Lithium-bearing fluor-arfvedsonite from Hurricane Mountain, New Hampshire: A crystal-chemical study

Science.gov (United States)

Hawthorne, F.C.; Oberti, R.; Ottolini, L.; Foord, E.E.

1996-01-01

The structures of two crystals of Li-bearing fluor-arfvedsonite (1) (K0.32Na0.68)Na2(Li0.48Fe 2+2.83Mn2+0.10Zn 0.06Fe3+1.46Ti0.07) (Si7.88Al0.12)O22[Fu1.15(OH) 0.85] and (2) (K0.25Na0.75)Na2(Li0.48Fe 2+2.84Mn2+0.11Zn 0.05Fe3+1.45Ti0.07)(Si 7.89Al0.11)O22[F1.35(OH) 0.65] from a granitic pegmatite, Hurricane Mountain, New Hampshire, have been refined to R indices of 1.5(1.6)% based on 1380(1387) reflections measured with MoK?? X-radiation. The unit cell parameters are (1) a 9.838(4), b 17.991(6), c 5.315(2) A??, 103.78(3)??, V 913.7 A??3 and (2) a 9.832(3), b 17.990(7), c 5.316(3) A??, ?? 103.79(3)??, V 913.2 A??3. Site-scattering refinement shows Li to be completely ordered at the M(3) site in these crystals. The amphibole composition is intermediate between fluor-arfvedsonite and fluor-ferro-leakeite with a small component (???10%) of fluor-ferro-ferri-nybo??ite. These amphibole crystals project into miarolitic cavities in a pegmatitic phase of a riebeckite granite. The early-crystallizing amphibole is close to fluor-ferro-leakeite in composition, but becomes progressively depleted in Li and F as crystals project out into miarolitic cavities; the final amphibole to crystallize is a fibrous Li-poor riebeckite. Li plays a significant role in late-stage fractionation involving the crystallization of alkali amphibole in peralkaline granitic environments.

Alexa Fluor-labeled Fluorescent Cellulose Nanocrystals for Bioimaging Solid Cellulose in Spatially Structured Microenvironments

Energy Technology Data Exchange (ETDEWEB)

Grate, Jay W.; Mo, Kai-For; Shin, Yongsoon; Vasdekis, Andreas; Warner, Marvin G.; Kelly, Ryan T.; Orr, Galya; Hu, Dehong; Dehoff, Karl J.; Brockman, Fred J.; Wilkins, Michael J.

2015-03-18

Cellulose nanocrystal materials have been labeled with modern Alexa Fluor dyes in a process that first links the dye to a cyanuric chloride molecule. Subsequent reaction with cellulose nanocrystals provides dyed solid microcrystalline cellulose material that can be used for bioimaging and suitable for deposition in films and spatially structured microenvironments. It is demonstrated with single molecular fluorescence microscopy that these films are subject to hydrolysis by cellulose enzymes.

FLUOR DAN KESEHATAN GIGI

Directory of Open Access Journals (Sweden)

Magdarina Destri Agtini

2012-10-01

Full Text Available Most fluoride is found in the form of chemical compounds, and the availability of free fluoride ions in soils and water is varied. Laboratory research suggests that fluoride is most effective in caries prevention when a low level of fluoride is constantly maintained in the oral cavity. Fluoride controls effectively, it acts in several different ways. Fluoride is being used widely on a global scale. The estimation of  number of people throughout the world using various types of fluoride therapy and preventive measures, they are the clinical topical fluorides (20 millions, mouth-rinses (20 millions, drops/tablets (20 millions, salt fluoridation (40 millions. water fluoridation (210 millions, and fluoridated toothpaste (500 millions. The study results of water fluoridation in USA, New Zealand, Canada, and Netherlands consequently reduces about 50% caries in community. The study of fluor tablet 1 ppm/day at primary school children in Indonesia after one year study result show that fluor tablet can inhibit the caries experience 0.2 person/year, and in control group shows the increasing of caries experience 0.8 person/year, and there is no dental fluorosis found. There are some undesirable side-effects, however, that can accompany the desirable outcome of reduced caries in the community. Experience has shown that it is not possible to achieve effective fluoride­ based caries prevention without the development of some degree of dental fluorosis, a defect of enamel caused by excess fluoride disrupting the developing enamel prior to tooth eruption. This means that whatever methods are chosen to maintain the low level of fluoride in the mouth, the results will be accompanied by some degree of dental fluorosis. Dental public health administrators should be aware of the total fluoride exposure in the population before introducing any additional fluoride programme for caries prevention, and the cost-effentiveness of such programmes should be carefully

SAFETY AT FLUOR HANFORD (A) CASE STUDY - PREPARED BY THUNDERBIRD SCHOOL OF GLOBAL MANAGEMENT

Energy Technology Data Exchange (ETDEWEB)

ARNOLD LD

2009-09-25

By November of 1997, Fluor Hanford (Fluor) had been the site manager of the Hanford nuclear reservation for a year. The Hanford site had been established as part of the Manhattan Project in the 1940s that gave birth to the atomic bomb. Hanford produced two thirds of U.S. plutonium during the Cold War period. The Hanford site was half the size of Rhode Island and occupied 586 square miles in southeastern Washington State. The production of plutonium for more than 40 years left a huge legacy of chemical and radiological contamination: 80 square miles of contaminated groundwater; 2,300 tons of spent nuclear fuel stored in underwater basins; 20 tons of plutonium-laced contaminated materials; and 500 contaminated facilities. The cleanup involved a challenging combination of radioactive material handling within an infrastructure constructed in the 1940s and 1950s. The cleanup that began in 1988 was expected to take 30 years or more. Improving safety at Hanford had already proven to be a significant challenge. As the new site manager at Hanford, Fluor Hanford inherited lower- and mid-level managers and thousands of unionized employees, many of whom were second or third generation Hanford employees. These employees had seen many contractors come and go over the years. Some of the managers who had worked with the previous contractor saw Fluor's emphasis on safety as getting in the way of operations. Union-management relations were fractious. Hanford's culture was described as 'production driven-management told everyone what to do, and, if you didn't do it, there were consequences'. Worker involvement in designing and implementing safety programs was negligible. Fluor Hanford also was having trouble satisfying its client, the Department of Energy (DOE). The DOE did not see a clear path forward for performance improvements at Hanford. Clearly, major change was necessary, but how and where should it be implemented?

SAFETY AT FLUOR HANFORD (A) CASE STUDY - PREPARED BY THUNDERBIRD SCHOOL OF GLOBAL MANAGEMENT

International Nuclear Information System (INIS)

Arnold, L.D.

2009-01-01

By November of 1997, Fluor Hanford (Fluor) had been the site manager of the Hanford nuclear reservation for a year. The Hanford site had been established as part of the Manhattan Project in the 1940s that gave birth to the atomic bomb. Hanford produced two thirds of U.S. plutonium during the Cold War period. The Hanford site was half the size of Rhode Island and occupied 586 square miles in southeastern Washington State. The production of plutonium for more than 40 years left a huge legacy of chemical and radiological contamination: 80 square miles of contaminated groundwater; 2,300 tons of spent nuclear fuel stored in underwater basins; 20 tons of plutonium-laced contaminated materials; and 500 contaminated facilities. The cleanup involved a challenging combination of radioactive material handling within an infrastructure constructed in the 1940s and 1950s. The cleanup that began in 1988 was expected to take 30 years or more. Improving safety at Hanford had already proven to be a significant challenge. As the new site manager at Hanford, Fluor Hanford inherited lower- and mid-level managers and thousands of unionized employees, many of whom were second or third generation Hanford employees. These employees had seen many contractors come and go over the years. Some of the managers who had worked with the previous contractor saw Fluor's emphasis on safety as getting in the way of operations. Union-management relations were fractious. Hanford's culture was described as 'production driven-management told everyone what to do, and, if you didn't do it, there were consequences'. Worker involvement in designing and implementing safety programs was negligible. Fluor Hanford also was having trouble satisfying its client, the Department of Energy (DOE). The DOE did not see a clear path forward for performance improvements at Hanford. Clearly, major change was necessary, but how and where should it be implemented?

Volume labeling with Alexa Fluor dyes and surface functionalization of highly sensitive fluorescent silica (SiO2) nanoparticles

Science.gov (United States)

Wang, Wei; Nallathamby, Prakash D.; Foster, Carmen M.; Morrell-Falvey, Jennifer L.; Mortensen, Ninell P.; Doktycz, Mitchel J.; Gu, Baohua; Retterer, Scott T.

2013-10-01

A new synthesis approach is described that allows the direct incorporation of fluorescent labels into the volume or body of SiO2 nanoparticles. In this process, fluorescent Alexa Fluor dyes with different emission wavelengths were covalently incorporated into the SiO2 nanoparticles during their formation by the hydrolysis of tetraethoxysilane. The dye molecules were homogeneously distributed throughout the SiO2 nanoparticles. The quantum yields of the Alexa Fluor volume-labeled SiO2 nanoparticles were much higher than nanoparticles labeled using conventional organic dyes. The size of the resulting nanoparticles was controlled using microemulsion reaction media with sizes in the range of 20-100 nm and a polydispersity of cultured macrophages. Differences in particle agglomeration and cell association were clearly associated with differences in observed nanoparticle toxicity. The capacity to maintain particle fluorescence while making significant changes to surface chemistry makes these particles extremely versatile and useful for studies of particle agglomeration, uptake, and transport in environmental and biological systems.A new synthesis approach is described that allows the direct incorporation of fluorescent labels into the volume or body of SiO2 nanoparticles. In this process, fluorescent Alexa Fluor dyes with different emission wavelengths were covalently incorporated into the SiO2 nanoparticles during their formation by the hydrolysis of tetraethoxysilane. The dye molecules were homogeneously distributed throughout the SiO2 nanoparticles. The quantum yields of the Alexa Fluor volume-labeled SiO2 nanoparticles were much higher than nanoparticles labeled using conventional organic dyes. The size of the resulting nanoparticles was controlled using microemulsion reaction media with sizes in the range of 20-100 nm and a polydispersity of cultured macrophages. Differences in particle agglomeration and cell association were clearly associated with differences in

Fluorescence of Alexa fluor dye tracks protein folding.

Directory of Open Access Journals (Sweden)

Simon Lindhoud

Full Text Available Fluorescence spectroscopy is an important tool for the characterization of protein folding. Often, a protein is labeled with appropriate fluorescent donor and acceptor probes and folding-induced changes in Förster Resonance Energy Transfer (FRET are monitored. However, conformational changes of the protein potentially affect fluorescence properties of both probes, thereby profoundly complicating interpretation of FRET data. In this study, we assess the effects protein folding has on fluorescence properties of Alexa Fluor 488 (A488, which is commonly used as FRET donor. Here, A488 is covalently attached to Cys69 of apoflavodoxin from Azotobacter vinelandii. Although coupling of A488 slightly destabilizes apoflavodoxin, the three-state folding of this protein, which involves a molten globule intermediate, is unaffected. Upon folding of apoflavodoxin, fluorescence emission intensity of A488 changes significantly. To illuminate the molecular sources of this alteration, we applied steady state and time-resolved fluorescence techniques. The results obtained show that tryptophans cause folding-induced changes in quenching of Alexa dye. Compared to unfolded protein, static quenching of A488 is increased in the molten globule. Upon populating the native state both static and dynamic quenching of A488 decrease considerably. We show that fluorescence quenching of Alexa Fluor dyes is a sensitive reporter of conformational changes during protein folding.

Fluor Hanford Integrated Safety Management System Phase II Verification Vol 1 & Vol 2

Energy Technology Data Exchange (ETDEWEB)

PARSONS, J.E.

2000-07-15

The U.S. Department of Energy (DOE) is committed to conducting work efficiently and in a manner that ensures protection of the workers, public, and environment. DOE policy mandates that safety management systems be used to systematically integrate safety into management and work practices at all levels while accomplishing mission goals in an effective and efficient manner. The purpose of the Fluor Hanford (FH) Integrated Safety Management System (ISMS) verification was to determine whether FH's ISM system and processes are sufficiently implemented to accomplish the goal of ''Do work safely.'' The purpose of the DOE, Richland Operations Office (RL) verification was to determine whether RL has established processes that adequately describe RL's role in safety management and if those processes are sufficiently implemented.

Fluor Hanford Integrated Safety Management System Phase II Verification Vol 1 and Vol 2

CERN Document Server

Parsons, J E

2000-01-01

The U.S. Department of Energy (DOE) is committed to conducting work efficiently and in a manner that ensures protection of the workers, public, and environment. DOE policy mandates that safety management systems be used to systematically integrate safety into management and work practices at all levels while accomplishing mission goals in an effective and efficient manner. The purpose of the Fluor Hanford (FH) Integrated Safety Management System (ISMS) verification was to determine whether FH's ISM system and processes are sufficiently implemented to accomplish the goal of ''Do work safely.'' The purpose of the DOE, Richland Operations Office (RL) verification was to determine whether RL has established processes that adequately describe RL's role in safety management and if those processes are sufficiently implemented.

Fluor Hanford Integrated Safety Management System Phase II Verification Vol 1 and Vol 2

International Nuclear Information System (INIS)

PARSONS, J.E.

2000-01-01

The U.S. Department of Energy (DOE) is committed to conducting work efficiently and in a manner that ensures protection of the workers, public, and environment. DOE policy mandates that safety management systems be used to systematically integrate safety into management and work practices at all levels while accomplishing mission goals in an effective and efficient manner. The purpose of the Fluor Hanford (FH) Integrated Safety Management System (ISMS) verification was to determine whether FH's ISM system and processes are sufficiently implemented to accomplish the goal of ''Do work safely.'' The purpose of the DOE, Richland Operations Office (RL) verification was to determine whether RL has established processes that adequately describe RL's role in safety management and if those processes are sufficiently implemented

The effect of monofluorophosphate implant in white rat mothers towards the level of fluor in the incisors of their young babies (Rattus-rattus

Directory of Open Access Journals (Sweden)

Widjijono Widjijono

2010-06-01

Full Text Available Background: Fluoride has been widely used in the prevention of dental caries for a long time. To prevent dental caries, fluoride must be induced in low amount at high frequency. Inducing it through implantation process even make slow release of small concentration of fluoride. Purpose: The aim of this research was to analyze whether the induction of monofluorophosphate (MFP implant into the white rat mothers affects the level of fluoride in the incisors of their young babies. Method: The objects of the research were twenty white rat mothers in two days of pregnancy which then were divided into four groups (n=5. First, those mothers have been induced with implant under their back skin until their born young babies in the age of 35 days (n=5. The level of fluoride in the incisors of those young babies then is measured with Potentiometer. The obtained data were finally analyzed with One-Way ANOVA test and continued by with LSD test (p=0.05. Result: The result of this research showed that the means of the fluoride level in the incisors of those babies divided into those four groups in series were about 11956.16±201.35 ppb (K, 27328.04±234.56 ppb (P1, 37267.21±248.86 ppb (P2, and 18103.50±267.11 ppb (P3. The result of ANOVA test then showed that the induction of various MFP implant levels significantly affected the level of fluoride in the incisors of the babies. The mean differences among the treatment groups after being tested with LSD 0.05 were also significant. Conclusion: The finding confirm that the significant increasing of the optimal fluoride retention in the incisors of white rat babies can be achieved with the induction of fluoride with MFP ions implant in about 52.98 mg.Latar belakang: Pencegahan karies gigi menggunakan senyawa fluor telah banyak dilakukan dan berlangsung dalam jangka waktu lama. Pemberian fluor dalam jumlah rendah dan frekuensi tinggi merupakan pemenuhan kebutuhan pencegahan karies gigi. Pemberian dengan cara

Magnetic study of solid uranium-fluorine complexes; Contribution a l'etude magnetique de composes fluores solides de l'uranium

Energy Technology Data Exchange (ETDEWEB)

Dianoux, A J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-06-01

A study of the magnetic susceptibility of uranium V fluorine complexes and of the magnetic resonance of fluorine atoms in uranium VI fluorine complexes has made it possible to put forward a structural model for these compounds for which it is impossible, because of the lack of suitable single crystals for X-ray diffraction work, to deduce the exact position of the fluorine atoms. It is shown that it is difficult to interpret the paramagnetism of uranium fluorides, because the uranium ions are in low-symmetry sites. A theoretical study of the magnetism of the U{sup V} ion in complex fluorides of the type M{sub 3}UF{sub 8} (M = NH{sub 4}, Na, Rb, Cs) leads to an interpretation based on a trigonal deformation of the eight fluorine atom structure surrounding the uranium atom. By applying a Hamiltonian spin formalism and making a systematic use of group theory, it is possible to present the susceptibility calculations very concisely. Study of the resonance and of the relaxation of the fluorine atoms in powdered uranium VI complex fluorides suggests a structural model in the case of NaUF{sub 7}. It is shown that the shape of the magnetic resonance absorption lines is strongly affected by the presence of large anisotropic chemical shifts. In the model proposed here, six fluorine atoms are linked to the uranium, atom by strongly covalent bonds in a deformed UF{sub 6} octahedral structure; the seventh fluorine atom remains ionic. The occurrence of a rotational movement of the octahedron is confirmed by a study of the longitudinal relaxation of the fluorine atoms, the activation energy being 0.46 eV. (author) [French] L'etude de la susceptibilite magnetique de complexes fluores d'uranium V et la resonance magnetique des fluors dans des complexes fluores d'uranium VI permettent de proposer un modele structural pour ces composes, ou la diffraction des rayons X, en l'absence de monocristaux convenables, est incapable de preciser la position des atomes de fluor. Nous montrons

Evaluation of handling and reuse approaches for the waste generated from MEA-based CO2 capture with the consideration of regulations in the UAE.

Science.gov (United States)

Nurrokhmah, Laila; Mezher, Toufic; Abu-Zahra, Mohammad R M

2013-01-01

A waste slip-stream is generated from the reclaiming process of monoethanolamine (MEA) based Post-Combustion Capture (PCC). It mainly consists of MEA itself, ammonium, heat-stable salts (HSS), carbamate polymers, and water. In this study, the waste quantity and nature are characterized for Fluor's Econamine FGSM coal-fired CO2 capture base case. Waste management options, including reuse, recycling, treatment, and disposal, are investigated due to the need for a more environmentally sound handling. Regulations, economic potential, and associated costs are also evaluated. The technical, economic, and regulation assessment suggests waste reuse for NOx scrubbing. Moreover, a high thermal condition is deemed as an effective technique for waste destruction, leading to considerations of waste recycling into a coal burner or incineration. As a means of treatment, three secondary-biological processes covering Complete-Mix Activated Sludge (CMAS), oxidation ditch, and trickling filter are designed to meet the wastewater standards in the United Arab Emirates (UAE). From the economic point of view, the value of waste as a NOx scrubbing agent is 6,561,600-7,348,992 USD/year. The secondary-biological treatment cost is 0.017-0.02 USD/ton of CO2, while the cost of an on-site incinerator is 0.031 USD/ton of CO2 captured. In conclusion, secondary biological treatment is found to be the most economical option.

