrations in the molecular control of hepatocyte proliferation, differentiation and death and the maintenance of genomic integrity. This process is influenced by the cumulative activation and inactivation of oncogenes, tumor suppressor genes and other genes. p53, a tumor suppressor gene, is the most frequently mutated gene in human cancers. There is also a striking sequence specific binding and induction of mutations by AFB1 at codon 249 of p53 in HCC.
Epigenetic alterations are also involved in cancer development and progression. Methylation of promoter CpG islands is associated with inhibition of transcriptional initiation and permanent silencing of downstream genes.
It is now known that most important tumor suppressor genes are inactivated, not only by mutations and deletions but also by promoter methylation. Several studies indicated that p16, p15, RASSF1A, MGMT, and GSTP1 promoter hypermethylation are prevalent in HCC. In addition, geographic variation in the methylation status of tumor DNA indicates that environmental factors may influence the frequent and concordant degree of hypermethylation in multiple genes in HCC and that epigeneticenvironmental interactions may be involved in hepatocarcinogenesis. We have found significant relationships between promoter methylation and AFB1-DNA adducts confirming the impact of environmental exposures on gene methylation.
DNA isolated from serum or plasma of cancer patients frequently contains the same genetic and
Application of Formal Methods in Software Engineering
Directory of Open Access Journals (Sweden)
Adriana Morales
2011-12-01
Full Text Available The purpose of this research work is to examine: (1 why are necessary the formal methods for software systems today, (2 high integrity systems through the methodology C-by-C –Correctness-by-Construction–, and (3 an affordable methodology to apply formal methods in software engineering. The research process included reviews of the literature through Internet, in publications and presentations in events. Among the Research results found that: (1 there is increasing the dependence that the nations have, the companies and people of software systems, (2 there is growing demand for software Engineering to increase social trust in the software systems, (3 exist methodologies, as C-by-C, that can provide that level of trust, (4 Formal Methods constitute a principle of computer science that can be applied software engineering to perform reliable process in software development, (5 software users have the responsibility to demand reliable software products, and (6 software engineers have the responsibility to develop reliable software products. Furthermore, it is concluded that: (1 it takes more research to identify and analyze other methodologies and tools that provide process to apply the Formal Software Engineering methods, (2 Formal Methods provide an unprecedented ability to increase the trust in the exactitude of the software products and (3 by development of new methodologies and tools is being achieved costs are not more a disadvantage for application of formal methods.
Formality of the Chinese collective leadership.
Li, Haiying; Graesser, Arthur C
2016-09-01
We investigated the linguistic patterns in the discourse of four generations of the collective leadership of the Communist Party of China (CPC) from 1921 to 2012. The texts of Mao Zedong, Deng Xiaoping, Jiang Zemin, and Hu Jintao were analyzed using computational linguistic techniques (a Chinese formality score) to explore the persuasive linguistic features of the leaders in the contexts of power phase, the nation's education level, power duration, and age. The study was guided by the elaboration likelihood model of persuasion, which includes a central route (represented by formal discourse) versus a peripheral route (represented by informal discourse) to persuasion. The results revealed that these leaders adopted the formal, central route more when they were in power than before they came into power. The nation's education level was a significant factor in the leaders' adoption of the persuasion strategy. The leaders' formality also decreased with their increasing age and in-power times. However, the predictability of these factors for formality had subtle differences among the different types of leaders. These results enhance our understanding of the Chinese collective leadership and the role of formality in politically persuasive messages.
Formal Ontologies and Uncertainty. In Geographical Knowledge
Directory of Open Access Journals (Sweden)
Matteo Caglioni
2014-05-01
Full Text Available Formal ontologies have proved to be a very useful tool to manage interoperability among data, systems and knowledge. In this paper we will show how formal ontologies can evolve from a crisp, deterministic framework (ontologies of hard knowledge to new probabilistic, fuzzy or possibilistic frameworks (ontologies of soft knowledge. This can considerably enlarge the application potential of formal ontologies in geographic analysis and planning, where soft knowledge is intrinsically linked to the complexity of the phenomena under study. The paper briefly presents these new uncertainty-based formal ontologies. It then highlights how ontologies are formal tools to define both concepts and relations among concepts. An example from the domain of urban geography finally shows how the cause-to-effect relation between household preferences and urban sprawl can be encoded within a crisp, a probabilistic and a possibilistic ontology, respectively. The ontology formalism will also determine the kind of reasoning that can be developed from available knowledge. Uncertain ontologies can be seen as the preliminary phase of more complex uncertainty-based models. The advantages of moving to uncertainty-based models is evident: whether it is in the analysis of geographic space or in decision support for planning, reasoning on geographic space is almost always reasoning with uncertain knowledge of geographic phenomena.
DNA methylation and memory formation.
Day, Jeremy J; Sweatt, J David
2010-11-01
Memory formation and storage require long-lasting changes in memory-related neuronal circuits. Recent evidence indicates that DNA methylation may serve as a contributing mechanism in memory formation and storage. These emerging findings suggest a role for an epigenetic mechanism in learning and long-term memory maintenance and raise apparent conundrums and questions. For example, it is unclear how DNA methylation might be reversed during the formation of a memory, how changes in DNA methylation alter neuronal function to promote memory formation, and how DNA methylation patterns differ between neuronal structures to enable both consolidation and storage of memories. Here we evaluate the existing evidence supporting a role for DNA methylation in memory, discuss how DNA methylation may affect genetic and neuronal function to contribute to behavior, propose several future directions for the emerging subfield of neuroepigenetics, and begin to address some of the broader implications of this work.
Fourier Series Formalization in ACL2(r
Directory of Open Access Journals (Sweden)
Cuong K. Chau
2015-09-01
Full Text Available We formalize some basic properties of Fourier series in the logic of ACL2(r, which is a variant of ACL2 that supports reasoning about the real and complex numbers by way of non-standard analysis. More specifically, we extend a framework for formally evaluating definite integrals of real-valued, continuous functions using the Second Fundamental Theorem of Calculus. Our extended framework is also applied to functions containing free arguments. Using this framework, we are able to prove the orthogonality relationships between trigonometric functions, which are the essential properties in Fourier series analysis. The sum rule for definite integrals of indexed sums is also formalized by applying the extended framework along with the First Fundamental Theorem of Calculus and the sum rule for differentiation. The Fourier coefficient formulas of periodic functions are then formalized from the orthogonality relations and the sum rule for integration. Consequently, the uniqueness of Fourier sums is a straightforward corollary. We also present our formalization of the sum rule for definite integrals of infinite series in ACL2(r. Part of this task is to prove the Dini Uniform Convergence Theorem and the continuity of a limit function under certain conditions. A key technique in our proofs of these theorems is to apply the overspill principle from non-standard analysis.
Whole-genome methylation caller designed for methyl- DNA ...
African Journals Online (AJOL)
etchie
2013-02-20
Feb 20, 2013 ... Key words: Methyl-DNA immunoprecipitation, next-generation sequencing, Hidden ... its response to environmental cues. .... have a great potential to become the most cost-effective ... hg18 reference genome (set to 0 if not present in retrieved reads). ..... DNA methylation patterns and epigenetic memory.
Formal Modeling and Analysis of Timed Systems
DEFF Research Database (Denmark)
Larsen, Kim Guldstrand; Niebert, Peter
This book constitutes the thoroughly refereed post-proceedings of the First International Workshop on Formal Modeling and Analysis of Timed Systems, FORMATS 2003, held in Marseille, France in September 2003. The 19 revised full papers presented together with an invited paper and the abstracts of ...... systems, discrete time systems, timed languages, and real-time operating systems....... of two invited talks were carefully selected from 36 submissions during two rounds of reviewing and improvement. All current aspects of formal method for modeling and analyzing timed systems are addressed; among the timed systems dealt with are timed automata, timed Petri nets, max-plus algebras, real-time......This book constitutes the thoroughly refereed post-proceedings of the First International Workshop on Formal Modeling and Analysis of Timed Systems, FORMATS 2003, held in Marseille, France in September 2003. The 19 revised full papers presented together with an invited paper and the abstracts...
Formal Analysis of Graphical Security Models
DEFF Research Database (Denmark)
Aslanyan, Zaruhi
, software components and human actors interacting with each other to form so-called socio-technical systems. The importance of socio-technical systems to modern societies requires verifying their security properties formally, while their inherent complexity makes manual analyses impracticable. Graphical...... models for security offer an unrivalled opportunity to describe socio-technical systems, for they allow to represent different aspects like human behaviour, computation and physical phenomena in an abstract yet uniform manner. Moreover, these models can be assigned a formal semantics, thereby allowing...... formal verification of their properties. Finally, their appealing graphical notations enable to communicate security concerns in an understandable way also to non-experts, often in charge of the decision making. This dissertation argues that automated techniques can be developed on graphical security...
Formal verification of industrial control systems
CERN. Geneva
2015-01-01
Verification of critical software is a high priority but a challenging task for industrial control systems. For many kinds of problems, testing is not an efficient method. Formal methods, such as model checking appears to be an appropriate complementary method. However, it is not common to use model checking in industry yet, as this method needs typically formal methods expertise and huge computing power. In the EN-ICE-PLC section, we are working on a [methodology][1] and a tool ([PLCverif][2]) to overcome these challenges and to integrate formal verification in the development process of our PLC-based control systems. [1]: http://cern.ch/project-plc-formalmethods [2]: http://cern.ch/plcverif
Formalizing Darwinism and inclusive fitness theory.
Grafen, Alan
2009-11-12
Inclusive fitness maximization is a basic building block for biological contributions to any theory of the evolution of society. There is a view in mathematical population genetics that nothing is caused to be maximized in the process of natural selection, but this is explained as arising from a misunderstanding about the meaning of fitness maximization. Current theoretical work on inclusive fitness is discussed, with emphasis on the author's 'formal Darwinism project'. Generally, favourable conclusions are drawn about the validity of assuming fitness maximization, but the need for continuing work is emphasized, along with the possibility that substantive exceptions may be uncovered. The formal Darwinism project aims more ambitiously to represent in a formal mathematical framework the central point of Darwin's Origin of Species, that the mechanical processes of inheritance and reproduction can give rise to the appearance of design, and it is a fitting ambition in Darwin's bicentenary year to capture his most profound discovery in the lingua franca of science.
First order formalism for quantum gravity
International Nuclear Information System (INIS)
Gleiser, M.; Holman, R.; Neto, N.P.
1987-05-01
We develop a first order formalism for the quantization of gravity. We take as canonical variables both the induced metric and the extrinsic curvature of the (d - 1) -dimensional hypersurfaces obtained by the foliation of the d - dimensional spacetime. After solving the constraint algebra we use the Dirac formalism to quantize the theory and obtain a new representation for the Wheeler-DeWitt equation, defined in the functional space of the extrinsic curvature. We also show how to obtain several different representations of the Wheeler-DeWitt equation by considering actions differing by a total divergence. In particular, the intrinsic and extrinsic time approaches appear in a natural way, as do equivalent representations obtained by functional Fourier transforms of appropriate variables. We conclude with some remarks about the construction of the Hilbert space within the first order formalism. 10 refs
Enhancing System Realisation in Formal Model Development
DEFF Research Database (Denmark)
Tran-Jørgensen, Peter Würtz Vinther
and requirements of software extensions targeting Overture. The tools developed in this PhD project have successfully supported three case studies from externally funded projects. The feedback received from the case study work has further helped improve the code generation infrastructure and the tools built using...... implementation. One way to realise the system’s software is by automatically generating it from the formal specification – a technique referred to as code generation. However, in general it is difficult to make guarantees about the correctness of the generated code – especially while requiring automation...... of the steps involved in realising the formal specification. This PhD dissertation investigates ways to improve the automation of the steps involved in realising and validating a system based on a formal specification. The approach aims to develop properly designed software tools which support the integration...
Towards Formal Verification of a Separation Microkernel
Butterfield, Andrew; Sanan, David; Hinchey, Mike
2013-08-01
The best approach to verifying an IMA separation kernel is to use a (fixed) time-space partitioning kernel with a multiple independent levels of separation (MILS) architecture. We describe an activity that explores the cost and feasibility of doing a formal verification of such a kernel to the Common Criteria (CC) levels mandated by the Separation Kernel Protection Profile (SKPP). We are developing a Reference Specification of such a kernel, and are using higher-order logic (HOL) to construct formal models of this specification and key separation properties. We then plan to do a dry run of part of a formal proof of those properties using the Isabelle/HOL theorem prover.
Rapidly converging path integral formalism. Pt. 1
International Nuclear Information System (INIS)
Bender, I.; Gromes, D.; Marquard, U.
1990-01-01
The action to be used in the path integral formalism is expanded in a systematic way in powers of the time spacing ε in order to optimize the convergence to the continuum limit. This modifies and extends the usual formalism in a transparent way. The path integral approximation to the Green function obtained by this method approaches the continuum Green function with a higher power of ε than the usual one. The general theoretical derivations are exemplified analytically for the harmonic oscillator and by Monte Carlo methods for the anharmonic oscillator. We also show how curvilinear coordinates and curved spaces can naturally be treated within this formalism. Work on field theory is in progress. (orig.)
Automated Formal Verification for PLC Control Systems
Fernández Adiego, Borja
2014-01-01
Programmable Logic Controllers (PLCs) are widely used devices used in industrial control systems. Ensuring that the PLC software is compliant with its specification is a challenging task. Formal verification has become a recommended practice to ensure the correctness of the safety-critical software. However, these techniques are still not widely applied in industry due to the complexity of building formal models, which represent the system and the formalization of requirement specifications. We propose a general methodology to perform automated model checking of complex properties expressed in temporal logics (e.g. CTL, LTL) on PLC programs. This methodology is based on an Intermediate Model (IM), meant to transform PLC programs written in any of the languages described in the IEC 61131-3 standard (ST, IL, etc.) to different modeling languages of verification tools. This approach has been applied to CERN PLC programs validating the methodology.
User Interface Technology for Formal Specification Development
Lowry, Michael; Philpot, Andrew; Pressburger, Thomas; Underwood, Ian; Lum, Henry, Jr. (Technical Monitor)
1994-01-01
Formal specification development and modification are an essential component of the knowledge-based software life cycle. User interface technology is needed to empower end-users to create their own formal specifications. This paper describes the advanced user interface for AMPHION1 a knowledge-based software engineering system that targets scientific subroutine libraries. AMPHION is a generic, domain-independent architecture that is specialized to an application domain through a declarative domain theory. Formal specification development and reuse is made accessible to end-users through an intuitive graphical interface that provides semantic guidance in creating diagrams denoting formal specifications in an application domain. The diagrams also serve to document the specifications. Automatic deductive program synthesis ensures that end-user specifications are correctly implemented. The tables that drive AMPHION's user interface are automatically compiled from a domain theory; portions of the interface can be customized by the end-user. The user interface facilitates formal specification development by hiding syntactic details, such as logical notation. It also turns some of the barriers for end-user specification development associated with strongly typed formal languages into active sources of guidance, without restricting advanced users. The interface is especially suited for specification modification. AMPHION has been applied to the domain of solar system kinematics through the development of a declarative domain theory. Testing over six months with planetary scientists indicates that AMPHION's interactive specification acquisition paradigm enables users to develop, modify, and reuse specifications at least an order of magnitude more rapidly than manual program development.
Infinitesimal deformations of a formal symplectic groupoid
Karabegov, Alexander
2010-01-01
Given a formal symplectic groupoid $G$ over a Poisson manifold $(M, \\pi_0)$, we define a new object, an infinitesimal deformation of $G$, which can be thought of as a formal symplectic groupoid over the manifold $M$ equipped with an infinitesimal deformation $\\pi_0 + \\epsilon \\pi_1$ of the Poisson bivector field $\\pi_0$. The source and target mappings of a deformation of $G$ are deformations of the source and target mappings of $G$. To any pair of natural star products $(\\ast, \\tilde\\ast)$ ha...
Keldysh formalism for multiple parallel worlds
International Nuclear Information System (INIS)
Ansari, M.; Nazarov, Y. V.
2016-01-01
We present a compact and self-contained review of the recently developed Keldysh formalism for multiple parallel worlds. The formalism has been applied to consistent quantum evaluation of the flows of informational quantities, in particular, to the evaluation of Renyi and Shannon entropy flows. We start with the formulation of the standard and extended Keldysh techniques in a single world in a form convenient for our presentation. We explain the use of Keldysh contours encompassing multiple parallel worlds. In the end, we briefly summarize the concrete results obtained with the method.
Keldysh formalism for multiple parallel worlds
Ansari, M.; Nazarov, Y. V.
2016-03-01
We present a compact and self-contained review of the recently developed Keldysh formalism for multiple parallel worlds. The formalism has been applied to consistent quantum evaluation of the flows of informational quantities, in particular, to the evaluation of Renyi and Shannon entropy flows. We start with the formulation of the standard and extended Keldysh techniques in a single world in a form convenient for our presentation. We explain the use of Keldysh contours encompassing multiple parallel worlds. In the end, we briefly summarize the concrete results obtained with the method.
Formal Concept Analysis for Information Retrieval
Qadi, Abderrahim El; Aboutajedine, Driss; Ennouary, Yassine
2010-01-01
In this paper we describe a mechanism to improve Information Retrieval (IR) on the web. The method is based on Formal Concepts Analysis (FCA) that it is makes semantical relations during the queries, and allows a reorganizing, in the shape of a lattice of concepts, the answers provided by a search engine. We proposed for the IR an incremental algorithm based on Galois lattice. This algorithm allows a formal clustering of the data sources, and the results which it turns over are classified by ...
A formalization of the flutter shutter
Tendero, Yohann; Rougé, Bernard; Morel, Jean-Michel
2012-09-01
Acquiring good quality images of moving objects by a digital camera remains a valid question. If the velocity of the photographed object is not known, it is virtually impossible to tune an optimal exposure time. For this reason the recent Agrawal et al. flutter shutter apparatus has generated much interest. In this communication, we propose a mathematical formalization of a general flutter shutter method, also permitting non-binary shutter sequences. Thanks to this formalization, the question of the optimal flutter shutter code can be defined and solved. The method gives analytic formulas for the best attainable SNR for the restored image. It also gives a way to compute optimal flutter shutter codes.
Formal Institutions and Subjective Well-Being
DEFF Research Database (Denmark)
Bjørnskov, Christian; Dreher, Axel; Fischer, Justina
A long tradition in economics explores the association between the quality of formal institutions and economic performance. The literature on the relationship between such institutions and happiness is, however, rather limited. In this paper, we revisit the findings from recent cross-country stud......A long tradition in economics explores the association between the quality of formal institutions and economic performance. The literature on the relationship between such institutions and happiness is, however, rather limited. In this paper, we revisit the findings from recent cross...
Improved formalism for precision Higgs coupling fits
Energy Technology Data Exchange (ETDEWEB)
Barklow, Tim; Peskin, Michael E. [Stanford Univ., Menlo Park, CA (United States). Stanford Linear Accelerator Center; Fujii, Keisuke; Ogawa, Tomohisa [High Energy Accelerator Research Organization (KEK), Tsukuba, Ibaraki (Japan); Jung, Sunghoon [Stanford Univ., Menlo Park, CA (United States). Stanford Linear Accelerator Center; Seoul National Univ. (Korea, Republic of). Dept. of Physics and Astronomy; Karl, Robert; List, Jenny [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Tian, Junping [Tokyo Univ. (Japan). International Center for Elementary Particle Physics (ICEPP)
2017-08-15
Future e{sup +}e{sup -} colliders give the promise of model-independent determinations of the couplings of the Higgs boson. In this paper, we present an improved formalism for extracting Higgs boson couplings from e{sup +}e{sup -} data, based on the Effective Field Theory description of corrections to the Standard Model. We apply this formalism to give projections of Higgs coupling accuracies for stages of the International Linear Collider and for other proposed e{sup +}e{sup -} colliders.
A Mathematical Account of the NEGF Formalism
DEFF Research Database (Denmark)
Cornean, Decebal Horia; Moldoveanu, Valeriu; Pillet, Claude-Alain
2018-01-01
The main goal of this paper is to put on solid mathematical grounds the so-called non-equilibrium Green’s function transport formalism for open systems. In particular, we derive the Jauho–Meir–Wingreen formula for the time-dependent current through an interacting sample coupled to non-interacting......The main goal of this paper is to put on solid mathematical grounds the so-called non-equilibrium Green’s function transport formalism for open systems. In particular, we derive the Jauho–Meir–Wingreen formula for the time-dependent current through an interacting sample coupled to non...
Towards formalization of inspection using petrinets
International Nuclear Information System (INIS)
Javed, M.; Naeem, M.; Bahadur, F.; Wahab, A.
2014-01-01
Achieving better quality software has always been a challenge for software developers. Inspection is one of the most efficient techniques, which ensure the quality of software during its development. To the best of our knowledge, current inspection techniques are not realized by any formal approach. In this paper, we propose an inspection technique, which is not only backed by the formal mathematical semantics of Petri nets, but also supports inspecting concurrent processes. We also use a case study of an agent based distributed processing system to demonstrate the inspection of concurrent processes. (author)
Keldysh formalism for multiple parallel worlds
Energy Technology Data Exchange (ETDEWEB)
Ansari, M.; Nazarov, Y. V., E-mail: y.v.nazarov@tudelft.nl [Delft University of Technology, Kavli Institute of Nanoscience (Netherlands)
2016-03-15
We present a compact and self-contained review of the recently developed Keldysh formalism for multiple parallel worlds. The formalism has been applied to consistent quantum evaluation of the flows of informational quantities, in particular, to the evaluation of Renyi and Shannon entropy flows. We start with the formulation of the standard and extended Keldysh techniques in a single world in a form convenient for our presentation. We explain the use of Keldysh contours encompassing multiple parallel worlds. In the end, we briefly summarize the concrete results obtained with the method.
Tignanelli, H.
Se comentan en esta comunicación, las principales contribuciones realizadas en el campo de la educación en astronomía en los niveles primario, secundario y terciario, como punto de partida para la discusión de la actual inserción de los contenidos astronómicos en los nuevos contenidos curriculares de la EGB - Educación General Básica- y Polimodal, de la Reforma Educativa. En particular, se discuten los alcances de la educación formal y no formal, su importancia para la capacitación de profesores y maestros, y perspectivas a futuro.
Gutiérrez-Santiuste, Elba; Gámiz-Sánchez, Vanesa-M.; Gutiérrez-Pérez, Jose
2015-01-01
The study presents a comparative analysis of two virtual learning formats: one non-formal through a Massive Open Online Course (MOOC) and the other formal through b-learning. We compare the communication barriers and the satisfaction perceived by the students (N = 249) by developing a qualitative analysis using semi-structured questionnaires and…
Augmenting Reality and Formality of Informal and Non-Formal Settings to Enhance Blended Learning
Pérez-Sanagustin, Mar; Hernández-Leo, Davinia; Santos, Patricia; Kloos, Carlos Delgado; Blat, Josep
2014-01-01
Visits to museums and city tours have been part of higher and secondary education curriculum activities for many years. However these activities are typically considered "less formal" when compared to those carried out in the classroom, mainly because they take place in informal or non-formal settings. Augmented Reality (AR) technologies…
Cameron, Roslyn; Harrison, Jennifer L.
2012-01-01
Definitions, differences and relationships between formal, non-formal and informal learning have long been contentious. There has been a significant change in language and reference from adult education to what amounts to forms of learning categorised by their modes of facilitation. Nonetheless, there is currently a renewed interest in the…
Radovic, Slaviša; Passey, Don
2016-01-01
The aim of this paper is to explore further an under-developed area--how drivers of curriculum, pedagogy and assessment conceptions and practices shape the creation and uses of technologically based resources to support mathematics learning across informal, non-formal and formal learning environments. The paper considers: the importance of…
Combining Formal, Non-Formal and Informal Learning for Workforce Skill Development
Misko, Josie
2008-01-01
This literature review, undertaken for Australian Industry Group, shows how multiple variations and combinations of formal, informal and non-formal learning, accompanied by various government incentives and organisational initiatives (including job redesign, cross-skilling, multi-skilling, diversified career pathways, action learning projects,…
Lending Policies of Informal, Formal, and Semi-formal Lenders: Evidence from Vietnam
Lensink, B.W.; Pham, T.T.T.
2007-01-01
This paper compares lending policies of formal, informal and semiformal lenders with respect to household lending in Vietnam. The analysis suggests that the probability of using formal or semiformal credit increases if borrowers provide collateral, a guarantor and/or borrow for business-related
DNA methylation in metabolic disorders
DEFF Research Database (Denmark)
Barres, Romain; Zierath, Juleen R
2011-01-01
DNA methylation is a major epigenetic modification that controls gene expression in physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are associated with profound alterations in gene expression that are caused by genetic and environmental factors. Recent reports...... have provided evidence that environmental factors at all ages could modify DNA methylation in somatic tissues, which suggests that DNA methylation is a more dynamic process than previously appreciated. Because of the importance of lifestyle factors in metabolic disorders, DNA methylation provides...... a mechanism by which environmental factors, including diet and exercise, can modify genetic predisposition to disease. This article considers the current evidence that defines a role for DNA methylation in metabolic disorders....
Incremental guideline formalization with tool support
Serban, Radu; Puig-Centelles, Anna; ten Teije, Annette
2006-01-01
Guideline formalization is recognized as an important component in improving computerized guidelines, which in turn leads to better informedness, lower inter-practician variability and, ultimately, to higher quality healthcare. By means of a modeling exercise, we investigate the role of guideline
Maintaining formal models of living guidelines efficiently
Seyfang, Andreas; Martínez-Salvador, Begoña; Serban, Radu; Wittenberg, Jolanda; Miksch, Silvia; Marcos, Mar; Ten Teije, Annette; Rosenbrand, Kitty C J G M
2007-01-01
Translating clinical guidelines into formal models is beneficial in many ways, but expensive. The progress in medical knowledge requires clinical guidelines to be updated at relatively short intervals, leading to the term living guideline. This causes potentially expensive, frequent updates of the
A New Formalism for Relational Algebra
DEFF Research Database (Denmark)
Schwartzbach, Michael Ignatieff; Larsen, Kim Skak; Schmidt, Erik Meineche
1992-01-01
We present a new formalism for relational algebra, the FC language, which is based on a novel factorization of relations. The acronym stands for factorize and combine. A pure version of this language is equivalent to relational algebra in the sense that semantics preserving translations exist...
14 CFR 201.1 - Formal requirements.
2010-01-01
... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Formal requirements. 201.1 Section 201.1 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC... papers. (b) Any person desiring to provide air transportation as a commuter air carrier must comply with...
The Transition to Formal Thinking in Mathematics
Tall, David
2008-01-01
This paper focuses on the changes in thinking involved in the transition from school mathematics to formal proof in pure mathematics at university. School mathematics is seen as a combination of visual representations, including geometry and graphs, together with symbolic calculations and manipulations. Pure mathematics in university shifts…
Informal Science Learning in the Formal Classroom
Walsh, Lori; Straits, William
2014-01-01
In this article the authors share advice from the viewpoints of both a formal and informal educator that will help teachers identify the right Informal Science Institutions (ISIs)--institutions that specialize in learning that occurs outside of the school setting--to maximize their students' learning and use informal education to their…
Formal verification of algorithms for critical systems
Rushby, John M.; Von Henke, Friedrich
1993-01-01
We describe our experience with formal, machine-checked verification of algorithms for critical applications, concentrating on a Byzantine fault-tolerant algorithm for synchronizing the clocks in the replicated computers of a digital flight control system. First, we explain the problems encountered in unsynchronized systems and the necessity, and criticality, of fault-tolerant synchronization. We give an overview of one such algorithm, and of the arguments for its correctness. Next, we describe a verification of the algorithm that we performed using our EHDM system for formal specification and verification. We indicate the errors we found in the published analysis of the algorithm, and other benefits that we derived from the verification. Based on our experience, we derive some key requirements for a formal specification and verification system adequate to the task of verifying algorithms of the type considered. Finally, we summarize our conclusions regarding the benefits of formal verification in this domain, and the capabilities required of verification systems in order to realize those benefits.
Protocol design and implementation using formal methods
van Sinderen, Marten J.; Ferreira Pires, Luis; Pires, L.F.; Vissers, C.A.
1992-01-01
This paper reports on a number of formal methods that support correct protocol design and implementation. These methods are placed in the framework of a design methodology for distributed systems that was studied and developed within the ESPRIT II Lotosphere project (2304). The paper focuses on
Educational attainment, formal employment and contraceptives ...
African Journals Online (AJOL)
Based on this, the study examines educational attainment, formal employment and contraceptives practices among working women in Lagos State University. Survey design was adopted for the study. Using Stratified and simple random sampling techniques, quantitative data was gathered through the administration of ...
A Formal Model of Identity Mixer
DEFF Research Database (Denmark)
Camenisch, Jan; Mödersheim, Sebastian Alexander; Sommer, Dieter
2010-01-01
Identity Mixer is an anonymous credential system developed at IBM that allows users for instance to prove that they are over 18 years old without revealing their name or birthdate. This privacy-friendly tech- nology is realized using zero-knowledge proofs. We describe a formal model of Identity...
Simulation and formal analysis of visual attention
Bosse, T.; Maanen, P.P. van; Treur, J.
2009-01-01
In this paper a simulation model for visual attention is discussed and formally analysed. The model is part of the design of an agent-based system that supports a naval officer in its task to compile a tactical picture of the situation in the field. A case study is described in which the model is
A Formal Model For Declarative Workflows
DEFF Research Database (Denmark)
Mukkamala, Raghava Rao
it as a general formal model for specification and execution of declarative, event-based business processes, as a generalization of a concurrency model, the classic event structures. The model allows for an intuitive operational semantics and mapping of execution state by a notion of markings of the graphs and we...
Formal synthesis of naturally occurring norephedrine
Indian Academy of Sciences (India)
A concise and simple synthesis of 1-hydroxy-phenethylamine derivatives has been achieved following classical organic transformations using commercially available chiral pools. The said derivatives were explored for the synthesis of naturally occurring bio-active small molecules. Formal synthesis of norephedrine, virolin ...
Formalizing the Problem of Music Description
DEFF Research Database (Denmark)
Sturm, Bob L.; Bardeli, Rolf; Langlois, Thibault
2015-01-01
The lack of a formalism for “the problem of music descrip- tion” results in, among other things: ambiguity in what problem a music description system must address, how it should be evaluated, what criteria define its success, and the paradox that a music description system can reproduce the “ground...
A formal theory of the selfish gene.
Gardner, A; Welch, J J
2011-08-01
Adaptation is conventionally regarded as occurring at the level of the individual organism. In contrast, the theory of the selfish gene proposes that it is more correct to view adaptation as occurring at the level of the gene. This view has received much popular attention, yet has enjoyed only limited uptake in the primary research literature. Indeed, the idea of ascribing goals and strategies to genes has been highly controversial. Here, we develop a formal theory of the selfish gene, using optimization theory to capture the analogy of 'gene as fitness-maximizing agent' in mathematical terms. We provide formal justification for this view of adaptation by deriving mathematical correspondences that translate the optimization formalism into dynamical population genetics. We show that in the context of social interactions between genes, it is the gene's inclusive fitness that provides the appropriate maximand. Hence, genic selection can drive the evolution of altruistic genes. Finally, we use the formalism to assess the various criticisms that have been levelled at the theory of the selfish gene, dispelling some and strengthening others. © 2011 The Authors. Journal of Evolutionary Biology © 2011 European Society For Evolutionary Biology.
Rhythmic Characteristics of Colloquial and Formal Tamil
Keane, Elinor
2006-01-01
Application of recently developed rhythmic measures to passages of read speech in colloquial and formal Tamil revealed some significant differences between the two varieties, which are in diglossic distribution. Both were also distinguished from a set of control data from British English speakers reading an equivalent passage. The findings have…
Towards a Formal Framework for Computational Trust
DEFF Research Database (Denmark)
Nielsen, Mogens; Krukow, Karl Kristian; Sassone, Vladimiro
2006-01-01
We define a mathematical measure for the quantitative comparison of probabilistic computational trust systems, and use it to compare a well-known class of algorithms based on the so-called beta model. The main novelty is that our approach is formal, rather than based on experimental simulation....
