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Sample records for fogo selvagem disease

  1. Programmed cell death 1 gene (PDCD1 polymorphism and pemphigus foliaceus (fogo selvagem disease susceptibility

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    Karin Braun-Prado

    2007-03-01

    Full Text Available Pemphigus foliaceus, also known as fogo selvagem, is an autoimmune disease of the epidermis characterized by superficial blisters and antibodies against desmoglein 1. It is a multifactorial disease and genetic susceptibility is oligogenic or polygenic. Considering the crucial function of the programmed cell death 1 molecule (PD-1 in the immune response, the aim of this study was to verify if variants of the PDCD1 gene influence susceptibility and resistance to pemphigus foliaceus, in a case - control disease association study. We analyzed patients (n = 154 and unaffected control individuals (n = 325 of the Brazilian population, in respect to the PD1.3(G,A PD1.5(C,T and PD1.6(A,G single nucleotide polymorphisms (SNPs and also investigated, for the first time, the exon 5 PDCD1 microsatellite (CTGn. The patient and control samples were divided into strata, according to the predominant ancestry of the individuals (African or European. The PD1.5 genotype distribution in the patients sample was almost indistinguishable from that in the control sample, in both population strata. A possible negative association between pemphigus foliaceus and allele PD1.3A was observed in the total African and European ancestry population sample (odds ratio (OR = 0.55, p = 0.066 and should be investigated in forthcoming studies. The PD1.6A allele was over-represented among the patients of predominantly European ancestry due to an increase of both the G/A and the A/A genotypes (OR = 2.12 and 1.74, respectively; p = 0.035. We conclude that polymorphisms of the PDCD1 gene may influence susceptibility to pemphigus foliaceus, at least in Brazilians of predominantly European ancestry.

  2. Environmental risk factors in endemic pemphigus foliaceus (Fogo selvagem). "The Cooperative Group on Fogo Selvagem Research".

    Science.gov (United States)

    Lombardi, C; Borges, P C; Chaul, A; Sampaio, S A; Rivitti, E A; Friedman, H; Martins, C R; Sanches Júnior, J A; Cunha, P R; Hoffmann, R G

    1992-06-01

    Endemic pemphigus foliaceus or Fogo selvagem (FS) is an epidermal organ-specific autoimmune disease mediated by autoantibodies. Individuals at risk are peasants who live and work on farms located in the interior of certain endemic states of Brazil. This case-control study compares a group of 52 FS patients with 52 patients suffering from other dermatoses admitted and followed at the hospital for pemphigus (Hospital do Penfigo) in the city of Goiania, state of Goias. Patients and controls matched 1:1 by age, sex, and occupation were examined by two dermatologists at the time of admission and asked to respond to a prepared questionnaire. This questionnaire concerned current and past (1 and 5 years) exposure to environmental risk factors. The following risk factors were assessed: black fly bites, presence of rodents at home, exposure to cereal dust, exposure to fumes or dust released by tree and shrub removal, and exposure to insecticides. Relative risks were estimated from tabulated data by the odds ratio and tested for significance by the chi-square test. The 95% confidence interval for the odds ratio was also calculated for each of the risk factors. The only risk factor showing an odds ratio significantly different from one was exposure to simuliidae bites (odds ratio 4.7, p less than 0.001). This study reinforces the hypothesis that chronic exposure to black fly antigens may precipitate IgG4 antibody formation in predisposed individuals. These antibodies in turn may cross-react with epidermal antigens and cause acantholysis and the clinical expression of the disease known as FS.

  3. Chronic methyl mercury poisoning may trigger endemic pemphigus foliaceus "fogo selvagem".

    Science.gov (United States)

    Robledo, Mary Ann

    2012-01-01

    In endemic pemphigus foliaceus (EPF) or "fogo selvagem" the epidemiological evidence shows that all the described outbreaks occur on the banks of rivers where there is mercury contamination from alluvium gold mining and deforestation. Pathophysiological evidence shows a similarity to pemphigus induced by sulphydryl (SH-) drugs that act by denaturing cadherins at the desmosomal level, which are the pemphigus antigens. The sulfhydryl radical (SH-) call also thiol or mercaptans from the SH-drugs, act at the level of SH-groups of cystein as would the methyl mercury from the contaminated animals and fish in the diet of humans from endemic areas of pemphigus foliaceus. The methyl mercury would join the SH-groups from the cysteines amino acids from cadherin proteins in the skin. The autoimmune disease would only be triggered in genetically susceptible individuals with human leukocyte antigen HLA-DRB 1 haplotypes, just as Brown-Norway (BN) rats which are susceptible to develop Th2-dependent autoimmunity induced by metals. Immunological evidence from all the seroepidemiological studies could also be explained by binding mechanism of the methyl mercury to the SH-groups from the cysteines in the desmosomal cadherins proteins. The conclusion is that chronic methyl mercury poisoning is the most likely trigger of endemic pemphigus foliaceus "fogo selvagem". To reduce the contamination of methyl mercury in the animals of the polluted rivers is pertinent to the design of campaigns and education programs with the population. Implement reforestation and biological control measures like phytoremediation technologies using decontaminant plants to decrease the methylation, and the process of biomagnifications of the methyl mercury in the Latin-America EPF foci.

  4. Endemic pemphigus foliaceus (fogo selvagem and pemphigus vulgaris: immunoglobulin G heterogeneity detected by indirect immunofluorescence Pênfigo foliáceo endêmico (fogo selvagem e pênfigo vulgar: heterogeneidade da imunoglobulina G detectada através da imunofluorescência indireta

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    Valéria Aoki

    2004-01-01

    Full Text Available Pemphigus are autoimmune intraepidermal blistering diseases in which immunoglobulin G (IgG autoantibodies are directed against desmosomal glycoproteins. The aim of this study was to determine the IgG subclass profile of endemic pemphigus foliaceus (fogo selvagem and pemphigus vulgaris utilizing indirect immunofluorescence. PATIENTS AND METHODS: Twenty-five patients with pemphigus vulgaris, 25 with endemic pemphigus foliaceus (fogo selvagem, and 25 healthy controls were analyzed by indirect immunofluorescence for circulating autoantibodies (total IgG and its subclasses. RESULTS: Our data revealed a significant correlation (P Pênfigos são enfermidades auto-imunes bolhosas intraepidérmicas, onde auto-anticorpos IgG se dirigem contra glicoproteínas desmossomais. O objetivo deste estudo foi determinar o perfil de subclasses de imunoglubulina G no pênfigo foliáceo endêmico (fogo selvagem e no pênfigo vulgar através da imunofluorescência indireta. MÉTODOS: Vinte e cinco doentes de pênfigo foliáceo endêmico (fogo selvagem, 25 de pênfigo vulgar e 25 controles sadios foram analisados através da imunofluorescência indireta, com respeito aos auto-anticorpos circulantes (imunoglobulina G total e subclasses. RESULTADOS: Nossos dados mostram uma correlação estatisticamente significativa (p<0.05 entre atividade da doença e títulos de auto-anticorpos circulantes em ambas as formas de pênfigo, ou seja, títulos negativos relacionaram-se com remissão clínica, enquanto resultados positivos correlacionaram-se com doença em atividade. A análise de subclasses de IgG mostrou que 56% dos doentes de fogo selvagem em remissão apresentaram apenas IgG4 positiva; na doença ativa, IgG4 foi a subclasse predominante, sendo positiva em 100% dos casos. Nos doentes de pênfigo vulgar, apenas 10% dos doentes em remissão apresentaram positividade exclusiva para IgG4; na doença em atividade, IgG4 esteve presente em 78-83,3% dos casos. CONCLUSÕES: A

  5. Polymorphism of the promoter region and exon 1 of the CTLA4 gene in endemic pemphigus foliaceus (fogo selvagem

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    D.P. Pavoni

    2006-09-01

    Full Text Available Endemic pemphigus foliaceus (EPF is an autoimmune bullous skin disease characterized by acantholysis and antibodies against a desmosomal protein, desmoglein 1. Genetic and environmental factors contribute to development of this multifactorial disease. HLA class II and some cytokine gene polymorphisms are the only genetic markers thus far known to be associated with susceptibility to or protection from EPF. The cytotoxic T-lymphocyte antigen-4 gene (CTLA4 encodes a key immunoreceptor molecule that regulates and inhibits T-cell proliferation. It participates in the regulatory process controlling autoreactivity and therefore has been considered a strong candidate gene in autoimmune diseases. In the search for genes that might influence EPF pathogenesis, we analyzed variants of the CTLA4 gene in a sample of 118 patients and 291 controls from a Brazilian population. This is the first study investigating the possible role of polymorphisms of the 2q33 chromosomal region in differential susceptibility to pemphigus foliaceus. Promoter region and exon 1 single nucleotide polymorphisms -318 (C,T and 49 (A,G were genotyped using sequence-specific oligonucleotide probes after amplification by the polymerase chain reaction. The allelic and genotypic frequencies did not differ significantly between the patient and the control groups (-318T: 9.8 and 10.9%, 49G: 33.0 and 35.2% were the allelic frequencies in patients and controls, respectively. In addition, no significant difference was found when the patient and control population samples were stratified by the presence of HLA-DRB1 alleles. We conclude that the CTLA4 -318 (C,T and 49 (A,G polymorphisms do not play a major role in EPF development.

  6. Pênfigo foliáceo endêmico (fogo-selvagem no grupo indígena Xavánte, Mato Grosso, Brasil Endemic pemphigus foliaceus among the Xavánte indians, state of Mato Grosso, Brazil

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    Horacio Friedman

    1992-09-01

    Full Text Available Foi realizado inquérito soro-epidemiológico através de testes de imunofluorescência indireta e imunoprecipitação visando determinar a prevalência do pênfígo foliáceo endêmico (PFE na população indígena Xavánte do Brasil Central. Do total de 163 amostras de soro testadas, 5 (3,1% foram positivas à imunofluorescência. Todos os soros positivos procediam de indivíduos com sintomas clínicos da doença. Não foram observadas diferenças do PFE entre os Xavánte e a população em geral sob o ponto de vista imunológico, já que se verificou uma predominância da IgG4 entre os anticorpos nos pacientes indígenas.A sero-epidemiological survey was carried out by means of indirect immunofluorescence and immunoprecipitation tests in order to determine the prevalence of endemic pemphigus foliaceus (EPF among the Xavánte Indians from Central Brazil. Out of 163 serum samples, 5 (3.1% tested positive for immunofluorescence. All positive sera were from patients showing clinical signs of the disease. The immunological features of EPF among the Xavánte do not differ from those of non-Indian populations, as was observed a predominance of IgG4 among the antibodies of the Indian subjects.

  7. FOGO-2014: Monitoring the Fogo 2014 Eruption, Cape Verde

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    Fernandes, Rui; Faria, Bruno

    2015-04-01

    Fogo volcano, located in the Cape Verde Archipelago offshore Western Africa, is a complete stratovolcano system that was created by the Cape Verde hotspot, forming the island of Fogo. The top (Pico do Fogo) reaches ~2830m above sea level, and raises ~1100m above Chã das Caldeiras, an almost flat circular area with approximately 10 kilometres in the north-south direction and 7 kilometres in the east-west direction. Chã das Caldeiras, surrounded towards the West by the ~1000m high Bordeira rampart, has been inhabited since the early 20th Century, because it is one of the most productive agricultural areas in this semi-arid country. Fogo volcano erupted on November 23, 2014 (~10:00UTC) on a subsidiary vent of the main cone, after 19 years of inactivity. C4G (Collaboratory for Geosciences), a distributed research infrastructure created in 2014 in the framework of the Portuguese Roadmap for Strategic Research Infrastructures, immediately offered support to the Cape Verdean authorities, with the goal of complementing the permanent geophysical monitoring network operated in Fogo island by INMG, the Cape Verdean Meteorological and Geophysical Institute. This permanent network is composed of seven seismographic stations and three tiltmeter stations, and the data is transmitted in real time to the INMG geophysical laboratory in São Vicente Island, where it is analysed on a routine basis. Pre-eruptive activity started to be detected by the permanent monitoring network on October 2014, with earthquakes occurring at depths larger than 15 km. These events led to a first volcanic warning to the Cape Verdean Civil Protection Agency. On November 22 several volcano-tectonic earthquakes were recorded at shallow depths, indicating shallow fracturing. On the basis of this activity, INMG issued a formal alert of an impending eruption to the Civil Protection Agency, ~24 hours before the onset of the eruption. Volcanic tremor and clear tiltmeter signals were recorded about one hour

  8. O papel educativo da fotografia de vida selvagem

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    Cristina Bruzzo

    2013-03-01

    Full Text Available Este texto examina duas reportagens dos fotógrafos James Balog e Michael Nichols, da revista National Geographic, sobre animais selvagens em zoológicos para questionar o que nos ensinam as denominadas fotografias de animais a respeito do lugar reservado à vida selvagem na cultura contemporânea. Partindo das considerações do filósofo francês Didi-Huberman e de estudos sobre a domesticação, busca-se fornecer subsídios para compreender o propósito educativo da fotografia de animais.

  9. Al Berto e a poética do fogo

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    Kenedi Santos Azevedo

    2013-01-01

    O fogo, do latim focus, conota uma multiplicidade de imagens levadas sempre para a intensidade, para o extremo, porque por si só, o fogo é exuberante, fascinante, encantador, deriva-se em chamas, calor, brasa, paixão, erotismo, lume, incêndio e, na arte, uma imaginação ardente. A partir dessas considerações, pretende-se mostrar que a obra do poeta português Al Berto, Horto de Incêndio, relaciona-se com a imagem poética do fogo, desdobrando-se ora em sexualidade, por meio da erotização da pala...

  10. Non-infectious environmental antigens as a trigger for the initiation of an autoimmune skin disease.

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    Qian, Ye; Culton, Donna A; Jeong, Joseph S; Trupiano, Nicole; Valenzuela, Jesus G; Diaz, Luis A

    2016-09-01

    Pemphigus represents a group of organ specific autoimmune blistering disorders of the skin mediated by pathogenic autoantibodies with well-defined antigenic targets. While most of these diseases are sporadic, endemic forms of disease do exist. The endemic form of pemphigus foliaceus (also known as fogo selvagem, FS) exhibits epidemiological features that suggest exposure to hematophagous insect bites are a possible precipitating factor of this autoimmune disease, and provides a unique opportunity to study how environmental factors contribute to autoimmune disease development. FS patients and healthy individuals from endemic regions show an autoreactive IgM response that starts in early childhood and becomes restricted to IgG4 autoantibodies in FS patients. In searching for triggering environmental antigens, we have found that IgG4 and IgE autoantibodies from FS patients cross-react with a salivary antigen from sand flies. The presence of these cross-reactive antibodies and antibody genetic analysis confirming that these antibodies evolve from the same naïve B cells provides compelling evidence that this non-infectious environmental antigen could be the initial target of the autoantibody response in FS. Consequently, FS serves as an ideal model to study the impact of environmental antigens in the development of autoimmune disease.

  11. INTENSIDADE DE QUEIMA DE DIFERENTES RETARDANTES DE FOGO

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    Nilton Cesar Fiedler

    2015-08-01

    Full Text Available RESUMOEsta pesquisa objetivou avaliar o efeito de diversos tipos de retardantes de fogo e dosagens na eficiência de combate aos incêndios florestais. O experimento foi realizado em mesa de combustão, em laboratório com quatro tipos de retardantes de fogo (WD 881, RFC-88, F-500 e HMIS 1-0-0 DPnb em três concentrações (0,5%; 1%; e 1,5%, além de testemunha com água. A dosagem de calda da mistura de retardante com água utilizada foi de 0,5 L por metro quadrado de área. Para a análise, foi medido o tempo que o fogo levou para consumir a área com a aplicação do produto e a distância entre o início da parcela e o local onde o fogo se extinguiu. Durante a queima de cada parcela (tratamento/repetição, foram avaliadas as seguintes variáveis: umidade relativa, velocidade do vento, tempo gasto para o fogo queimar a parcela com e sem o produto e a distância que o fogo avançou na parcela com o produto. Os retardantes com maior eficiência foram o F-500, HMIS 1-0-0 DPnb e WD 881, que apresentaram diferença significativa pelo teste de Tukey a 5% de probabilidade, diferenciando-se da testemunha e do RFC-88. A concentração mais eficiente foi a de 1,5%, com as menores taxas de inflamabilidade em todos os casos.

  12. Luis Buñuel: uma poética do selvagem

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    Eduardo Peñuela Cañizal

    2009-01-01

    This article is an analysis of the effect of rhetorical disruptions at the levels of soundtrack and images inserts in Luis Buñuel’s films. Its main objective consists in detaching fragments of films with the finality of studying the role of a wild poetics Este artículo é uma análise do efeito das rupturas retóricas no nível da trilha sonora e do enxerto de imagens em filmes de Luis Buñuel. Seu principal objetivo é estudar o papel que esses recursos têm numa poética do selvagem.

  13. Vítimas de ferimentos por arma de fogo atendidas pelo SAMU – Sorocaba

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    Guilherme Lippi Ciantelli

    2013-06-01

    Full Text Available A violência externa é a principal causa de morte em população jovem no Brasil, além de contribuir grandemente com as altas taxas de incapacidade. Os ferimentos por arma de fogo são, entre as causas externas, um dos principais responsáveis pelo aumento da morbimortalidade dessas. Neste artigo, os autores relatam uma série de casos de vítimas de ferimento por arma de fogo atendidas pelo SAMU - Sorocaba e discorrem sobre este tema de grande prevalência e importância.

  14. Mortes e crimes cometidos com armas de fogo na cidade autônoma de Buenos Aires, 2002

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    Hugo Spinelli

    Full Text Available A violência se constitui em um dos problemas mais graves da América Latina. O uso de pequenas e leves armas de fogo é considerada a principal responsável por este fato. O objetivo do presente trabalho foi descobrir, a partir de dados do setor saúde, da justiça e da polícia, o número de mortes e crimes envolvendo armas de fogo ocorridos na cidade de Buenos Aires em 2002. Os dados sobre mortalidade e crimes foram obtidos dos Sistemas Nacionais de Estatísticas Vitais e Informação Criminal e os dados sobre apreensão de armas de fogo foram disponibilizados pela Polícia Federal. Utilizaram-se também dados de uma investigação anterior realizada por meio de entrevistas domiciliares a respeito de vitimização por armas de fogo. Durante o período ocorreram 1.304 mortes violentas, dos quais 23.7% corresponderam a mortes provocadas por armas de fogo. Dos 171 indiciamentos policiais por homicídio doloso, 60% haviam sido cometidos com armas de fogo. Das 2.108 pessoas entrevistadas, 6,7% haviam sido vítimas de um crime cometido com arma de fogo. Foram apreendidas 1.887 armas de fogo. A taxa de eventos violentos registrados foi maior nas delegacias da zona sudoeste da cidade, que se caracteriza por condições de vida mais precárias. O impacto da violência e sua relação com armas de fogo constitui-se em um tema relevante da agenda pública.

  15. Lava flow hazard at Fogo Volcano, Cabo Verde, before and after the 2014-2015 eruption

    OpenAIRE

    Richter, Nicole; Favalli, Massimiliano; de Zeeuw-van Dalfsen, Elske; Fornaciai, Alessandro; Silva Fernandes, Rui Manuel; Pérez, Nemesio M.; Levy, Judith; Victória, Sónia Silva; Thomas R. Walter

    2016-01-01

    Lava flow simulations help to better understand volcanic hazards and may assist emergency preparedness at active volcanoes. We demonstrate that at Fogo Volcano, Cabo Verde, such simulations can explain the 2014–2015 lava flow crisis and therefore provide a valuable base to better prepare for the next inevitable eruption. We conducted topographic mapping in the field and a satellite-based remote sensing analysis. We produced the first topographic model of the 2014&ndash...

  16. The Role Played by Rainfall on the Seismicity at Fogo Volcano, Azores

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    Martini, F.; Saccorotti, G.; Riedel, C.; Bean, C. J.; Wallenstein, N. M.; Viveiros, F. M.

    2007-12-01

    Fogo volcano is an active central volcano, with a lake filled caldera, in the central part of Sao Miguel Island, Azores, whose current activity is limited to fumarolic and hydrothermal activity. It is affected by important active tectonic structures, with extremely high seismic activity and micro-seismicity concentrated in very frequent swarms. A recurrent feature of the seismicity observed in volcanic regions is the occurrence of seismic families, whose origins can be attributed to the same source mechanism, acting in the same small rock volume. Doublets/multiplets were identified in this study within a catalogue of small magnitude (usually lack of any main-shock after-shock sequence and organized migration of the hypocenters. This is suggestive of a very heterogeneous stress field. Vp/Vs is found to be lower than usually observed in volcanic areas, an occurrence likely related to the presence of fluid associated with the geothermal system (Saccorotti et al., 2004). Taken together, these two observations suggest that fluid migration/pressurization play a major role in triggering the recorded seismicity. The geothermal fluids around Fogo massif have been identified as derived from meteoric water, which infiltrates through Fogo Lake and the volcano flank and flows from south to north on the northern flank (Carvalho, 1999). These results point to the important role played by rainfall in triggering seismicity at Sao Miguel, possibly through pressure changes at depth in response to surface rain and/or interaction with the geothermal system.

  17. O impacto do tráfico de vida selvagem na segurança de um país

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    Rodrigues, Luis Fernando Casado

    2015-01-01

    Projeto de Graduação apresentado à Universidade Fernando Pessoa como parte dos requisitos para a obtenção do grau de Licenciado em Criminologia A criminologia cada vez mais se interessa pela criminalidade ambiental, sendo o tráfico de vida selvagem uma das maiores problemáticas desta temática. Esta atividade está muitas vezes ligada a grandes associações criminosas internacionais, especialmente no tráfico de Chifres de Rinoceronte e de Marfim. Compreender de que forma este comércio ilegal ...

  18. Atividade analgésica e antiedematogênica de Polygala paniculata L. (Polygalaceae) selvagem e obtida por micropropagação

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    Nogueira,F.L.P.; Fernandes,S.B.O.; G.M. Reis; M.E. Matheus; P.D. Fernandes; C.L.S. Lage; F.S. Menezes

    2005-01-01

    Polygala paniculata L. (Polygalaceae) é uma erva que ocorre em todas as regiões do Brasil. No presente trabalho, foram avaliadas as atividades analgésica, através do teste da placa quente, da retirada de cauda e da formalina, e antiedematogênica, através do teste do edema de orelha induzido por óleo de cróton, dos extratos etanólicos obtidos das partes aéreas de Polygala paniculata selvagem e cultivadas por micropropagação. A aplicação oral do extrato etanólico de Polygala paniculata apresent...

  19. Entre a civilização e a selvajaria : os estereótipos do nativo americano e o selvagem de Brave New World de Aldous Huxley

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    Rebelo, Maria Raquel de Gouveia Durão Pina

    1999-01-01

    A presente dissertação apresenta, num primeiro momento, um estudo dos estereótipos do Ameríndio - nomeadamente o Bom-Selvagem e o canibal feroz e amoral -, formados pela mente branca europeia e americana numa atitude de contraponto entre culturas. Este estudo, baseado em textos representativos de várias épocas, serve de base à deconstrucção satírica que aldous Huxley faz desses estereótipos e à subversão das categorias discursivas oposicionais nas quais eles assentam e que levaram à distinção...

  20. A DECIDUIDADE FOLIAR INDICA A VULNERABILIDADE DE ESPÉCIES LENHOSAS AO FOGO

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    Isabela Codolo de Lucena

    2015-02-01

    Full Text Available Pesquisas indicaram que a ocorrência de queimadas pode ocasionar comportamentos fenológicos divergentes aos padrões comumente descritos. Este estudo teve como objetivo avaliar se a deciduidade foliar pode indicar a vulnerabilidade de espécies lenhosas ao fogo. Os índices de atividade e intensidade de diferentes fenofases foram comparados entre indivíduos queimados e não queimados de espécies lenhosas com diferentes graus de deciduidade foliar (decídua, semidecídua e sempre-verde. Para a espécie decídua, as fenofases vegetativas foram similares entre indivíduos queimados e não queimados. Indivíduos queimados de uma espécie semidecídua apresentaram maior intensidade e atividade das fenofases vegetativas. Para as espécies sempre-verdes, foi registrado o estímulo à produção de novas folhas, retardamento de folhas expandidas e senescentes para indvíduos queimados. Quanto à fenologia reprodutiva, em indivíduos queimados, foram registradas menor intensidade e atividade de frutos verdes e maduros para espécies decídua e semidecídua, bem como o estímulo da floração e da frutificação para as espécies sempre-verdes. A periodicidade das fenofases pode ser modulada pela ocorrência do fogo mesmo após um intervalo de dois anos. O efeito do fogo foi gradualmente mais pronunciado de espécies decíduas às sempre-verdes, o que indica maior vulnerabilidade de espécies lenhosas sempre-verdes a esse distúrbio.

  1. Tracking effusive eruptions in near real-time: 2014 Fogo (Cape Verde) eruption

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    Laiolo, Marco; Coppola, Diego; Cigolini, Corrado; Faria, Bruno; Ripepe, Maurizio

    2015-04-01

    The Fogo volcano (Cape Verde), after almost 20 years of inactivity, entered in a new effusive phase on November 23, 2014. The eruption occurred on the Fogo's Pico cone inside the Cha Caldera where the lava flow caused the evacuation of the Bangaeira and Portela inhabitants. To track the thermal evolution of this eruption, we extended the near-real time processing of the MIROVA (Middle InfraRed Observation of Volcanic Activity) algorithm to Fogo island. MIROVA is a hot-spot detection system based on the analysis of the Moderate Resolution Imaging Spectroradiometer (MODIS) data that provide thermal maps (1 km resolution) and radiant flux estimates, in near real time (1-4 hours from satellite overpass). Thermal output retrieved by MIROVA can be converted into time-average lava discharge rates allowing the identification of ongoing effusive trends. During the first 45 days of activity the eruption shows a waxing-waning trend typical of pressurized closed systems. Preliminary results indicate that MIROVA is particularly efficient to provide near real-time data that are critical for better assessing volcanic risk, and to help the decision-makers during volcanic crisis. Data requested by the UNDAC (United Nations Disaster Assessment and Coordination) team operating in Cape Verde, through the Emergency Response Coordination Center (ERCC) of the European Mechanism of Civil Protection, were provided in near real-time via web to the National Institute of Meteorology and Geophysics and to National Civil Protection. Once compared to seismological data, information provided by MIROVA have been successfully used during the volcanic crisis.

  2. Caracterização da Diatomita de Rio do Fogo - RN - Brasil

    OpenAIRE

    Paula Luciana Bezerra da Silva; Lídia Dely Alves de Sousa; Viviane Pinheiro da Silva; Eiji Harima; José Yvan Pereira Leite

    2010-01-01

    A diatomita é uma substância amorfa, oriunda de carapaças de algas diatomáceas, possui uma grande variedade de aplicações devido as suas propriedades físicas e químicas sendo usado como auxiliar filtrante, isolante acústico, carga industrial, abrasivo e outros. O presente trabalho mostra resultados de caracterização de duas amostras de diatomita do município de Rio do Fogo em Barra de Punaú, no Estado do Rio Grande do Norte, apresentando cor branca e creme após calcinação. As amostras foram c...

  3. Monitoring diffuse He degassing from the summit crater of Pico do Fogo volcano, Cape Verde

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    Alonso, Mar; Dionis, Samara; Fernandes, Paulo; Melián, Gladys; Asensio-Ramos, María; Padilla, Germán D.; Hernández, Pedro A.; Pérez, Nemesio M.; Silva, Sonia

    2017-04-01

    Fogo (476km2) is one of the Sotavento islands of Cape Verde archipelago. The main geomorphological feature is the presence of a 9 km wide caldera hosting one of the world's most active volcanoes, Pico do Fogo (2829 m.a.s.l.), with the last eruption occurring on November 2014. Pico do Fogo volcano is characterized by the existence of a fumarolic field situated NW inside the summit crater and composed by low- and high-temperature gas discharges (90 to above 200oC respectively) with widespread sulfur precipitates at the surface, typical of hydrothermal alteration. As part of the geochemical monitoring program for the volcanic surveillance of Fogo volcano, twelve surveys of diffuse Helium (He) emission through the surface of the crater have been performed since 2008. He emission has been measured because it is considered as an excellent geochemical indicator (Pogorsky and Quirt 1981) due to its geochemical properties. Recent results clearly show the importance of helium emission studies for the prediction of major volcanic events and the importance of continuous monitoring of this gas in active volcanic regions (Padrón et al. 2013). Soil He emission rates were measured always at the same 63 sampling sites distributed inside the crater and covering an area of 0.142km2. At each measurement site, soil gas was collected in 10 cc glass vials with a hypodermic syringe by inserting to 40 cm depth a 50 cm stainless probe and later analyzed for He content by a quadrupole mass spectrometer Pfeiffer Omnistar 422. Diffusive and convective emission values were estimated at each sampling site following the Fick and Darcy's laws. The He emission rate through the crater was estimated after making the spatial interpolation maps using sequential Gaussian simulation. The average emission rate during these eight years of study is 3.3 kg d-1. The emission rate showed an important increase (up to 5.7 kg d-1) eight months before the 2014 eruption onset. During the eruptive period the crater

  4. Sustainable Development Index of Pedras de Fogo /PB: Contributive Subsidies on Planning City Sustainability

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    Gesinaldo Ataíde Cândido

    2010-06-01

    Full Text Available The sustainable development is a complex and fundamental issue to face the environmental crisis and because of that it calls the different segments of the society attention. As a mechanism to understand this important issue, several system- level indicators have arisen in order to measure the level of sustainability of countries, states and more recently, the cities. The aim of this article is to show the sustainability development index of Pedras de Fogo /PB as a mean to purchase the city planning .The methodology applied is based on the research of Martins and Candido (2008,which objective is to measure the sustainability development of the cities. The analysis of the results was obtained through a comparison between the sustainable development level of the other cities in Paraiba with the one of Pedras de Fogo. The results obtained were based not only on Martins and Candido methodology but also semi-structured interviews with some local authorities. The results show that a city sustainable planning is necessary taking into consideration the following dimensions: social, demographic, political -institutional, economic, environmental and cultural.

  5. Insights from fumarole gas geochemistry on the recent volcanic unrest of Pico do Fogo, Cape Verde

    Science.gov (United States)

    Melián, Gladys V.; Dionis, Samara; Asensio-Ramos, María; Padilla, Germán; Fernandes, Paulo; Pérez, Nemesio M.; Sumino, Hirochika; Padrón, Eleazar; Hernández, Pedro A.; Silva, Sónia; Pereira, José Manuel; Semedo, Helio; Cabral, Jeremias

    2015-04-01

    Fogo is a volcanic island of the Cape Verde archipelago and host at its center the active stratovolcano Pico do Fogo (2829 m.a.s.l.). On November 23, 2014 a new volcanic eruption started at the southwestern flank of Pico do Fogo, after 19 years of the last eruptive event. Since 2007, regular sampling and analysis of fumarole gas discharges from a fumarole (F1) has been performed in a yearly basis to monitor the chemical and isotopic gas composition. From 2008, fumarole gas sampling was also performed in a second fumarole (F2). During the period of study, outlet temperature in F1 has ranged between 62 to 159°C, whereas the F2 has ranged between 295 and 344°C. For determination of major gas species, fumarolic gases were collected in evacuated flasks containing a 5N NaOH solution. In addition, condensed steam and non-condensable gases (dry gas) were sampled by flowing the fumarolic gases through a water-cooled condenser. The isotopic composition of He (3He/4He) was determined on dry gas samples at the GRC of Tokyo University. Water vapor is by far the most abundant component, as shown by a gas/steam molar ratio between 0.08 and 0.48, followed by CO2 (384,606 - 988,679 mmol/mol in the dry gas phase). The concentration of the other gases in the gas dry phase and expressed in mol/mol: Stotal varies from 3,411 to 606,054, N2 from 835 to 84,672, H2 from 45.6 to 68,439, CH4 from 0 to 61,785, Cl from 4.9 to 1,729, CO from 0 to 1,396 and He from 4.4 to 617. The presence of O2 in concentrations from 10.4 to 17,350 mol/mol reflects minor air contamination either during sampling or storage, or naturally in the sampled vents. Carbon isotopic composition of Pico do Fogo fumarolic CO2, expressed in d13C-CO2 vs. VPDB notation, varied from -4.62 to -4.06 ‰, whereas 3He/4He data, expressed as R/RA, ranged from 5.70 to 8.81. In the classical He-Ar-N2 triangular diagram, most of samples plot between the He, air and ASW end members, showing compositions variably contaminated by

  6. Multi-disciplinary Monitoring of the 2014 Eruption of Fogo Volcano, Cape Verde

    Science.gov (United States)

    Fernandes, R. M. S.; Faria, B. V. E.

    2015-12-01

    The Fogo volcano, located in the Cape Verde Archipelago (offshore Western Africa), is a complete stratovolcano system. It is the most recent expression of the Cape Verde hotspot, that has formed the archipelago. The summit reaches ~2830m above sea level, and raises 1100m above Chã das Caldeiras, an almost flat circular area. The last eruption of Fogo started on November 23, 2014 (~10:00UTC), after 19 years of inactivity. C4G, a distributed research infrastructure created in 2014 in the framework of the Portuguese Roadmap for Strategic Research Infrastructures, collaborated immediately with INMG, the Cape Verdean Meteorological and Geophysical Institut with the goal of complementing the permanent geophysical monitoring network in operation on Fogo island. The INMG permanent network is composed of seven seismographic stations and three tiltmeter stations, with real-time data transmitted. On the basis of increased pre-event activity (which started in October 2014), INMG issued a formal alert of an impending eruption to the Civil Protection Agency, about 24 hours before the onset of the eruption. Although the eruption caused no casualties or personal injuries due to the warnings issued, the lava expelled by the eruption (which last until the end of January) destroyed the two main villages in the caldera (~1000 inhabitants) and covered vast areas of agricultural land, causing very large economic losses and an uncertain future of the local populations. The C4G team installed a network of seven GNSS receivers and nine seismometers, distributed by the entire island. The data collection started on 28th November 2014, and continued until the end of January 2015. The mission also included a new detailed gravimetric survey of the island, the acquisition of geological samples, and the analysis of the air quality during the eruption. We present here a detailed description of the monitoring efforts carried out during the eruption as well as initial results of the analysis of the

  7. Reducing volcanic risk on Fogo Volcano, Cape-Verde, through a participatory approach: which out coming?

    Science.gov (United States)

    Texier-Teixeira, P.; Chouraqui, F.; Perrillat-Collomb, A.; Lavigne, F.; Cadag, J. R.; Grancher, D.

    2013-11-01

    This research paper presents the outcomes of the Work Package 5 (Socio-economical Vulnerability Assessment and Community-Based Disaster Risk Reduction) of the MIAVITA Research Program (MItigate and Assess risk from Volcanic Impact on Terrain and human Activities) conducted in Fogo Volcano, Cape-Verde. The study lasted for almost 3 yr (May 2010-January 2012) of which most of the time was spent in the village of Chã das Caldeiras, situated within the 9 km-wide caldera of the volcano inside the Fogo Natural Park. The objectives of the program included assessment of the vulnerability of the community at risk in terms of livelihoods, access to resources, and power relations between the local people and the different public and private institutions. These are important factors that need to be investigated in order to understand the root causes of vulnerability of the local people. This case study shows that the voluntary exposure of people at volcanic threats is linked with daily access to sources of livelihood specially agriculture and tourism. This is despite the perception of people of the risk on their lives and properties. In order to counter the factors of vulnerability, the study also aimed to identify and enhance local capacities. To achieve such objective, a Participatory 3-Dimensional Mapping (P3DM) activity was conducted to facilitate the dialogue between the local people and the different stakeholders as well as to prepare plans and measures to reduce volcanic risk. The P3DM was a half success considering that it has not yet led to an operational plan which takes into account the local capacities. The main reasons included (1) the non-participative aspect of the project at the beginning which should have identified priorities for people and let them lead the project to ensure the sustainability (2) deep conflicts within the community which complicated the focus group discussions around the 3-D map, and the difficulties to involve more marginalized people

  8. Reducing volcanic risk on Fogo Volcano, Cape Verde, through a participatory approach: which outcome?

    Science.gov (United States)

    Texier-Teixeira, P.; Chouraqui, F.; Perrillat-Collomb, A.; Lavigne, F.; Cadag, J. R.; Grancher, D.

    2014-09-01

    This research paper presents the outcomes of Work Package 5 (socio-economical vulnerability assessment and community-based disaster risk reduction) of the MIAVITA (MItigate and Assess risk from Volcanic Impact on Terrain and human Activities) research programme conducted on Fogo Volcano, Cape Verde. The study lasted for almost 3 years (May 2010 to January 2012), of which most of the time was spent in the village of Chã das Caldeiras, situated within the 9 km wide caldera of the volcano inside Fogo Natural Park. The objectives of the programme included assessment of the vulnerability of the community at risk in terms of livelihoods, access to resources, and power relations between the local people and the different public and private institutions. These are important factors that need to be investigated in order to understand the root causes of vulnerability of the local people. This case study shows that the voluntary exposure of people to volcanic threats is linked to daily access to sources of livelihood, especially agriculture and tourism. This is despite the perception of people of the risk to their lives and properties. In order to counter the factors of vulnerability, the study also aimed to identify and enhance local capacities. To achieve such an objective, a participatory three-dimensional mapping (P3DM) activity was conducted to facilitate the dialogue between the local people and the different stakeholders as well as to prepare plans and measures to reduce volcanic risk. The P3DM was a half success considering that it has not yet led to an operational plan which takes into account the local capacities. The main reasons included (1) the non-participatory aspect of the project at the beginning which should have identified priorities for people and let them lead the project to ensure the sustainability of (2) deep conflicts within the community which complicated the focus group discussions around the 3-D map, and the difficulties in involving more

  9. Reducing volcanic risk on Fogo Volcano, Cape-Verde, through a participatory approach: which out coming?

    Directory of Open Access Journals (Sweden)

    P. Texier-Teixeira

    2013-11-01

    Full Text Available This research paper presents the outcomes of the Work Package 5 (Socio-economical Vulnerability Assessment and Community-Based Disaster Risk Reduction of the MIAVITA Research Program (MItigate and Assess risk from Volcanic Impact on Terrain and human Activities conducted in Fogo Volcano, Cape-Verde. The study lasted for almost 3 yr (May 2010–January 2012 of which most of the time was spent in the village of Chã das Caldeiras, situated within the 9 km-wide caldera of the volcano inside the Fogo Natural Park. The objectives of the program included assessment of the vulnerability of the community at risk in terms of livelihoods, access to resources, and power relations between the local people and the different public and private institutions. These are important factors that need to be investigated in order to understand the root causes of vulnerability of the local people. This case study shows that the voluntary exposure of people at volcanic threats is linked with daily access to sources of livelihood specially agriculture and tourism. This is despite the perception of people of the risk on their lives and properties. In order to counter the factors of vulnerability, the study also aimed to identify and enhance local capacities. To achieve such objective, a Participatory 3-Dimensional Mapping (P3DM activity was conducted to facilitate the dialogue between the local people and the different stakeholders as well as to prepare plans and measures to reduce volcanic risk. The P3DM was a half success considering that it has not yet led to an operational plan which takes into account the local capacities. The main reasons included (1 the non-participative aspect of the project at the beginning which should have identified priorities for people and let them lead the project to ensure the sustainability (2 deep conflicts within the community which complicated the focus group discussions around the 3-D map, and the difficulties to involve more

  10. Breve notícia da recente erupção na ilha do Fogo e suas consequências

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    Fernando Costa

    1995-06-01

    Full Text Available BRIEF NOTES ABOUT THE RECENT VOLCANIC ERUPTION AT FOGO ISLAND - This article provides a concise description of the volcanic eruption that occurred in 1995 in the island of Fogo (Cape Verde. It focuses on the evolution of the eruption, its characteristics, and the alteration it produced on the topography and morphology of the landscape of Chã das Caldeiras. The consequences of this phenomenon on the human and agricultural occupation are also emphasized.

  11. Editorial - Número temático Manejo do fogo em áreas protegidas

    OpenAIRE

    Ribeiro, Katia Torres; ICMBio; França, Helena; UFABC; Miranda, Heloísa Sinátora; UnB; Berlinck, Christian Niel; ICMBio

    2011-01-01

    Neste segundo número de Biodiversidade Brasileira trazemos ampla e variada discussão sobre o manejo do fogo em áreas protegidas. Abrimos assim a segunda linha editorial da revista, que visa à publicação dos resultados técnico-científicos do processo de avaliação do estado de conservação das espécies bem como, na forma de números temáticos, a discussão, entre pesquisadores de diversas áreas e gestores, de temas críticos relacionados à conservação e ao manejo. A dimensão alcançada pelos incêndi...

  12. Barometry of lavas from the 1951 eruption of Fogo, Cape Verde Islands: Implications for historic and prehistoric magma plumbing systems

    Science.gov (United States)

    Hildner, Elliot; Klügel, Andreas; Hansteen, Thor H.

    2012-03-01

    Fogo is one of the most active oceanic volcanoes in the world. The island was affected by a prehistoric giant lateral collapse that decapitated the summit of the former Monte Amarelo volcano. Subsequent volcanism has partly filled the collapse scar and built up the present-day Cha das Caldeiras plain and the Pico do Fogo stratovolcano. We have conducted a thermobarometric study of historic and prehistoric, basanitic to tephritic rocks in order to gain insight into Fogo's magma plumbing system and the impact of the collapse event on fractionation depths. A main focus was the penultimate 1951 eruption, which produced basanites to tephrites (5.0-8.2 wt.% MgO) at two sites south and northwest of Pico do Fogo. Clinopyroxene-melt barometry of phenocrysts yields a well-confined pressure range of 480-650 MPa for the final crystallization level. Microthermometric data of CO2-dominated fluid inclusions in olivine and clinopyroxene phenocrysts yield systematically lower pressures of 250-430 MPa. Inclusions in cumulate xenoliths yield pressures of 100-290 MPa. The combined data indicate pre-eruptive magma storage in the uppermost mantle between 17 and 22 km depth and syn-eruptive short-term magma stalling within the lower crust at 8-13 km depth. The lower pressures revealed by fluid inclusions in xenoliths may indicate that they originate from pre-1951 magma pulses that stalled and crystallized at variable levels in the crust. There is, however, no petrologic evidence for persistent crustal magma chambers. Clinopyroxene-melt barometric data of other historic and prehistoric eruptions indicate that magma storage and differentiation occurred in the uppermost mantle at pressures between 420 and 870 MPa (15-30 km depth) throughout the subaerial evolution of Fogo. Our data indicate that fractionation depths decreased significantly during a period of about 100 ka representing a strong growth phase of Fogo edifice leading up to the giant Monte Amarelo flank collapse at 123-62 ka

  13. Shallow lacustrine system of the Permian Pedra de Fogo Formation, Western Gondwana, Parnaíba Basin, Brazil

    Science.gov (United States)

    Araújo, Raphael Neto; Nogueira, Afonso César Rodrigues; Bandeira, José; Angélica, Rômulo Simões

    2016-04-01

    The Permian Period of the Parnaíba Basin, northern Brazil, represented here by deposits from the Pedra de Fogo Formation, records important events that occurred in Western Gondwana near its boundary with the Mesozoic Era. The analysis of outcrop based facies from the Permian Pedra de Fogo Formation, which is 100 m thick, carried out along the eastern and western borders of the Parnaiba Basin, allowed the identification of eleven sedimentary facies, which were grouped into three distinct facies associations (FA), representative of a shallow lacustrine system associated with mudflats and ephemeral rivers. Bioturbation, desiccation cracks, silcretes and various siliceous concretions characterize the Pedra de Fogo deposits. The FA1 mudflat deposits occur predominantly at the base of the Pedra de Fogo Formation and consist of laminated claystone/mudstone, mudcrack-bearing sandstones/mudstones and sandstones exhibiting cross-lamination, massive and megaripple bedding. Popcorn-like silicified nodules and casts indicate evaporite deposits. Other common features are silica concretions, silicified tepees and silcretes. FA2 represents nearshore deposits and consists of fine-grained sandstones with evenly parallel lamination, climbing ripple cross-lamination, massive and megaripple bedding and mudstone/siltstone showing evenly parallel lamination. FA3 refers to wadi/inundite deposits, generally organized as fining-upward cycles of metric size, composed of conglomerates and medium-grained pebbly sandstones showing massive bedding and cross-stratification, as well as claystone/siltstone showing evenly parallel to undulate lamination. Scour-and-fill features are isolated in predominantly tabular deposits composed of mudstones interbedded with fine to medium-grained sandstones showing planar to slightly undulate lamination. Silicified plant remains previously classified as belonging to the Psaronius genus found in the uppermost levels of the Pedra de Fogo Formation, near the

  14. Caracterização da Diatomita de Rio do Fogo - RN - Brasil

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    Paula Luciana Bezerra da Silva

    2010-01-01

    Full Text Available A diatomita é uma substância amorfa, oriunda de carapaças de algas diatomáceas, possui uma grande variedade de aplicações devido as suas propriedades físicas e químicas sendo usado como auxiliar filtrante, isolante acústico, carga industrial, abrasivo e outros. O presente trabalho mostra resultados de caracterização de duas amostras de diatomita do município de Rio do Fogo em Barra de Punaú, no Estado do Rio Grande do Norte, apresentando cor branca e creme após calcinação. As amostras foram calcinadas nas temperaturas de 800°C, 900°C e 1000°C, apresentam resultados de Difração de Raios-X, análise química, densidade aparente, BET e MEV. A diatomita creme apresentou maior densidade aparente com 0,4 g/cm³, enquanto que a de cor branca apresenta 0,3 g/cm³. Para o resultado de perda ao fogo a diatomita creme possui maior porcentagem de perda em relação à branca. O ensaio BET demonstrou uma redução significativa da diatomita com aumento de temperatura, tendo, portanto a amostra branca maior redução. Com os resultados apresentados é possível identificar a pontecialidade deste mineral no Estado e buscar novas aplicações.

