Sample records for foreland fold nw

  1. Linkages between orogenic plateau build-up, fold-thrust shortening, and foreland basin evolution in the Zagros (NW Iran) (United States)

    Barber, D. E.; Stockli, D. F.


    The Iranian Plateau (IP) is a thickened, low-relief morphotectonic province of diffuse deformation that formed due to Arabia-Eurasia collision and may serve as a younger analogue for the Tibetan Plateau. Despite detailed geophysical characterization of the IP, its deformation history and relationship to the Zagros fold-thrust belt and its foreland basin evolution remains unresolved. Low-temperature thermochronometry and provenance data from a transect across the internal and external Zagros track growth of the IP and delineate multiphase interaction between upper- and lower-plate processes during closure of the Neotethys and Arabia-Eurasia suturing. Inversion of zircon (U-Th)/He and fission-track data from plutonic and metamorphic basement rocks in the Sanandaj-Sirjan Zone (SSZ) of the IP reveals an initial stage of low-rate exhumation from 36-25 Ma, simultaneous with the onset of tectonic subsidence and marine incursion in the Zagros foreland basin. Overlapping apatite fission-track and (U-Th)/He ages indicate sharp acceleration in SSZ exhumation rates between 20-15 Ma, coincident with rejuvenation of foreland basin subsidence and an influx of Eurasian-derived sediments into the Zagros foreland deposited above an Oligocene unconformity. The mid-Miocene marks a transition in focused exhumation from the SSZ to Arabian lower-plate. Apatite (U-Th)/He ages suggest in-sequence fold-thrust propagation from the High Zagros to simply folded belt from 10 Ma to recent, which is reflected in the foreland by a shift in provenance to dominantly recycled Arabian-derived detritus and clastic facies progradation. Integrated thermochronometric and provenance data document a two-phase outward expansion of the Iranian Plateau and Zagros fold-thrust belt, tightly coupled to distinct phases of basin evolution and provenance shifts in the Zagros foreland. We associate multiple deformation and basin episodes with protracted collisional processes, from subduction of attenuated Arabian

  2. Landscape History of Grosses Moos, NW Swiss Alpine Foreland. (United States)

    Joanna Heer, Aleksandra; Adamiec, Grzegorz; Veit, Heinz; May, Jan-Hendrik; Novenko, Elena; Hajdas, Irka


    The western Swiss Plateau with Lake Neuchâtel is part of the alpine foreland and among the key areas for the reconstruction of environmental changes since the last postglacial. This study was carried out in a landscape located NE of the lake and called Grosses Moos (The Large Fen) - currently designated the Swiss largest, continuous farming area, after the fen was drained in course of landscape engineering projects performed in Switzerland at the end of the 19th century. The study contributes new results from nine excavations of littoral ridges identified in Grosses Moos, and integrates sedimentology, paleo-environmental analysis and three independent chronological methods. Radiocarbon dating, pollen analysis and optically stimulated luminescence (OSL) were applied to the sediments. While pollen and radiocarbon follow the standard procedures, the evaluation of the luminescence age estimates demanded adjustment according to the physical and microdosimetric properties of the alpine quartz, and consideration of the peculiarities of the changing littoral environments of Grosses Moos. The Grosses Moos landscape developed on the temporary surface of the post-Last Glacial sedimentary infill of the over-deepened glacial Aare valley. In this study the landscape history has been fitted into the existing supraregional time scales of NGRIP, the Swiss bio-zones system and the human history based on archaeological and historic records and covers a time span of up to 15'000 yr b2k. The wide-ranging suite of geomorphic features and sedimentary sequences, including littoral lake sediments, beach ridges, dunes, palaeo-channels, peat and colluvial deposits, enable the extensive reconstruction of spatially and temporally variable natural shaping processes. In addition, our results indicate remobilization of soil, colluvium, and sediment due to human settlement activities since the Neolithic - with an important increase in sediment load and spatial variability since the Bronze Age

  3. The paradox of vertical σ2 in foreland fold and thrust belts (United States)

    Tavani, Stefano


    Occurrence of aesthetically appealing thrust systems and associated large scale anticlines, in both active and fossil foreland fold and thrust belts, is commonly interpreted as an evidence for Andersonian compressional framework. Indeed, these structures would testify for a roughly vertical σ3. Such a correlation between thrusts occurrence and stress field orientation, however, frequently fails to explain denser observations at a smaller scale. The syn-orogenic deformation meso-structures hosted in exposed km-scale thrust-related folds, in fact, frequently and paradoxically witness for a syn-thrusting strike-slip stress configuration, with a near-vertical σ2 and a sub-horizontal σ3. This apparent widespread inconsistency between syn-orogenic meso-structures and stress field orientation is here named "the σ2 paradox". A possible explanation for such a paradox is provided by inherited extensional deformation structures commonly developed prior to thrusting, in the flexural foreland basins located ahead of fold and thrust belts. Thrust nucleation and propagation is facilitated and driven by the positive inversion of the extensional inheritances, and their subsequent linkage. This process eventually leads to the development of large reverse fault zones and can occur both in compressive and strike-slip stress configurations.

  4. Rock magnetism and magnetic fabric of the Triassic rocks from the West Spitsbergen Fold-and-Thrust Belt and its foreland (United States)

    Dudzisz, Katarzyna; Szaniawski, Rafał; Michalski, Krzysztof; Chadima, Martin


    Magnetic fabric and magnetomineralogy of the Early Triassic sedimentary rocks, collected along the length of the West Spitsbergen Fold-and-Thrust Belt (WSFTB) and from subhorizontal beds on its foreland, is presented with the aim to compare magnetic mineralogy of these areas, determine the carriers of magnetic fabric and identify tectonic deformation reflected in the magnetic fabric. Magnetic mineralogy varies and only in part depends on the lithology. The magnetic fabric at all sampling sites is controlled by paramagnetic minerals (phyllosilicates and Fe-carbonates). In the fold belt, it reflects the low degree of deformation in a compressional setting with magnetic lineation parallel to fold axis (NW-SE). This is consistent with pure orthogonal compression model of the WSFTB formation, but it also agrees with decoupling model. Inverse fabric, observed in few sites, is carried by Fe-rich carbonates. In the WSFTB foreland, magnetic lineation reflects the Triassic paleocurrent direction (NE-SW). The alternation between normal and inverse magnetic fabric within the stratigraphic profile could be related to sedimentary cycles.

  5. Growth of the Zagros Fold-Thrust Belt and Foreland Basin, Northern Iraq, Kurdistan (United States)

    Koshnaw, Renas; Horton, Brian; Stockli, Daniel; Barber, Douglas; Ghalib, Hafidh; Dara, Rebwar


    The Zagros orogenic belt in the Middle Eastern segment of the Alpine-Himalayan system is among the youngest seismically active continental collision zones on Earth. However, due to diachronous and incremental collision, the precise ages and kinematics of shortening and deposition remain poorly understood. The Kurdistan region of the Zagros fold-thrust belt and foreland basin contains well-preserved Neogene wedge-top and foredeep deposits that include clastic nonmarine fill of the Upper Fars, Lower Bakhtiari, and Upper Bakhtiari Formations. These deposits record significant information about orogenic growth, fold-thrust dynamics, and advance of the deformation front. Thermochronologic and geochronologic data from thrust sheets and stratigraphic archives combined with local earthquake data provide a unique opportunity to address the linkages between surface and subsurface geologic relationships. This research seeks to constrain the timing and geometry of exhumation and deformation by addressing two key questions: (1) Did the northwestern Zagros fold-thrust belt evolve from initial thin-skinned shortening to later thick-skinned deformation or vice-versa? (2) Did the fold-thrust belt advance steadily under critical/supercritical wedge conditions involving in-sequence thrusting or propagate intermittently under subcritical conditions with out-of-sequence deformation? From north to south, apatite (U-Th)/He ages from the Main Zagros Thrust, the Mountain Front Flexure (MFF), and additional frontal thrusts suggest rapid exhumation by ~10 Ma, ~5 Ma, and ~8 Ma respectively. Field observations and seismic sections indicate progressive tilting and development of growth strata within the Lower Bakhtiari Formation adjacent to the frontal thrusts and within the Upper Bakhtiari Formation near the MFF. In the Kurdistan region of Iraq, a regional balanced cross section constrained by new thermochronometric results, proprietary seismic reflection profiles, and earthquake hypocenters

  6. Evolution of the stress fields in the Zagros Foreland Folded Belt using focal mechanisms and kinematic analyses: the case of the Fars salient, Iran (United States)

    Sarkarinejad, Khalil; Zafarmand, Bahareh; Oveisi, Behnam


    The NW-SE trending Zagros orogenic belt was initiated during the convergence of the Afro-Arabian continent and the Iranian microcontinent in the Late Cretaceous. Ongoing convergence is confirmed by intense seismicity related to compressional stresses collision-related in the Zagros orogenic belt by reactivation of an early extensional faulting to latter compressional segmented strike-slip and dip-slip faulting. These activities are strongly related either to the deep-seated basement fault activities (deep-seated earthquakes) underlies the sedimentary cover or gently dipping shallow-seated décollement horizon of the rheological weak rocks of the infra-Cambrian Hormuz salt. The compressional stress regimes in the different units play an important role in controlling the stress conditions between the different units within the sedimentary cover and basement. A significant set of nearly N-S trending right-lateral strike-slip faults exists throughout the study area in the Fars area in the Zagros Foreland Folded Belt. Fault-slip and focal mechanism data were analyzed using the stress inversion method to reconstruct the paleo and recent stress conditions. The results suggest that the current direction of maximum principal stress averages N19°E, with N38°E that for the past from Cretaceous to Tertiary (although a few sites on the Kar-e-Bass fault yield a different direction). The results are consistent with the collision of the Afro-Arabian continent and the Iranian microcontinent. The difference between the current and paleo-stress directions indicates an anticlockwise rotation in the maximum principle stress direction over time. This difference resulted from changes in the continental convergence path, but was also influenced by the local structural evolution, including the lateral propagation of folds and the presence of several local décollement horizons that facilitated decoupling of the deformation between the basement and the sedimentary cover. The obliquity of

  7. Neogene shortening and exhumation of the Zagros fold-thrust belt and foreland basin in the Kurdistan region of northern Iraq (United States)

    Koshnaw, Renas I.; Horton, Brian K.; Stockli, Daniel F.; Barber, Douglas E.; Tamar-Agha, Mazin Y.; Kendall, Jerome J.


    The Zagros fold-thrust belt in the Kurdistan region of Iraq encroached southward toward a rapidly subsiding Neogene foreland basin and was later partitioned by out-of-sequence shortening focused along the Mountain Front Flexure (MFF), as defined by new low-temperature thermochronologic, stratigraphic, and provenance results. Apatite (U-Th)/He ages document rapid deformation advance from the Main Zagros Fault to southern frontal structures (Kirkuk, Shakal, and Qamar thrusts) at 10-8 Ma, followed by potential basement-involved out-of-sequence development of the MFF (Qaradagh anticline) by 5 Ma. Distinct shifts in detrital zircon U-Pb provenance signatures for Neogene foreland basin fill provide evidence for drainage reorganization during fold-thrust belt advance. U-Pb age spectra and petrologic data from the Injana (Upper Fars) Formation indicate derivation from a variety of Eurasian, Pan-African, ophiolitic and Mesozoic-Cenozoic volcanic terranes, whereas the Mukdadiya (Lower Bakhtiari) and Bai-Hasan (Upper Bakhtiari) Formations show nearly exclusive derivation from the Paleogene Walash-Naopurdan volcanic complex near the Iraq-Iran border. Such a sharp cutoff in Eurasian, Pan-African, and ophiolitic sources is likely associated with drainage reorganization and tectonic development of the geomorphic barrier formed by the MFF. As a result of Zagros crustal shortening, thickening and loading, the Neogene foreland basin developed and accommodated an abrupt influx of fluvial clastic sediment that contains growth stratal evidence of synkinematic accumulation. The apparent out-of-sequence pattern of upper crustal shortening in the hinterland to foreland zone of Iraqi Kurdistan suggests that structural inheritance and the effects of synorogenic erosion and accumulation are important factors influencing the irregular and episodic nature of orogenic growth in the Zagros.

  8. Structural, micro-structural and kinematic analyses of channel flow in the Karmostaj salt diapir in the Zagros foreland folded belt, Fars province, Iran (United States)

    Sarkarinejad, Khalil; Sarshar, Maryam Asadi; Adineh, Sadegh


    One of the main characteristic of the Zagros foreland fold-and-thrust belt and the Zagros foreland folded belt are wide distributions of surface extrusion from the Hormuz salt diapirs. This study examines the structure and kinematic of channel flow in the Karmostaj salt diapir in the southwestern part of the Zagros foreland folded belt. This diapir has reached the surface as a result of the channel flow mechanism and has extruded in the southern limb of the Kuh-Gach anticline which is an asymmetric décollement fold with convergence to the south. Structural and microstructural studies and quantitative finite strain (Rs) and kinematic vorticity number (Wk) analyses were carried out within this salt diapir and its namakier. This was in order to investigate the structural evolution in the salt diapiric system, the characteristics and mechanism of the salt flow and the distribution of flow regimes within the salt diapir and interaction of regional tectonics and salt diaprism. The extruded salt has developed a flow foliation sub-parallel to the remnant bedding recorded by different colors, a variety of internal folds including symmetrical and asymmetrical folds and interference fold patterns, shear zones, and boudins. These structures were used to analyze mechanisms and history of diapiric flow and extrusion. The microstructures, reveal various deformation mechanisms in various parts of salt diapir. The measurements of finite strain show that Rs values in the margin of salt diapir are higher than within its namakier which is consistent with the results of structural studies. Mean kinematic vorticity number (Wm) measured in steady state deformation of diapir and namakier is Wm = 0.45-0.48 ± 0.13. The estimated mean finite deformation (Wm) values indicate that 67.8% pure shear and 32.2% simple shear deformation were involved; the implications of which are discussed. The vorticity of flow indicates that in the early stage of growth, Poiseuille flow was the dominate

  9. Sediment provenance in contractional orogens: The detrital zircon record from modern rivers in the Andean fold-thrust belt and foreland basin of western Argentina (United States)

    Capaldi, Tomas N.; Horton, Brian K.; McKenzie, N. Ryan; Stockli, Daniel F.; Odlum, Margaret L.


    This study analyzes detrital zircon U-Pb age populations from Andean rivers to assess whether active synorogenic sedimentation accurately records proportional contributions from varied bedrock source units across different drainage areas. Samples of modern river sand were collected from west-central Argentina (28-33°S), where the Andes are characterized by active uplift and deposition in diverse contractional provinces, including (1) hinterland, (2) wedge-top, (3) proximal foreland, and (4) distal broken foreland basin settings. Potential controls on sediment provenance were evaluated by comparing river U-Pb age distributions with predicted age spectra generated by a sediment mixing model weighted by relative catchment exposure (outcrop) areas for different source units. Several statistical measures (similarity, likeness, and cross-correlation) are employed to compare how well the area-weighted model predicts modern river age populations. (1) Hinterland basin provenance is influenced by local relief generated along thrust-bounded ranges and high zircon fertility of exposed crystalline basement. (2) Wedge-top (piggyback) basin provenance is controlled by variable lithologic durability among thrust-belt bedrock sources and recycled basin sediments. (3) Proximal foreland (foredeep) basin provenance of rivers and fluvial megafans accurately reflect regional bedrock distributions, with limited effects of zircon fertility and lithologic durability in large (>20,000 km2) second-order drainage systems. (4) In distal broken segments of the foreland basin, regional provenance signatures from thrust-belt and hinterland areas are diluted by local contributions from foreland basement-cored uplifts.


    Directory of Open Access Journals (Sweden)



    Full Text Available This paper suggests that the structure known as "Beypazarı flexure / monocline" in the Turkish geology literature should be named as "Beypazarı fault-propagation folds". Beypazarı, Kilci and Başören blind thrusts together with Erenler back thrust constitute the Beypazarı Blind Thrust Zone which is an active neotectonic structure as indicated by earthquake activity. NW-SE contraction created by the interaction between the North Anatolian Fault Zone, the Kırıkkale-Erbaa Fault Zone and the Eskişehir Fault Zone produced the Eldivan-Elmadağ Pinched Crustal Wedge, the Abdüsselam Pinched Crustal Wedge and the Beypazarı Blind Thrust Zone. These structures take up the internal deformation of the Anatolian Plate.

  11. Detrital-zircon fission-track geochronology of the Lower Cenozoic sediments, NW Himalayan foreland basin: Clues for exhumation and denudation of the Himalaya during the India-Asia collision (United States)

    Jain, A.; Lal, N.; Suelmani, B.; Awasthi, A. K.; Singh, S.; Kumar, R.


    Detrital-zircon fission-track geochronology of the synorogenically-deposited Subathu-Dagshai-Kasauli-Lower Siwalik Formations of the Sub-Himalayan Lower Cenozoic foreland basin reflects progressive effects of the Himalayan tectonometamorphic events on the Proterozoic-Paleozoic source rock as a consequence of the India-Asia collision. The oldest transgressive marine Subathu Formation (57.0-41.5 Ma) contains a very dominant 302.4 ± 21.9 Ma old detrital zircon FT suite with a few determinable 520.0 Ma grains. This old suite was derived by mild erosion of the Zircon Partially Annealed Zone (ZPAZ) of 240-180 oC, which affected the Himalayan Proterozoic basement and its Tethyan sedimentary cover as a consequence of first imprint of the collision. In addition, 50.0 Ma old detrital zircons in this formation were derived possibly from the Indus Tsangpo Suture Zone and the Trans-Himalayan Ladakh Batholith. Sudden source rock changes and unroofing are manifested in the overlying fluvial Dagshai (~30-20 Ma) and Kasauli (20-13 Ma) molassic sediments, which are characterised by dominant 30.0 and 25.0 Ma old youngest zircon FT peaks, respectively. A distinct unconformity spanning for about 10 Myr gets established between the Subathu-Dagshai formations on the basis of detrital- zircon FT ages. Molassic sedimentation since ~30 Ma coincides with the depletion of detritus from the suture zone, and the bulk derivation from the main Higher Himalayan source rock, which has undergone sequentially the UHP-HP-amphibolite facies metamorphism (53-40 Ma) in the extreme north and widespread Eo- and Neo-Himalayan tectonothermal events in the middle. Strength of the Pre-Himalayan Peaks (PHP) >50 Ma in these younger sediments gradually decreases with the intensification of the Himalayan thermal events till the end of the Kasauli sedimentation. Widespread Eo- and Neo-Himalayan metamorphic events (40.0-30.0 and 25.0-15.0 Ma) have almost remobilised the provenance and obliterated most of the

  12. Linking orogen and peripheral foreland basin: conceptual model and application to the Southalpine-Dinaric (Friuli) orocline (United States)

    Heberer, Bianca; Neubauer, Franz


    Surface uplift and rock exhumation within an orogen are generally a consequence of convergence, and can often be linked with subsidence in a peripheral foreland. Since vertical loads act on the entire lithosphere, these processes can, therefore, be considered as plate-scale processes. Here, we propose a conceptual model for this linkage for the Friuli orocline and its surrounding units. The Friuli orocline stretches from the ENE-trending Southern Alps to the SE-trending Dinarides. There, two Neogene stages of convergence and associated deformation can be differentiated: (1) a Mid-Late Miocene phase of increased surface uplift and intra-orogenic subsidence of sedimentary basins reflecting intra-orogenic crustal-scale folding. Depocentres are e.g. the flexural Belluno, Ljubljana and Klagenfurt basins. (2) A second stage of convergence during Late Pliocene-Pleistocene times led to overall surface uplift in the orogen and contemporaneous pronounced subsidence in the peripheral foreland basin (Venetian platform and the northern Adriatic Sea). We propose, that the spatially variable extent of subsidence originates in variably strong orogen-basin coupling, i.e. weak coupling during stage 1 vs. strong coupling during stage 2. This interpretation is based on the apatite fission track age pattern, the distribution of intra-orogenic Neogene sediment basins and subsidence analyses in the foreland basin (Barbieri et al., 2007). Available low-temperature thermochronological data for the Southern Alps and the NW Dinarides are sparse, in contrast to a dense network of primarily apatite fission track ages north of the Periadriatic lineament (e.g. summarized by Luth & Willingshofer, 2008). AFT ages adjacent to the eastern Periadriatic Lineament mainly range from 15 to 25 Ma (Hejl, 1997; Fodor et al., 2008). Detrital studies on Oligocene to Miocene sediments from the Venetian foreland basin yielded dominant age groups clustering roughly around 20 and 30 Ma (Stefani et al., 2008

  13. Detrital zircon U-Pb and (U-Th)/He double-dating of Upper Cretaceous-Cenozoic Zagros foreland basin strata in the Kurdistan Region of northern Iraq (United States)

    Barber, D. E.; Stockli, D. F.; Koshnaw, R. I.; Horton, B. K.; Tamar-Agha, M. Y.; Kendall, J. J.


    The NW Zagros orogen is the result of the multistage collisional history associated with Late Cretaceous-Cenozoic convergence of the Arabian and Eurasian continents and final closure of Neotethys. Siliciclastic strata preserved within a ~400 km segment of the NW Zagros fold-thrust belt and foreland basin in the Iraqi Kurdistan Region (IKR) provide a widespread record of exhumation and sedimentation. As a means of assessing NW Zagros foreland basin evolution and chronostratigraphy, we present coupled detrital zircon (DZ) U-Pb and (U-Th)/He geo-thermochronometric data of Upper Cretaceous to Pliocene siliciclastic strata from the Duhok, Erbil, and Suleimaniyah provinces of IKR. LA-ICP-MS U-Pb age analyses reveal that the foreland basin fill in IKR in general was dominantly derived from Pan-African/Arabian-Nubian, Peri-Gondwandan, Eurasian, and Cretaceous volcanic arc terrenes. However, the provenance of these strata varies systematically along strike and through time, with an overall increase in complexity upsection. DZ age distribution of Paleocene-Eocene strata is dominated by a ~95 Ma grain age population, likely sourced from the Late Cretaceous Hassanbag-Bitlis volcanic arc complex along the northern margin of Arabia. In contrast, DZ U-Pb age distributions of Neogene strata show a major contribution derived from various Eurasian (e.g., Iranian, Tauride, Pontide; ~45, 150, 300 Ma) and Pan-African (~550, 950 Ma) sources. The introduction of Eurasian DZ ages at the Paleogene-Neogene transition likely records the onset of Arabian-Eurasian collision. Along strike to the southeast, the DZ U-Pb spectra of Neogene strata show a decreased percentage of Pan-African, Peri-Gondwandan, Tauride, and Ordovician ages, coupled with a dramatic increase in 40-50 Ma DZ ages that correspond to Urumieh-Dokhtar magmatic rocks in Iran. Combined with paleocurrent data, this suggests that Neogene sediments were transported longitudinally southeastward through an unbroken foreland basin

  14. Effects of Flat Slab Subduction on Andean Thrust Kinematics and Foreland Basin Evolution in Western Argentina (United States)

    Horton, B. K.; Fuentes, F.; McKenzie, N. R.; Constenius, K. N.; Alvarado, P. M.


    Debate persists over the effects of flat-slab subduction on the kinematics of overriding plate deformation and the evolution of retroarc sedimentary basins. In western Argentina, major spatial and temporal variations in the geometry of the subducting Nazca slab since ~15 Ma provide opportunities to evaluate the late Cenozoic response of the Andean fold-thrust belt and foreland basin to subhorizontal subduction. Preliminary results from several structural and sedimentary transects spanning the frontal thrust belt and foreland basin system between 31°S and 35°S reveal Oligocene-middle Miocene hinterland exhumation during normal-slab subduction followed thereafter by progressive slab shallowing with initial rapid cratonward propagation of ramp-flat thrust structures (prior to basement-involved foreland uplifts) and accompanying wholesale exhumation and recycling of the early Andean foreland basin (rather than regional dynamic subsidence). Detrital zircon U-Pb geochronologic data prove instrumental for revealing shifts in thrust-belt exhumation, defining depositional ages within the foreland basin, and constraining the timing of activity along frontal thrust structures. In both the San Juan (31-32°S) and Malargüe (34-35°S) segments of the fold-thrust belt, geochronological results for volcaniclastic sandstones and syndeformational growth strata are consistent with a major eastward advance in shortening at 12-9 Ma. This episode of rapid thrust propagation precedes the reported timing of Sierras Pampeanas basement-involved foreland uplifts and encompasses modern regions of both normal- and flat-slab subduction, suggesting that processes other than slab dip (such as inherited crustal architecture, critical wedge dynamics, and arc magmatism) are additional regulators of thrust-belt kinematics and foreland basin evolution.

  15. Linking Late Cretaceous to Eocene Tectonostratigraphy of the San Jacinto Fold Belt of NW Colombia With Caribbean Plateau Collision and Flat Subduction (United States)

    Mora, J. Alejandro; Oncken, Onno; Le Breton, Eline; Ibánez-Mejia, Mauricio; Faccenna, Claudio; Veloza, Gabriel; Vélez, Vickye; de Freitas, Mario; Mesa, Andrés.


    Collision with and subduction of an oceanic plateau is a rare and transient process that usually leaves an indirect imprint only. Through a tectonostratigraphic analysis of pre-Oligocene sequences in the San Jacinto fold belt of northern Colombia, we show the Late Cretaceous to Eocene tectonic evolution of northwestern South America upon collision and ongoing subduction with the Caribbean Plate. We linked the deposition of four fore-arc basin sequences to specific collision/subduction stages and related their bounding unconformities to major tectonic episodes. The Upper Cretaceous Cansona sequence was deposited in a marine fore-arc setting in which the Caribbean Plate was being subducted beneath northwestern South America, producing contemporaneous magmatism in the present-day Lower Magdalena Valley basin. Coeval strike-slip faulting by the Romeral wrench fault system accommodated right-lateral displacement due to oblique convergence. In latest Cretaceous times, the Caribbean Plateau collided with South America marking a change to more terrestrially influenced marine environments characteristic of the upper Paleocene to lower Eocene San Cayetano sequence, also deposited in a fore-arc setting with an active volcanic arc. A lower to middle Eocene angular unconformity at the top of the San Cayetano sequence, the termination of the activity of the Romeral Fault System, and the cessation of arc magmatism are interpreted to indicate the onset of low-angle subduction of the thick and buoyant Caribbean Plateau beneath South America, which occurred between 56 and 43 Ma. Flat subduction of the plateau has continued to the present and would be the main cause of amagmatic post-Eocene deposition.

  16. Structural development and stress evolution of an arcuate fold-and-thrust system, southwestern Greater Caucasus, Republic of Georgia (United States)

    Tibaldi, A.; Bonali, F. L.; Russo, E.; Pasquarè Mariotto, F. A.


    The southern front of the Greater Caucasus is quite rectilinear in plan view, with the exception of part of the Rioni Basin, where marine and continental deposits of Cretaceous-Neogene age were locally folded and uplifted; this resulted in the formation of an arcuate fold-and-thrust system that extends 45 km into the foreland. Although previous studies suggested that this system has developed only since Miocene times, our new detailed and systematic field measurements of brittle and ductile structures show a very complex history, consisting in four main phases of brittle deformation and folding, dated from Eocene to Quaternary times. We collected microtectonic data at 248 faults, and calculated the related paleostress tensors. The first two phases which we document here, predated folding and were characterised by dominant transcurrent faulting and subordinate reverse motions; the greatest principal stress σ1 was perpendicular and later parallel to the mountain belt. Afterwards, NW-SE, E-W and NE-SW trending, south-vergent asymmetrical folds started to form. In the western sector of the study area, folds are sinuous in plan view, whereas to the east they show a left-stepping, en-échelon geometry. Another two, brittle deformation phases took place after the folding, due to the activity of a set of right-lateral, strike-slip faults that strike NW-SE and NE-SW, respectively, as well as by left-lateral strike-slip faults, mostly striking NW-SE, NE-SW and NNE-SSW. These two additional phases were produced by a NE-SW to N-S trending σ1. The arcuate belt is marked by along-strike variations in the tectonic regime and deformation geometry, plus belt-parallel stretching. Based on our field data, integrated with published analogue models, we suggest a possible explanation for the Rioni structure, in terms of the oblique, asymmetric indentation of an upper crustal blocks moving to the SSW.

  17. Structural setting of the Metán Basin (NW Argentina): new insights from 2D seismic profiles (United States)

    Conti, Alessia; Maffucci, Roberta; Bigi, Sabina; Corrado, Sveva; Giordano, Guido; Viramonte, José G.


    The Metán Basin is located in the sub-Andean foreland, in the southernmost portion of the Santa Barbara system structural province (NW Argentina). The upper crust in this region shows a strong segmentation due to inherited stratigraphic and structural discontinuities, related to a Palaeozoic orogenic event and to a Cretaceous to Paleogene rifting event (Kley et al., 1999; Iaffa et al., 2011). This study seeks to unravel the deep structural setting of the basin, in order to better understand the tectonic evolution of the area. Different seismic sections are analysed, located in the Metán basin and acquired by YPF (Yacimientos Petrolíferos Fiscales, former national oil company of Argentina) in different surveys during the '70s - '80s. Stratigraphic control for the seismic interpretation is provided by petroleum exploratory wells drilled in the basin; they show a stratigraphic succession of syn-rift and post-rift deposits, mainly constituted by a continental succession of red beds, with minor limestone intercalations (Salta Group), overlain by a thick continental foreland basin succession (Orán Group) (Salfity et al., 1981). From a structural point of view, the Metán basin is characterized by a variety of structural trends, with thrust faults and related folds mainly trending N-S, NE-SW and NNE-SSW. Different mechanism can be responsible for the folding of the sedimentary cover; hangingwall anticlines are represented both by high angle thrust faults produced by inversion of Cretaceous extensional faults (Maffucci et al., 2015), and by fault propagation folds formed during the Andean shortening event. The study of the interaction between the older reactivated faults and the newly generated ones could provide new insights to unravel the complex structural setting of the area. References Iaffa D. N., Sàbat, F., Muñoz, J.A., Mon, R., Gutierrez, A.A., 2011. The role of inherited structures in a foreland basin evolution. The Metán Basin in NW Argentina. Journal of

  18. Controls of structural inheritance on orogenic curvature and foreland basin sedimentation: Insights from the Przemyśl area, Western Carpathians (United States)

    Szaniawski, Rafał; Mazzoli, Stefano; Jankowski, Leszek


    Orogenic curvatures can have various origins and are widely debated worldwide. In the Poland-Ukraine border area, the Outer Western Carpathians are characterized by a marked curvature. The origin of this curvature was analysed by integrating stratigraphic information with structural constraints and anisotropy of the magnetic susceptibility (AMS) data. Hangingwall frontal ramp domains are characterized by a relatively simple deformation dominated by layer-parallel shortening and folding around a regional NW-SE trending axis, recorded by an AMS lineation with a similar trend. On the other hand, the N-S trending hangingwall oblique ramp domain is characterized by maximum AMS axes recording transpressional strain either dominated by simple shear (sub-horizontal AMS lineation) or pure shear (steeply plunging AMS lineation) components. Early Miocene basin inversion with two distinct depocentres created a number of different detachment surfaces and thickness variations for the sedimentary successions involved in thrusting. The main depocentre of the Lower-Middle Miocene foredeep was originally located in the recess area of the curved Carpathian front. On the other hand, the occurrence of a salient to the west resulted in the axial zone of the foreland flexure being filled with allochthonous units, thereby dramatically reducing the accommodation space for foredeep sediments in this area. Our results suggest that thrust-belt geometry was controlled by the inherited Mesozoic extensional basin architecture.

  19. Late Cenozoic transpressional mountain building directly north of the Altyn Tagh Fault in the Sanweishan and Nanjieshan, North Tibetan Foreland, China (United States)

    Cunningham, Dickson; Zhang, Jin; Li, Yanfeng


    For many tectonicists, the structural development of the northern Tibetan Plateau stops at the Altyn Tagh Fault (ATF). This study challenges that assumption. Structural field observations and remote sensing analysis indicate that the Sanweishan and Nanjieshan basement cored ridges of the Archean Dunhuang Block, which interrupt the north Tibetan foreland directly north of the ATF, are bound and cut by an array of strike-slip, thrust and oblique-slip faults that have been active in the Quaternary and remain potentially active. The Sanweishan is a SE-tilted block that is bound on its NW margin by a steep south-dipping thrust fault that has also accommodated sinistral strike-slip displacements. The Nanjieshan consists of parallel, but offset basement ridges that record NNW and SSE thrust displacements and sinistral strike-slip. Regional folds characterize the extreme eastern Nanjieshan and appear to have formed above blind thrust faults which break the surface further west. Previously published magnetotelluric data suggest that the major faults of the Sanweishan and Nanjieshan ultimately root to the south within conductive zones that are inferred to merge into the ATF. Therefore, although the southern margin of the Dunhuang Block focuses significant deformation along the ATF, the adjacent cratonic basement to the north is also affected. Collectively, the ATF and structurally linked Sanweishan and Nanjieshan fault array represent a regional asymmetric half-flower structure that is dominated by non-strain partitioned sinistral transpression. The NW-trending Dengdengshan thrust fault system near Yumen City appears to define the northeastern limit of the Sanweishan-Nanjieshan block, which may be regionally viewed as the most northern, but early-stage expression of Tibetan Plateau growth into a slowly deforming, mechanically stiff Archean craton.

  20. Miocene block uplift and basin formation in the Patagonian foreland: The Gastre Basin, Argentina (United States)

    Bilmes, A.; D'Elia, L.; Franzese, J. R.; Veiga, G. D.; Hernández, M.


    The intraplate fault-block mountains and intermontane deposits of the Gastre Basin, which are recorded more than 550 km east of the Andean trench in central Patagonia, Argentina, are analyzed. The Gastre Basin is one of the largest Patagonian intermontane basins, limited by uplifted blocks strongly oblique to the Andean chain. It was originated by reverse faulting and inversion of pre-existing normal faults associated with a Mesozoic rift basin and defined by older crustal heterogeneities. The deformational event occurred during the middle Miocene, related to a short contractional episode (16.1-14.86 Ma), probably in response to an eastward migration of the Andean fold and thrust belt. During Pliocene to Quaternary times, neither younger fault-block uplifts nor reconfigurations of the basin occurred. Similarities between the study area and other parts of the Patagonian foreland - such as the presence of Miocene reverse or inversion tectonics, as well as the accommodation of the Miocene sedimentary successions - suggest that the Gastre Basin is part of a major late early to middle Miocene broken foreland system (i.e. the Patagonian broken foreland) that exhumed discrete fault-block mountains and generated contemporary basins along more than 950 km parallel to the Andean trench (i.e. between 40°00' and 48°00' south latitude). Based on recent studies on the southern Andean Margin, this continental-scale contractional episode may be the result of a flat-slab subduction segment. Nevertheless, such a hypothesis is very difficult to support when analyzing such a large flat subduction segment along the entire Patagonian trench. This suggests the need to consider alternative flat-slab trigger mechanisms or other factors in the generation of broken foreland systems.

  1. Crustal structure and evolution of the NW Zagros Mountains (Iran): Insights from numerical modeling of the interplay between surface and tectonic processes (United States)

    Saura, Eduard; Garcia-Castellanos, Daniel; Casciello, Emilio; Vergés, Jaume


    Protracted Arabia-Eurasia convergence resulted in the closure of the >2000 km wide Neo-Tethys Ocean from early Late Cretaceous to Recent. This process was controlled by the structure of the NE margin of the Arabian plate, the NE-dipping oceanic subduction beneath Eurasia, the obduction of oceanic lithosphere and the collision of small continental and volcanic arc domains of the SW margin of Eurasia. The evolution of the Zagros Amiran and Mesopotamian foreland basins is studied in this work along a ~700 km long transect in NW Zagros constrained by field, seismic and published data. We use the well-defined geometries and ages of the Amiran and Mesopotamian foreland basins to estimate the elastic thickness of the lithosphere and model the evolution of the deformation to quantitatively link the topographic, tectonic and sedimentary evolution of the system. Modelling results show two major stages of emplacement. The obduction (pre-collision) stage involves the thin thrust sheets of the Kermanshah complex together with the Bisotun basement. The collision stage corresponds to the emplacement of the basement duplex and associated crustal thickening, coeval to the out of sequence emplacement of Gaveh Rud and Imbricated Zone in the hinterland. The geodynamic model is consistent with the history of the foreland basins, with the regional isostasy model, and with a simple scenario for the surface process efficiency. The emplacement of Bisotun basement during obduction tectonically loaded and flexed the Arabian plate triggering deposition in the Amiran foreland basin. The basement units emplaced during the last 10 My, flexed the Arabian plate below the Mesopotamian basin. During this stage, material eroded from the Simply Folded belt and the Imbricated zone was not enough to fill the Mesopotamian basin, which, according to our numerical model results, required a maximum additional sediment supply of 80 m/Myr. This additional supply had to be provided by an axial drainage system

  2. Contributions of gravity and field data on the structural scheme updating of the Tellian domain and its foreland (Nefza-Bizerte region, northern Tunisia) (United States)

    Essid, El Mabrouk; Kadri, Ali; Balti, Hadhemi; Gasmi, Mohamed; Zargouni, Fouad


    The Nefza-Bizerte region, eastern part of the Tunisian Alpine chain, covers the thrust sheets domain called the Tell and its Atlassic foreland. The deep structures under the Tellian thrust sheets are not enough explored. The structural interpretation of magmatic rocks, Triassic outcrops and the depressions are still a subject of discussion. In this work, we intend to investigate deep faults and their eventual role in magmatism and Triassic salt setting up and to explain the depression genesis. Analysis of the Bouguer anomaly map and its derivatives reveals the main gravity lineaments, organized in major NE- and NW-trending systems. The NE-trending system, dipping towards the NW, is the main component of the structural scheme and has controlled the tectonic evolution of this area. After the immobilization of the Tellian thrust sheets during the uppermost Langhian, the Tell and its Atlassic foreland were affected by the Tortonian compressive event with a NW-trending maximum horizontal stress. The reverse kinematics of the NE-trending deep-seated faults created at their front continental environments filled later by post-nappes Neogene deposits. After the early Pleistocene, a NNW-directed compressional stress regime deformed the post-nappes Neogene series and generated NW-trending grabens. This coexistence of compression-extension continues until present day.

  3. Seismotectonics of thin- and thick-skinned deformation in the Andean foreland from local network data - Evidence for a seismogenic lower crust (United States)

    Smalley, Robert, Jr.; Isacks, Bryan L.


    Local network data from San Juan, Argentina, provides new information about crustal seismicity in the Andean foreland above a horizontal segment of the subducted Nazca Plate. Two areas of foreland seismicity are found, one associated with the Sierras Pampeanas basement uplifts, and the other beneath, but not within, the Precordillera foreland fold-thrust belt. The Precordillera seismicity provides direct evidence for basement deformation beneath the sediments of the thrust belt and supports the idea that its eastern part is significantly modified by underlying basement deformation. In both areas, events are concentrated between 15 and 35 km depth and have volumetric, rather than planar, faultlike distributions. The depth distribution is unusually deep for intraplate earthquakes and suggests a brittle-ductile transition near 30-35 km.

  4. Seismic characterization of a `compound tectonic wedge` beneath the Rocky Mountain foreland basin, Alberta

    Energy Technology Data Exchange (ETDEWEB)

    Lawton, D. C.; Sukaramongkol, C.; Spratt, D. A. [Calgary Univ., AB (Canada). Dept. of Geology and Geophysics


    The detailed internal geometry of a `compound tectonic wedge` beneath an eastward-dipping homocline in the Sundre area of southern Alberta was described. Data for the description was obtained by interpreting reflection seismic data. The wedge has been driven into the foreland succession beneath the gently dipping upper detachment which occurs within coal horizons of the Upper Brazeau Group. Shape of the upper detachment near its toe indicates that rocks in its hanging wall were decoupled from strain associated with forward emplacement of the wedge. Folding of the upper detachment occurs in the hinterland region of the wedge, with a new upper detachment developing above the fold. Emplacement of the wedge is suspected to be the result of excess pore fluid pressure, although proof of this happening awaits quantification of the mechanical model. 25 refs., 8 figs.

  5. Foreland sedimentary record of Andean mountain building during advancing and retreating subduction (United States)

    Horton, Brian K.


    As in many ocean-continent (Andean-type) convergent margins, the South American foreland has long-lived (>50-100 Myr) sedimentary records spanning not only protracted crustal shortening, but also periods of neutral to extensional stress conditions. A regional synthesis of Andean basin histories is complemented by new results from the Mesozoic Neuquén basin system and succeeding Cenozoic foreland system of west-central Argentina (34-36°S) showing (1) a Late Cretaceous shift from backarc extension to retroarc contraction and (2) an anomalous mid-Cenozoic (~40-20 Ma) phase of sustained nondeposition. New detrital zircon U-Pb geochronological results from Jurassic through Neogene clastic deposits constrain exhumation of the evolving Andean magmatic arc, retroarc thrust belt, foreland basement uplifts, and distal eastern craton. Abrupt changes in sediment provenance and distal-to-proximal depositional conditions can be reconciled with a complex Mesozoic-Cenozoic history of extension, post-extensional thermal subsidence, punctuated tectonic inversion involving thick- and thin-skinned shortening, alternating phases of erosion and rapid accumulation, and overlapping igneous activity. U-Pb age distributions define the depositional ages of several Cenozoic stratigraphic units and reveal a major late middle Eocene-earliest Miocene (~40-20 Ma) hiatus in the Malargüe foreland basin. This boundary marks an abrupt shift in depositional conditions and sediment sources, from Paleocene-middle Eocene distal fluviolacustrine deposition of sediments from far western volcanic sources (Andean magmatic arc) and subordinate eastern cratonic basement (Permian-Triassic Choiyoi igneous complex) to Miocene-Quaternary proximal fluvial and alluvial-fan deposition of sediments recycled from emerging western sources (Malargüe fold-thrust belt) of Mesozoic basin fill originally derived from basement and magmatic arc sources. Neogene eastward advance of the fold-thrust belt involved thick

  6. Strain partitioning in the footwall of the Somiedo Nappe: structural evolution of the Narcea Tectonic Window, NW Spain (United States)

    Gutiérrez-Alonso, Gabriel


    The Somiedo Nappe is a major thrust unit in the Cantabrian Zone, the external foreland fold and thrust belt of the North Iberian Variscan orogen. Exposed at the Narcea Tectonic Window are Precambrian rocks below the basal decollement of the Somiedo Nappe, which exhibit a different deformation style than the overlying Paleozoic rocks above the basal decollement. During Variscan deformation, folding and widespread subhorizontal, bedding-parallel decollements were produced in the hanging wall within the Paleozoic rocks. Vertical folding, with related axial-planar cleavage at a high angle to the decollement planes, developed simultaneously in the upper Proterozoic Narcea Slates of the footwall, below the detachment. The relative magnitude of finite strain, measured in the footwall rocks, diminishes towards the foreland. These observations indicate that (1) significant deformation may occur in the footwall of foreland fold and thrust belts, (2) the shortening mechanism in the footwall may be different from that of the hanging wall, and (3) in this particular case, the partitioning of the deformation implies the existence of a deeper, blind decollement surface contemporaneous with the first stages of the foreland development, that does not crop out in the region. This implies a significant shortening in the footwall, which must be taken into account when restoration and balancing of cross-sections is attempted. A sequential diagram of the evolution of the Narcea Tectonic Window with a minimum shortening of 85 km is proposed, explaining the complete Variscan evolution of the foreland to hinterland transition in the North Iberian Variscan orogen.

  7. Characterization of the seismically imaged Tuscarora fold system and implications for layer parallel shortening in the Pennsylvania salient (United States)

    Mount, Van S.; Wilkins, Scott; Comiskey, Cody S.


    The Tuscarora fold system (TFS) is located in the Pennsylvania salient in the foreland of the Valley and Ridge province. The TFS is imaged in high quality 3D seismic data and comprises a system of small-scale folds within relatively flat-lying Lower Silurian Tuscarora Formation strata. We characterize the TFS structures and infer layer parallel shortening (LPS) directions and magnitudes associated with deformation during the Alleghany Orogeny. Previously reported LPS data in our study area are from shallow Devonian and Carboniferous strata (based on outcrop and core analyses) above the shallowest of three major detachments recognized in the region. Seismic data allows us to characterize LPS at depth in strata beneath the shallow detachment. Our LPS data (orientations and inferred magnitudes) are consistent with the shallow data leading us to surmise that LPS during Alleghanian deformation fanned around the salient and was distributed throughout the stratigraphic section - and not isolated to strata above the shallow detachment. We propose that a NW-SE oriented Alleghanian maximum principal stress was perturbed by deep structure associated with the non-linear margin of Laurentia resulting in fanning of shortening directions within the salient.

  8. Human behaviour towards climatic change during the 4th millennium BC in the Swiss Alpine forelands

    DEFF Research Database (Denmark)

    Karg, Sabine

    Human behaviour towards climatic change during the 4th millennium BC in the Swiss Alpine forelands.......Human behaviour towards climatic change during the 4th millennium BC in the Swiss Alpine forelands....

  9. Seismotectonics of Bhutan: Evidence for segmentation of the Eastern Himalayas and link to foreland deformation (United States)

    Diehl, Tobias; Singer, Julia; Hetényi, György; Grujic, Djordje; Clinton, John; Giardini, Domenico; Kissling, Edi; Gansser Working Group


    The instrumental record of Bhutan is characterized by a lower seismicity compared to other parts of the Himalayan arc. To understand this low activity and its impact on the seismic hazard, a seismic network was installed in Bhutan for 22 months between 2013 and 2014. Recorded seismicity, earthquake moment tensors and local earthquake tomography reveal along-strike variations in structure and crustal deformation regime. A thickened crust imaged in western Bhutan suggests lateral differences in stresses on the Main Himalayan Thrust (MHT), potentially affecting the interseismic coupling and deformation regime. Sikkim, western Bhutan and its foreland are characterized by strike-slip faulting in the Indian basement. Strain is particularly localized along a NW-SE striking mid-crustal fault zone reaching from Chungthang in northeast Sikkim to Dhubri at the northwestern edge of the Shillong Plateau in the foreland. The dextral Dhubri-Chungthang fault zone (DCF) causes segmentation of the Indian basement and the MHT between eastern Nepal and western Bhutan and connects the deformation front of the Himalaya with the Shillong Plateau by forming the western boundary of the Shillong block. The Kopili fault, the proposed eastern boundary of this block, appears to be a diffuse zone of mid-crustal seismicity in the foreland. In eastern Bhutan we image a seismogenic, flat portion of the MHT, which might be either related to a partially creeping segment or to increased background seismicity originating from the 2009 MW 6.1 earthquake. In western-central Bhutan clusters of micro-earthquakes at the front of the High-Himalayas indicate the presence of a mid-crustal ramp and stress buildup on a fully coupled MHT. The area bounded by the DCF in the west and the seismogenic MHT in the east has the potential for M7-8 earthquakes in Bhutan. Similarly, the DCF has the potential to host M7 earthquakes as documented by the 2011 Sikkim and the 1930 Dhubri earthquakes, which were potentially

  10. Deformation behavior of migmatites: insights from microstructural analysis of a garnet-sillimanite-mullite-quartz-feldspar-bearing anatectic migmatite at Rampura-Agucha, Aravalli-Delhi Fold Belt, NW India (United States)

    Prakash, Abhishek; Piazolo, Sandra; Saha, Lopamudra; Bhattacharya, Abhijit; Pal, Durgesh Kumar; Sarkar, Saheli


    In the present study we investigate the microstructural development in mullite, quartz and garnet in an anatectic migmatite hosted within a Grenvillian-age shear zone in the Aravalli-Delhi Fold Belt. The migmatite exhibits three main deformation structures and fabrics (S1, S2, S3). Elongated garnet porphyroblasts are aligned parallel to the metatexite S2 layers and contain crenulation hinges defined by biotite-sillimanite-mullite-quartz (with S1 axial planar foliation). Microstructural evidence and phase equilibrium relations establish the garnet as a peritectic phase of incongruent melting by breakdown of biotite, sillimanite ± mullite and quartz at peak P-T of 8 kbar, 730 °C along a tight-loop, clockwise P-T path. Monazite dating establishes that the partial melting occurred between 1000 and 870 Ma. The absence of subgrains and systematic crystal lattice distortions in these garnets despite their elongation suggests growth pseudomorphing pre-existing 3-D networks of S1 biotite aggregates rather than high-temperature crystal plastic deformation which is noted in the S1 quartz grains that exhibit strong crystallographic preferred orientation (CPO), undulatory extinction and subgrains. Mode-I fractures in these garnet porphyroblasts induced by high melt pressure during late stage of partial melt crystallization are filled by retrograde biotite-sillimanite. Weak CPO and non-systematic crystal lattice distortions in the coarse quartz grains within the S2 leucosome domains indicate these crystallized during melt solidification without later crystal plastic deformation overprint. In the later stages of deformation (D3), strain was mostly accommodated in the mullite-biotite-sillimanite-rich restite domains forming S3 which warps around garnet and leucosome domains; consequently, fine-grained S3 quartz does not exhibit strong CPOs.

  11. Structure and structural evolution of the Rechnitz window and adjacent units, Eastern Alps: changing Neogene extension directions due to motion around a foreland promontory (United States)

    Neubauer, Franz; Cao, Shuyun


    The Rechnitz window is part of Penninic window group exposed along the South Burgenland basement high within the large Neogene Pannonian basin, which is formed by changing the extension directions during the motion of the Alcapa block around the Bohemian foreland promontory. Based on new data of the structural history of Penninic units, its burial and exhumation is proposed during eastward and northeastward motion around the Bohemian foreland promontory. Two tectonic units within the Rechnitz window are distinguished, the Schlaining unit with ophiolites, which show a Paleogene history of subduction (deformation stage D1), and the Köszeg unit with distal continental margin successions indicated by their richness of continent-derived clastic material. Previous fossil findings indicate a persistence of sedimentation until early Late Cretaceous. Both units were subducted during Paleogene and suffered blueschist metamorphism. The age of ophiolite obduction onto the Köszeg unit must be between latest Paleocene and earliest Miocene associated with peak temperature conditions (deformation stage D2, likely at 22 Ma). A new 40Ar/39Ar white mica age shows a plateau-type pattern at 22.3 ± 0.2 Ma and a subsequent thermal event of Ar loss at 19.2 ± 0.5 Ma. Exhumation and extension of buried Penninic rocks were facilitated by a sequence of normal faults and the change of the motion direction from northeastward to eastward motion (D3 and D4a). In present-day coordinates, the initial stage of faulting along a major ductile low-angle normal fault was directed northeastward at ca. 19 Ma. In the subsequent stage (Early Miocene), extension resulted in a ca. eastward prograding rolling hinge, which separates the Rechnitz window from Danube basin located in the east (D4a). Gently W-dipping thrust faults indicate ca. WSW-ENE shortening and also resulted in ca. N-S trending E-vergent folds occur in lower sectors of the Köszeg unit (deformation stage D4b). Finally, small Late Miocene

  12. Regional deformation of late Quaternary fluvial sediments in the Apennines foreland basin (Emilia, Italy) (United States)

    Stefani, Marco; Minarelli, Luca; Fontana, Alessandro; Hajdas, Irka


    Our research is aimed at estimating the vertical deformation affecting late Quaternary units accumulated into the foreland basin of the Northern Apennines chain. Beneath the study alluvial plain, compressive fault-fold structures are seismically active. We reconstructed the stratigraphic architecture and the depositional evolution of the alluvial deposits, which accumulated in the first 40 m of subsurface, through the last 45,000 years, from before the Last Glacial Maximum to the present. A 58 km-long stratigraphic profile was correlated from the foothill belt near Bologna to the vicinity of the Po River. The analysis of the profile documents subsidence movements through the last 12,000 years, exceeding - 18 m in syncline areas, with subsidence rates of at least 1.5 m/ka. Anticlines areas experienced a much lower subsidence than the syncline ones.

  13. Structuring and evolution of Neogene transcurrent basins in the Tellian foreland domain, north-eastern Tunisia (United States)

    Melki, Fetheddine; Zouaghi, Taher; Harrab, Salah; Sainz, Antonio Casas; Bédir, Mourad; Zargouni, Fouad


    The Neogene sedimentary basins (Serravallian to Quaternary) of the Tellian tectonic foreland in north-eastern Tunisia formed within the overall NE-SW sinistral strike-slip tectonic framework of the Ras El Korane-Thibar and El Alia-Teboursouk fault systems. From stratigraphic logs, structural cross sections and interpretation of 2D seismic lines and boreholes, the pre-Neogene basement can be interpreted to be structured according to Eocene (NW-SE) compressional and Oligocene extensional phases. This basement comprises structural highs (anticlines and horsts) and subsiding areas (synclines, half-grabens and grabens) formed during the Neogene. The subsiding areas are delineated by faults striking N030E, N-S and N140E, defining (i) narrow, strongly subsiding synclines, (ii) lozenge-shaped basins and (iii) trapezoidal basins. The architecture of their fill results from the sedimentary balance between tectonics and eustatism. Halokinesis and clay diapirism (driven by Triassic and Neogene evaporites and clays) also played an important role in basin evolution, contributing to the formation of domes and diapirs along active faults.

  14. Climate warming could increase recruitment success in glacier foreland plants. (United States)

    Mondoni, Andrea; Pedrini, Simone; Bernareggi, Giulietta; Rossi, Graziano; Abeli, Thomas; Probert, Robin J; Ghitti, Michele; Bonomi, Costantino; Orsenigo, Simone


    Glacier foreland plants are highly threatened by global warming. Regeneration from seeds on deglaciated terrain will be crucial for successful migration and survival of these species, and hence a better understanding of the impacts of climate change on seedling recruitment is urgently needed to predict future plant persistence in these environments. This study presents the first field evidence of the impact of climate change on recruitment success of glacier foreland plants. Seeds of eight foreland species were sown on a foreland site at 2500 m a.s.l., and at a site 400 m lower in altitude to simulate a 2·7 °C increase in mean annual temperature. Soil from the site of origin was used to reproduce the natural germination substrate. Recruitment success, temperature and water potential were monitored for 2 years. The response of seed germination to warming was further investigated in the laboratory. At the glacier foreland site, seedling emergence was low (0 to approx. 40 %) and occurred in summer in all species after seeds had experienced autumn and winter seasons. However, at the warmer site there was a shift from summer to autumn emergence in two species and a significant increase of summer emergence (13-35 % higher) in all species except two. Survival and establishment was possible for 60-75 % of autumn-emerged seedlings and was generally greater under warmer conditions. Early snowmelt in spring caused the main ecological factors enhancing the recruitment success. The results suggest that warming will influence the recruitment of glacier foreland species primarily via the extension of the snow-free period in spring, which increases seedling establishment and results in a greater resistance to summer drought and winter extremes. The changes in recruitment success observed here imply that range shifts or changes in abundance are possible in a future warmer climate, but overall success may be dependent on interactions with shifts in other components of the

  15. Deformation and kinematics of the central Kirthar Fold Belt, Pakistan (United States)

    Hinsch, Ralph; Hagedorn, Peter; Asmar, Chloé; Nasim, Muhammad; Aamir Rasheed, Muhammad; Kiely, James M.


    The Kirthar Fold Belt is part of the lateral mountain belts in Pakistan linking the Himalaya orogeny with the Makran accretionary wedge. This region is deforming very oblique/nearly parallel to the regional plate motion vector. The study area is situated between the prominent Chaman strike-slip fault in the West and the un-deformed foreland (Kirthar Foredeep/Middle Indus Basin) in the East. The Kirthar Fold Belt is subdivided into several crustal blocks/units based on structural orientation and deformation style (e.g. Kallat, Khuzdar, frontal Kirthar). This study uses newly acquired and depth-migrated 2D seismic lines, surface geology observations and Google Earth assessments to construct three balanced cross sections for the frontal part of the fold belt. Further work was done in order to insure the coherency of the built cross-sections by taking a closer look at the regional context inferred from published data, simple analogue modelling, and constructed regional sketch sections. The Khuzdar area and the frontal Kirthar Fold Belt are dominated by folding. Large thrusts with major stratigraphic repetitions are not observed. Furthermore, strike-slip faults in the Khuzdar area are scarce and not observed in the frontal Kirthar Fold Belt. The regional structural elevation rises from the foreland across the Kirthar Fold Belt towards the hinterland (Khuzdar area). These observations indicate that basement-involved deformation is present at depth. The domination of folding indicates a weak decollement below the folds (soft-linked deformation). The fold pattern in the Khuzdar area is complex, whereas the large folds of the central Kirthar Fold Belt trend SSW-NNE to N-S and are best described as large detachment folds that have been slightly uplifted by basement involved transpressive deformation underneath. Towards the foreland, the deformation is apparently more hard-linked and involves fault-propagation folding and a small triangle zone in Cretaceous sediments

  16. Lateral variations in foreland flexure of a rifted continental margin: The Aquitaine Basin (SW France) (United States)

    Angrand, P.; Ford, M.; Watts, A. B.


    We study the effects of the inherited Aptian to Cenomanian rift on crustal rheology and evolution of the Late Cretaceous to Neogene flexural Aquitaine foreland basin, northern Pyrenees. We use surface and subsurface geological data to define the crustal geometry and the post-rift thermal subsidence, and Bouguer gravity anomalies and flexural modeling to study the lateral variation of the elastic thickness, flexure of the European plate and controlling loads. The Aquitaine foreland can be divided along-strike into three sectors. The eastern foreland is un-rifted and is associated with a simple flexural subsidence. The central sector is affected by crustal stretching and the observed foreland base is modeled by combining topographic and buried loads, with post-rift thermal subsidence. In the western sector the foreland basin geometry is mainly controlled by post-rift thermal subsidence. These three sectors are separated by major lineaments, which affect both crustal and foreland geometry. These lineaments seem to be part of a larger structural pattern that includes the Toulouse and Pamplona Faults. The European foreland shows lateral variations in flexural behavior: the relative role of surface and sub-surface (i.e., buried) loading varies along-strike and the elastic thickness values decrease from the north-east to the south-west where the plate is the most stretched. We suggest that foreland basins are influenced by the thermal state of the underlying lithosphere if it was initiated soon after rifting and that thermal cooling can contribute significantly to subsidence.

  17. Characterization of a petroleum system in the Himalayan foreland basin

    Energy Technology Data Exchange (ETDEWEB)

    Sorkhabi, R. [Japan National Oil Corp., Tokyo (Japan)


    The Himalayan foreland basin that is a part of the Tethyan tectonic belt is a potential target for hydrocarbon exploration. Petroleum has been yield in the west part of basin (Pakistan), and in the east part (Myanmar). This study takes aim to the central parts of the Himalayan foreland basin (India and Nepal), and identifies sediments Paleocene in age (the Subathu Formation made up of limestone and shale, and Murree Group made up of mudstone and shale) as source rock (TOC content up to 0.5 %), and also identifies permeable Siwalik sandstone (Paleocene-Middle to Neogene) as reservoir rock (porosity ranges from 4 to 27%, and permeability ranges from 0.1 to 10 millidarcy). Source rock had been occurred thermal maturity by burial in late Miocene. The serious problem is the localization of seals and traps. It indicates a potentiality that suitable trap structures had been formed by Main Boundary Thrust (MBT), close to Lesser Himalaya, lifting up and transporting the Proterozoic shale and carbonate rocks atop the Siwalik sandstone. The overthrust activities of source rock (Subathu-Murree Group) atop the Siwalik are important for formation of seals and traps. Actuary, gas and oil seeps are found not in Tarai (plain) but in the vicinity of the MBT. (translated by NEDO)

  18. The occurrence and origin of celestite in the Abolfares region, Iran: Implications for Sr-mineralization in Zagros fold belt (ZFB) (United States)

    Pourkaseb, Houshang; Zarasvandi, Alireza; Rezaei, Mohsen; Mahdavi, Reyhaneh; Ghanavati, Fatemeh


    The major celestite deposits in Zagros Fold belt are associated with coastal marine carbonate and evaporate sediments of Oligo-Miocene Asmari and Lower Miocene Ghachsaran Formations. In the Abolfares region, celestite mineralization is extended in the western limb of Bangestan anticline in the carbonates of Early Miocene (middle part of Asmari Formation), underlying by dolomitic carbonates of Burdigalian. From bottom to top three main types of mineralization can be distinguished in the study area: (1) layer texture resulting from replacement of algal limestone by celestite minerals with some parts showing idiomorphic crystals (geodes) along the walls of the cavities, (2) celestite occurrence as irregular massive shape interconnected small crystals and nodules, and (3) celestite mineralization associated with steeply dipping veins and open space fracture fillings, resulting from late-stage epigenetic processes. Highlightly, the ore-hosting carbonate rocks were deposited in an intertidal - supratidal protected setting with hypersaline conditions, in accordance with other celestite deposits of the Zagros Fold belt. The abundance of diagenetic crystallization rhythmites, carbonate and anhydrite inclusions as confirmed by Laser Raman spectroscopy analysis, high Sr/Ba values (average; 8726.1) and strong negative correlations between SO3 vs CaO (R2 = 0.98), SrO vs CaO (R2 = 0.96) with positive correlations between Ba vs SrO (R2 = 0.54) and SO3 vs SrO (R2 = 0.98) highlight the role of high Sr late-diagenetic brines in replacement of carbonates with celestite minerals. It seems that the inception of compressional folding during or soon after the deposition of the Asmari Formation in the carbonate platform at the margin of NW-trending basin in the foreland of the Zagros orogenic belt lead to the upward refluxing of penetrated high-Sr diagenetic brines and celestite mineralization.

  19. 2D Seismic Velocity Modelling in the Southeastern Romanian Carpathians and its Foreland (Vrancea Zone and Focsani Basin) (United States)

    Stephenson, R.; Bocin, A.; Tryggvason, A.


    The DACIA-PLAN (Danube and Carpathian Integrated Action on Processes in the Lithosphere and Neotectonics) deep seismic reflection survey was performed in August-September 2001, with the objective of obtaining of new information on the deep structure of the external Carpathians nappes and the architecture of Tertiary/Quaternary basins developed within and adjacent to the seismically-active Vrancea Zone, including the rapidly subsiding Focsani Basin. The DACIA-PLAN profile is about 140 km long, having a roughly NW-SE direction, from near the southeast Transylvanian Basin, across the mountainous southeastern Carpathians and their foreland to near the Danube Dalta. A high resolution 2D velocity model of the upper crust along the seismic profile has been determined from a first-arrival tomographic inversion of the DACIA-PLAN data. The shallowing of Palaeozoic-Mesozoic basement, and related structural heterogeneity within it, beneath the eastern flank of the Focsani Basin is clearly seen. Velocity heterogeneity within the Carpathian nappe belt is also evident and is indicative of internal structural complexity, including the presence of salt bodies and basement involvement in thrusting, thus favouring some current geological models over others. The presence of basement involvement implies the compressional reactivation of pre-existing basement normal faults. Members of the DACIA-PLAN/TomoSeis Working Group (see poster) should be considered as co-authors of this presentation.

  20. Age and origin of coeval TTG, I- and S-type granites in the Famatinian belt of NW Argentina

    International Nuclear Information System (INIS)

    Rapela, C.W.


    Full text: Located on the Palaeozoic Pacific margin of Gondwana, at the opposite extreme to the Lachlan Fold Belt, the Sierras Pampeanas of central and NW Argentina also constitute a large granitic province displaying the coeval concurrence of I and S-type magmas. The Famatinian magmatic belt consists mostly of granitoids emplaced in Early Ordovician times, after Cambrian accretion of the Pampean terrane and before the Late Ordovician/Silurian accretion of the Precordillera terrane. New SHRIMP U-Pb zircon ages, isotope and geochemical data are used to interpret the petrogenesis of this belt. Three types of granitoid are recognized in the Famatinian belt, based on lithology and geochemical data. These are (a) a minor trondhjemite-tonalite-granodiorite (TTG) group, which occurs only in the Pampean foreland, (b) a metaluminous I-type gabbromonzogranite suite, and (c) S-type granites, which occur both as small cordieritic intrusions associated with l-type granodiorites and as large batholithic masses. Twelve new SHRIMP U-Pb zircon ages establish the contemporaneity of all three types in Early Ordovician times (mainly 470-490 Ma ago). Sr- and Nd-isotopic data suggest that, apart from some TTG plutons with asthenospheric characteristics, the remaining magmas were derived from a Proterozoic crust-lithospheric mantle section (Nd model ages of 1500-1700 Ma). Granulite xenoliths in Cretaceous alkalic rocks that have been described by other authors may represent samples of this source region. Trace element modelling suggests that the TTG and I-type gabbros originated by variable melting of a lithospheric gabbroid source at 10-12 kbar and ca. 5 kbar, respectively. The voluminous intermediate and acidic I-types, which show a trend to slightly more evolved isotopic signatures than the inferred source, probably represent hybridization of the most primitive magmas with lower and middle crustal melts. The highly peraluminous S-type granites have similar isotopic and inherited

  1. Better Buildings NW Ohio

    Energy Technology Data Exchange (ETDEWEB)

    Moyer, Kevin [Toledo-Lucas County Port Authority, Toledo, OH (United States)


    Districts or ESIDs and what is nationally known as Property Assessed Clean Energy or PACE districts and PACE financing. The project methodology followed the identify, develop, implement, monitor and measure format. These districts began in Toledo and adjoining areas and are expanding to TLCPA’s 28 county financing agency geographic footprint. What began as the Toledo Ohio Advanced Energy Improvement Corporation is now doing business as the Northwest Ohio Advanced Energy Improvement District recognizing it expansion into creating and financing other districts in NW Ohio. The program has been sought out as an advisor by major communities and states in the process of developing similar legislation and programs and has become one of the largest most successful PACE energy improvement and financing districts in the US. The program and the energy district focused on transforming energy use, delivery, conservation and renewable energy as “options of first choice”. The significant energy savings paid for many of the improvements and created a financially viable program well beyond the grant period. The program has become a model within the State of Ohio and Nationally on how to implement and finance projects in broad energy districts including how to evolve and integrate several financing methodologies. It is a unique utilization of revolving loan funds and energy bond pooling with revenue backing primarily from energy improvement special assessments on commercial properties along with some power purchase agreement (PPA) and loan agreement revenue. The program has also incorporated Qualified Energy Conservation Bonds, State of Ohio Energy Loans (SEP), utility rebates, solar and renewable energy certificates, renewable tax incentives and grants, and owner funded equity as additional program leverage and funding. Other keys to this success have been a continual simplification and refinement of the application and documentation process to make funding available easily and

  2. Timing and mechanism of the rise of the Shillong Plateau in the Himalayan foreland.


    Govin, Gwladys; Najman, Yanina Manya Rachel; Copley, Alex; Millar, Ian; Van der Beek, Peter; Huyghe, Pascale; Grujic, Djordje; Davenport, Jesse


    The Shillong Plateau (northeastern India) constitutes the only significant topography in the Himalayan foreland. Knowledge of its surface uplift history is key to understanding topographic development and unraveling tectonic–climate–topographic coupling in the eastern Himalaya. We use the sedimentary record of the Himalayan foreland basin north of the Shillong Plateau to show that the paleo-Brahmaputra river was redirected north and west by the rising plateau at 5.2–4.9 Ma. We suggest that on...

  3. An Andean-type retro-arc foreland system beneath northwest South China revealed by SINOPROBE profiling (United States)

    Li, Jianhua; Dong, Shuwen; Cawood, Peter A.; Zhao, Guochun; Johnston, Stephen T.; Zhang, Yueqiao; Xin, Yujia


    In the Mesozoic, South China was situated along the convergent margin between the Asian and Pacific plates, providing an excellent laboratory to understand the interactions between deformation, sedimentation and magmatism in a retroarc environment. The crustal architecture of northwest South China is displayed along the ∼600-km-long SINOPROBE deep seismic reflection profiles and reveals from east to west: (1) highly folded and truncated reflectors in the upper crust of the Yangtze Fold Zone, which correspond to thin- and thick-skinned thrust systems, and document large-scale intraplate structural imbrication and shortening; (2) a crustal-scale flat-ramp-flat structure, termed the Main Yangtze decollement, which forms a weak, viscous layer to accommodate strain decoupling and material transport in the thin- and thick-skinned systems; and (3) nearly flat-lying reflectors in the Sichuan Basin, which support interpretation of the basin as a weakly deformed depocentre. The Yangtze Fold Zone and the Sichuan Basin represent a retro-arc foreland basin system that is >800 km away from the continental-margin magmatic arc. We suggest that tectonic processes across the arc and retro-arc systems, including arc magma flare-up, basin sedimentation, retroarc thrust propagation, lithosphere underthrusting, root foundering, and extension-related magmatism were interrelated and governed mass transfer. Age data and geological relations link the tectonic processes to evolving geodynamics of the subducting Paleo-Pacific plate.

  4. Revised crustal architecture of the southeastern Carpathian foreland from active and passive seismic data (United States)

    Enciu, Dana M.; Knapp, Camelia C.; Knapp, James H.


    Integration of active and passive source seismic data is employed in order to study the nature of the relationships between crustal seismicity and geologic structures in the southeastern (SE) Carpathian foreland of Romania and the possible connection with the Vrancea Seismogenic Zone (VSZ) of intermediate-depth seismicity, one of the most active earthquake-prone areas in Europe. Crustal epicenters and focal mechanisms are correlated with four deep industry seismic profiles, the reprocessed Danube and Carpathian Integrated Action on Process in the Lithosphere and Neotectonics (DACIA PLAN) profile and the Deep Reflection Acquisition Constraining Unusual Lithospheric Activity II and III (DRACULA) profiles in order to understand the link between neotectonic foreland deformation and Vrancea mantle seismicity. Projection of crustal foreland hypocenters onto deep seismic profiles identifies several active crustal faults in the SE Carpathian foreland and suggests a mechanical coupling between the mantle located VSZ and the overlying foreland crust. The coupled associated deformation appears to take place on the Trotus Fault, the Sinaia Fault, and the newly detected Ialomita Fault. Seismic reflection imaging reveals the absence of west dipping reflectors in the crystalline crust and a slightly east dipping to horizontal Moho in the proximity of the Vrancea area. These findings argue against previously purported mechanisms to generate mantle seismicity in the VSZ including oceanic lithosphere subduction in place and oceanic slab break off, furthermore suggesting that the Vrancea seismogenic body is undetached from the overlying crust in the foreland.

  5. The Tunas Formation (Permian) in the Sierras Australes foldbelt, east central Argentina: evidence for syntectonic sedimentation in a foreland basin (United States)

    Lopez-Gamundi, O. R.; Conaghan, P. J.; Rossello, E. A.; Cobbold, P. R.


    The Tunas Formation, extensively exposed in the Sierras Australes foldbelt of eastern central Argentina, completes the sedimentation of the Gondwanan (Late Carboniferous-Permian) sequence, locally known as the Pillahuincó Group. The underlying units of the Group show an integrated depositional history which can be explained in terms of glaciomarine sedimentation (Sauce Grande Formation) and postglacial transgression (Piedra Azul and Bonete Formations). This succession also has a rather uniform quartz-rich, sand-sized composition indicative of a cratonic provenance from the Tandilia Massif to the northeast. Early to Late Permian deformation folded and thrusted the southwestern basin margin (Sierras Australes) and triggered the deposition of a 1,500 m — thick, synorogenic prograding wedge, the Tunas Formation, in the adjacent foreland basin (Sauce Grande or Claromecó Basin). Sandstone detrital modes for the Tunas deposits show moderate to low contents of quartz and abundant lithics, mostly of volcanic and metasedimentary origin. Paleocurrents are consistently from the SW. Tuffs interbedded with sandstones in the upper half of Tunas Formation (Early — early Late? Permian) are interpreted as being derived from volcanic glass-rich tuffs settled in a body of water. Extensive rhyolitic ignimbrites and consanguineous airborne tuffaceous material erupted in the northern Patagonian region during that period. The age constraints and similarities in composition between these volcanics and the tuffaceous horizons present in the Sauce Grande, Parana and Karoo Basins suggest a genetic linkage between these two episodes. The intimate relationship between volcanic activity inboard of the paleo-Pacific margin, deformation in the adjacent orogenic belt and subsidence and sedimentation in the contiguous foreland basin constitutes a common motif in the Sauce Grande and Karoo Basins of southwestern Gondwana.

  6. U-Pb geochronology of modern river sands from the flat-slab segment of the southern central Andes, Argentina, 29-31°S: Implications for Neogene foreland and hinterland basin evolution (United States)

    Capaldi, T.; Horton, B. K.; McKenzie, R.; Stockli, D. F.


    This study investigates how Andean river sediments in the flat-slab segment of western Argentina record active mixing of lithologically and geochemically distinct source regions comprising the Principal Cordillera, Frontal Cordillera, Precordillera fold-thrust belt, Sierras Pampeanas basement uplifts, and recycled Neogene basin fill. Detrital zircon U-Pb geochronological results for modern river sands discriminate variations from hinterland source regions, through river tributaries and main trunks of the Bermejo, Jachal, San Juan, and Mendoza rivers, and their respective fluvial megafans within the active foreland basin. Proportions of proximal zircon populations in the hinterland trunk rivers (with extensive Permian-Triassic and Cenozoic igneous exposures) diminish downstream with progressive contributions from the frontal Precordillera fold-thrust belt (dominantly Paleozoic sedimentary rocks) and Pampean basement uplifts. However, this systematic downstream dilution is perturbed in several catchments by significant recycling of older foreland basin fill. The degree of recycling depends on the position and extent of Oligocene-Pliocene exposures within the catchments. To discern the effects of the variable detrital zircon sources, multiple statistical methods are utilized. Quantitative comparisons suggest that variations in detrital zircon age distributions among the modern sands, and with older foreland basin fill and exposed bedrock, are dependent on spatial and temporal variations in exhumation and drainage network evolution within their respective Andean catchments. The present surface area of competing source regions and the configuration of hinterland tributary rivers largely dictate the degree of downstream dilution and/or recycling. This study provides a modern analogue and baseline for reconstructing Neogene shifts in foreland basin provenance, depositional systems, and drainage configurations during a critical transition to flat-slab subduction.