Informal and Formal Learning of General Practitioners
Spaan, Nadia Roos; Dekker, Anne R. J.; van der Velden, Alike W.; de Groot, Esther
2016-01-01
Purpose: The purpose of this study is to understand the influence of formal learning from a web-based training and informal (workplace) learning afterwards on the behaviour of general practitioners (GPs) with respect to prescription of antibiotics. Design/methodology/approach: To obtain insight in various learning processes, semi-structured…
Informal and formal learning of general practitioners
Spaan, Nadia Roos; Dekker, Anne R. J.; van der Velden, Alike W.; de Groot, Esther
2016-01-01
Purpose The purpose of this study is to understand the influence of formal learning from a web-based training and informal (workplace) learning afterwards on the behaviour of general practitioners (GPs) with respect to prescription of antibiotics. Design/methodology/approach To obtain insight in
Revisiting the formal foundation of Probabilistic Databases
Wanders, B.; van Keulen, Maurice
2015-01-01
One of the core problems in soft computing is dealing with uncertainty in data. In this paper, we revisit the formal foundation of a class of probabilistic databases with the purpose to (1) obtain data model independence, (2) separate metadata on uncertainty and probabilities from the raw data, (3)
On the Need for Practical Formal Methods
1998-01-01
additional research and engineering that is needed to make the current set of formal methods more practical. To illustrate the ideas, I present several exam ...either a good violin or a highly talented violinist. Light-weight techniques o er software developers good violins . A user need not be a talented
The formal path integral and quantum mechanics
International Nuclear Information System (INIS)
Johnson-Freyd, Theo
2010-01-01
Given an arbitrary Lagrangian function on R d and a choice of classical path, one can try to define Feynman's path integral supported near the classical path as a formal power series parameterized by 'Feynman diagrams', although these diagrams may diverge. We compute this expansion and show that it is (formally, if there are ultraviolet divergences) invariant under volume-preserving changes of coordinates. We prove that if the ultraviolet divergences cancel at each order, then our formal path integral satisfies a 'Fubini theorem' expressing the standard composition law for the time evolution operator in quantum mechanics. Moreover, we show that when the Lagrangian is inhomogeneous quadratic in velocity such that its homogeneous-quadratic part is given by a matrix with constant determinant, then the divergences cancel at each order. Thus, by 'cutting and pasting' and choosing volume-compatible local coordinates, our construction defines a Feynman-diagrammatic 'formal path integral' for the nonrelativistic quantum mechanics of a charged particle moving in a Riemannian manifold with an external electromagnetic field.
Moving interprofessional learning forward through formal assessment.
Stone, Judy
2010-04-01
There is increasing agreement that graduates who finish tertiary education with the full complement of skills and knowledge required for their designated profession are not 'work-ready' unless they also acquire interpersonal, collaborative practice and team-working capabilities. Health workers are unable to contribute to organisational culture in a positive way unless they too attain these capabilities. These capabilities have been shown to improve health care in terms of patient safety, worker satisfaction and health service efficiency. Given the importance of interprofessional learning (IPL) which seeks to address these capabilities, why is IPL not consistently embedded into the education of undergraduates, postgraduates and vocationally qualified personnel through formal assessment? This paper offers an argument for the formal assessment of IPL. It illustrates how the interests of the many stakeholders in IPL can benefit from, and contribute to, the integration of IPL into mainstream professional development and tertiary education. It offers practical examples of assessment in IPL which could drive learning and offer authentic, contextual teaching and learning experiences to undergraduates and health workers alike. Assessment drives learning and without formal assessment IPL will continue to be viewed as an optional topic of little relative importance for learners. In order to make the next step forward, IPL needs to be recognised and endorsed through formal assessment, both at the tertiary education level and within the workplace environment. This is supported by workforce initiatives and tertiary education policy which can be used to specify the capabilities or generic skills necessary for effective teamwork and collaborative practice.
What makes industries believe in formal methods
Vissers, C.A.; van Sinderen, Marten J.; Ferreira Pires, Luis; Pires, L.F.; Danthine, A.S.; Leduc, G.; Wolper, P.
1993-01-01
The introduction of formal methods in the design and development departments of an industrial company has far reaching and long lasting consequences. In fact it changes the whole environment of methods, tools and skills that determine the design culture of that company. A decision to replace current
Confusion about entrepreneurship? Formal versus informal small ...
African Journals Online (AJOL)
chestt
that contributes to both business formation and the ultimate expansion or growth of the business. The entrepreneurial actions related to these business activities are analysed in this study. The differential application of these actions in the formal and informal business panels is of particular importance for this study. Although ...
Formally analysing the concepts of domestic violence
Poelmans, J.; Elzinga, P.; Viaene, S.; Dedene, G.
2011-01-01
The types of police inquiries performed these days are incredibly diverse. Often data processing architectures are not suited to cope with this diversity since most of the case data is still stored as unstructured text. In this paper Formal Concept Analysis (FCA) is showcased for its exploratory
Formal and Applied Counseling in Israel
Israelashvili, Moshe; Wegman-Rozi, Orit
2012-01-01
Living in Israel is intensive and demanding but also meaningful and exciting. This article addresses the gap between the narrowly defined formal status of counseling in Israel and the widespread occurrence of counseling in various settings. It is argued that several recent changes, especially in the definition of treatment, along with the…
A formal model for total quality management
S.C. van der Made-Potuijt; H.B. Bertsch (Boudewijn); L.P.J. Groenewegen
1996-01-01
textabstractTotal Quality Management (TQM) is a systematic approach to managing a company. TQM is systematic in the sense that it is uses facts through observation, analysis and measurable goals. There are theoretical descriptions of this management concept, but there is no formal model of it. A
Electric current arising from unpolarized polyvinyl formal
Indian Academy of Sciences (India)
Unknown
An appreciable electric current is observed in a system consisting of a polyvinyl formal (PVF) film in a sandwich ... Electric current; open circuit voltage; water activated phenomenon; plasticization effect. 1. Introduction ... either the trapping parameters or the distribution of the ..... For this reason contact potential drop between.
Formal specifications for safety grade systems
International Nuclear Information System (INIS)
Chisholm, G.H.; Smith, B.T.; Wojcik, A.S.
1992-01-01
The authors describe the findings of a study into the application of formal methods to the specification of a safety system for an operating nuclear reactor. They developed a formal specification that is used to verify and validate that no unsafe condition will result from action or inaction of the system. For this reason, the specification must facilitate thinking about, talking about, and implementing the system. In fact, the specification must provide a bridge between people (designers, engineers, policy makers) and diverse implementations (hardware, software, sensors, power supplies) at all levels. For a specification to serve as an effective linkage, it must have the following properties: (1) completeness, (2) conciseness, (3) unambiguity, and (4) communicativeness. In this paper they describe the development of a specification that has three properties. This development is based on the use of formal methods, i.e., methods that add mathematical rigor to the development, analysis and operation of computer systems and to applications based thereon (Neumann). They demonstrate that a specification derived from a formal basis facilitates development of the design and its subsequent verification
A Formal Model for Context-Awareness
DEFF Research Database (Denmark)
Kjærgaard, Mikkel Baun; Bunde-Pedersen, Jonathan
here is a definite lack of formal support for modeling real- istic context-awareness in pervasive computing applications. The Conawa calculus presented in this paper provides mechanisms for modeling complex and interwoven sets of context-information by extending ambient calculus with new construc...
Formal system of communication and understanding. II
Energy Technology Data Exchange (ETDEWEB)
Zsuzsanna, M
1982-01-01
For pt.I see IBID., no.5, p.252-8 (1982). In this article G. Pask's (1975) formal theory of dialogues and talk is summarized. Part II describes the talk-environment and modelling. The conscious systems and machine-intelligence are mainly dealt with. Finally a couple of cases with Pask's theory implemented are looked at. 7 references.
Formal truncations of connected kernel equations
International Nuclear Information System (INIS)
Dixon, R.M.
1977-01-01
The Connected Kernel Equations (CKE) of Alt, Grassberger and Sandhas (AGS); Kouri, Levin and Tobocman (KLT); and Bencze, Redish and Sloan (BRS) are compared against reaction theory criteria after formal channel space and/or operator truncations have been introduced. The Channel Coupling Class concept is used to study the structure of these CKE's. The related wave function formalism of Sandhas, of L'Huillier, Redish and Tandy and of Kouri, Krueger and Levin are also presented. New N-body connected kernel equations which are generalizations of the Lovelace three-body equations are derived. A method for systematically constructing fewer body models from the N-body BRS and generalized Lovelace (GL) equations is developed. The formally truncated AGS, BRS, KLT and GL equations are analyzed by employing the criteria of reciprocity and two-cluster unitarity. Reciprocity considerations suggest that formal truncations of BRS, KLT and GL equations can lead to reciprocity-violating results. This study suggests that atomic problems should employ three-cluster connected truncations and that the two-cluster connected truncations should be a useful starting point for nuclear systems
Formal Method of Description Supporting Portfolio Assessment
Morimoto, Yasuhiko; Ueno, Maomi; Kikukawa, Isao; Yokoyama, Setsuo; Miyadera, Youzou
2006-01-01
Teachers need to assess learner portfolios in the field of education. However, they need support in the process of designing and practicing what kind of portfolios are to be assessed. To solve the problem, a formal method of describing the relations between the lesson forms and portfolios that need to be collected and the relations between…
Formal demography of families and households
Willekens, F.J.; van Imhoff, E.; Wright, James D.
2015-01-01
‘Family and household demography’ differs from traditional demography in that it explicitly recognizes and studies relationships between individuals. Formal demography focuses on the definition and measurement of families and households, and modeling of types, number, and composition of families and
Ontology Assisted Formal Specification Extraction from Text
Directory of Open Access Journals (Sweden)
Andreea Mihis
2010-12-01
Full Text Available In the field of knowledge processing, the ontologies are the most important mean. They make possible for the computer to understand better the natural language and to make judgments. In this paper, a method which use ontologies in the semi-automatic extraction of formal specifications from a natural language text is proposed.
Concepciones acerca de la maternidad en la educación formal y no formal
Directory of Open Access Journals (Sweden)
Alvarado Calderón, Kathia
2005-06-01
Full Text Available Este artículo presenta algunos resultados de la investigación desarrollada en el Instituto de Investigación en Educación (INIE, bajo el nombre "Construcción del concepto de maternidad en la educación formal y no formal". Utilizando un enfoque cualitativo de investigación, recurrimos a las técnicas de elaboración de dibujos, entrevistas y grupo focal como recursos para la recolección de la información. De esta manera, podemos acercarnos a las concepciones de la maternidad que utilizan los participantes de las diferentes instancias educativas (formal y no formal con quienes se trabajó. This article presents some results the research developed in the Instituto de Investigación en Educación (INIE, named "Construcción del concepto de maternidad en la educación formal y no formal". It begins with a theoretical analysis about social conceptions regarding motherhood in the occidental societies. Among the techniques for gathering information were thematic drawing, interview and focus group, using a qualitative approach research method. This is followed by a brief summary of main findings. The article concludes with a proposal of future working lines for the deconstruction of the motherhood concept in formal and informal education contexts.
20 CFR 702.336 - Formal hearings; new issues.
2010-04-01
... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Formal hearings; new issues. 702.336 Section... Procedures Formal Hearings § 702.336 Formal hearings; new issues. (a) If, during the course of the formal hearing, the evidence presented warrants consideration of an issue or issues not previously considered...
A Survey of Formal Methods in Software Development
DEFF Research Database (Denmark)
Bjørner, Dines
2012-01-01
The use of formal methods and formal techniques in industry is steadily growing. In this survey we shall characterise what we mean by software development and by a formal method; briefly overview a history of formal specification languages - some of which are: VDM (Vienna Development Method, 1974...... need for multi-language formalisation (Petri Nets, MSC, StateChart, Temporal Logics); the sociology of university and industry acceptance of formal methods; the inevitability of the use of formal software development methods; while referring to seminal monographs and textbooks on formal methods....
Y-formalism and b ghost in the non-minimal pure spinor formalism of superstrings
International Nuclear Information System (INIS)
Oda, Ichiro; Tonin, Mario
2007-01-01
We present the Y-formalism for the non-minimal pure spinor quantization of superstrings. In the framework of this formalism we compute, at the quantum level, the explicit form of the compound operators involved in the construction of the b ghost, their normal-ordering contributions and the relevant relations among them. We use these results to construct the quantum-mechanical b ghost in the non-minimal pure spinor formalism. Moreover we show that this non-minimal b ghost is cohomologically equivalent to the non-covariant b ghost
Methylation-Specific PCR Unraveled
Directory of Open Access Journals (Sweden)
Sarah Derks
2004-01-01
Full Text Available Methylation‐specific PCR (MSP is a simple, quick and cost‐effective method to analyze the DNA methylation status of virtually any group of CpG sites within a CpG island. The technique comprises two parts: (1 sodium bisulfite conversion of unmethylated cytosine's to uracil under conditions whereby methylated cytosines remains unchanged and (2 detection of the bisulfite induced sequence differences by PCR using specific primer sets for both unmethylated and methylated DNA. This review discusses the critical parameters of MSP and presents an overview of the available MSP variants and the (clinical applications.
Generalizing Prototype Theory: A Formal Quantum Framework
Aerts, Diederik; Broekaert, Jan; Gabora, Liane; Sozzo, Sandro
2016-01-01
Theories of natural language and concepts have been unable to model the flexibility, creativity, context-dependence, and emergence, exhibited by words, concepts and their combinations. The mathematical formalism of quantum theory has instead been successful in capturing these phenomena such as graded membership, situational meaning, composition of categories, and also more complex decision making situations, which cannot be modeled in traditional probabilistic approaches. We show how a formal quantum approach to concepts and their combinations can provide a powerful extension of prototype theory. We explain how prototypes can interfere in conceptual combinations as a consequence of their contextual interactions, and provide an illustration of this using an intuitive wave-like diagram. This quantum-conceptual approach gives new life to original prototype theory, without however making it a privileged concept theory, as we explain at the end of our paper. PMID:27065436
The formal logic of business rules
Directory of Open Access Journals (Sweden)
Ivana Rábová
2007-01-01
Full Text Available Identification of improvement areas and utilization of information and communication technologies have gained value and priority in our knowledge driven society. Rules define constraints, conditions and policies of how the business processes are to be performed but they also affect the behavior of the resource and facilitate strategic business goals achieving. They control the business and represent business knowledge. The research works about business rules show how to specify and classify business rules from the business perspective and to establish an approach to managing them that will enable faster change in business processes and other business concepts in all areas of the business. In concrete this paper deals with four approaches to business rules formalization, i. e. notation of OCL, inference rules, decision table and predicate logic and with their general evaluation. The article shows also the advantages and disadvantages of these approaches of formalization. They are the example of every mentioned approach.
Viscous warm inflation: Hamilton-Jacobi formalism
Akhtari, L.; Mohammadi, A.; Sayar, K.; Saaidi, Kh.
2017-04-01
Using Hamilton-Jacobi formalism, the scenario of warm inflation with viscous pressure is considered. The formalism gives a way of computing the slow-rolling parameter without extra approximation, and it is well-known as a powerful method in cold inflation. The model is studied in detail for three different cases of the dissipation and bulk viscous pressure coefficients. In the first case where both coefficients are taken as constant, it is shown that the case could not portray warm inflationary scenario compatible with observational data even it is possible to restrict the model parameters. For other cases, the results shows that the model could properly predicts the perturbation parameters in which they stay in perfect agreement with Planck data. As a further argument, r -ns and αs -ns are drown that show the acquired result could stand in acceptable area expressing a compatibility with observational data.
Comparing formal verification approaches of interlocking systems
DEFF Research Database (Denmark)
Haxthausen, Anne Elisabeth; Nguyen, Hoang Nga; Roggenbach, Markus
2016-01-01
these approaches. As a first step towards this, in this paper we suggest a way to compare different formal approaches for verifying designs of route-based interlocking systems and we demonstrate it on modelling and verification approaches developed within the research groups at DTU/Bremen and at Surrey......The verification of railway interlocking systems is a challenging task, and therefore several research groups have suggested to improve this task by using formal methods, but they use different modelling and verification approaches. To advance this research, there is a need to compare....../Swansea. The focus is on designs that are specified by so-called control tables. The paper can serve as a starting point for further comparative studies. The DTU/Bremen research has been funded by the RobustRailS project granted by Innovation Fund Denmark. The Surrey/Swansea research has been funded by the Safe...
A Formal Framework for Workflow Analysis
Cravo, Glória
2010-09-01
In this paper we provide a new formal framework to model and analyse workflows. A workflow is the formal definition of a business process that consists in the execution of tasks in order to achieve a certain objective. In our work we describe a workflow as a graph whose vertices represent tasks and the arcs are associated to workflow transitions. Each task has associated an input/output logic operator. This logic operator can be the logical AND (•), the OR (⊗), or the XOR -exclusive-or—(⊕). Moreover, we introduce algebraic concepts in order to completely describe completely the structure of workflows. We also introduce the concept of logical termination. Finally, we provide a necessary and sufficient condition for this property to hold.
Generalizing Prototype Theory: A Formal Quantum Framework
Directory of Open Access Journals (Sweden)
Diederik eAerts
2016-03-01
Full Text Available Theories of natural language and concepts have been unable to model the flexibility, creativity, context-dependence, and emergence, exhibited by words, concepts and their combinations. The mathematical formalism of quantum theory has instead been successful in capturing these phenomena such as graded membership, situational meaning, composition of categories, and also more complex decision making situations, which cannot be modeled in traditional probabilistic approaches. We show how a formal quantum approach to concepts and their combinations can provide a powerful extension of prototype theory. We explain how prototypes can interfere in conceptual combinations as a consequence of their contextual interactions, and provide an illustration of this using an intuitive wave-like diagram. This quantum-conceptual approach gives new life to original prototype theory, without however making it a privileged concept theory, as we explain at the end of our paper.
Formal Definition of Measures for BPMN Models
Reynoso, Luis; Rolón, Elvira; Genero, Marcela; García, Félix; Ruiz, Francisco; Piattini, Mario
Business process models are currently attaining more relevance, and more attention is therefore being paid to their quality. This situation led us to define a set of measures for the understandability of BPMN models, which is shown in a previous work. We focus on understandability since a model must be well understood before any changes are made to it. These measures were originally informally defined in natural language. As is well known, natural language is ambiguous and may lead to misunderstandings and a misinterpretation of the concepts captured by a measure and the way in which the measure value is obtained. This has motivated us to provide the formal definition of the proposed measures using OCL (Object Constraint Language) upon the BPMN (Business Process Modeling Notation) metamodel presented in this paper. The main advantages and lessons learned (which were obtained both from the current work and from previous works carried out in relation to the formal definition of other measures) are also summarized.
Formalism and physical interpretation in Schroedinger
International Nuclear Information System (INIS)
Paty, M.
1992-01-01
The question of the relation between a formalism and its physical interpretation arises not only when theoretical and conceptual systems are reorganized, but in the theoretical elaboration as well. The Schroedinger's work and thought are examined in this paper with this double concern. His work on the mathematical formalism is constantly sustained by a proper physical thought which takes the form of a wave intuition that guarantees him intelligibility. Concerning his interpretation of quantum mechanics, his thought remains characterized, through its evolution, by a w ave image of the world . The way he deals with space-time structure in General Relativity and favours the possibility of a direct interpretation of space-time geometrical quantities, is also studied. (author). 75 refs
Picture languages formal models for picture recognition
Rosenfeld, Azriel
1979-01-01
Computer Science and Applied Mathematics: Picture Languages: Formal Models for Picture Recognition treats pictorial pattern recognition from the formal standpoint of automata theory. This book emphasizes the capabilities and relative efficiencies of two types of automata-array automata and cellular array automata, with respect to various array recognition tasks. The array automata are simple processors that perform sequences of operations on arrays, while the cellular array automata are arrays of processors that operate on pictures in a highly parallel fashion, one processor per picture element. This compilation also reviews a collection of results on two-dimensional sequential and parallel array acceptors. Some of the analogous one-dimensional results and array grammars and their relation to acceptors are likewise covered in this text. This publication is suitable for researchers, professionals, and specialists interested in pattern recognition and automata theory.
$\\delta N$ formalism from superpotential and holography
Garriga, Jaume; Vernizzi, Filippo
2016-02-16
We consider the superpotential formalism to describe the evolution of scalar fields during inflation, generalizing it to include the case with non-canonical kinetic terms. We provide a characterization of the attractor behaviour of the background evolution in terms of first and second slow-roll parameters (which need not be small). We find that the superpotential is useful in justifying the separate universe approximation from the gradient expansion, and also in computing the spectra of primordial perturbations around attractor solutions in the $\\delta N$ formalism. As an application, we consider a class of models where the background trajectories for the inflaton fields are derived from a product separable superpotential. In the perspective of the holographic inflation scenario, such models are dual to a deformed CFT boundary theory, with $D$ mutually uncorrelated deformation operators. We compute the bulk power spectra of primordial adiabatic and entropy cosmological perturbations, and show that the results...
Measurements and mathematical formalism of quantum mechanics
Slavnov, D. A.
2007-03-01
A scheme for constructing quantum mechanics is given that does not have Hilbert space and linear operators as its basic elements. Instead, a version of algebraic approach is considered. Elements of a noncommutative algebra (observables) and functionals on this algebra (elementary states) associated with results of single measurements are used as primary components of the scheme. On the one hand, it is possible to use within the scheme the formalism of the standard (Kolmogorov) probability theory, and, on the other hand, it is possible to reproduce the mathematical formalism of standard quantum mechanics, and to study the limits of its applicability. A short outline is given of the necessary material from the theory of algebras and probability theory. It is described how the mathematical scheme of the paper agrees with the theory of quantum measurements, and avoids quantum paradoxes.
Flexible receiver adapter formal design review
International Nuclear Information System (INIS)
Krieg, S.A.
1995-01-01
This memo summarizes the results of the Formal (90%) Design Review process and meetings held to evaluate the design of the Flexible Receiver Adapters, support platforms, and associated equipment. The equipment is part of the Flexible Receiver System used to remove, transport, and store long length contaminated equipment and components from both the double and single-shell underground storage tanks at the 200 area tank farms
Formal education in outdoor studies: introduction
Prince, Heather
2015-01-01
Regional cultural perspectives involve outdoor studies in different ways in formal curricula. This section focuses on Western Europe, particularly the UK and Scandinavia, although also has a more international reach in Backman’s consideration of the training of teachers and in place-responsive teaching as described by Mannion and Lynch. ‘Outdoor studies’ is not seen in curricula per se but under various more specialised aspects such as outdoor play, outdoor learning, environmental education, ...
Heuristics structure and pervade formal risk assessment.
MacGillivray, Brian H
2014-04-01
Lay perceptions of risk appear rooted more in heuristics than in reason. A major concern of the risk regulation literature is that such "error-strewn" perceptions may be replicated in policy, as governments respond to the (mis)fears of the citizenry. This has led many to advocate a relatively technocratic approach to regulating risk, characterized by high reliance on formal risk and cost-benefit analysis. However, through two studies of chemicals regulation, we show that the formal assessment of risk is pervaded by its own set of heuristics. These include rules to categorize potential threats, define what constitutes valid data, guide causal inference, and to select and apply formal models. Some of these heuristics lay claim to theoretical or empirical justifications, others are more back-of-the-envelope calculations, while still more purport not to reflect some truth but simply to constrain discretion or perform a desk-clearing function. These heuristics can be understood as a way of authenticating or formalizing risk assessment as a scientific practice, representing a series of rules for bounding problems, collecting data, and interpreting evidence (a methodology). Heuristics are indispensable elements of induction. And so they are not problematic per se, but they can become so when treated as laws rather than as contingent and provisional rules. Pitfalls include the potential for systematic error, masking uncertainties, strategic manipulation, and entrenchment. Our central claim is that by studying the rules of risk assessment qua rules, we develop a novel representation of the methods, conventions, and biases of the prior art. © 2013 Society for Risk Analysis.
Formal conditions for the significance-effect
DEFF Research Database (Denmark)
Thellefsen, Torkild Leo; Sørensen, Bent; Thellefsen, Martin
2006-01-01
The significance-effect is the right effect of meaning caused upon an interpreting mind. The right effect is understood as the right interpretation of an intended meaning caused by a sign communicated by an utterer. In the article, which is inspired by Charles S. Peirce's doctrine of signs, his s...... semeiotics and his theory of communication, we account for the formal conditions that have to be present for the release of the significance-effect....
Consistency Anchor Formalization and Correctness Proofs
Miguel, Correia; Bessani, Alysson
2014-01-01
This is report contains the formal proofs for the techniques for increasing the consistency of cloud storage as presented in "Bessani et al. SCFS: A Cloud-backed File System. Proc. of the 2014 USENIX Annual Technical Conference. June 2014." The consistency anchor technique allows one to increase the consistency provided by eventually consistent cloud storage services like Amazon S3. This technique has been used in the SCFS (Shared Cloud File System) cloud-backed file system for solving rea...
Formal First Integrals of General Dynamical Systems
Directory of Open Access Journals (Sweden)
Jia Jiao
2016-01-01
Full Text Available The goal of this paper is trying to make a complete study on the integrability for general analytic nonlinear systems by first integrals. We will firstly give an exhaustive discussion on analytic planar systems. Then a class of higher dimensional systems with invariant manifolds will be considered; we will develop several criteria for existence of formal integrals and give some applications to illustrate our results at last.
Generalized formal model of Big Data
Shakhovska, N.; Veres, O.; Hirnyak, M.
2016-01-01
This article dwells on the basic characteristic features of the Big Data technologies. It is analyzed the existing definition of the “big data” term. The article proposes and describes the elements of the generalized formal model of big data. It is analyzed the peculiarities of the application of the proposed model components. It is described the fundamental differences between Big Data technology and business analytics. Big Data is supported by the distributed file system Google File System ...
DEFF Research Database (Denmark)
Bruun, Hans; Damm, F.; Dawes, J.
1998-01-01
This joint report from the Danish Institute for Applied Computer Science (IFAD), the Technical Universities of Delft and Denmark and the University of Leicester contains the background and technical material used in the production of the ISO Standard that defines the specification language part...... and reviewers of the project - these changes have improved the style and technical correctness of the formal definitions used to define VDM-SL....
A FORMALISM FOR FUZZY BUSINESS RULES
Directory of Open Access Journals (Sweden)
Vasile Mazilescu
2015-05-01
Full Text Available The aim of this paper is to provide a formalism for fuzzy rule bases, included in our prototype system FUZZY_ENTERPRISE. This framework can be used in Distributed Knowledge Management Systems (DKMSs, real-time interdisciplinary decision making systems, that often require increasing technical support to high quality decisions in a timely manner. The language of the first-degree predicates facilitates the formulation of complex knowledge in a rigorous way, imposing appropriate reasoning techniques.
Textile materials trading center formally launched online
Institute of Scientific and Technical Information of China (English)
无
2012-01-01
Textile materials trading center was formally launched online in Wuxi City,Jiangsu Province. This is the first third-party electronic trading platform for spot trading in China textile materials professional market. The project will strive to build the most influential textile materials trading center of East China,the whole country and even the whole world China textile materials trading center will be
Toward a Formal Model of Cognitive Synergy
Goertzel, Ben
2017-01-01
"Cognitive synergy" refers to a dynamic in which multiple cognitive processes, cooperating to control the same cognitive system, assist each other in overcoming bottlenecks encountered during their internal processing. Cognitive synergy has been posited as a key feature of real-world general intelligence, and has been used explicitly in the design of the OpenCog cognitive architecture. Here category theory and related concepts are used to give a formalization of the cognitive synergy concept....
On the formal series Witt transform
Moree, P.
2005-01-01
Given a formal power series f(z)∈C〚z〛f(z)∈C〚z〛 we define, for any positive integer r, its r th Witt transform, Wf(r), by Wf(r)(z)=1r∑d|rμ(d)f(zd)r/d, where μμ denotes the Möbius function. The Witt transform generalizes the necklace polynomials, M(α;n)M(α;n), that occur in the cyclotomic identity
Time delay in a multichannel formalism
International Nuclear Information System (INIS)
Haberzettl, Helmut; Workman, Ron
2007-01-01
We reexamine the time-delay formalism of Wigner, Eisenbud, and Smith, which was developed to analyze both elastic and inelastic resonances. An error in the paper of Smith has propagated through the literature. We correct this error and show how the results of Eisenbud and Smith are related. We also comment on some recent time-delay studies, based on Smith's erroneous interpretation of the Eisenbud result
Formalization and Analysis of Reasoning by Assumption
Bosse, T.; Jonker, C.M.; Treur, J.
2006-01-01
This article introduces a novel approach for the analysis of the dynamics of reasoning processes and explores its applicability for the reasoning pattern called reasoning by assumption. More specifically, for a case study in the domain of a Master Mind game, it is shown how empirical human reasoning traces can be formalized and automatically analyzed against dynamic properties they fulfill. To this end, for the pattern of reasoning by assumption a variety of dynamic properties have been speci...
Globalization and formal sector migration in Brazil
Aguayo-Tellez, Ernesto; Muendler, Marc-Andreas; Poole, Jennifer Pamela
2008-01-01
We use novel linked employer–employee data to study the relationship between globalization and formal sector interstate migration for Brazil. We estimate the worker’s multichoice migration problem and document that previously unobserved employer covariates are significant predictors associated with migration flows. Our results provide support for the idea that globalization acts on internal migration through the growth of employment opportunities at locations with a high concentration of fore...
Exploiting thesauri knowledge in medical guideline formalization
Serban, R.C.; ten Teije, A.C.M.
2009-01-01
Objectives: As in software product lifecycle, the effort spent in maintaining medical knowl edge in guidelines can be reduced, if modularization, formalization and tracking of domain knowledge are employed across the guideline development phases. Methods: We propose to exploit and combine knowledge templates with medical background knowledge from existing thesauri in order to produce reusable building blocks used in guideline development. These tem- plates enable easier guideline formalizatio...
Generalized operator canonical formalism and gauge invariance
International Nuclear Information System (INIS)
Fradkina, T.E.
1988-01-01
A direct proof is given in the functional representation of the invariance of the S-matrix constructed in the framework of the generalized operator canonical formalism. We find the traditional functional expression for the S-matrix (without point-splitting in the time factor) in the generalized phase space, as well as in the ghost configuration space. An explicit expression is obtained for the effective unitarizing Hamiltonian for gauge theories with constraints of arbitrary rank
Leslie Martin and the formal order
Directory of Open Access Journals (Sweden)
Jaime J. Ferrer Fores
2016-05-01
Full Text Available Abstract This paper analyzes the architecture of Sir Leslie Martin (1908-2000 and covers the intense professional career that starts with the Nursery School at Northwich, Cheshire (1937-1938 or the Alastair Morton house at Brampton (1938 which are ascribed to the orthodoxy of modern architecture, and continues with the projects he planned as the architect responsible of the railway company for stations and railroad infrastructure rearrangements in the postwar, interventions that will prepare him for his architectural maturity stage which he crystallizes in buildings for the Royal Festival Hall in London (1948-1951, the Harvey Court, Cambridge (1958-1962, the auditoriums for the Middleton Hall, University of Hull (1958 , the School of Music (1974 and College (1979 at Cambridge University and his proposal for the University of Bristol (1979 that illustrate the essential basis of his coherent architectural career where the tradition of modern architecture, the spatial continuity and the formal order converge. This analysis of the works in the fifties, sixties and seventies illustrates the architect’s constants through the chronological exploration of his works that reveal the compositional mechanisms, the search for formal order and the correct spatial organization taking into account the functional requirements, the relationship with the site and the technological resources that determine his entire career which is characterized by formal consistency and architectural coherence.
Nonextensive formalism and continuous Hamiltonian systems
International Nuclear Information System (INIS)
Boon, Jean Pierre; Lutsko, James F.