Magnetic study of solid uranium-fluorine complexes; Contribution a l'etude magnetique de composes fluores solides de l'uranium

Energy Technology Data Exchange (ETDEWEB)

Dianoux, A.J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-06-01

A study of the magnetic susceptibility of uranium V fluorine complexes and of the magnetic resonance of fluorine atoms in uranium VI fluorine complexes has made it possible to put forward a structural model for these compounds for which it is impossible, because of the lack of suitable single crystals for X-ray diffraction work, to deduce the exact position of the fluorine atoms. It is shown that it is difficult to interpret the paramagnetism of uranium fluorides, because the uranium ions are in low-symmetry sites. A theoretical study of the magnetism of the U{sup V} ion in complex fluorides of the type M{sub 3}UF{sub 8} (M = NH{sub 4}, Na, Rb, Cs) leads to an interpretation based on a trigonal deformation of the eight fluorine atom structure surrounding the uranium atom. By applying a Hamiltonian spin formalism and making a systematic use of group theory, it is possible to present the susceptibility calculations very concisely. Study of the resonance and of the relaxation of the fluorine atoms in powdered uranium VI complex fluorides suggests a structural model in the case of NaUF{sub 7}. It is shown that the shape of the magnetic resonance absorption lines is strongly affected by the presence of large anisotropic chemical shifts. In the model proposed here, six fluorine atoms are linked to the uranium, atom by strongly covalent bonds in a deformed UF{sub 6} octahedral structure; the seventh fluorine atom remains ionic. The occurrence of a rotational movement of the octahedron is confirmed by a study of the longitudinal relaxation of the fluorine atoms, the activation energy being 0.46 eV. (author) [French] L'etude de la susceptibilite magnetique de complexes fluores d'uranium V et la resonance magnetique des fluors dans des complexes fluores d'uranium VI permettent de proposer un modele structural pour ces composes, ou la diffraction des rayons X, en l'absence de monocristaux convenables, est incapable de preciser la position des atomes de

Thermal expansion behavior of fluor-chlorapatite crystalline solutions

Science.gov (United States)

Hovis, G.; Harlov, D.; Gottschalk, M.; Hudacek, W.; Wildermuth, S.

2009-04-01

Apatite Ca5(PO4)3(F,Cl,OH,CO3) occurs widely as an accessory mineral in many igneous and metamorphic rocks and in nature displays a wide range of F-Cl-OH-CO3 mixtures (e.g., O'Reilly and Griffin, 2000) that have been used to interpret the role of fluids, e.g. Cl, F, and OH activities, during metamorphic and igneous processes (e.g., Harlov and Förster, 2002). It is important, therefore, to understand the thermodynamic behavior of these solid solutions, including their thermal expansion properties. Fluorapatite - chlorapatite samples were synthesized at the GFZ-Potsdam (Hovis, Harlov, Hahn and Steigert, 2007) using an adaptation of the molten flux method of Cherniak (2000). Dry CaF2 and CaCl2 (0.1 mole total) were mixed with Ca3(PO4)2 (0.03 moles), placed in a Pt crucible, equilibrated for 15 hours at 1375 °C, cooled to 1220 °C at 3 °C/hour, removed from the oven and cooled in air. Crystals were separated from the flux by boiling the quenched product in water. F:Cl fractions for each sample were determined via Rietveld refinement of X-ray powder diffraction data. Chemical homogeneity was confirmed by Rietveld refinement and high-contrast back-scattered electron imaging. Room-temperature unit-cell volumes were determined at the GFZ-Potsdam through Rietveld analysis of X-ray powder diffraction data and also at Lafayette College by standard unit-cell refinement techniques (Holland and Redfern, 1997) using NBS/NIST 640a Si as an internal standard. High-temperature unit-cell dimensions were calculated from X-ray powder diffraction data collected at Cambridge University from room temperature to 1000 °C on a Bruker D8 X-ray diffractometer. NBS Si again was utilized as an internal standard; high-temperature Si peak positions were taken from Parrish (1953). Results indicate that despite the considerable size difference between fluorine and chlorine ions, reflected by substantially different unit-cell sizes at room temperature, the coefficient of thermal expansion across

Environmental Solutions, A Summary of Contributions for FY04: PNNL Contributions to Fluor Hanford

Energy Technology Data Exchange (ETDEWEB)

Fassbender, Linda L.

2005-03-08

Pacific Northwest National Laboratory managed a variety of technical and scientific efforts to support Fluor Hanford's work in cleaning up the Hanford Site. Work done for other Hanford contractors, the Waste Treatment Plant, and directly for the U.S. Department of Energy is summarized in the other booklets in this series.

Comparison of Measurements and FluorMOD Simulations for Solar Induced Chlorophyll Fluorescence and Reflectance of a Corn Crop under Nitrogen Treatments [SIF and Reflectance for Corn

Science.gov (United States)

Middleton, Elizabeth M.; Corp, Lawrence A.; Campbell, Petya K. E.

2007-01-01

The FLuorescence Explorer (FLEX) satellite concept is one of six semifinalist mission proposals selected in 2006 for pre-Phase studies by the European Space Agency (ESA). The FLEX concept proposes to measure passive solar induced chlorophyll fluorescence (SIF) of terrestrial ecosystems. A new spectral vegetation Fluorescence Model (FluorMOD) was developed to include the effects of steady state SIF on canopy reflectance. We used our laboratory and field measurements previously acquired from foliage and canopies of corn (Zea mays L.) under controlled nitrogen (N) fertilization to parameterize and evaluate FluorMOD. Our data included biophysical properties, fluorescence (F) and reflectance spectra for leaves; reflectance spectra of canopies and soil; solar irradiance; plot-level leaf area index; and canopy SIF emissions determined using the Fraunhofer Line Depth principal for the atmospheric telluric oxygen absorption features at 688 nm (O2-beta) and 760 nm (O2-alpha). FluorMOD simulations implemented in the default "look-up-table" mode did not reproduce the observed magnitudes of leaf F, canopy SIF, or canopy reflectance. However, simulations for all of these parameters agreed with observations when the default FluorMOD information was replaced with measurements, although N treatment responses were underestimated. Recommendations were provided to enhance FluorMOD's potential utility in support of SIF field experiments and studies of agriculture and ecosystems.

Ionic Liquids: Breakthrough Absorption Technology for Post-Combustion CO{sub 2} Capture

Energy Technology Data Exchange (ETDEWEB)

Maginn, Edward

2012-09-30

This is the final report for DE-FC26-07NT43091 Ionic Liquids: Breakthrough Absorption Technology for Post-Combustion CO{sub 2} Capture. A detailed summary is provided of the ionic liquid (IL) discovery process, synthesis and testing results, process / systems modeling, lab-scale operational testing, corrosion testing and commercialization possibilities. The work resulted in the discovery of a new class of ionic liquids (ILs) that efficiently react with CO{sub 2} in a 1:1 stoichiometry with no water present and no increase in viscosity. The enthalpy of reaction was tuned to optimize process economics. The IL was found to have excellent corrosion behavior with and without CO{sub 2} present. In lab-scale tests, the IL was able to effectively remove CO{sub 2} from a simulated flue gas stream, although mass transfer was slower than with aqueous monoethanolamine (MEA) due to higher viscosities. The non-volatile nature of the solvent and its high thermal stability, however, make it an intriguing option. An independent systems analysis indicates that the economics of using the best IL discovered to date (NDIL0157), are at least comparable to and potentially slightly better than - the Fluor Econamine FG PlusTM process (DOE Case 12). Further work should be directed at improving mass transfer / lowering viscosity and developing commercial synthesis routes to make these ILs at scale in an inexpensive manner. Demonstration of the process at larger scales is also warranted, as is the exploration of other process configurations that leverage the anhydrous nature of the solvent and its extremely low volatility.

[Clinical study of the effect of preventing dentine hypersensitiveness by using Fluor Protector and Green Or on the prepared vital pulp abutment teeth].

Science.gov (United States)

Qin, Jia-nan; Lu, Yu-miao; Zhou, Xiao-yan

2005-04-01

To study and evaluate the effect preventing dentine hypersensitiveness by using Fluor Protector or Green Or on the prepared vital pulp abutment teeth of PFM bridges. 118 cases, 246 prepared vital pulp abutment teeth, were randomly divided into three groups: Experimental Group A--treated with the Fluor Protector and temporary crown; Experimental Group B--treated with the Green Or and temporary crown, and Control Group--only using temporary crown. The results of desensitization in 3 groups were evaluated. F test was used for analysis (DSPV6.01). Significant differences were found between experimental Group A, B and the control group after 1 week (when cementing the PFM bridges); and also after 1 month (P0.05). The effect of preventing dental hypersensitiveness by using Fluor Protector or Green Or on the prepared vital pulp abutment teeth of PFM bridges is ideal. It is easy to use and worth being widely applied.

In situ activation of benzyl alcohols with XtalFluor-E: formation of 1,1-diarylmethanes and 1,1,1-triarylmethanes through Friedel-Crafts benzylation.

Science.gov (United States)

Desroches, Justine; Champagne, Pier Alexandre; Benhassine, Yasmine; Paquin, Jean-François

2015-02-28

The Friedel-Crafts benzylation of arenes using benzyl alcohols activated in situ with XtalFluor-E is described. A wide range of 1,1-diarylmethanes and 1,1,1-triarylmethanes were prepared under experimentally simple and mild conditions, without the need for a transition metal or a strong Lewis acid. Notably, the reactivity observed demonstrates the potential of XtalFluor-E to induce C-OH bond ionization and SN1 reactivity of benzylic alcohols.

Polyurethane/fluor-hydroxyapatite nanocomposite scaffolds for bone tissue engineering. Part I: morphological, physical, and mechanical characterization

Science.gov (United States)

Asefnejad, Azadeh; Behnamghader, Aliasghar; Khorasani, Mohammad Taghi; Farsadzadeh, Babak

2011-01-01

In this study, new nano-fluor-hydroxyapatite (nFHA)/polyurethane composite scaffolds were fabricated for potential use in bone tissue engineering. Polyester urethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and 1,4-butanediol as chain extender. Nano fluor-hydroxyapatite (nFHA) was successfully synthesized by sol-gel method. The solid–liquid phase separation and solvent sublimation methods were used for preparation of the porous composites. Mechanical properties, chemical structure, and morphological characteristics of the samples were investigated by compressive test, Fourier transform infrared, and scanning electron microscopy (SEM) techniques, respectively. The effect of nFHA powder content on porosity and pore morphology was investigated. SEM images demonstrated that the scaffolds were constituted of interconnected and homogeneously distributed pores. The pore size of the scaffolds was in the range 50–250 μm. The result obtained in this research revealed that the porosity and pore average size decreased and compressive modulus increased with nFHA percentage. Considering morphological, physical, and mechanical properties, the scaffold with a higher ratio of nFHA has suitable potential use in tissue regeneration. PMID:21289986

Dehydration and Rehydration of Carbonated Fluor- and Hydroxylapatite

Directory of Open Access Journals (Sweden)

Claude Yoder

2012-03-01

Full Text Available The recent definitive deuterium solid state NMR spectroscopic evidence for structural water in fluor- and hydroxylapatites has prompted our study of the conditions necessary for the removal and reincorporation of this important structural feature of apatites. Thermal gravimetric analysis of 20 synthetic carbonated calcium hydroxylapatite (CCaApOH samples and nine carbonated calcium fluorapatite (CCaApF samples has been used to determine the amount of structural and adsorbed water in each sample. No correlation between the weight percent and number of moles of structural water and the weight percent carbonate in CCaApOH and CCaApF has been found. In contrast, there appears to be a relationship between the amount of adsorbed water and the carbonate concentration in the fluorapatites prepared with a two hour digestion time, as well as in the hydroxylapatites prepared with one hour digestion periods, presumably due to the effect of carbonate on crystallite size. Structural water can be removed from the apatite lattice, primarily above 200 °C, but heating to over 550 °C is required for complete removal. This water can be partly reincorporated through an apparently kinetically-controlled process that is enhanced by an increase in time and/or temperature. We speculate that the incorporation of structural water occurs at the beginning of the formation of the apatite structure, approximately coincident with the incorporation of carbonate. We also speculate that water is both removed and reincorporated by proton transfers from water molecules to hydroxide ions.

FluorWPS: A Monte Carlo ray-tracing model to compute sun-induced chlorophyll fluorescence of three-dimensional canopy

Science.gov (United States)

A model to simulate radiative transfer (RT) of sun-induced chlorophyll fluorescence (SIF) of three-dimensional (3-D) canopy, FluorWPS, was proposed and evaluated. The inclusion of fluorescence excitation was implemented with the ‘weight reduction’ and ‘photon spread’ concepts based on Monte Carlo ra...

Measurement of 2-5 keV x-ray emission from laser-target interactions by using fluor-MCP and CsI-XRD detectors

International Nuclear Information System (INIS)

Lee, P.H.Y.; Tirsell, K.G.; Leipelt, G.R.; Laird, W.B.

1981-01-01

For inertial confinement fusion plasma diagnostics, x-ray diode (XRD) detectors using conventional cathodes are not sensitive enough to measure x-rays above approx. 1.5 keV. However, for laser driver fusion targets, x-rays in the range of 2 to 5 keV are important because of their mobility in the target. We have successfully used fluor-microchannel plate (MCP) detectors to obtain absolute x-ray measurements in the 2 to 5 keV range. Recent data obtained from experiments on the Shiva laser system are presented. In addition, designs for a variety of channels in the range using fluor-MCP and CsI-XRD's above 1.5 keV will be discussed

Adsorption of volatile organic compounds by polytetra-fluor ethylene

International Nuclear Information System (INIS)

Martinet, J.M.

1958-01-01

The sorption of organic vapours by microporous polytetra-fluor ethylene has been studied gravimetrically using a Mc Bain-Baker type sorption balance. The amount of sorption, the peculiarities observed on the isotherm curves, the small influence of temperature, and smallness of hysteresis suggests that mainly physical adsorption occurs when the temperature is around 25 deg. C. The values of the surface areas obtained from the adsorption isotherms using organic vapours differ greatly from those derived from N 2 adsorption measurements. This discrepancy cannot be completely attributed to differences in the structure and chemical function of the adsorbate molecules, or to the porous structure of the adsorbent. On the contrary, the surface area values obtained by sorbing high volatile freons conform with those measured by nitrogen adsorption, which seems to imply a connection between the area of sorbed monolayers and volatility of the adsorbate. (author) [fr

Fluor Daniel Hanford Inc. integrated safety management system phase 1 verification final report

International Nuclear Information System (INIS)

PARSONS, J.E.

1999-01-01

The purpose of this review is to verify the adequacy of documentation as submitted to the Approval Authority by Fluor Daniel Hanford, Inc. (FDH). This review is not only a review of the Integrated Safety Management System (ISMS) System Description documentation, but is also a review of the procedures, policies, and manuals of practice used to implement safety management in an environment of organizational restructuring. The FDH ISMS should support the Hanford Strategic Plan (DOE-RL 1996) to safely clean up and manage the site's legacy waste; deploy science and technology while incorporating the ISMS theme to ''Do work safely''; and protect human health and the environment

Efektivitas Desensitizing Agent dengan dan tanpa Fluor pada Metode in Office Bleaching terhadap Kandungan Mineral Gigi (Kajian In Vitro

Directory of Open Access Journals (Sweden)

Yulita Kristanti

2015-12-01

-office bleaching was performed is usually overcome by using desensitizing agent with or without fluor. So far, desensitizing method applied only reduces tooth sensitivity but it had not overcome demineralization problem yet. This study was aimed to determine the influence of an application process and fluoride containing desensitizing agent in tooth mineral lossEight teeth were divided into four parts. Six specimens were smoothened using agate mortar. One mg of powder was inserted into the sample holder and mounted on goniometer heads to examine mineral content before treatment using X-Ray Diffraction (XRD. Twenty-four specimens were classified into four groups. In group I, 0,1 ml desensitizing agent without fluoride (CPP-ACP was applied for 30 minutes after an in-office bleaching using 40% Hydrogen Peroxide was performed, while in group II, CPP-ACP was applied before and after an in-office bleaching was performed. In group III 0,1 ml fluoride containing desensitizing agent (CPP-ACFP was applied for 30 minutes after in-office bleaching using 40% Hydrogen Peroxide was performed, while in group IV fluoride containing desensitizing agent was applied before and after an in-office bleaching was performed. Finally, all of the specimens were measured in their after-treatment mineral contain. Mann Whitney test showed that the lowest mineral lost was detected in group IV (4500. Fluoride containing desensitizing agent applied before and after an in-office bleaching effectively reduced mineral loss.

Anisotropy of the Chemical Shift Tensor for Fluorines in UF{sub 6} : Application to the Fluorine Atom Movement Model; Anisotropie du Tenseur de Deplacement Chimique des Fluors dans UF{sub 6}: Application au Modele du Mouvement des Atomes de Fluor; Anizotropiya tenzora khimicheskogo zameshcheniya ftora v UF{sub 6}. Primenenie k modeli dvizheniya atomov ftora; Anisotropia del Tensor de Desplazamiento Quimico de los Atomos de Fluor en el UF{sub 6}: Aplicacion al Modelo del Movimiento de los Atomos de Fluor

Energy Technology Data Exchange (ETDEWEB)

Rigny, P. [Centre d' Etudes Nucleaires de Saclay (France)

1965-10-15

'uranium poly- cristallin par la resonance magnetique du fluor a ete faite par R. Blinc et coll. a 40 Mc/s. L'auteur rappelle que le spectre obtenu a basse temperature (t < -20 Degree-Sign C) peut s'analyser en une superposition de deux raies, ce qui confirme la structure trouvee par Hoard et Stroupe aux rayons X ou, l'octaedre UF{sub 6} ayant un axe long et deux axes courts, les atomes de fluor se repartissent entre deux types de sites. L'evolution du spectre avec la temperature - coalescence des deux raies - suggere l'existence d'un mouvement des atomes de fluor entre les deux types de sites. En reprenant ces experiences a 56,4 Mc/s et a 94 Mc/s, l'auteur a pu montrer l'existence d'une forte anisotropie axiale du tenseur de deplacement chimique (environ 650 ppm). La raie d'absorption obtenue dans ces conditions pour une poudre est complexe et on est conduit pour l'etudier a envisager une fonction de forme f(h), qui est la probabilite que possede un grain de poudre d'avoir une orientation qui le fait resonner pour la valeur h du champ. En l'absence de mouvement (spectre de basse temperature), la fonction de forme pour chacune des deux raies (correspondant aux deux types de sites) a la forme obtenue pour des atomes tous equivalents. On sait que les parametres des tenseurs de deplacements chimiques renseignent sur le caractere des liaisons chimiques. On est ainsi conduit, par exemple, a attribuer un important caractere ionique (I Asymptotically-Equal-To 1/2) aux liaisons de l'uranium avec les deux atomes de fluor les plus eloignes. En presence de mouvement, la fonction de forme est tres differente et depend du type de mouvement. Pour UF{sub 6}, l'etude de la forme de la raie unique (t > 20 Degree-Sign C) en presence d'anisotropie montre que les atomes de fluor d'une meme molecule s'echangent entre eux, chaque atome passant environ 5 {mu}s a 30 Degree-Sign C dans chacune des positions, avec une energie d'activation d'environ 0,5 eV. (author) [Spanish] R. Blinc y colabs. han

Study of the dissolution of three synthetic minerals: zirconolite, Y-britholite and mono-silicate fluor-apatite; Etude de la solubilite de trois mineraux synthetiques: la zirconolite, la britholite-Y et la fluorapatite monosilicatee

Energy Technology Data Exchange (ETDEWEB)

Kamel, N.E.H.; Telmoune, S.A. [Centre de Recherche Nucleaire d' Alger, Div. des Techniques Nucleaires, Alger (Algeria); Ait-Amar, H. [Unitersite des Sciences et de la Technologie Houari Boumediene, Dept. de Genie des Procedes, Alger (Algeria)

2007-11-15

In this study, we were interested in the synthesis by natural sintering of three minerals analogue of natural rocks: zirconolite, Y-britholite and mono-silicated fluor-apatite. Cerium was used as an actinide surrogate. A simple physical characterization of the materials was made by X-ray diffraction and by measuring both densities and hardnesses. A static leaching test allowed determining the cerium immobilization capacity of the minerals. The most stable mineral was mono-silicated fluor-apatite, with a maximum amount of released cerium less than 2 %. For zirconolite and Y-britholite, this amount reached 15 and 18 % of the total cerium in the minerals, respectively. For the latter compounds, the cerium content in the materials was too weak, and the chosen synthesis method gave less satisfactory physicochemical mineral properties compared to those obtained for mono-silicated fluor-apatite. (authors)

Fluor Daniel Hanford Inc. integrated safety management system phase 1 verification final report

Energy Technology Data Exchange (ETDEWEB)

PARSONS, J.E.