  15. Evidence for a Mega-Tsunami Generated by Giant Flank Collapse of Fogo Volcano, Cape Verde

    Science.gov (United States)

    Ramalho, R. S.; Madeira, J.; Helffrich, G. R.; Schaefer, J. M.; Winckler, G.; Quartau, R.; Adena, K.

    2013-12-01

    Mega-tsunamis generated by ocean island flank collapses are expected to be some of the most hazardous forces of nature, yet evidence for their near-source effects and inferred high run-ups so far is scarce or hotly debated. A newly discovered deposit on the northern coast of Santiago Island (Cape Verde), however, documents the magnitude and run-up height associated with this kind of event. Additionally to chaotic conglomerates distributed from sea-level up to 100 m elevation standing on slopes as steep as 20°, the deposit comprises a number of scattered megaclasts of submarine lava flows, limestone and tuff. The megaclasts are presently located over a higher substructural slope built on younger subaerial lava flows and at elevations ranging 160-220 m a.s.l. All megaclasts correspond to lithologies that crop out exclusively in nearby cliff faces. The origin of this deposit is consequently attributed to an exceptional wave that plucked blocks from the cliff face, transported them inland and deposited them over the higher slopes of the volcanic edifice. The distribution of the megaclasts, together with the local geomorphology, is in agreement with a tsunami that approached the island edifice from the west and was refracted along its northern flank, flooding a series of northwest-oriented valleys. This suggests that the well-known flank collapse of Fogo volcano, located 55 km west of Santiago, is the most likely source, a hypothesis being tested with surface exposure dating. The inferred run-up exceeded 200 m and is consistent with numerical simulations by Paris et al. 2011, implying that the present Fogo island morphology probably developed by at least one giant flank collapse with devastating near-source effects.

  16. Chemical element accumulation in tree bark grown in volcanic soils of Cape Verde-a first biomonitoring of Fogo Island.

    Science.gov (United States)

    Marques, Rosa; Prudêncio, Maria Isabel; Freitas, Maria do Carmo; Dias, Maria Isabel; Rocha, Fernando

    2015-10-03

    Barks from Prosopis juliflora (acacia) were collected in 12 sites of different geological contexts over the volcanic Fogo Island (Cape Verde). Elemental contents of Ba, Br, Co, Cr, Fe, K, Na, Zn and some rare earth elements (REE)-La, Ce, Sm, Eu, Tb, Yb, and Lu, were obtained for biological samples and topsoils by using k 0-standardized and comparative method of instrumental neutron activation analysis (INAA), aiming the evaluation of chemical elements uptake by acacia bark. This first biomonitoring study of Fogo Island showed that, in general, significant accumulations of trace elements present in high amounts in these soils occur. This can be partially explained by the semi-arid climate with a consequent bioavailability of chemical elements when rain drops fall in this non-polluted environment. REE enrichment factors (EFs) increase with the decrease of ionic radius. Heavy REE (HREE) are significantly enriched in bark, which agrees with their release after the primary minerals breakdown and the formation of more soluble compounds than the other REE, and uptake by plants. Among the potential harmful chemical elements, Cr appears to be partially retained in nanoparticles of iron oxides. The high EFs found in tree barks of Fogo Island are certainly of geogenic origin rather than anthropogenic input since industry and the use of fertilizers is scarce.

  17. The Fogo's Collapse-triggered Megatsunami: Evidence-calibrated Numerical Simulations of Tsunamigenic Potential and Coastal Impact

    Science.gov (United States)

    Omira, Rachid; Ramalho, Ricardo S.; Quartau, Rui; Ramalho, Inês; Madeira, José; Baptista, Maria Ana

    2017-04-01

    Volcanic Ocean Islands are very prominent and dynamic features involving several constructive and destructive phases during their life-cycles. Large-scale gravitational flank collapses are one of the most destructive processes and can present a major source of hazard, since it has been shown that these events are capable of triggering megatsunamis with significant coastal impact. The Fogo volcanic island, Cape Verde, presents evidence for giant edifice mass-wasting, as attested by both onshore and offshore evidence. A recent study by Ramalho et al. (2015) revealed the presence of tsunamigenic deposits that attest the generation of a megatsunami with devastating impact on the nearby Santiago Island, following Fogo's catastrophic collapse. Evidence from northern Santiago implies local minimum run-ups of 270 m, providing a unique physical framework to test collapse-triggered tsunami numerical simulations. In this study, we investigate the tsunamigenic potential associated with Fogo's flank collapse, and its impact on the Islands of the Cape Verde archipelago using field evidence-calibrated numerical simulations. We first reconstruct the pre-event island morphology, and then employ a multilayer numerical model to simulate the flank failure flow towards and under the sea, the ensuing tsunami generation, propagation and coastal impact. We use a digital elevation model that considers the coastline configuration and the sea level at the time of the event. Preliminary numerical modeling results suggest that collapsed volumes of 90-150 km3, in one single event, generate numerical solutions that are compatible with field evidence. Our simulations suggest that Fogo's collapse triggered a megatsunami that reached the coast of Santiago in 8 min, and with wave heights in excess of 250 m. The tsunami waves propagated with lower amplitudes towards the Cape Verde Islands located northward of Fogo. This study will contribute to more realistically assess the scale of risks associated

  18. Lava flow hazard at Fogo Volcano, Cabo Verde, before and after the 2014-2015 eruption

    Science.gov (United States)

    Richter, Nicole; Favalli, Massimiliano; de Zeeuw-van Dalfsen, Elske; Fornaciai, Alessandro; da Silva Fernandes, Rui Manuel; Pérez, Nemesio M.; Levy, Judith; Silva Victória, Sónia; Walter, Thomas R.

    2016-08-01

    Lava flow simulations help to better understand volcanic hazards and may assist emergency preparedness at active volcanoes. We demonstrate that at Fogo Volcano, Cabo Verde, such simulations can explain the 2014-2015 lava flow crisis and therefore provide a valuable base to better prepare for the next inevitable eruption. We conducted topographic mapping in the field and a satellite-based remote sensing analysis. We produced the first topographic model of the 2014-2015 lava flow from combined terrestrial laser scanner (TLS) and photogrammetric data. This high-resolution topographic information facilitates lava flow volume estimates of 43.7 ± 5.2 × 106 m3 from the vertical difference between pre- and posteruptive topographies. Both the pre-eruptive and updated digital elevation models (DEMs) serve as the fundamental input data for lava flow simulations using the well-established DOWNFLOW algorithm. Based on thousands of simulations, we assess the lava flow hazard before and after the 2014-2015 eruption. We find that, although the lava flow hazard has changed significantly, it remains high at the locations of two villages that were destroyed during this eruption. This result is of particular importance as villagers have already started to rebuild the settlements. We also analysed satellite radar imagery acquired by the German TerraSAR-X (TSX) satellite to map lava flow emplacement over time. We obtain the lava flow boundaries every 6 to 11 days during the eruption, which assists the interpretation and evaluation of the lava flow model performance. Our results highlight the fact that lava flow hazards change as a result of modifications of the local topography due to lava flow emplacement. This implies the need for up-to-date topographic information in order to assess lava flow hazards. We also emphasize that areas that were once overrun by lava flows are not necessarily safer, even if local lava flow thicknesses exceed the average lava flow thickness. Our

  19. Sentinel-1 TOPS interferometry for geophysical applications: Dyke intrusion imaged during 2014 Pico do Fogo eruption

    Science.gov (United States)

    Gonzalez, Pablo J.; Marinkovic, Petar; Samsonov, Sergey; Hooper, Andrew; Larsen, Yngvar; Wright, Tim

    2015-04-01

    apply Sentinel-1 TOPS-InSAR to illuminate the deformation accompanying a recent volcanic eruption at Pico do Fogo volcano, Fogo (Cape Verde). The detected deformation is consistent with a shallow near-vertical dyke intrusion, which fed the fissure eruption. The modelling of the deformation interferograms do not seem affected largely by the variable LoS vector, in this case. The presented results prove the potential of Terrain observation by progressive scans (TOPS) interferometry for geophysical applications, in particular using ESA Sentinel-1 mission.

  20. O mostrar-se erótico da linguagem: a construção do etos em Asfalto Selvagem, de Nelson Rodrigues

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    Juliane de Sousa Elesbão

    2016-07-01

    Full Text Available Cette recherche vise observer l’ethos érothique qui prédomine dans le romance Asfalto Selvagem, publié em 1960, par l’écrivain Nelson Rodrigues. L’objectif est d’analyser comment les désirs sexuels sont representés par ce genre de discours, comme les perversions contribuent pour definer une auto-identité et comment les profils érothique, définis par l’auteur, confisent certain réalisme lorsqu’ils sont traités avec une profonde réflexion sur la nature humaine. Par conséquent, en ce qui concerne dans une analyse linguistique, on trouve comme support théorique de la categorie ethos, sauvée de l’antiquité classique par l’analyse du discours de la ligne française, spécifiquement dans les études de Dominique Maingueneau (2001; 2002; 2008a; 2008b; 2010. Suivant le théoricien français cité, sont Amossy (2005, Foucault (2009, pour ne citer que quelques-uns. Cette recherche se déplace également par des discussions au sujet qui est l’auteur et le roman, en relation avec le contexte social et historique dans lequel ils sont inserés. On comprend que le roman Asfalto Selvagem semble un “portrait moral» de la société bourgeoise de Rio de Janeiro pendant des années 1950 et 1960, et pour appuyer  cette lecture de base, ce travail se fonde sur Castro (1988. En réfléchissant sur la sexualité et l’érotisme dans les sociétés modernes, on utilise Reich (1968; 1986, Giddens (1993, parmi d’autres. Après cela, on peut, partiellement, dire que Nelson Rodrigues se demande sur les paradigmes et les stéréotypes du comportement social par l’érotisme manifesté dans son langage ambiguë et libertine, et l’ethos forgé fait tomber les masques sociaux dénoncés par l’auteur.

  1. Tratamento de fratura mandibular por projétil de arma de fogo com uso de fixador externo: relato de caso

    OpenAIRE

    Ribeiro, Igor Lerner Hora; Cerqueira, Lucas Souza; Dultra, Fátima Karoline Almeida; Dultra, Joaquim Almeida; Carneiro Júnior, Bráulio; Azevedo, Roberto Almeida de

    2012-01-01

    p. 341-345 A violência e o uso indiscrimidado das armas de fogo, independente da classe social, tornaram os ferimentos por projétil de arma de fogo (PAF), comum nos grandes centros e geralmente acometem a região maxilofacial, principalmente o terço inferior da face. Nos ferimentos por PAF em face, predominam as fraturas cominutivas em mandíbula e a presença de focos infecciosos. Apesar das diversas possibilidades para tratamento das fraturas mandibulares, o uso de fixadores ext...

  2. Diffuse volcanic gas emission and thermal energy release from the summit crater of Pico do Fogo, Cape Verde

    Science.gov (United States)

    Dionis, Samara M.; Melián, Gladys; Rodríguez, Fátima; Hernández, Pedro A.; Padrón, Eleazar; Pérez, Nemesio M.; Barrancos, Jose; Padilla, Germán; Sumino, Hirochika; Fernandes, Paulo; Bandomo, Zuleyka; Silva, Sónia; Pereira, José M.; Semedo, Hélio

    2015-02-01

    We report the first detailed study of diffuse emission of carbon dioxide (CO2), hydrogen sulfide (H2S), helium (He), and hydrogen (H2) from the summit crater of Pico do Fogo volcano, Cape Verde. Diffuse CO2, H2S, He, and H2 gas fluxes were measured at 57 sampling sites and ranged up to 12,800, 13, 1, and 6 g m-2 day-1, respectively. Soil temperature measurements at each sampling site were used to evaluate the heat flux. Most of the summit crater shows relatively high CO2 efflux, with highest values close to the fumarolic area, suggesting a structural control of the degassing process. In contrast, H2S effluxes were negligible or very low at the summit crater, except close to the fumarolic area where anomalously high CO2 efflux and soil temperatures were also measured. We estimate total CO2, H2S, He, and H2 diffuse gas fluxes of 219 t day-1, 25, 4, and 33 kg day-1, respectively. Based on a H2O/CO2 mass ratio of 1.52 measured at the fumaroles, we estimate a diffuse steam flux from the summit crater of approximately 330 t day-1. The enthalpy of this steam is equivalent to a heat flux of about 10.3 MW. The diffuse gas emission and thermal energy released from the summit crater of Pico do Fogo volcano are comparable to those observed at other volcanoes. Sustained surveillance of Pico do Fogo using these methods will be valuable for monitoring the activity of one of the most active volcanoes in the Atlantic Ocean.

  3. Population size, breeding biology and on-land threats of Cape Verde petrel (Pterodroma feae) in Fogo Island, Cape Verde

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    Zango, Laura; Calabuig, Pascual; Stefan, Laura M.; González-Solís, Jacob

    2017-01-01

    Cape Verde petrel (Pterodroma feae) is currently considered near threatened, but little is known about its population size, breeding biology and on land threats, jeopardizing its management and conservation. To improve this situation, we captured, marked and recaptured (CMR) birds using mist-nets over 10 years; measured and sexed them; monitored up to 14 burrows, deployed GPS devices on breeders and analyzed activity data of geolocators retrieved from breeders in Fogo (Cape Verde). We set cat traps over the colony and investigated their domestic/feral origin by marking domestic cats from a nearby village with transponders, by deploying GPS devices on domestic cats and by performing stable isotope analyses of fur of the trapped and domestic cats. The population of Fogo was estimated to be 293 birds, including immatures (95% CI: 233–254, CMR modelling). Based on geolocator activity data and nest monitoring we determined the breeding phenology of this species and we found biometric differences between sexes. While monitoring breeding performance, we verified a still ongoing cat predation and human harvesting. Overall, data gathered from trapped cats without transponder, cats GPS trips and the distinct isotopic values between domestic and trapped cats suggest cats visiting the colony are of feral origin. GPS tracks from breeders showed birds left and returned to the colony using the sector NE of the islands, where high level of public lights should be avoided specially during the fledging period. Main threats for the Cape Verde petrel in the remaining breeding islands are currently unknown but likely to be similar to Fogo, calling for an urgent assessment of population trends and the control of main threats in all Cape Verde Islands and uplisting its conservation status. PMID:28369105

  4. Multi-payload Multi-platform Tactical Monitoring and Evaluation of the 2014 Eruption of Fogo, Cabo Verde

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    Ferrucci, Fabrizio; Day, Simon; Hirn, Barbara; Faria, Bruno; Zoffoli, Simona

    2015-04-01

    The 2014 eruption on the flank of Pico volcano on the island of Fogo (Cape Verde), started ca. 11h30 UTC on November 23rd. It gave rise to a three-branch lava flow running ca. 4 km to the north, 3 to the west and 2 to the south, totaling about 10 million cubic meters in one month, that destroyed two villages and left about 1,000 homeless among the ca. 37,000 inhabitants of Fogo. This mostly effusive event differs from the much better-known, simultaneous Holuhraun eruption in northern Iceland as its instant (thermal) Radiant Flux barely exceeded 10 GW, whereas the latter peaked over 100 GW. Conversely, whereas the Holuhraun lavas have flowed over uninhabited land, and the associated risk is negligible, the Fogo lavas impacted a populated area and would have produced even greater damage had they escaped the confines of the Mt.Amarelo lateral collapse scar within which Pico do Fogo is located, and flowed down the populated outer slopes of Fogo. Upon request of INMG in the second day of eruption, we brought immediate remote sensing and modelling support, based on all observation means able to provide estimates of physical parameters related to power released, lava effusion rates and flow distance to run, along with also quantitative evaluations of eruptive trends and styles. As needs were scaled on the immediate near-daily release of coherent information concerning ongoing lava effusion, we considered that multispectral electro-optical sensors were more useful than radar sensors. We chose to run in parallel a 'tactical' observation line, based on the automated analytical solving of subresolution equation systems in multispectral data with top revisit rates (15 minutes with SEVIRI onboard the geostationary MSG-3, and 4 to 8 hours with MODIS onboard the polar Terra and Aqua) along with a 'strategic' line centred on the automated equation solving in high-to-very high spatial resolution LEO data provided by CEOS (multispectral pixel footprints ranging from 4 m2 of Pleiades

  5. O papel educativo da fotografia de vida selvagem Le rôle educatif de la photographie de la vie sauvage The educacional purpose of wildlife photography

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    Cristina Bruzzo

    2013-03-01

    Full Text Available Este texto examina duas reportagens dos fotógrafos James Balog e Michael Nichols, da revista National Geographic, sobre animais selvagens em zoológicos para questionar o que nos ensinam as denominadas fotografias de animais a respeito do lugar reservado à vida selvagem na cultura contemporânea. Partindo das considerações do filósofo francês Didi-Huberman e de estudos sobre a domesticação, busca-se fornecer subsídios para compreender o propósito educativo da fotografia de animais.Ce texte examine deux reportages des photographes James Balog et Michael Nichols, de la revue National Geographic, sur les animaux sauvages dans des parcs zoologiques pour questionner ce que nous enseigne les dites photographies d′animaux à propos de la place réservée à la vie sauvage dans la culture contemporaine. Partant des considérations du philosophe français Didi-Huberman et d′études sur la domestication, on cherche à apporter des éléments pour comprendre l′objectif éducatif de la photographie d′animaux.The intention of this paper is to examining two articles of National Geographic photographers James Balog and Michael Nichols on wild animals kept in zoos in order to questioning what the so called photographs of wild animals can teach us on wildlife proper space in contemporary culture. Considering French philosopher′s Didi-Huberman assumptions as well as studies on domestication this paper tries to provide information in order to understand the educational purpose of animal photography.

  6. Mortalidade por homicídios no Brasil na década de 90: o papel das armas de fogo

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    Peres Maria Fernanda Tourinho

    2005-01-01

    Full Text Available OBJETIVO: Descrever a evolução da mortalidade por homicídio no Brasil, na década de 1990, buscando analisar a contribuição das armas de fogo. MÉTODOS: Estudo ecológico descritivo de série temporal para o período 1991 a 2000. Dados sobre óbitos por causas externas, segundo local de residência, foram obtidos para a população total e grupos de sexo. A fonte de dados utilizada foi o Sistema de Informação sobre Mortalidade do Ministério da Saúde (SIM/Datasus. Os homicídios foram classificados em homicídios por armas de fogo, por outros instrumentos e por meios não especificados. Foram calculados a mortalidade proporcional e os coeficientes de mortalidade (/100.000 habitantes. RESULTADOS: Os homicídios foram responsáveis por 33% dos óbitos por causas externas na década de 1990. As armas de fogo contribuíram com mais de 50% dos casos já em 1991, e com cerca de 70% no ano 2000. Esse crescimento ocorreu em ambos os grupos de sexo e em todas as capitais. O coeficiente de mortalidade por homicídio cresceu 27,5%, sendo que o incremento nos homicídios cometidos com armas de fogo foi de 72,5%. No período houve uma queda nos casos decorrentes de instrumentos não especificados, o que pode explicar parte do incremento observado para os homicídios com armas de fogo. CONCLUSÕES: Os dados indicam significativa contribuição das armas de fogo para o crescimento dos homicídios na década de 1990. Problemas na qualidade das informações, tanto no que se refere às mortes com intencionalidade indeterminada como ao tipo de instrumento utilizado, prejudicaram a análise dos dados.

  7. Analyzing land surface temperature variations during Fogo Island (Cape Verde) 2014-2015 eruption with Landsat 8 images

    Science.gov (United States)

    Vieira, D.; Teodoro, A.; Gomes, A.

    2016-10-01

    Land Surface Temperature (LST) is an important parameter related to land surface processes that changes continuously through time. Assessing its dynamics during a volcanic eruption has both environmental and socio-economical interest. Lava flows and other volcanic materials produced and deposited throughout an eruption transform the landscape, contributing to its heterogeneity and altering LST measurements. This paper aims to assess variations of satellite-derived LST and to detect patterns during the latest Fogo Island (Cape Verde) eruption, extending from November 2014 through February 2015. LST data was obtained through four processed Landsat 8 images, focused on the caldera where Pico do Fogo volcano sits. QGIS' plugin Semi-Automatic Classification was used in order to apply atmospheric corrections and radiometric calibrations. The algorithm used to retrieve LST values is a single-channel method, in which emissivity values are known. The absence of in situ measurements is compensated by the use of MODIS sensor-derived LST data, used to compare with Landsat retrieved measurements. LST data analysis shows as expected that the highest LST values are located inside the caldera. High temperature values were also founded on the south-facing flank of the caldera. Although spatial patterns observed on the retrieved data remained roughly the same during the time period considered, temperature values changed throughout the area and over time, as it was also expected. LST values followed the eruption dynamic experiencing a growth followed by a decline. Moreover, it seems possible to recognize areas affected by lava flows of previous eruptions, due to well-defined LST spatial patterns.

  8. Evolution of a Permian Arid Lake System, Upper Pedra de Fogo Formation, Western Border of the Parnaiba Basin

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    Luiz Saturnino de Andrade

    2014-12-01

    Full Text Available Stratigraphic and facies analysis in the Filadélfia region, TO, BR, at the western of the Parnaíba Basin, allowed redefine the paleoenvironment of the upper portion of the Pedra de Fogo Formation of Permian age. The studied deposits are a series of approximately 100 m thick, predominantly siliciclastic, with subordinate carbonates and evaporites, where were defined 21 sedimentary facies that could be grouped into six facies associations (AF: AF1 Lacustrine with ephemeral river deposits; AF2 Storm wave-influenced lake deposits; AF3 Continental sabkha deposits; AF4 Central lake deposits; AF5 Eolian dunes field deposits; and AF6 Lake/oasis deposits with inunditos. These associations indicate that during Permian, an extensive lacustrine arid system developed adjacent to eolian dunes fields and continental sabkha, as well as with contributions from ephemeral rivers. Fluvial incursions into lakes propitiated the formation of suspension lobes and sheet flows (AF1. Sabkha plains (AF3 were formed in the marginal portions of the lake that eventually were influenced by storms waves (AF2, while central zone were site of intense pelitic deposition (AF4. The low supply of eolian sand in this system resulted in the formation of restricted dune fields (AF5, with development of interdune lakes (oasis, where proliferating giant ferns, sporadically flooded by ephemeral rivers (AF6. The facies associations data, corroborated by the paleogeography of the region during the Late Permian, indicate that settling of the top part of the Pedra de Fogo Formation was laid during a hot and arid climate.

  9. Discussões em torno do referendo sobre o comércio de armas de fogo e munição na Folha de S. Paulo

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    Lauriston de Araújo Carvalho

    Full Text Available Resumo Este artigo busca compreender os saberes veiculados pelo jornal Folha de S. Paulo a respeito do referendo das armas de fogo durante o ano de 2005. Foram realizadas buscas no site do jornal versão impressa e online via descritores: referendo; arma de fogo; munição, sendo encontradas 170 reportagens. O material foi analisado pelo software Alceste, que realiza análises de dados textuais, via classificação hierárquica descendente. Os resultados indicam a discussão do referendo organizada em dois eixos de significados da ordem da Segurança Privada x Segurança Pública, no qual temas como o controle das armas ilegais e munição são tratados em segundo plano, mostrando a necessidade do aprofundamento da discussão.

  10. The 2014-15 eruption and the short-term geochemical evolution of the Fogo volcano (Cape Verde): Evidence for small-scale mantle heterogeneity

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    Mata, J.; Martins, S.; Mattielli, N.; Madeira, J.; Faria, B.; Ramalho, R. S.; Silva, P.; Moreira, M.; Caldeira, R.; Moreira, M.; Rodrigues, J.; Martins, L.

    2017-09-01

    Recurrent eruptions at very active ocean island volcanoes provide the ideal means to gain insight on the scale of spatial variations at the mantle source and on temporal changes of magma genesis and evolution processes. In 2014, after 19 years of quiescence, Fogo volcano (Cape Verde Archipelago) experienced a new eruption, with the vents located 200 m from those of the 1995 eruption, and less than 2000 m from those of the 1951 event. This offered a unique opportunity to investigate the existence of small-scale mantle heterogeneities and the short-term compositional evolution of magmas erupted by a very active oceanic volcano like Fogo. Here we present petrological and geochemical data from the early stages of the Fogo's most recent eruption - started on November 23, 2014 - and compare them with the signature of previous eruptions (particularly those of 1995 and 1951). The magmas erupted in 2014 are alkaline (up to 23.4% and 0.94% of normative ne and lc, respectively) with somewhat evolved compositions (Mg # importance to the preservation of a significant part of source heterogeneity by erupted magmas. The decrease in the contribution of an enriched component to the Fogo magmas in the 2014 eruption marks a change on the volcano short-term evolution that was characterized by a progressive increase of the importance of such a component. Nb/U ratios of the 2014 lavas are similar, within 2σ, to the mean value of OIB, but significantly lower than those reported for the 1995 and 1951 eruptions. This is considered to reflect the lack of significant mixing of the 2014 magmas with lithospheric melts, as opposed to what is here hypothesised for the two previous eruptions.

  11. Diffuse Carbon Dioxide (CO2) degassing from the summit crater of Pico do Fogo during the 2014-15 eruption, Cape Verde

    Science.gov (United States)

    Rodríguez, Fatima; Dionis, Samara; Padrón, Eleazar; Fernandes, Paulo; Melián, Gladys V.; Pérez, Nemesio M.; Hernández, Pedro A.; Silva, Sónia; Pereira, José Manuel; Cardoso, Nadir; Asensio-Ramos, María; Barrancos, José; Padilla, Germán; Calvo, David; Semedo, Helio

    2015-04-01

    On January 3, 2015, a new diffuse CO2 degassing survey at the summit crater of Pico do Fogo volcano (2,829 m above sea level) was carried out by ITER/INVOLCAN/UNICV/OVCV research team to investigate the effect of the 2014-15 Fogo eruption on the diffuse degassing through the summit crater. Before the eruption onset on November 23, 2014, these type of surveys were periodically performed by ITER/INVOLCAN/UNICV/OVCV research team since May 2007. The first published data on diffuse CO2 degassing rate from the summit crater of Pico do Fogo volcano (219 ± 36 t d-1) is related to a survey performed on February 2010 (Dionis et al., 2015). Each survey implies about 65 CO2 efflux measurements to obtain a good spatial distribution and cover homogeneously the summit crater area (0.14 km2). Because of the sudden falls of rocks of different sizes inside the summit crater during the January 3 survey, the research team aborted continues working in the summit crater without completing the survey only 32 of the 65 CO2 efflux measurements were performed covering a smaller area (0.065 km2). Observed CO2 efflux values ranged from non detectable ( 300 t d-1). This most recent survey did not cover the hydrothermal alteration zone within the crater, where the highest CO2 efflux measurements are usually recorded. Dionis et al. (2015), Bull. Volcanol., in press;

  12. The 2014-2015 eruption at Fogo volcano: constraining the geometry of the intrusion and erupted volumes with space-geodesy

    Science.gov (United States)

    Bagnardi, M.; González, P. J.; Hooper, A. J.; Wright, T. J.

    2015-12-01

    After twenty years of quiescence, Fogo volcano, the most active in the Cape Verde archipelago, erupted for more than two months between November 2014 and February 2015. Voluminous and fast-moving lava flows were erupted from a linear fissure located at the base of Pico do Fogo cone and inundated the summit area of the volcano, destroying two villages. In our work we first use interferometric synthetic aperture radar (InSAR) data from the European Space Agency's Sentinel-1A satellite, which had been operative for only a few weeks at the time of the onset of the eruption, to constrain the geometry of the intrusion that fed the eruption. The InSAR data was acquired in the TOPS (Terrain Observation by Progressive Scans) mode and the eruption at Fogo represents the first volcanic eruption imaged by Sentinel-1 in its standard acquisition mode. To accurately model TOPS data, variations in both incidence and squint angle of the satellite line-of-sight (LoS) vector need to be taken into account when projecting 3D displacements into the LoS direction. Following this approach, we perform a Bayesian inversion of the InSAR data and infer that the measured deformation is best explained by the intrusion of a sub-vertical dike beneath the southwestern flank of Pico do Fogo cone. This intrusion seems to have first propagated upwards beneath the cone and subsequently laterally towards the southwestern flank of Pico do Fogo, where it reached the surface. Successively, we evaluate differences between pre- and post-eruptive digital elevation models (DEMs) of the volcano to estimate the volume of the most recent lava flows. The DEMs are formed using synthetic aperture radar imagery from the TanDEM-X (TerraSAR add-on for Digital Elevation Measurements) satellite mission and tri-stereo optical imagery from the Pléiades satellite constellation. Preliminary results show that during the 2014-2015 eruption almost 50 million cubic meters of lava were emplaced at the surface of the volcano

  13. Diffuse Hydrogen (H2) emissions from the summit crater of Pico do Fogo before the 2014-15 eruption, Cape Verde

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    Dionis, Samara; Padrón, Eleazar; Melián, Gladys V.; Asensio-Ramos, María; Fernandes, Paulo; Barrancos, José; Rodríguez, Fátima; Padilla, Germán; Calvo, David; Hernández, Pedro A.; Silva, Sónia; Cabral, Jeremias; Bandomo, Zuleyka; Pereira, José Manuel; Semedo, Helio; Pérez, Nemesio M.

    2015-04-01

    Pico do Fogo is an active stratovolcano rising 2,829 m above sea level, situated in Fogo Island (476 km2), Cape Verde. Pico do Fogo has a long eruptive history with about 30 eruptions since its discovery (~1500 AD). On November 23, 2014 a new volcanic eruption started at the southwestern flank of the volcano after 19 years of the last eruptive event on 1995. Diffuse hydrogen (H2) emission from the summit crater of Pico do Fogo has been regularly estimated since 2007 to improve the geochemical monitoring program for the volcano surveillance. H2 is one of the most abundant trace species in volcano-hydrothermal systems and is a key participant in many redox reactions occurring in the volcano-hydrothermal reservoir. Because of its chemical and physical characteristics, H2 moves rapidly though the crust and escapes to the atmosphere. These characteristics make H2 an excellent tracer for processes that occurs in the volcano-hydrothermal systems. The first published data on diffuse H2 degassing rate from Pico do Fogo volcano (37.3 ± 11.3 kg d-1) is related to a field work performed on February 2010 (Dionis et al., 2015). A total of seven diffuse H2 degassing surveys have been carried out during the period 2007-2014. Soil gas H2 concentration measured at 40 cm depth, allowed the computation of its emission rate in about 50 sampling sites selected in the surface environment of Pico do Fogo summit crater (0.14 km2). Both advective (convective) and diffuse components were estimated. The sampling sites were selected to cover homogeneously the study area, allowing the computation of the total H2 emission by sequential Gaussian simulation (sGs). During the study period diffuse H2 emission rate ranged between 2.9 and 163.6 kg d-1. On February 2010, it was observed the first relatively high diffuse H2 emission value which suggests the occurrence of an increase in the heat flow. However, higher observed diffuse H2 emission values than February 2010 were detected on April 2013 (75

  14. Efeito do fogo na produção de frutos de Qualea parviflora Mart. (Vochysiaceae em cerrado sensu stricto

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    Alexandre Cesar Palermo

    2012-08-01

    Full Text Available Entre os muitos efeitos causados por queimadas nas espécies arbóreas nativas do Cerrado, a alteração da produção de frutos tem destaque, pois implica diretamente na manutenção de populações locais. O objetivo deste trabalho foi investigar o efeito de uma queimada prescrita na produção de frutos de Qualea parviflora Mart. em área de Cerrado sensu stricto em Brasília, DF. Foram utilizadas duas áreas de Cerrado sensu stricto, uma submetida a regime de queima bienal em agosto (queimada e outra protegida contra a queima há 14 anos (controle. Em cada área, 10 indivíduos reprodutivos foram selecionados e a sua produção de botões florais, flores e frutos, acompanhada durante 22 meses. Dois meses após uma queimada prescrita em 26 de agosto de 2008, a produção de estruturas reprodutivas foi maior na área queimada do que na área-controle. Contudo, a proporção de botões que geram flores e frutos ("fruit set" foi a mesma nas duas áreas. Na estação reprodutiva seguinte, um ano após a queima não houve produção de inflorescências na área queimada. No entanto, na área-controle a produção de frutos foi maior do que no período anterior. A ausência de produção de flores nos indivíduos da área queimada um ano após o fogo sugere que Q. parviflora pode necessitar de mais de um ano para retornar ao seu ciclo normal de reprodução, indicando que os efeitos de médio e de longo prazo devem ser considerados ao se usar o fogo como instrumento de manejo para redução do combustível em áreas de Cerrado.

  15. Soil gas Rn monitoring at Chã das Caldeiras prior the 2014-15 Fogo eruption, Cape Verde

    Science.gov (United States)

    Padilla, Germán; Barrancos, José; Dionis, Samara; Fernandes, Paulo; Pérez, Nemesio M.; Sagiya, Takeshi; Padrón, Eleazar; Melián, Gladys V.; Hernández, Pedro A.; Silva, Sónia; Pereira, José Manuel; Rodríguez, Fátima; Asensio-Ramos, María; Calvo, David; Semedo, Helio

    2015-04-01

    Since 2007 the ITER-INVOLCAN/UNICV-OVCV/SNPC research team has implemented a geochemical program for the volcanic surveillance of Fogo volcano by means of applying different geochemical methods in a regularly basis (diffuse degassing surveys, fumarole gas sampling, etc.). This program was improved by setting up a geochemical permanent station (CHA01) to perform continuous measurements of soil gas radon (222Rn) and thoron (220Rn) activities at Chã das Caldeiras, more specific in Portela village, since April 20, 2013. Both gases are characterized to ascend towards the surface mainly through cracks or faults via diffusion and/or advection mechanisms dependent of both soil porosity and permeability, which in turn vary as a function of the stress/strain changes at depth. Measurements of 222Rn and 220Rn activities were performed by an alpha-spectrometer after pumping the soil gas from a thermally isolated PVC pipe inserted 1m in the ground. Even though during the study period the recorded data did not show high 222Rn activity values, a change in the temporal evolution of soil gas 222Rn activity was observed. During the first six months, from April to October, 2013, recorded time series of 222Rn and 220Rn activities showed normal background levels with values of 80.5 and 55.2 Bqm-3, respectively. However, from October, 2013, to February, 2014, 222Rn time series showed an increase trend reaching peak values of 396 Bqm-3 and having an average activity of 134 Bqm-3 until the removal of the station on November 25, 2014 due to the potential danger of being destroyed by the lava flows. The observed increase in the soil gas 222Rn activity from October 2013 to February 2014 occurs almost at the same time of slight observed changes in the vertical displacements detected by the geodetic network installed at the Fogo Island by the ITER-INVOLCAN/UNICV-OVCV/SNPC/Nagoya University research team. Since seismic data are not available, we cannot conclude if the observed changes in soil

  16. Tracking the hidden growth of a lava flow field: the 2014-15 eruption of Fogo volcano (Cape Verde)

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    Silva, Sonia; Calvari, Sonia; Hernandez, Pedro; Perez, Nemesio; Ganci, Gaetana; Alfama, Vera; Barrancos, José; Cabral, Jeremias; Cardoso, Nadir; Dionis, Samara; Fernandes, Paulo; Melian, Gladys; Pereira, José; Semedo, Hélio; Padilla, German; Rodriguez, Fatima

    2017-04-01

    Fogo volcano erupted in 2014-15 producing an extensive lava flow field in the summit caldera that destroyed two villages, Portela and Bangaeira. The eruption started with powerful explosive activity, lava fountaining, and a substantial ash column accompanying the opening of an eruptive fissure. Lava flows spreading from the base of the eruptive fissure produced three arterial lava flows, spreading S (Flow 1), N-NW (Flow 2) and W (Flow 3). By a week after the start of the eruption, a master lava tube had already developed within the eruptive fissure and along Flow 2. When Flow 2 front stopped against the N caldera cliff, the whole flow field behind it inflated, and eventually its partial drainage produced a short tube that fed Flow 3, but no lava tube formed within Flow 1. Here we analyze the emplacement processes on the basis of observations carried out directly on the lava flow field and through satellite image, in order to unravel the key factors leading to the development of lava tubes. These tubes were responsible for the rapid expansion of lava for the 7.9 km length of the flow field, as well as the destruction of the Portela and Bangaeira villages. Comparing time-averaged effusion rates (TADR) obtained from satellite and Supply Rate (SR) derived from SO2 flux data, we estimate the amount and timing of the lava flow field endogenous growth, with the aim of developing a tool that could be used for risk mitigation at this and other volcanoes.

  17. Condições de vida e saúde reprodutiva de adolescentes residentes na comunidade de Roda de Fogo, Recife Life conditions and reproductive health of teenagers living in the Roda de Fogo community, Recife

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    Ana Cláudia Figueiró

    2002-12-01

    Full Text Available OBJETIVOS: descrever a situação da gravidez e maternidade em adolescentes de 10 a 19 anos, residentes na comunidade de Roda de Fogo, relacionando sua condição social e famíliar. MÉTODOS: estudo descritivo, censitário, transversal, utilizando dados do Sistema de Informação da Atenção Básica. Variáveis dependentes: adolescente grávida ou mãe. Variáveis independentes relacionadas ao adolescente: sexo, idade, escolaridade e ocupação; relativas à família: domicílio, ocupação e, tipo de emprego dos pais número de residentes casa, cômodos, luz elétrica e participação em grupos comunitários. O chi2 e o odds ratio foram usados para calcular a associação das variáveis. RESULTADOS: 88,0% dos adolescentes estudavam e 7,8% trabalhavam. Maior proporção de mães do que de pais residiam no mesmo domicílio. 91,6% dos pais e 54,3% das mães trabalhavam. 31,1% das famílias participavam de grupos comunitários. Na faixa de 15 a 19 anos 3,8% das adolescentes estavam grávidas e 11,9% eram mães. CONCLUSÕES: a estrutura familiar repercute na vida dos adolescentes e na sua condição de gravidez ou maternidade. Esta condição está associada com o abandono da escola, a ausência do pai e/ou da mãe do domicílio, o desemprego paterno e/ou materno e a menor participação da família em grupos comunitários.OBJECTIVES: to describe pregnancy and maternity of adolescents between 10 and 19 years old living in the Roda de Fogo community relating it to social and family conditions. METHODS: descriptive census, cross-sectional study using data of the Basic Information Attention System. Dependent variables: pregnant or adolescent mothers. Independent variables related to adolescents: Sex, age, education, and job. Related to family: home, job and type of jobs of parents, number of people living in the house, number of rooms, electricity and participation in community groups. The chi2 test and the odds ratio were used to calculate variables

  18. Prática e Formação: Psicólogos na Peritagem em Porte de Arma de Fogo

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    Julia Carolina Rafalski

    Full Text Available Com o desenvolvimento e a crescente atualização da Avaliação Psicológica como área, prática e formação, os diferentes desafios enfrentados pelos psicólogos atuantes nesta temática têm sido discutidos. É pouco comum, contudo, a discussão das práticas e competências dos profissionais que atuam na Concessão de Porte de Arma de Fogo. Com o objetivo de conhecer estas atividades e este contexto de trabalho, foram entrevistados 14 psicólogos atuantes como peritos em concessão de porte de arma de fogo em um estado do Sudeste, sendo todos do sexo feminino, com idades entre 30 e 60 anos (M = 39,1 anos, DP = 7,1 anos. Os resultados apontam que a falta de formação voltada para a peritagem em porte de arma de fogo, bem como a formação deficitária em Avaliação Psicológica, podem conduzir a percepções negativas dentro deste contexto de atuação. A preocupação burocrática e documental que envolve esta avaliação, a falta de parâmetros para avaliação de perfil dos avaliados e o problema do descrédito do psicólogo como avaliador surgiram como temáticas adjacentes, suscitando a discussão do papel da formação na disseminação de melhores práticas profissionais.

  19. Fatores prognósticos do trauma raquimedular por projétil de arma de fogo em pacientes submetidos a laminectomia

    OpenAIRE

    FLORES LEANDRO PRETTO; NASCIMENTO FILHO JOÃO DE SOUZA; PEREIRA NETO ALDO; SUZUKI KUNIO

    1999-01-01

    Os traumas sobre a coluna resultantes de projetil de arma de fogo (PAF) são lesões geralmente graves e muitas vezes com baixo potencial para recuperação neurológica. A indicação cirúrgica destas lesões ainda é motivo de controvérsia. O objetivo deste artigo é identificar fatores no pré e trans-operatório que irão influenciar na recuperação neurológica destes pacientes. Realizamos estudo retrospectivo de 45 pacientes submetidos a laminectomia para trauma raquimedular por PAF, avaliando os segu...

  20. Environmental influences on soil CO 2 degassing at Furnas and Fogo volcanoes (São Miguel Island, Azores archipelago)

    Science.gov (United States)

    Viveiros, F.; Ferreira, T.; Cabral Vieira, J.; Silva, C.; Gaspar, J. L.

    2008-11-01

    Since October 2001, four soil CO 2 flux stations were installed in the island of São Miguel (Azores archipelago), at Fogo and Furnas quiescent central volcanoes. These stations perform measurements by the accumulation chamber method and, as the gas flux may be influenced by external variables, the stations are equipped with several meteorological sensors. Multivariate regression analysis applied to the large datasets obtained allowed observing that the meteorological variables may influence the soil CO 2 flux oscillations from 18% to 50.5% at the different monitoring sites. Additionally, it was observed that meteorological variables (mainly soil water content, barometric pressure, wind speed and rainfall) play a different role in the control of the gas flux, depending on the selected monitoring site and may cause significant short-term (spike-like) fluctuations. These divergences may be potentially explained by the porosity and hydraulic conductivity of the soils, topographic effects, drainage area and different exposure of the monitoring sites to the weather conditions. Seasonal effects are responsible for long-term oscillations on the gas flux. Before a reliable application of soil CO 2 flux to seismic and/or volcanic monitoring, it is important to recognize those environmental influences on the gas flux. In addition, understanding the external meteorological influences on the gas flux may be important for the public health risk assessment, since meteorological parameters may cause also significant indoor CO 2 increases. In a house at Furnas Village (in Furnas volcano caldera), the values detected reached percentages as high as 20.8% due to significant decreases in the barometric pressure.

  1. Palaeointensity Results from 1951 and 1995 Lava Flows, Fogo, Cape Verde: A Comparison between Thellier and LTD-DHT Shaw Methods

    Science.gov (United States)

    Brown, M. C.; Cropsey, J.; Bowles, J. A.; Feinberg, J. M.

    2009-12-01

    As part of an ongoing effort to link the success rate of palaeointensity experiments to specific rock magnetic properties, we present new palaeointensity results from basaltic lavas erupted in 1951 and 1995 on the island of Fogo, Cape Verde. Both Thellier and LTD-DHT Shaw palaeointensity experiments were used to estimate the historical field strength. The intensity of the field during these eruptions is constrained by data from the Mbour geomagnetic observatory (Senegal) and IGRF10. In 1951, the magnetic field intensity at Fogo was approximately 33.8 µT during the eruption of three distinct surface flows, covering approximately 14 km2. The field intensity was approximately 32.5 µT during a 1995 eruption of one large flow that extends 4 km2 across the caldera floor. Different volcanic textures were sampled from multiple sites within both the 1951 and 1995 lava flows, including glass-rich pahoehoe and aa flows, highly vesicular flows, and massive non-vesicular lava. Detailed rock magnetic measurements demonstrate that each site and texture displays distinctively different rock magnetic properties. We assess possible links between the outcome of the Thellier and LTD-DHT palaeointensity experiments and the distribution of magnetic domain states, average oxidation state, and laboratory induced alteration.