  7. Influence of inherited structures on the growth of basement-cored ranges, basin inversion and foreland basin development in the Central Andes, from apatite fission-track and apatite Helium thermochronology. (United States)

    Zapata, S.; Sobel, E. R.; Del Papa, C.; Jelinek, A. R.; Muruaga, C.


    The Central Andes in NW of Argentina is part of a long-lived subduction zone, active since the Paleozoic. This region experienced several tectonic cycles; each of which created an unique set of structures and may have reactivated preexisting structures. These inherited structures may exert a first-order control over the different foreland deformational styles observed along the strike in the Central Andes. Our study area is located between 26°S and 28°S on the transition between the broken foreland (Santa Barbara system), which expresses a combination of thin-skin and thick-skin styles, and the Sierras Pampeanas, which is deform in a thick-skin style. The Cumbres Calchaquies range and the associated Choromoro Basin are located in the northern part of the study area, and are the southern expression of the Santa Barbara system. Published thermochronology data suggest that the rocks from the basement experienced Late Cretaceous and Late Miocene exhumation; the associated sedimentary rocks within the Choromoro basin experienced Paleogene and Late Miocene deformational phases. In contrast, the Sierra Aconquija range, located immediately south on the transition to the Sierras Pampeanas (thick skin) foreland basin, exhibit larger amounts of Miocene exhumation and lack of Cretaceous exhumation; the associated sedimentary rocks from the Tucuman basin have not been deformed since the Cretaceous. Our goal is to understand the evolution of the structural blocks and the structures responsible for the along strike changes in foreland basin deformational styles and their relation with inherited structures from previous tectonic cycles. We are obtaining new apatite U-Th/He and fission track data to reconstruct the thermal history of the basement, accompanied by U-Pb geochronology and stratigraphy to constrain the evolution of the associated sedimentary basins. Preliminary results combined with published data suggest that inherited structures within the study area have evolved

  8. Vocal Fold Paralysis (United States)

    ... here Home » Health Info » Voice, Speech, and Language Vocal Fold Paralysis On this page: What is vocal fold ... Where can I get additional information? What is vocal fold paralysis? Structures involved in speech and voice production ...

  9. Cenozoic sedimentation and exhumation of the foreland basin system preserved in the Precordillera thrust belt (31-32°S), southern central Andes, Argentina (United States)

    Levina, Mariya; Horton, Brian K.; Fuentes, Facundo; Stockli, Daniel F.


    Andean retroarc compression associated with subduction and shallowing of the oceanic Nazca plate resulted in thin-skinned thrusting that partitioned and uplifted Cenozoic foreland basin fill in the Precordillera of west-central Argentina. Evolution of the central segment of the Precordillera fold-thrust belt is informed by new analyses of clastic nonmarine deposits now preserved in three intermontane regions between major east directed thrust faults. We focus on uppermost Oligocene-Miocene basin fill in the axial to frontal Precordillera at 31-32°S along the Río San Juan (Albarracín and Pachaco sections) and the flank of one of the leading thrust structures (Talacasto section). The three successions record hinterland construction of the Frontal Cordillera, regional arc volcanism, and initial exhumation of Precordillera thrust sheets. Provenance changes recorded by detrital zircon U-Pb age populations suggest that initial shortening in the Frontal Cordillera coincided with an early Miocene shift from eolian to fluvial accumulation in the adjacent foreland basin. Upward coarsening of fluvial deposits and increased proportions of Paleozoic clasts reflect cratonward (eastward) advance of deformation into the Precordillera and resultant structural fragmentation of the foreland basin into isolated intermontane segments. Apatite (U-Th)/He thermochronometry of basin fill constrains to 12-9 Ma the most probable age of uplift-induced exhumation and cooling of Precordillera thrust sheets. This apparent pulse of exhumation is evident in each succession, suggestive of rapid, large-scale exhumation by synchronous thrusting above a single décollement linking major structures of the Precordillera.

  10. Thermal evidence of Caledonide foreland, molasse sedimentation in Fennoscandia

    Energy Technology Data Exchange (ETDEWEB)

    Tullborg, E L; Larsson, S Aa; Bjoerklund, L; Stigh, J [Goeteborg Univ. (Sweden). Dept. of Geology, Earth Sciences Centre; Samuelsson, L [Geological Survey of Sweden, Goeteborg (Sweden). Earth Sciences Centre


    The Phanerozoic rocks present on the Fennoscandian Shield are dominantly of Cambrian to Silurian age. They represent a relatively thin sedimentary cover. The question is: why do we not see any remnants of younger sedimentary rocks? Did they ever exist, have they been eroded, transported and redeposited elsewhere? {delta}{sup 18}O and {delta}{sup 13}C analyses of Ordovician limestones from different places in Sweden and from the Oslo region in Norway show modification of their original marine signature according to the {delta}{sup 18}O concentrations, while the {delta}{sup 13}C concentrations generally are typical for marine limestones. In some cases the modifications can be explained by intrusions of dykes or by metamorphic events, but in most areas the redistribution of the oxygen isotopes indicates burial diagenesis. From a number of published investigations, raised temperatures at the present surface during the late Palaeozoic, are indicated by different temperature indicators. We suggest that these increased temperatures were due to a sedimentary cover of mainly Devonian sediments deposited on top of the Cambrian-Silurian sequence. This palaeo-cover caused raised temperatures at the present rock surface. In the Proterozoic basement, annealing of fission tracks in apatite and mobility of radiogenic lead also give evidence of increased temperatures. A model where the thickness of the Upper Paleozoic cover of the Caledonian foreland is 2-4 kilometers thick is suggested. This cover mainly consisted of late Silurian-Devonian erosion products from the Caledonides, the latter formed during a Silurian continent-continent collision. A major Permian to Triassic uplift and erosion reduced the cover significantly. 94 refs, 9 figs.

  11. Flips for 3-folds and 4-folds

    CERN Document Server

    Corti, Alessio


    This edited collection of chapters, authored by leading experts, provides a complete and essentially self-contained construction of 3-fold and 4-fold klt flips. A large part of the text is a digest of Shokurov's work in the field and a concise, complete and pedagogical proof of the existence of 3-fold flips is presented. The text includes a ten page glossary and is accessible to students and researchers in algebraic geometry.

  12. Coastal evolution of a cuspate foreland (Flakket, Anholt, Denmark) between 2006 and 2010

    DEFF Research Database (Denmark)

    Clemmensen, Lars B; Bendixen, Mette; Nielsen, Lars


    Flakket is a cuspate marine foreland on the north coast of Anholt in the Kattegat sea. It is composed of a number of gravel-rich beach ridges typically covered by aeolian sand and intervening swales and wetlands including a relatively large lagoon. The most recent evolution of the coastline...... of this marine foreland between May 2006 and September 2010 is documented in this paper. Flakket is under erosion on its northwestern side, which has retreated up to 40 m during the observation period. The shoreline of the northeastern side of the beach-ridge plain moved up to 70 m in a seaward direction during...

  13. Early Cretaceous overprinting of the Mesozoic Daqing Shan fold-and-thrust belt by the Hohhot metamorphic core complex, Inner Mongolia, China

    Directory of Open Access Journals (Sweden)

    Gregory A. Davis


    Full Text Available The Early Cretaceous Hohhot metamorphic core complex (mcc of the Daqing Shan (Mtns. of central Inner Mongolia is among the best exposed and most spectacular of the spatially isolated mcc’s that developed within the northern edge of the North China “craton”. All of these mcc’s were formed within the basement of a Late Paleozoic Andean-style arc and across older Mesozoic fold-and-thrust belts of variable age and tectonic vergence. The master Hohhot detachment fault roots southwards within the southern margin of the Daqing Shan for an along-strike distance of at least 120 km. Its geometry in the range to the north is complicated by interference patterns between (1 primary, large-scale NW-SE-trending convex and concave fault corrugations and (2 secondary ENE-WSW-trending antiforms and synforms that folded the detachment in its late kinematic history. As in the Whipple Mtns. of California, the Hohhot master detachment is not of the Wernicke (1981 simple rooted type; instead, it was spawned from a mid-crustal shear zone, the top of which is preserved as a mylonitic front within Carboniferous metasedimentary rocks in its exhumed lower plate. 40Ar–39Ar dating of siliceous volcanic rocks in basal sections of now isolated supradetachment basins suggest that crustal extension began at ca. 127 Ma, although lower-plate mylonitic rocks were not exposed to erosion until after ca. 119 Ma. Essentially synchronous cooling of hornblende, biotite, and muscovite in footwall mylonitic gneisses indicates very rapid exhumation and at ca. 122–120 Ma. Contrary to several recent reports, the master detachment clearly cuts across and dismembers older, north-directed thrust sheets of the Daqing Shan foreland fold-and-thrust belt. Folded and thrust-faulted basalts within its foredeep strata are as young as 132.6 ± 2.4 Ma, thus defining within 5–6 Ma the regional tectonic transition between crustal contraction and profound crustal extension.

  14. Covering folded shapes

    Directory of Open Access Journals (Sweden)

    Oswin Aichholzer


    Full Text Available Can folding a piece of paper flat make it larger? We explore whether a shape S must be scaled to cover a flat-folded copy of itself. We consider both single folds and arbitrary folds (continuous piecewise isometries \\(S\\to\\mathbb{R}^2\\. The underlying problem is motivated by computational origami, and is related to other covering and fixturing problems, such as Lebesgue's universal cover problem and force closure grasps. In addition to considering special shapes (squares, equilateral triangles, polygons and disks, we give upper and lower bounds on scale factors for single folds of convex objects and arbitrary folds of simply connected objects.

  15. Numerical modelling of Quaternary terrace staircase formation in the Ebro foreland basin, southern Pyrenees, NE Iberia

    NARCIS (Netherlands)

    van Balen, R.T.; Stange, K.M.; Cloetingh, S.A.P.L.; Garcia-Castellanos, D.


    The southern foreland basin of the Pyrenees (Ebro basin) is an exorheic drainage basin since Late Miocene times. Remnants of an early exorheic Ebro drainage system are not preserved, but morphology provides evidence for the Pliocene–Quaternary drainage development. The incision history of the Ebro

  16. Quaternary tectonic activity of the Murge area (Apulian foreland -Southern Italy

    Directory of Open Access Journals (Sweden)

    M. Tropeano


    Full Text Available Integration of structural, stratigraphical, and sedimentological data and instrumental records of some recent low-energy seismic events in the Murge area allow us to suggest a new seismotectonic picture of this region, generally considered an aseismic and stable sector of the Apulian foreland.

  17. Modeling the interaction between lithospheric and surface processes in foreland basins

    NARCIS (Netherlands)

    Garcia-Castellanos, D.; Cloetingh, S.


    This chapter reviews a number of key advances in quantitative understanding of foreland basins since the early 1990s, with a focus on the interplay between lithospheric flexure, erosion, and river transport. Flexure can be the result of topographic loading and slab-pull forces, though can also

  18. Deformation style and controlling geodynamic processes at the eastern Guadalquivir foreland basin (Southern Spain) (United States)

    Marín-Lechado, C.; Pedrera, A.; Peláez, J. A.; Ruiz-Constán, A.; González-Ramón, A.; Henares, J.


    The tectonic structure of the Guadalquivir foreland basin becomes complex eastward evolving from a single depocenter to a compartmented basin. The deformation pattern within the eastern Guadalquivir foreland basin has been characterized by combining seismic reflection profiles, boreholes, and structural field data to output a 3-D model. High-dipping NNE-SSW to NE-SW trending normal and reverse fault arrays deform the Variscan basement of the basin. These faults generally affect Tortonian sediments, which show syntectonic features sealed by the latest Miocene units. Curved and S-shaped fault traces are abundant and caused by the linkage of nearby fault segments during lateral fault propagation. Preexisting faults were reactivated either as normal or reverse faults depending on their position within the foreland. At Tortonian time, reverse faults deformed the basin forebulge, while normal faults predominated within the backbulge. Along-strike variation of the Betic foreland basin geometry is supported by an increasing mechanical coupling of the two plates (Alborán Domain and Variscan basement) toward the eastern part of the cordillera. Thus, subduction would have progressed in the western Betics, while it would have failed in the eastern one. There, the initially subducted Iberian paleomargin (Nevado-Filábride Complex) was incorporated into the upper plate promoting the transmission of collision-related compressional stresses into the foreland since the middle Miocene. Nowadays, compression is still active and produces low-magnitude earthquakes likely linked to NNE-SSW to NE-SW preexiting faults reactivated with reverse oblique-slip kinematics. Seismicity is mostly concentrated around fault tips that are frequently curved in overstepping zones.

  19. Seafloor expression and shallow structure of a fold-and-thrust system, Isfjorden, west Spitsbergen

    Directory of Open Access Journals (Sweden)

    Maria Blinova


    Full Text Available A detailed map of the structure of the west Spitsbergen fold-and-thrust belt in the Isfjorden area, Spitsbergen, is presented. The map was constructed from a dense grid of two-dimensional multichannel reflection seismic and bathymetric data. Joint interpretation of two data sets allowed a comparison of tectonic structures detected along the uppermost parts of the seismic sections and those reflected in the morphology of the seafloor. Three major, predominantly north-west–south-east striking faults were identified. The westernmost fault (T1 is a hinterland-directed (most likely out of sequence thrust, while the central and easternmost faults (T2 and T3 are foreland-directed (in-sequence thrusts. The thrusts divide Isfjorden into three subareas. Subarea 1 is bounded by thrust faults T1 and T2 and comprises Tertiary rocks surrounded by Jurassic–Cretaceous strata. The structural signature of Subarea 1 is that of a system of hinterland- and foreland-directed thrust faults, resulting in a seafloor relief characterized by parallel ridges and troughs. Subarea 2 is limited by thrust faults T2 and T3 and shows Jurassic–Cretaceous outcrops on the seafloor. Subarea 3 is situated east of the main thrust fault T3 and mainly involves outcrops of Triassic–Jurassic rocks. Together, Subareas 2 and 3 are dominated by foreland-directed, north-west–south-east and NNW–SSE-striking thrusts that are hardly detectable in bathymetric data.

  20. Some regularities in the distribution of kenophytes in the Polish Carpathians and their foreland

    Directory of Open Access Journals (Sweden)

    Zając Maria


    Full Text Available The Polish Carpathians and their northern foreland are a rewarding object for the kenophyte distribution research. The study, using the cartogram method, showed that the number of kenophyte species decreases with increasing altitude. Only few kenophytes were found in the lower forest zone. This regularity concerns also the species that reach higher altitudes in the mountains of their native lands. A number of species migrated into the Carpathians through rivers and streams. River valleys generate many open habitats, which are easily colonized by kenophytes due to the lack of competition. In the Carpathians, towns used to be founded in the mountain valleys and this was also a favouring factor of kenophyte propagation. The arrangement of mountain ranges in the Polish Carpathians, including their foreland, hindered the migration of some species and allowed to discover the possible migration routes into the area covered by research. Tracing these migration routes was possible only for those species that have not occupied the whole available area yet. Additionally, the study indicated the most dangerous invasive species in the Polish Carpathians and their foreland.


    Directory of Open Access Journals (Sweden)



    Full Text Available The Guadalquivir foreland basin, located between the Iberian basement northward and the Betic orogen to the South, represents the western sector of the earlier foredeep basin of the Betic Cordillera. Along the northern foreland margin, the sedimentary fill of this basin includes a Tortonian Basal Transgressive Complex (BTC, composed of five internal sequences bounded by transgressive surfaces. Two main parts are distinguished within each sequence: the lower transgressive lag deposits, and the upper stillstand/prograding sediments. Three facies associations were distinguished within this stratigraphic succession along the central sector of this basin margin: unfossiliferous conglomerates and coarse-grained sands (A, fossiliferous conglomerates and coarse-grained sands (B, and yellow medium-coarse-grained fossiliferous sands (C. A fourth facies association (D: blue silty marlstones and shales overlies the BTC. Deposits of alluvial sediments (facies association A and shallow-marine/foreshore sediments (facies association C, were recurrently interrupted by transgressive pulses (facies associations B and C. Every pulse is recorded by an erosional, cemented sandy-conglomerate bar with bivalves (Ostreidae, Isognomon, balanids, gastropods and other marine bioclasts; or their transgressive equivalents. The lateral facies changes in each individual sequence of the BTC are related to: (1 the influence on the northern foreland margin of the tectonic activity of the southern orogenic margin; (2 the palaeorelief formed by irregularities of the substrate which controls the sediment dispersal; and (3 the evolution stages of the sedimentary systems. 

  2. Fluvial-Deltaic Strata as a High-Resolution Recorder of Fold Growth and Fault Slip (United States)

    Anastasio, D. J.; Kodama, K. P.; Pazzaglia, F. P.


    Fluvial-deltaic systems characterize the depositional record of most wedge-top and foreland basins, where the synorogenic stratigraphy responds to interactions between sediment supply driven by tectonic uplift, climate modulated sea level change and erosion rate variability, and fold growth patterns driven by unsteady fault slip. We integrate kinematic models of fault-related folds with growth strata and fluvial terrace records to determine incremental rates of shortening, rock uplift, limb tilting, and fault slip with 104-105 year temporal resolution in the Pyrenees and Apennines. At Pico del Aguila anticline, a transverse dècollement fold along the south Pyrenean mountain front, formation-scale synorogenic deposition and clastic facies patterns in prodeltaic and slope facies reflect tectonic forcing of sediment supply, sea level variability controlling delta front position, and climate modulated changes in terrestrial runoff. Growth geometries record a pinned anticline and migrating syncline hinges during folding above the emerging Guarga thrust sheet. Lithologic and anhysteretic remanent magnetization (ARM) data series from the Eocene Arguis Fm. show cyclicity at Milankovitch frequencies allowing detailed reconstruction of unsteady fold growth. Multiple variations in limb tilting rates from roof ramp and basal dècollement. Along the northern Apennine mountain front, the age and geometry of strath terraces preserved across the Salsomaggiore anticline records the Pleistocene-Recent kinematics of the underlying fault-propagation fold as occurring with a fixed anticline hinge, a rolling syncline hinge, and along-strike variations in uplift and forelimb tilting. The uplifted intersection of terrace deposits documents syncline axial surface migration and underlying fault-tip propagation at a rate of ~1.4 cm/yr since the Middle Pleistocene. Because this record of fault slip coincides with the well-known large amplitude oscillations in global climate that contribute

  3. Kinematics of tectonic fracture development during regional folding in sandstones of the Kamlial Formation, Khushalgarh, northern Pakistan

    International Nuclear Information System (INIS)

    Sayab, M.


    Systematic relationships between the fracture orientation and fold geometry in sedimentary rocks have been used to explain the development of synfolding fractures. Based on field observations at the Khushalgarh syncline, located east of the Kohat Plateau, we proposed that the orientation of fractures was influenced dominantly by two tectonic fracture sets, that is, the NE-SW and NW-SE. The NE-SW fracture set dominantly formed as mode 1 (tensile), where as, the NW-SE fracture set developed as mode 11 (shear) conjugate fractures. The NE-SW trending fractures follow the axis of the syncline, whereas, the NW-SE fracture about crosscuts the fold axis. Most of the NE-SW fractures abut against the NW-SW fracture set. Based on the orientation and crosscutting relationship, their modes in response to stress, we conclude that the NE-SW trending fractures formed early than those of NW-SE fracture set. Though, both the fracture sets are formed during the folding, we suggest that they were not formed at the same time. Their crosscutting relationship suggests that they developed sequentially rather than synchronously. Our interpretations support the laboratory-based models where only one fracture orientation (or set of fractures with one orientation) form in response to single stress. However, as the stress distribution in folded strata changes over time new fractures of distinct orientations can form during or late in the folding history. We conclude that the sandstone units underwent bedding-parallel extension during folding, where bedding is stretched to accommodate extension. Parallel to the fold axis orientation. Bending of the limbs is a likely mechanism for the development of observed NE-SW trending fractures during folding, whereas the NW-SE fractures developed late in the folded history. (author)

  4. Nd, Sr-isotopic provenance and trace element geochemistry of Amazonian foreland basin fluvial sands, Bolivia and Peru: Implications for ensialic Andean orogeny

    International Nuclear Information System (INIS)

    Basu, A.R.; Sharma, M.; DeCelles, P.G.


    Nd and Sr isotopes and the trace element contents, including the rare earths, were determined for fluvial sands of lithic arenite composition from the Madre de Dios foreland basin of Bolivia and Peru. On standard petrologic ternary diagrams, the sands fall in the recycled orogen provenance field and thus are similar to typical ancient foreland basin composition. The average rare earth elemental pattern of the sands is identical to the upper continental crustal average, as estimated from post-Archean composite shales of different continents. Ratio of Th/U, Co/Th, La/Sc and Th/Sc of the fluvial sands are intermediate between an average magmatic arc and an upper crustal average compositions. The dispersion of some trace elemental patterns in the sands can be attributed to fractionation of dense minerals, including zircon, during the sedimentation process. The variations of Nd isotopes in conjunction with the petrographic parameters of lithic metamorphic (Lm) and volcanic (Lv) fragments allow a two-fold classification of the sands. These two sand types can be interpreted in terms of mixing among three different provenances: one volcanic rock-suit with less negative ε Nd (O) parameter than the other volcanic suite, and a third metasedimentary source with ε Nd (O) value of around -12, which is considered to be similar to the average western Brazilian shield composition. Thus the overall compositions of the sands has been modeled as mechanical mixtures of two components, an Andean magmatic arc and the Brazilian shield-derived metasediments. The model is strongly supported by a plot of ε Nd (O) versus ε Sr (O) of the sands. In this plot, the Type 1 and 2 sands define two coherent hyperbolic trends contiguous with two different portions of the Andean magmatic trend. (orig./WB)

  5. Evolution of the Paleogene succession of the western Himalayan foreland basin

    Directory of Open Access Journals (Sweden)

    B.P. Singh


    Full Text Available The Paleogene succession of the Himalayan foreland basin is immensely important as it preserves evidence of India-Asia collision and related records of the Himalayan orogenesis. In this paper, the depositional regime of the Paleogene succession of the Himalayan foreland basin and variations in composition of the hinterland at different stages of the basin developments are presented. The Paleogene succession of the western Himalayan foreland basin developed in two stages, i.e. syn-collisional stage and post-collisional stage. At the onset, chert breccia containing fragments derived from the hanging walls of faults and reworked bauxite developed as a result of erosion of the forebulge. The overlying early Eocene succession possibly deposited in a coastal system, where carbonates represent barriers and shales represent lagoons. Up-section, the middle Eocene marl beds likely deposited on a tidal flat. The late Eocene/Oligocene basal Murree beds, containing tidal bundles, indicate that a mixed or semi-diurnal tidal system deposited the sediments and the sedimentation took place in a tide-dominated estuary. In the higher-up, the succession likely deposited in a river-dominated estuary or in meandering rivers. In the beginning of the basin evolution, the sediments were derived from the Precambrian basement or from the metasediments/volcanic rocks possessing terrains of the south. The early and middle Eocene (54.7–41.3 Ma succession of the embryonic foreland possibly developed from the sediments derived from the Trans-Himalayan schists and phyllites and Indus ophiolite of the north during syn-collisional stage. The detrital minerals especially the lithic fragments and the heavy minerals suggest the provenance for the late Eocene/Oligocene sequences to be from the recycled orogenic belt of the Higher Himalaya, Tethyan Himalaya and the Indus-suture zone from the north during post-collisional stage. This is also supported by the paleocurrent

  6. Spatial evolution of Zagros collision zone in Kurdistan - NW Iran, constraints for Arabia-Eurasia oblique convergence (United States)

    Sadeghi, S.; Yassaghi, A.


    Stratigraphy, detailed structural mapping and crustal scale cross section of the NW Zagros collision zone evolved during convergence of the Arabian and Eurasian plates were conducted to constrain the spatial evolution of the belt oblique convergence since Late Cretaceous. Zagros orogeny in NW Iran consists of the Sanandaj-Sirjan, Gaveh Rud and ophiolite zones as internal, and Bisotoun, Radiolarite and High Zagros zones as external parts. The Main Zagros Thrust is known as major structures of the Zagros suture zone. Two stages of deformation are recognized in the external parts of Zagros. In the early stage, presence of dextrally deformed domains beside the reversely deformed domains in the Radiolarite zone as well as dextral-reverse faults in both Bisotoun and Radiolarite zones demonstrates partitioning of the dextral transpression. In the late stage, southeastward propagation of the Zagros orogeny towards its foreland resulted in synchronous development of orogen-parallel strike-slip and pure thrust faults. It is proposed that the first stage related to the late Cretaceous oblique obduction, and the second stage is resulted from Cenozoic collision. Cenozoic orogen-parallel strike-slip component of Zagros oblique faulting is not confined to the Zagros suture zone (Main Recent) but also occurred in the more external part (Marekhil-Ravansar fault system). Thus, it is proposed that oblique convergence of Arabia-Eurasia plates occurred in Zagros collision zone since the Late Cretaceous.

  7. NW CSC annual report fiscal year 2013 (United States)

    Bisbal, Gustavo A.


    The Northwest Climate Science Center (NW CSC) was established in 2010 as one of eight regional Climate Science Centers created by the Department of the Interior (DOI). The NW CSC encompasses Washing-ton, Oregon, Idaho, and western Montana and has overlapping boundaries with three Landscape Conservation Cooperatives (LCCs): the Great Northern, the Great Basin, and the North Pacific. With guidance from its Executive Stakeholder Advisory Committee (ESAC), the NW CSC and its partner LCCs are addressing the highest priority regional climate science needs of Northwest natural and cultural resource managers. Climate Science Centers tap into the scientific expertise of both the U.S. Geological Survey (USGS) and academic institutions. The NW CSC is supported by an academic consortium with the capacity to generate climate science and tools in a coordinated fashion, serving stakeholders across the Northwest region. This consortium is primarily represented by Oregon State University (OSU), the University of Id-ho (UI), and the University of Washington (UW). The academic consortium and USGS provide capabilities in climate science, ecology, impacts and vulnerability assessment, modeling, adaptation planning, and advanced information technology, all necessary to address and respond to climate change in the Northwest. University members also recruit and train graduate students and early-career scientists. This Annual Report summarizes progress for the goals set out in the NW CSC Strategic Plan for 2012-2015 ( and the NW CSC Work-plan for Fiscal Year (FY) 2013 (October 1, 2012 through September 30, 2013). The report follows the structure of the Strategic Plan, which describes the five core services (Executive, Science, Data, Communications, and Education and Training) provided by the NW CSC in support of the stated vision: Our Vision: To become nationally recognized as a best-practice model for the provision

  8. Vocal Fold Collision Modeling

    DEFF Research Database (Denmark)

    Granados, Alba; Brunskog, Jonas; Misztal, M. K.


    When vocal folds vibrate at normal speaking frequencies, collisions occurs. The numerics and formulations behind a position-based continuum model of contact is an active field of research in the contact mechanics community. In this paper, a frictionless three-dimensional finite element model...

  9. Folding worlds between pages

    CERN Multimedia

    Meier, Matthias


    "We all remember pop-up books form our childhood. As fascinated as we were back then, we probably never imagined how much engineering know-how went into these books. Pop-up engineer Anton Radevsky has even managed to fold a 27-kilometre particle accelerator into a book" (4 pages)

  10. Folds and Etudes (United States)

    Bean, Robert


    In this article, the author talks about "Folds" and "Etudes" which are images derived from anonymous typing exercises that he found in a used copy of "Touch Typing Made Simple". "Etudes" refers to the musical tradition of studies for a solo instrument, which is a typewriter. Typing exercises are repetitive attempts to type words and phrases…

  11. The influence of late Miocene exhumation on the petroleum systems of the greater Caucasus foreland basins

    International Nuclear Information System (INIS)

    Andy, A.; Colin, D.; Sally, H.; Simon, O.


    Full text: Northwards impingement of Arabia during the Cenozoic led to the inversion of the Mesozoic Greater Caucasus Basin and the associated development of areas of enhanced subsidence. However, there is great debate regarding the timing of initiation of thrusting and uplift in the Caucasus region.Traditionally, ages ranging from Middle Eocene through to Middle Miocene have been proposed.More recently. It has become clear that although deformation and flexural subsidence may have initiated during the Late Miocene to Pliocene.The potential causative mechanisms for this late uplift and exhumation did not begin until the Late Miocene to Pliocene.The potential causative mechanisms for this late uplift event have been identified.The late Miocene to Pliocene event influenced a broad region and had important implications for reservoir rock deposition and the generation,migration,trapping and preservation of hydrocarbons in the surrounding basins (e.g. Indolo-Kuban,Terek-Caspian, South Caspian, Kura-Kartli, Rion, Black Sea).One area of particular interest is the development of the Stavropol Arch through time,since foreland basins are presently restricted to the Indolo-Kuban and Terek-Caspian Sub-basins.The Stavropol Arch lies immediately north of the central, most elevated parts of the Caucasus Mountains and separates the main areas of enhanced foreland subsidence.Although in most palaeogeographic reconstructions of the area, the Stavropol Arch is shown as an uplifted massif during much of the Mesozoic and Lower Cenozoic, it seems likely from recent studies that it is a feature of Late Miocene to Pliocene exhumation.One major potential implication is that an Oligocene to Miocene (foreland) succession developed in a major basin across the whole region north of the Greater Caucasus.Much of this was subsequently eroded from the Stavropol Arch during uplift and exhumation, separating the Indolo-Kuban and Terek-Caspian foreland basins.From qualitative section balancing we

  12. Cenozoic foreland basins of Central Andes: a preliminary provenance U-Pb zircon analysis of sedimentary sequences of Calchaqui Valley

    International Nuclear Information System (INIS)

    Oliveira, Alisson Lopes; Hauser, Natalia; Pimentel, Marcio Martins; Matteini, Massimo; Coira, Beatriz; Alonso, Ricardo; Barrientos, Andrea


    The Eocene of northwestern Argentina records complex basin and structural evolution, including continental sedimentation of the post-rift Salta Basin and the beginning of the Andean uplift and foreland system evolution. This illuminates a significant period of evolutionary history of this and surrounding basins in northwestern Argentina. U-Pb zircon analyses by LA-ICP-MS for three formations representing post-rift to foreland stages allowed interpretation about provenance terrains. The Lumbrera Formation, representing the post-rift stage, shows bimodal sources with a main zircon population around 462 Ma, and a second population around 1023 Ma. The Los Colorados and Angastaco Formations representing the sedimentation in a foreland basin, show a unimodal source around 490 Ma, and 517 Ma respectively. Zircons younger than 50 Ma were not identified during this study. (author)

  13. Cenozoic foreland basins of Central Andes: a preliminary provenance U-Pb zircon analysis of sedimentary sequences of Calchaqui Valley

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Alisson Lopes; Hauser, Natalia; Pimentel, Marcio Martins; Matteini, Massimo, E-mail: [Universidade de Brasilia (UnB), DF (Brazil). Laboratorio de Geocronologia; Galli, Claudia Ines [Faculdad de Ingenieria, Universidad Nacional de Jujuy (Argentina); Coira, Beatriz [CIT Jujuy, CONICET. Instituto de Geologia y Mineria (Argentina); Alonso, Ricardo; Barrientos, Andrea [Instituto CEGA, CONICET. Universidad Nacional de Salta (Argentina)


    The Eocene of northwestern Argentina records complex basin and structural evolution, including continental sedimentation of the post-rift Salta Basin and the beginning of the Andean uplift and foreland system evolution. This illuminates a significant period of evolutionary history of this and surrounding basins in northwestern Argentina. U-Pb zircon analyses by LA-ICP-MS for three formations representing post-rift to foreland stages allowed interpretation about provenance terrains. The Lumbrera Formation, representing the post-rift stage, shows bimodal sources with a main zircon population around 462 Ma, and a second population around 1023 Ma. The Los Colorados and Angastaco Formations representing the sedimentation in a foreland basin, show a unimodal source around 490 Ma, and 517 Ma respectively. Zircons younger than 50 Ma were not identified during this study. (author)

  14. Fracture patterns in the Zagros fold-and-thrust belt, Kurdistan Region of Iraq (United States)

    Reif, Daniel; Decker, Kurt; Grasemann, Bernhard; Peresson, Herwig


    Fracture data have been collected in the Kurdistan Region of Iraq, which is a poorly accessible and unexplored area of the Zagros. Pre to early folding NE-SW striking extensional fractures and NW-SE striking contractive elements represent the older set affecting the exposed multilayer of the area. These latter structures are early syn-folding and followed by folding-related mesostructural assemblages, which include elements striking parallel to the axial trend of major folds (longitudinal fractures). Bedding perpendicular joints and veins, and extensional faults belonging to this second fracture set are located in the outer arc of exposed anticlines, whilst longitudinal reverse faults locate in the inner arcs. Consistently, these elements are associated with syn-folding tangential longitudinal strain. The younger two sets are related to E-W extension and NNE-SSW to N-S shortening, frequently displaying reactivation of the older sets. The last shortening event, which is described along the entire Zagros Belt, probably relates with the onset of N-S compression induced by the northward movement of the Arabian plate relative to the Eurasian Plate. In comparison between the inferred palaeostrain directions and the kinematics of recent GPS measurements, we conclude that the N-S compression and the partitioning into NW-SE trending folds and NW to N trending strike-slip faults likely remained unchanged throughout the Neogene tectonic history of the investigated area.

  15. Spatial evolution of Zagros collision zone in Kurdistan, NW Iran: constraints on Arabia-Eurasia oblique convergence (United States)

    Sadeghi, Shahriar; Yassaghi, Ali


    Stratigraphy, detailed structural mapping and a crustal-scale cross section across the NW Zagros collision zone provide constraints on the spatial evolution of oblique convergence of the Arabian and Eurasian plates since the Late Cretaceous. The Zagros collision zone in NW Iran consists of the internal Sanandaj-Sirjan, Gaveh Rud and Ophiolite zones and the external Bisotoun, Radiolarite and High Zagros zones. The Main Zagros Thrust is the major structure of the Zagros suture zone. Two stages of oblique deformation are recognized in the external part of the NW Zagros in Iran. In the early stage, coexisting dextral strike-slip and reverse dominated domains in the Radiolarite zone developed in response to deformation partitioning due to oblique convergence. Dextral-reverse faults in the Bisotoun zone are also compatible with oblique convergence. In the late stage, deformation partitioning occurred during southeastward propagation of the Zagros orogeny towards its foreland resulting in synchronous development of orogen-parallel strike-slip and thrust faults. It is proposed that the first stage was related to Late Cretaceous oblique obduction, while the second stage resulted from Cenozoic collision. The Cenozoic orogen-parallel strike-slip component of Zagros oblique convergence is not confined to the Zagros suture zone (Main Recent Fault) but also occurred in the external part (Marekhil-Ravansar fault system). Thus, it is proposed that oblique convergence of Arabian and Eurasian plates in Zagros collision zone initiated with oblique obduction in the Late Cretaceous followed by oblique collision in the late Tertiary, consistent with global plate reconstructions.

  16. Plio-Pleistocene paleo-erosion rates as a recorder of orographic barrier uplift in the NW-Argentine Andes (Humahuaca Basin) (United States)

    Pingel, Heiko; Schildgen, Taylor; Wittmann, Hella


    As an integral part of the Eastern Cordillera, the intermontane Humahuaca Basin in the NW Argentine Andes is located in transition between the arid and internally drained Puna Plateau to the west and the humid broken foreland to the east. In combination with moisture-bearing air masses sourced in the Atlantic Ocean and the Amazon Basin, the present-day topographic gradient of the eastern Andean margin comprises an efficient orographic barrier that results in a strong precipitation gradient, with rainfall of more than 2,000 mm/a along the eastern flanks and history of the basin highlights important changes of the depositional system, apparently associated with the transformation from a humid foreland to a fluvially restricted and semi-arid intermontane basin. Similarly, our terrestrial cosmogenic nuclide-derived data indicate an order-of-magnitude decrease in erosion rates at ca. 3 Ma, which suggests a causal link between the onset of uplift-induced semi-arid conditions and decreasing sediment flux into the basin. Ultimately, this dataset may enable a systematic investigation of the long-term causes and consequences of orogenic growth and hydrological changes on spatio-temporal erosion patterns in active mountain areas.

  17. Characteristics of Chinese petroleum geology. Geological features and exploration cases of stratigraphic, foreland and deep formation traps

    Energy Technology Data Exchange (ETDEWEB)

    Jia, Chengzao [PetroChina Company Limited, Beijing (China)


    The first book of this subject in the recent 10 years. ''Characteristics of Chinese Petroleum Geology: Geological Features and Exploration Cases of Stratigraphic, Foreland and Deep Formation Traps'' systematically presents the progress made in petroleum geology in China and highlights the latest advances and achievements in oil/gas exploration and research, especially in stratigraphic, foreland and deep formation traps. The book is intended for researchers, practitioners and students working in petroleum geology, and is also an authoritative reference work for foreign petroleum exploration experts who want to learn more about this field in China.

  18. Physics of protein folding (United States)

    Finkelstein, A. V.; Galzitskaya, O. V.


    Protein physics is grounded on three fundamental experimental facts: protein, this long heteropolymer, has a well defined compact three-dimensional structure; this structure can spontaneously arise from the unfolded protein chain in appropriate environment; and this structure is separated from the unfolded state of the chain by the “all-or-none” phase transition, which ensures robustness of protein structure and therefore of its action. The aim of this review is to consider modern understanding of physical principles of self-organization of protein structures and to overview such important features of this process, as finding out the unique protein structure among zillions alternatives, nucleation of the folding process and metastable folding intermediates. Towards this end we will consider the main experimental facts and simple, mostly phenomenological theoretical models. We will concentrate on relatively small (single-domain) water-soluble globular proteins (whose structure and especially folding are much better studied and understood than those of large or membrane and fibrous proteins) and consider kinetic and structural aspects of transition of initially unfolded protein chains into their final solid (“native”) 3D structures.

  19. Molecular Identification of Adult and Juvenile Linyphiid and Theridiid Spiders in Alpine Glacier Foreland Communities (United States)

    Raso, Lorna; Sint, Daniela; Rief, Alexander; Kaufmann, Rüdiger; Traugott, Michael


    In glacier forelands spiders constitute a large proportion of the invertebrate community. Therefore, it is important to be able to determine the species that can be found in these areas. Linyphiid and theridiid spider identification is currently not possible in juvenile specimens using traditional morphological based methods, however, a large proportion of the population in these areas are usually juveniles. Molecular methods permit identification of species at different life stages, making juvenile identification possible. In this study we tested a molecular tool to identify the 10 most common species of Linyphiidae and Theridiidae found in three glacier foreland communities of the Austrian Alps. Two multiplex PCR systems were developed and over 90% of the 753 field-collected spiders were identified successfully. The species targeted were found to be common in all three valleys during the summer of 2010. A comparison between the molecular and morphological data showed that although there was a slight difference in the results, the overall outcome was the same independently of the identification method used. We believe the quick and reliable identification of the spiders via the multiplex PCR assays developed here will aid the study of these families in Alpine habitats. PMID:25050841

  20. Bacterial diversity in the foreland of the Tianshan No. 1 glacier, China

    International Nuclear Information System (INIS)

    Wu Xiukun; Zhang Wei; Liu Guangxiu; Zhang Gaosen; Yang Xuan; Hu Ping; Chen Tuo; Li Zhongqin


    There is compelling evidence that glaciers are retreating in many mountainous areas of the world due to global warming. With this glacier retreat, new habitats are being exposed that are colonized by microorganisms whose diversity and function are less well studied. Here, we characterized bacterial diversity along the chronosequences of the glacier No. 1 foreland that follows glacier retreat. An average of 10 000 sequences was obtained from each sample by 454 pyrosequencing. Using non-parametric and rarefaction estimated analysis, we found bacterial phylotype richness was high. The bacterial species turnover rate was especially high between sites exposed for 6 and 10 yr. Pyrosequencing showed tremendous bacterial diversity, among which the Acidobacteria, Actinobacteria, Bacteroidetes and Proteobacteria were found to be present at larger numbers at the study area. Meanwhile, the proportion of Bacteroidetes and Proteobacteria decreased and the proportion of Acidobacteria increased along the chronosequences. Some known functional bacterial genera were also detected and the sulfur- and sulfate-reducing bacteria were present in a lower proportion of sequences. These findings suggest that high-throughput pyrosequencing can comprehensively detect bacteria in the foreland, including rare groups, and give a deeper understanding of the bacterial community structure and variation along the chronosequences. (letter)

  1. Bacterial diversity in the foreland of the Tianshan No. 1 glacier, China

    Energy Technology Data Exchange (ETDEWEB)

    Xiukun, Wu; Wei, Zhang; Guangxiu, Liu; Gaosen, Zhang [Key Laboratory of Desert and Desertification, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou (China); Xuan, Yang; Ping, Hu [School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou (China); Tuo, Chen; Li Zhongqin, E-mail: [State Key Laboratory of Cryospheric Sciences, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou (China)


    There is compelling evidence that glaciers are retreating in many mountainous areas of the world due to global warming. With this glacier retreat, new habitats are being exposed that are colonized by microorganisms whose diversity and function are less well studied. Here, we characterized bacterial diversity along the chronosequences of the glacier No. 1 foreland that follows glacier retreat. An average of 10 000 sequences was obtained from each sample by 454 pyrosequencing. Using non-parametric and rarefaction estimated analysis, we found bacterial phylotype richness was high. The bacterial species turnover rate was especially high between sites exposed for 6 and 10 yr. Pyrosequencing showed tremendous bacterial diversity, among which the Acidobacteria, Actinobacteria, Bacteroidetes and Proteobacteria were found to be present at larger numbers at the study area. Meanwhile, the proportion of Bacteroidetes and Proteobacteria decreased and the proportion of Acidobacteria increased along the chronosequences. Some known functional bacterial genera were also detected and the sulfur- and sulfate-reducing bacteria were present in a lower proportion of sequences. These findings suggest that high-throughput pyrosequencing can comprehensively detect bacteria in the foreland, including rare groups, and give a deeper understanding of the bacterial community structure and variation along the chronosequences. (letter)

  2. Quantification of fold growth of frontal antiforms in the Zagros fold and thrust belt (Kurdistan, NE Iraq) (United States)

    Bretis, Bernhard; Bartl, Nikolaus; Graseman, Bernhard; Lockhart, Duncan


    The Zagros fold and thrust belt is a seismically active orogen, where actual kinematic models based on GPS networks suggest a north-south shortening between Arabian and Eurasian in the order of 1.5-2.5 cm/yr. Most of this deformation is partitioned in south-southwest oriented folding and thrusting with northwest-southeast to north-south trending dextral strike slip faults. The Zagros fold and thrust belt is of great economic interest because it has been estimated that this area contains about 15% of the global recoverable hydrocarbons. Whereas the SE parts of the Zagros have been investigated by detailed geological studies, the NW extent being part of the Republic of Iraq have experienced considerably less attention. In this study we combine field work and remote sensing techniques in order to investigate the interaction of erosion and fold growth in the area NE of Erbil (Kurdistan, Iraq). In particular we focus on the interaction of the transient development of drainage patterns along growing antiforms, which directly reflects the kinematics of progressive fold growth. Detailed geomorphological studies of the Bana Bawi-, Permam- and Safeen fold trains show that these anticlines have not developed from subcylindrical embryonic folds but they have merged from different fold segments that joined laterally during fold amplification. This fold segments with length between 5 and 25 km have been detected by mapping ancient and modern river courses that initially cut the nose of growing folds and eventually got defeated leaving behind a wind gap. Fold segments, propagating in different directions force rivers to join resulting in steep gorges, which dissect the merging fold noses. Along rapidly lateral growing folds (e.g. at the SE end of the Bana Bawi Anticline) we observed "curved wind gaps", a new type of abandoned river course, where form of the wind gap mimics a formed nose of a growing antiform. The inherited curved segments of uplifted curved river courses strongly

  3. Sedimentary Evolution of Marginal Ganga Foreland Basin during the Late Pleistocene (United States)

    Ghosh, R.; Srivastava, P.; Shukla, U. K.


    Ganga foreland basin, an asymmetrical basin, was formed as result of plate-plate collision during middle Miocene. A major thrust event occurred during 500 ka when upper Siwalik sediments were uplifted and the modern Ganga foreland basin shifted towards craton, making a more wide and deep basin. The more distal part of this basin, south of axial river Yamuna, records fluvial sedimentary packages that helps to understand dynamics of peripheral bulge during the late Quaternary. Sedimentary architecture in conjunction with chemical index of alteration (CIA), paleocurrent direction and optically stimulated dating (OSL) from 19 stratigraphic sections helped reconstructing the variations in depositional environments vis-à-vis climate change and peripheral bulge tectonics. Three major units (i) paleosol; (ii) cratonic gravel; (iii) interfluve succession were identified. The lower unit-I showing CIA values close to 70-80 and micro-morphological features of moderately well-developed pedogenic unit that shows development of calcrete, rhizoliths, and mineralized organic matter in abundance. This is a regional paleosols unit and OSL age bracketed 200 ka. This is unconformably overlain by unit-II, a channelized gravel composed of sub-angular to sub-rounded clasts of granite, quartz, quartzite, limestone and calcrete. The gravel have low CIA value up to 55, rich in vertebrate fossil assemblages and mean paleocurrent vector direction is NE, which suggesting deposition by a fan of a river draining craton into foreland. This unit is dated between 100 ka and 54 ka. The top unit-III, interfluve succession of 10-15 m thick is composed of dark and light bands of sheet like deposit of silty clay to clayey silt comprises sand lenses of red to grey color and displaying top most OSL age is 12 ka. The basal mature paleosol signifies a humid climate developed under low subsidence rate at >100 ka. After a hiatus represented by pedogenic surface deposition of unit-II (gravel) suggests uplift

  4. A Multi-Proxy Analysis of two Loess-Paleosol Sequences in the Northern Harz Foreland (United States)

    Krauss, Lydia; Zens, Joerg; Zeeden, Christian; Schulte, Philipp; Eckmeier, Eileen; Lehmkuhl, Frank


    Within the second phase of the "Collaborative Research Centre 806 (CRC806) - Our Way to Europe - Culture-Environment Interaction and Human Mobility in the Late Quaternary" two loess-paleosol sections in the northern Harz foreland are being investigated. The region is part of the Northern European loess belt. The northern edge of the loess distribution is characterized by an interlocking of Weichselian silt and sand sized aeolian sediments. To the south the Northern European loess belt is limited by the central German uplands (Mittelgebirge). Here the continuous loess cover disperses into separated loess basins. In comparison to relatively long, continuous and intensively studied sections, e.g. along the Rhine river, investigations on loess-paleosol sequences in the northern Harz foreland have been sparse so far. In 2006 REINECKE created an overview of Pleistocene landscape developments by investigating terrace sequences and loess sections in this area. Due to improvements of research methods over the last ten years, the two loess-paleosol sequences Hecklingen and Zilly are being reinvestigated. Aiming towards a better understanding of the paleoenvironmental conditions during the Weichselian in an area close to the Scandinavian ice sheet, results from grain size, geochemical (XRF, CNS) and color measurements are combined. The results show an increased input of aeolian material during the last glacial maximum and the last cover loess period, supporting the theory of dryer and colder conditions during this time frame. Further, we can see a stronger short distant input within the recent soil and during the last glacial maximum in both profiles. In Hecklingen this is also observed within the MIS 3 soil material. Since soil material dating to the MIS 3 is present, we can assume that surface processes where less intrusive during the MIS 3 and 2 as in e.g. the Lower Rhine Embayment. REINECKE, V. (2006): Untersuchungen zur mittel- und jungpleistozänen Reliefentwicklung und

  5. A new age model for the early-middle Miocene in the North Alpine Foreland Basin (United States)

    Reichenbacher, Bettina; Krijgsman, Wout; Pippèrr, Martina; Sant, Karin; Kirscher, Uwe


    The establishment of high-resolution age models for sedimentary successions is crucial for numerous research questions in the geosciences and related disciplines. Such models provide an absolute chronology that permits precise dating of depositional episodes and related processes such as mountain uplift or climate change. Recently, our work in the Miocene sediments of the North Alpine Foreland Basin (NAFB) has revealed a significantly younger age (16.6 Myr) for sediments that were thought to have been deposited 18 Myr ago. This implies that a fundamentally revised new age model is needed for the entire suite of lower-middle Miocene sedimentary rocks in the NAFB (20 to 15-Myr). Our new data also indicate that previously published reconstructions of early-middle Miocene palaeogeography, sedimentation dynamics, mountain uplift and climate change in the NAFB all require a critical review and revision. Further, the time-span addressed is of special interest, since it encompasses the onset of a global warming phase. However, it appears that a fundamentally revised new age model for the entire suite of lower-middle Miocene sedimentary rocks in the NAFB can only be achieved based on a 500 m deep drilling in the NAFB for which we currently seek collaboration partners to develop a grant application to the International Continental Deep Drilling Program (ICDP). Reference: Reichenbacher, B., W. Krijgsman, Y. Lataster, M. Pippèrr, C. G. C. Van Baak, L. Chang, D. Kälin, J. Jost, G. Doppler, D. Jung, J. Prieto, H. Abdul Aziz, M. Böhme, J. Garnish, U. Kirscher, and V. Bachtadse. 2013. A new magnetostratigraphic framework for the Lower Miocene (Burdigalian/Ottnangian, Karpatian) in the North Alpine Foreland Basin. Swiss Journal of Geosciences 106:309-334.

  6. AD1995: NW Europe's hydrocarbon industry

    International Nuclear Information System (INIS)

    Glennie, K.; Hurst, A.


    This volume concerns itself with wide-ranging aspects of the upstream hydro-carbon industry over the whole of NW Europe. As such, the book contrasts with many thematic volumes by presenting a broad range of topics side-by-side. One section of the book looks back at the history of geological exploration and production, and provides an overview of hydrocarbon exploration across NW Europe. Another section covers the state of the art in hydrocarbon exploration and production. This includes an update on computer-based basin modelling overpressure systems, innovations in reservoir engineering and reserve estimation, 3D seismic and the geochemical aspects of secondary migration. The final section of the book takes a look into the future. This covers the remaining hydrocarbon resources of the North Sea, managing risk in oil field development, oil field economics, and pollution and the environment. It is the editors' hope that several key areas of NW Europe's upstream oil industry have been usefully summarized in the volume. (Author)

  7. The Complexity of Folding Self-Folding Origami

    Directory of Open Access Journals (Sweden)

    Menachem Stern


    Full Text Available Why is it difficult to refold a previously folded sheet of paper? We show that even crease patterns with only one designed folding motion inevitably contain an exponential number of “distractor” folding branches accessible from a bifurcation at the flat state. Consequently, refolding a sheet requires finding the ground state in a glassy energy landscape with an exponential number of other attractors of higher energy, much like in models of protein folding (Levinthal’s paradox and other NP-hard satisfiability (SAT problems. As in these problems, we find that refolding a sheet requires actuation at multiple carefully chosen creases. We show that seeding successful folding in this way can be understood in terms of subpatterns that fold when cut out (“folding islands”. Besides providing guidelines for the placement of active hinges in origami applications, our results point to fundamental limits on the programmability of energy landscapes in sheets.

  8. The Complexity of Folding Self-Folding Origami (United States)

    Stern, Menachem; Pinson, Matthew B.; Murugan, Arvind


    Why is it difficult to refold a previously folded sheet of paper? We show that even crease patterns with only one designed folding motion inevitably contain an exponential number of "distractor" folding branches accessible from a bifurcation at the flat state. Consequently, refolding a sheet requires finding the ground state in a glassy energy landscape with an exponential number of other attractors of higher energy, much like in models of protein folding (Levinthal's paradox) and other NP-hard satisfiability (SAT) problems. As in these problems, we find that refolding a sheet requires actuation at multiple carefully chosen creases. We show that seeding successful folding in this way can be understood in terms of subpatterns that fold when cut out ("folding islands"). Besides providing guidelines for the placement of active hinges in origami applications, our results point to fundamental limits on the programmability of energy landscapes in sheets.

  9. Time-dependent thermal state of the lithosphere in the foreland of the Eastern Carpathians bend. Insights from new geothermal measurements and modelling results

    DEFF Research Database (Denmark)

    Demetrescu, Crisan; Wilhelm, H.; Tumanian, M.


    in establishing the temperature field in the depth range of geothermal measurements. The lateral variation of the palaeoclimatically corrected surface heat flux from the centre of the Focsani Depression (40 mW m-2) to its margin and the foreland platform (70 mW m-2) is mainly the result of the lateral variation...... words: Carpathians foreland, geothermics, heat flow, lithosphere rheology, sedimentation, thermal modelling.  ...

  10. RNA folding: structure prediction, folding kinetics and ion electrostatics. (United States)

    Tan, Zhijie; Zhang, Wenbing; Shi, Yazhou; Wang, Fenghua


    Beyond the "traditional" functions such as gene storage, transport and protein synthesis, recent discoveries reveal that RNAs have important "new" biological functions including the RNA silence and gene regulation of riboswitch. Such functions of noncoding RNAs are strongly coupled to the RNA structures and proper structure change, which naturally leads to the RNA folding problem including structure prediction and folding kinetics. Due to the polyanionic nature of RNAs, RNA folding structure, stability and kinetics are strongly coupled to the ion condition of solution. The main focus of this chapter is to review the recent progress in the three major aspects in RNA folding problem: structure prediction, folding kinetics and ion electrostatics. This chapter will introduce both the recent experimental and theoretical progress, while emphasize the theoretical modelling on the three aspects in RNA folding.

  11. Early Tertiary Exhumation, Erosion, and Sedimentation in the Central Andes, NW Argentina (United States)

    Carrapa, B.; Decelles, P. G.; Gerhels, G.; Mortimer, E.; Strecker, M. R.


    Timing of deformation and resulting sedimentation patterns in the Altiplano-Puna Plateau-Eastern Cordillera of the southern Central Andes are the subject of ongoing controversial debate. In the Bolivian Altiplano, sedimentation into a foreland basin system commenced during the Paleocene. Farther south in the Puna and Eastern Cordillera of NW Argentina, a lack of data has precluded a similar interpretation. Early Tertiary non-marine sedimentary rocks are preserved within the present day Puna Plateau and Eastern Cordillera of NW Argentina. The Salar de Pastos Grandes basin in the Puna Plateau contains more than 2 km of Eocene alluvial and fluvial strata in the Geste Formation, deposited in close proximity to orogenic source terrains. Sandstone and conglomerate petrographic data document Ordovician quartzites and minor phyllites and schists as the main source rocks. Detrital zircon U-Pb ages from both the Geste Formation and from underlying Ordovician quartzite cluster in the 900-1200 Ma (Grenville) and late Precambrian-Cambrian (Panafrican) ranges. Sparse late Eocene (~37-34 Ma) grains are also present; their large size, euhedral shape, and decreasing mean ages upsection suggest that these grains are volcanogenic (i.e. ash fall contamination), derived from an inferred magmatic arc to the west. The Eocene ages corroborate mammalian paleontological dates, defining the approximate begin of deposition of the Geste Formation. Alternatively, these young zircons could be of plutonic origin; however, no Eocene plutons are present in the surrounding source rocks and this interpretation is not likely. From W to E, fluvial rocks of the Quebrada de los Colorados Formation show similar sedimentological features as those observed for the Geste Formation, suggesting a genetic link between the two. Detrital zircon U-Pb data show mainly Panafrican ages, with sparse ages in the 860-935 Ma range and a few mid-Proterozoic ages. More importantly, a significant number of late Eocene

  12. Cenozoic structural evolution, thermal history, and erosion of the Ukrainian Carpathians fold-thrust belt (United States)

    Nakapelyukh, Mykhaylo; Bubniak, Ihor; Bubniak, Andriy; Jonckheere, Raymond; Ratschbacher, Lothar


    The Carpathians are part of the Alpine-Carpathian-Dinaridic orogen surrounding the Pannonian basin. Their Ukrainian part constitutes an ancient subduction-accretion complex that evolved into a foreland fold-thrust belt with a shortening history that was perpendicular to the orogenic strike. Herein, we constrain the evolution of the Ukrainian part of the Carpathian fold-thrust belt by apatite fission-track dating of sedimentary and volcanic samples and cross-section balancing and restoration. The apatite fission-track ages are uniform in the inner―southwestern part of the fold-thrust belt, implying post-shortening erosion since 12-10 Ma. The ages in the leading and trailing edges record provenance, i.e., sources in the Trans-European suture zone and the Inner Carpathians, respectively, and show that these parts of the fold-thrust were not heated to more than 100 °C. Syn-orogenic strata show sediment recycling: in the interior of the fold-thrust belt―the most thickened and most deeply eroded nappes―the apatite ages were reset, eroded, and redeposited in the syn-orogenic strata closer to the fore- and hinterland; the lag times are only a few million years. Two balanced cross sections, one constructed for this study and based on field and subsurface data, reveal an architecture characterized by nappe stacks separated by high-displacement thrusts; they record 340-390 km shortening. A kinematic forward model highlights the fold-thrust belt evolution from the pre-contractional configuration over the intermediate geometries during folding and thrusting and the post-shortening, erosional-unloading configuration at 12-10 Ma to the present-day geometry. Average shortening rates between 32-20 Ma and 20-12 Ma amounted to 13 and 21 km/Ma, respectively, implying a two-phased deformation of the Ukrainian fold-thrust belt.

  13. The kinematic evolution of the Serra Central Salient, Eastern Brazil: A Neoproterozoic progressive arc in northern Espinhaço fold-thrust belt (United States)

    Bersan, Samuel Moreira; Danderfer, André; Lagoeiro, Leonardo; Costa, Alice Fernanda de Oliveira


    Convex-to-the-foreland map-view curves are common features in fold-thrust belts around cratonic areas. These features are easily identifiable in belts composed of supracrustal rocks but have been rarely described in rocks from relatively deeper crustal levels where plastic deformation mechanisms stand out. Several local salients have been described in Neoproterozoic marginal fold-thrust belts around the São Francisco craton. In the northern part of the Espinhaço fold-thrust belt, which borders the eastern portion of the São Francisco craton, both Archean-Paleoproterozoic basement rocks and Proterozoic cover rocks are involved in the so-called Serra Central salient. A combination of conventional structural analysis and microstructural and paleostress studies were conducted to characterize the kinematic and the overall architecture and processes involved in the generation of this salient. The results allowed us to determine that the deformation along the Serra Central salient occur under low-grade metamorphic conditions and was related to a gently oblique convergence with westward mass transport that developed in a confined flow, controlled by two transverse bounding shear zones. We propose that the Serra Central salient nucleates as a basin-controlled primary arc that evolves to a progressive arc with secondary vertical axis rotation. This secondary rotation, well-illustrated by the presence of two almost orthogonal families of folds, was dominantly controlled by buttress effect exert by a basement high located in the foreland of the Serra Central salient.

  14. Quantifying the role of mantle forcing, crustal shortening and exogenic forcing on exhumation of the North Alpine Foreland Basin (United States)

    von Hagke, C.; Luijendijk, E.; Hindle, D.


    In contrast to the internal zones of orogens, where the stacking of thrust sheets can overwhelm more subtle signals, foreland basins can record long-wavelength subsidence or uplift signals caused by mantle processes. We use a new and extensive compilation of geological and thermochronology data from the North Alpine Foreland Basin to understand the dynamics of foreland basins and their interaction with surface and geodynamic processes. We quantify cooling and exhumation rates in the basin by combining published and new vitrinite reflectance, apatite fission track and U-Th/He data with a new inverse burial and thermal history model, pybasin. No correlation is obvious between inferred cooling and exhumation rates and elevation, relief or tectonics. Uncertainty analysis shows that thermochronometers can be explained by cooling starting as early as the Miocene or as late as the Pleistocene. We compare derived temperature histories to exhumation estimates based on the retro-deformation of Molasse basin and the Jura mountains, and to exhumation caused by drainage reorganization and incision. Drainage reorganization can explain at most 25% of the observed cooling rates in the basin. Tectonic transport of the basin's sediments over the inclined basement of the alpine foreland as the Jura mountains shortened can explain part of the cooling signal in the western part of the basin. However, overall a substantial amount of cooling and exhumation remains unexplained by known tectonic and surface processes. Our results document basin wide exhumation that may be related to slab roll-back or other lithospheric processes. We suggest that new (U-Th)/He data from key areas close to the Alpine front may provide better constraints on the timing of exhumation.

  15. The diversity and biogeography of the communities of Actinobacteria in the forelands of glaciers at a continental scale (United States)

    Zhang, Binglin; Wu, Xiukun; Zhang, Gaosen; Li, Shuyan; Zhang, Wei; Chen, Ximing; Sun, Likun; Zhang, Baogui; Liu, Guangxiu; Chen, Tuo


    Glacier forelands, where the initially exposed area is unvegetated with minimal human influence, are an ideal place for research on the distributions and biogeography of microbial communities. Actinobacteria produce many bioactive substances and have important roles in soil development and biogeochemical cycling. However, little is known about the distribution and biogeography of Actinobacteria in glacier forelands. Therefore, we investigated the patterns of diversity and the biogeography of actinobacterial communities of the inhabited forefields of 5 glaciers in China. Of the bacteria, the mean relative abundance of Actinobacteria was 13.1%, and 6 classes were identified in the phylum Actinobacteria. The dominant class was Actinobacteria (57%), which was followed in abundance by Acidimicrobiia (19%) and Thermoleophilia (19%). When combined, the relative abundance of the other three classes, the MB-A2-108, Nitriliruptoria and Rubrobacteria, was only 2.4%. A biogeographic pattern in the forelands of the 5 glaciers in China was not detected for actinobacterial communities. Compared with 7 other actinobacterial communities found in the forelands of glaciers globally, those in the Southern Hemisphere were significantly different from those in the Northern Hemisphere. Moreover, the communities were significantly different on the separate continents of the Northern Hemisphere. The dissimilarity of the actinobacterial communities increased with geographic distance (r = 0.428, p = 0.0003). Because of environmental factors, the effect of geography was clear when the distance exceeded a certain continent-level threshold. With the analysis of indicator species, we found that each genus had a geographic characteristic, which could explain why the communities with greater diversity were more strongly affected by biogeography.

  16. Paleocene-middle Miocene flexural-margin migration of the non marine llanos Foreland basin of Colombia

    International Nuclear Information System (INIS)

    Bayona, German; Jaramillo, Carlos; Rueda, Milton; Reyes Harker, Andres; Torres, Vladimir


    A foreland basin is a dynamic system whose depositional systems migrate in response to changes in tectonic uplift patterns, sedimentary filling processes and isostatic rebound of the lithosphere. The Paleocene-middle Miocene foreland system of the llanos foothills and llanos basin of Colombia includes regional unconformities, abrupt changes in lithology/stacking patterns and flooding surfaces bounding reservoir and seal units. Here we integrate a systematic biostratigraphic study, strata architecture and tectonic subsidence analyses, regional seismic profiles, and provenance data to define the diachronism of such surfaces and to document the direction of migration of foreland depozones. Line a flexural-deformed basin, sandstone composition, rates of accommodation and sediment supply vary across and along the basin. we show how a coeval depositional profile in the llanos foothills-llanos foreland basin consists of lithoranites inter b edded with mudstones (seal rock, supplied from the orogenic front to the west) that correlate craton ward with organic-rich mudstones and coal (source rock), and to amalgamated fluvial-estuarine quartzarenites (reservoir rock, supplied from the craton to the east) adjacent to a sub-aerial fore-bulge (unconformity). This system migrated northward and eastward during the Paleocene, westward during the early-middle Eocene, and eastward during the Oligocene. In the lower-middle Miocene succession of the llanos basin, identification of flooding events indicates a westward encroaching of a shallow-water lacustrine system that covered an eastward-directed fluvial-deltaic system. A similar process has been documented in other basins in Venezuela and Bolivia, indicating the regional extent of such flooding event may be related to the onset of Andean-scale mountain-building processes

  17. Vocal fold injection medialization laryngoplasty. (United States)

    Modi, Vikash K


    Unilateral vocal fold paralysis (UVFP) can cause glottic insufficiency that can result in hoarseness, chronic cough, dysphagia, and/or aspiration. In rare circumstances, UVFP can cause airway obstruction necessitating a tracheostomy. The treatment options for UVFP include observation, speech therapy, vocal fold injection medialization laryngoplasty, thyroplasty, and laryngeal reinnervation. In this chapter, the author will discuss the technique of vocal fold injection for medialization of a UVFP. Copyright © 2012 S. Karger AG, Basel.

  18. Link between Neogene and modern sedimentary environments in the Zagros foreland basin (United States)

    Pirouz, Mortaza; Simpson, Guy; Bahroudi, Abbas


    The Zagros mountain belt, with a length of 1800 km, is located in the south of Iran and was produced by collision between the Arabian plate and the Iran micro plate some time in the early Tertiary. After collision, the Zagros carbonate-dominated sedimentary basin has been replaced by a largely clastic system. The Neogene Zagros foreland basin comprises four main depositional environments which reflect the progressive southward migration of the deformation front with time. The oldest unit - the Gachsaran formation - is clastic in the northern part of the basin, but is dominated by evaporates in southern part, being deposited in a supratidal Sabkha-type environment. Overlying the Gachsaran is the Mishan formation, which is characterized by the Guri limestone member at the base, overlain by marine green marls. The thickness of the Guri member increases dramatically towards the southeast. The next youngest unit is the Aghajari Formation which consists of well sorted lenticular sandstone bodies in a red silty-mudstone. This formation is interpreted as representing the floodplain of dominantly meandering rivers. Finally, the Bakhtiari formation consists of mainly coarse-grained gravel sheets which are interpreted to represent braided river deposits. Each of these Neogene depositional environments has a modern day equivalent. For example, the braided rivers presently active in the Zagros mountains are modern analogues of the Bakhtiari. In the downstream direction, these braided rivers become meandering systems, which are equivalents of the Aghajari. Eventually, the meandering rivers meet the Persian gulf which is the site of the ‘modern day' Mishan shallow marine marls. Finally, the modern carbonate system on the southern margin of Persian Gulf represents the Guri member paleo-environment, behind which Sabkha-type deposits similar to the Gachsaran are presently being deposited. One important implication of this link between the Neogene foreland basin deposits and the

  19. Diagenetic Evolution and Reservoir Quality of Sandstones in the North Alpine Foreland Basin: A Microscale Approach. (United States)

    Gross, Doris; Grundtner, Marie-Louise; Misch, David; Riedl, Martin; Sachsenhofer, Reinhard F; Scheucher, Lorenz


    Siliciclastic reservoir rocks of the North Alpine Foreland Basin were studied focusing on investigations of pore fillings. Conventional oil and gas production requires certain thresholds of porosity and permeability. These parameters are controlled by the size and shape of grains and diagenetic processes like compaction, dissolution, and precipitation of mineral phases. In an attempt to estimate the impact of these factors, conventional microscopy, high resolution scanning electron microscopy, and wavelength dispersive element mapping were applied. Rock types were established accordingly, considering Poro/Perm data. Reservoir properties in shallow marine Cenomanian sandstones are mainly controlled by the degree of diagenetic calcite precipitation, Turonian rocks are characterized by reduced permeability, even for weakly cemented layers, due to higher matrix content as a result of lower depositional energy. Eocene subarkoses tend to be coarse-grained with minor matrix content as a result of their fluvio-deltaic and coastal deposition. Reservoir quality is therefore controlled by diagenetic clay and minor calcite cementation.Although Eocene rocks are often matrix free, occasionally a clay mineral matrix may be present and influence cementation of pores during early diagenesis. Oligo-/Miocene deep marine rocks exhibit excellent quality in cases when early cement is dissolved and not replaced by secondary calcite, mainly bound to the gas-water contact within hydrocarbon reservoirs.

  20. Biostratigraphy of a Paleocene–Eocene Foreland Basin boundary in southern Tibet

    Directory of Open Access Journals (Sweden)

    Xiaoqiao Wan


    Full Text Available This study of the Paleocene–Eocene boundary within a foreland basin of southern Tibet, which was dominated by a carbonate ramp depositional environment, documents more complex environmental conditions than can be derived from studies of the deep oceanic environment. Extinction rates for larger foraminiferal species in the Zongpu-1 Section apply to up to 46% of the larger foraminiferal taxa. The extinction rate in southern Tibet is similar to rates elsewhere in the world, but it shows that the Paleocene fauna disappeared stepwise through the Late Paleocene, with Eocene taxa appearing abruptly above the boundary. A foraminifera turnover was identified between Members 3 and 4 of the Zongpu Formation—from the Miscellanea–Daviesina assemblage to an Orbitolites–Alveolina assemblage. The Paleocene and Eocene boundary is between the SBZ 4 and SBZ 5, where it is marked by the extinction of Miscellanea miscella and the first appearance of Alveolina ellipsodalis and a large number of Orbitolites. Chemostratigraphically, the δ13C values from both the Zongpu-1 and Zongpu-2 Sections show three negative excursions in the transitional strata, one in Late Paleocene, one at the boundary, and one in the early Eocene. The second negative excursion of δ13C, which is located at the P–E boundary, coincides with larger foraminifera overturn. These faunal changes and the observed δ13C negative excursions provide new evidence on environmental changes across the Paleocene–Eocene boundary in Tibet.

  1. How old is your fold?

    NARCIS (Netherlands)

    Winstanley, Henry F.; Abeln, Sanne; Deane, Charlotte M.

    Motivation: At present there exists no age estimate for the different protein structures found in nature. It has become clear from occurrence studies that different folds arose at different points in evolutionary time. An estimation of the age of different folds would be a starting point for many

  2. Teaching computers to fold proteins

    DEFF Research Database (Denmark)

    Winther, Ole; Krogh, Anders Stærmose


    A new general algorithm for optimization of potential functions for protein folding is introduced. It is based upon gradient optimization of the thermodynamic stability of native folds of a training set of proteins with known structure. The iterative update rule contains two thermodynamic averages...

  3. Post-Cretaceous kinematics of the Atlas and Tell systems in central Algeria: Early foreland folding and subduction-related deformation

    NARCIS (Netherlands)

    Benaouali-Mebarek, N.; Frizon de Lamotte, D.; Roca, E.; Bracene, R.; Faure, J.L.; Sassi, W.; Roure, F.


    Available surface and industrial subsurface data provide the basis for a general balanced cross-section from the Sahara platform to the Mediterranean Sea in central Algeria. This section gives an overview of the whole Maghrebian orogen comprising from south to north the following structural domains:

  4. Periodic folding of viscous sheets (United States)

    Ribe, Neil M.


    The periodic folding of a sheet of viscous fluid falling upon a rigid surface is a common fluid mechanical instability that occurs in contexts ranging from food processing to geophysics. Asymptotic thin-layer equations for the combined stretching-bending deformation of a two-dimensional sheet are solved numerically to determine the folding frequency as a function of the sheet’s initial thickness, the pouring speed, the height of fall, and the fluid properties. As the buoyancy increases, the system bifurcates from “forced” folding driven kinematically by fluid extrusion to “free” folding in which viscous resistance to bending is balanced by buoyancy. The systematics of the numerically predicted folding frequency are in good agreement with laboratory experiments.

  5. Curved Folded Plate Timber Structures


    Buri, Hans Ulrich; Stotz, Ivo; Weinand, Yves


    This work investigates the development of a Curved Origami Prototype made with timber panels. In the last fifteen years the timber industry has developed new, large size, timber panels. Composition and dimensions of these panels and the possibility of milling them with Computer Numerical Controlled machines shows great potential for folded plate structures. To generate the form of these structures we were inspired by Origami, the Japanese art of paper folding. Common paper tessellations are c...

  6. Exhumation of the North Alpine Foreland Basin- Quantitative insights from structural analysis, thermochronology and a new thermal history model (United States)

    Luijendijk, Elco; von Hagke, Christoph; Hindle, David


    Due to a wealth of geological and thermochronology data the northern foreland basin of the European Alps is an ideal natural laboratory for understanding the dynamics of foreland basins and their interaction with surface and geodynamic processes. We present an unprecedented compilation of thermochronological data from the basin and quantify cooling and exhumation rates in the basin by combining published and new vitrinite reflectance, apatite fission track and U-Th/He data with a new inverse burial and thermal history model. No correlation is obvious between inferred cooling and exhumation rates and elevation, relief or tectonics. We compare derived temperature histories to exhumation estimates based on the retro-deformation of Molasse basin and the Jura mountains, and to exhumation caused by drainage reorganization and incision. Drainage reorganization can explain at most 25% of the observed cooling rates in the basin. Tectonic transport of the basin's sediments over the inclined basement of the alpine foreland as the Jura mountains shortened can explain part of the cooling signal in the western part of the basin. However, overall a substantial amount of cooling and exhumation remains unexplained by known tectonic and surface processes. Our results document basin wide exhumation that may be related to slab roll-back or other lithospheric processes. Uncertainty analysis shows that thermochronometers can be explained by cooling and exhumation starting as early as the Miocene or as late as the Pleistocene. New (U-Th)/He data from key areas close to the Alpine front may provide better constraints on the timing of exhumation.