1999-10-28

The purpose of this review is to verify the adequacy of documentation as submitted to the Approval Authority by Fluor Daniel Hanford, Inc. (FDH). This review is not only a review of the Integrated Safety Management System (ISMS) System Description documentation, but is also a review of the procedures, policies, and manuals of practice used to implement safety management in an environment of organizational restructuring. The FDH ISMS should support the Hanford Strategic Plan (DOE-RL 1996) to safely clean up and manage the site's legacy waste; deploy science and technology while incorporating the ISMS theme to ''Do work safely''; and protect human health and the environment.

The isotope-dilution method of fluorine microestimation; Microdosage du fluor pur dilution isotopique; Mikroopredelenie ftora no metodu razbavleniya izotopov; Microvaloracion del fluor por dilucion isotopica

Energy Technology Data Exchange (ETDEWEB)

Kudahl, J N; Fremlin, J H; Hardwick, J L [Department of Physics, University of Birmingham (United Kingdom)

1962-01-15

Fluoride ions are adsorbed on glass from acid solution and, for solutions containing less than 100 ppm of fluorine, the amount adsorbed varies very regularly with concentration. A certain volume of a carrier-free solution of the unstable isotope F{sup 18} is added to each of a set of acid fluoride solutions which may be a few milligrams, or less, in size. If the solutions are applied to a defined area of glass, some of the F{sup 18} is adsorbed and this can be fixed by raising the pH when equilibrium has been reached. The radioactivity of the glass is a measure of the total amount of fluoride on the glass and can be used to draw an adsorption isotherm from which the fluorine content of an unknown solution in the set can be found. The effects of pH, and the presence of calcium and phosphate ions have been studied, and it has been shown that organic materials may be ashed safely if calcium or magnesium ions are present. The accuracy of the method is independent of the fluoride concentration down to concentrations of a fraction of a ppm. (author) [French] L'ion de fluorure d'une solution acide est adsorbe sur du verre; pour des solutions contenant moins de 100 ppm de fluor, la quantite adsorbee varie tres regulierement en fonction de la concentration. Un certain volume d'une solution, sans entraineur-, de l'isotope instable {sup 18}F est ajoute a une serie de solutions acides de fluorure; il peut s'agir de quantites de l'ordre de quelques milligrammes, ou meme moins. Si l'on applique les solutions sur une surface bien definie de verre, une partie du {sup 18}F est adsorbee; on peut la fixer en augmentant le pH des que l'equilibre a ete realise. La radioactivite du verre donne la mesure de la quantite totale de fluorure fixe sur le verre; elle peut servir a etablir l'isotherme d'adsorption, dont en peut deduire la teneur en fluor de toute solution de la serie. Les auteurs ont etudie les effets du pH et la presence d'ions de calcium et de magnesium; ils ont montre que

The occurrence of fluor-wagnerite in UHT granulites and its implications towards understanding fluid regimes in the evolution of deep crust: a case study from the Eastern Ghats Belt, India

Science.gov (United States)

Das, Kaushik; Tomioka, Naotaka; Bose, Sankar; Ando, Jun-ichi; Ohnishi, Ichiro

2017-06-01

We report the occurrence of a rare phosphate mineral, fluor-wagnerite (Mg1.91-1.94Fe0.06-0.07Ca1000 °C, 8-9 kbar) of the studied area was retrogressed after emplacement to mid-crustal level (800-850 °C, 6-6.5 kbar) as deduced from their pressure -temperature histories. Based on mineral chemical data and micro-Raman analyses, we document an unusual high Mg-F-rich chemistry of the F-wagnerite, which occur both in peak metamorphic porphyroblastic assemblages as well as in the retrograde matrix assemblage. Therefore, in absence of other common phosphates like apatite, fluor-wagnerite can act as an indicator for the presence of F-bearing fluids for rocks with high X Mg and/or fO2. The occurrence of F-rich minerals as monitors for fluid compositions has important implications for the onset of biotite dehydration melting and hence melt production in the deep crust. We propose that fluor-wagnerite can occur as an accessory mineral associated with F-rich fluids in lower-mid crustal rocks, and F in coexisting minerals should be taken into consideration when reconciling the petrogenetic grid of biotite-dehydration melting.

A novel and selective fluoride opening of aziridines by XtalFluor-E. synthesis of fluorinated diamino acid derivatives.

Science.gov (United States)

Nonn, Melinda; Kiss, Loránd; Haukka, Matti; Fustero, Santos; Fülöp, Ferenc

2015-03-06

The selective introduction of fluorine onto the skeleton of an aminocyclopentane or cyclohexane carboxylate has been developed through a novel and efficient fluoride opening of an activated aziridine ring with XtalFluor-E. The reaction proceeded through a stereoselective aziridination of the olefinic bond of a bicyclic lactam and regioselective aziridine ring opening with difluorosulfiliminium tetrafluoroborate with the neighboring group assistance of the sulfonamide moiety to yield fluorinated diamino acid derivatives. The method based on the selective aziridine opening by fluoride has been generalized to afford access to mono- or bicyclic fluorinated substances.

HUBUNGAN KADAR FLUOR AIR MINUM TERHADAP KARIES GIGI PADA ANAK SEKOLAH DASAR DI KECAMATAN LANDONO KABUPATEN KONAWE SELATAN PROVINSI SULAWESI TENGGARA

OpenAIRE

Sunubi, Erni

2013-01-01

JURNAL MASYARAKAT EPIDEMIOLOGI INDONESIA ABSTRACT The aim of the study was to discover the correlation between potable water fluor and dental caries of elementary school children in Landono district, South Konawe regency, Southeast Sulawesi province. The study was cross sectional. The number of samples was 144 six graders elementary school children aged 12 years selected by proportional stratified random sampling. The water samples were collected from water resources consumed by the ch...

Spectrographic determination of chlorine and fluorine; Dosage du chlore et du fluor par spectrographie d'emission en atmosphere inerte

Energy Technology Data Exchange (ETDEWEB)

Contamin, G [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1965-04-01

Experimental conditions have been investigated in order to obtain the highest sensitivity in spectrographic determination of chlorine and fluorine using the Fassel method of excitation in an inert atmosphere. The influence of the nature of the atmosphere, of the discharge conditions and of the matrix material has been investigated. The following results have been established: 1. chlorine determination is definitely possible: a working curve has been drawn between 10 {mu}g and 100 {mu}g, the detection limit being around 5 {mu}g; 2. fluorine determination is not satisfactory: the detection limit is still of the order of 80 {mu}g. The best operating conditions have been defined for both elements. (author) [French] Nous avons recherche quelles etaient les conditions permettant d'obtenir la meilleure sensibilite dans le dosage spectrographique du chlore et du fluor par la methode d'excitation en atmosphere inerte (methode de Fassel). Nous avons etudie l'influence de l'atmosphere gazeuse, des conditions de la decharge et du materiau de pastillage. Les points suivants ont ete etablis: 1. le dosage du chlore est possible: une courbe de dosage a ete tracee entre 10 {mu}g et 100 {mu}g et la limite de detection est de l'ordre de 5 {mu}g; 2. le dosage du fluor n'est pas satisfaisant: la limite de detection obtenue etant encore de l'ordre de 80 {mu}g. Les conditions operatoires ont ete precisees pour ces deux elements. (auteur)

Spectrographic determination of chlorine and fluorine; Dosage du chlore et du fluor par spectrographie d'emission en atmosphere inerte

Energy Technology Data Exchange (ETDEWEB)

Contamin, G. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1965-04-01

Experimental conditions have been investigated in order to obtain the highest sensitivity in spectrographic determination of chlorine and fluorine using the Fassel method of excitation in an inert atmosphere. The influence of the nature of the atmosphere, of the discharge conditions and of the matrix material has been investigated. The following results have been established: 1. chlorine determination is definitely possible: a working curve has been drawn between 10 {mu}g and 100 {mu}g, the detection limit being around 5 {mu}g; 2. fluorine determination is not satisfactory: the detection limit is still of the order of 80 {mu}g. The best operating conditions have been defined for both elements. (author) [French] Nous avons recherche quelles etaient les conditions permettant d'obtenir la meilleure sensibilite dans le dosage spectrographique du chlore et du fluor par la methode d'excitation en atmosphere inerte (methode de Fassel). Nous avons etudie l'influence de l'atmosphere gazeuse, des conditions de la decharge et du materiau de pastillage. Les points suivants ont ete etablis: 1. le dosage du chlore est possible: une courbe de dosage a ete tracee entre 10 {mu}g et 100 {mu}g et la limite de detection est de l'ordre de 5 {mu}g; 2. le dosage du fluor n'est pas satisfaisant: la limite de detection obtenue etant encore de l'ordre de 80 {mu}g. Les conditions operatoires ont ete precisees pour ces deux elements. (auteur)

Thermal and flow analysis of the Fluor Daniel, Inc., Nuclear Material Storage Facility renovation design (initial 30% effort of Title 1)

International Nuclear Information System (INIS)

Steinke, R.G.; Mueller, C.; Knight, T.D.

1998-03-01

The computational fluid dynamics code CFX4.2 was used to evaluate steady-state thermal-hydraulic conditions in the Fluor Daniel, Inc., Nuclear Material Storage Facility renovation design (initial 30% of Title 1). Thirteen facility cases were evaluated with varying temperature dependence, drywell-array heat-source magnitude and distribution, location of the inlet tower, and no-flow curtains in the drywell-array vault. Four cases of a detailed model of the inlet-tower top fixture were evaluated to show the effect of the canopy-cruciform fixture design on the air pressure and flow distributions

Use of the water-soluble fluor sodium salicylate for fluorographic detection of tritium in thin-layer chromatograms and nitrocellulose blots

International Nuclear Information System (INIS)

Lucher, L.A.; Lego, T.

1989-01-01

We have determined that sodium salicylate, a water-soluble fluor which we use routinely for fluorography with polyacrylamide gels, is also useful for fluorography with thin-layer media. Detection of 3 H-labeled material applied to thin-layer chromatography plates, or nitrocellulose membranes, can be enhanced up to 150-fold after treatment with an aqueous solution of 2 M sodium salicylate, while detection of 35 S-labeled material is enhanced only about 2-fold. We demonstrate the utility of sodium salicylate fluorography in detecting 3H-labeled palmitic acid following thin-layer chromatography and 3 H-labeled proteins following blotting to nitrocellulose

In Vitro and In Vivo Evaluation of Alexa Fluor 680-Bombesin[7–14]NH2 Peptide Conjugate, a High-Affinity Fluorescent Probe with High Selectivity for the Gastrin-Releasing Peptide Receptor

Directory of Open Access Journals (Sweden)

Lixin Ma

2007-05-01

Full Text Available Gastrin-releasing peptide (GRP receptors are overexpressed on several types of human cancer cells, including breast, prostate, small cell lung, and pancreatic cancers. Bombesin (BBN, a 14–amino acid peptide that is an analogue of human GRP, binds to GRP receptors with very high affinity and specificity. The aim of this study was to develop a new fluorescent probe based on BBN having high tumor uptake and optimal pharmacokinetics for specific targeting and optical imaging of human breast cancer tissue. In this study, solid-phase peptide synthesis was used to produce H2N-glycylglycylglycine-BBN[7–14]NH2 peptide with the following general sequence: H2N-G-G-G-Q-W-A-V-G-H-L-M-(NH2. This conjugate was purified by reversed-phase high-performance liquid chromatography and characterized by electrospray-ionization mass spectra. The fluorescent probe Alexa Fluor 680-G-G-G-BBN[7–14]NH2 conjugate was prepared by reaction of Alexa Fluor 680 succinimidyl ester to H2N-G-G-G-BBN[7–14]NH2 in dimethylformamide (DMF. In vitro competitive binding assays, using 125I-Tyr4-BBN as the radiolabeling gold standard, demonstrated an inhibitory concentration 50% value of 7.7 ± 1.4 nM in human T-47D breast cancer cells. Confocal fluorescence microscopy images of Alexa Fluor 680-G-G-G-BBN[7–14]NH2 in human T-47D breast cancer cells indicated specific uptake, internalization, and receptor blocking of the fluorescent bioprobe in vitro. In vivo investigations in SCID mice bearing xenografted T-47D breast cancer lesions demonstrated the ability of this new conjugate to specifically target tumor tissue with high selectivity and affinity.

Bi-layered zirconia/fluor-apatite bridges supported by ceramic dental implants: a prospective case series after thirty months of observation.

Science.gov (United States)

Spies, Benedikt Christopher; Witkowski, Siegbert; Butz, Frank; Vach, Kirstin; Kohal, Ralf-Joachim

2016-10-01

The aim of this study was to determine the success and survival rate of all-ceramic bi-layered implant-supported three-unit fixed dental prostheses (IS-FDPs) 3 years after implant placement. Thirteen patients (seven males, six females; age: 41-78 years) received two one-piece ceramic implants (alumina-toughened zirconia) each in the region of the premolars or the first molar and were finally restored with adhesively cemented bi-layered zirconia-based IS-FDPs (3 in the maxilla, 10 in the mandible) composed of CAD/CAM-fabricated zirconia frameworks pressed-over with fluor-apatite glass-ceramic ingots. At prosthetic delivery and the follow-ups after 1, 2 and 3 years, the restorations were evaluated using modified United States Public Health Service (USPHS) criteria. Restorations with minor veneer chippings, a small-area occlusal roughness, slightly soundable restoration margins, minimal contour deficiencies and tolerable color deviations were regarded as success. In case of more distinct defects that could, however, be repaired to a clinically acceptable level, IS-FDPs were regarded as surviving. Kaplan-Meier plots were used for the success/survival analyses. To verify an impact on subjective patients' perceptions, satisfaction was evaluated by visual analog scales (VAS). All patients were seen 3 years after implant installation. No IS-FDP had to be replaced, resulting in 100% survival after a mean observation period of 29.5 months (median: 30.7). At the 3-year follow-up, 7/13 IS-FDPs showed a veneer chipping, 13/13 an occlusal roughness and 12/13 minimal deficiencies of contour/color. Since six restorations showed a major chipping and/or a major occlusal roughness, the Kaplan-Meier success rate was 53.8%. However, patients' significantly improved perceptions of function, esthetics, sense, and speech at prosthetic delivery remained stable over time. Bi-layered zirconia/fluor-apatite IS-FDPs entirely survived the observation period but showed a high frequency of

Facile green synthesis of silver doped fluor-hydroxyapatite/β-cyclodextrin nanocomposite in the dual acting fluorine-containing ionic liquid medium for bone substitute applications

Energy Technology Data Exchange (ETDEWEB)

Jegatheeswaran, S. [Advanced Green Chemistry Lab, Department of Industrial Chemistry, School of Chemical Sciences, Alagappa University, Karaikudi-3, Tamil Nadu (India); Selvam, S. [Laser and Sensor Application Laboratory, Pusan National University, Busan 609735 (Korea, Republic of); Sri Ramkumar, V. [Deptartment of Environmental Biotechnology, School of Environmental, Sciences, Bharathidasan University, Tiruchirappalli, Tamilnadu (India); Sundrarajan, M., E-mail: sundrarajan@yahoo.com [Advanced Green Chemistry Lab, Department of Industrial Chemistry, School of Chemical Sciences, Alagappa University, Karaikudi-3, Tamil Nadu (India)

2016-05-15

Highlights: • Fluorine based ionic liquid was highly influenced the morphological structure of nanocomposites. • These composites has been motivated controlled release of silver nanoparticles for uniform antibacterial activity. • These material has given excellent antibacterial biofilm activity and favourable cytotoxical behavior on the human osteosarcoma (MG-63) cells. • These material has been highly suitable for bone substitute appliactions. - Abstract: A novel green route has approached for the synthesis of silver doped fluor-hydroxyapatite/β-cyclodextrin composite by the assistance of fluorine-based ionic liquid. The selected [BMIM]BF{sub 4} ionic liquid for this work plays a dual role as fluoride source and templating agent. It helps to improve the crystalline structures and the shape of the composites. The crystallinity, surface morphology, topographical studies of the synthesized composite were validated. The XRD results of the composite show typical Ag reflection peaks at 38.1°, 44.2° and 63.4°. The ionic liquid assisted composite displayed the hexagonal shaped HA particles, which are surrounded by spherical nano-Ag particles and these particles are uniformly dispersed in the β-cyclodextrin matrix in both horizontal and cross sections from surface morphology observations. The Ionic liquid assisted silver doped fluor-hydroxyapatite/β-cyclodextrin composite exhibited very good antibacterial activities against Escherichia coli, Salmonella typhi, Klebsiella pneumonia and Serratia liquefaciens pathogens. The antibacterial proficiencies were established using Confocal Laser Scanning Microscopic developed biofilms images and bacterial growth curve analysis. The cytotoxicity results of the ionic liquid assisted composite analyzed by cell proliferation in vitro studies using human osteosarcoma cell line (MG-63) and this study has shown excellent biocompatibility.