2011-01-01
A recurring question in nonequilibrium statistical mechanics is what deviation from standard statistical mechanics gives rise to non-Boltzmann behavior and to nonlinear response, which amounts to identifying the emergence of 'statistics from dynamics' in systems out of equilibrium. Among several possible analytical developments which have been proposed, the idea of nonextensive statistics introduced by Tsallis about 20 years ago was to develop a statistical mechanical theory for systems out of equilibrium where the Boltzmann distribution no longer holds, and to generalize the Boltzmann entropy by a more general function S q while maintaining the formalism of thermodynamics. From a phenomenological viewpoint, nonextensive statistics appeared to be of interest because maximization of the generalized entropy S q yields the q-exponential distribution which has been successfully used to describe distributions observed in a large class of phenomena, in particular power law distributions for q>1. Here we re-examine the validity of the nonextensive formalism for continuous Hamiltonian systems. In particular we consider the q-ideal gas, a model system of quasi-particles where the effect of the interactions are included in the particle properties. On the basis of exact results for the q-ideal gas, we find that the theory is restricted to the range q<1, which raises the question of its formal validity range for continuous Hamiltonian systems.
Formal refinement of extended state machines
Directory of Open Access Journals (Sweden)
Thomas Fayolle
2016-06-01
Full Text Available In a traditional formal development process, e.g. using the B method, the informal user requirements are (manually translated into a global abstract formal specification. This translation is especially difficult to achieve. The Event-B method was developed to incrementally and formally construct such a specification using stepwise refinement. Each increment takes into account new properties and system aspects. In this paper, we propose to couple a graphical notation called Algebraic State-Transition Diagrams (ASTD with an Event-B specification in order to provide a better understanding of the software behaviour. The dynamic behaviour is captured by the ASTD, which is based on automata and process algebra operators, while the data model is described by means of an Event-B specification. We propose a methodology to incrementally refine such specification couplings, taking into account new refinement relations and consistency conditions between the control specification and the data specification. We compare the specifications obtained using each approach for readability and proof complexity. The advantages and drawbacks of the traditional approach and of our methodology are discussed. The whole process is illustrated by a railway CBTC-like case study. Our approach is supported by tools for translating ASTD's into B and Event-B into B.
[How to write an article: formal aspects].
Corral de la Calle, M A; Encinas de la Iglesia, J
2013-06-01
Scientific research and the publication of the results of the studies go hand in hand. Exquisite research methods can only be adequately reflected in formal publication with the optimum structure. To ensure the success of this process, it is necessary to follow orderly steps, including selecting the journal in which to publish and following the instructions to authors strictly as well as the guidelines elaborated by diverse societies of editors and other institutions. It is also necessary to structure the contents of the article in a logical and attractive way and to use an accurate, clear, and concise style of language. Although not all the authors are directly involved in the actual writing, elaborating a scientific article is a collective undertaking that does not finish until the article is published. This article provides practical advice about formal and not-so-formal details to take into account when writing a scientific article as well as references that will help readers find more information in greater detail. Copyright © 2012 SERAM. Published by Elsevier Espana. All rights reserved.
Qualitative simulation in formal process modelling
International Nuclear Information System (INIS)
Sivertsen, Elin R.
1999-01-01
In relation to several different research activities at the OECD Halden Reactor Project, the usefulness of formal process models has been identified. Being represented in some appropriate representation language, the purpose of these models is to model process plants and plant automatics in a unified way to allow verification and computer aided design of control strategies. The present report discusses qualitative simulation and the tool QSIM as one approach to formal process models. In particular, the report aims at investigating how recent improvements of the tool facilitate the use of the approach in areas like process system analysis, procedure verification, and control software safety analysis. An important long term goal is to provide a basis for using qualitative reasoning in combination with other techniques to facilitate the treatment of embedded programmable systems in Probabilistic Safety Analysis (PSA). This is motivated from the potential of such a combination in safety analysis based on models comprising both software, hardware, and operator. It is anticipated that the research results from this activity will benefit V and V in a wide variety of applications where formal process models can be utilized. Examples are operator procedures, intelligent decision support systems, and common model repositories (author) (ml)
Naturally occurring methyl salicylate glycosides.
Mao, Ping; Liu, Zizhen; Xie, Meng; Jiang, Rui; Liu, Weirui; Wang, Xiaohong; Meng, Shen; She, Gaimei
2014-01-01
As an important part of non steroids anti-inflammation drug (NSAIDs), salicylate has developed from natural substance salicylic acid to natrium salicylicum, to aspirin. Now, methyl salicylate glycoside, a new derivative of salicylic acid, is modified with a -COOH group integrated one methyl radical into formic ether, and a -OH linked with a monosaccharide, a disaccharide or a trisaccharide unit by glycosidic linkage. It has the similar pharmacological activities, anti-inflammatory, analgesic, antipyretic and antithrombotic as the previous salicylates' without resulting in serious side effects, particularly the gastrointestinal toxicity. Owing to the superiority of those significant bioactivities, methyl salicylate glycosides have became a hot research area in NSAIDs for several years. This paper compiles all 9 naturally occurring methyl salicylate glycosides, their distribution of the resource and pharmacological mechanism, which could contribute to the new drug discovery.
Process for the production of methyl methacrylate
Eastham, G.R.; Johnson, D.W.; Straathof, A.J.J.; Fraaije, Marco; Winter, Remko
2015-01-01
A process of producing methyl methacrylate or derivatives thereof is described. The process includes the steps of; (i) converting 2-butanone to methyl propionate using a Baeyer-Villiger monooxygenase, and (ii) treating the methyl propionate produced to obtain methyl methacrylate or derivatives
Formalization of the Resolution Calculus for First-Order Logic
DEFF Research Database (Denmark)
Schlichtkrull, Anders
2016-01-01
A formalization in Isabelle/HOL of the resolution calculus for first-order logic is presented. Its soundness and completeness are formally proven using the substitution lemma, semantic trees, Herbrand’s theorem, and the lifting lemma. In contrast to previous formalizations of resolution, it consi......A formalization in Isabelle/HOL of the resolution calculus for first-order logic is presented. Its soundness and completeness are formally proven using the substitution lemma, semantic trees, Herbrand’s theorem, and the lifting lemma. In contrast to previous formalizations of resolution...
Formal specification is an experimental science
Energy Technology Data Exchange (ETDEWEB)
Bjorner, D. [Technical Univ., Lyngby (Denmark)
1992-09-01
Traditionally, abstract models of large, complex systems have been given in free-form mathematics, combining - often in ad-hoc, not formally supported ways - notions from the disciplines of partial differential equations, functional analysis, mathematical statistics, etc. Such models have been very useful for assimilation of information, analysis (investigation), and prediction (simulation). These models have, however, usually not been helpful in deriving computer representations of the modelled systems - for the purposes of computerized monitoring and control, Computing science, concerned with how to construct objects that can exist within the computer, offers ways of complementing, and in some cases, replacing or combining traditional mathematical models. Formal, model-, as well as property-oriented, specifications in the styles of denotational (respectively, algebraic semantics) represent major approaches to such modelling. In this expository, discursive paper we illustrate what we mean by model-oriented specifications of large, complex technological computing systems. The three modelling examples covers the introvert programming methodological subject of SDEs: software development environments, the distributed computing system subject of wfs`s: (transaction) work flow systems, and the extrovert subject of robots: robotics! the thesis is, just as for mathematical modelling, that we can derive much understanding, etc., from experimentally creating such formally specified models - on paper - and that we gain little in additionally building ad-hoc prototypes. Our models are expressed in a model-oriented style using the VDM specification language Meta-IV In this paper the models only reflect the {open_quotes}data modelling{close_quotes} aspects. We observe that such data models are more easily captured in the model-oriented siyle than in the algebraic semantics property-oriented style which originally was built of the abstraction of operations. 101 refs., 4 figs.
A formal mentorship program for faculty development.
Jackevicius, Cynthia A; Le, Jennifer; Nazer, Lama; Hess, Karl; Wang, Jeffrey; Law, Anandi V
2014-06-17
To describe the development, implementation, and evaluation of a formal mentorship program at a college of pharmacy. After extensive review of the mentorship literature within the health sciences, a formal mentorship program was developed between 2006 and 2008 to support and facilitate faculty development. The voluntary program was implemented after mentors received training, and mentors and protégés were matched and received an orientation. Evaluation consisted of conducting annual surveys and focus groups with mentors and protégés. Fifty-one mentor-protégé pairs were formed from 2009 to 2012. A large majority of the mentors (82.8%-96.9%) were satisfied with the mentorship program and its procedures. The majority of the protégés (≥70%) were satisfied with the mentorship program, mentor-protégé relationship, and program logistics. Both mentors and protégés reported that the protégés most needed guidance on time management, prioritization, and work-life balance. While there were no significant improvements in the proteges' number of grant submissions, retention rates, or success in promotion/tenure, the total number of peer-reviewed publications by junior faculty members was significantly higher after program implementation (mean of 7 per year vs 21 per year, p=0.03) in the college's pharmacy practice and administration department. A formal mentorship program was successful as measured by self-reported assessments of mentors and protégés.
Topological M Theory from Pure Spinor Formalism
Grassi, P A; Grassi, Pietro Antonio; Vanhove, Pierre
2005-01-01
We construct multiloop superparticle amplitudes in 11d using the pure spinor formalism. We explain how this construction reduces to the superparticle limit of the multiloop pure spinor superstring amplitudes prescription. We then argue that this construction points to some evidence for the existence of a topological M theory based on a relation between the ghost number of the full-fledged supersymmetric critical models and the dimension of the spacetime for topological models. In particular, we show that the extensions at higher orders of the previous results for the tree and one-loop level expansion for the superparticle in 11 dimensions is related to a topological model in 7 dimensions.
From Safety Analysis to Formal Specification
DEFF Research Database (Denmark)
Hansen, Kirsten Mark; Ravn, Anders P.; Stavridou, Victoria
1998-01-01
Software for safety critical systems must deal with the hazards identified bysafety analysis. This paper investigates, how the results of onesafety analysis technique, fault trees, are interpreted as software safetyrequirements to be used in the program design process. We propose thatfault tree...... analysis and program development use the samesystem model. This model is formalized in areal-time, interval logic, based on a conventional dynamic systems modelwith state evolving over time. Fault trees are interpreted astemporal formulas, and it is shown how such formulas can be usedfor deriving safety...
Aspects of the supersymmetric Goldstone formalism
International Nuclear Information System (INIS)
Lerche, W.
1985-01-01
The present thesis deal with the discussion of general properties of Goldstone excitations in global N=1 supersymmetric theories. The results can become relevant in the framework of theories which interpret quarks and leptons as composite 'quasi-Goldstone fermions'. The thesis is arranged in two main parts: the first is occupied by group-theoretical aspects, i.e. by the spectrum of supersymmetric Goldstone excitations as well as by geometrical considerations which are connected with effective Lagrangian densities. In the second main part dynamic questions like for instance mass generation are treated. For this a suitable formalism is developed. (orig.) [de
Noncommutative gauge theories and Kontsevich's formality theorem
International Nuclear Information System (INIS)
Jurco, B.; Schupp, P.; Wess, J.
2001-01-01
The equivalence of star products that arise from the background field with and without fluctuations and Kontsevich's formality theorem allow an explicitly construction of a map that relates ordinary gauge theory and noncommutative gauge theory (Seiberg-Witten map.) Using noncommutative extra dimensions the construction is extended to noncommutative nonabelian gauge theory for arbitrary gauge groups; as a byproduct we obtain a 'Mini Seiberg-Witten map' that explicitly relates ordinary abelian and nonabelian gauge fields. All constructions are also valid for non-constant B-field, and even more generally for any Poisson tensor
First formal ITER negotiations make excellent progress
International Nuclear Information System (INIS)
Barnard, P.
2001-01-01
November 8 and 9 2001 marked the historic beginning of formal negotiations meetings on the ITER project. Delegations from Canada, the European Union, Japan and the Russian Federation met in Toronto, Canada, for the first in a series of Negotiations that is expected to lead, by the end of 2002, to an agreement on the joint implementation of ITER. This agreement will govern, under international law, the construction, operation and decommissioning of ITER. The Negotiations concluded by issuing a joint news release, reflecting a commitment to share the progress reports on the efforts to implement ITER
Canonical formalism for coupled beam optics
International Nuclear Information System (INIS)
Kheifets, S.A.
1989-09-01
Beam optics of a lattice with an inter-plane coupling is treated using canonical Hamiltonian formalism. The method developed is equally applicable both to a circular (periodic) machine and to an open transport line. A solution of the equation of a particle motion (and correspondingly transfer matrix between two arbitrary points of the lattice) are described in terms of two amplitude functions (and their derivatives and corresponding phases of oscillations) and four coupling functions, defined by a solution of the system of the first-order nonlinear differential equations derived in the paper. Thus total number of independent parameters is equal to ten. 8 refs
Towards a formal logic of design rationalization
DEFF Research Database (Denmark)
Galle, Per
1997-01-01
Certain extensions to standard predicate logic are proposed and used as a framework for critical logical study of patterns of inference in design reasoning. It is shown that within this framework a modal logic of design rationalization (suggested by an empirical study reported earlier) can...... be formally defined in terms of quantification over a universe of discourse of ‘relevant points of view’. Five basic principles of the extended predicate logic are listed, on the basis of which the validity of ten modal patterns of inference encountered in design rationalization is tested. The basic idea...
Thermo field theory versus imaginary time formalism
International Nuclear Information System (INIS)
Fujimoto, Y.; Nishino, H.; Grigjanis, R.
1983-11-01
We calculate a two-loop diagram at finite temperature to compare Thermo Field Theory (=Th.F.Th.) with the conventional imaginary time formalism (=Im.T.F.). The summation over the Matsubara frequency in Im.T.F. is carried out at two-loop level, and the result is shown to coincide with that of Th.F.Th. We confirm that in Im.T.F. the temperature dependent divergences cancel out at least in the calculation of effective potential of phi 4 theory, as in Th.F.Th. (author)
Representations of spacetime: Formalism and ontological commitment
Bain, Jonathan Stanley
This dissertation consists of two parts. The first is on the relation between formalism and ontological commitment in the context of theories of spacetime, and the second is on scientific realism. The first part begins with a look at how the substantivalist/relationist debate over the ontological status of spacetime has been influenced by a particular mathematical formalism, that of tensor analysis on differential manifolds (TADM). This formalism has motivated the substantivalist position known as manifold substantivalism. Chapter 1 focuses on the hole argument which maintains that manifold substantivalism is incompatible with determinism. I claim that the realist motivations underlying manifold substantivalism can be upheld, and the hole argument avoided, by adopting structural realism with respect to spacetime. In this context, this is the claim that it is the structure that spacetime points enter into that warrants belief and not the points themselves. In Chapter 2, an elimination principle is defined by means of which a distinction can be made between surplus structure and essential structure with respect to formulations of a theory in two distinct mathematical formulations and some prior ontological commitments. This principle is then used to demonstrate that manifold points may be considered surplus structure in the formulation of field theories. This suggests that, if we are disposed to read field theories literally, then, at most, it should be the essential structure common to all alternative formulations of such theories that should be taken literally. I also investigate how the adoption of alternative formalisms informs other issues in the philosophy of spacetime. Chapter 3 offers a realist position which takes a semantic moral from the preceding investigation and an epistemic moral from work done on reliability. The semantic moral advises us to read only the essential structure of our theories literally. The epistemic moral shows us that such structure
Effective operator formalism for open quantum systems
DEFF Research Database (Denmark)
Reiter, Florentin; Sørensen, Anders Søndberg
2012-01-01
We present an effective operator formalism for open quantum systems. Employing perturbation theory and adiabatic elimination of excited states for a weakly driven system, we derive an effective master equation which reduces the evolution to the ground-state dynamics. The effective evolution...... involves a single effective Hamiltonian and one effective Lindblad operator for each naturally occurring decay process. Simple expressions are derived for the effective operators which can be directly applied to reach effective equations of motion for the ground states. We compare our method...
Does Formal Employment Reduce Informal Caregiving?
He, Daifeng; McHenry, Peter
2016-07-01
Using the Survey of Income and Program Participation, we examine the impact of formal employment on informal caregiving. We instrument for individual work hours with state unemployment rates. We find that, among women of prime caregiving ages (40-64 years), working 10% more hours per week reduces the probability of providing informal care by about 2 percentage points. The effects are stronger for more time-intensive caregiving and if care recipients are household members. Our results imply that work-promoting policies have the unintended consequence of reducing informal caregiving in an aging society. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.
Closing the gap between formalism and application
DEFF Research Database (Denmark)
Christensen, Ole Ravn
2008-01-01
A common problem in learning mathematics concerns the gap between, on the one hand, doing the formalisms and calculations of abstract mathematics and, on the other hand, applying these in a specific contextualized setting for example the engineering world. The skills acquired through problem......-based learning (PBL), in the special model used at Aalborg University, Denmark, may give us some idea of how to bridge this gap. Through an investigation of a series of examples of student projects concerning the application of mathematical subjects-such as matrices, differential equations, cluster analysis...
Constraint satisfaction problems CSP formalisms and techniques
Ghedira, Khaled
2013-01-01
A Constraint Satisfaction Problem (CSP) consists of a set of variables, a domain of values for each variable and a set of constraints. The objective is to assign a value for each variable such that all constraints are satisfied. CSPs continue to receive increased attention because of both their high complexity and their omnipresence in academic, industrial and even real-life problems. This is why they are the subject of intense research in both artificial intelligence and operations research. This book introduces the classic CSP and details several extensions/improvements of both formalisms a
Gaussian-approximation formalism for evaluating decay of NMR spin echoes
International Nuclear Information System (INIS)
Recchia, C.H.; Gorny, K.; Pennington, C.H.
1996-01-01
We present a formalism for evaluating the amplitude of the NMR spin echo and stimulated echo as a function of pulse spacings, for situations in which the nuclear spins experience an effective longitudinal magnetic field h z (t) resulting from an arbitrary number of independent sources, each characterized by its own arbitrary time correlation function. The distribution of accumulated phase angles for the ensemble of nuclear spins at the time of the echo is approximated as a Gaussian. The development of the formalism is motivated by the need to understand the transverse relaxation of 89 Y in YBa 2 Cu 3 O 7 , in which the 89 Y experiences 63,65 Cu dipolar fields which fluctuate due to 63,65 Cu T 1 processes. The formalism is applied successfully to this example, and to the case of nuclei diffusing in a spatially varying magnetic field. Then we examine a situation in which the approximation fails emdash the classic problem of chemical exchange in dimethylformamide, where the methyl protons experience a chemical shift which fluctuates between two discrete values. In this case the Gaussian approximation yields a monotonic decay of the echo amplitude with increasing pulse spacing, while the exact solution yields distinct open-quote open-quote beats close-quote close-quote in the echo height, which we confirm experimentally. In light of this final example the limits of validity of the approximation are discussed. copyright 1996 The American Physical Society
Non-Formal Educational Empowerment of Nigeria Youths for ...
African Journals Online (AJOL)
Religion Dept
discussed the concept of non-formal education, entrepreneurship and development, non-formal ... introducing some developmental programmes such as poverty alleviation .... aesthetic, cultural and civic education for public enlightenment.
Formalization of Hostel Management System. | Obi | Journal of the ...
African Journals Online (AJOL)
HMS) can invariably contribute greatly to the success, profitability and customerbased approach of such an organization. The use of formal specification creates a formal approach for specifying the underlying functions and properties of the ...
Early Number Competencies of Children at the Start of Formal ...
African Journals Online (AJOL)
cce
occupy a central position in the Primary Mathematics Curriculum in Ghana. ... The results of the study suggest that pupils possess varied abilities .... formal classroom instruction, to the use of memorised number facts and formal addition and.
Formal methods in software development: A road less travelled
Directory of Open Access Journals (Sweden)
John A van der Poll
2010-08-01
Full Text Available An integration of traditional verification techniques and formal specifications in software engineering is presented. Advocates of such techniques claim that mathematical formalisms allow them to produce quality, verifiably correct, or at least highly dependable software and that the testing and maintenance phases are shortened. Critics on the other hand maintain that software formalisms are hard to master, tedious to use and not well suited for the fast turnaround times demanded by industry. In this paper some popular formalisms and the advantages of using these during the early phases of the software development life cycle are presented. Employing the Floyd-Hoare verification principles during the formal specification phase facilitates reasoning about the properties of a specification. Some observations that may help to alleviate the formal-methods controversy are established and a number of formal methods successes is presented. Possible conditions for an increased acceptance of formalisms in oftware development are discussed.
String operator formalism and functional intergal in the holomorphic representation
International Nuclear Information System (INIS)
Losev, A.S.; Morozov, A.Yu.; Rislyj, A.A.; Shatashvili, S.L.
1989-01-01
Connection between the continual integral over open Riemann surfaces and the operator formalism on closed Riemann surfaces is discussed. States of the operator formalism are the holomorphic representation of the continual integral
Functional Constructivism: In Search of Formal Descriptors.
Trofimova, Irina
2017-10-01
The Functional Constructivism (FC) paradigm is an alternative to behaviorism and considers behavior as being generated every time anew, based on an individual's capacities, environmental resources and demands. Walter Freeman's work provided us with evidence supporting the FC principles. In this paper we make parallels between gradual construction processes leading to the formation of individual behavior and habits, and evolutionary processes leading to the establishment of biological systems. Referencing evolutionary theory, several formal descriptors of such processes are proposed. These FC descriptors refer to the most universal aspects for constructing consistent structures: expansion of degrees of freedom, integration processes based on internal and external compatibility between systems and maintenance processes, all given in four different classes of systems: (a) Zone of Proximate Development (poorly defined) systems; (b) peer systems with emerging reproduction of multiple siblings; (c) systems with internalized integration of behavioral elements ('cruise controls'); and (d) systems capable of handling low-probability, not yet present events. The recursive dynamics within this set of descriptors acting on (traditional) downward, upward and horizontal directions of evolution, is conceptualized as diagonal evolution, or di-evolution. Two examples applying these FC descriptors to taxonomy are given: classification of the functionality of neuro-transmitters and temperament traits; classification of mental disorders. The paper is an early step towards finding a formal language describing universal tendencies in highly diverse, complex and multi-level transient systems known in ecology and biology as 'contingency cycles.'
Formal specification level concepts, methods, and algorithms
Soeken, Mathias
2015-01-01
This book introduces a new level of abstraction that closes the gap between the textual specification of embedded systems and the executable model at the Electronic System Level (ESL). Readers will be enabled to operate at this new, Formal Specification Level (FSL), using models which not only allow significant verification tasks in this early stage of the design flow, but also can be extracted semi-automatically from the textual specification in an interactive manner. The authors explain how to use these verification tasks to check conceptual properties, e.g. whether requirements are in conflict, as well as dynamic behavior, in terms of execution traces. • Serves as a single-source reference to a new level of abstraction for embedded systems, known as the Formal Specification Level (FSL); • Provides a variety of use cases which can be adapted to readers’ specific design flows; • Includes a comprehensive illustration of Natural Language Processing (NLP) techniques, along with examples of how to i...
The MODUS Approach to Formal Verification
Directory of Open Access Journals (Sweden)
Brewka Lukasz
2014-03-01
Full Text Available Background: Software reliability is of great importance for the development of embedded systems that are often used in applications that have requirements for safety. Since the life cycle of embedded products is becoming shorter, productivity and quality simultaneously required and closely in the process of providing competitive products Objectives: In relation to this, MODUS (Method and supporting toolset advancing embedded systems quality project aims to provide small and medium-sized businesses ways to improve their position in the embedded market through a pragmatic and viable solution Methods/Approach: This paper will describe the MODUS project with focus on the technical methodologies that can assist formal verification and formal model checking. Results: Based on automated analysis of the characteristics of the system and by controlling the choice of the existing opensource model verification engines, model verification producing inputs to be fed into these engines. Conclusions: The MODUS approach is aligned with present market needs; the familiarity with tools, the ease of use and compatibility/interoperability remain among the most important criteria when selecting the development environment for a project
FORMAL METHOD TO IMPLEMENT FUZZY REQUIREMENTS
Directory of Open Access Journals (Sweden)
MARLENE GONCALVES
2012-01-01
Full Text Available RESUMEN: Muchos requerimientos de usuario pueden involucrar criterios de preferencia expresados en el lenguaje natural por medio de términos difusos; éstos son llamados requerimientos difusos. Por otro lado, los lenguajes de consulta a bases de datos han sido extendidos incorporando la lógica difusa para manejar las preferencias de usuarios. Pocas de las metodologías conocidas para el desarrollo de aplicaciones sobre base de datos consideran las consultas difusas. En este trabajo, se propone un método para aplicaciones a bases de datos cuyo objetivo es desarrollar sistemas de software con soporte de consultas difusas. Lo novedoso de éste es la extensión al cálculo de tuplas para la especificación formal de consultas difusas. Además, el método incluye reglas de traducción de una especificación formal a una consulta en SQLf (structured query language + fuzzy logic, un lenguaje de consultas difusas sobre bases de datos precisas. Se ilustra su utilidad con la aplicación a un caso de estudio real.
Versatile Formal Methods Applied to Quantum Information.
Energy Technology Data Exchange (ETDEWEB)
Witzel, Wayne [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Rudinger, Kenneth Michael [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Sarovar, Mohan [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
2015-11-01
Using a novel formal methods approach, we have generated computer-veri ed proofs of major theorems pertinent to the quantum phase estimation algorithm. This was accomplished using our Prove-It software package in Python. While many formal methods tools are available, their practical utility is limited. Translating a problem of interest into these systems and working through the steps of a proof is an art form that requires much expertise. One must surrender to the preferences and restrictions of the tool regarding how mathematical notions are expressed and what deductions are allowed. Automation is a major driver that forces restrictions. Our focus, on the other hand, is to produce a tool that allows users the ability to con rm proofs that are essentially known already. This goal is valuable in itself. We demonstrate the viability of our approach that allows the user great exibility in expressing state- ments and composing derivations. There were no major obstacles in following a textbook proof of the quantum phase estimation algorithm. There were tedious details of algebraic manipulations that we needed to implement (and a few that we did not have time to enter into our system) and some basic components that we needed to rethink, but there were no serious roadblocks. In the process, we made a number of convenient additions to our Prove-It package that will make certain algebraic manipulations easier to perform in the future. In fact, our intent is for our system to build upon itself in this manner.
Group adaptation, formal darwinism and contextual analysis.
Okasha, S; Paternotte, C
2012-06-01
We consider the question: under what circumstances can the concept of adaptation be applied to groups, rather than individuals? Gardner and Grafen (2009, J. Evol. Biol.22: 659-671) develop a novel approach to this question, building on Grafen's 'formal Darwinism' project, which defines adaptation in terms of links between evolutionary dynamics and optimization. They conclude that only clonal groups, and to a lesser extent groups in which reproductive competition is repressed, can be considered as adaptive units. We re-examine the conditions under which the selection-optimization links hold at the group level. We focus on an important distinction between two ways of understanding the links, which have different implications regarding group adaptationism. We show how the formal Darwinism approach can be reconciled with G.C. Williams' famous analysis of group adaptation, and we consider the relationships between group adaptation, the Price equation approach to multi-level selection, and the alternative approach based on contextual analysis. © 2012 The Authors. Journal of Evolutionary Biology © 2012 European Society For Evolutionary Biology.
Land grabbing and formalization in Africa : a critical inquiry
Stein, H.; Cunningham, S.
2015-01-01
Two developments in Africa have generated an extensive literature. The first focuses on investment and land grabbing and the second on the formalization of rural property rights. Less has been written on the impact of formalization on land grabbing and of land grabbing on formalization. Recently,
Sound Computational Interpretation of Formal Encryption with Composed Keys
Laud, P.; Corin, R.J.; In Lim, J.; Hoon Lee, D.
2003-01-01
The formal and computational views of cryptography have been related by the seminal work of Abadi and Rogaway. In their work, a formal treatment of encryption that uses atomic keys is justified in the computational world. However, many proposed formal approaches allow the use of composed keys, where
"Passing It On": Beyond Formal or Informal Pedagogies
Cain, Tim
2013-01-01
Informal pedagogies are a subject of debate in music education, and there is some evidence of teachers abandoning formal pedagogies in favour of informal ones. This article presents a case of one teacher's formal pedagogy and theorises it by comparing it with a case of informal pedagogy. The comparison reveals affordances of formal pedagogies…
An approach of requirements tracing in formal refinement
DEFF Research Database (Denmark)
Jastram, Michael; Hallerstede, Stefan; Leuschel, Michael
2010-01-01
Formal modeling of computing systems yields models that are intended to be correct with respect to the requirements that have been formalized. The complexity of typical computing systems can be addressed by formal refinement introducing all the necessary details piecemeal. We report on preliminar...... changes, making use of corresponding techniques already built into the Event-B method....
40 CFR 35.938-4 - Formal advertising.
2010-07-01
... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Formal advertising. 35.938-4 Section 35... advertising. Each contract shall be awarded after formal advertising, unless negotiation is permitted in accordance with § 35.936-18. Formal advertising shall be in accordance with the following: (a) Adequate...
Formalization of the Resolution Calculus for First-Order Logic
DEFF Research Database (Denmark)
Schlichtkrull, Anders
2018-01-01
between unsatisfiable sets of clauses and finite semantic trees is formalized in Herbrand’s theorem. I discuss the difficulties that I had formalizing proofs of the lifting lemma found in the literature, and I formalize a correct proof. The completeness proof is by induction on the size of a finite...
The base of the iceberg: informal learning and its impact on formal and non-formal learning
Rogers, Alan
2014-01-01
The author looks at learning (formal, non-formal and informal) and examines the hidden world of informal (unconscious, unplanned) learning. He points out the importance of informal learning for creating tacit attitudes and values, knowledge and skills which influence (conscious, planned) learning - formal and non-formal. Moreover, he explores the implications of informal learning for educational planners and teachers in the context of lifelong learning. While mainly aimed at adult educators, ...
The formal and the formalized: the cases of syllogistic and supposition theory
Dutilh Novaes, Catarina
2015-01-01
As a discipline, logic is arguably constituted of two main sub-projects: formal theories of argument validity on the basis of a small number of patterns, and theories of how to reduce the multiplicity of arguments in non-logical, informal contexts to the small number of patterns whose validity is
Developing Non-Formal Education Competences as a Complement of Formal Education for STEM Lecturers
Terrazas-Marín, Roy Alonso
2018-01-01
This paper focuses on a current practice piece on professional development for university lecturers, transformative learning, dialogism and STEM (Science, Technology, Engineering and Mathematics) education. Its main goals are to identify the key characteristics that allow STEM educators to experiment with the usage of non-formal education…
Sumida Huaman, Elizabeth; Valdiviezo, Laura Alicia
2014-01-01
In this article, we propose to approach Indigenous education beyond the formal/non-formal dichotomy. We argue that there is a critical need to conscientiously include Indigenous knowledge in education processes from the school to the community; particularly, when formal systems exclude Indigenous cultures and languages. Based on ethnographic…
Information Superiority via Formal Concept Analysis
Koester, Bjoern; Schmidt, Stefan E.
This chapter will show how to get more mileage out of information. To achieve that, we first start with an introduction to the fundamentals of Formal Concept Analysis (FCA). FCA is a highly versatile field of applied lattice theory, which allows hidden relationships to be uncovered in relational data. Moreover, FCA provides a distinguished supporting framework to subsequently find and fill information gaps in a systematic and rigorous way. In addition, we would like to build bridges via a universal approach to other communities which can be related to FCA in order for other research areas to benefit from a theory that has been elaborated for more than twenty years. Last but not least, the essential benefits of FCA will be presented algorithmically as well as theoretically by investigating a real data set from the MIPT Terrorism Knowledge Base and also by demonstrating an application in the field of Web Information Retrieval and Web Intelligence.
Toward a Grid Work flow Formal Composition
International Nuclear Information System (INIS)
Hlaoui, Y. B.; BenAyed, L. J.