  2. Transition from steady to unsteady Plinian eruption column: the VEI 5, 4.6 ka Fogo A Plinian eruption, São Miguel, Azores

    Science.gov (United States)

    Pensa, Alessandra; Cas, Raymond; Giordano, Guido; Porreca, Massimiliano; Wallenstein, Nicolau

    2015-10-01

    The 4.6 ka Fogo A trachytic Plinian eruption on São Miguel Island, Azores, Portugal, is composed by four main phases: 1) Initial phreatomagmatic activity which emplaced thin surge deposits with accretionary lapilli; 2) fully buoyant steady Plinian activity which generated a prominent trachytic basal fall-out deposit; 3) partial collapsing activity, which led to the emplacement of two trachytic-trachydacitic intra-plinian ignimbrites (pink and black ignimbrites) and associated surge deposits, inter-stratified within two fall-out deposits; 4) vent widening and fully collapsing activity which caused the emplacement of the climactic brown trachydacitic ignimbrite. The deposits of these four main phases have been organised into three members FGA1, FGA2 and FGA3, sub-divided into 15 stratigraphic or emplacement units. The fluctuations from a steady to unsteady Plinian eruption column parallel the change in composition of the magma from trachytic to trachydacitic. Although minimal, the change in composition resulted in a marked change in colour of the juvenile clasts from white at the base (first phase) to pink and light-dark grey banded and black (second and third phases) and to dark brown (fourth phase). Density analysis of juvenile clasts revealed that the change in composition did not significantly affect the density of the juvenile pumice pyroclasts, the vesicularity of which increases from 70% to 85% up through the sequence. The pink and the black intra-plinian ignimbrites were emplaced only, within the narrow paleo-valleys of the southern flank with maximum thicknesses of 9 m and 5 m respectively, transitioning onto adjacent topographic highs where thin veneer surge layers were deposited. The fall-out deposits inter-bedded between the ignimbrites lack basal reverse grading, indicating that the eruption column continued to be sustained during the partial collapses generating the intra-plinian ignimbrites. The climactic dark brown ignimbrite was emplaced radially

  3. Mortes e crimes cometidos com armas de fogo na Cidade Autônoma de Buenos Aires, 2002 Firearm-related deaths and crime in the autonomous city of Buenos Aires, 2002

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    Spinelli Hugo

    2006-01-01

    Full Text Available Resumo A violência se constitui em um dos problemas mais graves da América Latina. O uso de pequenas e leves armas de fogo é considerado o principal responsável por esse fato. O objetivo do presente trabalhoé descobrir, a partir de dados do setor de saúde, justiça e polícia, o número de mortes e crimes envolvendo armas de fogo ocorridos na cidade de Buenos Aires, em 2002. Os dados sobre mortalidade e crimes foram obtidos dos Sistemas Nacionais de Estatísticas Vitais e Informação Criminal, e os dados sobre apreensão de armas de fogo foram disponibilizados pela Polícia Federal Argentina.Utilizaram-se também dados de uma investigação anterior, realizada por meio de entrevistas domiciliares a respeito de vitimização por armas de fogo. Durante o período, ocorreram 1.304 mortes violentas, das quais 23,7% foram provocadas por armas de fogo. Dos 171 indiciamentos policiais por homicídio doloso, 60% haviam sido cometidos com armas de fogo. Das 2.108 pessoas entrevistadas, 6,7% haviam sido vítimas de crimes cometidos com arma de fogo. Foram apreendidas 1.887 armas de fogo. A taxa de eventos violentos registrados foi maior nas delegacias da zona sudoeste da cidade, que se caracteriza por condições de vida mais precárias. O impacto da violência e sua relação com armas de fogo constituemse em um tema relevante da agenda pública.Abstract Violence is one of the most serious challenges in Latin American societies. Possession and use of small arms and light weapons are considered to be among the main factors behind it. The aim of this paper is to describe deaths and crimes involving the use of a firearm in the City of Buenos Aires in 2002, focusing the health, justice and police sectors. Data on mortality and crimes were obtained from the National Systems for vital statistics and criminal information; data on firearm seizures were supplied by the Argentine Federal Police. Household interviews conducted for a previous research on

  4. Mortes e crimes cometidos com armas de fogo na cidade autônoma de Buenos Aires, 2002 Firearm-related deaths and crime in the autonomous city of Buenos Aires, 2002

    Directory of Open Access Journals (Sweden)

    Hugo Spinelli

    2006-06-01

    Full Text Available A violência se constitui em um dos problemas mais graves da América Latina. O uso de pequenas e leves armas de fogo é considerada a principal responsável por este fato. O objetivo do presente trabalho foi descobrir, a partir de dados do setor saúde, da justiça e da polícia, o número de mortes e crimes envolvendo armas de fogo ocorridos na cidade de Buenos Aires em 2002. Os dados sobre mortalidade e crimes foram obtidos dos Sistemas Nacionais de Estatísticas Vitais e Informação Criminal e os dados sobre apreensão de armas de fogo foram disponibilizados pela Polícia Federal. Utilizaram-se também dados de uma investigação anterior realizada por meio de entrevistas domiciliares a respeito de vitimização por armas de fogo. Durante o período ocorreram 1.304 mortes violentas, dos quais 23.7% corresponderam a mortes provocadas por armas de fogo. Dos 171 indiciamentos policiais por homicídio doloso, 60% haviam sido cometidos com armas de fogo. Das 2.108 pessoas entrevistadas, 6,7% haviam sido vítimas de um crime cometido com arma de fogo. Foram apreendidas 1.887 armas de fogo. A taxa de eventos violentos registrados foi maior nas delegacias da zona sudoeste da cidade, que se caracteriza por condições de vida mais precárias. O impacto da violência e sua relação com armas de fogo constitui-se em um tema relevante da agenda pública.Violence is one of the most serious challenges in Latin American societies. Possession and use of small arms and light weapons are considered to be among the main factors behind it. The aim of this paper is to describe deaths and crimes involving the use of a firearm in the City of Buenos Aires in 2002, focusing the health, justice and police sectors. Data on mortality and crimes were obtained from the National Systems for vital statistics and criminal information; data on firearm seizures were supplied by the Argentine Federal Police. Household interviews conducted for a previous research on firearm

  5. Regeneração pós-fogo em um fragmento de floresta estacional semidecidual no município de Viçosa, MG

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    Sebastião Martins Venâncio

    2002-01-01

    Full Text Available Estudou-se a vegetação colonizadora seis meses após perturbação por fogo, em uma á rea do Campus da Universidade Federal de Viçosa, em Viçosa (20o 45’ S, 42o 51’ W , MG. A á rea total de floresta secundá ria atingida por incê ndio foi de 12 hectares, apresentando níveis diferenciados de destruição da vegetação. O estudo concentrou-se no trecho onde o efeito do fogo foi mais drá stico, com a destruição total da cobertura vegetal. Dentro da á rea de estudo, foram comparadas duas toposseqüê ncias de relevo: côncavo (ravina e convexo (crista. Em cada toposseqüê ncia, foram instaladas dezoito parcelas contíguas de 5x5 m, totalizando 36 parcelas, nas quais foram identificadas todas as plantas vasculares. No total, foram amostradas 75 espécies, pertencentes a 26 famílias. As famílias mais ricas em espécies foram: Asteraceae (14, Poaceae (10, Malvaceae (7 e Fabaceae (6. Na toposseq üê ncia crista as espécies com maior valor de cobertura foram: Sida carpinifolia seguida de Melinis minutiflora, Diodia alata e Eupatorium laevigatum, e na ravina: Melinis minutiflora, Eupatorium laevigatum, Sida carpinifolia e Sidastrum paniculatum. Todas as parcelas apresentaram mais de 90% da á rea coberta por vegetação herbá cea e subarbustiva, destacando a importâ ncia dessa vegetação inicial na proteção do solo contra processos erosivos em relevos acidentados.

  6. Water prospection in volcanic islands by Time Domain Electromagnetic (TDEM) surveying: The case study of the islands of Fogo and Santo Antão in Cape Verde

    Science.gov (United States)

    Martínez-Moreno, F. J.; Monteiro-Santos, F. A.; Madeira, J.; Bernardo, I.; Soares, A.; Esteves, M.; Adão, F.

    2016-11-01

    Water demand in islands, focused in agriculture, domestic use and tourism, is usually supplied by groundwater. Thus the information about groundwater distribution is an important issue in islands water resources management. Time Domain Electromagnetic (TDEM) provides underground resistivity distribution at greater depths and is of easier application than other methods. In this study TDEM technique was used for groundwater prospection in two volcanic islands with water supply problems, the islands of Fogo and Santo Antão in the Republic of Cape Verde. The 10 islands of Cape Verde Archipelago, located off the coast of Senegal (W Africa), present a semi-arid climate and thus suffer from irregular and scarce precipitation. In the Island of Fogo 26 TDEM soundings, presenting an area distribution, were performed on the SW flank of the volcanic edifice. These allowed obtaining a 3D model composed of 5 layers parallel to the topographic surface separated by 50 m depth down to - 250 m. The results indicate the presence of the water-table at a depth of 150 m in the lower ranges of the W flank of the island, and at > 200 m depth in the area above 250 m above sea level (a.s.l.). In the Island of Santo Antão 32 TDEM soundings, distributed along 5 linear profiles, were obtained on the north-eastern half of the island. The profiles are located in two regions exposed to different humidity conditions to the N and S of the main water divide. The northern flank receives the dominant trade winds first and most of the precipitation and, therefore, the water-table is shallower ( 50 m depth) than in the S ( 100 m depth). Our study demonstrates the applicability and usefulness of the TDEM method for groundwater prospection in high resistivity contexts such as in volcanic islands.

  7. IMPLICAÇÕES DA PLASTICIDADE NEURONAL APÓS REABILITAÇÃO NEUROFUNCIONAL EM PACIENTE COM TRAUMATISMO CRÂNIO-ENCEFÁLICO POR ARMA DE FOGO

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    Geraedson Aristides da SILVA

    2015-12-01

    Full Text Available As lesões crâniocerebrais ocasionadas por armas de fogo mantêm-se em números crescentes nos últimos anos, desencadeando na vida de pacientes e familiares transtornos psíquicos e funcionais capazes de alterar todo ciclo de desenvolvimento sócio-familiar. Objetivo: Relatar o caso de um paciente de quinze anos vítima de traumatismo crânio-encefálico, correlacionando-o com a plasticidade neuronal adquirida através da reabilitação da fisioterapia neurofuncional. Materiais e métodos: Este trabalho constitui-se em um relato de caso com um paciente vítima de traumatismo crânio-encefálico por arma de fogo. Tendo como base da reabilitação, exercícios dos métodos Kabat e Bobath, ou seja, a partir das principais técnicas utilizadas pela fisioterapia neurofuncional. Resultados: Foi possível evidenciar reabilitação neuromotora associada a plasticidade neuronal após um tempo total de dezoito meses consecutivos de fisioterapia com intervenções realizadas quatro vezes por semana com duração média de cinqüenta minutos. Conclusão: Mesmo que na contemporaneidade a fisioterapia neurofuncional seja reconhecida e demonstre resultados eficazes na plasticidade neuronal através deste e de outros estudos, as técnicas utilizadas pela mesma precisam ser amplamente estudadas, de forma individual e agrupadas, para que assim sejam mais evidenciadas a partir de estudos com um maior número de indivíduos.

  8. Suscetibilidade da vegetação ao fogo no sul do Amazonas sob condições meteorológicas atípicas durante a seca de 2005

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    Sumaia Saldanha de Vasconcelos

    2015-06-01

    Full Text Available As condições meteorológicas desempenham importante função no comportamento de queimadas e incêndios florestais na Amazônia. Em anos de secas severas, as queimadas utilizadas no manejo da terra podem sair do controle e queimar extensas áreas de vegetação. Parâmetros meteorológicos e focos de calor foram utilizados para avaliar a suscetibilidade da vegetação ao fogo no sul do Amazonas em um ano sem seca (2004 e com seca severa (2005. O número de células suscetíveis ao fogo foi 84% maior em 2005 (72%, comparando com 2004 (39%. Em 2005, o número de células com focos aumentou 66% e o número de focos 121%. Em 2004, 65% dos focos ocorreram com precipitação entre 40 e 90 mm, 96%, com temperatura média entre 26 e 28 ºC, e 89% com umidade inferior a 65%. Em 2005, 83% dos focos ocorreram com precipitação inferior a 70 mm, 96% com temperatura média entre 24 e 28 ºC e 99% com umidade inferior a 65%. Os parâmetros meteorológicos apresentaram tendência de separação entre anos, mas não entre áreas com e sem focos (PC1 = 84%. Houve maior amplitude de variação desses parâmetros no ano com seca severa, proporcionando um tempo mais quente e seco, potencializando a suscetibilidade da vegetação ao fogo.

  9. Avulsão traumática do nervo óptico por projétil de arma de fogo de grosso calibre: relato de caso Traumatic optic nerve avulsion by high caliber bullet: case report

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    Rogério de Almeida Tárcia

    2006-06-01

    Full Text Available A avulsão traumática do nervo óptico ocorre mais comumente devido a traumas contusos óculo-orbitários. A avulsão do mesmo por projétil de arma de fogo de grosso calibre é causa excepcional desta lesão e deve ser pensada no manejo dos pacientes vítimas de lesões por arma de fogo na região cefálica. O presente trabalho descreve o primeiro caso documentado desta singular lesão ao nervo óptico e tece comentários sobre as diversas outras causas relatadas, mecanismos fisiopatológicos, histologia e condutas.Traumatic optic nerve avulsion occurs most commonly after blunt ocular trauma. Optic nerve avulsion by high caliber bullet is exceptional and must be thought of in the management of those patients victims of gunshot wounds to the globe and orbit. The present paper reports the first documented case of this singular condition of optic nerve injury and comments on several other related causes, pathophysiology mechanisms, histology and management.

  10. Eficiência de um retardante de longa duração na redução da propagação do fogo Efficiency of a long term retardant in the reduction of fire propagation

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    Guido Assunção Ribeiro

    2006-12-01

    Full Text Available Os aceiros não naturais têm sido alternativa viável e de amplo uso no meio florestal, nas unidades de conservação e nas margens de rodovias para a redução na propagação do fogo. O seu principal objetivo é o de quebrar a continuidade do material combustível, compartimentalizando a área preferencialmente por grupo de material combustível homogêneo. Com o surgimento de novos produtos e de novos equipamentos de aplicação, os aceiros tradicionais têm sido substituídos por aceiros molhados, aceiros verdes ou aceiros químicos. Dentre as técnicas existentes, o presente trabalho teve por objetivo testar a melhor dosagem de um supressante de fogo, em uma área de pastagem formada pela gramínea Brachiaria decumbens. O supressante utilizado foi o phos-chek, um produto cujo princípio ativo é uma mistura de fosfato de amônio com sulfato de amônio na concentração de 0,134 kg/L. As dosagens aplicadas foram de 300, 600, 900 e 1.200 mL/m². A aplicação foi feita com bomba costal anti-incêndio, em parcelas de 2,0 x 5,0 m, com quatro repetições, utilizando-se o delineamento experimental de parcelas inteiramente ao acaso. Foram medidos o tempo gasto para o fogo queimar a parcela sem o produto; o tempo gasto para o fogo queimar a parcela com o produto; a distância que o fogo avançou na parcela com o produto; e a intensidade de queima, além do monitoramento do tempo, medindo-se a umidade relativa e a velocidade do vento em períodos de uma hora. A linha de fogo demorou cerca de 25 vezes mais tempo para queimar dentro da parcela com o produto, na dosagem de 1.200 mL/m², que na parte sem o produto. O fogo queimou toda a parcela na dosagem de 300 mL/m², mas o tempo de queima na parte com o produto foi maior que na sem produto. O phos-chek altera a reação da combustão, retardando o processo de queima e, quanto maior a dosagem, maior o efeito na inibição da reação. A melhor dosagem foi a de 1.200 mL/m², mas deve-se estudar o

  11. Diagnóstico do uso do fogo no entorno do Parque Estadual da Serra do Brigadeiro (PESB, MG Diagnosis of the use of fire at Parque Estadual da Serra do Brigadeiro (PESB, MG

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    Verônica Rocha Bonfim

    2003-02-01

    Full Text Available O emprego do fogo é uma prática alternativa comum no meio rural, por ser uma técnica eficiente para diversas finalidades na visão de muitos agricultores. Esta técnica requer uma série de cuidados para não incorrer em desastres ambientais, como incêndios florestais. Os objetivos deste trabalho foram realizar um diagnóstico do uso do fogo pelos produtores rurais do entorno do Parque Estadual da Serra do Brigadeiro (PESB, Estado de Minas Gerais, e verificar sua percepção com relação aos incêndios florestais. Para tanto, foram amostradas três regiões distintas e representativas do entorno do PESB: Araponga, Pedra Bonita e Fervedouro. Os dados foram obtidos mediante entrevistas semi-estruturadas, com uso de questionário. Concluiu-se que o uso do fogo é ainda uma prática comum entre os produtores rurais, por ser mais viável economicamente e pelo seu rápido efeito. Entretanto, há um consenso sobre os prejuízos que ele pode causar ao solo, às suas vidas e ao meio ambiente.The use of fire slash and Burn is a common alternative practice in the rural area, seen by many farmers as an efficient technique for various purposes. However, this technique should be carefully employed so as not to cause environmental disasters, such as forest fires. The objective of this work is to make a diagnosis of the use of fire by farmers nearby the Parque Estadual da Serra do Brigadeiro (PESB, in Minas Gerais and verify their perception of forest fire. The use of fire is still a common practice among farmers since it is economically viable and presents fast results. However, there is a consensus concerning its harmful effects on the soil, human life and the environment.

  12. Micromorfologia de sítios concheiros da Ameroca do Sul: Arqueoestratigrafia e processos de Formação de Sambaquis (Santa Catarina, Brasil) e concheros (Terra do Fogo, Argentina

    OpenAIRE

    Ximena Suarez Villagran

    2012-01-01

    O estudo de oito sambaquis do litoral sul do Estado de Santa Catarina e de um concheiro da Terra do Fogo permitiu entender a dinâmica dos processos de formação de diferentes tipos de concheiros. No caso dos sambaquis catarinenses, o objetivo principal foi compreender os processos de formação culturais(atividades humanas) e naturais (tafonômicos) e suas mudanças ao longo do tempo, a partir da análise estratigráfica de sítios cuja cronologia envolve todo o período de ocupação humana pré-hi...

  13. Temperatura e luz na germinação das sementes de apaga-fogo (Alternanthera tenella Effect of temperature and light on joyweed (Alternanthera tenella seed germination

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    R.S. Canossa

    2008-01-01

    Full Text Available A biologia de plantas daninhas tropicais ainda é, em grande parte, desconhecida, especialmente em relação aos fatos que podem ser aproveitados do ponto de vista do controle cultural. Objetivou-se com este trabalho avaliar a influência da temperatura e da luz na germinação das sementes de Alternanthera tenella. Os tratamentos consistiram em quatro temperaturas (20, 25, 30 e 35 ºC na ausência de luz e na manutenção da temperatura constante de 25ºC na presença e ausência de luz. O teste de germinação foi constituído por quatro repetições de 100 sementes para cada tratamento, colocadas para germinar em caixas plásticas do tipo gerbox e mantidas em câmaras de germinação do tipo BOD. As avaliações de germinação foram diárias e no mesmo horário, computando-se as plântulas normais, quando apresentavam radícula e folhas cotiledonares visíveis. Calcularam-se a germinação total e o índice de velocidade de germinação (IVG após o período de 34 dias, e os resultados correspondem à média de dois experimentos. Foi observado que o aumento da temperatura proporcionou aumento na porcentagem e na velocidade de germinação das sementes até 28,2 ºC, decrescendo a partir dessa temperatura. Na temperatura de 25 ºC, verificou-se que a luz causou incremento na porcentagem e na velocidade de germinação das sementes de apaga-fogo.Biology of tropical weeds is still mostly unknown, especially in relation to facts that could be used as cultural tools for weed management. The present work was aimed at evaluating the infuence of temperature and light on germination of Alternanthera tenella seeds. Treatments consisted of four constant temperature regimes (20, 25, 30 and 35 ºC in absence of light, and constant temperature of 25 ºC in the presence and absence of light. The germination test was conducted with four replicates of 100 seeds per treatment, placed in plastic boxes (gerbox and kept in BOD Germinator. Germination evaluations

  14. Physical anthropology and the description of the 'savage' in the Brazilian Anthropological Exhibition of 1882 Antropologia física e a descrição do 'selvagem' na Exposição Antropológica Brasileira de 1882

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    Juanma Sánchez Arteaga

    2010-06-01

    Full Text Available This paper discusses attempts to popularize scientific knowledge about anthropology through exhibitions of natives in the United States and Brazil from the nineteenth century to the beginnings of the twentieth century. In the First Brazilian Anthropological Exposition (Rio de Janeiro, 1882, a group of Botocudos was characterized in a manner that can be related to the reification of the myth of the savage, an important part of the European culture that played a significant role in the construction of anthropological knowledge in the nineteenth century. From the analyses of such exhibitions, we derive implications for science popularization and education, concerning the ideological undertones of scientific knowledge.Analisa tentativas de popularizar o conhecimento científico em antropologia por meio da exibição de nativos nos Estados Unidos e no Brasil, no século XX e no começo do XX. Focaliza a Primeira Exposição Antropológica Brasileira (Rio de Janeiro, 1882, em que foi apresentado um grupo de Botocudos, de modo relacionável à reificação do mito do selvagem, importante componente da cultura europeia e mais especificamente da construção do conhecimento antropológico no Oitocentos. As conclusões concernem à popularização da ciência e, por extensão, à educação em ciência, em especial quanto aos valores ideológicos subjacentes ao conhecimento científico.

  15. Effects of fire on soil nitrogen dynamics and microbial biomass in savannas of Central Brazil Efeitos do fogo na dinâmica do nitrogênio no solo e biomassa microbiana em área de Cerrado

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    Gabriela Bielefeld Nardoto

    2003-08-01

    Full Text Available The objective of this work was to study the effects of fire on net N mineralization and soil microbial biomass in burned and unburned cerrado stricto sensu sites. The study was carried out from April 1998 to April 2000. The pH values were significantly higher in the burned site while soil moisture content was significantly higher in the unburned site (PO objetivo deste trabalho foi estudar o efeito do fogo sobre as taxas de mineralização líquida de N e biomassa microbiana do solo em áreas de cerrado stricto sensu. O estudo foi realizado entre abril de 1998 e abril de 2000. O pH foi maior na área queimada enquanto o teor de umidade do solo foi maior na área sem queima (P<0,05. A razão C/N do solo foi de 22/1. A concentração de N nítrico disponível ficou entre 1,5 e 2,8 mg kg-1 de matéria seca enquanto a de N amoniacal variou entre 3 e 34 mg kg-1 de matéria seca na área queimada e entre 3 e 22 mg kg-1 de matéria seca na área sem queima. A concentração de N amoniacal aumentou significativamente após o fogo (P<0,05. Pequenos acúmulos de N nítrico no solo ocorreram somente durante curto período na estação chuvosa. A biomassa microbiana teve seu pico máximo em novembro de 1998, chegando a 850 mg kg-1 de C no solo da área queimada. Os dados indicam que o pico da atividade microbiana ocorreu no início das chuvas, com um período inicial de imobilização seguido de mineralização líquida. Ambas as áreas apresentaram um mesmo padrão de mineralização/imobilização, mas com menor produção anual de N mineral na área queimada (14,7 kg ha-1 por ano na área sem queima e 3,8 kg ha-1 por ano na área queimada, um ano após a queima.

  16. CONSIDERAÇÕES SOBRE A FORMA TRÁGICA NA TRAGÉDIA E NO ROMANCE: ANTÍGONA E FOGO MORTO COMO A REPRESENTAÇÃO DO CONFLITO INDIVIDUAL E SOCIAL

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    Bárbara Del Rio Araújo (CEFET-MG/UFMG

    2017-03-01

    Full Text Available Este artigo pretende, a partir da interpretação hegeliana da tragédia Antígona, discutir como o elemento trágico pode ser revelador do traço individual e social, naquilo que diz respeito à formação histórica. Na leitura de Hegel, a peça de Sófocles cria um conflito entre a ordem familiar e a esfera pública. A tensão entre a natureza subjetiva e o lastro cultural constrói o trágico, que, para além da tragédia, é apresentado como um modus reflexivo a compor outros gêneros literários, como, por exemplo, a forma romanesca.  No romance, o conflito trágico pode levar a discussão entre o desejo individual e os limites impostos pela sociedade, encerrando uma esfera-paradoxo, na qual princípios e valores excludentes estão simultaneamente presentes. Especificamente em Fogo morto, o trágico configura a fatura do texto, sendo representativo dos destinos das figuras assim como do próprio sistema nacional, marcado por um processo de progresso conservador. Essa comunicação sobre a forma trágica busca afirmar como o teatro e seus elementos tem relação com a cultura a ponto, até mesmo, de influir em outros gêneros literários, tornando-os, ao mesmo tempo, específicos e pertencentes a uma universalidade. A partir da discussão teórica - implementada por Peter Szondi, Raymond Williams e Terry Eagleton - é possível entender que tanto Antígona quanto Fogo Morto revela concepções de trágico comuns à cultura que pertencem, demonstrando que a arte é uma manifestação do mundo sensível, relegando, assim, a possibilidade de ser um mero produto de regras e imitações.

  17. Uma investigação do ser-aí do menino selvagem à luz do pensamento heideggeriano Una investigación del ser-ahí del niño salvaje a luz del pensamiento heideggeriano An investigation of the Dasein of the wild boy through Heidegger's thought

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    Ana Maria Lopez Calvo de Feijoo

    2012-08-01

    Full Text Available Este trabalho busca, na história de Victor de Aveyron, elementos para discutir o modo pelo qual a existência humana se constitui. Por não ter convivido em ambiente humano, Victor foi motivo de intensas discussões no meio científico, especialmente entre os empiristas e os racionalistas. Nesta pesquisa assumimos uma postura fenomenológica, trazendo a história do menino selvagem à discussão por meio da fenomenologia hermenêutica de Heidegger, apontando, assim, para o caráter de indeterminação, o "ter de ser", e de singularidade da existência, sempre em jogo na constituição do modo de ser do homem.Este trabajo busca en la historia de Víctor de Aveyron elementos para discutir el modo por el cual la existencia humana se constituye. Por no haber convivido en ambiente humano, Víctor ha sido motivo de intensas discusiones en el medio científico, especialmente entre los empiristas y los racionalistas. En esta investigación asumimos una postura fenomenológica, trayendo la historia do menino salvaje a discusión por medio de la fenomenología hermenéutica de Heidegger, apuntando, así, para el carácter de indeterminación, o "tener de ser", e de singularidad de la existencia, siempre en juego en la constitución del modo de ser del hombre.This work aims to find, in the story of Victor of Aveyron, elements to discuss the way in which human existence is constituted. For not having lived in the human environment, Victor was the subject of intense discussions within the scientific community, especially among empiricists and rationalists. In this research we take a phenomenological approach, bringing the story of the wild boy into the discussion through the Heidegger's phenomenology hermeneutic, pointing to the character of indeterminacy, mineness; and the singularity of the existence, always presented in the constitution of man's way of being.

  18. Produção de xilanases por uma cepa selvagem de Aspergillus nidulans - DOI: 10.4025/actascibiolsci.v25i1.2095 Xylanase production by a wild strain of Aspergillus nidulans - DOI: 10.4025/actascibiolsci.v25i1.2095

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    Maria Aparecida Ferreira Costa

    2003-04-01

    Full Text Available Uma cepa selvagem de Aspergillus nidulans isolada de solo produziu xilanase isenta de atividade celulolítica quando desenvolvida em meio submerso contendo sabugo de milho como principal substrato. Produção máxima de xilanase (220 U/mL foi obtida quando a cepa foi desenvolvida em meio mineral suplementado com sabugo de milho a 3% (p/v por 6 dias. Eletroforese com SDS revelou a ocorrência de quatro iso-xilanases, com pesos moleculares de 50, 43, 20 e 18 kDa. A xilanase bruta foi resistente à precipitação com acetona, apresentando atividade ótima em pH 5.0-6.0 e temperatura entre 50º e 55ºC. A enzima exibiu grande estabilidade quando exposta a condições alcalinas, e foi estável por várias horas quando exposta a temperaturas de até 55ºC, retendo 50% e 23% de sua atividade quando aquecida por 1 h a 60 e 65ºC, respectivamenteA wild strain of Aspergillus nidulans isolated from soil produce cellulase-free xylanase activity when developed on submerged cultures using corn cob powder as the main substrate. Maximum xylanase production (220 U/mL was obtained when the strain was developed in mineral medium supplemented with 3% (w/v corn cob for 6 days. SDS-PAGE revealed the occurrence of four isoxylanases with molecular weights of 50, 43, 20 and 18 kDa. Crude xylanase was resistant to acetone precipitation with 80% of recovery. The enzyme had optimal activity at pH values between 5.0 and 6.0 and temperature between 50-55oC. The enzyme exhibited high stability under alkaline conditions and temperature up to 55oC. It retained 50% and 23% of its activity when heated for 1 h at 60 and 65oC, respectively

  19. Terapêutica interdisciplinar para fratura cominutiva de côndilo por projétil de arma de fogo: enfoque miofuncional Interdisciplinary approach for comminuted condyle fracture of by firearms: myofunctional focus

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    Esther Mandelbaum Gonçalves Bianchini

    2010-10-01

    Full Text Available TEMA: ferimentos causados por projéteis de arma de fogo apresentam alta incidência na região da cabeça e face. A articulação temporomandibular pode estar envolvida, além de estruturas anatômicas importantes como o nervo facial, necessitando de equipe multidisciplinar para efetuar tratamento adequado. PROCEDIMENTOS: apresentação de caso clínico de fratura condilar cominutiva causada por projétil de arma de fogo tratado de forma não-cirúrgica associado à terapia miofuncional orofacial. Paciente encaminhado para avaliação e procedimentos fonoaudiológicos após conduta da equipe de cirurgia bucomaxilofacial, sem remoção do projétil, alojado superficialmente, próximo da origem do músculo esternocleidomastóideo à direita, com fratura condilar cominutiva e lesão do nervo facial. Foram aspectos observados em avaliação: mordida aberta anterior, importante redução da amplitude dos movimentos mandibulares com desvios para o lado acometido, ausência de lateralidade contralateral, dor muscular, paralisia e parestesia em terço médio e superior da hemiface direita. Realizadas sessões de terapia miofuncional seguindo protocolo específico para traumas de face constando de: drenagem de edema; manipulações na musculatura levantadora da mandíbula ipsilateral; ampliação e correção dos movimentos mandibulares; procedimentos específicos referentes à paralisia facial e reorganização funcional direcionada. RESULTADOS: após oito semanas de terapia os resultados obtidos mostram restabelecimento de amplitude e da simetria dos movimentos mandibulares, reorganização da mastigação, adequação da deglutição e fala, remissão da sintomatologia dolorosa e remissão da paralisia do terço médio. CONCLUSÃO: o tratamento conservador da fratura por meio da terapia miofuncional orofacial resultou na reabilitação funcional da mandíbula e face dirigindo os movimentos e estimulando a adequação das funções estomatogn

  20. Suicídio atípico com dois ou mais disparos efetivos de arma de fogo: casuística do Instituto Médico Legal de Belo Horizonte e implicações periciais

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    Leonardo Santos Bordoni

    2017-05-01

    Full Text Available O Brasil ocupou o oitavo lugar em números absolutos de suicídios no mundo em 2012. Apesar do suicídio com arma de fogo (AF não ser a modalidade mais comum, é frequente seu encontro na prática pericial criminal. Na maioria dos suicídios com AF há apenas um disparo efetivo e o encontro de duas ou mais lesões de entrada classifica o suicídio como atípico. Neste estudo foram avaliados os suicídios atípicos com dois ou mais disparos efetivos de AF nas necropsias do Instituto Médico Legal de Belo Horizonte realizadas entre 2006 e 2012. Foram resgatados cinco casos, correspondendo a 2,63% do total de suicídios com AF autopsiados no período estudado. A maioria dos casos era do sexo masculino, solteira, tinha pele morena, apresentava idade média de 42,3 anos e recebeu atendimento médico previamente ao óbito. Em quatro casos foram observadas duas lesões de entrada de projéteis de AF e em apenas um foram observadas três. Todos apresentavam lesões de entrada no tórax, a maioria localizada na região peitoral esquerda. Em dois indivíduos houve lesões de entrada no tórax e na cabeça. A causa da morte da maioria foi traumatismo torácico perfuro-contuso. Apesar da necropsia forense ser crucial no estabelecimento da causa médica da morte e na avaliação da capacidade de desempenhar atos motores voluntários após um primeiro disparo, a investigação criminal de casos de suicídios atípicos é um trabalho multidisciplinar, onde cada uma das peças periciais deve se encaixar adequadamente para o estabelecimento correto da causa jurídica da morte.

  1. Fatores prognósticos do trauma raquimedular por projétil de arma de fogo em pacientes submetidos a laminectomia Prognostic factors related to gunshot wounds to the spine in patients submited to laminectomy

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    LEANDRO PRETTO FLORES

    1999-09-01

    Full Text Available Os traumas sobre a coluna resultantes de projetil de arma de fogo (PAF são lesões geralmente graves e muitas vezes com baixo potencial para recuperação neurológica. A indicação cirúrgica destas lesões ainda é motivo de controvérsia. O objetivo deste artigo é identificar fatores no pré e trans-operatório que irão influenciar na recuperação neurológica destes pacientes. Realizamos estudo retrospectivo de 45 pacientes submetidos a laminectomia para trauma raquimedular por PAF, avaliando os seguintes fatores: nível da lesão, apresentação clínica, uso de glicocorticóide no pré-operatório, presença de lesão dural, momento cirúrgico e relação entre escala de Frankel pré e pós-operatória. Observamos que os fatores mais importantes para a recuperação neurológica foram o nível da lesão (53% dos pacientes com lesão lombar melhoraram após a cirurgia e a apresentação clínica pré-operatória (pacientes com síndrome de cauda equina obtiveram melhora em 60% dos casos, sendo que as demais variáveis não apresentaram significância estatística. Em 71% dos casos, a dor pré-operatória foi aliviada com o procedimento cirúrgico.The spinal trauma related to civilian gunshot missile still remains a serious neurological event that carries a dismal prognosis almost in all cases. Its surgical indication also is a mather of discution. Our goal is to identify the aspects that could influence the prognosis after surgery to this kind of lesions. We conducted a retrospective study of 45 consecutive patients submitted to laminectomy at Hospital de Base do Distrito Federal (Brasília, Brazil, testing the following aspects: initial neurological status, level of the deficit, surgical timing, use of methilprednisolone and presence of dural tearing. Among those, the initial clinical presentation and the level of the lesion (60% of the patients with cauda equina syndrome and 53% of that with lesions in the lombar region improved

  2. Traumatismo cranioencefálico por projétil de arma de fogo: experiência de 16 anos do serviço de neurocirurgia da Santa Casa de São Paulo

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    Rodrigo Becco de Souza

    2013-08-01

    Full Text Available OBJETIVO: avaliar os aspectos epidemiológicos e fatores prognósticos associados a uma série de pacientes vítimas de traumatismo cranioencefálico por projétil de arma de fogo (PAF. MÉTODOS: Foram revisados os prontuários de 181 pacientes da Disciplina de Neurocirurgia da Santa Casa de São Paulo com diagnóstico de traumatismo cranioencefálico (TCE decorrente de agressão por PAF no período de janeiro de 1991 a dezembro de 2005. Foram avaliados: idade, sexo, pontuação na escala de coma de Glasgow (ECG à admissão, região encefálica acometida pelo PAF, tipo de lesão (penetrante ou tangencial, tipo de tratamento realizado e resultado ou desfecho, baseado na Escala de coma de Glasgow. A relação entre estratégia terapêutica e o resultado final foi analisada pelo teste Chi-quadrado de Pearson com correção de Yate. O teste de Fisher foi utilizado para verificar a mesma correlação individualmente para cada grupo estratificado pela ECG à admissão. RESULTADOS: Na nossa série de 181 pacientes, 85% eram do sexo masculino (n=154 e 15%, do sexo feminino (n=27. A média de idade foi 31,04 anos (+/- 10,98. A principal região encefálica acometida foi o lobo frontal (27,6%, seguido pelo temporal (24,86% e occipital (16,57%. Dos TCE avaliados, 16% eram tangenciais e 84% penetrantes. CONCLUSÃO: Os pacientes submetidos ao tratamento cirúrgico evoluíram melhor do que os submetidos ao tratamento conservador, e os pacientes que se apresentam mais graves à admissão (com ECG entre 3-8 apresentam melhores resultados com o procedimento neurocirúrgico.

  3. DISEASES

    DEFF Research Database (Denmark)

    Pletscher-Frankild, Sune; Pallejà, Albert; Tsafou, Kalliopi;

    2015-01-01

    Text mining is a flexible technology that can be applied to numerous different tasks in biology and medicine. We present a system for extracting disease-gene associations from biomedical abstracts. The system consists of a highly efficient dictionary-based tagger for named entity recognition...... of human genes and diseases, which we combine with a scoring scheme that takes into account co-occurrences both within and between sentences. We show that this approach is able to extract half of all manually curated associations with a false positive rate of only 0.16%. Nonetheless, text mining should...... not stand alone, but be combined with other types of evidence. For this reason, we have developed the DISEASES resource, which integrates the results from text mining with manually curated disease-gene associations, cancer mutation data, and genome-wide association studies from existing databases...

  4. The influence of fire regime on microscale structural variation and patchiness in Cerrado vegetation. A influência do regime de fogo na variação estrutural em microescala e o mosaico da vegetação de Cerrado.

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    Giselda DURIGAN

    2010-06-01

    Full Text Available O fogo é um dos principais condicionantes do mosaico fisionômico da vegetação do Cerrado, em diferentes escalas. O objetivo do presente estudo foi explorar o mosaico estrutural da vegetação do Cerrado em microescala, em áreas com diferentes regimes de fogo, no mosaico formado pelas unidades de conservação Estação Ecológica e Floresta Estadual de Assis, SP. Analisamos a vegetação em quatrotransectos com 80 m de extensão, divididos em 20 subamostras de 4 m de comprimento. Para estimar a cobertura de todas as espécies do estrato herbáceo, utilizamos o método de intercepção de linhas em três diferentes faixas de altura: 0-50 cm, 50-100 cm e 100-150 cm. Medimos e identificamos todas as árvores e arbustos presentes nas subparcelas de 4 m x 4 m e coletamos amostras de solo compostas em cada transecto para caracterização ambiental. Comparamos os valores médios de cobertura e densidade da vegetação nos diferentes estratose efetuamos análises multivariadas para explicar as diferenças florísticas entre as comunidades. Os resultados indicam que o fogo induz aumento na heterogeneidade, especialmente nos estratos inferiores da vegetação. No entanto, não há diferenciação florística que possaser explicada pelos diferentes regimes de incêndios ou diferenças edáficas. Palavras chave: savana; influência do fogo; estrutura da comunidade;mosaico vegetacional.Fire can produce a hierarchical pattern of vegetation patchiness, from the large, landscape scale to the microscale, the dynamic nature of which changes over time. The aim of this study was to explore the microscale structural patchiness of Brazilian savanna vegetation (cerrado in areas with different fire regimes at the mosaic formed by Assis Ecological Station, and Assis State Forest,SãoPauloState.Vegetation was analysed in 80 m transects divided into twenty 4 m length plots that were established in four areas of savanna. The line-intercept method was used to estimate

  5. Influências de Atta spp. (Hymenoptera: Formicidae na recuperação da vegetação pós-fogo em floresta de transição amazônica Influences of leafcutter ant Atta spp. (Hymenoptera: Formicidae on vegetation recovery after fire in Amazonian transitional forest

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    Karine Santana Carvalho

    2012-03-01

    Full Text Available Este estudo investigou o papel das saúvas na recuperação da vegetação pós-fogo. Foi hipotetizado que a perturbação do fogo aumenta a abundância de ninhos de saúva (1 e as atividades de remoção de sementes (2 e desfolha (3, especialmente no ambiente de borda. Os ninhos de saúva foram inventariados e mapeados e após 17 meses, checados para o registro de sua atividade e de novas colônias emergindo na área. Realizou-se experimentos comparativos de remoção de sementes e desfolha de plântulas em duas parcelas de 50 ha, uma submetida a fogo anual (tratamento e outra sem fogo (controle. A abundância de ninhos de saúva foi maior na parcela tratamento que na parcela controle, especialmente na borda da floresta. As espécies encontradas foram: Atta cephalotes, A. laevigata e A. sexdens , sendo esta última a espécie mais abundante e que mostrou aumento em número de colônias ativas após 17 meses. O aumento na abundância de ninhos na parcela tratamento foi acompanhado por um aumento na atividade dessas formigas. Enquanto mais de duas folhas foram arrancadas por plântula nessa parcela, menos de uma foi registrada na parcela controle. Também a abundância média de galhos desfolhados e de sementes removidas por saúvas foi maior na parcela tratamento que na parcela controle. As saúvas tanto podem diminuir ou retardar o processo de regeneração florestal pós-fogo, quanto acelerá-lo, devido à elevada predação seletiva que favorece as espécies menos palatáveis. Desta forma, suas atividades podem modificador apenas a composição da vegetação recuperando-se do fogo.In this study we investigated the role of leaf-cutting ants in the post-fire vegetation recovery. We hypothesized that a forest plot submitted to annual fire presents: (1 higher abundance of leaf-cutting ant nests; (2 higher removal of seeds; and (3 higher herbivory rates of leaf-cutting ants, when compared to the forest plots without fire (control. The leaf

  6. Post-fire flowering and fruiting in Vellozia sincorana, a caulescent rosette plant endemic to Northeast Brazil Floração e frutificação depois de fogo em Vellozia sincorana, planta caulescente de roseta endêmica do Nordeste do Brasil

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    Abel Augusto Conceição

    2012-03-01

    outubro de 1999 suscitou as seguintes perguntas: O fogo afeta a floração e frutificação de V. sincorana? A altura dos indivíduos é correlacionada com a produção de flores e frutos? Um incêndio em 08 de novembro de 2008 foi oportuno para explorar essas questões. Foram monitoradas populações de V. sincorana em duas áreas de campos rupestres em morros no Parque Nacional da Chapada Diamantina (12º31'S - 41º29'W; 12º36'S - 41º28'W, uma acometida pelo incêndio de novembro de 2008 e a outra não queimada desde 1999. Em ambas as áreas, 25 indivíduos foram sorteados e monitorados. Os números de flores e frutos foram contados e as alturas das plantas foram medidas em nove amostragens realizadas entre 2008 e 2010. Correlação de Spearman e regressão linear foram utilizadas para avaliar a relação entre altura dos indivíduos e a fenologia. Floração e frutificação ocorreram apenas na população queimada a menos tempo, cerca de 40 dias depois do fogo e em 24 dos 25 indivíduos monitorados (96%. A quantidade de flores e/ou frutos foi positivamente e significativamente correlacionada com a altura das plantas. A abundante floração depois do incêndio é um indicativo do fogo como fator que dispara essa fase fenológica. Estimativa da idade de indivíduos altos e eventos de floração podem ser utilizados para estimar a frequência do fogo em áreas de populações de V. sincorana, contribuindo para o conhecimento da ecologia do fogo e para conservação biológica e manejo do fogo nos campos rupestres.

  7. Rehabilitation practices in a burned Araucaria Forest patch: partial results Ações de recuperação em área degradada por fogo em Floresta Ombrófila Mista: resultados parciais

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    Nelson Carlos Rosot

    2010-06-01

    Full Text Available

    This study describes the initial measures taken to reconstitute the forest cover in a burned area of Araucaria Forest by means of planting seeds and seedlings of Araucaria angustifolia (parana pine and Ocotea porosa (imbuia. The study area is located at the Experimental Station of Caçador, in Caçador, State of Santa Catarina, Brazil. Species were systematically arranged in lines and rows over the experimental area and a spacing of 5 x 5 m between trees belonging to the same species was adopted. There were planted 123 parana-pines and 96 imbuias. Thirty-five trees, which remained after the fire, were also left in the area. Parana-pines were firstly planted by seed, but due to the attack of Cebus apella nigritus on the newly emerged plants, it was necessary to replant them using seedlings. Imbuias were planted using seedlings and some damages due to ants and caterpillars were observed. At the present phase of the research, survival analyses are being performed, as well as the collection of data for a Geographic Information System. Next steps will include sampling of natural regeneration of tree species of economic importance occurring in the same area.