  7. Observations of paraglacial processes on glacier forelands in Aoraki/Mount Cook National Park, Southern Alps, New Zealand (United States)

    Winkler, Stefan


    The large and extensively debris-covered valley glaciers in Aoraki/Mount Cook National Park immediate east of the Main Divide in the Southern Alps of New Zealand experienced a substantial frontal retreat and vertical downwasting during the past few decades, often connected with the development of a proglacial lake and retreat by calving. Their Holocene glacier forelands are characterised by huge lateral moraines and multi-ridged lateral moraine systems alongside smaller terminal moraines and frontal outwash heads. Placed within a very dynamic general geomorphological regime of various efficient process-systems, these Holocene glacier forelands are currently affected by substantial paraglacial modification. These paraglacial processes have already caused some consequences for the touristic infrastructure in the area and are likely to cause further problems for the accessibility of established tramping routes, tourist huts, and lookouts in the near and medium future. One of the first steps in a project under development presented here is a detailed visual comparison of changes documented during the past 15 Years on the glacier forelands of Hooker, Mueller and Tasman Glaciers in Aoraki/Mount Cook National Park. It reveals considerable erosion especially on the proximal slopes of the lateral moraines by gully development and retreat of erosion scars at their crest in order of several metres in just a few years. Different processes contribute to high erosion rates, among others rill erosion connected to mid-slope springs that only are temporarily active following substantial rainfall events, efficient gully incision, and slumping. Although any quantification of the actual erosion rates is just preliminary and further studies are necessary in order to make reliable predictions for future development, the amount of paraglacial erosion in this environment is very high compared to other regions and highlights the current importance of the paraglacial process-system in the

  8. Repairing the vibratory vocal fold. (United States)

    Long, Jennifer L


    A vibratory vocal fold replacement would introduce a new treatment paradigm for structural vocal fold diseases such as scarring and lamina propria loss. This work implants a tissue-engineered replacement for vocal fold lamina propria and epithelium in rabbits and compares histology and function to injured controls and orthotopic transplants. Hypotheses were that the cell-based implant would engraft and control the wound response, reducing fibrosis and restoring vibration. Translational research. Rabbit adipose-derived mesenchymal stem cells (ASC) were embedded within a three-dimensional fibrin gel, forming the cell-based outer vocal fold replacement (COVR). Sixteen rabbits underwent unilateral resection of vocal fold epithelium and lamina propria, as well as reconstruction with one of three treatments: fibrin glue alone with healing by secondary intention, replantation of autologous resected vocal fold cover, or COVR implantation. After 4 weeks, larynges were examined histologically and with phonation. Fifteen rabbits survived. All tissues incorporated well after implantation. After 1 month, both graft types improved histology and vibration relative to injured controls. Extracellular matrix (ECM) of the replanted mucosa was disrupted, and ECM of the COVR implants remained immature. Immune reaction was evident when male cells were implanted into female rabbits. Best histologic and short-term vibratory outcomes were achieved with COVR implants containing male cells implanted into male rabbits. Vocal fold cover replacement with a stem cell-based tissue-engineered construct is feasible and beneficial in acute rabbit implantation. Wound-modifying behavior of the COVR implant is judged to be an important factor in preventing fibrosis. NA. Laryngoscope, 128:153-159, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  9. NoFold: RNA structure clustering without folding or alignment. (United States)

    Middleton, Sarah A; Kim, Junhyong


    Structures that recur across multiple different transcripts, called structure motifs, often perform a similar function-for example, recruiting a specific RNA-binding protein that then regulates translation, splicing, or subcellular localization. Identifying common motifs between coregulated transcripts may therefore yield significant insight into their binding partners and mechanism of regulation. However, as most methods for clustering structures are based on folding individual sequences or doing many pairwise alignments, this results in a tradeoff between speed and accuracy that can be problematic for large-scale data sets. Here we describe a novel method for comparing and characterizing RNA secondary structures that does not require folding or pairwise alignment of the input sequences. Our method uses the idea of constructing a distance function between two objects by their respective distances to a collection of empirical examples or models, which in our case consists of 1973 Rfam family covariance models. Using this as a basis for measuring structural similarity, we developed a clustering pipeline called NoFold to automatically identify and annotate structure motifs within large sequence data sets. We demonstrate that NoFold can simultaneously identify multiple structure motifs with an average sensitivity of 0.80 and precision of 0.98 and generally exceeds the performance of existing methods. We also perform a cross-validation analysis of the entire set of Rfam families, achieving an average sensitivity of 0.57. We apply NoFold to identify motifs enriched in dendritically localized transcripts and report 213 enriched motifs, including both known and novel structures. © 2014 Middleton and Kim; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  10. Digital geologic map of the Thirsty Canyon NW quadrangle, Nye County, Nevada (United States)

    Minor, S.A.; Orkild, P.P.; Sargent, K.A.; Warren, R.G.; Sawyer, D.A.; Workman, J.B.


    This digital geologic map compilation presents new polygon (i.e., geologic map unit contacts), line (i.e., fault, fold axis, dike, and caldera wall), and point (i.e., structural attitude) vector data for the Thirsty Canyon NW 7 1/2' quadrangle in southern Nevada. The map database, which is at 1:24,000-scale resolution, provides geologic coverage of an area of current hydrogeologic and tectonic interest. The Thirsty Canyon NW quadrangle is located in southern Nye County about 20 km west of the Nevada Test Site (NTS) and 30 km north of the town of Beatty. The map area is underlain by extensive layers of Neogene (about 14 to 4.5 million years old [Ma]) mafic and silicic volcanic rocks that are temporally and spatially associated with transtensional tectonic deformation. Mapped volcanic features include part of a late Miocene (about 9.2 Ma) collapse caldera, a Pliocene (about 4.5 Ma) shield volcano, and two Pleistocene (about 0.3 Ma) cinder cones. Also documented are numerous normal, oblique-slip, and strike-slip faults that reflect regional transtensional deformation along the southern part of the Walker Lane belt. The Thirsty Canyon NW map provides new geologic information for modeling groundwater flow paths that may enter the map area from underground nuclear testing areas located in the NTS about 25 km to the east. The geologic map database comprises six component ArcINFO map coverages that can be accessed after decompressing and unbundling the data archive file (tcnw.tar.gz). These six coverages (tcnwpoly, tcnwflt, tcnwfold, tcnwdike, tcnwcald, and tcnwatt) are formatted here in ArcINFO EXPORT format. Bundled with this database are two PDF files for readily viewing and printing the map, accessory graphics, and a description of map units and compilation methods.

  11. Late Burdigalian sea retreat from the North Alpine Foreland Basin: new magnetostratigraphic age constraints (United States)

    Sant, K.; Kirscher, U.; Reichenbacher, B.; Pippèrr, M.; Jung, D.; Doppler, G.; Krijgsman, W.


    Accurate reconstruction of the final sea retreat from the North Alpine Foreland Basin (NAFB) during the Burdigalian (Early Miocene) is hampered by a lack of reliable age constraints. In this high resolution magnetostratigraphic study we try to solve a significant age bias for the onset of the Upper Freshwater Molasse (OSM) deposition in the neighboring S-German and Swiss Molasse Basins. We measured > 550 samples from eleven drill cores covering the transition from marine to brackish to freshwater environments in the S-German Molasse Basin. Based on combined bio-, litho- and magnetostratigraphic constraints, the composite magnetostratigraphic pattern of these cores provides two reasonable age correlation options (model 1 and 2). In model 1, the base of the brackish succession lies within Chron C5Cr ( 16.7-17.2 Ma), and the onset of OSM deposition has an age of 16.5 Ma. Correlation model 2 suggests the transition to brackish conditions to be within C5Dr.1r ( 17.7-17.5 Ma), and yields an age around 16.7 Ma for the shift to the OSM. Most importantly, both models confirm a much younger age for the OSM base in the study area than previously suggested. Our results demonstrate a possible coincidence of the last transgressive phase (Kirchberg Fm) with the Miocene Climatic Optimum (model 1), or with the onset of this global warming event (model 2). In contrast, the final retreat of the sea from the study area is apparently not controlled by climate change. Supplementary material B. Profiles of the eleven studied drill cores including lithologies, all magnetostratigraphic data (inclinations), interpreted polarity pattern (this study and Reichenbacher et al., 2013) and magnetic susceptibility (this study). Legend for graphs on page 1. Samples without a stable direction above 200 °C or 20 mT are depicted as +-signs and plotted at 0° inclination. The interpreted normal (black), reversed (white) and uncertain (grey) polarity zones in the polarity columns are based on at least

  12. Evolution of sedimentary architecture in retro-foreland basin: Aquitaine basin example from Paleocene to lower Eocene. (United States)

    Ortega, Carole; Lasseur, Eric; Guillocheau, François; Serrano, Olivier; Malet, David


    The Aquitaine basin located in south western Europe, is a Pyrenean retro-foreland basin. Two main phases of compression are recorded in this retro-foreland basin during the Pyrenean orogeny. A first upper Cretaceous phase corresponding to the early stage of the orogeny, and a second one usually related to a Pyrenean paroxysmal phase during the middle Eocene. During Paleocene to lower Eocene deformations are less pronounced, interpreted as a tectonically quiet period. The aim of the study is to better constrain the sedimentary system of the Aquitaine basin during this period of Paleocene-lower Eocene, in order to discuss the evolution of the sedimentary architecture in response of the Pyrenean compression. This work is based on a compilation of a large set of subsurface data (wells logs, seismic lines and cores logs) represented by isopachs and facies map. Three main cycles were identified during this structural quiet period: (1) The Danian cycle, is recorded by the aggradation of carbonate reef-rimmed platform. This platform is characterized by proximal facies (oncoid carbonate and mudstone with thalassinoides) to the north, which leads to distal deposit facies southern (pelagic carbonate with globigerina and slump facies) and present a significant thickness variation linked to the platform-slope-basin morphology. (2) The upper Selandian-Thanetian cycle follows a non-depositional/erosional surface associated with a Selandian hiatus. The base of this cycle marked the transition between the last reef rimmed platform and a carbonate ramp. The transgressive cycle is characterized by proximal lagoon facies to the north that leads southward to distal hemipelagic facies interfingered by turbiditic Lowstand System Tracks (LST). The location of these LST is strongly controlled by inherited Danian topography. The regressive cycle ends with a major regression associated with an erosional surface. This surface is linked with a network of canyons in the north, an important

  13. The four-fold way

    International Nuclear Information System (INIS)

    Terazawa, H.


    The four-fold way is proposed in a minimal composite model of quarks and leptons. Various new pictures and consequences are presented and discussed. They include 1) generation, 2) quark-lepton mass spectrum, 3) quark mixing, 4) supersymmetry, 5) effective gauge theory. (author)

  14. Late Cenozoic basin evolution and fold-thrust deformation in the southern Central Andes: Initial constraints from synorogenic deposits of the Precordillera, Argentina (United States)

    Levina, M.; Horton, B. K.; Fuentes, F.; Stockli, D. F.


    In the Precordillera region of the Argentine Andes, Cenozoic shortening associated with flattening of the Pampean segment of the subducting Nazca plate has resulted in a series of thin skinned fold-thrust systems that partitioned and uplifted Cenozoic foreland basin deposits. The kinematic and temporal evolution of the Andean Precordillera can be approached through detailed analyses of the sedimentary fill now preserved in intermontane regions and the bedrock low-temperature thermochronology of the fold-thrust belt. In this project, we focus on Neogene foreland basin fill exposed in the central and eastern Precordillera along the San Juan River (Quebrada Albarracín and Pachaco regions), on the western flank of the Sierra Talacasto, and in the Loma de las Tapias area near the Ullum dam. The sedimentary successions exposed in these regions record the hinterland development of the Frontal Cordillera (detrital zircon provenance and composition of sandstone and conglomeratic units), regional volcanism (pyroclastic flows and tuffaceous sandstone units), and initial construction of the Precordillera (fault cutoff relationships, growth strata, and paleocurrent changes). We investigate the development and subsequent partitioning and deformation of these synorogenic sections using sediment provenance (detrital zircon U-Pb geochronology, conglomerate clast counts, sandstone petrography, and paleocurrent measurements), facies analysis of measured stratigraphic successions, and initial apatite (U-Th)/He cooling histories to constrain the age of uplift-induced exhumation of successive thrust sheets in the Andean Precordillera.

  15. Characterization of gold mineralization in Garin Hawal area, Kebbi State, NW Nigeria, using remote sensing

    Directory of Open Access Journals (Sweden)

    Talaat M. Ramadan


    Full Text Available Garin Hawal area, Kebbi State, NW Nigeria is part of the Neoproterozoic to Early Phanerozoic terrane separating the west African and Congo Cratons. Three main gold-bearing shear zones were detected in the study area from the processed Landsat ETM+ images and extensive ground investigation. Field and petrographical studies indicate that the Neoproterozoic rocks are represented by a highly folded and faulted belt constituted of hornblende, muscovite and graphite schist. They are intruded by granondiorites and late to post granitic dykes. Extensive alteration zones were identified using high resolution QuickBird image along Garin Hawal shear zone. The alteration zones and associated quartz veins are generally concordant with the main NE–SW regional structural trend and are dipping to the NW. Geochemical studies indicate that the gold content reaches 8 g/t in the alteration zones, while it reaches up to 35 g/t in the quartz veins. Mineralogical studies indicate that the alterations are strongly potassium-enriched. Pyrophyllite, kaolinite, illite, gypsum and quartz also occur. The main ore minerals are gold, chalcopyrite, arsenopyrite, pyrite, galena and iron oxides. This study indicates that the alteration zones and the associated quartz veins in the muscovite schist are promising and need more detailed exploration for Au and Ag mineralization to evaluate their potential.

  16. Structural analysis of sheath folds in the Sylacauga Marble Group, Talladega slate belt, southern Appalachians (United States)

    Mies, J.W.


    Remnant blocks of marble from the Moretti-Harrah dimension-stone quarry provide excellent exposure of meter-scale sheath folds. Tubular structures with elliptical cross-sections (4 ???Ryz ??? 5) are the most common expression of the folds. The tubes are elongate subparallel to stretching lineation and are defined by centimeter-scale layers of schist. Eccentrically nested elliptical patterns and opposing asymmetry of folds ('S' and 'Z') are consistent with the sheath-fold interpretation. Sheath folds are locally numerous in the Moretti-Harrah quarry but are not widely distributed in the Sylacauga Marble Group; reconnaissance in neighboring quarries provided no additional observations. The presence of sheath folds in part of the Talladega slate belt indicates a local history of plastic, non-coaxial deformation. Such a history of deformation is substantiated by petrographic study of an extracted hinge from the Moretti-Harrah quarry. The sheath folds are modeled as due to passive amplification of initial structures during simple shear, using both analytic geometry and graphic simulation. As indicated by these models, relatively large shear strains (y ??? 9) and longitudinal initial structures are required. The shear strain presumably relates to NW-directed displacement of overlying crystalline rocks during late Paleozoic orogeny. ?? 1993.

  17. Role of tectonic inheritance in the instauration of Tunisian Atlassic fold-and-thrust belt: Case of Bouhedma - Boudouaou structures (United States)

    Ghanmi, Mohamed Abdelhamid; Ghanmi, Mohamed; Aridhi, Sabri; Ben Salem, Mohamed Sadok; Zargouni, Fouad


    Tectonic inversion in the Bouhedma-Boudouaou Mountains was investigated through recent field work and seismic lines interpretation calibrated with petroleum well data. Located to the Central-Southern Atlas of Tunisia, this area signed shortened intra-continental fold-and-thrust belts. Two dissymmetric anticlines characterize Bouhedma - Boudouaou major fold. These structures show a strong virgation respectively from E-W to NNE-SSW as a response to the interference between both tectonic inversion and tectonic inheritance. This complex geometry is driven by Mesozoic rifting, which marked an extensional inherited regime. A set of late Triassic-Early Jurassic E-W and NW-SE normal faults dipping respectively to the North and to the East seems to widely affect the overall geodynamic evolution of this domain. They result in major thickness changes across the hanging wall and the footwall blocks in response with the rifting activity. Tectonic inversion is inferred from convergence between African and European plates since late Cretaceous. During Serravalian - Tortonian event, NW-SE trending paroxysm led to: 1) folding of pre-inversion and syn-inversion strata, 2) reactivation of pre-existing normal faults to reverse ones and 3) orogeny of the main structures with NE-SW and E-W trending. The compressional feature still remains active during Quaternary event (Post-Villafranchian) with N-S trending compression. Contraction during inversion generates folding and internal deformation as well as Fault-Propagation-Fold and folding related strike.

  18. NW-MILO Acoustic Data Collection

    Energy Technology Data Exchange (ETDEWEB)

    Matzner, Shari; Myers, Joshua R.; Maxwell, Adam R.; Jones, Mark E.


    There is an enduring requirement to improve our ability to detect potential threats and discriminate these from the legitimate commercial and recreational activity ongoing in the nearshore/littoral portion of the maritime domain. The Northwest Maritime Information and Littoral Operations (NW-MILO) Program at PNNL’s Coastal Security Institute in Sequim, Washington is establishing a methodology to detect and classify these threats - in part through developing a better understanding of acoustic signatures in a near-shore environment. The purpose of the acoustic data collection described here is to investigate the acoustic signatures of small vessels. The data is being recorded continuously, 24 hours a day, along with radar track data and imagery. The recording began in August 2008, and to date the data contains tens of thousands of signals from small vessels recorded in a variety of environmental conditions. The quantity and variety of this data collection, with the supporting imagery and radar track data, makes it particularly useful for the development of robust acoustic signature models and advanced algorithms for signal classification and information extraction. The underwater acoustic sensing system is part of a multi-modal sensing system that is operating near the mouth of Sequim Bay. Sequim Bay opens onto the Straight of Juan de Fuca, which contains part of the border between the U.S. and Canada. Table 1 lists the specific components used for the NW-MILO system. The acoustic sensor is a hydrophone permanently deployed at a mean depth of about 3 meters. In addition to a hydrophone, the other sensors in the system are a marine radar, an electro-optical (EO) camera and an infra-red (IR) camera. The radar is integrated with a vessel tracking system (VTS) that provides position, speed and heading information. The data from all the sensors is recorded and saved to a central server. The data has been validated in terms of its usability for characterizing the

  19. The Emilia 2012 seismic sequence: hints on incipient basement-involved deformation in the foreland of the Northern Apennines (Italy) (United States)

    Argnani, Andrea; Carannante, Simona; Massa, Marco; D'Alema, Ezio; Lovati, Sara


    The deformation front of the Northern Apennines is buried under the sediments of the Po Plain and was formed mainly during the Pliocene. The remarkably arcuate shape of the thrust front contrasts with the linear northwestern trend of the pede-Apennines, where recent deformation is documented by both geological and geodetic evidence. This study presents new geological and seismological data that are used to assess the structural style of the Ferrara Arc, a sector of the Northern Apennine front that was hit by two strong earthquakes on May 20 (MW 6.1) and May 29 (MW 6.0), 2012. The proposed interpretation is based on a dense grid of commercial seismic profiles and exploration wells, and high-quality relocation of ~5,300 earthquakes (the Emilia sequence). The seismicity was used to calibrate new one-dimensional and three-dimensional local Vp and Vs velocity models for the area. On the basis of these new models, the initial sparse hypocenters were then relocated in absolute mode and adjusted using the double-difference relative location algorithm. Seismicity distribution is elongated in the W-NW to E-SE directions, reaching a depth of 10-12 km. The aftershocks of the May 20 mainshock appear to be distributed on a rupture surface that dips ~45° SSW, and the surface projection indicates an area ~10 km wide and 23 km long. The aftershocks of the May 29 second mainshock followed a steep rupture surface that is well constrained within the investigated volume, whereby the surface projection of the blind source indicates an area ~6 km wide and 33 km long. The analysed multichannel seismic profiles highlight the presence of relevant lateral variations in the structural style of the Ferrara folds that developed during the Pliocene and Pleistocene, and also show the occurrence of a Mesozoic extensional fault system in the Ferrara arc, which in places has been seismically reactivated. These geological and seismological observations suggest that the 2012 Emilia earthquakes were

  20. Mercury concentrations in cattle from NW Spain. (United States)

    López Alonso, M; Benedito, J L; Miranda, M; Castillo, C; Hernández, J; Shore, R F


    Mercury is a toxic metal that is released into the environment as a result of various industrial and agricultural processes. It can be accumulated by domestic animals and so contaminate human foodstuffs. To date, there is no information on mercury residues in livestock in Spain and the aim of the present study was to quantify the concentrations of mercury in cattle in two of the major regions in north-west Spain, Galicia (a largely rural region) and Asturias, which is characterised by heavy industry and mining. Total mercury concentrations were determined in tissue (liver, kidney and muscle) and blood from 284 calves (6-10 months old) and 56 cows (2-16 years old) from across the whole of the two regions. Mercury was usually detected in the kidney (62.4-87.5% of samples) but most (79.5-96%) liver, muscle and blood samples did not contain detectable residues. Renal mercury concentrations did not differ between male and female calves but were significantly greater in female calves than in cows. Unexpectedly, kidney mercury concentrations were significantly higher in calves from the predominantly rural region of Galicia (geometric mean: 12.2 microg/kg w.wt.) than in animals from the industrialised-mining region of Asturias (3.40 microg/kg w.wt.). Overall, mercury residues in cattle from NW Spain were similar to those reported in cattle from non-polluted areas in other countries and do not constitute a risk to animal or human health. Copyright 2002 Elsevier Science B.V.

  1. Morphotectonic aspects of active folding in Zagros Mountains (Fin, SE of Iran) (United States)

    Roustaei, M.; Abbasi, M.


    Active deformation in Iran, structural province of Zagros is a result of the convergence between the Arabian & Eurasian plates. The Zagros Mountains in southern Iran are one of the seismically active region & is introduced as fold-thrust belt trending NW-SE within the Arabian plate. Fin lies in Hormozgan province; the south of Iran. The vastness is surrounded by central Iran in the north, High Zagros in the North West and west, Folded Zagros in the east, Makran in the south east and Persian Gulf in the south. The study area is determined by complex structures, alternation of folding, salt diapers and faulting. The surface geology mainly comprises Neogene; Marls, Conglomerate, Sandstones (Mishan, Aghajari, Bakhtiyari formations), old fans and alluvium as syncline that Shur River cuts its north limb and passes from the middle of core .The older formations( Ghachsaran, Rzak and Guri member) folded into prominent anticlines. The fold axes mostly follow the parallel trends .Folds trending are NW-SE (Tashkend anticline), NE-SW (Khur anticline), E-W (Guniz & Handun anticline) and the trend of axes Baz fold in the main part is E-W. Hormoz salt also outcrops in the cores of many whaleback anticlines. Thus, anticlines may be cored with evaporates, even though no salt is currently exposed at the surface. Reason of selecting this area as an example referred to active seismcity. Release of energy is gradually in every events, this seismic character cusses that there was not earthquake with high magnitude in the area but it can not be a role. Answer to the question concerning relationship between folding of the crust layer and faulting at depth is more difficult. There is 2 terms to describe this relationship; "detachment folds" and" forced folds". In this paper, we try to analysis of different satellite imagery; Aster, spot and digital elevation model with high resolution (10 m) in order to detect geomorphic indicators which can help us to find a relationship between faulting

  2. Implications of heterogeneous fracture distribution on reservoir quality; an analogue from the Torridon Group sandstone, Moine Thrust Belt, NW Scotland (United States)

    Watkins, Hannah; Healy, David; Bond, Clare E.; Butler, Robert W. H.


    Understanding fracture network variation is fundamental in characterising fractured reservoirs. Simple relationships between fractures, stress and strain are commonly assumed in fold-thrust structures, inferring relatively homogeneous fracture patterns. In reality fractures are more complex, commonly appearing as heterogeneous networks at outcrop. We use the Achnashellach Culmination (NW Scotland) as an outcrop analogue to a folded tight sandstone reservoir in a thrust belt. We present fracture data is collected from four fold-thrust structures to determine how fracture connectivity, orientation, permeability anisotropy and fill vary at different structural positions. We use a 3D model of the field area, constructed using field observations and bedding data, and geomechanically restored using Move software, to determine how factors such as fold curvature and strain influence fracture variation. Fracture patterns in the Torridon Group are consistent and predictable in high strain forelimbs, however in low strain backlimbs fracture patterns are inconsistent. Heterogeneities in fracture connectivity and orientation in low strain regions do not correspond to fluctuations in strain or fold curvature. We infer that where strain is low, other factors such as lithology have a greater control on fracture formation. Despite unpredictable fracture attributes in low strain regions, fractured reservoir quality would be highest here because fractures in high strain forelimbs are infilled with quartz. Heterogeneities in fracture attribute data on fold backlimbs mean that fractured reservoir quality and reservoir potential is difficult to predict.

  3. Tectonics vs. Climate efficiency in triggering detrital input in sedimentary basins: the Po Plain-Venetian-Adriatic Foreland Basin (Northern Italy) (United States)

    Amadori, Chiara; Di Giulio, Andrea; Toscani, Giovanni; Lombardi, Stefano; Milanesi, Riccardo; Panara, Yuri; Fantoni, Roberto


    The relative efficiency of tectonics respect to climate in triggering erosion of mountain belts is a classical but still open debate in geosciences. The fact that data both from tectonically active and inactive mountain regions in different latitudes, record a worldwide increase of sediment input to sedimentary basins during the last million years concomitantly with the cooling of global climate and its evolution toward the modern high amplitude oscillating conditions pushed some authors to conclude that Pliocene-Pleistocene climate has been more efficient than tectonics in triggering mountain erosion. Po Plain-Venetian-Adriatic Foreland System, made by the relatively independent Po Plain-Northern Adriatic Basin and Venetian-Friulian Basin, provides an ideal case of study to test this hypothesis and possibly quantify the difference between the efficiency of the two. In fact it is a relatively closed basin (i.e. without significant sediment escape) with a fairly continuous sedimentation (i.e. with a quite continuous sedimentary record) completely surrounded by collisional belts (Alps, Northern Apennines and Dinarides) that experienced only very weak tectonic activity since Calabrian time, i.e. when climate cooling and cyclicity increased the most. We present a quantitative reconstruction of the sediment flow delivered from the surrounding mountain belts to the different part of the basin during Pliocene-Pleistocene time. This flow was obtained through the 3D reconstruction of the Venetian-Friulian and Po Plain Northern Adriatic Basins architecture, performed by means of the seismic-based interpretation and time-to-depth conversion of six chronologically constrained surfaces (seismic and well log data from courtesy of ENI); moreover, a 3D decompaction of the sediment volume bounded by each couple of surfaces has been included in the workflow, in order to avoid compaction-related bias. The obtained results show in both Basins a rapid four-folds increase of the

  4. Provenance and geochronological insights into Late Cretaceous-Paleogene foreland basin development in the Subandean Zone and Oriente Basin of Ecuador (United States)

    Gutierrez, E. G.; Horton, B. K.; Vallejo, C.


    The tectonic history of the Oriente foreland basin and adjacent Subandean Zone of Ecuador during contractional mountain building in the northern Andes can be revealed through integrated stratigraphic, geochronological, structural, and provenance analyses of clastic sediments deposited during orogenesis. We present new maximum depositional ages and a comprehensive provenance analysis for key stratigraphic units deposited in the western (proximal) Oriente Basin. Detrital zircon U-Pb ages were obtained from Upper Cretaceous and Cenozoic clastic formations from exposures in the Subandean Zone. The sampled stratigraphic intervals span critical timeframes during orogenesis in the Ecuadorian Andes. Cenozoic formations have poorly defined chronostratigraphic relationships and are therefore a primary target of this study. In addition, the newly acquired U-Pb age spectra allow clear identification of the various sediment source regions that fed the system during distinct depositional phases. Maximum depositional ages (MDA) were obtained for five samples from three formations: the Tena (MDA=69.6 Ma), Chalcana (MDA=29.3 Ma), and Arajuno (MDA= 17.1, 14.2, 12.8 Ma) Formations, placing them in the Maastrichtian, early Oligocene, and early-middle Miocene, respectively. Detrital zircon U-Pb ages identify clear signatures of at least four different sources: craton (1600-1300 Ma, 1250-900 Ma), Eastern Cordillera fold-thrust belt (600-450 Ma, 250-145 Ma), Western Cordillera magmatic arc (age spectra of the Upper Cretaceous-Paleogene type sections allow us to recognize variations in the contribution of each recognized source over time. We identify recycled material with two dominant peak ages (1250-900 Ma and 600-450 Ma), material derived from the adjacent uplifted orogen or recycled from foredeep sediments incorporated into the deforming wedge. Finally, an apparent unroofing event is inferred from a 250-145 Ma age peak in the Plio-Pleistocene Mesa-Mera Formation revealing the

  5. Force generation by titin folding. (United States)

    Mártonfalvi, Zsolt; Bianco, Pasquale; Naftz, Katalin; Ferenczy, György G; Kellermayer, Miklós


    Titin is a giant protein that provides elasticity to muscle. As the sarcomere is stretched, titin extends hierarchically according to the mechanics of its segments. Whether titin's globular domains unfold during this process and how such unfolded domains might contribute to muscle contractility are strongly debated. To explore the force-dependent folding mechanisms, here we manipulated skeletal-muscle titin molecules with high-resolution optical tweezers. In force-clamp mode, after quenching the force (force trace contained rapid fluctuations and a gradual increase of average force, indicating that titin can develop force via dynamic transitions between its structural states en route to the native conformation. In 4 M urea, which destabilizes H-bonds hence the consolidated native domain structure, the net force increase disappeared but the fluctuations persisted. Thus, whereas net force generation is caused by the ensemble folding of the elastically-coupled domains, force fluctuations arise due to a dynamic equilibrium between unfolded and molten-globule states. Monte-Carlo simulations incorporating a compact molten-globule intermediate in the folding landscape recovered all features of our nanomechanics results. The ensemble molten-globule dynamics delivers significant added contractility that may assist sarcomere mechanics, and it may reduce the dissipative energy loss associated with titin unfolding/refolding during muscle contraction/relaxation cycles. © 2017 The Protein Society.

  6. Temperature sensitivity of extreme precipitation events in the south-eastern Alpine forelands (United States)

    Schroeer, Katharina; Kirchengast, Gottfried


    How will convective precipitation intensities and patterns evolve in a warming climate on a regional to local scale? Studies on the scaling of precipitation intensities with temperature are used to test observational and climate model data against the hypothesis that the change of precipitation with temperature will essentially follow the Clausius-Clapeyron (CC) equation, which corresponds to a rate of increase of the water holding capacity of the atmosphere by 6-7 % per Kelvin (CC rate). A growing number of studies in various regions and with varying approaches suggests that the overall picture of the temperature-precipitation relationship is heterogeneous, with scaling rates shearing off the CC rate in both upward and downward directions. In this study we investigate the temperature scaling of extreme precipitation events in the south-eastern Alpine forelands of Austria (SEA) based on a dense rain gauge net of 188 stations, with sub-daily precipitation measurements since about 1990 used at 10-min resolution. Parts of the study region are European hot-spots for severe hailstorms and the region, which is in part densely populated and intensively cultivated, is generally vulnerable to climate extremes. Evidence on historical extremely heavy short-time and localized precipitation events of several hundred mm of rain in just a few hours, resulting in destructive flash flooding, underline these vulnerabilities. Heavy precipitation is driven by Mediterranean moisture advection, enhanced by the orographic lifting at the Alpine foothills, and hence trends in positive sea surface temperature anomalies might carry significant risk of amplifying future extreme precipitation events. In addition, observations from the highly instrumented subregion of south-eastern Styria indicate a strong and robust long-term warming trend in summer of about 0.7°C per decade over 1971-2015, concomitant with a significant increase in the annual number of heat days. The combination of these

  7. Multidisciplinary insights into the seismotectonics of the Swiss Alps and its foreland (United States)

    Diehl, Tobias; Lee, Timothy; Houlié, Nicolas; Cardello, Giovanni Luca; Kraft, Toni; Clinton, John; Kissling, Edi; Wiemer, Stefan


    Information on structure and mechanics of fault systems and their connection with present-day seismicity is key to the understanding of neotectonic processes in the Swiss Alps and the northern Swiss Foreland. Precisely determined focal depths in combination with high-resolution structural models can provide important insight into deformation styles of the uppermost crust (e.g. thin- vs. versus thick-skinned tectonics). Detailed images of seismogenic fault zones combined with estimates on deformation rates from geodesy, on the other hand, will improve the assessment of the hazard related to natural and induced earthquakes in those regions. In the framework of various projects, studies have been recently undertaken to image seismogenic fault zones at high resolution, with a special focus on southwest and northeast Switzerland because of their high societal relevance. Southwest Switzerland, is the region with one of the highest natural seismic hazard in the country. A large part of the present-day seismic activity is related to an earthquake lineament located in the southern part of the Rawil depression, which is dominated by strike-slip faulting. The possibility of large magnitude earthquakes critically depends on the question as to whether this activity is related to a single fault of considerable lateral and vertical extension or not. Field data demonstrate oblique normal faulting and fault segmentation at surface related to mountain uplift at the curvature of the Alpine Arc. Studies of seismogenic structures and neotectonic processes in the northeast Molasse basin, on the other hand, are of special interest, since the region is one of the target sites for radioactive waste repositories and future geothermal plants. On-going densification of the seismic network in Switzerland and new detection algorithms have significantly lowered the detection threshold of microearthquakes and improved data coverage in most parts of the country over the last ten years. To

  8. Synovial folds in equine articular process joints

    DEFF Research Database (Denmark)

    Thomsen, Line Nymann; Berg, Lise Charlotte; Markussen, Bo


    Cervical synovial folds have been suggested as a potential cause of neck pain in humans. Little is known about the extent and characteristics of cervical synovial folds in horses.......Cervical synovial folds have been suggested as a potential cause of neck pain in humans. Little is known about the extent and characteristics of cervical synovial folds in horses....

  9. Crustal Structure of the Andean Foreland in Northern Argentina: Results From Data-Integrative Three-Dimensional Density Modeling (United States)

    Meeßen, C.; Sippel, J.; Scheck-Wenderoth, M.; Heine, C.; Strecker, M. R.


    Previous thermomechanical modeling studies indicated that variations in the temperature and strength of the crystalline crust might be responsible for the juxtaposition of domains with thin-skinned and thick-skinned crustal deformation along strike the foreland of the central Andes. However, there is no evidence supporting this hypothesis from data-integrative models. We aim to derive the density structure of the lithosphere by means of integrated 3-D density modeling, in order to provide a new basis for discussions of compositional variations within the crust and for future thermal and rheological modeling studies. Therefore, we utilize available geological and geophysical data to obtain a structural and density model of the uppermost 200 km of the Earth. The derived model is consistent with the observed Bouguer gravity field. Our results indicate that the crystalline crust in northern Argentina can be represented by a lighter upper crust (2,800 kg/m3) and a denser lower crust (3,100 kg/m3). We find new evidence for high bulk crustal densities >3,000 kg/m3 in the northern Pampia terrane. These could originate from subducted Puncoviscana wackes or pelites that ponded to the base of the crystalline crust in the late Proterozoic or indicate increasing bulk content of mafic material. The precise composition of the northern foreland crust, whether mafic or felsic, has significant implications for further thermomechanical models and the rheological behavior of the lithosphere. A detailed sensitivity analysis of the input parameters indicates that the model results are robust with respect to the given uncertainties of the input data.

  10. Trans-Hudsonian far-field deformation effects in the Rae foreland: An integrated geological-3D magnetic model (United States)

    Percival, J. A.; Tschirhart, V.


    The intracratonic Rae cover sequence, deposited ca. 2.2-1.9 Ga, forms a useful marker for unravelling tectonic events that affected the Archean Rae Province at ca.2.0, 1.9 and 1.85 Ga. Polyphase deformation is recognized within the Rae cover rocks, including the 70 × 10 km Montresor belt, and attributed to distal effects of the ca. 1.85 Ga Trans-Hudson orogeny. In this contribution we explore the 3D geometry and structural history of the Montresor belt, previously considered to be a simple syncline lying unconformably on Archean basement. New geological, geophysical and geochronological results define a more complex history in which lower Montresor units were thrust-imbricated with basement gneisses and metamorphosed to the amphibolite facies. Mid-to upper greenschist facies upper Montresor units, exposed in an open synform, are superficially less deformed. However, using high-resolution aeromagnetic data and distinct magnetic marker units considered proxies for bedding, we constructed a set of forward models to explore the three-dimensional geometry of the belt. The re-analysis outlines a set of pre-synform structures defined by low-angle truncations of the magnetic markers. Geometric relationships indicate the presence of at least three faults at low angles to bedding, interpreted as D1 piggy-back thrusts, and bracketed by available geochronology between 1.924 and 1.87 Ga. D1 strain in the upper Montresor strata is significantly less intense than that further south in Rae cover rocks, consistent with a more distal foreland setting during the Trans-Hudson orogeny. The Montresor belt preserves a record of the Trans-Hudson tectonic style at relatively shallow crustal levels as a result of its foreland setting and structural history including a syn-orogenic extensional detachment event.

  11. Paleomagnetic constraints on the Cenozoic kinematic evolution of the Pamir plateau from the Western Kunlun Shan foreland (United States)

    Li, Zhenyu; Ding, Lin; Lippert, Peter C.; Wei, Honghong


    Thick Cenozoic marine and terrestrial sediments are widely distributed along the perimeter of the Pamir plateau and provide valuable information on the kinematic evolution of the region. Here, we report new biostratigraphic and paleomagnetic results from the piedmont of the Western Kunlun Shan to constrain the magnitude and timing of vertical-axis rotations along the eastern margin of the Pamir. Sampling sites were selected by rock formations and ages, which are based on previous field mapping and on litholostratigraphic and biostratigraphic work presented here. Thermomagnetic analysis, step-wise thermal demagnetization behavior, and positive field tests all suggest that the characteristic remanent magnetization (ChRM) directions most probably have a primary detrital and chemical origin. Our results indicate variable, minor, but in some intervals significant vertical axis rotations with respect to a stable Asian reference frame. This pattern of rotations is similar to paleomagnetic data reported in previously published studies from the Eastern Pamir foreland. In contrast, published paleomagnetic data from the Western Pamir foreland consistently indicate significant CCW rotations within that region. Collectively, these results challenge simple oroclinal bending models for the origin of the Pamir salient, and instead are more consistent with an asymmetric "half-orocline" kinematic model in which the curvature of the Western Pamir is the product of a combination of lithospheric bending of an originally quasi-linear mountain belt and radial thrusting, and the subdued curvature of the eastern edge of the plateau is the result of lateral translation of the Pamir plateau northward past Tibet and Tarim along the Kashgar-Yecheng transfer system. Our results are consistent with activity on the Kashgar-Yecheng transfer system in the Early Miocene.

  12. Geomorphology of the Southwest Coast of County Cork, Ireland: A Look into the Rocks, Folds, and Glacial Scours (United States)

    Bowden, S.; Wireman, R.; Sautter, L.; Beutel, E. K.


    Bathymetric data were collected off the southwest coast of County Cork, Ireland by the joint INFOMAR project between the Marine Institute of Ireland and the Geologic Survey of Ireland. Data were collected using a Kongsberg EM2040 multibeam sonar on the R/V Celtic Voyager, in August and September 2014, and were post-processed with CARIS HIPS and SIPS 8.1 and 9.0 software to create 2D and 3D bathymetric surfaces. From the computer generated images, some of the lithologic formations were relatively aged and observed. The studied regions range in depth from 20 to 118 m, with shallower areas to the northeast. Several large rock outcrops occur, the larger of which shows a vertical rise of nearly 20 m. These outcrops are oriented in a northeast-southwest direction, and exhibit significant bed folding, regional folding, tilted beds, and cross joints. The folds studied are plunging chevron folds. These folds have a northeast-southwest fold axis orthogonal to the cross joints and are older relative to the jointing systems. The NE-SW joints are older than the NW-SE joints due to their correlation with drainage and erosion patterns. Regional folding is the youngest feature due to its superposition on the chevron folding and jointing systems. The interaction of cross jointing and folding is consistent with the geologic history of the area, and creates a unique bathymetry worthy of further study.

  13. Erosion and filling of glacially-overdeepened troughs in the Northern Alpine Foreland as recorded in a deep drill core from Northern Switzerland (United States)

    Dehnert, Andreas; Axel Kemna, Hans; Anselmetti, Flavio; Drescher-Schneider, Ruth; Graf, Hans Rudolf; Lowick, Sally; Preusser, Frank; Züger, Andreas; Furrer, Heinz


    As the major weather divide in Europe, the Alps represent one of the most interesting areas for understanding past climate change and its impact on continental environments. However, our knowledge of the Quaternary environmental history of the region is still rather limited, especially for the time preceding the last glaciation of the Alps. Geological and geophysical studies in the Wehntal, 20 km northwest of Zurich, Switzerland, in 2007 and 2008 have revealed the existence of a glacially overdeepened trough cut into Miocene molasse bedrock, which is today filled with ~90 to 180 m of Pleistocene sediments. In March 2009, a 93.6 m long sediment core (NW09/1) has been drilled east of the famous mammoth-site Niederweningen. This record is one of the very few sites in the northern Alpine Foreland that provides crucial insights into the timing of the erosion and infilling history of pre-Eemian glacially overdeepened troughs and also helps to understand the climate and environmental history. Based on chronological data deduced from the nearby, but shorter, 2007 core and on new multi-proxy data, the NW09/1 record is interpreted as: 4.1 m of in-situ molasse bedrock, overlain by 3.4 m of diamictic till. These glacial deposits were deposited by a Linth glacier lobe during Marine Isotope Stage (MIS) 6 (Rissian), although, the possibility that an even older glaciation was responsible cannot currently be excluded (e.g. MIS 8, luminescence dating, pollen interpretations, and palaeomagnetic studies in progress). It is suggested that this extensive ice advance, which once covered the entire Wehntal valley, caused the final erosion of the bedrock. The till is overlain by a 29.5 m thick sequence of laminated, carbonate-rich, fine-grained siliciclastic sediments that are interpreted as proglacial lake sediments. It is supposed that this unit was deposited in a proximal setting to a calving glacier-front confirmed by the presence of numerous dropstones. The damming of this Wehntal

  14. Interaction of the Zagros Fold-Thrust Belt and the Arabian-type, deep-seated folds in the Abadan Plain and the Dezful Embayment, SW Iran

    Energy Technology Data Exchange (ETDEWEB)

    Fard, Iraj Abdollahie [National Iranian Oil Co., Exploration Directorate, Tehran (Iran); Braathen, Alvar [Bergen Univ., Centre for Integrated Petroleum Research, Bergen (Norway); Mokhtari, Mohamad [International Institute of Earthquake Engineering and Seismology, Tehran (Iran); Alavi, Seyed Ahmad [Shahid Beheshti Univ., Earth Sciences Faculty, Tehran (Iran)


    The Dezful Embayment and Abadan Plain (SW Iran) contain major parts of the remaining Iranian oil reserves. These oil provinces are characterized by two types of structural closure: very gentle N-S- to NE-SW-trending basement-cored anticlines (Arabian-type highs) in the SE; and open to tight, NW-SE-trending thrust-related folds in the NE (Zagros Fold-Thrust Belt; ZFTB). Most deep-seated anticlines are upright and symmetrical in Cretaceous and older units. In some cases they reveal steep faults in their core which, in the light of regional observations, suggest that the basement is involved in the faulting. Untested plays around these anticlines include reefal build-ups, debris flows, truncated sedimentary sections and onlapping clastic units. The ZFTB shows a classic structural style, with overall shortening reflected in thrust displacement declining from the Dezful Embayment towards the frontal zone in the Abadan Plain. The Early Cambrian Hormuz Salt represents the fundamental sole for the fold-thrust belt and locates major fault-propagation folds in the southwestern Dezful Embayment. These folds represent the main petroleum target of the area. Another important unit is the Mid-Miocene Gachsaran Formation. This detachment reveals both in-sequence and out-of-sequence thrusting. Interaction of deep-seated anticlines and fold-thrust structures results in thrust imbrications and formation of duplexes within the Gachsaran Formation when thrusts abut deep-seated anticlines. Above the crest of the anticlines, thrusts are forced up-section into syn-tectonic deposits, whereas the forelimb reveals out-of-the-syncline thrusts. Several petroleum plays are identified in such zones of structural interaction, including anticlines above buttress-related duplexes, out-of-sequence imbricate thrust fans with associated folds above major anticlines, truncation of footwall layers below potentially sealing thrusts, and sub-thrust anticlines. (Author)

  15. Quo vadis NW Black Sea benthic ecosystems? (United States)

    Traian Gomoiu, Marian


    / thalasoterapy. Black Sea ecosystem restoration - Certainties and Uncertainties: Pressure on the Danube and other rivers has decreased, chemical discharges have decreased obviously, and yet there appear phenomena of water flowering - "red waters", hypoxia is still present at times and there is mass mortality of fish and other benthic organisms. Why? Signs of recovery should be considered cautiously and uncertainties may be resolved only in a longer time by increasing our scientific efforts. The results of the EU FP7 Project PERSEUS led to the identification of three important issues that should be resolved in order to achieve good environmental status: • Applying an adaptive management to increase the resilience of the ecosystems and to diminish the vulnerability of biodiversity; • Necessity of participative approach by stakeholders; • Identifying and obtaining adequate financial support for new R-D-I projects. Who are the actors in addressing and implementing the actions? • Academic educational and research institutions for adequate working condition; • More specialists trained for taxonomic groups; • Reasonable diversity of coordinating specialists, capable team leaders / satisfactory work packages; • Attracting NGO members towards nature conservation issues; • Resonable stakeholders committed to environmental issues. Studying the results of researches carried out by GeoEcoMar on the Romanian Black Sea coast in recent years, the author concluded that the major problems hampering progress towards a good ecosystem in NW Bent Black Sea are: • lack of diversity in the fields of research, both in theoretical and applied realms; • structural and functional consequences of ecological pressures and the disordered state of the ecosystems in the periods of paroxysmal eutrophication / pollution at the end of the 20th Century; • scarcity of data and knowledge on the Social-Economic System; • high costs of the new marine technology used directly in the sea and

  16. Understanding ensemble protein folding at atomic detail

    International Nuclear Information System (INIS)

    Wallin, Stefan; Shakhnovich, Eugene I


    Although far from routine, simulating the folding of specific short protein chains on the computer, at a detailed atomic level, is starting to become a reality. This remarkable progress, which has been made over the last decade or so, allows a fundamental aspect of the protein folding process to be addressed, namely its statistical nature. In order to make quantitative comparisons with experimental kinetic data a complete ensemble view of folding must be achieved, with key observables averaged over the large number of microscopically different folding trajectories available to a protein chain. Here we review recent advances in atomic-level protein folding simulations and the new insight provided by them into the protein folding process. An important element in understanding ensemble folding kinetics are methods for analyzing many separate folding trajectories, and we discuss techniques developed to condense the large amount of information contained in an ensemble of trajectories into a manageable picture of the folding process. (topical review)

  17. Effects of gravity in folding (United States)

    Minkel, Donald Howe

    Effects of gravity on buckle folding are studied using a Newtonian fluid finite element model of a single layer embedded between two thicker less viscous layers. The methods allow arbitrary density jumps, surface tension coefficients, resistance to slip at the interfaces, and tracking of fold growth to a large amplitudes. When density increases downward in two equal jumps, a layer buckles less and thickens more than with uniform density. When density increases upward in two equal jumps, it buckles more and thickens less. A low density layer with periodic thickness variations buckles more, sometimes explosively. Thickness variations form, even if not present initially. These effects are greater with; smaller viscosities, larger density jump, larger length scale, and slower shortening rate. They also depend on wavelength and amplitude, and these dependencies are described in detail. The model is applied to the explosive growth of the salt anticlines of the Paradox Basin, Colorado and Utah. There, shale (higher density) overlies salt (lower density). Methods for simulating realistic earth surface erosion and deposition conditions are introduced. Growth rates increase both with ease of slip at the salt-shale interface, and when earth surface relief stays low due to erosion and deposition. Model anticlines grow explosively, attaining growth rates and amplitudes close to those of the field examples. Fastest growing wavelengths are the same as seen in the field. It is concluded that a combination of partial-slip at the salt-shale interface, with reasonable earth surface conditions, promotes sufficiently fast buckling of the salt-shale interface due to density inversion alone. Neither basement faulting, nor tectonic shortening is required to account for the observed structures. Of fundamental importance is the strong tendency of gravity to promote buckling in low density layers with thickness variations. These develop, even if not present initially. folds

  18. Protein folding and wring resonances

    DEFF Research Database (Denmark)

    Bohr, Jakob; Bohr, Henrik; Brunak, Søren


    The polypeptide chain of a protein is shown to obey topological contraints which enable long range excitations in the form of wring modes of the protein backbone. Wring modes of proteins of specific lengths can therefore resonate with molecular modes present in the cell. It is suggested that prot......The polypeptide chain of a protein is shown to obey topological contraints which enable long range excitations in the form of wring modes of the protein backbone. Wring modes of proteins of specific lengths can therefore resonate with molecular modes present in the cell. It is suggested...... that protein folding takes place when the amplitude of a wring excitation becomes so large that it is energetically favorable to bend the protein backbone. The condition under which such structural transformations can occur is found, and it is shown that both cold and hot denaturation (the unfolding...

  19. Late Permian rivers draining the uplifted Cape Fold Belt: magnetostratigraphy and detrital thermochronology of Karoo Basin sediments (United States)

    Tohver, E.; Schmieder, M.; Arosio, R.; Lanci, L.; Jourdan, F.; Wilson, A.; Ratcliffe, K.; Payenberg, T.; Flint, S.


    The Cape Fold Belt and Karoo Basin of southern Africa formed during the Permian orogeny that affected the 13,000 km southern margin of the Gondwanan continent. In this report, we synthesize new and recent magnetostratigraphic and geochronologic data to establish a chronostratigraphic framework for Karoo Basin sedimentation for comparison with the thermal/exhumation history of the Cape Fold Belt. The source-sink model is evaluated using new data from detrital muscovite and zircon from 2 km composite section of fluvial sandstone and mudstones deposited at ca.275 - 260 Ma. Coherent age populations of detrital zircon grains indicate rapid incorporation of contemporary volcanic ashbeds into the sedimentary record. In contrast, cooling age distributions of detrital muscovite are typically ca. 5 - 10 Ma older than the age of deposition; similar lag times are observed from modern sediments in active mountain belts. Trace element geochemical signatures demonstrate a clear shift towards crustal recycling via headland erosion in the Beaufort Group relative to the underlying Ecca Group. These observations pinpoint the age of uplift for the Cape Fold Belt, which began to function as the major sediment source for the foreland Karoo Basin with the deposition of the uppermost Ecca Group and basal Beaufort Group.

  20. Distinguishing thrust sequences in gravity-driven fold and thrust belts (United States)

    Alsop, G. I.; Weinberger, R.; Marco, S.


    Piggyback or foreland-propagating thrust sequences, where younger thrusts develop in the footwalls of existing thrusts, are generally assumed to be the typical order of thrust development in most orogenic settings. However, overstep or 'break-back' sequences, where later thrusts develop above and in the hangingwalls of earlier thrusts, may potentially form during cessation of movement in gravity-driven mass transport deposits (MTDs). In this study, we provide a detailed outcrop-based analysis of such an overstep thrust sequence developed in an MTD in the southern Dead Sea Basin. Evidence that may be used to discriminate overstep thrusting from piggyback thrust sequences within the gravity-driven fold and thrust belt includes upright folds and forethrusts that are cut by younger overlying thrusts. Backthrusts form ideal markers that are also clearly offset and cut by overlying younger forethrusts. Portions of the basal detachment to the thrust system are folded and locally imbricated in footwall synclines below forethrust ramps, and these geometries also support an overstep sequence. However, new 'short-cut' basal detachments develop below these synclines, indicating that movement continued on the basal detachment rather than it being abandoned as in classic overstep sequences. Further evidence for 'synchronous thrusting', where movement on more than one thrust occurs at the same time, is provided by displacement patterns on sequences of thrust ramp imbricates that systematically increases downslope towards the toe of the MTD. Older thrusts that initiate downslope in the broadly overstep sequence continue to move and therefore accrue greater displacements during synchronous thrusting. Our study provides a template to help distinguish different thrust sequences in both orogenic settings and gravity-driven surficial systems, with displacement patterns potentially being imaged in seismic sections across offshore MTDs.

  1. Montane pollen from the Tertiary of NW. Borneo

    NARCIS (Netherlands)

    Muller, J.


    In NW. Borneo thick series of Tertiary sediments occur which are rich in fossil pollen and spores. The majority of these plant microfossils were derived from the various types of tropical lowland vegetation such as mangrove (Muller, 1964), mixed peat swamp forest and mixed Dipterocarp forest. Some

  2. Hydrogeology of the basalts in the Uruguayan NW

    International Nuclear Information System (INIS)

    Hausman, A.; Fernandez, A.


    This work is about the hydrogeological aspects in the NW Uruguayan basaltic area. The results of this research are the main geological, morphological and hydrogeological aspects of the area as well as the characteristics and the color of the basalt and sandstones

  3. Palaeofloods and ancient fishing weirs in NW Iberian rivers

    NARCIS (Netherlands)

    Viveen, W.; Sanjurjo-Sanchez, J.; Goy-Dizc, A.; Veldkamp, A.; Schoorl, J.M.


    A 15-m-thick, fluvial sedimentary record of the NW Iberian lower Miño River was studied. Grain-size analyses were performed and twelve samples were dated using optically stimulated luminescence dating techniques, documenting a 1300-yr-old reconstructed fluvial record that does not match with known

  4. Structural analysis of hanging wall and footwall blocks within the Río Guanajibo fold-and-thrust belt in Southwest Puerto Rico (United States)

    Laó-Dávila, Daniel A.; Llerandi-Román, Pablo A.


    The Río Guanajibo fold-and-thrust belt (RGFT), composed of Cretaceous serpentinite and volcano-sedimentary rocks, represents the deformation front of a contractional event in SW Puerto Rico during the Paleogene. Previous studies inferred structural and stratigraphic relationships from poorly exposed outcrops. New road cuts exposed the Yauco (YF) and El Rayo Formations (ERF) providing insights on the deformation of the hanging wall and footwall. We described the nature and orientation of faults and folds and analyzed the kinematic indicators to characterize the deformation. The YF occurs in the hanging wall and shows a sequence of folded, medium-bedded mudstone and thinly bedded shale and sandstone. Major folds strike NW-SE and are gentle with steeply inclined axial planes and sub-horizontal fold axes. Minor folds are open with moderately inclined axial planes and gently to moderately inclined SE-plunging fold axes. NW-SE striking reverse and thrust faults cut layers and show movement to the SW. Steep left-lateral faults strike NW-SE and NE-SW, and smaller right-lateral strike-slip faults strike NNE-SSW. At the footwall, the ERF consists of bioclastic limestone and polymictic orthoconglomerates and paraconglomerates. Reverse and strike-slip faults cut along lithological contacts. Results suggest that the hanging wall and footwall accommodated strain along preexisting weaknesses, which are dependent on lithology and sedimentary structures. The kinematic analysis suggests that shortening in the NE-SW direction was partitioned between folding and interlayer shortening, accommodated by flexural slip, and reverse and left-lateral faults that resulted from contraction. The RGFT represents the Paleogene back arc deformation of a bivergent thrust system.

  5. Evidence for volcanism in NW Ishtar Terra, Venus

    International Nuclear Information System (INIS)

    Gaddis, L.; Greeley, R.


    Venera 15/16 radar data for an area in NW Ishtar Terra, Venus, show an area with moderate radar return and a smooth textured surface which embays low lying areas of the surrounding mountainous terrain. Although this unit may be an extension of the lava plains of Lakshmi Planum to the southeast, detailed study suggests a separate volcanic center in NW Ishtar Terra. Lakshmi Planum, on the Ishtar Terra highland, exhibits major volcanic and tectonic features. On the Venera radar image radar brightness is influenced by slope and roughness; radar-facing slopes (east-facing) and rough surfaces (approx. 8 cm average relief) are bright, while west-facing slopes and smooth surfaces are dark. A series of semi-circular features, apparently topographic depressions, do not conform in orientation to major structural trends in this region of NW Ishtar Terra. The large depression in NW Ishtar Terra is similar to the calderas of Colette and Sacajawea Paterae, as all three structures are large irregular depressions. NW Ishtar Terra appears to be the site of a volcanic center with a complex caldera structure, possibly more than one eruptive vent, and associated lobed flows at lower elevations. The morphologic similarity between this volcanic center and those of Colette and Sacajawea suggests that centralized eruptions have been the dominant form of volcanism in Ishtar. The location of this volcanic center at the intersection of two major compressional mountain belts and the large size of the calders (with an inferred larg/deep magma source) support a crustal thickening/melting rather than a hot-spot origin for these magmas

  6. Sedimentology and stratigraphy of the middle Eocene Guara carbonate platform near Arguis, South-West Pyrenean foreland: Implications for basin physiography (United States)

    Huyghe, D.; Castelltort, S.; Serra-Kiel, J.; Filleaudeau, P.-Y.; Emmanuel, L.; Mouthereau, F.; Renard, M.


    The Pyrenees results from the collision between Spain and Europe and developed between the upper Cretaceous (Santonian) and the Miocene. Its foreland basins are characterised by a thick fill of detrital and carbonate sediments. The diversity of Eocene deposits in the southern Pyrenean foreland basin is of particular use in facies sedimentology due to their exceptional outcropping quality and well established stratigraphic framework and has been taken as type examples of many different sedimentary environments. Most studies have concerned facies sedimentology of detrital series in turbiditic environments, meandering and braided rivers, alluvial fans, and deltas. In contrast, the Eocene carbonate series have attracted less attention. The marine Guara limestones are a formation of lower to middle Eocene age deposited on the southern border of the western Pyrenean foreland basin (Jaca basin). They were deposited as a retrogradational carbonate platform dominated by large benthic foraminifers near or at the flexural forebulge of the foreland basin as the Pyrenean orogen developed. This formation represents the last episode of carbonate platform in the Pyrenees and remains poorly studied. In the present work our aim is to provide a detailed facies analysis and physiographic reconstructions of the Guara carbonate platform. This is crucial to unravel the respective influences of tectonics, climate and rheology of the lithosphere on the foreland basin tectonic and stratigraphic development, and it brings new constraints on the paleoenvironments and paleogeography during the Lutetian, i.e. at the beginning of the major phase of activity of the Pyrenean orogenesis. Two outcrops were studied in the Sierras Marginales at the localities of Arguis and Lusera. The Lusera section once restored in its initial position is located to the North of the Arguis section in a basinward direction such that comparing time-equivalent facies between these two sections helps us reconstructing

  7. Dynamics of Folds in the Plane (United States)

    Krylov, Nikolai A.; Rogers, Edwin L.


    Take a strip of paper and fold a crease intersecting the long edges, creating two angles. Choose one edge and consider the angle with the crease. Fold the opposite edge along the crease, creating a new crease that bisects the angle. Fold again, this time using the newly created crease and the initial edge, creating a new angle along the chosen…

  8. Petrography, Geochemistry and Petrogenesis of Volcanic Rocks, NW Ghonabad, Iran

    Directory of Open Access Journals (Sweden)

    Sedigheh Zirjanizadeh


    Full Text Available Introduction The study area is located in NW Gonabad, Razavi Khorasan Province, northern Lut block and eastern Iran north of the Lut Block. Magmatism in NW Gonabad produced plutonic and volcanic rock associations with varying geochemical compositions. These rocks are related to the Cenozoic magmatic rocks in Iran and belong to the Lut Block volcanic–plutonic belt. In this study, petrogenesis of volcanic units in northwest Gonabad was investigated. The volcanic rocks are andesites/trachyandesites, rhyolites, dacites/ rhyodacites and pyroclastics.These rocks show porphyritic, trachytic and embayed textures in phenocrysts with plagioclase, sanidine and quartz (most notably in dacite and rhyolite, hornblende and rare biotite. The most important alteration zones are propylitic, silicification and argillic.Four kaolinite- bearing clay deposits have been located in areas affectedby hydrothermal alteration of Eocene rhyolite, dacite and rhyodacite. Analytical techniques Five samples were analyzed for major elements by wavelength dispersive X-ray fluorescence (XRF and six samples were analyzed for trace elements using inductively coupled plasma-mass spectrometry (ICP-MS in the Acme Laboratories, Vancouver (Canada.Sr and Nd isotopic compositions were determined for four whole-rock samples at the Laboratório de GeologiaIsotópica da Universidade de Aveiro, Portugal. Results Petrography. The rocks in this area are consist of trachyte, andesite/ trachyandesite, dacite/ rhyodacite, principally as ignimbrites and soft tuff. The textures of phenocrysts are mainly porphyritic, glomerophyric, trachytic and embayed textures in plagioclase, hornblende and biotite. The groundmasses consist of plagioclase and fine-grainedcrystals of hornblende. Plagioclase phenocrysts and microlitesare by far the most abundant textures in andesite - trachyandesites (>25% and in size from 0.01 to 0.1mm. Euhedral to subhedral hornblende phenocrysts areabundant (3-5%and 0.1 to 0

  9. Stratigraphy and Folding in the Cenozoic Cover of a Fold-Thrust Belt in the Nallıhan Region (Ankara, Central Turkey) (United States)

    Karaaǧaç, Serdal; Koral, Hayrettin


    This study investigates stratigraphy and structural features in the Cenozoic sedimentary sequence of the fold-thrust belt of the Nallıhan-Ankara region, located to the north of the İzmir-Ankara-Erzincan Suture Zone. Permian-Triassic age marble intercalated with schist-phyllites, the upper Jurassic-lower Cretaceous age limestone and the upper Cretaceous age sandstone-shale alternation compose the basement in the study area. These rocks are unconformably overlain by the Cenozoic age terrestrial sedimentary and volcanic units. The Cenozoic stratigraphy begins with the Paleocene-Eocene age coal-bearing, at times, volcanic intercalated conglomerate-sandstone-mudstone alternation of alluvial-fluvial origins (Aksaklar Formation) and the tuff intercalated with lacustrine limestone, bituminous limestone (Kabalar Formation). These units are conformably overlain by the Eocene age basalt-andesite and pyroclastic rocks (Meyildere volcanics). The Paleocene-Eocene aged units are unconformably overlain by the conglomerate-sandstone-mudstone-marl of a lower-middle Miocene lacustrine environment (Hançili Formation). The terrestrial conglomerate-sandstone alternation (Örencik Formation) is the youngest unit in the Cenozoic stratigraphy, and is assumed to be of Pliocene age based its stratigraphic position on older units. Field study shows existence of both folds and faults in the sedimentary cover. Stereographic projections of bedding measured in the field shows N25W/45NW and N60W/4SE-oriented fold axes in the Paleocene-Eocene age units. There are also N76W/12SE and N88E/8NE-oriented folds. The difference in fold-axis orientations suggests that some folds may have been rotated in blocks bound by faults during the post-Paleocene/Eocene period. Whereas, the lower-middle Miocene units manifest N88W/13SE-oriented fold axes. It is thus proposed that the observed difference in the azimuth of fold axes represent two different folding phases, one with NE-SW and the other with N

  10. Anatomy and Histology of an Epicanthal Fold. (United States)

    Park, Jae Woo; Hwang, Kun


    The aim of this study is to elucidate the precise anatomical and histological detail of the epicanthal fold.Thirty-two hemifaces of 16 Korean adult cadavers were used in this study (30 hemifaces with an epicanthal fold, 2 without an epicanthal fold). In 2 patients who had an epicanthoplasty, the epicanthal folds were sampled.In a dissection, the periorbital skin and subcutaneous tissues were removed and the epicanthal fold was observed in relation to each part of the orbicularis oculi muscle. Specimens including the epicanthal fold were embeddedin in paraffin, sectioned at 10 um, and stained with Hematoxylin-Eosin. The horizontal section in the level of the paplebral fissure was made and the prepared slides were observed under a light microscope.In the specimens without an epicanthal fold, no connection between the upper preseptal muscle and the lower preseptal muscle was found. In the specimens with an epicanthal fold, a connection of the upper preseptal muscle to the lower preseptal muscle was observed. It was present in all 15 hemifaces (100%). There was no connection between the pretarsal muscles. In a horizontal section, the epicanthal fold was composed of 3 compartments: an outer skin lining, a core structure, and an innerskin lining. The core structure was mainly composed of muscular fibers and fibrotic tissue and they were intermingled.Surgeons should be aware of the anatomical details of an epicanthal fold. In removing or reconstructing an epicanthal fold, the fibromuscular core band should also be removed or reconstructed.

  11. Early Triassic development of a foreland basin in the Canadian high Arctic: Implications for a Pangean Rim of Fire (United States)

    Hadlari, Thomas; Dewing, Keith; Matthews, William A.; Alonso-Torres, Daniel; Midwinter, Derrick


    Following the amalgamation of Laurasia and Gondwana to form Pangea, some Triassic tectonic models show an encircling arc system called the "Pangean Rim of Fire". Here we show that the stratigraphy and Early Triassic detrital zircon provenance of the Sverdrup Basin in the Canadian Arctic is most consistent with deposition in a retro-arc foreland basin. Late Permian and Early Triassic volcanism was accompanied by relatively high rates of subsidence leading to a starved basin with volcanic input from a magmatic arc to the northwest. The mostly starved basin persisted through the Middle and Late Triassic with nearly continuous input of volcanic ash recorded as bentonites on the northwestern edge of the basin. In the latest Triassic it is interpreted that decreasing subsidence and a significant influx of sand-grade sediment when the arc was exhumed led to filling of the basin at the end of an orogenic cycle. Combined with other hints of Early Triassic arc activity along the western margin of Laurentia we propose that the Pangean Rim of Fire configuration spanned the entire Triassic. This proposed configuration represents the ring of external subduction zones that some models suggest are necessary for the breakup of supercontinents such as Pangea.

  12. Soil microbial succession along a chronosequence on a High Arctic glacier foreland, Ny-Ålesund, Svalbard: 10 years' change (United States)

    Yoshitake, Shinpei; Uchida, Masaki; Iimura, Yasuo; Ohtsuka, Toshiyuki; Nakatsubo, Takayuki


    Rapid glacial retreat in the High Arctic causes the expansion of new habitats, but the successional trajectories of soil microbial communities are not fully understood. We examined microbial succession along a chronosequence twice with a 10-year interval in a High Arctic glacier foreland. Soil samples were collected from five study sites with different ages and phospholipid fatty acids analysis was conducted to investigate the microbial biomass and community structure. Microbial biomass did not differ significantly between the two sampling times but tended to increase with the chronosequence and showed a significant correlation with soil carbon (C) and nitrogen (N) content. Microbial community structure clearly differed along the chronosequence and was correlated with C and N content. The largest shift in community structure over 10 years was observed in the newly exposed sites after deglaciation. The accumulation of soil organic matter was regarded as an important determinant both of microbial biomass and community structure over the successional period. In contrast, the initial microbial community on the newly exposed soil changed rapidly even in the High Arctic, suggesting that some key soil processes such as C and N cycling can also shift within the relatively short period after rapid glacial retreat.

  13. 2.5D seismic velocity modelling in the south-eastern Romanian Carpathians Orogen and its foreland (United States)

    Bocin, Andrei; Stephenson, Randell; Tryggvason, Ari; Panea, Ionelia; Mocanu, Victor; Hauser, Franz; Matenco, Liviu


    The DACIA-PLAN (Danube and Carpathian Integrated Action on Processes in the Lithosphere and Neotectonics) deep seismic reflection survey was performed in August-September 2001, with the objective of obtaining new information on the deep structure of the external Carpathians nappe system and the architecture of the Tertiary/Quaternary basins developed within and adjacent to the Vrancea zone, including the rapidly subsiding Focsani Basin. The DACIA-PLAN profile is about 140 km long, having a roughly WNW-ESE direction, from near the southeast Transylvanian Basin, across the mountainous south-eastern Carpathians and their foreland to near the Danube River. A high resolution 2.5D velocity model of the upper crust along the seismic profile has been determined from a tomographic inversion of the DACIA-PLAN first arrival data. The results show that the data fairly accurately resolve the transition from sediment to crystalline basement beneath the Focsani Basin, where industry seismic data are available for correlation, at depths up to about 10 km. Beneath the external Carpathians nappes, apparent basement (material with velocities above 5.8 km/s) lies at depths as shallow as 3-4 km, which is less than previously surmised on the basis of geological observations. The first arrival travel-time data suggest that there is significant lateral structural heterogeneity on the apparent basement surface in this area, suggesting that the high velocity material may be involved in Carpathian thrusting.

  14. Asymmetric hindwing foldings in rove beetles. (United States)

    Saito, Kazuya; Yamamoto, Shuhei; Maruyama, Munetoshi; Okabe, Yoji


    Foldable wings of insects are the ultimate deployable structures and have attracted the interest of aerospace engineering scientists as well as entomologists. Rove beetles are known to fold their wings in the most sophisticated ways that have right-left asymmetric patterns. However, the specific folding process and the reason for this asymmetry remain unclear. This study reveals how these asymmetric patterns emerge as a result of the folding process of rove beetles. A high-speed camera was used to reveal the details of the wing-folding movement. The results show that these characteristic asymmetrical patterns emerge as a result of simultaneous folding of overlapped wings. The revealed folding mechanisms can achieve not only highly compact wing storage but also immediate deployment. In addition, the right and left crease patterns are interchangeable, and thus each wing internalizes two crease patterns and can be folded in two different ways. This two-way folding gives freedom of choice for the folding direction to a rove beetle. The use of asymmetric patterns and the capability of two-way folding are unique features not found in artificial structures. These features have great potential to extend the design possibilities for all deployable structures, from space structures to articles of daily use.

  15. Kinetic partitioning mechanism of HDV ribozyme folding

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Jiawen; Gong, Sha; Wang, Yujie; Zhang, Wenbing, E-mail: [Department of Physics, Wuhan University, Wuhan, Hubei 430072 (China)


    RNA folding kinetics is directly tied to RNA biological functions. We introduce here a new approach for predicting the folding kinetics of RNA secondary structure with pseudoknots. This approach is based on our previous established helix-based method for predicting the folding kinetics of RNA secondary structure. In this approach, the transition rates for an elementary step: (1) formation, (2) disruption of a helix stem, and (3) helix formation with concomitant partial melting of an incompatible helix, are calculated with the free energy landscape. The folding kinetics of the Hepatitis delta virus (HDV) ribozyme and the mutated sequences are studied with this method. The folding pathways are identified by recursive searching the states with high net flux-in(out) population starting from the native state. The theory results are in good agreement with that of the experiments. The results indicate that the bi-phasic folding kinetics for the wt HDV sequence is ascribed to the kinetic partitioning mechanism: Part of the population will quickly fold to the native state along the fast pathway, while another part of the population will fold along the slow pathway, in which the population is trapped in a non-native state. Single mutation not only changes the folding rate but also the folding pathway.

  16. Vocal Fold Vibratory Changes Following Surgical Intervention. (United States)

    Chen, Wenli; Woo, Peak; Murry, Thomas


    High-speed videoendoscopy (HSV) captures direct cycle-to-cycle visualization of vocal fold movement in real time. This ultrafast recording rate is capable of visualizing the vibratory motion of the vocal folds in severely disordered phonation and provides a direct method for examining vibratory changes after vocal fold surgery. The purpose of this study was to examine the vibratory motion before and after surgical intervention. HSV was captured from two subjects with identifiable midvocal fold benign lesions and six subjects with highly aperiodic vocal fold vibration before and after phonosurgery. Digital kymography (DKG) was used to extract high-speed kymographic vocal fold images sampled at the midmembranous, anterior 1/3, and posterior 1/3 region. Spectral analysis was subsequently applied to the DKG to quantify the cycle-to-cycle movements of the left and the right vocal fold, expressed as a spectrum. Before intervention, the vibratory spectrum consisted of decreased and flat-like spectral peaks with robust power asymmetry. After intervention, increases in spectral power and decreases in power symmetry were noted. Spectral power increases were most remarkable in the midmembranous region of the vocal fold. Surgical modification resulted in improved lateral excursion of the vocal folds, vibratory function, and perceptual measures of Voice Handicap Index-10. These changes in vibratory behavior trended toward normal vocal fold vibration. Copyright © 2016 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  17. Neotectonics and structure of the Himalayan deformation front in the Kashmir Himalaya, India: Implication in defining what controls a blind thrust front in an active fold-thrust belt (United States)

    Gavillot, Y. G.; Meigs, A.; Yule, J. D.; Rittenour, T. M.; Malik, M. O. A.


    Active tectonics of a deformation front constrains the kinematic evolution and structural interaction between the fold-thrust belt and most-recently accreted foreland basin. In Kashmir, the Himalayan Frontal thrust (HFT) is blind, characterized by a broad fold, the Suruin-Mastargh anticline (SMA), and displays no emergent faults cutting either limb. A lack of knowledge of the rate of shortening and structural framework of the SMA hampers quantifying the earthquake potential for the deformation front. Our study utilized the geomorphic expression of dated deformed terraces on the Ujh River in Kashmir. Six terraces are recognized, and three yield OSL ages of 53 ka, 33 ka, and 0.4 ka. Vector fold restoration of long terrace profiles indicates a deformation pattern characterized by regional uplift across the anticlinal axis and back-limb, and by fold limb rotation on the forelimb. Differential uplift across the fold trace suggests localized deformation. Dip data and stratigraphic thicknesses suggest that a duplex structure is emplaced at depth along the basal décollement, folding the overlying roof thrust and Siwalik-Muree strata into a detachment-like fold. Localized faulting at the fold axis explains the asymmetrical fold geometry. Folding of the oldest dated terrace, suggest that rock uplift rates across the SMA range between 2.0-1.8 mm/yr. Assuming a 25° dipping ramp for the blind structure on the basis of dip data constraints, the shortening rate across the SMA ranges between 4.4-3.8 mm/yr since ~53 ka. Of that rate, ~1 mm/yr is likely absorbed by minor faulting in the near field of the fold axis. Given that Himalaya-India convergence is ~18.8-11 mm/yr, internal faults north of the deformation front, such as the Riasi thrust absorbs more of the Himalayan shortening than does the HFT in Kashmir. We attribute a non-emergent thrust at the deformation front to reflect deformation controlled by pre-existing basin architecture in Kashmir, in which the thick succession

  18. Provenance and detrital zircon geochronologic evolution of lower Brookian foreland basin deposits of the western Brooks Range, Alaska, and implications for early Brookian tectonism (United States)

    Moore, Thomas; O'Sullivan, Paul B.; Potter, Christopher J.; Donelick, Raymond A.


    The Upper Jurassic and Lower Cretaceous part of the Brookian sequence of northern Alaska consists of syntectonic deposits shed from the north-directed, early Brookian orogenic belt. We employ sandstone petrography, detrital zircon U-Pb age analysis, and zircon fission-track double-dating methods to investigate these deposits in a succession of thin regional thrust sheets in the western Brooks Range and in the adjacent Colville foreland basin to determine sediment provenance, sedimentary dispersal patterns, and to reconstruct the evolution of the Brookian orogen. The oldest and structurally highest deposits are allochthonous Upper Jurassic volcanic arc–derived sandstones that rest on accreted ophiolitic and/or subduction assemblage mafic igneous rocks. These strata contain a nearly unimodal Late Jurassic zircon population and are interpreted to be a fragment of a forearc basin that was emplaced onto the Brooks Range during arc-continent collision. Synorogenic deposits found at structurally lower levels contain decreasing amounts of ophiolite and arc debris, Jurassic zircons, and increasing amounts of continentally derived sedimentary detritus accompanied by broadly distributed late Paleozoic and Triassic (359–200 Ma), early Paleozoic (542–359 Ma), and Paleoproterozoic (2000–1750 Ma) zircon populations. The zircon populations display fission-track evidence of cooling during the Brookian event and evidence of an earlier episode of cooling in the late Paleozoic and Triassic. Surprisingly, there is little evidence for erosion of the continental basement of Arctic Alaska, its Paleozoic sedimentary cover, or its hinterland metamorphic rocks in early foreland basin strata at any structural and/or stratigraphic level in the western Brooks Range. Detritus from exhumation of these sources did not arrive in the foreland basin until the middle or late Albian in the central part of the Colville Basin.These observations indicate that two primary provenance areas provided

  19. NW Pacific mid-depth ventilation changes during the Holocene (United States)

    Rella, S.; Uchida, M.