2007-01-01
This paper exposes a new approach for the composition of grid work flow models. This approach proposes an abstract syntax for the UML Activity Diagrams (UML-AD) and a formal foundation for grid work flow composition in form of a work flow algebra based on UML-AD. This composition fulfils the need for collaborative model development particularly the specification and the reduction of the complexity of grid work flow model verification. This complexity has arisen with the increase in scale of grid work flow applications such as science and e-business applications since large amounts of computational resources are required and multiple parties could be involved in the development process and in the use of grid work flows. Furthermore, the proposed algebra allows the definition of work flow views which are useful to limit the access to predefined users in order to ensure the security of grid work flow applications. (Author)
Formal representation of complex SNOMED CT expressions
Directory of Open Access Journals (Sweden)
Markó Kornél
2008-10-01
Full Text Available Abstract Background Definitory expressions about clinical procedures, findings and diseases constitute a major benefit of a formally founded clinical reference terminology which is ontologically sound and suited for formal reasoning. SNOMED CT claims to support formal reasoning by description-logic based concept definitions. Methods On the basis of formal ontology criteria we analyze complex SNOMED CT concepts, such as "Concussion of Brain with(out Loss of Consciousness", using alternatively full first order logics and the description logic ℰℒ MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaWenfgDOvwBHrxAJfwnHbqeg0uy0HwzTfgDPnwy1aaceaGae8hmHuKae8NeHWeaaa@37B1@. Results Typical complex SNOMED CT concepts, including negations or not, can be expressed in full first-order logics. Negations cannot be properly expressed in the description logic ℰℒ MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGaciGaaiaabeqaaeqabiWaaaGcbaWenfgDOvwBHrxAJfwnHbqeg0uy0HwzTfgDPnwy1aaceaGae8hmHuKae8NeHWeaaa@37B1@ underlying SNOMED CT. All concepts concepts the meaning of which implies a temporal scope may be subject to diverging interpretations, which are often unclear in SNOMED CT as their contextual determinants are not made explicit. Conclusion The description of complex medical occurrents is ambiguous, as the same situations can be described as (i a complex occurrent C that has A and B as temporal parts, (ii a simple occurrent A' defined as a kind of A followed by some B, or (iii a simple occurrent B' defined as a kind of B preceded by some A. As negative statements in SNOMED CT cannot be exactly represented without
A Visual Formalism for Interacting Systems
Directory of Open Access Journals (Sweden)
Paul C. Jorgensen
2015-04-01
Full Text Available Interacting systems are increasingly common. Many examples pervade our everyday lives: automobiles, aircraft, defense systems, telephone switching systems, financial systems, national governments, and so on. Closer to computer science, embedded systems and Systems of Systems are further examples of interacting systems. Common to all of these is that some "whole" is made up of constituent parts, and these parts interact with each other. By design, these interactions are intentional, but it is the unintended interactions that are problematic. The Systems of Systems literature uses the terms "constituent systems" and "constituents" to refer to systems that interact with each other. That practice is followed here. This paper presents a visual formalism, Swim Lane Event-Driven Petri Nets, that is proposed as a basis for Model-Based Testing (MBT of interacting systems. In the absence of available tools, this model can only support the offline form of Model-Based Testing.
Formalized search strategies for human risk contributions
International Nuclear Information System (INIS)
Rasmussen, J.; Pedersen, O.M.
1982-07-01
For risk management, the results of a probabilistic risk analysis (PRA) as well as the underlying assumptions can be used as references in a closed-loop risk control; and the analyses of operational experiences as a means of feedback. In this context, the need for explicit definition and documentation of the PRA coverage, including the search strategies applied, is discussed and aids are proposed such as plant description in terms of a formal abstraction hierarchy and use of cause-consequence-charts for the documentation of not only the results of PRA but also of its coverage. Typical human risk contributions are described on the basis of general plant design features relevant for risk and accident analysis. With this background, search strategies for human risk contributions are treated: Under the designation ''work analysis'', procedures for the analysis of familiar, well trained, planned tasks are proposed. Strategies for identifying human risk contributions outside this category are outlined. (author)
Towards Safe Navigation by Formalizing Navigation Rules
Directory of Open Access Journals (Sweden)
Arne Kreutzmann
2013-06-01
Full Text Available One crucial aspect of safe navigation is to obey all navigation regulations applicable, in particular the collision regulations issued by the International Maritime Organization (IMO Colregs. Therefore, decision support systems for navigation need to respect Colregs and this feature should be verifiably correct. We tackle compliancy of navigation regulations from a perspective of software verification. One common approach is to use formal logic, but it requires to bridge a wide gap between navigation concepts and simple logic. We introduce a novel domain specification language based on a spatio-temporal logic that allows us to overcome this gap. We are able to capture complex navigation concepts in an easily comprehensible representation that can direcly be utilized by various bridge systems and that allows for software verification.
University and non-formal education
Directory of Open Access Journals (Sweden)
Popescu Liliana Georgeta
2017-01-01
Full Text Available Young students place great importance on their personal, professional and educational development alike but in the same time are actively involved in leisure activities. Through non-formal and informal activities the university can help students to develop new skills, can change or increase certain preferences regarding cultural consumption, sports and recreational activities. This paper presents the results of a study based on students attending universities across three cities. It aims to demonstrate that during the years spent at university, students are significantly less influenced by their parents in terms of behaviour and cultural preferences; instead these aspects as well as recreational activities are undertaken by universities and their group of friends and colleagues. For a meaningful analysis and correct interpretation of data, specific tools of quality management were used.
Enriching project organizations with formal change agents
DEFF Research Database (Denmark)
Eskerod, Pernille; Justesen, Just Bendix; Sjøgaard, Gisela
2017-01-01
Purpose: Project success requires effective and efficient cooperation between the project organization and the permanent organization in which the project takes place. The purpose of this paper is to discuss potentials and pitfalls from enriching project organizations by appointing peers as formal...... and middle and top management support are major determinants of success within change projects. To select change agents that the employees respect and can identify with, combined with top management prioritization, is important in order for the project organization to benefit from the additional role...... change agents. Design/methodology/approach: The paper is based on a literature review and a multiple-case study in which six organizations participated in an action-oriented research project. The aim for the organizations was to obtain a better health status among the employees by accomplishing...
Quantum Hamiltonian reduction in superspace formalism
International Nuclear Information System (INIS)
Madsen, J.O.; Ragoucy, E.
1994-02-01
Recently the quantum Hamiltonian reduction was done in the case of general sl(2) embeddings into Lie algebras and superalgebras. The results are extended to the quantum Hamiltonian reduction of N=1 affine Lie superalgebras in the superspace formalism. It is shown that if we choose a gauge for the supersymmetry, and consider only certain equivalence classes of fields, then our quantum Hamiltonian reduction reduces to quantum Hamiltonian reduction of non-supersymmetric Lie superalgebras. The super energy-momentum tensor is constructed explicitly as well as all generators of spin 1 (and 1/2); thus all generators in the superconformal, quasi-superconformal and Z 2 *Z 2 superconformal algebras are constructed. (authors). 21 refs
Biological formal counterparts of logical machines
Energy Technology Data Exchange (ETDEWEB)
Moreno-diaz, R; Hernandez Guarch, F
1983-01-01
The significance of the McCulloch-Pitts formal neural net theory (1943) is still nowadays frequently misunderstood, and their basic units are wrongly considered as factual models for neurons. As a consequence, the whole original theory and its later addenda are unreasonably criticized for their simplicity. But, as it was proved then and since, the theory is after the modular neurophysiological counterpart of logical machines, so that it actually provides biologically plausible models for automata, turing machines, etc., and not vice versa. In its true context, no theory has surpassed its proposals. In McCulloch and Pitts memoriam and for the sake of future theoretical research, the authors stress this important historical point, including also some recent results on the neurophysiological counterparts of modular arbitrary probabilistic automata. 16 references.
The formalisms of quantum mechanics an introduction
David, Francois
2015-01-01
These lecture notes present a concise and introductory, yet as far as possible coherent, view of the main formalizations of quantum mechanics and of quantum field theories, their interrelations and their theoretical foundations. The “standard” formulation of quantum mechanics (involving the Hilbert space of pure states, self-adjoint operators as physical observables, and the probabilistic interpretation given by the Born rule) on one hand, and the path integral and functional integral representations of probabilities amplitudes on the other, are the standard tools used in most applications of quantum theory in physics and chemistry. Yet, other mathematical representations of quantum mechanics sometimes allow better comprehension and justification of quantum theory. This text focuses on two of such representations: the algebraic formulation of quantum mechanics and the “quantum logic” approach. Last but not least, some emphasis will also be put on understanding the relation between quantum physics and ...
Building ontologies with basic formal ontology
Arp, Robert; Spear, Andrew D.
2015-01-01
In the era of "big data," science is increasingly information driven, and the potential for computers to store, manage, and integrate massive amounts of data has given rise to such new disciplinary fields as biomedical informatics. Applied ontology offers a strategy for the organization of scientific information in computer-tractable form, drawing on concepts not only from computer and information science but also from linguistics, logic, and philosophy. This book provides an introduction to the field of applied ontology that is of particular relevance to biomedicine, covering theoretical components of ontologies, best practices for ontology design, and examples of biomedical ontologies in use. After defining an ontology as a representation of the types of entities in a given domain, the book distinguishes between different kinds of ontologies and taxonomies, and shows how applied ontology draws on more traditional ideas from metaphysics. It presents the core features of the Basic Formal Ontology (BFO), now u...
Formalization and analysis of reasoning by assumption.
Bosse, Tibor; Jonker, Catholijn M; Treur, Jan
2006-01-02
This article introduces a novel approach for the analysis of the dynamics of reasoning processes and explores its applicability for the reasoning pattern called reasoning by assumption. More specifically, for a case study in the domain of a Master Mind game, it is shown how empirical human reasoning traces can be formalized and automatically analyzed against dynamic properties they fulfill. To this end, for the pattern of reasoning by assumption a variety of dynamic properties have been specified, some of which are considered characteristic for the reasoning pattern, whereas some other properties can be used to discriminate among different approaches to the reasoning. These properties have been automatically checked for the traces acquired in experiments undertaken. The approach turned out to be beneficial from two perspectives. First, checking characteristic properties contributes to the empirical validation of a theory on reasoning by assumption. Second, checking discriminating properties allows the analyst to identify different classes of human reasoners. 2006 Lawrence Erlbaum Associates, Inc.
Quadratic gravity in first order formalism
Energy Technology Data Exchange (ETDEWEB)
Alvarez, Enrique; Anero, Jesus; Gonzalez-Martin, Sergio, E-mail: enrique.alvarez@uam.es, E-mail: jesusanero@gmail.com, E-mail: sergio.gonzalez.martin@uam.es [Departamento de Física Teórica and Instituto de Física Teórica (IFT-UAM/CSIC), Universidad Autónoma de Madrid, Cantoblanco, 28049, Madrid (Spain)
2017-10-01
We consider the most general action for gravity which is quadratic in curvature. In this case first order and second order formalisms are not equivalent. This framework is a good candidate for a unitary and renormalizable theory of the gravitational field; in particular, there are no propagators falling down faster than 1/ p {sup 2}. The drawback is of course that the parameter space of the theory is too big, so that in many cases will be far away from a theory of gravity alone. In order to analyze this issue, the interaction between external sources was examined in some detail. We find that this interaction is conveyed mainly by propagation of the three-index connection field. At any rate the theory as it stands is in the conformal invariant phase; only when Weyl invariance is broken through the coupling to matter can an Einstein-Hilbert term (and its corresponding Planck mass scale) be generated by quantum corrections.
Exact classical scaling formalism for nonreactive processes
International Nuclear Information System (INIS)
DePristo, A.E.
1981-01-01
A general nonreactive collision system is considered with internal molecular variables (p, r) and/or (I, theta) of arbitrary dimensions and relative translational variables (P, R) of three or less dimensions. We derive an exact classical scaling formalism which relates the collisional change in any function of molecular variables directly to the initial values of these variables. The collision dynamics is then described by an explicit function of the initial point in the internal molecular phase space, for a fixed point in the relative translational phase space. In other words, the systematic variation of the internal molecular properties (e.g., actions and average internal kinetic energies) is given as a function of the initial internal action-angle variables. A simple three term approximation to the exact formalism is derived, the natural variables of which are the internal action I and internal linear momenta p. For the final average internal kinetic energies T, the result is T-T/sup( 0 ) = α+βp/sup( 0 )+γI/sup( 0 ), where the superscripted ''0'' indicates the initial value. The parameters α, β, and γ in this scaling theory are directly related to the moments of the change in average internal kinetic energy. Utilizing a very limited number of input moments generated from classical trajectory calculations, the scaling can be used to predict the entire distribution of final internal variables as a function of initial internal actions and linear momenta. Initial examples for atom--collinear harmonic oscillator collision systems are presented in detail, with the scaling predictions (e.g., moments and quasiclassical histogram transition probabilities) being generally very good to excellent quantitatively
Formal methods for industrial critical systems a survey of applications
Margaria-Steffen, Tiziana
2012-01-01
"Today, formal methods are widely recognized as an essential step in the design process of industrial safety-critical systems. In its more general definition, the term formal methods encompasses all notations having a precise mathematical semantics, together with their associated analysis methods, that allow description and reasoning about the behavior of a system in a formal manner.Growing out of more than a decade of award-winning collaborative work within the European Research Consortium for Informatics and Mathematics, Formal Methods for Industrial Critical Systems: A Survey of Applications presents a number of mainstream formal methods currently used for designing industrial critical systems, with a focus on model checking. The purpose of the book is threefold: to reduce the effort required to learn formal methods, which has been a major drawback for their industrial dissemination; to help designers to adopt the formal methods which are most appropriate for their systems; and to offer a panel of state-of...
Histone Lysine Methylation and Neurodevelopmental Disorders
Directory of Open Access Journals (Sweden)
Jeong-Hoon Kim
2017-06-01
Full Text Available Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available genomics techniques, such as exome sequencing, have identified an increasing number of histone lysine methylation-related genes as intellectual disability-associated genes, which highlights the importance of accurate control of histone methylation during neurogenesis. However, given the functional diversity and complexity of histone methylation within the cell, the study of the molecular basis of histone methylation-related neurodevelopmental disorders is currently still in its infancy. Here, we review the latest studies that revealed the pathological implications of alterations in histone methylation status in the context of various neurodevelopmental disorders and propose possible therapeutic application of epigenetic compounds regulating histone methylation status for the treatment of these diseases.
miRNAting control of DNA methylation
Indian Academy of Sciences (India)
miRNAting control of DNA methylation. ASHWANI ... function and biological process ... Enrichment analysis of the genes methylated by DRM2 for molecular function and biological ... 39(3), June 2014, 365–380, © Indian Academy of Sciences.
Formal Semantics: Origins, Issues, Early Impact
Directory of Open Access Journals (Sweden)
Barbara H. Partee
2010-12-01
Full Text Available Formal semantics and pragmatics as they have developed since the late 1960's have been shaped by fruitful interdisciplinary collaboration among linguists, philosophers, and logicians, among others, and in turn have had noticeable effects on developments in syntax, philosophy of language, computational linguistics, and cognitive science.In this paper I describe the environment in which formal semantics was born and took root, highlighting the differences in ways of thinking about natural language semantics in linguistics and in philosophy and logic. With Montague as a central but not solo player in the story, I reflect on crucial developments in the 1960's and 70's in linguistics and philosophy, and the growth of formal semantics and formal pragmatics from there. I discuss innovations, key players, and leading ideas that shaped the development of formal semantics and its relation to syntax, to pragmatics, and to the philosophy of language in its early years, and some central aspects of its early impact on those fields.ReferencesAbbott, B. 1999. ‘The formal approach to meaning: Formal semantics and its recent developments’. Journal of Foreign Languages (Shanghai119, no. 1: 2–20. https://www.msu.edu/~abbottb/formal.htm.Ajdukiewicz, K. 1960. Je¸zyk i Poznanie (Language and Knowledge. Warsaw.Bach, E. 1968. ‘Nouns and Noun Phrases’. In E. Bach & R.T. Harms (eds. ‘Universals in Linguistic Theory’, 90–122. NY: Holt, Rinehart & Winston.Bach, E. 1989. Informal Lectures on Formal Semantics. New York: State University of New York Press.Bar-Hillel, Y. 1954a. ‘Logical syntax and semantics’. Language 30: 230–237.http://dx.doi.org/10.2307/410265Bar-Hillel, Y. 1954b. ‘Indexical Expressions’. Mind 63: 359–379.http://dx.doi.org/10.1093/mind/LXIII.251.359Bar-Hillel, Y. 1963. ‘Remarks on Carnap’s Logical Syntax of Language’. In P. A. Schilpp (ed. ‘The Philosophy of Rudolf Carnap’, 519–543. LaSalle, Illinois / London: Open
Bacterial production of methyl ketones
Energy Technology Data Exchange (ETDEWEB)
Beller, Harry R.; Goh, Ee-Been
2017-01-31
The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces .beta.-ketoacyl-CoAs through a re-engineered .beta.-oxidation pathway and overexpresses FadM.
Electronic transport in methylated fragments of DNA
International Nuclear Information System (INIS)
Almeida, M. L. de; Oliveira, J. I. N.; Lima Neto, J. X.; Gomes, C. E. M.; Fulco, U. L.; Albuquerque, E. L.; Freire, V. N.; Caetano, E. W. S.; Moura, F. A. B. F. de; Lyra, M. L.
2015-01-01
We investigate the electronic transport properties of methylated deoxyribonucleic-acid (DNA) strands, a biological system in which methyl groups are added to DNA (a major epigenetic modification in gene expression), sandwiched between two metallic platinum electrodes. Our theoretical simulations apply an effective Hamiltonian based on a tight-binding model to obtain current-voltage curves related to the non-methylated/methylated DNA strands. The results suggest potential applications in the development of novel biosensors for molecular diagnostics
Electronic transport in methylated fragments of DNA
Energy Technology Data Exchange (ETDEWEB)
Almeida, M. L. de; Oliveira, J. I. N.; Lima Neto, J. X.; Gomes, C. E. M.; Fulco, U. L., E-mail: umbertofulco@gmail.com; Albuquerque, E. L. [Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, 59072-970 Natal-RN (Brazil); Freire, V. N. [Departamento de Física, Universidade Federal do Ceará, 60455-760 Fortaleza, CE (Brazil); Caetano, E. W. S. [Instituto Federal de Educação, Ciência e Tecnologia do Ceará, 60040-531 Fortaleza, CE (Brazil); Moura, F. A. B. F. de; Lyra, M. L. [Instituto de Física, Universidade Federal de Alagoas, 57072-900 Maceió-AL (Brazil)
2015-11-16
We investigate the electronic transport properties of methylated deoxyribonucleic-acid (DNA) strands, a biological system in which methyl groups are added to DNA (a major epigenetic modification in gene expression), sandwiched between two metallic platinum electrodes. Our theoretical simulations apply an effective Hamiltonian based on a tight-binding model to obtain current-voltage curves related to the non-methylated/methylated DNA strands. The results suggest potential applications in the development of novel biosensors for molecular diagnostics.
The Integration of Formal and Non-formal Education: The Dutch “brede school”
Directory of Open Access Journals (Sweden)
du Bois-Reymond, Manuela
2009-12-01
Full Text Available The Dutch “brede school” (BS development originates in the 1990s and has spread unevenly since: quicker in the primary than secondary educational sector. In 2007, there were about 1000 primary and 350 secondary BS schools and it is the intention of the government as well as the individual municipalities to extend that number and make the BS the dominant school form of the near future. In the primary sector, a BS cooperates with crèche and preschool facilities, besides possible other neighborhood partners. The main targets are, first, to enhance educational opportunities, particularly for children with little (western- cultural capital, and secondly to increase women’s labor market participation by providing extra familial care for babies and small children. All primary schools are now obliged to provide such care. In the secondary sector, a BS is less neighborhood-orientated than a primary BS because those schools are bigger and more often located in different buildings. As in the primary sector, there are broad and more narrow BS, the first profile cooperating with many non-formal and other partners and facilities and the second with few. On the whole, there is a wide variety of BS schools, with different profiles and objectives, dependent on the needs and wishes of the initiators and the neighborhood. A BS is always the result of initiatives of the respective school and its partners: parents, other neighborhood associations, municipality etc. BS schools are not enforced by the government although the general trend will be that existing school organizations transform into BS. The integration of formal and non-formal education and learning is more advanced in primary than secondary schools. In secondary education, vocational as well as general, there is a clear dominance of formal education; the non-formal curriculum serves mainly two lines and objectives: first, provide attractive leisure activities and second provide compensatory
Methylation sensitive amplified polymorphism (MSAP) reveals that ...
African Journals Online (AJOL)
ajl yemi
2011-12-19
Dec 19, 2011 ... Key words: Salt stress, alkali stress, Gossypium hirsutum L., DNA methylation, methylation sensitive amplified polymorphism (MSAP). INTRODUCTION. DNA methylation is one of the key epigenetic mecha- nisms among eukaryotes that can modulate gene expression without the changes of DNA sequence.
miRNAting control of DNA methylation
Indian Academy of Sciences (India)
DNA methylation is a type of epigenetic modification where a methyl group is added to the cytosine or adenine residue of a given DNA sequence. It has been observed that DNA methylation is achieved by some collaborative agglomeration of certain proteins and non-coding RNAs. The assembly of IDN2 and its ...
Intuitions and Competence in Formal Semantics
Directory of Open Access Journals (Sweden)
Martin Stokhof
2010-12-01
Full Text Available In formal semantics intuition plays a key role, in two ways. Intuitions about semantic properties of expressions are the primary data, and intuitions of the semanticists are the main access to these data. The paper investigates how this dual role is related to the concept of competence and the role that this concept plays in semantics. And it inquires whether the self-reflexive role of intuitions has consequences for the methodology of semantics as an empirical discipline.ReferencesBaggio, Giosuè, van Lambalgen, Michiel & Hagoort, Peter. 2008. ‘Computing and recomputing discourse models: an ERP study of the semantics of temporal connectives’. Journal of Memory and Language 59, no. 1: 36–53.http://dx.doi.org/10.1016/j.jml.2008.02.005Chierchia, Gennaro & McConnell-Ginet, Sally. 2000. Meaning and Grammar. second ed. Cambridge, Mass.: MIT Press.Chomsky, Noam. 1965. Aspects of the Theory of Syntax. Cambridge, Mass.: MIT Press.Cresswell, Max J. 1978. ‘Semantic competence’. In F. Guenthner & M. Guenther-Reutter (eds. ‘Meaning and Translation’, 9–27. Duckworth, London. de Swart, Henriëtte. 1998. Introduction to Natural Language Semantics. Stanford: CSLI.Dowty, David, Wall, Robert & Peters, Stanley. 1981. Introduction to Montague Semantics. Dordrecht: Reidel.Heim, Irene & Kratzer, Angelika. 1998. Semantics in Generative Grammar. Oxford: Blackwell.Larson, Richard & Segal, Gabriel. 1995. Knowledge of Meaning. Cambridge, Mass.: MIT Press.Lewis, David K. 1975. ‘Languages and Language’. In Keith Gunderson (ed. ‘Language, Mind and Knowledge’, 3–35. Minneapolis: University of Minnesota Press.Montague, Richard. 1970. ‘Universal Grammar’. Theoria 36: 373–98.http://dx.doi.org/10.1111/j.1755-2567.1970.tb00434.xPartee, Barbara H. 1979. ‘Semantics – Mathematics or Psychology?’ In Rainer Bäuerle, Urs Egli & Arnim von Stechow (eds. ‘Semantics from Different Points of View’, 1–14. Berlin: Springer.Partee, Barbara H. 1980.
Connecting Formal and Informal Learning Experiences
O'Mahony, Timothy Kieran
The learning study reports on part of a larger project being lead by the author. In this dissertation I explore one goal of this project---to understand effects on student learning outcomes as a function of using different methods for connecting out-of-school experiential learning with formal school-based instruction. There is a long history of assuming that "experience is the best teacher"(e.g. Aristotle, 360 BC; Dewey, 1934; Kolb, 1997; Pliny, AD 77). As a practical geographer I endorsed that assumption throughout my teaching career, paying attention to local topography, physical features, and natural resources in the geographic hinterland. I was particularly interested in understanding the impact of the physical landscape on humankind, and reciprocally, noting humankind's widespread impressions on the natural world. Until I began this research project, I assumed that everyone else paid a similar attention to immediate surroundings. The work that I describe in this dissertation emerges out of a conviction that there are many degrees of truth to the idea that experience is a great teacher. Its effectiveness seems to depend on how one's "experience" is mediated, and how "learning from it" is defined. This motivated me to think about design principles for linking people's experiences to learning. I began to explore, experimentally, how I might enhance people's abilities to notice, represent, and discuss their experiences in order to better learn from them. This study investigated how different ways of connecting outdoor learning experiences to formal schooling impacts students' performance. I studied high-school students in outdoor settings as they engaged in evocative issues of learning pertaining to consequential everyday life encounters. Different kinds of "expert mediation" were introduced and tested as the students engaged in investigative activities around the science of dam removal and habitat restoration. I measured outcomes with the aid of pre- and
DEFF Research Database (Denmark)
Børgesen, Kenneth; Nielsen, Rikke Kristine; Henriksen, Thomas Duus
2016-01-01
Purpose This paper aims to address the necessity of allowing non-formal and informal processes to unfold when using business games for leadership development. While games and simulations have long been used in management training and leadership development, emphasis has been placed on the formal...... of the process is not assessed. Practical implications This paper suggests that the use of business games in leadership development should focus more on the processes and activities surrounding the game rather than narrowly focusing on the game. Originality/value This paper suggests a novel approach to using...... parts of the process and especially on the gaming experience. Design/methodology/approach This paper is based on a qualitative study of a French management game on change management, in which the game-based learning process is examined in light of adult learning. Findings This paper concludes that less...
Dechamps, Noémie; Flammang, Robert; Gerbaux, Pascal; Nam, Pham-Cam; Nguyen, Minh Tho
2006-03-01
The C6H5C+(OH)OCH2 radical cation, formally a distonic isomer of ionized methyl benzoate, has been prepared by dissociative ionization of neopentyl benzoate, as earlier suggested by Audier et al. [H.E. Audier, A. Milliet, G. Sozzi, S. Hammerum, Org. Mass. Spectrom. 25 (1990) 44]. Its distonic character has now been firmly established by its high reactivity towards neutral methyl isocyanide (ionized methylene transfer) producing N-methyl ketenimine ions. Other mass spectrometric experiments and ab initio quantum chemical calculations also concur with each other pointing toward the existence of a stable distonic radical cation.
Directory of Open Access Journals (Sweden)
Michael P Trimarchi
Full Text Available DNA methylation is a stable epigenetic mark that is frequently altered in tumors. DNA methylation features are attractive biomarkers for disease states given the stability of DNA methylation in living cells and in biologic specimens typically available for analysis. Widespread accumulation of methylation in regulatory elements in some cancers (specifically the CpG island methylator phenotype, CIMP can play an important role in tumorigenesis. High resolution assessment of CIMP for the entire genome, however, remains cost prohibitive and requires quantities of DNA not available for many tissue samples of interest. Genome-wide scans of methylation have been undertaken for large numbers of tumors, and higher resolution analyses for a limited number of cancer specimens. Methods for analyzing such large datasets and integrating findings from different studies continue to evolve. An approach for comparison of findings from a genome-wide assessment of the methylated component of tumor DNA and more widely applied methylation scans was developed.Methylomes for 76 primary endometrial cancer and 12 normal endometrial samples were generated using methylated fragment capture and second generation sequencing, MethylCap-seq. Publically available Infinium HumanMethylation 450 data from The Cancer Genome Atlas (TCGA were compared to MethylCap-seq data.Analysis of methylation in promoter CpG islands (CGIs identified a subset of tumors with a methylator phenotype. We used a two-stage approach to develop a 13-region methylation signature associated with a "hypermethylator state." High level methylation for the 13-region methylation signatures was associated with mismatch repair deficiency, high mutation rate, and low somatic copy number alteration in the TCGA test set. In addition, the signature devised showed good agreement with previously described methylation clusters devised by TCGA.We identified a methylation signature for a "hypermethylator phenotype" in
Warm inflation in the stochastic inflation formalism
International Nuclear Information System (INIS)
Silva, Leandro A. da; Ramos, Rudnei O.
2011-01-01
Full text: The basic assumption of stochastic inflation is the splitting, through the definition of a appropriate window function, of the quantum inflaton field in a long wavelength part (modes outside of the de Sitter horizon) and in a short wavelength (modes inside the de Sitter horizon) part. The inflationary mechanism then continuously shifts more and more modes of the bath field into the system stretching their physical wavelengths beyond the de Sitter horizon size, what generates an effective system-bath interaction. Therefore, the system field develops a stochastic dynamics driven by the bath field, that plays the role of noise source. The resulting equation of motion (EoM) is a Langevin-like equation. Applying this formalism to Warm Inflation scenario (where, alternatively to the cold inflation, we assume that the inflaton evolves in a thermal bath and through a dissipative process continuously generates radiation, thus avoiding the necessity of a reheating mechanism), we contrast the exact numerical solution of thermal power spectrum and two approximations currently used in the literature, and compare this to the quantum power spectrum at horizon crossing. Finally, we consider a more realistic model based on microscopic derivations to estimate the effects of non-Markovianity on the inflaton dynamics and on the thermal power spectrum. (author)
Boltzmann hierarchy for interacting neutrinos I: formalism
International Nuclear Information System (INIS)
Oldengott, Isabel M.; Rampf, Cornelius; Wong, Yvonne Y.Y.
2015-01-01
Starting from the collisional Boltzmann equation, we derive for the first time and from first principles the Boltzmann hierarchy for neutrinos including interactions with a scalar particle. Such interactions appear, for example, in majoron-like models of neutrino mass generation. We study two limits of the scalar mass: (i) An extremely massive scalar whose only role is to mediate an effective 4-fermion neutrino-neutrino interaction, and (ii) a massless scalar that can be produced in abundance and thus demands its own Boltzmann hierarchy. In contrast to, e.g., the first-order Boltzmann hierarchy for Thomson-scattering photons, our interacting neutrino/scalar Boltzmann hierarchies contain additional momentum-dependent collision terms arising from a non-negligible energy transfer in the neutrino-neutrino and neutrino-scalar interactions. This necessitates that we track each momentum mode of the phase space distributions individually, even if the particles were massless. Comparing our hierarchy with the commonly used (c eff 2 ,c vis 2 )-parameterisation, we find no formal correspondence between the two approaches, which raises the question of whether the latter parameterisation even has an interpretation in terms of particle scattering. Lastly, although we have invoked majoron-like models as a motivation for our study, our treatment is in fact generally applicable to all scenarios in which the neutrino and/or other ultrarelativistic fermions interact with scalar particles
Some formal problems in gauge theories
International Nuclear Information System (INIS)
Magpantay, J.A.
1980-01-01
The concerns of this thesis are the problems due to the extra degrees of freedom in gauge-invariant theories. Since gauge-invariant Lagrangians are singular, Dirac's consistency formalism and Fadeev's extension are first reviewed. A clarification on the origin of primary constraints is given, and some of the open problems in singular Lagrangian theory are discussed. The criteria in choosing a gauge, i.e., attainability, maintainability and Poincare invariance are summarized and applied to various linear gauges. The effects of incomplete removal of all gauge freedom on the criteria for gauge conditions are described. A simple example in point mechanics that contains some of the features of gauge field theories is given. Finally, we describe a method of constructing gauge-invariant variables in various gauge field theories. For the Abelian theory, the gauge-invariant, transverse potential and Dirac's gauge-invariant fermion field was derived. For the non-Abelian case we introduce a local set of basis vectors and gauge transformations are interpreted as rotations of the basis vectors introduced. The analysis leads to the reformulation of local SU(2) field theory in terms of path-dependent U(1) x U(1) x U(1). However, the analysis fails to include the matter fields as of now
Quantum mechanics formalism for biological evolution
International Nuclear Information System (INIS)
Bianconi, Ginestra; Rahmede, Christoph
2012-01-01
Highlights: ► Biological evolution is an off-equilibrium process described by path integrals over phylogenies. ► The phylogenies are sums of linear lineages for asexual populations. ► For sexual populations, each lineage is a tree and the path integral is given by a sum over these trees. ► Quantum statistics describe the stationary state of biological populations in simple cases. - Abstract: We study the evolution of sexual and asexual populations in fitness landscapes compatible with epistatic interactions. We find intriguing relations between the mathematics of biological evolution and quantum mechanics formalism. We give the general structure of the evolution of sexual and asexual populations which is in general an off-equilibrium process that can be expressed by path integrals over phylogenies. These phylogenies are the sum of linear lineages for asexual populations. For sexual populations, instead, each lineage is a tree of branching ratio two and the path integral describing the evolving population is given by a sum over these trees. Finally we show that the Bose–Einstein and the Fermi–Dirac distributions describe the stationary state of biological populations in simple cases.