    O presente trabalho relata as ações iniciais desenvolvidas em um   remanescente de Floresta com Araucária, que sofreu perturbação por  fogo, no qual se pretende favorecer a recomposição da cobertura  florestal por meio do plantio de sementes e mudas de Araucaria  angustifolia (pinheiro e Ocotea porosa (imbuia. A área de estudo  localiza-se na Estação Experimental de Caçador, Município de Caçador,  SC. A distribuição das espécies sobre a área ocorreu de  forma sistemática, com o plantio em linhas, respeitando-se o  espaçamento de 5 m x 5 m entre indivíduos de mesma espécie.  Foram plantados na área 123 indivíduos de araucária e 96 de imbuia,  somandose aos 35 indivíduos adultos remanescentes. Para a  arauc

  8. Estudo epidemiológico dos traumas raquimedulares por projétil de arma de fogo no hospital geral do estado da Bahia Estudio epidemiológico del trauma de la médula espinal por proyectil de arma de fuego en el hospital geral do estado da Bahia Epidemiological study of trauma of spinal cord trauma by a projectile of firearm in the hospital geral do estado da Bahia

    OpenAIRE

    Maurício Guimarães Pimentel; Eduardo Gil França Gomes; Maurício Santos Gusmão; Djalma Castro de Amorim Junior; Marcus Thadeu Venâncio Simões; Joilda Fontes Gomes; Jayme Batista Freire; Joseph Azulay; Adauto José Santos Pedreira; Orlando Espinheira Freire de Carvalho Filho; Sérgio Murilo Andrade; Rony Brito Fernandes

    2012-01-01

    OBJETIVO: Realizar um levantamento de dados epidemiológicos em prontuários, avaliando a evolução neurológica dos pacientes vítimas de lesões por arma de fogo na coluna vertebral durante a internação hospitalar, que foram operados entre 1991 e 2010. MÉTODOS: Os dados foram tabulados por meio de estatística descritiva, buscando significância estatística entre a melhora neurológica e o procedimento cirúrgico individualizado para cada caso. Dos 290 pacientes operados, 115 deram entrada no HGE com...

  9. Ferreira Gullar: o fogo procura sua forma

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    Viviana Bosi

    Full Text Available Resumo O presente estudo aborda dois aspectos interligados da trajetória de Ferreira Gullar: ora o questionamento em relação à poesia, ora a interrogação sobre o tempo. Desde o início de sua obra, o hiato entre mundo e palavra é constantemente problematizado, assim como a passagem da vida, em sua ocorrência fugaz, para a matéria perene do poema. Esse conflito manifesta-se não apenas na temática, mas também na formalização mesma do poema. Por vezes, a tensão resultante entre arte e vida leva à insatisfação do poeta contra suas próprias realizações. Depois de percorrer diferentes momentos da produção de Gullar, e tendo comentado como o Poema sujo tenta aprofundar essa reflexão, conclui-se que houve uma relativa transformação nos últimos livros do poeta, quando ele parece se aproximar de uma tentativa de conciliação entre a composição artística e a transitoriedade do tempo presente.

  10. Caracterização das vítimas de ferimentos por arma de fogo, atendidas pelo Serviço de Atendimento Móvel de Urgência em Campo Grande-MS Characterization of victims injured by firearms assisted by the Mobile Emergency Care Service in Campo Grande-MS

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    Simone Sanches

    2009-03-01

    Full Text Available A violência, em todas as suas apresentações, tem crescido de forma avassaladora no país, elevando os indicadores de morbidade e mortalidade por causas externas. O uso das armas de fogo, muitas vezes, faz vítimas fatais ou que podem permanecer sequeladas. Tal fato tem aumentado o ônus do estado com internações hospitalares e acréscimo dos anos de vida perdidos da população jovem, que constitui a grande maioria dessas vítimas. Nesse sentido, o presente estudo objetivou fazer um levantamento das vítimas de ferimentos por arma de fogo, atendidas pelo Serviço de Atendimento Móvel de Urgência no município de Campo Grande-MS, no período de abril de 2005 a abril de 2007, nos dois primeiros anos de funcionamento, desde a implantação desse serviço na capital do Estado de Mato Grosso do Sul. Realizou-se estudo descritivo, baseado em análise documental do sistema de informação do SAMU do município de Campo Grande-MS. Foram descritos 233 atendimentos. Os resultados evidenciaram 213 vítimas do sexo masculino, a faixa etária mais acometida foi dos 20 aos 24 anos de idade, a cabeça e o pescoço foram as partes do corpo mais atingidas e a região Sul do município de Campo Grande foi a que concentrou maior número de atendimentos. Conclui-se que a violência por arma de fogo em Campo Grande-MS atinge a camada economicamente ativa da população e provém de regiões de bolsões de pobreza e desigualdade social, justificando a implantação de um serviço como o SAMU.Violence has grown in an overwhelming way in Brazil, raising the indicators of morbidity and mortality by external causes. Many times, the use of firearms makes fatal victims or victims who may remain disabled. This fact has increased the State's onus regarding hospital costs and also the number of life years that the young population loses, as it forms the majority of the victims. The present study aimed to survey the victims of injuries caused by firearms, assisted by

  11. Direito e sociedade na Amazônia: sobre a proibição legal do uso do fogo em atividades econômicas agropastoris Law and society in the Amazon: the legal prohibition on the use of fire in agropastoral economic activities

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    David Wilson de Abreu Pardo

    2012-12-01

    Full Text Available Análise de conflito socioambiental causado pelo uso do fogo em atividades econômicas agropastoris na amazônia, com o objetivo de oferecer tratamento jurídico para a problemática, construindo o argumento a partir do nível da lei e passando ao nível dos direitos e da Constituição, inserindo neste os temas da economia e da cultura. Procedimento de análise e tratamento dos argumentos e interesses dos atores tais quais reconstruídos, sugerindo a resolução do ponto de vista do direito como prática social, com enfoque crítico e contextualizado. Discussão do problema ilustrada com dados de um processo de ação civil pública proposta pelo Ministério Público no Acre. Plano de trabalho com descrição inicial do problema das queimadas na Amazônia. Depois, reflexão sobre o sentido da lei florestal e regulação administrativa da prática. Finalmente, exame do argumento constitucional, refutando contestações da economia e da cultura. Conclusão pela cessação das queimadas como técnica de produção econômica na Amazônia, excetuando o uso restrito e controlado do fogo na agricultura de subsistência praticado por populações tradicionais e indígenas.Analysis of environmental conflict caused by the use of fire in agropastoral economic activities in the Amazon. Purpose of providing legal treatment for the problem, building the argument from the level of the law and passing the level of rights and the constitution by inserting in the themes of economy and culture. Procedure for analysis and processing of arguments and interests of actors, such as they rebuilt, suggesting the resolution of the point of view of law as a social practice, focusing on critical and contextualized. Discussion of the problem illustrated with data from a process of public civil action filed by prosecutors in acre. Work plan with the initial description of the problem of fires in the Amazon. Then reflect on the meaning of the forestry law and administrative

  12. Traumatismo raquimedular por ferimento de projétil de arma de fogo: avaliação epidemiológica Traumatismo raquimedular por herida de un proyectil de arma de fuego: la evaluación epidemiológica Spinal cord trauma by a firearm projectile: epidemiological assessment

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    Francisco Alves de Araújo Júnior

    2011-01-01

    Full Text Available OBJETIVO: Avaliar a incidência de trauma raquimedular causado por projétil de arma de fogo nos pacientes atendidos no pronto socorro de um hospital de Curitiba (PR. MÉTODOS: Estudo retrospectivo, realizado no período de fevereiro de 2005 a julho de 2008, incluindo todos os pacientes, vitimas de lesão na coluna vertebral causada por projétil de arma de fogo (n = 54. RESULTADOS: A grande maioria dos pacientes acometidos é do sexo masculino e em idade produtiva, com média de 27,18 anos. O segmento mais afetado foi a coluna torácica, com ferimentos transfixantes e lesão ASIA A (lesão completa. A maioria dos casos foi tratada de forma conservadora. O período da semana em que houve maior incidência foi o fim e semana, com predomínio do sábado e da sexta-feira. O motivo mais comum foi assalto. CONCLUSÃO: São lesões com alto impacto no custo de saúde pública e de previdência, uma vez que são lesões de alta taxa de morbidade e acometimento predominante de pessoas em faixa etária produtiva.OBJETIVO: Evaluar la incidencia del traumatismo raquimedular causado por proyectil de arma de fuego en pacientes atendidos en la sala de emergencias de un hospital en Curitiba (Paraná. MÉTODOS: Estudio retrospectivo, realizado en el período de febrero 2005 a julio de 2008, incluyendo a todos los pacientes víctimas de lesión medular en la columna vertebral causada por un proyectil de arma de fuego (n = 54 pacientes. RESULTADOS: La gran mayoría de los pacientes son varones y en edad de trabajar, con un promedio de 27,18 años. El sector más afectado ha sido la columna torácica, con heridas transfixiantes y ASIA A (lesión medular completa. La mayoría de los casos fue tratada de forma conservadora. El período de la semana, donde había una mayor incidencia fue el fin de semana, con predominio del sábado y el viernes. La razón más frecuente fue por asalto. CONCLUSIÓN: Se trata de lesiones con un alto impacto en el costo de la salud p

  13. Impacto do fogo no componente arbóreo de uma floresta estacional semidecídua no município de Ibituruna, MG, Brasil Impact of fire on the arboreal component of a seasonal semideciduous forest in Ibituruna, southeastern Brazil

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    Vagner Fernandes da Silva

    2005-12-01

    Full Text Available Foram realizados inventários da comunidade arbórea, da topografia e dos solos de um fragmento de floresta semidecídua com o objetivo de avaliar os impactos de um incêndio ocorrido em 1999, na estrutura da comunidade arbórea e na composição e diversidade de espécies, bem como as relações entre a severidade do incêndio e variáveis do ambiente físico. O fragmento florestal, com área de 57 ha, está localizado nas coordenadas de 21º09'S e 44º50'W, no município de Ibituruna, MG. Os inventários foram conduzidos em dois setores do fragmento. Na Encosta, foram realizados dois inventários: o primeiro, em 1997, antes do incêndio, foi feito em quinze parcelas de 5×50 m e o segundo, em 2001, posterior ao incêndio, em treze parcelas de 20×20 m. No Vale, foi conduzido em 2001 um inventário em 13 parcelas de 20×20 m distribuídas ao longo da linha de frente definida pela propagação máxima do incêndio. Nos inventários foram registradas a espécie, a circunferência à altura do peito (CAS e a altura total de todos os indivíduos arbóreos com diâmetro à altura do peito (DAP > 5 cm. Em cada parcela, foram obtidas variáveis topográficas, variáveis químicas e texturais do solo e gerados um fator borda e um índice de dano por fogo (IDF. O incêndio causou impactos consideráveis ao componente arbóreo da vegetação. A densidade e a área basal total de indivíduos arbóreos foram reduzidas e esta redução concentrou-se nas classes de menores diâmetros e alturas. Onde o incêndio foi mais severo (maior IDF, foram maiores as proporções de árvores mortas em pé em relação às sobreviventes, expressas tanto em densidade como em área basal. Na Encosta, as espécies que atingem menor porte na maturidade caíram na ordem de abundância relativa depois do fogo. Dois anos após o incêndio houve aumento na diversidade e riqueza de espécies de árvores provavelmente devido ao acréscimo de espécies pioneiras nas áreas abertas

  14. Dermatoses bolhosas auto-imunes Autoimmune bullous dermatoses

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    Paulo R. Cunha

    2009-04-01

    Full Text Available Dermatoses bolhosas autoimunes são doenças cuja manifestação cutânea primária e fundamental consiste em vesículas e bolhas. Classificam-se conforme a localização da bolha, em intraepidérmica e subepidérmica. Os pacientes produzem autoanticorpos contra estruturas específicas da pele detectáveis por técnicas de imunofluorescência, immunobloting e Elisa. Os recentes avanços da biologia molecular e celular têm permitido conhecer esses autoantígenos, contra os quais os pacientes se sensibilizam e que estão localizados na epiderme ou na junção dermoepidérmica. São doenças de baixa incidência, porém de elevada morbidade e por vezes letais. O objetivo deste trabalho é revisar e descrever os progressos nos conhecimentos de quatro doenças vésico-bolhosas autoimunes: pênfigo foliáceo endêmico (fogo selvagem, pênfigo vulgar, penfigóide bolhoso e dermatite herpetiforme.Autoimmune bullous dermatoses are diseases in which blisters and vesicles are the primary and fundamental types of skin lesion. Their classification is based on the location of the blister: intraepidermal and subepidermal. Patients produce autoantibodies against self-specific structures of the skin detectable by immunofluorescence techniques, immunoblotting and ELISA. Recent advances in molecular and cellular biology have brought to knowledge these self-antigens, against which patients are sensitized, and which are found in epidermis or in the dermo-epidermal junction. These are low incidence, but high morbidity diseases that may be fatal. The aim of this article is to review and describe the progress of four autoimmune vesiculobullous disorders: endemic pemphigus foliaceous (wild fire, pemphigus vulgaris, bullous pemphigoid and dermatitis herpetiformis.

  15. Estudo retrospectivo de janeiro de 1998 a maio de 2005, no Hospital Universitário de Maringá, sobre ferimentos por arma branca e arma de fogo = Retrospective study (january 1998 / may 2005 at the University Hospital of Maringá, on wounds caused by edged weapons and firearms

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    Marco Aurélio Valadão Fagundes

    2007-07-01

    Full Text Available O objetivo deste trabalho é determinar as características dos pacientes atendidos no Hospital Universitário de Maringá (HUM, com ferimento por arma branca (FAB e por arma de fogo (FAF, quanto ao sexo, idade, às regiões corporais, órgãos mais atingidos, tempo de internamento, complicações e mortalidade. Após análise de uma planilhaelaborada para a pesquisa, observou-se que 68% dos atendimentos foram por FAB e 32%, por FAF, sendo a maioria homens (mais de 90%, adultos jovens (2ª e 3ª década, por FAF e FAB, respectivamente. As regiões mais acometidas foram abdome e tórax. e os órgãos mais atingidos foram intestino delgado e fígado, na lesão por arma branca, e fígado e intestino delgado, no FAF. A complicação mais comum foi o choque hipovolêmico. Concluiu-se que os FAB ocorreram em maior número no sexo masculino, na terceira década de vida.The objective of this study is to determine the characteristics of patients assisted at the University Hospital of Maringá (HUM with wounds from edged weapons (EWW or firearms (FW, in regards to gender, age, wounded body areas, most affected body organs,length of hospitalization, complications and mortality rates. After the analysis of a worksheet elaborated for the study, it was observed that 68% of admissions had been for EWW and 32% for FW. The majority were men (90% and young adults (20s and 30s, for FW and EWW, respectively. The most affected body areas were the abdomen and thorax, and the most wounded organs were, in order: the small intestine and liver for EWW, and the liver and small intestine for FW. The most common complication was hypovolemic shock. It was concluded that EWW had occurred in larger numbers than FW, withpredominance in males in their 30s.

  16. MAST CELLS, MAST/STEM CELL GROWTH FACTOR RECEPTOR (C-KIT/CD117 AND IGE MAY BE INTEGRAL TO THE PATHOGENESIS OF ENDEMIC PEMPHIGUS FOLIACEUS

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    Ana Maria Roselino

    2013-11-01

    Full Text Available Introduction: Pemphigus foliaceus (PF is endemic in some South American countries, especially in Colombia and Brazil; in Brazil, it is also known as fogo selvagem (FS. We aimed to study the presence of mast cells and the expression of the mast/stem cell growth factor receptor (c-kit/CD117 in PF skin biopsies, as well as the role of IgE in the disease pathogenesis. Methods: Forty-four skin biopsies from patients affected by endemic PF (EPF (30 patients from El Bagre, Colombia, and 14 from the northeastern region of São Paulo State, Brazil, 48 control biopsies from Colombian and Brazilian endemic areas, and additional control biopsies from none endemic areas in Colombia and the USA non were studied. Immunohistochemistry (IHC was performed to evaluate skin biopsies with anti-mast cell tryptase (MCT, anti-c-kit and anti-IgE antibodies. We also searched for serum IgE in 30 EPF and 30 non-atopic controls from the El Bagre region via ELISA. In our El Bagre patients and controls, we also searched for IgE in skin samples by direct immunofluorescence. Results: In 100% of the EPF biopsies, MCT, c-kit and IgE were identified with stronger expression relative to control biopsies, especially in the inflammatory infiltrates around upper dermal blood vessels and dermal eccrine glands. IgE staining was positive along the BMZ in some EPF skin samples. The DIF results confirmed a linear deposition of IgE at the BMZ. Increased IgE serum levels were also noted in PF patients relative to controls.. Conclusions: In patients with EPF, the observed increased expression of MCT, c-kit and IgE in lesional skin, associated with higher serum IgE levels may indicate possible IgE participation in the antigenic response.

  17. Prevalencia y evolución clínica de pacientes con heridas por arma de fuego en la columna vertebral Prevalência e evolução clínica de pacientes com ferimentos por arma de fogo na coluna vertebral Prevalence and clinical course of patients with gunshot wounds to the spine

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    José María Jiménez Avila

    2013-01-01

    estudio. El grado de discapacidad medido mediante la escala de Oswestry inicial mínimo fue de 18 puntos, el máximo de 94, con media de 62 y desviación estándar de 22.2. El Oswestry final tuvo una media de 58 puntos con desviación estándar de 23.5. CONCLUSIONES: En nuestro estudio podemos concluir que las heridas por arma de fuego en la columna, ocasionan un alto grado de discapacidad y evolucionan con alta morbilidad. A esto hay que añadir que tanto el tratamiento clínico cuanto el quirúrgico, no proporcionan mejoría sustancial en el estado neurológico y funcional del paciente. Tan solo se limitan a medidas de soporte para disminuir en lo posible las complicaciones, que a final de cuenta, son las que influenciarán en la calidad y sobrevida de los afectados. La extracción del proyectil y el tiempo transcurrido desde la cirugía no alteran el estado funcional final del paciente.OBJETIVOS: Determinar prevalência, mortalidade e evolução clínica dos pacientes com ferimentos por arma de fogo na coluna vertebral e determinar se a extração do projétil melhora o estado neurológico dos pacientes. MÉTODO: Realizou-se um estudo de série de casos por meio da análise dos prontuários médicos de todos os pacientes com ferimentos por arma de fogo na coluna vertebral, internados na UMAE, Hospital de Especialidades do CMNO do IMSS, de setembro de 2010 a setembro de 2011, que eram compatíveis com os critérios de inclusão, exclusão e não-inclusão. O grau de incapacidade dos pacientes foi medido pelo índice de Oswestry. RESULTADOS: O grupo foi formado por 13 (86,7% pacientes do sexo masculino e 2 (13,3% do sexo feminino, com média de idade de 42 anos e desvio padrão de 14 anos. As regiões mais afetadas foram torácica 7 (46,7%, cervical 5 (33,3% e, por último, lombar, co 3 (20% pacientes; a permanência no hospital observada com mais frequência foi 7 (13,3% e 10 (13,3% dias com 2 casos cada uma; a permanência hospitalar mínima foi de 3 dias, com apenas

  18. Impactos do fogo sobre o componente arbustivo-arbóreo de um remanescente de Floresta Ombrófila Aberta, Areia, Estado da Paraíba = Impacts of fire on the tree-shrub component in an ombrophilous forest fragment in Areia, Paraíba State

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    Klerton Rodrigues Forte Xavier

    2009-10-01

    Full Text Available O objetivo do presente trabalho foi avaliar os impactos causados pelo fogo sobre o estrato arbustivo-arbóreo de um fragmento de Floresta Atlântica, em Areia, Paraíba. Foram plotadas 40 parcelas de 100 m2 em dois ambientes: floresta intacta (Ambiente I e floresta queimada (Ambiente II. O presente levantamento incluiu indivíduos com diâmetro ao nível do solo (DNS ≥ 3 cm, sendo a estrutura da vegetação avaliada por parâmetros convencionais. Calcularam-se, também, os índices de diversidade e de equabilidade, além da similaridade entre os ambientes. Foram amostrados 1.960 indivíduos, pertencentes a 22 famílias, 26 gêneros e 35 espécies. No Ambiente I, Protium heptaphyllum foi a espécie mais abundante e importante; noAmbiente II, sobressaíram-se os indivíduos mortos. O teste Kruskal-Wallis (H analisou a diferença no número de perfilhos dos indivíduos entre os Ambientes, apontando diferença significativa entre estes. O índice de diversidade e a equabilidade no Ambiente I foram maioresque no atingido pelo incêndio; pelo índice de Jaccard, porém, verificou-se que continuam similares. Os resultados demonstraram que o incêndio parece não modificar a composição específica da sinúsia, mas afeta a estrutura da comunidade, além de aumentar significativamente o perfilhamento, indicando a morte da parte aérea de muitos indivíduos.The objective of this study was to evaluate the impacts of fire on the tree-shrub component in an ombrophilous forest fragment in Areia, state of Paraíba, Brazil. Forty parcels were plotted in two environments: intact forest (Environment I and burned forest(Environment II. The vegetation structure was evaluated by conventional parameters, and the difference in the number of shoots of individuals between the environments was evaluated using the Kruskal-Wallis test. Also calculated were the index of diversity, equability and the similarity between the environments. We sampled 1,960 individuals

  19. Brasil: a economia do capitalismo selvagem Brazil: the economics of savage capitalism

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    Regis de Castro Andrade

    2002-01-01

    Full Text Available Originalmente publicado em 1981 na publicação que precedeu Lua Nova e no ano seguinte na Inglaterra (em Gienefel, M. e Godfrey, M., ed., The Struggle for Development - National Strategies in an International Context. London, Wiley, este artigo traça um retrato da economia brasileira da perspectiva do início dos anos 80. Analisa a formação e as características do "modelo brasileiro", examina o boom de 1968-1973 (o "milagre brasileiro" e assinala a emergência de uma nova etapa, em que fatores externos à economia nacional passariam a preponderar. Sustenta que o novo período seria marcado por tensões agudas, em parte porque o sistema político não seria capaz de assimilar os problemas econômicos.Originally published in 1981, in the periodical preceding Lua Nova and in England the next year (in Gienefil, M. and Godfrey, M., ed., The Struggle for Development - National Stratregies in an International Context. London, Wiley, this article draws a picture of the Brazilian economy from de point of view of the early 80's. The construction and the features of the "brazilian model" as well as the boom of 1968-73 (the "brazilian miracle" are analyzed, and the emergence of a new stage with external factors at the forefront is pointed out. The author holds that the new period would be marked by acute tensions, partly due to the inability of the political system to tackle the economic problems.

  20. ENTRE O BOM E O MAU SELVAGEM: FICÇÃO E ALTERIDADE NO CINEMA BRASILEIRO

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    JULIANO GONÇALVES DA SILVA

    2007-12-01

    Full Text Available ABSTRACT: This paper consists in an analysis of the indians image on the brazilian, achieved through the study of how the indian character is built and disseminated through the brazilian fiction films.RESUMO: O artigo realiza uma análise da imagem do índio no cinema brasileiro, através do estudo de como o personagem indígena é por ele construído e veiculado através dos filmes de ficção de longa-metragem.

  1. Luis Buñuel: uma poética do selvagem

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    Eduardo Peñuela Cañizal

    2009-12-01

    Full Text Available This article is an analysis of the effect of rhetorical disruptions at the levels of soundtrack and images inserts in Luis Buñuel’s films. Its main objective consists in detaching fragments of films with the finality of studying the role of a wild poetics

  2. TABAGISMO NA BRONQUIOLITE – ONDE HÁ FUMO HÁ FOGO?

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    Sara Leite

    2015-12-01

    Discussão: A exposição passiva ao fumo do tabaco acarreta maior risco de morbilidade na criança, associada essencialmente a complicações respiratórias. Os autores pretendem alertar os cuidadores e também os profissionais de saúde para a necessidade do reforço de medidas de evicção tabágica, com uma abordagem sistemática durante internamento hospitalar, mas também em regime de consulta.

  3. Estudo epidemiológico dos traumas raquimedulares por projétil de arma de fogo no hospital geral do estado da Bahia Estudio epidemiológico del trauma de la médula espinal por proyectil de arma de fuego en el hospital geral do estado da Bahia Epidemiological study of trauma of spinal cord trauma by a projectile of firearm in the hospital geral do estado da Bahia

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    Maurício Guimarães Pimentel

    2012-12-01

    Full Text Available OBJETIVO: Realizar um levantamento de dados epidemiológicos em prontuários, avaliando a evolução neurológica dos pacientes vítimas de lesões por arma de fogo na coluna vertebral durante a internação hospitalar, que foram operados entre 1991 e 2010. MÉTODOS: Os dados foram tabulados por meio de estatística descritiva, buscando significância estatística entre a melhora neurológica e o procedimento cirúrgico individualizado para cada caso. Dos 290 pacientes operados, 115 deram entrada no HGE com quadro clínico de paralisia sensitiva e motora, correspondendo a 39,66% do total, sendo os pacientes Frankel A os mais prevalentes da nossa casuística. RESULTADOS: Esses pacientes evoluíram com menor possibilidade de reversão dos déficits neurológicos, com 94,78% não apresentando melhora na alta hospitalar. Os portadores de lesão medular incompleta apresentaram evolução neurológica em 94,59 % dos operados. CONCLUSÃO: Não foi encontrada significância estatística para a melhora neurológica com relação aos procedimentos cirúrgicos realizados nos pacientes vítimas de lesões por arma de fogo na coluna vertebral.OBJETIVO: Realizar un estudio de datos epidemiológicos en las historias clínicas, evaluando la evolución neurológica de los pacientes que han sufrido lesiones de proyectil de un arma de fuego en la columna vertebral durante la hospitalización, que fueron sometidos a cirugía entre 1991 y 2010. MÉTODOS: Se tabularon los datos a través de estadística descriptiva, en busca de significación estadística entre la mejoría neurológica y el procedimiento quir��rgico para cada caso individual. De los 290 pacientes operados, 115 ingresaron en el HGE con cuadro clínico de parálisis sensorial y motor, que representan el 39,66% del total, siendo los pacientes Frankel A los más prevalentes de nuestra serie. RESULTADOS: Estos pacientes evolucionaron con menos posibilidad de reversión del déficit neurológico, y el

  4. Heart Disease

    Science.gov (United States)

    ... type of heart disease you have. Symptoms of heart disease in your blood vessels (atherosclerotic disease) Cardiovascular disease ... can sometimes be found early with regular evaluations. Heart disease symptoms caused by abnormal heartbeats (heart arrhythmias) A ...

  5. Lung disease

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000066.htm Lung disease To use the sharing features on this page, ... fibrosis and sarcoidosis are examples of lung tissue disease. Lung circulation diseases -- These diseases affect the blood vessels ...

  6. Gaucher disease

    OpenAIRE

    POSPÍŠILOVÁ, Iva

    2012-01-01

    This thesis is about the disease called Gaucher disease, or Morbus Gaucher. There is described the history of the disease, various forms of disease, effect of bones, visceral organs, hematological changes, changes in metabolism etc.; differential diagnosis, diagnosis and therapy.

  7. Disquisiciones en torno al portunhol selvagem. Del horror de los profesores a una “lengua pura”

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    Jorge J. Locane

    2015-12-01

    Full Text Available Los Estados-nación latinoamericanos fueron fundados por las élites criollas a partir de una ideología monolingüe que debía organizar también las literaturas nacionales. Frente a este principio, recientemente han comenzado a ganar visibilidad literaturas producidas en zonas de tránsito cultural y lingüístico que cuestionan aquellos órdenes de cuño colonial. Este estudio destaca la importancia de la literatura elaborada en la frontera entre Brasil, Uruguay, Argentina y Paraguay, y pone en evidencia cómo su emergencia, al haber provocado la reacción de voceros de agencias normativas, no deja de problematizar intereses culturales y comerciales. Latin American nation states were founded by creole elites based on a monolingual ideology that should also organize national literatures. In opposition to this principle, literatures produced in areas of cultural and linguistic transit have recently begun to gain visibility questioning those colonial orders. This study highlights the importance of literature produced on the border between Brazil, Uruguay, Argentina and Paraguay and demonstrates how its emergence, having caused the regulatory agencies spokesmen’s reaction, problematizes cultural and commercial interests.

  8. Literatura e Música: o Outro na Europa e o Selvagem na Ópera Il Guarany, de Carlos Gomes

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    Isaías Francisco de Carvalho

    2017-10-01

    Full Text Available O romantismo literário, em suas primeiras manifestações, tem sua marca mais profunda no indianismo, na circundante tentativa de construção identitária da jovem nação brasileira. Essa tarefa também ecoa em outras artes, com destaque para os reflexos indianistas no âmbito musical, em que Carlos Gomes é um dos principais representantes. Diante do deslocamento na construção do espaço desse compositor na música italiana, (recria-se, a partir da influência literária, o “bom selvagem” que se faz necessário para a afirmação identitária do país distante e para o entretenimento da plateia europeia, ávida pelo “exótico”. Assim, o trabalho intenta mostrar o percurso construído por Carlos Gomes até a composição da ópera Il Guarany e a influência exercida pela literatura indianista da época, mais especificamente a obra O Guarani, de José de Alencar. Além disso, enfatiza-se a inferiorização sofrida pelo compositor no contexto europeu e a tentativa de criação de um mito nacional que não perdeu o vínculo com a hegemonia europeia. Toma-se como base teórica, nos campos do literário, da discussão identitária e da historiografia musical, estudos de Alfredo Bosi (1992, Silviano Santiago (1992; 2000, Edward Said (1992, Stuart Hall (2014, Tzetvan Todorov (2010, Lorenzo Mammì (2001, Vasco Mariz (1994 e Maria Alice Volpe (2002; 2004.

  9. A natureza da fotografia na fotografia da natureza: o selvagem, a desmesura e a beleza do mundo

    OpenAIRE

    Cunha Filho, Paulo C.; Farache, Ana

    2010-01-01

    O artigo discute a relação híbrida da fotografia com a natureza, a partir da ideia de que essa relação articula memória e matéria, pela construção imaginária de paisagens e lembranças. A fotografia privilegia a representação do artificial em detrimento do natural. Mas é a representação da grandeza da paisagem e da precariedade do humano diante dela que revela a própria natureza da fotografia, ao pensar em si e sobre todas as coisas.

  10. Antinomias do zoológico humano: sociabilidade selvagem, reality shows e regressão da consciência

    Directory of Open Access Journals (Sweden)

    Francisco Rüdiger

    2008-11-01

    Full Text Available Estuda-se no artigo as articulações ideológicas e sentido histórico dos chamados reality shows na sociedade brasileira contemporânea. Em primeiro, situamos o gênero numa perspectiva histórica, sublinhado suas raí­zes religiosas e populares em conexão com a formação do sistema de poder próprio do Ocidente. Depois, expõem-se alguns aspectos do fenômeno, chamando atenção para sua estrutura interna e seu sentido concreto em nossa organização societária, com base nas suas versões brasileiras. Em terceiro, focamos os textos nas relações de poder que se articulam por meio desses programas, discutindo algumas das várias teorizações a seu respeito. Adiante e continuando a recorrer a matérias de imprensa, procede-se a um julgamento dessas últimas, visando propor uma interpretação histórica de seu significado. A conclusão retorna ao marco inicial e oferece uma visão geral em que talvez se possa pensar melhor o que está em jogo nos reality shows. Palavras-chave reality shows no Brasil, programas de televisão, sociabilidade Abstract This article analyses the ideological connections and historical meaning of the so-called reality shows in the contemporary Brazillian society. At first, we locate this genre in a historical perspective, stressing its religious and popular roots but also the connections between it and the power systems that have built Western World. Secondly, the text expose the main features of this kind of television show, calling attention to its inner structure but also to its meaning in our social organization, making critical remarks about their Brazillian versions. Focusing on the power relations that are articulated in it, we discuss some theories made about them. The historical meaning of these shows in our present circumstances is projected in the fourth stage of the article, that explores some materials extracted from the press. Finally, we return to the larger historical context and offer a general interpretation to think these programs in it. Key words brazillian reality shows, television shows, sociability

  11. Hashimoto's Disease

    Science.gov (United States)

    ... is Hashimoto’s disease? Hashimoto’s disease, also called chronic lymphocytic thyroiditis or autoimmune thyroiditis, is an autoimmune disease. An ... Points to Remember • Hashimoto’s disease, also called chronic lymphocytic thyroiditis or autoimmune thyroiditis, is an autoimmune disease. • Hashimoto’s ...

  12. Kawasaki Disease

    Science.gov (United States)

    Kawasaki disease is a rare childhood disease. It makes the walls of the blood vessels in the ... veins, and capillaries. No one knows what causes Kawasaki disease. Symptoms include High fever that lasts longer ...

  13. Alzheimer Disease

    Science.gov (United States)

    ... CPR: A Real Lifesaver Kids Talk About: Coaches Alzheimer Disease KidsHealth > For Kids > Alzheimer Disease Print A A ... slow it down. When Someone You Love Has Alzheimer Disease You might feel sad or angry — or both — ...

  14. Crohn's Disease

    Science.gov (United States)

    Crohn's disease causes inflammation of the digestive system. It is one of a group of diseases called inflammatory ... small intestine called the ileum. The cause of Crohn's disease is unknown. It may be due to an ...

  15. Crohn disease

    Science.gov (United States)

    ... from doing your everyday activities. You have side effects from medicines you are taking for your condition. Alternative Names Crohn's disease; Inflammatory bowel disease - Crohn's disease; Regional enteritis; Ileitis; ...

  16. Meniere's Disease

    Science.gov (United States)

    ... Meniere's disease can affect your social life, your productivity and the overall quality of your life. Learn ... www.mayoclinic.org/diseases-conditions/menieres-disease/basics/definition/CON-20028251 . Mayo Clinic Footer Legal Conditions and ...

  17. Kawasaki disease

    Science.gov (United States)

    ... lymph node syndrome; Infantile polyarteritis Images Kawasaki's disease - edema of the hand Kawasaki's disease, peeling of the fingertips References Dominguez SR, Anderson MS. Advances in the treatment of Kawasaki disease. Curr Opin Pediatr . 2013;25( ...

  18. Gaucher's Disease

    Science.gov (United States)

    ... of developing the most common variety of Gaucher's disease. Gaucher's disease may increase the risk of: Growth delays ... illness can be difficult, but having a rare disease like Gaucher's may be even harder. Few people know about ...

  19. Huntington's Disease

    Science.gov (United States)

    Huntington's disease (HD) is an inherited disease that causes certain nerve cells in the brain to waste ... express emotions. If one of your parents has Huntington's disease, you have a 50 percent chance of ...

  20. Sever's Disease

    Science.gov (United States)

    ... take place on hard surfaces, such as track, basketball, soccer, and gymnastics. Sever's disease also can result ... diagnosing Sever's disease, some doctors order them to rule out other problems, such as fractures. Sever's disease ...

  1. Celiac Disease

    Science.gov (United States)

    ... digestive problems called inflammatory bowel disease (IBD) or lactose intolerance . And in some cases, a kid won't ... for Kids With Celiac Disease Inflammatory Bowel Disease Lactose Intolerance Are Your Bowels Moving? Indigestion Nut and Peanut ...

  2. Ribbing disease

    Directory of Open Access Journals (Sweden)

    Mukkada Philson

    2010-01-01

    Full Text Available Ribbing disease is a rare sclerosing dysplasia that involves long tubular bones, especially the tibia and femur. It occurs after puberty and is reported to be more common in women. In this article we describe how Ribbing disease can be differentiated from diseases like Engelmann-Camurati disease, van Buchem disease, Erdheim-Chester disease, osteoid osteoma, chronic osteomyelitis, stress fracture, etc.

  3. Bladder Diseases

    Science.gov (United States)

    ... frequent, urgent urination Bladder cancer Doctors diagnose bladder diseases using different tests. These include urine tests, x- ... National Institute of Diabetes and Digestive and Kidney Diseases

  4. Fifth Disease

    Science.gov (United States)

    ... roseola. Fifth disease is sometimes called “slapped cheek disease.” The illness’s bright red rash on the face looks like ... disease Most children and adults who get fifth disease experience only mild illness. They recover completely and have no complications. But ...

  5. Heart Diseases

    Science.gov (United States)

    ... you're like most people, you think that heart disease is a problem for others. But heart disease is the number one killer in the U.S. ... of disability. There are many different forms of heart disease. The most common cause of heart disease is ...

  6. Whipple's Disease

    Science.gov (United States)

    ... more common conditions with similar symptoms, including inflammatory rheumatic disease—characterized by inflammation and loss of function in ... Management Liver Disease Urologic Diseases Endocrine Diseases Diet & Nutrition Blood Diseases Diagnostic Tests La información de la salud en ...

  7. Addison disease

    Science.gov (United States)

    ... amounts of some or all of its hormones ( hypopituitarism ) Autoimmune disorder that affects the nerves and the ... disease) Dermatitis herpetiformis Diabetes Graves disease Hyperthyroidism Hypoparathyroidism Hypopituitarism Immune response Myasthenia gravis Ovarian hypofunction Pernicious anemia ...

  8. Fifth disease

    Science.gov (United States)

    Parvovirus B19; Erythema infectiosum; Slapped cheek rash ... Fifth disease is caused by human parvovirus B19. It often affects preschoolers or school-age children during the spring. The disease spreads through the fluids in the nose and ...

  9. Rh Disease

    Science.gov (United States)

    ... Loss > Birth defects & other health conditions > Rh disease Rh disease E-mail to a friend Please fill ... Rh-negative with a blood test. What is Rh factor? Rh factor is a protein that’s found ...

  10. Binswanger's Disease

    Science.gov (United States)

    ... Craniosynostosis Information Page Creutzfeldt-Jakob Disease Information Page Cushing's Syndrome Information Page Dandy-Walker Syndrome Information Page Deep Brain Stimulation for Parkinson's Disease Information Page Dementia Information ...

  11. Batten Disease

    Science.gov (United States)

    ... Craniosynostosis Information Page Creutzfeldt-Jakob Disease Information Page Cushing's Syndrome Information Page Dandy-Walker Syndrome Information Page Deep Brain Stimulation for Parkinson's Disease Information Page Dementia Information ...

  12. Behcet's Disease

    Science.gov (United States)

    ... Craniosynostosis Information Page Creutzfeldt-Jakob Disease Information Page Cushing's Syndrome Information Page Dandy-Walker Syndrome Information Page Deep Brain Stimulation for Parkinson's Disease Information Page Dementia Information ...

  13. Krabbe Disease

    Science.gov (United States)

    ... Craniosynostosis Information Page Creutzfeldt-Jakob Disease Information Page Cushing's Syndrome Information Page Dandy-Walker Syndrome Information Page Deep Brain Stimulation for Parkinson's Disease Information Page Dementia Information ...

  14. Crohn's Disease

    Science.gov (United States)

    ... prognosis of Crohn's disease in adults. http://www.uptodate.com/home. Accessed June 2, 2014. Smoking and ... cancer surveillance in inflammatory bowel disease. http://www.uptodate.com/home. Accessed June 9, 2014. Inflammatory bowel ...

  15. Addison Disease

    Science.gov (United States)

    ... your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make ... A problem with your immune system usually causes Addison disease. The immune system mistakenly attacks your own tissues, ...

  16. Liver Diseases

    Science.gov (United States)

    Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. There are many kinds of liver diseases: Diseases caused by viruses, such as hepatitis ...

  17. Valve Disease

    Science.gov (United States)

    ... heart valves, valve insufficiency, valve regurgitation, valve stenosis, valvular heart disease Every time your heart beats, blood flows into, ... removed from the market after being linked to heart valve disease. An infection in the lining of the heart's ...

  18. Wilson Disease

    Science.gov (United States)

    Wilson disease is a rare inherited disorder that prevents your body from getting rid of extra copper. You ... extra copper into bile, a digestive fluid. With Wilson disease, the copper builds up in your liver, and ...

  19. Gaucher disease

    Science.gov (United States)

    ... doesn't have the disease is called a silent carrier. The lack of the glucocerebrosidase enzyme causes ... liver Fatigue Heart valve problems Lung disease (rare) Seizures Severe swelling at birth Skin changes

  20. Legionnaire disease

    Science.gov (United States)

    ... features on this page, please enable JavaScript. Legionnaire disease is an infection of the lungs and airways. It is caused by Legionella bacteria. Causes The bacteria that cause Legionnaire disease have ...

  1. Parkinson's Disease

    Science.gov (United States)

    ... messages it needs to move normally. continue What Causes Parkinson's Disease? Experts agree that low dopamine levels in ... or other chemicals. No one knows the exact cause of Parkinson's disease, but we do know that it has ...

  2. Fabry Disease

    Science.gov (United States)

    ... Foundation National Organization for Rare Disorders (NORD) National Tay-Sachs and Allied Diseases Association See all related ... Foundation National Organization for Rare Disorders (NORD) National Tay-Sachs and Allied Diseases Association See all related ...

  3. Canavan Disease

    Science.gov (United States)

    ... Foundation, Inc. Canavan Research Foundation Genetic Alliance National Tay-Sachs and Allied Diseases Association See all related ... Foundation, Inc. Canavan Research Foundation Genetic Alliance National Tay-Sachs and Allied Diseases Association See all related ...

  4. Digestive Diseases

    Science.gov (United States)

    ... Celiac Disease Bowel Control Problems (Fecal Incontinence) Gas Lactose Intolerance Diarrhea Diverticulosis & Diverticulitis Acid Reflux (GER & GERD) More Digestive Disease Topics Children and Teens Acid Reflux (GER & GERD) in Infants Acid Reflux (GER & GERD) in Children & Teens Chronic ...

  5. Gaucher Disease

    Science.gov (United States)

    Gaucher disease is a rare, inherited disorder. It is a type of lipid metabolism disorder. If you have ... affected. It usually starts in childhood or adolescence. Gaucher disease has no cure. Treatment options for types 1 ...

  6. Liver disease

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000205.htm Liver disease To use the sharing features on this page, please enable JavaScript. The term "liver disease" applies to many conditions that stop the ...

  7. Wilson Disease

    Science.gov (United States)

    ... in copper, such as –shellfish –liver –mushrooms –nuts –chocolate • A person cannot prevent Wilson disease; however, people with a family history of Wilson disease, especially those with an affected ...

  8. Chagas Disease

    Science.gov (United States)

    Chagas disease is caused by a parasite. It is common in Latin America but not in the United ... There are no vaccines or medicines to prevent Chagas disease. If you travel to areas where it occurs, ...

  9. Legionnaires' Disease

    Science.gov (United States)

    ... Disease Sources Investigation Protocol Outbreak Response What is Legionella? Exposure and Transmission Disease Symptoms Incidence and Risk ... form of pneumonia. More than 43 species of Legionella have been identified and more than 20 linked ...

  10. Heart Disease

    Science.gov (United States)

    ... daily aspirin to prevent heart attack? Does taking birth control pills increase my risk for heart disease? Does using ... tells you to. Return to top Does taking birth control pills increase my risk for heart disease? Taking birth ...

  11. Liver Disease

    Science.gov (United States)

    ... stay still. Liver disease has many causes. Infection Parasites and viruses can infect the liver, causing inflammation ... beyond. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/ ...

  12. Kidney Diseases

    Science.gov (United States)

    ... until you go to the bathroom. Most kidney diseases attack the nephrons. This damage may leave kidneys ... medicines. You have a higher risk of kidney disease if you have diabetes, high blood pressure, or ...

  13. Eye Diseases

    Science.gov (United States)

    ... the back of the eye Macular degeneration - a disease that destroys sharp, central vision Diabetic eye problems ... defense is to have regular checkups, because eye diseases do not always have symptoms. Early detection and ...

  14. Parasitic Diseases

    Science.gov (United States)

    ... water, a bug bite, or sexual contact. Some parasitic diseases are easily treated and some are not. Parasites ... can be seen with the naked eye. Some parasitic diseases occur in the United States. Contaminated water supplies ...

  15. Kawasaki Disease

    Science.gov (United States)

    ... Life7. Questions8. Resources What is Kawasaki disease? Kawasaki disease is a rare illness. It can occur in infants and children younger ... may have diarrhea, vomiting, and stomach pain. Kawasaki disease might make your child irritable. The illness can last for a few weeks. What causes ...

  16. Lyme Disease.

    Science.gov (United States)

    Taylor, George C.

    1991-01-01

    This overview of the public health significance of Lyme disease includes the microbiological specifics of the infectious spirochete, the entomology and ecology of the ticks which are the primary disease carrier, the clinical aspects and treatment stages, the known epidemiological patterns, and strategies for disease control and for expanded public…

  17. [Gaucher Disease].

    Science.gov (United States)

    Okuyama, Torayuki

    2015-09-01

    Gaucher disease is an autosomal recessive disorder caused by congenital deficiency of lysosomal glucocerebrosidase. Gaucher disease is classified into three types. In addition to enzyme replacement therapy, substrate reduction therapy, chemical chaperon therapy, and hematopoietic stem cell transplantation therapy are considered for the effective treatment of Gaucher disease.

  18. Menetrier's Disease

    Science.gov (United States)

    ... producing cells in the stomach, which decreases stomach acid. Ménétrier’s disease is also called Ménétrier disease or hypoproteinemic hypertrophic ... Alternate Versions PDF Version (102 KB) Additional Links Peptic Ulcer Disease Upper GI Endoscopy This content is provided as ...

  19. Glomerular Diseases

    Science.gov (United States)

    ... Disease Mineral & Bone Disorder Diabetes Inspidus Glomerular Diseases Goodpasture Syndrome Henoch-Schönlein Purpura IgA Nephropathy Kidney Disease in ... effective as cyclophosphamide and has milder side effects. Goodpasture's Syndrome involves an autoantibody that specifically targets the kidneys ...