Facile green synthesis of silver doped fluor-hydroxyapatite/β-cyclodextrin nanocomposite in the dual acting fluorine-containing ionic liquid medium for bone substitute applications

International Nuclear Information System (INIS)

Jegatheeswaran, S.; Selvam, S.; Sri Ramkumar, V.; Sundrarajan, M.

2016-01-01

Highlights: • Fluorine based ionic liquid was highly influenced the morphological structure of nanocomposites. • These composites has been motivated controlled release of silver nanoparticles for uniform antibacterial activity. • These material has given excellent antibacterial biofilm activity and favourable cytotoxical behavior on the human osteosarcoma (MG-63) cells. • These material has been highly suitable for bone substitute appliactions. - Abstract: A novel green route has approached for the synthesis of silver doped fluor-hydroxyapatite/β-cyclodextrin composite by the assistance of fluorine-based ionic liquid. The selected [BMIM]BF_4 ionic liquid for this work plays a dual role as fluoride source and templating agent. It helps to improve the crystalline structures and the shape of the composites. The crystallinity, surface morphology, topographical studies of the synthesized composite were validated. The XRD results of the composite show typical Ag reflection peaks at 38.1°, 44.2° and 63.4°. The ionic liquid assisted composite displayed the hexagonal shaped HA particles, which are surrounded by spherical nano-Ag particles and these particles are uniformly dispersed in the β-cyclodextrin matrix in both horizontal and cross sections from surface morphology observations. The Ionic liquid assisted silver doped fluor-hydroxyapatite/β-cyclodextrin composite exhibited very good antibacterial activities against Escherichia coli, Salmonella typhi, Klebsiella pneumonia and Serratia liquefaciens pathogens. The antibacterial proficiencies were established using Confocal Laser Scanning Microscopic developed biofilms images and bacterial growth curve analysis. The cytotoxicity results of the ionic liquid assisted composite analyzed by cell proliferation in vitro studies using human osteosarcoma cell line (MG-63) and this study has shown excellent biocompatibility.

Study of the use of an electric discharge for hollow cathodes used as optical excitation sources in the spectrographic measurement of fluorine in thorium, uranium and plutonium; Etude de l'utilisation de la decharge electrique en cathode creuse comme source d'excitation optique pour le dosage spectrographique du fluor dans le thorium, l'uranium et le plutonium

Energy Technology Data Exchange (ETDEWEB)

Bufpereau, M; Crehange, G; Poublan, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

Previous works and phenomena concerned with a hollow cathode excitation are reviewed. Experiments aimed specially on the determination of the best conditions for an analysis of fluorine in oxides-metals and solutions. In that purpose, several factors have been pointed out. One started some researches about others elements that fluorine. Carrying fluorine into discharge and excitation have been more specially studied. A quantitative analysis method is given. The analysis limit is 45 ppm about but the detection limit is 5 ppm about. As a conclusion, various ways for optical excitation of fluorine are reviewed as other analytical possibilities a hollow cathode discharge offers. (authors) [French] On rappelle les travaux effectues jusqu'alors ainsi que les phenomenes mis en jeu dans l'excitation cathode creuse. Les experiences effectuees ont eu pour but essentiel la determination des conditions optima du dosage du fluor dans les oxydes, metaux et solutions. Pour cela de nombreux facteurs ont ete mis en evidence. Certaines etudes concernant d'autres elements que le fluor ont ete amorcees. Le passage du fluor dans la decharge et son excitation ont ete plus particulierement etudies. Une methode d'analyse quantitative est degagee, la limite de dosage est de l'ordre de 45 ppm, la limite de detection de 5 ppm. En conclusion, on passe en revue les differentes methodes d'excitation optique du fluor ainsi que les autres possibilites analytiques que peut offrir la cathode creuse. (auteurs)

Amine Analysis Using AlexaFluor 488 Succinimidyl Ester and Capillary Electrophoresis with Laser-Induced Fluorescence

Directory of Open Access Journals (Sweden)

Christian G. Kendall

2015-01-01

Full Text Available Fluorescent probes enable detection of otherwise nonfluorescent species via highly sensitive laser-induced fluorescence. Organic amines are predominantly nonfluorescent and are of analytical interest in agricultural and food science, biomedical applications, and biowarfare detection. Alexa Fluor 488 N-hydroxysuccinimidyl ester (AF488 NHS-ester is an amine-specific fluorescent probe. Here, we demonstrate low limit of detection of long-chain (C9 to C18 primary amines and optimize AF488 derivatization of long-chain primary amines. The reaction was found to be equally efficient in all solvents studied (dimethylsulfoxide, ethanol, and N,N-dimethylformamide. While an organic base (N,N-diisopropylethylamine is required to achieve efficient reaction between AF488 NHS-ester and organic amines with longer hydrophobic chains, high concentrations (>5 mM result in increased levels of ethylamine and propylamine in the blank. Optimal incubation times were found to be >12 hrs at room temperature. We present an initial capillary electrophoresis separation for analysis using a simple micellar electrokinetic chromatography (MEKC buffer consisting of 12 mM sodium dodecylsulfate (SDS and 5 mM carbonate, pH 10. Limits of detection using the optimized labeling conditions and these separation conditions were 5–17 nM. The method presented here represents a novel addition to the arsenal of fluorescent probes available for highly sensitive analysis of small organic molecules.

NAVIGATING A QUALITY ROUTE TO A NATIONAL SAFETY AWARD

Energy Technology Data Exchange (ETDEWEB)

PREVETTE SS

2009-05-26

Deming quality methodologies applied to safety are recognized with the National Safety Council's annual Robert W. Campbell Award. Over the last ten years, the implementation of Statistical Process Control and quality methodologies at the U.S. Department of Energy's Hanford Site have contributed to improved safety. Improvements attributed to Statistical Process Control are evidenced in Occupational Safety and Health records and documented through several articles in Quality Progress and the American Society of Safety Engineers publication, Professional Safety. Statistical trending of safety, quality, and occurrence data continues to playa key role in improving safety and quality at what has been called the world's largest environmental cleanup project. DOE's Hanford Site played a pivotal role in the nation's defense beginning in the 1940s, when it was established as part of the Manhattan Project. After more than 50 years of producing material for nuclear weapons, Hanford, which covers 586 square miles in southeastern Washington state, is now focused on three outcomes: (1) Restoring the Columbia River corridor for multiple uses; (2) Transitioning the central plateau to support long-term waste management; and (3) Putting DOE assets to work for the future. The current environmental cleanup mission faces challenges of overlapping technical, political, regulatory, environmental, and cultural interests. From Oct. 1, 1996 through Sept. 30, 2008, Fluor Hanford was a prime contractor to the Department of Energy's Richland Operations Office. In this role, Fluor Hanford managed several major cleanup activities that included dismantling former nuclear-processing facilities, cleaning up the Site's contaminated groundwater, retrieving and processing transuranic waste for shipment and disposal off-site, maintaining the Site's infrastructure, providing security and fire protection, and operating the Volpentest HAMMER Training and Education

Improving Efficiency with 3-D Imaging: Technology Essential in Removing Plutonium Processing Equipment from Plutonium Finishing Plant Gloveboxes

International Nuclear Information System (INIS)

Crow, Stephen H.; Kyle, Richard N.; Minette, Michael J.

2008-01-01

The Plutonium Finishing Plant at Hanford, Washington began operations in 1949 to process plutonium and plutonium products. Its primary mission was to produce plutonium metal, fabricate weapons parts, and stabilize reactive materials. These operations, and subsequent activities, were performed in remote production lines, consisting primarily of hundreds of gloveboxes. Over the years these gloveboxes and processes have been continuously modified. The plant is currently inactive and Fluor Hanford has been tasked to clean out contaminated equipment and gloveboxes from the facility so it can be demolished in the near future. Approximately 100 gloveboxes at PFP have been cleaned out in the past four years and about 90 gloveboxes remain to be cleaned out. Because specific commitment dates for this work have been established with the State of Washington and other entities, it is important to adopt work practices that increase the safety and speed of this effort. The most recent work practice to be adopted by Fluor Hanford D and D workers is the use of 3-D models to improve the efficiency of cleaning out radioactive gloveboxes at the plant. The use of 3-D models has significantly improved the work planning process by providing workers with a clear image of glovebox construction and composition, which is then used to determine cleanout methods and work sequences. The 3-D visual products enhance safety by enabling workers to more easily identify hazards and implement controls. In addition, the ability to identify and target the removal of radiological materials early in the D and D process provides substantial dose reduction for the workers

Fluor Daniel Hanford implementation plan for DOE Order 5480.28. Natural phenomena hazards mitigation

International Nuclear Information System (INIS)

Conrads, T.J.

1997-01-01

Natural phenomena hazards (NPH) are unexpected acts of nature that pose a threat or danger to workers, the public, or the environment. Earthquakes, extreme winds (hurricane and tornado), snow, flooding, volcanic ashfall, and lightning strikes are examples of NPH that could occur at the Hanford Site. U.S. Department of Energy (DOE) policy requires facilities to be designed, constructed, and operated in a manner that protects workers, the public, and the environment from hazards caused by natural phenomena. DOE Order 5480.28, Natural Phenomena Hazards Mitigation, includes rigorous new natural phenomena criteria for the design of new DOE facilities, as well as for the evaluation and, if necessary, upgrade of existing DOE facilities. The Order was transmitted to Westinghouse Hanford Company in 1993 for compliance and is also identified in the Project Hanford Management Contract, Section J, Appendix C. Criteria and requirements of DOE Order 5480.28 are included in five standards, the last of which, DOE-STD-1023, was released in fiscal year 1996. Because the Order was released before all of its required standards were released, enforcement of the Order was waived pending release of the last standard and determination of an in-force date by DOE Richland Operations Office (DOE-RL). Agreement also was reached between the Management and Operations Contractor and DOE-RL that the Order would become enforceable for new structures, systems, and components (SSCS) 60 days following issue of a new order-based design criteria in HNF-PRO-97, Engineering Design and Evaluation. The order also requires that commitments addressing existing SSCs be included in an implementation plan that is to be issued 1 year following the release of the last standard. Subsequently, WHC-SP-1175, Westinghouse Hanford Company Implementation Plan for DOE Order 5480.28, Natural Phenomena Hazards Mitigation, Rev. 0, was issued in November 1996, and this document, HNF-SP-1175, Fluor Daniel Hanford

Treatability Studies Used to Test for Exothermic Reactions of Plutonium Decontamination Chemicals

Energy Technology Data Exchange (ETDEWEB)

Ewalt, John R.; Minette, Michael J.; Hopkins, Andrea M.; Cooper, Thurman D.; Simiele, Connie J.; Scott, Paul A.; Scheele, Randall D.; Charboneau, Stacy L.

2005-08-07

Fluor Hanford is decommissioning the PFP at the Hanford Site and is considering using agressive chemicals to remove transuranium contaminants. As part of the evaluation of these methods, Fluor is considering the path for disposal and the thermal stability of the waste products from the decontamination process. This paper provides the results of our studies on cerium nitrate and RadPro(TM), a nitric acid based complexant.

Technology qualification of an ambient pressure subsea cryogenic pipeline for offshore LNG loading and receiving terminals

Energy Technology Data Exchange (ETDEWEB)

Hussain, Afzal; Viteri, Martha; D' Angelo, Luis [Det Norske Veritas (DNV), Rio de Janeiro, RJ (Brazil); Prescott, Neal; Zhang, Jeff [Fluor Corporation, Irving, TX (Brazil)

2009-07-01

A project that deploys new technologies need to be confident that the technology can be implemented successfully and will perform reliably as designed. New technology is critical to industry, especially where such technology is a project enable without the existence of a backup solution, but also for projects where such technologies bring potential benefits such as technical, economic, schedule, and environmental improvements. DNV developed and has been implementing for many years a systematic, risk based technology qualification process as described in DNV RP-A203, qualification procedures for new technology. One of the major objectives of a formal technology qualification process is to ensure that risks are properly addressed. The DNV process includes several levels of technology qualification and review, starting with a statement of feasibility and concluding with a Certificate of Fitness for Service. Fluor Corporation (Fluor) has developed a new subsea cryogenic pipe-in-pipe configuration for offshore LNG loading and receiving terminals. The configuration uses a highly efficient thermal nano-porous insulation in the annular space between the inner and outer pipes. This material is kept in an ambient pressure environment, which is produced through sealing by metal bulkheads. The bulkheads transfer the contraction induced axial compression load on the inner cryogenic carrier pipe to the external jacket pipe. The resulting pipeline bundle is a structural element, which addresses the thermal contraction and expansion loads without the use of expansion bellows or ultra-low thermal contraction alloys. Fluor has followed the DNV technology qualification process to achieve the defined milestones therein which culminated in DNV issuing a certificate of fitness for service. Particular focus was put on the new aspects of the design. The certificate of fitness for service for the Fluor subsea LNG pipe technology provides project management with the confidence that this

MCO closure welding process parameter development and qualification

International Nuclear Information System (INIS)

CANNELL, G.R.

2003-01-01

One of the key elements in the SNF process is final closure of the MCO by welding. Fuel is loaded into the MCO (approximately 2 ft. in diameter and 13 ft. long) and a heavy shield plug is inserted into the top, creating a mechanical seal. The plug contains several process ports for various operations, including vacuum drying and inert-gas backfilling of the packaged fuel. When fully processed, the Canister Cover Assembly (CCA) is placed over the shield plug and final closure made by welding. The following reports the effort between the Amer Industrial Technology (AIT) and Fluor Hanford (FH) to develop and qualify the welding process for making the final closure--with primary emphasis on developing a set of robust parameters for deposition of the root pass. Work was carried out in three phases: (1) Initial welding process and equipment selection with subsequent field demonstration testing; (2) Development and qualification of a specific process technique and parameters; and (3) Validation of the process and parameters at the CSB under mock production conditions. This work establishes the process technique and parameters that provide a high level of confidence that acceptable MCO closure welds will be made on a consistent and repeatable basis

Restoring public trust while tearing down site in rural Ohio

International Nuclear Information System (INIS)

Schneider, Jerry; Wagner, Jeffrey; Connell, Judy

2007-01-01

In the mid-1980's, the impact of three decades of uranium processing near rural Fernald, Ohio, 18 miles northwest of Cincinnati, became the centre of national public controversy. When a series of incidents at the uranium foundry brought to light the years of contamination to the environment and surrounding farmland communities, local citizens' groups united and demanded a role in determining the plans for cleaning up the site. One citizens' group, Fernald Residents for Environmental Safety and Health (FRESH), formed in 1984 following reports that nearly 300 pounds of enriched uranium oxide had been released from a dust-collector system, and three off-property wells south of the site were contaminated with uranium. For 22 years, FRESH monitored activities at Fernald and participated in the decision-making process with management and regulators. The job of FRESH ended on 19 January this year when the Fernald Site was declared clean of all nuclear contamination and open to public access. It marked the end of a remarkable turnaround in public confidence and trust that had attracted critical reports from around the world. When personnel from Fluor arrived in 1992, the management team thought it understood the issues and concerns of each stakeholder group, and was determined to implement the decommissioning scope of work aggressively, confident that stakeholders would agree with its plans. This approach resulted in strained relationships with opinion leaders during the early months of Fluor's contract. To forge better relationships, the U.S. Department of Energy (DOE) who owns the site, and Fluor embarked on three new strategies based on engaging citizens and interested stakeholder groups in the decision-making process. The first strategy was opening communication channels with site leadership, technical staff, and regulators. This strategy combined a strong public-information program with two-way communications between management and the community, soliciting and

Hydroxyapatite, fluor-hydroxyapatite and fluorapatite produced via the sol-gel method: bonding to titanium and scanning electron microscopy.

Science.gov (United States)

Tredwin, Christopher J; Georgiou, George; Kim, Hae-Won; Knowles, Jonathan C

2013-05-01

Hydroxyapatite (HA), fluor-hydroxyapatite (FHA) with varying levels of fluoride ion substitution and fluorapatite (FA) production has been characterised and optimised by the sol-gel method and the dissolution and biological properties of these materials were investigated. It was the objective of this study to investigate the potential bond strength and interaction of these materials with titanium. HA, FHA and FA were synthesised by a sol-gel method. Calcium nitrate and triethyl phosphite were used as precursors under an ethanol-water based solution. Different amounts of ammonium fluoride (NH4F) were incorporated for the preparation of the FHA and FA sol-gels. Using a spin coating technique the sol-gels were coated onto commercially pure titanium disks and crystallised at various temperatures. Using scanning electron microscopy (SEM) and elemental analysis, the surface characteristics, coating thickness and interaction of the Ti substrate and coating were investigated. The bond strengths of the coating to the Ti were investigated using an Instron Universal Load Testing Machine. Statistical analysis was performed with a two-way analysis of variance and post hoc testing with a Bonferroni correction. (1) Coating speed inversely influenced the coating thickness. (2) Increasing fluoride ion substitution and heating temperature significantly increased bond strength and (3) increasing fluoride ion substitution increased the coating thickness. FHA and FA synthesised using the sol-gel technique may offer a superior alternative to coating titanium implants with HA and plasma spraying. HA, FHA and FA materials synthesised by the sol-gel method may also have a use as bone grafting materials. Copyright © 2013 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Insurance payment process for HANDI 2000 business management system

Energy Technology Data Exchange (ETDEWEB)

Wilson, D.

1998-08-24

The Pensions and Savings group handles three types of payment into and out of Fluor Daniel Hanford related to insurance benefits: Premium payment to insurance company; Application of employee insurance withholding against insurance costs; Remittance of insurance claims, and administrative fees. General approach in making and recording the remittance is by forwarding payment information to Accounts Payable Master.