Colloquium: Mechanical formalisms for tissue dynamics.
Tlili, Sham; Gay, Cyprien; Graner, François; Marcq, Philippe; Molino, François; Saramito, Pierre
2015-05-01
The understanding of morphogenesis in living organisms has been renewed by tremendous progress in experimental techniques that provide access to cell scale, quantitative information both on the shapes of cells within tissues and on the genes being expressed. This information suggests that our understanding of the respective contributions of gene expression and mechanics, and of their crucial entanglement, will soon leap forward. Biomechanics increasingly benefits from models, which assist the design and interpretation of experiments, point out the main ingredients and assumptions, and ultimately lead to predictions. The newly accessible local information thus calls for a reflection on how to select suitable classes of mechanical models. We review both mechanical ingredients suggested by the current knowledge of tissue behaviour, and modelling methods that can help generate a rheological diagram or a constitutive equation. We distinguish cell scale ("intra-cell") and tissue scale ("inter-cell") contributions. We recall the mathematical framework developed for continuum materials and explain how to transform a constitutive equation into a set of partial differential equations amenable to numerical resolution. We show that when plastic behaviour is relevant, the dissipation function formalism appears appropriate to generate constitutive equations; its variational nature facilitates numerical implementation, and we discuss adaptations needed in the case of large deformations. The present article gathers theoretical methods that can readily enhance the significance of the data to be extracted from recent or future high throughput biomechanical experiments.
Formal Methods Applications in Air Transportation
Farley, Todd
2009-01-01
The U.S. air transportation system is the most productive in the world, moving far more people and goods than any other. It is also the safest system in the world, thanks in part to its venerable air traffic control system. But as demand for air travel continues to grow, the air traffic control system s aging infrastructure and labor-intensive procedures are impinging on its ability to keep pace with demand. And that impinges on the growth of our economy. Air traffic control modernization has long held the promise of a more efficient air transportation system. Part of NASA s current mission is to develop advanced automation and operational concepts that will expand the capacity of our national airspace system while still maintaining its excellent record for safety. It is a challenging mission, as efforts to modernize have, for decades, been hamstrung by the inability to assure safety to the satisfaction of system operators, system regulators, and/or the traveling public. In this talk, we ll provide a brief history of air traffic control, focusing on the tension between efficiency and safety assurance, and the promise of formal methods going forward.
Application of Bondarenko formalism to fusion reactors
International Nuclear Information System (INIS)
Soran, P.D.; Dudziak, D.J.
1975-01-01
The Bondarenko formalism used to account for resonance self-shielding effects (temperature and composition) in a Reference Theta-Pinch Reactor is reviewed. A material of interest in the RTPR blanket is 93 Nb, which exhibits a large number of capture resonance in the energy region below 800 keV. Although Nb constitutes a small volume fraction of the blanket, its presence significantly affects the nucleonic properties of the RTPR blanket. The effects of self-shielding in 93 Nb on blanket parameters such as breeding ratio, total afterheat, radioactivity, magnet-coil heating and total energy depositions have been studied. Resonance self-shielding of 93 Nb, as compared to unshielded cross sections, will increase tritium breeding by approximately 7 percent in the RTPR blanket and will decrease blanket radioactivity, total recoverable energy, and magnet-coil heating. Temperature effects change these parameters by less than 2 percent. The method is not restricted to the RTPR, as a single set of Bondarenko f-factors is suitable for application to a variety of fusion reactor designs
Starobinsky cosmological model in Palatini formalism
Energy Technology Data Exchange (ETDEWEB)
Stachowski, Aleksander [Jagiellonian University, Astronomical Observatory, Krakow (Poland); Szydlowski, Marek [Jagiellonian University, Astronomical Observatory, Krakow (Poland); Jagiellonian University, Mark Kac Complex Systems Research Centre, Krakow (Poland); Borowiec, Andrzej [Wroclaw University, Institute for Theoretical Physics, Wroclaw (Poland)
2017-06-15
We classify singularities in FRW cosmologies, which dynamics can be reduced to the dynamical system of the Newtonian type. This classification is performed in terms of the geometry of a potential function if it has poles. At the sewn singularity, which is of a finite scale factor type, the singularity in the past meets the singularity in the future. We show that such singularities appear in the Starobinsky model in f(R) = R + γR{sup 2} in the Palatini formalism, when dynamics is determined by the corresponding piecewise-smooth dynamical system. As an effect we obtain a degenerate singularity. Analytical calculations are given for the cosmological model with matter and the cosmological constant. The dynamics of model is also studied using dynamical system methods. From the phase portraits we find generic evolutionary scenarios of the evolution of the universe. For this model, the best fit value of Ω{sub γ} = 3γH{sub 0}{sup 2} is equal 9.70 x 10{sup -11}. We consider a model in both Jordan and Einstein frames. We show that after transition to the Einstein frame we obtain both the form of the potential of the scalar field and the decaying Lambda term. (orig.)
MethylMix 2.0: an R package for identifying DNA methylation genes.
Cedoz, Pierre-Louis; Prunello, Marcos; Brennan, Kevin; Gevaert, Olivier
2018-04-14
DNA methylation is an important mechanism regulating gene transcription, and its role in carcinogenesis has been extensively studied. Hyper and hypomethylation of genes is a major mechanism of gene expression deregulation in a wide range of diseases. At the same time, high-throughput DNA methylation assays have been developed generating vast amounts of genome wide DNA methylation measurements. We developed MethylMix, an algorithm implemented in R to identify disease specific hyper and hypomethylated genes. Here we present a new version of MethylMix that automates the construction of DNA-methylation and gene expression datasets from The Cancer Genome Atlas (TCGA). More precisely, MethylMix 2.0 incorporates two major updates: the automated downloading of DNA methylation and gene expression datasets from TCGA and the automated preprocessing of such datasets: value imputation, batch correction and CpG sites clustering within each gene. The resulting datasets can subsequently be analyzed with MethylMix to identify transcriptionally predictive methylation states. We show that the Differential Methylation Values created by MethylMix can be used for cancer subtyping. olivier.gevaert@stanford.edu. https://bioconductor.org/packages/release/bioc/manuals/MethylMix/man/MethylMix.pdf. MethylMix 2.0 was implemented as an R package and is available in bioconductor.
multiPDEVS: A Parallel Multicomponent System Specification Formalism
Directory of Open Access Journals (Sweden)
Damien Foures
2018-01-01
Full Text Available Based on multiDEVS formalism, we introduce multiPDEVS, a parallel and nonmodular formalism for discrete event system specification. This formalism provides combined advantages of PDEVS and multiDEVS approaches, such as excellent simulation capabilities for simultaneously scheduled events and components able to influence each other using exclusively their state transitions. We next show the soundness of the formalism by giving a construction showing that any multiPDEVS model is equivalent to a PDEVS atomic model. We then present the simulation procedure associated, usually called abstract simulator. As a well-adapted formalism to express cellular automata, we finally propose to compare an implementation of multiPDEVS formalism with a more classical Cell-DEVS implementation through a fire spread application.
Formal verification of Simulink/Stateflow diagrams a deductive approach
Zhan, Naijun; Zhao, Hengjun
2017-01-01
This book presents a state-of-the-art technique for formal verification of continuous-time Simulink/Stateflow diagrams, featuring an expressive hybrid system modelling language, a powerful specification logic and deduction-based verification approach, and some impressive, realistic case studies. Readers will learn the HCSP/HHL-based deductive method and the use of corresponding tools for formal verification of Simulink/Stateflow diagrams. They will also gain some basic ideas about fundamental elements of formal methods such as formal syntax and semantics, and especially the common techniques applied in formal modelling and verification of hybrid systems. By investigating the successful case studies, readers will realize how to apply the pure theory and techniques to real applications, and hopefully will be inspired to start to use the proposed approach, or even develop their own formal methods in their future work.
Avocado and olive oil methyl esters
International Nuclear Information System (INIS)
Knothe, Gerhard
2013-01-01
Biodiesel, the mono-alkyl esters of vegetable oils, animal fats or other triacylglycerol-containing materials and an alternative to conventional petroleum-based diesel fuel, has been derived from a variety of feedstocks. Numerous feedstocks have been investigated as potential biodiesel sources, including commodity oils, however, the methyl esters of avocado and olive oil would likely be suitable as biodiesel fuel. In order to expand the database and comprehensive evaluation of the properties of vegetable oil esters, in this work the fuel-related properties of avocado and olive oil methyl esters, which exhibit similar fatty acid profiles including high oleic acid content, are determined. The cetane numbers of avocado oil methyl esters and olive oil methyl esters are relatively high, determined as 59.2 and 62.5, respectively, due to their elevated content of methyl oleate. Other properties are well within the ranges specified in biodiesel standards. The cloud points of both esters are slightly above 0 °C due to their content of saturated esters, especially methyl palmitate. Overall, avocado and olive oil yield methyl esters with fuel properties comparable to methyl esters from other commodity vegetable oils. The 1 H and 13 C NMR spectra of avocado and olive oil methyl esters are reported. -- Highlights: • Methyl esters of avocado and olive oil meet biodiesel fuel standards. • Provides comparison for methyl esters of other vegetable oils with high oleic content. • Discusses and compares present results with prior literature
Methylated genes as new cancer biomarkers.
LENUS (Irish Health Repository)
Duffy, M J
2012-02-01
Aberrant hypermethylation of promoter regions in specific genes is a key event in the formation and progression of cancer. In at least some situations, these aberrant alterations occur early in the formation of malignancy and appear to be tumour specific. Multiple reports have suggested that measurement of the methylation status of the promoter regions of specific genes can aid early detection of cancer, determine prognosis and predict therapy responses. Promising DNA methylation biomarkers include the use of methylated GSTP1 for aiding the early diagnosis of prostate cancer, methylated PITX2 for predicting outcome in lymph node-negative breast cancer patients and methylated MGMT in predicting benefit from alkylating agents in patients with glioblastomas. However, prior to clinical utilisation, these findings require validation in prospective clinical studies. Furthermore, assays for measuring gene methylation need to be standardised, simplified and evaluated in external quality assurance programmes. It is concluded that methylated genes have the potential to provide a new generation of cancer biomarkers.
Formality theory from Poisson structures to deformation quantization
Esposito, Chiara
2015-01-01
This book is a survey of the theory of formal deformation quantization of Poisson manifolds, in the formalism developed by Kontsevich. It is intended as an educational introduction for mathematical physicists who are dealing with the subject for the first time. The main topics covered are the theory of Poisson manifolds, star products and their classification, deformations of associative algebras and the formality theorem. Readers will also be familiarized with the relevant physical motivations underlying the purely mathematical construction.
What determines firms' decisions to formalize? Evidence from rural Indonesia
McCulloch, Neil; Schulze, Günther G.; Voss, Janina
2010-01-01
In this paper we analyze the decision of small and micro firms to formalize, i.e. to obtain business and other licenses in rural Indonesia. We use the rural investment climate survey (RICS) that consists of non-farm rural enterprises, most of them microenterprises, and analyze the effect of formalization on tax payments, corruption, access to credit and revenue, taking into account the endogeneity of the formalization decision to such benefits and costs. We show, contrary to most of the liter...
A formalism for the calculus of variations with spinors
Energy Technology Data Exchange (ETDEWEB)
Bäckdahl, Thomas, E-mail: thobac@chalmers.se [The School of Mathematics, University of Edinburgh, JCMB 6228, Peter Guthrie Tait Road, Edinburgh EH9 3FD, United Kingdom and Mathematical Sciences - Chalmers University of Technology and University of Gothenburg - SE-412 96 Gothenburg (Sweden); Valiente Kroon, Juan A., E-mail: j.a.valiente-kroon@qmul.ac.uk [School of Mathematical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS (United Kingdom)
2016-02-15
We develop a frame and dyad gauge-independent formalism for the calculus of variations of functionals involving spinorial objects. As a part of this formalism, we define a modified variation operator which absorbs frame and spin dyad gauge terms. This formalism is applicable to both the standard spacetime (i.e., SL(2, ℂ)) 2-spinors as well as to space (i.e., SU(2, ℂ)) 2-spinors. We compute expressions for the variations of the connection and the curvature spinors.
A formalism for the calculus of variations with spinors
International Nuclear Information System (INIS)
Bäckdahl, Thomas; Valiente Kroon, Juan A.
2016-01-01
We develop a frame and dyad gauge-independent formalism for the calculus of variations of functionals involving spinorial objects. As a part of this formalism, we define a modified variation operator which absorbs frame and spin dyad gauge terms. This formalism is applicable to both the standard spacetime (i.e., SL(2, ℂ)) 2-spinors as well as to space (i.e., SU(2, ℂ)) 2-spinors. We compute expressions for the variations of the connection and the curvature spinors
General many-body formalism for composite quantum particles.
Combescot, M; Betbeder-Matibet, O
2010-05-21
This Letter provides a formalism capable of exactly treating Pauli blocking between n-fermion particles. This formalism is based on an operator algebra made of commutators and anticommutators which contrasts with the usual scalar formalism of Green functions developed half a century ago for elementary quantum particles. We also provide the diagrams which visualize the very specific many-body physics induced by fermion exchanges between composite quantum particles.
Viewpoints, Formalisms, Languages, and Tools for Cyber-Physical Systems
2014-05-16
ACM, Inc., fax +1 (212) 869-0481. Formalisms Languages and ToolsViewpoints supported by implemented by based on Figure 1: Framework for Viewpoints...Description Languages Examples: VHDL , Verilog, and AMS extensions Reactive languages Examples: SCADE/Lustre and Giotto Model Checkers Examples: Spin, NuSMV...syntax and a formal semantics. Languages are con- crete implementations of formalisms. A language has a con- crete syntax, may deviate slightly from
Formalized Linear Algebra over Elementary Divisor Rings in Coq
Cano , Guillaume; Cohen , Cyril; Dénès , Maxime; Mörtberg , Anders; Siles , Vincent
2016-01-01
International audience; This paper presents a Coq formalization of linear algebra over elementary divisor rings, that is, rings where every matrix is equivalent to a matrix in Smith normal form. The main results are the formalization that these rings support essential operations of linear algebra, the classification theorem of finitely pre-sented modules over such rings and the uniqueness of the Smith normal form up to multiplication by units. We present formally verified algorithms comput-in...
Methyl mercury in terrestrial compartments
International Nuclear Information System (INIS)
Stoeppler, M.; Burow, M.; Padberg, S.; May, K.
1993-09-01
On the basis of the analytical methodology available at present the state of the art for the determination of total mercury and of various organometallic compounds of mercury in air, precipitation, limnic systems, soils, plants and biota is reviewed. This is followed by the presentation and discussion of examples for the data obtained hitherto for trace and ultratrace levels of total mercury and mainly methyl mercury in terrestrial and limnic environments as well as in biota. The data discussed stem predominantly from the past decade in which, due to significant methodological progress, many new aspects were elucidated. They include the most important results in this area achieved by the Research Centre (KFA) Juelich within the project 'Origin and Fate of Methyl Mercury' (contracts EV4V-0138-D and STEP-CT90-0057) supported by the Commission of the European Communities, Brussels. (orig.) [de
Formal and informal credit in four provinces of Vietnam
DEFF Research Database (Denmark)
Barslund, Mikkel; Tarp, Finn
2008-01-01
This paper uses a survey of 932 rural households to uncover how the rural credit market operates in Vietnam. Households obtain credit through formal and informal lenders. Formal loans are almost entirely for production and asset accumulation, while informal loans are used for consumption smoothen......This paper uses a survey of 932 rural households to uncover how the rural credit market operates in Vietnam. Households obtain credit through formal and informal lenders. Formal loans are almost entirely for production and asset accumulation, while informal loans are used for consumption...
Cohomology in the Pure Spinor Formalism for the Superstring
International Nuclear Information System (INIS)
Berkovits, Nathan
2000-01-01
A manifestly super-Poincare covariant formalism for the superstring has recently been constructed using a pure spinor variable. Unlike the covariant Green-Schwarz formalism, this new formalism is easily quantized with a BRST operator and tree-level scattering amplitudes have been evaluated in a manifestly covariant manner. In this paper, the cohomology of the BRST operator in the pure spinor formalism is shown to give the usual light-cone Green-Schwarz spectrum. Although the BRST operator does not directly involve the Virasoro constraint, this constraint emerges after expressing the pure spinor variable in terms of SO(8) variables. (author)
A diagrammatic construction of formal E-independent model hamiltonian
International Nuclear Information System (INIS)
Kvasnicka, V.
1977-01-01
A diagrammatic construction of formal E-independent model interaction (i.e., without second-quantization formalism) is suggested. The construction starts from the quasi-degenerate Brillouin-Wigner perturbation theory, in the framework of which an E-dependent model Hamiltonian is simply constructed. Applying the ''E-removing'' procedure to this E-dependent model Hamiltonian, the E-independent formal model Hamiltonian either Hermitian or non-Hermitian can diagrammatically be easily derived. For the formal E-independent model Hamiltonian the separability theorem is proved, which can be profitably used for a rather ''formalistic ''construction of a many-body E-independent model Hamiltonian
Formalizing a Paraconsistent Logic in the Isabelle Proof Assistant
DEFF Research Database (Denmark)
Villadsen, Jørgen; Schlichtkrull, Anders
2017-01-01
We present a formalization of a so-called paraconsistent logic that avoids the catastrophic explosiveness of inconsistency in classical logic. The paraconsistent logic has a countably infinite number of non-classical truth values. We show how to use the proof assistant Isabelle to formally prove...... theorems in the logic as well as meta-theorems about the logic. In particular, we formalize a meta-theorem that allows us to reduce the infinite number of truth values to a finite number of truth values, for a given formula, and we use this result in a formalization of a small case study....
Thermophysical study of methyl levulinate
International Nuclear Information System (INIS)
Lomba, Laura; Lafuente, Carlos; García-Mardones, Mónica; Gascón, Ignacio; Giner, Beatriz
2013-01-01
Highlights: • We have carried out a thermophysical characterization of methyl levulinate. • The study has been performed over a temperature range from (278.15 to 328.15) K. • pρT behavior has been studied over a temperature range from (333.15 to 453.15) K. • TRIDEN equation has been used to correlate pρT data. • Results have been compared with of ethyl and butyl levulinate and levulinic acid. -- Abstract: Several thermophysical properties (density, speed of sound, refractive index, surface tension, static permittivity and dynamic viscosity) of methyl levulinate have been measured under atmospheric pressure at temperatures from (278.15 to 338.15) K, while the vapor pressure was determined over a temperature range from (333.15 to 453.15) K. Furthermore, pρT behavior has been also investigated using a high-pressure, high-temperature vibrating tube densimeter over a temperature range from (283.15 to 338.15) K and a pressure range from (0.1 to 60.0) MPa. All these values obtained for methyl levulinate have been compared with other members of the levulinate family and also with levulinic acid
Results from the FIN-2 formal comparison
Connolly, Paul; Hoose, Corinna; Liu, Xiaohong; Moehler, Ottmar; Cziczo, Daniel; DeMott, Paul
2017-04-01
During the Fifth International Ice Nucleation Workshop (FIN-2) at the AIDA Ice Nucleation facility in Karlsruhe, Germany in March 2015, a formal comparison of ice nucleation measurement methods was conducted. During the experiments the samples of ice nucleating particles were not revealed to the instrument scientists, hence this was referred to as a "blind comparison". The two samples used were later revealed to be Arizona Test Dust and an Argentina soil sample. For these two samples seven mobile ice nucleating particle counters sampled directly from the AIDA chamber or from the aerosol preparation chamber at specified temperatures, whereas filter samples were taken for two offline deposition nucleation instruments. Wet suspension methods for determining IN concentrations were also used with 10 different methods employed. For the wet suspension methods experiments were conducted using INPs collected from the air inside the chambers (impinger sampling) and INPs taken from the bulk samples (vial sampling). Direct comparisons of the ice nucleating particle concentrations are reported as well as derived ice nucleation active site densities. The study highlights the difficulties in performing such analyses, but generally indicates that there is reasonable agreement between the wet suspension techniques. It is noted that ice nucleation efficiency derived from the AIDA chamber (quantified using the ice active surface site density approach) is higher than that for the cold stage techniques. This is both true for the Argentina soil sample and, to a lesser extent, for the Arizona Test Dust sample too. Other interesting effects were noted: for the ATD the impinger sampling demonstrated higher INP efficiency at higher temperatures (>255 K) than the vial sampling, but agreed at the lower temperatures (<255K), whereas the opposite was true for the Argentina soil sample. The results are analysed to better understand the performance of the various techniques and to address any
A formal model of interpersonal inference
Directory of Open Access Journals (Sweden)
Michael eMoutoussis
2014-03-01
Full Text Available Introduction: We propose that active Bayesian inference – a general framework for decision-making – can equally be applied to interpersonal exchanges. Social cognition, however, entails special challenges. We address these challenges through a novel formulation of a formal model and demonstrate its psychological significance. Method: We review relevant literature, especially with regards to interpersonal representations, formulate a mathematical model and present a simulation study. The model accommodates normative models from utility theory and places them within the broader setting of Bayesian inference. Crucially, we endow people's prior beliefs, into which utilities are absorbed, with preferences of self and others. The simulation illustrates the model's dynamics and furnishes elementary predictions of the theory. Results: 1. Because beliefs about self and others inform both the desirability and plausibility of outcomes, in this framework interpersonal representations become beliefs that have to be actively inferred. This inference, akin to 'mentalising' in the psychological literature, is based upon the outcomes of interpersonal exchanges. 2. We show how some well-known social-psychological phenomena (e.g. self-serving biases can be explained in terms of active interpersonal inference. 3. Mentalising naturally entails Bayesian updating of how people value social outcomes. Crucially this includes inference about one’s own qualities and preferences. Conclusion: We inaugurate a Bayes optimal framework for modelling intersubject variability in mentalising during interpersonal exchanges. Here, interpersonal representations are endowed with explicit functional and affective properties. We suggest the active inference framework lends itself to the study of psychiatric conditions where mentalising is distorted.
Nuclear magnetic relaxation of methyl group in liquids
International Nuclear Information System (INIS)
Blicharska, B.
1986-01-01
The theoretical description of the relaxation process of methyl group in liquids and some results of the measurements of relaxation function and relaxation times for cryoprotective solutions are presented. Starting from the application of the operator formalism the general equation for spin operators e.g. components of the nuclear spin and magnetization is founded. Next, the spin Hamiltonian is presented as contraction of the symmetry adapted spherical tensors as well as the correlation functions and spectral densities. On the basis of extended and modified Woessner model of motion the correlation functions and spectral densities are calculated for methyl group in liquids. Using these functions the relaxation matrix elements, the spin-spin and spin-lattice relaxation times can be expressed. The prediction of the theory agrees with author's previous experiments on cryoprotective solutions. The observed dependence on temperature, frequency and isotopic dilution in methanol-water, methanol-dimethyl sulfoxide (DMSO) and DMSO-water solutions is in a satisfactory agreement with theoretical equations. 34 refs. (author)
Evolution of DNA Methylation across Insects.
Bewick, Adam J; Vogel, Kevin J; Moore, Allen J; Schmitz, Robert J
2017-03-01
DNA methylation contributes to gene and transcriptional regulation in eukaryotes, and therefore has been hypothesized to facilitate the evolution of plastic traits such as sociality in insects. However, DNA methylation is sparsely studied in insects. Therefore, we documented patterns of DNA methylation across a wide diversity of insects. We predicted that underlying enzymatic machinery is concordant with patterns of DNA methylation. Finally, given the suggestion that DNA methylation facilitated social evolution in Hymenoptera, we tested the hypothesis that the DNA methylation system will be associated with presence/absence of sociality among other insect orders. We found DNA methylation to be widespread, detected in all orders examined except Diptera (flies). Whole genome bisulfite sequencing showed that orders differed in levels of DNA methylation. Hymenopteran (ants, bees, wasps and sawflies) had some of the lowest levels, including several potential losses. Blattodea (cockroaches and termites) show all possible patterns, including a potential loss of DNA methylation in a eusocial species whereas solitary species had the highest levels. Species with DNA methylation do not always possess the typical enzymatic machinery. We identified a gene duplication event in the maintenance DNA methyltransferase 1 (DNMT1) that is shared by some Hymenoptera, and paralogs have experienced divergent, nonneutral evolution. This diversity and nonneutral evolution of underlying machinery suggests alternative DNA methylation pathways may exist. Phylogenetically corrected comparisons revealed no evidence that supports evolutionary association between sociality and DNA methylation. Future functional studies will be required to advance our understanding of DNA methylation in insects. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
Olejniczak, E; Lee, H J
1984-06-01
The systemic activities of methyl prednisolonate and methyl 17-deoxyprednisolonate (1) were studied in rats. Methyl 17-deoxyprednisolonate produced significant changes in the amount of sodium ion (decreased) and potassium ion (increased) in urine; however, methyl prednisolonate had no effect on electrolyte balance. Both methyl prednisolonate and methyl 17-deoxyprednisolonate had no effect on liver glycogen content, plasma corticosterone level and relative adrenal weight. In contrast, the parent compound prednisolone caused a significant decrease in liver glycogen content, plasma corticosterone level and relative adrenal weight.
Informal Risk Perceptions and Formal Theory
International Nuclear Information System (INIS)
Cayford, Jerry
2001-01-01
Economists have argued persuasively that our goals are wider than just risk minimization, and that they include a prudent weighing of costs and benefits. This economic line of thought recognizes that our policy goals are complex. As we widen the range of goals we are willing to entertain, though, we need to check that the methods we customarily employ are appropriate for the tasks to which we customarily apply them. This paper examines some economic methods of risk assessment, in light of the question of what our policy goals are and should be. Once the question of goals is open, more complexities than just cost intrude: what the public wants and why begs to be addressed. This leads us to the controversial issue of public risk perceptions. We have now examined a number of procedures that experts use to make public policy decisions. Behind all these issues is always the question of social welfare: what actions can we take, what policies should we embrace, to make the world a better place? In many cases, the public and the experts disagree about what the right choice is. In the first section, we saw a possible defense of the experts based on democratic theory: the people's participation, and even their will, can be legitimately set aside in the pursuit of their true interests. If this defense is to work, a great deal of weight rests on the question of the people's interests and the competence and integrity of the experts' pursuit of it. But at the same time, social preferences are ill-defined, and so are not good candidates for rational actor theory. Both the prescriptive legitimacy claim and the very workings of formal theory we have seen to depend on informal, qualitative, political judgments. Unfortunately, we have also seen a steady pattern of expert reliance on technical procedures even when they were manifestly unsuited to the task. The experts seem so intent on excluding informal thought that they would prefer even a bad quantitative process to a qualitative
Informal Risk Perceptions and Formal Theory
Energy Technology Data Exchange (ETDEWEB)
Cayford, Jerry [Resources for the Future, Washington, DC (United States)
2001-07-01
Economists have argued persuasively that our goals are wider than just risk minimization, and that they include a prudent weighing of costs and benefits. This economic line of thought recognizes that our policy goals are complex. As we widen the range of goals we are willing to entertain, though, we need to check that the methods we customarily employ are appropriate for the tasks to which we customarily apply them. This paper examines some economic methods of risk assessment, in light of the question of what our policy goals are and should be. Once the question of goals is open, more complexities than just cost intrude: what the public wants and why begs to be addressed. This leads us to the controversial issue of public risk perceptions. We have now examined a number of procedures that experts use to make public policy decisions. Behind all these issues is always the question of social welfare: what actions can we take, what policies should we embrace, to make the world a better place? In many cases, the public and the experts disagree about what the right choice is. In the first section, we saw a possible defense of the experts based on democratic theory: the people's participation, and even their will, can be legitimately set aside in the pursuit of their true interests. If this defense is to work, a great deal of weight rests on the question of the people's interests and the competence and integrity of the experts' pursuit of it. But at the same time, social preferences are ill-defined, and so are not good candidates for rational actor theory. Both the prescriptive legitimacy claim and the very workings of formal theory we have seen to depend on informal, qualitative, political judgments. Unfortunately, we have also seen a steady pattern of expert reliance on technical procedures even when they were manifestly unsuited to the task. The experts seem so intent on excluding informal thought that they would prefer even a bad quantitative process to
Formal structures for extracting analytically justifiable decisions from ...
African Journals Online (AJOL)
This paper identifies the benefits of transforming business process models into Decision Support Systems (DSS). However, the literature reveals that a business process model “should have a formal foundation” as a major requirement for transforming it into a DSS. The paper further ascertains that formal structures refer to ...
The nature of Formal Reasoning among Ghanaian Basic School ...
African Journals Online (AJOL)
Many Psychologists have considered early formal thinking among adolescents as signs of normal development. As it is not known for certain at what age Ghanaian Junior Secondary School (JSS) pupils achieve formal operational capabilities, the study seeks to find out the relationship between Piagetian theory of ...
Formal Methods and Safety Certification: Challenges in the Railways Domain
DEFF Research Database (Denmark)
Fantechi, Alessandro; Ferrari, Alessio; Gnesi, Stefania
2016-01-01
The railway signalling sector has historically been a source of success stories about the adoption of formal methods in the certification of software safety of computer-based control equipment.......The railway signalling sector has historically been a source of success stories about the adoption of formal methods in the certification of software safety of computer-based control equipment....
Formalities in the digital era: an obstacle or opportunity?
van Gompel, S.; Bently, L.; Suthersanen, U.; Torremans, P.
2010-01-01
This paper, which was presented at the 2009 ALAI conference in London, examines the possible reintroduction of copyright formalities against the background of the challenges that copyright law faces in the digital era. It does so by contrasting the current calls for reintroducing formalities with
Academic Achievement and Formal Thought in Engineering Students
Vazquez, Stella Maris; de Anglat, Hilda Difabio
2009-01-01
Introduction: Research on university-level academic performance has significantly linked failure and dropping out to formal reasoning deficiency. We have not found any papers on formal thought in Argentine university students, in spite of the obvious shortcomings observed in the classrooms. Thus, the main objective of this paper was exploring the…
Formalized Verification of Snapshotable Trees: Separation and Sharing
DEFF Research Database (Denmark)
Mehnert, Hannes; Sieczkowski, Filip; Birkedal, Lars
2012-01-01
We use separation logic to specify and verify a Java program that implements snapshotable search trees, fully formalizing the speci- cation and verication in the Coq proof assistant. We achieve local and modular reasoning about a tree and its snapshots and their iterators, al- though...... for full functional specication and verication, whether by separation logic or by other formalisms....
Formal equivalence of Poisson structures around Poisson submanifolds
Marcut, I.T.
2012-01-01
Let (M,π) be a Poisson manifold. A Poisson submanifold P ⊂ M gives rise to a Lie algebroid AP → P. Formal deformations of π around P are controlled by certain cohomology groups associated to AP. Assuming that these groups vanish, we prove that π is formally rigid around P; that is, any other Poisson
On the Formal Integrability Problem for Planar Differential Systems
Directory of Open Access Journals (Sweden)
Antonio Algaba
2013-01-01
Full Text Available We study the analytic integrability problem through the formal integrability problem and we show its connection, in some cases, with the existence of invariant analytic (sometimes algebraic curves. From the results obtained, we consider some families of analytic differential systems in ℂ2, and imposing the formal integrability we find resonant centers obviating the computation of some necessary conditions.