  20. Morgellons Disease

    OpenAIRE

    Ohn, Jungyoon; Park, Seon Yong; Moon, Jungyoon; Choe, Yun Seon; Kim, Kyu Han

    2017-01-01

    Morgellons disease is a rare disease with unknown etiology. Herein, we report the first case of Morgellons disease in Korea. A 30-year-old woman presented with a 2-month history of pruritic erythematous patches and erosions on the arms, hands, and chin. She insisted that she had fiber-like materials under her skin, which she had observed through a magnifying device. We performed skin biopsy, and observed a fiber extruding from the dermal side of the specimen. Histopathological examination sho...

  1. Celiac Disease

    Directory of Open Access Journals (Sweden)

    Hero Brokalaki

    2008-07-01

    Full Text Available Celiac disease is a small intestine disease caused by the immunological response to gluten, a component of wheat, rye and barley. The worldwide prevalence of celiac disease ranges between 0.2% and 2.2 %. The clinical features of celiac disease includes diarrhea, steatorrhea, flatulence, abdominal pain and weight loss. The asymptomatic type of celiac disease is characterized by soft or normally shaped stool, weakness, lassitude and moderate weight loss. In children, celiac disease usually arises between the first and the third year of age, with diarrhea, flatulence and low weight. The malabsorption in small intestine causes many extaintestinal manifestations, such us anemia, bone abnormalities, hemorrhage and neuropathy. Celiac disease is diagnosed by histological examination of tissue samples taken by duodenum due gastroscopy and by the detection of certain antibodies in blood (anti-GL-IgG, anti-GL-IgA, ΕΜΑ-IgA και anti-tTg-IgA. The only therapeutic approach to celiac disease is a gluten-free diet and, if it is necessary, the administration of iron, folic acid, calcium and vitamins (K, B12. The prognosis of celiac disease is excellent, if there is an early diagnosis and the patient keeps for life a gluten free diet.

  2. Celiac disease

    Directory of Open Access Journals (Sweden)

    Holtmeier Wolfgang

    2006-03-01

    Full Text Available Abstract Celiac disease is a chronic intestinal disease caused by intolerance to gluten. It is characterized by immune-mediated enteropathy, associated with maldigestion and malabsorption of most nutrients and vitamins. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes. The main symptoms are: stomach pain, gas, and bloating, diarrhea, weight loss, anemia, edema, bone or joint pain. Prevalence for clinically overt celiac disease varies from 1:270 in Finland to 1:5000 in North America. Since celiac disease can be asymptomatic, most subjects are not diagnosed or they can present with atypical symptoms. Furthermore, severe inflammation of the small bowel can be present without any gastrointestinal symptoms. The diagnosis should be made early since celiac disease causes growth retardation in untreated children and atypical symptoms like infertility or neurological symptoms. Diagnosis requires endoscopy with jejunal biopsy. In addition, tissue-transglutaminase antibodies are important to confirm the diagnosis since there are other diseases which can mimic celiac disease. The exact cause of celiac disease is unknown but is thought to be primarily immune mediated (tissue-transglutaminase autoantigen; often the disease is inherited. Management consists in life long withdrawal of dietary gluten, which leads to significant clinical and histological improvement. However, complete normalization of histology can take years.

  3. Leigh's Disease

    Science.gov (United States)

    ... Related Dementias Bioengineering Epilepsy Health Disparities Neural Interfaces Parkinson's Disease Spinal Cord Injury Stem Cells Traumatic Brain Injury Trans-Agency Activities Interagency Research ...

  4. Celiac disease

    Directory of Open Access Journals (Sweden)

    Radlović Nedeljko

    2013-01-01

    Full Text Available Celiac disease is a multysystemic autoimmune disease induced by gluten in wheat, barley and rye. It is characterized by polygenic predisposition, high prevalence (1%, widely heterogeneous expression and frequent association with other autoimmune diseases, selective deficit of IgA and Down, Turner and Williams syndrome. The basis of the disease and the key finding in its diagnostics is symptomatic or asymptomatic inflammation of the small intestinal mucosa which resolves by gluten-free diet. Therefore, the basis of the treatment involves elimination diet, so that the disorder, if timely recognized and adequately treated, also characterizes excellent prognosis.

  5. Is "Parkinson's disease" one disease?

    OpenAIRE

    Calne, D B

    1989-01-01

    Consideration is given to how and why categories of ill health are divided into diseases. Aetiology is a fundamental criterion for the delineation of individual diseases. The same clinical and pathological picture may have many different causes; for example meningococcal meningitis and pneumococcal meningitis are distinct diseases that may display the same symptoms and signs. On the other hand, a single aetiology may lead to quite separate clinical and pathological phenomena; for example, neu...

  6. Endocrine Diseases

    Science.gov (United States)

    ... high or too low, you may have an endocrine disease or disorder. Endocrine diseases and disorders also occur if your body does not respond to hormones the way it is supposed to. Featured Topics Adrenal Insufficiency ... Topics Research Discoveries & News Children with Cushing ...

  7. Batten Disease

    Science.gov (United States)

    ... children with Batten disease who were treated with vitamins C and E and with diets low in vitamin A. However, these treatments did not prevent the ... Complications of AIDS Information Page Neurological Complications of Lyme Disease ... Page Neuromyelitis Optica Information Page Neuronal Migration ...

  8. Myocardial disease

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    970309 Myocardial injury of Keshan disease andapoptosis. ZHONG Xuekuan(钟学宽), et al. KeshanDis Instit, Harbin Med Univ, Harbin, 150086. Chin JEndemiol 1997, 16(2): 81-82. Objective: To discuss the relationship between my-ocardial injury Of Keshan disease and apoptosis. Meth-

  9. Wilson Disease

    Science.gov (United States)

    ... individuals with WD is liver disease, appearing in late childhood or early adolescence as acute hepatitis, liver failure, or progressive chronic ... individuals with WD is liver disease, appearing in late childhood or early adolescence as acute hepatitis, liver failure, or progressive chronic ...

  10. Kidney Disease

    Science.gov (United States)

    ... version of this page please turn Javascript on. Kidney Disease What is Kidney Disease? What the Kidneys Do Click for more information You have two ... damaged, wastes can build up in the body. Kidney Function and Aging Kidney function may be reduced ...

  11. Hartnup disease

    Directory of Open Access Journals (Sweden)

    Jerajani Hemangi

    1994-01-01

    Full Text Available A rare case of Hartnup disease is presented - the patient being an 11 year old school girl suffering from a typically pellagroid rash in the absence of any other signs of malnutrition. No accompanying neurological or psychiatric features are seen, but electro-encephalography revealed abnormal baseline activity. Investigations and management are detailed and the literature on Hartnup disease reviewed.

  12. Disease Lab

    OpenAIRE

    Powell, Jim; Lewis, Matt

    2016-01-01

    Students use transparencies and dry erase markers to simulate the spread of a zombie virus among a fixed population. Students are then challenged to create their own "disease" and develop an ODE model for the resulting data. From this exercise students gain greater understanding of population and SIR models, disease dynamics, parameter estimation and compartment modeling.

  13. Alzheimer's Disease

    Science.gov (United States)

    ... to note that Alzheimer's disease is not a normal part of aging. What Is Alzheimer's Disease? Video length: 2 min 29 sec Click to watch this video The course of Alzheimer’s disease—which symptoms appear and how quickly changes occur—varies from person to person. The time ...

  14. Facioscapulohumeral disease

    NARCIS (Netherlands)

    Padberg, George Waltherus Adrianus Maria

    1982-01-01

    The purpose of this study is to discuss several aspects of facioscapulohumeral disease, also called "autosomal dominant facioscapulohumeral muscular dystrophy" or "Landouzy-Dejerine type of muscular dystrophy" or "Landouzy-Dejerine' s disease" . We consider this disorder well defined and

  15. Whipple Disease

    Science.gov (United States)

    ... more common conditions with similar symptoms, including • inflammatory rheumatic disease— characterized by inflammation and loss of function in ... way to prevent Whipple disease. Eating, Diet, and Nutrition A person with Whipple disease and malabsorption may need • a diet high in ...

  16. Krabbe Disease

    Science.gov (United States)

    ... books/NBK1238/. Accessed Feb. 28, 2014. Krabbe disease. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/krabbe-disease. Accessed Feb, 28. 2014. Ropper AH, et al. Adams & Victor's Principles of Neurology. 9th ed. New York, N.Y.: ...

  17. Periodontal Disease and Systemic Health

    Science.gov (United States)

    ... Gum Disease and Other Diseases Gum Disease and Diabetes Gum Disease and Heart Disease Gum Disease and Other Systemic ... Gum Disease and Other Diseases Gum Disease and Diabetes Gum Disease and Heart Disease Gum Disease and Other Systemic ...

  18. Vascular Disease Foundation

    Science.gov (United States)

    ... Contact Us Vascular Disease What is Vascular Disease? Education and Awareness Vascular Diseases Abdominal Aortic Aneurysm Aortic Dissection Arteriovenous Malformation Atherosclerosis Buerger's Disease Carotid Artery Disease ...

  19. What Is Vascular Disease?

    Science.gov (United States)

    ... Contact Us Vascular Disease What is Vascular Disease? Education and Awareness Vascular Diseases Abdominal Aortic Aneurysm Aortic Dissection Arteriovenous Malformation Atherosclerosis Buerger's Disease Carotid Artery Disease ...

  20. Celiac Disease

    Directory of Open Access Journals (Sweden)

    Manoochehr Karjoo

    2014-08-01

    Full Text Available Celiac disease also known as gluten-sensitive enteropathy is characterized by intestinal mucosal damage and malabsorption from dietary intake of wheat, rye or barley. Symptoms may appear with introduction of cereal in the first 3 years of life. A second peak in symptoms occurs in adults during the third or forth decade and even as late as eight decade of life. The prevalence of this disease is approximately 1 in 250 adults. The disease is more prevalent in Ireland as high as 1 in 120 adults. The disorder occurs in Arab, Hispanics, Israeli Jews, Iranian and European but is rare in Chinese and African American. To have celiac disease the patient should have the celiac disease genetic markers as HLA DQ 2 and HLA DQ 8. Patient with celiac disease may have 95 per cent for DQ 2 and the rest is by DQ 8. Someone may have the genetic marker and never develops the disease. In general 50 percent with markers may develop celiac disease. To develop the disease the gene needs to become activated. This may happen with a viral or bacterial infection, a surgery, delivery, accident, or psychological stress. After activation of gene cause the tight junction to opens with the release of Zonulin This results in passage of gluten through the tight junction and formation of multiple antibodies and autoimmune disease. This also allows entrance of other proteins and development of multiple food allergies. As a result is shortening, flattening of intestinal villi resulting in food, vitamins and minerals malabsorption.

  1. Pompe's disease.

    Science.gov (United States)

    van der Ploeg, Ans T; Reuser, Arnold J J

    2008-10-11

    Pompe's disease, glycogen-storage disease type II, and acid maltase deficiency are alternative names for the same metabolic disorder. It is a pan-ethnic autosomal recessive trait characterised by acid alpha-glucosidase deficiency leading to lysosomal glycogen storage. Pompe's disease is also regarded as a muscular disorder, but the generalised storage of glycogen causes more than mobility and respiratory problems. The clinical spectrum is continuous and broad. First symptoms can present in infants, children, and adults. Cardiac hypertrophy is a key feature of classic infantile Pompe's disease. For a long time, there was no means to stop disease progression, but the approval of enzyme replacement therapy has substantially changed the prospects for patients. With this new development, the disease is now among the small but increasing number of lysosomal storage disorders, for which treatment has become a reality. This review is meant to raise general awareness, to present and discuss the latest insights in disease pathophysiology, and to draw attention to new developments about diagnosis and care. We also discuss the developments that led to the approval of enzyme replacement therapy with recombinant human alpha-glucosidase from Chinese hamster ovary cells (alglucosidase alfa) by the US Food and Drug Administration and European Medicines Agency in 2006, and review clinical practice.

  2. Refractory disease in autoimmune diseases

    NARCIS (Netherlands)

    Vasconcelos, Carlos; Kallenberg, Cees; Shoenfeld, Yehuda

    2011-01-01

    Refractory disease (RD) definition has different meanings but it is dynamic, according to knowledge and the availability of new drugs. It should be differentiated from severe disease and damage definitions and it must take into account duration of adequate therapy and compliance of the patient. It c

  3. Kummell disease.

    Science.gov (United States)

    Nickell, Larry T; Schucany, William G; Opatowsky, Michael J

    2013-07-01

    Kummell disease, or avascular necrosis of a vertebral body, presents as vertebral osteonecrosis typically affecting a thoracic vertebra with compression deformity, intravertebral vacuum cleft, and exaggerated kyphosis weeks to months after a minor traumatic injury. This rare disease is increasing in prevalence secondary to an aging population and the associated rise in osteoporosis. Treatment with vertebroplasty or surgical decompression and fusion is often required. We present a classic case of Kummell disease to illustrate the salient features of the condition, with associated imaging findings on computed tomography and magnetic resonance imaging.

  4. Crohn's disease.

    LENUS (Irish Health Repository)

    Shanahan, Fergus

    2012-02-03

    Crohn\\'s disease is a disorder mediated by T lymphocytes which arises in genetically susceptible individuals as a result of a breakdown in the regulatory constraints on mucosal immune responses to enteric bacteria. Regulation of immune reactivity to enteric antigens has improved understanding of the pathophysiological mechanisms of Crohn\\'s disease, and has expanded therapeutic options for patients with this disorder. Disease heterogeneity is probable, with various underlying defects associated with a similar pathophysiological outcome. Although most conventional drug treatments are directed at modification of host response, therapeutic manipulation of the enteric flora is becoming a realistic option.

  5. Fahr's Disease

    Directory of Open Access Journals (Sweden)

    Tezcan Caliskan

    2013-06-01

    Full Text Available Fahr's disease refers to sporadic or familial idiopathic basal ganglia, cerebral and cerebellar calcification. Patients may remain symptom-free but approximately two-thirds of the patients are symptomatic. Typical presentation starts in the 4th to 5th decades of life. Patients present with pyramidal, extrapyramidal, cerebellar, psychiatric and cognitive manifestations. Various diagnostic studies can be used to detect Fahr's disease and associated abnormalities. There is no specific treatment other than symptomatic support. In this review, clinical features and different types of presentations of Fahr's disease are discussed under the light of current literature. [J Contemp Med 2013; 3(2.000: 133-135

  6. [Fabry disease].

    Science.gov (United States)

    Boggio, Paula; Luna, Paula Carolina; Abad, María Eugenia; Larralde, Margarita

    2009-01-01

    Fabry disease is an uncommon, X-linked lysosomal storage disorder, caused by partial or complete deficiency of the enzyme a-galactosidase A. The defect leads to accumulation of uncleaved globotriaosylceramide on the vascular endothelium and visceral tissues, being the skin, heart, kidneys and central nervous system the most affected organs. We performed review of the literature related to the disease and emphasized that early recognition of angiokeratomas and hypohidrosis are key diagnostic signs of this serious disease. We also addressed the need of multidisciplinary assessment of these patients.

  7. Morgellons Disease.

    Science.gov (United States)

    Ohn, Jungyoon; Park, Seon Yong; Moon, Jungyoon; Choe, Yun Seon; Kim, Kyu Han

    2017-04-01

    Morgellons disease is a rare disease with unknown etiology. Herein, we report the first case of Morgellons disease in Korea. A 30-year-old woman presented with a 2-month history of pruritic erythematous patches and erosions on the arms, hands, and chin. She insisted that she had fiber-like materials under her skin, which she had observed through a magnifying device. We performed skin biopsy, and observed a fiber extruding from the dermal side of the specimen. Histopathological examination showed only mild lymphocytic infiltration, and failed to reveal evidence of any microorganism. The polymerase chain reaction for Borrelia burgdorferi was negative in her serum.

  8. Stargardt Disease

    Science.gov (United States)

    ... Resources Low Vision Specialists Retinal Physicians My Retina Tracker Registry Genetic Testing Clinical Trials Join the Fight ... of lipofuscin, a fatty byproduct of normal cell activity. In Stargardt disease, lipofuscin accumulates abnormally. The Foundation ...

  9. Pick disease

    Science.gov (United States)

    ... in behavior Failure to show emotional warmth, concern, empathy, sympathy Inappropriate mood Not caring about events or ... and steadily becomes worse. The person becomes totally disabled early in the course of the disease. Pick ...

  10. Vaginal Diseases

    Science.gov (United States)

    Vaginal problems are some of the most common reasons women go to the doctor. They may have ... that affect the vagina include sexually transmitted diseases, vaginal cancer, and vulvar cancer. Treatment of vaginal problems ...

  11. Legionnaires' Disease

    Science.gov (United States)

    Legionnaires' disease is a type of pneumonia caused by bacteria. You usually get it by breathing in mist from water that contains the bacteria. The mist may come from hot tubs, showers, or air-conditioning units for ...

  12. Infectious Diseases

    Science.gov (United States)

    ... people worldwide than any other single cause. Infectious diseases are caused by germs. Germs are tiny living things that are found everywhere - in air, soil and water. You can get infected by touching, eating, drinking ...

  13. Parkinson's Disease

    Science.gov (United States)

    ... sleep behavior disorder, which involves acting out your dreams. Medications may help your sleep problems. Bladder problems. ... will diagnose Parkinson's disease based on your medical history, a review of your signs and symptoms, and ...

  14. Gaucher Disease

    Science.gov (United States)

    ... Translational Research Research at NINDS Focus on Research Alzheimer's & Related Dementias Bioengineering Epilepsy Health Disparities Neural Interfaces Parkinson's Disease Spinal Cord Injury Stem Cells Traumatic Brain Injury Trans-Agency Activities Interagency Research ...

  15. Alexander Disease

    Science.gov (United States)

    ... Translational Research Research at NINDS Focus on Research Alzheimer's & Related Dementias Bioengineering Epilepsy Health Disparities Neural Interfaces Parkinson's Disease Spinal Cord Injury Stem Cells Traumatic Brain Injury Trans-Agency Activities Interagency Research ...

  16. Menkes Disease

    Science.gov (United States)

    ... Translational Research Research at NINDS Focus on Research Alzheimer's & Related Dementias Bioengineering Epilepsy Health Disparities Neural Interfaces Parkinson's Disease Spinal Cord Injury Stem Cells Traumatic Brain Injury Trans-Agency Activities Interagency Research ...

  17. Tickborne Diseases

    Science.gov (United States)

    ... of Award Clinical Terms of Award Restriction for China Clinical Terms Guidance Compliance Sample Letter Inclusion Codes ... Division of AIDS Division of Allergy, Immunology, and Transplantation Division of Microbiology and Infectious Diseases Division of ...

  18. Prion Diseases

    Science.gov (United States)

    ... of Award Clinical Terms of Award Restriction for China Clinical Terms Guidance Compliance Sample Letter Inclusion Codes ... Division of AIDS Division of Allergy, Immunology, and Transplantation Division of Microbiology and Infectious Diseases Division of ...

  19. [Prion diseases].

    Science.gov (United States)

    Zarranz, J J

    2006-10-01

    Prion diseases are one of the paradigms of modern neurological nosology founded on molecular grounds. Their incidence is low, however the public health challenges derived from their transmissibility, especially due to the appearance of a variant of Creutzfeldt-Jakob disease (vCJD) confers them a preferential place among health care authority concerns. The evolution of data from the European surveillance systems suggests a generalized underdiagnosis of prion diseases and casts doubts about their ability to detect a possible second wave of atypical vCJD, especially if their clinical-pathological characteristics change. Recent data also challenge the feasibility of a subclassification of prion diseases according to their genetic-molecular features

  20. Celiac Disease

    Science.gov (United States)

    ... gluten and to certain other proteins in the intestinal lining — a sign that the person could have celiac disease — then the doctor may order a biopsy of the small intestine to confirm the diagnosis. In the case of ...

  1. Autoinflammatory Diseases

    Science.gov (United States)

    ... disease. Colchicine – a medication also approved to treat gout (a form of arthritis) – has been used successfully as a treatment for FMF. Colchicine reduces inflammation throughout the body. ...

  2. Behcet's disease.

    Science.gov (United States)

    Nair, Jagdish R; Moots, Robert J

    2017-02-01

    Behçet's disease (BD) is a chronic relapsing and remitting vasculitis of unknown aetiology. It has the capacity to affect almost all organ systems because of its potential to involve both arteries and veins of all sizes, resulting in significant organ-threatening morbidity and mortality. Traditionally known as the 'silk road' disease, it has a worldwide occurrence. The aetiopathological mechanisms of disease development in BD remain poorly understood, but genome wide studies show human leukocyte antigen and non-human leukocyte antigen associations. Environmental influences and genetic factors may have a role in the aetiopathogenetic mechanisms that lead to development of the disease, indicating the autoimmune and auto-inflammatory nature of BD. The evidence base for treatment is limited but new knowledge is emerging and current treatment options range from symptomatic treatment, through to non-biological and biological immunosuppressive drugs, to cover the spectrum of clinical manifestations.

  3. Parkinson disease

    Science.gov (United States)

    ... control movement. Surgery to destroy brain tissue that causes Parkinson symptoms. Stem cell transplant and other procedures are ... in brain function and early death. Possible Complications Parkinson disease may cause problems such as: Difficulty performing daily activities Difficulty ...

  4. Heart Disease

    Science.gov (United States)

    ... Atherosclerosis is also the most common cause of cardiovascular disease. It can be caused by correctable problems, such as an unhealthy diet, lack of exercise, being overweight and smoking. Causes of heart arrhythmia ...

  5. Lyme Disease

    Science.gov (United States)

    ... can also spread to the nervous system, causing facial paralysis ( Bell_s_palsy ), or meningitis. The last stage of ... symptoms, joint pain or a swollen joint, or facial paralysis. Can I Prevent Lyme Disease? There's no surefire ...

  6. Endocrine Diseases

    Science.gov (United States)

    Your endocrine system includes eight major glands throughout your body. These glands make hormones. Hormones are chemical messengers. They ... levels. In the United States, the most common endocrine disease is diabetes. There are many others. They ...

  7. Hashimoto's Disease

    Science.gov (United States)

    ... use a combination of x rays and computer technology to create images. For a CT scan, a ... than men. Although the disease often occurs in adolescent or young women, it more commonly appears between ...

  8. Gum Disease

    Science.gov (United States)

    ... away from the teeth. This is known as periodontitis (pronounced: pair-ee-oh-don-TY-tus), a more advanced form of gum disease. With periodontitis, gums become weakened and form pockets around the ...

  9. Planning Diseases.

    Science.gov (United States)

    Gabel, Medard

    1984-01-01

    To solve societal problems, both local and global, a global approach is needed. Serious diseases that are crippling present-day problem solving and planning are discussed, and the characteristics of a healthy, effective planning approach are described. (RM)

  10. [Lyme disease].

    Science.gov (United States)

    Portillo, Aránzazu; Santibáñez, Sonia; Oteo, José A

    2014-02-01

    Lyme disease (LD) is a worldwide-distributed multisystemic process caused by Borrelia burgdorferi sensu lato (s.l.) and transmitted by hard ticks. In fact, it is the most common tick-borne infectious disease in the northern hemisphere. In Spain it is transmitted by Ixodes ricinus ticks and Borrelia garinii is the genoespecies of B. burgdorferi s.l. mostly involved in our area. LD is known as "the last great imitator" due to the broad clinical spectrum that may cause. Except in the case of erythema migrans (pathognomonic feature of the disease), the remaining clinical manifestations should be confirmed using microbiological tests. This review is intended to provide readers a current vision of the etiology, epidemiology, clinical manifestations, laboratory diagnosis and treatment of Lyme disease in our environment. Controversial aspects arising from the use of non-validated microbiological tests that are being used without scientific rigor are highlighted.

  11. Extrapyramidal disease

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008119 Therapeutic effect of neuropeptide PACAP27 on Parkinson′s disease in mice. WANG Gang(王刚), et al.Dept Neurol & Neurol Instit, Ruijin Hosp, Shanghai Jiaotong Univ, Med Sch, Shanghai 200025. Chin J Neurol 2007;40(12):837-841. Objective To investigate the effects of different doses of pituitary adenylate cyclase-activating polypeptide (PACAP) on the functional and morphological outcome in a mice model of Parkinson′s disease (PD) re

  12. Muscular disease

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930186 The diagnostic value of MRI on neuro-muscular disease.CHEN Qingtang(陈清棠),etal.Dept Neurol,1st Hosp,Beijing Med Univ,100034.Chin J Neurol & Psychiat 1992;25(5):267-269.The article concentrated on the study ofskeletal muscles of four extremities in 12 casesof different kinds of neuromuscular diseases and4 volunteers with MRI.The results revealed:MRI could clearly display individual muscle,muscle groups or abnormal muscles morphologi-

  13. [Ledderhose's disease].

    Science.gov (United States)

    Bardelli, M; D'Arienzo, M; Veneziani, C

    1991-01-01

    The authors describe the clinical appearance of Ledderhose disease and emphasize the association with Dupuytren disease. They report on a series of patients treated at the 2nd Orthopedic Unit of University of Florence and describe the operating technique used. They believe that the procedure of removal of nodules must always be performed in association with careful exeresis of normal tissue, employing total aponeurectomy only in revision surgery.

  14. Bowel disease

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008069 The application of Montreal classification in inflammatory bowel disease. YANG Chuanhua(杨川华), et al. Renji Hosp, Shanghai Instit, Shanghai Jiaotong Univ Med Coll, Shanghai 200001. Chin J Intern Med 2008;47(1):7-10. Objective To investigate the clinical features of Crohn′s disease (CD) and ulcerative colitis (UC) according to the Montreal classification. Methods The clinical data of 110 cases of CD or UC were reviewed. The age at

  15. Extrapyramidal disease

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008486 Neuropsychiatric problems in patients with Parkinson’s disease. ZHOU Mingzhu(周明珠), et al. Dept Neurol, Xinhua Hosp Shanghai Jiaotong Univ, Sch Med, Shanghai 200092.Natl Med J China 2008;88(21):1442-1445. Objective To survey the prevalence and distribution of neuropsychiatric problems in patients with Parkinson’s disease (PD), and to investigate their effects on life quality and the interactions among different neuropsychiatric problems.

  16. Huntington's disease

    OpenAIRE

    Bates, G P; Dorsey, R.; Gusella, J F; Hayden, M. R.; Kay, C; Leavitt, B. R.; Nance, M; Ross, C A; Scahill, R. I.; Wetzel, R.; Wild, E. J.; Tabrizi, S.J.

    2015-01-01

    Huntington’s disease is devastating to patients and their families — with autosomal dominant inheritance, onset typically in the prime of adult life, progressive course and combination of motor, cognitive and behavioural features. The disease is caused by an expanded CAG trinucleotide repeat (of variable length) in HTT, the gene which encodes the protein huntingtin. In mutation carriers, huntingtin is produced with abnormally long polyglutamine sequences that confers toxic gains of function a...

  17. [Kawasaki's disease].

    Science.gov (United States)

    Cortes, J; Martínez, B; Montini, C; Barraza, P; Reyes, A

    1989-08-01

    We described a case of Kawasaki's disease in a chilean girl, one year and 5 months old of age, who presented the oral characteristics, cutaneous and systemic manifestation of the condition, that is not very common for the dentist but that it is necessary to know due to the heart complications and the mortality associated with the disease, and it is necessary that the dentist recognize early this condition.

  18. O trabalho ante a desafiadora sociedade pós-industrial (os Fogos de Santelmo)

    OpenAIRE

    Kury, Francisco Otaviano Cichero

    2007-01-01

    O trabalho humano nem sempre foi considerado tarefa dignificante. Na Grécia e em Roma, na Antiguidade, as tarefas braçais eram desempenhadas por escravos, cabendo à classe abastada dedicar-se à filosofia ou a atividades ligadas às guerras. No período feudal, a escravidão foi substituída pela servidão; porém, isso não representou uma melhora de vida para os novos subjugados. Com o desmantelamento do feudalismo e do absolutismo, surgia, na sociedade agrária inglesa, o capitalismo que, mais tard...

  19. CORAGEM SOB FOGO: TESTANDO AS DOUTRINAS DE EPICTETO EM UM LABORATÓRIO COMPORTAMENTAL HUMANO

    Directory of Open Access Journals (Sweden)

    James Bond Stockdale

    2009-01-01

    Full Text Available Stockdale, falando sobre a sua aplicação das doutrinas de Epicteto em seus sete anos e meio como prisioneiro de guerra no Vietna, desenvolve uma série de estratégias para que as minorias possam prevalecer moralmente frente ao assédio moral de maiorias que procuram se impor por meio de coerção. Como um homem pode manter a dignidade num meio absolutamente hostil, onde a todo o momento procura-se coisificá-lo? Essa a questão a que Stockdale procura nos dar uma resposta atraves de um exercicio de etica aplicada.

  20. Groundwater Resources of Mosteiros Basin, Island of Fogo, Cape Verde, West Africa

    Science.gov (United States)

    Heilweil, Victor M.; Gingerich, Stephen B.; Plummer, L. Niel; Verstraeten, Ingrid M.

    2010-01-01

    Groundwater resources in Cape Verde provide water for agriculture, industry, and human consumption. These resources are limited and susceptible to contamination. Additional groundwater resources are needed for continued agricultural development, particularly during times of drought, but increased use and (or) climatic change may have adverse effects on the quantity and quality of freshwater available. In volcanic island aquifers such as those of Cape Verde, a lens of fresh groundwater typically ?floats? upon a layer of brackish water at the freshwater/saltwater boundary, and increased pumping may cause salt water intrusion or other contamination. A recent U.S. Geological Survey study assessed baseline groundwater conditions in watersheds on three islands of Cape Verde to provide the scientific basis for sustainably developing water resources and minimizing future groundwater depletion and contamination.

  1. DIREITOS HUMANOS SOB FOGO CRUZADO: INJUSTIÇA AMBIENTAL, RACISMO, SEXISMO E CLASSES SOCIAIS

    Directory of Open Access Journals (Sweden)

    Sávio Silva de Almeida

    2015-12-01

    Full Text Available O objeto estudado é a ameaça aos direitos humanos, que se sustenta em aspectos culturais (racismo e sexismo e de desigualdade (injustiça ambiental e desigualdade de classes. Partindo da preocupação acerca da ‘naturalização’ da discriminação, que constrói: o ‘outro’, a ‘natureza’, as ‘hierarquias’ sociais e os ‘colonialismos’, que tomam a forma de exclusões – racismo, sexismo –, desigualdades de classes e injustiça ambiental. Desta maneira, o presente artigo possui o objetivo de analisar como as doutrinas acerca da exclusão e da desigualdade favorecem as violações de direitos humanos. Para tanto, foi realizada extensa revisão bibliográfica acerca do objeto estudado.  Chegou-se a conclusão de que gênero, raça, injustiça ambiental e desigualdade de classes são construções sociais que se alinham para o enfraquecimento da relevância da construção socio-histórica dos direitos humanos. 

  2. INFLUÊNCIA DO FOGO NO BANCO DE SEMENTES DO SOLO EM FLORESTA ESTACIONAL SEMIDECIDUAL

    Directory of Open Access Journals (Sweden)

    Virgínia Londe de Camargos

    2013-01-01

    Full Text Available This study was carried out in a fragment called “Reserva da Biologia”, which belongs to the Universidade Federal de Viçosa, in Minas Gerais State, Brazil (20º35’-28º50’S e 42º45’-43º00’W, where 10 plots of 5 x 5 m plots, 1m away from each other, were set up. A controlled burning was performed on the plots, following the wind-driven fire technique, according to the slope orientation. The objective was to characterize the soil seed of the tree community before and after fire, in order to verify the effects of such discontinuance on both population density and floristic composition. In the centre of each plot, one 40 x 25 cm soil sampling was collected, from the leaf litter downward 5cm deep. One day after the soil sampling the plots underwent controlled burning. New soil samplings were done immediately after burning, following the previous methodology. It was counted 528 and 429 seedlings emerging from the soil seed bank before and after the fire, respectively. Such plants were of 23 species and 14 botanical families, from which Melastomataceae, Asteraceae and Urticaceae stood out. There was no meaningful reduction in the species richness or in the density of individuals of the populations between both samplings. The floristic similarity was 34 %. Miconia cinnamomifolia and Leandra purpurascens were the most frequent/abundant species. Pioneer species stood out making up 44 and 40 % of the species found in the area before and after fire, respectively.

  3. Qorpo Santo - Lanterna de Fogo : qompendio dramaturgiqo em paragrafos e imagens

    OpenAIRE

    João Andre Brito Garboggini

    2008-01-01

    Resumo: Esta tese apresenta uma jornada pela dramaturgia do autor José Joaquim de Campos Leão Qorpo Santo (1829-1883). Tem como objetivo transcriar sua escritura, inventando uma biografia poética do escritor gaúcho, por meio da elaboração de uma dramaturgia audiovisual. Trata-se de um mosaico de referências e citações composto por fragmentos dos textos do próprio Qorpo Santo, das lembranças de algumas encenações de suas peças teatrais, de artigos jornalísticos e de alguns escritos de outros a...

  4. Os efeitos dos fogos florestais nas comunidades de macroinvertebrados lóticos em Portugal

    OpenAIRE

    Machado, Ana Luísa Felgueiras de Brito

    2015-01-01

    The effects of wildfires in Mediterranean lotic communities are still poorly documented. Despite some progress in recent years, the published data refer mainly to studies conducted in North America, with little information on European rivers. Given the importance of regional geographic context, both on the effects of fire and on the resilience of the communities, the gap in the biogeographical knowledge represent a limitation to the implementation of appropriate management m...

  5. Agressão por arma branca e arma de fogo interligada ao consumo de drogas

    Directory of Open Access Journals (Sweden)

    Zélia Maria de Santos Sousa Araújo

    2004-01-01

    Full Text Available El objetivo de este estudio fue identificar y analizar el perfil de 80 clientes sometidos a intervención quirúrgica, víctimas de agresión por arma blanca o de fuego, que estaban sobre el efecto de sustancia psicoactiva. Los datos fueron obtenidos através de la entrevista y complementados con los registros de las historias clínicas. Se constató que la violencia fue mediada por la agresión de arma blanca o de fuego y la mayoría de los entrevistados eran usuarios de sustancias psicoactivas, jóvenes, solteros, sexo masculino, teniendo como escenario las calles, predominantemente en los finales de semana. Frente a los resultados, se sugiere la implementación de estrategias educativas, articulando las escuelas y la comunidad, con el objetivo de combatir la violencia, la drogadicción y el alcoholismo entre los niños y adolescentes.

  6. HIRAYAMA DISEASE

    Directory of Open Access Journals (Sweden)

    Shaik Sulaiman

    2016-05-01

    Full Text Available Hirayama’s disease, also known as Monomelic Amyotrophy (MMA, juvenile non-progressive amyotrophy, Sobue disease. It is rare and benign condition. It is a focal, lower motor neuron type of disorder, which occurs mainly in young males. Age of onset, it is first seen most commonly in people in their second and third decades. Geographically, it is seen most commonly in Asian countries like India and Japan. Cause of this disease is unknown in most cases. MRI of cervical spine in flexion is the investigation of choice, which will reveal the cardinal features of Hirayama disease. CASE REPORT 20 years old male came with the complaints of tremors of both hands more of right hand and weakness and wasting of right hand, which is slowly progressive for past 6 months. Lower limbs had no abnormality with normal deep tendon reflexes. On examination, there was wasting and weakness of hypothenar and interosseous muscles of right hand. MRI showed thinning of cord from C5 to C7 level. Proximal epidural fat and tiny flow voids with anterior migration of the posterior dural layer at C5-7 level on flexion MRI. Based on these features a diagnosis of focal amyotrophy was made. A cervical collar was prescribed and patient is under regular follow-up. CONCLUSION Hirayama disease is a rare self-limiting disease. Early diagnosis is necessary as the use of a simple cervical collar which will prevent neck flexion, has been shown to stop the progression.

  7. Learning about Crohn's Disease

    Science.gov (United States)

    ... genetic terms used on this page. Learning About Crohn's Disease What is Crohn's disease? What are the symptoms ... disease Additional Resources for Crohn's Disease What is Crohn's disease? Crohn's disease, an idiopathic (of unknown cause), chronic ...

  8. HIV and Rheumatic Disease

    Science.gov (United States)

    ... A Patient / Caregiver Diseases & Conditions HIV & Rheumatic Diseases HIV and Rheumatic Disease Fast Facts Rheumatic diseases related ... knows he or she has HIV. What are HIV-associated rheumatic diseases? Some diseases of the joints ...

  9. HIV and Rheumatic Disease

    Science.gov (United States)

    ... A Patient / Caregiver Diseases & Conditions HIV & Rheumatic Diseases HIV and Rheumatic Disease Fast Facts Rheumatic diseases related ... knows he or she has HIV. What are HIV-associated rheumatic diseases? Some diseases of the joints ...

  10. Niemann-Pick Disease

    Science.gov (United States)

    ... Disease] National Niemann-Pick Disease Foundation, Inc. National Tay-Sachs and Allied Diseases Association See all related ... Disease] National Niemann-Pick Disease Foundation, Inc. National Tay-Sachs and Allied Diseases Association See all related ...

  11. [Dupuytren disease].

    Science.gov (United States)

    Wagner, Pablo; Román, Javier A; Vergara, Jorge

    2012-09-01

    Dupuytren disease (DD) is a connective tissue disorder that consists in fibromatosis of the palmar and digital fascia (in form of nodules or flanges) that leads to the development of flexion contractures of the palm and fingers. The little and ring finger are particularly affected. The disease can limit hand function, reducing the quality of life. The disease can have a traumatic origin and is also associated with conditions such as diabetes mellitus, alcoholism, dyslipidemia, epilepsy and AIDS, among others. However, none of these conditions can fully explain the genesis of DD. A hereditary component is described in 40% of patients and is attributed to an autosomal dominant gene of variable penetrance, probably related to collagen synthesis. However there are also spontaneous and recessive inheritance cases. The diagnosis is clinical and based on physical examination. Treatment ranges from observation or use of injectable collagenase to the surgical option in cases with significant functional limitations.

  12. Celiac disease

    DEFF Research Database (Denmark)

    Hvas, Christian Lodberg; Jensen, Michael Dam; Reimer, Maria Christina;

    2015-01-01

    , which are found in wheat, rye, and barley. The disease prevalence is 0.5-1.0%, but CD remains under-diagnosed. The diagnosis relies on the demonstration of lymphocyte infiltration, crypt hyperplasia, and villous atrophy in duodenal biopsies. Serology, malabsorption, biochemical markers......This national clinical guideline approved by the Danish Society for Gastroenterology and Hepatology describes the diagnosis and treatment of celiac disease (CD) in adults. CD is a chronic immunemediated enteropathy of the small intestine triggered by the ingestion of gluten-containing proteins...... the small intestinal mucosa and absorption. Adherence to a GFD usually requires dietary advice from a clinical dietician. The monitoring of antibody levels and malabsorption markers is crucial during follow-up and allows for early treatment of disease complications. Important complications include...

  13. Myocardial disease

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930497 Ectopic expression and the significanceof HLA—class II antigens in the myocardium ofpatients with dilated cardiomyopathy.LI Yunyou(李运友),et al.lst Affili Hosp,Nanjing MedCoil,Nanjing,210029.Chin J Cardiol 1993;21(1):15—16.Expression of HLA—class II antigens(DQ,DP)in the myocardium of patients with differentheart diseases and normal controls was studiedwith indirect immunofluorescence(IIF).Thepositive rates in different groups were observedas follows:dilated cardiomyopathy(DCM,12/13,+++),rheumatic heart disease(2/4,++),congenital heart diseases(1/14,+),left a-trial myxoma(0/1)and normal controls(1/8,

  14. Celiac disease

    DEFF Research Database (Denmark)

    Hvas, Christian Lodberg; Jensen, Michael Dam; Reimer, Maria Christina

    2015-01-01

    This national clinical guideline approved by the Danish Society for Gastroenterology and Hepatology describes the diagnosis and treatment of celiac disease (CD) in adults. CD is a chronic immunemediated enteropathy of the small intestine triggered by the ingestion of gluten-containing proteins......, which are found in wheat, rye, and barley. The disease prevalence is 0.5-1.0%, but CD remains under-diagnosed. The diagnosis relies on the demonstration of lymphocyte infiltration, crypt hyperplasia, and villous atrophy in duodenal biopsies. Serology, malabsorption, biochemical markers...... the small intestinal mucosa and absorption. Adherence to a GFD usually requires dietary advice from a clinical dietician. The monitoring of antibody levels and malabsorption markers is crucial during follow-up and allows for early treatment of disease complications. Important complications include...

  15. Dent's disease

    Directory of Open Access Journals (Sweden)

    Thakker Rajesh V

    2010-10-01

    Full Text Available Abstract Dent's disease is a renal tubular disorder characterized by manifestations of proximal tubule dysfunction, including low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis, and progressive renal failure. These features are generally found in males only, and may be present in early childhood, whereas female carriers may show a milder phenotype. Prevalence is unknown; the disorder has been reported in around 250 families to date. Complications such as rickets or osteomalacia may occur. The disease is caused by mutations in either the CLCN5 (Dent disease 1 or OCRL1 (Dent disease 2 genes that are located on chromosome Xp11.22 and Xq25, respectively. CLCN5 encodes the electrogenic Cl-/H+ exchanger ClC-5, which belongs to the CLC family of Cl- channels/transporters. OCRL1 encodes a phosphatidylinositol bisphosphate (PIP2 5-phosphatase and mutations are also associated with Lowe Syndrome. The phenotype of Dent's disease is explained by the predominant expression of ClC-5 in the proximal tubule segments of the kidney. No genotype-phenotype correlation has been described thus far, and there is considerable intra-familial variability in disease severity. A few patients with Dent's disease do not harbour mutations in CLCN5 and OCRL1, pointing to the involvement of other genes. Diagnosis is based on the presence of all three of the following criteria: low-molecular-weight proteinuria, hypercalciuria and at least one of the following: nephrocalcinosis, kidney stones, hematuria, hypophosphatemia or renal insufficiency. Molecular genetic testing confirms the diagnosis. The differential diagnosis includes other causes of generalized dysfunction of the proximal tubules (renal Fanconi syndrome, hereditary, acquired, or caused by exogenous substances. Antenatal diagnosis and pre-implantation genetic testing is not advised. The care of patients with Dent's disease is supportive, focusing on the treatment of hypercalciuria and

  16. Celiac disease

    DEFF Research Database (Denmark)

    Hvas, Christian Lodberg; Jensen, Michael Dam; Reimer, Maria Christina;

    2015-01-01

    the small intestinal mucosa and absorption. Adherence to a GFD usually requires dietary advice from a clinical dietician. The monitoring of antibody levels and malabsorption markers is crucial during follow-up and allows for early treatment of disease complications. Important complications include......This national clinical guideline approved by the Danish Society for Gastroenterology and Hepatology describes the diagnosis and treatment of celiac disease (CD) in adults. CD is a chronic immunemediated enteropathy of the small intestine triggered by the ingestion of gluten-containing proteins...

  17. Hansen's disease: a vanishing disease?

    Directory of Open Access Journals (Sweden)

    Sinésio Talhari

    2012-12-01

    Full Text Available The introduction, implementation, successes and failures of multidrug therapy (MDT in all Hansen's disease endemic countries are discussed in this paper. The high efficacy of leprosy treatment with MDT and the global reduction of prevalence led the World Health Organization, in 1991, to establish the goal of elimination of Hansen's disease (less than 1 patient per 10,000 inhabitants to be accomplished by the year 2000. Brazil, Nepal and East Timor are among the few countries that didn't reach the elimination goal by the year 2000 or even 2005. The implications of these aspects are highlighted in this paper. Current data from endemic and previously endemic countries that carry a regular leprosy control programme show that the important fall in prevalence was not followed by the reduction of the incidence. This means that transmission of Mycobacterium leprae is still an issue. It is reasonable to conclude that we are still far from the most important goal of Hansen's disease control: the interruption of transmission and reduction of incidence. It is necessary to emphasize to health managers the need of keeping Hansen's disease control activities to better develop control programmes in the future. The recent international proposal to interrupt the transmission of leprosy by the year 2020 seems to unrealistic and it is discussed in this paper. The possibility of epidemiological impact related to the human immunodeficiency virus/Hansen's disease coinfection is also considered.

  18. Hansen's disease: a vanishing disease?

    Science.gov (United States)

    Talhari, Sinésio; Grossi, Maria Aparecida de Faria; Oliveira, Maria Leide W D R de; Gontijo, Bernardo; Talhari, Carolina; Penna, Gerson Oliveira

    2012-12-01

    The introduction, implementation, successes and failures of multidrug therapy (MDT) in all Hansen's disease endemic countries are discussed in this paper. The high efficacy of leprosy treatment with MDT and the global reduction of prevalence led the World Health Organization, in 1991, to establish the goal of elimination of Hansen's disease (less than 1 patient per 10,000 inhabitants) to be accomplished by the year 2000. Brazil, Nepal and East Timor are among the few countries that didn't reach the elimination goal by the year 2000 or even 2005. The implications of these aspects are highlighted in this paper. Current data from endemic and previously endemic countries that carry a regular leprosy control programme show that the important fall in prevalence was not followed by the reduction of the incidence. This means that transmission of Mycobacterium leprae is still an issue. It is reasonable to conclude that we are still far from the most important goal of Hansen's disease control: the interruption of transmission and reduction of incidence. It is necessary to emphasize to health managers the need of keeping Hansen's disease control activities to better develop control programmes in the future. The recent international proposal to interrupt the transmission of leprosy by the year 2020 seems to unrealistic and it is discussed in this paper. The possibility of epidemiological impact related to the human immunodeficiency virus/Hansen's disease coinfection is also considered.