Applications of Fluorine-18 in Biological Studies with Special Reference to Bone and Thyroid Physiology; Emploi du Fluor-18 dans des Études Biologiques, Notamment sur la Physiologie des Os et de la Thyroïde; ИСПОЛЬЗОВАНИЕ ФТОРА-18 В БИОЛОГИЧЕСКИХ ИССЛЕДОВАНИЯХ С УДЕЛЕНИЕМ ОСОБОГО ВНИМАНИЯ ВОПРОСАМ ФИЗИОЛОГИИ КОСТЕЙ И ФИЗИОЛОГИИ ПИТОВИДНОЙ ЖЕЛЕЗЫ; Aplicaciones del Fluor-18 en Estudios Biologicos, con Especial Referencia a la Fisiologia del Esqueleto y de la Tiroides

Energy Technology Data Exchange (ETDEWEB)

Anbar, M. [Weizmann Institute of Science (Israel); IAEC Soreq Research Establishment, Rehovot (Israel)

1963-03-15

the trapping of fluoroborate, although they diminish the overall iodine uptake. Next, it was demonstrated that the trapping stage is much less radiosensitive than the stages of thyroxine formation and release. A quite different application of F{sup 16}-labelled fluoroborate ions was in the localization of brain tumours, by directional coincidence scanning owing to the limited permeability of these ions via the intact blood- brain barrier. Fluorine-18 labelled fluoraromatic chelating agents were prepared and applied to problems in bone physiology. Fluorine-18 labelled aromatic vital dyes were used in investigating problems of permeability through biological membranes. Fluorine-18 labelled fluorine containing antimetabolites including 5-fluorouracyl and fluoro-orotic acid, have been prepared and applied to physiological problems, including cancer research. (author) [French] Dans les laboratoires de la CEAI, le fluor-18 a ete utilise au cours des trois dernieres annees pour resoudre de nombreux problemes de biologie et de medecine. Des methodes ont ete mises au point pour preparer le fluor par chacune des reactions {sup 18}O (p, n), {sup 16}O(H{sup 3}, n) et {sup 18}F(n, 2n). Des composes marques au radiofluor ont ete prepares par echange isotopique, synthese, marquage par recul et retention du fluor dans des composes fluores organiques soumis a la reaction (n, 2n). Des techniques speciales de comptage ont ete mises au point pour mesurer les faibles activites de doses traceuses de composes fluores organiques. Les ions {sup 18}F{sup -} ont ete utilises pour des etudes sur la physiologie des os. On a constate que l'ion F' est semblable au calcium en de nombreux aspects de son comportement physiologique; on a observe que la fixation F par l'os augmente sous l'influence de la vitamine D et de la testosterone tandis que la cortisone et les oestrogenes reduisent le taux de fixation. Le mode de distribution du fluor dans l'organisme se modifie lorsqu'il est administre sous la

Study of absorption and re-emission processes in a ternary liquid scintillation system

International Nuclear Information System (INIS)

Xiao Hualin; Wang Naiyan; Li Xiaobo; Cao Jun; Wen Liangjian; Zheng Dong

2010-01-01

Liquid scintillators are widely used as the neutrino target in neutrino experiments. The absorption and emission of different components of a ternary liquid scintillator (Linear Alkyl Benzene (LAB) as the solvent, 2, 5-diphenyloxazole (PPO) as the fluor and p-bis-(o-methylstyryl)-benzene (bis-MSB) as wavelength shifter) are studied. It is shown that the absorption of this liquid scintillator is dominant by LAB and PPO at wavelengths less than 349 nm, and the absorption by bis-MSB becomes prevalent at the wavelength larger than 349 nm. The fluorescence quantum yields, which are the key parameters to model the absorption and re-emission processes in large liquid scintillation detectors, are measured. (authors)

Integration of health physics, safety and operational processes for management and disposition of recycled uranium wastes at the Fernald Environmental Management Project (FEMP)

International Nuclear Information System (INIS)

Barber, James; Buckley, James

2003-01-01

Fluor Fernald, Inc. (Fluor Fernald), the contractor for the U. S. Department of Energy (DOE) Fernald Environmental Management Project (FEMP), recently submitted a new baseline plan for achieving site closure by the end of calendar year 2006. This plan was submitted at DOE's request, as the FEMP was selected as one of the sites for their accelerated closure initiative. In accordance with the accelerated baseline, the FEMP Waste Management Project (WMP) is actively evaluating innovative processes for the management and disposition of low-level uranium, fissile material, and thorium, all of which have been classified as waste. These activities are being conducted by the Low Level Waste (LLW) and Uranium Waste Disposition (UWD) projects. Alternatives associated with operational processing of individual waste streams, each of which poses potentially unique health physics, industrial hygiene and industrial hazards, are being evaluated for determination of the most cost effective and safe met hod for handling and disposition. Low-level Mixed Waste (LLMW) projects are not addressed in this paper. This paper summarizes historical uranium recycling programs and resultant trace quantity contamination of uranium waste streams with radionuclides, other than uranium. The presentation then describes how waste characterization data is reviewed for radiological and/or chemical hazards and exposure mitigation techniques, in conjunction with proposed operations for handling and disposition. The final part of the presentation consists of an overview of recent operations within LLW and UWD project dispositions, which have been safely completed, and a description of several current operations

A SAFER ROUTE TO MDI, An assessment of a phosgene free manufacturing process

NARCIS (Netherlands)

Vetter, Jeroen

2010-01-01

Supervisors: - University of Groningen Prof. dr. F. Picchioni, Drs. W.A. Prins, Prof. ir. M.W.M. Boesten, - Fluor B.V. - Haarlem Mr. G. Smit, Dr. J.C. Göebel. Abstract In this research the technological and economical feasibility of a new technology for the production of methylene diphenyl

Correlative FRET: new method improves rigor and reproducibility in determining distances within synaptic nanoscale architecture

Science.gov (United States)

Shinogle-Decker, Heather; Martinez-Rivera, Noraida; O'Brien, John; Powell, Richard D.; Joshi, Vishwas N.; Connell, Samuel; Rosa-Molinar, Eduardo

2018-02-01

A new correlative Förster Resonance Energy Transfer (FRET) microscopy method using FluoroNanogold™, a fluorescent immunoprobe with a covalently attached Nanogold® particle (1.4nm Au), overcomes resolution limitations in determining distances within synaptic nanoscale architecture. FRET by acceptor photobleaching has long been used as a method to increase fluorescence resolution. The transfer of energy from a donor to an acceptor generally occurs between 10-100Å, which is the relative distance between the donor molecule and the acceptor molecule. For the correlative FRET microscopy method using FluoroNanogold™, we immuno-labeled GFP-tagged-HeLa-expressing Connexin 35 (Cx35) with anti-GFP and with anti-Cx35/36 antibodies, and then photo-bleached the Cx before processing the sample for electron microscopic imaging. Preliminary studies reveal the use of Alexa Fluor® 594 FluoroNanogold™ slightly increases FRET distance to 70Å, in contrast to the 62.5Å using AlexaFluor 594®. Preliminary studies also show that using a FluoroNanogold™ probe inhibits photobleaching. After one photobleaching session, Alexa Fluor 594® fluorescence dropped to 19% of its original fluorescence; in contrast, after one photobleaching session, Alexa Fluor 594® FluoroNanogold™ fluorescence dropped to 53% of its original intensity. This result confirms that Alexa Fluor 594® FluoroNanogold™ is a much better donor probe than is Alexa Fluor 594®. The new method (a) creates a double confirmation method in determining structure and orientation of synaptic architecture, (b) allows development of a two-dimensional in vitro model to be used for precise testing of multiple parameters, and (c) increases throughput. Future work will include development of FluoroNanogold™ probes with different sizes of gold for additional correlative microscopy studies.

The CHPRC Columbia River Protection Project Quality Assurance Project Plan

International Nuclear Information System (INIS)

Fix, N.J.

2008-01-01

Pacific Northwest National Laboratory researchers are working on the CHPRC Columbia River Protection Project (hereafter referred to as the Columbia River Project). This is a follow-on project, funded by CH2M Hill Plateau Remediation Company, LLC (CHPRC), to the Fluor Hanford, Inc. Columbia River Protection Project. The work scope consists of a number of CHPRC funded, related projects that are managed under a master project (project number 55109). All contract releases associated with the Fluor Hanford Columbia River Project (Fluor Hanford, Inc. Contract 27647) and the CHPRC Columbia River Project (Contract 36402) will be collected under this master project. Each project within the master project is authorized by a CHPRC contract release that contains the project-specific statement of work. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by the Columbia River Project staff

The CHPRC Columbia River Protection Project Quality Assurance Project Plan

Energy Technology Data Exchange (ETDEWEB)

Fix, N. J.

2008-11-30

Pacific Northwest National Laboratory researchers are working on the CHPRC Columbia River Protection Project (hereafter referred to as the Columbia River Project). This is a follow-on project, funded by CH2M Hill Plateau Remediation Company, LLC (CHPRC), to the Fluor Hanford, Inc. Columbia River Protection Project. The work scope consists of a number of CHPRC funded, related projects that are managed under a master project (project number 55109). All contract releases associated with the Fluor Hanford Columbia River Project (Fluor Hanford, Inc. Contract 27647) and the CHPRC Columbia River Project (Contract 36402) will be collected under this master project. Each project within the master project is authorized by a CHPRC contract release that contains the project-specific statement of work. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by the Columbia River Project staff.

Antigen processing of glycoconjugate vaccines; the polysaccharide portion of the pneumococcal CRM(197) conjugate vaccine co-localizes with MHC II on the antigen processing cell surface.

Science.gov (United States)

Lai, Zengzu; Schreiber, John R

2009-05-21

Pneumococcal (Pn) polysaccharides (PS) are T-independent (TI) antigens and do not induce immunological memory or antibodies in infants. Conjugation of PnPS to the carrier protein CRM(197) induces PS-specific antibody in infants, and memory similar to T-dependent (Td) antigens. Conjugates have improved immunogenicity via antigen processing and presentation of carrier protein with MHC II and recruitment of T cell help, but the fate of the PS attached to the carrier is unknown. To determine the location of the PS component of PnPS-CRM(197) in the APC, we separately labeled PS and protein and tracked their location. The PS of types 14-CRM(197) and 19F-CRM(197) was specifically labeled by Alexa Fluor 594 hydrazide (red). The CRM(197) was separately labeled red in a reaction that did not label PS. Labeled antigens were incubated with APC which were fixed, permeabilized and incubated with anti-MHC II antibody labeled green by Alexa Fluor 488, followed by confocal microscopy. Labeled CRM(197) was presented on APC surface and co-localized with MHC II (yellow). Labeled unconjugated 14 or 19F PS did not go to the APC surface, but PS labeled 14-CRM(197) and 19F-CRM(197) was internalized and co-localized with MHC II. Monoclonal antibody to type 14 PS bound to intracellular type 14 PS and PS-CRM(197). Brefeldin A and chloroquine blocked both CRM(197) and PS labeled 14-CRM(197) and 19F-CRM(197) from co-localizing with MHC II. These data suggest that the PS component of the CRM(197) glycoconjugate enters the endosome, travels with CRM(197) peptides to the APC surface and co-localizes with MHC II.

Autofluorogram and composition and method for making the same

International Nuclear Information System (INIS)

Fost, D.L.

1980-01-01

A highly sensitive and efficient autofluorographic technique for weak radioactive emitters such as tritium or 14 C is described which involves impregnating an autofluorographic medium with a fluor in a carboxylic acid carrier. The autofluorographic effect on film of radioactive emitters contained within a medium is enhanced by contacting the medium with a fluor dissolved or dispersed in a water-soluble or water-miscible carboxylic acid to disperse the fluor throughout the medium, and precipitating the fluor. (U.K.)

Adsorption of volatile organic compounds by polytetra-fluor ethylene; Adsorption de composes organiques volatils par le polytetrafluor ethylene

Energy Technology Data Exchange (ETDEWEB)

Martinet, J.M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

The sorption of organic vapours by microporous polytetra-fluor ethylene has been studied gravimetrically using a Mc Bain-Baker type sorption balance. The amount of sorption, the peculiarities observed on the isotherm curves, the small influence of temperature, and smallness of hysteresis suggests that mainly physical adsorption occurs when the temperature is around 25 deg. C. The values of the surface areas obtained from the adsorption isotherms using organic vapours differ greatly from those derived from N{sub 2} adsorption measurements. This discrepancy cannot be completely attributed to differences in the structure and chemical function of the adsorbate molecules, or to the porous structure of the adsorbent. On the contrary, the surface area values obtained by sorbing high volatile freons conform with those measured by nitrogen adsorption, which seems to imply a connection between the area of sorbed monolayers and volatility of the adsorbate. (author) [French] La sorption de vapeurs organiques par du polytetrafluor ethylene microporeux a ete etudiee gravimetriquement a l'aide d'un appareillage du type balance de Mac Bain. La valeur de la masse adsorbee, les particularites observees dans la forme des isothermes, le peu d'influence de la temperature, la faiblesse de l'hysteresis suggerent l'intervention d'une adsorption physique, du moins au voisinage de 25 deg. C. Les isothermes relatives a l'absorption de vapeurs organiques conduisent a des valeurs de la surface specifique tres differentes de celles obtenues par adsorption d'azote. Ces divergences ne peuvent s'expliquer par la seule intervention de la structure moleculaire et de la fonction chimique de l'adsorbat, ni par la structure poreuse de l'adsorbant. Par contre, l'adsorption de freons tres volatils conduit a des valeurs de la surface specifique analogues a celles obtenues par adsorption d'azote ce qui semble etablir un lien entre la

Adsorption of volatile organic compounds by polytetra-fluor ethylene; Adsorption de composes organiques volatils par le polytetrafluor ethylene

Energy Technology Data Exchange (ETDEWEB)

Martinet, J M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1958-07-01

The sorption of organic vapours by microporous polytetra-fluor ethylene has been studied gravimetrically using a Mc Bain-Baker type sorption balance. The amount of sorption, the peculiarities observed on the isotherm curves, the small influence of temperature, and smallness of hysteresis suggests that mainly physical adsorption occurs when the temperature is around 25 deg. C. The values of the surface areas obtained from the adsorption isotherms using organic vapours differ greatly from those derived from N{sub 2} adsorption measurements. This discrepancy cannot be completely attributed to differences in the structure and chemical function of the adsorbate molecules, or to the porous structure of the adsorbent. On the contrary, the surface area values obtained by sorbing high volatile freons conform with those measured by nitrogen adsorption, which seems to imply a connection between the area of sorbed monolayers and volatility of the adsorbate. (author) [French] La sorption de vapeurs organiques par du polytetrafluor ethylene microporeux a ete etudiee gravimetriquement a l'aide d'un appareillage du type balance de Mac Bain. La valeur de la masse adsorbee, les particularites observees dans la forme des isothermes, le peu d'influence de la temperature, la faiblesse de l'hysteresis suggerent l'intervention d'une adsorption physique, du moins au voisinage de 25 deg. C. Les isothermes relatives a l'absorption de vapeurs organiques conduisent a des valeurs de la surface specifique tres differentes de celles obtenues par adsorption d'azote. Ces divergences ne peuvent s'expliquer par la seule intervention de la structure moleculaire et de la fonction chimique de l'adsorbat, ni par la structure poreuse de l'adsorbant. Par contre, l'adsorption de freons tres volatils conduit a des valeurs de la surface specifique analogues a celles obtenues par adsorption d'azote ce qui semble etablir un lien entre la volatilite de l'adsorbat et l'etendue des couches monomoleculaires

Quantitative assessment of antibody internalization with novel monoclonal antibodies against Alexa fluorophores.

Science.gov (United States)

Liao-Chan, Sindy; Daine-Matsuoka, Barbara; Heald, Nathan; Wong, Tiffany; Lin, Tracey; Cai, Allen G; Lai, Michelle; D'Alessio, Joseph A; Theunissen, Jan-Willem

2015-01-01

Antibodies against cell surface antigens may be internalized through their specific interactions with these proteins and in some cases may induce or perturb antigen internalization. The anti-cancer efficacy of antibody-drug conjugates is thought to rely on their uptake by cancer cells expressing the surface antigen. Numerous techniques, including microscopy and flow cytometry, have been used to identify antibodies with desired cellular uptake rates. To enable quantitative measurements of internalization of labeled antibodies, an assay based on internalized and quenched fluorescence was developed. For this approach, we generated novel anti-Alexa Fluor monoclonal antibodies (mAbs) that effectively and specifically quench cell surface-bound Alexa Fluor 488 or Alexa Fluor 594 fluorescence. Utilizing Alexa Fluor-labeled mAbs against the EphA2 receptor tyrosine kinase, we showed that the anti-Alexa Fluor reagents could be used to monitor internalization quantitatively over time. The anti-Alexa Fluor mAbs were also validated in a proof of concept dual-label internalization assay with simultaneous exposure of cells to two different mAbs. Importantly, the unique anti-Alexa Fluor mAbs described here may also enable other single- and dual-label experiments, including label detection and signal enhancement in macromolecules, trafficking of proteins and microorganisms, and cell migration and morphology.

Quantitative assessment of antibody internalization with novel monoclonal antibodies against Alexa fluorophores.

Directory of Open Access Journals (Sweden)

Sindy Liao-Chan

Full Text Available Antibodies against cell surface antigens may be internalized through their specific interactions with these proteins and in some cases may induce or perturb antigen internalization. The anti-cancer efficacy of antibody-drug conjugates is thought to rely on their uptake by cancer cells expressing the surface antigen. Numerous techniques, including microscopy and flow cytometry, have been used to identify antibodies with desired cellular uptake rates. To enable quantitative measurements of internalization of labeled antibodies, an assay based on internalized and quenched fluorescence was developed. For this approach, we generated novel anti-Alexa Fluor monoclonal antibodies (mAbs that effectively and specifically quench cell surface-bound Alexa Fluor 488 or Alexa Fluor 594 fluorescence. Utilizing Alexa Fluor-labeled mAbs against the EphA2 receptor tyrosine kinase, we showed that the anti-Alexa Fluor reagents could be used to monitor internalization quantitatively over time. The anti-Alexa Fluor mAbs were also validated in a proof of concept dual-label internalization assay with simultaneous exposure of cells to two different mAbs. Importantly, the unique anti-Alexa Fluor mAbs described here may also enable other single- and dual-label experiments, including label detection and signal enhancement in macromolecules, trafficking of proteins and microorganisms, and cell migration and morphology.

SAFETY STUDIES TO MEASURE EXOTHERMIC REACTIONS OF SPENT PLUTONIUM DECONTAMINATION CHEMICALS USING WET AND DRY DECONTAMINATION METHODS

International Nuclear Information System (INIS)

HOPKINS, A.M.; JACKSON, G.W.; MINETTE, M.; EWALT, J.; COOPER, T.; SCOTT, P.; JONES, S.; SCHEELEY, R.

2005-01-01

The Plutonium Finishing Plant (PFP) at the Hanford site in Eastern Washington is currently being decommissioned by Fluor Hanford. Chemicals being considered for dccontamination of gloveboxes in PFP include cerium (IV) nitrate in a nitric acid solution, and proprietary commercial solutions that include acids and sequestering agents. Aggressive chemicals are commonly used to remove transuranic contaminants from process equipment to allow disposal of the equipment as low level waste. Fluor's decontamination procedure involves application of chemical solutions as a spray on the contaminated surfaces, followed by a wipe-down with rags. Alternatively, a process of applying oxidizing Ce IV ions contained in a gel matrix and vacuuming a dry gel material is being evaluated. These processes effectively transfer the transuranic materials to rags or a gel matrix which is then packaged as TRU waste and disposed

Fernald - Developing and Executing an Accelerated Closure Plan

International Nuclear Information System (INIS)

Nixon, D.A.