Moderation instead of modelling: some arguments against formal engineering methods
Rauterberg, G.W.M.; Sikorski, M.; Rauterberg, G.W.M.
1998-01-01
The more formal the used engineering techniques are, the less non-technical facts can be captured. Several business process reengineering and software development projects fail, because the project management concentrates to much on formal methods and modelling approaches. A successful change of
Non-Formal Education: Interest in Human Capital
Ivanova, I. V.
2016-01-01
We define non-formal education as a part of general education, which gives students the required tools for cognition and creativity. It allows them to fully realize their self-potential and to set their own professional and personal goals. In this article, we outline the fundamental differences between general and non-formal education from the…
Traditional and formal education: Means of improving grasscutter ...
African Journals Online (AJOL)
The study concludes that both traditional and non-formal education are important for the development and efficiency of grasscutter farming in Ogun Waterside Local Government Area of Ogun State. The following are the recommendations of the study: revision of the curriculum of formal schools to include items that inculcate ...
A Comparative Study on the Influence of Formal (School) Career ...
African Journals Online (AJOL)
A Comparative Study on the Influence of Formal (School) Career Guidance and Non-Formal (Parents) Career Guidance on Secondary School Students' ... These participants were purposively selected from a population of four research sites in Harare; (Ministry of education, Ministry of health, Business office and industry).
Financing Adult and Non-Formal Education in Nigeria
Hassan, Moshood Ayinde
2009-01-01
The purpose of this study is to determine how adult and non formal education is financed in Nigeria; and to examine areas or forms of and the problems of financing adult and non-formal education in Nigeria. Survey research was used in order to carry out the study. Three hundred and twenty five (325) respondents from government agencies,…
The higher returns to formal education for entrepreneurs versus employees
van Praag, M.; van Witteloostuijn, A.; van der Sluis, J.
2013-01-01
How valuable is formal education for entrepreneurs’ income relative to employees’? And if the income returns to formal education are different for entrepreneurs vis-à-vis employees, what might be a plausible explanation? To explore these questions, we analyze a large representative US panel. We show
A formalization of the Berlekamp-Zassenhaus factorization algorithm
Divasón, Jose; Joosten, Sebastiaan; Thiemann, René; Yamada, Akihisa
2017-01-01
We formalize the Berlekamp–Zassenhaus algorithm for factoring square-free integer polynomials in Isabelle/HOL. We further adapt an existing formalization of Yun’s square-free factorization algorithm to integer polynomials, and thus provide an efficient and certified factorization algorithm for
Formal concept analysis in knowledge discovery: A survey
Poelmans, J.; Elzinga, P.; Viaene, S.; Dedene, G.; Croitoru, M.; Ferré, S.; Lukose, D.
2010-01-01
In this paper, we analyze the literature on Formal Concept Analysis (FCA) using FCA. We collected 702 papers published between 2003-2009 mentioning Formal Concept Analysis in the abstract. We developed a knowledge browsing environment to support our literature analysis process. The pdf-files
Formal description of the OSI session layer: introduction
Ajubi, I.; Scollo, Giuseppe; van Sinderen, Marten J.; van Eijk, P.H.J.; Vissers, C.A.; Diaz, M.
1989-01-01
The LOTOS formal description of the OSI session layer is introduced with the purpose of familiarizing the reader with the design choices that influenced the development of the formal description. Such design choices concern the adoptation of specification styles and the reflection of elements of the
Y-formalism and curved {beta}-{gamma} systems
Energy Technology Data Exchange (ETDEWEB)
Grassi, Pietro Antonio [DISTA, Universita del Piemonte Orientale, via Bellini 25/g, 15100 Alessandria (Italy); INFN - Sezione di Torino (Italy)], E-mail: antonio.pietro.grassi@cern.ch; Oda, Ichiro [Department of Physics, Faculty of Science, University of the Ryukyus, Nishihara, Okinawa 903-0213 (Japan); Tonin, Mario [Dipartimento di Fisica, Universita degli Studi di Padova, INFN, Sezionedi Padova, Via F. Marzolo 8, 35131 Padova (Italy)
2009-01-01
We adopt the Y-formalism to study {beta}-{gamma} systems on hypersurfaces. We compute the operator product expansions of gauge-invariant currents and we discuss some applications of the Y-formalism to model on Calabi-Yau spaces.
Y-formalism and curved β-γ systems
International Nuclear Information System (INIS)
Grassi, Pietro Antonio; Oda, Ichiro; Tonin, Mario
2009-01-01
We adopt the Y-formalism to study β-γ systems on hypersurfaces. We compute the operator product expansions of gauge-invariant currents and we discuss some applications of the Y-formalism to model on Calabi-Yau spaces
Lekhnitskii's formalism of one-dimensional quasicrystals and its ...
Indian Academy of Sciences (India)
To illustrate its utility, the generalized Lekhnitskii's formal- ism is used to analyse the coupled phonon and phason fields in an infinite quasicrystal medium con- taining an elliptic rigid inclusion. Keywords. Generalized Lekhnitskii's formalism; one-dimensional quasicrystals; plane problems; elliptic inclusion. PACS Nos 61.44.
Blending Formal and Informal Learning Networks for Online Learning
Czerkawski, Betül C.
2016-01-01
With the emergence of social software and the advance of web-based technologies, online learning networks provide invaluable opportunities for learning, whether formal or informal. Unlike top-down, instructor-centered, and carefully planned formal learning settings, informal learning networks offer more bottom-up, student-centered participatory…
Formal Test Automation: The Conference Protocol with PHACT
Heerink, A.W.; Ural, Hasan; Probert, Robert L.; Feenstra, J.; Tretmans, G.J.; von Bochmann, Gregor
2000-01-01
We discuss a case study of automatic test generation and test execution based on formal methods. The case is the Conference Protocol, a simple, chatbox-like protocol, for which (formal) specifications and multiple implementations are publicly available and which is also used in other case study
Enhancing Formal E-Learning with Edutainment on Social Networks
Labus, A.; Despotovic-Zrakic, M.; Radenkovic, B.; Bogdanovic, Z.; Radenkovic, M.
2015-01-01
This paper reports on the investigation of the possibilities of enhancing the formal e-learning process by harnessing the potential of informal game-based learning on social networks. The goal of the research is to improve the outcomes of the formal learning process through the design and implementation of an educational game on a social network…
How Online Journalists Learn within a Non-Formal Context
Kronstad, Morten; Eide, Martin
2015-01-01
Purpose: The purpose of this paper is to contribute to the understanding of workplace learning, with a focus on the non-formal learning that takes place among online journalists. The focus of this article is journalists working in an online newspaper and their experiences with workplace and non-formal learning, centering on framework conditions…
Recognising Non-Formal and Informal Learning: An Open Challenge
Perulli, Elisabetta
2009-01-01
The social-institutional endorsement towards the perspective of recognising and enhancing learning acquired outside the formal education and training contexts (non-formal and informal learning), has been gaining strength and has entered policy agendas throughout Europe, but also in other major non-European countries. Nevertheless there are still…
The development of mobile computation and the related formal description
International Nuclear Information System (INIS)
Jin Yan; Yang Xiaozong
2003-01-01
The description and research for formal representation in mobile computation, which is very instructive to resolve the status transmission, domain administration, authentication. This paper presents the descriptive communicating process and computational process from the view of formal calculus, what's more, it construct a practical application used by mobile ambient. Finally, this dissertation shows the future work and direction. (authors)
On the Equivalence of Formal Grammars and Machines.
Lund, Bruce
1991-01-01
Explores concepts of formal language and automata theory underlying computational linguistics. A computational formalism is described known as a "logic grammar," with which computational systems process linguistic data, with examples in declarative and procedural semantics and definite clause grammars. (13 references) (CB)
Curiosity: A Prerequisite for the Attainment of Formal Operations?
Hawkins, Vincent J.
1982-01-01
Research on Piaget's four stages of cognitive development has shown that although nearly everyone passes through sensorimotor, preoperational, and concrete operational stages, most do not reach the stage of formal operations. Those people who do attain formal operations seem to have a curiosity factor not operative in those who don't. (Author/BRR)
Relating Lagrangian and Hamiltonian Formalisms of LC Circuits
Clemente-Gallardo, Jesús; Scherpen, Jacquelien M.A.
2003-01-01
The Lagrangian formalism earlier defined for (switching) electrical circuits, is adapted to the Lagrangian formalism defined on Lie algebroids. This allows us to define regular Lagrangians and consequently, well-defined Hamiltonian descriptions of arbitrary LC networks. The relation with other
The Formalization of Cultural Psychology. Reasons and Functions.
Salvatore, Sergio
2017-03-01
In this paper I discuss two basic theses about the formalization of cultural psychology. First, I claim that formalization is a relevant, even necessary stage of development of this domain of science. This is so because formalization allows the scientific language to achieve a much needed autonomy from the commonsensical language of the phenomena that this science deals with. Second, I envisage the two main functions that formalization has to perform in the field of cultural psychology: on the one hand, it has to provide formal rules grounding and constraining the deductive construction of the general theory; on the other hand, it has to provide the devices for supporting the interpretation of local phenomena, in terms of the abductive reconstruction of the network of linkages among empirical occurrences comprising the local phenomena.
Do formal management practices impact the emergence of bootlegging behavior?
DEFF Research Database (Denmark)
Globocnik, Dietfried; Salomo, Søren
2014-01-01
behavior, research has barely addressed the antecedents of this deviance. Drawing on strain theory and social cognitive theory, we study whether the emergence of bootlegging behavior is influenced by formal management practices, in particular, strategic autonomy, front-end formality, rewards, and sanctions......Innovation in an organization often relies on initiatives by employees who take action to develop their ideas and obtain buy-in by organizational decision-makers. To achieve this, employees sometimes apply unorthodox approaches, ignoring formal structures to further elaborate their ideas' potential...... and promote their implementation. They work without formal legitimacy and gather their own resources until sufficient clarity allows for informed decisions. Finally, they bypass formal communication channels to convince top management of the merits of their ideas. Despite the significance of such bootlegging...
Balancing Formality and Informality in Business Exchanges as a Duality
DEFF Research Database (Denmark)
Lin, Daomi; Lu, Jiangyong; Li, Peter Ping
2015-01-01
emphasized formality more than informality, while local entrepreneurs stressed informality more than formality. However, the formality-informality balance among both returnee and local entrepreneurs converged over time in line with the institutional transition in China. Returnee entrepreneurs increased...... for firms, especially those facing institutional differences in transnational contexts and institutional transitions. In this research, we conducted a comparative multicase study on returnee entrepreneurs and local entrepreneurs in China. We found that at the early stage of venturing, returnee entrepreneurs...... the emphasis on informality (but kept the dominant position of formality), whereas local entrepreneurs gradually shifted from informality to formality. The spatial pattern of asymmetrical balancing and the temporal pattern of transitional balancing are both rooted in the Chinese philosophy of Yin...
FORMS OF LEARNING WITHIN HIGHER EDUCATION. BLENDING FORMAL, INFORMAL AND NON-FORMAL
Directory of Open Access Journals (Sweden)
Irina- Teodora MANOLESCU
2018-07-01
Full Text Available Changes that occur in the socio-economic environment determine new challenges for individuals that strive to acquire new, more valuable competencies. The universities, considered one of the most important pillars in developing such competencies, are challenged to develop and harmonize different forms of education (formal, informal and non-formal in order to respond to individuals’ and organizations’ needs. The mixture of learning forms can bring competitive advantage for the universities. However mixing the learning forms is not so easy to accomplish, considering that the stakeholders’ requirements could be divergent and the resources are limited. This paper aims at presenting the advantages and disadvantages of these forms of learning and also outlines few examples of the interferences. At last, the paper presents some preliminary results of a quantitative research regarding the perception on the usage of the three forms of learning of one of its stakeholders - the higher education candidates. Some implications for both universities and high school education are highlighted.
Methylation patterns in marginal zone lymphoma.
Arribas, Alberto J; Bertoni, Francesco
Promoter DNA methylation is a major regulator of gene expression and transcription. The identification of methylation changes is important for understanding disease pathogenesis, for identifying prognostic markers and can drive novel therapeutic approaches. In this review we summarize the current knowledge regarding DNA methylation in MALT lymphoma, splenic marginal zone lymphoma, nodal marginal zone lymphoma. Despite important differences in the study design for different publications and the existence of a sole large and genome-wide methylation study for splenic marginal zone lymphoma, it is clear that DNA methylation plays an important role in marginal zone lymphomas, in which it contributes to the inactivation of tumor suppressors but also to the expression of genes sustaining tumor cell survival and proliferation. Existing preclinical data provide the rationale to target the methylation machinery in these disorders. Copyright © 2016 Elsevier Ltd. All rights reserved.
Wp specific methylation of highly proliferated LCLs
International Nuclear Information System (INIS)
Park, Jung-Hoon; Jeon, Jae-Pil; Shim, Sung-Mi; Nam, Hye-Young; Kim, Joon-Woo; Han, Bok-Ghee; Lee, Suman
2007-01-01
The epigenetic regulation of viral genes may be important for the life cycle of EBV. We determined the methylation status of three viral promoters (Wp, Cp, Qp) from EBV B-lymphoblastoid cell lines (LCLs) by pyrosequencing. Our pyrosequencing data showed that the CpG region of Wp was methylated, but the others were not. Interestingly, Wp methylation was increased with proliferation of LCLs. Wp methylation was as high as 74.9% in late-passage LCLs, but 25.6% in early-passage LCLs. From two Burkitt's lymphoma cell lines, Wp specific hypermethylation was also found (>80%). Interestingly, the expression of EBNA2 gene which located directly next to Wp was associated with its methylation. Our data suggested that Wp specific methylation may be important for the indicator of the proliferation status of LCLs, and the epigenetic viral gene regulation of EBNA2 gene by Wp should be further defined possibly with other biological processes
Saif, Perveen; Reba, Amjad; ud Din, Jalal
2017-01-01
This study was designed to compare the subject knowledge of B.Ed graduates of formal and non-formal teacher education systems. The population of the study included all teachers from Girls High and Higher Secondary Schools both from private and public sectors from the district of Peshawar. Out of the total population, twenty schools were randomly…
Zamora, Julieta Lopez; Reynaga, Francisco Javier Arriaga
2010-01-01
This paper presents results of two research works, the first approaches non-formal education and the second addresses formal education. In both studies in-depth interview techniques were used. There were some points of convergence between them on aspects such as the implementation of learning environments and the integration of ICT. The interview…
Structure, bioactivity, and synthesis of methylated flavonoids.
Wen, Lingrong; Jiang, Yueming; Yang, Jiali; Zhao, Yupeng; Tian, Miaomiao; Yang, Bao
2017-06-01
Methylated flavonoids are an important type of natural flavonoid derivative with potentially multiple health benefits; among other things, they have improved bioavailability compared with flavonoid precursors. Flavonoids have been documented to have broad bioactivities, such as anticancer, immunomodulation, and antioxidant activities, that can be elevated, to a certain extent, by methylation. Understanding the structure, bioactivity, and bioavailability of methylated flavonoids, therefore, is an interesting topic with broad potential applications. Though methylated flavonoids are widely present in plants, their levels are usually low. Because developing efficient techniques to produce these chemicals would likely be beneficial, we provide an overview of their chemical and biological synthesis. © 2017 New York Academy of Sciences.
Colorectal Cancer "Methylator Phenotype": Fact or Artifact?
Directory of Open Access Journals (Sweden)
Charles Anacleto
2005-04-01
Full Text Available It has been proposed that human colorectal tumors can be classified into two groups: one in which methylation is rare, and another with methylation of several loci associated with a "CpG island methylated phenotype (CIMP," characterized by preferential proximal location in the colon, but otherwise poorly defined. There is considerable overlap between this putative methylator phenotype and the well-known mutator phenotype associated with microsatellite instability (MSI. We have examined hypermethylation of the promoter region of five genes (DAPK, MGMT, hMLH1, p16INK4a, and p14ARF in 106 primary colorectal cancers. A graph depicting the frequency of methylated loci in the series of tumors showed a continuous, monotonically decreasing distribution quite different from the previously claimed discontinuity. We observed a significant association between the presence of three or more methylated loci and the proximal location of the tumors. However, if we remove from analysis the tumors with hMLH1 methylation or those with MSI, the significance vanishes, suggesting that the association between multiple methylations and proximal location was indirect due to the correlation with MSI. Thus, our data do not support the independent existence of the so-called methylator phenotype and suggest that it rather may represent a statistical artifact caused by confounding of associations.
Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence
Directory of Open Access Journals (Sweden)
Mark Lucock
2015-06-01
Conclusion: A methylation diet influences methyl group synthesis in the regulation of blood homocysteine level, and is modulated by genetic interactions. Methylation-related nutrients also interact with key genes to modify risk of AP, a precursor of colorectal cancer. Independent of diet, two methylation-related genes (A2756G-MS and A66G-MSR were directly associated with AP occurrence.
Preparation and Characterization of Formalated Polyvinyl Alcohol Hydrogel Film
International Nuclear Information System (INIS)
Than Than Aye; Nyunt Win; San Myint
2011-12-01
A feasible hydrogen film was prepared from polyvinyl alcohol (PVA) sample. The effect of chemical grafting on polyvinyl alcohol film was studied. Polyvinyl alcohol sample was mixed with distilled water and autoclaved at 121C for 60 minutes. An aqueous solution of polyvinyl alcohol was casted into a steel plate and dried for a certain time at room temperature. The obtained PVA film was immersed in formalation bath containing aqueous formaldehyde, sulphuric acid, anhydrous sodium sulphate with a weight ratio of (64:95:300) and 1 liter of distilled water at 60C for various hours. Effect of formalation time was studied varying 6, 12, 24, 36 and 48 hours. Degree of formalation was also evaluated. Physical properties of the hydrogel film such as gel fraction, degree of swelling and mechanical properties such as tensile strength, elongation and hardness were determined before and after formalation of the PVA film. Fourier Transform Infrared Spectroscopic (FTIR) analysis, Thermogravimetric / Differential thermal analysis (DTA / TG) were also studied for characterization. It was found that the appropriate condition for formalation was occured at 24 hours formalation time of with the calculated degree of formalation 65.35% with the determined values (9.04 Mpa) for tensile strength, (241.92%) for elongation, (45.30 Shore D) for hardness, (280.36%) for degree of swelling and (68.32%) for gel fraction.
A genome-wide methylation study on obesity Differential variability and differential methylation
Xu, Xiaojing; Su, Shaoyong; Barnes, Vernon A.; De Miguel, Carmen; Pollock, Jennifer; Ownby, Dennis; Shi, Huidong; Zhu, Haidong; Snieder, Harold; Wang, Xiaoling
2013-01-01
Besides differential methylation, DNA methylation variation has recently been proposed and demonstrated to be a potential contributing factor to cancer risk. Here we aim to examine whether differential variability in methylation is also an important feature of obesity, a typical non-malignant common
21 CFR 177.2000 - Vinylidene chloride/methyl acrylate/methyl methacrylate polymers.
2010-04-01
... methacrylate polymers. 177.2000 Section 177.2000 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF...: POLYMERS Substances for Use as Basic Components of Single and Repeated Use Food Contact Surfaces § 177.2000 Vinylidene chloride/methyl acrylate/methyl methacrylate polymers. The vinylidene chloride/methyl acrylate...
Directory of Open Access Journals (Sweden)
Daniel Dominguez
2014-07-01
Full Text Available As a result of the increasing use of mobile devices in education, new approaches to define the learning competences in the field of digitally mediated learning have emerged. This paper examines these approaches, using data obtained from empirical research with a group of Spanish university students. The analysis is focused on the experiences of students in the use of mobile devices in both formal and open-informal educational contexts. The theoretical framework of the study is based on the ecological focus applied to explanatory models of digital literacy. As a result of the data it is possible to study this framework in depth, taking into account the theories defending an open view of digital literacy. The study may be of interest to instructional designers and researchers in the fields of open educational resources and technologies applied to education in open contexts.
Formal and Informal Rural Credit in Four Provinces of Vietnam
DEFF Research Database (Denmark)
Barslund, Mikkel Christoffer; Tarp, Finn
This paper uses a survey of 932 rural households to uncover how the rural credit market operates in four provinces of Vietnam. Households obtain credit through formal and informal lenders. Formal loans are almost entirely for production and asset accumulation, while informal loans are used...... for consumption smoothening. Interest rates fell from 1997 to 2002, reflecting increased market integration. Moreover, the determinants of formal and informal credit demand are distinct. While credit rationing depends on education and credit history, in particular, regional differences in the demand for credit...
Formalizing Implementation Strategies for First-Class Continuations
DEFF Research Database (Denmark)
Danvy, Olivier
1999-01-01
We present the first formalization of implementation strategies for first-class continuations. The formalization hinges on abstract machines for continuation-passing style (CPS) programs with a special treatment for the current continuation, accounting for the essence of first-class continuations......-class continuations and that second-class continuations are stackable. A large body of work exists on implementing continuations, but it is predominantly empirical and implementation-oriented. In contrast, our formalization abstracts the essence of first-class continuations and provides a uniform setting...
Formalizing Implementation Strategies for First-Class Continuations
DEFF Research Database (Denmark)
Danvy, Olivier
2000-01-01
We present the first formalization of implementation strategies for first-class continuations. The formalization hinges on abstract machines for continuation-passing style (CPS) programs with a special treatment for the current continuation, accounting for the essence of first-class continuations......-class continuations and that second-class continuations are stackable. A large body of work exists on implementing continuations, but it is predominantly empirical and implementation-oriented. In contrast, our formalization abstracts the essence of first-class continuations and provides a uniform setting...
A Synthesized Framework for Formal Verification of Computing Systems
Directory of Open Access Journals (Sweden)
Nikola Bogunovic
2003-12-01
Full Text Available Design process of computing systems gradually evolved to a level that encompasses formal verification techniques. However, the integration of formal verification techniques into a methodical design procedure has many inherent miscomprehensions and problems. The paper explicates the discrepancy between the real system implementation and the abstracted model that is actually used in the formal verification procedure. Particular attention is paid to the seamless integration of all phases of the verification procedure that encompasses definition of the specification language and denotation and execution of conformance relation between the abstracted model and its intended behavior. The concealed obstacles are exposed, computationally expensive steps identified and possible improvements proposed.
Transforming PLC Programs into Formal Models for Verification Purposes
Darvas, D; Blanco, E
2013-01-01
Most of CERN’s industrial installations rely on PLC-based (Programmable Logic Controller) control systems developed using the UNICOS framework. This framework contains common, reusable program modules and their correctness is a high priority. Testing is already applied to find errors, but this method has limitations. In this work an approach is proposed to transform automatically PLC programs into formal models, with the goal of applying formal verification to ensure their correctness. We target model checking which is a precise, mathematical-based method to check formalized requirements automatically against the system.
Machine Learning-based Intelligent Formal Reasoning and Proving System
Chen, Shengqing; Huang, Xiaojian; Fang, Jiaze; Liang, Jia
2018-03-01
The reasoning system can be used in many fields. How to improve reasoning efficiency is the core of the design of system. Through the formal description of formal proof and the regular matching algorithm, after introducing the machine learning algorithm, the system of intelligent formal reasoning and verification has high efficiency. The experimental results show that the system can verify the correctness of propositional logic reasoning and reuse the propositional logical reasoning results, so as to obtain the implicit knowledge in the knowledge base and provide the basic reasoning model for the construction of intelligent system.
Formal methods for dependable real-time systems
Rushby, John
1993-01-01
The motivation for using formal methods to specify and reason about real time properties is outlined and approaches that were proposed and used are sketched. The formal verifications of clock synchronization algorithms are concluded as showing that mechanically supported reasoning about complex real time behavior is feasible. However, there was significant increase in the effectiveness of verification systems since those verifications were performed, at it is to be expected that verifications of comparable difficulty will become fairly routine. The current challenge lies in developing perspicuous and economical approaches to the formalization and specification of real time properties.
Ichimura, Norihisa; Shinjo, Keiko; An, Byonggu; Shimizu, Yasuhiro; Yamao, Kenji; Ohka, Fumiharu; Katsushima, Keisuke; Hatanaka, Akira; Tojo, Masayuki; Yamamoto, Eiichiro; Suzuki, Hiromu; Ueda, Minoru; Kondo, Yutaka
2015-08-01
Inactivation of methylcytosine dioxygenase, ten-eleven translocation (TET) is known to be associated with aberrant DNA methylation in cancers. Tumors with a CpG island methylator phenotype (CIMP), a distinct subgroup with extensive DNA methylation, show characteristic features in the case of colorectal cancer. The relationship between TET inactivation and CIMP in colorectal cancers is not well understood. The expression level of TET family genes was compared between CIMP-positive (CIMP-P) and CIMP-negative (CIMP-N) colorectal cancers. Furthermore, DNA methylation profiling, including assessment of the TET1 gene, was assessed in colorectal cancers, as well as colon polyps. The TET1 was silenced by DNA methylation in a subset of colorectal cancers as well as cell lines, expression of which was reactivated by demethylating agent. TET1 methylation was more frequent in CIMP-P (23/55, 42%) than CIMP-N (2/113, 2%, P CIMP-P, 16/40, 40%; CIMP-N, 2/24, 8%; P = 0.002), suggesting that TET1 methylation is an early event in CIMP tumorigenesis. TET1 methylation was significantly associated with BRAF mutation but not with hMLH1 methylation in the CIMP-P colorectal cancers. Colorectal cancers with TET1 methylation have a significantly greater number of DNA methylated genes and less pathological metastasis compared to those without TET1 methylation (P = 0.007 and 0.045, respectively). Our data suggest that TET1 methylation may contribute to the establishment of a unique pathway in respect to CIMP-mediated tumorigenesis, which may be incidental to hMLH1 methylation. In addition, our findings provide evidence that TET1 methylation may be a good biomarker for the prediction of metastasis in colorectal cancer. ©2015 American Association for Cancer Research.
The Synthesis of Methyl Salicylate: Amine Diazotization.
Zanger, Murray; McKee, James R.
1988-01-01
Notes that this experiment takes safety and noncarcinogenic reactants into account. Demonstrates the use of diazonium salts for the replacement of an aromatic amine group by a phenolic hydroxyl. Involves two pleasant-smelling organic compounds, methyl anthranilate (grape) and methyl salicylate (oil of wintergreen). (MVL)
Evidence Suggesting Absence of Mitochondrial DNA Methylation
DEFF Research Database (Denmark)
Mechta, Mie; Ingerslev, Lars R; Fabre, Odile
2017-01-01
, 16S, ND5 and CYTB, suggesting that mtDNA supercoiled structure blocks the access to bisulfite conversion. Here, we identified an artifact of mtDNA bisulfite sequencing that can lead to an overestimation of mtDNA methylation levels. Our study supports that cytosine methylation is virtually absent...
DNA Methylation Modulates Nociceptive Sensitization after Incision.
Directory of Open Access Journals (Sweden)
Yuan Sun
Full Text Available DNA methylation is a key epigenetic mechanism controlling DNA accessibility and gene expression. Blockade of DNA methylation can significantly affect pain behaviors implicated in neuropathic and inflammatory pain. However, the role of DNA methylation with regard to postoperative pain has not yet been explored. In this study we sought to investigate the role of DNA methylation in modulating incisional pain and identify possible targets under DNA methylation and contributing to incisional pain. DNA methyltranferase (DNMT inhibitor 5-Aza-2'-deoxycytidine significantly reduced incision-induced mechanical allodynia and thermal sensitivity. Aza-2'-deoxycytidine also reduced hindpaw swelling after incision, suggesting an anti-inflammatory effect. Global DNA methylation and DNMT3b expression were increased in skin after incision, but none of DNMT1, DNMT3a or DNMT3b was altered in spinal cord or DRG. The expression of proopiomelanocortin Pomc encoding β-endorphin and Oprm1 encoding the mu-opioid receptor were upregulated peripherally after incision; moreover, Oprm1 expression was further increased under DNMT inhibitor treatment. Finally, local peripheral injection of the opioid receptor antagonist naloxone significantly exacerbated incision-induced mechanical hypersensitivity. These results suggest that DNA methylation is functionally relevant to incisional nociceptive sensitization, and that mu-opioid receptor signaling might be one methylation regulated pathway controlling sensitization after incision.
Methyl 3-(Quinolin-2-ylindolizine-1-carboxylate
Directory of Open Access Journals (Sweden)
Roumaissa Belguedj
2015-12-01
Full Text Available A novel compound, methyl 3-(quinolin-2-ylindolizine-1-carboxylate (2 has been synthesized by cycloaddition reaction of 1-(quinolin-2-ylmethylpyridinium ylide (1 with methyl propiolate in presence of sodium hydride in THF. The structure of this compound was established by IR, 1H-NMR, 13C-NMR and MS data
Adenine N6-methylation in diverse fungi
Seidl, Michael F.
2017-01-01
A DNA modification - methylation of cytosines and adenines - has important roles in diverse processes such as regulation of gene expression and genome stability, yet until recently adenine methylation had been considered to be only a hallmark of prokaryotes. A new study identifies abundant
The nature of Formal Reasoning among Ghanaian Basic School ...
African Journals Online (AJOL)
cce
theories of cognitive development separated the organization of knowledge from practice. ..... Formal operators must be able to distinguish between false and logical arguments. ... Poole, B. (1997) Education for an Information age. Boston: ...
ASLan++ — A Formal Security Specification Language for Distributed Systems
DEFF Research Database (Denmark)
Von Oheimb, David; Mödersheim, Sebastian Alexander
2010-01-01
This paper introduces ASLan++, the AVANTSSAR Specification Language. ASLan++ has been designed for formally specifying dynamically composed security-sensitive web services and service-oriented architectures, their associated security policies, as well as their security properties, at both communi...
Understanding visualization: a formal approach using category theory and semiotics.
Vickers, Paul; Faith, Joe; Rossiter, Nick
2013-06-01
This paper combines the vocabulary of semiotics and category theory to provide a formal analysis of visualization. It shows how familiar processes of visualization fit the semiotic frameworks of both Saussure and Peirce, and extends these structures using the tools of category theory to provide a general framework for understanding visualization in practice, including: Relationships between systems, data collected from those systems, renderings of those data in the form of representations, the reading of those representations to create visualizations, and the use of those visualizations to create knowledge and understanding of the system under inspection. The resulting framework is validated by demonstrating how familiar information visualization concepts (such as literalness, sensitivity, redundancy, ambiguity, generalizability, and chart junk) arise naturally from it and can be defined formally and precisely. This paper generalizes previous work on the formal characterization of visualization by, inter alia, Ziemkiewicz and Kosara and allows us to formally distinguish properties of the visualization process that previous work does not.
PLE in formal education: challenges for openness and control
Kalz, Marco
2015-01-01
This short comment reflects on a critical account of educational tech- nology and makes reference to the chapter by Vieritz et al. about the use of widget bundles for formal learning in higher education.
Uncovering the triple omeron vertex from Wilson line formalism
International Nuclear Information System (INIS)
Chirilli, G. A.; Szymanowski, L.; Wallon, S.
2011-01-01
We compute the triple omeron vertex from the Wilson line formalism, including both planar and nonplanar contributions, and get perfect agreement with the result obtained in the Extended Generalized Logarithmic Approximation based on Reggeon calculus.
Agent-based analysis of organizations : formalization and simulation
Dignum, M.V.; Tick, C.
2007-01-01
Organizational effectiveness depends on many factors, including individual excellence, efficient structures, effective planning and capability to understand and match context requirements. We propose a way to model organizational performance based on a combination of formal models and
Structure, control and regulation of the formal market for medicinal ...
African Journals Online (AJOL)
There are informal and formal markets for medicinal plants' products in Nigeria. ... It is relatively new and underdeveloped. ... physical and facilitating functions while the conduct was described in terms of pricing and promotional strategies.
Contextualising Formal Education for Improved Relevance: A case ...
African Journals Online (AJOL)
Allowing formal education to take place outside of the school. • Necessitating a change in pedagogy to more learner-centred discovery methods. • Allowing ..... Switzerland: International Union for the Conservation of Nature. Barrett, A.