    During the last 50 years the oxygen content of North Pacific Intermediate Water primarily originating in the Okhotsk Sea has declined suggesting decreased mid-depth water circulation, likely leading to changes in biological productivity in the NW Pacific realm and a decrease in CO2 drawdown. It is therefore of high interest to elucidate the climate-oceanic interconnections of the present interglacial period (Holocene) in the NW Pacific, in order to predict possible future climate and surface productivity changes associated with a decrease in mid-depth ventilation in this ecologically sensitive region. However, such efforts have been hampered so far by the lack of appropriate sediment cores with fast sedimentation rates during the Holocene. Core CK05-04 that was recovered in 2005 from off Shimokita peninsula, Japan, at ~1000 m depth shows sedimentation rates of ~80 cm/kyr during the Holocene and therefore presents an ideal opportunity to reconstruct for the first time the Holocene ventilation history of the NW Pacific Ocean. We employ Accelerator Mass Spectroscopy (NIES-TERRA, Tsukuba) radiocarbon analysis of co-existing benthic and planktonic foraminifera to conclude on the ventilation age of the mid-depth water using benthic-planktonic radiocarbon age differences. At the conference we would like to present the results.

  20. Adaptive Origami for Efficiently Folded Structures (United States)


    heating. Although a large fold angle at a high temperature is desirable in order to extrapolate the origami geometry toward closure, more emphasis is...AFRL-RQ-WP-TR-2016-0020 ADAPTIVE ORIGAMI FOR EFFICIENTLY FOLDED STRUCTURES James J. Joo and Greg Reich Design and Analysis Branch... ORIGAMI FOR EFFICIENTLY FOLDED STRUCTURES 5a. CONTRACT NUMBER In-house 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 61102F 6. AUTHOR(S) James J

  1. Vocal fold paralysis secondary to phonotrauma. (United States)

    Klein, Travis A L; Gaziano, Joy E; Ridley, Marion B


    A unique case of acute onset vocal fold paralysis secondary to phonotrauma is presented. The cause was forceful vocalization by a drill instructor on a firearm range. Imaging studies revealed extensive intralaryngeal and retropharyngeal hemorrhage. Laryngoscopy showed a complete left vocal fold paralysis. Relative voice rest was recommended, and the patient regained normal vocal fold mobility and function after approximately 12 weeks. Copyright © 2014 The Voice Foundation. All rights reserved.

  2. Spherical images and inextensible curved folding (United States)

    Seffen, Keith A.


    In their study, Duncan and Duncan [Proc. R. Soc. London A 383, 191 (1982), 10.1098/rspa.1982.0126] calculate the shape of an inextensible surface folded in two about a general curve. They find the analytical relationships between pairs of generators linked across the fold curve, the shape of the original path, and the fold angle variation along it. They present two special cases of generator layouts for which the fold angle is uniform or the folded curve remains planar, for simplifying practical folding in sheet-metal processes. We verify their special cases by a graphical treatment according to a method of Gauss. We replace the fold curve by a piecewise linear path, which connects vertices of intersecting pairs of hinge lines. Inspired by the d-cone analysis by Farmer and Calladine [Int. J. Mech. Sci. 47, 509 (2005), 10.1016/j.ijmecsci.2005.02.013], we construct the spherical images for developable folding of successive vertices: the operating conditions of the special cases in Duncan and Duncan are then revealed straightforwardly by the geometric relationships between the images. Our approach may be used to synthesize folding patterns for novel deployable and shape-changing surfaces without need of complex calculation.

  3. Quantification of Porcine Vocal Fold Geometry. (United States)

    Stevens, Kimberly A; Thomson, Scott L; Jetté, Marie E; Thibeault, Susan L


    The aim of this study was to quantify porcine vocal fold medial surface geometry and three-dimensional geometric distortion induced by freezing the larynx, especially in the region of the vocal folds. The medial surface geometries of five excised porcine larynges were quantified and reported. Five porcine larynges were imaged in a micro-CT scanner, frozen, and rescanned. Segmentations and three-dimensional reconstructions were used to quantify and characterize geometric features. Comparisons were made with geometry data previously obtained using canine and human vocal folds as well as geometries of selected synthetic vocal fold models. Freezing induced an overall expansion of approximately 5% in the transverse plane and comparable levels of nonuniform distortion in sagittal and coronal planes. The medial surface of the porcine vocal folds was found to compare reasonably well with other geometries, although the compared geometries exhibited a notable discrepancy with one set of published human female vocal fold geometry. Porcine vocal folds are qualitatively geometrically similar to data available for canine and human vocal folds, as well as commonly used models. Freezing of tissue in the larynx causes distortion of around 5%. The data can provide direction in estimating uncertainty due to bulk distortion of tissue caused by freezing, as well as quantitative geometric data that can be directly used in developing vocal fold models. Copyright © 2016 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  4. Guiding the folding pathway of DNA origami. (United States)

    Dunn, Katherine E; Dannenberg, Frits; Ouldridge, Thomas E; Kwiatkowska, Marta; Turberfield, Andrew J; Bath, Jonathan


    DNA origami is a robust assembly technique that folds a single-stranded DNA template into a target structure by annealing it with hundreds of short 'staple' strands. Its guiding design principle is that the target structure is the single most stable configuration. The folding transition is cooperative and, as in the case of proteins, is governed by information encoded in the polymer sequence. A typical origami folds primarily into the desired shape, but misfolded structures can kinetically trap the system and reduce the yield. Although adjusting assembly conditions or following empirical design rules can improve yield, well-folded origami often need to be separated from misfolded structures. The problem could in principle be avoided if assembly pathway and kinetics were fully understood and then rationally optimized. To this end, here we present a DNA origami system with the unusual property of being able to form a small set of distinguishable and well-folded shapes that represent discrete and approximately degenerate energy minima in a vast folding landscape, thus allowing us to probe the assembly process. The obtained high yield of well-folded origami structures confirms the existence of efficient folding pathways, while the shape distribution provides information about individual trajectories through the folding landscape. We find that, similarly to protein folding, the assembly of DNA origami is highly cooperative; that reversible bond formation is important in recovering from transient misfoldings; and that the early formation of long-range connections can very effectively enforce particular folds. We use these insights to inform the design of the system so as to steer assembly towards desired structures. Expanding the rational design process to include the assembly pathway should thus enable more reproducible synthesis, particularly when targeting more complex structures. We anticipate that this expansion will be essential if DNA origami is to continue its

  5. Approaching climate-adaptive facades with foldings

    DEFF Research Database (Denmark)

    Sack-Nielsen, Torsten


    envelopes based on folding principles such as origami. Three major aspects cover the project’s interest in this topic: Shape, kinetics and the application of new multi-functional materials form the interdisciplinary framework of this research. Shape// Initially small paper sketch models demonstrate folding...

  6. Monadic Maps and Folds for Arbitrary Datatypes

    NARCIS (Netherlands)

    Fokkinga, M.M.

    Each datatype constructor comes equiped not only with a so-called map and fold (catamorphism), as is widely known, but, under some condition, also with a kind of map and fold that are related to an arbitrary given monad. This result follows from the preservation of initiality under lifting

  7. Fold and Fit: Space Conserving Shape Editing

    KAUST Repository

    Ibrahim, Mohamed; Yan, Dong-Ming


    We present a framework that folds man-made objects in a structure-aware manner for space-conserving storage and transportation. Given a segmented 3D mesh of a man-made object, our framework jointly optimizes for joint locations, the folding order

  8. Merging monads and folds for functional programming

    NARCIS (Netherlands)

    Meijer, E.; Jeuring, J.T.


    These notes discuss the simultaneous use of generalised fold operators and monads to structure functional programs. Generalised fold operators structure programs after the decomposition of the value they consume. Monads structure programs after the computation of the value they produce. Our programs

  9. Theoretical study of the folded waveguide

    International Nuclear Information System (INIS)

    Chen, G.L.; Owens, T.L.; Whealton, J.H.


    We have applied a three-dimensional (3-D) algorithm for solving Maxwell's equations to the analysis of foleded waveguides used for fusion plasma heating at the ion cyclotron resonance frequency. A rigorous analysis of the magnetic field structure in the folded waveguide is presented. The results are compared to experimenntal measurements. Optimum conditions for the folded waveguide are discussed. 6 refs., 10 figs

  10. Experimental investigation into the mechanism of folding

    NARCIS (Netherlands)

    Kuenen, Ph.H.; Sitter, de L.U.


    The investigation of geological structures due to folding led de Sitter to form an opinion on the mechanical problems involved (Bibl. 7). His principal contention is that in simple cases the relative movements of particles with respect to eachother during deformation leading to a fold, have been

  11. A comparison of RNA folding measures

    Directory of Open Access Journals (Sweden)

    Gardner Paul P


    Full Text Available Abstract Background In the last few decades there has been a great deal of discussion concerning whether or not noncoding RNA sequences (ncRNAs fold in a more well-defined manner than random sequences. In this paper, we investigate several existing measures for how well an RNA sequence folds, and compare the behaviour of these measures over a large range of Rfam ncRNA families. Such measures can be useful in, for example, identifying novel ncRNAs, and indicating the presence of alternate RNA foldings. Results Our analysis shows that ncRNAs, but not mRNAs, in general have lower minimal free energy (MFE than random sequences with the same dinucleotide frequency. Moreover, even when the MFE is significant, many ncRNAs appear to not have a unique fold, but rather several alternative folds, at least when folded in silico. Furthermore, we find that the six investigated measures are correlated to varying degrees. Conclusion Due to the correlations between the different measures we find that it is sufficient to use only two of them in RNA folding studies, one to test if the sequence in question has lower energy than a random sequence with the same dinucleotide frequency (the Z-score and the other to see if the sequence has a unique fold (the average base-pair distance, D.

  12. Muscular anatomy of the human ventricular folds. (United States)

    Moon, Jerald; Alipour, Fariborz


    Our purpose in this study was to better understand the muscular anatomy of the ventricular folds in order to help improve biomechanical modeling of phonation and to better understand the role of these muscles during phonatory and nonphonatory tasks. Four human larynges were decalcified, sectioned coronally from posterior to anterior by a CryoJane tape transfer system, and stained with Masson's trichrome. The total and relative areas of muscles observed in each section were calculated and used for characterizing the muscle distribution within the ventricular folds. The ventricular folds contained anteriorly coursing thyroarytenoid and ventricularis muscle fibers that were in the lower half of the ventricular fold posteriorly, and some ventricularis muscle was evident in the upper and lateral portions of the fold more anteriorly. Very little muscle tissue was observed in the medial half of the fold, and the anterior half of the ventricular fold was largely devoid of any muscle tissue. All 4 larynges contained muscle bundles that coursed superiorly and medially through the upper half of the fold, toward the lateral margin of the epiglottis. Although variability of expression was evident, a well-defined thyroarytenoid muscle was readily apparent lateral to the arytenoid cartilage in all specimens.

  13. Graph-representation of oxidative folding pathways

    Directory of Open Access Journals (Sweden)

    Kaján László


    Full Text Available Abstract Background The process of oxidative folding combines the formation of native disulfide bond with conformational folding resulting in the native three-dimensional fold. Oxidative folding pathways can be described in terms of disulfide intermediate species (DIS which can also be isolated and characterized. Each DIS corresponds to a family of folding states (conformations that the given DIS can adopt in three dimensions. Results The oxidative folding space can be represented as a network of DIS states interconnected by disulfide interchange reactions that can either create/abolish or rearrange disulfide bridges. We propose a simple 3D representation wherein the states having the same number of disulfide bridges are placed on separate planes. In this representation, the shuffling transitions are within the planes, and the redox edges connect adjacent planes. In a number of experimentally studied cases (bovine pancreatic trypsin inhibitor, insulin-like growth factor and epidermal growth factor, the observed intermediates appear as part of contiguous oxidative folding pathways. Conclusions Such networks can be used to visualize folding pathways in terms of the experimentally observed intermediates. A simple visualization template written for the Tulip package can be obtained from V.A.

  14. Geometric U-folds in four dimensions (United States)

    Lazaroiu, C. I.; Shahbazi, C. S.


    We describe a general construction of geometric U-folds compatible with a non-trivial extension of the global formulation of four-dimensional extended supergravity on a differentiable spin manifold. The topology of geometric U-folds depends on certain flat fiber bundles which encode how supergravity fields are globally glued together. We show that smooth non-trivial U-folds of this type can exist only in theories where both the scalar and space-time manifolds have non-trivial fundamental group and in addition the scalar map of the solution is homotopically non-trivial. Consistency with string theory requires smooth geometric U-folds to be glued using subgroups of the effective discrete U-duality group, implying that the fundamental group of the scalar manifold of such solutions must be a subgroup of the latter. We construct simple examples of geometric U-folds in a generalization of the axion-dilaton model of \

  15. Fold and Fit: Space Conserving Shape Editing

    KAUST Repository

    Ibrahim, Mohamed


    We present a framework that folds man-made objects in a structure-aware manner for space-conserving storage and transportation. Given a segmented 3D mesh of a man-made object, our framework jointly optimizes for joint locations, the folding order, and folding angles for each part of the model, enabling it to transform into a spatially efficient configuration while keeping its original functionality as intact as possible. That is, if a model is supposed to withstand several forces in its initial state to serve its functionality, our framework places the joints between the parts of the model such that the model can withstand forces with magnitudes that are comparable to the magnitudes applied on the unedited model. Furthermore, if the folded shape is not compact, our framework proposes further segmentation of the model to improve its compactness in its folded state.

  16. [Clinical analysis of vocal fold firbrous mass]. (United States)

    Chen, Hao; Sun, Jing Wu; Wan, Guang Lun; Hu, Yan Ming


    To explore the character of laryngoscopy finding, voice, and therapy of vocal fold fibrous mass. Clinical data, morphology, voice character, surgery and pathology of 15 cases with vocal fold fibrous mass were analyzed. The morbidity of vocal fold fibrous mass might be related to overuse of voice and laryngopharyngeal reflex. Laryngoscopy revealed shuttle line appearance, smoothness and decreased mucosal wave of vocal fold. These patients were invalid for voice training and might be improved by surgery, but recovery is slow. The morbidity of vocal fold fibrous mass might be related to overuse of voice and laryngopharyngeal reflex. Conservative treatment is ineffective for this disease, and surgery might improve. Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

  17. Sarcoidosis Presenting as Bilateral Vocal Fold Immobility. (United States)

    Hintze, Justin M; Gnagi, Sharon H; Lott, David G


    Bilateral true vocal fold paralysis is rarely attributable to inflammatory diseases. Sarcoidosis is a rare but important etiology of bilateral true vocal fold paralysis by compressive lymphadenopathy, granulomatous infiltration, and neural involvement. We describe the first reported case of sarcoidosis presenting as bilateral vocal fold immobility caused by direct fixation by granulomatous infiltration severe enough to necessitate tracheostomy insertion. In addition, we discuss the presentation, the pathophysiology, and the treatment of this disease with a review of the literature of previously reported cases of sarcoidosis-related vocal fold immobility. Sarcoidosis should therefore be an important consideration for the otolaryngologist's differential diagnosis of true vocal fold immobility. Copyright © 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  18. Microvascular lesions of the true vocal fold. (United States)

    Postma, G N; Courey, M S; Ossoff, R H


    Microvascular lesions, also called varices or capillary ectasias, in contrast to vocal fold polyps with telangiectatic vessels, are relatively small lesions arising from the microcirculation of the vocal fold. Varices are most commonly seen in female professional vocalists and may be secondary to repetitive trauma, hormonal variations, or repeated inflammation. Microvascular lesions may either be asymptomatic or cause frank dysphonia by interrupting the normal vibratory pattern, mass, or closure of the vocal folds. They may also lead to vocal fold hemorrhage, scarring, or polyp formation. Laryngovideostroboscopy is the key in determining the functional significance of vocal fold varices. Management of patients with a varix includes medical therapy, speech therapy, and occasionally surgical vaporization. Indications for surgery are recurrent hemorrhage, enlargement of the varix, development of a mass in conjunction with the varix or hemorrhage, and unacceptable dysphonia after maximal medical and speech therapy due to a functionally significant varix.

  19. A three-dimensional model of the Pyrenees and their foreland basins from geological and gravimetric data (United States)

    Wehr, H.; Chevrot, S.; Courrioux, G.; Guillen, A.


    We construct a three-dimensional geological model of the Pyrenees and their foreland basins with the Geomodeller. This model, which accounts for different sources of geological and geophysical informations, covers the whole Pyrenees, from the Atlantic Ocean to the Mediterranean Sea, and from the Iberian range to the Massif Central, down to 70 km depth. We model the geological structure with a stratigraphic column composed of a superposition of layers representing the mantle, lower, middle, and upper crusts. The sedimentary basins are described by two layers which allow us to make the distinction between Mesozoic and Cenozoic sediments, which are characterized by markedly different densities and seismic velocities. Since the Pyrenees result from the convergence between the Iberian and European plates, we ascribe to each plate its own stratigraphic column in order to be able to model the imbrication of Iberian and European crusts along this fossile plate boundary. We also introduce two additional units which describe the orogenic prism and the water column in the Bay of Biscay and in the Mediterranean Sea. The last ingredient is a unit that represents bodies of shallow exhumed and partly serpentinized lithospheric mantle, which are assumed to produce the positive Bouguer gravity anomalies in the North Pyrenean Zone. A first 3D model is built using only the geological information coming from geological maps, drill-holes, and seismic sections. We use the potential field method implemented in Geomodeller to interpolate these geological data. This model is then refined in order to better explain the observed Bouguer anomalies by adding new constraints on the main crustal interfaces. The final model explains the observed Bouguer anomalies with a standard deviation less than 3.4 mGal, and reveals anomalous deep structures beneath the eastern Pyrenees.

  20. Mobility and eco-risk of trace metals in soils at the Hailuogou Glacier foreland in eastern Tibetan Plateau. (United States)

    Bing, Haijian; Wu, Yanhong; Zhou, Jun; Liang, Jianhong; Wang, Jipeng; Yang, Zijiang


    The concentrations and fractions of cadmium (Cd), copper (Cu), lead (Pb), and zinc (Zn) in soils collected from Hailuogou Glacier foreland in eastern Tibetan Plateau were analyzed to decipher their mobility, and their eco-risk was assessed combined with multiple environmental indices. The concentrations of Cd were more than ten times higher than its local background in the O horizon and nearly three times higher in the A horizon. The concentrations of Pb and Zn were relatively high in the O horizon, whereas that of Cu increased with soil depth. The main fractions of metals in the surface horizons were reducible and acid-soluble for Cd, oxidizable and residual for Cu, reducible and oxidizable for Pb, and reducible and residual for Zn. The metal mobility generally followed the order of Cd > Pb > Zn > Cu in the O horizon and Cd > Pb > Cu > Zn in the A horizon. Sorption and complexation by soil organic matters imparted an important effect on the mobilization and transformation of Cd, Pb, and Zn in the soils. The oxidizable Cu fraction in the soils showed significant correlation with organic matters, and soil pH mainly modulated the acid-soluble and reducible Cu fractions. The concentrations and other environmental indices including contamination factor, enrichment factor, geoaccumulation index, and risk assessment index revealed that Cd reached high contamination and very high eco-risk, Pb had medium contamination but low eco-risk, Zn showed low contamination and low eco-risk, and Cu was not contaminated in the soils. The data indicated that Cd was the priority to concern in the soils of Hailuogou Glacier catchment.

  1. The Eocene-Oligocene transition in the North Alpine Foreland Basin and subsequent closure of a Paratethys gateway (United States)

    van der Boon, A.; Beniest, A.; Ciurej, A.; Gaździcka, E.; Grothe, A.; Sachsenhofer, R. F.; Langereis, C. G.; Krijgsman, W.


    During the Eocene-Oligocene transition (EOT), a major palaeoenvironmental change took place in the Paratethys Sea of central Eurasia. Restricted connectivity and increased stratification resulted in wide-spread deposition of organic-rich sediments which nowadays make up important hydrocarbon source rocks. The North Alpine Foreland Basin (NAFB) was a major gateway of the Paratethys Sea to the open ocean during the Eocene, but the age of closure of this gateway is still uncertain. The Ammer section in southern Germany documents the shallowing of this connection and subsequent disappearance of marine environments in the NAFB, as reflected in its sedimentary succession of turbidites to marls (Deutenhausen to Tonmergel beds), via coastal sediments (Baustein beds) to continental conglomerates (Weißach beds). Here, we apply organic geochemistry and date the lithological transitions in the Ammer section using integrated stratigraphy, including magnetostratigraphy and biostratigraphy. Nannoplankton and dinocyst results can be reconciled when dinoflagellate species Wetzeliella symmetrica is of late Eocene age. Our magnetostratigraphy then records C13r-C13n-C12r and allows calculation of sediment accumulation rates and estimation of ages of lithological transitions. We show that the shallowing from turbiditic slope deposits (Deutenhausen beds) to shelf sediments (Tonmergel beds) coincides with the Eocene-Oligocene boundary at 33.9 Ma. The transition to continental sediments is dated at ca. 33.15 Ma, significantly older than suggested by previous studies. We conclude that the transition from marine to continental sediments drastically reduced the marine connection through the western part of the NAFB and influenced the oxygen conditions of the Paratethys Sea.

  2. Magnetotelluric Imaging of the Lithosphere Across the Variscan Orogen (Iberian Autochthonous Domain, NW Iberia) (United States)

    Alves Ribeiro, J.; Monteiro-Santos, F. A.; Pereira, M. F.; Díez Fernández, R.; Dias da Silva, Í.; Nascimento, C.; Silva, J. B.


    A new magnetotelluric (MT) survey comprising 17 MT soundings throughout a 30 km long N30°W transect in the Iberian autochthons domain of NW Iberia (Central Iberian Zone) is presented. The 2-D inversion model shows the resistivity structure of the continental crust up to 10 km depth, heretofore unavailable for this region of the Variscan Orogen. The MT model reveals a wavy structure separating a conductive upper layer underlain by a resistive layer, thus picturing the two main tectonic blocks of a large-scale D2 extensional shear zone (i.e., Pinhel shear zone). The upper layer represents a lower grade metamorphic domain that includes graphite-rich rocks. The lower layer consists of high-grade metamorphic rocks that experienced partial melting and are associated with granites (more resistive) emplaced during crustal thinning. The wavy structure is the result of superimposed crustal shortening responsible for the development of large-scale D3 folds (e.g., Marofa synform), later deflected and refolded by a D4 strike-slip shear zone (i.e., Juzbado-Penalva do Castelo shear zone). The later contribution to the final structure of the crust is marked by the intrusion of postkinematic granitic rocks and the propagation of steeply dipping brittle fault zones. Our study demonstrates that MT imaging is a powerful tool to understand complex crustal structures of ancient orogens in order to design future prospecting surveys for mineral deposits of economic interest.

  3. Successive reactivation of older structures under variable heat flow conditions evidenced by K-Ar fault gouge dating in Sierra de Ambato, northern Argentine broken foreland (United States)

    Nóbile, Julieta C.; Collo, Gilda; Dávila, Federico M.; Martina, Federico; Wemmer, Klaus


    The Argentine broken foreland has been the subject of continuous research to determine the uplift and exhumation history of the region. High-elevation mountains are the result of N-S reverse faults that disrupted a W-E Miocene Andean foreland basin. In the Sierra de Ambato (northern Argentine broken foreland) the reverse faults offset Neogene sedimentary rocks (Aconquija Fm., ˜9 Ma) and affect the basement comprising Paleozoic metamorphic rocks that have been dated at ˜477-470 Ma. In order to establish a chronology of these faults affecting the previous continuous basin we date the formation age of clay minerals associated with fault gouge using the K-Ar dating technique. Clay mineral formation is a fundamental process in the evolution of faults under the brittle regime (history with a minimum age of ˜360 Ma and a last clay minerals forming event at ˜220 Ma. Moreover, given the progression of apparent ages decreasing from coarse to fine size fractions (˜360-311 Ma for 2-1 μm grain size fraction, ˜326-286 Ma for 1-0.2 μm and ˜291-219 Ma of <0.2 μm), we modeled discrete deformation events at ˜417 Ma (ending of the Famatinian cycle), ˜317-326 Ma (end of Gondwanic orogeny), and ˜194-279 Ma (Early Permian - Jurassic deformation). According to our data, the Neogene reactivation would not have affected the K-Ar system neither generated a significant clay minerals crystallization in the fault gouge, although an exhumation of more than 2 Km is recorded in this period from stratigraphic data.

  4. Mio Pliocene volcaniclastic deposits in the Famatina Ranges, southern Central Andes: A case of volcanic controls on sedimentation in broken foreland basins (United States)

    Martina, Federico; Dávila, Federico M.; Astini, Ricardo A.


    A well-constrained record of Miocene-Pliocene explosive volcanism is preserved within the broken foreland of Western Argentina along the Famatina Ranges. This paper focuses on the volcaniclastic record known as the Río Blanco member of the El Durazno Formation. Three facies can be recognized in the study area: (1) massive tuffs; (2) volcaniclastic conglomerates and (3) pumiceous sandstones. These facies are interpreted as primary pyroclastic flow deposits (ignimbrites) and reworked volcanogenic deposits within interacting volcanic-fluvial depositional systems. Alternation between ignimbrites and volcanogenic sandstones and conglomerates suggest a recurrent pattern of sedimentation related to recurrent volcanic activity. Considering the facies mosaic and relative thicknesses of facies, short periods of syn-eruption sedimentation (volcaniclastic deposits) seem to have been separated by longer inter-eruption periods, where normal stream-flow processes were dominant. The volcaniclastic component decreases up-section, suggesting a gradual reduction in volcanic activity. The mean sedimentation rate of the Río Blanco member is higher (0.44 mm/year) than those obtained for the underlying and overlying units. This increase cannot be fully explained by foreland basement deformation and tectonic loading. Hence, we propose subsidence associated with volcanic activity as the causal mechanism. Volcanism would have triggered additional accommodation space through coeval pyroclastic deposition, modification of the stream equilibrium profile, flexural loading of volcanoes, and thermal processes. These mechanisms may have favored the preservation of volcaniclastic beds in the high-gradient foreland system of Famatina during the Mio-Pliocene. Thus, the Río Blanco member records the response of fluvial systems to large, volcanism-induced sediment loads.

  5. Provenancing fish in freshwaters of the Alpine Foreland using Sr/Ca and 87Sr/86Sr ratios in otoliths and otolith shape parameters

    Directory of Open Access Journals (Sweden)

    Johannes Oehm


    Although the studied freshwaters were located only in a 50 km range around lake Chiemsee on a similar geological background, differences in water chemistry, fish otolith chemistry and shape were identified. Species specific differences in reflection of the Sr/Ca ratio of a specific water body were detected. Microchemical and morphological otoliths analyses complemented each other and allowed assigning fish to specific groups of waters of origin. This information provides an important basis for the further application of otolith chemistry and shape analysis in the Alpine foreland for a diverse range of ecological questions.

  6. Coarsely resolved topography along protein folding pathways (United States)

    Fernández, Ariel; Kostov, Konstantin S.; Berry, R. Stephen


    The kinetic data from the coarse representation of polypeptide torsional dynamics described in the preceding paper [Fernandez and Berry, J. Chem. Phys. 112, 5212 (2000), preceding paper] is inverted by using detailed balance to obtain a topographic description of the potential-energy surface (PES) along the dominant folding pathway of the bovine pancreatic trypsin inhibitor (BPTI). The topography is represented as a sequence of minima and effective saddle points. The dominant folding pathway displays an overall monotonic decrease in energy with a large number of staircaselike steps, a clear signature of a good structure-seeker. The diversity and availability of alternative folding pathways is analyzed in terms of the Shannon entropy σ(t) associated with the time-dependent probability distribution over the kinetic ensemble of contact patterns. Several stages in the folding process are evident. Initially misfolded states form and dismantle revealing no definite pattern in the topography and exhibiting high Shannon entropy. Passage down a sequence of staircase steps then leads to the formation of a nativelike intermediate, for which σ(t) is much lower and fairly constant. Finally, the structure of the intermediate is refined to produce the native state of BPTI. We also examine how different levels of tolerance to mismatches of side chain contacts influence the folding kinetics, the topography of the dominant folding pathway, and the Shannon entropy. This analysis yields upper and lower bounds of the frustration tolerance required for the expeditious and robust folding of BPTI.

  7. Melody discrimination and protein fold classification

    Directory of Open Access Journals (Sweden)

    Robert P. Bywater


    Full Text Available One of the greatest challenges in theoretical biophysics and bioinformatics is the identification of protein folds from sequence data. This can be regarded as a pattern recognition problem. In this paper we report the use of a melody generation software where the inputs are derived from calculations of evolutionary information, secondary structure, flexibility, hydropathy and solvent accessibility from multiple sequence alignment data. The melodies so generated are derived from the sequence, and by inference, of the fold, in ways that give each fold a sound representation that may facilitate analysis, recognition, or comparison with other sequences.

  8. A bidirectional shape memory alloy folding actuator

    International Nuclear Information System (INIS)

    Paik, Jamie K; Wood, Robert J


    This paper presents a low-profile bidirectional folding actuator based on annealed shape memory alloy sheets applicable for meso- and microscale systems. Despite the advantages of shape memory alloys—high strain, silent operation, and mechanical simplicity—their application is often limited to unidirectional operation. We present a bidirectional folding actuator that produces two opposing 180° motions. A laser-patterned nickel alloy (Inconel 600) heater localizes actuation to the folding sections. The actuator has a thin ( < 1 mm) profile, making it appropriate for use in robotic origami. Various design parameters and fabrication variants are described and experimentally explored in the actuator prototype. (paper)

  9. Folded Plate Structures as Building Envelopes

    DEFF Research Database (Denmark)

    Falk, Andreas; Buelow, Peter von; Kirkegaard, Poul Henning


    This paper treats applications of cross-laminated timber (CLT) in structural systems for folded façade solutions. Previous work on CLT-based systems for folded roofs has shown a widening range of structural possibilities to develop timber-based shells. Geometric and material properties play...... CLT-based systems, which are studied and analysed by using a combination of digital tools for structural and environmental design and analysis. The results show gainful, rational properties of folded systems and beneficial effects from an integration of architectural and environmental performance...... criteria in the design of CLT-based façades....

  10. Mechanical Models of Fault-Related Folding

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, A. M.


    The subject of the proposed research is fault-related folding and ground deformation. The results are relevant to oil-producing structures throughout the world, to understanding of damage that has been observed along and near earthquake ruptures, and to earthquake-producing structures in California and other tectonically-active areas. The objectives of the proposed research were to provide both a unified, mechanical infrastructure for studies of fault-related foldings and to present the results in computer programs that have graphical users interfaces (GUIs) so that structural geologists and geophysicists can model a wide variety of fault-related folds (FaRFs).

  11. Topology Explains Why Automobile Sunshades Fold Oddly (United States)

    Feist, Curtis; Naimi, Ramin


    Automobile sunshades always fold into an "odd" number of loops. The explanation why involves elementary topology (braid theory and linking number, both explained in detail here with definitions and examples), and an elementary fact from algebra about symmetric group.

  12. Reinke Edema: Watch For Vocal Fold Cysts. (United States)

    Tüzüner, Arzu; Demirci, Sule; Yavanoglu, Ahmet; Kurkcuoglu, Melih; Arslan, Necmi


    Reinke edema is one of the common cause of dysphonia middle-aged population, and severe thickening of vocal folds require surgical treatment. Smoking plays a major role on etiology. Vocal fold cysts are also benign lesions and vocal trauma blamed for acquired cysts. We would like to present 3 cases with vocal fold cyst related with Reinke edema. First case had a subepidermal epidermoid cyst with Reinke edema, which could be easily observed before surgery during laryngostroboscopy. Second case had a mucous retention cyst into the edematous Reinke tissue, which was detected during surgical intervention, and third case had a epidermoid cyst that occurred 2 months after before microlaryngeal operation regarding Reinke edema reduction. These 3 cases revealed that surgical management of Reinke edema needs a careful dissection and close follow-up after surgery for presence of vocal fold cysts.

  13. Origami: Paper Folding--The Algorithmic Way. (United States)

    Heukerott, Pamela Beth


    Describes origami, the oriental art of paper folding as an activity to teach upper elementary students concepts and skills in geometry involving polygons, angles, measurement, symmetry, and congruence. (PK)

  14. Frustration in Condensed Matter and Protein Folding (United States)

    Li, Z.; Tanner, S.; Conroy, B.; Owens, F.; Tran, M. M.; Boekema, C.


    By means of computer modeling, we are studying frustration in condensed matter and protein folding, including the influence of temperature and Thomson-figure formation. Frustration is due to competing interactions in a disordered state. The key issue is how the particles interact to reach the lowest frustration. The relaxation for frustration is mostly a power function (randomly assigned pattern) or an exponential function (regular patterns like Thomson figures). For the atomic Thomson model, frustration is predicted to decrease with the formation of Thomson figures at zero kelvin. We attempt to apply our frustration modeling to protein folding and dynamics. We investigate the homogeneous protein frustration that would cause the speed of the protein folding to increase. Increase of protein frustration (where frustration and hydrophobicity interplay with protein folding) may lead to a protein mutation. Research is supported by WiSE@SJSU and AFC San Jose.

  15. Self-folding miniature elastic electric devices

    International Nuclear Information System (INIS)

    Miyashita, Shuhei; Meeker, Laura; Rus, Daniela; Tolley, Michael T; Wood, Robert J


    Printing functional materials represents a considerable impact on the access to manufacturing technology. In this paper we present a methodology and validation of print-and-self-fold miniature electric devices. Polyvinyl chloride laminated sheets based on metalized polyester film show reliable self-folding processes under a heat application, and it configures 3D electric devices. We exemplify this technique by fabricating fundamental electric devices, namely a resistor, capacitor, and inductor. Namely, we show the development of a self-folded stretchable resistor, variable resistor, capacitive strain sensor, and an actuation mechanism consisting of a folded contractible solenoid coil. Because of their pre-defined kinematic design, these devices feature elasticity, making them suitable as sensors and actuators in flexible circuits. Finally, an RLC circuit obtained from the integration of developed devices is demonstrated, in which the coil based actuator is controlled by reading a capacitive strain sensor. (paper)

  16. Seismic velocity structure of the crust in NW Namibia: Impact of rifting and mantle plume activity (United States)

    Bauer, K.; Heit, B.; Muksin, U.; Yuan, X.


    The continental crust in northwestern Namibiamainly was formed during to the Neoproterozoic assembly of Gondwana. The collision of old African and South American cratonic coressuch as the Congo, Kalahari and Rio de la Plata cratons led tothe development of the Pan-African Damara orogen. The fold systemconsists of an intracratonic branch in northern central Namibia (named Damara Belt), and two coast-parallel branches, the Kaoko Belt in northern Namibia and the Gariep Belt in the border region between Namibia and theRepublic of South Africa. During the Early Cretaceous opening of the South Atlantic ocean, the crust in NW Namibia was prominently affected by the Tristan da Cunha mantle plume, as evidenced by the emplacement of the Etendeka continental flood basalts.A local earthquake tomography was carried out in NW Namibia to investigateif and to what degree the deeper continental crust was modified by the magmaticactivity during rifting and the impingement of the Tristan da Cunhamantle plume. We analyzed data from 28 onshore stations of the temporaryWALPASS seismic network. Stations were covering the continental marginaround the landfall of the Walvis Ridge, parts of the Kaoko Belt and Damara Belt,and marginally the southwestern edges of the Congo craton.First arrivals of P and S waves were identified and travel times werepicked manually. 1D inversion was carried out with VELEST to derivestarting models and the initial seismicity distribution, and SIMUL2000was used for the subsequent 3D tomographic inversion. The resultingseismicity distribution mainly follows the structures of the Pan-Africanorogenic belts. The majority of events was localized in the upper crust,but additional seismicity was also found in the deeper crust.An anomaly of increased P velocities is revealed in the deep crust under the Etendekaflood basalt province. Increased P velocities can be explained by mafic and ultra-maficmaterial which intruded in the lower crust. The anomaly appears to be rather

  17. Benign Lesions of The Vocal Fold

    Directory of Open Access Journals (Sweden)

    Ozgur Surmelioglu


    Full Text Available Benign lesions of vocal folds are common disorders. Fifty percent of patients who have sound complaints are found to have these lesions after endoscopic and stroboscopic examinations. Benign vocal fold diseases are primarily caused by vibratory trauma. However they may also occur as a result of viral infections and congenital causes. These lesions are often presented with the complaints of dysphonia. [Archives Medical Review Journal 2013; 22(1.000: 86-95

  18. Folding of non-Euclidean curved shells (United States)

    Bende, Nakul; Evans, Arthur; Innes-Gold, Sarah; Marin, Luis; Cohen, Itai; Santangelo, Christian; Hayward, Ryan


    Origami-based folding of 2D sheets has been of recent interest for a variety of applications ranging from deployable structures to self-folding robots. Though folding of planar sheets follows well-established principles, folding of curved shells involves an added level of complexity due to the inherent influence of curvature on mechanics. In this study, we use principles from differential geometry and thin shell mechanics to establish fundamental rules that govern folding of prototypical creased shells. In particular, we show how the normal curvature of a crease line controls whether the deformation is smooth or discontinuous, and investigate the influence of shell thickness and boundary conditions. We show that snap-folding of shells provides a route to rapid actuation on time-scales dictated by the speed of sound. The simple geometric design principles developed can be applied at any length-scale, offering potential for bio-inspired soft actuators for tunable optics, microfluidics, and robotics. This work was funded by the National Science Foundation through EFRI ODISSEI-1240441 with additional support to S.I.-G. through the UMass MRSEC DMR-0820506 REU program.

  19. Vocal fold hemorrhage: factors predicting recurrence. (United States)

    Lennon, Christen J; Murry, Thomas; Sulica, Lucian


    Vocal fold hemorrhage is an acute phonotraumatic injury treated with voice rest; recurrence is a generally accepted indication for surgical intervention. This study aims to identify factors predictive of recurrence based on outcomes of a large clinical series. Retrospective cohort. Retrospective review of cases of vocal fold hemorrhage presenting to a university laryngology service. Demographic information was compiled. Videostroboscopic exams were evaluated for hemorrhage extent, presence of varix, mucosal lesion, and/or vocal fold paresis. Vocal fold hemorrhage recurrence was the main outcome measure. Follow-up telephone survey was used to complement clinical data. Forty-seven instances of vocal fold hemorrhage were evaluated (25M:22F; 32 professional voice users). Twelve of the 47 (26%) patients experienced recurrence. Only the presence of varix demonstrated significant association with recurrence (P = 0.0089) on multivariate logistic regression. Vocal fold hemorrhage recurred in approximately 26% of patients. Varix was a predictor of recurrence, with 48% of those with varix experiencing recurrence. Monitoring, behavioral management and/or surgical intervention may be indicated to treat patients with such characteristics. © 2013 The American Laryngological, Rhinological and Otological Society, Inc.

  20. 3D Architecture and evolution of the Po Plain-Northern Adriatic Foreland basin during Plio-Pleistocene time (United States)

    Amadori, Chiara; Toscani, Giovanni; Ghielmi, Manlio; Maesano, Francesco Emanuele; D'Ambrogi, Chiara; Lombardi, Stefano; Milanesi, Riccardo; Panara, Yuri; Di Giulio, Andrea


    The Pliocene-Pleistocene tectonic and sedimentary evolution of the eastern Po Plain and northern Adriatic Foreland Basin (PPAF) (extended ca. 35,000 km2) was the consequence of severe Northern Apennine compressional activity and climate-driven eustatic changes. According with the 2D seismic interpretation, facies analysis and sequence stratigraphy approach by Ghielmi et al. (2013 and references therein), these tectono-eustatic phases generated six basin-scale unconformities referred as Base Pliocene (PL1), Intra-Zanclean (PL2), Intra-Piacenzian (PL3), Gelasian (PL4), Base Calabrian (PS1) and Late Calabrian (PS2). We present a basin-wide detailed 3D model of the PPAF region, derived from the interpretation of these unconformities in a dense network of seismic lines (ca. 6,000 km) correlated with more than 200 well stratigraphies (courtesy of ENI E&P). The initial 3D time-model has been time-to-depth converted using the 3D velocity model created with Vel-IO 3D, a tool for 3D depth conversions and then validated and integrated with depth domain dataset from bibliography and well log. Resultant isobath and isopach maps are produced to inspect step-by-step the basin paleogeographic evolution; it occurred through alternating stages of simple and fragmented foredeeps. Changes in the basin geometry through time, from the inner sector located in the Emilia-Romagna Apennines to the outermost region (Veneto and northern Adriatic Sea), were marked by repeated phases of outward migration of two large deep depocenters located in front of Emilia arcs on the west, and in front of Ferrara-Romagna thrusts on the east. During late Pliocene-early Pleistocene, the inner side of the Emilia-Romagna arcs evolved into an elongated deep thrust-top basin due to a strong foredeep fragmentation then, an overall tectono-stratigraphic analysis shows also a decreasing trend of tectonic intensity of the Northern Apennine since Pleistocene until present.

  1. Stress field sensitivity analysis within Mesozoic successions in the Swiss Alpine foreland using 3-D-geomechanical-numerical models (United States)

    Reiter, Karsten; Hergert, Tobias; Heidbach, Oliver


    The in situ stress conditions are of key importance for the evaluation of radioactive waste repositories. In stage two of the Swiss site selection program, the three siting areas of high-level radioactive waste are located in the Alpine foreland in northern Switzerland. The sedimentary succession overlays the basement, consisting of variscan crystalline rocks as well as partly preserved Permo-Carboniferous deposits in graben structures. The Mesozoic sequence represents nearly the complete era and is covered by Cenozoic Molasse deposits as well as Quaternary sediments, mainly in the valleys. The target horizon (designated host rock) is an >100 m thick argillaceous Jurassic deposit (Opalinus Clay). To enlighten the impact of site-specific features on the state of stress within the sedimentary succession, 3-D-geomechanical-numerical models with elasto-plastic rock properties are set up for three potential siting areas. The lateral extent of the models ranges between 12 and 20 km, the vertical extent is up to a depth of 2.5 or 5 km below sea level. The sedimentary sequence plus the basement are separated into 10 to 14 rock mechanical units. The Mesozoic succession is intersected by regional fault zones; two or three of them are present in each model. The numerical problem is solved with the finite element method with a resolution of 100-150 m laterally and 10-30 m vertically. An initial stress state is established for all models taking into account the depth-dependent overconsolidation ratio in Opalinus Clay in northern Switzerland. The influence of topography, rock properties, friction on the faults as well as the impact of tectonic shortening on the state of stress is investigated. The tectonic stress is implemented with lateral displacement boundary conditions, calibrated on stress data that are compiled in Northern Switzerland. The model results indicate that the stress perturbation by the topography is significant to depths greater than the relief contrast. The

  2. The radioisotopically constrained Viséan onset of turbidites in the Moravian-Silesian part of the Rhenohercynian foreland basin (Central European Variscides) (United States)

    Jirásek, Jakub; Otava, Jiří; Matýsek, Dalibor; Sivek, Martin; Schmitz, Mark D.


    The Březina Formation represents the initiation of siliciclastic flysch turbidite sedimentation at the eastern margin of Bohemian Massif or within the Rhenohercynian foreland basin. Its deposition started after drowning of the Devonian carbonate platform during Viséan (Mississippian) times, resulting in a significant interval of black siliceous shale and variegated fossiliferous shale deposition in a starved basin. Near the top of the Březina Formation an acidic volcanoclastic layer (tuff) of rhyolitic composition has been dated with high precision U-Pb zircon chemical abrasion isotope dilution method at 337.73 ± 0.16 Ma. This new radiometric age correlates with the previously inferred stratigraphic age of the locality and the current calibration of the Early Carboniferous geologic time scale. Shales of the Březina Formation pass gradually upwards into the siliciclastics of the Rozstání Formation of the Drahany culm facies. Thus our new age offers one of the few available radioisotopic constraints on the time of onset of siliciclastic flysch turbidites in the Rhenohercynian foreland basin of the European Variscides.

  3. Experimental investigation of protein folding and misfolding. (United States)

    Dobson, Christopher M


    Newly synthesised proteins need to fold, often to intricate and close-packed structures, in order to function. The underlying mechanism by which this complex process takes place both in vitro and in vivo is now becoming understood, at least in general terms, as a result of the application of a wide range of biophysical and computational methods used in combination with the techniques of biochemistry and protein engineering. It is increasingly apparent, however, that folding is not only crucial for generating biological activity, but that it is also coupled to a wide range of processes within the cell, ranging from the trafficking of proteins to specific organelles to the regulation of cell growth and differentiation. Not surprisingly, therefore, the failure of proteins to fold appropriately, or to remain correctly folded, is associated with a large number of cellular malfunctions that give rise to disease. Misfolding, and its consequences such as aggregation, can be investigated by extending the types of techniques used to study the normal folding process. Application of these techniques is enabling the development of a unified description of the interconversion and regulation of the different conformational states available to proteins in living systems. Such a description proves a generic basis for understanding the fundamental links between protein misfolding and its associated clinical disorders, such as Alzheimer's disease and Type II diabetes, and for exploring novel therapeutic strategies directed at their prevention and treatment on a rational basis.

  4. Kinetics and Thermodynamics of Membrane Protein Folding

    Directory of Open Access Journals (Sweden)

    Ernesto A. Roman


    Full Text Available Understanding protein folding has been one of the great challenges in biochemistry and molecular biophysics. Over the past 50 years, many thermodynamic and kinetic studies have been performed addressing the stability of globular proteins. In comparison, advances in the membrane protein folding field lag far behind. Although membrane proteins constitute about a third of the proteins encoded in known genomes, stability studies on membrane proteins have been impaired due to experimental limitations. Furthermore, no systematic experimental strategies are available for folding these biomolecules in vitro. Common denaturing agents such as chaotropes usually do not work on helical membrane proteins, and ionic detergents have been successful denaturants only in few cases. Refolding a membrane protein seems to be a craftsman work, which is relatively straightforward for transmembrane β-barrel proteins but challenging for α-helical membrane proteins. Additional complexities emerge in multidomain membrane proteins, data interpretation being one of the most critical. In this review, we will describe some recent efforts in understanding the folding mechanism of membrane proteins that have been reversibly refolded allowing both thermodynamic and kinetic analysis. This information will be discussed in the context of current paradigms in the protein folding field.

  5. Bifurcation of self-folded polygonal bilayers (United States)

    Abdullah, Arif M.; Braun, Paul V.; Hsia, K. Jimmy


    Motivated by the self-assembly of natural systems, researchers have investigated the stimulus-responsive curving of thin-shell structures, which is also known as self-folding. Self-folding strategies not only offer possibilities to realize complicated shapes but also promise actuation at small length scales. Biaxial mismatch strain driven self-folding bilayers demonstrate bifurcation of equilibrium shapes (from quasi-axisymmetric doubly curved to approximately singly curved) during their stimulus-responsive morphing behavior. Being a structurally instable, bifurcation could be used to tune the self-folding behavior, and hence, a detailed understanding of this phenomenon is appealing from both fundamental and practical perspectives. In this work, we investigated the bifurcation behavior of self-folding bilayer polygons. For the mechanistic understanding, we developed finite element models of planar bilayers (consisting of a stimulus-responsive and a passive layer of material) that transform into 3D curved configurations. Our experiments with cross-linked Polydimethylsiloxane samples that change shapes in organic solvents confirmed our model predictions. Finally, we explored a design scheme to generate gripper-like architectures by avoiding the bifurcation of stimulus-responsive bilayers. Our research contributes to the broad field of self-assembly as the findings could motivate functional devices across multiple disciplines such as robotics, artificial muscles, therapeutic cargos, and reconfigurable biomedical devices.

  6. Andean Basin Evolution Associated with Hybrid Thick- and Thin-Skinned Deformation in the Malargüe Fold-Thrust Belt, Western Argentina (United States)

    Horton, B. K.; Fuentes, F.


    Andean deformation and basin evolution in the Malargüe fold-thrust belt of western Argentina (34-36°S) has been dominated by basement faults influenced by pre-existing Mesozoic rift structures of the hydrocarbon-rich Neuquen basin. However, the basement structures diverge from classic inversion structures, and the associated retroarc basin system shows a complex Mesozoic-Cenozoic history of mixed extension and contraction, along with an enigmatic early Cenozoic stratigraphic hiatus. New results from balanced structural cross sections (supported by industry seismic, well data, and surface maps), U-Pb geochronology, and foreland deposystem analyses provide improved resolution to examine the duration and kinematic evolution of Andean mixed-mode deformation. The basement structures form large anticlines with steep forelimbs and up to >5 km of structural relief. Once the propagating tips of the deeper basement faults reached cover strata, they fed slip to shallow thrust systems that were transported in piggyback fashion by newly formed basement structures, producing complex structural relationships. Detrital zircon U-Pb ages for the 5-7 km-thick basin fill succession reveal shifts in sedimentation pathways and accumulation rates consistent with (1) local basement sources during Early-Middle Jurassic back-arc extension, (2) variable cratonic and magmatic arc sources during Late Jurassic-Cretaceous postrift thermal subsidence, and (3) Andean arc and thrust-belt sources during irregular Late Cretaceous-Cenozoic shortening. Although pulses of flexural subsidence can be attributed to periods of fault reactivation (inversion) and geometrically linked thin-skinned thrusting, fully developed foreland basin conditions were only achieved in Late Cretaceous and Neogene time. Separating these two contractional episodes is an Eocene-lower Miocene (roughly 40-20 Ma) depositional hiatus within the Cenozoic succession, potentially signifying forebulge passage or neutral to

  7. Non-cylindrical fold growth in the Zagros fold and thrust belt (Kurdistan, NE-Iraq) (United States)

    Bartl, Nikolaus; Bretis, Bernhard; Grasemann, Bernhard; Lockhart, Duncan


    The Zagros mountains extends over 1800 km from Kurdistan in N-Iraq to the Strait of Hormuz in Iran and is one of the world most promising regions for the future hydrocarbon exploration. The Zagros Mountains started to form as a result of the collision between the Eurasian and Arabian Plates, whose convergence began in the Late Cretaceous as part of the Alpine-Himalayan orogenic system. Geodetic and seismological data document that both plates are still converging and that the fold and thrust belt of the Zagros is actively growing. Extensive hydrocarbon exploration mainly focuses on the antiforms of this fold and thrust belt and therefore the growth history of the folds is of great importance. This work investigates by means of structural field work and quantitative geomorphological techniques the progressive fold growth of the Permam, Bana Bawi- and Safeen- Anticlines located in the NE of the city of Erbil in the Kurdistan region of Northern Iraq. This part of the Zagros fold and thrust belt belongs to the so-called Simply Folded Belt, which is dominated by gentle to open folding. Faults or fault related folds have only minor importance. The mechanical anisotropy of the formations consisting of a succession of relatively competent (massive dolomite and limestone) and incompetent (claystone and siltstone) sediments essentially controls the deformation pattern with open to gentle parallel folding of the competent layers and flexural flow folding of the incompetent layers. The characteristic wavelength of the fold trains is around 10 km. Due to faster erosion of the softer rock layers in the folded sequence, the more competent lithologies form sharp ridges with steeply sloping sides along the eroded flanks of the anticlines. Using an ASTER digital elevation model in combination with geological field data we quantified 250 drainage basins along the different limbs of the subcylindrical Permam, Bana Bawi- and Safeen- Anticlines. Geomorphological indices of the drainage

  8. The Risk of Vocal Fold Atrophy after Serial Corticosteroid Injections of the Vocal Fold. (United States)

    Shi, Lucy L; Giraldez-Rodriguez, Laureano A; Johns, Michael M


    The aim of this study was to illustrate the risk of vocal fold atrophy in patients who receive serial subepithelial steroid injections for vocal fold scar. This study is a retrospective case report of two patients who underwent a series of weekly subepithelial infusions of 10 mg/mL dexamethasone for benign vocal fold lesion. Shortly after the procedures, both patients developed a weak and breathy voice. The first patient was a 53-year-old man with radiation-induced vocal fold stiffness. Six injections were performed unilaterally, and 1 week later, he developed unilateral vocal fold atrophy with new glottal insufficiency. The second patient was a 67-year-old woman with severe vocal fold inflammation related to laryngitis and calcinosis, Raynaud's phenomenon, esophagean dysmotility, sclerodactyly, and telangiectasia (CREST) syndrome. Five injections were performed bilaterally, and 1 week later, she developed bilateral vocal fold atrophy with a large midline glottal gap during phonation. In both cases, the steroid-induced vocal atrophy resolved spontaneously after 4 months. Serial subepithelial steroid infusions of the vocal folds, although safe in the majority of patients, carry the risk of causing temporary vocal fold atrophy when given at short intervals. Copyright © 2016 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  9. Improvement of a Vocal Fold Imaging System

    Energy Technology Data Exchange (ETDEWEB)

    Krauter, K. G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)


    Medical professionals can better serve their patients through continual update of their imaging tools. A wide range of pathologies and disease may afflict human vocal cords or, as they’re also known, vocal folds. These diseases can affect human speech hampering the ability of the patient to communicate. Vocal folds must be opened for breathing and the closed to produce speech. Currently methodologies to image markers of potential pathologies are difficult to use and often fail to detect early signs of disease. These current methodologies rely on a strobe light and slower frame rate camera in an attempt to obtain images as the vocal folds travel over the full extent of their motion.

  10. Analysis of high-fold gamma data

    International Nuclear Information System (INIS)

    Radford, D. C.; Cromaz, M.; Beyer, C. J.


    Historically, γ-γ and γ-γ-γ coincidence spectra were utilized to build nuclear level schemes. With the development of large detector arrays, it has became possible to analyze higher fold coincidence data sets. This paper briefly reports on software to analyze 4-fold coincidence data sets that allows creation of 4-fold histograms (hypercubes) of at least 1024 channels per side (corresponding to a 43 gigachannel data space) that will fit onto a few gigabytes of disk space, and extraction of triple-gated spectra in a few seconds. Future detector arrays may have even much higher efficiencies, and detect as many as 15 or 20 γ rays simultaneously; such data will require very different algorithms for storage and analysis. Difficulties inherent in the analysis of such data are discussed, and two possible new solutions are presented, namely adaptive list-mode systems and 'list-list-mode' storage

  11. Extreme Mechanics: Self-Folding Origami (United States)

    Santangelo, Christian D.


    Origami has emerged as a tool for designing three-dimensional structures from flat films. Because they can be fabricated by lithographic or roll-to-roll processing techniques, they have great potential for the manufacture of complicated geometries and devices. This article discusses the mechanics of origami and kirigami with a view toward understanding how to design self-folding origami structures. Whether an origami structure can be made to fold autonomously depends strongly on the geometry and kinematics of the origami fold pattern. This article collects some of the results on origami rigidity into a single framework, and discusses how these aspects affect the foldability of origami. Despite recent progress, most problems in origami and origami design remain completely open.

  12. In vitro folding of inclusion body proteins. (United States)

    Rudolph, R; Lilie, H


    Insoluble, inactive inclusion bodies are frequently formed upon recombinant protein production in transformed microorganisms. These inclusion bodies, which contain the recombinant protein in an highly enriched form, can be isolated by solid/liquid separation. After solubilization, native proteins can be generated from the inactive material by using in vitro folding techniques. New folding procedures have been developed for efficient in vitro reconstitution of complex hydrophobic, multidomain, oligomeric, or highly disulfide-bonded proteins. These protocols take into account process parameters such as protein concentration, catalysis of disulfide bond formation, temperature, pH, and ionic strength, as well as specific solvent ingredients that reduce unproductive side reactions. Modification of the protein sequence has been exploited to improve in vitro folding.

  13. Solvent Effects on Protein Folding/Unfolding (United States)

    García, A. E.; Hillson, N.; Onuchic, J. N.

    Pressure effects on the hydrophobic potential of mean force led Hummer et al. to postulate a model for pressure denaturation of proteins in which denaturation occurs by means of water penetration into the protein interior, rather than by exposing the protein hydrophobic core to the solvent --- commonly used to describe temperature denaturation. We study the effects of pressure in protein folding/unfolding kinetics in an off-lattice minimalist model of a protein in which pressure effects have been incorporated by means of the pair-wise potential of mean force of hydrophobic groups in water. We show that pressure slows down the kinetics of folding by decreasing the reconfigurational diffusion coefficient and moves the location of the folding transition state.

  14. Exact folded-band chaotic oscillator. (United States)

    Corron, Ned J; Blakely, Jonathan N


    An exactly solvable chaotic oscillator with folded-band dynamics is shown. The oscillator is a hybrid dynamical system containing a linear ordinary differential equation and a nonlinear switching condition. Bounded oscillations are provably chaotic, and successive waveform maxima yield a one-dimensional piecewise-linear return map with segments of both positive and negative slopes. Continuous-time dynamics exhibit a folded-band topology similar to Rössler's oscillator. An exact solution is written as a linear convolution of a fixed basis pulse and a discrete binary sequence, from which an equivalent symbolic dynamics is obtained. The folded-band topology is shown to be dependent on the symbol grammar.

  15. SDEM modelling of fault-propagation folding

    DEFF Research Database (Denmark)

    Clausen, O.R.; Egholm, D.L.; Poulsen, Jane Bang


    and variations in Mohr-Coulomb parameters including internal friction. Using SDEM modelling, we have mapped the propagation of the tip-line of the fault, as well as the evolution of the fold geometry across sedimentary layers of contrasting rheological parameters, as a function of the increased offset......Understanding the dynamics and kinematics of fault-propagation-folding is important for evaluating the associated hydrocarbon play, for accomplishing reliable section balancing (structural reconstruction), and for assessing seismic hazards. Accordingly, the deformation style of fault-propagation...... a precise indication of when faults develop and hence also the sequential evolution of secondary faults. Here we focus on the generation of a fault -propagated fold with a reverse sense of motion at the master fault, and varying only the dip of the master fault and the mechanical behaviour of the deformed...

  16. Heterochiral Knottin Protein: Folding and Solution Structure. (United States)

    Mong, Surin K; Cochran, Frank V; Yu, Hongtao; Graziano, Zachary; Lin, Yu-Shan; Cochran, Jennifer R; Pentelute, Bradley L


    Homochirality is a general feature of biological macromolecules, and Nature includes few examples of heterochiral proteins. Herein, we report on the design, chemical synthesis, and structural characterization of heterochiral proteins possessing loops of amino acids of chirality opposite to that of the rest of a protein scaffold. Using the protein Ecballium elaterium trypsin inhibitor II, we discover that selective β-alanine substitution favors the efficient folding of our heterochiral constructs. Solution nuclear magnetic resonance spectroscopy of one such heterochiral protein reveals a homogeneous global fold. Additionally, steered molecular dynamics simulation indicate β-alanine reduces the free energy required to fold the protein. We also find these heterochiral proteins to be more resistant to proteolysis than homochiral l-proteins. This work informs the design of heterochiral protein architectures containing stretches of both d- and l-amino acids.

  17. Vascular lesions of the vocal fold. (United States)

    Gökcan, Kürşat Mustafa; Dursun, Gürsel


    The aim of the study was to present symptoms, laryngological findings, clinical course, management modalities, and consequences of vascular lesions of vocal fold. This study examined 162 patients, the majority professional voice users, with vascular lesions regarding their presenting symptoms, laryngological findings, clinical courses and treatment results. The most common complaint was sudden hoarseness with hemorrhagic polyp. Microlaryngoscopic surgery was performed in 108 cases and the main indication of surgery was the presence of vocal fold mass or development of vocal polyp during clinical course. Cold microsurgery was utilized for removal of vocal fold masses and feeding vessels cauterized using low power, pulsed CO(2) laser. Acoustic analysis of patients revealed a significant improvement of jitter, shimmer and harmonics/noise ratio values after treatment. Depending on our clinical findings, we propose treatment algorithm where voice rest and behavioral therapy is the integral part and indications of surgery are individualized for each patient.

  18. Natural triple beta-stranded fibrous folds. (United States)

    Mitraki, Anna; Papanikolopoulou, Katerina; Van Raaij, Mark J


    A distinctive family of beta-structured folds has recently been described for fibrous proteins from viruses. Virus fibers are usually involved in specific host-cell recognition. They are asymmetric homotrimeric proteins consisting of an N-terminal virus-binding tail, a central shaft or stalk domain, and a C-terminal globular receptor-binding domain. Often they are entirely or nearly entirely composed of beta-structure. Apart from their biological relevance and possible gene therapy applications, their shape, stability, and rigidity suggest they may be useful as blueprints for biomechanical design. Folding and unfolding studies suggest their globular C-terminal domain may fold first, followed by a "zipping-up" of the shaft domains. The C-terminal domains appear to be important for registration because peptides corresponding to shaft domains alone aggregate into nonnative fibers and/or amyloid structures. C-terminal domains can be exchanged between different fibers and the resulting chimeric proteins are useful as a way to solve structures of unknown parts of the shaft domains. The following natural triple beta-stranded fibrous folds have been discovered by X-ray crystallography: the triple beta-spiral, triple beta-helix, and T4 short tail fiber fold. All have a central longitudinal hydrophobic core and extensive intermonomer polar and nonpolar interactions. Now that a reasonable body of structural and folding knowledge has been assembled about these fibrous proteins, the next challenge and opportunity is to start using this information in medical and industrial applications such as gene therapy and nanotechnology.

  19. Folding models for elastic and inelastic scattering

    International Nuclear Information System (INIS)

    Satchler, G.R.


    The most widely used models are the optical model potential (OMP) for elastic scattering, and its generalization to non-spherical shapes, the deformed optical model potential (DOMP) for inelastic scattering. These models are simple and phenomenological; their parameters are adjusted so as to reproduce empirical data. Nonetheless, there are certain, not always well-defined, constraints to be imposed. The potential shapes and their parameter values must be reasonable and should vary in a smooth and systematic way with the masses of the colliding nuclei and their energy. One way of satisfying these constraints, without going back to a much more fundamental theory, is through the use of folding models. The basic justification for using potentials of the Woods-Saxon shape for nucleon-nucleus scattering, for example, is our knowledge that a nuclear density distribution is more-or-less constant in the nuclear interior with a diffuse surface. When this is folded with a short-range nucleon-nucleon interaction, the result is a similar shape with a more diffuse surface. Folding procedures allow us to incorporate many aspects of nuclear structure (although the nuclear size is one of the most important), as well as theoretical ideas about the effective interaction of two nucleons within nuclear matter. It also provides us with a means of linking information obtained from nuclear (hadronic) interactions with that from other sources, as well as correlating that from the use of different hadronic probes. Folding model potentials, single-folded potentials, and the double-folding model including applications to heavy-ion scattering are discussed

  20. Laryngeal ultrasound and pediatric vocal fold nodules. (United States)

    Ongkasuwan, Julina; Devore, Danielle; Hollas, Sarah; Jones, Jeremy; Tran, Brandon


    The term vocal fold nodules refers to bilateral thickening of the membranous folds with minimal impairment of the vibratory properties of the mucosa. Nodules are thought to be related to repetitive mechanical stress, associated with voice use patterns. Diagnosis is typically made in the office via either rigid or flexible laryngeal stroboscopy. Depending on the individual child, obtaining an optimal view of the larynx can be difficult if not impossible. Recent advances in high-frequency ultrasonography allows for transcervical examination of laryngeal structures. The goal of this project was to determine if laryngeal ultrasound (LUS) can be used to identify vocal fold nodules in dysphonic children. Prospective case-control study in which the patient acted as his or her own control. Forty-six pediatric patients were recruited for participation in this study; the mean age was 4.8 years. Twenty-three did not have any vocal fold lesions and 23 had a diagnosis of vocal fold nodules on laryngeal stroboscopy. Recorded LUSs were reviewed by two pediatric radiologists who were blinded to the nodule status. There was substantial inter-rater agreement (κ = 0.70, 95% confidence interval [CI]: 0.50-0.89) between the two radiologists regarding the presence of nodules. There was also substantial agreement (κ = 0.87, 95% CI: 0.72-1) between LUS and laryngeal stroboscopy. Sensitivity of LUS was 100% (95% CI: 85%-100%) and specificity was 87% (95% CI: 66%-97%). LUS can be used to identify vocal fold nodules in children with substantial agreement with laryngeal stroboscopy. 3b Laryngoscope, 127:676-678, 2017. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  1. Active shortening, intermontane basin formation, and geomorphic evolution in an orogenic plateau: Central Puna Plateau, NW Argentina (24°37'S, 67°03'W) (United States)

    Strecker, Manfred R.; Alonso, Ricardo N.; Bookhagen, Bodo; Freymark, Jessica; Pingel, Heiko


    The high-elevation Andean Plateau (Altiplano-Puna; 4km) is a first-order morphotectonic province of the Central Andes and constitutes the world's second largest orogenic plateau. While there are many unifying basin characteristics in this region, including internal drainage, semi-arid to arid climate and associated deposition of evaporites, there are notable differences between the northern and southern parts of the plateau. In contrast to the vast basins of the Altiplano (north) and incipient establishment of fluvial connectivity and sediment transport to the foreland, the Puna (south) comprises numerous smaller basins, bordered by reverse-fault bounded ranges up to 6 km high. The plateau is internally drained and fluvial connectivity with the foreland does not exist leading to thick sedimentary basin fills that comprise continental evaporites, volcanic and clastic deposits, typically between 3 and 5 km thick. However, repeated impacts of climate change and superposed tectonic activity in the southern plateau have resulted in further basin differentiation, abandonment or re-arrangement of fluvial networks and impacts on sediment transport. Here we report evidence for sustained contractional tectonic activity in the Pocitos Basin in the southern plateau. On the western margin of the basin fanning of dipping strata and regraded, steeply inclined gravel-covered pediment surfaces and wind gaps associated with gravel derived from distant sources in the west document late Tertiary to Pleistocene growth of an approximately N-S oriented and N plunging anticline. The growth of the eastern limb of this anticline has caused the isolation of a formerly more extensive basin. In addition, Late Pleistocene and Holocene lake shorelines and lacustrine deposits are tilted eastward along the same structure and InSAR measurements of deformed lake terraces document that the fold is growing. Despite widely reported extensional faulting in the southern Puna, we conclude (1) that the

  2. Stretching and folding mechanism in foams

    International Nuclear Information System (INIS)

    Tufaile, Alberto; Pedrosa Biscaia Tufaile, Adriana


    We have described the stretching and folding of foams in a vertical Hele-Shaw cell containing air and a surfactant solution, from a sequence of upside-down flips. Besides the fractal dimension of the foam, we have observed the logistic growth for the soap film length. The stretching and folding mechanism is present during the foam formation, and this mechanism is observed even after the foam has reached its respective maximum fractal dimension. Observing the motion of bubbles inside the foam, large bubbles present power spectrum associated with random walk motion in both directions, while the small bubbles are scattered like balls in a Galton board

  3. Assessment of thyroplasty for vocal fold paralysis

    DEFF Research Database (Denmark)

    Grøntved, Ågot Møller; Faber, Christian; Jakobsen, John


    INTRODUCTION: Thyroplasty with silicone rubber implantation is a surgical procedure for treatment of patients with vocal fold paralysis. The aim of the present study was to evaluate the outcome of the operation and to monitor which of the analyses were the more beneficial. MATERIAL AND METHODS...... because it offers a quantitative measure of the voice capacity and intensity, which are the major problems experienced by patients with vocal fold paralysis. Used together, these tools are highly instrumental in guiding the patient's choice of surgery or no surgery. Udgivelsesdato: 2009-Jan-12...

  4. Stretching and folding mechanism in foams

    Energy Technology Data Exchange (ETDEWEB)

    Tufaile, Alberto [Escola de Artes, Ciencias e Humanidades, Soft Matter Laboratory, Universidade de Sao Paulo, 03828-000 Sao Paulo, SP (Brazil)], E-mail:; Pedrosa Biscaia Tufaile, Adriana [Escola de Artes, Ciencias e Humanidades, Soft Matter Laboratory, Universidade de Sao Paulo, 03828-000 Sao Paulo, SP (Brazil)


    We have described the stretching and folding of foams in a vertical Hele-Shaw cell containing air and a surfactant solution, from a sequence of upside-down flips. Besides the fractal dimension of the foam, we have observed the logistic growth for the soap film length. The stretching and folding mechanism is present during the foam formation, and this mechanism is observed even after the foam has reached its respective maximum fractal dimension. Observing the motion of bubbles inside the foam, large bubbles present power spectrum associated with random walk motion in both directions, while the small bubbles are scattered like balls in a Galton board.

  5. Projected future wave climate in the NW Mediterranean Sea (United States)

    Casas-Prat, M.; Sierra, J. P.


    Projected future regional wave climate scenarios at a high temporal-spatial scale were obtained for the NW Mediterranean Sea, using five combinations of regional-global circulation models. Changes in wave variables were analyzed and related to the variations of the forcing wind projections, while also evaluating the evolution of the presence of the different types of sea states. To assess the significance of the changes produced, a bootstrap-based method was proposed, which accounts for the autocorrelation of data and correctly reproduces the extremes. For the mean climate, relative changes of Hs up to ±10% were obtained, whereas they were around ±20% for the extreme climate. In mean terms, variations of Hs are similar to those associated with wind speed but are enhanced/attenuated, respectively, when fetch conditions are favorable/unfavorable. In general, most notable alterations are not in the Hs magnitude but rather in its direction. In this regard, during the winter season, it is interesting to note that the significant deviations between the results derived from the two global circulation models are larger than those between regional models. ECHAM5 simulated an enhanced west wind flow that is translated into more frequent W-NW waves, whereas the HadCM3Q3 global model gives rise to the east component, which contributes to a higher intensity and number of storms coming from such a direction and directly affects the wind-sea/swell distribution of coastal stretches that face east, like the Catalan coast. Different patterns of change were obtained during the summer when a common rise of NE-E waves was found.

  6. Use of dogs as indicators of metal exposure in rural and urban habitats in NW Spain

    International Nuclear Information System (INIS)

    Lopez-Alonso, M.; Miranda, M.; Garcia-Partida, P.; Cantero, F.; Hernandez, J.; Benedito, J.L.


    Many different species have been used in environmental biomonitoring studies in diverse habitats including forest, farmland, and urban and sub-urban areas. However, there is little information on domestic animals living in rural or urban habitats and exposed to the same pollutants as the human population. In this connection, pets could prove to be good indicators of human metal exposure since they closely share the same environment as their owners, and are therefore exposed, at least in part, to the same pollutants. The present study investigated toxic metal exposure in dogs in NW Spain and compared metal exposures between dogs from rural and urban habitats, considering the influence of diet, sex and age. Samples of liver and kidney from 57 male and female dogs, aged between 6 months and 18 years, were collected after euthanasia at veterinary clinics. Samples were acid-digested and metal concentrations determined by ICP-MS. Geometric mean concentrations of metals in the liver and kidney (μg/kg wet weight) were 12.6 and 15.9 for arsenic, 58.0 and 175 for cadmium, 32.7 and 53.4 for mercury, and 57.7 and 23.1 respectively. Hepatic lead concentrations were significantly higher (p < 0.05) in dogs fed commercial diets than dogs fed home-made feed (32%) or a mixture of commercial and home-made feeds (95%). Mercury concentrations in the kidney were significantly higher (3-fold, p < 0.05) in dogs from urban areas than in dogs from rural areas. Cadmium levels in kidney were significantly higher (p < 0.05) in females (67%) and increased with age (p < 0.001). Although no human samples were obtained in this study and no direct correlations between dogs and human metal exposure have been conducted, given our results pets could be suggested as surrogate indicators of human metal exposure

  7. Use of dogs as indicators of metal exposure in rural and urban habitats in NW Spain

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Alonso, M. [Universidade de Santiago de Compostela, Departamento de Patoloxia Animal, Facultade de Veterinaria, 27002 Lugo (Spain)]. E-mail:; Miranda, M. [Universidade de Santiago de Compostela, Departamento de Ciencias Clinicas Veterinarias, Facultade de Veterinaria, 27002 Lugo (Spain); Garcia-Partida, P. [Universidad Complutense de Madrid, Departamento de Patologia Animal II, Facultad de Veterinaria, 28040 Madrid (Spain); Cantero, F. [Universidade de Santiago de Compostela, Departamento de Patoloxia Animal, Facultade de Veterinaria, 27002 Lugo (Spain); Hernandez, J. [Universidade de Santiago de Compostela, Departamento de Patoloxia Animal, Facultade de Veterinaria, 27002 Lugo (Spain); Benedito, J.L. [Universidade de Santiago de Compostela, Departamento de Patoloxia Animal, Facultade de Veterinaria, 27002 Lugo (Spain)


    Many different species have been used in environmental biomonitoring studies in diverse habitats including forest, farmland, and urban and sub-urban areas. However, there is little information on domestic animals living in rural or urban habitats and exposed to the same pollutants as the human population. In this connection, pets could prove to be good indicators of human metal exposure since they closely share the same environment as their owners, and are therefore exposed, at least in part, to the same pollutants. The present study investigated toxic metal exposure in dogs in NW Spain and compared metal exposures between dogs from rural and urban habitats, considering the influence of diet, sex and age. Samples of liver and kidney from 57 male and female dogs, aged between 6 months and 18 years, were collected after euthanasia at veterinary clinics. Samples were acid-digested and metal concentrations determined by ICP-MS. Geometric mean concentrations of metals in the liver and kidney ({mu}g/kg wet weight) were 12.6 and 15.9 for arsenic, 58.0 and 175 for cadmium, 32.7 and 53.4 for mercury, and 57.7 and 23.1 respectively. Hepatic lead concentrations were significantly higher (p < 0.05) in dogs fed commercial diets than dogs fed home-made feed (32%) or a mixture of commercial and home-made feeds (95%). Mercury concentrations in the kidney were significantly higher (3-fold, p < 0.05) in dogs from urban areas than in dogs from rural areas. Cadmium levels in kidney were significantly higher (p < 0.05) in females (67%) and increased with age (p < 0.001). Although no human samples were obtained in this study and no direct correlations between dogs and human metal exposure have been conducted, given our results pets could be suggested as surrogate indicators of human metal exposure.