  19. Myocardial disease

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920666 Immunocytochemical study ofCuZn superoxide dismutase in the myocardi-um of normal subjects and patients ofrheumatic heart disease.ZHENG Yi(郑毅),et al. Dept Intern Med, Navy General Hosp,PLA, Beijing. 100037. Natl Med J China 1992;72(4): 225-227. By using the methods of immunocytochemistry

  20. Parkinson's disease

    DEFF Research Database (Denmark)

    Astradsson, Arnar; Aziz, Tipu Z

    2015-01-01

    -derived therapy in people with Parkinson's disease? We searched: Medline, Embase, The Cochrane Library and other important databases up to September 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from...

  1. Wilson Disease

    Science.gov (United States)

    ... prevent organ damage. Changes in Eating, Diet, and Nutrition People with Wilson disease should reduce their dietary copper intake by avoiding foods that are high in copper, such as shellfish liver mushrooms nuts chocolate People should not eat these foods during the ...

  2. Mitochondrial Diseases

    Science.gov (United States)

    ... fats) that come from your food. When the mitochondria are defective, the cells do not have enough energy. The unused oxygen ... disease can vary. It depends on how many mitochondria are defective, and where ... organ, tissue, or cell type is affected. But often the problem affects ...

  3. Behcet's Disease

    Science.gov (United States)

    ... to stop taking the medicine suddenly, because the medicine alters the body’s production of the natural corticosteroid hormones. Long-term use of these medications can have side effects such as osteoporosis (a disease that leads to bone fragility), weight gain, delayed ...

  4. Huntington's disease

    DEFF Research Database (Denmark)

    Hjermind, Lena Elisabeth; Law, Ian; Jønch, Aia

    2011-01-01

    In this open-label pilot study, the authors evaluated the effect of memantine on the distribution of brain glucose metabolism in four Huntington's disease (HD) patients as determined by serial 18-fluoro-deoxyglucose [F(18)]FDG-PET scans over a period of 3-4 months (90-129 days, with one patient...

  5. Parkinson disease

    Science.gov (United States)

    In Parkinson disease, dopamine production becomes irregular and inadequate and nerve cells cannot properly transmit messages. This results in the loss of muscle function. By providing an even, adequate supply of medication that the body converts into dopamine, neurons are able to transmit ...

  6. Meningococcal disease

    Directory of Open Access Journals (Sweden)

    Alex Koyfman

    2011-12-01

    Full Text Available The first cases of meningococcal meningitis were described in Geneva in 1805 and in New England in 1806, the causative agent finally being identified by Anton Weichselbaum in 1887. The first meningococcal epidemics occurred in sub-Saharan Africa in the early 1900s and periodic outbreaks continue to occur worldwide today. Neisseria meningitidis colonizes the naso-oropharyngeal mucosa in approximately 10–20% of healthy individuals. When it invades the bloodstream, meningococcus has the potential to cause devastating disease. It can affect people of any age, but primarily infects children and adolescents. Meningococcemia classically follows an upper respiratory illness consisting of myalgias, fever, headache, and nausea. It can present as an indolent infection with rapid recovery or progress within a few hours into a fulminant illness affecting multiple organ systems. As such, meningococcemia is one of the important causes of sepsis. Prior to antibiotic therapy, the disease carried a 70% mortality rate. Despite advances in early diagnosis and treatment, 10–15% of affected patients die from the disease and another 10–20% are left with severe morbidities (neurologic disability, hearing loss, loss of a limb. Meningococcal disease remains a significant global health threat.

  7. Lung Diseases

    Science.gov (United States)

    When you breathe, your lungs take in oxygen from the air and deliver it to the bloodstream. The cells in your body need oxygen to ... you breathe nearly 25,000 times. People with lung disease have difficulty breathing. Millions of people in ...

  8. INFECTIOUS DISEASE

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    2.1 Viral disease2003263 Isolation, identification and sequence analyses of dengue virus type 2 strain GD19/2001. REN Rui-wen(任瑞文), et al. Milit Med Instit Guangzhou Milit District, Guangzhou 510507. Chin J Epidemiol 2003; 24 (4):288-290. Objective:To identify the virus isolated from patients

  9. INFECTIOUS DISEASE

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    3.1 Viral disease2004310 One-step simultaneous detection of G-genotype of human group a rotaviruses by multiplex RT-PCR. TANG Shaowen (唐少文) , et al. Dept Epidemiol, Tongji Med Coll Huozhong Univ Sci & Technol, Wuhan 430030. Chin J Lab Med 2004; 27 (4):234-236

  10. INFECTIOUS DISEASE

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    4. 1 Viral disease2004174 Study on the seropositive prevalence of humanimmunodeficiency virus in a village residents living in rural region of central China. CHENG Hua (程华), et al. Public Health Sch, Fudan Univ, Shanghai 200032. Chin J Epidemiol 2004;25(4):317 -321.

  11. Huntington's Disease

    Science.gov (United States)

    ... seizures. More than 30,000 Americans have HD. Huntington’s disease is caused by a mutation in the gene for a protein called huntingtin. The defect causes the cytosine, adenine, and guanine (CAG) building blocks of DNA to repeat many more ...

  12. Huntington disease

    Science.gov (United States)

    ... President of the Florida Society of Neurology (FSN). Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Huntington's Disease Read more Latest Health News Read more Health ...

  13. Prionic diseases

    Directory of Open Access Journals (Sweden)

    Abelardo Q-C Araujo

    2013-09-01

    Full Text Available Prion diseases are neurodegenerative illnesses due to the accumulation of small infectious pathogens containing protein but apparently lacking nucleic acid, which have long incubation periods and progress inexorably once clinical symptoms appear. Prions are uniquely resistant to a number of normal decontaminating procedures. The prionopathies [Kuru, Creutzfeldt-Jakob disease (CJD and its variants, Gerstmann-Sträussler-Scheinker (GSS syndrome and fatal familial insomnia (FFI] result from accumulation of abnormal isoforms of the prion protein in the brains of normal animals on both neuronal and non-neuronal cells. The accumulation of this protein or fragments of it in neurons leads to apoptosis and cell death. There is a strong link between mutations in the gene encoding the normal prion protein in humans (PRNP - located on the short arm of chromosome 20 – and forms of prion disease with a familial predisposition (familial CJD, GSS, FFI. Clinically a prionopathy should be suspected in any case of a fast progressing dementia with ataxia, myoclonus, or in individuals with pathological insomnia associated with dysautonomia. Magnetic resonance imaging, identification of the 14-3-3 protein in the cerebrospinal fluid, tonsil biopsy and genetic studies have been used for in vivo diagnosis circumventing the need of brain biopsy. Histopathology, however, remains the only conclusive method to reach a confident diagnosis. Unfortunately, despite numerous treatment efforts, prionopathies remain short-lasting and fatal diseases.

  14. INFECTIOUS DISEASE

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    3.1 Viral disease2003162 The clinical and epidemiological analysis on 46 patients with epidemic hemorrhagic fever in Huainan areas. WANG Kexia(王克霞). Sch Med, An-hui Univ Sci & Tehnol, Huainan 232001. Chin J En-demiol 2003;22(1):48-50.

  15. Extraphyramidal disease

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    2009250 Effects of bilateral deep brain stimulation of the subthalamic nucleus on depression in patients with parkinson’s disease. WANG Xuelian(王学廉),et al.Dept Neurosurg,Tangdu Hosp,4th Milit Med Univ,Xi’an,710038.Chin J Nerv Ment Dis,2009;35(2):88-92.

  16. Chagas Disease

    Science.gov (United States)

    ... contact with an infected triatomine bug also called “kissing bug,”“benchuca,” “vinchuca,”“chinche,”or “barbeiro” Who can ... get Chagas disease? ■ Usually from contact with a kissing bug ■ After the kissing bug bites, it poops. ...

  17. Neurodegenerative disorders: Parkinson's disease and Huntington's disease

    Science.gov (United States)

    Hague, S; Klaffke, S; Bandmann, O

    2005-01-01

    Parkinson's disease and Huntington's disease are both model diseases. Parkinson's disease is the most common of several akinetic-rigid syndromes and Huntington's disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biological studies have provided fascinating new insights into the pathogenesis of both disorders and there is now real hope for disease modifying treatment in the not too distant future for patients with Parkinson's disease or Huntington's disease. PMID:16024878

  18. Neurodegenerative disorders: Parkinson's disease and Huntington's disease.

    Science.gov (United States)

    Hague, S M; Klaffke, S; Bandmann, O

    2005-08-01

    Parkinson's disease and Huntington's disease are both model diseases. Parkinson's disease is the most common of several akinetic-rigid syndromes and Huntington's disease is only one of an ever growing number of trinucleotide repeat disorders. Molecular genetic studies and subsequent molecular biological studies have provided fascinating new insights into the pathogenesis of both disorders and there is now real hope for disease modifying treatment in the not too distant future for patients with Parkinson's disease or Huntington's disease.

  19. Infectious Disease

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    3.1 Viral disease2007149 Study on platelet β3 integrin expression levels and their relationships with disease severity in patients with hemorrhagic fever with renal syndrome.GAO Maicang(高麦仓), et al. Dept Infect Dis, 1st Affili Hosp, Sch Med, Xi′an Jiaotong Univ , Xi′an 710061. Chin J Infect Dis 2007;25(3):152-153. Objective To investigate the relationship between the expression level of platelet membrane glycoprotein 133(GP Ⅲa, CD61) and the severity of disease in patients with hemorrhagic fever with renal syndrome(HFRS). Methods One hundred and four patients with HFRS and 30 healthy individuals were recruited. The percentage of CD61 positive platelets and the mean fluorescence intensities (MFI) of platelet membrane glycoprotein β3 were determined by flow cytometry (FCM). The 104 patients studied were divided into three groups based on their expression levels of platelet membrane glycoprotein β3 at oliguric phase. Clinical data and laboratory parameters in different groups were compared and analyzed. Results The expression levels of CD61 in patients with HFRS were significantly higher than those in control group, although no significant difference in the percentage of CD61 positive platelets between patients with HFRS and controls was detected. The MFI of CD61 expression in patients with HFRS at fever phase, oliguric phase and polyuric phase was 19. 75±2.57, 17.46±1.48 and 15. 55±0.60, respectively, which was significantly higher than that in control group (3. 20±0.12). The expression level of CD61 in patients with HFRS at oliguric phase was negatively correlated with platelet count and serum albumin(r=-0.637 and -0. 695. respectively) and positively correlated with white blood cell count, blood urea nitrogen, serum creatinine and alanine aminotransferase(r= 0.945, 0. 904, 0.956 and 0. 891, respectively). When the patients were compared according to the expression levels of CD61, it was indicated that the higher the expression level of CD61, the

  20. Celiac disease

    Institute of Scientific and Technical Information of China (English)

    Luis Rodrigo

    2006-01-01

    Celiac disease (CD) is a common autoimmune disorder,induced by the intake of gluten proteins present in wheat, barley and rye. Contrary to common belief,this disorder is a protean systemic disease, rather than merely a pure digestive alteration. CD is closely associated with genes that code HLA-Ⅱ antigens, mainly of DQ2 and DQ8 classes. Previously, it was considered to be a rare childhood disorder, but is actually considered a frequent condition, present at any age, which may have multiple complications. Tissue transglutaminase-2(tTG), appears to be an important component of this disease, both, in its pathogenesis and diagnosis. Active CD is characterized by intestinal and/or extra-intestinal symptoms, villous atrophy and crypt hyperplasia, and strongly positive tTG auto-antibodies. The duodenal biopsy is considered to be the "gold standard" for diagnosis, but its practice has significant limitations in its interpretation, especially in adults. Occasionally, it results in a false-negative because of patchy mucosal changes and the presence of mucosal villous atrophy is often more severe in the proximal jejunum, usually not reached by endoscopic biopsies. CD is associated with increased rates of several diseases, such as iron deficiency anemia, osteoporosis, dermatitis herpetiformis,several neurologic and endocrine diseases, persistent chronic hypertransami-nasemia of unknown origin,various types of cancer and other autoimmune disorders.Treatment of CD dictates a strict, life-long gluten-free diet, which results in remission for most individuals,although its effect on some associated extraintestinal manifestations remains to be established.

  1. Bacterial disease

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930445 A report on investigation of an outbreakof legionnaires’disease in a hotel in Beijing.DENG Changying(邓长英),et al.Beijing ArmedForce General Hosp,Beijing,100027.Chin J Epi-demiol 1993;14(2):78—79.During the period from February to March,1992,an outbreak of upper respiratory infection(influenza—like syndrome)took place in a hotelin Beijing.An epidemiological investigation andbacteriological examination were carried out inthis hotel.The results showed that it was anoutbreak of Legionnaires’disease caused by Le-gionella pneumophila serogroup 10(Lpl0).Theincidence was 13.51%(5/37).This is the firstreport on Lp10 infection in China.

  2. Parkinson's disease

    DEFF Research Database (Denmark)

    Astradsson, Arnar; Aziz, Tipu Z

    2015-01-01

    INTRODUCTION: The mean age of onset of Parkinson's disease is about 65 years, with a median time of 9 years between diagnosis and death. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of fetal cell or stem cell......-derived therapy in people with Parkinson's disease? We searched: Medline, Embase, The Cochrane Library and other important databases up to September 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from...... relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found two studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS...

  3. Menkes disease.

    Science.gov (United States)

    Tümer, Zeynep; Møller, Lisbeth B

    2010-05-01

    Menkes disease (MD) is a lethal multisystemic disorder of copper metabolism. Progressive neurodegeneration and connective tissue disturbances, together with the peculiar 'kinky' hair are the main manifestations. MD is inherited as an X-linked recessive trait, and as expected the vast majority of patients are males. MD occurs due to mutations in the ATP7A gene and the vast majority of ATP7A mutations are intragenic mutations or partial gene deletions. ATP7A is an energy dependent transmembrane protein, which is involved in the delivery of copper to the secreted copper enzymes and in the export of surplus copper from cells. Severely affected MD patients die usually before the third year of life. A cure for the disease does not exist, but very early copper-histidine treatment may correct some of the neurological symptoms.

  4. Morgellons disease?

    Science.gov (United States)

    Accordino, Robert E; Engler, Danielle; Ginsburg, Iona H; Koo, John

    2008-01-01

    Morgellons disease, a pattern of dermatologic symptoms very similar, if not identical, to those of delusions of parasitosis, was first described many centuries ago, but has recently been given much attention on the internet and in the mass media. The present authors present a history of Morgellons disease, in addition to which they discuss the potential benefit of using this diagnostic term as a means of building trust and rapport with patients to maximize treatment benefit. The present authors also suggest "meeting the patient halfway" and creating a therapeutic alliance when providing dermatologic treatment by taking their cutaneous symptoms seriously enough to provide both topical ointments as well as antipsychotic medications, which can be therapeutic in these patients.

  5. Lyme Disease.

    Science.gov (United States)

    Hu, Linden T

    2016-05-03

    This issue provides a clinical overview of Lyme disease, focusing on prevention, diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers.

  6. Ledderhose Disease

    Science.gov (United States)

    Fausto de Souza, Dominique; Micaelo, Lilian; Cuzzi, Tullia

    2010-01-01

    Plantar fibromatosis, or Ledderhose disease, is a rare hyperproliferative disorder of the plantar aponeurosis. It may occur at any age with the greatest prevalence at middle age and beyond. This disorder is more common in men than woman and it is sometimes associated with other forms of fibromatosis. A 28-year-old Brazilian woman with a six-year history of painless bilateral plantar nodules is described in this article. PMID:20877526

  7. INFECTIOUS DISEASE

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    4.1 Viral disease2003021 Analysis on the epidemiologic features of Dengue fever in Guangdong province, 1990 - 2000. LUO Huiming(罗会明), et al. Dis Contr & Prev Center Guangdong Prov, Guangzhou 510300. Chin J Epi-demiol 2002;23(6):427-430.Objective: To determine the epidemiological characteristics and risk factors of Dengue fever in Guangdong province in 1990 - 2000, and to develop the strategy for

  8. Fungal disease

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930031 Experimental studies on lung lesionsof rabbits caused by streptomyces thermohy-groscopicus.LIU Fang(刘仿),et al.Dept Mi-crobiol,Hubei Med Coll,Xianning Branch,437100.Chin J Tuberc & Respir Dis 1992;15(4):207—208.Imitating the natural way of infection ofFarmer’s lung disease,we succeeded in inducingChina Medical Abstracts(Internal Medicine)

  9. Wilson's disease.

    Science.gov (United States)

    Loudianos, G; Gitlin, J D

    2000-01-01

    Wilson's disease is an autosomal recessive disorder of copper metabolism resulting from the absence or dysfunction of a copper transporting P-type ATPase encoded on chromosome 13. This ATPase is expressed in hepatocytes where it is localized to the trans-Golgi network and transports copper into the secretory pathway for incorporation into ceruloplasmin and excretion into the bile. Under physiologic circumstances, biliary excretion represents the sole mechanism for copper excretion, and thus affected individuals have progressive copper accumulation in the liver. When the capacity for hepatic storage is exceeded, cell death ensues with copper release into the plasma, hemolysis, and tissue deposition. Presentation in childhood may include chronic hepatitis, asymptomatic cirrhosis, or acute liver failure. In young adults, neuropsychiatric symptoms predominate and include dystonia, tremor, personality changes, and cognitive impairments secondary to copper accumulation in the central nervous system. The laboratory diagnosis of Wilson's disease is confirmed by decreased serum ceruloplasmin, increased urinary copper content, and elevated hepatic copper concentration. Molecular genetic analysis is complex as more than 100 unique mutations have been identified and most individuals are compound heterozygotes. Copper chelation with penicillamine is an effective therapy in most patients and hepatic transplantation is curative in individuals presenting with irreversible liver failure. Elucidation of the molecular genetic basis of Wilson's disease has permitted new insights into the mechanisms of cellular copper homeostasis.

  10. Polycystic Kidney Disease

    Science.gov (United States)

    ... Kidney Disease Polycystic Kidney Disease (PKD) Related Topics Section Navigation Kidney Disease Acquired Cystic Kidney Disease Amyloidosis & ... for a Child with Kidney Disease Ectopic Kidney Medullary Sponge Kidney Kidney Dysplasia Kidney Failure Choosing a ...

  11. Coronary heart disease

    Science.gov (United States)

    Heart disease, Coronary heart disease, Coronary artery disease; Arteriosclerotic heart disease; CHD; CAD ... slow down or stop. A risk factor for heart disease is something that increases your chance of getting ...

  12. Parkinson's Disease Dementia

    Science.gov (United States)

    ... Find your local chapter Join our online community Parkinson's Disease Dementia Parkinson's disease dementia is an impairment in ... disease. About Symptoms Diagnosis Causes & risks Treatments About Parkinson's disease dementia The brain changes caused by Parkinson's disease ...

  13. [Goodpasture disease].

    Science.gov (United States)

    Fomegné, G; Dratwa, M; Wens, R; Mesquita, M; Van der Straaten, M; Vanden Haute, K; Fosso, C

    2006-01-01

    We report one case of acute renal failure with oliguria, microscopic haematuria and normocytic anemia in a 86-year old Swedish woman. A full investigation led to the diagnosis of Goodpasture disease, an isolated form of Goodpasture syndrome. Goodpasture disease is and autoimmune disorder characterized by the development of autoantibodies to the NC1 domain of the alpha3 chain of type IV collagen, found mainly in glomerular basement membranes (GBM). When the disease affects both the lung and the kidney, it is called Goodpasture syndrome but the pulmonary or renal involvement can be isolated or separated in years. Its pathogenesis is not well known. It occurs essentially in Caucasian subjects, preferentially from Nordic and Anglo-Saxon countries (higher prevalence of HLA DR B1-15 and B1-4 group). Are also mentioned, the exposure to hydrocarbons, rustproof, insecticides and greasy solvents. The annual incidence of Goodpasture syndrome is rare and has been estimated in Europe to be about 0.5 to 1 case per million inhabitants. The isolated renal form represents about 1/3 of the cases. The clinical presentation is characterized by rapidly progressive renal failure with oliguria or anuria and in case of lung involvement, pulmonary hemorrhage responsible of hemoptysis, sometimes massive. Renal biopsy and immunofluorescence analysis play a key role in the diagnosis. The presence of both linear deposits of IgG along the glomerular basement membrane (GBM) and circulating anti-GBM antibodies is of paramount importance. The treatment, which depends on the degree of renal involvement, is based on the association of corticosteroids, cyclophosphamide and plasma exchanges.

  14. Celiac disease

    DEFF Research Database (Denmark)

    Hvas, Christian Lodberg; Jensen, Michael Dam; Reimer, Maria Christina

    2015-01-01

    This national clinical guideline approved by the Danish Society for Gastroenterology and Hepatology describes the diagnosis and treatment of celiac disease (CD) in adults. CD is a chronic immunemediated enteropathy of the small intestine triggered by the ingestion of gluten-containing proteins......, and identification of specific HLA haplotypes may contribute to CD diagnosis. Classical CD presents with diarrhoea and weight loss, but non-classical CD with vague or extraintestinal symptoms is common. The treatment for CD is a lifelong gluten-free diet (GFD), which, in the majority of patients, normalises...

  15. Menkes disease

    DEFF Research Database (Denmark)

    Tümer, Zeynep; Møller, Lisbeth B

    2010-01-01

    of patients are males. MD occurs due to mutations in the ATP7A gene and the vast majority of ATP7A mutations are intragenic mutations or partial gene deletions. ATP7A is an energy dependent transmembrane protein, which is involved in the delivery of copper to the secreted copper enzymes and in the export......Menkes disease (MD) is a lethal multisystemic disorder of copper metabolism. Progressive neurodegeneration and connective tissue disturbances, together with the peculiar 'kinky' hair are the main manifestations. MD is inherited as an X-linked recessive trait, and as expected the vast majority...

  16. Menkes disease

    OpenAIRE

    Tümer, Zeynep; Møller, Lisbeth B

    2009-01-01

    Menkes disease (MD) is a lethal multisystemic disorder of copper metabolism. Progressive neurodegeneration and connective tissue disturbances, together with the peculiar ‘kinky' hair are the main manifestations. MD is inherited as an X-linked recessive trait, and as expected the vast majority of patients are males. MD occurs due to mutations in the ATP7A gene and the vast majority of ATP7A mutations are intragenic mutations or partial gene deletions. ATP7A is an energy dependent transmembrane...

  17. Celiac disease.

    Science.gov (United States)

    Polanco, Isabel

    2008-08-01

    Celiac disease is an immunologically mediated enteropathy of the small intestine, characterized by lifelong intolerance to the gliadin and related prolamines from wheat and other cereals, that occurs in genetically predisposed individuals. Symptoms result from structural damage to the mucosa of the small intestine, which may cause malabsorption with positive autoantibodies in the sera. Normal mucosal architecture is restored after the use of a gluten-free diet and the normalization of the autoantibodies. Villous atrophy and high levels of autoantibodies reappear when gluten is reintroduced into the diet (gluten challenge).

  18. Infectious Disease

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    2.1 Viral disease 2006009 Correlation analysis of type A influenza virus genetic variation characteristic with survival selective pressure ZHOU xiao -ming(周晓明 ) ,et al. Sch Pub Health,Fudan Univ. Shanghai 200032. China J Infect Dis 2005;23(4) :221 -224 Objective:To study the relationship betweer. type A influenza virus genetic variation with survival selective pressure to find possible vaccine conserved antigen target. Methods:Seven strains of same HA (Hemagglutinin) serotype, regional and isolation time closely related type A influenza virus were selected with full HA gene coding sequence , Blast2 program was used to calculate the param-

  19. Women's Heart Disease: Heart Disease Risk Factors

    Science.gov (United States)

    ... this page please turn JavaScript on. Feature: Women's Heart Disease Heart Disease Risk Factors Past Issues / Winter 2014 Table of ... or habits may raise your risk for coronary heart disease (CHD). These conditions are known as risk factors. ...

  20. Crohn disease - children - discharge

    Science.gov (United States)

    Inflammatory bowel disease in children - Crohn disease; IBD in children - Crohn disease; Regional enteritis - children; Ileitis - children; Granulomatous ileocolitis - children; Colitis in children; CD - children

  1. Infectious diseases and arthropods

    National Research Council Canada - National Science Library

    Goddard, Jerome

    2000-01-01

    .... His book covers mosquito-, tick-, and flea-borne diseases, and a variety of other miscellaneous vector-borne diseases, including Chagas' disease, African sleeping sickness, onchocerciasis, scrub...

  2. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... of Parkinson's Disease OHSU - Parkinson's Disease: Managing Depression, Anxiety & Psychosis OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis OHSU - Therapeutic ...

  3. Hirayama disease

    Directory of Open Access Journals (Sweden)

    Atul T Tayade

    2010-01-01

    Full Text Available A 17-year-old male, who gave up his favorite sport cricket and started playing football, presented with one-year history of slowly progressive atrophic weakness of forearms and hands. Neurological examination showed weak and wasted arms, forearms and hand but no evidence of pyramidal tract, spinothalmic tract and posterior column lesions. Plain cervical spine radiographs showed no abnormal findings. Cervical magnetic resonance imaging (MRI showed asymmetric cord atrophy; images obtained with neck flexed showed the anterior shifting of the posterior wall of the lower cervical dural sac resulting in cord compression. These findings suggest Hirayama disease, a kind of cervical myelopathy related to the flexion movements of the neck.

  4. [Bone disease in Gaucher's disease].

    Science.gov (United States)

    Roca Espiau, Mercedes

    2011-09-01

    The exposition aims, is to review the pathophysiological mechanisms of bone marrow involvement and the patterns of marrow infiltration by Gaucher cells. We have reviewed the different methods of assessment of bone marrow infiltration and its temporal development. Qualitative methods include simple radiography, magnetic resonance imaging (MRI), computed tomography (CT) and radioisotope. The simple radiography is the basic element, but its sensitivity is limited and only allows for assessing changes and trabecular bone remodeling MRI allows us to appreciate the bone marrow infiltration, detection of complications and response to therapy. Radioisotopes can contribute to the differential diagnosis of osteomyelitis and bone crises. Among the quantitative methods are the QCSI (quantitative chemical shift imaging) and the dual-energy X-ray absorptiometry (DEXA), as well as new quantitative techniques of CT, MRI and ultrasound densitometry. The QCSI performed an assessment of fat content of bone marrow in the spine. DEXA quantifies bone density by measuring the attenuation coefficient. The semiquantitative methods have various "scores" to establish criteria for generalized bone disease endpoints of disease progression and response to therapy.

  5. Análise proteômica das estirpes selvagem, ntrC- e nifA- de Herbaspirillum seropedicae /

    OpenAIRE

    Chaves, Daniela Fojo Seixas

    2004-01-01

    Orientador : Fabio de Oliveira Pedrosa Dissertaçăo (mestrado) - Universidade Federal do Paraná, Setor de Ciencias Biológicas, Programa de Pós-Graduaçao em Bioquímica. Defesa: Curitiba, 2004 Inclui bibliografia

  6. Expressão heteróloga da forma selvagem e mutante da piruvato desidrogenase humana (hPDHE1): efeito de chaperones químicos

    OpenAIRE

    Florindo, Cristina Isabel Pereira

    2010-01-01

    Tese de mestrado em Bioquímica (Bioquímica Médica), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2010 O sistema piruvato desidrogenase humano (PDHc) e um complexo multienzimático, localizado na matriz mitocondrial, que apresenta uma função essencial no metabolismo da glucose ao promover a descarboxilação oxidativa do piruvato a acetil-CoA. De entre os seus constituintes, e de destacar o piruvato desidrogenase (E1; EC 1.2.4.1), uma proteína heterodimérica (α2β2) q...

  7. Undifferentiated Connective Tissue Disease

    Science.gov (United States)

    ... Home Conditions Undifferentiated Connective Tissue Disease (UCTD) Undifferentiated Connective Tissue Disease (UCTD) Make an Appointment Find a Doctor ... L. Goldstein, MD, MMSc (February 01, 2016) Undifferentiated connective tissue disease (UCTD) is a systemic autoimmune disease. This ...

  8. Associated Autoimmune Diseases

    Science.gov (United States)

    ... gland in the neck, thick and coarse hair. Addison’s Disease Arare disease involving the adrenal gland. The prevalence of celiac disease in people with addison’s disease is significant. Symptoms of Addison’s may include weight ...

  9. Genetics and Rheumatic Disease

    Science.gov (United States)

    ... Well with Rheumatic Disease Genetics and Rheumatic Disease Genetics and Rheumatic Disease Fast Facts Studying twins has ... 70%, and for non-identical pairs, even lower. Genetics and ankylosing spondylitis Each rheumatic disease has its ...

  10. Chronic Beryllium Disease

    Science.gov (United States)

    ... Science Education & Training Home Conditions Chronic Beryllium Disease Chronic Beryllium Disease Make an Appointment Find a Doctor ... MD, MSPH, FCCP (February 01, 2016) What is chronic beryllium disease (CBD)? Chronic beryllium disease (CBD) is ...

  11. Heart disease - risk factors

    Science.gov (United States)

    Heart disease - prevention; CVD - risk factors; Cardiovascular disease - risk factors; Coronary artery disease - risk factors; CAD - risk ... a certain health condition. Some risk factors for heart disease you cannot change, but some you can. ...

  12. Inflammation and Heart Disease

    Science.gov (United States)

    ... Disease Venous Thromboembolism Aortic Aneurysm More Inflammation and Heart Disease Updated:Oct 12,2016 Understand the risks of ... inflammation causes cardiovascular disease, inflammation is common for heart disease and stroke patients and is thought to be ...

  13. Lipid Storage Diseases

    Science.gov (United States)

    ... age 2, usually from lung disease. Children with Tay-Sachs and Sandhoff diseases often die at an ... age 2, usually from lung disease. Children with Tay-Sachs and Sandhoff diseases often die at an ...

  14. Heart disease and women

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007188.htm Heart disease and women To use the sharing features on ... please enable JavaScript. People often DO NOT consider heart disease a woman's disease. Yet cardiovascular disease is the ...

  15. Men and Heart Disease

    Science.gov (United States)

    ... Pressure Salt Cholesterol Million Hearts® WISEWOMAN Men and Heart Disease Fact Sheet Recommend on Facebook Tweet Share Compartir Source: Interactive Atlas of Heart Disease and Stroke Heart Disease Facts in Men Heart disease is the leading ...

  16. American Lyme Disease Foundation

    Science.gov (United States)

    ... Infectious Diseases, 35: 451-464, 2002) What is Lyme Disease? Lyme disease (LD) is an infection caused by ... mission with your own tax-deductible contribution. American Lyme Disease Foundation, Inc. PO Box 466 Lyme, CT 06371 ...

  17. Thyroid Disease (for Parents)

    Science.gov (United States)

    ... Teaching Kids to Be Smart About Social Media Thyroid Disease KidsHealth > For Parents > Thyroid Disease Print A ... many other parts of the body. What Is Thyroid Disease? Thyroid disease is when the thyroid gland ...

  18. Thyroid Disease and Teens

    Science.gov (United States)

    ... Surgery? Choosing the Right Sport for You Shyness Thyroid Disease KidsHealth > For Teens > Thyroid Disease Print A ... other parts of your body. continue What Is Thyroid Disease? Thyroid disease occurs when the thyroid gland ...

  19. Genetics and Rheumatic Disease

    Science.gov (United States)

    ... Well with Rheumatic Disease Genetics and Rheumatic Disease Genetics and Rheumatic Disease Fast Facts Studying twins has ... 70%, and for non-identical pairs, even lower. Genetics and ankylosing spondylitis Each rheumatic disease has its ...

  20. Pelvic Inflammatory Disease (PID)

    Science.gov (United States)

    ... Management Education & Events Advocacy For Patients About ACOG Pelvic Inflammatory Disease (PID) Home For Patients Search FAQs Pelvic Inflammatory ... Inflammatory Disease (PID) FAQ077, September 2015 PDF Format Pelvic Inflammatory Disease (PID) Gynecologic Problems What is pelvic inflammatory disease ( ...

  1. Thyroid Disease (for Parents)

    Science.gov (United States)

    ... Old Feeding Your 1- to 2-Year-Old Thyroid Disease KidsHealth > For Parents > Thyroid Disease A A ... many other parts of the body. What Is Thyroid Disease? Thyroid disease is when the thyroid gland ...

  2. Thyroid Disease and Teens

    Science.gov (United States)

    ... Loss Surgery? A Week of Healthy Breakfasts Shyness Thyroid Disease KidsHealth > For Teens > Thyroid Disease A A ... other parts of your body. continue What Is Thyroid Disease? Thyroid disease occurs when the thyroid gland ...

  3. Sickle Cell Disease

    Science.gov (United States)

    ... sickle cell disease?Sickle cell disease, also called sickle cell anemia, is a hereditary condition (which means it runs ... disease, hemoglobin SS disease, hemoglobin synthesis, hemoglobinopathies, ... cell anemia, sickle cell crisis, vaso-occlusive crisis Family Health, ...

  4. Gaucher Disease in Pregnancy

    Science.gov (United States)

    ... from your health care provider. What is Gaucher disease? Gaucher disease is a genetic disorder. People with Gaucher ... severe and depend on the type of Gaucher disease. Gaucher disease occurs in approximately 1 in 60,000 ...

  5. Aortic Valve Disease

    Science.gov (United States)

    ... Tricuspid Valve Disease Cardiac Rhythm Disturbances Thoracic Aortic Aneurysm Pediatric and Congenital Heart Disease Heart abnormalities that are ... Transplantation End-stage Lung Disease Adult Lung Transplantation Pediatric Lung ... Aortic Aneurysm Aortic Valve Disease Overview The human heart has ...

  6. What Is Vascular Disease?

    Science.gov (United States)

    ... Donors Corporate Sponsors Donor Privacy Policy What Is Vascular Disease? What Is Vascular Disease? Vascular disease is any abnormal condition of ... steps to prevent vascular disease here. Understanding the Vascular System Your vascular system – the highways of the ...

  7. Parkinson's disease.

    Science.gov (United States)

    Benninger, David H

    2013-01-01

    In advanced Parkinson's disease (PD), the emergence of symptoms refractory to conventional therapy poses therapeutic challenges. The success of deep brain stimulation (DBS) and advances in the understanding of the pathophysiology of PD have raised interest in noninvasive brain stimulation as an alternative therapeutic tool. The rationale for its use draws from the concept that reversing abnormalities in brain activity and physiology thought to cause the clinical deficits may restore normal functioning. Currently the best evidence in support of this concept comes from DBS, which improves motor deficits, and modulates brain activity and motor cortex physiology, although whether a causal interaction exists remains largely undetermined. Most trials of noninvasive brain stimulation in PD have applied repetitive transcranial magnetic stimulation (rTMS), targeting the motor cortex. Current studies suggest a possible therapeutic potential for rTMS and transcranial direct current stimulation (tDCS), but clinical effects so far have been small and negligible with regard to functional independence and quality of life. Approaches to potentiate the efficacy of rTMS include increasing stimulation intensity and novel stimulation parameters that derive their rationale from studies on brain physiology. These novel parameters are intended to simulate normal firing patterns or to act on the hypothesized role of oscillatory activity in the motor cortex and basal ganglia with regard to motor control and its contribution to the pathogenesis of motor disorders. Noninvasive brain stimulation studies will enhance our understanding of PD pathophysiology and might provide further evidence for potential therapeutic applications.

  8. [Castleman disease].

    Science.gov (United States)

    Belletti, Gerardo A; Savio, Verónica; Minoldo, Daniel; Caminos, Susana; Yorio, Marcelo A

    2004-01-01

    A 66 years female, who was since last year under astenia, arthralgias, pimply lesions in spread plates and tests showing eritrosedimentation over 100 mm, anemi, leucocitosis with neutrofilia, policlonal hypergammaglobulinemia, slight proteinuria and IgE on 900. This patient was sporadically treated with corticoids. When made the medical consult had lost 34lb., was under anorexy, as well as dyspepsia. Hemoglobyn 6.9 gr/dl, leucocytes 20000/mm3, neutrofils at 90%, proteinogram the same as former, with hypoalbuminemia. She was taking prednisona, 16 mg/day. When examined showed depress of conscience, astenia, and dermic lesions already quoted. 4 cm nonpainful right axillary adenopaty adhered to deep planes. Medulogram with increased iron, hyperegenerative. Ganglionar biopsia: linfoid hyperplasic process linked to inmune response. Toracoabdominal tomography with adenomegalia in torax and retroperitoneo. Skin biopsia: neutrofilic vasculitis. The patient suspends the 16 mg of prednisona and fever as well as generalized adenopatias come up. After laying aside other ethiologies, and understanding as Castleman Multicentric disease, it is started to supply prednisona 1 mg/kg of weight with a clinical and biochemical fast and outstanding response. After 7 months it was progressively suspended the esteroids and 60 days later, the process fall back; for that, corticoids are restarted, with a good evolution. The illness of Castleman although it is not very frequent, it should be considered as differential diagnosis in those clinical cases that are accompanied with important general commitment, linphadenopaties and respons to steroid therapy.

  9. Blood and Lymph Diseases

    Science.gov (United States)

    ... and Disease [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 1998-. Blood and Lymph Diseases. PDF version of this page ( ... On Blood and Lymph Diseases - Genes and Disease Blood and Lymph Diseases - Genes and Disease Your browsing ... Biotechnology Information , U.S. National Library of Medicine 8600 Rockville ...

  10. Muscle disease.

    Science.gov (United States)

    Tsao, Chang-Yong

    2014-02-01

    On the basis of strong research evidence, Duchenne muscular dystrophy (DMD), the most common severe childhood form of muscular dystrophy, is an X-linked recessive disorder caused by out-of-frame mutations of the dystrophin gene. Thus, it is classified asa dystrophinopathy. The disease onset is before age 5 years. Patients with DMD present with progressive symmetrical limb-girdle muscle weakness and become wheelchair dependent after age 12 years. (2)(3). On the basis of some research evidence,cardiomyopathy and congestive heart failure are usually seen in the late teens in patients with DMD. Progressive scoliosis and respiratory in sufficiency often develop once wheelchair dependency occurs. Respiratory failure and cardiomyopathy are common causes of death, and few survive beyond the third decade of life. (2)(3)(4)(5)(6)(7). On the basis of some research evidence, prednisone at 0.75 mg/kg daily (maximum dose, 40 mg/d) or deflazacort at 0.9 mg/kg daily (maximum dose, 39 mg/d), a derivative of prednisolone (not available in the United States), as a single morning dose is recommended for DMD patients older than 5 years, which may prolong independent walking from a few months to 2 years. (2)(3)(16)(17). Based on some research evidence, treatment with angiotensin-converting enzyme inhibitors, b-blockers, and diuretics has been reported to be beneficial in DMD patients with cardiac abnormalities. (2)(3)(5)(18). Based on expert opinion, children with muscle weakness and increased serum creatine kinase levels may be associated with either genetic or acquired muscle disorders (Tables 1 and 3). (14)(15)

  11. Alzheimer disease: An interactome of many diseases

    Directory of Open Access Journals (Sweden)

    Balaji S Rao

    2014-01-01

    Full Text Available Alzheimer Disease (AD is an outcome as well as source of many diseases. Alzheimer is linked with many other diseases like Diabetes type 2, cholesterolemia, hypertension and many more. But how each of these diseases affecting other is still unknown to scientific community. Signaling Pathways of one disease is interlinked with other disease. But to what extent healthy brain is affected when any signaling in human body is disturbed is the question that matters. There is a need of Pathway analysis, Protein-Protein interaction (PPI and the conserved interactome study in AD and linked diseases. It will be helpful in finding the potent drug or vaccine target in conscious manner. In the present research the Protein-Protein interaction of all the proteins involved in Alzheimer Disease is analyzed using ViSANT and osprey tools and pathway analysis further reveals the significant genes/proteins linking AD with other diseases.

  12. Association between periodontal diseases and systemic diseases.

    Science.gov (United States)

    Weidlich, Patrícia; Cimões, Renata; Pannuti, Claudio Mendes; Oppermann, Rui Vicente

    2008-01-01

    Current evidence suggests that periodontal disease may be associated with systemic diseases. This paper reviewed the published data about the relationship between periodontal disease and cardiovascular diseases, adverse pregnancy outcomes, diabetes and respiratory diseases, focusing on studies conducted in the Brazilian population. Only a few studies were found in the literature focusing on Brazilians (3 concerning cardiovascular disease, 7 about pregnancy outcomes, 9 about diabetes and one regarding pneumonia). Although the majority of them observed an association between periodontitis and systemic conditions, a causal relationship still needs to be demonstrated. Further studies, particularly interventional well-designed investigations, with larger sample sizes, need to be conducted in Brazilian populations.

  13. Inflammatory bowel disease and airway diseases

    Science.gov (United States)

    Vutcovici, Maria; Brassard, Paul; Bitton, Alain

    2016-01-01

    Airway diseases are the most commonly described lung manifestations of inflammatory bowel disease (IBD). However, the similarities in disease pathogenesis and the sharing of important environmental risk factors and genetic susceptibility suggest that there is a complex interplay between IBD and airway diseases. Recent evidence of IBD occurrence among patients with airway diseases and the higher than estimated prevalence of subclinical airway injuries among IBD patients support the hypothesis of a two-way association. Future research efforts should be directed toward further exploration of this association, as airway diseases are highly prevalent conditions with a substantial public health impact. PMID:27678355

  14. Association between periodontal diseases and systemic diseases

    Directory of Open Access Journals (Sweden)

    Patrícia Weidlich

    2008-08-01

    Full Text Available Current evidence suggests that periodontal disease may be associated with systemic diseases. This paper reviewed the published data about the relationship between periodontal disease and cardiovascular diseases, adverse pregnancy outcomes, diabetes and respiratory diseases, focusing on studies conducted in the Brazilian population. Only a few studies were found in the literature focusing on Brazilians (3 concerning cardiovascular disease, 7 about pregnancy outcomes, 9 about diabetes and one regarding pneumonia. Although the majority of them observed an association between periodontitis and systemic conditions, a causal relationship still needs to be demonstrated. Further studies, particularly interventional well-designed investigations, with larger sample sizes, need to be conducted in Brazilian populations.

  15. Skin Diseases: Skin Health and Skin Diseases

    Science.gov (United States)

    Skip Navigation Bar Home Current Issue Past Issues Skin Diseases Skin Health and Skin Diseases Past Issues / Fall 2008 Table of Contents ... acne to wrinkles Did you know that your skin is the largest organ of your body? It ...

  16. Acquired Cystic Kidney Disease

    Science.gov (United States)

    ... Kidney Disease (CKD) What Is Chronic Kidney Disease? Causes of CKD Tests & Diagnosis Managing CKD Eating Right Preventing CKD ... as polycystic kidney disease (PKD), another disease that causes the kidneys to ... chronic kidney disease (CKD)—a condition that develops over many years ...

  17. Lyme Disease (For Parents)

    Science.gov (United States)

    ... Teaching Kids to Be Smart About Social Media Lyme Disease KidsHealth > For Parents > Lyme Disease Print A A ... en español La enfermedad de Lyme What Is Lyme Disease? Lyme disease is the leading tick-borne disease ...

  18. Virus diseases of fish

    Science.gov (United States)

    Watson, Stanley W.

    1954-01-01

    Viruses are probably the cause of a wide spectrum of fish diseases. Although relatively few virus diseases of fish are known today, some of the diseases of unknown etiology, as well as some diseases presently accepted as due to bacteria, protozoa, fungi or nutritional deficiencies, possibly will be recognized eventually as virus diseases.

  19. KEGG DISEASE / Acute encephalitis [KEGG DISEASE

    Lifescience Database Archive (English)

    Full Text Available DISEASE: H01417 Entry H01417Disease Name Acute encephalitis Description Acute encep...ns Infections caused by dsDNA viruses H01417Acute encephalitis Human diseases in ICD-10 classification [BR:b...of the central nervous system G04Encephalitis, myelitis and encephalomyelitis H01417Acute encephalitis Patho...elines for management. Journal Eur J Neurol 12:331-43 (2005) KEGG DISEASE / Acute encephalitis ...

  20. Coronary Artery Disease - Coronary Heart Disease

    Science.gov (United States)

    ... result of coronary artery disease, or CAD, said Edward A. Fisher, M.D., Ph.D., M.P. ... Problems and Disease • High Blood Pressure (HBP) • Metabolic Syndrome • Pericarditis • Peripheral Artery Disease (PAD) • Stroke • Vascular Health • ...