LexGram - a practical categorial grammar formalism -
Koenig, Esther
1995-01-01
We present the LexGram system, an amalgam of (Lambek) categorial grammar and Head Driven Phrase Structure Grammar (HPSG), and show that the grammar formalism it implements is a well-structured and useful tool for actual grammar development.
Formal methods in design and verification of functional specifications
International Nuclear Information System (INIS)
Vaelisuo, H.
1995-01-01
It is claimed that formal methods should be applied already when specifying the functioning of the control/monitoring system, i.e. when planning how to implement the desired operation of the plant. Formal methods are seen as a way to mechanize and thus automate part of the planning. All mathematical methods which can be applied on related problem solving should be considered as formal methods. Because formal methods can only support the designer, not replace him/her, they must be integrated into a design support tool. Such a tool must also aid the designer in getting the correct conception of the plant and its behaviour. The use of a hypothetic design support tool is illustrated to clarify the requirements such a tool should fulfill. (author). 3 refs, 5 figs
The Dante pulse sequence description by product operators formalism
International Nuclear Information System (INIS)
Velloso, Marcia Helena Rodrigues; Villar, Daniel Figueroa
1999-01-01
The objective of this work is to supply a didactic example of the application of the product operators formalism for the description of the DANTE (delays alternating with mutation for tailored excitation) pulse sequence
Thermodynamic and multifractal formalism and the Bowen-series map
International Nuclear Information System (INIS)
Rudolph, O.
1994-07-01
In the theory of quantum chaos one studies the semiclassical behaviour of quantum mechanical systems whose corresponding classical counterparts exhibit chaos. These systems are sometimes considered as model systems in the theory of quantum chaos since they are well understood from a mathematical point of view. In this work we study the multifractal formalism for the geodesic flow on surfaces with constant negative curvature. The multifractal analysis of measures has been developed in order to characterize the scaling behaviour of measures on attractors of classical chaotic dynamical systems globally. In order to relate the multifractal formalism with quantities usually considered in the study of the geodesic flow on Riemann surfaces with constant negative curvature, it is necessary to establish the assertions of the multifractal formalism in a mathematically rigorous way. This is achieved with the help of the thermodynamic formalism for hyperbolic dynamical systems developed by Ruelle, Bowen and others. (orig.)
Dominant partition method. [based on a wave function formalism
Dixon, R. M.; Redish, E. F.
1979-01-01
By use of the L'Huillier, Redish, and Tandy (LRT) wave function formalism, a partially connected method, the dominant partition method (DPM) is developed for obtaining few body reductions of the many body problem in the LRT and Bencze, Redish, and Sloan (BRS) formalisms. The DPM maps the many body problem to a fewer body one by using the criterion that the truncated formalism must be such that consistency with the full Schroedinger equation is preserved. The DPM is based on a class of new forms for the irreducible cluster potential, which is introduced in the LRT formalism. Connectivity is maintained with respect to all partitions containing a given partition, which is referred to as the dominant partition. Degrees of freedom corresponding to the breakup of one or more of the clusters of the dominant partition are treated in a disconnected manner. This approach for simplifying the complicated BRS equations is appropriate for physical problems where a few body reaction mechanism prevails.
CSR-induced emittance growth in achromats: Linear formalism revisited
Energy Technology Data Exchange (ETDEWEB)
Venturini, M.
2015-09-11
We review the R-matrix formalism used to describe Coherent Synchrotron Radiation (CSR)-induced projected emittance growth in electron beam transport lines and establish the connection with a description in terms of the dispersion-invariant function.
Synthesizing Flight Software (FSW) Discrete Controllers from Formal Specifications
National Aeronautics and Space Administration — This project will develop a Domain Specific Language (DSL) approach to interpret requirements and map them to formal specifications and legacy formats; explore and...
Weber, Doug; Jamsek, Damir
1994-01-01
The goal of this task was to investigate how formal methods could be incorporated into a software engineering process for flight-control systems under DO-178B and to demonstrate that process by developing a formal specification for NASA's Guidance and Controls Software (GCS) Experiment. GCS is software to control the descent of a spacecraft onto a planet's surface. The GCS example is simplified from a real example spacecraft, but exhibits the characteristics of realistic spacecraft control software. The formal specification is written in Larch.
Directory of Open Access Journals (Sweden)
Alan Da Silva Esteves Da Silva Esteves
2016-10-01
Full Text Available The assignment of judging in the new Code of Civil Procedure starts with the interactions between classical formalism and democratic formalism. The theories of constitutional hermeneutics, of civil adjectival law and of traditional Positivism are used in order to reaffirm the requirement of motivating the judgment in the higher degree of quality. It is necessary to understand the changes of the standards on the legal interpretation and the act of judging. The concept of jurisdiction in the Constitutional State connects to the constitutional principles of justice and fundamental rights, and approach the formal aspects of materials.
Effects of cytosine methylation on transcription factor binding sites
Medvedeva, Yulia A; Khamis, Abdullah M.; Kulakovskiy, Ivan V; Ba Alawi, Wail; Bhuyan, Md Shariful I; Kawaji, Hideya; Lassmann, Timo; Harbers, Matthias; Forrest, Alistair RR; Bajic, Vladimir B.
2014-01-01
Background: DNA methylation in promoters is closely linked to downstream gene repression. However, whether DNA methylation is a cause or a consequence of gene repression remains an open question. If it is a cause, then DNA methylation may affect
DMPD: TLR ignores methylated RNA? [Dynamic Macrophage Pathway CSML Database
Lifescience Database Archive (English)
Full Text Available 16111629 TLR ignores methylated RNA? Ishii KJ, Akira S. Immunity. 2005 Aug;23(2):11...1-3. (.png) (.svg) (.html) (.csml) Show TLR ignores methylated RNA? PubmedID 16111629 Title TLR ignores methylated
International Nuclear Information System (INIS)
Mustafa, M.F.; Ridwan, N.I.M.; Hatta, F.F.; Yahya, M.Z.A.
2012-01-01
Influences of dimethyl carbonate (DMC) plasticizer on ionic conductivity, dielectric permittivity and electrical modulus formalism of methyl cellulose (MC)-based polymer electrolytes have been studied. The room temperature electrical conductivity as measured by impedance spectroscopy shows that a methyl cellulose film has a conductivity of ∼10 -10 S cm -1 . In this study, other than KOH ionic dopant, DMC plasticizer is also added to the polymer with the aim of enhancing the electrical conductivity of the polymer. The highest room temperature conductivity of the plasticised sample is ∼10 -5 S cm -1 . The plot of log σ versus 10 3 / T for the highest conducting sample obeys Arrhenius rule indicating that the conductivity occurs by thermally activated mechanism. (author)
Modeling spatiotemporal dynamics of DNA methylation
DEFF Research Database (Denmark)
Lövkvist, Cecilia Elisabet
into how epigenetic marks are distributed in the human genome. In the first part of the thesis, we investigate DNA methylation and maintenance of methylation patterns throughout cell division. We argue that collaborative models, those where the methylation of CpG sites depends on the methylation status...... into the game more explicitly in another type of model that speaks out the duality of the two aspects. Using statistical analysis of experimental data, this thesis further explores a link between DNA methylation and nucleosome occupancy. By comparing the patterns on promoters to regions with similar Cp...... division. The patterns of epigentic marks depend on enzymes that ensure their maintenance and introduction. Using theoretical models, this thesis proposes new mechanisms for how enzymes operate to maintain patterns of epigenetic marks. Through analysis of experimental data this work gives new insight...
Protein methylation reactions in intact pea chloroplasts
International Nuclear Information System (INIS)
Niemi, K.J.
1989-01-01
Post-translational protein methylation was investigated in Pisum sativum chloroplasts. Intact pea chloroplasts were incubated with ( 3 H-methyl)-S-adenosylmethionine under various conditions. The chloroplasts were then separated into stromal and thylakoid fractions and analyzed for radioactivity transferred to protein. Light enhanced the magnitude of labeling in both fractions. One thylakoid polypeptide with an apparent molecular mass of 43 kDa was labeled only in the light. Several other thylakoid and stromal proteins were labeled in both light and dark-labeling conditions. Both base-labile methylation, carboxy-methylesters and base-stable groups, N-methylations were found. Further characterization of the methyl-transfer reactions will be presented
Radiation effects on DNA methylation in mice
International Nuclear Information System (INIS)
Komura, J.; Kurishita, A.; Miyamura, Y.; Ono, T.; Tawa, R.; Sakurai, H.
1992-01-01
Effects of ionizing radiation on DNA methylation in liver, brain and spleen were examined by high performance liquid chromatography (HPLC). The total methylated cytosine level in the genome was reduced within 8 hours after 3.8 Gy of irradiation in liver of adult mice. But no appreciable effect was observed in brain and spleen. When mice were irradiated at newborn, liver DNA revealed no change in methylated cytosine level. Even though slight effects of radiation were detected in he methylation of the c-myc and c-fos genes, they were only temporary and no long-term effects were observed. These data suggest that the effect of radiation on DNA methylation in vivo is not prevailing a DNA damage, but rather influenced much through biological parameters. (author)
Methylation analysis of polysaccharides: Technical advice.
Sims, Ian M; Carnachan, Susan M; Bell, Tracey J; Hinkley, Simon F R
2018-05-15
Glycosyl linkage (methylation) analysis is used widely for the structural determination of oligo- and poly-saccharides. The procedure involves derivatisation of the individual component sugars of a polysaccharide to partially methylated alditol acetates which are analysed and quantified by gas chromatography-mass spectrometry. The linkage positions for each component sugar can be determined by correctly identifying the partially methylated alditol acetates. Although the methods are well established, there are many technical aspects to this procedure and both careful attention to detail and considerable experience are required to achieve a successful methylation analysis and to correctly interpret the data generated. The aim of this article is to provide the technical details and critical procedural steps necessary for a successful methylation analysis and to assist researchers (a) with interpreting data correctly and (b) in providing the comprehensive data required for reviewers to fully assess the work. Copyright © 2018 Elsevier Ltd. All rights reserved.
Directory of Open Access Journals (Sweden)
Dimos Gaidatzis
2014-02-01
Full Text Available For the most part metazoan genomes are highly methylated and harbor only small regions with low or absent methylation. In contrast, partially methylated domains (PMDs, recently discovered in a variety of cell lines and tissues, do not fit this paradigm as they show partial methylation for large portions (20%-40% of the genome. While in PMDs methylation levels are reduced on average, we found that at single CpG resolution, they show extensive variability along the genome outside of CpG islands and DNase I hypersensitive sites (DHS. Methylation levels range from 0% to 100% in a roughly uniform fashion with only little similarity between neighboring CpGs. A comparison of various PMD-containing methylomes showed that these seemingly disordered states of methylation are strongly conserved across cell types for virtually every PMD. Comparative sequence analysis suggests that DNA sequence is a major determinant of these methylation states. This is further substantiated by a purely sequence based model which can predict 31% (R(2 of the variation in methylation. The model revealed CpG density as the main driving feature promoting methylation, opposite to what has been shown for CpG islands, followed by various dinucleotides immediately flanking the CpG and a minor contribution from sequence preferences reflecting nucleosome positioning. Taken together we provide a reinterpretation for the nucleotide-specific methylation levels observed in PMDs, demonstrate their conservation across tissues and suggest that they are mainly determined by specific DNA sequence features.
Dynamics of trade between the formal sector and informal traders
Cyril Nhlanhla Ngiba; David Dickinson; Louise Whittaker; Claire Beswick
2011-01-01
The informal sector in South Africa is a significant, but not well understood phenomenon. One important question relates to the nature of the relationship between the formal and informal sector. This article uses Porter’s five forces model to interrogate the linkages between informal fruit and vegetable traders in the Natalspruit Market (Ekurhuleni) and their formal suppliers, primarily the Johannesburg Fresh Produce Market. While the threat of new products is low, the street traders’ positio...
Fedosov’s formal symplectic groupoids and contravariant connections
Karabegov, Alexander V.
2006-10-01
Using Fedosov's approach we give a geometric construction of a formal symplectic groupoid over any Poisson manifold endowed with a torsion-free Poisson contravariant connection. In the case of Kähler-Poisson manifolds this construction provides, in particular, the formal symplectic groupoids with separation of variables. We show that the dual of a semisimple Lie algebra does not admit torsion-free Poisson contravariant connections.
PRODUCTION SYSTEM MODELING AND SIMULATION USING DEVS FORMALISM
Amaya Hurtado, Darío; Castillo Estepa, Ricardo Andrés; Avilés Montaño, Óscar Fernando; Ramos Sandoval, Olga Lucía
2014-01-01
This article presents the Discrete Event System Specification (DEVS) formalism, in their atomic and coupled configurations; it is used for discrete event systems modeling and simulation. Initially this work describes the analysis of discrete event systems concepts and its applicability. Then a comprehensive description of the DEVS formalism structure is presented, in order to model and simulate an industrial process, taking into account changes in parameters such as process service time, each...
A Formal Semantics for Concept Understanding relying on Description Logics
DEFF Research Database (Denmark)
Badie, Farshad
2017-01-01
logical assumptions whose discovery may lead us to a better understanding of ‘concept understanding’. The Structure of Observed Learning Outcomes (SOLO) model as an appropriate model of increasing complexity of humans’ understanding has supported the formal analysis.......In this research, Description Logics (DLs) will be employed for logical description, logical characterisation, logical modelling and ontological description of concept understanding in terminological systems. It’s strongly believed that using a formal descriptive logic could support us in revealing...
Software Components and Formal Methods from a Computational Viewpoint
Lambertz, Christian
2012-01-01
Software components and the methodology of component-based development offer a promising approach to master the design complexity of huge software products because they separate the concerns of software architecture from individual component behavior and allow for reusability of components. In combination with formal methods, the specification of a formal component model of the later software product or system allows for establishing and verifying important system properties in an automatic a...
Formal and Informal Normative Beliefs Regarding Purchasing and Using Condoms
樋口, 匡貴; 中村, 菜々子
2009-01-01
Properly using condoms is one of the most effective types of protection against HIV. To clarify the contents of normative beliefs regarding purchasing and using condoms, 390 undergraduate student volunteers were surveyed. The exploratory and confirmatory factor analyses revealed that both males and females held two types of normative beliefs, namely formal normative beliefs and informal normative beliefs, regarding purchasing and using condoms. Formal normative beliefs were concerned with the...
Superfield Lax formalism of supersymmetric sigma model on symmetric spaces
International Nuclear Information System (INIS)
Saleem, U.; Hassan, M.
2006-01-01
We present a superfield Lax formalism of the superspace sigma model based on the target space G/H and show that a one-parameter family of flat superfield connections exists if the target space G/H is a symmetric space. The formalism has been related to the existence of an infinite family of local and non-local superfield conserved quantities. A few examples have been given to illustrate the results. (orig.)
General relativistic variation formalism for a probe particle with momenta
Energy Technology Data Exchange (ETDEWEB)
Minkevich, A V; Sokol' skii, A A [Belorusskij Gosudarstvennyj Univ., Minsk
1975-01-01
On the basis of a model of an oriental particle a variational formalism was developed for a rotating test particle having momenta and moving in inhomogeneous space-time: the Lagrange equations for translational and rotational motion were obtained, and a metric pulse energy tensor was found. The formalism applies to a charged rotating particle with an electrical and a magnetic moment and a rotating particle in space with curvature and torsion.
FORMED: Bringing Formal Methods to the Engineering Desktop
2016-02-01
FORMED: BRINGING FORMAL METHODS TO THE ENGINEERING DESKTOP BAE SYSTEMS FEBRUARY 2016 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE...This report is published in the interest of scientific and technical information exchange, and its publication does not constitute the Government’s...BRINGING FORMAL METHODS TO THE ENGINEERING DESKTOP 5a. CONTRACT NUMBER FA8750-14-C-0024 5b. GRANT NUMBER N/A 5c. PROGRAM ELEMENT NUMBER 63781D
A Formalization of Kant's Second Formulation of the Categorical Imperative
Lindner, Felix; Bentzen, Martin Mose
2018-01-01
We present a formalization and computational implementation of the second formulation of Kant's categorical imperative. This ethical principle requires an agent to never treat someone merely as a means but always also as an end. Here we interpret this principle in terms of how persons are causally affected by actions. We introduce Kantian causal agency models in which moral patients, actions, goals, and causal influence are represented, and we show how to formalize several readings of Kant's ...
Skinner-Rusk unified formalism for higher-order systems
Prieto-Martínez, Pedro Daniel; Román-Roy, Narciso
2012-07-01
The Lagrangian-Hamiltonian unified formalism of R. Skinner and R. Rusk was originally stated for autonomous dynamical systems in classical mechanics. It has been generalized for non-autonomous first-order mechanical systems, first-order and higher-order field theories, and higher-order autonomous systems. In this work we present a generalization of this formalism for higher-order non-autonomous mechanical systems.
A Formal Semantics for Concept Understanding relying on Description Logics
DEFF Research Database (Denmark)
Badie, Farshad
2017-01-01
In this research, Description Logics (DLs) will be employed for logical description, logical characterisation, logical modelling and ontological description of concept understanding in terminological systems. It’s strongly believed that using a formal descriptive logic could support us in reveali...... logical assumptions whose discovery may lead us to a better understanding of ‘concept understanding’. The Structure of Observed Learning Outcomes (SOLO) model as an appropriate model of increasing complexity of humans’ understanding has supported the formal analysis....
Informal Versus Formal Search : Which Yields a Better Pay?
Semih Tumen
2015-01-01
Estimates on the effect of job contact method – i.e., informal versus formal search – on wage offers vary considerably across studies, with some of them finding a positive correlation between getting help from informal connections and obtaining high-paying jobs, while others finding a negative one. In this paper, I theoretically investigate the sources of discrepancies in these empirical results. Using a formal job search framework, I derive an equilibrium wage distribution which reveals that...
Procedural Formalism and Social Networks in the Housing Market
Bonleu, Antoine
2014-01-01
Why do some OECD countries have high levels of procedural formalism (PF) in the housing market? We provide an explanation based upon complementarities between the strength of social networks and the stringency of procedural formalism. The interest of social networks is that conflict resolution is independent of the law. When local people belong to social networks whereas foreigners do not, PF may facilitate housing search for locals at the expense of foreigners. To illustrate this mechanism w...
Improved pion pion scattering amplitude from dispersion relation formalism
International Nuclear Information System (INIS)
Cavalcante, I.P.; Coutinho, Y.A.; Borges, J. Sa
2005-01-01
Pion-pion scattering amplitude is obtained from Chiral Perturbation Theory at one- and two-loop approximations. Dispersion relation formalism provides a more economic method, which was proved to reproduce the analytical structure of that amplitude at both approximation levels. This work extends the use of the formalism in order to compute further unitarity corrections to partial waves, including the D-wave amplitude. (author)
Criteria of benchmark selection for efficient flexible multibody system formalisms
Directory of Open Access Journals (Sweden)
Valášek M.
2007-10-01
Full Text Available The paper deals with the selection process of benchmarks for testing and comparing efficient flexible multibody formalisms. The existing benchmarks are briefly summarized. The purposes for benchmark selection are investigated. The result of this analysis is the formulation of the criteria of benchmark selection for flexible multibody formalisms. Based on them the initial set of suitable benchmarks is described. Besides that the evaluation measures are revised and extended.
On Formalization of the Concept of Value Proposition
Marek Winkler; Vladimír Dosoudil
2011-01-01
This paper presents an original description and a semi-formal definition of the concept of a value proposition, which has been so far used in service science rather intuitively. Our approach is based on utility functions and conceptual modelling techniques. The proposed semi-formalization can be exploited to describe services from the point of view of their (potential) utility for their clients. This description can be used especially to organize a service portfolio in an enterprise in a bett...
Type I supergravity effective action from pure spinor formalism
International Nuclear Information System (INIS)
Alencar, Geova
2009-01-01
Using the pure spinor formalism, we compute the tree-level correlation functions for three strings, one closed and two open, in N = 1 D = 10 superspace. Expanding the superfields in components, the respective terms of the effective action for the type I supergravity are obtained. All terms found agree with the effective action known in the literature. This result gives one more consistency test for the pure spinor formalism.
General relativistic variation formalism for a probe particle with momenta
International Nuclear Information System (INIS)
Minkevich, A.V.; Sokol'skij, A.A.
1975-01-01
On the basis of a model of an oriental particle a variational formalism was developed for a rotating test particle having momenta and moving in inhomogeneous space-time: the Lagrange equations for translational and rotational motion were obtained, and a metric pulse energy tensor was found. The formalism applies to a charged rotating particle with an electrical and a magnetic moment and a rotating particle in space with curvature and torsion. (author)
Peraza-Echeverria, S; Herrera-Valencia, V A.; Kay, A -J.
2001-07-01
The extent of DNA methylation polymorphisms was evaluated in micropropagated banana (Musa AAA cv. 'Grand Naine') derived from either the vegetative apex of the sucker or the floral apex of the male inflorescence using the methylation-sensitive amplification polymorphism (MSAP) technique. In all, 465 fragments, each representing a recognition site cleaved by either or both of the isoschizomers were amplified using eight combinations of primers. A total of 107 sites (23%) were found to be methylated at cytosine in the genome of micropropagated banana plants. In plants micropropagated from the male inflorescence explant 14 (3%) DNA methylation events were polymorphic, while plants micropropagated from the sucker explant produced 8 (1.7%) polymorphisms. No DNA methylation polymorphisms were detected in conventionally propagated banana plants. These results demonstrated the usefulness of MSAP to detect DNA methylation events in micropropagated banana plants and indicate that DNA methylation polymorphisms are associated with micropropagation.
The origin and fate of 4-methyl steroid hydrocarbons. I. Diagenesis of 4-methyl sterenes
Wolff, George A.; Lamb, Neil A.; Maxwell, James R.
1986-03-01
Treatment of 4-methylcholest-4-ene under mild acid conditions at low temperatures gives chemical evidence for certain features seen in the distributions of sedimentary 4-methyl steroid hydrocarbons, and further indicates that many low temperature diagenetic reactions of steroids are explicable in terms of acid catalysed rearrangements. Specifically, the results provide: (i) Indirect evidence that the 4-ene skeleton is a key intermediate in the dehydration of 4-methyl stanols in sediments. (ii) An explanation for the distribution of 4-methyl sterenes and A-nor sterenes in the lacustrine Messel shale (Eocene). (iii) An explanation for the presence of 4β-methyl steranes in relatively immature sedimentary rocks, despite the precursor stanols having the 4α-methyl configuration. With increasing maturity in the Paris Basin shales (Lower Toarcian), the less stable 4β-methyl steranes decrease gradually in abundance relative to their 4α-methyl counterparts, at a rate fairly similar to the change in pristane stereochemistry.
Adolescent thinking ála Piaget: The formal stage.
Dulit, E
1972-12-01
Two of the formal-stage experiments of Piaget and Inhelder, selected largely for their closeness to the concepts defining the stage, were replicated with groups of average and gifted adolescents. This report describes the relevant Piagetian concepts (formal stage, concrete stage) in context, gives the methods and findings of this study, and concludes with a section discussing implications and making some reformulations which generally support but significantly qualify some of the central themes of the Piaget-Inhelder work. Fully developed formal-stage thinking emerges as far from commonplace among normal or average adolescents (by marked contrast with the impression created by the Piaget-Inhelder text, which chooses to report no middle or older adolescents who function at less than fully formal levels). In this respect, the formal stage differs appreciably from the earlier Piagetian stages, and early adolescence emerges as the age for which a "single path" model of cognitive development becomes seriously inadequate and a more complex model becomes essential. Formal-stage thinking seems best conceptualized, like most other aspects of psychological maturity, as a potentiality only partially attained by most and fully attained only by some.
Robot-assisted laparoscopic skills development: formal versus informal training.
Benson, Aaron D; Kramer, Brandan A; Boehler, Margaret; Schwind, Cathy J; Schwartz, Bradley F
2010-08-01
The learning curve for robotic surgery is not completely defined, and ideal training components have not yet been identified. We attempted to determine whether skill development would be accelerated with formal, organized instruction in robotic surgical techniques versus informal practice alone. Forty-three medical students naive to robotic surgery were randomized into two groups and tested on three tasks using the robotic platform. Between the testing sessions, the students were given equally timed practice sessions. The formal training group participated in an organized, formal training session with instruction from an attending robotic surgeon, whereas the informal training group participated in an equally timed unstructured practice session with the robot. The results were compared based on technical score and time to completion of each task. There was no difference between groups in prepractice testing for any task. In postpractice testing, there was no difference between groups for the ring transfer tasks. However, for the suture placement and knot-tying task, the technical score of the formal training group was significantly better than that of the informal training group (p formal training may not be necessary for basic skills, formal instruction for more advanced skills, such as suture placement and knot tying, is important in developing skills needed for effective robotic surgery. These findings may be important in formulating potential skills labs or training courses for robotic surgery.
Orality and literacy, formality and informality in email communication
Directory of Open Access Journals (Sweden)
Carmen Pérez Sabater
2008-04-01
Full Text Available Approaches to the linguistic characteristics of computer-mediated communication (CMC have highlighted the frequent oral traits involved in electronic mail along with features of written language. But email is today a new communication exchange medium in social, professional and academic settings, frequently used as a substitute for the traditional formal letter. The oral characterizations and linguistic formality involved in this use of emails are still in need of research. This paper explores the formal and informal features in emails based on a corpus of messages exchanged by academic institutions, and studies the similarities and differences on the basis of their mode of communication (one-to-one or one-to-many and the sender’s mother tongue (native or nonnative. The language samples collected were systematically analyzed for formality of greetings and farewells, use of contractions, politeness indicators and non-standard linguistic features. The findings provide new insights into traits of orality and formality in email communication and demonstrate the emergence of a new style in writing for even the most important, confidential and formal purposes which seems to be forming a new sub-genre of letter-writing.
Proceedings of the First NASA Formal Methods Symposium
Denney, Ewen (Editor); Giannakopoulou, Dimitra (Editor); Pasareanu, Corina S. (Editor)
2009-01-01
Topics covered include: Model Checking - My 27-Year Quest to Overcome the State Explosion Problem; Applying Formal Methods to NASA Projects: Transition from Research to Practice; TLA+: Whence, Wherefore, and Whither; Formal Methods Applications in Air Transportation; Theorem Proving in Intel Hardware Design; Building a Formal Model of a Human-Interactive System: Insights into the Integration of Formal Methods and Human Factors Engineering; Model Checking for Autonomic Systems Specified with ASSL; A Game-Theoretic Approach to Branching Time Abstract-Check-Refine Process; Software Model Checking Without Source Code; Generalized Abstract Symbolic Summaries; A Comparative Study of Randomized Constraint Solvers for Random-Symbolic Testing; Component-Oriented Behavior Extraction for Autonomic System Design; Automated Verification of Design Patterns with LePUS3; A Module Language for Typing by Contracts; From Goal-Oriented Requirements to Event-B Specifications; Introduction of Virtualization Technology to Multi-Process Model Checking; Comparing Techniques for Certified Static Analysis; Towards a Framework for Generating Tests to Satisfy Complex Code Coverage in Java Pathfinder; jFuzz: A Concolic Whitebox Fuzzer for Java; Machine-Checkable Timed CSP; Stochastic Formal Correctness of Numerical Algorithms; Deductive Verification of Cryptographic Software; Coloured Petri Net Refinement Specification and Correctness Proof with Coq; Modeling Guidelines for Code Generation in the Railway Signaling Context; Tactical Synthesis Of Efficient Global Search Algorithms; Towards Co-Engineering Communicating Autonomous Cyber-Physical Systems; and Formal Methods for Automated Diagnosis of Autosub 6000.
Kors, Ninja; Mak, Peter
2006-01-01
The pilot project that will be described in this report was all about the animateur. What are his skills and attitudes? What are the pedagogical interventions that he uses in a workshop or an event? What are the main issues that arise when we try to include such a naturally non-formal and informal
Matching biomedical ontologies based on formal concept analysis.
Zhao, Mengyi; Zhang, Songmao; Li, Weizhuo; Chen, Guowei
2018-03-19
The goal of ontology matching is to identify correspondences between entities from different yet overlapping ontologies so as to facilitate semantic integration, reuse and interoperability. As a well developed mathematical model for analyzing individuals and structuring concepts, Formal Concept Analysis (FCA) has been applied to ontology matching (OM) tasks since the beginning of OM research, whereas ontological knowledge exploited in FCA-based methods is limited. This motivates the study in this paper, i.e., to empower FCA with as much as ontological knowledge as possible for identifying mappings across ontologies. We propose a method based on Formal Concept Analysis to identify and validate mappings across ontologies, including one-to-one mappings, complex mappings and correspondences between object properties. Our method, called FCA-Map, incrementally generates a total of five types of formal contexts and extracts mappings from the lattices derived. First, the token-based formal context describes how class names, labels and synonyms share lexical tokens, leading to lexical mappings (anchors) across ontologies. Second, the relation-based formal context describes how classes are in taxonomic, partonomic and disjoint relationships with the anchors, leading to positive and negative structural evidence for validating the lexical matching. Third, the positive relation-based context can be used to discover structural mappings. Afterwards, the property-based formal context describes how object properties are used in axioms to connect anchor classes across ontologies, leading to property mappings. Last, the restriction-based formal context describes co-occurrence of classes across ontologies in anonymous ancestors of anchors, from which extended structural mappings and complex mappings can be identified. Evaluation on the Anatomy, the Large Biomedical Ontologies, and the Disease and Phenotype track of the 2016 Ontology Alignment Evaluation Initiative campaign
NON-FORMAL EDUCATION WITHIN THE FUNCTION OF RESPONSIBLE PARENTING
Directory of Open Access Journals (Sweden)
Dragana Bogavac
2017-06-01
Full Text Available The aim of this survey was to discover to what degree parental non-formal education is present within the function of responsible parenting. The questionnaire research method was used in the survey. For the purpose of this research a questionnaire of 13 questions was constructed relating to the forms of non-formal education, and another questionnaire of 10 questions relating to the parents’ expectations of non-formal education. The sample included 198 parents. Examination of the scores concerning the presence of certain forms of parental non-formal education realized in cooperation with the school leads to the conclusion that the parents possess a positive attitude towards non-formal education. The analysis showed that the parents’ expectations were not on a satisfactory level. According to the results, the fathers displayed a greater interest towards non-formal education (7.72±1.35 than the mothers (6.93±1.85, (p<0.05. Unemployed parents had a greater score (7.85±1.30 than the employed parents (7.22±1.71, (p<0.05. A difference in the acceptance of non-formal education in accordance with the level of formal education was also noticeable (p<0.001. Respondents with a high school degree displayed the highest level of acceptance (7.97±0.78, while the lowest interest was seen in respondents with an associate degree (6.41±2.29. Univariate linear regression analysis showed that statistically important predictors were: gender (OR: -0.23 (-1.24 – -0.33, p< 0.001, work status (OR: -0.14 (-1.24 – -0.01, < 0.05 and the level of formal education (OR: -0.33 (-0.81 – -0.34, p< 0.001. The final results lead to the conclusion that parental non-formal education supports the concept of lifelong education.
Barriers to formal emergency obstetric care services' utilization.
Essendi, Hildah; Mills, Samuel; Fotso, Jean-Christophe
2011-06-01
Access to appropriate health care including skilled birth attendance at delivery and timely referrals to emergency obstetric care services can greatly reduce maternal deaths and disabilities, yet women in sub-Saharan Africa continue to face limited access to skilled delivery services. This study relies on qualitative data collected from residents of two slums in Nairobi, Kenya in 2006 to investigate views surrounding barriers to the uptake of formal obstetric services. Data indicate that slum dwellers prefer formal to informal obstetric services. However, their efforts to utilize formal emergency obstetric care services are constrained by various factors including ineffective health decision making at the family level, inadequate transport facilities to formal care facilities and insecurity at night, high cost of health services, and inhospitable formal service providers and poorly equipped health facilities in the slums. As a result, a majority of slum dwellers opt for delivery services offered by traditional birth attendants (TBAs) who lack essential skills and equipment, thereby increasing the risk of death and disability. Based on these findings, we maintain that urban poor women face barriers to access of formal obstetric services at family, community, and health facility levels, and efforts to reduce maternal morbidity and mortality among the urban poor must tackle the barriers, which operate at these different levels to hinder women's access to formal obstetric care services. We recommend continuous community education on symptoms of complications related to pregnancy and timely referral. A focus on training of health personnel on "public relations" could also restore confidence in the health-care system with this populace. Further, we recommend improving the health facilities in the slums, improving the services provided by TBAs through capacity building as well as involving TBAs in referral processes to make access to services timely. Measures can also be
Does formal research training lead to academic success in otolaryngology?