  8. Regional polyphase deformation of the Eastern Sierras Pampeanas (Argentina Andean foreland): strengths and weaknesses of paleostress inversion (United States)

    Traforti, Anna; Zampieri, Dario; Massironi, Matteo; Viola, Giulio; Alvarado, Patricia; Di Toro, Giulio


    The Eastern Sierras Pampeanas of central Argentina are composed of a series of basement-cored ranges, located in the Andean foreland c. 600 km east of the Andean Cordillera. Although uplift of the ranges is partly attributed to the regional Neogene evolution (Ramos et al. 2002), many questions remain as to the timing and style of deformation. In fact, the Eastern Sierras Pampeanas show compelling evidence of a long lasting brittle history (spanning the Early Carboniferous to Present time), characterised by several deformation events reflecting different tectonic regimes. Each deformation phase resulted in further strain increments accommodated by reactivation of inherited structures and rheological anisotropies (Martino 2003). In the framework of such a polyphase brittle tectonic evolution affecting highly anisotropic basement rocks, the application of paleostress inversion methods, though powerful, suffers from some shortcomings, such as the likely heterogeneous character of fault slip datasets and the possible reactivation of even highly misoriented structures, and thus requires careful analysis. The challenge is to gather sufficient fault-slip data, to develop a proper understanding of the regional evolution. This is done by the identification of internally consistent fault and fracture subsets (associated to distinct stress states on the basis of their geometric and kinematic compatibility) in order to generate a chronologically-constrained evolutionary conceptual model. Based on large fault-slip datasets collected in the Sierras de Cordoba (Eastern Sierras Pampeanas), reduced stress tensors have been generated and interpreted as part of an evolutionary model by considering the obtained results against: (i) existing K-Ar illite ages of fault gouges in the study area (Bense et al. 2013), (ii) the nature and orientation of pre-existing anisotropies and (iii) the present-day stress field due to the convergence of the Nazca and South America plates (main shortening

  9. 3-D velocity structures, seismicity patterns, and their tectonic implications across the Andean Foreland of San Juan Argentina (United States)

    Asmerom, Biniam Beyene

    Three-dimensional velocity structures and seismicity patterns have been studied across the Andean Foreland of San Juan Argentina using data acquired by PANDA deployment. Distinct velocity variations are revealed between Precordillera in the west and Pie de Palo in the east. The low velocity anomaly beneath Precordillera is associated with the presence of thick sedimentary rocks and thick sediment cover of Matagusanos valley. Similarly, the high velocity anomaly east of Eastern Precordillera is correlated with the presence of basement rocks. These anomalies are observed from the station corrections of Joint Hypocentral Determination (JHD) analysis. A northeast trending west dipping high velocity anomaly is imaged beneath the southern half of Pie de Palo. This anomaly represents a Grenvillian suture zone formed when Pie de Palo collided with the Precordillera. Relocated seismicity using 3-D Vp and Vs models obtained in this study revealed crustal scale buried faults beneath the Eastern Precordillera and Sierra Pie de Palo. The fault defined by the seismicity extend down to a depth of ˜ 40 km and ~35 km beneath Precordillera and Pie de Palo, respectively, defining the lower bound of the brittle to ductile transition of the crust. These results confirm that present day active crustal thickening involves the entire crust in the tectonic process and results in thick-skinned deformation beneath both the Eastern Precordillera and Pie de Palo. Based on the seismicity pattern, geomorphology, and velocity structures, Sierra Pie de Palo, a basement uplift block, can be divided into two separate semi-blocks separated by a northeast trending fracture zone. The northern block is characterized by a well-defined west dipping fault and low Vp/Vs ratio particularly at a depth of 12 to 16 km, while the southern block shows a poorly-defined east dipping fault with high Vp/Vs ratio at a depth of 20 to 26 km. Spatial distribution of the well-relocated crustal earthquakes along these

  10. Folding of multidomain proteins: biophysical consequences of tethering even in apparently independent folding. (United States)

    Arviv, Oshrit; Levy, Yaakov


    Most eukaryotic and a substantial fraction of prokaryotic proteins are composed of more than one domain. The tethering of these evolutionary, structural, and functional units raises, among others, questions regarding the folding process of conjugated domains. Studying the folding of multidomain proteins in silico enables one to identify and isolate the tethering-induced biophysical determinants that govern crosstalks generated between neighboring domains. For this purpose, we carried out coarse-grained and atomistic molecular dynamics simulations of two two-domain constructs from the immunoglobulin-like β-sandwich fold. Each of these was experimentally shown to behave as the "sum of its parts," that is, the thermodynamic and kinetic folding behavior of the constituent domains of these constructs seems to occur independently, with the folding of each domain uncoupled from the folding of its partner in the two-domain construct. We show that the properties of the individual domains can be significantly affected by conjugation to another domain. The tethering may be accompanied by stabilizing as well as destabilizing factors whose magnitude depends on the size of the interface, the length, and the flexibility of the linker, and the relative stability of the domains. Accordingly, the folding of a multidomain protein should not be viewed as the sum of the folding patterns of each of its parts, but rather, it involves abrogating several effects that lead to this outcome. An imbalance between these effects may result in either stabilization or destabilization owing to the tethering. Copyright © 2012 Wiley Periodicals, Inc.

  11. A comparison of RNA folding measures

    DEFF Research Database (Denmark)

    Freyhult, E.; Gardner, P. P.; Moulton, V.


    the behaviour of these measures over a large range of Rfam ncRNA families. Such measures can be useful in, for example, identifying novel ncRNAs, and indicating the presence of alternate RNA foldings. Results Our analysis shows that ncRNAs, but not mRNAs, in general have lower minimal free energy (MFE) than....... Conclusion Due to the correlations between the different measures we find that it is sufficient to use only two of them in RNA folding studies, one to test if the sequence in question has lower energy than a random sequence with the same dinucleotide frequency (the Z-score) and the other to see......Background In the last few decades there has been a great deal of discussion concerning whether or not noncoding RNA sequences (ncRNAs) fold in a more well-defined manner than random sequences. In this paper, we investigate several existing measures for how well an RNA sequence folds, and compare...

  12. Mapping the universe of RNA tetraloop folds

    DEFF Research Database (Denmark)

    Bottaro, Sandro; Lindorff-Larsen, Kresten


    We report a map of RNA tetraloop conformations constructed by calculating pairwise distances among all experimentally determined four-nucleotide hairpin loops. Tetraloops with similar structures are clustered together and, as expected, the two largest clusters are the canonical GNRA and UNCG fold...

  13. Fold in Origami and Unfold Math (United States)

    Georgeson, Joseph


    Students enjoy origami and like making everything from paper cranes to footballs out of small, colorful squares of paper. They can invent their own shapes and are intrigued by the polyhedrons that they can construct. Paper folding is fun, but where is the math? Unless teachers develop lessons that address mathematical objectives, origami could be…

  14. Self-folding graphene-polymer bilayers

    Energy Technology Data Exchange (ETDEWEB)

    Deng, Tao [Institute of Microelectronics, Tsinghua University, Beijing 100084 (China); Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Yoon, ChangKyu [Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Jin, Qianru [Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Li, Mingen [Department of Physics, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Liu, Zewen [Institute of Microelectronics, Tsinghua University, Beijing 100084 (China); Gracias, David H., E-mail: [Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States); Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218 (United States)


    In order to incorporate the extraordinary intrinsic thermal, electrical, mechanical, and optical properties of graphene with three dimensional (3D) flexible substrates, we introduce a solvent-driven self-folding approach using graphene-polymer bilayers. A polymer (SU-8) film was spin coated atop chemically vapor deposited graphene films on wafer substrates and graphene-polymer bilayers were patterned with or without metal electrodes using photolithography, thin film deposition, and etching. After patterning, the bilayers were released from the substrates and they self-folded to form fully integrated, curved, and folded structures. In contrast to planar graphene sensors on rigid substrates, we assembled curved and folded sensors that are flexible and they feature smaller form factors due to their 3D geometry and large surface areas due to their multiple rolled architectures. We believe that this approach could be used to assemble a range of high performance 3D electronic and optical devices of relevance to sensing, diagnostics, wearables, and energy harvesting.

  15. Targeted transtracheal stimulation for vocal fold closure. (United States)

    Hadley, Aaron J; Thompson, Paul; Kolb, Ilya; Hahn, Elizabeth C; Tyler, Dustin J


    Paralysis of the structures in the head and neck due to stroke or other neurological disorder often causes dysphagia (difficulty in swallowing). Patients with dysphagia have a significantly higher incidence of aspiration pneumonia and death. The recurrent laryngeal nerve (RLN), which innervates the intrinsic laryngeal muscles that control the vocal folds, travels superiorly in parallel to the trachea in the tracheoesophageal groove. This study tests the hypothesis that functional electrical stimulation (FES) applied via transtracheal electrodes can produce controlled vocal fold adduction. Bipolar electrodes were placed at 15° intervals around the interior mucosal surface of the canine trachea, and current was applied to the tissue while electromyography (EMG) from the intrinsic laryngeal muscles and vocal fold movement visualization via laryngoscopy were recorded. The lowest EMG thresholds were found at an average location of 100° to the left of the ventral midsagittal line and 128° to the right. A rotatable pair of bipolar electrodes spaced 230° apart were able to stimulate bilaterally both RLNs in every subject. Laryngoscopy showed complete glottal closure with transtracheal stimulation in six of the eight subjects, and this closure was maintained under simultaneous FES-induced laryngeal elevation. Transtracheal stimulation is an effective tool for minimally invasive application of FES to induce vocal fold adduction, providing an alternative mechanism to study airway protection.

  16. Amylose folding under the influence of lipids

    NARCIS (Netherlands)

    Lopez, Cesar A.; de Vries, Alex H.; Marrink, Siewert J.


    The molecular dynamics simulation technique was used to study the folding and complexation process of a short amylose fragment in the presence of lipids. In aqueous solution, the amylose chain remains as an extended left-handed helix. After the addition of lipids in the system, however, we observe


    Directory of Open Access Journals (Sweden)

    Matthias Echternach


    Full Text Available The principal symptoms of unilateral vocal fold paralysis are hoarseness and difficulty in swallowing. Dyspnea is comparatively rare (Laccourreye et al., 2003. The extent to which unilateral vocal fold paralysis may lead to respiratory problems at all - in contrast to bilateral vocal fold paralysis- has not yet well been determined. On the one hand, inspiration is impaired with unilateral vocal fold paralysis; on the other hand, neither the position of the vocal fold paralysis nor the degree of breathiness correlates with respiratory parameters (Cantarella et al., 2003; 2005. The question of what respiratory stress a patient with a vocal fold paresis can endure has not yet been dealt with.A 43 year-old female patient was suffering from recurrent unspecific respiratory complaints for four months after physical activity. During training for a marathon, she experienced no difficulty in breathing. These unspecific respiratory complaints occurred only after athletic activity and persisted for hours. The patient observed neither an increased coughing nor a stridor. Her voice remained unaltered during the attacks, nor were there any signs of a symptomatic gastroesophageal reflux or infectious disease. A cardio-pulmonary and a radiological examination by means of an X-ray of the thorax also revealed no pathological phenomena. As antiallergic and antiobstructive therapy remained unsuccessful, a laryngological examination was performed in order to exclude a vocal cord dysfunction.Surprisingly enough, the laryngostroboscopy showed, as an initial description, a vocal fold paralysis of the left vocal fold in median position (Figure 1. The anamnestic background for the cause was unclear. The only clue was a thoracotomy on the left side due to a pleuritis in childhood. A subsequent laryngoscopic examination had never been performed. Good mucosa waves and amplitudes were shown bilateral with complete glottal closure. Neither in the acoustic analysis, nor in the

  18. Towards a systematic classification of protein folds

    DEFF Research Database (Denmark)

    Lindgård, Per-Anker; Bohr, Henrik


    structures are given a unique name, which simultaneously represent a linear string of physical coupling constants describing hinge spin interactions. We have defined a metric and a precise distance measure between the fold classes. An automated procedure is constructed in which any protein structure...

  19. Vocal fold submucosal infusion technique in phonomicrosurgery. (United States)

    Kass, E S; Hillman, R E; Zeitels, S M


    Phonomicrosurgery is optimized by maximally preserving the vocal fold's layered microstructure (laminae propriae). The technique of submucosal infusion of saline and epinephrine into the superficial lamina propria (SLP) was examined to delineate how, when, and why it was helpful toward this surgical goal. A retrospective review revealed that the submucosal infusion technique was used to enhance the surgery in 75 of 152 vocal fold procedures that were performed over the last 2 years. The vocal fold epithelium was noted to be adherent to the vocal ligament in 29 of the 75 cases: 19 from previous surgical scarring, 4 from cancer, 3 from sulcus vocalis, 2 from chronic hemorrhage, and 1 from radiotherapy. The submucosal infusion technique was most helpful when the vocal fold epithelium required resection and/or when extensive dissection in the SLP was necessary. The infusion enhanced the surgery by vasoconstriction of the microvasculature in the SLP, which improved visualization during cold-instrument tangential dissection. Improved visualization facilitated maximal preservation of the SLP, which is necessary for optimal pliability of the overlying epithelium. The infusion also improved the placement of incisions at the perimeter of benign, premalignant, and malignant lesions, and thereby helped preserve epithelium uninvolved by the disorder.

  20. Climate change consequences for terrestrial ecosystem processes in NW Greeland: Results from the High Arctic Biocomplexity project (United States)

    Welker, J. M.; Sullivan, P.; Rogers, M.; Sharp, E. D.; Sletten, R.; Burnham, J. L.; Hallet, B.; Hagedorn, B.; Czimiczk, C.


    Greenland is experiencing some of the fastest rates of climate warming across the Arctic including warmer summers and increases in snow fall. The effects of these new states of Greenland are however, uncertain especially for carbon, nitrogen and water biogeochemical processes, soil traits, vegetation growth patterns, mineral nutrition and plant ecophysiological processes. Since 2003 we have conducted a suite of observational and experimental measurements that have been designed to understand the fundamental nature of polar desert, polar semi-desert and fen landscapes in NW Greenland. In addition, we have established a suite of experiments to ascertain ecosystem responses to warming at multiple levels (~2030 and 2050), in conjunction with added summer rain; the consequences of added snow fall (ambient, intermediate and deep) and the effects of increases in nutrient additions (added N, P and N+P), which represent extreme warming conditions. We find that: a) the soil C pools are 6-fold larger than previously measured, b) extremely old C (up to ~30k bp) which has been buried by frost cracking and frost heaving is reaching the modern atmosphere, but in only trace amounts as measured by respired 14CO2, c) warming that simulates 2030, has only a small effect on net C sequestration but warming that simulates 2050 when combined with added summer rain, increases C sequestration by 300%, d) increases in N deposition almost immediately and completely changes the vegetation composition of polar semi-deserts shifting the NDVI values from 0.2 to 0.5 within 2 years. Our findings depict a system that is poised to contribute stronger feedbacks than previously expected as climates in NW Greenland change.

  1. Folding and Fracturing of Rocks: the background (United States)

    Ramsay, John G.


    This book was generated by structural geology teaching classes at Imperial College. I was appointed lecturer during 1957 and worked together with Dr Gilbert Wilson teaching basic structural geology at B.Sc level. I became convinced that the subject, being essentially based on geometric field observations, required a firm mathematical basis for its future development. In particular it seemed to me to require a very sound understanding of stress and strain. My field experience suggested that a knowledge of two- and three-demensional strain was critical in understanding natural tectonic processes. I found a rich confirmation for this in early publications of deformed fossils, oolitic limestones and spotted slates made by several geologists around the beginning of the 20th century (Sorby, Philips, Haughton, Harker) often using surprisingly sophisticated mathematical methods. These methods were discussed and elaborated in Folding and Fracturing of Rocks in a practical way. The geometric features of folds were related to folding mechanisms and the fold related small scale structures such as cleavage, schistosity and lineation explained in terms of rock strain. My work in the Scottish Highlands had shown just how repeated fold superposition could produce very complex geometric features, while further work in other localities suggested that such geometric complications are common in many orogenic zones. From the development of structural geological studies over the past decades it seems that the readers of this book have found many of the ideas set out are still of practical application. The mapping of these outcrop-scale structures should be emphasised in all field studies because they can be seen as ''fingerprints'' of regional scale tectonic processes. My own understanding of structural geology has been inspired by field work and I am of the opinion that future progress in understanding will be likewise based on careful observation and measurement of the features of


    Directory of Open Access Journals (Sweden)



    Full Text Available Background: Vocal fold polyp is one of the most common causes for hoarseness. Many different etiological factors contribute to vocal fold polyp formation. The aim of the study was to find out whether the etiological factors for polyp formation have changed in the last 30 years.Methods: Eighty-one patients with unilateral vocal fold polyp were included in the study. A control group was composed of 50 volunteers without voice problems who matched the patients by age and gender. The data about etiological factors and the findings of phoniatric examination were obtained from the patients' medical documentation and from the questionnaires for the control group. The incidence of etiological factors was compared between the two groups. The program SPSS, Version 18 was used for statistical analysis.Results: The most frequent etiological factors were occupational voice load, GER, allergy and smoking. In 79% of patients 2 – 6 contemporary acting risk factors were found. Occupational voice load (p=0,018 and GER (p=0,004 were significantly more frequent in the patients than in the controls. The other factors did not significantly influence the polyp formation.Conclusions: There are several factors involved simultaneously in the formation of vocal fold polyps both nowadays and 30 years ago. Some of the most common factors remain the same (voice load, smoking, others are new (GER, allergy, which is probably due to the different lifestyle and working conditions than 30 years ago. Occupational voice load and GER were significantly more frequently present in the patients with polyp than in the control group. Regarding the given results it is important to instruct workers with professional vocal load about etiological factors for vocal fold polyp formation.

  3. Inverse folding of RNA pseudoknot structures

    Directory of Open Access Journals (Sweden)

    Li Linda YM


    Full Text Available Abstract Background RNA exhibits a variety of structural configurations. Here we consider a structure to be tantamount to the noncrossing Watson-Crick and G-U-base pairings (secondary structure and additional cross-serial base pairs. These interactions are called pseudoknots and are observed across the whole spectrum of RNA functionalities. In the context of studying natural RNA structures, searching for new ribozymes and designing artificial RNA, it is of interest to find RNA sequences folding into a specific structure and to analyze their induced neutral networks. Since the established inverse folding algorithms, RNAinverse, RNA-SSD as well as INFO-RNA are limited to RNA secondary structures, we present in this paper the inverse folding algorithm Inv which can deal with 3-noncrossing, canonical pseudoknot structures. Results In this paper we present the inverse folding algorithm Inv. We give a detailed analysis of Inv, including pseudocodes. We show that Inv allows to design in particular 3-noncrossing nonplanar RNA pseudoknot 3-noncrossing RNA structures-a class which is difficult to construct via dynamic programming routines. Inv is freely available at Conclusions The algorithm Inv extends inverse folding capabilities to RNA pseudoknot structures. In comparison with RNAinverse it uses new ideas, for instance by considering sets of competing structures. As a result, Inv is not only able to find novel sequences even for RNA secondary structures, it does so in the context of competing structures that potentially exhibit cross-serial interactions.

  4. Late Cretaceous to Present evolution of the NW Africa peri-cratonic in the Africa-Eurasia plate convergence context (United States)

    Ghorbal, B.; Bertotti, G.; Andriessen, P. A. M.


    Africa-Eurasia plate convergence is the main mechanism to explain topographic evolution and patterns of Tertiary vertical motions recorded around the entire Mediterranean and even further east. However, most of the studies are concentrated on the Eurasian side of the Mediterranean Realm. Along the NW Africa pericratonic zone (western Mediterranean side) extending longitudinally from the Anti-Atlas to the Rif Mountains, the highest topography is observed in the High Atlas intracontinental belt and in the Pan-African Anti-Atlas belt, and not in the youngest belt, the Rif. The combination of AFT and (U-Th)/He low-thermal dating, performed on pre-Cenozoic basement rocks along the Moroccan pericratonic transect (500km) yield ages ranging respectively between 90-9Ma and 65-7Ma, documenting vertical motions of subsidence and exhumation in between Late Cretaceous and Present. Time-Temperature models show that vertical movements are spatially zoned through Morocco, with the highest amplitude of vertical movements in the High Atlas (>4-5km) and more modest amounts in the Anti-Atlas and the Western Meseta (African peri-cratonic zone including the Western Meseta and the Anti-Atlas in addition to the Atlas and the Rif systems experienced Tertiary deformation. Two stages of folding are distinguished on the basis of low-thermal dating results along the pericratonic transect. The first is a lithospherical folding of ~500km in the Late Cretaceous (confirming that this process is a primary response to recently induced compressional stress fields) and the second is a crustal folding of ~100-150km wavelength in the Late Eocene that occurred independently to the mantle, requiring therefore the existence of a decoupling in between the base of the crust and the high mantle.

  5. When did the Penglai orogeny begin on Taiwan?: Geochronological and petrographic constraints on the exhumed mountain belts and foreland-basin sequences (United States)

    Chen, W. S.; Syu, S. J.; Yeh, J. J.


    Foreland basin receives large amounts of synorogenic infill that is eroded from the adjacent exhumed mountain belt, and therefore provides the important information on exhumation evolution. Furthermore, a complete stratigraphic sequence of Taiwan mountain belt consists of five units of Miocene sedimentary rocks (the Western Foothills and the uppermost sequence on the proto-Taiwan mountain belt), Oligocene argillite (the Hsuehshan Range), Eocene quartzite (the Hsuehshan Range), Eocene-Miocene slate and schist (Backbone Range), and Cretaceous schist (Backbone Range) from top to bottom. Based on the progressive unroofing history, the initiation of foreland basin received sedimentary lithic sediments from the uppermost sequence of proto-Taiwan mountain belt, afterwards, and receiving low- to medium-grade metamorphic lithic sediments in ascending order of argillite, quartzite, slate, and schist clasts. Therefore, the sedimentary lithics from mountain belt were deposited which represents the onset of the mountain uplift. In this study, the first appearance of sedimentary lithic sediments occurs in the Hengchun Peninsula at the middle Miocene (ca. 12-10 Ma). Thus, sandstone petrography of the late Miocene formation (10-5.3 Ma) shows a predominantly recycled sedimentary and low-grade metamorphic sources, including sandstone, argillite and quartzite lithic sediments of 10-25% which records erosion to slightly deeper metamorphic terrane on the mountain belt. Based on the results of previous thermogeochronological studies of the Yuli belt, it suggests that the middle Miocene occurred mountain uplift. The occurrence of low-grade metamorphic lithic sediments in the Hengchun Peninsula during late Miocene is coincident with the cooling ages of uplift and denuded Yuli schist belt at the eastern limb of Backbone Range.

  6. Facies analysis of the Balta Formation: Evidence for a large late Miocene fluvio-deltaic system in the East Carpathian Foreland (United States)

    Matoshko, Anton; Matoshko, Andrei; de Leeuw, Arjan; Stoica, Marius


    Deposits of the Balta Fm are preserved in a large arcuate sediment body that covers about 60,000 km2 and is up to 350 m thick. The Balta Fm spans ca. 5 Ma as constrained by underlying Tortonian (Bessarabian) and overlying Messinian (early Pontian) Paratethys strata. It contains frequent terrestrial mammal fossils and fresh- as well as brackish-water (Paratethys) molluscs and ostracods. Over the past 140 years our understanding of the sedimentary architecture of the formation and its origins has remained in its infancy, which has limited insight into the evolution of the East Carpathian Foreland. Here, we provide the first modern sedimentary facies analysis of the Balta Fm, which is integrated with an extensive review of previously published local literature. It is supported with micropalaeontological results and a wealth of historical borehole information. We show that the Balta Fm has a tripartite vertical division. Its lowermost part is clay dominated and consists of subordinate delta front sand bodies interspersed between muds. The middle unit contains separate delta plain channels or channel belts encased in thick muds. These are overlain by a unit with amalgamated delta plain channel deposits with only minor amounts of associated mud. The abundance of upper flow regime sedimentary structures in channel sands, the absence of peats (or coals) and the presence of calcareous nodules suggest a strongly seasonal and relatively dry climate with a flashy discharge regime. Deposition of the Balta Fm in an area previously characterized by distal shelf and prodelta environments indicates large-scale progradation triggered by high sediment volume from the uplifting Carpathian Orogen and enhanced by a general lowering of Paratethys sea-level. The tripartite internal architecture of the Balta Fm indicates that progradation continued during deposition. Its wedge-shaped geometry suggests that tectonic activity in the Carpathians generated a 300 km wide foreland basin that

  7. Improving protein fold recognition by extracting fold-specific features from predicted residue-residue contacts. (United States)

    Zhu, Jianwei; Zhang, Haicang; Li, Shuai Cheng; Wang, Chao; Kong, Lupeng; Sun, Shiwei; Zheng, Wei-Mou; Bu, Dongbo


    Accurate recognition of protein fold types is a key step for template-based prediction of protein structures. The existing approaches to fold recognition mainly exploit the features derived from alignments of query protein against templates. These approaches have been shown to be successful for fold recognition at family level, but usually failed at superfamily/fold levels. To overcome this limitation, one of the key points is to explore more structurally informative features of proteins. Although residue-residue contacts carry abundant structural information, how to thoroughly exploit these information for fold recognition still remains a challenge. In this study, we present an approach (called DeepFR) to improve fold recognition at superfamily/fold levels. The basic idea of our approach is to extract fold-specific features from predicted residue-residue contacts of proteins using deep convolutional neural network (DCNN) technique. Based on these fold-specific features, we calculated similarity between query protein and templates, and then assigned query protein with fold type of the most similar template. DCNN has showed excellent performance in image feature extraction and image recognition; the rational underlying the application of DCNN for fold recognition is that contact likelihood maps are essentially analogy to images, as they both display compositional hierarchy. Experimental results on the LINDAHL dataset suggest that even using the extracted fold-specific features alone, our approach achieved success rate comparable to the state-of-the-art approaches. When further combining these features with traditional alignment-related features, the success rate of our approach increased to 92.3%, 82.5% and 78.8% at family, superfamily and fold levels, respectively, which is about 18% higher than the state-of-the-art approach at fold level, 6% higher at superfamily level and 1% higher at family level. An independent assessment on SCOP_TEST dataset showed consistent

  8. Late-Miocene thrust fault-related folding in the northern Tibetan Plateau: Insight from paleomagnetic and structural analyses of the Kumkol basin (United States)

    Lu, Haijian; Fu, Bihong; Shi, Pilong; Xue, Guoliang; Li, Haibing


    Constraints on the timing and style of the Tibetan Plateau growth help spur new understanding of the tectonic evolution of the northern Tibetan Plateau and its relation to the India-Asia continental collision. In this regard, records of tectonic deformation with accurate ages are urgently needed, especially in regions without relevant studies. The Kumkol basin, located between two major intermontane basins (the Hoh Xil and Qaidam basins), may hold clues to how these major basins evolve during the Cenozoic. However, little has been known about the exact ages of the strata and tectonic deformation of the basin. Herein, detailed paleomagnetic and structural studies are conducted on the southern Baiquanhe section in the central Kumkol basin, northern Tibetan Plateau. The magnetostratigraphic study indicates that the southern Baiquanhe section spans a time interval of 8.2-4.2 Ma. Well-preserved growth strata date to 7.5 Ma, providing evidence for a significant thrust fault-related folding. This thrust-related folding has also been identified in the Tian Shan foreland and in the northern Tibetan Plateau, most likely implying a pulsed basinward deformation during the late Miocene.

  9. Ca-Dependent Folding of Human Calumenin (United States)

    Mazzorana, Marco; Hussain, Rohanah; Sorensen, Thomas


    Human calumenin (hCALU) is a six EF-hand protein belonging to the CREC family. As other members of the family, it is localized in the secretory pathway and regulates the activity of SERCA2a and of the ryanodine receptor in the endoplasmic reticulum (ER). We have studied the effects of Ca2+ binding to the protein and found it to attain a more compact structure upon ion binding. Circular Dichroism (CD) measurements suggest a major rearrangement of the protein secondary structure, which reversibly switches from disordered at low Ca2+ concentrations to predominantly alpha-helical when Ca2+ is added. SAXS experiments confirm the transition from an unfolded to a compact structure, which matches the structural prediction of a trilobal fold. Overall our experiments suggest that calumenin is a Ca2+ sensor, which folds into a compact structure, capable of interacting with its molecular partners, when Ca2+ concentration within the ER reaches the millimolar range. PMID:26991433

  10. Self-folding micropatterned polymeric containers. (United States)

    Azam, Anum; Laflin, Kate E; Jamal, Mustapha; Fernandes, Rohan; Gracias, David H


    We demonstrate self-folding of precisely patterned, optically transparent, all-polymeric containers and describe their utility in mammalian cell and microorganism encapsulation and culture. The polyhedral containers, with SU-8 faces and biodegradable polycaprolactone (PCL) hinges, spontaneously assembled on heating. Self-folding was driven by a minimization of surface area of the liquefying PCL hinges within lithographically patterned two-dimensional (2D) templates. The strategy allowed for the fabrication of containers with variable polyhedral shapes, sizes and precisely defined porosities in all three dimensions. We provide proof-of-concept for the use of these polymeric containers as encapsulants for beads, chemicals, mammalian cells and bacteria. We also compare accelerated hinge degradation rates in alkaline solutions of varying pH. These optically transparent containers resemble three-dimensional (3D) micro-Petri dishes and can be utilized to sustain, monitor and deliver living biological components.

  11. Dynamics in thin folded polymer films (United States)

    Croll, Andrew; Rozairo, Damith

    Origami and Kirigami inspired structures depend on a complex interplay between geometry and material properties. While clearly important to the overall function, very little attention has focused on how extreme curvatures and singularities in real materials influence the overall dynamic behaviour of folded structures. In this work we use a set of three polymer thin films in order to closely examine the interaction of material and geometry. Specifically, we use polydimethylsiloxane (PDMS), polystyrene (PS) and polycarbonate (PC) thin films which we subject to loading in several model geometries of varying complexity. Depending on the material, vastly different responses are noted in our experiments; D-cones can annihilate, cut or lead to a crumpling cascade when pushed through a film. Remarkably, order can be generated with additional perturbation. Finally, the role of adhesion in complex folded structures can be addressed. AFOSR under the Young Investigator Program (FA9550-15-1-0168).

  12. Folding pathways explored with artificial potential functions

    International Nuclear Information System (INIS)

    Ulutaş, B; Bozma, I; Haliloglu, T


    This paper considers the generation of trajectories to a given protein conformation and presents a novel approach based on artificial potential functions—originally proposed for multi-robot navigation. The artificial potential function corresponds to a simplified energy model, but with the novelty that—motivated by work on robotic navigation—a nonlinear compositional scheme of constructing the energy model is adapted instead of an additive formulation. The artificial potential naturally gives rise to a dynamic system for the protein structure that ensures collision-free motion to an equilibrium point. In cases where the equilibrium point is the native conformation, the motion trajectory corresponds to the folding pathway. This framework is used to investigate folding in a variety of protein structures, and the results are compared with those of other approaches including experimental studies

  13. Folded membrane dialyzer with mechanically sealed edges

    Energy Technology Data Exchange (ETDEWEB)

    Markley, F.W.

    A semipermeable membrane is folded in accordion fashion to form a stack of pleats and the edges are sealed so as to isolate the opposite surfaces of the membrane. The stack is contained within a case that provides ports for flow of blood in contact with one surface of the membrane through channels formed by the pleats and also provides ports for flow of a dialysate through channels formed by the pleats in contact with the other surface of the membrane. The serpentine side edges of the membrane are sealed by a solidified plastic material, whereas effective mechanical means are provided to seal the end edges of the folded membrane. The mechanical means include a clamping strip which biases case sealing flanges into a sealed relationship with end portions of the membrane near the end edges, which portions extend from the stack and between the sealing flanges.

  14. PREFACE Protein folding: lessons learned and new frontiers Protein folding: lessons learned and new frontiers (United States)

    Pappu, Rohit V.; Nussinov, Ruth


    In appropriate physiological milieux proteins spontaneously fold into their functional three-dimensional structures. The amino acid sequences of functional proteins contain all the information necessary to specify the folds. This remarkable observation has spawned research aimed at answering two major questions. (1) Of all the conceivable structures that a protein can adopt, why is the ensemble of native-like structures the most favorable? (2) What are the paths by which proteins manage to robustly and reproducibly fold into their native structures? Anfinsen's thermodynamic hypothesis has guided the pursuit of answers to the first question whereas Levinthal's paradox has influenced the development of models for protein folding dynamics. Decades of work have led to significant advances in the folding problem. Mean-field models have been developed to capture our current, coarse grain understanding of the driving forces for protein folding. These models are being used to predict three-dimensional protein structures from sequence and stability profiles as a function of thermodynamic and chemical perturbations. Impressive strides have also been made in the field of protein design, also known as the inverse folding problem, thereby testing our understanding of the determinants of the fold specificities of different sequences. Early work on protein folding pathways focused on the specific sequence of events that could lead to a simplification of the search process. However, unifying principles proved to be elusive. Proteins that show reversible two-state folding-unfolding transitions turned out to be a gift of natural selection. Focusing on these simple systems helped researchers to uncover general principles regarding the origins of cooperativity in protein folding thermodynamics and kinetics. On the theoretical front, concepts borrowed from polymer physics and the physics of spin glasses led to the development of a framework based on energy landscape theories. These

  15. Image Analysis for Nail-fold Capillaroscopy


    Vucic, Vladimir


    Detection of diseases in an early stage is very important since it can make the treatment of patients easier, safer and more ecient. For the detection of rheumatic diseases, and even prediction of tendencies towards such diseases, capillaroscopy is becoming an increasingly recognized method. Nail-fold capillaroscopy is a non-invasive imaging technique that is used for analysis of microcirculation abnormalities that may lead todisease like systematic sclerosis, Reynauds phenomenon and others. ...

  16. Coherent topological phenomena in protein folding

    DEFF Research Database (Denmark)

    Bohr, Henrik; Brunak, Søren; Bohr, Jakob


    A theory is presented for coherent topological phenomena in protein dynamics with implications for protein folding and stability. We discuss the relationship to the writhing number used in knot diagrams of DNA. The winding state defines a long-range order along the backbone of a protein with long......-range excitations, `wring' modes, that play an important role in protein denaturation and stability. Energy can be pumped into these excitations, either thermally or by an external force....

  17. Evolution of a protein folding nucleus. (United States)

    Xia, Xue; Longo, Liam M; Sutherland, Mason A; Blaber, Michael


    The folding nucleus (FN) is a cryptic element within protein primary structure that enables an efficient folding pathway and is the postulated heritable element in the evolution of protein architecture; however, almost nothing is known regarding how the FN structurally changes as complex protein architecture evolves from simpler peptide motifs. We report characterization of the FN of a designed purely symmetric β-trefoil protein by ϕ-value analysis. We compare the structure and folding properties of key foldable intermediates along the evolutionary trajectory of the β-trefoil. The results show structural acquisition of the FN during gene fusion events, incorporating novel turn structure created by gene fusion. Furthermore, the FN is adjusted by circular permutation in response to destabilizing functional mutation. FN plasticity by way of circular permutation is made possible by the intrinsic C3 cyclic symmetry of the β-trefoil architecture, identifying a possible selective advantage that helps explain the prevalence of cyclic structural symmetry in the proteome. © 2015 The Protein Society.

  18. Folding Membrane Proteins by Deep Transfer Learning

    KAUST Repository

    Wang, Sheng


    Computational elucidation of membrane protein (MP) structures is challenging partially due to lack of sufficient solved structures for homology modeling. Here, we describe a high-throughput deep transfer learning method that first predicts MP contacts by learning from non-MPs and then predicts 3D structure models using the predicted contacts as distance restraints. Tested on 510 non-redundant MPs, our method has contact prediction accuracy at least 0.18 better than existing methods, predicts correct folds for 218 MPs, and generates 3D models with root-mean-square deviation (RMSD) less than 4 and 5 Å for 57 and 108 MPs, respectively. A rigorous blind test in the continuous automated model evaluation project shows that our method predicted high-resolution 3D models for two recent test MPs of 210 residues with RMSD ∼2 Å. We estimated that our method could predict correct folds for 1,345–1,871 reviewed human multi-pass MPs including a few hundred new folds, which shall facilitate the discovery of drugs targeting at MPs.

  19. Protein Folding: Search for Basic Physical Models

    Directory of Open Access Journals (Sweden)

    Ivan Y. Torshin


    Full Text Available How a unique three-dimensional structure is rapidly formed from the linear sequence of a polypeptide is one of the important questions in contemporary science. Apart from biological context of in vivo protein folding (which has been studied only for a few proteins, the roles of the fundamental physical forces in the in vitro folding remain largely unstudied. Despite a degree of success in using descriptions based on statistical and/or thermodynamic approaches, few of the current models explicitly include more basic physical forces (such as electrostatics and Van Der Waals forces. Moreover, the present-day models rarely take into account that the protein folding is, essentially, a rapid process that produces a highly specific architecture. This review considers several physical models that may provide more direct links between sequence and tertiary structure in terms of the physical forces. In particular, elaboration of such simple models is likely to produce extremely effective computational techniques with value for modern genomics.

  20. Hierarchical Diagnosis of Vocal Fold Disorders (United States)

    Nikkhah-Bahrami, Mansour; Ahmadi-Noubari, Hossein; Seyed Aghazadeh, Babak; Khadivi Heris, Hossein

    This paper explores the use of hierarchical structure for diagnosis of vocal fold disorders. The hierarchical structure is initially used to train different second-level classifiers. At the first level normal and pathological signals have been distinguished. Next, pathological signals have been classified into neurogenic and organic vocal fold disorders. At the final level, vocal fold nodules have been distinguished from polyps in organic disorders category. For feature selection at each level of hierarchy, the reconstructed signal at each wavelet packet decomposition sub-band in 5 levels of decomposition with mother wavelet of (db10) is used to extract the nonlinear features of self-similarity and approximate entropy. Also, wavelet packet coefficients are used to measure energy and Shannon entropy features at different spectral sub-bands. Davies-Bouldin criterion has been employed to find the most discriminant features. Finally, support vector machines have been adopted as classifiers at each level of hierarchy resulting in the diagnosis accuracy of 92%.

  1. Thermostability in endoglucanases is fold-specific (United States)


    Background Endoglucanases are usually considered to be synergistically involved in the initial stages of cellulose breakdown-an essential step in the bioprocessing of lignocellulosic plant materials into bioethanol. Despite their economic importance, we currently lack a basic understanding of how some endoglucanases can sustain their ability to function at elevated temperatures required for bioprocessing, while others cannot. In this study, we present a detailed comparative analysis of both thermophilic and mesophilic endoglucanases in order to gain insights into origins of thermostability. We analyzed the sequences and structures for sets of endoglucanase proteins drawn from the Carbohydrate-Active enZymes (CAZy) database. Results Our results demonstrate that thermophilic endoglucanases and their mesophilic counterparts differ significantly in their amino acid compositions. Strikingly, these compositional differences are specific to protein folds and enzyme families, and lead to differences in intramolecular interactions in a fold-dependent fashion. Conclusions Here, we provide fold-specific guidelines to control thermostability in endoglucanases that will aid in making production of biofuels from plant biomass more efficient. PMID:21291533

  2. Thermostability in endoglucanases is fold-specific

    Directory of Open Access Journals (Sweden)

    Wolt Jeffrey D


    Full Text Available Abstract Background Endoglucanases are usually considered to be synergistically involved in the initial stages of cellulose breakdown-an essential step in the bioprocessing of lignocellulosic plant materials into bioethanol. Despite their economic importance, we currently lack a basic understanding of how some endoglucanases can sustain their ability to function at elevated temperatures required for bioprocessing, while others cannot. In this study, we present a detailed comparative analysis of both thermophilic and mesophilic endoglucanases in order to gain insights into origins of thermostability. We analyzed the sequences and structures for sets of endoglucanase proteins drawn from the Carbohydrate-Active enZymes (CAZy database. Results Our results demonstrate that thermophilic endoglucanases and their mesophilic counterparts differ significantly in their amino acid compositions. Strikingly, these compositional differences are specific to protein folds and enzyme families, and lead to differences in intramolecular interactions in a fold-dependent fashion. Conclusions Here, we provide fold-specific guidelines to control thermostability in endoglucanases that will aid in making production of biofuels from plant biomass more efficient.

  3. Wrinkles, folds, and plasticity in granular rafts (United States)

    Jambon-Puillet, Etienne; Josserand, Christophe; Protière, Suzie


    We investigate the mechanical response of a compressed monolayer of large and dense particles at a liquid-fluid interface: a granular raft. Upon compression, rafts first wrinkle; then, as the confinement increases, the deformation localizes in a unique fold. This characteristic buckling pattern is usually associated with floating elastic sheets, and as a result, particle laden interfaces are often modeled as such. Here, we push this analogy to its limits by comparing quantitative measurements of the raft morphology to a theoretical continuous elastic model of the interface. We show that, although powerful to describe the wrinkle wavelength, the wrinkle-to-fold transition, and the fold shape, this elastic description does not capture the finer details of the experiment. We describe an unpredicted secondary wavelength, a compression discrepancy with the model, and a hysteretic behavior during compression cycles, all of which are a signature of the intrinsic discrete and frictional nature of granular rafts. It suggests also that these composite materials exhibit both plastic transition and jamming dynamics.

  4. Araguaia fold belt, new geochronological data

    International Nuclear Information System (INIS)

    Lafon, J.M.; Macambira, J.B.; Macambira, M.J.B.; Moura, C.A.V.; Souza, A.C.C.


    The northern part of the Araguaia Fold Belt (AFB) outcrops in a N-S direction for about 400 km in the state of Tocantins. Dome-like structures occur in this fold belt also in a N-S direction. Both deformation and metamorphism increase from the West to the East. The basement of the AFB consist of Colmeia complex and Cantao gneiss, which crop out mainly in the core of the dome-like structures. The supracrustals rocks of the fold belt belongs to the Baixo Araguaia supergroup which is divided into the lower Estrondo group and the upper Tocantins group. Preliminary Sm-Nd data from the Colmeia complex (Grota Rica dome) gave Archean model ages of 2.8 Ga (TNd sub(DM)) while Rb-Sr data in the same rocks give an age of 2530 ± 200 Ma. In the others dome-like structures, the Rb-Sr systematics gave ages for the Colmeia a complex of 2239 ± 47 Ma (Colmeia structure) and 1972 ± 46 Ma (Lontra structure). These younger ages are believed to represent partial to total isotopic resetting of the Rb-Sr system during the Transamazonian Event. The Rb-Sr studies of the Cantao gneiss gave an age of 1774 ± 31 Ma. (author)

  5. CRED REA Algal Assessments at Necker, NW Hawaiian Islands in 2006 (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Twelve quadrats were sampled along 2 consecutively-placed, 25m transect lines, as part of Rapid Ecological Assessments, conducted at 2 sites at Necker in the NW...

  6. CRED REA Fish Team Belt Transect Survey at Maro Reef, NW Hawaiian Islands, 2006 (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Belt transects along 3 consecutively-placed, 25m transect lines were surveyed as part of Rapid Ecological Assessments conducted at 9 sites at Maro Reef in the NW...

  7. CRED REA Coral Population Parameters at Kure Atoll, NW Hawaiian Islands (NWHI), 2006 (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Belt transects along 2 consecutively-placed, 25m transect lines were surveyed as part of Rapid Ecological Assessments conducted at 9 sites at Kure Atoll in the NW...

  8. CRED REA Algal Assessments at Maro Reef, NW Hawaiian Islands in 2006 (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Twelve quadrats were sampled along 2 consecutively-placed, 25m transect lines, as part of Rapid Ecological Assessments, conducted at 9 sites at Maro Reef in the NW...

  9. CRED REA Algal Assessments at Laysan, NW Hawaiian Islands in 2006 (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Twelve quadrats were sampled along 2 consecutively-placed, 25m transect lines, as part of Rapid Ecological Assessments, conducted at 3 sites at Laysan in the NW...

  10. The Cape Ghir filament system in August 2009 (NW Africa) (United States)

    Sangrà, Pablo; Troupin, Charles; Barreiro-González, Beatriz; Desmond Barton, Eric; Orbi, Abdellatif; Arístegui, Javier


    In the framework of the Canaries-Iberian marine ecosystem Exchanges (CAIBEX) experiment, an interdisciplinary high-resolution survey was conducted in the NW African region of Cape Ghir (30°38'N) during August 2009. The anatomy of a major filament is investigated on scales down to the submesoscale using in situ and remotely sensed data. The filament may be viewed as a system composed of three intimately connected structures: a small, shallow, and cold filament embedded within a larger, deeper, and cool filament and an intrathermocline anticyclonic eddy (ITE). The cold filament, which stretches 110 km offshore, is a shallow feature 60 m deep and 25 km wide, identified by minimal surface temperatures and rich in chlorophyll a. This structure comprises two asymmetrical submesoscale (˜18 km) fronts with jets flowing in opposite directions. The cold filament is embedded near the equatorward boundary of a much broader region of approximately 120 km width and 150 m depth that forms the cool filament and stretches at least 200 km offshore. This cool region, partly resulting from the influence of cold filament, is limited by two asymmetrical mesoscale (˜50 km) frontal boundaries. At the ITE, located north of the cold filament, we observe evidence of downwelling as indicated by a relatively high concentration of particles extending from the surface to more than 200 m depth. We hypothesize that this ITE may act as a sink of carbon and thus the filament system may serve dual roles of offshore carbon export and carbon sink.

  11. Functional results after external vocal fold medialization thyroplasty with the titanium vocal fold medialization implant. (United States)

    Schneider, Berit; Denk, Doris-Maria; Bigenzahn, Wolfgang


    A persistent insufficiency of glottal closure is mostly a consequence of a unilateral vocal fold movement impairment. It can also be caused by vocal fold atrophy or scarring processes with regular bilateral respiratory vocal fold function. Because of consequential voice, breathing, and swallowing impairments, a functional surgical treatment is required. The goal of the study was to outline the functional results after medialization thyroplasty with the titanium vocal fold medialization implant according to Friedrich. In the period of 1999 to 2001, an external vocal fold medialization using the titanium implant was performed on 28 patients (12 women and 16 men). The patients were in the age range of 19 to 84 years. Twenty-two patients had a paralysis of the left-side vocal fold, and six patients, of the right-side vocal fold. Detailed functional examinations were executed on all patients before and after the surgery: perceptive voice sound analysis according to the "roughness, breathiness, and hoarseness" method, judgment of the s/z ratio and voice dysfunction index, voice range profile measurements, videostroboscopy, and pulmonary function tests. In case of dysphagia/aspiration, videofluoroscopy of swallowing was also performed. The respective data were statistically analyzed (paired t test, Wilcoxon-test). All patients reported on improvement of voice, swallowing, and breathing functions postoperatively. Videostroboscopy revealed an almost complete glottal closure after surgery in all of the patients. All voice-related parameters showed a significant improvement. An increase of the laryngeal resistance by the medialization procedure could be excluded by analysis of the pulmonary function test. The results confirm the external medialization of the vocal folds as an adequate method in the therapy of voice, swallowing, and breathing impairment attributable to an insufficient glottal closure. The titanium implant offers, apart from good tissue tolerability, the

  12. Glass ionomer application for vocal fold augmentation: Histopathological analysis on rabbit vocal fold. (United States)

    Demirci, Sule; Tuzuner, Arzu; Callıoglu, Elif Ersoy; Yumusak, Nihat; Arslan, Necmi; Baltacı, Bülent


    The aim of this study was to investigate the use of glass ionomer cement (GIC) as an injection material for vocal fold augmentation and to evaluate the biocompatibility of the material. Ten adult New Zealand rabbits were used. Under general anesthesia, 0.1-cc GIC was injected to one vocal fold and the augmentation of vocal fold was observed. No injection was applied to the opposite side, which was accepted as the control group. The animals were sacrificed after 3 months and the laryngeal specimens were histopathologically evaluated. The injected and the noninjected control vocal folds were analyzed. The GIC particles were observed in histological sections on the injected side, and no foreign body giant cells, granulomatous inflammation, necrosis, or marked chronic inflammation were detected around the glass ionomer particles. Mild inflammatory reactions were noticed in only two specimens. The noninjected sides of vocal folds were completely normal. The findings of this study suggest that GIC is biocompatible and may be further investigated as an alternative injection material for augmentation of the vocal fold. Further studies are required to examine the viscoelastic properties of GIC and the long-term effects in experimental studies. NA. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

  13. Easily fabricated and lightweight PPy/PDA/AgNW composites for excellent electromagnetic interference shielding. (United States)

    Wang, Yan; Gu, Fu-Qiang; Ni, Li-Juan; Liang, Kun; Marcus, Kyle; Liu, Shu-Li; Yang, Fan; Chen, Jin-Ju; Feng, Zhe-Sheng


    Conductive polymer composites (CPCs) containing nanoscale conductive fillers have been widely studied for their potential use in various applications. In this paper, polypyrrole (PPy)/polydopamine (PDA)/silver nanowire (AgNW) composites with high electromagnetic interference (EMI) shielding performance, good adhesion ability and light weight are successfully fabricated via a simple in situ polymerization method followed by a mixture process. Benefiting from the intrinsic adhesion properties of PDA, the adhesion ability and mechanical properties of the PPy/PDA/AgNW composites are significantly improved. The incorporation of AgNWs endows the functionalized PPy with tunable electrical conductivity and enhanced EMI shielding effectiveness (SE). By adjusting the AgNW loading degree in the PPy/PDA/AgNW composites from 0 to 50 wt%, the electrical conductivity of the composites greatly increases from 0.01 to 1206.72 S cm -1 , and the EMI SE of the composites changes from 6.5 to 48.4 dB accordingly (8.0-12.0 GHz, X-band). Moreover, due to the extremely low density of PPy, the PPy/PDA/AgNW (20 wt%) composites show a superior light weight of 0.28 g cm -3 . In general, it can be concluded that the PPy/PDA/AgNW composites with tunable electrical conductivity, good adhesion properties and light weight can be used as excellent EMI shielding materials.

  14. A Rat Excised Larynx Model of Vocal Fold Scar (United States)

    Welham, Nathan V.; Montequin, Douglas W.; Tateya, Ichiro; Tateya, Tomoko; Choi, Seong Hee; Bless, Diane M.


    Purpose: To develop and evaluate a rat excised larynx model for the measurement of acoustic, aerodynamic, and vocal fold vibratory changes resulting from vocal fold scar. Method: Twenty-four 4-month-old male Sprague-Dawley rats were assigned to 1 of 4 experimental groups: chronic vocal fold scar, chronic vocal fold scar treated with 100-ng basic…

  15. Seasonal patterns in phytoplankton photosynthetic parameters and primary production at a coastal NW Mediterranean site

    Directory of Open Access Journals (Sweden)

    Josep M. Gasol


    Full Text Available We carried out monthly photosynthesis-irradiance (P-E experiments with the 14C-method for 12 years (2003–2014 to determine the photosynthetic parameters and primary production of surface phytoplankton in the Blanes Bay Microbial Observatory, a coastal sampling station in the NW Mediterranean Sea. Our goal was to obtain seasonal trends and to establish the basis for detecting future changes of primary production in this oligotrophic area. The maximal photosynthetic rate PBmax ranged 30-fold (0.5-15 mg C mg Chl a–1 h–1, averaged 3.7 mg C mg Chl a–1 h–1 (±0.25 SE and was highest in August and lowest in April and December. We only observed photoinhibition twice. The initial or light-limited slope of the P-E relationship, αB, was low, averaging 0.007 mg C mg Chl a–1 h–1 (μmol photons m–2 s–1–1 (±0.001 SE, range 0.001-0.045 and showed the lowest values in spring (April-June. The light saturation parameter or saturation irradiance, EK, averaged 711 μmol photons m–2 s–1 (± 58.4 SE and tended to be higher in spring and lower in winter. Phytoplankton assemblages were typically dominated by picoeukaryotes in early winter, diatoms in late autumn and late winter, dinoflagellates in spring and cyanobacteria in summer. Total particulate primary production averaged 1.45 mg C m-3 h–1 (±0.13 SE with highest values in winter (up to 8.50 mg C m-3 h–1 and lowest values in summer (summer average, 0.30 mg C m-3 h–1, while chlorophyll-specific primary production averaged 2.49 mg C mg Chl a–1 h–1 (±0.19, SE and peaked in summer (up to 12.0 mg C mg Chl a–1 h–1 in August. 14C-determined phytoplankton growth rates varied between ca. 0.3 d–1 in winter and 0.5 d–1 in summer and were within 60-80% of the maximal rates of growth, based on PBmax. Chlorophyll a was a good predictor of primary production only in the winter and autumn. Seasonality appeared to explain most of the variability in the studied variables, while

  16. Seasonal patterns in phytoplankton photosynthetic parameters and primary production at a coastal NW Mediterranean site

    KAUST Repository

    Gasol, Josep M.


    We carried out monthly photosynthesis-irradiance (P-E) experiments with the 14C-method for 12 years (2003–2014) to determine the photosynthetic parameters and primary production of surface phytoplankton in the Blanes Bay Microbial Observatory, a coastal sampling station in the NW Mediterranean Sea. Our goal was to obtain seasonal trends and to establish the basis for detecting future changes of primary production in this oligotrophic area. The maximal photosynthetic rate PBmax ranged 30-fold (0.5-15 mg C mg Chl a–1 h–1), averaged 3.7 mg C mg Chl a–1 h–1 (±0.25 SE) and was highest in August and lowest in April and December. We only observed photoinhibition twice. The initial or light-limited slope of the P-E relationship, αB, was low, averaging 0.007 mg C mg Chl a–1 h–1 (μmol photons m–2 s–1)–1 (±0.001 SE, range 0.001-0.045) and showed the lowest values in spring (April-June). The light saturation parameter or saturation irradiance, EK, averaged 711 μmol photons m–2 s–1 (±58.4 SE) and tended to be higher in spring and lower in winter. Phytoplankton assemblages were typically dominated by picoeukaryotes in early winter, diatoms in late autumn and late winter, dinoflagellates in spring and cyanobacteria in summer. Total particulate primary production averaged 1.45 mg C m–3 h–1 (±0.13 SE) with highest values in winter (up to 8.50 mg C m–3 h–1) and lowest values in summer (summer average, 0.30 mg C m–3 h–1), while chlorophyll-specific primary production averaged 2.49 mg C mg Chl a–1 h–1 (±0.19, SE) and peaked in summer (up to 12.0 mg C mg Chl a–1 h–1 in August). 14C-determined phytoplankton growth rates varied between ca. 0.3 d–1 in winter and 0.5 d–1 in summer and were within 60-80% of the maximal rates of growth, based on PBmax. Chlorophyll a was a good predictor of primary production only in the winter and autumn. Seasonality appeared to explain most of the variability in the studied variables, while

  17. Calcite twinning strain variations across the Proterozoic Grenville orogen and Keweenaw-Kapuskasing inverted foreland, USA and Canada

    Directory of Open Access Journals (Sweden)

    John P. Craddock


    Full Text Available We report the calcite twinning strain results of a traverse across the Grenville orogen from Parry Sound, Ontario (NW to Ft. Ann, New York (SE, including the younger, adjacent Ordovician Taconic allochthon. Fifty four carbonates (marbles, calcite veins, Ordovician limestone were collected resulting in 68 strain analyses on mechanically twinned calcite (n = 2337 grains across the Central Gneiss Belt (CGB; 3 samples, the Central Metasedimentary Belt (CMB; 27 samples, the Central Granulite Terrane (CGT; Adirondack's; 13 samples and the Ottawan Orogenic Lid (OOL; 11 samples. Twinning strains in the greenschist-grade OOL marbles preserve N–S shortening and U-Pb titanite ages (∼1150 Ma; n = 4 document these marbles formed during the Shawinigan (1190–1140 Ma part of the Grenville orogen. From northwest to southeast, the Ottawan (1095–1020 Ma twinning strain is dominantly a layer-parallel shortening fabric oriented N–S (Parry Sound, then becomes parallel to the Grenville thrust direction (NW–SE across the CMB to the Adirondack Highlands where the sub-horizontal shortening strain becomes margin-parallel (SW–NE. Within the regional sample suite there are two areas studied in detail, the Bancroft shear zone (n = 11 and a roadcut on the southeast side of the Adirondack Mountains (Ft. Ann, NY; n = 8. Marbles from the Bancroft shear zone contain calcite grains with 2 sets of twin lamellae (e1 and e2. The better-developed e1 sets (n = 406 record a horizontal fabric oriented NW–SE whereas the younger e2 lamellae (n = 146 preserve a margin-parallel (SW–NE horizontal fabric. Both the e1 and e2 strains record an overprint vertical shortening strain (NEV, perhaps related to extensional orogenic collapse. We also report an Ottawan orogen-aged granoblastic mylonite (1093 Ma, U-Pb zircon; 1102 Ma Ar-Ar biotite in the Keweenaw thrust hanging wall 500 km inboard of the Grenville front and interpret the relations of Grenville

  18. Nanoscale Dewetting Transition in Protein Complex Folding (United States)

    Hua, Lan; Huang, Xuhui; Liu, Pu; Zhou, Ruhong; Berne, Bruce J.


    In a previous study, a surprising drying transition was observed to take place inside the nanoscale hydrophobic channel in the tetramer of the protein melittin. The goal of this paper is to determine if there are other protein complexes capable of displaying a dewetting transition during their final stage of folding. We searched the entire protein data bank (PDB) for all possible candidates, including protein tetramers, dimers, and two-domain proteins, and then performed the molecular dynamics (MD) simulations on the top candidates identified by a simple hydrophobic scoring function based on aligned hydrophobic surface areas. Our large scale MD simulations found several more proteins, including three tetramers, six dimers, and two two-domain proteins, which display a nanoscale dewetting transition in their final stage of folding. Even though the scoring function alone is not sufficient (i.e., a high score is necessary but not sufficient) in identifying the dewetting candidates, it does provide useful insights into the features of complex interfaces needed for dewetting. All top candidates have two features in common: (1) large aligned (matched) hydrophobic areas between two corresponding surfaces, and (2) large connected hydrophobic areas on the same surface. We have also studied the effect on dewetting of different water models and different treatments of the long-range electrostatic interactions (cutoff vs PME), and found the dewetting phenomena is fairly robust. This work presents a few proteins other than melittin tetramer for further experimental studies of the role of dewetting in the end stages of protein folding. PMID:17608515

  19. Incremental fold tests of remagnetized carbonate rocks (United States)

    Van Der Voo, R.; van der Pluijm, B.


    Many unmetamorphosed carbonates all over the world are demonstrably remagnetized, with the age of the secondary magnetizations typically close to that of the nearest orogeny in space and time. This observation did not become compelling until the mid-1980's, when the incremental fold test revealed the Appalachian carbonates to carry a syn-deformational remanence of likely Permian age (Scotese et al., 1982, Phys. Earth Planet. Int., v. 30, p. 385-395; Cederquist et al., 2006, Tectonophysics v. 422, p. 41-54). Since that time scores of Appalachian and Rocky Mountain carbonate rocks have added results to the growing database of paleopoles representing remagnetizations. Late Paleozoic remagnetizations form a cloud of results surrounding the reference poles of the Laurentian APWP. Remagnetizations in other locales and with inferred ages coeval with regional orogenies (e.g., Taconic, Sevier/Laramide, Variscan, Indosinian) are also ubiquitous. To be able to transform this cornucopia into valuable anchor-points on the APWP would be highly desirable. This may indeed become feasible, as will be explained next. Recent studies of faulted and folded carbonate-shale sequences have shown that this deformation enhances the illitization of smectite (Haines & van der Pluijm, 2008, Jour. Struct. Geol., v. 30, p. 525-538; Fitz-Diaz et al., 2014, International Geol. Review, v. 56, p. 734-755). 39Ar-40Ar dating of the authigenic illite (neutralizing any detrital illite contribution by taking the intercept of a mixing line) yields, therefore, the age of the deformation. We know that this date is also the age of the syndeformational remanence; thus we have the age of the corresponding paleopole. Results so far are obtained for the Canadian and U.S. Rocky Mountains and for the Spanish Cantabrian carbonates (Tohver et al., 2008, Earth Planet. Sci. Lett., v. 274, p. 524-530) and make good sense in accord with geological knowledge. Incremental fold tests are the tools used for this

  20. Synovial folds in the knee joint

    International Nuclear Information System (INIS)

    Schaefer, H.


    Stimulated by arthroscopic insight into central abnormalities of the knee joint and by the large number of unexplained case of 'anterior knee pain', we have studied the synovia in more than 2000 contrast examinations of the joint. Surprisingly, and contrary to the views expressed in the literature, the clinically significant plica parapatellaris medialis was seen as frequently during pneumo-arthrography as during more complex procedures. Abnormalities in the synovial fold emerged as a discreet disease identified as the 'medial shelf syndrome' and should be included in the differential diagnosis of causes of pain round the lower end of the femur and patella. (orig.) [de

  1. Evidence of orbital forcing in lake-level fluctuations in the Middle Eocene oil shale-bearing lacustrine successions in the Mudurnu-Göynük Basin, NW Anatolia (Turkey) (United States)

    Ocakoğlu, F.; Açıkalın, S.; Yılmaz, İ. Ö.; Şafak, Ü.; Gökçeoğlu, C.


    Mudurnu-Göynük basin of the Sakarya Zone in NW Anatolia comprises ca. 1500 m thick Paleocene-Eocene terrestrial to shallow marine succession overlying the Late Cretaceous deeper marine progradational fore-arc sediments. Formed in a foreland setting in relation to southerly situated İzmir-Ankara suture zone, this terrestrial succession (regionally known as Kızılçay group) comprises a thin (nalysis on three correlative measured sections showed that mudstone, oil shale and thinner limestone alternations characterize the relatively deeper part of the Eocene lake with probable marine intervention, while thicker limestone, coal, marl and occasional oil shale alternations typify the southern relatively freshwater shoal areas. These facies are frequently organized as meter-scale symmetric to asymmetric transgressive-regressive cycles. Spectral analysis of the mudstone beds and the cycles within the lacustrine succession strongly indicates the occurrence of full bands of Milankovitch with the shortest precession cycle (19 ka) at ca. 2.30 m. Our observations further revealed quite rhythmic thin couplets with estimated durations of 365-730 yr that might represent abrupt climatic changes during deposition. On the other hand, longer duration (ca. 1 Ma) of shoaling and deepening trends in the studied sections were attributed basically to varying subsidence due to tectonic loading in the southerly suture zone. Lastly, regarding the distribution of depositional environments we propose that the oil shale exploration activities should be carried out within a 20 km wide E-W running belt while the southern limits of this belt is more prolific for coal resources.


    Energy Technology Data Exchange (ETDEWEB)

    Hodapp, Klaus W. [Institute for Astronomy, University of Hawaii, 640 N. Aohoku Place, Hilo, HI 96720 (United States); Chini, Rolf; Watermann, Ramon; Lemke, Roland, E-mail: [Ruhr Universitaet Bochum, Astronomisches Institut, Universitaetsstrasse 150, D-44801 Bochum (Germany)


    We study the outflow activity, photometric variability, and morphology of three very young stellar objects in the Serpens NW star-forming region: OO Serpentis, EC 37 (V370 Ser), and EC 53 (V371 Ser). High spatial resolution Keck/NIRC2 laser guide star adaptive optics images obtained in 2007 and 2009 in broadband K and in a narrowband filter centered on the 1-0 S(1) emission line of H{sub 2} allow us to identify the outflows from all three objects. We also present new, seeing-limited data on the photometric evolution of the OO Ser reflection nebula and re-analyze previously published data. We find that OO Ser declined in brightness from its outburst peak in 1995 to about 2003, but that this decline has recently stopped and actually reversed itself in some areas of the reflection nebula. The morphology and proper motions of the shock fronts MHO 2218 near EC 37 suggest that they all originate in EC 37 and that this is an outflow seen nearly along its axis. We identify an H{sub 2} jet emerging from the cometary nebula EC 53. The star illuminating EC 53 is periodically variable with a period of 543 days and has a close-by, non-variable companion at a projected distance of 92 AU. We argue that the periodic variability is the result of accretion instabilities triggered by another very close, not directly observable, binary companion and that EC 53 can be understood in the model of a multiple system developing into a hierarchical configuration.

  3. Timing and Spatial Distribution of Loess in Xinjiang, NW China.

    Directory of Open Access Journals (Sweden)

    Yun Li

    Full Text Available Central Asia is one of the most significant loess regions on Earth, with an important role in understanding Quaternary climate and environmental change. However, in contrast to the widely investigated loess deposits in the Chinese Loess Plateau, the Central Asian loess-paleosol sequences are still insufficiently known and poorly understood. Through field investigation and review of the previous literature, the authors have investigated the distribution, thickness and age of the Xinjiang loess, and analyzed factors that control these parameters in the Xinjiang in northwest China, Central Asia. The loess sediments cover river terraces, low uplands, the margins of deserts and the slopes of the Tianshan Mountains and Kunlun Mountains and are also present in the Ili Basin. The thickness of the Xinjiang loess deposits varies from several meters to 670 m. The variation trend of the sand fraction (>63 μm grain-size contour can indicate the local major wind directions, so we conclude that the NW and NE winds are the main wind directions in the North and South Xinjiang, and the westerly wind mainly transport dust into the Ili basin. We consider persistent drying, adequate regional wind energy and well-developed river terraces to be the main factors controlling the distribution, thickness and formation age of the Xinjiang loess. The well-outcropped loess sections have mainly developed since the middle Pleistocene in Xinjiang, reflecting the appearance of the persistent drying and the present air circulation system. However, the oldest loess deposits are as old as the beginning of the Pliocene in the Tarim Basin, which suggests that earlier aridification occurred in the Tarim Basin rather than in the Ili Basin and the Junggar Basin.

  4. Firewood Resource Management in Different Landscapes in NW Patagonia

    Directory of Open Access Journals (Sweden)

    Daniela V. Morales


    Full Text Available Ecosystems, their components, processes and functions are all subject to management by human populations, with the purpose of adapting the environments to make them more habitable and ensuring the availability and continuity of subsistence resources. Although a lot of work has been carried out on resources of alimentary or medicinal interest, little has been done on associating processes of domestication with firewood extraction, a practice considered to be destructive of the environment. In the arid steppe of NW Patagonia, inhabited and managed for different purposes for a long time by Mapuche-Tehuelche communities, the gathering of combustible plant species has up to the present time played a crucial role in cooking and heating, and work is required to achieve sustainability of this resource. In this study we evaluate whether environments with less landscape domestication are more intensively used for firewood gathering. Using an ethnobiological approach, information was obtained through participant observation, interviews and free listing. The data were examined using both qualitative and quantitative approaches. Twenty-eight firewood species are gathered, both native (75% and exotic (25%. The supply of firewood mainly depends on gathering from the domesticated (10 species, semi-domesticated (17 species and low human intervention landscapes (17 species. In contrast to our hypothesis, average use intensity is similar in all these landscapes despite their different levels of domestication. That is, the different areas are taken advantage of in a complementary manner in order to satisfy the domestic demand for firewood. Neither do biogeographic origin or utilitarian versatility of collected plants vary significantly between the different landscape levels of domestication. Our results show that human landscape domestication for the provision of firewood seems to be a socio-cultural resilient practice, and shed new light on the role of culture in

  5. Folding model analysis of alpha radioactivity

    International Nuclear Information System (INIS)

    Basu, D N


    Radioactive decay of nuclei via emission of α-particles has been studied theoretically in the framework of a superasymmetric fission model using the double folding (DF) procedure for obtaining the α-nucleus interaction potential. The DF nuclear potential has been obtained by folding in the density distribution functions of the α nucleus and the daughter nucleus with a realistic effective interaction. The M3Y effective interaction has been used for calculating the nuclear interaction potential which has been supplemented by a zero-range pseudo-potential for exchange along with the density dependence. The nuclear microscopic α-nucleus potential thus obtained has been used along with the Coulomb interaction potential to calculate the action integral within the WKB approximation. This subsequently yields calculations for the half-lives of α decays of nuclei. The density dependence and the exchange effects have not been found to be very significant. These calculations provide reasonable estimates for the lifetimes of α-radioactivity of nuclei

  6. Balancing cross-sections combining field work and remote sensing data using LithoTect software in the Zagros fold-and-thrust belt, N Iraq. (United States)

    Reif, Daniel; Grasemann, Bernhard; Lockhart, Duncan


    The Zagros fold-and-thrust belt has formed in detached Phanerozoic sedimentary cover rocks above a shortened crystalline Precambrian basement and evolved through the Late Cretaceous to Miocene collision between the Arabian and Eurasian plate, during which the Neotethys oceanic basin was closed. Deformation is partitioned in SW directed folding and thrusting of the sediments and NW-SE to N-S trending dextral strike slip faults. The sub-cylindrical doubly-plunging fold trains with wavelengths of 5 - 10 km host more than half of the world's hydrocarbon reserves in mostly anticlinal traps. Generally the Zagros is divided into three NW-SE striking tectonic units: the Zagros Imbricate Zone, the Zagros Simply Folded Belt and the Zagros Foredeep. This work presents a balanced cross-section through the Simply Folded Belt, NE of the city of Erbil (Kurdistan, Iraq). The regional stratigraphy comprises mainly Cretaceous to Cenozoic folded sediments consisting of massive, carbonate rocks (limestones, dolomites), reacting as competent layers during folding compared to the incompetent behavior of interlayered siltstones, claystones and marls. Although the overall security situation in Kurdistan is much better than in the rest of Iraq, structural field mapping was restricted to asphalt streets, mainly because of the contamination of the area with landmines and unexploded ordnance. In order to extend the structural measurements statistically over the investigated area, we used a newly developed software tool ( for interactive structural mapping of spatial orientations (i.e. dip direction and dip angles) of the sedimentary beddings from digital elevation models. Structural field data and computed measurements where integrated and projected in NE-SW striking balanced cross-sections perpendicular to the regional trend of the fold axes. We used the software LithoTect ( for the restoration of the cross-sections. Depending on the interpretation

  7. Seismic interpretation of the triangle zone at Jumping Pound, Alberta

    Energy Technology Data Exchange (ETDEWEB)

    Slotboom, R. T. [Amerada Hess Canada Ltd., Calgary, AB (Canada); Lawton, D. C.; Spratt, D. A. [Calgary Univ., AB (Canada). Dept. of Geology and Geophysics


    The triangle zone at Jumping Point, Alberta was characterized using seismic survey data as a NW-SE-trending antiformal stack of thrust sheets involving Cretaceous rocks that have been wedged into the foreland between two detachments. Three major thrust sheets of Lower and Upper Cretaceous strata have been stacked to form the main extremity of the wedge. The structure is tightly folded at Jumping Point, and broadens northwest along the strike. 13 refs., 8 figs.

  8. Structural analysis of the Hasan-Robat marbles as traces of folded basement in the Sanandaj-Sirjan Zone, Iran (United States)

    Nadimi, Alireza


    Cherty marbles of Hasan-Robat area, northwest of Isfahan, in the Sanandaj-Sirjan Zone of Iran preserves evidences of multiple deformational events. The Sanandaj-Sirjan Zone is the inner crystalline zone of the Zagros Orogen, which has been highly deformed and exhumed during continental collision between the Arabian Plate and Central Iran. The Hasan-Robat area is an example of the exposed Precambrian-Paleozoic basement rocks that stretched along two NW-SE-trending faults and located in the inner part of the HasanRobat positive flower strcuture. The Hasan-Robat marbles record a complex shortening and shearing history. This lead to the development of disharmonic ptygmatic folds with vertical to sub-vertical axes and some interference patterns of folding that may have been created from deformations during the Pan-African Orogeny and later phases. Based on this research, tectonic evolution of the Hasan-Robat area is interpreted as the product of three major geotectonic events that have been started after Precambrian to Quaternary: (1) old deformation phases (2) contractional movements and (3) strike-slip movements. Different sets and distributions of joints, faults and folds are confirmed with effect of several deformational stages of the area and formation of the flower structure.