  1. KEGG DISEASE / Acute alcohol sensitivity [KEGG DISEASE

    Lifescience Database Archive (English)

    Full Text Available DISEASE: H01071 Entry H01071Disease Name Acute alcohol sensitivity Description Alde...bolism Congenital disorders of carbohydrate metabolism H01071Acute alcohol sensit...eases. Journal Cardiovasc Res 88:51-7 (2010) KEGG DISEASE / Acute alcohol sensitivity ...

  2. Lysosomal storage disease 2 - Pompe's disease

    NARCIS (Netherlands)

    van der Ploeg, Ans T.; Reuser, Arnold J. J.

    2008-01-01

    Pompe's disease, glycogen-storage disease type II, and acid maltase deficiency are alternative names for the same metabolic disorder. It is a pan-ethnic autosomal recessive trait characterised by acid alpha-glucosidase deficiency leading to lysosomal glycogen storage. Pompe's disease is also

  3. Anemia of chronic disease

    Science.gov (United States)

    ... disease Long-term infections, such as bacterial endocarditis, osteomyelitis (bone infection), HIV/AIDS , hepatitis B or hepatitis ... disease Crohn disease Erythropoietin test Juvenile idiopathic arthritis Osteomyelitis Rheumatic fever Ulcerative colitis Review Date 2/1/ ...

  4. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Parkinson's Disease Cognition: A Mind Guide to Parkinson’s Disease Nutrition Matters Speech and Swallowing Psychosis: A Mind Guide to Parkinson's Disease Guide to Deep Brain Stimulation You Can Make ...

  5. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... and Social Network? How Does Parkinson's Disease Affect Memory? How Does Parkinson's Disease Affect the Urinary System? ... Parkinson's Disease Patients with a Depression Diagnosis? What Type of Exercise or Exercise Programs Are Recommended? What ...

  6. Newcastle Disease Virus (PDQ)

    Science.gov (United States)

    ... Professionals Questions to Ask about Your Treatment Research Newcastle Disease Virus (PDQ®)–Patient Version Overview Go to ... cancer (see Question 8 ). Questions and Answers About Newcastle Disease Virus What is Newcastle disease virus? Newcastle ...

  7. Learn About Neuromuscular Disease

    Science.gov (United States)

    ... Inherited and Endocrine Myopathies Metabolic Diseases of Muscle Mitochondrial Myopathies (MM) Myotonic Muscular Dystrophy (MMD) Spinal-Bulbar Muscular ... Deficient Congenital Muscular Dystrophy Metabolic Diseases of Muscle Mitochondrial Myopathy Miyoshi Distal Myopathy Motor Neurone Disease Muscle-Eye- ...

  8. Autoimmune liver disease panel

    Science.gov (United States)

    Liver disease test panel - autoimmune ... Autoimmune disorders are a possible cause of liver disease. The most common of these diseases are autoimmune hepatitis and primary biliary cholangitis (formerly called primary biliary cirrhosis). This group of tests ...

  9. Liver Disease and IBD

    Science.gov (United States)

    ... Home > Resources > Liver Disease and IBD Go Back Liver Disease and IBD Email Print + Share Several complications ... be necessary to make the definitive diagnosis. FATTY LIVER DISEASE (HEPATCI STEATOSIS) This is the most common ...

  10. Leprosy (Hansen's Disease)

    Science.gov (United States)

    ... with facebook share with twitter share with linkedin Leprosy (Hansen's Disease) Leprosy (Hansen's Disease) is a chronic ... as Mycobacterium leprae . Why Is the Study of Leprosy (Hansen's Disease) a Priority for NIAID? At the ...

  11. Reflux and Lung Disease

    Science.gov (United States)

    ... Healthy Eating Reflux and Lung Disease Reflux and Lung Disease Make an Appointment Ask a Question Find a Doctor Many people with chronic lung disease also suffer from gastroesophageal reflux (GERD). In this ...

  12. Tay-Sachs Disease

    Science.gov (United States)

    Tay-Sachs disease is a rare, inherited disease. It is a type of lipid metabolism disorder. It ... cells, causing mental and physical problems. . Infants with Tay-Sachs disease appear to develop normally for the ...

  13. Diabetic Heart Disease

    Science.gov (United States)

    ... be coronary heart disease (CHD), heart failure, and diabetic cardiomyopathy. Diabetes by itself puts you at risk for heart disease. Other risk factors include Family history of heart disease Carrying extra ...

  14. Heart Disease (For Kids)

    Science.gov (United States)

    ... CPR: A Real Lifesaver Kids Talk About: Coaches Heart Disease KidsHealth > For Kids > Heart Disease Print A A ... chest pain, heart attacks, and strokes . What Is Heart Disease? The heart is the center of the cardiovascular ...

  15. Heart Diseases and Disorders

    Science.gov (United States)

    ... Resources Heart Diseases & Disorders Back to Patient Resources Heart Diseases & Disorders Millions of people experience irregular heartbeats, called ... harmless and happen in healthy people free of heart disease. However, some abnormal heart rhythms can be serious ...

  16. Parkinson disease - discharge

    Science.gov (United States)

    Your doctor has told you that you have Parkinson disease . This disease affects the brain and leads to ... have you take different medicines to treat your Parkinson disease and many of the problems that may come ...

  17. What Is Parkinson's Disease?

    Science.gov (United States)

    ... resources & more. Order Free Materials Today What is Parkinson’s Disease? Parkinson's disease (PD) is a chronic and progressive movement disorder, ... million people in the US are living with Parkinson's disease. The cause is unknown, and although there is ...

  18. Cardiovascular Disease and Diabetes

    Science.gov (United States)

    ... Disease Venous Thromboembolism Aortic Aneurysm More Cardiovascular Disease & Diabetes Updated:Apr 14,2017 The following statistics speak ... disease. This content was last reviewed August 2015. Diabetes • Home • About Diabetes • Why Diabetes Matters Introduction Cardiovascular ...

  19. Heart Disease Risk Factors

    Science.gov (United States)

    ... Hearts® WISEWOMAN Program Other Chronic Disease Topics Diabetes Nutrition Obesity Physical Activity Stroke Heart Disease Risk Factors Recommend ... Hearts® WISEWOMAN Program Other Chronic Disease Topics Diabetes Nutrition Obesity Physical Activity Stroke File Formats Help: How do ...

  20. Lyme disease (image)

    Science.gov (United States)

    Lyme disease is an acute inflammatory disease characterized by skin changes, joint inflammation and symptoms similar to the ... that is caused by the bacterium Borrelia burgdorferi . Lyme disease is transmitted by the bite of a deer ...

  1. Kidney Disease (Nephropathy)

    Science.gov (United States)

    ... Text Size: A A A Listen En Español Kidney Disease (Nephropathy) Kidneys are remarkable organs. Inside them ... resulting in kidney disease. How Does Diabetes Cause Kidney Disease? When our bodies digest the protein we ...

  2. Learning about Dercum Disease

    Science.gov (United States)

    ... About Dercum Disease Specific Genetic Disorders Specific Genetic Disorders Learning About Prostate Cancer See Also: Talking Glossary of ... Definitions for genetic terms used on this page. Learning About Dercum Disease What is Dercum disease? What are the symptoms ...

  3. Learning about Parkinson's Disease

    Science.gov (United States)

    ... About Parkinson's Disease Specific Genetic Disorders Specific Genetic Disorders Learning About Prostate Cancer See Also: Talking Glossary of ... diseases Journal of Biological Chemistry , June 9, 2011 Learning About Parkinson's Disease What do we know about heredity and Parkinson's ...

  4. Pediatric Celiac Disease

    Science.gov (United States)

    ... of Pediatric Gastroenterology and Nutrition Nurses Print Share Celiac Disease Many kids have sensitivities to certain foods, and ... protein found in wheat, rye, and barley. Pediatric Celiac Disease If your child has celiac disease, consuming gluten ...

  5. Eye Disease Simulations

    Science.gov (United States)

    ... USAJobs Home > Eye Health Information > Eye Disease Simulations Eye Disease Simulations Age-Related Macular Degeneration Cataract Diabetic ... information page Back to top Diabetic Retinopathy Diabetic Eye Disease information page Back to top Glaucoma Glaucoma ...

  6. Diabetic Eye Disease

    Science.gov (United States)

    ... Other Dental Problems Diabetes & Sexual & Urologic Problems Diabetic Eye Disease What is diabetic eye disease? Diabetic eye disease is a group of ... loss can occur. How does diabetes affect my eyes? Diabetes affects your eyes when your blood glucose, ...

  7. Understanding cardiovascular disease

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000759.htm Understanding cardiovascular disease To use the sharing features on this page, ... lead to heart attack or stroke. Types of Cardiovascular Disease Coronary heart disease (CHD) is the most common ...

  8. Menopause and Heart Disease

    Science.gov (United States)

    ... Peripheral Artery Disease Venous Thromboembolism Aortic Aneurysm More Menopause and Heart Disease Updated:Jun 23,2017 Heart ... can become more evident after the onset of menopause. Menopause does not cause cardiovascular diseases . However, certain ...

  9. Cholestatic liver disease masquerading as Wilson disease.

    Science.gov (United States)

    Sood, Vikrant; Rawat, Dinesh; Khanna, Rajeev; Alam, Seema

    2015-03-01

    Wilson disease and cholestatic liver diseases may present as a diagnostic dilemma if standard guidelines incorporating markers of copper overload are followed. We hereby present a series of four cases of sclerosing cholangitis masquerading as Wilson disease. True Wilson disease cases had significantly lower ceruloplasmin (6 vs. 16 mg/dL) and higher 24-hour urinary copper (322.3 vs. 74.5 μg/day) as compared to mimickers. Initial low serum ceruloplasmin levels normalized in mimickers on follow up, and this may used as a diagnostic indicator. Standard Wilson disease diagnostic criteria thus need further modification especially in developing countries to help avoid mismanagement.

  10. Disease cycle approach to plant disease prediction.

    Science.gov (United States)

    De Wolf, Erick D; Isard, Scott A

    2007-01-01

    Plant disease cycles represent pathogen biology as a series of interconnected stages of development including dormancy, reproduction, dispersal, and pathogenesis. The progression through these stages is determined by a continuous sequence of interactions among host, pathogen, and environment. The stages of the disease cycle form the basis of many plant disease prediction models. The relationship of temperature and moisture to disease development and pathogen reproduction serve as the basis for most contemporary plant disease prediction systems. Pathogen dormancy and inoculum dispersal are considered less frequently. We found extensive research efforts evaluating the performance of prediction models as part of operation disease management systems. These efforts appear to be greater than just a few decades ago, and include novel applications of Bayesian decision theory. Advances in information technology have stimulated innovations in model application. This trend must accelerate to provide the disease management strategies needed to maintain global food supplies.

  11. Rheumatoid lung disease

    Science.gov (United States)

    Lung disease - rheumatoid arthritis; Rheumatoid nodules; Rheumatoid lung ... They often cause no symptoms. The cause of lung disease associated with rheumatoid arthritis is unknown. Sometimes, the ...

  12. Liver in systemic disease

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Potential causes of abnormal liver function tests include viral hepatitis, alcohol intake, nonalcoholic fatty liver disease, autoimmune liver diseases, hereditary diseases, hepatobiliary malignancies or infection, gallstones and drug-induced liver injury. Moreover, the liver may be involved in systemic diseases that mainly affect other organs. Therefore, in patients without etiology of liver injury by screening serology and diagnostic imaging, but who have systemic diseases, the abnormal liver function test results might be caused by the systemic disease. In most of these patients, the systemic disease should be treated primarily. However, some patients with systemic disease and severe liver injury or fulminant hepatic failure require intensive treatments of the liver.

  13. Biomarker for Glycogen Storage Diseases

    Science.gov (United States)

    2017-07-03

    Fructose Metabolism, Inborn Errors; Glycogen Storage Disease; Glycogen Storage Disease Type I; Glycogen Storage Disease Type II; Glycogen Storage Disease Type III; Glycogen Storage Disease Type IV; Glycogen Storage Disease Type V; Glycogen Storage Disease Type VI; Glycogen Storage Disease Type VII; Glycogen Storage Disease Type VIII

  14. [Wilson's disease: clinical spectrum of liver disease].

    Science.gov (United States)

    Ochoa Palominos, Alejandra; Ibáñez Samaniego, Luis; Catalina Rodríguez, María-Vega; Pajares Díaz, José; Clemente Ricote, Gerardo

    2013-02-01

    Wilson's disease is a hereditary autosomal recessive disorder of copper metabolism,characterized by copper accumulation in the liver and brain. This rare entity, which has a broad clinical spectrum, is often difficult to diagnose and should therefore always be suspected in patients with liver disease of unclear cause. We describe two types of manifestation of liver disease in two patients; the first developed fulminant hepatic failure requiring urgent liver transplantation and the second showed advanced chronic liver disease and received standard medical treatment. The objective of this clinical observation is to analyze the diagnosis of Wilson's disease in two patients with distinct onset, illustrating the broad clinical spectrum of the disease, and its treatment.

  15. Interstitial Lung Diseases

    Science.gov (United States)

    Interstitial lung disease is the name for a large group of diseases that inflame or scar the lungs. The inflammation and scarring make it hard to ... air is responsible for some types of interstitial lung diseases. Specific types include Black lung disease among ...

  16. What Causes Heart Disease?

    Science.gov (United States)

    ... page from the NHLBI on Twitter. What Causes Heart Disease? Research suggests that coronary heart disease (CHD) begins with damage to the lining and ... causing coronary microvascular disease (MVD). Coronary MVD is heart disease that affects the heart's tiny arteries. The cause ...

  17. PERIANAL CROHNS-DISEASE

    NARCIS (Netherlands)

    HOEDEMAKER, HOT

    1994-01-01

    Perianal disease in Crohn's disease is a difficult matter to deal with. The indication for therapy is not always clear in this disease with a relatively mild natural course. More confusion is caused by the fact that not all disease in the perianal region in a patient with Crohn's has to be Crohn-rel

  18. Occupational skin diseases

    DEFF Research Database (Denmark)

    Mahler, Vera; Aalto-Korte, Kristiina; Alfonso, Jose Hernan

    2017-01-01

    BACKGROUND: Work-related skin diseases (WSD) are caused or worsened by a professional activity. Occupational skin diseases (OSD) need to fulfil additional legal criteria which differ from country to country. OSD range amongst the five most frequently notified occupational diseases (musculoskeletal...... diseases, neurologic diseases, lung diseases, diseases of the sensory organs, skin diseases) in Europe. OBJECTIVE: To retrieve information and compare the current state of national frameworks and pathways to manage patients with occupational skin disease with regard to prevention, diagnosis, treatment...... in Science and Technology (COST) Action TD 1206 (StanDerm) (www.standerm.eu). RESULTS: Besides a national health service or a statutory health insurance, most European member states implemented a second insurance scheme specifically geared at occupational diseases [insurance against occupational risks...

  19. [Periodontal disease in pediatric rheumatic diseases].

    Science.gov (United States)

    Fabri, Gisele M C; Savioli, Cynthia; Siqueira, José T; Campos, Lucia M; Bonfá, Eloisa; Silva, Clovis A

    2014-01-01

    Gingivitis and periodontitis are immunoinflammatory periodontal diseases characterized by chronic localized infections usually associated with insidious inflammation This narrative review discusses periodontal diseases and mechanisms influencing the immune response and autoimmunity in pediatric rheumatic diseases (PRD), particularly juvenile idiopathic arthritis (JIA), childhood-onset systemic lupus erythematosus (C-SLE) and juvenile dermatomyositis (JDM). Gingivitis was more frequently observed in these diseases compared to health controls, whereas periodontitis was a rare finding. In JIA patients, gingivitis and periodontitis were related to mechanical factors, chronic arthritis with functional disability, dysregulation of the immunoinflammatory response, diet and drugs, mainly corticosteroids and cyclosporine. In C-SLE, gingivitis was associated with longer disease period, high doses of corticosteroids, B-cell hyperactivation and immunoglobulin G elevation. There are scarce data on periodontal diseases in JDM population, and a unique gingival pattern, characterized by gingival erythema, capillary dilation and bush-loop formation, was observed in active patients. In conclusion, gingivitis was the most common periodontal disease in PRD. The observed association with disease activity reinforces the need for future studies to determine if resolution of this complication will influence disease course or severity.

  20. Huntington’s Disease

    Science.gov (United States)

    2012-05-01

    New advances in disease testing and diagnosis, such as genetic testing , now provide increased means for disease diagnosis but also possible therapeutic...treatments. Indeed, according to some experts, genetic testing and therapy may be key to future disease detection, therapy, and even prevention. In...associated with its long-term management. 15. SUBJECT TERMS Neurological disease , genetic testing , aeromedical concerns, Huntington’s disease 16

  1. Genetic diseases in adults.

    Science.gov (United States)

    Kolettis, Peter N

    2003-02-01

    Genetic diseases that do not primarily affect the genitourinary tract may have urologic manifestations. These urologic manifestations range from benign and malignant renal disease to infertility. Thus, the practicing urologist may be involved in the care of these patients and should have knowledge of these diseases. Continued improvements in the diagnosis and treatment of these genetic diseases will likely result in improved survival and will increase the number of patients who may develop urologic manifestations of these diseases.

  2. Pregnancy and periodontal disease

    OpenAIRE

    SAĞLAM, Ebru; SARUHAN, Nesrin; Çanakçı, Cenk Fatih

    2015-01-01

    Some maternal immunological changes due to pregnancy increases susceptibility to infections. Periodontal disease, the main cause is plaque, is a common disease which is seen multifactorial and varying severity. There are many clinical criteria for diagnosis of periodontal disease. Correlation between pregnancy and periodontal inflammation is known for many years. Periodontal disease affects pregnant’s systemic condition and also has negative effects on fetus. Periodontal disease increases the...

  3. The Relationship Between Fatty Liver Disease and Periodontal Disease

    Science.gov (United States)

    2017-03-22

    Periodontitis is a highly prevalent and destructive chronic disease. Numerous studies support an association between periodontal disease and other...systemic diseases ( diabetes , cardiovascular disease, chronic kidney disease, adverse pregnancy outcome, etc.). Non-alcoholic fatty liver disease is a...destruction seen in periodontal disease. The association between the two diseases has never been investigated. A reasonable mechanism in which periodontal

  4. Evaluation of the immunoexpression of COX-1, COX-2 and p53 in Crohn's disease Avaliação da imunoexpressão de COX-1, COX-2 e p53 na doença de Crohn

    Directory of Open Access Journals (Sweden)

    Mônica Romero

    2008-12-01

    Full Text Available BACKGROUND: Crohn's disease accompanied by nonspecific or idiopathic ulcerative proctocolitis corresponds to a condition called intestinal inflammatory disease. The immunoexpression of cyclooxygenase 2 (COX-2 in Crohn's disease becomes more marked with progression of the disease and the presence of wild-type p53 suppresses the transcription of COX-2. AIMS: To investigate the immunoexpression of cyclooxygenase 1 (COX-1, COX-2 and p53 in Crohn's ileocolitis and to correlated this expression with clinical and histopathological parameters. METHODS: Forty-five cases of Crohn's disease, 16 cases of actinic colitis (diseased-control group and 11 cases without a history of intestinal disease (normal control group were studied. Hematoxylin-eosin-stained sections were submitted to histopathological analysis and the immunohistochemical expression of COX-1, COX-2 and p53 was evaluated by the streptavidin-biotin-peroxidase method. RESULTS: Sixty percent of the Crohn's disease patients were women and 40% were men, with 75.5% whites and 25.5% non-whites. The disease involved the terminal ileum in 44.5% of cases, ileum in 33.3%, colon in 20% and duodenum-ileum in 2.2%. A significant association was observed between COX-2 immunoreactivity and age RACIONAL: A doença de Crohn, junto com a colite ulcerativa idiopática ou inespecífica constituem a doença inflamatória intestinal. A imunoexpressão de ciclooxigenase 2 (COX-2 na doença de Crohn acentua-se com a progressão da doença, enquanto que a presença do tipo selvagem de p53 suprime a transcrição de COX-2. OBJETIVOS: Investigar a imunoexpressão de ciclooxigenase 1 (COX-1, COX-2 e p53 na doença de Crohn e correlacionar os achados com parâmetros clínico-histopatológicos. MÉTODOS: Foram estudados 45 casos de doença de Crohn (grupo teste, 16 casos de colite actínica (grupo controle-doente e 11 casos sem história de doença intestinal (grupo controle normal. A avaliação histopatológica foi feita

  5. O poder de fogo da relação educativa na mira de novos e velhos prometeus

    Directory of Open Access Journals (Sweden)

    Belintane Claudemir

    1998-01-01

    Full Text Available O presente trabalho enfoca a relação educativa no contexto da escola pública das periferias dos centros urbanos, procurando distinguir uma certa indisciplina e até mesmo um certo tipo de violência inerente ao próprio entrechoque civilizatório que o ato educativo, em geral, pressupõe, de outro tipo de violência social mais contundente, arredia à escolarização. O autor lança mão de duas experiências pessoais vividas em escolas distintas: uma escola da periferia da Grande São Paulo, onde a violência, no interior da escola, atinge níveis acima do tolerável, e uma outra escola, tradicional de classe média, na qual também ocorre um certo tipo de violência. Acrescenta ainda ao esquema comparativo algumas reflexões oriundas de um enfoque psicanalítico institucional, procurando demonstrar a conjunção de forças inconscientes na construção do pacto mínimo para o estabelecimento de relações educativas.

  6. ÍNDICES DE RISCO DE FOGO DE HAINES E SETZER EM DIFERENTES CONDIÇÕES CLIMÁTICAS

    Directory of Open Access Journals (Sweden)

    Anailton Sales de Melo

    2012-01-01

    Full Text Available Los incendios a nivel mundial, son la segunda fuente de emisiones de gases de efecto invernadero (GEI. Teniendo en cuenta la necesidad de conocer las posibles implicaciones de los cambios en la circulación atmosférica en el futuro cercano, tenemos la intención de este trabajo para investigar la susceptibilidad del medio ambiente al fuego sobre la base de las tasas de riesgo de incendios, a saber, el índice de Haines (IH y el Índice de Setzer (IS. Para ello, el modelo de datos ECHAM5/MPI-OM modelación numérica, y los datos del reanálisis del NCEP se utilizan en el cálculo de (IH y (IS en dos períodos: las proyecciones actuales (1980-2000 y el clima para el fi n siglo (2080-2100. Basándose en los resultados, se concluye que los modelos de riesgo de incendios se reproducen bien las zonas con mayor incidencia de los incendios en las condiciones actuales y que, en condiciones de calentamiento global ha detectado un aumento en el área de riesgo, en particular, en la región amazónica a lo IS.

  7. Bullet embolism of pulmonary artery: a case report; Embolia pulmonar por projetil de arma de fogo: relato de caso

    Energy Technology Data Exchange (ETDEWEB)

    Yamanari, Mauricio Gustavo Ieiri; Mansur, Maria Clara Dias; Kay, Fernando Uliana; Silverio, Paulo Rogerio Barboza; Jayanthi, Shri Krishna; Funari, Marcelo Buarque de Gusmao, E-mail: mauriciogustavo91@yahoo.com.br [Universidade de Sao Paulo (IHC-FMUSP), SP (Brazil). Faculdade de Medicina. Hospital das Clinicas

    2014-03-15

    The authors report the case of a patient victim of gunshots, with a very rare complication: venous bullet embolism from the left external iliac vein to the lingular segment of the left pulmonary artery. Diagnosis is made with whole-body radiography or computed tomography. Digital angiography is reserved for supplementary diagnosis or to be used as a therapeutic procedure. (author)

  8. Tay-Sachs Disease

    Science.gov (United States)

    ... Craniosynostosis Information Page Creutzfeldt-Jakob Disease Information Page Cushing's Syndrome Information Page Dandy-Walker Syndrome Information Page Deep Brain Stimulation for Parkinson's Disease Information Page Dementia Information ...

  9. Infantile Refsum Disease

    Science.gov (United States)

    ... Craniosynostosis Information Page Creutzfeldt-Jakob Disease Information Page Cushing's Syndrome Information Page Dandy-Walker Syndrome Information Page Deep Brain Stimulation for Parkinson's Disease Information Page Dementia Information ...

  10. What Is Kawasaki Disease?

    Science.gov (United States)

    ANSWERS by heart Cardiovascular Conditions What is Kawasaki Disease? Kawasaki disease is a children’s illness. It’s also known as Kawasaki syndrome or mucocutaneous lymph node syndrome. About 75 percent of people ...

  11. Mitral Valve Disease

    Science.gov (United States)

    ... for more information on procedures, news, and pre- & post-operative care. Section Navigation Select Topic Aortic Valve Disease ... is most commonly caused by inflammation from rheumatic fever, a disease that is related to strep infections; ...

  12. Treatments for Alzheimer's Disease

    Science.gov (United States)

    ... 3900 Find your chapter: search by state Home > Alzheimer's Disease > Treatments Overview What Is Dementia? What Is Alzheimer's? ... and move closer to a cure. Treatments for Alzheimer's disease Currently, there is no cure for Alzheimer's. But ...

  13. Heart Diseases--Prevention

    Science.gov (United States)

    ... you have a close family member who had heart disease at an early age. Fortunately, there are many things you can do reduce your chances of getting heart disease. You should Know your blood pressure and keep ...

  14. Lyme disease antibody

    Science.gov (United States)

    ... JavaScript. The Lyme disease blood test looks for antibodies in the blood to the bacteria that causes ... needed. A laboratory specialist looks for Lyme disease antibodies in the blood sample using the ELISA test . ...

  15. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Care: Real Stories Betsaida Cruz, PT, Long Beach Memorial Medicinal: “Terapia fisica para el Parkinson” Building a ... and Social Network? How Does Parkinson's Disease Affect Memory? How Does Parkinson's Disease Affect the Urinary System? ...

  16. Addison's Disease: Treatment

    Science.gov (United States)

    Addison's disease Diagnosis Your doctor will talk to you first about your medical history and your signs and ... If your doctor thinks that you may have Addison's disease, you may undergo some of the following tests: ...

  17. Alcoholic liver disease

    Science.gov (United States)

    Liver disease due to alcohol; Cirrhosis or hepatitis - alcoholic; Laennec's cirrhosis ... Alcoholic liver disease occurs after years of heavy drinking. Over time, scarring and cirrhosis can occur. Cirrhosis is the ...

  18. Chronic granulomatous disease

    Science.gov (United States)

    CGD; Fatal granulomatosis of childhood; Chronic granulomatous disease of childhood; Progressive septic granulomatosis ... In chronic granulomatous disease (CGD), immune system cells called phagocytes are unable to kill some types of bacteria and ...

  19. Valvular heart disease

    OpenAIRE

    Gelson, E; Gatzoulis, M; Johnson, M.

    2007-01-01

    Valvular disease may be unmasked in pregnancy when physiological changes increase demands on the heart. Women with valvular heart disease require close follow-up during pregnancy, delivery, and postpartum

  20. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Use for Freezing? Are There Any Ways to Control the Rate of Progression of the Disease? Ask ... Memory? How Does Parkinson's Disease Affect the Urinary System? How Does Speech Therapy Help Parkinson's Patients? How ...

  1. Celiac disease - nutritional considerations

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/002443.htm Celiac disease - nutritional considerations To use the sharing features on this page, please enable JavaScript. Celiac disease is an immune disorder passed down through families. ...

  2. Hypothyroidism and Heart Disease

    Science.gov (United States)

    ... in Balance › Hypothyroidism and Heart Disease Fact Sheet Hypothyroidism and Heart Disease January 2014 Download PDFs English ... nervous system, body temperature, and weight. What is hypothyroidism and what are its symptoms? Hypothyroidism, also called ...

  3. Genetic Disease Foundation

    Science.gov (United States)

    ... mission to help prevent, manage and treat inherited genetic diseases. View our latest News Brief here . You can ... contributions to the diagnosis, prevention and treatment of genetic diseases. Learn how advances at Mount Sinai have impacted ...

  4. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Sexual Functioning? How Does Depression Affect the Patient's Family and Social Network? How Does Parkinson's Disease Affect Memory? How Does Parkinson's Disease Affect the Urinary System? How Does Speech Therapy Help Parkinson's Patients? How ...

  5. Pediatric inflammatory bowel disease

    Institute of Scientific and Technical Information of China (English)

    Karen A Diefenbach; Christopher K Breuer

    2006-01-01

    Inflammatory bowel disease is an important cause of gastrointestinal pathology in children and adolescents.The incidence of pediatric inflammatory bowel disease is increasing; therefore, it is important for the clinician to be aware of the presentation of this disease in the pediatric population. Laboratory tests, radiology studies,and endoscopic procedures are helpful in diagnosing inflammatory bowel disease and differentiating between Crohn's disease and ulcerative colitis. Once diagnosed,the goal of medical management is to induce remission of disease while minimizing the side effects of the medication. Specific attention needs to be paid to achieving normal growth in this susceptible population.Surgical management is usually indicated for failure of medical management, complication, or malignancy.Algorithms for diagnostic evaluation and treatment of pediatric inflammatory bowel disease are presented.The specific psychosocial issues facing these patients are also discussed in this review as are the future goals of research in the complex problem of pediatric inflammatory bowel disease.

  6. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Disease Nutrition Matters Speech and Swallowing Psychosis: A Mind Guide to Parkinson's Disease Guide to Deep Brain Stimulation You Can Make A Difference Your donation to the National Parkinson Foundation goes ...

  7. American Behcet's Disease Association

    Science.gov (United States)

    ... Behcet's Awareness Day Behcet's Disease Awareness Share your story and educate others about Behcet's: www.rareconnect.org/en/community/behcet-s-syndrome Upcoming Events American Behcet's Disease Association PO BOX 80576 Rochester, MI ...

  8. What Is Parkinson's Disease?

    Science.gov (United States)

    ... million people in the US are living with Parkinson's disease. The cause is unknown, and although there is presently no ... a Diagnosis What is Parkinson’s Disease? ... Trials Statistics on Parkinson's What's New In Parkinson's Research? What's in the ...

  9. Sickle Cell Disease

    Science.gov (United States)

    ... About Us Overview of CDC’s work. Advancements in Sickle Cell Disease New supplement from the American Journal of Preventive Medicine describes the state of sickle cell disease related care in the United States. Read Supplement ...

  10. Learning about Huntington's Disease

    Science.gov (United States)

    ... Mouse Models Of Huntington's Disease 1998 News Release Learning About Huntington's Disease What do we know about ... and treatment information. Hosted by the Dolan DNA Learning Center at Cold Spring Harbor Laboratory. Huntington's Outreach ...

  11. Congenital heart disease

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/001114.htm Congenital heart disease To use the sharing features on this page, please enable JavaScript. Congenital heart disease (CHD) is a problem with the heart's structure ...

  12. Aspirin and heart disease

    Science.gov (United States)

    ... medlineplus.gov/ency/patientinstructions/000092.htm Aspirin and heart disease To use the sharing features on this page, ... healthy people who are at low risk for heart disease. You provider will consider your overall medical condition ...

  13. Cyanotic heart disease

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/001104.htm Cyanotic heart disease To use the sharing features on this page, please enable JavaScript. Cyanotic heart disease refers to a group of many different heart ...

  14. Managing Your Parkinson's Disease

    Science.gov (United States)

    ... Patient Advocates Sign Up for Funding News npj Parkinson's Disease Scientific Advisory Board Understanding Parkinson's Coping with a Diagnosis What is Parkinson’s Disease? National HelpLine Educational Publications Online Seminars Parkinson's News ...

  15. Pain in Parkinson's Disease

    Science.gov (United States)

    ... Patient Advocates Sign Up for Funding News npj Parkinson's Disease Scientific Advisory Board Understanding Parkinson's Coping with a Diagnosis What is Parkinson’s Disease? National HelpLine Educational Publications Online Seminars Parkinson's News ...

  16. Parkinson's Disease Foundation Newsletter

    Science.gov (United States)

    ... Patient Advocates Sign Up for Funding News npj Parkinson's Disease Scientific Advisory Board Understanding Parkinson's Coping with a Diagnosis What is Parkinson’s Disease? National HelpLine Educational Publications Online Seminars Parkinson's News ...

  17. Parkinson's Disease Foundation

    Science.gov (United States)

    ... Patient Advocates Sign Up for Funding News npj Parkinson's Disease Scientific Advisory Board Understanding Parkinson's Coping with a Diagnosis What is Parkinson’s Disease? National HelpLine Educational Publications Online Seminars Parkinson's News ...

  18. Diabetes and Kidney Disease

    Science.gov (United States)

    ... disease of diabetes, or diabetic nephropathy. How does diabetes cause kidney disease? High blood glucose , also called ... I keep my kidneys healthy if I have diabetes? The best way to slow or prevent diabetes- ...

  19. Pediatric Celiac Disease

    Science.gov (United States)

    ... Free Diet Guide Eosinophilic Esophagitis Inflammatory Bowel Disease Nutrition & Obesity Reflux & GERD Search Keyword Connect with Facebook Additional ... Nutrition (NASPGHAN) Celiac Disease Eosinophilic Esophagitis Pediatric IBD Nutrition & Obesity Reflux & GERD Research & Grants Our Supporters Site Map © ...

  20. Chronic Kidney Diseases

    Science.gov (United States)

    ... Room? What Happens in the Operating Room? Chronic Kidney Diseases KidsHealth > For Kids > Chronic Kidney Diseases Print ... re talking about your kidneys. What Are the Kidneys? Your kidneys are tucked under your lower ribs ...

  1. Polycystic kidney disease

    Science.gov (United States)

    Cysts - kidneys; Kidney - polycystic; Autosomal dominant polycystic kidney disease; ADPKD ... Polycystic kidney disease (PKD) is passed down through families (inherited). The 2 inherited forms of PKD are autosomal dominant ...

  2. Kidney Disease Basics

    Science.gov (United States)

    ... Links Take the first step Alternate Language URL Kidney Disease Basics Page Content Your kidneys filter extra ... blood pressure are the most common causes of kidney disease. ​These conditions can slowly damage the kidneys ...

  3. Diet - chronic kidney disease

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/002442.htm Diet - chronic kidney disease To use the sharing features on this page, ... make changes to your diet when you have chronic kidney disease. These changes may include limiting fluids, eating a ...

  4. Feline corneal disease.

    Science.gov (United States)

    Moore, Phillip Anthony

    2005-05-01

    The cornea is naturally transparent. Anything that interferes with the cornea's stromal architecture, contributes to blood vessel migration, increases corneal pigmentation, or predisposes to corneal edema, disrupts the corneas transparency and indicates corneal disease. The color, location, and shape and pattern of a corneal lesion can help in determining the underlying cause for the disease. Corneal disease is typically divided into congenital or acquired disorders. Congenital disorders, such as corneal dermoids are rare in cats, whereas acquired corneal disease associated with nonulcerative or ulcerative keratitis is common. Primary ocular disease, such as tear film instability, adenexal disease (medial canthal entropion, lagophthalmus, eyelid agenesis), and herpes keratitis are associated with the majority of acquired corneal disease in cats. Proliferative/eosinophilic keratitis, acute bullous keratopathy, and Florida keratopathy are common feline nonulcerative disorders. Nonprogressive ulcerative disease in cats, such as chronic corneal epithelial defects and corneal sequestration are more common than progressive corneal ulcerations.

  5. Carotid Artery Disease

    Science.gov (United States)

    ... Kawasaki Disease Long Q-T Syndrome Marfan Syndrome Metabolic Syndrome Mitral Valve Prolapse Myocardial Bridge Myocarditis Obstructive Sleep Apnea Pericarditis Peripheral Vascular Disease Rheumatic Fever Sick Sinus Syndrome Silent Ischemia Stroke Sudden ...

  6. Creutzfeldt-Jakob disease

    Science.gov (United States)

    ... part of a funeral ritual) Scrapie (found in sheep) Other very rare inherited human diseases, such as ... markers that sometimes occur with the disease CT scan of the brain Electroencephalogram (EEG) MRI of the ...

  7. Autoimmune Inner Ear Disease

    Science.gov (United States)

    ... Find an ENT Doctor Near You Autoimmune Inner Ear Disease Autoimmune Inner Ear Disease Patient Health Information ... with a hearing loss. How Does the Healthy Ear Work? The ear has three main parts: the ...

  8. [Depression and neurological diseases].

    Science.gov (United States)

    Piber, D; Hinkelmann, K; Gold, S M; Heesen, C; Spitzer, C; Endres, M; Otte, C

    2012-11-01

    In many neurological diseases a depressive syndrome is a characteristic sign of the primary disease or is an important comorbidity. Post-stroke depression, for example, is a common and relevant complication following ischemic brain infarction. Approximately 4 out of every 10 stroke patients develop depressive disorders in the course of the disease which have a disadvantageous effect on the course and the prognosis. On the other hand depression is also a risk factor for certain neurological diseases as was recently demonstrated in a meta-analysis of prospective cohort studies which revealed a much higher stroke risk for depressive patients. Furthermore, depression plays an important role in other neurological diseases with respect to the course and quality of life, such as Parkinson's disease, multiple sclerosis and epilepsy. This article gives a review of the most important epidemiological, pathophysiological and therapeutic aspects of depressive disorders as a comorbidity of neurological diseases and as a risk factor for neurological diseases.

  9. Sickle Cell Disease Quiz

    Science.gov (United States)

    ... Websites About Us Information For... Media Policy Makers Sickle Cell Disease Quiz Language: English Español (Spanish) Recommend on ... 1. True or False: Only African Americans get sickle cell disease. A True B False 2. True or ...

  10. Degenerative Nerve Diseases

    Science.gov (United States)

    Degenerative nerve diseases affect many of your body's activities, such as balance, movement, talking, breathing, and heart function. Many of these diseases are genetic. Sometimes the cause is a medical ...

  11. Sexually Transmitted Diseases

    Science.gov (United States)

    Sexually transmitted diseases (STDs) are infections that are passed from one person to another through sexual contact. The causes of STDs ... often help with the symptoms and keep the disease under control. Correct usage of latex condoms greatly ...

  12. Celiac disease - sprue

    Science.gov (United States)

    ... Gluten intolerance; Gluten-sensitive enteropathy; Gluten-free diet celiac disease ... The exact cause of celiac disease is unknown. The lining of the intestines have small areas called villi which project outward into the opening of the ...

  13. Celiac Disease Tests

    Science.gov (United States)

    ... AACC products and services. Advertising & Sponsorship: Policy | Opportunities Celiac Disease Antibody Tests Share this page: Was this page ... else I should know? How is it used? Celiac disease antibody tests are primarily used to help diagnose ...

  14. Coronary Artery Disease

    Science.gov (United States)

    Coronary artery disease (CAD) is the most common type of heart disease. It is the leading cause of death ... happens when the arteries that supply blood to heart muscle become hardened and narrowed. This is due ...

  15. Women and Parasitic Diseases

    Science.gov (United States)

    ... Resources How to Find A Physician Diagnosis of Parasitic Diseases Statistics More Information Get Email Updates To receive ... often need special consideration when being treated for parasitic diseases in order to avoid harm to the fetus, ...

  16. Diagnosis of Parasitic Diseases

    Science.gov (United States)

    ... Laboratory Diagnostic Assistance [DPDx] Parasites Home Diagnosis of Parasitic Diseases Recommend on Facebook Tweet Share Compartir On this ... the United States cannot diagnose parasites? How are parasitic diseases diagnosed? Many kinds of lab tests are available ...

  17. Collagen vascular disease

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/001223.htm Collagen vascular disease To use the sharing features on this ... previously said to have "connective tissue" or "collagen vascular" disease. We now have names for many specific ...

  18. Pelizaeus-Merzbacher Disease

    Science.gov (United States)

    ... diseases associated with PLP1, which also includes Spastic Paraplegia Type 2 (SPG2). The PLP1-related disorders span ... diseases associated with PLP1, which also includes Spastic Paraplegia Type 2 (SPG2). The PLP1-related disorders span ...

  19. Lewy Body Disease

    Science.gov (United States)

    Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss ... enough to affect normal activities and relationships. Lewy body disease happens when abnormal structures, called Lewy bodies, ...

  20. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Parkinson's Disease Affect the Urinary System? How Does Speech Therapy Help Parkinson's Patients? How Does the DBS ... A Mind Guide to Parkinson’s Disease Nutrition Matters Speech and Swallowing Psychosis: A Mind Guide to Parkinson's ...

  1. APOE Genotyping, Cardiovascular Disease

    Science.gov (United States)

    ... Home Visit Global Sites Search Help? APOE Genotyping, Cardiovascular Disease Share this page: Was this page helpful? Also ... of choice to decrease the risk of developing cardiovascular disease (CVD) . However, there is a wide variability in ...

  2. [Emerging noninfectious diseases].

    Science.gov (United States)

    Consiglio, Ezequiel

    2008-11-01

    In recent years, emerging diseases were defined as being infectious, acquiring high incidence, often suddenly, or being a threat or an unexpected phenomenon. This study discusses the hallmarks of emerging diseases, describing the existence of noninfectious emerging diseases, and elaborating on the advantages of defining noninfectious diseases as emerging ones. From the discussion of various mental health disorders, nutritional deficiencies, external injuries and violence outcomes, work injuries and occupational health, and diseases due to environmental factors, the conclusion is drawn that a wide variety of noninfectious diseases can be defined as emergent. Noninfectious emerging diseases need to be identified in order to improve their control and management. A new definition of "emergent disease" is proposed, one that emphasizes the pathways of emergence and conceptual traits, rather than descriptive features.

  3. Sniffing out disease

    NARCIS (Netherlands)

    Jansen, R.M.C.

    2007-01-01

    Research from Holland on early identification on plant disease from odours, provides a potential disease managment tool in glasshouses. Combined with precision technology could these techniques be of relevance to paddock production?

  4. Lyme Disease Data

    Science.gov (United States)

    ... Lyme disease FAQ Health care providers Educational materials Data and Statistics Recommend on Facebook Tweet Share Compartir ... in the northeast and upper Midwest. Lyme Disease Data File To facilitate the public health and research ...

  5. Self Inflicted Dermatological Diseases

    Directory of Open Access Journals (Sweden)

    Ertuğrul H. Aydemir

    2010-07-01

    Full Text Available This group of diseases are characterised with the aggravated types of stress releasing behaviors like scratching, picking, squeezing, and sucking. Lichen simplex chronicus, prurigo nodularis, neurotic excoriations, trichotillomani, and onychotillomani are the diseases in this group. Depression, anxiety, and obsesif compulsive disease are the main underlying psychologic diseases. They need a skillfull psychiatric approach in addition to dermatologic treatment, and should be treated with patience in a long duration.

  6. Functional bowel disease

    DEFF Research Database (Denmark)

    Rumessen, J J; Gudmand-Høyer, E

    1988-01-01

    Twenty-five patients with functional bowel disease were given fructose, sorbitol, fructose-sorbitol mixtures, and sucrose. The occurrence of malabsorption was evaluated by means of hydrogen breath tests and the gastrointestinal symptoms, if any, were recorded. One patient could not be evaluated...... with functional bowel disease. The findings may have direct influence on the dietary guidance given to a major group of patients with functional bowel disease and may make it possible to define separate entities in this disease complex....

  7. Genetics of complex diseases.

    Science.gov (United States)

    Motulsky, Arno G

    2006-02-01

    Approaches to the study of the genetic basis of common complex diseases and their clinical applications are considered. Monogenic Mendelian inheritance in such conditions is infrequent but its elucidation may help to detect pathogenic mechanisms in the more common variety of complex diseases. Involvement by multiple genes in complex diseases usually occurs but the isolation and identification of specific genes so far has been exceptional. The role of common polymorphisms as indicators of disease risk in various studies is discussed.

  8. Spinal Cord Diseases

    Science.gov (United States)

    ... damages the vertebrae or other parts of the spine, this can also injure the spinal cord. Other spinal cord problems include Tumors Infections such as meningitis and polio Inflammatory diseases Autoimmune diseases Degenerative diseases such as amyotrophic lateral sclerosis and spinal ...

  9. Kawasaki Disease (For Parents)

    Science.gov (United States)

    ... Teaching Kids to Be Smart About Social Media Kawasaki Disease KidsHealth > For Parents > Kawasaki Disease Print A A A What's in this ... Complications Diagnosis Treatment en español La enfermedad de Kawasaki Kawasaki disease is an illness that involves the ...

  10. What Is Crohn's Disease?

    Science.gov (United States)

    ... What are Crohn's & Colitis? > What is Crohn’s Disease? Crohn’s Disease is a Chronic Condition By understanding your body ... live a full and rewarding life What is Crohn’s Disease? Email Print + Share Named after Dr. Burrill B. ...

  11. Lung Diseases and Conditions

    Science.gov (United States)

    ... Share this page from the NHLBI on Twitter. Lung Diseases and Conditions Breathing is a complex process. If ... to a disease called COPD (chronic obstructive pulmonary disease). COPD prevents proper airflow in and out of your lungs and can hinder gas exchange in the air ...