Bobian, Michael R; Shah, Noor; Svider, Peter F; Hong, Robert S; Shkoukani, Mahdi A; Folbe, Adam J; Eloy, Jean Anderson
2017-01-01
To evaluate whether formalized research training is associated with higher researcher productivity, academic rank, and acquisition of National Institutes of Health (NIH) grants within academic otolaryngology departments. Each of the 100 civilian otolaryngology program's departmental websites were analyzed to obtain a comprehensive list of faculty members credentials and characteristics, including academic rank, completion of a clinical fellowship, completion of a formal research fellowship, and attainment of a doctorate in philosophy (PhD) degree. We also recorded measures of scholarly impact and successful acquisition of NIH funding. A total of 1,495 academic physicians were included in our study. Of these, 14.1% had formal research training. Bivariate associations showed that formal research training was associated with a greater h-index, increased probability of acquiring NIH funding, and higher academic rank. Using a linear regression model, we found that otolaryngologists possessing a PhD had an associated h-index of 1.8 points higher, and those who completed a formal research fellowship had an h-index of 1.6 points higher. A PhD degree or completion of a research fellowship was not associated with a higher academic rank; however, a higher h-index and previous acquisition of an NIH grant were associated with a higher academic rank. The attainment of NIH funding was three times more likely for those with a formal research fellowship and 8.6 times more likely for otolaryngologists with a PhD degree. Formalized research training is associated with academic success in otolaryngology. Such dedicated research training accompanies greater scholarly impact, acquisition of NIH funding, and a higher academic rank. NA Laryngoscope, 127:E15-E21, 2017. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.
Global DNA methylation analysis using methyl-sensitive amplification polymorphism (MSAP).
Yaish, Mahmoud W; Peng, Mingsheng; Rothstein, Steven J
2014-01-01
DNA methylation is a crucial epigenetic process which helps control gene transcription activity in eukaryotes. Information regarding the methylation status of a regulatory sequence of a particular gene provides important knowledge of this transcriptional control. DNA methylation can be detected using several methods, including sodium bisulfite sequencing and restriction digestion using methylation-sensitive endonucleases. Methyl-Sensitive Amplification Polymorphism (MSAP) is a technique used to study the global DNA methylation status of an organism and hence to distinguish between two individuals based on the DNA methylation status determined by the differential digestion pattern. Therefore, this technique is a useful method for DNA methylation mapping and positional cloning of differentially methylated genes. In this technique, genomic DNA is first digested with a methylation-sensitive restriction enzyme such as HpaII, and then the DNA fragments are ligated to adaptors in order to facilitate their amplification. Digestion using a methylation-insensitive isoschizomer of HpaII, MspI is used in a parallel digestion reaction as a loading control in the experiment. Subsequently, these fragments are selectively amplified by fluorescently labeled primers. PCR products from different individuals are compared, and once an interesting polymorphic locus is recognized, the desired DNA fragment can be isolated from a denaturing polyacrylamide gel, sequenced and identified based on DNA sequence similarity to other sequences available in the database. We will use analysis of met1, ddm1, and atmbd9 mutants and wild-type plants treated with a cytidine analogue, 5-azaC, or zebularine to demonstrate how to assess the genetic modulation of DNA methylation in Arabidopsis. It should be noted that despite the fact that MSAP is a reliable technique used to fish for polymorphic methylated loci, its power is limited to the restriction recognition sites of the enzymes used in the genomic
DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors
International Nuclear Information System (INIS)
Amatruda, James F; Frazier, A Lindsay; Poynter, Jenny N; Ross, Julie A; Christensen, Brock; Fustino, Nicholas J; Chen, Kenneth S; Hooten, Anthony J; Nelson, Heather; Kuriger, Jacquelyn K; Rakheja, Dinesh
2013-01-01
Aberrant DNA methylation is a prominent feature of many cancers, and may be especially relevant in germ cell tumors (GCTs) due to the extensive epigenetic reprogramming that occurs in the germ line during normal development. We used the Illumina GoldenGate Cancer Methylation Panel to compare DNA methylation in the three main histologic subtypes of pediatric GCTs (germinoma, teratoma and yolk sac tumor (YST); N = 51) and used recursively partitioned mixture models (RPMM) to test associations between methylation pattern and tumor and demographic characteristics. We identified genes and pathways that were differentially methylated using generalized linear models and Ingenuity Pathway Analysis. We also measured global DNA methylation at LINE1 elements and evaluated methylation at selected imprinted loci using pyrosequencing. Methylation patterns differed by tumor histology, with 18/19 YSTs forming a distinct methylation class. Four pathways showed significant enrichment for YSTs, including a human embryonic stem cell pluripotency pathway. We identified 190 CpG loci with significant methylation differences in mature and immature teratomas (q < 0.05), including a number of CpGs in stem cell and pluripotency-related pathways. Both YST and germinoma showed significantly lower methylation at LINE1 elements compared with normal adjacent tissue while there was no difference between teratoma (mature and immature) and normal tissue. DNA methylation at imprinted loci differed significantly by tumor histology and location. Understanding methylation patterns may identify the developmental stage at which the GCT arose and the at-risk period when environmental exposures could be most harmful. Further, identification of relevant genetic pathways could lead to the development of new targets for therapy
Dynamics of trade between the formal sector and informal traders
Directory of Open Access Journals (Sweden)
Cyril Nhlanhla Ngiba
2011-04-01
Full Text Available The informal sector in South Africa is a significant, but not well understood phenomenon. One important question relates to the nature of the relationship between the formal and informal sector. This article uses Porter’s five forces model to interrogate the linkages between informal fruit and vegetable traders in the Natalspruit Market (Ekurhuleni and their formal suppliers, primarily the Johannesburg Fresh Produce Market. While the threat of new products is low, the street traders’ position is weakened by the threat of new entrants, consumer bargaining power and lack of cooperation among street traders. In relation to supplier power, we conclude that while this varies according to a number of factors, the formal sector is dominant over informal fruit and vegetable sellers in this market. This finding rests primarily on the observation that, because of their fragmentation, the informal traders’ collective buying power is not being used in the same way as large formal retailers of fruit and vegetables to obtain better terms of trade with the formal economy supplier.
Longitudinal Associations Between Formal Volunteering and Cognitive Functioning.
Proulx, Christine M; Curl, Angela L; Ermer, Ashley E
2018-03-02
The present study examines the association between formal volunteering and cognitive functioning over time. We also examine the moderating roles of race, sex, education, and time. Using 11,100 participants aged 51 years and older and nine waves of data from the Health and Retirement Survey, we simultaneously modeled the longitudinal associations between engaging in formal volunteering and changes in cognitive functioning using multilevel models. Formal volunteering was associated with higher levels of cognitive functioning over time, especially with aspects of cognitive functioning related to working memory and processing. This association was stronger for women than it was for men, and for those with below average levels of education. The positive association between formal volunteering and cognitive functioning weakened over time when cognitive functioning was conceptualized as memory, but strengthened over time when conceptualized as working memory and processing. Volunteering is a productive activity that is beneficial not just to society, but to volunteers' levels of cognitive functioning in older age. For women and those with lower levels of education, formal volunteering appears particularly beneficial to working memory and processing. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Interacting hadron resonance gas model in the K -matrix formalism
Dash, Ashutosh; Samanta, Subhasis; Mohanty, Bedangadas
2018-05-01
An extension of hadron resonance gas (HRG) model is constructed to include interactions using relativistic virial expansion of partition function. The noninteracting part of the expansion contains all the stable baryons and mesons and the interacting part contains all the higher mass resonances which decay into two stable hadrons. The virial coefficients are related to the phase shifts which are calculated using K -matrix formalism in the present work. We have calculated various thermodynamics quantities like pressure, energy density, and entropy density of the system. A comparison of thermodynamic quantities with noninteracting HRG model, calculated using the same number of hadrons, shows that the results of the above formalism are larger. A good agreement between equation of state calculated in K -matrix formalism and lattice QCD simulations is observed. Specifically, the lattice QCD calculated interaction measure is well described in our formalism. We have also calculated second-order fluctuations and correlations of conserved charges in K -matrix formalism. We observe a good agreement of second-order fluctuations and baryon-strangeness correlation with lattice data below the crossover temperature.
Applications of a formal approach to decipher discrete genetic networks.
Corblin, Fabien; Fanchon, Eric; Trilling, Laurent
2010-07-20
A growing demand for tools to assist the building and analysis of biological networks exists in systems biology. We argue that the use of a formal approach is relevant and applicable to address questions raised by biologists about such networks. The behaviour of these systems being complex, it is essential to exploit efficiently every bit of experimental information. In our approach, both the evolution rules and the partial knowledge about the structure and the behaviour of the network are formalized using a common constraint-based language. In this article our formal and declarative approach is applied to three biological applications. The software environment that we developed allows to specifically address each application through a new class of biologically relevant queries. We show that we can describe easily and in a formal manner the partial knowledge about a genetic network. Moreover we show that this environment, based on a constraint algorithmic approach, offers a wide variety of functionalities, going beyond simple simulations, such as proof of consistency, model revision, prediction of properties, search for minimal models relatively to specified criteria. The formal approach proposed here deeply changes the way to proceed in the exploration of genetic and biochemical networks, first by avoiding the usual trial-and-error procedure, and second by placing the emphasis on sets of solutions, rather than a single solution arbitrarily chosen among many others. Last, the constraint approach promotes an integration of model and experimental data in a single framework.
Evaluating genome-wide DNA methylation changes in mice by Methylation Specific Digital Karyotyping
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Maruoka Shuichiro
2008-12-01
Full Text Available Abstract Background The study of genome-wide DNA methylation changes has become more accessible with the development of various array-based technologies though when studying species other than human the choice of applications are limited and not always within reach. In this study, we adapted and tested the applicability of Methylation Specific Digital Karyotyping (MSDK, a non-array based method, for the prospective analysis of epigenetic changes after perinatal nutritional modifications in a mouse model of allergic airway disease. MSDK is a sequenced based method that allows a comprehensive and unbiased methylation profiling. The method generates 21 base pairs long sequence tags derived from specific locations in the genome. The resulting tag frequencies determine in a quantitative manner the methylation level of the corresponding loci. Results Genomic DNA from whole lung was isolated and subjected to MSDK analysis using the methylation-sensitive enzyme Not I as the mapping enzyme and Nla III as the fragmenting enzyme. In a pair wise comparison of the generated mouse MSDK libraries we identified 158 loci that are significantly differentially methylated (P-value = 0.05 after perinatal dietary changes in our mouse model. Quantitative methylation specific PCR and sequence analysis of bisulfate modified genomic DNA confirmed changes in methylation at specific loci. Differences in genomic MSDK tag counts for a selected set of genes, correlated well with changes in transcription levels as measured by real-time PCR. Furthermore serial analysis of gene expression profiling demonstrated a dramatic difference in expressed transcripts in mice exposed to perinatal nutritional changes. Conclusion The genome-wide methylation survey applied in this study allowed for an unbiased methylation profiling revealing subtle changes in DNA methylation in mice maternally exposed to dietary changes in methyl-donor content. The MSDK method is applicable for mouse models
Theory of long-lived nuclear spin states in methyl groups and quantum-rotor induced polarisation.
Dumez, Jean-Nicolas; Håkansson, Pär; Mamone, Salvatore; Meier, Benno; Stevanato, Gabriele; Hill-Cousins, Joseph T; Roy, Soumya Singha; Brown, Richard C D; Pileio, Giuseppe; Levitt, Malcolm H
2015-01-28
Long-lived nuclear spin states have a relaxation time much longer than the longitudinal relaxation time T1. Long-lived states extend significantly the time scales that may be probed with magnetic resonance, with possible applications to transport and binding studies, and to hyperpolarised imaging. Rapidly rotating methyl groups in solution may support a long-lived state, consisting of a population imbalance between states of different spin exchange symmetries. Here, we expand the formalism for describing the behaviour of long-lived nuclear spin states in methyl groups, with special attention to the hyperpolarisation effects observed in (13)CH3 groups upon rapidly converting a material with low-barrier methyl rotation from the cryogenic solid state to a room-temperature solution [M. Icker and S. Berger, J. Magn. Reson. 219, 1 (2012)]. We analyse the relaxation properties of methyl long-lived states using semi-classical relaxation theory. Numerical simulations are supplemented with a spherical-tensor analysis, which captures the essential properties of methyl long-lived states.
Theory of long-lived nuclear spin states in methyl groups and quantum-rotor induced polarisation
International Nuclear Information System (INIS)
Dumez, Jean-Nicolas; Håkansson, Pär; Mamone, Salvatore; Meier, Benno; Stevanato, Gabriele; Hill-Cousins, Joseph T.; Roy, Soumya Singha; Brown, Richard C. D.; Pileio, Giuseppe; Levitt, Malcolm H.
2015-01-01
Long-lived nuclear spin states have a relaxation time much longer than the longitudinal relaxation time T 1 . Long-lived states extend significantly the time scales that may be probed with magnetic resonance, with possible applications to transport and binding studies, and to hyperpolarised imaging. Rapidly rotating methyl groups in solution may support a long-lived state, consisting of a population imbalance between states of different spin exchange symmetries. Here, we expand the formalism for describing the behaviour of long-lived nuclear spin states in methyl groups, with special attention to the hyperpolarisation effects observed in 13 CH 3 groups upon rapidly converting a material with low-barrier methyl rotation from the cryogenic solid state to a room-temperature solution [M. Icker and S. Berger, J. Magn. Reson. 219, 1 (2012)]. We analyse the relaxation properties of methyl long-lived states using semi-classical relaxation theory. Numerical simulations are supplemented with a spherical-tensor analysis, which captures the essential properties of methyl long-lived states
Homogalacturonan methyl-esterification and plant development.
Wolf, Sebastian; Mouille, Grégory; Pelloux, Jérome
2009-09-01
The ability of a plant cell to expand is largely defined by the physical constraints imposed by its cell wall. Accordingly, cell wall properties have to be regulated during development. The pectic polysaccharide homogalacturonan is a major component of the plant primary walls. Biosynthesis and in muro modification of homogalacturonan have recently emerged as key determinants of plant development, controlling cell adhesion, organ development, and phyllotactic patterning. This review will focus on recent findings regarding impact of homogalacturonan content and methyl-esterification status of this polymer on plant life. De-methyl-esterification of homogalacturonan occurs through the action of the ubiquitous enzyme 'pectin methyl-esterase'. We here describe various strategies developed by the plant to finely tune the methyl-esterification status of homogalacturonan along key events of the plant lifecycle.
Annotating the genome by DNA methylation.
Cedar, Howard; Razin, Aharon
2017-01-01
DNA methylation plays a prominent role in setting up and stabilizing the molecular design of gene regulation and by understanding this process one gains profound insight into the underlying biology of mammals. In this article, we trace the discoveries that provided the foundations of this field, starting with the mapping of methyl groups in the genome and the experiments that helped clarify how methylation patterns are maintained through cell division. We then address the basic relationship between methyl groups and gene repression, as well as the molecular rules involved in controlling this process during development in vivo. Finally, we describe ongoing work aimed at defining the role of this modification in disease and deciphering how it may serve as a mechanism for sensing the environment.
Methylation of hemoglobin to enhance flocculant performance
An inexpensive bioflocculant, bovine hemoglobin (Hb), has been covalently modified through methylation of the side chain carboxyl groups of aspartic and glutamic acid residues to improve its flocculation activity. Potentiometric titration of the recovered products showed approximately 28% degree of ...
Formal Solutions for Polarized Radiative Transfer. III. Stiffness and Instability
Janett, Gioele; Paganini, Alberto
2018-04-01
Efficient numerical approximation of the polarized radiative transfer equation is challenging because this system of ordinary differential equations exhibits stiff behavior, which potentially results in numerical instability. This negatively impacts the accuracy of formal solvers, and small step-sizes are often necessary to retrieve physical solutions. This work presents stability analyses of formal solvers for the radiative transfer equation of polarized light, identifies instability issues, and suggests practical remedies. In particular, the assumptions and the limitations of the stability analysis of Runge–Kutta methods play a crucial role. On this basis, a suitable and pragmatic formal solver is outlined and tested. An insightful comparison to the scalar radiative transfer equation is also presented.
Weak Quantum Theory: Formal Framework and Selected Applications
International Nuclear Information System (INIS)
Atmanspacher, Harald; Filk, Thomas; Roemer, Hartmann
2006-01-01
Two key concepts of quantum theory, complementarity and entanglement, are considered with respect to their significance in and beyond physics. An axiomatically formalized, weak version of quantum theory, more general than the ordinary quantum theory of physical systems, is described. Its mathematical structure generalizes the algebraic approach to ordinary quantum theory. The crucial formal feature leading to complementarity and entanglement is the non-commutativity of observables.The ordinary Hilbert space quantum mechanics can be recovered by stepwise adding the necessary features. This provides a hierarchy of formal frameworks of decreasing generality and increasing specificity. Two concrete applications, more specific than weak quantum theory and more general than ordinary quantum theory, are discussed: (i) complementarity and entanglement in classical dynamical systems, and (ii) complementarity and entanglement in the bistable perception of ambiguous stimuli
Pure spinor formalism as an N = 2 topological string
International Nuclear Information System (INIS)
Berkovits, Nathan
2005-01-01
Following suggestions of Nekrasov and Siegel, a non-minimal set of fields are added to the pure spinor formalism for the superstring. Twisted c-circumflex = 3 N = 2 generators are then constructed where the pure spinor BRST operator is the fermionic spin-one generator, and the formalism is interpreted as a critical topological string. Three applications of this topological string theory include the super-Poincare covariant computation of multiloop superstring amplitudes without picture-changing operators, the construction of a cubic open superstring field theory without contact-term problems, and a new four-dimensional version of the pure spinor formalism which computes F-terms in the spacetime action
How Formal Dynamic Verification Tools Facilitate Novel Concurrency Visualizations
Aananthakrishnan, Sriram; Delisi, Michael; Vakkalanka, Sarvani; Vo, Anh; Gopalakrishnan, Ganesh; Kirby, Robert M.; Thakur, Rajeev
With the exploding scale of concurrency, presenting valuable pieces of information collected by formal verification tools intuitively and graphically can greatly enhance concurrent system debugging. Traditional MPI program debuggers present trace views of MPI program executions. Such views are redundant, often containing equivalent traces that permute independent MPI calls. In our ISP formal dynamic verifier for MPI programs, we present a collection of alternate views made possible by the use of formal dynamic verification. Some of ISP’s views help pinpoint errors, some facilitate discerning errors by eliminating redundancy, while others help understand the program better by displaying concurrent even orderings that must be respected by all MPI implementations, in the form of completes-before graphs. In this paper, we describe ISP’s graphical user interface (GUI) capabilities in all these areas which are currently supported by a portable Java based GUI, a Microsoft Visual Studio GUI, and an Eclipse based GUI whose development is in progress.
Formalization and Implementation of Algebraic Methods in Geometry
Directory of Open Access Journals (Sweden)
Filip Marić
2012-02-01
Full Text Available We describe our ongoing project of formalization of algebraic methods for geometry theorem proving (Wu's method and the Groebner bases method, their implementation and integration in educational tools. The project includes formal verification of the algebraic methods within Isabelle/HOL proof assistant and development of a new, open-source Java implementation of the algebraic methods. The project should fill-in some gaps still existing in this area (e.g., the lack of formal links between algebraic methods and synthetic geometry and the lack of self-contained implementations of algebraic methods suitable for integration with dynamic geometry tools and should enable new applications of theorem proving in education.
TOWARDS A PHILOSOPHICAL UNDERSTANDING OF THE LOGICS OF FORMAL INCONSISTENCY
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WALTER CARNIELLI
2015-01-01
Full Text Available AbstractIn this paper we present a philosophical motivation for the logics of formal inconsistency, a family of paraconsistent logics whose distinctive feature is that of having resources for expressing the notion of consistency within the object language in such a way that consistency may be logically independent of non-contradiction. We defend the view according to which logics of formal inconsistency may be interpreted as theories of logical consequence of an epistemological character. We also argue that in order to philosophically justify paraconsistency there is no need to endorse dialetheism, the thesis that there are true contradictions. Furthermore, we show that mbC, a logic of formal inconsistency based on classical logic, may be enhanced in order to express the basic ideas of an intuitive interpretation of contradictions as conflicting evidence.
Formal modelling and analysis of socio-technical systems
DEFF Research Database (Denmark)
Probst, Christian W.; Kammüller, Florian; Hansen, Rene Rydhof
2016-01-01
systems are still mostly identified through brainstorming of experts. In this work we discuss several approaches to formalising socio-technical systems and their analysis. Starting from a flow logic-based analysis of the insider threat, we discuss how to include the socio aspects explicitly, and show......Attacks on systems and organisations increasingly exploit human actors, for example through social engineering. This non-technical aspect of attacks complicates their formal treatment and automatic identification. Formalisation of human behaviour is difficult at best, and attacks on socio-technical...... a formalisation that proves properties of this formalisation. On the formal side, our work closes the gap between formal and informal approaches to socio-technical systems. On the informal side, we show how to steal a birthday cake from a bakery by social engineering....
Formal methods for discrete-time dynamical systems
Belta, Calin; Aydin Gol, Ebru
2017-01-01
This book bridges fundamental gaps between control theory and formal methods. Although it focuses on discrete-time linear and piecewise affine systems, it also provides general frameworks for abstraction, analysis, and control of more general models. The book is self-contained, and while some mathematical knowledge is necessary, readers are not expected to have a background in formal methods or control theory. It rigorously defines concepts from formal methods, such as transition systems, temporal logics, model checking and synthesis. It then links these to the infinite state dynamical systems through abstractions that are intuitive and only require basic convex-analysis and control-theory terminology, which is provided in the appendix. Several examples and illustrations help readers understand and visualize the concepts introduced throughout the book.
The importance of training in formal methods in Software Engineering
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John Polansky
2014-12-01
Full Text Available The paradigm of formal methods provides systematic techniques and rigorous to software develop and, due the crescent complexity and quality requirements of current products, is necessary introduce them in curriculum of software engineer. In this article is analyzed the importance of train in formal methods and described specific techniques to achieved it efficiently. This techniques are the result of an experimental process in the class room of more than fifteen years in undergraduate and graduate programs, the same as company training. Also are presented a proposal a curriculum to systematic introduction of this paradigm and description of a program in training methods that has been success to industry. Results shows that students gain confidence in formal methods just when found out of the benefits of this in the context of software engineer.
Linguistic Formalism for Semi-Autonomous Reactor Operation
International Nuclear Information System (INIS)
Joo, Sungmoon; Seo, Sang Mun; Suh, Yong-Suk; Park, Cheol
2017-01-01
The ultimate goal of our work is to develop a novel, integrated system for semi-autonomous reactor operation by introducing an interfacing language shared by human reactor operators and artificially intelligent service agents (e.g., robots). We envision that human operators and artificially intelligent service agents operate the reactor cooperatively in the future. For example, an artificially intelligent service agent carries out a human reactor operator's command or reports the result of a task commanded by the human reactor operator. This work presents preliminary work towards a unified linguistic formalism for cooperative, semiautonomous reactor operation. Application of the proposed formalism to reactor operator communication domain shows that the formalism effectively captures the syntax and semantics of the domain-specific language defined by the communication protocol.
The Impact of Formal Hierarchies on Enterprise Social Networking Behavior
DEFF Research Database (Denmark)
Behrendt, Sebastian; Klier, Julia; Klier, Mathias
2015-01-01
With more and more companies using enterprise social networks (ESN) for employee communication and collaboration, the influence of ESN on organizational hierarchies has been subject of countless discussions in practice-oriented media and first academic studies. Conversely, the question whether...... and how formal organizational hierarchies influence ESN usage behavior has not yet been addressed. Drawing on a rich data set comprising 2.5 years of relationship building via direct messages, confirmed contact requests, and group messages, we are able to show that formal hierarchies have an important...... impact on social networking behavior. By applying means of social network analysis and supported by statements from interviews, we illustrate how deeply formal hierarchy impacts the three examined types of relationships. Our results motivate academics to further study the interrelation between hierarchy...
Analysis of DNA methylation in Arabidopsis thaliana based on methylation-sensitive AFLP markers.
Cervera, M T; Ruiz-García, L; Martínez-Zapater, J M
2002-12-01
AFLP analysis using restriction enzyme isoschizomers that differ in their sensitivity to methylation of their recognition sites has been used to analyse the methylation state of anonymous CCGG sequences in Arabidopsis thaliana. The technique was modified to improve the quality of fingerprints and to visualise larger numbers of scorable fragments. Sequencing of amplified fragments indicated that detection was generally associated with non-methylation of the cytosine to which the isoschizomer is sensitive. Comparison of EcoRI/ HpaII and EcoRI/ MspI patterns in different ecotypes revealed that 35-43% of CCGG sites were differentially digested by the isoschizomers. Interestingly, the pattern of digestion among different plants belonging to the same ecotype is highly conserved, with the rate of intra-ecotype methylation-sensitive polymorphisms being less than 1%. However, pairwise comparisons of methylation patterns between samples belonging to different ecotypes revealed differences in up to 34% of the methylation-sensitive polymorphisms. The lack of correlation between inter-ecotype similarity matrices based on methylation-insensitive or methylation-sensitive polymorphisms suggests that whatever the mechanisms regulating methylation may be, they are not related to nucleotide sequence variation.
Recognition of methylated DNA through methyl-CpG binding domain proteins
DEFF Research Database (Denmark)
Zou, Xueqing; Ma, Wen; Solov'yov, Ilia
2012-01-01
DNA methylation is a key regulatory control route in epigenetics, involving gene silencing and chromosome inactivation. It has been recognized that methyl-CpG binding domain (MBD) proteins play an important role in interpreting the genetic information encoded by methylated DNA (mDNA). Although...... the function of MBD proteins has attracted considerable attention and is well characterized, the mechanism underlying mDNA recognition by MBD proteins is still poorly understood. In this article, we demonstrate that the methyl-CpG dinucleotides are recognized at the MBD-mDNA interface by two MBD arginines...
Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants.
Pauwels, Sara; Ghosh, Manosij; Duca, Radu Corneliu; Bekaert, Bram; Freson, Kathleen; Huybrechts, Inge; Langie, Sabine A S; Koppen, Gudrun; Devlieger, Roland; Godderis, Lode
2017-01-01
Maternal nutrition during pregnancy and infant nutrition in the early postnatal period (lactation) are critically involved in the development and health of the newborn infant. The Maternal Nutrition and Offspring's Epigenome (MANOE) study was set up to assess the effect of maternal methyl-group donor intake (choline, betaine, folate, methionine) on infant DNA methylation. Maternal intake of dietary methyl-group donors was assessed using a food-frequency questionnaire (FFQ). Before and during pregnancy, we evaluated maternal methyl-group donor intake through diet and supplementation (folic acid) in relation to gene-specific ( IGF2 DMR, DNMT1 , LEP , RXRA ) buccal epithelial cell DNA methylation in 6 months old infants ( n = 114) via pyrosequencing. In the early postnatal period, we determined the effect of maternal choline intake during lactation (in mothers who breast-fed for at least 3 months) on gene-specific buccal DNA methylation ( n = 65). Maternal dietary and supplemental intake of methyl-group donors (folate, betaine, folic acid), only in the periconception period, was associated with buccal cell DNA methylation in genes related to growth ( IGF2 DMR), metabolism ( RXRA ), and appetite control ( LEP ). A negative association was found between maternal folate and folic acid intake before pregnancy and infant LEP (slope = -1.233, 95% CI -2.342; -0.125, p = 0.0298) and IGF2 DMR methylation (slope = -0.706, 95% CI -1.242; -0.107, p = 0.0101), respectively. Positive associations were observed for maternal betaine (slope = 0.875, 95% CI 0.118; 1.633, p = 0.0241) and folate (slope = 0.685, 95% CI 0.245; 1.125, p = 0.0027) intake before pregnancy and RXRA methylation. Buccal DNMT1 methylation in the infant was negatively associated with maternal methyl-group donor intake in the first and second trimester of pregnancy and negatively in the third trimester. We found no clear association between maternal choline intake
Methyl Iodide Decomposition at BWR Conditions
International Nuclear Information System (INIS)
Pop, Mike; Bell, Merl
2012-09-01
Based on favourable results from short-term testing of methanol addition to an operating BWR plant, AREVA has performed numerous studies in support of necessary Engineering and Plant Safety Evaluations prior to extended injection of methanol. The current paper presents data from a study intended to provide further understanding of the decomposition of methyl iodide as it affects the assessment of methyl iodide formation with the application of methanol at BWR Plants. This paper describes the results of the decomposition testing under UV-C light at laboratory conditions and its effect on the subject methyl iodide production evaluation. The study as to the formation and decomposition of methyl iodide as it is effected by methanol addition is one phase of a larger AREVA effort to provide a generic plant Safety Evaluation prior to long-term methanol injection to an operating BWR. Other testing phases have investigated the compatibility of methanol with fuel construction materials, plant structural materials, plant consumable materials (i.e. elastomers and coatings), and ion exchange resins. Methyl iodide is known to be very unstable, typically preserved with copper metal or other stabilizing materials when produced and stored. It is even more unstable when exposed to light, heat, radiation, and water. Additionally, it is known that methyl iodide will decompose radiolytically, and that this effect may be simulated using ultra-violet radiation (UV-C) [2]. In the tests described in this paper, the use of a UV-C light source provides activation energy for the formation of methyl iodide. Thus is similar to the effect expected from Cherenkov radiation present in a reactor core after shutdown. Based on the testing described in this paper, it is concluded that injection of methanol at concentrations below 2.5 ppm in BWR applications to mitigate IGSCC of internals is inconsequential to the accident conditions postulated in the FSAR as they are related to methyl iodide formation
Whole genome DNA methylation: beyond genes silencing
Tirado-Magallanes, Roberto; Rebbani, Khadija; Lim, Ricky; Pradhan, Sriharsa; Benoukraf, Touati
2016-01-01
The combination of DNA bisulfite treatment with high-throughput sequencing technologies has enabled investigation of genome-wide DNA methylation at near base pair level resolution, far beyond that of the kilobase-long canonical CpG islands that initially revealed the biological relevance of this covalent DNA modification. The latest high-resolution studies have revealed a role for very punctual DNA methylation in chromatin plasticity, gene regulation and splicing. Here, we aim to outline the ...
Variational formalism for kinetic-MHD instabilities in tokamaks
International Nuclear Information System (INIS)
Edery, D.; Garbet, X.; Roubin, J.P.; Samain, A.
1991-07-01
A variational formalism that includes in a consistent way the tokamak plasma fluid response to an electromagnetic field as well as the particle-field resonant interaction effects is presented. The integrability of the unperturbed motion of the particles is used to establish a general functional similar to the classical Lagrangian for the electromagnetic field, which is extremum with respect to the field potentials. This functional is the sum of fluid terms closely related to the classical MHD energy and of resonant terms describing the kinetic effects. The formalism is used to study a critical issue in tokamak confinement, namely the sawteeth stabilization by energetic particles
Digital system verification a combined formal methods and simulation framework
Li, Lun
2010-01-01
Integrated circuit capacity follows Moore's law, and chips are commonly produced at the time of this writing with over 70 million gates per device. Ensuring correct functional behavior of such large designs before fabrication poses an extremely challenging problem. Formal verification validates the correctness of the implementation of a design with respect to its specification through mathematical proof techniques. Formal techniques have been emerging as commercialized EDA tools in the past decade. Simulation remains a predominantly used tool to validate a design in industry. After more than 5