  9. SVM-Fold: a tool for discriminative multi-class protein fold and superfamily recognition. (United States)

    Melvin, Iain; Ie, Eugene; Kuang, Rui; Weston, Jason; Stafford, William Noble; Leslie, Christina


    Predicting a protein's structural class from its amino acid sequence is a fundamental problem in computational biology. Much recent work has focused on developing new representations for protein sequences, called string kernels, for use with support vector machine (SVM) classifiers. However, while some of these approaches exhibit state-of-the-art performance at the binary protein classification problem, i.e. discriminating between a particular protein class and all other classes, few of these studies have addressed the real problem of multi-class superfamily or fold recognition. Moreover, there are only limited software tools and systems for SVM-based protein classification available to the bioinformatics community. We present a new multi-class SVM-based protein fold and superfamily recognition system and web server called SVM-Fold, which can be found at Our system uses an efficient implementation of a state-of-the-art string kernel for sequence profiles, called the profile kernel, where the underlying feature representation is a histogram of inexact matching k-mer frequencies. We also employ a novel machine learning approach to solve the difficult multi-class problem of classifying a sequence of amino acids into one of many known protein structural classes. Binary one-vs-the-rest SVM classifiers that are trained to recognize individual structural classes yield prediction scores that are not comparable, so that standard "one-vs-all" classification fails to perform well. Moreover, SVMs for classes at different levels of the protein structural hierarchy may make useful predictions, but one-vs-all does not try to combine these multiple predictions. To deal with these problems, our method learns relative weights between one-vs-the-rest classifiers and encodes information about the protein structural hierarchy for multi-class prediction. In large-scale benchmark results based on the SCOP database, our code weighting approach

  10. Modeling and Inversion of three-dimensional crustal structures beneath the Pyrenees and their foreland basins based upon geological, gravimetric and seismological data (United States)

    Spangenberg, Hannah; Chevrot, Sébastien; Courrioux, Gabriel; Guillen, Antonio


    Our goal is to obtain a three-dimensional (3D) model of mass density and seismic velocities beneath the Pyrenees and their foreland basins (Aquitaine and Ebro basins), which accounts for all the geological and geophysical information available for that region. This model covers the whole mountain range going from the Atlantic Ocean to the Mediterranean Sea, and from the Iberian range to the Massif Central. The model is described by different units: the lower, middle, and upper crusts, the accretionary prism, and the consolidated and unconsolidated sediment layers. Furthermore, a sub-continental, serpentinized European mantle is introduced to describe the exhumed mantle bodies which are responsible for the positive Bouguer gravity anomalies in the western Pyrenees. We build a first 3D model using all the geological information: drill-hole surveys, seismic sections, and the geological map. We use the potential field method implemented in Geomodeler to interpolate these geological data. However, these data are too sparse to build a model that explains seismic travel times or gravimetric data, especially the Labourd and the St. Gaudens Bouguer gravity anomalies. In addition, inconsistencies between the different data sets exist. We thus add by trial and error additional data points, comparing modeled and observed Bouguer gravimetric anomalies. The result of this procedure is a 3D geological model that respects the geological data and explains the measured Bouguer gravimetric anomalies. In a second step, we use this model to determine the average density and seismic velocities inside each geological unit assuming uniform layers. To constrain the seismic velocities we use travel time picks extracted from the bulletin of the Pyrenean seismicity released by the Observatoire Midi Pyrenées. In a third step, we use this 3D a priori model in a Monte Carlo inversion to invert jointly gravimetric data and seismic travel times from the bulletin. This probabilistic approach

  11. The lithospheric-scale 3D structural configuration of the North Alpine Foreland Basin constrained by gravity modelling and the calculation of the 3D load distribution (United States)

    Przybycin, Anna M.; Scheck-Wenderoth, Magdalena; Schneider, Michael


    The North Alpine Foreland Basin is situated in the northern front of the European Alps and extends over parts of France, Switzerland, Germany and Austria. It formed as a wedge shaped depression since the Tertiary in consequence of the Euro - Adriatic continental collision and the Alpine orogeny. The basin is filled with clastic sediments, the Molasse, originating from erosional processes of the Alps and underlain by Mesozoic sedimentary successions and a Paleozoic crystalline crust. For our study we have focused on the German part of the basin. To investigate the deep structure, the isostatic state and the load distribution of this region we have constructed a 3D structural model of the basin and the Alpine area using available depth and thickness maps, regional scale 3D structural models as well as seismic and well data for the sedimentary part. The crust (from the top Paleozoic down to the Moho (Grad et al. 2008)) has been considered as two-parted with a lighter upper crust and a denser lower crust; the partition has been calculated following the approach of isostatic equilibrium of Pratt (1855). By implementing a seismic Lithosphere-Asthenosphere-Boundary (LAB) (Tesauro 2009) the crustal scale model has been extended to the lithospheric-scale. The layer geometry and the assigned bulk densities of this starting model have been constrained by means of 3D gravity modelling (BGI, 2012). Afterwards the 3D load distribution has been calculated using a 3D finite element method. Our results show that the North Alpine Foreland Basin is not isostatically balanced and that the configuration of the crystalline crust strongly controls the gravity field in this area. Furthermore, our results show that the basin area is influenced by varying lateral load differences down to a depth of more than 150 km what allows a first order statement of the required compensating horizontal stress needed to prevent gravitational collapse of the system. BGI (2012). The International

  12. Dysphonia and vocal fold telangiectasia in hereditary hemorrhagic telangiectasia. (United States)

    Chang, Joseph; Yung, Katherine C


    This case report is the first documentation of dysphonia and vocal fold telangiectasia as a complication of hereditary hemorrhagic telangiectasia (HHT). Case report of a 40-year-old man with HHT presenting with 2 years of worsening hoarseness. Hoarseness corresponded with a period of anticoagulation. Endoscopy revealed vocal fold scarring, vocal fold telangiectasias, and plica ventricular is suggestive of previous submucosal vocal fold hemorrhage and subsequent counterproductive compensation with ventricular phonation. Hereditary hemorrhagic telangiectasia may present as dysphonia with vocal fold telangiectasias and place patients at risk of vocal fold hemorrhage. © The Author(s) 2014.

  13. Improving decoy databases for protein folding algorithms

    KAUST Repository

    Lindsey, Aaron


    Copyright © 2014 ACM. Predicting protein structures and simulating protein folding are two of the most important problems in computational biology today. Simulation methods rely on a scoring function to distinguish the native structure (the most energetically stable) from non-native structures. Decoy databases are collections of non-native structures used to test and verify these functions. We present a method to evaluate and improve the quality of decoy databases by adding novel structures and removing redundant structures. We test our approach on 17 different decoy databases of varying size and type and show significant improvement across a variety of metrics. We also test our improved databases on a popular modern scoring function and show that they contain a greater number of native-like structures than the original databases, thereby producing a more rigorous database for testing scoring functions.

  14. Folded tandem ion accelerator facility at BARC

    International Nuclear Information System (INIS)

    Agarwal, Arun; Padmakumar, Sapna; Subrahmanyam, N.B.V.; Singh, V.P.; Bhatt, J.P.; Ware, Shailaja V.; Pol, S.S; Basu, A.; Singh, S.K.; Krishnagopal, S.; Bhagwat, P.V.


    The 5.5 MV single stage Van de Graaff (VDG) accelerator was in continuous operation at Nuclear Physics Division (NPD), Bhabha Atomic Research Centre (BARC) since its inception in 1962. During 1993-96, VDG accelerator was converted to a Folded Tandem Ion Accelerator (FOTIA). The scientists and engineers of NPD, IADD (then a part of NPD) along with several other divisions of BARC joined hands together in designing, fabrication, installation and commissioning of the FOTIA for the maximum terminal voltage of 6 MV. After experiencing the first accelerated ion beam on the target from FOTIA during April 2000, different ion species were accelerated and tested. Now this accelerator FOTIA is in continuous use for different kind of experiments

  15. Electrotransfection of Polyamine Folded DNA Origami Structures. (United States)

    Chopra, Aradhana; Krishnan, Swati; Simmel, Friedrich C


    DNA origami structures are artificial molecular nanostructures in which DNA double helices are forced into a closely packed configuration by a multitude of DNA strand crossovers. We show that three different types of origami structures (a flat sheet, a hollow tube, and a compact origami block) can be formed in magnesium-free buffer solutions containing low (origami folding is proportional to the DNA concentration. At excessive amounts, the structures aggregate and precipitate. In contrast to origami structures formed in conventional buffers, the resulting structures are stable in the presence of high electric field pulses, such as those commonly used for electrotransfection experiments. We demonstrate that spermidine-stabilized structures are stable in cell lysate and can be delivered into mammalian cells via electroporation.

  16. Some physical approaches to protein folding (United States)

    Bascle, J.; Garel, T.; Orland, H.


    To understand how a protein folds is a problem which has important biological implications. In this article, we would like to present a physics-oriented point of view, which is twofold. First of all, we introduce simple statistical mechanics models which display, in the thermodynamic limit, folding and related transitions. These models can be divided into (i) crude spin glass-like models (with their Mattis analogs), where one may look for possible correlations between the chain self-interactions and the folded structure, (ii) glass-like models, where one emphasizes the geometrical competition between one- or two-dimensional local order (mimicking α helix or β sheet structures), and the requirement of global compactness. Both models are too simple to predict the spatial organization of a realistic protein, but are useful for the physicist and should have some feedback in other glassy systems (glasses, collapsed polymers .... ). These remarks lead us to the second physical approach, namely a new Monte-Carlo method, where one grows the protein atom-by-atom (or residue-by-residue), using a standard form (CHARMM .... ) for the total energy. A detailed comparison with other Monte-Carlo schemes, or Molecular Dynamics calculations, is then possible; we will sketch such a comparison for poly-alanines. Our twofold approach illustrates some of the difficulties one encounters in the protein folding problem, in particular those associated with the existence of a large number of metastable states. Le repliement des protéines est un problème qui a de nombreuses implications biologiques. Dans cet article, nous présentons, de deux façons différentes, un point de vue de physicien. Nous introduisons tout d'abord des modèles simples de mécanique statistique qui exhibent, à la limite thermodynamique, des transitions de repliement. Ces modèles peuvent être divisés en (i) verres de spin (éventuellement à la Mattis), où l'on peut chercher des corrélations entre les

  17. Description of some characteristics of flowers and seeds of Arabidopsis thaliana - ecotype landsberg erecta and mutant NW4

    Directory of Open Access Journals (Sweden)

    Leszek Trząski


    Full Text Available Flowers and seeds of Landsberg erecta (Ler ecotype and NW4 mutant were studied by light microscopy and scanning electron microscopy to reveal characteristic features of their structure. The NW4 mutant flowers differ from Ler mainly in presence of two bract-like sepals with complicated vasculature and a variable number of secondary flowers. In the two outer whorls of NW4 flower, variable number of transformed stamen-, petal-, sepal- and style-like elements also occur. The NW4 mutant seeds are characterized by the absence of mucilage around the surface and a deviating seed coat morphology.

  18. How the structural architecture of the Eurasian continental margin affects the structure, seismicity, and topography of the south central Taiwan fold-and-thrust belt (United States)

    Brown, Dennis; Alvarez-Marron, Joaquina; Biete, Cristina; Kuo-Chen, Hao; Camanni, Giovanni; Ho, Chun-Wei


    Studies of mountain belts worldwide show that along-strike changes are common in their foreland fold-and-thrust belts. These are typically caused by processes related to fault reactivation and/or fault focusing along changes in sedimentary sequences. The study of active orogens, like Taiwan, can also provide insights into how these processes influence transient features such as seismicity and topography. In this paper, we trace regional-scale features from the Eurasian continental margin in the Taiwan Strait into the south central Taiwan fold-and-thrust belt. We then present newly mapped surface geology, P wave velocity maps and sections, seismicity, and topography data to test the hypothesis of whether or not these regional-scale features of the margin are contributing to along-strike changes in structural style, and the distribution of seismicity and topography in this part of the Taiwan fold-and-thrust belt. These data show that the most important along-strike change takes place at the eastward prolongation of the upper part of the margin necking zone, where there is a causal link between fault reactivation, involvement of basement in the thrusting, concentration of seismicity, and the formation of high topography. On the area correlated with the necking zone, the strike-slip reactivation of east northeast striking extensional faults is causing sigmoidal offset of structures and topography along two main zones. Here basement is not involved in the thrusting; there is weak focusing of seismicity and localized development of topography. We also show that there are important differences in structure, seismicity, and topography between the margin shelf and its necking zone.

  19. The Padul normal fault activity constrained by GPS data: Brittle extension orthogonal to folding in the central Betic Cordillera (United States)

    Gil, Antonio J.; Galindo-Zaldívar, Jesús; Sanz de Galdeano, Carlos; Borque, Maria Jesús; Sánchez-Alzola, Alberto; Martinez-Martos, Manuel; Alfaro, Pedro


    The Padul Fault is located in the Central Betic Cordillera, formed in the framework of the NW-SE Eurasian-African plate convergence. In the Internal Zone, large E-W to NE-SW folds of western Sierra Nevada accommodated the greatest NW-SE shortening and uplift of the cordillera. However, GPS networks reveal a present-day dominant E-W to NE-SW extensional setting at surface. The Padul Fault is the most relevant and best exposed active normal fault that accommodates most of the NE-SW extension of the Central Betics. This WSW-wards dipping fault, formed by several segments of up to 7 km maximum length, favored the uplift of the Sierra Nevada footwall away from the Padul graben hanging wall. A non-permanent GPS network installed in 1999 constrains an average horizontal extensional rate of 0.5 mm/yr in N66°E direction. The fault length suggests that a (maximum) 6 magnitude earthquake may be expected, but the absence of instrumental or historical seismic events would indicate that fault activity occurs at least partially by creep. Striae on fault surfaces evidence normal-sinistral kinematics, suggesting that the Padul Fault may have been a main transfer fault of the westernmost end of the Sierra Nevada antiform. Nevertheless, GPS results evidence: (1) shortening in the Sierra Nevada antiform is in its latest stages, and (2) the present-day fault shows normal with minor oblique dextral displacements. The recent change in Padul fault kinematics will be related to the present-day dominance of the ENE-WSW regional extension versus NNW-SSE shortening that produced the uplift and northwestwards displacement of Sierra Nevada antiform. This region illustrates the importance of heterogeneous brittle extensional tectonics in the latest uplift stages of compressional orogens, as well as the interaction of folding during the development of faults at shallow crustal levels.

  20. The review on tessellation origami inspired folded structure (United States)

    Chu, Chai Chen; Keong, Choong Kok


    Existence of folds enhances the load carrying capacity of a folded structure which makes it suitable to be used for application where large open space is required such as large span roof structures and façade. Folded structure is closely related to origami especially the tessellation origami. Tessellation origami provides a folded configuration with facetted surface as a result from repeated folding pattern. Besides that, tessellation origami has flexible folding mechanism that produced a variety of 3-dimensional folded configurations. Despite the direct relationship between fold in origami and folded structure, the idea of origami inspired folded structure is not properly reviewed in the relevant engineering field. Hence, this paper aims to present the current studies from related discipline which has direct relation with application of tessellation origami in folded structure. First, tessellation origami is properly introduced and defined. Then, the review covers the topic on the origami tessellation design suitable for folded structure, its modeling and simulation method, and existing studies and applications of origami as folded structure is presented. The paper also includes the discussion on the current issues related to each topic.

  1. Improving Protein Fold Recognition by Deep Learning Networks (United States)

    Jo, Taeho; Hou, Jie; Eickholt, Jesse; Cheng, Jianlin


    For accurate recognition of protein folds, a deep learning network method (DN-Fold) was developed to predict if a given query-template protein pair belongs to the same structural fold. The input used stemmed from the protein sequence and structural features extracted from the protein pair. We evaluated the performance of DN-Fold along with 18 different methods on Lindahl’s benchmark dataset and on a large benchmark set extracted from SCOP 1.75 consisting of about one million protein pairs, at three different levels of fold recognition (i.e., protein family, superfamily, and fold) depending on the evolutionary distance between protein sequences. The correct recognition rate of ensembled DN-Fold for Top 1 predictions is 84.5%, 61.5%, and 33.6% and for Top 5 is 91.2%, 76.5%, and 60.7% at family, superfamily, and fold levels, respectively. We also evaluated the performance of single DN-Fold (DN-FoldS), which showed the comparable results at the level of family and superfamily, compared to ensemble DN-Fold. Finally, we extended the binary classification problem of fold recognition to real-value regression task, which also show a promising performance. DN-Fold is freely available through a web server at

  2. Improving Protein Fold Recognition by Deep Learning Networks. (United States)

    Jo, Taeho; Hou, Jie; Eickholt, Jesse; Cheng, Jianlin


    For accurate recognition of protein folds, a deep learning network method (DN-Fold) was developed to predict if a given query-template protein pair belongs to the same structural fold. The input used stemmed from the protein sequence and structural features extracted from the protein pair. We evaluated the performance of DN-Fold along with 18 different methods on Lindahl's benchmark dataset and on a large benchmark set extracted from SCOP 1.75 consisting of about one million protein pairs, at three different levels of fold recognition (i.e., protein family, superfamily, and fold) depending on the evolutionary distance between protein sequences. The correct recognition rate of ensembled DN-Fold for Top 1 predictions is 84.5%, 61.5%, and 33.6% and for Top 5 is 91.2%, 76.5%, and 60.7% at family, superfamily, and fold levels, respectively. We also evaluated the performance of single DN-Fold (DN-FoldS), which showed the comparable results at the level of family and superfamily, compared to ensemble DN-Fold. Finally, we extended the binary classification problem of fold recognition to real-value regression task, which also show a promising performance. DN-Fold is freely available through a web server at

  3. An Operational Coastal Forecasting System in Galicia (NW Spain) (United States)

    Balseiro, C. F.; Carracedo, P.; Pérez, E.; Pérez, V.; Taboada, J.; Venacio, A.; Vilasa, L.


    The Galician coast (NW Iberian Peninsula coast) and mainly the Rias Baixas (southern Galician rias) are one of the most productive ecosystems in the world, supporting a very active fishing and aquiculture industry. This high productivity lives together with a high human pressure and an intense maritime traffic, which means an important environmental risk. Besides that, Harmful Algae Blooms (HAB) are common in this area, producing important economical losses in aquiculture. In this context, the development of an Operational Hydrodynamic Ocean Forecast System is the first step to the development of a more sophisticated Ocean Integrated Decision Support Tool. A regional oceanographic forecasting system in the Galician Coast has been developed by MeteoGalicia (the Galician regional meteorological agency) inside ESEOO project to provide forecasts on currents, sea level, water temperature and salinity. This system is based on hydrodynamic model MOHID, forced with the operational meteorological model WRF, supported daily at MeteoGalicia . Two grid meshes are running nested at different scales, one of ~2km at the shelf scale and the other one with a resolution of 500 m at the rias scale. ESEOAT (Puertos del Estado) model provide salinity and temperature fields which are relaxed at all depth along the open boundary of the regional model (~6km). Temperature and salinity initial fields are also obtained from this application. Freshwater input from main rivers are included as forcing in MOHID model. Monthly mean discharge data from gauge station have been provided by Aguas de Galicia. Nowadays a coupling between an hydrological model (SWAT) and the hydrodynamic one are in development with the aim to verify the impact of the rivers discharges. The system runs operationally daily, providing two days of forecast. First model verifications had been performed against Puertos del Estado buoys and Xunta de Galicia buoys network along the Galician coast. High resolution model results

  4. RNAiFold: a web server for RNA inverse folding and molecular design. (United States)

    Garcia-Martin, Juan Antonio; Clote, Peter; Dotu, Ivan


    Synthetic biology and nanotechnology are poised to make revolutionary contributions to the 21st century. In this article, we describe a new web server to support in silico RNA molecular design. Given an input target RNA secondary structure, together with optional constraints, such as requiring GC-content to lie within a certain range, requiring the number of strong (GC), weak (AU) and wobble (GU) base pairs to lie in a certain range, the RNAiFold web server determines one or more RNA sequences, whose minimum free-energy secondary structure is the target structure. RNAiFold provides access to two servers: RNA-CPdesign, which applies constraint programming, and RNA-LNSdesign, which applies the large neighborhood search heuristic; hence, it is suitable for larger input structures. Both servers can also solve the RNA inverse hybridization problem, i.e. given a representation of the desired hybridization structure, RNAiFold returns two sequences, whose minimum free-energy hybridization is the input target structure. The web server is publicly accessible at, which provides access to two specialized servers: RNA-CPdesign and RNA-LNSdesign. Source code for the underlying algorithms, implemented in COMET and supported on linux, can be downloaded at the server website.

  5. Glycoprotein folding and quality-control mechanisms in protein-folding diseases

    Directory of Open Access Journals (Sweden)

    Sean P. Ferris


    Full Text Available Biosynthesis of proteins – from translation to folding to export – encompasses a complex set of events that are exquisitely regulated and scrutinized to ensure the functional quality of the end products. Cells have evolved to capitalize on multiple post-translational modifications in addition to primary structure to indicate the folding status of nascent polypeptides to the chaperones and other proteins that assist in their folding and export. These modifications can also, in the case of irreversibly misfolded candidates, signal the need for dislocation and degradation. The current Review focuses on the glycoprotein quality-control (GQC system that utilizes protein N-glycosylation and N-glycan trimming to direct nascent glycopolypeptides through the folding, export and dislocation pathways in the endoplasmic reticulum (ER. A diverse set of pathological conditions rooted in defective as well as over-vigilant ER quality-control systems have been identified, underlining its importance in human health and disease. We describe the GQC pathways and highlight disease and animal models that have been instrumental in clarifying our current understanding of these processes.

  6. Effect of Vocal Fold Medialization on Dysphagia in Patients with Unilateral Vocal Fold Immobility. (United States)

    Cates, Daniel J; Venkatesan, Naren N; Strong, Brandon; Kuhn, Maggie A; Belafsky, Peter C


    The effect of vocal fold medialization (VFM) on vocal improvement in persons with unilateral vocal fold immobility (UVFI) is well established. The effect of VFM on the symptom of dysphagia is uncertain. The purpose of this study is to evaluate dysphagia symptoms in patients with UVFI pre- and post-VFM. Case series with chart review. Academic tertiary care medical center. The charts of 44 persons with UVFI who underwent VFM between June 1, 2013, and December 31, 2014, were abstracted from a prospectively maintained database at the University of California, Davis, Voice and Swallowing Center. Patient demographics, indications, and type of surgical procedure were recorded. Self-reported swallowing impairment was assessed with the validated 10-item Eating Assessment Tool (EAT-10) before and after surgery. A paired samples t test was used to compare pre- and postmedialization EAT-10 scores. Forty-four patients met criteria and underwent either vocal fold injection (73%) or thyroplasty (27%). Etiologies of vocal fold paralysis were iatrogenic (55%), idiopathic (29%), benign or malignant neoplastic (9%), traumatic (5%), or related to the late effects of radiation (2%). EAT-10 (mean ± SD) scores improved from 12.2 ± 11.1 to 7.7 ± 7.2 after medialization (P dysphagia and report significant improvement in swallowing symptoms following VFM. The symptomatic improvement appears to be durable over time. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016.

  7. Self-folding origami at any energy scale (United States)

    Pinson, Matthew B.; Stern, Menachem; Carruthers Ferrero, Alexandra; Witten, Thomas A.; Chen, Elizabeth; Murugan, Arvind


    Programmable stiff sheets with a single low-energy folding motion have been sought in fields ranging from the ancient art of origami to modern meta-materials research. Despite such attention, only two extreme classes of crease patterns are usually studied; special Miura-Ori-based zero-energy patterns, in which crease folding requires no sheet bending, and random patterns with high-energy folding, in which the sheet bends as much as creases fold. We present a physical approach that allows systematic exploration of the entire space of crease patterns as a function of the folding energy. Consequently, we uncover statistical results in origami, finding the entropy of crease patterns of given folding energy. Notably, we identify three classes of Mountain-Valley choices that have widely varying `typical' folding energies. Our work opens up a wealth of experimentally relevant self-folding origami designs not reliant on Miura-Ori, the Kawasaki condition or any special symmetry in space.

  8. Kinematics of large scale asymmetric folds and associated smaller ...

    Indian Academy of Sciences (India)

    The present work reiterates the importance of analysis of ... these models is the assumption that the folds are passive folds ... applicability of these models is thus limited in the case of ...... with contrasted rheological properties, a theory for the.

  9. Phonosurgery of vocal fold polyps, cysts and nodules is beneficial

    DEFF Research Database (Denmark)

    Jensen, Jane Bjerg; Rasmussen, Niels


    This study reports our experience with microscopic phonosurgery (PS) of benign lesions of the vocal folds.......This study reports our experience with microscopic phonosurgery (PS) of benign lesions of the vocal folds....

  10. Effect of basement structure and salt tectonics on deformation styles along strike: An example from the Kuqa fold-thrust belt, West China (United States)

    Neng, Yuan; Xie, Huiwen; Yin, Hongwei; Li, Yong; Wang, Wei


    The Kuqa fold-thrust belt (KFTB) has a complex thrust-system geometry and comprises basement-involved thrusts, décollement thrusts, triangle zones, strike-slip faults, transpressional faults, and pop-up structures. These structures, combined with the effects of Paleogene salt tectonics and Paleozoic basement uplift form a complex structural zone trending E-W. Interpretation and comprehensive analysis of recent high-quality seismic data, field observations, boreholes, and gravity data covering the KFTB has been performed to understand the characteristics and mechanisms of the deformation styles along strike. Regional sections, fold-thrust system maps of the surface and the sub-salt layer, salt and basement structure distribution maps have been created, and a comprehensive analysis of thrust systems performed. The results indicate that the thrust-fold system in Paleogene salt range can be divided into five segments from east to west: the Kela-3, Keshen, Dabei, Bozi, and Awate segments. In the easternmost and westernmost parts of the Paleogene salt range, strike-slip faulting and basement-involved thrusting are the dominant deformation styles, as basement uplift and the limits of the Cenozoic evaporite deposit are the main controls on deformation. Salt-core detachment fold-thrust systems coincide with areas of salt tectonics, and pop-up, imbricate, and duplex structures are associated with the main thrust faults in the sub-salt layer. Distribution maps of thrust systems, basement structures, and salt tectonics show that Paleozoic basement uplift controlled the Paleozoic foreland basin morphology and the distribution of Cenozoic salt in the KFTB, and thus had a strong influence on the segmented structural deformation and evolution of the fold-thrust belt. Three types of transfer zone are identified, based on the characteristics of the salt layer and basement uplift, and the effects of these zones on the fault systems are evaluated. Basement uplift and the boundary of

  11. Diagnostic and therapeutic pitfalls in benign vocal fold diseases (United States)

    Bohlender, Jörg


    More than half of patients presenting with hoarseness show benign vocal fold changes. The clinician should be familiar with the anatomy, physiology and functional aspects of voice disorders and also the modern diagnostic and therapeutic possibilities in order to ensure an optimal and patient specific management. This review article focuses on the diagnostic and therapeutic limitations and difficulties of treatment of benign vocal fold tumors, the management and prevention of scarred vocal folds and the issue of unilateral vocal fold paresis. PMID:24403969

  12. Folds in multilayered rocks of Proterozoic age, Rajasthan, India

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    Johnson and Johnson 2002 etc) shows that the fold shape modification may be brought about by buckling and flattening operating simultaneously throughout the development of fold. In the present paper a series of F1 folds devel- oped in slates with interlayered alternations with quartzite of Proterozoic age and unaffected ...

  13. Nomenclature proposal to describe vocal fold motion impairment

    NARCIS (Netherlands)

    Rosen, Clark A.; Mau, Ted; Remacle, Marc; Hess, Markus; Eckel, Hans E.; Young, VyVy N.; Hantzakos, Anastasios; Yung, Katherine C.; Dikkers, Frederik G.


    The terms used to describe vocal fold motion impairment are confusing and not standardized. This results in a failure to communicate accurately and to major limitations of interpreting research studies involving vocal fold impairment. We propose standard nomenclature for reporting vocal fold

  14. Nomenclature proposal to describe vocal fold motion impairment

    NARCIS (Netherlands)

    Rosen, Clark A.; Mau, Ted; Remacle, Marc; Hess, Markus; Eckel, Hans E.; Young, VyVy N.; Hantzakos, Anastasios; Yung, Katherine C.; Dikkers, Frederik G.

    The terms used to describe vocal fold motion impairment are confusing and not standardized. This results in a failure to communicate accurately and to major limitations of interpreting research studies involving vocal fold impairment. We propose standard nomenclature for reporting vocal fold

  15. Factors that affect coseismic folds in an overburden layer (United States)

    Zeng, Shaogang; Cai, Yongen


    Coseismic folds induced by blind thrust faults have been observed in many earthquake zones, and they have received widespread attention from geologists and geophysicists. Numerous studies have been conducted regarding fold kinematics; however, few have studied fold dynamics quantitatively. In this paper, we establish a conceptual model with a thrust fault zone and tectonic stress load to study the factors that affect coseismic folds and their formation mechanisms using the finite element method. The numerical results show that the fault dip angle is a key factor that controls folding. The greater the dip angle is, the steeper the fold slope. The second most important factor is the overburden thickness. The thicker the overburden is, the more gradual the fold. In this case, folds are difficult to identify in field surveys. Therefore, if a fold can be easily identified with the naked eye, the overburden is likely shallow. The least important factors are the mechanical parameters of the overburden. The larger the Young's modulus of the overburden is, the smaller the displacement of the fold and the fold slope. Strong horizontal compression and vertical extension in the overburden near the fault zone are the main mechanisms that form coseismic folds.

  16. Technique to achieve the symmetry of the new inframammary fold (United States)

    Pozzi, Marcello; Zoccali, Giovanni; Buccheri, Ernesto Maria; de Vita, Roy


    Summary The literature outlines several surgical techniques to restore inframmammary fold definition, but symmetry of the fold is often left to irreproducible procedures. We report our personal technique to restore the symmetry of the inframmammary fold during multistep breast reconstruction. PMID:25078934


    Energy Technology Data Exchange (ETDEWEB)

    Wesley K. Wallace; Catherine L. Hanks; Jerry Jensen; Michael T. Whalen


    increases in resistance upward. The Alapah consists of a lower resistant member (100 m) of alternating limestone and chert, a middle recessive member (100 m), and an upper resistant member (260 m) that is similar to Wahoo in the northeastern Brooks Range. The Wahoo is recessive and is thin (30 m) due either to non-deposition or erosion beneath the sub-Permian unconformity. The Lisburne of the area records two major episodes of transgression and shallowing-upward on a carbonate ramp. Thicknesses and facies vary along depositional strike. Asymmetrical folds, mostly truncated by thrust faults, were studied in and south of the local range front. Fold geometry was documented by surveys of four thrust-truncated folds and two folds not visibly cut by thrusts. A portion of the local range front was mapped to document changes in fold geometry along strike in three dimensions. The folds typically display a long, non-folded gently to moderately dipping backlimbs and steep to overturned forelimbs, commonly including parasitic anticline-syncline pairs. Thrusts commonly cut through the anticlinal forelimb or the forward synclinal hinge. These folds probably originated as detachment folds based on their mechanical stratigraphy and the transition to detachment folds to the north. Their geometry indicates that they were asymmetrical prior to thrust truncation. This asymmetry may have favored accommodation of increasing shortening by thrust breakthrough rather than continued folding. Fracture patterns were documented in the gently dipping panel of Lisburne and the asymmetrical folds within it. Four sets of steeply dipping extension fractures were identified, with strikes to the (1) N, (2) E, (3) N to NW, and (4) NE. The relative timing of these fracture sets is complex and unclear. En echelon sets of fractures are common, and display normal or strike-slip sense. Mesoscopic and penetrative structures are locally well developed, and indicate bed-parallel shear within the flat panel and strain

  18. Folding very short peptides using molecular dynamics.

    Directory of Open Access Journals (Sweden)

    Bosco K Ho


    Full Text Available Peptides often have conformational preferences. We simulated 133 peptide 8-mer fragments from six different proteins, sampled by replica-exchange molecular dynamics using Amber7 with a GB/SA (generalized-Born/solvent-accessible electrostatic approximation to water implicit solvent. We found that 85 of the peptides have no preferred structure, while 48 of them converge to a preferred structure. In 85% of the converged cases (41 peptides, the structures found by the simulations bear some resemblance to their native structures, based on a coarse-grained backbone description. In particular, all seven of the beta hairpins in the native structures contain a fragment in the turn that is highly structured. In the eight cases where the bioinformatics-based I-sites library picks out native-like structures, the present simulations are largely in agreement. Such physics-based modeling may be useful for identifying early nuclei in folding kinetics and for assisting in protein-structure prediction methods that utilize the assembly of peptide fragments.

  19. Delayed Collapse of Wooden Folding Stairs (United States)

    Krentowski, Janusz; Chyzy, Tadeusz


    During operation of folding stairs, a fastener joining the ladder hanger with the frame was torn off. A person using the stairs sustained serious injury. In several dozen other locations similar accidents were observed. As a result of inspections, some threaded parts of the screws were found in the gaps between the wooden elements of the stairs’ flaps. In the construction a hatch made of wooden strips is attached to an external frame by means of metal hangers. Laboratory strength tests were conducted on three samples made of wooden elements identical to the ones used in the damaged stairs. Due to complex load distribution mechanism acting on the base of the structure, a three-dimensional FEM model was created. An original software was used for calculations. Five computational model variants were considered. As a result of the numerical analyses, it was unquestionably shown that faulty connections were the cause of the destruction of the stairs. The weakest link in the load transmission chain were found to have been the screws connecting the hatch board with the hangers.

  20. Folding and unfolding phylogenetic trees and networks. (United States)

    Huber, Katharina T; Moulton, Vincent; Steel, Mike; Wu, Taoyang


    Phylogenetic networks are rooted, labelled directed acyclic graphswhich are commonly used to represent reticulate evolution. There is a close relationship between phylogenetic networks and multi-labelled trees (MUL-trees). Indeed, any phylogenetic network N can be "unfolded" to obtain a MUL-tree U(N) and, conversely, a MUL-tree T can in certain circumstances be "folded" to obtain aphylogenetic network F(T) that exhibits T. In this paper, we study properties of the operations U and F in more detail. In particular, we introduce the class of stable networks, phylogenetic networks N for which F(U(N)) is isomorphic to N, characterise such networks, and show that they are related to the well-known class of tree-sibling networks. We also explore how the concept of displaying a tree in a network N can be related to displaying the tree in the MUL-tree U(N). To do this, we develop aphylogenetic analogue of graph fibrations. This allows us to view U(N) as the analogue of the universal cover of a digraph, and to establish a close connection between displaying trees in U(N) and reconciling phylogenetic trees with networks.

  1. The pathophysiology of the nodular and micronodular small bowel fold

    International Nuclear Information System (INIS)

    Olmsted, W.W.; Ros, P.R.; Moser, R.P.; Shekita, K.M.; Lichtenstein, J.E.


    The normal small bowel fold is easily seen on conventional studies of the small intestine, but visualization of the small bowel villus is at the limit of resolution of current roentgenographic technique. When the villi are enlarged, they appear radiographically as an irregularity or micronodularity of the small bowel fold. The anatomy of the fold and the pathophysiology of diseases producing fold nodularity (tumor,inflammatory disease, NLH, mastocytosis) and micronodularity (lymphangiectasia, Waldenstrom macroglobulinemia, Whipple disease) are presented, with an emphasis on radiologic-pathologic correlation. The radiologist should suggest certain diseases or conditions based on the roentgenographic characteristics of the closely analyzed small bowel fold

  2. Pathophysiology of the nodular and micronodular small bowel fold

    International Nuclear Information System (INIS)

    Olmstead, W.W.; Ros, P.R.; Moser, R.P.; Shekitka, K.M.; Lichtenstein, J.E.; Buck, J.L.


    The normal small bowel fold is easily seen on conventional studies of the small intestine, but visualization of the small bowel villus is just at the resolution of current roentgenographic technique. When the villi are enlarged, they can be seen radiographically as an irregularity or micronodularity of the small bowel fold. The anatomy of the fold and the pathophysiology of diseases producing fold nodularity (tumor, inflammatory disease, NLH, mastocytosis) and micronodularity (lymphangiectasia, Waldenstrom macroglobulinemia, Whipple disease) are presented, with an emphasis on radiologic-pathologic correlation. The radiologist should suggest certain diseases or conditions based on the roentgenographic characteristics of the closely analyzed small bowel fold

  3. Paleoambientes sedimentarios de la Formación Toro Negro (Neógeno, antepaís fracturado andino, noroeste argentino Sedimentary paleoenvironments of the Toro Negro Formation (Neogene, Andean broken foreland, northwest Argentina

    Directory of Open Access Journals (Sweden)

    Patricia L Ciccioli


    Full Text Available La Formación Toro Negro (Neógeno registra parte de la sedimentación de la cuenca de antepaís fracturado de Vinchina (Orogenia Andina en el NW argentino. Esta unidad está compuesta por conglomerados, areniscas y pelitas junto con algunos niveles de brechas y tobas depositados principalmente en ambientes continentales. Once asociaciones de facies (AF fueron reconocidas: ocho corresponden al miembro inferior y tres al superior. La AFI está compuesta por megabrechas intraformacionales y conglomerados depositados en ríos entrelazados gravosos que rellenaron el paleovalle fluvial en el norte del área. La AFII, formada por brechas intraformacionales y areniscas integrando fajas de canales fuertemente incisas dentro una planicie aluvial, fue identificada en las posiciones marginales del mencionado paleovalle. La AFIII, integrada por fajas de canales gravosos con planicies arenosas, corresponde a ríos anastomosados de clima semiárido que evolucionó a un sistema con espesas planicies fangosas con delgados desbordamientos arenosos y canales simples gravosos (AFIV. Por su parte, la AFV consiste de complejos de canales arenosos encapsulados con ciclos grano-crecientes. La AFVI está compuesta por conglomerados y areniscas guijarrosas depositadas en una planicie entrelazada que evoluciona a un sistema fluvial de menor energía (AFVII caracterizado por un aumento de depósitos fangosos con lóbulos arenosos y lentes gravosas. La AFVIII está dominada por sedimentos finos depositados en un lago somero. En el miembro superior, la AFIX corresponde a un sistema fluvial entrelazado profundo gravoso. La AFX está compuesta por facies finas acumuladas en una planicie aluvial fuertemente agradante sobre la que progradan depósitos gruesos correspondiente a un piedemonte dominado por flujos canalizados (AFXI. En la evolución paleoambiental de la Formación Toro Negro se reconocen 3 etapas. La etapa I (Mioceno Temprano corresponde a la formación de un

  4. NW Iberia Shelf Dynamics. Study of the Douro River Plume.

    Directory of Open Access Journals (Sweden)

    Isabel Iglesias


    Full Text Available River plumes are one of the most important mechanisms that transport the terrestrial materials to the coast and the ocean. Some examples of those materials are pollutants, essential nutrients, which enhance the phytoplankton productivity or sediments, which settle on the seabed producing modifications on the bathymetry affecting the navigation channels. The mixing between the riverine and the oceanic waters can induce instabilities, which might generate bulges, filaments, and buoyant currents over the continental shelf. Offshore, the buoyant riverine water could form a front with the oceanic waters often related with the occurrence of current-jets, eddies and strong mixing. The study and modelling of the river plumes is a key factor for the complete understanding of sediment transport mechanisms and patterns, and of coastal physics and dynamic processes. On this study the Douro River plume will be simulated. The Douro River is located on the north-west Iberian coast and its daily averaged freshwater discharge can range values from 0 to 13000 m3/s. This variability impacts the formation of the river plumes and its dispersion along the continental shelf. This study builds on the long-term objective of generate a Douro River plume forecasting system as part of the RAIA and projects. Satellite imagery was analyzed showing that the river Douro is one of the main sources of suspended particles, dissolved material and chlorophyll in the NW Iberian Shelf. The Regional Oceanic Modeling System (ROMS model was selected to reproduce scenarios of plume generation, retention and dispersion. Whit this model, three types of simulations were performed: (i schematic winds simulations with prescribed river flow, wind speed and direction; (ii multi-year climatological simulation, with river flow and temperature change for each month; (iii extreme case simulation, based on the Entre-os-Rios accident situation. The schematic wind case-studies suggest that the

  5. Protein Folding Free Energy Landscape along the Committor - the Optimal Folding Coordinate. (United States)

    Krivov, Sergei V


    Recent advances in simulation and experiment have led to dramatic increases in the quantity and complexity of produced data, which makes the development of automated analysis tools very important. A powerful approach to analyze dynamics contained in such data sets is to describe/approximate it by diffusion on a free energy landscape - free energy as a function of reaction coordinates (RC). For the description to be quantitatively accurate, RCs should be chosen in an optimal way. Recent theoretical results show that such an optimal RC exists; however, determining it for practical systems is a very difficult unsolved problem. Here we describe a solution to this problem. We describe an adaptive nonparametric approach to accurately determine the optimal RC (the committor) for an equilibrium trajectory of a realistic system. In contrast to alternative approaches, which require a functional form with many parameters to approximate an RC and thus extensive expertise with the system, the suggested approach is nonparametric and can approximate any RC with high accuracy without system specific information. To avoid overfitting for a realistically sampled system, the approach performs RC optimization in an adaptive manner by focusing optimization on less optimized spatiotemporal regions of the RC. The power of the approach is illustrated on a long equilibrium atomistic folding simulation of HP35 protein. We have determined the optimal folding RC - the committor, which was confirmed by passing a stringent committor validation test. It allowed us to determine a first quantitatively accurate protein folding free energy landscape. We have confirmed the recent theoretical results that diffusion on such a free energy profile can be used to compute exactly the equilibrium flux, the mean first passage times, and the mean transition path times between any two points on the profile. We have shown that the mean squared displacement along the optimal RC grows linear with time as for

  6. Design and simulation of origami structures with smooth folds. (United States)

    Peraza Hernandez, E A; Hartl, D J; Lagoudas, D C


    Origami has enabled new approaches to the fabrication and functionality of multiple structures. Current methods for origami design are restricted to the idealization of folds as creases of zeroth-order geometric continuity. Such an idealization is not proper for origami structures of non-negligible fold thickness or maximum curvature at the folds restricted by material limitations. For such structures, folds are not properly represented as creases but rather as bent regions of higher-order geometric continuity. Such fold regions of arbitrary order of continuity are termed as smooth folds . This paper presents a method for solving the following origami design problem: given a goal shape represented as a polygonal mesh (termed as the goal mesh ), find the geometry of a single planar sheet, its pattern of smooth folds, and the history of folding motion allowing the sheet to approximate the goal mesh. The parametrization of the planar sheet and the constraints that allow for a valid pattern of smooth folds are presented. The method is tested against various goal meshes having diverse geometries. The results show that every determined sheet approximates its corresponding goal mesh in a known folded configuration having fold angles obtained from the geometry of the goal mesh.

  7. Single-Chain Folding of Synthetic Polymers: A Critical Update. (United States)

    Altintas, Ozcan; Barner-Kowollik, Christopher


    The current contribution serves as a critical update to a previous feature article from us (Macromol. Rapid Commun. 2012, 33, 958-971), and highlights the latest advances in the preparation of single chain polymeric nanoparticles and initial-yet promising-attempts towards mimicking the structure of natural biomacromolecules via single-chain folding of well-defined linear polymers via so-called single chain selective point folding and repeat unit folding. The contribution covers selected examples from the literature published up to ca. September 2015. Our aim is not to provide an exhaustive review but rather highlight a selection of new and exciting examples for single-chain folding based on advanced macromolecular precision chemistry. Initially, the discussion focuses on the synthesis and characterization of single-chain folded structures via selective point folding. The second part of the feature article addresses the folding of well-defined single-chain polymers by means of repeat unit folding. The current state of the art in the field of single-chain folding indicates that repeat unit folding-driven nanoparticle preparation is well-advanced, while initial encouraging steps towards building selective point folding systems have been taken. In addition, a summary of the-in our view-open key questions is provided that may guide future biomimetic design efforts. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Accurately controlled sequential self-folding structures by polystyrene film (United States)

    Deng, Dongping; Yang, Yang; Chen, Yong; Lan, Xing; Tice, Jesse


    Four-dimensional (4D) printing overcomes the traditional fabrication limitations by designing heterogeneous materials to enable the printed structures evolve over time (the fourth dimension) under external stimuli. Here, we present a simple 4D printing of self-folding structures that can be sequentially and accurately folded. When heated above their glass transition temperature pre-strained polystyrene films shrink along the XY plane. In our process silver ink traces printed on the film are used to provide heat stimuli by conducting current to trigger the self-folding behavior. The parameters affecting the folding process are studied and discussed. Sequential folding and accurately controlled folding angles are achieved by using printed ink traces and angle lock design. Theoretical analyses are done to guide the design of the folding processes. Programmable structures such as a lock and a three-dimensional antenna are achieved to test the feasibility and potential applications of this method. These self-folding structures change their shapes after fabrication under controlled stimuli (electric current) and have potential applications in the fields of electronics, consumer devices, and robotics. Our design and fabrication method provides an easy way by using silver ink printed on polystyrene films to 4D print self-folding structures for electrically induced sequential folding with angular control.

  9. Vocal fold paresis - a debilitating and underdiagnosed condition. (United States)

    Harris, G; O'Meara, C; Pemberton, C; Rough, J; Darveniza, P; Tisch, S; Cole, I


    To review the clinical signs of vocal fold paresis on laryngeal videostroboscopy, to quantify its impact on patients' quality of life and to confirm the benefit of laryngeal electromyography in its diagnosis. Twenty-nine vocal fold paresis patients were referred for laryngeal electromyography. Voice Handicap Index 10 results were compared to 43 patients diagnosed with vocal fold paralysis. Laryngeal videostroboscopy analysis was conducted to determine side of paresis. Blinded laryngeal electromyography confirmed vocal fold paresis in 92.6 per cent of cases, with vocal fold lag being the most common diagnostic sign. The laryngology team accurately predicted side of paresis in 76 per cent of cases. Total Voice Handicap Index 10 responses were not significantly different between vocal fold paralysis and vocal fold paresis groups (26.08 ± 0.21 and 22.93 ± 0.17, respectively). Vocal fold paresis has a significant impact on quality of life. This study shows that laryngeal electromyography is an important diagnostic tool. Patients with persisting dysphonia and apparently normal vocal fold movement, who fail to respond to appropriate speech therapy, should be investigated for a diagnosis of vocal fold paresis.

  10. Quantitative electromyographic characteristics of idiopathic unilateral vocal fold paralysis. (United States)

    Chang, Wei-Han; Fang, Tuan-Jen; Li, Hsueh-Yu; Jaw, Fu-Shan; Wong, Alice M K; Pei, Yu-Cheng


    Unilateral vocal fold paralysis with no preceding causes is diagnosed as idiopathic unilateral vocal fold paralysis. However, comprehensive guidelines for evaluating the defining characteristics of idiopathic unilateral vocal fold paralysis are still lacking. In the present study, we hypothesized that idiopathic unilateral vocal fold paralysis may have different clinical and neurologic characteristics from unilateral vocal fold paralysis caused by surgical trauma. Retrospective, case series study. Patients with unilateral vocal fold paralysis were evaluated using quantitative laryngeal electromyography, videolaryngostroboscopy, voice acoustic analysis, the Voice Outcome Survey, and the Short Form-36 Health Survey quality-of-life questionnaire. Patients with idiopathic and iatrogenic vocal fold paralysis were compared. A total of 124 patients were recruited. Of those, 17 with no definite identified causes after evaluation and follow-up were assigned to the idiopathic group. The remaining 107 patients with surgery-induced vocal fold paralysis were assigned to the iatrogenic group. Patients in the idiopathic group had higher recruitment of the thyroarytenoid-lateral cricoarytenoid muscle complex and better quality of life compared with the iatrogenic group. Idiopathic unilateral vocal fold paralysis has a distinct clinical presentation, with relatively minor denervation changes in the involved laryngeal muscles, and less impact on quality of life compared with iatrogenic vocal fold paralysis. 4. Laryngoscope, 126:E362-E368, 2016. © 2016 The American Laryngological, Rhinological and Otological Society, Inc.

  11. Earthquakes, gravity, and the origin of the Bali Basin: An example of a Nascent Continental Fold-and-Thrust Belt (United States)

    McCaffrey, Robert; Nabelek, John


    We infer from the bathymetry and gravity field and from the source mechanisms and depths of the eight largest earthquakes in the Bali region that the Bali Basin is a downwarp in the crust of the Sunda Shelf produced and maintained by thrusting along the Flores back arc thrust zone. Earthquake source mechanisms and focal depths are inferred from the inversion of long-period P and SH waves for all events and short-period P waves for two of the events. Centroidal depths that give the best fit to the seismograms range from 10 to 18 km, but uncertainties in depth allow a range from 7 to 24 km. The P wave nodal planes that dip south at 13° to 35° (±7°) strike roughly parallel to the volcanic arc and are consistent with thrusting of crust of the Bali Basin beneath it. The positions of the earthquakes with respect to crustal features inferred from seismic and gravity data suggest that the earthquakes occur in the basement along the western end of the Flores thrust zone. The slip direction for the back arc thrust zone inferred from the orientation of the earthquake slip vectors indicates that the thrusting in the Bali Basin is probably part of the overall plate convergence, as it roughly coincides with the convergence direction between the Sunda arc and the Indian Ocean plate. Summation of seismic moments of earthquakes between 1960 and 1985 suggests a minimum rate of convergence across the thrust zone of 4 ± 2 mm/a. The presence of back arc thrusting suggests that some coupling between the Indian Ocean plate and the Sunda arc occurs but mechanisms such as continental collision or a shallow subduction of the Indian Ocean plate probably can be ruled out. The present tectonic setting and structure of the Bali Basin is comparable to the early forelands of the Andes or western North America in that a fold-and-thrust belt is forming on the continental side of an arc-trench system at which oceanic lithosphere is being subducted. The Bali Basin is flanked by the Tertiary Java

  12. Paleosol at the Archean–Proterozoic contact in NW India revisited ...

    Indian Academy of Sciences (India)

    1. Department of Geology, University of Rajasthan, Jaipur 302 004, India. 2. Institut für .... region around Udaipur (NW India) large occur- rences of .... top of the section reddish colors (iron-oxide leach- ..... for Witwatersrand gold; Soc. Econ.

  13. A new structural interpretation relating NW Libya to the Hun Graben ...

    Indian Academy of Sciences (India)

    1.03) stereonet software, produced by Pangaea Scientific Ltd. The aim of this ... influence of basement fabrics of different ages on the subsequent structural development of NW Libya. 1. Introduction ...... formation with application to Britain; Oliver Boyd,. Edinburgh .... Price N J 1966 Fault and Joint Development in Brittle and.

  14. System-Level Sensitivity Analysis of SiNW-bioFET-Based Biosensing Using Lockin Amplification

    DEFF Research Database (Denmark)

    Patou, François; Dimaki, Maria; Kjærgaard, Claus


    carry out for the first time the system-level sensitivity analysis of a generic SiNW-bioFET model coupled to a custom-design instrument based on the lock-in amplifier. By investigating a large parametric space spanning over both sensor and instrumentation specifications, we demonstrate that systemwide...

  15. Radon/helium studies for earthquake prediction N-W Himalaya

    International Nuclear Information System (INIS)

    Virk, H.S.


    The paper presents the preliminary data of radon monitoring stated in the Himalayan orogenic belt. Radon anomalies are correlated with microseismic activity in the N-W Himalaya. The He/Rn ratio will be used as a predictive tool for earthquakes

  16. Effect of ocean warming and acidification on a plankton community in the NW Mediterranean Sea

    NARCIS (Netherlands)

    Maugendre, L.; Gattuso, J.-P.; Louis, J.; de Kluijver, A.; Marro, S.; Soetaert, K.; Gazeau, F.


    The effect of ocean warming and acidification was investigated on a natural plankton assemblage from an oligotrophic area, the bay of Villefranche (NW Mediterranean Sea). The assemblage was sampled in March 2012 and exposed to the following four treatments for 12 days: control (~360 µatm, 14°C),

  17. 10 years of protein crystallography at AR-NW12A beamline (United States)

    Chavas, L. M. G.; Yamada, Y.; Hiraki, M.; Igarashi, N.; Matsugaki, N.; Wakatsuki, S.


    The exponential growth of protein crystallography can be observed in the continuously increasing demand for synchrotron beam time, both from academic and industrial users. Nowadays, the screening of a profusion of sample crystals for more and more projects is being implemented by taking advantage of fully automated procedures at every level of the experiments. The insertion device AR-NW12A beamline is one of the five macromolecular crystallography (MX) beamlines at the Photon Factory (PF). Currently the oldest MX beamline operational at the High Energy Accelerator Research Organization (KEK), the end-station was launched in 2001 as part of an upgrade of the PF Advanced Ring. Since its commissioning, AR-NW12A has been operating as a high-throughput beamline, slowly evolving to a multipurpose end-station for MX experiments. The development of the beamline took place about a decade ago, in parallel with a drastic development of protein crystallography and more general synchrotron technology. To keep the beamline up-to-date and competitive with other MX stations in Japan and worldwide, new features have been constantly added, with the goal of user friendliness of the various beamline optics and other instruments. Here we describe the evolution of AR-NW12A for its tenth anniversary. We also discuss the plans for upgrades for AR-NW12A, the future objectives in terms of the beamline developments, and especially the strong desire to open the beamline to a larger user community.

  18. Suspended sediment transport in the Gulf of Lions (NW Mediterranean): Impact of extreme storms and floods

    NARCIS (Netherlands)

    Ulses, C.; Estournel, C.; Durrieu de Madron, X.; Palanques, A.


    In situ observations were combined with 3D modeling to gain understanding of and to quantify the suspended sediment transport in the Gulf of Lions (NW Mediterranean Sea). The outputs of a hydrodynamic–sediment transport coupled model were compared to near-bottom current and suspended sediment

  19. High-grade metamorphic rocks of the Mellid area, Galicia, NW Spain

    NARCIS (Netherlands)

    Hubregtse, J.J.M.W.


    This study concerns the petrology of the Mellid area, the SE portion of the outer zone of the Ordenes Complex which is one of the upthrusted Precambrian complexes in the axial zone of the Hercynian orogen in Galicia, NW Spain. An eugeosynclinal rock sequence is found containing units with different

  20. The age of volcanic tuffs from the Upper Freshwater Molasse (North Alpine Foreland Basin) and their possible use for tephrostratigraphic correlations across Europe for the Middle Miocene (United States)

    Rocholl, Alexander; Schaltegger, Urs; Gilg, H. Albert; Wijbrans, Jan; Böhme, Madelaine


    The Middle Miocene Upper Freshwater Molasse sediments represent the last cycle of clastic sedimentation during the evolution of the North Alpine Foreland Basin. They are characterized by small-scale lateral and temporal facies changes that make intra-basin stratigraphic correlations at regional scale difficult. This study provides new U-Pb zircon ages as well as revised 40Ar/39Ar data of volcanic ash horizons in the Upper Freshwater Molasse sediments from southern Germany and Switzerland. In a first and preliminary attempt, we propose their possible correlation to other European tephra deposits. The U-Pb zircon data of one Swiss (Bischofszell) and seven southern German (Zahling, Hachelstuhl, Laimering, Unterneul, Krumbad, Ponholz) tuff horizons indicate eruption ages between roughly 13.0 and 15.5 Ma. The stratigraphic position of the Unterneul and Laimering tuffs, bracketing the ejecta of the Ries impact (Brockhorizon), suggests that the Ries impact occurred between 14.93 and 15.00 Ma, thus assigning the event to the reversed chron C5Bn1r (15.032-14.870 Ma) which is in accordance with paleomagnetic evidence. We combine our data with published ages of tuff horizons from Italy, Switzerland, Bavaria, Styria, Hungary, and Romania to derive a preliminary tephrochronological scheme for the Middle Miocene in Central Europe in the age window from 13.2 to 15.5 Ma. The scheme is based on the current state of knowledge that the Carpathian-Pannonian volcanic field was the only area in the region producing explosive calc-alkaline felsic volcanism. This preliminary scheme will require verification by more high-quality ages complemented by isotopic, geochemical and paleomagnetic data.

  1. On the presence of upper paleocene rocks in the foreland succession at Cabo Nariz, Tierra del Fuego, Chile: Geology and new palynological and U-Pb data

    International Nuclear Information System (INIS)

    Sanchez, Alejandro; Pavlishina, Polina; Godoy, Estanislao; Herve, Francisco; Fanning, C.Mark


    On the west coast of Tierra del Fuego, south of Cabo Nariz, in Chile, Upper Cretaceous to Paleocene sedimentary successions of the Magallanes foreland basin crop out. The presence of dinoflagellate cysts, as well as radiometric U-Pb SHPJMP dating of detrital zircons, indicate that this succession ranges from the Campanian to Thanetian (Late Paleocene) in age. The base of the exposed sedimentary succession comprises siltstones of external platform facies (Cerro Cuchilla Formation), which are thrust over the Cabo Nariz Beds. The latter fonnation is divided into two members: a lower siltstone-dominated turbidite facies member and an upper member of sandstone-dominated turbidites, with sandstone and conglomerate channel facies. The presence of dinocysts in the Cerro Cuchilla Formation suggests a late Campanian to early Danian age. The fossil content in the Cabo Nariz Beds indicate a Selandian (Middle Paleocene) depositional age in accordance with the detrital zircon ages which provide a maximum possible Campanian age (76.5±0.7 Ma), and very close to the Thanetian (Late Paleocene) (57.6±1 Ma) depositional ages for the lower and upper member, respectively. The sedimentary succession of Cabo Nariz Beds, is interpreted as a north-northwest prograding submarine fan of middle to Late Paleocene age. It is considered to represent the deposition of detritus derived from an uplifting orogen located to the south. The detrital zircon age spectra suggest that there was a period of low intensity of magmatic activity in the source area around the K-T boundary

  2. Along-Strike Differences of the Main Himalayan Thrust and Deformation within the Indian Crust: Insights from Seismicity and Seismic Velocities in Bhutan and its Foreland (United States)

    Diehl, T.; Singer, J.; Hetényi, G.; Kissling, E. H.; Clinton, J. F.


    The seismicity of Bhutan is characterized by the apparent lack of great earthquakes and a significantly lower activity compared to most other parts of the Himalayan arc. To better understand the underlying mechanisms of this anomalously low activity and to relate it with possible along-strike differences in the structure of the orogenic belt, a temporary network with up to 38 broadband seismometers was installed in Bhutan between January 2013 and November 2014. In this work we present a catalog of local and regional earthquakes detected and located with the GANSSER network complemented by regional stations in India, Bangladesh, and China. State-of-the-art data analysis and earthquake location procedures were applied to derive a high-precision earthquake catalog of Bhutan and surrounding regions. Focal mechanisms from regional moment tensor inversions and first-motion polarities complement the earthquake catalog. In the vicinity of the Shumar-Kuru Chu Spur in East Bhutan, seismicity forms a moderately dipping structure at about 12 km depth, which we associate with the Main Himalayan Thrust (MHT). North of 27.6°N the dip of the structure steepens, which can be interpreted as a ramp along the MHT. In West Bhutan seismicity occurs at depths of 20 to 40 km and receiver function images indicate that seismicity occurs in the underthrusting Indian crust rather than on the MHT. The highest seismic activity is clustered along the Goalpara Lineament, a dextral NE-SW striking shear zone in southwest Bhutan, which appears to connect to the western edge of the Shillong Plateau in the foreland. Focal depths indicate that this shear zone is located at depths of 20-30 km and therefore in the underthrusting Indian crust. Preliminary results of a 3D local earthquake tomography show substantial differences in the uppermost crust between east and west Bhutan. Consistent with our receiver function images, the results also indicate a thinning of the crustal root towards eastern Bhutan.

  3. The Comparison of Detrital Zircon Ages to Point Count Provenance Analysis for the Pottsville Sandstone in the Northern Appalachian Foreland Basin Venango County, Pennsylvania (United States)

    Loveday, S.; Harris, D. B.; Schiappa, T.; Pecha, M.


    The specific sources of sediments deposited in the Appalachian basin prior to and immediately following the Alleghenian orogeny has long been a topic of debate. Recent advances in U-Pb dating of detrital zircons have greatly helped to determine some of the sources of these sediments. For this study, sandstone samples were collected from the Pottsville Formation in the northern Appalachian Foreland Basin, Venango County, Pennsylvania to provide supplementary data for previous work that sought to describe the provenance of the same sediments by point counts of thin sections of the same units. Results of this previous work established that the provenance for these units was transitional recycled orogenic, including multiple recycled sediments, and that a cratonic contribution was not able to be determined clearly. The previous results suggested that the paleoenvironment was a fluvial dominated delta prograding in the northern direction. However, no geochronologic data was found during this study to confirm this interpretation. We sought to verify these results by U-Pb analysis of detrital zircons. Samples were collected from the areas where the previous research took place. U-Pb ages were found from sample at the highest elevation and lowest elevation. In the first sample, sample 17SL01 (younger sample stratigraphically), the zircons yield U-Pb age range peaks at 442-468 ma and 1037-1081 ma. The probability density plot for this specific sample displays a complete age gap from 500 ma to 811 ma. In the second sample, sample 17SL03 (older rock stratigraphically), the zircons yield U-Pb ages range peaks of 424-616 ma and 975-1057 ma. This sample doesn't show any ages younger than 424 ma and it doesn't display the sample age gap as sample 17SL01 does. The ages of zircons are consistent with thin section point counting provenance results from previous research suggesting zircon transport from the northern direction.

  4. Cation-induced folding of alginate-bearing bilayer gels: an unusual example of spontaneous folding along the long axis. (United States)

    Athas, Jasmin C; Nguyen, Catherine P; Kummar, Shailaa; Raghavan, Srinivasa R


    The spontaneous folding of flat gel films into tubes is an interesting example of self-assembly. Typically, a rectangular film folds along its short axis when forming a tube; folding along the long axis has been seen only in rare instances when the film is constrained. Here, we report a case where the same free-swelling gel film folds along either its long or short axis depending on the concentration of a solute. Our gels are sandwiches (bilayers) of two layers: a passive layer of cross-linked N,N'-dimethylyacrylamide (DMAA) and an active layer of cross-linked DMAA that also contains chains of the biopolymer alginate. Multivalent cations like Ca2+ and Cu2+ induce these bilayer gels to fold into tubes. The folding occurs instantly when a flat film of the gel is introduced into a solution of these cations. The likely cause for folding is that the active layer stiffens and shrinks (because the alginate chains in it get cross-linked by the cations) whereas the passive layer is unaffected. The resulting mismatch in swelling degree between the two layers creates internal stresses that drive folding. Cations that are incapable of cross-linking alginate, such as Na+ and Mg2+, do not induce gel folding. Moreover, the striking aspect is the direction of folding. When the Ca2+ concentration is high (100 mM or higher), the gels fold along their long axis, whereas when the Ca2+ concentration is low (40 to 80 mM), the gels fold along their short axis. We hypothesize that the folding axis is dictated by the inhomogeneous nature of alginate-cation cross-linking, i.e., that the edges get cross-linked before the faces of the gel. At high Ca2+ concentration, the stiffer edges constrain the folding; in turn, the gel folds such that the longer edges are deformed less, which explains the folding along the long axis. At low Ca2+ concentration, the edges and the faces of the gel are more similar in their degree of cross-linking; therefore, the gel folds along its short axis. An analogy

  5. The Ventricular-Fold Dynamics in Human Phonation


    Bailly , Lucie; Henrich Bernardoni , Nathalie; Müller , Frank; Rohlfs , Anna-Katharina; Hess , Markus


    International audience; Purpose: In this study, the authors aimed (a) to provide a classification of the ventricular-fold dynamics during voicing, (b) to study the aerodynamic impact of these motions on vocal-fold vibrations, and (c) to assess whether ventricularfold oscillations could be sustained by aerodynamic coupling with the vocal folds. Method: A 72-sample database of vocal gestures accompanying different acoustical events comprised highspeed cinematographic, audio, and electroglottogr...

  6. Comparing the Folding and Misfolding Energy Landscapes of Phosphoglycerate Kinase


    Agocs, Gergely; Szabo, Bence T.; Koehler, Gottfried; Osvath, Szabolcs


    Partitioning of polypeptides between protein folding and amyloid formation is of outstanding pathophysiological importance. Using yeast phosphoglycerate kinase as model, here we identify the features of the energy landscape that decide the fate of the protein: folding or amyloidogenesis. Structure formation was initiated from the acid-unfolded state, and monitored by fluorescence from 10 ms to 20 days. Solvent conditions were gradually shifted between folding and amyloidogenesis, and the prop...

  7. Ligand-promoted protein folding by biased kinetic partitioning. (United States)

    Hingorani, Karan S; Metcalf, Matthew C; Deming, Derrick T; Garman, Scott C; Powers, Evan T; Gierasch, Lila M


    Protein folding in cells occurs in the presence of high concentrations of endogenous binding partners, and exogenous binding partners have been exploited as pharmacological chaperones. A combined mathematical modeling and experimental approach shows that a ligand improves the folding of a destabilized protein by biasing the kinetic partitioning between folding and alternative fates (aggregation or degradation). Computationally predicted inhibition of test protein aggregation and degradation as a function of ligand concentration are validated by experiments in two disparate cellular systems.

  8. Iterative Controller Tuning for Process with Fold Bifurcations

    DEFF Research Database (Denmark)

    Huusom, Jakob Kjøbsted; Poulsen, Niels Kjølstad; Jørgensen, Sten Bay


    Processes involving fold bifurcation are notoriously difficult to control in the vicinity of the fold where most often optimal productivity is achieved . In cases with limited process insight a model based control synthesis is not possible. This paper uses a data driven approach with an improved...... version of iterative feedback tuning to optimizing a closed loop performance criterion, as a systematic tool for tuning process with fold bifurcations....

  9. Current Understanding and Future Directions for Vocal Fold Mechanobiology (United States)

    Li, Nicole Y.K.; Heris, Hossein K.; Mongeau, Luc


    The vocal folds, which are located in the larynx, are the main organ of voice production for human communication. The vocal folds are under continuous biomechanical stress similar to other mechanically active organs, such as the heart, lungs, tendons and muscles. During speech and singing, the vocal folds oscillate at frequencies ranging from 20 Hz to 3 kHz with amplitudes of a few millimeters. The biomechanical stress associated with accumulated phonation is believed to alter vocal fold cell activity and tissue structure in many ways. Excessive phonatory stress can damage tissue structure and induce a cell-mediated inflammatory response, resulting in a pathological vocal fold lesion. On the other hand, phonatory stress is one major factor in the maturation of the vocal folds into a specialized tri-layer structure. One specific form of vocal fold oscillation, which involves low impact and large amplitude excursion, is prescribed therapeutically for patients with mild vocal fold injuries. Although biomechanical forces affect vocal fold physiology and pathology, there is little understanding of how mechanical forces regulate these processes at the cellular and molecular level. Research into vocal fold mechanobiology has burgeoned over the past several years. Vocal fold bioreactors are being developed in several laboratories to provide a biomimic environment that allows the systematic manipulation of physical and biological factors on the cells of interest in vitro. Computer models have been used to simulate the integrated response of cells and proteins as a function of phonation stress. The purpose of this paper is to review current research on the mechanobiology of the vocal folds as it relates to growth, pathogenesis and treatment as well as to propose specific research directions that will advance our understanding of this subject. PMID:24812638

  10. Competition between folding and glycosylation in the endoplasmic reticulum

    DEFF Research Database (Denmark)

    Holst, B; Bruun, A W; Kielland-Brandt, Morten


    Using carboxypeptidase Y in Saccharomyces cerevisiae as a model system, the in vivo relationship between protein folding and N-glycosylation was studied. Seven new sites for N-glycosylation were introduced at positions buried in the folded protein structure. The level of glycosylation of such new...... acceptor sites. In some cases, all the newly synthesized mutant protein was modified at the novel site while in others no modification took place. In the most interesting category of mutants, the level of glycosylation was dependent on the conditions for folding. This shows that folding and glycosylation...

  11. Folding System for the Clothes by a Robot and Tools


    大澤, 文明; 関, 啓明; 神谷, 好承


    The works of a home robot has the laundering. The purpose of this study is to find a means of folding of the clothes and store the clothes in a drawer by a home robot. Because the shape of cloth tends to change in various ways depending on the situation, it is difficult for robot hands to fold the clothes. In this paper, we propose a realistic folding system for the clothes by a robot and tools. The function of a tool is folding the clothes in half by inserting the clothes using two plates. T...

  12. Thermodynamics of protein folding: a random matrix formulation. (United States)

    Shukla, Pragya


    The process of protein folding from an unfolded state to a biologically active, folded conformation is governed by many parameters, e.g. the sequence of amino acids, intermolecular interactions, the solvent, temperature and chaperon molecules. Our study, based on random matrix modeling of the interactions, shows, however, that the evolution of the statistical measures, e.g. Gibbs free energy, heat capacity, and entropy, is single parametric. The information can explain the selection of specific folding pathways from an infinite number of possible ways as well as other folding characteristics observed in computer simulation studies. © 2010 IOP Publishing Ltd

  13. Specific features of vocal fold paralysis in functional computed tomography

    International Nuclear Information System (INIS)

    Laskowska, K.; Mackiewicz-Nartowicz, H.; Serafin, Z.; Nawrocka, E.


    Vocal fold paralysis is usually recognized in laryngological examination, and detailed vocal fold function may be established based on laryngovideostroboscopy. Additional imaging should exclude any morphological causes of the paresis, which should be treated pharmacologically or surgically. The aim of this paper was to analyze the computed tomography (CT) images of the larynx in patients with unilateral vocal fold paralysis. CT examinations of the larynx were performed in 10 patients with clinically defined unilateral vocal fold paralysis. The examinations consisted of unenhanced acquisition and enhanced 3-phased acquisition: during free breathing, Valsalva maneuver, and phonation. The analysis included the following morphologic features of the paresis.the deepened epiglottic vallecula, the deepened piriform recess, the thickened and medially positioned aryepiglottic fold, the widened laryngeal pouch, the anteriorly positioned arytenoid cartilage, the thickened vocal fold, and the filled infraglottic space in frontal CT reconstruction. CT images were compared to laryngovideostroboscopy. The most common symptoms of vocal cord paralysis in CT were the deepened epiglottic vallecula and piriform recess, the widened laryngeal pouch with the filled infraglottic space, and the thickened aryepiglottic fold. Regarding the efficiency of the paralysis determination, the three functional techniques of CT larynx imaging used did not differ significantly, and laryngovideostroboscopy demonstrated its advantage over CT. CT of the larynx is a supplementary examination in the diagnosis of vocal fold paralysis, which may enable topographic analysis of the fold dysfunction. The knowledge of morphological CT features of the paralysis may help to prevent false-positive diagnosis of laryngeal cancer. (author)

  14. Arytenoid and posterior vocal fold surgery for bilateral vocal fold immobility. (United States)

    Young, VyVy N; Rosen, Clark A


    Many procedures exist to address the airway restriction often seen with bilateral vocal fold immobility. We review the most recent studies involving arytenoid and/or posterior vocal fold surgery to provide an update on the issues related to these procedures. Specific focus is placed on selection of the surgical approach and operative side, use of adjunctive therapies, and outcome measures including decannulation rate, revision and complication rate, and postoperative results. Ten studies were identified between 2004 and 2011. Modifications to the orginal transverse cordotomy and medial arytenoidectomy techniques continue to be investigated to seek improvement in dyspnea symptoms with minimal decline in voice and/or swallowing function. Decannulation rates for these approaches are high. Postoperative dysphagia appears to be less commonly observed but requires continued study. The use of mitomycin-C in these procedures has been poorly studied to date. Both transverse cordotomy and medial arytenoidectomy procedures result in high success rates. However, many questions related to these procedures remain unanswered, particularly with respect to preoperative and postoperative evaluations of voice quality, swallowing function, and pulmonary status. There is need for rigorous prospective clinical studies to address these many issues further.

  15. Endo-extralaryngeal Laterofixation of the Vocal Folds in Patients with Bilateral Vocal Fold Immobility. (United States)

    Wiegand, Susanne; Teymoortash, Afshin; Hanschmann, Holger


    Bilateral vocal fold paralysis can result in shortness of breath and severe dyspnea which can be life-threatening. Thirty-five patients with bilateral vocal fold paralysis who underwent endo-extralaryngeal laterofixation according to Lichtenberger were retrospectively analyzed regarding etiology, symptoms, treatment and complications. In 27 patients, laterofixation of the vocal cord alone was performed. Eight patients underwent laterofixation and additional posterior chordectomy of the opposite vocal cord according to Dennis and Kashima. The time of intervention ranged from 1 day to 38 years after the onset of bilateral vocal cord immobility. The intraoperative course was uneventful in all patients. None of the patients had postoperative aspiration. Postoperative voice function was acceptable in all patients. Complications of suture laterofixation were laryngeal edema, formation of fibrin, and malposition of the suture. Laterofixation of the vocal cords according to Lichtenberger is a safe and easy method that can be used as a first-stage treatment of vocal cord paralysis. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  16. Crustal investigations of the earthquake-prone Vrancea region in Romania - Part 2: Novel deep seismic reflection experiment in the southeastern Carpathian belt and its foreland basin - survey target, design, and first results (United States)

    Mocanu, V. I.; Stephenson, R. A.; Diaconescu, C. C.; Knapp, J. H.; Matenco, L.; Dinu, C.; Harder, S.; Prodehl, C.; Hauser, F.; Raileanu, V.; Cloetingh, S. A.; Leever, K.


    Seismic studies of the outer Carpathian Orogen and its foreland (Focsani Basin) in the vicinity of the Vrancea Zone and Danube Delta (Romania) forms one component of a new multidisciplinary initiative of ISES (Netherlands Centre for Integrated Solid Earth Sciences) called DACIA PLAN ("Danube and Carpathian Integrated Action on Processes in the Lithosphere and Neotectonics"). The study area, at the margin of the European craton, constitutes one of the most active seismic zones in Europe, yet has remained a geological and geodynamic enigma within the Alpine-Himalayan orogenic system. Intermediate depth (50-220 km) mantle earthquakes of significant magnitude occur in a geographically restricted area in the south-east Carpathians bend. The adjacent, foreland Focsani Basin appears to exhibit recent extensional deformation in what is otherwise understood to be a zone of convergence. The deep seismic reflection component of DACIA PLAN comprises a ~140-km near-vertical profile across the Vrancea Zone and Focsani Basin. Data acquisition took place in August-September 2001, as part of the integrated refraction/reflection seismic field programme "Vrancea-2001" co-ordinated at Karlsruhe University (cf. Abstract, Part 1), utilising 640 independently deployed recorders provided by UTEP and IRIS/PASSCAL ("Texans"). Station spacing was every 100-m with shots every 1-km. These data are to be integrated with industry seismic as well as planned new medium-high resolution seismic reflection profiling across key neotectonically active structures in the Focsani Basin. Particular goals of DACIA PLAN include: (1) the architecture of the Tertiary/Quaternary basins developed within and adjacent to this zone, including the foreland Focsani Basin; (2) the presence and geometry of structural detachment(s) in relation with foreland basin development, including constraints for balanced cross-sections and geodynamic modelling of basin origin and evolution; (3) the relationship between crustal

  17. An improved evaluation of the seismic/geodetic deformation-rate ratio for the Zagros Fold-and-Thrust collisional belt (United States)

    Palano, Mimmo; Imprescia, Paola; Agnon, Amotz; Gresta, Stefano


    We present an improved picture of the ongoing crustal deformation field for the Zagros Fold-and-Thrust Belt continental collision zone by using an extensive combination of both novel and published GPS observations. The main results define the significant amount of oblique Arabia-Eurasia convergence currently being absorbed within the Zagros: right-lateral shear along the NW trending Main Recent fault in NW Zagros and accommodated between fold-and-thrust structures and NS right-lateral strike-slip faults on Southern Zagros. In addition, taking into account the 1909-2016 instrumental seismic catalogue, we provide a statistical evaluation of the seismic/geodetic deformation-rate ratio for the area. On Northern Zagros and on the Turkish-Iranian Plateau, a moderate to large fraction (˜49 and >60 per cent, respectively) of the crustal deformation occurs seismically. On the Sanandaj-Sirjan zone, the seismic/geodetic deformation-rate ratio suggests that a small to moderate fraction (<40 per cent) of crustal deformation occurs seismically; locally, the occurrence of large historic earthquakes (M ≥ 6) coupled with the high geodetic deformation, could indicate overdue M ≥ 6 earthquakes. On Southern Zagros, aseismic strain dominates crustal deformation (the ratio ranges in the 15-33 per cent interval). Such aseismic deformation is probably related to the presence of the weak evaporitic Hormuz Formation which allows the occurrence of large aseismic motion on both subhorizontal faults and surfaces of décollement. These results, framed into the seismotectonic framework of the investigated region, confirm that the fold-and-thrust-dominated deformation is driven by buoyancy forces; by contrast, the shear-dominated deformation is primary driven by plate stresses.