2006-01-01

In November 2000 the Department of Energy (DOE) and Fluor Fernald entered into a closure contract that incited Fluor Fernald to reduce the cost and schedule of the Fernald site cleanup. The contract established a target schedule and target cost and how Fluor Fernald performs against these targets determines the amount of fee the company earns. In response to these new challenges, Fluor Fernald developed a 13-part strategy to safely accelerate work and more efficiently utilize the available funding. Implementation of this strategy required a dramatic culture change at Fernald - from a 'government job mind set' to an entrepreneurial/commercial model. Fluor Fernald's strategy and culture change has proved to be successful as the company is on track to close the site ahead of the target schedule at a total project cost less than the target cost. The elements of Fluor Fernald's strategy and the lessons learned during implementation provide valuable information that could be utilized by other DOE sites that will be undergoing closure over the next decade. (authors)

Progressively safer, cheaper demolition of Fernald

International Nuclear Information System (INIS)

Nichols, Robert; Pennington, Norman

2000-01-01

Fluor Fernald, Inc. has been progressively improving Decontamination and Dismantlement (D and D) at the Department of Energy's Fernald Environmental Management Project by applying new technologies and better methodologies to the work. Demolition issues existed in the past that necessitated new or improved solutions to maintain worker safety, protect the environment and accomplish the work in a cost effective manner. Lessons learned from D and D of 80 structures has led to a systematic approach, which can be implemented in various D and D arenas. When facility production was halted, hold-up material and process residues remained in the process piping and components. Over 500,000 pounds of material was removed by workers who completed the tasks two years ahead of schedule, $7 million under budget and with an excellent safety record. This success was the result of detailed planning and irdision of lessons learned as work progressed from facility to facility. Work sequences were developed that reduced airborne contamination. Demolition of structures has been performed at Fernald by carefully selected and qualified subcontractors. Asbestos and lead abatement, equipment, piping and conduit removal, and structural demolition have been completed to progressively higher performance specifications developed by Fluor Fernald based on lessons learned during execution. Safety continues to be the primary consideration in performing potentially hazardous work. Technologies such as hydraulic shears have been developed and used to keep workers away from danger. A new technology, ''Cool Suits,'' has been demonstrated to help prevent heat stress when anti-contamination clothing is required in elevated temperature working conditions. For tall structures, implosion technologies have been employed with progressively improved results, Several other new technologies have been evaluated by Fluor Fernald and applied by subcontractors. The improved technologies included the oxy-gas torch

Design of chemical treatment unit for radioactive liquid wastes in Serpong nuclear facilities

International Nuclear Information System (INIS)

Salimin, Z.; Walman, E.; Santoso, P.; Purnomo, S.; Sugito; Suwardiyono; Wintono

1996-01-01

The chemical treatment unit for radioactive liquid wastes arising from nuclear fuel fabrication, radioisotopes production and radiometallurgy facility has been designed. The design of chemical processing unit is based on the characteristics of liquid wastes containing fluors from uranium fluoride conversion process to ammonium uranyl carbonate on the fuel fabrication. The chemical treatment has the following process steps: coagulation-precipitation of fluoride ion by calcium hydroxide coagulant, separation of supernatant solution from sludge, coagulation of remaining fluoride on the supernatant solution by alum, separation of supernatant from sludge, and than precipitation of fluors on the supernatant by polymer resin WWS 116. The processing unit is composed of 3 storage tanks for raw liquid wastes (capacity 1 m 3 per tank), 5 storage tanks for chemicals (capacity 0.5 m 3 per tank), 2 mixing reactors (capacity 0.5 m 3 per reactor), 1 storage tank for supernatant solution (capacity 1 m 3 ), and 1 storage tank for sludge (capacity 1 m 3 )

[Recent findings in the etiopathogenesis of caries].

Science.gov (United States)

Farge, P

1998-10-01

Caries have three main interrelated etiological factors: 1) a bacteriological factor represented by cariogen oral bacteria, mainly Streptococcus mutans, which adhere to the dental surface and initiate the decalcification of the enamel by producing an acid environment through carbohydrate degradation; 2) the quality of the oral biofilm which is colonized more or less rapidly by bacteria after brushing, leading to an adhesive and aggressive dental plaque; 3) the quality of enamel which is reinforced by fluor ion, and of saliva. The early superficial phase of carie constitution is reversible through remineralisation from calcium, phosphate and fluor ions present in the oral cavity. In the absence of remineralisation the destructive and infectious process extends to the inner part of the tooth leading, to its progressive destruction. Prevention is based upon the following pathophysiological data, mainly: 1) family education on oral hygiene by regular brushing, and avoidance of foods or fluids containing sugars between meals; 2) fluoride intake starting at birth and being adapted to age, the prescription of fluoride supplementation, taking into account possible other sources of fluor (salt, water).

THE FLUORBOARD A STATISTICALLY BASED DASHBOARD METHOD FOR IMPROVING SAFETY

International Nuclear Information System (INIS)

PREVETTE, S.S.

2005-01-01

The FluorBoard is a statistically based dashboard method for improving safety. Fluor Hanford has achieved significant safety improvements--including more than a 80% reduction in OSHA cases per 200,000 hours, during its work at the US Department of Energy's Hanford Site in Washington state. The massive project on the former nuclear materials production site is considered one of the largest environmental cleanup projects in the world. Fluor Hanford's safety improvements were achieved by a committed partnering of workers, managers, and statistical methodology. Safety achievements at the site have been due to a systematic approach to safety. This includes excellent cooperation between the field workers, the safety professionals, and management through OSHA Voluntary Protection Program principles. Fluor corporate values are centered around safety, and safety excellence is important for every manager in every project. In addition, Fluor Hanford has utilized a rigorous approach to using its safety statistics, based upon Dr. Shewhart's control charts, and Dr. Deming's management and quality methods

Development of long-wavelength-emitting scintillators with improved decay time characteristics

International Nuclear Information System (INIS)

Franks, L.A.; Lutz, S.; Lyons, P.B.

1978-01-01

Progress is reported from efforts to develop radiation-to-light converters suitable for use with optical fibers as they are applied to the diagnostics of transient nuclear phenomena. Liquid and plastic fluors have been prepared which emit in the 550- to 600-nm region. Ternary liquid systems with decay times as short as 1.3 ns at 560 nm and plastic fluors with decay times less than 3 ns at 560 nm are reported. Other liquid and plastic fluors are reported with improved emission characteristics in the region of 600 nm. Conversion efficiences, on a pulse amplitude basis, are generally lower than that of a commercially available 570 nm-16 ns plastic fluor

Design Compliance Matrices to ANSI and OSHA

International Nuclear Information System (INIS)

BENDIXSEN, R.B.

2000-01-01

U.S. Department of Energy Letter 98-SFD-028 requested Fluor Daniel Hanford, Inc. to provide clarifications as to compliance with ANSI 57.1, 57.2, 57.9, and 29 CFR 1910.179 (OSHA), in the form of an item-by-item compliance matrix, for the CSB. This Supporting Document contains Fluor Daniel, Inc.'s response for use by Fluor Daniel Hanford, Inc. regarding the clarifications requested by the U.S. Department of Energy

ELECTROD FLUOR-SELECTIV

Directory of Open Access Journals (Sweden)

Mariana DÎRU

2018-03-01

Full Text Available A fost preparat un senzor anionic specific, bazat pe pivalatul trinuclear al cromului(III ca material electro­activ încorporat în membrana PVC plastifiată. Senzorul prezintă răspuns Nernstian (55,78 mV/decadă în intervalul de concentrație 10-1-10-4 mol/L cu limita de detecție 2,0∙10-5 mol/L pentru anionul fluorură. Domeniul optim de pH de funcţionare a electrodului asamblat este ˃5. Senzorul dat are un timp de răspuns de 30-60 s și reproductibilitatea rezultatelor se menține timp de 3 luni. Coeficienții potențiometrici ai selectivității au fost determinați prin metoda soluțiilor separate. A fost realizată aplicarea acestor electrozi la analiza pastei de dinți ce conține fluorură și rezultatele experimentale au fost comparate cu datele de pe prospect.FLUORIDE-SELECTIVE ELECTRODEA specific anionic sensor has been prepared, based on trinuclearchromium(III pivalate as sensing material incorpo­rated into the plasticized PVC-membrane. The sensor exhibited Nernstian response (55,78 mV/decade in the region between 10-1-10-4 mol/L with a detection limit of 2,0∙10-5 mol/L for fluoride. The working pH of the electrode was in the 5-6 range. The sensor has a response time 30-60 s and can be used for least 3 month. The potentiometric selectivity coefficients were determined by separate solution method. Application of these electrodes to the analysis of toothpaste containing fluoride has been realized and experimental results have been compared with the data on the prospectus.

Potensi “Khimelor” sebagai Tepung Komposit Tinggi Energi Tinggi Protein Berbasis Pangan Lokal (Health Potential of “Khimelor” as Composite Fluor Having Both High Energy and High Protein Level Based on Local Food

Directory of Open Access Journals (Sweden)

Laksmi Karunia Tanuwijaya

2016-07-01

The use of wheat flour as the basic ingredients of food products for high energy high protein diet is considerably high. Soybeans, mung beans, red leaf spinach and moringa leaf is local food sources of nutrients that are potential to be processed into a composite flour substituting wheat flour, which can be utilized for a variety of food products. The research was aimed to know the influence of proportion of soybeans, mung beans, red leaf spinach and moringa leaf (KhiMeLor on the quality of nutrition, protein and organoleptik quality of composite flour. This was experimental research with a complete random design. The treatment were several composition mixtures of wheat and composite flour, consisting of soybean, mung bean, red leaf spinach and moringa leaf P0 (100% : 0%; P1 (75% : 25%; P2 (50% : 50%; P3 (25% : 75%; P4 (0% : 100%. The content of carbohydrate, protein and fat was analyzed using proximate analysis. The quality of protein was examined from limiting amino acid and protein digestibility score. The sensory test was used to examine the costumer acceptance on sensory parameters. Statistical analysis used One Way Anova which  showed that substitution of  soy bean, mung bean,  moringaleaf and red spinach significantly (p=0,000 increases protein level. The limiting amino acid of P0,P1 and P2 was Lysine, but P3 and P4 was methionine. Protein digestibility of composite fluor was less than P0 (96%. The result of sensory evaluation showed that there was significant difference in aroma (p=0,000 and texture (p=0,029 which decreases as there is an increase of proportion composite flour. The conclusion was different proportion of soy bean, mung bean, moringa leaf and red spinach  influences the nutrition quality and sensory evaluation of composite flour. Keyword : composite flour, local food, KHiMelor

Metabolic Mapping of Breast Cancer with Multiphoton Spectral and Lifetime Imaging

Science.gov (United States)

2007-03-01

2002. Spectrally resolved fluorescence lifetime imaging microscopy. Appl. Spec- trosc. 56 :155-166. 38. Becker, W., A. Bergmann, E. Haustein , Z...photon fluores- cence lifetime imaging microscopy of macrophage-mediated antigen processing. J. Microsc. 185 :339-353. 45. Lin, H.J., P. Herman , and

Study of a micro-sublimation apparatus with removal of the vapours by pumping; application to the analysis of fluorinated products (1963); Etude d'un appareillage de microsublimation avec entrainement des vapeurs par pompage et application a l'analyse des produits fluores (1963)

Energy Technology Data Exchange (ETDEWEB)

Delvalle, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1963-07-01

Micro-sublimation analysis presents definite advantages both from the qualitative and quantitative points of view. An automatic micro-sublimation analysis apparatus has been developed for the analysis of fluorinated products (ClF{sub 3}, HF, UF{sub 6}, etc.) but this is only one particular application of a method which has a far wider field of possible applications. We give first the most favorable conditions for the operation of such an apparatus. These conditions are the use of a detector which is linear and independent of the nature of the gas, the flow of the sublimed vapours in the conditions of molecular flow, and finally a reproducible and linear re-heating of the separating trap. The apparatus thus built has the advantage of yielding any analysis without prior calibration. It also makes possible the easy identification of an unknown product by the determination of its vapour pressure curve and its molecular weight. The analysis of fluorinated products with this apparatus has shown that the experimental results agree well with what is expected. (author) [French] L'analyse par microsublimation presente un interet certain tant au point de vue qualitatif que quantitatif. Nous avons mis au point un appareillage automatique d'analyse par microsublimation pour l'analyse des produits fluores (CIF{sub 3}, HF, UF{sub 6}, etc.) mais il ne s'agit que de l'application a un cas particulier d'une methode ayant un champ d'applications bien plus vaste. Nous exposons tout d'abord les conditions les plus favorables au bon fonctionnement d'un tel appareil. Ces conditions sont l'emploi d'un detecteur lineaire et independant de la nature du gaz, l'ecoulement des vapeurs sublimees en regime moleculaire et enfin un rechauffage reproductible et lineaire du piege separateur. L'appareil ainsi realise presente l'avantage d'effectuer une analyse quelconque sans etalonnage prealable. Il permet en outre d'identifier aisement un corps inconnu par la determination de sa courbe de tension

Cytology of infection of apple leaves by Diplocarpon mali

Science.gov (United States)

Diplocarpon mali, the causal agent of Marssonina leaf blotch of apple, causes severe defoliation during the growing season. Little information is available on the mode of infection and infection process. In this study, the infection strategies of D. mali in apple leaves were investigated using fluor...

LEADING WITH LEADING INDICATORS

International Nuclear Information System (INIS)

PREVETTE, S.S.

2005-01-01

This paper documents Fluor Hanford's use of Leading Indicators, management leadership, and statistical methodology in order to improve safe performance of work. By applying these methods, Fluor Hanford achieved a significant reduction in injury rates in 2003 and 2004, and the improvement continues today. The integration of data, leadership, and teamwork pays off with improved safety performance and credibility with the customer. The use of Statistical Process Control, Pareto Charts, and Systems Thinking and their effect on management decisions and employee involvement are discussed. Included are practical examples of choosing leading indicators. A statistically based color coded dashboard presentation system methodology is provided. These tools, management theories and methods, coupled with involved leadership and employee efforts, directly led to significant improvements in worker safety and health, and environmental protection and restoration at one of the nation's largest nuclear cleanup sites

Results of HWVP transuranic process waste treatment laboratory and pilot-scale filtration tests using specially ground zeolite

International Nuclear Information System (INIS)

Eakin, D.E.

1996-03-01

Process waste streams from the Hanford Waste Vitrification Plant (HWVP) may require treatment for cesium, strontium, and transuranic (TRU) element removal in order to meet criteria for incorporation in grout. The approach planned for cesium and strontium removal is ion exchange using a zeolite exchanger followed by filtration. Filtration using a pneumatic hydropulse filter is planned to remove TRU elements which are associated with process solids and to also remove zeolite bearing the cesium and strontium. The solids removed during filtration are recycled to the melter feed system to be incorporated into the HWVP glass product. Fluor Daniel, Inc., the architect-engineering firm for HWVP, recommended a Pneumatic Hydropulse (PHP) filter manufactured by Mott Metallurgical Corporation for use in the HWVP. The primary waste streams considered for application of zeolite contact and filtration are melter off-gas condensate from the submerged bed scrubber (SBS), and equipment decontamination solutions from the Decontamination Waste Treatment Tank (DWTT). Other waste streams could be treated depending on TRU element and radionuclide content. Laboratory and pilot-scale filtration tests were conducted to provide a preliminary assessment of the adequacy of the recommended filter for application to HWVP waste treatment

PHYSICO-CHEMICAL CHARACTERISTICS AND QUALITY OF FEED WATERS OF THE EL-OUED CITY STUDY OF CASE (fluorine and Arsenic

Directory of Open Access Journals (Sweden)

S. E. Laouini

2015-08-01

Full Text Available In these days, of numerous country through worlds are confronted to an excess of fluor and arsenic in the wake of drink and preoccupy by in to minimize consequences on the consumers health. The arsenic and the fluor are to scale planetary polluted them of geological origin more frequently met in underground waters. In of numerous countries in expansion, waters so contaminated are often consummated without any previous treatment. Effects inorganic reserved salts in the wake of drink, benefic or luckless acting of their concentration, are known since of numerous years today already more 1,5 billion of persons have not attack to a healthy drinking-water. According to the OMS, these are 15 million to be human who die each year after to drink of the water no potable, or for want of not to have not attack to the drinking-water . Of numerous countries being in possession regions where some waters present amounts in fluor and arsenic superior to recommendations of the OMS (0,7-1,5 mg/L for fluor and 10 L/g for the arsenic. The fluor behoves against blights and hardens the teeth enamel ;to better concentration it fragilise the bone or induces points of crystallization favoring the appearance of articular distorting arthrosis : this is her fluorose. Effects ought to the arsenic are numerous: lésions of the peel, canker, illnesses cardiovasculair or pulmonarias, hypertension and cancers.This work has been realized on the water of five boreholes of the town of El-Oued in collaboration with the laboratory of the waters Algerian (ADE.The experimentation was aiming to define them plenty of fluor and arsenic exists in five boreholes to study and in fine to estimate the quality consumptive waters.

Early Life Stress and Sleep Restriction as Risk Factors in PTSD: An Integrative Pre-Clinical Approach

Science.gov (United States)

2014-04-01

month later rats were re-exposed to the context of the WAZM while their behavior was video recorded. Furthermore, c-Fos expression in the amygdala...Alexa Fluor 555 donkey α rabbit 1:1000 + Alexa Fluor 488 donkey α mouse 1:1000; both Invitrogen, Carlsbad, CA, USA) in 3% BSA + 0.3% TritonX + PBS for

Radioactive waste isolation in salt: Peer review of the Fluor Technology, Inc., report and position paper concerning waste emplacement mode and its effect on repository conceptual design

International Nuclear Information System (INIS)

Hambley, D.F.; Russell, J.E.; Whitfield, R.G.

1987-02-01

Recommendations for revising the Fluor Technology, Inc., draft position paper entitled Evaluation of Waste Emplacement Mode and the final report entitled Waste Package/Repository Impact Study include: reevaluate the relative rankings for the various emplacement modes; delete the following want objectives: maximize ability to locate the package horizon because sufficient flexibility exists to locate rooms in the relatively clean San Andres Unit 4 Salt and maximize far-field geologic integrity during retrieval because by definition the far field will be unaffected by thermal and stress perturbations caused by remining; give greater emphasis to want objectives regarding cost and use of present technology; delete the following statements from pages 1-1 and 1-2 of the draft position paper: ''No thought or study was given to the impacts of this configuration [vertical emplacement] on repository construction or short and long-term performance of the site'' and ''Subsequent salt repository designs adopted the vertical emplacement configuration as the accepted method without further evaluation.''; delete App. E and lines 8-17 of page 1-4 of the draft position paper because they are inappropriate; adopt a formal decision-analysis procedure for the 17 identified emplacement modes; revise App. F of the impact study to more accurately reflect current technology; consider designing the underground layout to take advantage of stress-relief techniques; consider eliminating reference to fuel assemblies <10 yr ''out-of-reactor''; model the temperature distribution, assuming that the repository is constructed in an infinitely large salt body; state that the results of creep analyses must be considered tentative until they can be validated by in situ measurements; and reevaluate the peak radial stresses on the waste package so that the calculated stress conditions more closely approximate expected in situ conditions

Preventive effect of ozone on the development of white spot lesions during multibracket appliance therapy.