  12. Bacterial diseases affecting apple

    Science.gov (United States)

    Bacterial diseases of plants are usually difficult to control and often require a combination of control measures to successfully manage the disease. There are often stark differences between the means available to control bacterial diseases in annual crops versus a woody tree crop, such as apple. ...

  13. Pompe disease: clinical perspectives

    Directory of Open Access Journals (Sweden)

    Cabello JF

    2016-12-01

    Full Text Available Juan Francisco Cabello,1 Deborah Marsden21Genetics and Metabolic Disease Laboratory, Nutrition and Food Technology Institute (INTA, University of Chile, Santiago, Chile; 2Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA Abstract: Pompe disease (acid alpha-glucosidase deficiency, OMIM 232300 is a rare lysosomal storage disorder due to autosomal recessive mutations in the GAA gene. It has also been called acid maltase deficiency and glycogen storage disease type II. There is a broad clinical presentation: the most severe form that presents in the first few months of life with cardiomyopathy and generalized muscle weakness that rapidly progresses to death from cardio-respiratory failure in the first year of life (infant-onset Pompe disease. A more slowly progressive disease, with little or no cardiac involvement, presents with proximal myopathy and/or pulmonary insufficiency, from the second year of life to late adulthood (late-onset Pompe disease. The recent development and introduction of enzyme replacement therapy with intravenous infusion of recombinant human acid alpha-glucosidase have made a major improvement in the morbidity and mortality of this disease. New therapies are also in development. With the availability of treatment, diagnostic methods have also improved, allowing for earlier recognition and potential early therapeutic intervention. The advent of newborn screening for Pompe disease may identify patients who can be treated before significant irreversible disease has occurred. Keywords: Pompe disease, glycogen storage disease, lysosomal storage disease, enzyme replacement therapy, gene therapy, chaperone therapy, genotype/phenotype, newborn screening

  14. Venereal Disease Education.

    Science.gov (United States)

    Lama, Jerry

    This speech on venereal disease education uses as its focus this quotation from George Santayana, "Those who cannot remember the past are doomed to repeat it." The author presents a brief history of venereal disease education and statistics on the present rate of venereal disease. He concludes that past research and experience indicate that…

  15. Research Areas: Liver Disease

    Science.gov (United States)

    ... and C, or by genetic mutations. Other liver diseases can be triggered by autoimmune reactions or drug toxicity. The rise in obesity in the United States has led to a rise in nonalcoholic fatty liver disease. Many liver diseases place individuals at higher risk ...

  16. Heart Disease in Women

    Science.gov (United States)

    ... United States, 1 in 4 women dies from heart disease. The most common cause of heart disease in both men and women is narrowing or ... It's the major reason people have heart attacks. Heart diseases that affect women more than men include Coronary ...

  17. Living with Heart Disease

    Science.gov (United States)

    ... page from the NHLBI on Twitter. Living With Heart Disease If you have coronary heart disease (CHD), you can take steps to control its ... the section of this article titled "How Is Heart Disease Treated?" You also can visit the Health Topics ...

  18. Huntington's disease phenocopy syndromes.

    Science.gov (United States)

    Wild, Edward J; Tabrizi, Sarah J

    2007-12-01

    Patients presenting with features of Huntington's disease but lacking the causative genetic expansion can be challenging diagnostically. The differential diagnosis of such Huntington's disease phenocopy syndromes has not recently been reviewed. Cohort studies have established the relative frequencies of known Huntington's disease phenocopy syndromes, whereas newly described ones have been characterized genetically, clinically, radiologically and pathologically. About 1% of suspected Huntington's disease cases emerge as phenocopy syndromes. Such syndromes are clinically important in their own right but may also shed light on the pathogenesis of Huntington's disease. Huntington's disease produces a range of clinical phenotypes, and the range of syndromes that may be responsible for Huntington's disease phenocopies is correspondingly wide. Cohort studies have established that, while the majority of phenocopy patients remain undiagnosed, in those patients where a genetic diagnosis is reached the commonest causes are SCA17, Huntington's disease-like syndrome 2 (HDL2), familial prion disease and Friedreich's ataxia. We review the features of the reported genetic causes of Huntington's disease phenocopy syndromes, including HDL1-3, SCA17, familial prion disease, spinocerebellar ataxias, dentatorubral-pallidoluysian atrophy, chorea-acanthocytosis and iron-accumulation disorders. We present an evidence-based framework for the genetic testing of Huntington's disease phenocopy cases.

  19. Epilepsy is a disease!

    Directory of Open Access Journals (Sweden)

    Walter Oleschko Arruda

    1994-12-01

    Full Text Available According to the definition of disease, epilepsy shall not be considered neither a symptom nor a syndrome. Epilepsy is a generic term for a group of diseases characterized by seizures. It implies a state quite distinct from health. Therefore it seems worthy to keep epilepsy as such in the International Classification of Diseases (ICD.

  20. Acid Lipase Disease

    Science.gov (United States)

    ... Page You are here Home » Disorders » All Disorders Acid Lipase Disease Information Page Acid Lipase Disease Information Page What research is being ... research to understand lipid storage diseases such as acid lipase deficiency. Additional research studies hope to identify ...

  1. Glycation in Parkinson's disease and Alzheimer's disease.

    Science.gov (United States)

    Vicente Miranda, Hugo; El-Agnaf, Omar M A; Outeiro, Tiago Fleming

    2016-06-01

    Glycation is a spontaneous age-dependent posttranslational modification that can impact the structure and function of several proteins. Interestingly, glycation can be detected at the periphery of Lewy bodies in the brain in Parkinson's disease. Moreover, α-synuclein can be glycated, at least under experimental conditions. In Alzheimer's disease, glycation of amyloid β peptide exacerbates its toxicity and contributes to neurodegeneration. Recent studies establish diabetes mellitus as a risk factor for several neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. However, the mechanisms underlying this connection remain unclear. We hypothesize that hyperglycemia might play an important role in the development of these disorders, possibly by also inducing protein glycation and thereby dysfunction, aggregation, and deposition. Here, we explore protein glycation as a common player in Parkinson's and Alzheimer's diseases and propose it may constitute a novel target for the development of strategies for neuroprotective therapeutic interventions. © 2016 International Parkinson and Movement Disorder Society.

  2. Rapidly progressive Alzheimer disease.

    Science.gov (United States)

    Schmidt, Christian; Wolff, Martin; Weitz, Michael; Bartlau, Thomas; Korth, Carsten; Zerr, Inga

    2011-09-01

    Different rates of progression have been observed among patients with Alzheimer disease. Risk factors that accelerate deterioration have been identified and some are being discussed, such as genetics, comorbidity, and the early appearance of Alzheimer disease motor signs. Progressive forms of Alzheimer disease have been reported with rapid cognitive decline and disease duration of only a few years. This short review aims to provide an overview of the current knowledge of rapidly progressive Alzheimer disease. Furthermore, we suggest that rapid, in this context, should be defined as a Mini-Mental State Examination score decrease of 6 points per year.

  3. Meditation and neurodegenerative diseases.

    Science.gov (United States)

    Newberg, Andrew B; Serruya, Mijail; Wintering, Nancy; Moss, Aleezé Sattar; Reibel, Diane; Monti, Daniel A

    2014-01-01

    Neurodegenerative diseases pose a significant problem for the healthcare system, doctors, and patients. With an aging population, more and more individuals are developing neurodegenerative diseases and there are few treatment options at the present time. Meditation techniques present an interesting potential adjuvant treatment for patients with neurodegenerative diseases and have the advantage of being inexpensive, and easy to teach and perform. There is increasing research evidence to support the application of meditation techniques to help improve cognition and memory in patients with neurodegenerative diseases. This review discusses the current data on meditation, memory, and attention, and the potential applications of meditation techniques in patients with neurodegenerative diseases.

  4. Human Environmental Disease Network

    DEFF Research Database (Denmark)

    Taboureau, Olivier; Audouze, Karine

    2017-01-01

    During the past decades, many epidemiological, toxicological and biological studies have been performed to assess the role of environmental chemicals as potential toxicants for diverse human disorders. However, the relationships between diseases based on chemical exposure have been rarely studied...... by computational biology. We developed a human environmental disease network (EDN) to explore and suggest novel disease-disease and chemical-disease relationships. The presented scored EDN model is built upon the integration on systems biology and chemical toxicology using chemical contaminants information...

  5. Genetics of complex diseases

    DEFF Research Database (Denmark)

    Mellerup, Erling; Møller, Gert Lykke; Koefoed, Pernille

    2012-01-01

    A complex disease with an inheritable component is polygenic, meaning that several different changes in DNA are the genetic basis for the disease. Such a disease may also be genetically heterogeneous, meaning that independent changes in DNA, i.e. various genotypes, can be the genetic basis...... for the disease. Each of these genotypes may be characterized by specific combinations of key genetic changes. It is suggested that even if all key changes are found in genes related to the biology of a certain disease, the number of combinations may be so large that the number of different genotypes may be close...

  6. Radiotherapy of benign diseases

    Energy Technology Data Exchange (ETDEWEB)

    Haase, W.

    1982-10-11

    Still today radiotherapy is of decisive relevance for several benign diseases. The following ones are briefly described in this introductory article: 1. Certain inflammatory and degenerative diseases as furuncles in the face, acute thrombophlebitis, recurrent pseudoriparous abscesses, degenerative skeletal diseases, cervical syndrome and others; 2. rheumatic joint diseases; 3. Bechterew's disease; 4. primary presenile osteoporosis; 5. syringomyelia; 6. endocrine ophthalmopathy; 7. hypertrophic processes of the connective tissue; 8. hemangiomas. A detailed discussion and a profit-risk analysis is provided in the individual chapters of the magazine.

  7. Parkinson's disease and osteoporosis.

    Science.gov (United States)

    Vaserman, Nathalie

    2005-12-01

    Parkinson's disease is associated with an increased risk of falls. The risk is greatest in patients with advanced disease. Because Parkinson's disease usually occurs late in life, the risk factors related to the neurological impairments add to those associated with aging. The incidence of fractures is high in patients with Parkinson's disease, with femoral neck fractures in older women being particularly common. Risk factors for fractures include a low body mass index, limited exposure to sunlight, an inadequate vitamin D intake with low 25-OH vitamin D levels, and bone loss. Several studies found decreased bone mineral density values at the femoral neck and lumbar spine in patients with Parkinson's disease. Although this decrease is ascribable in part to factors unrelated with Parkinson's disease, such as older age and female gender, Parkinson's disease itself also plays a role, most notably in patients with severe neurological impairments (Hoehn and Yahr stages III and IV).

  8. [Coeliac disease and dentistry].

    Science.gov (United States)

    van Gils, T; de Boer, N K H; Bouma, G

    2015-09-01

    Coeliac disease is a chronic autoimmune enteropathy, which is caused by exposure to dietary gluten in genetically pre-disposed individuals. -Approximately 0.5-1% of the Dutch population has coeliac disease, diag-nosed at both younger and older age. Treatment consists of a strict gluten-free diet. Symptoms can be diverse, including dental and oral manifestations. These dental and oral manifestations are often seen in patients with coeliac disease, although most of them are nonspecific. This is not the case for the symmetric enamel defects described by Aine and colleagues, which are very specific for coeliac disease. Early diagnosing of coeliac disease is important to prevent complications by (vitamin) deficiencies or rare (pre) malignant forms of coeliac disease. There seems to be a role for dentists in early diagnosing of coeliac disease.

  9. Pregnancy and rheumatic diseases.

    Science.gov (United States)

    Gayed, M; Gordon, C

    2007-11-01

    Pregnancy is an issue that should be discussed with all patients with rheumatic diseases who are in the reproductive age group. Infertility is rarely due to the disease but can be associated with cyclophosphamide therapy. Most rheumatic diseases that are well controlled prior to pregnancy do not deteriorate in pregnancy, providing that the patient continues with appropriate disease-modifying therapy. Some patients with inflammatory arthritis go in to remission during pregnancy. Patients with renal involvement may be at increased risk of disease flare. This needs to be distinguished from pre-eclampsia. Intrauterine growth restriction is more likely in patients with active systemic disease, hypertension, a history of thrombosis and renal involvement. Premature delivery may need to be planned to reduce the risks of stillbirth and can be associated with a variety of neonatal complications. Post-partum flare is common in all the rheumatic diseases.

  10. Legionella (Legionnaires' Disease and Pontiac Fever): History and Disease Patterns

    Science.gov (United States)

    ... Legionnaires’ Disease Surveillance Network (ELDSNet) History and Disease Patterns Language: English (US) Español (Spanish) Recommend on ... that the same bacterium causes both diseases. Disease Patterns Illness caused by Legionella continues to be detected, ...

  11. [The Idiopathic Parkinson's disease: A metabolic disease?].

    Science.gov (United States)

    Rieu, I; Boirie, Y; Morio, B; Derost, P; Ulla, M; Marques, A; Debilly, B; Bannier, S; Durif, F

    2010-10-01

    Parkinson's disease is a neurodegenerative disorder clinically characterized by motor impairments (tremor, bradykinesia, rigidity and postural instability) associated or not with non-motor complications (cognitive disorders, dysautonomia). Most of patients loose weight during evolution of their disease. Dysregulations of hypothalamus, which is considered as the regulatory center of satiety and energy metabolism, could play a major role in this phenomenon. Deep brain stimulation of the subthalamic nucleus (NST) is an effective method to treat patients with advanced Parkinson's disease providing marked improvement of motor impairments. This chirurgical procedure also induces a rapid and strong body weight gain and sometimes obesity. This post-operative weight gain, which exceeds largely weight lost recorded in non-operated patient, could be responsible of metabolic disorders (such as diabetes) and cardiovascular diseases. This review describes body weight variations generated by Parkinson' disease and deep brain stimulation of the NST, and focuses on metabolic disorders capable to explain them. Finally, this review emphasizes on the importance of an adequate nutritional follow up care for parkinsonian patient.

  12. Advances in coeliac disease.

    Science.gov (United States)

    Lundin, Knut E A; Sollid, Ludvig M

    2014-03-01

    To summarize the recent advances in coeliac disease. Details of the polygenic nature of coeliac disease with the human leukocyte antigen (HLA) locus as the dominating genetic element have been uncovered. The existence of a large number of non-HLA coeliac disease genes, only partly shared by each individual patient, suggests the genetic heterogeneity of the disease. The critical role for HLA-DQ-restricted CD4 T cells recognizing antigenic gluten peptides is further substantiated. Involvement of CD8 T cells has received new attention. Other components of wheat than gluten, in particular the amylase trypsin inhibitors, may also play a role. The disease is becoming more prevalent. New guidelines state that coeliac disease diagnosis in children can be made on the basis of clinical signs, serology and genetics without the need of biopsy. The clinical entity 'noncoeliac gluten sensitivity' has received much attention, but diagnostic and pathophysiological definitions are still elusive. The risk for mortality and morbidity in coeliac disease is less than previously thought. Our understanding of the basic and clinical aspects of coeliac disease increases. Coeliac disease stands out as a major health problem of almost global occurrence. Case finding, distinguishing coeliac disease from other gluten-sensitive conditions, better care and balanced use of resources are the current challenges.

  13. Multiple cystic lung disease

    Directory of Open Access Journals (Sweden)

    Flavia Angélica Ferreira Francisco

    2015-12-01

    Full Text Available Multiple cystic lung disease represents a diverse group of uncommon disorders that can present a diagnostic challenge due to the increasing number of diseases associated with this presentation. High-resolution computed tomography of the chest helps to define the morphological aspects and distribution of lung cysts, as well as associated findings. The combination of appearance upon imaging and clinical features, together with extrapulmonary manifestations, when present, permits confident and accurate diagnosis of the majority of these diseases without recourse to open-lung biopsy. The main diseases in this group that are discussed in this review are lymphangioleiomyomatosis, pulmonary Langerhans cell histiocytosis and folliculin gene-associated syndrome (Birt–Hogg–Dubé; other rare causes of cystic lung disease, including cystic metastasis of sarcoma, are also discussed. Disease progression is unpredictable, and understanding of the complications of cystic lung disease and their appearance during evolution of the disease are essential for management. Correlation of disease evolution and clinical context with chest imaging findings provides important clues for defining the underlying nature of cystic lung disease, and guides diagnostic evaluation and management.

  14. Genetics of Proteasome Diseases

    Directory of Open Access Journals (Sweden)

    Aldrin V. Gomes

    2013-01-01

    Full Text Available The proteasome is a large, multiple subunit complex that is capable of degrading most intracellular proteins. Polymorphisms in proteasome subunits are associated with cardiovascular diseases, diabetes, neurological diseases, and cancer. One polymorphism in the proteasome gene PSMA6 (−8C/G is associated with three different diseases: type 2 diabetes, myocardial infarction, and coronary artery disease. One type of proteasome, the immunoproteasome, which contains inducible catalytic subunits, is adapted to generate peptides for antigen presentation. It has recently been shown that mutations and polymorphisms in the immunoproteasome catalytic subunit PSMB8 are associated with several inflammatory and autoinflammatory diseases including Nakajo-Nishimura syndrome, CANDLE syndrome, and intestinal M. tuberculosis infection. This comprehensive review describes the disease-related polymorphisms in proteasome genes associated with human diseases and the physiological modulation of proteasome function by these polymorphisms. Given the large number of subunits and the central importance of the proteasome in human physiology as well as the fast pace of detection of proteasome polymorphisms associated with human diseases, it is likely that other polymorphisms in proteasome genes associated with diseases will be detected in the near future. While disease-associated polymorphisms are now readily discovered, the challenge will be to use this genetic information for clinical benefit.

  15. Coeliac disease and epilepsy.

    LENUS (Irish Health Repository)

    Cronin, C C

    2012-02-03

    Whether there is an association between coeliac disease and epilepsy is uncertain. Recently, a syndrome of coeliac disease, occipital lobe epilepsy and cerebral calcification has been described, mostly in Italy. We measured the prevalence of coeliac disease in patients attending a seizure clinic, and investigated whether cerebral calcification occurred in patients with both coeliac disease and epilepsy. Screening for coeliac disease was by IgA endomysial antibody, measured by indirect immunofluorescence using sections of human umbilical cord. Of 177 patients screened, four patients were positive. All had small-bowel histology typical of coeliac disease. The overall frequency of coeliac disease in this mixed patient sample was 1 in 44. In a control group of 488 pregnant patients, two serum samples were positive (1 in 244). Sixteen patients with both coeliac disease and epilepsy, who had previously attended this hospital, were identified. No patient had cerebral calcification on CT scanning. Coeliac disease appears to occur with increased frequency in patients with epilepsy, and a high index of suspicion should be maintained. Cerebral calcification is not a feature of our patients with epilepsy and coeliac disease, and may be an ethnically-or geographically-restricted finding.

  16. Celiac disease and gluten-associated diseases.

    Science.gov (United States)

    Helms, Steve

    2005-09-01

    Celiac disease develops from an autoimmune response to specific dietary grains that contain gluten. Diagnosis can be made based on the classical presentation of diarrhea, fatty stools, and abdominal bloating and cramping, as well as the presence of specific serum antibodies. In addition, gluten ingestion has increasingly been found to be associated with other conditions not usually correlated with gluten intolerance. The subsequent diversity of the clinical presentation in these cases can complicate decision-making and delay treatment initiation in conditions such as ataxia, headaches, arthritis, neuropathy, type 1 diabetes mellitus, and others. This review explores the etiology and pathology of celiac disease, presents support for the relationship between gluten and other diseases, and provides effective screening and treatment protocols.

  17. Diagnosis of Pompe disease

    DEFF Research Database (Denmark)

    Vissing, John; Lukacs, Zoltan; Straub, Volker

    2013-01-01

    of the methods used in the diagnosis and differential diagnosis of late-onset Pompe disease. Muscle biopsy is commonly used as an early diagnostic tool in the evaluation of muscle disease. However, experience has shown that relying solely on visualizing a periodic acid-Schiff-positive vacuolar myopathy...... will improve patient outcomes as care standards including enzyme replacement therapy can be applied and complications can be anticipated. Increased awareness of the clinical phenotype of Pompe disease is therefore warranted to expedite diagnostic screening for this condition with blood-based enzymatic assays.......The diagnosis of Pompe disease (acid maltase deficiency, glycogen storage disease type II) in children and adults can be challenging because of the heterogeneous clinical presentation and considerable overlap of signs and symptoms found in other neuromuscular diseases. This review evaluates some...

  18. Viral Disease Networks?

    Science.gov (United States)

    Gulbahce, Natali; Yan, Han; Vidal, Marc; Barabasi, Albert-Laszlo

    2010-03-01

    Viral infections induce multiple perturbations that spread along the links of the biological networks of the host cells. Understanding the impact of these cascading perturbations requires an exhaustive knowledge of the cellular machinery as well as a systems biology approach that reveals how individual components of the cellular system function together. Here we describe an integrative method that provides a new approach to studying virus-human interactions and its correlations with diseases. Our method involves the combined utilization of protein - protein interactions, protein -- DNA interactions, metabolomics and gene - disease associations to build a ``viraldiseasome''. By solely using high-throughput data, we map well-known viral associated diseases and predict new candidate viral diseases. We use microarray data of virus-infected tissues and patient medical history data to further test the implications of the viral diseasome. We apply this method to Epstein-Barr virus and Human Papillomavirus and shed light into molecular development of viral diseases and disease pathways.

  19. Spectrum of cardiorenal disease

    Institute of Scientific and Technical Information of China (English)

    Peter A. McCullough

    2005-01-01

    @@ Cardiorenal disease The modern day,worldwide epidemics of obesity and hypertension (HTN) are central drivers of a secondary epidemic of type 2 diabetes with combined chronic kidney disease (CKD)and cardiovascular disease (CVD).1 Approximately half of those with diabetes will develop CKD.2 Conversely,half of all cases of end-stage renal disease (ESRD) are due to diabetic nephropathy.With the aging of the general population and cardiovascular care shifting towards the elderly,an understanding of why decreasing levels of renal function act as a major adverse prognostic factor after a variety of cardiac events is imperative.The heart and kidney are inextricably linked via hemodynamic and neurohumoral function (Fig.1).Considerable evidence shows that CKD accelerates atherosclerosis,myocardial disease,valvular disease,and promotes an array of cardiac arrhythmias.3

  20. Dynamics of interacting diseases

    CERN Document Server

    Sanz, Joaquín; Meloni, Sandro; Moreno, Yamir

    2014-01-01

    Current modeling of infectious diseases allows for the study of complex and realistic scenarios that go from the population to the individual level of description. Most epidemic models however assume that the spreading process takes place on a single level (be it a single population, a meta-population system or a network of contacts). The latter is in part a consequence of our still limited knowledge about the interdependency of the many mechanisms and factors involved in disease spreading. In particular, interdependent contagion phenomena can only be addressed if we go beyond the scheme one pathogen-one network. In this paper, we study a model that allows describing the spreading dynamics of two concurrent diseases and apply it to a paradigmatic case of disease-disease interaction: the interaction between AIDS and Tuberculosis. Specifically, we characterize analytically the epidemic thresholds of the two diseases for different scenarios and also compute the temporal evolution characterizing the unfolding dyn...

  1. [Physical diseases in alcoholism].

    Science.gov (United States)

    Takase, Kojiro

    2015-09-01

    Rapid excessive alcohol drinking frequently causes disturbance of consciousness due to head trauma, brain edema, hypoglycemia, hyponatremia, hepatic coma and so on, provoked by acute alcohol intoxication. Rapid differential diagnosis and management are extremely important to save a life. On the other hands, the chronic users of alcohol so called alcoholism has many kinds of physical diseases such as liver diseases (i.e., fatty liver, alcoholic hepatitis, alcoholic liver cirrhosis and miscellaneous liver disease), diabetes mellitus, injury to happen in drunkenness, pancreas disease (i.e., acute and chronic pancreatitis and deterioration of chronic pancreatitis), gastrontestinal diseases (i.e., gastroduodenal ulcer), and so on. Enough attention should be paid to above mentioned diseases, otherwise they would turn worse more with continuation and increase in quantity of the alcohol. It should be born in its mind that the excessive drinking becomes the weapon threatening life.

  2. Genetics of Parkinson disease.

    Science.gov (United States)

    Pankratz, Nathan; Foroud, Tatiana

    2007-12-01

    During the past decade five genes have been identified that are important in autosomal dominant and autosomal recessive forms of Parkinson disease. The identification of these genes has increased our understanding of the likely pathogenic mechanisms resulting in disease. However, mutations in these genes likely contribute to disease in fewer than 5% of all cases of Parkinson disease. Thus, researchers have continued to search for genes that may influence disease susceptibility. Molecular diagnostic testing is currently available for four of the genes mutated in Parkinson disease. Evidence for reduced penetrance, possible effects of haploinsufficiency, and the identification of nondisease causing polymorphisms within several of these genes has made genetic counseling challenging. Current recommendations are to limit molecular testing only to those individuals who are symptomatic. Furthermore, because treatment is unaltered by the presence or absence of mutations in these genes, restraint is recommended when considering the value of screening for mutations in a clinical setting.

  3. Update on Parkinson disease.

    Science.gov (United States)

    Siderowf, Andrew; Stern, Matthew

    2003-04-15

    This Update reviews developments in the pathophysiology and treatment of Parkinson disease during the past several years. In the area of pathophysiology, studies have addressed the contribution of environmental factors such as caffeine and pesticides. Large-scale epidemiologic studies have also expanded the role genetic factors are thought to play. Detailed studies of kindreds with familial Parkinson disease due to alpha-synuclein and parkin have catalyzed basic science investigations into the pathologic mechanisms of the disease. These studies have led to the development of a pathophysiologic model of Parkinson disease that emphasizes abnormal protein aggregation. Studies of treatment have clarified the relative roles of l-dopa and dopamine agonists in early Parkinson disease and shown the potential for surgical interventions, particularly deep-brain stimulation, to relieve the symptoms of advanced, medically refractory disease.

  4. Parkinson's disease and genetics.

    Science.gov (United States)

    Lester, Jacobo; Otero-Siliceo, Enrique

    2006-09-01

    Idiopathic Parkinson disease (IPD) is a condition of unknown cause. Several factors are believed to contribute to its onset, and many studies have been conducted in search of the possible etiology of Parkinson disease. Genetic factors have become relevant when trying to explain the onset of Parkinson disease. The studies are divided into 2 categories: epidemiological and studies that analyze twins from families with members suffering from Parkinson disease, thus looking for the responsible genetic mutations. In this article we address this controversial topic, reviewing some of the most significant studies trying to provide evidence which relates genetics to Parkinson disease. We present current epidemiological studies and the most important genetic factors related to Parkinson disease, including the latest information currently available on each issue.

  5. Castleman disease (literature review

    Directory of Open Access Journals (Sweden)

    A. L. Melikyan

    2016-01-01

    Full Text Available Castleman disease (angiofollicular hyperplasia of lymph nodes – a rare benign lymphoproliferative disease with prolonged asymptomatic course, associated with a wide variety of autoimmune and oncological diseases and the risk of non-Hodgkin’s lymphoma. The rare occurrence of this disease and a variety of clinical course did not allow for a complete and consistent research on the etiology and pathogenesis and the standard therapies development. In recent years, the number of patients with Castleman disease in the Russian Federation has increased, which requires its recognition among non-neoplastic and neoplastic lymphadenopathy. The article provides an overview about clinical and histological variants of Castleman’s disease, its pathogenesis concepts, classification and treatment.

  6. Hereditary neuromuscular diseases

    Energy Technology Data Exchange (ETDEWEB)

    Oezsarlak, O. E-mail: ozkan.ozsarlak@uza.be; Schepens, E.; Parizel, P.M.; Goethem, J.W. van; Vanhoenacker, F.; Schepper, A.M. de; Martin, J.J

    2001-12-01

    This article presents the actual classification of neuromuscular diseases based on present expansion of our knowledge and understanding due to genetic developments. It summarizes the genetic and clinical presentations of each disorder together with CT findings, which we studied in a large group of patients with neuromuscular diseases. The muscular dystrophies as the largest and most common group of hereditary muscle diseases will be highlighted by giving detailed information about the role of CT and MRI in the differential diagnosis. The radiological features of neuromuscular diseases are atrophy, hypertrophy, pseudohypertrophy and fatty infiltration of muscles on a selective basis. Although the patterns and distribution of involvement are characteristic in some of the diseases, the definition of the type of disease based on CT scan only is not always possible.

  7. Genetics Home Reference: Ollier disease

    Science.gov (United States)

    ... Information & Resources MedlinePlus (1 link) Health Topic: Bone Diseases Genetic and Rare Diseases Information Center (1 link) Ollier disease Educational Resources (5 links) Atlas of Genetics and Cytogenetics in Oncology and Haematology Disease InfoSearch: ...

  8. Disease: H00921 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available terion to establish the diagnosis. Congenital disorder; Eye disease; Hematologic disease; Skin and connective tissue disea...se; Nervous system disease TINF2 [HSA:26277] [KO:K11112] Dyskeratos

  9. Genetics Home Reference: Alzheimer disease

    Science.gov (United States)

    ... Me Understand Genetics Home Health Conditions Alzheimer disease Alzheimer disease Enable Javascript to view the expand/collapse boxes. Download PDF Open All Close All Description Alzheimer disease is a degenerative disease of the brain ...

  10. Congenital Heart Disease in Adults

    Science.gov (United States)

    ... and genetics may play a role. Why congenital heart disease resurfaces in adulthood Some adults may find that ... in following adults with congenital heart disease. Congenital heart disease and pregnancy Women with congenital heart disease who ...

  11. Illegal Drugs and Heart Disease

    Science.gov (United States)

    ... Venous Thromboembolism Aortic Aneurysm More Illegal Drugs and Heart Disease Updated:May 17,2017 Most illegal drugs can ... www.dea.gov/druginfo/factsheets.shtml Alcohol and Heart Disease Caffeine and Heart Disease Tobacco and Heart Disease ...

  12. Bladder Control and Nerve Disease

    Science.gov (United States)

    ... procedure at regular intervals, a practice called clean intermittent catheterization. Some patients cannot place their own catheters ... Weight Management Liver Disease Urologic Diseases Endocrine Diseases Diet & Nutrition Blood Diseases Diagnostic Tests La información de ...

  13. [Rheumatic diseases in pregnancy].

    Science.gov (United States)

    Märker-Hermann, E; Bauer, H; Gromnica-Ihle, E

    2008-11-01

    Rheumatic diseases can influence the reproduction, the course of pregnancy and the development of the fetus. The inflammatory rheumatic disease itself can be modulated in its activity in terms of amelioration or exacerbation of the rheumatic symptoms. The associations between rheumatic diseases and pregnancy will be illustrated with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and systemic lupus erythematosus as examples. Antirheumatic drug therapy during pregnancy and the breast feeding period has to be adapted critically.

  14. Disease Management Update

    OpenAIRE

    2007-01-01

    The rapid expansion of disease management continues. A multitude of stakeholders and marketplaces are now involved in providing cost-effective quality healthcare for individuals and populations. To help you keep up to date with the very latest developments in disease management, this section of the journal brings you information selected from the disease management and pharmacoeconomic reporting servicePharmacoeconomics & Outcomes News. The following reports are selected from the very latest ...

  15. Disease Management Update

    OpenAIRE

    2008-01-01

    The rapid expansion of disease management continues. A multitude of stakeholders and marketplaces are now involved in providing cost-effective quality healthcare for individuals and populations. To help you keep up to date with the very latest developments in disease management, this section of the journal brings you information selected from the disease management and pharmacoeconomic reporting service Pharmacoeconomics & Outcomes News. The following reports are selected from the very latest...

  16. Disease Management Update

    OpenAIRE

    2007-01-01

    The rapid expansion of disease management continues. A multitude of stakeholders and marketplaces are now involved in providing cost-effective quality healthcare for individuals and populations. To help you keep up to date with the very latest developments in disease management, this section of the journal brings you information selected from the disease management and pharmacoeconomic reporting service Pharmacoeconomics & Outcomes News. The following reports are selected from the very latest...

  17. Disease Management Update

    OpenAIRE

    2006-01-01

    The rapid expansion of disease management continues. A multitude of stakeholders and marketplaces are now involved in providing cost effective quality healthcare for individuals and populations. To help you keep up-to-date with the very latest developments in disease management, this section of the journal brings you information selected from the disease management and pharmacoeconomic reporting service Pharmacoeconomics & Outcomes News . The following reports are selected from the very lates...

  18. Disease Management Update

    OpenAIRE

    2003-01-01

    The rapid expansion of disease management continues. A multitude of stakeholders and marketplaces are now involved in providing cost-effective quality healthcare for individuals and populations. To help you keep up-to-date with the very latest developments in disease management, this section of the journal brings you information selected from the disease management and pharmacoeconomic reporting service PharmacoEconomics & Outcomes News Weekly. The following reports are selected from the very...

  19. Disease Management Update

    OpenAIRE

    2006-01-01

    The rapid expansion of disease management continues. A multitude of stakeholders and marketplaces are now involved in providing cost-effective quality healthcare for individuals and populations. To help you keep up-to-date with the very latest developments in disease management, this section of the journal brings you information selected from the disease management and pharmacoeconomic reporting service Pharmacoeconomics & Outcomes News Weekly . The following reports are selected from the ver...

  20. Wetlands and infectious diseases

    OpenAIRE

    Robert H. Zimmerman

    2001-01-01

    There is a historical association between wetlands and infectious disease that has led to the modification of wetlands to prevent disease. At the same time there has been the development of water resources projects that increase the risk of disease. The demand for more water development projects and the increased pressure to make natural wetlands economically beneficial creates the need for an ecological approach to wetland management and health assessment. The environmental and health intera...

  1. NAFLD: A multisystem disease

    OpenAIRE

    Byrne, Christopher D.; Targher, Giovanni

    2015-01-01

    Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries that is predicted to become also the most frequent indication for liver transplantation by 2030. Over the last decade, it has been shown that the clinical burden of NAFLD is not only confined to liver-related morbidity and mortality, but there is now growing evidence that NAFLD is a multisystem disease, affecting extra-hepatic organs and regulatory pathways. For example, NAFLD incr...

  2. CDC Disease Detective Camp

    Centers for Disease Control (CDC) Podcasts

    2010-08-02

    The CDC Disease Detective Camp gives rising high school juniors and seniors exposure to key aspects of the CDC, including basic epidemiology, infectious and chronic disease tracking, public health law, and outbreak investigations. The camp also helps students explore careers in public health.  Created: 8/2/2010 by Centers for Disease Control and Prevention (CDC).   Date Released: 8/2/2010.

  3. [Crohn's disease surgery].

    Science.gov (United States)

    Kala, Zdeněk; Marek, Filip; Válek, Vlastimil A; Bartušek, Daniel

    2014-01-01

    Surgery of Crohns disease is an important part of the general treatment algorithm. The role of surgery is changing with the development of conservative procedures. The recent years have seen the return to early treatment of patients with Crohns disease. Given the character of the disease and its intestinal symptoms, a specific approach to these patients is necessary, especially regarding the correct choice of surgery. The paper focuses on the luminal damage of the small and large intestine including complications of the disease. We describe the individual indications for a surgical solution, including the choice of anastomosis or multiple / repeated surgeries.

  4. History of Kawasaki disease.

    Science.gov (United States)

    Kawasaki, Tomisaku; Naoe, Shiro

    2014-04-01

    We describe a short history of Kawasaki disease. In 1967, we published a paper entitled 'Infantile acute febrile mucocutaneous lymph node syndrome with specific desquamation of the fingers and toes. Clinical observation of 50 cases'; this was the first report on what is now called Kawasaki disease. Since then, many reports on cardiology, treatment, epidemiology, pathology and etiology of Kawasaki disease have been published. Furthermore, a recent Chapel Hill Consensus Statement on Kawasaki disease in the classification of vasculitis is given, along with a figure on the relationship and classification of childhood vasculitis by autopsy material.

  5. Disease drivers of aging.

    Science.gov (United States)

    Hodes, Richard J; Sierra, Felipe; Austad, Steven N; Epel, Elissa; Neigh, Gretchen N; Erlandson, Kristine M; Schafer, Marissa J; LeBrasseur, Nathan K; Wiley, Christopher; Campisi, Judith; Sehl, Mary E; Scalia, Rosario; Eguchi, Satoru; Kasinath, Balakuntalam S; Halter, Jeffrey B; Cohen, Harvey Jay; Demark-Wahnefried, Wendy; Ahles, Tim A; Barzilai, Nir; Hurria, Arti; Hunt, Peter W

    2016-12-01

    It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging. © 2016 New York Academy of Sciences.

  6. Pregnancy and Rheumatic Disease

    Science.gov (United States)

    ... diseases vary by condition. Rheumatoid arthritis (RA) , systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) typically are modified by pregnancy. For example, RA symptoms often improve in pregnant ...

  7. [Rheumatic diseases during pregnancy].

    Science.gov (United States)

    Fischer-Betz, R

    2012-09-01

    The treatment of inflammatory rheumatic diseases, such as rheumatoid arthritis, spondylitis ankylosans and systemic lupus erythematosus, is improving continuously. This has lead to an increasing number of young patients with a wish to have children. Greater insight into the course of rheumatic diseases during pregnancy and post partum has enabled optimized support for women with rheumatic diseases wishing to have children. To ensure a favorable outcome, pregnancy should be started during a period of disease stability and should be monitored closely. A careful assessment of possible risks and the justified use of antirheumatic drugs before, during and after pregnancy are key issues for success.

  8. Emerging zoonotic viral diseases.

    Science.gov (United States)

    Wang, L-F; Crameri, G

    2014-08-01

    Zoonotic diseases are infectious diseases that are naturally transmitted from vertebrate animals to humans and vice versa. They are caused by all types of pathogenic agents, including bacteria, parasites, fungi, viruses and prions. Although they have been recognised for many centuries, their impact on public health has increased in the last few decades due to a combination of the success in reducing the spread of human infectious diseases through vaccination and effective therapies and the emergence of novel zoonotic diseases. It is being increasingly recognised that a One Health approach at the human-animal-ecosystem interface is needed for effective investigation, prevention and control of any emerging zoonotic disease. Here, the authors will review the drivers for emergence, highlight some of the high-impact emerging zoonotic diseases of the last two decades and provide examples of novel One Health approaches for disease investigation, prevention and control. Although this review focuses on emerging zoonotic viral diseases, the authors consider that the discussions presented in this paper will be equally applicable to emerging zoonotic diseases of other pathogen types.

  9. Interstitial lung disease

    Science.gov (United States)

    Diffuse parenchymal lung disease; Alveolitis; Idiopathic pulmonary pneumonitis (IPP) ... The lungs contain tiny air sacs (alveoli), which is where oxygen is absorbed. These air sacs expand with each ...

  10. Ageing and neurodegenerative diseases.

    Science.gov (United States)

    Hung, Chia-Wei; Chen, Yu-Chih; Hsieh, Wan-Ling; Chiou, Shih-Hwa; Kao, Chung-Lan

    2010-11-01

    Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of ageing appear, causing disease formation. Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economical burdens. In seeking to ameliorate ageing and age-related diseases, the search for anti-ageing drugs has been of much interest. Numerous studies have shown that the plant polyphenol, resveratrol (3,5,4'-trihydroxystilbene), extends the lifespan of several species, prevents age-related diseases, and possesses anti-inflammatory, and anti-cancer properties. The beneficial effects of resveratrol are believed to be associated with the activation of a longevity gene, SirT1. In this review, we discuss the pathogenesis of age-related neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and cerebrovascular disease. The therapeutic potential of resveratrol, diet and the roles of stem cell therapy are discussed to provide a better understanding of the ageing mystery.

  11. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Anxiety & Psychosis OHSU - Therapeutic Approaches for PD: Depression, Anxiety & ... Parkinson's Disease? Are There Disorders That Have Similar Symptoms? What Are the Common ...

  12. Lyme disease and conservation

    Science.gov (United States)

    Ginsberg, H.

    1994-01-01

    Lyme disease is a tick-borne illness that is wide-spread in North America, especially in the northeastern and northcentral United States. This disease could negatively influence efforts to conserve natural populations in two ways: (1) the disease could directly affect wild animal health; and (2) tick control efforts could adversely affect natural populations and communities. Lyme disease affects several domestic animals, but symptoms have been reported in only a few wild species. Direct effects of Lyme disease on wild animal populations have not been reported, but the disease should be considered as a possible cause in cases of unexplained population declines in endemic areas. Methods available to manage ticks and Lyme disease include human self-protection techniques, manipulation of habitats and hosts species populations, biological control, and pesticide applications. The diversity of available techniques allows selection of approaches to minimize environmental effects by (1) emphasizing personal protection techniques, (2) carefully targeting management efforts to maximize efficiency, and (3) integrating environmentally benign techniques to improve management while avoiding broad-scale environmentally destructive approaches. The environmental effects of Lyme disease depend, to a large extent, on the methods chosen to minimize human exposure to infected ticks. Conservation biologists can help design tick management programs that effectively lower the incidence of human Lyme disease while simultaneously minimizing negative effects on natural populations.

  13. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Disease: Pharmacological Management of Depression, Anxiety & Psychosis OHSU - Therapeutic Approaches for PD: Depression, Anxiety & Psychosis Out of the Park for Parkinson's: ...

  14. Epigenetics in neonatal diseases

    Institute of Scientific and Technical Information of China (English)

    XU Xue-feng; DU Li-zhong

    2010-01-01

    Objective To review the role of epigenetic regulation in neonatal diseases and better understand Barker's "fetal origins of adult disease hypothesis".Data sources The data cited in this review were mainly obtained from the articles published in Medline/PubMed between January 1953 and December 2009.Study selection Articles associated with epigenetics and neonatal diseases were selected.Results There is a wealth of epidemiological evidence that lower birth weight is strongly correlated with an increased risk of adult diseases, such as type 2 diabetes mellitus, hypertension, and cardiovascular disease. This phenomenon of fetal origins of adult disease is strongly associated with fetal insults to epigenetic modifications of genes. A potential role of epigenetic modifications in congenital disorders, transient neonatal diabetes mellitus (TNDM), intrauterine growth retardation (IUGR), and persistent pulmonary hypertension of the newborn (PPHN) have been studied.Conclusions Acknowledgment of the role of these epigenetic modifications in neonatal diseases would be conducive to better understanding the pathogenesis of these diseases, and provide new insight for improved treatment and prevention of later adult diseases.

  15. Meditation and neurodegenerative diseases

    National Research Council Canada - National Science Library

    Newberg, Andrew B; Serruya, Mijail; Wintering, Nancy; Moss, Aleezé Sattar; Reibel, Diane; Monti, Daniel A

    2014-01-01

    .... Meditation techniques present an interesting potential adjuvant treatment for patients with neurodegenerative diseases and have the advantage of being inexpensive, and easy to teach and perform...

  16. Inhaled dust and disease

    Energy Technology Data Exchange (ETDEWEB)

    Holt, P.F.

    1987-01-01

    This book discusses the following: the respiratory system; respirable dust; the fate of inhaled dust; translocation and some general effects of inhaled dust; silicosis; experimental research on silica-related disease; natural fibrous silicates; asbestos dust levels and dust sources; asbestos-related diseases - asbestosis, lung cancer, mesothelioma and other diseases, cancers at sites other than lung and pleura; experimental research relating to asbestos-related diseases; asbestos hazard - mineral types and hazardous occupations, neighbourhood and domestic hazard; silicates other than asbestos-man-made mineral fibres, mineral silicates and cement; metals; coal mine dust, industrial carbon and arsenic; natural and synthetic organic substances; dusts that provoke allergic alveolitis; tobacco smoke.

  17. Neuroinflammation in Alzheimer's disease

    DEFF Research Database (Denmark)

    Heneka, Michael T; Carson, Monica J; Khoury, Joseph El

    2015-01-01

    Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia......, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded...... therapeutic or preventive strategies for Alzheimer's disease....

  18. Pneumococcal Disease Fast Facts

    Science.gov (United States)

    ... Streptococcus pneumoniae Transmission Clinical Features Risk Factors Diagnosis & Management Prevention For Laboratorians Drug Resistance Surveillance & Reporting Global Pneumococcal Disease and Vaccine Resources ...

  19. Immunologic lung disease

    Energy Technology Data Exchange (ETDEWEB)

    Harman, E.M.

    1985-07-01

    The term immunologic lung disease comprises a broad spectrum of disease. The authors have covered a few entities in which recent studies have been particularly helpful in elucidating pathophysiology though not in uncovering the inciting cause. Common to all of these entities is the problem of finding appropriate methods of defining disease activity and response to treatment. As exemplified by the improved outlook for Goodpasture's syndrome with elucidation of its underlying immunopathology, it is likely that better understanding of the immunologic basis of sarcoid and interstitial disease may be helpful in planning more effective treatment strategies. 44 references.

  20. Parkinson's Disease Videos

    Medline Plus

    Full Text Available ... Managing Depression, Anxiety & Psychosis OHSU - Parkinson's Disease: Pharmacological Management of Depression, Anxiety & Psychosis OHSU - Therapeutic Approaches for PD: Depression, Anxiety & Psychosis Out of the ...