  18. Incidence of vocal fold immobility in patients with dysphagia. (United States)

    Leder, Steven B; Ross, Douglas A


    This study prospectively investigated the incidence of vocal fold immobility, unilateral and bilateral, and its influence on aspiration status in a referred population of 1452 patients for a dysphagia evaluation from a large, urban, tertiary-care, teaching hospital. Main outcome measures included overall incidence of vocal fold immobility and aspiration status, with specific emphasis on age, etiology, and side of vocal fold immobility, i.e., right, left, or bilateral. Overall incidence of vocal fold immobility was 5.6% (81 of 1452 patients), including 47 males (mean age 55.7 yr) and 34 females (mean age 59.7 yr). In the subgroup of patients with vocal fold immobility, 31% (25 of 81) exhibited unilateral right, 60% (49 of 81) unilateral left, and 9% (7 of 81) bilateral impairment. Overall incidence of aspiration was found to be 29% (426 of 1452) of all patients referred for a swallow evaluation. Aspiration was observed in 44% (36 of 81) of patients presenting with vocal fold immobility, i.e., 44% (11 of 25) unilateral right, 43% (21 of 49) unilateral left, and 57% (4 of 7) bilateral vocal fold immobility. Left vocal fold immobility occurred most frequently due to surgical trauma. A liquid bolus was aspirated more often than a puree bolus. Side of vocal fold immobility and age were not factors that increased incidence of aspiration. In conclusion, vocal fold immobility, with an incidence of 5.6%, is not an uncommon finding in patients referred for a dysphagia evaluation in the acute-care setting, and vocal fold immobility, when present, was associated with a 15% increased incidence of aspiration when compared with a population already being evaluated for dysphagia.

  19. In vivo measurement of vocal fold surface resistance. (United States)

    Mizuta, Masanobu; Kurita, Takashi; Dillon, Neal P; Kimball, Emily E; Garrett, C Gaelyn; Sivasankar, M Preeti; Webster, Robert J; Rousseau, Bernard


    A custom-designed probe was developed to measure vocal fold surface resistance in vivo. The purpose of this study was to demonstrate proof of concept of using vocal fold surface resistance as a proxy of functional tissue integrity after acute phonotrauma using an animal model. Prospective animal study. New Zealand White breeder rabbits received 120 minutes of airflow without vocal fold approximation (control) or 120 minutes of raised intensity phonation (experimental). The probe was inserted via laryngoscope and placed on the left vocal fold under endoscopic visualization. Vocal fold surface resistance of the middle one-third of the vocal fold was measured after 0 (baseline), 60, and 120 minutes of phonation. After the phonation procedure, the larynx was harvested and prepared for transmission electron microscopy. In the control group, vocal fold surface resistance values remained stable across time points. In the experimental group, surface resistance (X% ± Y% relative to baseline) was significantly decreased after 120 minutes of raised intensity phonation. This was associated with structural changes using transmission electron microscopy, which revealed damage to the vocal fold epithelium after phonotrauma, including disruption of the epithelium and basement membrane, dilated paracellular spaces, and alterations to epithelial microprojections. In contrast, control vocal fold specimens showed well-preserved stratified squamous epithelia. These data demonstrate the feasibility of measuring vocal fold surface resistance in vivo as a means of evaluating functional vocal fold epithelial barrier integrity. Device prototypes are in development for additional testing, validation, and for clinical applications in laryngology. NA Laryngoscope, 127:E364-E370, 2017. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  20. The significance of strike-slip faulting in the basement of the Zagros fold and thrust belt

    Energy Technology Data Exchange (ETDEWEB)

    Hessami, K.; Koyi, H.A.; Talbot, C.J. [Uppsala University (Sweden). Institute of Earth Sciences


    Lateral offsets in the pattern of seismicity along the Zagros fold and thrust belt indicate that transverse faults segmenting the Arabian basement are active deep-seated strike-slip faults. The dominant NW-SE trending features of the belt have undergone repeated horizontal displacements along these transverse faults. These reactivated basement faults, which are inherited from the Pan-African construction phase, controlled both deposition of the Phanerozoic cover before Tertiary-Recent deformation of the Zagros and probably the entrapment of hydrocarbons on the NE margin of Arabia and in the Zagros area. We have used observations of faulting recognized on Landsat satellite images, in conjunction with the spatial distribution of earthquakes and their focal mechanism solutions, to infer a tectonic model for the Zagros basement. Deformation in the NW Zagros appears to be concentrated on basement thrusts and a few widely-spaced north-south trending strike-slip faults which separate major structural segments. In the SE Zagros, two main structural domains can be distinguished. A domain of NNW-trending right-lateral faults in the northern part of the SE Zagros implies that fault-bounded blocks are likely to have rotated anticlockwise about vertical axes relative to both Arabia and Central Iran. In contrast, the predominance of NNE-trending left-lateral faults in the southern part of the SE Zagros implies that fault-bounded blocks may have rotated clockwise about vertical axes. We propose a tectonic model in which crustal blocks bounded by strike-slip faults in a zone of simple shear rotate about vertical axes relative to both Arabia and Central Iran. The presence of domains of strike-slip and thrust faulting in the Zagros basement suggest that some of the convergence between Arabia and Central Iran is accommodated by rotation and possible lateral movement of crust along the belt by strike-slip faults, as well as by obvious crustal shortening and thickening along thrust

  1. Control of preexisting faults and near-surface diapirs on geometry and kinematics of fold-and-thrust belts (Internal Prebetic, Eastern Betic Cordillera) (United States)

    Pedrera, Antonio; Marín-Lechado, Carlos; Galindo-Zaldívar, Jesús; García-Lobón, José Luis


    We have determined, for the first time, the 3D geometry of a sector of the eastern Internal Prebetic comprised between Parcent and Altea diapirs, combining structural, borehole and multichannel seismic reflection data. The tectonic structure of the Jurassic-Cretaceous carbonate series is characterized by regional ENE-WSW fold-and-thrusts that interact with oblique N-S and WNW-ESE folds, detached over Triassic evaporites and clays. The structural style comprises box-shape anticlines, and N-vergent anticlines with vertical to overturned limbs frequently bordered by reverse and strike-slip faults. The anticlines surround a triangular broad synclinal structure, the Tárbena basin, filled by a late Oligocene to Tortonian sedimentary sequence that recorded folding and thrusting history. The location and geometrical characteristics of fold-and-thrusts may be controlled by the positive inversion of pre-existing Mesozoic normal faults, and by the position and shape of near-surface diapirs composed of Triassic rocks. Therefore, we propose an initial near-surface diapir emplacement of Triassic evaporitic rocks driven by late Jurassic to early Cretaceous rifting of the southern Iberian paleomargin. Thrusting and folding started during the latest Oligocene (∼28-23 Ma) roughly orthogonal to the NW-directed shortening. Deformation migrated to the south during Aquitanian (∼23-20 Ma), when tectonic inversion implied the left-lateral transpressive reactivation of N-S striking former normal faults and right-lateral/reverse reactivation of inherited WNW-ESE faults. We show two mechanisms driving the extrusion of the diapirs during contraction: lateral migration of a pre-existing near-surface diapir associated with dextral transpression; and squeezing of a previous near-surface diapir at the front of an anticline. Our study underlines the value of 3D geological modeling to characterize geometry and kinematics of complex fold-and-thrust belts influenced by preexisting faults and

  2. Status report on the folded tandem ion accelerator at BARC

    Indian Academy of Sciences (India)

    Folded tandem ion accelerator; charged particle beams; voltage stability; Rutherford backscattering; ion optics; beam lines. Abstract. The folded tandem ion accelerator (FOTIA) facility set up at BARC has become operational. At present, it is used for elemental analysis studies using the Rutherford backscattering technique.

  3. The effect of surface electrical stimulation on vocal fold position. (United States)

    Humbert, Ianessa A; Poletto, Christopher J; Saxon, Keith G; Kearney, Pamela R; Ludlow, Christy L


    Closure of the true and false vocal folds is a normal part of airway protection during swallowing. Individuals with reduced or delayed true vocal fold closure can be at risk for aspiration and may benefit from intervention to ameliorate the problem. Surface electrical stimulation is currently used during therapy for dysphagia, despite limited knowledge of its physiological effects. Prospective single effects study. The immediate physiological effect of surface stimulation on true vocal fold angle was examined at rest in 27 healthy adults using 10 different electrode placements on the submental and neck regions. Fiberoptic nasolaryngoscopic recordings during passive inspiration were used to measure change in true vocal fold angle with stimulation. Vocal fold angles changed only to a small extent during two electrode placements (P vocal fold abduction was 2.4 degrees; while horizontal placements of electrodes in the submental region produced a mean adduction of 2.8 degrees (P = .03). Surface electrical stimulation to the submental and neck regions does not produce immediate true vocal fold adduction adequate for airway protection during swallowing, and one position may produce a slight increase in true vocal fold opening.

  4. Cotranslational protein folding reveals the selective use of ...

    Indian Academy of Sciences (India)

    to fold properly by decelerating the translation rate at these sites. Thus the cotranslational protein folding is believed to be true for many proteins and is an important selection factor for the selective codon usage to optimize proper gene expres- sion and function (Komar 2009). A web server CS and S has been created by ...

  5. Vocal Fold Mucus Aggregation in Persons with Voice Disorders (United States)

    Bonilha, Heather Shaw; White, Lisa; Kuckhahn, Kelsey; Gerlach, Terri Treman; Deliyski, Dimitar D.


    Mucus aggregation on the vocal folds is a common finding from laryngeal endoscopy. Patients with voice disorders report the presence of mucus aggregation. Patients also report that mucus aggregation causes them to clear their throat, a behavior believed to be harmful to vocal fold mucosa. Even though clinicians and patients report and discuss…

  6. Surfing the free energy landscape of flavodoxin folding

    NARCIS (Netherlands)

    Bollen, Y.J.M.


    The research described in this thesis has been carried out to obtain a better understanding of the fundamental rules describing protein folding. Protein folding is the process in which a linear chain of amino acids contracts to a compact state in which it is active. Flavodoxin from Azotobacter

  7. New variants of known folds: do they bring new biology?

    International Nuclear Information System (INIS)

    Koonin, Eugene V.


    New distinct versions of known protein folds provide a powerful means of protein-function prediction that complements sequence and genomic context analysis. New distinct versions of known protein folds provide a powerful means of protein-function prediction that complements sequence and genomic context analysis. These structures do not supplant direct biochemical experiments, but are indispensable for the complete characterization of proteins

  8. Acute vocal fold hemorrhage caught on video during office exam. (United States)

    Carroll, Thomas L; Smith, Libby J


    This article presents a unique video of a laryngeal exam during which a vocal fold hemorrhage occurs. This patient had likely been suffering from intermittent vocal fold hemorrhages for the last decade due to a persistent vascular lesion and an underlying chronic cough.

  9. Transiently disordered tails accelerate folding of globular proteins. (United States)

    Mallik, Saurav; Ray, Tanaya; Kundu, Sudip


    Numerous biological proteins exhibit intrinsic disorder at their termini, which are associated with multifarious functional roles. Here, we show the surprising result that an increased percentage of terminal short transiently disordered regions with enhanced flexibility (TstDREF) is associated with accelerated folding rates of globular proteins. Evolutionary conservation of predicted disorder at TstDREFs and drastic alteration of folding rates upon point-mutations suggest critical regulatory role(s) of TstDREFs in shaping the folding kinetics. TstDREFs are associated with long-range intramolecular interactions and the percentage of native secondary structural elements physically contacted by TstDREFs exhibit another surprising positive correlation with folding kinetics. These results allow us to infer probable molecular mechanisms behind the TstDREF-mediated regulation of folding kinetics that challenge protein biochemists to assess by direct experimental testing. © 2017 Federation of European Biochemical Societies.

  10. Method of generating ploynucleotides encoding enhanced folding variants

    Energy Technology Data Exchange (ETDEWEB)

    Bradbury, Andrew M.; Kiss, Csaba; Waldo, Geoffrey S.


    The invention provides directed evolution methods for improving the folding, solubility and stability (including thermostability) characteristics of polypeptides. In one aspect, the invention provides a method for generating folding and stability-enhanced variants of proteins, including but not limited to fluorescent proteins, chromophoric proteins and enzymes. In another aspect, the invention provides methods for generating thermostable variants of a target protein or polypeptide via an internal destabilization baiting strategy. Internally destabilization a protein of interest is achieved by inserting a heterologous, folding-destabilizing sequence (folding interference domain) within DNA encoding the protein of interest, evolving the protein sequences adjacent to the heterologous insertion to overcome the destabilization (using any number of mutagenesis methods), thereby creating a library of variants. The variants in the library are expressed, and those with enhanced folding characteristics selected.

  11. Folding propensity of intrinsically disordered proteins by osmotic stress

    International Nuclear Information System (INIS)

    Mansouri, Amanda L.; Grese, Laura N.; Rowe, Erica L.


    Proteins imparted with intrinsic disorder conduct a range of essential cellular functions. To better understand the folding and hydration properties of intrinsically disordered proteins (IDPs), we used osmotic stress to induce conformational changes in nuclear co-activator binding domain (NCBD) and activator for thyroid hormone and retinoid receptor (ACTR). Osmotic stress was applied by the addition of small and polymeric osmolytes, where we discovered that water contributions to NCBD folding always exceeded those for ACTR. Both NCBD and ACTR were found to gain a-helical structure with increasing osmotic stress, consistent with their folding upon NCBD/ACTR complex formation. Using small-angle neutron scattering (SANS), we further characterized NCBD structural changes with the osmolyte ethylene glycol. Here a large reduction in overall size initially occurred before substantial secondary structural change. In conclusion, by focusing on folding propensity, and linked hydration changes, we uncover new insights that may be important for how IDP folding contributes to binding.

  12. Thrusting and multiple folding in the Neoproterozoic Pan-African basement of Wadi Hodein area, south Eastern Desert, Egypt (United States)

    Abdeen, M. M.; Sadek, M. F.; Greiling, R. O.


    Detailed field mapping and structural studies of the area around the mouth of Wadi Hodein, some 20 km west of Shalatein at the Red Sea coast in the south Eastern Desert of Egypt, revealed four phases of structural deformation (D1-D4) affecting the Neoproterozoic Pan-African basement rocks. D1 is related to arc-arc collision and is represented by ENE-WSW oriented megascopic upright open folds associated with low angle thrusts and mesoscopic tight, overturned and recumbent F1 folds. Kinematic indicators indicate thrusting towards the SSE. D2 is represented by NNW-SSE oriented megascopic and mesoscopic folds, which are tight, verge towards the WSW and display a left-stepping en echelon pattern. D3 includes major NNW-SSE trending sinistral shear zones that show subordinate reverse fault components and dip steeply towards the ENE. These sinistral shear zones are comparable with the Najd Fault System, as they display a similar sense of movement and relationships to earlier structures. Therefore, they are interpreted to be the continuation of the Najd Shear System in southern Egypt. D2 and D3 are related to accretion of east and west Gondwana. D4 is represented by E-W oriented dextral faults with left-stepping segments. The first three deformation events are in agreement with the general evolutionary model for the East African Orogen in the Arabian-Nubian Shield that begins with NNW-SSE shortening, followed by ENE-WSW compression and subsequent deformation by the NNW-SSE striking Najd Fault System. The E-W dextral faults may be the conjugate shear fractures to the D3 NNW-SSE oriented sinistral wrench faults or are related to a subsequent event, D4. NW-SE oriented gold-bearing quartz veins originated during D1 and were subsequently deformed by D2-D4 events.

  13. Vocal fold contact patterns based on normal modes of vibration. (United States)

    Smith, Simeon L; Titze, Ingo R


    The fluid-structure interaction and energy transfer from respiratory airflow to self-sustained vocal fold oscillation continues to be a topic of interest in vocal fold research. Vocal fold vibration is driven by pressures on the vocal fold surface, which are determined by the shape of the glottis and the contact between vocal folds. Characterization of three-dimensional glottal shapes and contact patterns can lead to increased understanding of normal and abnormal physiology of the voice, as well as to development of improved vocal fold models, but a large inventory of shapes has not been directly studied previously. This study aimed to take an initial step toward characterizing vocal fold contact patterns systematically. Vocal fold motion and contact was modeled based on normal mode vibration, as it has been shown that vocal fold vibration can be almost entirely described by only the few lowest order vibrational modes. Symmetric and asymmetric combinations of the four lowest normal modes of vibration were superimposed on left and right vocal fold medial surfaces, for each of three prephonatory glottal configurations, according to a surface wave approach. Contact patterns were generated from the interaction of modal shapes at 16 normalized phases during the vibratory cycle. Eight major contact patterns were identified and characterized by the shape of the flow channel, with the following descriptors assigned: convergent, divergent, convergent-divergent, uniform, split, merged, island, and multichannel. Each of the contact patterns and its variation are described, and future work and applications are discussed. Copyright © 2018 Elsevier Ltd. All rights reserved.

  14. Provenance and fate of arsenic and other solutes in the Chaco-Pampean Plain of the Andean foreland, Argentina: From perspectives of hydrogeochemical modeling and regional tectonic setting (United States)

    Raychowdhury, Nilasree; Mukherjee, Abhijit; Bhattacharya, Prosun; Johannesson, Karen; Bundschuh, Jochen; Sifuentes, Gabriela Bejarano; Nordberg, Erika; Martin, Raúl A.; Storniolo, Angel del Rosario


    Extensive arsenic (As) enriched groundwater is known to occur in the aquifers of the Chaco-Pampean Plain of Argentina. Previous studies speculated that the As mobilization in these groundwaters was a direct result of their elevated pH and oxidative conditions. The volcanic glass layers present in the aquifer matrix were hypothesized as one of the possible sources of As to the groundwaters. Here, we examine the groundwater chemistry of the Santiago del Estero province of Chaco-Pampean Plains of Argentina, and test these hypotheses by using hydrogeochemical modeling within the framework of the regional geologic-tectonic setting. The study area is located in the active foreland of the Andean orogenic belt, which forms a continental arc setting, and is dotted with several hot springs. Rhyolitic volcanic glass fragments derived from arc volcanism are abundant within the aeolian-fluvial aquifer sediments, and are related to the paleo-igneous extrusion in the vicinity. Hydrogeochemical analyses show that the groundwater is in predominantly oxidative condition. In addition, some of the groundwaters exhibit very high Na, Cl- and SO42- concentrations. It is hypothesized in this study that the groundwater chemistry has largely evolved by dissolution of rhyolitic volcanic glass fragments contained within the aquifer sediments along with mixing with saline surface waters from, adjoining salinas, which are thought to be partially evaporated remnants of a paleo inland sea. Flow path modeling, stability diagrams, and thermodynamic analyses undertaken in this study indicate that the dominant evolutionary processes include ion exchange reactions, chemical weathering of silicate and evaporites, in monosialitization-dominated weathering. Geochemical modeling predicts that plagioclase feldspar and volcanic glass are the major solids phases that contribute metal cations and dissolved silica to the local groundwaters. Co-influxed oxyanions, with similar ionic radii and structure (e.g. Mo

  15. The Cretaceous-Paleogene boundary in the shallow northeastern Mexican foreland basins: Evidence for paleoseismic liquefaction, tsunami deposition, and Chicxulub ejecta (United States)

    Schulte, Peter; Smit, Jan; Deutsch, Alex; Friese, Andrea; Beichel, Kilian


    Understanding the depositional sequence and composition of impact ejecta is critical for the interpretation of timing and effects of the Chicxulub impact regarding the mass extinction at the Cretaceous-Paleogene (K-Pg) boundary. Preliminary investigations have shown that the shallow La Popa and Parras foreland basins in northeastern Mexico both feature outstanding and continuous 3D exposures of the Chicxulub ejecta-rich, K-Pg boundary event deposit (Lawton et al., 2005). The m-thick sand-siltstone interval directly underlying the ejecta-rich mass flows shows evidence of slumping and liquefaction, locally leading to complete disorganization and disruption of the pre-impact late Cretaceous sedimentary sequence. The subsequent ejecta-rich sequence consists of an up to one m-thick basal carbonate-rich bed that discontinuously fills a valley-like topography. Besides abundant silicic and carbonate ejecta spherules (up to 50%) that are excellently preserved, this bed includes abundant mollusks and gastropod shells, as well as vertebrate bones and teeth. The conglomeratic bed is overlain by a series of alternating fine- to medium grained calcareous sandstones with shell debris and ejecta that were deposited by repeated currents / mass flow events incorporating varying source areas. Hummocky-cross-stratified strata that mark the return to a normal out-shelf depositional regime conformably overly these sandstones. We interpret this sequence as evidence for presumably seismic-induced sediment liquefaction followed by a series of impact-related tsunami deposits. The specific depositional sequence and Fe-Mg-rich ejecta composition as well as the petrography of the sandstones all closely link the K-Pg boundary sequence in the La Popa and Parras basin to the well-known deep-water K-Pg sites in the Gulf of Mexico (e.g. El Mimbral; Smit et al., 1996; Schulte and Kontny, 2005). Lawton, T.F., et al., 2005, Geology, v. 33, p. 81-84. Smit, J. et al., 1996, GSA Special Paper v. 307, p

  16. Seismic source characterization of the Alpine foreland in the context of a probabilistic seismic hazard analysis by PEGASOS Expert Group 1 (EG1a)

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, S. M. [Geologisch-Palaeontologisches Institut, University of Basel, Basel (Switzerland); Slejko, D. [Istituto Nazionale di Oceanografia e di Geofisica Sperimentale, Trieste (Italy)


    Seismic source characterization is performed as part of the PEGASOS project for the assessment of the seismic hazard at the 4 sites of the Swiss Nuclear Power Plants. The analysis is performed according to the Level 4 procedures for expert elicitation defined in the guidelines of the US Nuclear Regulatory Committee whereby the quantification of uncertainties plays a crucial role. According to our analysis, which is one amongst four that were performed in the frame of PEGASOS, the most important epistemic uncertainty is related to the question as to whether basement-rooted faults at the margins of pre-existing Permo-Carboniferous troughs are prone for compressive or transpressive reactivation under the present-day stress field or not. The question after the present-day style of deformation in the Alpine foreland (thick-skinned versus thin-skinned) is closely related to this key question. Together with the consideration of uncertainties regarding the mapping of seismogenic zones and/or line sources, alternative zonations are presented in form of a logic tree with 21 branches. Area sources play a predominant role in the working area located at the margin of a diffuse plate boundary. Earthquake recurrence relationships are discussed by taking into account a series of uncertainties. These concern the evaluation of b-values and the evaluation of a-values once the b-values were fixed. Both parameters in the Gutenberg-Richter law are based on non-perfect and incomplete catalogue data that were carefully analysed beforehand. Since PEGASOS demanded an analysis of annual probabilities down to one event in 10{sup 7} years, the question after the value of the maximum possible earthquake magnitude M{sub max} and related error in M{sub max} estimates plays a crucial role. We estimate M{sub max} by using geological as well as statistical methods. M{sub max} = 6.9 cannot be excluded in most areas, in the Basel area M{sub max} = 7.3 is possible. Uncertainties in a, b and M{sub max

  17. Preliminary Feasibility Assessment of Integrating CCHP with NW Food Processing Plant #1: Modeling Documentation

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, Michael G.; Srivastava, Viraj; Wagner, Anne W.; Makhmalbaf, Atefe; Thornton, John


    The Pacific Northwest National Laboratory (PNNL) has launched a project funded by the Bonneville Power Association (BPA) to identify strategies for increasing industrial energy efficiency and reducing energy costs of Northwest Food Processors Association (NWFPA) plants through deployment of novel combinations and designs of variable-output combined heat and power (CHP) distributed generation (DG), combined cooling, heating and electric power (CCHP) DG and energy storage systems. Detailed evaluations and recommendations of CHP and CCHP DG systems will be performed for several Northwest (NW) food processing sites. The objective is to reduce the overall energy use intensity of NW food processors by 25% by 2020 and by 50% by 2030, as well as reducing emissions and understanding potential congestion reduction impacts on the transmission system in the Pacific Northwest.

  18. CRED SVP Drifting Buoy Argos_ID 30291 Data in the NW Hawaiian Islands, 20020920-20050105 (NODC Accession 0049436) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED SVP drifter Argos_ID 30291 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. SVP drifter data files...

  19. CRED APEX Drifting Buoy Argos_ID 24963 Data in the NW Hawaiian Islands, 200109-200506 (NODC Accession 0049436) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED APEX drifter Argos_ID 24963 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. APEX drifter data files...

  20. OXYGEN - AVERAGE SEABED CONSUMPTION from FIXED STATIONS From NW Atlantic (limit-40 W) from 19750429 to 19760126 (NODC Accession 9200021) (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data consists of taut moorings designed for long-duration measurement of temperature/pressure time series in the deep ocean. These data were collected in NW...

  1. High dark inorganic carbon fixation rates by specific microbial groups in the Atlantic off the Galician coast (NW Iberian margin)

    NARCIS (Netherlands)

    Guerrero-Feijóo, E.; Sintes, E.; Herndl, G.J.; Varela, M.M.


    Bulk dark dissolved inorganic carbon (DIC) fixation rates were determined and compared to microbial heterotrophic production in subsurface, meso- and bathypelagic Atlantic waters off the Galician coast (NW Iberian margin). DIC fixation rates were slightly higher than heterotrophic production

  2. CRED APEX Drifting Buoy Argos_ID 26070 Data in the NW Hawaiian Islands, the Pacific Ocean (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — CRED APEX drifter Argos_ID 26070 was deployed in the region of NW Hawaiian Islands to assess ocean currents and sea surface temperature. APEX drifter data files...

  3. Double-gated Si NW FET sensors: Low-frequency noise and photoelectric properties

    International Nuclear Information System (INIS)

    Gasparyan, F.; Khondkaryan, H.; Arakelyan, A.; Zadorozhnyi, I.; Pud, S.; Vitusevich, S.


    The transport, noise, and photosensitivity properties of an array of silicon nanowire (NW) p"+-p-p"+ field-effect transistors (FETs) are investigated. The peculiarities of photosensitivity and detectivity are analyzed over a wide spectrum range. The absorbance of p-Si NW shifts to the short wavelength region compared with bulk Si. The photocurrent and photosensitivity reach increased values in the UV range of the spectrum at 300 K. It is shown that sensitivity values can be tuned by the drain-source voltage and may reach record values of up to 2–4 A/W at a wavelength of 300 nm at room temperature. Low-frequency noise studies allow calculating the photodetectivity values, which increase with decreasing wavelength down to 300 nm. We show that the drain current of Si NW biochemical sensors substantially depends on pH value and the signal-to-noise ratio reaches the high value of 10"5. Increasing pH sensitivity with gate voltage is revealed for certain source-drain currents of pH-sensors based on Si NW FETs. The noise characteristic index decreases from 1.1 to 0.7 with the growth of the liquid gate voltage. Noise behavior is successfully explained in the framework of the correlated number-mobility unified fluctuation model. pH sensitivity increases as a result of the increase in liquid gate voltage, thus giving the opportunity to measure very low proton concentrations in the electrolyte medium at certain values of the liquid gate voltage.

  4. Environmental Risk Assessment of dredging processes – application to Marin harbour (NW Spain)


    A. G. Gómez; J. García Alba; A. Puente; J. A. Juanes


    ABSTRACT. A methodological procedure to estimate the environmental risk of dredging operations in aquatic systems has been developed. Environmental risk estimations are based on numerical models results, which provide an appropriated spatio-temporal framework analysis to guarantee an effective decision-making process. The methodological procedure has been applied on a real dredging operation in the port of Marin (NW Spain). Results from Marin harbour confirmed the suitabi...

  5. Environmental Risk Assessment of dredging processes - application to Marin harbour (NW Spain) (United States)

    Gómez, A. G.; García Alba, J.; Puente, A.; Juanes, J. A.


    A methodological procedure to estimate the environmental risk of dredging operations in aquatic systems has been developed. Environmental risk estimations are based on numerical models results, which provide an appropriated spatio-temporal framework analysis to guarantee an effective decision-making process. The methodological procedure has been applied on a real dredging operation in the port of Marin (NW Spain). Results from Marin harbour confirmed the suitability of the developed methodology and the conceptual approaches as a comprehensive and practical management tool.

  6. Climate and sea level controlled sedimentation processes in two submarine canyons off NW-Africa


    Pierau, Roberto


    This study focuses on the trigger mechanisms of gravity-driven sediment transport in two submarine canyons at the passive continental margin off NW-Africa during the past 240 kyr. The sedimentary records allow to determine the turbidite emplacement times based on high resolution age models. The sediment textures of the turbidites were studied by using X-ray radiographies. The sedimentary properties like the terrigenous silt size distribution and XRF-core scanning element data allow to identif...

  7. Quality-intensity relationships of phosphorus in some soils from NW India

    International Nuclear Information System (INIS)

    Vig, A.C.; Dev, G.


    In a laboratory investigation, Q/I relationship of soil phosphorus in soils derived from four different agroclimatic regions of N.W. India have been worked out on the basis of adsorption studies, involving the use of radioactive phosphorus. These two parameters are related to each other by a Langmuir-like equation. The results indicate that for supply of P, the soils fall in the decreasing order of: Dalhousie, Ludhiana, Gurudaspur, Palampur. (author)

  8. Looking for Larvae Above an Erupting Submarine Volcano, NW Rota-1, Mariana Arc (United States)

    Beaulieu, S.; Hanson, M.; Tunnicliffe, V.; Chadwick, W. W., Jr.; Breuer, E. R.


    In 2009 the first marine protected areas for deep-sea hydrothermal vents in U.S. waters were established as part of the Volcanic Unit of the Marianas Trench Marine National Monument. In this region, hydrothermal vents are located along the Mariana Arc and back-arc spreading center. In particular hydrothermal vents are located near the summit of NW Rota-1, an active submarine volcano on the Mariana Arc which was erupting between 2003 and 2010 and ceased as of 2014. NW Rota-1 experienced a massive landslide in late 2009, decimating the habitat on the southern side of the volcano. This project looked at zooplankton tow samples taken from the water column above NW Rota-1 in 2010, searching for larvae which have the potential to recolonize the sea floor after such a major disturbance. Samples were sorted in entirety into coarse taxa, and then larvae were removed for DNA barcoding. Overall zooplankton composition was dominated by copepods, ostracods, and chaetognaths, the majority of which are pelagic organisms. Comparatively few larvae of benthic invertebrates were found, but shrimp, gastropod, barnacle, and polychaete larvae did appear in low numbers in the samples. Species-level identification obtained via genetic barcoding will allow for these larvae to be matched to species known to inhabit the benthic communities at NW Rota-1. Identified larvae will give insight into the organisms which can re-colonize the seafloor vent communities after a disturbance such as the 2009 landslide. Communities at hydrothermal vents at other submarine volcanoes in the Monument may act as sources for these larvae, but connectivity in this region of complex topography is unknown. As the microinvertebrate biodiversity in the Monument has yet to be fully characterized, our project also provides an opportunity to better describe both the zooplankton and benthic community composition in this area of the Monument.

  9. Entropic formulation for the protein folding process: Hydrophobic stability correlates with folding rates (United States)

    Dal Molin, J. P.; Caliri, A.


    Here we focus on the conformational search for the native structure when it is ruled by the hydrophobic effect and steric specificities coming from amino acids. Our main tool of investigation is a 3D lattice model provided by a ten-letter alphabet, the stereochemical model. This minimalist model was conceived for Monte Carlo (MC) simulations when one keeps in mind the kinetic behavior of protein-like chains in solution. We have three central goals here. The first one is to characterize the folding time (τ) by two distinct sampling methods, so we present two sets of 103 MC simulations for a fast protein-like sequence. The resulting sets of characteristic folding times, τ and τq were obtained by the application of the standard Metropolis algorithm (MA), as well as by an enhanced algorithm (Mq A). The finding for τq shows two things: (i) the chain-solvent hydrophobic interactions {hk } plus a set of inter-residues steric constraints {ci,j } are able to emulate the conformational search for the native structure. For each one of the 103MC performed simulations, the target is always found within a finite time window; (ii) the ratio τq / τ ≅ 1 / 10 suggests that the effect of local thermal fluctuations, encompassed by the Tsallis weight, provides to the chain an innate efficiency to escape from energetic and steric traps. We performed additional MC simulations with variations of our design rule to attest this first result, both algorithms the MA and the Mq A were applied to a restricted set of targets, a physical insight is provided. Our second finding was obtained by a set of 600 independent MC simulations, only performed with the Mq A applied to an extended set of 200 representative targets, our native structures. The results show how structural patterns should modulate τq, which cover four orders of magnitude; this finding is our second goal. The third, and last result, was obtained with a special kind of simulation performed with the purpose to explore a

  10. The role of the mesenchyme in cranial neural fold elevation

    International Nuclear Information System (INIS)

    Morris-Wiman, J.A.


    It has been previously postulated that the expansion of an hyaluronate-rich extracellular matrix in the fold mesenchyme is responsible for neural fold elevation. In this study we provide evidence that such expansions may play an important role in cranial neural fold elevation by pushing the folds towards the dorsal midline to assist in their elevation. For mesenchymal expansion to result in fold elevation, hyaluronate (HA) and mesenchymal cells must be non-randomly distributed within the mesenchyme. Patterns of mesenchymal cell distribution and cell proliferation were analyzed using the computer-assisted method of smoothed spatial averaging. The distribution of Alcian blue-stained and 3 H-glucosamine-labelled HA was also analyzed during cranial neural fold elevation using established image processing techniques. Analysis of the distribution of 3 H-thymidine-labelled mesenchymal cells indicated that differential mitotic activity was not responsible for decreased mesenchymal cell density. Likewise, analysis of distribution patterns of 3 H-glucosamine-labelled HA indicated that decreased HA concentration was not produced by regional differences in HA synthesis. These results suggest that decreases in mesenchymal cell density and HA concentration that occur during neural fold elevation are produced by mesenchymal expansion

  11. Origami-Inspired Folding of Thick, Rigid Panels (United States)

    Trease, Brian P.; Thomson, Mark W.; Sigel, Deborah A.; Walkemeyer, Phillip E.; Zirbel, Shannon; Howell, Larry; Lang, Robert


    To achieve power of 250 kW or greater, a large compression ratio of stowed-to-deployed area is needed. Origami folding patterns were used to inspire the folding of a solar array to achieve synchronous deployment; however, origami models are generally created for near-zero-thickness material. Panel thickness is one of the main challenges of origami-inspired design. Three origami-inspired folding techniques (flasher, square twist, and map fold) were created with rigid panels and hinges. Hinge components are added to the model to enable folding of thick, rigid materials. Origami models are created assuming zero (or near zero) thickness. When a material with finite thickness is used, the panels are required to bend around an increasingly thick fold as they move away from the center of the model. The two approaches for dealing with material thickness are to use membrane hinges to connect the panels, or to add panel hinges, or hinges of the same thickness, at an appropriate width to enable folding.

  12. Unraveling metamaterial properties in zigzag-base folded sheets. (United States)

    Eidini, Maryam; Paulino, Glaucio H


    Creating complex spatial objects from a flat sheet of material using origami folding techniques has attracted attention in science and engineering. In the present work, we use the geometric properties of partially folded zigzag strips to better describe the kinematics of known zigzag/herringbone-base folded sheet metamaterials such as Miura-ori. Inspired by the kinematics of a one-degree of freedom zigzag strip, we introduce a class of cellular folded mechanical metamaterials comprising different scales of zigzag strips. This class of patterns combines origami folding techniques with kirigami. Using analytical and numerical models, we study the key mechanical properties of the folded materials. We show that our class of patterns, by expanding on the design space of Miura-ori, is appropriate for a wide range of applications from mechanical metamaterials to deployable structures at small and large scales. We further show that, depending on the geometry, these materials exhibit either negative or positive in-plane Poisson's ratios. By introducing a class of zigzag-base materials in the current study, we unify the concept of in-plane Poisson's ratio for similar materials in the literature and extend it to the class of zigzag-base folded sheet materials.

  13. Fluorescence of Alexa fluor dye tracks protein folding.

    Directory of Open Access Journals (Sweden)

    Simon Lindhoud

    Full Text Available Fluorescence spectroscopy is an important tool for the characterization of protein folding. Often, a protein is labeled with appropriate fluorescent donor and acceptor probes and folding-induced changes in Förster Resonance Energy Transfer (FRET are monitored. However, conformational changes of the protein potentially affect fluorescence properties of both probes, thereby profoundly complicating interpretation of FRET data. In this study, we assess the effects protein folding has on fluorescence properties of Alexa Fluor 488 (A488, which is commonly used as FRET donor. Here, A488 is covalently attached to Cys69 of apoflavodoxin from Azotobacter vinelandii. Although coupling of A488 slightly destabilizes apoflavodoxin, the three-state folding of this protein, which involves a molten globule intermediate, is unaffected. Upon folding of apoflavodoxin, fluorescence emission intensity of A488 changes significantly. To illuminate the molecular sources of this alteration, we applied steady state and time-resolved fluorescence techniques. The results obtained show that tryptophans cause folding-induced changes in quenching of Alexa dye. Compared to unfolded protein, static quenching of A488 is increased in the molten globule. Upon populating the native state both static and dynamic quenching of A488 decrease considerably. We show that fluorescence quenching of Alexa Fluor dyes is a sensitive reporter of conformational changes during protein folding.

  14. The impact of intraglottal vortices on vocal fold dynamics (United States)

    Erath, Byron; Pirnia, Alireza; Peterson, Sean


    During voiced speech a critical pressure is produced in the lungs that separates the vocal folds and creates a passage (the glottis) for airflow. As air passes through the vocal folds the resulting aerodynamic loading, coupled with the tissue properties of the vocal folds, produces self-sustained oscillations. Throughout each cycle a complex flow field develops, characterized by a plethora of viscous flow phenomena. Air passing through the glottis creates a jet, with periodically-shed vortices developing due to flow separation and the Kelvin-Helmholtz instability in the shear layer. These vortices have been hypothesized to be a crucial mechanism for producing vocal fold vibrations. In this study the effect of vortices on the vocal fold dynamics is investigated experimentally by passing a vortex ring over a flexible beam with the same non-dimensional mechanical properties as the vocal folds. Synchronized particle image velocimetry data are acquired in tandem with the beam dynamics. The resulting impact of the vortex ring loading on vocal fold dynamics is discussed in detail. This work was supported by the National Science Foundation Grant CBET #1511761.

  15. Idiopathic unilateral vocal-fold paralysis in the adult. (United States)

    Rubin, F; Villeneuve, A; Alciato, L; Slaïm, L; Bonfils, P; Laccourreye, O


    To analyze the characteristics of adult idiopathic unilateral vocal-fold paralysis. Retrospective study of diagnostic problems, clinical data and recovery in an inception cohort of 100 adult patients with idiopathic unilateral vocal-fold paralysis (Group A) and comparison with a cohort of 211 patients with isolated non-idiopathic non-traumatic unilateral vocal-fold paralysis (Group B). Diagnostic problems were noted in 24% of cases in Group A: eight patients with concomitant common upper aerodigestive tract infection, five patients with a concomitant condition liable to induce immunodepression and 11 patients in whom a malignant tumor occurred along the path of the ipsilateral vagus and inferior laryngeal nerves or in the ipsilateral paralyzed larynx. There was no recovery of vocal-fold motion beyond 51 months after onset of paralysis. The 5-year actuarial estimate for recovery differed significantly (Pvocal-fold paralysis. In non-traumatic vocal-fold paralysis in adult patients, without recovery of vocal-fold motion, a minimum three years' regular follow-up is recommended. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  16. Climate fluctuations during the Holocene in NW Iberia: High and low latitude linkages (United States)

    Pena, L. D.; Francés, G.; Diz, P.; Esparza, M.; Grimalt, J. O.; Nombela, M. A.; Alejo, I.


    High resolution benthic foraminiferal stable isotopes (δ 18O, δ 13C) and molecular biomarkers in the sediments are used here to infer rapid climatic changes for the last 8200 years in the Ría de Muros (NW Iberian Margin). Benthic foraminiferal δ 18O and δ 13C potentially register migrations in the position of the hydrographic front formed between two different intermediate water masses: Eastern North Atlantic Central Water of subpolar origin (ENACW sp) and subtropical origin (ENACW st). The molecular biomarkers in the sediment show a strong coupling between continental organic matter inputs and negative δ 13C values in benthic foraminifera. The rapid centennial and millennial events registered in these records have been compared with two well known North Atlantic Holocene records from the subtropical Atlantic sea surface temperatures (SST) anomalies off Cape Blanc, NW Africa and the subpolar Atlantic (Hematite Stained Grains percentage, subpolar North Atlantic). Comparison supports a strong link between high- and low-latitude climatic perturbations at centennial-millennial time scales during the Holocene. Spectral analyses also points to a pole-to-equator propagation of the so-called 1500 yr cycles. Our results demonstrate that during the Holocene, the NW Iberian Margin has undergone a series of rapid events which are likely triggered at high latitudes in the North Atlantic and are rapidly propagated towards lower latitudes. Conceivably, the propagation of these rapid climatic changes involves a shift in atmospheric and oceanic circulatory systems.

  17. Landforms along transverse faults parallel to axial zone of folded mountain front, north-eastern Kumaun Sub-Himalaya, India (United States)

    Luirei, Khayingshing; Bhakuni, S. S.; Negi, Sanjay S.


    The shape of the frontal part of the Himalaya around the north-eastern corner of the Kumaun Sub-Himalaya, along the Kali River valley, is defined by folded hanging wall rocks of the Himalayan Frontal Thrust (HFT). Two parallel faults (Kalaunia and Tanakpur faults) trace along the axial zone of the folded HFT. Between these faults, the hinge zone of this transverse fold is relatively straight and along these faults, the beds abruptly change their attitudes and their widths are tectonically attenuated across two hinge lines of fold. The area is constituted of various surfaces of coalescing fans and terraces. Fans comprise predominantly of sandstone clasts laid down by the steep-gradient streams originating from the Siwalik range. The alluvial fans are characterised by compound and superimposed fans with high relief, which are generated by the tectonic activities associated with the thrusting along the HFT. The truncated fan along the HFT has formed a 100 m high-escarpment running E-W for ˜5 km. Quaternary terrace deposits suggest two phases of tectonic uplift in the basal part of the hanging wall block of the HFT dipping towards the north. The first phase is represented by tilting of the terrace sediments by ˜30 ∘ towards the NW; while the second phase is evident from deformed structures in the terrace deposit comprising mainly of reverse faults, fault propagation folds, convolute laminations, flower structures and back thrust faults. The second phase produced ˜1.0 m offset of stratification of the terrace along a thrust fault. Tectonic escarpments are recognised across the splay thrust near south of the HFT trace. The south facing hill slopes exhibit numerous landslides along active channels incising the hanging wall rocks of the HFT. The study area shows weak seismicity. The major Moradabad Fault crosses near the study area. This transverse fault may have suppressed the seismicity in the Tanakpur area, and the movement along the Moradabad and Kasganj

  18. Endoscopic Anatomy of the Tensor Fold and Anterior Attic. (United States)

    Li, Bin; Doan, Phi; Gruhl, Robert R; Rubini, Alessia; Marchioni, Daniele; Fina, Manuela


    Objectives The objectives of the study were to (1) study the anatomical variations of the tensor fold and its anatomic relation with transverse crest, supratubal recess, and anterior epitympanic space and (2) explore the most appropriate endoscopic surgical approach to each type of the tensor fold variants. Study Design Cadaver dissection study. Setting Temporal bone dissection laboratory. Subjects and Methods Twenty-eight human temporal bones (26 preserved and 2 fresh) were dissected through an endoscopic transcanal approach between September 2016 and June 2017. The anatomical variations of the tensor fold, transverse crest, supratubal recess, and anterior epitympanic space were studied before and after removing ossicles. Results Three different tensor fold orientations were observed: vertical (type A, 11/28, 39.3%) with attachment to the transverse crest, oblique (type B, 13/28, 46.4%) with attachment to the anterior tegmen tympani, and horizontal (type C, 4/28, 14.3%) with attachment to the tensor tympani canal. The tensor fold was a complete membrane in 20 of 28 (71.4%) specimens, preventing direct ventilation between the supratubal recess and anterior epitympanic space. We identified 3 surgical endoscopic approaches, which allowed visualization of the tensor fold without removing the ossicles. Conclusions The orientation of the tensor fold is the determining structure that dictates the conformation and limits of the epitympanic space. We propose a classification of the tensor fold based on 3 anatomical variants. We also describe 3 different minimally invasive endoscopic approaches to identify the orientation of the tensor fold while maintaining ossicular chain continuity.

  19. A nomenclature paradigm for benign midmembranous vocal fold lesions. (United States)

    Rosen, Clark A; Gartner-Schmidt, Jackie; Hathaway, Bridget; Simpson, C Blake; Postma, Gregory N; Courey, Mark; Sataloff, Robert T


    There is a significant lack of uniform agreement regarding nomenclature for benign vocal fold lesions (BVFLs). This confusion results in difficulty for clinicians communicating with their patients and with each other. In addition, BVFL research and comparison of treatment methods are hampered by the lack of a detailed and uniform BVFL nomenclature. Clinical consensus conferences were held to develop an initial BVFL nomenclature paradigm. Perceptual video analysis was performed to validate the stroboscopy component of the paradigm. The culmination of the consensus conferences and the video-perceptual analysis was used to evaluate the BVFL nomenclature paradigm using a retrospective review of patients with BVFL. An initial BVFL nomenclature paradigm was proposed utilizing detailed definitions relating to vocal fold lesion morphology, stroboscopy, response to voice therapy and intraoperative findings. Video-perceptual analysis of stroboscopy demonstrated that the proposed binary stroboscopy system used in the BVFL nomenclature paradigm was valid and widely applicable. Retrospective review of 45 patients with BVFL followed to the conclusion of treatment demonstrated that slight modifications of the initial BVFL nomenclature paradigm were required. With the modified BVFL nomenclature paradigm, 96% of the patients fit into the predicted pattern and definitions of the BVFL nomenclature system. This study has validated a multidimensional BVFL nomenclature paradigm. This vocal fold nomenclature paradigm includes nine distinct vocal fold lesions: vocal fold nodules, vocal fold polyp, pseudocyst, vocal fold cyst (subepithelial or ligament), nonspecific vocal fold lesion, vocal fold fibrous mass (subepithelial or ligament), and reactive lesion. Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.

  20. Radiation Fibrosis of the Vocal Fold: From Man to Mouse (United States)

    Johns, Michael M.; Kolachala, Vasantha; Berg, Eric; Muller, Susan; Creighton, Frances X.; Branski, Ryan C.


    Objectives To characterize fundamental late tissue effects in the human vocal fold following radiation therapy. To develop a murine model of radiation fibrosis to ultimately develop both treatment and prevention paradigms. Design Translational study using archived human and fresh murine irradiated vocal fold tissue. Methods 1) Irradiated vocal fold tissue from patients undergoing laryngectomy for loss of function from radiation fibrosis were identified from pathology archives. Histomorphometry, immunohistochemistry, and whole-genome microarray as well as real-time transcriptional analyses was performed. 2) Focused radiation to the head and neck was delivered to mice in a survival fashion. One month following radiation, vocal fold tissue was analyzed with histomorphometry, immunohistochemistry, and real-time PCR transcriptional analysis for selected markers of fibrosis. Results Human irradiated vocal folds demonstrated increased collagen transcription with increased deposition and disorganization of collagen in both the thyroarytenoid muscle and the superficial lamina propria. Fibronectin were increased in the superficial lamina propria. Laminin decreased in the thyroarytenoid muscle. Whole genome microarray analysis demonstrated increased transcription of markers for fibrosis, oxidative stress, inflammation, glycosaminoglycan production and apoptosis. Irradiated murine vocal folds demonstrated increases in collagen and fibronectin transcription and deposition in the lamina propria. Transforming growth factor (TGF)-β increased in the lamina propria. Conclusion Human irradiated vocal folds demonstrate molecular changes leading to fibrosis that underlie loss of vocal fold pliability that occurs in patients following laryngeal irradiation. Irradiated murine tissue demonstrates similar findings, and this mouse model may have utility in creating prevention and treatment strategies for vocal fold radiation fibrosis. PMID:23242839

  1. Recoverable and Programmable Collapse from Folding Pressurized Origami Cellular Solids. (United States)

    Li, S; Fang, H; Wang, K W


    We report a unique collapse mechanism by exploiting the negative stiffness observed in the folding of an origami solid, which consists of pressurized cells made by stacking origami sheets. Such a collapse mechanism is recoverable, since it only involves rigid folding of the origami sheets and it is programmable by pressure control and the custom design of the crease pattern. The collapse mechanism features many attractive characteristics for applications such as energy absorption. The reported results also suggest a new branch of origami study focused on its nonlinear mechanics associated with folding.

  2. Water dynamics clue to key residues in protein folding

    International Nuclear Information System (INIS)

    Gao, Meng; Zhu, Huaiqiu; Yao, Xin-Qiu; She, Zhen-Su


    A computational method independent of experimental protein structure information is proposed to recognize key residues in protein folding, from the study of hydration water dynamics. Based on all-atom molecular dynamics simulation, two key residues are recognized with distinct water dynamical behavior in a folding process of the Trp-cage protein. The identified key residues are shown to play an essential role in both 3D structure and hydrophobic-induced collapse. With observations on hydration water dynamics around key residues, a dynamical pathway of folding can be interpreted.

  3. Microwave-enhanced folding and denaturation of globular proteins

    DEFF Research Database (Denmark)

    Bohr, Henrik; Bohr, Jakob


    It is shown that microwave irradiation can affect the kinetics of the folding process of some globular proteins, especially beta-lactoglobulin. At low temperature the folding from the cold denatured phase of the protein is enhanced, while at a higher temperature the denaturation of the protein from...... its folded state is enhanced. In the latter case, a negative temperature gradient is needed for the denaturation process, suggesting that the effects of the microwaves are nonthermal. This supports the notion that coherent topological excitations can exist in proteins. The application of microwaves...

  4. Protein folding and the organization of the protein topology universe

    DEFF Research Database (Denmark)

    Lindorff-Larsen,, Kresten; Røgen, Peter; Paci, Emanuele


    residues and, in addition, that the topology of the transition state is closer to that of the native state than to that of any other fold in the protein universe. Here, we review the evidence for these conclusions and suggest a molecular mechanism that rationalizes these findings by presenting a view...... of protein folds that is based on the topological features of the polypeptide backbone, rather than the conventional view that depends on the arrangement of different types of secondary-structure elements. By linking the folding process to the organization of the protein structure universe, we propose...

  5. Adjustable thermal resistor by reversibly folding a graphene sheet. (United States)

    Song, Qichen; An, Meng; Chen, Xiandong; Peng, Zhan; Zang, Jianfeng; Yang, Nuo


    Phononic (thermal) devices such as thermal diodes, thermal transistors, thermal logic gates, and thermal memories have been studied intensively. However, tunable thermal resistors have not been demonstrated yet. Here, we propose an instantaneously adjustable thermal resistor based on folded graphene. Through theoretical analysis and molecular dynamics simulations, we study the phonon-folding scattering effect and the dependence of thermal resistivity on the length between two folds and the overall length. Furthermore, we discuss the possibility of realizing instantaneously adjustable thermal resistors in experiment. Our studies bring new insights into designing thermal resistors and understanding the thermal modulation of 2D materials by adjusting basic structure parameters.

  6. Sex Hormone Receptor Expression in the Human Vocal Fold Subunits. (United States)

    Kirgezen, Tolga; Sunter, Ahmet Volkan; Yigit, Ozgur; Huq, Gulben Erdem


    The study aimed to evaluate the existence of sex hormone receptors in the subunits of vocal fold. This is a cadaver study. The androgen, estrogen, and progesterone receptors were examined in the epithelium (EP), superficial layer of the lamina propria (SLP), vocal ligament (VL), and macula flava (MF) of the vocal folds from 42 human cadavers (21 male, 21 female) by immunohistochemical methods. Their staining ratios were scored and statistically compared. The androgen receptor score was significantly higher for the MF than for the EP and SLP (P vocal fold, mostly in the MF and VLs. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  7. Miniaturization of Multiple-Layer Folded Patch Antennas

    DEFF Research Database (Denmark)

    Zhang, Jiaying; Breinbjerg, Olav


    A new folded patch antenna with multiple layers was developed in this paper, by folding the patch in a proper way, and a highly miniaturized antenna can be realized. The multiple layer patch with 4-layer and 6-layer are designed and evaluated at 2.4 GHz, 915 MHz, and 415 MHz respectively. Then a 4...... layer patch is fabricated and measured to validate the design method. The theoretical analysis, design and simulations, fabrications, as well as the measurements are presented in this paper. All the results show that the folded patch antenna is a good candidate in making a highly miniaturized compact...

  8. Endoscopic vocal fold injection using a 25-gauge butterfly needle. (United States)

    Buchanan, M A; Riffat, F; Palme, C E


    To describe a useful technique for infiltrating a bulking agent using a butterfly needle, as part of a transoral endoscopic vocal fold medialisation procedure. This paper describes the procedure of grasping the needle with phonosurgery forceps and administering the injectate to the vocal fold through careful application of the syringe plunger via a length of rubber tubing from outside the mouth. This procedure is performed routinely in our institution without complication. The advantages of this technique are discussed. This is a safe and easy method of injecting into a vocal fold.

  9. 100-fold but not 50-fold dystrophin overexpression aggravates electrocardiographic defects in the mdx model of Duchenne muscular dystrophy

    Directory of Open Access Journals (Sweden)

    Yongping Yue


    Full Text Available Dystrophin gene replacement holds the promise of treating Duchenne muscular dystrophy. Supraphysiological expression is a concern for all gene therapy studies. In the case of Duchenne muscular dystrophy, Chamberlain and colleagues found that 50-fold overexpression did not cause deleterious side effect in skeletal muscle. To determine whether excessive dystrophin expression in the heart is safe, we studied two lines of transgenic mdx mice that selectively expressed a therapeutic minidystrophin gene in the heart at 50-fold and 100-fold of the normal levels. In the line with 50-fold overexpression, minidystrophin showed sarcolemmal localization and electrocardiogram abnormalities were corrected. However, in the line with 100-fold overexpression, we not only detected sarcolemmal minidystrophin expression but also observed accumulation of minidystrophin vesicles in the sarcoplasm. Excessive minidystrophin expression did not correct tachycardia, a characteristic feature of Duchenne muscular dystrophy. Importantly, several electrocardiogram parameters (QT interval, QRS duration and the cardiomyopathy index became worse than that of mdx mice. Our data suggests that the mouse heart can tolerate 50-fold minidystrophin overexpression, but 100-fold overexpression leads to cardiac toxicity.

  10. Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar

    Directory of Open Access Journals (Sweden)

    Angelou Valerie


    Full Text Available Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand rabbits. Sixteen of them were used as control/normal group. We created a bilateral vocal fold wound in the remaining 58 rabbits. After 18 months we separated our population into three groups. The first group served as control/scarred group. The second one was injected with hyaluronic acid in the vocal folds, and the third received an autologous adipose-derived stem cell infusion in the scarred vocal folds (ADSC group. We measured the variation of thickness of the lamina propria of the vocal folds and analyzed histopathologic changes in each group after three months. Results. The thickness of the lamina propria was significantly reduced in the group that received the ADSC injection, as compared to the normal/scarred group. The collagen deposition, the hyaluronic acid, the elastin levels, and the organization of elastic fibers tend to return to normal after the injection of ADSC. Conclusions. Autologous injection of adipose-derived stem cells on a vocal fold chronic scar enhanced the healing of the vocal folds and the reduction of the scar tissue, even when compared to other treatments.

  11. Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar (United States)

    Vassiliki, Kalodimou; Irini, Messini; Nikolaos, Psychalakis; Karampela, Eleftheria; Apostolos, Papalois


    Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand rabbits. Sixteen of them were used as control/normal group. We created a bilateral vocal fold wound in the remaining 58 rabbits. After 18 months we separated our population into three groups. The first group served as control/scarred group. The second one was injected with hyaluronic acid in the vocal folds, and the third received an autologous adipose-derived stem cell infusion in the scarred vocal folds (ADSC group). We measured the variation of thickness of the lamina propria of the vocal folds and analyzed histopathologic changes in each group after three months. Results. The thickness of the lamina propria was significantly reduced in the group that received the ADSC injection, as compared to the normal/scarred group. The collagen deposition, the hyaluronic acid, the elastin levels, and the organization of elastic fibers tend to return to normal after the injection of ADSC. Conclusions. Autologous injection of adipose-derived stem cells on a vocal fold chronic scar enhanced the healing of the vocal folds and the reduction of the scar tissue, even when compared to other treatments. PMID:26933440

  12. RNAslider: a faster engine for consecutive windows folding and its application to the analysis of genomic folding asymmetry. (United States)

    Horesh, Yair; Wexler, Ydo; Lebenthal, Ilana; Ziv-Ukelson, Michal; Unger, Ron


    Scanning large genomes with a sliding window in search of locally stable RNA structures is a well motivated problem in bioinformatics. Given a predefined window size L and an RNA sequence S of size N (L free energy (MFE) for the folding of each of the L-sized substrings of S. The consecutive windows folding problem can be naively solved in O(NL3) by applying any of the classical cubic-time RNA folding algorithms to each of the N-L windows of size L. Recently an O(NL2) solution for this problem has been described. Here, we describe and implement an O(NLpsi(L)) engine for the consecutive windows folding problem, where psi(L) is shown to converge to O(1) under the assumption of a standard probabilistic polymer folding model, yielding an O(L) speedup which is experimentally confirmed. Using this tool, we note an intriguing directionality (5'-3' vs. 3'-5') folding bias, i.e. that the minimal free energy (MFE) of folding is higher in the native direction of the DNA than in the reverse direction of various genomic regions in several organisms including regions of the genomes that do not encode proteins or ncRNA. This bias largely emerges from the genomic dinucleotide bias which affects the MFE, however we see some variations in the folding bias in the different genomic regions when normalized to the dinucleotide bias. We also present results from calculating the MFE landscape of a mouse chromosome 1, characterizing the MFE of the long ncRNA molecules that reside in this chromosome. The efficient consecutive windows folding engine described in this paper allows for genome wide scans for ncRNA molecules as well as large-scale statistics. This is implemented here as a software tool, called RNAslider, and applied to the scanning of long chromosomes, leading to the observation of features that are visible only on a large scale.

  13. Botulinum toxin in the treatment of vocal fold nodules. (United States)

    Allen, Jacqui E; Belafsky, Peter C


    Promising new techniques in the management of vocal fold nodules have been developed in the past 2 years. Simultaneously, the therapeutic use of botulinum toxin has rapidly expanded. This review explores the use of botulinum toxin in treatment of vocal nodules and summarizes current therapeutic concepts. New microsurgical instruments and techniques, refinements in laser technology, radiosurgical excision and steroid intralesional injections are all promising new techniques in the management of vocal nodules. Botulinum toxin-induced 'voice rest' is a new technique we have employed in patients with recalcitrant nodules. Successful resolution of nodules is possible with this technique, without the risk of vocal fold scarring inherent in dissection/excision techniques. Botulinum toxin usage is exponentially increasing, and large-scale, long-term studies demonstrate its safety profile. Targeted vocal fold temporary paralysis induced by botulinum toxin injection is a new, well tolerated and efficacious treatment in patients with persistent vocal fold nodules.

  14. New Analysis and Theory of Deployable Folded Structures, Phase II (United States)

    National Aeronautics and Space Administration — A recently developed mathematical folding theory has great value for deployable space structures and in situ manufacture of large beams, panels and cylinders. The...

  15. RNA inverse folding using Monte Carlo tree search. (United States)

    Yang, Xiufeng; Yoshizoe, Kazuki; Taneda, Akito; Tsuda, Koji


    Artificially synthesized RNA molecules provide important ways for creating a variety of novel functional molecules. State-of-the-art RNA inverse folding algorithms can design simple and short RNA sequences of specific GC content, that fold into the target RNA structure. However, their performance is not satisfactory in complicated cases. We present a new inverse folding algorithm called MCTS-RNA, which uses Monte Carlo tree search (MCTS), a technique that has shown exceptional performance in Computer Go recently, to represent and discover the essential part of the sequence space. To obtain high accuracy, initial sequences generated by MCTS are further improved by a series of local updates. Our algorithm has an ability to control the GC content precisely and can deal with pseudoknot structures. Using common benchmark datasets for evaluation, MCTS-RNA showed a lot of promise as a standard method of RNA inverse folding. MCTS-RNA is available at .

  16. Folding two dimensional crystals by swift heavy ion irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Ochedowski, Oliver; Bukowska, Hanna [Fakultät für Physik and CENIDE, Universität Duisburg-Essen, D-47048 Duisburg (Germany); Freire Soler, Victor M. [Fakultät für Physik and CENIDE, Universität Duisburg-Essen, D-47048 Duisburg (Germany); Departament de Fisica Aplicada i Optica, Universitat de Barcelona, E08028 Barcelona (Spain); Brökers, Lara [Fakultät für Physik and CENIDE, Universität Duisburg-Essen, D-47048 Duisburg (Germany); Ban-d' Etat, Brigitte; Lebius, Henning [CIMAP (CEA-CNRS-ENSICAEN-UCBN), 14070 Caen Cedex 5 (France); Schleberger, Marika, E-mail: [Fakultät für Physik and CENIDE, Universität Duisburg-Essen, D-47048 Duisburg (Germany)


    Ion irradiation of graphene, the showcase model of two dimensional crystals, has been successfully applied to induce various modifications in the graphene crystal. One of these modifications is the formation of origami like foldings in graphene which are created by swift heavy ion irradiation under glancing incidence angle. These foldings can be applied to locally alter the physical properties of graphene like mechanical strength or chemical reactivity. In this work we show that the formation of foldings in two dimensional crystals is not restricted to graphene but can be applied for other materials like MoS{sub 2} and hexagonal BN as well. Further we show that chemical vapour deposited graphene forms foldings after swift heavy ion irradiation while chemical vapour deposited MoS{sub 2} does not.

  17. Folding two dimensional crystals by swift heavy ion irradiation

    International Nuclear Information System (INIS)

    Ochedowski, Oliver; Bukowska, Hanna; Freire Soler, Victor M.; Brökers, Lara; Ban-d'Etat, Brigitte; Lebius, Henning; Schleberger, Marika


    Ion irradiation of graphene, the showcase model of two dimensional crystals, has been successfully applied to induce various modifications in the graphene crystal. One of these modifications is the formation of origami like foldings in graphene which are created by swift heavy ion irradiation under glancing incidence angle. These foldings can be applied to locally alter the physical properties of graphene like mechanical strength or chemical reactivity. In this work we show that the formation of foldings in two dimensional crystals is not restricted to graphene but can be applied for other materials like MoS 2 and hexagonal BN as well. Further we show that chemical vapour deposited graphene forms foldings after swift heavy ion irradiation while chemical vapour deposited MoS 2 does not

  18. Evidence for multiphase folding of the central Indian Ocean lithosphere

    Digital Repository Service at National Institute of Oceanography (India)

    Krishna, K.S.; Bull, J.M.; Scrutton, R.A.

    Long-wavelength (100-300 km) folding in the central Indian Ocean associated with the diffuse plate boundary separating the Indian, Australian, and Capricorn plates is Earth's most convincing example of organized large-scale lithospheric deformation...

  19. Nonlinear vs. linear biasing in Trp-cage folding simulations

    Energy Technology Data Exchange (ETDEWEB)

    Spiwok, Vojtěch, E-mail:; Oborský, Pavel; Králová, Blanka [Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague, Technická 3, Prague 6 166 28 (Czech Republic); Pazúriková, Jana [Institute of Computer Science, Masaryk University, Botanická 554/68a, 602 00 Brno (Czech Republic); Křenek, Aleš [Institute of Computer Science, Masaryk University, Botanická 554/68a, 602 00 Brno (Czech Republic); Center CERIT-SC, Masaryk Univerzity, Šumavská 416/15, 602 00 Brno (Czech Republic)


    Biased simulations have great potential for the study of slow processes, including protein folding. Atomic motions in molecules are nonlinear, which suggests that simulations with enhanced sampling of collective motions traced by nonlinear dimensionality reduction methods may perform better than linear ones. In this study, we compare an unbiased folding simulation of the Trp-cage miniprotein with metadynamics simulations using both linear (principle component analysis) and nonlinear (Isomap) low dimensional embeddings as collective variables. Folding of the mini-protein was successfully simulated in 200 ns simulation with linear biasing and non-linear motion biasing. The folded state was correctly predicted as the free energy minimum in both simulations. We found that the advantage of linear motion biasing is that it can sample a larger conformational space, whereas the advantage of nonlinear motion biasing lies in slightly better resolution of the resulting free energy surface. In terms of sampling efficiency, both methods are comparable.

  20. Trends in Utilization of Vocal Fold Injection Procedures. (United States)

    Rosow, David E


    Office-based vocal fold injections have become increasingly popular over the past 15 years. Examination of trends in procedure coding for vocal fold injections in the United States from 2000 to 2012 was undertaken to see if they reflect this shift. The US Part B Medicare claims database was queried from 2000 through 2012 for multiple Current Procedural Terminology codes. Over the period studied, the number of nonoperative laryngoscopic injections (31513, 31570) and operative medialization laryngoplasties (31588) remained constant. Operative vocal fold injection (31571) demonstrated marked linear growth over the 12-year study period, from 744 procedures in 2000 to 4788 in 2012-an increase >640%. The dramatic increased incidence in the use of code 31571 reflects an increasing share of vocal fold injections being performed in the operating room and not in an office setting, running counter to the prevailing trend toward awake, office-based injection procedures. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

  1. Traumatic chorioretinal folds treated with intra-vitreal triamcinolone injection

    Directory of Open Access Journals (Sweden)

    Kook Young Kim


    Full Text Available A 34-year-old male visited the hospital due to decreased visual acuity in the left eye following an injury from a car accident. In the left eye, best-corrected visual acuity (BCVA was hand motion and intraocular pressure (IOP was 8 mmHg. Choroidal vasodilation and chorioretinal folds were observed by spectral domain-optical coherence tomography (SD-OCT. Topical and systemic steroid treatments did not improve the chorioretinal folds. Twelve months after the injury, intra-vitreal triamcinolone (4 mg/0.1 ml was injected. Six months after intra-vitreal triamcinolone injection, BCVA in the left eye had improved to 20/100. Fundus examination showed improvement in retinal vascular tortuosity and SD-OCT revealed improvements in choroidal vasodilation and chorioretinal folds. Intra-vitreal triamcinolone injection (IVTI was effective against traumatic chorioretinal folds with no recurrence based on objective observation by fundus photography and SD-OCT.

  2. Phonosurgery of the vocal folds : a classification proposal

    NARCIS (Netherlands)

    Remacle, M; Friedrich, G; Dikkers, FG; de Jong, F

    The Phonosurgery Committee of the European Laryngological Society (ELS) has examined the definition and technical description of phonosurgical procedures. Based on this review, the committee has proposed a working classification. The current presentation is restricted to vocal fold surgery (VFS)

  3. Protein folding and misfolding shining light by infrared spectroscopy

    CERN Document Server

    Fabian, Heinz


    Infrared spectroscopy is a new and innovative technology to study protein folding/misfolding events in the broad arsenal of techniques conventionally used in this field. The progress in understanding protein folding and misfolding is primarily due to the development of biophysical methods which permit to probe conformational changes with high kinetic and structural resolution. The most commonly used approaches rely on rapid mixing methods to initiate the folding event via a sudden change in solvent conditions. Traditionally, techniques such as fluorescence, circular dichroism or visible absorption are applied to probe the process. In contrast to these techniques, infrared spectroscopy came into play only very recently, and the progress made in this field up to date which now permits to probe folding events over the time scale from picoseconds to minutes has not yet been discussed in a book. The aim of this book is to provide an overview of the developments as seen by some of the main contributors to the field...

  4. Thermal analysis for folded solar array of spacecraft in orbit

    International Nuclear Information System (INIS)

    Yang, W.H.; Cheng, H.E.; Cai, A.


    The combined radiation-conduction heat transfer in folded solar array was considered as a three-dimensional anisotropic conduction without inner heat source. The three-dimensional equivalent conductivity in cell plate were obtained. The especially discrete equation coefficients of the nodes on the surfaces of adjacent cell plates were deduced by utilizing the simplified radiation network among the two adjacent cell plate surfaces and the deep cold space. All the thermal influence factors on the temperature response of the folded solar array were considered carefully. SIP method was used to solve the discrete equation. By comparing the calculation results under three cases, the temperature response and the maximum average difference of the folded solar array was obtained during the period of throw-radome of the launch vehicle and spread of the folded solar array. The obtained result is a valuable reference for the selection of the launch time of the spacecraft

  5. Morphometric Study of Vocal Folds in Indian Cadavers

    Directory of Open Access Journals (Sweden)

    Rawal J.D.


    Full Text Available Introduction: -The larynx is an air passage and a sphincteric device used in respiration and phonation. The larynx, from inside outwards has a framework of mucosa surrounded by fibro-elastic membrane which in turn is surrounded by cartilages and then a layer of muscles. Vocal folds are intrinsic ligament of larynx covered by mucosal folds. Larynx generates sound through rhythmic opening and closing of the vocal folds. The perceived pitch of human voice mainly depends upon fundamental frequency of sound generated by larynx. Aim: - The aim of present study is to measure various dimensions of vocal folds in Indian cadavers. Material & Methods: - 50 larynx were obtained from embalmed cadavers, of which 10 larynx were of females. Vocal cords were dissected from the larynx and morphometric analysis was done. Results and Conclusions: - The average total length of the vocal folds was found to be 16.11 mm. ± 2.62 mm. in male and 14.10 mm. ± 1.54 mm. in female cadavers. The average width of the vocal folds was found to be 4.38 mm. ± 0.74 mm. in male and 3.60 mm. ± 0.64 mm. in female cadavers. The average total length of the membranous part of the vocal folds was found to be 11.90 mm. ± 1.86 mm. in male and 10.45 mm. ± 1.81 mm. in female cadavers. The average ratio of the length of the membranous and the cartilaginous parts of the vocal folds was calculated to be 3.10 ± 0.96in male and 2.85 ± 0.73in female cadavers.

  6. WW Domain Folding Complexity Revealed by Infrared Spectroscopy


    Davis, Caitlin M.; Dyer, R. Brian


    Although the intrinsic tryptophan fluorescence of proteins offers a convenient probe of protein folding, interpretation of the fluorescence spectrum is often difficult because it is sensitive to both global and local changes. Infrared (IR) spectroscopy offers a complementary measure of structural changes involved in protein folding, because it probes changes in the secondary structure of the protein backbone. Here we demonstrate the advantages of using multiple probes, infrared and fluorescen...

  7. Cervical osteophytes presenting as unilateral vocal fold paralysis and dysphagia. (United States)

    Yoskovitch, A; Kantor, S


    Any process involving either the vagus nerve, its recurrent laryngeal branch or the external branch of the superior laryngeal nerve may cause paralysis of the vocal fold. The most common cause is neoplasm. Clinically, the patients often present with a hoarse, breathy voice as well as symptoms of aspiration. The following represents a unique case of unilateral vocal fold paralysis and dysphagia caused by a degenerative disease of the cervical spine, resluting in extrinsic compression of the recurrent laryngeal nerve.

  8. Double folded Yukawa interaction potential between two heavy ions

    International Nuclear Information System (INIS)

    Bulgac, A.; Carstoiu, F.; Dumitrescu, O.


    A simple semi-analytical formula for the heavy ion interaction potential within the double-folding model approximation is obtained. The folded interaction is assumed to be expressed in Yukawa terms or the derivatives of them. The densities used can be both experimental or theoretical (of simple ''step-wise'', ''Fermi-Saxon-Woods'' or complicated ''shell model'' structure) densities. A way of inserting the exchange terms is discussed. Numerical calculations for some colliding partners are reported. (author)

  9. The Arterial Folding Point During Flexion of the Hip Joint

    International Nuclear Information System (INIS)

    Park, Sung Il; Won, Je Hwan; Kim, Byung Moon; Kim, Jae Keun; Lee, Do Yun


    Purpose: Endovascular stents placed in periarticular vessels may be at a greater risk of neointimal hyperplasia and eventual occlusion than those placed in non-periarticular vessels. The purpose of this study was to investigate the location of maximal conformational change along the iliac and femoral artery, the folding point, during flexion of the hip joint and its location relative to the hip joint and the inguinal ligament. Methods: Seventy patients undergoing femoral artery catheterization were evaluated. The patients were 47 men and 23 women and ranged in age from 26 to 75 years (mean 54 years). The arteries (right:left = 34:36) were measured using a marked catheter for sizing vessels. Fluoroscopic images were obtained in anteroposterior and lateral projections in neutral position, and in the lateral projection in flexed position of the hip joint. The folding point was determined by comparing the lateral projection images in the neutral and flexed positions. The distance from the acetabular roof to the folding point and the distance from the inguinal ligament to the folding point was evaluated. Results: : The folding point was located 42.8 ± 28.6 mm cranial to the acetabular roof and 35.1 ± 30.1 mm cranial to the inguinal ligament. As the patient’s age increased, the folding point was located more cranially (p < 0.001). Conclusions: The folding point during flexion of the hip joint was located 42.8 ± 28.6 mm cranial to the acetabular roof and 35.1 ± 30.1 mm cranial to the inguinal ligament. As the patient's age increased, the folding point was located more cranially. When a stent is inserted over this region, more attention may be needed during follow-up to monitor possible occlusion and stent failure.