Science.gov (United States)

Kronenberg, Otmar; Lussi, Adrian; Ruf, Sabine

2009-01-01

To test the null hypotheses: (1) there is no difference in the caries protective effect of ozone and Cervitec/Fluor Protector during multibracket (MB) appliance therapy, and (2) DIAGNOdent and quantitative light-induced fluorescence (QLF) are not superior to a visual evaluation of initial caries lesions. Twenty right-handed patients with a very poor oral hygiene who required full MB appliance therapy were analyzed during 26 months. In a split-mouth-design, the four quadrants of each patient were either treated with ozone, a combination of Cervitec and Fluor Protector, or served as untreated controls. The visible plaque index (VPI) and white spot formation were analyzed clinically. DIAGNOdent and QLF were used for a quantitative assessment of white spot formation. The average VPI in all four dental arch quadrants amounted to 55.6% and was independent of the preventive measure undertaken. In the quadrants treated with Cervitec/Fluor Protector, only 0.7% of the areas developed new, clinically visible white spots. This was significantly (P Fluor Protector during MB therapy was superior to ozone, and a visual evaluation of initial caries lesions was superior to both DIAGNOdent and QLF.

Methyl salicylate as a medium for radioassay of 36Cl using a liquid scintillation spectrometer

International Nuclear Information System (INIS)

Wiebe, L.I.; Ediss, C.

1976-01-01

Methyl salicylate (MS), a high refractive index liquid with wave-shifting properties, has been used as a Cherenkov radiation generating medium for the radioassay of 36 Cl by liquid scintillation (LS) spectrometer. Comparative experiments, using both a standard toluene-based LS fluor and toluene alone, for the measurement of 36 Cl were undertaken. The methyl salicylate medium was found to perform at an intermediate counting efficiency, near that for the LS fluor. In the presence of moderate amounts of nitromethane, the MS was less susceptible to chemical quenching effects than either the fluor or toluene. Counting efficiencies for 36 Cl in MS, toluene and toluene fluor respectively were 82.4, 28.4 and 100.3 percent with a Picker Liquimat 220 LS spectrometer, and 91.6, 54.9 and 100.0 percent with a Searle Mark III LS spectrometer. The addition of nitromethane (11.3 percent of final volume) reduced these efficiencies to 50.5, 10.0 and 15.4 percent, and to 58.8, 12.4 and 19.0 percent, respectively. The data are discussed in relation to observed changes in the pulse height spectra. Chemical quench correction by ESCR and by SCR methods is reported

IN-SITU TRITIUM BETA DETECTOR

International Nuclear Information System (INIS)

Berthold, J.W.; Jeffers, L.A.

1998-01-01

The objectives of this three-phase project were to design, develop, and demonstrate a monitoring system capable of detecting and quantifying tritium in situ in ground and surface waters, and in water from effluent lines prior to discharge into public waterways. The tritium detection system design is based on measurement of the low energy beta radiation from the radioactive decay of tritium using a special form of scintillating optical fiber directly in contact with the water to be measured. The system consists of the immersible sensor module containing the optical fiber, and an electronics package, connected by an umbilical cable. The system can be permanently installed for routine water monitoring in wells or process or effluent lines, or can be moved from one location to another for survey use. The electronics will read out tritium activity directly in units of pico Curies per liter, with straightforward calibration. In Phase 1 of the project, we characterized the sensitivity of fluor-doped plastic optical fiber to tritium beta radiation. In addition, we characterized the performance of photomultiplier tubes needed for the system. In parallel with this work, we defined the functional requirements, target specifications, and system configuration for an in situ tritium beta detector that would use the fluor-doped fibers as primary sensors of tritium concentration in water. The major conclusions from the characterization work are: A polystyrene optical fiber with fluor dopant concentration of 2% gave best performance. This fiber had the highest dopant concentration of any fibers tested. Stability may be a problem. The fibers exposed to a 22-day soak in 120 F water experienced a 10x reduction in sensitivity. It is not known whether this was due to the build up of a deposit (a potentially reversible effect) or an irreversible process such as leaching of the scintillating dye. Based on the results achieved, it is premature to initiate Phase 2 and commit to a prototype

IN-SITU TRITIUM BETA DETECTOR

Energy Technology Data Exchange (ETDEWEB)

J.W. Berthold; L.A. Jeffers

1998-04-15

The objectives of this three-phase project were to design, develop, and demonstrate a monitoring system capable of detecting and quantifying tritium in situ in ground and surface waters, and in water from effluent lines prior to discharge into public waterways. The tritium detection system design is based on measurement of the low energy beta radiation from the radioactive decay of tritium using a special form of scintillating optical fiber directly in contact with the water to be measured. The system consists of the immersible sensor module containing the optical fiber, and an electronics package, connected by an umbilical cable. The system can be permanently installed for routine water monitoring in wells or process or effluent lines, or can be moved from one location to another for survey use. The electronics will read out tritium activity directly in units of pico Curies per liter, with straightforward calibration. In Phase 1 of the project, we characterized the sensitivity of fluor-doped plastic optical fiber to tritium beta radiation. In addition, we characterized the performance of photomultiplier tubes needed for the system. In parallel with this work, we defined the functional requirements, target specifications, and system configuration for an in situ tritium beta detector that would use the fluor-doped fibers as primary sensors of tritium concentration in water. The major conclusions from the characterization work are: A polystyrene optical fiber with fluor dopant concentration of 2% gave best performance. This fiber had the highest dopant concentration of any fibers tested. Stability may be a problem. The fibers exposed to a 22-day soak in 120 F water experienced a 10x reduction in sensitivity. It is not known whether this was due to the build up of a deposit (a potentially reversible effect) or an irreversible process such as leaching of the scintillating dye. Based on the results achieved, it is premature to initiate Phase 2 and commit to a prototype

Dual Alkali Solvent System for CO2 Capture from Flue Gas.

Science.gov (United States)

Li, Yang; Wang, H Paul; Liao, Chang-Yu; Zhao, Xinglei; Hsiung, Tung-Li; Liu, Shou-Heng; Chang, Shih-Ger

2017-08-01

A novel two-aqueous-phase CO 2 capture system, namely the dual alkali solvent (DAS) system, has been developed. Unlike traditional solvent-based CO 2 capture systems in which the same solvent is used for both CO 2 absorption and stripping, the solvent of the DAS system consists of two aqueous phases. The upper phase, which contains an organic alkali 1-(2-hydroxyethyl) piperazine (HEP), is used for CO 2 absorption. The lower phase, which consists of a mixture of K 2 CO 3 /KHCO 3 aqueous solution and KHCO 3 precipitate, is used for CO 2 stripping. Only a certain kind of amine (such as HEP) is able to ensure the phase separation, satisfactory absorption efficiency, effective CO 2 transfer from the upper phase to the lower phase, and regeneration of the upper phase. In the meantime, due to the presence of K 2 CO 3 /KHCO 3 in the lower phase, HEP in the upper phase is capable of being regenerated from its sulfite/sulfate heat stable salt, which enables the simultaneous absorption of CO 2 and SO 2 /SO 3 from the flue gas. Preliminary experiments and simulations indicate that the implementation of the DAS system can lead to 24.0% stripping energy savings compared to the Econamine process, without significantly lowering the CO 2 absorption efficiency (∼90%).

Fis protein induced λF-DNA bending observed by single-pair fluorescence resonance energy transfer

Science.gov (United States)

Chi-Cheng, Fu; Wunshain, Fann; Yuan Hanna, S.

2006-03-01

Fis, a site-specific DNA binding protein, regulates many biological processes including recombination, transcription, and replication in E.coli. Fis induced DNA bending plays an important role in regulating these functions and bending angle range from ˜50 to 95 dependent on the DNA sequence. For instance, the average bending angle of λF-DNA (26 bp, 8.8nm long, contained λF binding site on the center) measured by gel mobility shift assays was ˜ 94 . But the traditional method cannot provide information about the dynamics and the angle distribution. In this study, λF-DNA was labeled with donor (Alexa Fluor 546) and acceptor (Alexa Fluor 647) dyes on its two 5' ends and the donor-acceptor distances were measured using single-pair fluorescence resonance energy transfer (sp-FRET) with and without the present of Fis protein. Combing with structure information of Fis-DNA complex, the sp-FRET results are used to estimate the protein induced DNA bending angle distribution and dynamics.

Late magmatic controls on the origin of schorlitic and foititic tourmalines from late-Variscan peraluminous granites of the Arbus pluton (SW Sardinia, Italy): Crystal-chemical study and petrological constraints

Science.gov (United States)

Bosi, Ferdinando; Naitza, Stefano; Skogby, Henrik; Secchi, Francesco; Conte, Aida M.; Cuccuru, Stefano; Hålenius, Ulf; De La Rosa, Nathaly; Kristiansson, Per; Charlotta Nilsson, E. J.; Ros, Linus; Andreozzi, Giovanni B.

2018-05-01

Tourmalines from the late-Variscan Arbus pluton (SW Sardinia) and its metamorphic aureole were structurally and chemically characterized by single-crystal X-ray diffraction, electron and nuclear microprobe analysis, Mössbauer, infrared and optical absorption spectroscopy, to elucidate their origin and relationships with the magmatic evolution during the pluton cooling stages. The Arbus pluton represents a peculiar shallow magmatic system, characterized by sekaninaite (Fe-cordierite)-bearing peraluminous granitoids, linked via AFC processes to gabbroic mantle-derived magmas. The Fe2+-Al-dominant tourmalines occur in: a) pegmatitic layers and pods, as prismatic crystals; b) greisenized rocks and spotted granophyric dikes, as clots or nests of fine-grained crystals in small miaroles locally forming orbicules; c) pegmatitic veins and pods close to the contacts within the metamorphic aureole. Structural formulae indicate that tourmaline in pegmatitic layers is schorl, whereas in greisenized rocks it ranges from schorl to fluor-schorl. Tourmalines in thermometamorphosed contact aureole are schorl, foitite and Mg-rich oxy-schorl. The main substitution is Na + Fe2+ ↔ □ + Al, which relates schorl to foitite. The homovalent substitution (OH) ↔ F at the O1 crystallographic site relates schorl to fluor-schorl, while the heterovalent substitution Fe2+ + (OH, F) ↔ Al + O relates schorl/fluor-schorl to oxy-schorl. Tourmaline crystallization in the Arbus pluton was promoted by volatile (B, F and H2O) enrichment, low oxygen fugacity and Fe2+ activity. The mineralogical evolutive trend is driven by decreasing temperature, as follows: sekaninaite + quartz → schorl + quartz → fluor-schorl + quartz → foitite + quartz. The schorl → foitite evolution represents a distinct trend towards (Al + □) increase and unit-cell volume decrease. These trends are typical of granitic magmas and consistent with Li-poor granitic melts, as supported by the absence of elbaite and other

Integration plan required by performance agreement SM 7.2.1

International Nuclear Information System (INIS)

Diediker, L.P.

1997-01-01

Fluor Daniel Hanford, Inc. and its major subcontractors are in agreement that environmental monitoring performed under the Project Hanford Management Contract is to be done in accordance with a single, integrated program. The purpose of this Integration Plan for Environmental Monitoring is to document the policies, systems, and processes being put in place to meet one key objective: manage and integrate a technically competent, multi-media ambient environmental monitoring program, in an efficient, cost effective manner. Fluor Daniel Hanford, Inc. and its major subcontractors also commit to conducting business in a manner consistent with the International Standards Organization 14000 Environmental Management System concepts. Because the integration of sitewide groundwater monitoring activities is managed by the Environmental Restoration Contractor, groundwater monitoring it is outside the scope of this document. Therefore, for the purpose of this Integration Plan for Environmental Monitoring, the Integrated Environmental Monitoring Program is defined as applicable to all environmental media except groundwater. This document provides recommendations on future activities to better integrate the overall environmental monitoring program, with emphasis on the near-field program. In addition, included is the Fluor Daniel Hanford, Inc. team review of the environmental monitoring activities on the Hanford Site, with concurrence of Pacific Northwest National Laboratory and Bechtel Hanford, Inc. (The narrative provided later in the Discussion Section describes the review and consideration given to each topic.) This document was developed to meet the requirements of the Project Hanford Management Contract performance agreement (SM7.2) and the tenets of the U.S. Department of Energy's Effluent and Environmental Monitoring Planning Process. This Plan is prepared for the U.S. Department of Energy, Richland Operations Office, Environmental Assurance, Permits, and Policy Division

Phase 1 Final Report for In-Situ Tritium Beta Detector

Energy Technology Data Exchange (ETDEWEB)

Berthold, J.W.; Jeffers, L.A.

1998-04-15

The objectives of this three-phase project were to design, develop, and demonstrate a monitoring system capable of detecting and quantifying tritium in situ in ground and surface waters, and in water from effluent lines prior to discharge into public waterways. The tritium detection system design is based on measurement of the low energy beta radiation from the radioactive decay of tritium using a special form of scintillating optical fiber directly in contact with the water to be measured. The system consists of the immersible sensor module containing the optical fiber, and an electronics package, connected by an umbilical cable. The system can be permanently installed for routine water monitoring in wells or process or effluent lines, or can be moved from one location to another for survey use. The electronics will read out tritium activity directly in units of pico Curies per liter, with straightforward calibration. In Phase 1 of the project, we characterized the sensitivity of fluor-doped plastic optical fiber to tritium beta radiation. In addition, we characterized the performance of photomultiplier tubes needed for the system. In parallel with this work, we defined the functional requirements, target specifications, and system configuration for an in situ tritium beta detector that would use the fluor-doped fibers as primary sensors of tritium concentration in water. The major conclusions from the characterization work are: A polystyrene optical fiber with fluor dopant concentration of 2% gave best performance. This fiber had the highest dopant concentration of any fibers tested. Stability may be a problem. The fibers exposed to a 22-day soak in 120 F water experienced a 10x reduction in sensitivity. It is not known whether this was due to the build up of a deposit (a potentially reversible effect) or an irreversible process such as leaching of the scintillating dye.

Test Plan: Sludge Treatment Project Corrosion Process Chemistry Follow-on Testing

Energy Technology Data Exchange (ETDEWEB)

Delegard, Calvin H.; Schmidt, Andrew J.; Poloski, Adam P.

2007-08-17

This test plan was prepared by the Pacific Northwest National Laboratory (PNNL) under contract with Fluor Hanford (FH). The test plan describes the scope and conditions to be used to perform laboratory-scale testing of the Sludge Treatment Project (STP) hydrothermal treatment of K Basin sludge. The STP, managed for the U. S. Department of Energy (DOE) by FH, was created to design and operate a process to eliminate uranium metal from the sludge prior to packaging for Waste Isolation Pilot Plant (WIPP) by using high temperature liquid water to accelerate the reaction, produce uranium dioxide from the uranium metal, and safely discharge the hydrogen. The proposed testing builds on the approach and laboratory test findings for both K Basin sludge and simulated sludge garnered during prior testing from September 2006 to March 2007. The outlined testing in this plan is designed to yield further understanding of the nature of the chemical reactions, the effects of compositional and process variations and the effectiveness of various strategies to mitigate the observed high shear strength phenomenon observed during the prior testing. These tests are designed to provide process validation and refinement vs. process development and design input. The expected outcome is to establish a level of understanding of the chemistry such that successful operating strategies and parameters can be implemented within the confines of the existing STP corrosion vessel design. In July 2007, the DOE provided direction to FH regarding significant changes to the scope of the overall STP. As a result of the changes, FH directed PNNL to stop work on most of the planned activities covered in this test plan. Therefore, it is unlikely the testing described here will be performed. However, to preserve the test strategy and details developed to date, the test plan has been published.

HWVP submerged bed scrubber waste treatment by ion exchange at high pH

International Nuclear Information System (INIS)

Bray, L.A.; Carson, K.J.; Elovich, R.J.; Eakin, D.E.

1996-03-01

The Hanford Waste Vitrification Plant (HWVP) is expected to produce aqueous waste streams that will require further processing for cesium, strontium, and transuranic (TRU) removal prior to incorporation into grout. Fluor Daniel, Inc. has recommended that zeolite be added to these waste streams for adsorption of cesium (Cs) and strontium (Sr) following pH adjustment by sodium hydroxide (NAOH) addition. Filtration will then used to remove the TRU elements associated with the process solids and the zeolite containing the Cs and Sr

HWVP submerged bed scrubber waste treatment by ion exchange at high pH

Energy Technology Data Exchange (ETDEWEB)

Bray, L.A.; Carson, K.J.; Elovich, R.J.; Eakin, D.E.

1996-03-01

The Hanford Waste Vitrification Plant (HWVP) is expected to produce aqueous waste streams that will require further processing for cesium, strontium, and transuranic (TRU) removal prior to incorporation into grout. Fluor Daniel, Inc. has recommended that zeolite be added to these waste streams for adsorption of cesium (Cs) and strontium (Sr) following pH adjustment by sodium hydroxide (NAOH) addition. Filtration will then used to remove the TRU elements associated with the process solids and the zeolite containing the Cs and Sr.

Comparison of a chimeric anti-carcinoembryonic antigen antibody conjugated with visible or near-infrared fluorescent dyes for imaging pancreatic cancer in orthotopic nude mouse models

Science.gov (United States)

Maawy, Ali A.; Hiroshima, Yukihiko; Kaushal, Sharmeela; Luiken, George A.; Hoffman, Robert M.; Bouvet, Michael

2013-12-01

The aim of this study was to evaluate a set of visible and near-infrared dyes conjugated to a tumor-specific chimeric antibody for high-resolution tumor imaging in orthotopic models of pancreatic cancer. BxPC-3 human pancreatic cancer was orthotopically implanted into pancreata of nude mice. Mice received a single intravenous injection of a chimeric anti-carcinoembryonic antigen antibody conjugated to one of the following fluorophores: 488-nm group (Alexa Fluor 488 or DyLight 488); 550-nm group (Alexa Fluor 555 or DyLight 550); 650-nm group (Alexa Fluor 660 or DyLight 650), or the 750-nm group (Alexa Fluor 750 or DyLight 755). After 24 h, the Olympus OV100 small-animal imaging system was used for noninvasive and intravital fluorescence imaging of mice. Dyes were compared with respect to depth of imaging, resolution, tumor-to-background ratio (TBR), photobleaching, and hemoglobin quenching. The longer wavelength dyes had increased depth of penetration and ability to detect the smallest tumor deposits and provided the highest TBRs, resistance to hemoglobin quenching, and specificity. The shorter wavelength dyes were more photostable. This study showed unique advantages of each dye for specific cancer imaging in a clinically relevant orthotopic model.

Environmental releases for calendar year 1996

International Nuclear Information System (INIS)

Greager, E.M.