  10. Oral and vocal fold diadochokinesis in dysphonic women


    Louzada,Talita; Beraldinelle,Roberta; Berretin-Felix,Giédre; Brasolotto,Alcione Ghedini


    The evaluation of oral and vocal fold diadochokinesis (DDK) in individuals with voice disorders may contribute to the understanding of factors that affect the balanced vocal production. Scientific studies that make use of this assessment tool support the knowledge advance of this area, reflecting the development of more appropriate therapeutic planning. Objective: To compare the results of oral and vocal fold DDK in dysphonic women and in women without vocal disorders. Material and methods: F...

  11. Vocal fold ion transport and mucin expression following acrolein exposure. (United States)

    Levendoski, Elizabeth Erickson; Sivasankar, M Preeti


    The vocal fold epithelium is exposed to inhaled particulates including pollutants during breathing in everyday environments. Yet, our understanding of the effects of pollutants on vocal fold epithelial function is extremely limited. The objective of this study was to investigate the effect of the pollutant acrolein on two vocal fold epithelial mechanisms: ion transport and mucin (MUC) synthesis. These mechanisms were chosen as each plays a critical role in vocal defense and in maintaining surface hydration which is necessary for optimal voice production. Healthy, native porcine vocal folds (N = 85) were excised and exposed to an acrolein or sham challenge. A 60-min acrolein, but not sham challenge significantly reduced ion transport and inhibited cyclic adenosine monophosphate-dependent, increases in ion transport. Decreases in ion transport were associated with reduced sodium absorption. Within the same timeline, no significant acrolein-induced changes in MUC gene or protein expression were observed. These results improve our understanding of the effects of acrolein on key vocal fold epithelial functions and inform the development of future investigations that seek to elucidate the impact of a wide range of pollutant exposures on vocal fold health.

  12. Protein solubility and folding enhancement by interaction with RNA.

    Directory of Open Access Journals (Sweden)

    Seong Il Choi

    Full Text Available While basic mechanisms of several major molecular chaperones are well understood, this machinery has been known to be involved in folding of only limited number of proteins inside the cells. Here, we report a chaperone type of protein folding facilitated by interaction with RNA. When an RNA-binding module is placed at the N-terminus of aggregation-prone target proteins, this module, upon binding with RNA, further promotes the solubility of passenger proteins, potentially leading to enhancement of proper protein folding. Studies on in vitro refolding in the presence of RNA, coexpression of RNA molecules in vivo and the mutants with impaired RNA binding ability suggests that RNA can exert chaperoning effect on their bound proteins. The results suggest that RNA binding could affect the overall kinetic network of protein folding pathway in favor of productive folding over off-pathway aggregation. In addition, the RNA binding-mediated solubility enhancement is extremely robust for increasing soluble yield of passenger proteins and could be usefully implemented for high-throughput protein expression for functional and structural genomic research initiatives. The RNA-mediated chaperone type presented here would give new insights into de novo folding in vivo.

  13. Self-Folding Textiles through Manipulation of Knit Stitch Architecture

    Directory of Open Access Journals (Sweden)

    Chelsea E. Knittel


    Full Text Available This research presents a preliminary study on finding predictable methods of controlling the self-folding behaviors of weft knit textiles for use in the development of smart textiles and garment devices, such as those with shape memory, auxetic behavior or transformation abilities. In this work, Shima Seiki SDS-One Apex computer-aided knitting technology, Shima Seiki industrial knitting machines, and the study of paper origami tessellation patterns were used as tools to understand and predict the self-folding abilities of weft knit textiles. A wide range of self-folding weft knit structures was produced, and relationships between the angles and ratios of the knit and purl stitch types were determined. Mechanical testing was used as a means to characterize differences produced by stitch patterns, and to further understand the relationships between angles and folding abilities. By defining a formulaic method for predicting the nature of the folds that occur due to stitch architecture patterns, we can better design self-folding fabrics for smart textile applications.

  14. Multi-crease Self-folding by Global Heating. (United States)

    Miyashita, Shuhei; Onal, Cagdas D; Rus, Daniela


    This study demonstrates a new approach to autonomous folding for the body of a 3D robot from a 2D sheet, using heat. We approach this challenge by folding a 0.27-mm sheetlike material into a structure. We utilize the thermal deformation of a contractive sheet sandwiched by rigid structural layers. During this baking process, the heat applied on the entire sheet induces contraction of the contracting layer and thus forms an instructed bend in the sheet. To attain the targeted folding angles, the V-fold spans method is used. The targeted angle θout can be kinematically encoded into crease geometry. The realization of this angle in the folded structure can be approximately controlled by a contraction angle θin. The process is non-reversible, is reliable, and is relatively fast. Our method can be applied simultaneously to all the folds in multi-crease origami structures. We demonstrate the use of this method to create a lightweight mobile robot.

  15. Synthetic oligorotaxanes exert high forces when folding under mechanical load (United States)

    Sluysmans, Damien; Hubert, Sandrine; Bruns, Carson J.; Zhu, Zhixue; Stoddart, J. Fraser; Duwez, Anne-Sophie


    Folding is a ubiquitous process that nature uses to control the conformations of its molecular machines, allowing them to perform chemical and mechanical tasks. Over the years, chemists have synthesized foldamers that adopt well-defined and stable folded architectures, mimicking the control expressed by natural systems1,2. Mechanically interlocked molecules, such as rotaxanes and catenanes, are prototypical molecular machines that enable the controlled movement and positioning of their component parts3-5. Recently, combining the exquisite complexity of these two classes of molecules, donor-acceptor oligorotaxane foldamers have been synthesized, in which interactions between the mechanically interlocked component parts dictate the single-molecule assembly into a folded secondary structure6-8. Here we report on the mechanochemical properties of these molecules. We use atomic force microscopy-based single-molecule force spectroscopy to mechanically unfold oligorotaxanes, made of oligomeric dumbbells incorporating 1,5-dioxynaphthalene units encircled by cyclobis(paraquat-p-phenylene) rings. Real-time capture of fluctuations between unfolded and folded states reveals that the molecules exert forces of up to 50 pN against a mechanical load of up to 150 pN, and displays transition times of less than 10 μs. While the folding is at least as fast as that observed in proteins, it is remarkably more robust, thanks to the mechanically interlocked structure. Our results show that synthetic oligorotaxanes have the potential to exceed the performance of natural folding proteins.

  16. Synchrotron-based P K-edge XANES spectroscopy reveals rapid changes of phosphorus speciation in the topsoil of two glacier foreland chronosequences (United States)

    Prietzel, Jörg; Dümig, Alexander; Wu, Yanhong; Zhou, Jun; Klysubun, Wantana


    Phosphorus (P) is a crucial element for life on Earth, and the bioavailability of P in terrestrial ecosystems, which is dependent on the soil P stock and its speciation, may limit ecosystem productivity and succession. In our study, for the first time a direct speciation of soil P in two glacier foreland chronosequences has been conducted using synchrotron-based X-ray Absorption Near-Edge Structure (XANES) spectroscopy. The chronosequences are located in the forefields of Hailuogou Glacier (Gongga Shan, China) and Damma Glacier (Swiss Alps). The age since deglaciation of the investigated soils ranges from 0 to 120 years at Hailuogou, and from 15 to >700 years at Damma. Differences in climate conditions (cooler at Damma, in contrast to Hailuogou precluding the establishment of forest in advanced ecosystem succession stages) and in the chemical composition of the parent material result in different soil contents of total P and Fe/Al oxyhydroxides, which are much smaller at Damma than at Hailuogou. Nevertheless, both chronosequences show similar trends of their topsoil P status with increasing soil age. Our study reveals a rapid change of topsoil P speciation in glacier retreat areas already during initial stages of pedogenesis: Initially dominating bedrock-derived apatite-P and Al-bound P is depleted; Fe-bound P and particularly organically-bound P is accumulated. Organic P strongly dominates in the topsoil of the mature soils outside the proglacial area of Damma Glacier (age 700-3000 years), and already 50 years after deglacation in the topsoil of the retreat area of Hailuogou Glacier. A key factor for the change in topsoil P speciation is the establishment of vegetation, resulting in soil organic matter (SOM) accumulation as well as accelerated soil acidification and apatite dissolution by organic acids, which are produced by SOM-degrading micro-organisms, mykorrhiza fungi, and plant roots. Particularly the succession of grassland to forest seems to accelerate the

  17. RNA folding kinetics using Monte Carlo and Gillespie algorithms. (United States)

    Clote, Peter; Bayegan, Amir H


    RNA secondary structure folding kinetics is known to be important for the biological function of certain processes, such as the hok/sok system in E. coli. Although linear algebra provides an exact computational solution of secondary structure folding kinetics with respect to the Turner energy model for tiny ([Formula: see text]20 nt) RNA sequences, the folding kinetics for larger sequences can only be approximated by binning structures into macrostates in a coarse-grained model, or by repeatedly simulating secondary structure folding with either the Monte Carlo algorithm or the Gillespie algorithm. Here we investigate the relation between the Monte Carlo algorithm and the Gillespie algorithm. We prove that asymptotically, the expected time for a K-step trajectory of the Monte Carlo algorithm is equal to [Formula: see text] times that of the Gillespie algorithm, where [Formula: see text] denotes the Boltzmann expected network degree. If the network is regular (i.e. every node has the same degree), then the mean first passage time (MFPT) computed by the Monte Carlo algorithm is equal to MFPT computed by the Gillespie algorithm multiplied by [Formula: see text]; however, this is not true for non-regular networks. In particular, RNA secondary structure folding kinetics, as computed by the Monte Carlo algorithm, is not equal to the folding kinetics, as computed by the Gillespie algorithm, although the mean first passage times are roughly correlated. Simulation software for RNA secondary structure folding according to the Monte Carlo and Gillespie algorithms is publicly available, as is our software to compute the expected degree of the network of secondary structures of a given RNA sequence-see .

  18. Visualization of protein folding funnels in lattice models.

    Directory of Open Access Journals (Sweden)

    Antonio B Oliveira

    Full Text Available Protein folding occurs in a very high dimensional phase space with an exponentially large number of states, and according to the energy landscape theory it exhibits a topology resembling a funnel. In this statistical approach, the folding mechanism is unveiled by describing the local minima in an effective one-dimensional representation. Other approaches based on potential energy landscapes address the hierarchical structure of local energy minima through disconnectivity graphs. In this paper, we introduce a metric to describe the distance between any two conformations, which also allows us to go beyond the one-dimensional representation and visualize the folding funnel in 2D and 3D. In this way it is possible to assess the folding process in detail, e.g., by identifying the connectivity between conformations and establishing the paths to reach the native state, in addition to regions where trapping may occur. Unlike the disconnectivity maps method, which is based on the kinetic connections between states, our methodology is based on structural similarities inferred from the new metric. The method was developed in a 27-mer protein lattice model, folded into a 3×3×3 cube. Five sequences were studied and distinct funnels were generated in an analysis restricted to conformations from the transition-state to the native configuration. Consistent with the expected results from the energy landscape theory, folding routes can be visualized to probe different regions of the phase space, as well as determine the difficulty in folding of the distinct sequences. Changes in the landscape due to mutations were visualized, with the comparison between wild and mutated local minima in a single map, which serves to identify different trapping regions. The extension of this approach to more realistic models and its use in combination with other approaches are discussed.

  19. Solitons and protein folding: An In Silico experiment

    International Nuclear Information System (INIS)

    Ilieva, N.; Dai, J.; Sieradzan, A.; Niemi, A.


    Protein folding [1] is the process of formation of a functional 3D structure from a random coil — the shape in which amino-acid chains leave the ribosome. Anfinsen’s dogma states that the native 3D shape of a protein is completely determined by protein’s amino acid sequence. Despite the progress in understanding the process rate and the success in folding prediction for some small proteins, with presently available physics-based methods it is not yet possible to reliably deduce the shape of a biologically active protein from its amino acid sequence. The protein-folding problem endures as one of the most important unresolved problems in science; it addresses the origin of life itself. Furthermore, a wrong fold is a common cause for a protein to lose its function or even endanger the living organism. Soliton solutions of a generalized discrete non-linear Schrödinger equation (GDNLSE) obtained from the energy function in terms of bond and torsion angles κ and τ provide a constructive theoretical framework for describing protein folds and folding patterns [2]. Here we study the dynamics of this process by means of molecular-dynamics simulations. The soliton manifestation is the pattern helix–loop–helix in the secondary structure of the protein, which explains the importance of understanding loop formation in helical proteins. We performed in silico experiments for unfolding one subunit of the core structure of gp41 from the HIV envelope glycoprotein (PDB ID: 1AIK [3]) by molecular-dynamics simulations with the MD package GROMACS. We analyzed 80 ns trajectories, obtained with one united-atom and two different all-atom force fields, to justify the side-chain orientation quantification scheme adopted in the studies and to eliminate force-field based artifacts. Our results are compatible with the soliton model of protein folding and provide first insight into soliton-formation dynamics

  20. Solitons and protein folding: An In Silico experiment

    Energy Technology Data Exchange (ETDEWEB)

    Ilieva, N., E-mail: [Institute of Information and Communication Technologies, Bulgarian Aacademy of Sciences, Sofia (Bulgaria); Dai, J., E-mail: [School of Physics, Beijing Institute of Technology, Beijing (China); Sieradzan, A., E-mail: [Faculty of Chemistry, University of Gdańsk, Gdańsk (Poland); Niemi, A., E-mail: [Department of Physics and Astronomy, Uppsala University, Uppsala (Sweden); LMPT–CNRS, Université de Tours, Tours (France)


    Protein folding [1] is the process of formation of a functional 3D structure from a random coil — the shape in which amino-acid chains leave the ribosome. Anfinsen’s dogma states that the native 3D shape of a protein is completely determined by protein’s amino acid sequence. Despite the progress in understanding the process rate and the success in folding prediction for some small proteins, with presently available physics-based methods it is not yet possible to reliably deduce the shape of a biologically active protein from its amino acid sequence. The protein-folding problem endures as one of the most important unresolved problems in science; it addresses the origin of life itself. Furthermore, a wrong fold is a common cause for a protein to lose its function or even endanger the living organism. Soliton solutions of a generalized discrete non-linear Schrödinger equation (GDNLSE) obtained from the energy function in terms of bond and torsion angles κ and τ provide a constructive theoretical framework for describing protein folds and folding patterns [2]. Here we study the dynamics of this process by means of molecular-dynamics simulations. The soliton manifestation is the pattern helix–loop–helix in the secondary structure of the protein, which explains the importance of understanding loop formation in helical proteins. We performed in silico experiments for unfolding one subunit of the core structure of gp41 from the HIV envelope glycoprotein (PDB ID: 1AIK [3]) by molecular-dynamics simulations with the MD package GROMACS. We analyzed 80 ns trajectories, obtained with one united-atom and two different all-atom force fields, to justify the side-chain orientation quantification scheme adopted in the studies and to eliminate force-field based artifacts. Our results are compatible with the soliton model of protein folding and provide first insight into soliton-formation dynamics.

  1. The nature of folded states of globular proteins. (United States)

    Honeycutt, J D; Thirumalai, D


    We suggest, using dynamical simulations of a simple heteropolymer modelling the alpha-carbon sequence in a protein, that generically the folded states of globular proteins correspond to statistically well-defined metastable states. This hypothesis, called the metastability hypothesis, states that there are several free energy minima separated by barriers of various heights such that the folded conformations of a polypeptide chain in each of the minima have similar structural characteristics but have different energies from one another. The calculated structural characteristics, such as bond angle and dihedral angle distribution functions, are assumed to arise from only those configurations belonging to a given minimum. The validity of this hypothesis is illustrated by simulations of a continuum model of a heteropolymer whose low temperature state is a well-defined beta-barrel structure. The simulations were done using a molecular dynamics algorithm (referred to as the "noisy" molecular dynamics method) containing both friction and noise terms. It is shown that for this model there are several distinct metastable minima in which the structural features are similar. Several new methods of analyzing fluctuations in structures belonging to two distinct minima are introduced. The most notable one is a dynamic measure of compactness that can in principle provide the time required for maximal compactness to be achieved. The analysis shows that for a given metastable state in which the protein has a well-defined folded structure the transition to a state of higher compactness occurs very slowly, lending credence to the notion that the system encounters a late barrier in the process of folding to the most compact structure. The examination of the fluctuations in the structures near the unfolding----folding transition temperature indicates that the transition state for the unfolding to folding process occurs closer to the folded state.

  2. Active tectonics and Holocene versus modern catchment erosion rates at 300 MW Baspa II hydroelectric power plant (NW Himalaya, India) (United States)

    Draganits, Erich; Grasemann, Bernhard; Gier, Susanne; Hofmann, Christa-Charlotte; Janda, Christoph; Bookhagen, Bodo; Preh, Alexander


    The Baspa River is one of the most important tributaries to the Sutlej River in the NW Himalaya (India). Its catchment is 1116 km2 in size, ranges from c. 6400 m asl to 1770 m asl and contains India's largest private hydroelectric facility, the 300 MW Baspa II. Geologically, the hydroelectric installation is located in the Higher Himalayan Crystalline, just above the active Karcham Normal Fault, which is reactivating the Early Miocene Main Central Thrust, one of the principal Himalayan faults. The area is seismically active and mass-movements are common. Around 8200 yrs BP the Baspa was dammed by a rock-avalanche dam, leading to the formation of the originally c. 260 m deep palaeo-lake Sangla palaeo-lake. Detailed sedimentological investigations and radiocarbon dating indicate that the palaeo-lake was completely filled with sediments until c. 5100 yrs BP. This makes the Sangla palaeo-lake to a very rare example of a mass-movement dam with very long duration and its lacustrine sediments represent a valuable archive for geological processes and environmental proxies within the Baspa catchment during the c. 3100 years of its existence - which are the aim of our study. At least 5 levels of soft-sediment deformation have been recorded in the exposed part of the lacustrine sediments of Sangla palaeo-lake, including brecciated laminae, overturned laminae, folds, faults and deformation bands, separated by undeformed deposits. They are interpreted as seismites, indicating at least 5 earthquakes within 2500 years strong enough to cause liquefaction. The 300 MW Baspa II hydro-electric power plant has been built exactly on top of this palaeo-lake. This special location represents a very rare possibility to evaluate the short-term, river load and hydrological parameters measured during the planning and operational stages of Baspa II with the long-term parameters gained from the palaeo-lake sediments from the catchment. This data show that the Mid-Holocene erosion rates of the

  3. Tectonic implications of U-Pb (zircon) Geochronology of Chor Granitoids of the Lesser Himalaya, Himachal Pradesh, NW Himalaya (United States)

    Singh, P.; Bhakuni, S. S.


    Granitoids of various ages ranging from Proterozoic to Tertiary occur throughout the Himalayan fold-thrust belt. The occurrence of the Neoproterozoic granitoids are very less in the Himalayan orogen. One of the best example of Neoproterozoic granitoids is Chor granitoids, which are the intrusive granite bodies in the Paleoproterozoic of the Lesser Himalayan Crystallines of the Jutogh Group. In the central part these granites are non-foliated homogeneous that are porphyritic and peraluminous in nature (Singh et al., 2002; Bhargava et al., 2014, 2016), whereas in the peripheral part these are foliated showing south directed shear sense of movement. In this work we present the U-Pb (zircon) geochronology of two different granites samples of the Chor granitoids of Himachal Pradesh, NW Himalaya. The Jutogh Group of rocks is thrust over the Lesser Himalayan Sequence along the Jutogh Thrust or MCT. The geochronology of the Chor Granitoids and Lesser Himalayan Crystallines and their relationship with each other, including with the Indian shield are sparsely obscure. U-Pb zircon geochrnological age populations from these granitoids yield ages between 780 and 980 Ma. One sample gives the prominent age spectra for 206Pb/238U with weighted mean age of 908.3 ± 6.7 Ma (2σ) MSWD = 2.4 (n = 18). Similarly another sample gives the age of crystallization with weight mean age of 917 ± 17 Ma (2σ) MSWD = 3 (n = 11) and Th/U ratios of both samples are >0.1, indicating their magmatic origin. As a result of ductile shearing of granites along the MCT during the Cenozoic Himalayan Orogeny, the age has reduced to 780 Ma. The Neoproterozoic age of Chor granite matches with the Neoproterozoic detrital zircon age (800 to 1000 Ma by Parrish and Hodges 1996, Decelles et al., 2000) of the HHC. On the basis of U-Pb (zircon) geochronological ages, it is revealed that the source of zircons of the Chor granite and HHC rocks was the northern margin of the Pan-African orogen. The Chor granitoids was

  4. Vocal Fold Injection: Review of Indications, Techniques, and Materials for Augmentation


    Mallur, Pavan S.; Rosen, Clark A.


    Vocal fold injection is a procedure that has over a 100 year history but was rarely done as short as 20 years ago. A renaissance has occurred with respect to vocal fold injection due to new technologies (visualization and materials) and new injection approaches. Awake, un-sedated vocal fold injection offers many distinct advantages for the treatment of glottal insufficiency (vocal fold paralysis, vocal fold paresis, vocal fold atrophy and vocal fold scar). A review of materials available and ...

  5. WW domain folding complexity revealed by infrared spectroscopy. (United States)

    Davis, Caitlin M; Dyer, R Brian


    Although the intrinsic tryptophan fluorescence of proteins offers a convenient probe of protein folding, interpretation of the fluorescence spectrum is often difficult because it is sensitive to both global and local changes. Infrared (IR) spectroscopy offers a complementary measure of structural changes involved in protein folding, because it probes changes in the secondary structure of the protein backbone. Here we demonstrate the advantages of using multiple probes, infrared and fluorescence spectroscopy, to study the folding of the FBP28 WW domain. Laser-induced temperature jumps coupled with fluorescence or infrared spectroscopy have been used to probe changes in the peptide backbone on the submillisecond time scale. The relaxation dynamics of the β-sheets and β-turn were measured independently by probing the corresponding IR bands assigned in the amide I region. Using these wavelength-dependent measurements, we observe three kinetics phases, with the fastest process corresponding to the relaxation kinetics of the turns. In contrast, fluorescence measurements of the wild-type WW domain and tryptophan mutants exhibit single-exponential kinetics with a lifetime that corresponds to the slowest phase observed by infrared spectroscopy. Mutant sequences provide evidence of an intermediate dry molten globule state. The slowest step in the folding of this WW domain is the tight packing of the side chains in the transition from the dry molten globule intermediate to the native structure. This study demonstrates that using multiple complementary probes enhances the interpretation of protein folding dynamics.

  6. Intermediates and the folding of proteins L and G

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Scott; Head-Gordon, Teresa


    We use a minimalist protein model, in combination with a sequence design strategy, to determine differences in primary structure for proteins L and G that are responsible for the two proteins folding through distinctly different folding mechanisms. We find that the folding of proteins L and G are consistent with a nucleation-condensation mechanism, each of which is described as helix-assisted {beta}-1 and {beta}-2 hairpin formation, respectively. We determine that the model for protein G exhibits an early intermediate that precedes the rate-limiting barrier of folding and which draws together misaligned secondary structure elements that are stabilized by hydrophobic core contacts involving the third {beta}-strand, and presages the later transition state in which the correct strand alignment of these same secondary structure elements is restored. Finally the validity of the targeted intermediate ensemble for protein G was analyzed by fitting the kinetic data to a two-step first order reversible reaction, proving that protein G folding involves an on-pathway early intermediate, and should be populated and therefore observable by experiment.

  7. Fold maps and positive topological quantum field theories

    Energy Technology Data Exchange (ETDEWEB)

    Wrazidlo, Dominik Johannes


    The notion of positive TFT as coined by Banagl is specified by an axiomatic system based on Atiyah's original axioms for TFTs. By virtue of a general framework that is based on the concept of Eilenberg completeness of semirings from computer science, a positive TFT can be produced rigorously via quantization of systems of fields and action functionals - a process inspired by Feynman's path integral from classical quantum field theory. The purpose of the present dissertation thesis is to investigate a new differential topological invariant for smooth manifolds that arises as the state sum of the fold map TFT, which has been constructed by Banagl as a example of a positive TFT. By eliminating an internal technical assumption on the fields of the fold map TFT, we are able to express the informational content of the state sum in terms of an extension problem for fold maps from cobordisms into the plane. Next, we use the general theory of generic smooth maps into the plane to improve known results about the structure of the state sum in arbitrary dimensions, and to determine it completely in dimension two. The aggregate invariant of a homotopy sphere, which is derived from the state sum, naturally leads us to define a filtration of the group of homotopy spheres in order to understand the role of indefinite fold lines beyond a theorem of Saeki. As an application, we show how Kervaire spheres can be characterized by indefinite fold lines in certain dimensions.


    Directory of Open Access Journals (Sweden)

    Chang Patricia


    Full Text Available Background: The proximal fold is an important part of the nail apparatus it contributes to the formation of the nail plate and through the cuticle acts as an impermeable barrier protecting it from any cause.Objective: To know the proximal nail fold hematoma caused by the use of pulse oximeter.Material and Methods: A descriptive study was conducted in 41 patients with proximal nail hematoma secondary to the use of oximetry in patients hospitalized in the Intermediate and Intensive Care Unit at the Hospital General de Enfermedades from December 1, 2007 to December 31, 2010.Results: We studied 41 patients with proximal nail fold hematoma secondary to the use of oximeter, 30 (73.1% were males and 11 (26.8% females. The numbers of fingers affected by pulse oximeter were in one digit. 30 (73.1% cases, in two digits 6 (14.6%, in three digits 3 (7.3%, in 4 digits 1 (2.4% and in 5 digits 1 (2.4% case. The most affected proximal nail fold was right index: 24 (58.5%, right middle 11 (26.8%, right ring 6 (14.6%, left index 12 (29.2%, and left middle 6 (14.6% cases.Conclusions: Hematomas of the proximal nail fold may be caused by different traumatisms. The use of pulse oximeter is one of them.

  9. Recurrence of vocal fold leukoplakia after carbon dioxide laser therapy. (United States)

    Chen, Min; Chen, Jian; Cheng, Lei; Wu, Haitao


    This work aims to analyze the recurrence of vocal fold leukoplakia after carbon dioxide (CO 2 ) laser resection. In this retrospective study, all patients undergoing CO 2 laser resection of vocal fold leukoplakia were followed up for at least 2 years. Recurrence was diagnosed as any presence of leukoplakia in the vocal cord subsequent to previous successful complete resection. A total of 326 patients with complete resection of vocal fold leukoplakia and follow-up subsequent surveillance laryngoscopy were studied. The recurrence rate, the recurrence time, and risk factors were evaluated. Of these, 52 (16.0%) patients experienced recurrence with a mean follow-up time of 50.5 ± 15.4 months. The mean time to recurrence was 16.2 ± 14.1 months. Univariate analysis showed that the size of lesion (P vocal fold leukoplakia, long-term follow-up is required after CO 2 laser resection. In conclusion, the size of lesion combined with the pathological grade are important risk factors that predict vocal fold leukoplakia recurrence.

  10. Possible association between Helicobacter pylori infection and vocal fold leukoplakia. (United States)

    Chen, Min; Chen, Jian; Yang, Yue; Cheng, Lei; Wu, Hai-Tao


    Several studies have indicated the larynx as possible Helicobacter pylori (H. pylori) reservoirs. This study explored the association between H. pylori and vocal fold leukoplakia. The case-control study involved 51 patients with vocal fold leukoplakia and 35 control patients with vocal polyps. Helicobacter pylori was detected in tissues by the rapid urease test, nested polymerase chain reaction (PCR), and single-step PCR. The H. pylori-specific immunoglobulin antibodies were detected in plasma by enzyme-linked immunosorbent assay (ELISA). Helicobacter pylori-positive rate of vocal fold leukoplakia and vocal polyps was 23.5% versus 11.4% (P = .157), 37.2% versus 14.3% (P = .020), 27.5% versus 8.6% (P = .031), and 70.6% versus 68.6% (P = .841) detected by rapid urease test, nested PCR, single-step PCR, and ELISA, respectively. Regression analysis indicated that H. pylori infection (P = .044) was the independent risk factor for vocal fold leukoplakia. Helicobacter pylori infection exists in the larynx and may be associated with vocal fold leukoplakia. © 2018 Wiley Periodicals, Inc.

  11. Sulfated glycosaminoglycans in human vocal fold lamina propria

    Directory of Open Access Journals (Sweden)

    Sung Woo Park

    Full Text Available Abstract Introduction: The distribution, concentration and function of glycosaminoglycans in the various vocal fold tissues are still unclear. Objective: To evaluate the distribution and concentration of sulfated glycosaminoglycans in different layers of the human vocal fold according to gender and age. Methods: We used 11 vocal folds obtained from cadavers (7 men and 4 women with no laryngeal lesion, less than 12 h after death, and aged between 35 and 98 years. The folds underwent glycosaminoglycans extraction from the cover and ligament, and post-electrophoresis analysis. Data were compared according to the layer, age and gender. Results: The concentration of dermatan sulfate was significantly higher in all layers. No differences were observed in the total concentrations of glycosaminoglycans in layers studied according to gender. It is significantly lower in the cover of individuals aged below 60 years. Conclusion: Dermatan sulfate, chondroitin sulfate, and heparan sulfate were observed in the human vocal folds cover and ligament of both genders, with the concentration of dermatan sulfate being significantly higher in all layers. Glycosaminoglycans concentration on the cover is significantly lower in individuals below 60 years compared with elderly.

  12. Modeling Vocal Fold Intravascular Flow using Synthetic Replicas (United States)

    Terry, Aaron D.; Ricks, Matthew T.; Thomson, Scott L.


    Vocal fold vibration that is induced by air flowing from the lungs is believed to decrease blood flow through the vocal folds. This is important due to the critical role of blood flow in maintaining tissue health. However, the precise mechanical relationships between vocal fold vibration and blood perfusion remain understudied. A platform for studying liquid perfusion in a synthetic, life-size, self-oscillating vocal fold replica has recently been developed. The replicas are fabricated using molded silicone with material properties comparable to those of human vocal fold tissues and that include embedded microchannels through which liquid is perfused. The replicas are mounted on an air flow supply tube to initiate flow-induced vibration. A liquid reservoir is attached to the microchannel to cause liquid to perfuse through replica in the anterior-posterior direction. As replica vibration is initiated and amplitude increases, perfusion flow rate decreases. In this presentation, the replica design will be presented, along with data quantifying the relationships between parameters such as replica vibration amplitude, stiffness, microchannel diameter, and perfusion flow rate. This work was supported by Grant NIDCD R01DC005788 from the National Institutes of Health.

  13. Recovery of Vocal Fold Epithelium after Acute Phonotrauma. (United States)

    Rousseau, Bernard; Kojima, Tsuyoshi; Novaleski, Carolyn K; Kimball, Emily E; Valenzuela, Carla V; Mizuta, Masanobu; Daniero, James J; Garrett, C Gaelyn; Sivasankar, M Preeti


    We investigated the timeline of tissue repair of vocal fold epithelium after acute vibration exposure using an in vivo rabbit model. Sixty-five New Zealand white breeder rabbits were randomized to 120 min of modal- or raised-intensity phonation. After the larynges were harvested at 0, 4, 8, and 24 h, and at 3 and 7 days, the vocal fold tissue was evaluated using electron microscopy and quantitative real-time polymerase chain reaction. There was an immediate decrease in the microprojection depth and height following raised-intensity phonation, paired with upregulation of cyclooxygenase-2. This initial 24-h period was also characterized by the significant downregulation of junction proteins. Interleukin 1β and transforming growth factor β1 were upregulated for 3 and 7 days, respectively, followed by an increase in epithelial cell surface depth at 3 and 7 days. These data appear to demonstrate a shift from inflammatory response to the initiation of a restorative process in the vocal fold epithelium between 24 h and 3 days. Despite the initial damage from raised-intensity phonation, the vocal fold epithelium demonstrates a remarkable capacity for the expeditious recovery of structural changes from transient episodes of acute phonotrauma. While structurally intact, the return of functional barrier integrity may be delayed by repeated episodes of phonotrauma and may also play an important role in the pathophysiology of vocal fold lesions. © 2017 S. Karger AG, Basel.

  14. Bilateral Vocal Fold Medialization: A Treatment for Abductor Spasmodic Dysphonia. (United States)

    Dewan, Karuna; Berke, Gerald S


    Abductor spasmodic dysphonia, a difficult-to-treat laryngologic condition, is characterized by spasms causing the vocal folds to remain abducted despite efforts to adduct them during phonation. Traditional treatment for abductor spasmodic dysphonia-botulinum toxin injection into the posterior cricoarytenoid muscle-can be both technically challenging and uncomfortable. Due to the difficulty of needle placement, it is often unsuccessful. The purpose of this investigation is to present a previously undescribed treatment for abductor spasmodic dysphonia-bilateral vocal fold medialization. A retrospective case review of all cases of abductor spasmodic dysphonia treated in a tertiary care laryngology practice with bilateral vocal fold medialization over a 10-year period was performed. The Voice Handicap Index and the Voice-Related Quality of Life surveys were utilized to assess patient satisfaction with voice outcome. Six patients with abductor spasmodic dysphonia treated with bilateral vocal fold medialization were identified. Disease severity ranged from mild to severe. All six patients reported statistically significant improvement in nearly all Voice Handicap Index and Voice-Related Quality of Life parameters. They reported fewer voice breaks and greater ease of communication. Results were noted immediately and symptoms continue to be well controlled for many years following medialization. Bilateral vocal fold medialization is a safe and effective treatment for abductor spasmodic dysphonia. It is performed under local anesthesia and provides phonation improvement in the short and long term. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  15. Probabilistic analysis for identifying the driving force of protein folding (United States)

    Tokunaga, Yoshihiko; Yamamori, Yu; Matubayasi, Nobuyuki


    Toward identifying the driving force of protein folding, energetics was analyzed in water for Trp-cage (20 residues), protein G (56 residues), and ubiquitin (76 residues) at their native (folded) and heat-denatured (unfolded) states. All-atom molecular dynamics simulation was conducted, and the hydration effect was quantified by the solvation free energy. The free-energy calculation was done by employing the solution theory in the energy representation, and it was seen that the sum of the protein intramolecular (structural) energy and the solvation free energy is more favorable for a folded structure than for an unfolded one generated by heat. Probabilistic arguments were then developed to determine which of the electrostatic, van der Waals, and excluded-volume components of the interactions in the protein-water system governs the relative stabilities between the folded and unfolded structures. It was found that the electrostatic interaction does not correspond to the preference order of the two structures. The van der Waals and excluded-volume components were shown, on the other hand, to provide the right order of preference at probabilities of almost unity, and it is argued that a useful modeling of protein folding is possible on the basis of the excluded-volume effect.

  16. Microseismicity, tectonics and seismic potential in the Western Himalayan segment, NW Himalaya, India (United States)

    Parija, Mahesh Prasad; Kumar, Sushil; Tiwari, V. M.; Rao, N. Purnachandra; Kumar, Narendra; Biswal, Shubhasmita; Singh, Ishwar


    The tectonics and seismic potential of the western Himalayan segment (30-33°N; 76-80°E) of the NW Himalayan (India) region have been determined in this study. 423 earthquakes were located in the NW Himalaya between 2004 and 2013 using more than 4495 P and 4453 S differential travel times to determine the moment tensors for 8 (Mw ≥ 4.0) of these earthquakes using their broadband regional waveforms. The geometry of the Main Himalayan Thrust (MHT) plane which varies along the strike of the Himalaya in flat and ramp segments with a dip ranging between ∼2.5 to ∼4° to ∼19° below the Himalayan Frontal Thrust (HFT) in the south to the South Tibetan Detachment (STD) in the north has also been deduced in this study. Two crustal ramps were reported in this study with a depth variance below the Main Central Thrust (MCT) and to the South Tibetan Detachment (STD) between 12 to 22 km and 28 to 40 km depth respectively. The estimated earthquake potential prevailing in the western Himalayan seismic gap lying between the epicentral zone of the 1905 Kangra earthquake and the 1975 Kinnaur earthquake reveals that the total amount of energy released since the last great event is only a fraction (3-5%) of the accommodated energy i.e.1.1E+28 dyne-cm/yr. This suggests that if an earthquake hits this NW Himalayan segment in the future, its magnitude might be around Mw ≥ 8.0.

  17. Tectonic-sedimentary evolution of foreland basins: U-Pb dating of the discharge that would have originated the piggy-back basin of Rodeo-Iglesias, San Juan-Argentina

    International Nuclear Information System (INIS)

    Santos, Romulo Duarte Moreira dos; Hauser, Natalia; Matteini, Massimo; Pimentel, Marcio Martins


    Between the 28 ° and 31 ° LS parallels of the Argentinean west, in the province of San Juan, foreland basins originated by the subhorizontal subduction of oceanic crust as a result of the Andean orogeny in the late Oligocene emerges. The Bermejo basin and Rodeo-Iglesias piggy-back basin would be associated with the progressive development of landslides, backscatter and minor faults, and basin fragmentation. Two samples of volcanic rocks, R-1 (rhyolitic dome) and R-3 (fall deposit) of the Rodeo-Iglesias basin, had ages of 8.2 ± 0.11 Ma and 8.7 ± 0.24 Ma. At the same time, the age of the (R-1) made it possible to infer quantitatively the age of the first cavalcade that occurred approximately 8.2 ± 0.11 Ma. From the data obtained in the Rodeo-Iglesias basin both volcanism and the first cavalcade could have been synchronous

  18. RNAslider: a faster engine for consecutive windows folding and its application to the analysis of genomic folding asymmetry

    Directory of Open Access Journals (Sweden)

    Ziv-Ukelson Michal


    Full Text Available Abstract Background Scanning large genomes with a sliding window in search of locally stable RNA structures is a well motivated problem in bioinformatics. Given a predefined window size L and an RNA sequence S of size N (L 3 by applying any of the classical cubic-time RNA folding algorithms to each of the N-L windows of size L. Recently an O(NL2 solution for this problem has been described. Results Here, we describe and implement an O(NLψ(L engine for the consecutive windows folding problem, where ψ(L is shown to converge to O(1 under the assumption of a standard probabilistic polymer folding model, yielding an O(L speedup which is experimentally confirmed. Using this tool, we note an intriguing directionality (5'-3' vs. 3'-5' folding bias, i.e. that the minimal free energy (MFE of folding is higher in the native direction of the DNA than in the reverse direction of various genomic regions in several organisms including regions of the genomes that do not encode proteins or ncRNA. This bias largely emerges from the genomic dinucleotide bias which affects the MFE, however we see some variations in the folding bias in the different genomic regions when normalized to the dinucleotide bias. We also present results from calculating the MFE landscape of a mouse chromosome 1, characterizing the MFE of the long ncRNA molecules that reside in this chromosome. Conclusion The efficient consecutive windows folding engine described in this paper allows for genome wide scans for ncRNA molecules as well as large-scale statistics. This is implemented here as a software tool, called RNAslider, and applied to the scanning of long chromosomes, leading to the observation of features that are visible only on a large scale.

  19. Composition of the metazooplankton community and structure across the continental shelf off tropical NW Australia

    DEFF Research Database (Denmark)

    Jaspers, Cornelia; Nielsen, Torkel Gissel; Maar, Marie

    This talk focuses on the distribution pattern and grazing impact of different functional metazooplankton groups in a tropical marine ecosystem. We studied the metazooplankton distribution across the continental shelf from eutrophic mangrove areas to the oligotrophic deep blue ocean off NW Australia....... Chlorophyll a concentrations were reduced by factor 10 along the transect including a shift towards small sized primary producers. The metazooplankton biomass followed the same pattern. Even though low in abundance, copepods were most frequent followed by larvaceans, doliolids other thaliacea and chaetognaths...

  20. ‘In Drag’: Performativity and Authenticity in Zadie Smith’s NW

    Directory of Open Access Journals (Sweden)

    Zapata Beatriz Pérez


    Full Text Available Zadie Smith’s latest novel, NW, presents a multiverse in which multiplicity is driven into homogeneization by the forces of those dominant discourses that attempt to suppress the category of the “Other.” This paper focuses on the development of the two female protagonists. Their opposing attitudes towards motherhood, together with their confrontation with their origins, bring to the fore the performativity found in the discourses of gender, sexuality, class, and race. Thus, this paper will explore authenticity and performativity in a contemporary context, where patriarchal and neocolonial discourses still apply.

  1. Upper Permian ostracode assemblage from the Jadar Block (Vardar zone, NW Serbia

    Directory of Open Access Journals (Sweden)

    Crasquin Sylvie


    Full Text Available Ostracodes from the Changhsingian (latest Permian age in the uppermost part of the “Bituminous Limestone” Formation of the Komirić Section in NW Serbia (Jadar Block, Vardar Zone are described and illustrated. Three new species of ostracodes are introduced: Basslerella jadarensis n. sp., Acratia serbianella n. sp., and Knoxiella vardarensis n. sp. The ostracode assemblage, together with conodonts and foraminifers, is the first record of the youngest Late Permian age microfaunas from Serbia and from the central part of the Balkan Peninsula.

  2. The use of folding structures in fusion reactors

    International Nuclear Information System (INIS)

    Haines, T.


    Folding structures can be used with advantage in fusion machines. They have been used in Space for decades to extend antennas, sensors and solar panels; terrestrial versions have been used as retractable antennas and antennas masts. They have also been used in the Joint European Torus (JET) and other nuclear applications. In this paper, three types are described, together with concepts for use in fusion machines. The Storable Tubular Extendible Member (STEM) was conceived by the National Research Council of Canada and developed by Spar Aerospace Limited. The Astromast is a folding truss developed by Astro Aerospace Corporation, a US subsidiary of Spar. The X-Beam is an ultra-stiff folding truss

  3. Self-organized critical model for protein folding (United States)

    Moret, M. A.


    The major factor that drives a protein toward collapse and folding is the hydrophobic effect. At the folding process a hydrophobic core is shielded by the solvent-accessible surface area of the protein. We study the fractal behavior of 5526 protein structures present in the Brookhaven Protein Data Bank. Power laws of protein mass, volume and solvent-accessible surface area are measured independently. The present findings indicate that self-organized criticality is an alternative explanation for the protein folding. Also we note that the protein packing is an independent and constant value because the self-similar behavior of the volumes and protein masses have the same fractal dimension. This power law guarantees that a protein is a complex system. From the analyzed data, q-Gaussian distributions seem to fit well this class of systems.

  4. A biomorphic origami actuator fabricated by folding a conducting paper

    Energy Technology Data Exchange (ETDEWEB)

    Okuzaki, H; Saido, T; Suzuki, H; Hara, Y; Yan, H [Laboratory of Organic Robotics, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 4-4-37 Takeda, 400-8511 (Japan)], E-mail:


    Cooperation between the electrical conductivity and hygroscopic nature of conducting polymers can provide an insight into the development of a new class of electro-active polymer (EAP) actuators or soft robots working in ambient air. In this paper, we describe an 'origami' actuator fabricated by folding a sheet of conducting 'paper'. The principle lies in the electrically induced changes in the elastic modulus of a humidosensitive conducting polymer film through reversible sorption and desorption of water vapor molecules, which is responsible for amplifying a contraction of the film ({approx} 1%) to more than a 100-fold expansion (> 100%) of the origami actuator. Utilizing the origami technique, we have fabricated a biomorphic origami robot by folding an electrochemically synthesized polypyrrole film into the figure of an accordion shape, which can move with a caterpillar-like motion by repeated expansion and contraction at a velocity of 2 cm min{sup -1}.

  5. A biomorphic origami actuator fabricated by folding a conducting paper

    International Nuclear Information System (INIS)

    Okuzaki, H; Saido, T; Suzuki, H; Hara, Y; Yan, H


    Cooperation between the electrical conductivity and hygroscopic nature of conducting polymers can provide an insight into the development of a new class of electro-active polymer (EAP) actuators or soft robots working in ambient air. In this paper, we describe an 'origami' actuator fabricated by folding a sheet of conducting 'paper'. The principle lies in the electrically induced changes in the elastic modulus of a humidosensitive conducting polymer film through reversible sorption and desorption of water vapor molecules, which is responsible for amplifying a contraction of the film (∼ 1%) to more than a 100-fold expansion (> 100%) of the origami actuator. Utilizing the origami technique, we have fabricated a biomorphic origami robot by folding an electrochemically synthesized polypyrrole film into the figure of an accordion shape, which can move with a caterpillar-like motion by repeated expansion and contraction at a velocity of 2 cm min -1 .

  6. IMPAIRED MOBILITY OF VOCAL FOLDS - etiology and symptoms

    Directory of Open Access Journals (Sweden)

    Karlo Pintarić


    Full Text Available Paresis or paralysis of one or both vocal cords affects some significant aspects of a human life: breathing, swallowing and speech. The major causes for reduced mobility or even immobility are innervation damage, less often fixation of vocal cord or impaired mobility of crycoarytenoid joint. An injury of the superior or/and inferior laryngeal nerve can be a consequence of different medical procedures, tumor growth, trauma, infection, neurological disorders, radiation exposure, toxic damage, impaired circulation of the area or it is idiopathic. The symptoms are different in the case of unilateral and bilateral paresis of the vocal folds. They also depend on the cause for the impaired mobility. In the patients with unilateral vocal fold paresis, hoarseness and aspiration during swallowing are the leading symptoms. In the bilateral vocal fold paralysis, dyspnea prevails. 

  7. Peptide folding in the presence of interacting protein crowders

    Energy Technology Data Exchange (ETDEWEB)

    Bille, Anna, E-mail:; Irbäck, Anders, E-mail: [Computational Biology and Biological Physics, Department of Astronomy and Theoretical Physics, Lund University, Sölvegatan 14A, SE-223 62 Lund (Sweden); Mohanty, Sandipan, E-mail: [Jülich Supercomputing Centre, Institute for Advanced Simulation, Forschungszentrum Jülich, D-52425 Jülich (Germany)


    Using Monte Carlo methods, we explore and compare the effects of two protein crowders, BPTI and GB1, on the folding thermodynamics of two peptides, the compact helical trp-cage and the β-hairpin-forming GB1m3. The thermally highly stable crowder proteins are modeled using a fixed backbone and rotatable side-chains, whereas the peptides are free to fold and unfold. In the simulations, the crowder proteins tend to distort the trp-cage fold, while having a stabilizing effect on GB1m3. The extent of the effects on a given peptide depends on the crowder type. Due to a sticky patch on its surface, BPTI causes larger changes than GB1 in the melting properties of the peptides. The observed effects on the peptides stem largely from attractive and specific interactions with the crowder surfaces, and differ from those seen in reference simulations with purely steric crowder particles.

  8. Dermofat graft in deep nasolabial fold and facial rhytidectomy. (United States)

    Hwang, Kun; Han, Jin Yi; Kim, Dae Joong


    Fat and dermis or the combined tissues are used commonly in augmentation of the nasolabial fold. Guyuron obtained the dermofat graft from either the suprapubic or the groin region. The thickness of the preauricular skin was measured in seven Korean cadavers, five male and two female. We used the dermofat graft out of the preauricular skin remnant after facial rhytidectomy to augment the deep nasolabial fold in a patient. The average thickness of the epidermis was 56 +/- 12 microm, the dermis was 1820 +/- 265 microm thick, and the subcutaneous tissue was 4783 +/- 137 microm. More dense connective tissues, such as SMAS, are seen in the preauricular skin. The dermofat graft was easily obtained and prepared from the leftover preauricular skin after dissection of the lax skin in face lifting. This technique could be employed effectively and successfully to alleviate a deep nasolabial fold and concomitant facial rhytidectomy in an Asian with a thick preauricular skin.

  9. Modulating Phonation Through Alteration of Vocal Fold Medial Surface Contour (United States)

    Mau, Ted; Muhlestein, Joseph; Callahan, Sean; Chan, Roger W.


    Objectives 1. To test whether alteration of the vocal fold medial surface contour can improve phonation. 2. To demonstrate that implant material properties affect vibration even when implant is deep to the vocal fold lamina propria. Study Design Induced phonation of excised human larynges. Methods Thirteen larynges were harvested within 24 hours post-mortem. Phonation threshold pressure (PTP) and flow (PTF) were measured before and after vocal fold injections using either calcium hydroxylapatite (CaHA) or hyaluronic acid (HA). Small-volume injections (median 0.0625 mL) were targeted to the infero-medial aspect of the thyroarytenoid (TA) muscle. Implant locations were assessed histologically. Results The effect of implantation on PTP was material-dependent. CaHA tended to increase PTP, whereas HA tended to decrease PTP (Wilcoxon test P = 0.00013 for onset). In contrast, the effect of implantation on PTF was similar, with both materials tending to decrease PTF (P = 0.16 for onset). Histology confirmed implant presence in the inferior half of the vocal fold vertical thickness. Conclusions Taken together, these data suggested the implants may have altered the vocal fold medial surface contour, potentially resulting in a less convergent or more rectangular glottal geometry as a means to improve phonation. An implant with a closer viscoelastic match to vocal fold cover is desirable for this purpose, as material properties can affect vibration even when the implant is not placed within the lamina propria. This result is consistent with theoretical predictions and implies greater need for surgical precision in implant placement and care in material selection. PMID:22865592

  10. Fabrication of ten-fold photonic quasicrystalline structures

    Directory of Open Access Journals (Sweden)

    XiaoHong Sun


    Full Text Available Compared to periodic crystals, quasicrystals have higher point group symmetry and are more favorable in achieving complete band-gaps. In this report, a top-cut prism interferometer is designed to fabricate ten-fold photonic quasicrystalline structures. By optimizing the exposing conditions and material characteristics, appropriate quasicrystals have been obtained in the SU8 photoresist films. Atomic Force Microscopy and laser diffraction are used to characterize the fabricated structures. The measurement results show the consistence between the theoretical design and experiments. This will provide guidance for the large-area and fast production of ten-fold quasicrystalline structures with high quality.

  11. Vocal fold composition and early glottic carcinoma infiltration

    Directory of Open Access Journals (Sweden)

    Fang Qin


    Full Text Available Abstract Background Current imaging techniques provide only limited information pertaining to the extent of infiltration of laryngeal carcinomas into vocal fold tissue layers. Therefore, it is needed to seek the contribute to the body of knowledge surrounding examination and characterization in laryngeal carcinoma infiltration. Methods Excised larynges were collected from 30 male laryngectomy patients with an average age of 43.5 years (ranging 36 to 55 years and history of smoking (≥10 years exhibiting T1, T2, or subglottal (normal vocal fold carcinomas. Vocal folds were preserved via freezing or immersion in paraffin. The depth of the mucosa, submucosa, and muscular layers in both normal vocal folds and tumor tissues of afflicted vocal folds was measured. Results The average depths of the mucosa, submucosa, and muscular layers in normal vocal folds were 0.15 ± 0.06 mm, 2.30 ± 0.59 mm, and 2.87 ± 0.88 mm, respectively. Infiltration measurements of T1 tumors showed a depth of 1.62 ± 0.51 mm and 1.32 ± 0.49 mm in frozen sections and paraffin-embedded samples, respectively. Similarly, T2 tumors showed a depth of 2.87 ± 0.68 mm and 2.58 ± 0.67 mm in frozen sections and paraffin-embedded samples, respectively. T1 and T2 tumors occupied 24.8 ± 10 and 48.5 ± 15 percent of the normal vocal fold depth, respectively. Conclusion This data provides a baseline for estimating infiltration of laryngeal carcinomas in vocal fold tissue layers, of particular interest to surgeons. This information may be used to assess typical depths of infiltration, thus allowing for more appropriate selection of surgical procedures based on individual patient assessment.

  12. A folding algorithm for extended RNA secondary structures. (United States)

    Höner zu Siederdissen, Christian; Bernhart, Stephan H; Stadler, Peter F; Hofacker, Ivo L


    RNA secondary structure contains many non-canonical base pairs of different pair families. Successful prediction of these structural features leads to improved secondary structures with applications in tertiary structure prediction and simultaneous folding and alignment. We present a theoretical model capturing both RNA pair families and extended secondary structure motifs with shared nucleotides using 2-diagrams. We accompany this model with a number of programs for parameter optimization and structure prediction. All sources (optimization routines, RNA folding, RNA evaluation, extended secondary structure visualization) are published under the GPLv3 and available at

  13. Electrical Conductivity Model of the Mantle Lithosphere of the Slave Craton (NW Canada) and its tectonic interpretation in the context of Geochemical Results (United States)

    Lezaeta, P.; Chave, A.; Evans, R.; Jones, A. G.; Ferguson, I.


    The Slave Craton, northwestern Canada, contains the oldest known rocks on Earth, with exposed outcrop over an area of about 600x400 km2. The discovery of economic diamondiferous kimberlite pipes during the early 1990s motivated extensive research in the region. Over the last six years, four types of deep-probing magnetotelluric (MT) surveys were conducted within the framework of diverse geoscientific programs, aimed at determining the regional-scale electrical structures of the craton. Two of the surveys involved novel acquisition; one through frozen lake ice along ice roads during winter, and the second deploying ocean-bottom instrumentation from float planes during summer. The latter surveys required one year of recording between summers, thus allowing long period transfer functions that lead to mantle penetration depths of over 300 km. Two-dimensional modeling of the MT data from along the winter road showed the existence of a high conductivity zone at depths of 80-120 km beneath the central Slave craton. This anomalous region is spatially coincident with an ultradepleted harzburgitic layer in the upper mantle that was interpreted by others to be related to a subducted slab emplaced during the mid-Archean. A 3-D electrical conductivity model of the Slave lithosphere has been obtained, by trial and error, to fit the magnetic transfer and MT response functions from the lake experiments. This 3-D model traces the central Slave conductor as a NE-SW oriented mantle structure. Its NE-SW orientation coincides with that of a late fold belt system, with the first phase of craton-wide plutonism at ca 2630-2590 Ma, three-part subdivision of the craton based on SKS results, and with a G10 (garnet) geochemical mantle boundaries. All of these highlight a NE-SW structural grain to the lithospheric mantle of the craton, in sharp contrast to the N-S grain of the crust. Constraints on the depth range and lateral extension of the electrical conductive structure are obtained


    Institute of Scientific and Technical Information of China (English)

    GONG Zhen-song; HE Min


    Relationships between large-scale zonal wind anomalies and annual frequency of NW Pacific tropical cyclones and possible mechanisms are investigated with the methods of correlation and composition.It is indicated that when △ U200-△U850 >0 in the eastern tropical Pacific and △ U200- △U850 <0 in western tropical Pacific, the Walker cell is stronger in the Pacific tropical region and the annual frequency of NW Pacific tropical cyclone are above normal. In the years with zonal wind anomalies, the circulation of high and low troposphere and the vertical motions in the troposphere have significant characteristics. In the time scale of short-range climate prediction, zonal wind anomalies in high and low troposphere are useful as a preliminary signal of the annual frequency prediction of NW Pacific tropical cyclones.

  15. ‘A Passport to Cross the Room’: Cosmopolitan Empathy and Transnational Engagement in Zadie Smith’s NW (2012

    Directory of Open Access Journals (Sweden)

    Kristian Shaw


    Full Text Available This article seeks to demonstrate that Zadie Smith’s fourth novel, 'NW' (2012, deviates away from celebratory multiculturalism in Britain, interrogating the struggle between critical cosmopolitanism and melancholia in a twenty-first century urban environment. It will be argued that Smith’s limited geographical focus (on an area in which she was born and continues to reside intimates that the social constructs of the family and local community are more conducive to developing cosmopolitan empathy and meaningful relations. Through an analysis of the ethical values of hospitality and openness, it will be suggested that 'NW' reflects a rise in transnational relations and the construction of a cultural model of cosmopolitan communication haunted by national identity and the difficulties of negotiating cultural diversity. The article will then conclude by examining how 'NW' exposes the racial inequalities and socio-economic disparities continuing to reside at the heart of British urban life.

  16. Evidence of endocrine alteration in the red mullet, Mullus barbatus from the NW Mediterranean

    International Nuclear Information System (INIS)

    Martin-Skilton, Rebeca; Lavado, Ramon; Thibaut, Remi; Minier, Christophe; Porte, Cinta


    Red mullet (Mullus barbatus) were collected from different sampling sites (NW Mediterranean) in spring and autumn, with the aim of assessing potential alterations of the endocrine system. Alkylphenols were measured in fish bile as an indicator of estrogenic exposure. Key enzymatic activities involved in both synthesis (ovarian 17β-hydroxysteroid dehydrogenases and P450 aromatase) and metabolism of steroids were assessed together with histological alterations of the gonads. During the spring sampling, delayed gamete maturation, intersexuality, fibrosis, and depressed ovarian P450 aromatase activity were observed in organisms from the most polluted sites. During the autumn sampling, those effects were less evident, indicating that fish might be more susceptible to endocrine disrupting chemicals during the reproductive period. Nonetheless, enhanced glucuronidation of testosterone and estradiol was observed. Overall, this work provides first evidences of significant alterations in the endocrine system of red mullet from highly impacted areas in the NW Mediterranean. - Red mullet may be more susceptible to endocrine disruptors during the reproductive period

  17. Evidence of endocrine alteration in the red mullet, Mullus barbatus from the NW Mediterranean

    Energy Technology Data Exchange (ETDEWEB)

    Martin-Skilton, Rebeca [Department of Environmental Chemistry, IIQAB-CSIC, Jordi Girona 18, 08034 Barcelona (Spain); Lavado, Ramon [Department of Environmental Chemistry, IIQAB-CSIC, Jordi Girona 18, 08034 Barcelona (Spain); Thibaut, Remi [Department of Environmental Chemistry, IIQAB-CSIC, Jordi Girona 18, 08034 Barcelona (Spain); Minier, Christophe [Laboratoire d' Ecotoxicologie, Universite du Havre, 25 rue Philippe Lebon, B.P. 540, F-76058 Le Havre (France); Porte, Cinta [Department of Environmental Chemistry, IIQAB-CSIC, Jordi Girona 18, 08034 Barcelona (Spain)]. E-mail:


    Red mullet (Mullus barbatus) were collected from different sampling sites (NW Mediterranean) in spring and autumn, with the aim of assessing potential alterations of the endocrine system. Alkylphenols were measured in fish bile as an indicator of estrogenic exposure. Key enzymatic activities involved in both synthesis (ovarian 17{beta}-hydroxysteroid dehydrogenases and P450 aromatase) and metabolism of steroids were assessed together with histological alterations of the gonads. During the spring sampling, delayed gamete maturation, intersexuality, fibrosis, and depressed ovarian P450 aromatase activity were observed in organisms from the most polluted sites. During the autumn sampling, those effects were less evident, indicating that fish might be more susceptible to endocrine disrupting chemicals during the reproductive period. Nonetheless, enhanced glucuronidation of testosterone and estradiol was observed. Overall, this work provides first evidences of significant alterations in the endocrine system of red mullet from highly impacted areas in the NW Mediterranean. - Red mullet may be more susceptible to endocrine disruptors during the reproductive period.

  18. The geostatistical approach for structural and stratigraphic framework analysis of offshore NW Bonaparte Basin, Australia

    International Nuclear Information System (INIS)

    Wahid, Ali; Salim, Ahmed Mohamed Ahmed; Yusoff, Wan Ismail Wan; Gaafar, Gamal Ragab


    Geostatistics or statistical approach is based on the studies of temporal and spatial trend, which depend upon spatial relationships to model known information of variable(s) at unsampled locations. The statistical technique known as kriging was used for petrophycial and facies analysis, which help to assume spatial relationship to model the geological continuity between the known data and the unknown to produce a single best guess of the unknown. Kriging is also known as optimal interpolation technique, which facilitate to generate best linear unbiased estimation of each horizon. The idea is to construct a numerical model of the lithofacies and rock properties that honor available data and further integrate with interpreting seismic sections, techtonostratigraphy chart with sea level curve (short term) and regional tectonics of the study area to find the structural and stratigraphic growth history of the NW Bonaparte Basin. By using kriging technique the models were built which help to estimate different parameters like horizons, facies, and porosities in the study area. The variograms were used to determine for identification of spatial relationship between data which help to find the depositional history of the North West (NW) Bonaparte Basin

  19. New Insight Into The Crustal Structure of The Continental Margin Off NW Sabah/borneo (United States)

    Barckhausen, U.; Franke, D.; Behain, D.; Meyer, H.

    The continental margin offshore NW Sabah/Borneo (Malaysia) has been investigated with reflection and refraction seismics, magnetics, and gravity during the recent cruise BGR01-POPSCOMS. A total of 4000 km of geophysical profiles has been acquired, thereof 2900 km with reflection seismics. Like in major parts of the South China Sea, the area seaward of the Sabah Trough consists of extended continental lithosphere. We found evidence that the continental crust also underlies the continental slope land- ward of the Trough, a fact that raises many questions about the tectonic history and development of this margin. The characteristic pattern of rotated fault blocks and half grabens and the carbon- ates which are observed all over the Dangerous Grounds can be traced a long way landward of the Sabah Trough beneath the sedimentary succession of the upper plate. The magnetic anomalies which are dominated by the magnetic signatures of relatively young volcanic features also continue under the continental slope. The sedimentary rocks of the upper plate, in contrast, seem to generate hardly any magnetic anoma- lies. We suspect that the volcanic activity coincided with the collision of Borneo and the Dangerous Grounds in middle or late Miocene time. The emplacement of an al- lochtonous terrane on top of the extended continental lithosphere could be explained by overthrusting as a result of the collision or it could be related to gravity sliding following a broad uplift of NW Borneo at the same time.

  20. The geostatistical approach for structural and stratigraphic framework analysis of offshore NW Bonaparte Basin, Australia

    Energy Technology Data Exchange (ETDEWEB)

    Wahid, Ali, E-mail:; Salim, Ahmed Mohamed Ahmed, E-mail:; Yusoff, Wan Ismail Wan, E-mail: [Universiti Teknologi PETRONAS, Bandar Seri Iskandar, 32610 Tronoh, Perak (Malaysia); Gaafar, Gamal Ragab, E-mail: [Petroleum Engineering Division, PETRONAS Carigali Sdn Bhd, Kuala Lumpur (Malaysia)


    Geostatistics or statistical approach is based on the studies of temporal and spatial trend, which depend upon spatial relationships to model known information of variable(s) at unsampled locations. The statistical technique known as kriging was used for petrophycial and facies analysis, which help to assume spatial relationship to model the geological continuity between the known data and the unknown to produce a single best guess of the unknown. Kriging is also known as optimal interpolation technique, which facilitate to generate best linear unbiased estimation of each horizon. The idea is to construct a numerical model of the lithofacies and rock properties that honor available data and further integrate with interpreting seismic sections, techtonostratigraphy chart with sea level curve (short term) and regional tectonics of the study area to find the structural and stratigraphic growth history of the NW Bonaparte Basin. By using kriging technique the models were built which help to estimate different parameters like horizons, facies, and porosities in the study area. The variograms were used to determine for identification of spatial relationship between data which help to find the depositional history of the North West (NW) Bonaparte Basin.

  1. Comparison of clay mineral stratigraphy to other proxy palaeoclimate indicators in the Mesozoic of NW Europe. (United States)

    Ruffell, Alastair; McKinley, Jennifer M; Worden, Richard H


    This paper reviews the opportunities and pitfalls associated with using clay mineralogical analysis in palaeoclimatic reconstructions. Following this, conjunctive methods of improving the reliability of clay mineralogical analysis are reviewed. The Mesozoic succession of NW Europe is employed as a case study. This demonstrates the relationship between clay mineralogy and palaeoclimate. Proxy analyses may be integrated with clay mineralogical analysis to provide an assessment of aridity-humidity contrasts in the hinterland climate. As an example, the abundance of kaolinite through the Mesozoic shows that, while interpretations may be difficult, the Mesozoic climate of NW Europe was subject to great changes in rates of continental precipitation. We may compare sedimentological (facies, mineralogy, geochemistry) indicators of palaeoprecipitation with palaeotemperature estimates. The integration of clay mineralogical analyses with other sedimentological proxy indicators of palaeoclimate allows differentiation of palaeoclimatic effects from those of sea-level and tectonic change. We may also observe how widespread palaeoclimate changes were; whether they were diachronous or synchronous; how climate, sea level and tectonics interact to control sedimentary facies and what palaeoclimate indicators are reliable.

  2. Single injection of basic fibroblast growth factor to treat severe vocal fold lesions and vocal fold paralysis. (United States)

    Kanazawa, Takeharu; Komazawa, Daigo; Indo, Kanako; Akagi, Yusuke; Lee, Yogaku; Nakamura, Kazuhiro; Matsushima, Koji; Kunieda, Chikako; Misawa, Kiyoshi; Nishino, Hiroshi; Watanabe, Yusuke


    Severe vocal fold lesions such as vocal fold sulcus, scars, and atrophy induce a communication disorder due to severe hoarseness, but a treatment has not been established. Basic fibroblast growth factor (bFGF) therapies by either four-time repeated local injections or regenerative surgery for vocal fold scar and sulcus have previously been reported, and favorable outcomes have been observed. In this study, we modified bFGF therapy using a single of bFGF injection, which may potentially be used in office procedures. Retrospective chart review. Five cases of vocal fold sulcus, six cases of scars, seven cases of paralysis, and 17 cases of atrophy were treated by a local injection of bFGF. The injection regimen involved injecting 50 µg of bFGF dissolved in 0.5 mL saline only once into the superficial lamina propria using a 23-gauge injection needle. Two months to 3 months after the injection, phonological outcomes were evaluated. The maximum phonation time (MPT), mean airflow rate, pitch range, speech fundamental frequency, jitter, and voice handicap index improved significantly after the bFGF injection. Furthermore, improvement in the MPT was significantly greater in patients with (in increasing order) vocal fold atrophy, scar, and paralysis. The improvement in the MPT among all patients was significantly correlated with age; the MPT improved more greatly in younger patients. Regenerative treatments by bFGF injection—even a single injection—effectively improve vocal function in vocal fold lesions. 4 © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

  3. Landforms along transverse faults parallel to axial zone of folded ...

    Indian Academy of Sciences (India)

    Himalaya, along the Kali River valley, is defined by folded hanging wall ... role of transverse fault tectonics in the formation of the curvature cannot be ruled out. 1. .... Piedmont surface is made up of gravelliferous and ... made to compute the wedge failure analysis (Hoek .... (∼T2) is at the elevation of ∼272 m asl measured.

  4. A history of folding in mathematics mathematizing the margins

    CERN Document Server

    Friedman, Michael


    While it is well known that the Delian problems are impossible to solve with a straightedge and compass – for example, it is impossible to construct a segment whose length is ∛2 with these instruments – the Italian mathematician Margherita Beloch Piazzolla's discovery in 1934 that one can in fact construct a segment of length ∛2 with a single paper fold was completely ignored (till the end of the 1980s). This comes as no surprise, since with few exceptions paper folding was seldom considered as a mathematical practice, let alone as a mathematical procedure of inference or proof that could prompt novel mathematical discoveries. A few question immediately arise: Why did paper folding become a non-instrument? What caused the marginalisation of this technique? And how was the mathematical knowledge, which was nevertheless transmitted and prompted by paper folding, later treated and conceptualised? Aiming to answer these questions, this volume provides, for the first time, an extensive historical study...

  5. Five-fold local symmetry in metallic liquids and glasses

    International Nuclear Information System (INIS)

    Li M Z; Li F X; Zhang H P; Peng H L; Hu Y C; Wang W H


    The structure of metallic glasses has been a long-standing mystery. Owing to the disordered nature of atomic structures in metallic glasses, it is a great challenge to find a simple structural description, such as periodicity for crystals, for establishing the structure–property relationship in amorphous materials. In this paper, we briefly review the recent developments of the five-fold local symmetry in metallic liquids and glasses and the understanding of the structure–property relationship based on this parameter. Experimental evidence demonstrates that five-fold local symmetry is found to be general in metallic liquids and glasses. Comprehensive molecular dynamics simulations show that the temperature evolution of five-fold local symmetry reflects the structural evolution in glass transition in cooling process, and the structure–property relationship such as relaxation dynamics, dynamic crossover phenomena, glass transition, and mechanical deformation in metallic liquids and glasses can be well understood base on the simple and general structure parameter of five-fold local symmetry. (paper)

  6. 77 FR 74513 - Folding Gift Boxes From China (United States)


    ... From China Determination On the basis of the record \\1\\ developed in the subject five-year review, the... boxes from China would be likely to lead to continuation or recurrence of material injury to an industry... Publication 4365 (November 2012), entitled Folding Gift Boxes from China: Investigation No. 731-TA-921 (Second...

  7. The Boundary-Hopf-Fold Bifurcation in Filippov Systems

    NARCIS (Netherlands)

    Efstathiou, Konstantinos; Liu, Xia; Broer, Henk W.


    This paper studies the codimension-3 boundary-Hopf-fold (BHF) bifurcation of planar Filippov systems. Filippov systems consist of at least one discontinuity boundary locally separating the phase space to disjoint components with different dynamics. Such systems find applications in several fields,

  8. Examining a Thermodynamic Order Parameter of Protein Folding. (United States)

    Chong, Song-Ho; Ham, Sihyun


    Dimensionality reduction with a suitable choice of order parameters or reaction coordinates is commonly used for analyzing high-dimensional time-series data generated by atomistic biomolecular simulations. So far, geometric order parameters, such as the root mean square deviation, fraction of native amino acid contacts, and collective coordinates that best characterize rare or large conformational transitions, have been prevailing in protein folding studies. Here, we show that the solvent-averaged effective energy, which is a thermodynamic quantity but unambiguously defined for individual protein conformations, serves as a good order parameter of protein folding. This is illustrated through the application to the folding-unfolding simulation trajectory of villin headpiece subdomain. We rationalize the suitability of the effective energy as an order parameter by the funneledness of the underlying protein free energy landscape. We also demonstrate that an improved conformational space discretization is achieved by incorporating the effective energy. The most distinctive feature of this thermodynamic order parameter is that it works in pointing to near-native folded structures even when the knowledge of the native structure is lacking, and the use of the effective energy will also find applications in combination with methods of protein structure prediction.

  9. Nonintegrability of the unfolding of the fold-Hopf bifurcation (United States)

    Yagasaki, Kazuyuki


    We consider the unfolding of the codimension-two fold-Hopf bifurcation and prove its meromorphic nonintegrability in the meaning of Bogoyavlenskij for almost all parameter values. Our proof is based on a generalized version of the Morales-Ramis-Simó theory for non-Hamiltonian systems and related variational equations up to second order are used.

  10. Periodic and stochastic thermal modulation of protein folding kinetics. (United States)

    Platkov, Max; Gruebele, Martin


    Chemical reactions are usually observed either by relaxation of a bulk sample after applying a sudden external perturbation, or by intrinsic fluctuations of a few molecules. Here we show that the two ideas can be combined to measure protein folding kinetics, either by periodic thermal modulation, or by creating artificial thermal noise that greatly exceeds natural thermal fluctuations. We study the folding reaction of the enzyme phosphoglycerate kinase driven by periodic temperature waveforms. As the temperature waveform unfolds and refolds the protein, its fluorescence color changes due to FRET (Förster resonant Energy Transfer) of two donor/acceptor fluorophores labeling the protein. We adapt a simple model of periodically driven kinetics that nicely fits the data at all temperatures and driving frequencies: The phase shifts of the periodic donor and acceptor fluorescence signals as a function of driving frequency reveal reaction rates. We also drive the reaction with stochastic temperature waveforms that produce thermal fluctuations much greater than natural fluctuations in the bulk. Such artificial thermal noise allows the recovery of weak underlying signals due to protein folding kinetics. This opens up the possibility for future detection of a stochastic resonance for protein folding subject to noise with controllable amplitude.

  11. Measurement of flow separation in a human vocal folds model

    Czech Academy of Sciences Publication Activity Database

    Šidlof, Petr; Doaré, O.; Cadot, O.; Chaigne, A.


    Roč. 51, č. 1 (2011), s. 123-136 ISSN 0723-4864 R&D Projects: GA AV ČR KJB200760801 Institutional research plan: CEZ:AV0Z20760514 Keywords : vocal folds * flow separation * physical model Subject RIV: BI - Acoustics Impact factor: 1.735, year: 2011

  12. Energy Landscapes: From Protein Folding to Molecular Assembly (United States)

    Databases National Security Education Center (NSEC) Center for Nonlinear Studies Engineering Institute assembly is very common in biology and in nanotechnology. Simple examples of self-assembly are the folding efflux pump machinery, ATP synthase, the ribosome, and many others. In nanotechnology, self-assembly has

  13. Conceptual Transformation and Cognitive Processes in Origami Paper Folding (United States)

    Tenbrink, Thora; Taylor, Holly A.


    Research on problem solving typically does not address tasks that involve following detailed and/or illustrated step-by-step instructions. Such tasks are not seen as cognitively challenging problems to be solved. In this paper, we challenge this assumption by analyzing verbal protocols collected during an Origami folding task. Participants…

  14. 76 FR 74704 - Folded Self-Mailers and Unenveloped Mailpieces (United States)


    ... self-mailers (FSM) and unenveloped mailpieces that are mailed at automation or machinable prices. To... and construction of folded self-mailers and unenveloped mailpieces that are mailed at automation or machinable prices. The proposed standards were issued after two years of collaborative work with mailers to...

  15. Biosimulation of inflammation and healing in surgically injured vocal folds. (United States)

    Li, Nicole Y K; Vodovotz, Yoram; Hebda, Patricia A; Abbott, Katherine Verdolini


    The pathogenesis of vocal fold scarring is complex and remains to be deciphered. The current study is part of research endeavors aimed at applying systems biology approaches to address the complex biological processes involved in the pathogenesis of vocal fold scarring and other lesions affecting the larynx. We developed a computational agent-based model (ABM) to quantitatively characterize multiple cellu