1997-01-01

This report presents data on radioactive and nonradioactive materials released into the environment during calendar year 1996 from facilities and activities managed by the Fluor Daniel Hanford, Incorporated (formerly the Westinghouse Hanford Company) and Bechtel Hanford, Incorporated. Fluor Daniel Hanford, Incorporated provides effluent monitoring services for Bechtel Hanford, Incorporated, which includes release reporting. Both summary and detailed presentations of the environmental releases are provided. When appropriate, comparisons to data from previous years are made

Environmental releases for calendar year 1996

Energy Technology Data Exchange (ETDEWEB)

Greager, E.M.

1997-07-31

This report presents data on radioactive and nonradioactive materials released into the environment during calendar year 1996 from facilities and activities managed by the Fluor Daniel Hanford, Incorporated (formerly the Westinghouse Hanford Company) and Bechtel Hanford, Incorporated. Fluor Daniel Hanford, Incorporated provides effluent monitoring services for Bechtel Hanford, Incorporated, which includes release reporting. Both summary and detailed presentations of the environmental releases are provided. When appropriate, comparisons to data from previous years are made.

F{sup 19} relaxation in non-magnetic hexafluorides; Contribution a l'etude de la relaxation des fluors dans les hexafluorures non magnetiques

Energy Technology Data Exchange (ETDEWEB)

Rigny, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-12-01

The interesting properties of the fluorine magnetic resonance in the hexafluorides of molybdenum, tungsten and uranium, are very much due to large anisotropies of the chemical shift tensors. In the solid phases these anisotropies, the values of which are deduced from line shape studies, allow one to show that the molecules undergo hindered rotations about the metal atom. The temperature and frequency dependence of the fluorine longitudinal relaxation times shows that the relaxation is due to the molecular motion. The dynamical parameters of this motion are then deduced from the complete study of the fluorine relaxation in the rotating frame. In the liquid phases, the existence of anisotropies allows an estimation of the different contributions to the relaxation. In particular, the frequency and temperature dependence of the relaxation shows it to be dominated by the spin-rotation interaction. We have shown that the strength of this interaction can be deduced from the chemical shifts, and the angle through which the molecule rotates quasi-freely can be determined. In the hexafluorides, this angle is roughly one radian at 70 C, and with the help of this value, the friction coefficients which describe the intermolecular interactions are discussed. (author) [French] Les proprietes de la resonance magnetique des fluors dans les hexafluorures de molybdene, tungstene et uranium sont influencees par l'existence de deplacements chimiques tres anisotropes. Dans les phases solides, la valeur de cette anisotropie peut etre determinee par l'analyse des formes de raies et son existence permet de montrer que les molecules sont en rotation empechee autour de leur atome central. L'etude du temps de relaxation longitudinal en fonction de la temperature et de la frequence montre que la relaxation est due aux mouvements moleculaires, aux plus hautes temperatures. Les proprietes dynamiques du mouvement sont obtenues par l'etude complete de la relaxation spin-reseau dans le referentiel

European Scientific Notes. Volume 37, Numbers 12.

Science.gov (United States)

1983-12-01

being flown on GAMMA-i, a Russian the local matter is not in the form of mission planned for 1984-85 as a French- ordinary baryonic mass (e.g., neutrons...probe the structure of the electric field in collective ion acceleration experiments. Energy-Transfer Processes in Condensed Matter ...Denmark) examined distribu- fields in straits regions. tions of suspended matter and fluore- Other areas of straits research are scence in straits

Interest of a simple on-line screening registry for measuring ICU burden related to an influenza pandemic.

Science.gov (United States)

Richard, Jean-Christophe Marie; Pham, Tài; Brun-Buisson, Christian; Reignier, Jean; Mercat, Alain; Beduneau, Gaëtan; Régnier, Bernard; Mourvillier, Bruno; Guitton, Christophe; Castanier, Matthias; Combes, Alain; Le Tulzo, Yves; Brochard, Laurent

2012-07-09

The specific burden imposed on Intensive Care Units (ICUs) during the A/H1N1 influenza 2009 pandemic has been poorly explored. An on-line screening registry allowed a daily report of ICU beds occupancy rate by flu infected patients (Flu-OR) admitted in French ICUs. We conducted a prospective inception cohort study with results of an on-line screening registry designed for daily assessment of ICU burden. Among the 108 centers participating to the French H1N1 research network on mechanical ventilation (REVA) - French Society of Intensive Care (SRLF) registry, 69 ICUs belonging to seven large geographical areas voluntarily participated in a website screening-registry. The aim was to daily assess the ICU beds occupancy rate by influenza-infected and non-infected patients for at least three weeks. Three hundred ninety-one critically ill infected patients were enrolled in the cohort, representing a subset of 35% of the whole French 2009 pandemic cohort; 73% were mechanically ventilated, 13% required extra corporal membrane oxygenation (ECMO) and 22% died. The global Flu-OR in these ICUs was only 7.6%, but it exceeded a predefined 15% critical threshold in 32 ICUs for a total of 103 weeks. Flu-ORs were significantly higher in University than in non-University hospitals. The peak ICU burden was poorly predicted by observations obtained at the level of large geographical areas. The peak Flu-OR during the pandemic significantly exceeded a 15% critical threshold in almost half of the ICUs, with an uneven distribution with time, geographical areas and between University and non-University hospitals. An on-line assessment of Flu-OR via a simple dedicated registry may contribute to better match resources and needs.

Reengineering and health physics within the project Hanford management contract

International Nuclear Information System (INIS)

Atencio, E.M.

1997-01-01

The impending transition of the Hartford Site management and operations (M ampersand O) contract to a management and integrating (M ampersand I) contract format, together with weak radiological performance assessments by external organizations and reduced financial budgets prompted the 're-engineering' of the previous Hanford prime contractor Radiological Control (Rad Con) organization. This paper presents the methodology, identified areas of improvements, and results of the re-engineering process. The conversion from the M ampersand O to the M ampersand I contract concept resulted in multiple independent Rad Con organizations reporting to separate major contractors who are managed by an integrating contractor. This brought significant challenges when establishing minimum site standards for sitewide consistency, developing roles and responsibilities, and maintaining site Rad Con goals. Championed by the previous contractor's Rad Con Director, Denny Newland, a five month planning effort was executed to address the challenges of the M ampersand I and to address identified weaknesses. Fluor Daniel Hanford assumed the responsibility as integrator of the Project Hanford Management Contract on October 1, 1996. The Fluor Daniel Hanford Radiation Protection Director Jeff Foster presents the results of the re-engineering effort, including the significant cost savings, process improvements, field support improvements, and clarification of roles and responsibilities that have been achieved

Influence of gamma irradiation on electro active properties of copolymers of vinylidene fluoride with tetrafluoroethylene

International Nuclear Information System (INIS)

Magerramov, A.M; Rustamova, D.F.

2010-01-01

Full text : Fluoropolymers are known, as one of the most promising polymers of electro active materials and they are very sensitive to radiation, with the prone to decomposition processes. One way to stabilize the piezoelectric properties of Fluor polymers may be their radiation modification of gamma-irradiation. The aim of the present work is to study the effect of gamma-irradiation on the piezoelectric properties of the copolymer of vinylidene fluoride with tetrafluoroethylene-P (VDF-TeFE). The polarization produced in the optimal range for the electric field. Irradiation of the films performed at the facility Rahm-gamma-30 both before and after polarization. For gamma irradiation, apparently as a result of conformational transitions alpha and beta is a change of relations of ferroelectric and par electric phases in upward of crystallinity, i e an increase in the ferroelectric polymer. It was discussed possible mechanisms of changes in the dielectric, piezoelectric and ferroelectric properties (hysteresis loops, the values of the coercive field) with a residual polarization of Fluor polymers when exposed to gamma-irradiation.

Cloning, characterization and chromosomal location of a satellite DNA from the Pacific oyster, Crassostrea gigas

Digital Repository Service at National Institute of Oceanography (India)

Clabby, C.; Goswami, U.; Flavin, F.; Wilkins, N.P.; Houghton, J.A.; Powell, R.

F2.18 (includ- ing pBGS8 vector) was labelled with fluor-12-dUTP and hybridized to the chromosome slides. The fluorescence signals were directly observed without additional immu- nological enhancement. No fluorescence signals were obtained when...-it-Fluor, Stratagene, La Jolla, CA, USA). Chromosomes were denatured at 72°C in 70% formamide/2 × SSC and the denatured labelled Cgl70 probe was added and hybridization performed at 37°C overnight. Post-hybridization washes were according to manufacturer...

High-speed videography combined with an x-ray image intensifier for dynamic radiography

International Nuclear Information System (INIS)

Bryant, L.E. Jr.

1983-01-01

The Spin Physics SP-2000 high-speed video system can be combined with an x-ray source, a dynamic event having internal (not directly visible) movement and an x-ray image intensifier to perform dynamic radiography. The cesium iodide input fluor and P-20 output fluor of the image intensifier have rapid decay to allow x-ray imaging up to 12,000 pictures per second. Applications of this technique include internal functioning of a compressor, turbulent-water action, and other mechanical actions

Time response measurements of LASL diagnostic detectors

International Nuclear Information System (INIS)

Hocker, L.P.

1970-07-01

The measurement and data analysis techniques developed under the Los Alamos Scientific Laboratory's detector improvement program were used to characterize the time and frequency response of selected LASL Compton, fluor-photodiode (NPD), and fluor-photomultiplier (NPM) diagnostic detectors. Data acquisition procedures and analysis methods presently in use are summarized, and detector time and frequency data obtained using the EG and G/AEC electron linear accelerator fast pulse (approximately 50 psec FWHM) as the incident radiation driving function are presented. (U.S.)

Porous silicon: some new applications of this material with astonishing properties; Le silicium poreux: nouvelles applications de ce materiau aux proprietes remarquables

Energy Technology Data Exchange (ETDEWEB)

Gauthier-Manuel, B. [Laboratoire FEMTO-ST, Dept. MN2S, CNRS UMR 6174, 25 - Besancon (France)

2009-02-15

Anodic oxidation of silicon wafer in fluor-hydric acid solution leads to a porous material with surprising properties. Structures at nano-metric scale are source of deep photoluminescence. The very large scale of pore size available and the high specific surface obtained allows optical and microfabrication applications. This paper describes the electrochemical process of this material, some characterization methods, and some new applications in the fields of micro-energy and molecular separation. (author)

Mobile Work Platform - A Fluor Fernald innovative dismantlement technology

International Nuclear Information System (INIS)

Peters, Mark S.; Cromer, Paul R.; Danner, Robert

2000-01-01

The Department of Energy's (DOE) Office of Science and Technology Decontamination and Decommissioning (D andD) Focus Area, led by the National Energy Technology Laboratory, has been charged with finding new and innovative D and D technologies and then validating through field demonstration that the technologies are safer, faster and/or more cost-effective. The D and D Focus Area's approach to verifying the benefits of the improved D and D technologies is to use them at DOE sites in large-scale demonstration and deployment (LSDD) projects. The DOE's Fernald Environmental Management Project (FEMP), near Cincinnati Ohio, was host for a LSDD Project overseen by the D and D Focus Area. The FEMP was formerly engaged in the production of high quality uranium metal; and is now currently undergoing active environmental restoration, including removal of major process facilities. As observed during the D and D of Fernald's Plant 1, the baseline method for removing piping required laborers to work above the floor on ladders, scaffolding, ardor man-lifts with hand-held power tools. The pipe must first be rigged to prevent falling when cut. After cutting, the pipe is manually lowered to the ground and placed in a storage/disposal container. The Mobile Work Platform (MWP) consists of a mobile chassis, telescoping arm and a dual crimper/shear ''end-effecter''. It has the capability to grab and hold a pipe, crimp and shear the pipe (up to a ten-foot section) on either side of where it is being held and then lower and place the pipe section into a storage/disposal container. The MWP can crimp/shear up to a 6-inch diameter, schedule 401, carbon steel pipe. A single operator using a radio remote control operates the MWP. The paper will describe the results (productivity, safety advantages and lessons learned) during the Mobile Work Platform demonstration at Fernald

Mobile Work Platform - A Fluor Fernald innovative dismantlement technology

Energy Technology Data Exchange (ETDEWEB)

Mark S. Peters; Paul R. Cromer; Robert Danner

2000-06-16

The Department of Energy's (DOE) Office of Science and Technology Decontamination and Decommissioning (D&D) Focus Area, led by the National Energy Technology Laboratory, has been charged with finding new and innovative D&D technologies and then validating through field demonstration that the technologies are safer, faster and/or more cost-effective. The D&D Focus Area's approach to verifying the benefits of the improved D&D technologies is to use them at DOE sites in large-scale demonstration and deployment (LSDD) projects. The DOE's Fernald Environmental Management Project (FEMP), near Cincinnati Ohio, was host for a LSDD Project overseen by the D&D Focus Area. The FEMP was formerly engaged in the production of high quality uranium metal; and is now currently undergoing active environmental restoration, including removal of major process facilities. As observed during the D&D of Fernald's Plant 1, the baseline method for removing piping required laborers to work above the floor on ladders, scaffolding, ardor man-lifts with hand-held power tools. The pipe must first be rigged to prevent falling when cut. After cutting, the pipe is manually lowered to the ground and placed in a storage/disposal container. The Mobile Work Platform (MWP) consists of a mobile chassis, telescoping arm and a dual crimper/shear ''end-effecter''. It has the capability to grab and hold a pipe, crimp and shear the pipe (up to a ten-foot section) on either side of where it is being held and then lower and place the pipe section into a storage/disposal container. The MWP can crimp/shear up to a 6-inch diameter, schedule 401, carbon steel pipe. A single operator using a radio remote control operates the MWP. The paper will describe the results (productivity, safety advantages and lessons learned) during the Mobile Work Platform demonstration at Fernald.

Central melanopsin projections in the diurnal rodent, Arvicanthis niloticus

DEFF Research Database (Denmark)

Langel, Jennifer L; Smale, Laura; Esquiva, Gema

2015-01-01

projections of ipRGCs by examining the distribution of immunoreactive PACAP fibers in intact and enucleated animals. This revealed evidence that these cells project to the suprachiasmatic nucleus, lateral geniculate nucleus (LGN), pretectum, and superior colliculus. This distribution was confirmed...... with injections of cholera toxin subunit β coupled with Alexa Fluor 488 in one eye and Alexa Fluor 594 in the other, combined with IHC staining of PACAP. These studies also revealed that the ventral and dorsal LGN and the caudal olivary pretectal nucleus receive less innervation from ipRGCs than that reported...

SEISMIC DESIGN REQUIREMENTS SELECTION METHODOLOGY FOR THE SLUDGE TREATMENT and M-91 SOLID WASTE PROCESSING FACILITIES PROJECTS

International Nuclear Information System (INIS)

RYAN GW

2008-01-01

In complying with direction from the U.S. Department of Energy (DOE), Richland Operations Office (RL) (07-KBC-0055, 'Direction Associated with Implementation of DOE-STD-1189 for the Sludge Treatment Project,' and 08-SED-0063, 'RL Action on the Safety Design Strategy (SDS) for Obtaining Additional Solid Waste Processing Capabilities (M-91 Project) and Use of Draft DOE-STD-I 189-YR'), it has been determined that the seismic design requirements currently in the Project Hanford Management Contract (PHMC) will be modified by DOE-STD-1189, Integration of Safety into the Design Process (March 2007 draft), for these two key PHMC projects. Seismic design requirements for other PHMC facilities and projects will remain unchanged. Considering the current early Critical Decision (CD) phases of both the Sludge Treatment Project (STP) and the Solid Waste Processing Facilities (M-91) Project and a strong intent to avoid potentially costly re-work of both engineering and nuclear safety analyses, this document describes how Fluor Hanford, Inc. (FH) will maintain compliance with the PHMC by considering both the current seismic standards referenced by DOE 0 420.1 B, Facility Safety, and draft DOE-STD-1189 (i.e., ASCE/SEI 43-05, Seismic Design Criteria for Structures, Systems, and Components in Nuclear Facilities, and ANSI ANS 2.26-2004, Categorization of Nuclear Facility Structures, Systems and Components for Seismic Design, as modified by draft DOE-STD-1189) to choose the criteria that will result in the most conservative seismic design categorization and engineering design. Following the process described in this document will result in a conservative seismic design categorization and design products. This approach is expected to resolve discrepancies between the existing and new requirements and reduce the risk that project designs and analyses will require revision when the draft DOE-STD-1189 is finalized

Study of copper fluorination; Contribution a l'etude de la fluoruration du cuivre

Energy Technology Data Exchange (ETDEWEB)

Gillardeau, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1967-02-01

This report deals with the action of fluorine on copper. Comprehensive descriptions are given of the particular technological methods and of the preparation of the reactants. This fluorination reaction has been studied at medium and low fluorine pressures. A nucleation and growth phenomenon is described. The influence of a pollution of the gas phase on the fluorination process is described. The solid-state reaction between cupric fluoride and cooper has also been studied. A special study has been made of the growth of copper deposits by thermal decomposition of gaseous fluorides. (author) [French] Ce rapport traite de la reaction du fluor sur le cuivre. Les methodes technologiques particulieres ainsi que les preparations des reactifs sont largement developpees. Cette reaction de fluoruration est etudiee sous pressions moyennes et sous basses pressions de fluor. Un phenomene de germination et croissance est decrit. L'influence de la pollution de la phase gazeuse sur le processus de fluoruration est rapportee. La reaction a l'etat solide du fluorure cuivrique sur le cuivre a egalement ete etudiee. La croissance de depots de cuivre par decomposition thermique des fluorures de cuivre gazeux fait l'objet d'une etude speciale. (auteur)

Use of flow scintillation analyzer combined with amino acid analyzer for measuring low-level radioactivity of tritium-labelled amino acids

CERN Document Server

Lukashina, E V; Fedoseev, V M; Ksenofontov, A L; Baratova, L A; Dobrov, E N

2002-01-01

Potential application of the Radiomatic 150TR Flow Scintillation Analyzer (Packard Instrument Co., USA) for measuring low radioactivity of tritium-labelled amino acids in eluate from the Amino Acid Analyzer 835 (Hitachi, Japan) was studied. Six scintillating cocktails were tested and the Hionic-Fluor and Ultima-Flo AP cocktails proved the most appropriate for flow measurement of radioactivity. Efficiency of tritium radioactivity recording under various conditions of analysis was determined. Under optimal conditions the lower detection limit for the Hionic-Fluor was 150, while for Ultima-Flo AP-100 decays/min in the peak of amino acid

Investigation of Chemical Durability Mechanisms and Structure of Fluoride Glasses.

Science.gov (United States)

1988-03-01

Compositions of fluorozirconate glasses (mol%) mnemonic ZrF 4 BaF 2 LaF 3 A1F 3 LiF source ZBLA 57 36 3 4 -- RADC* ZBLA-F 51.16 38.62 5.66 4.56 -- Le Verre ...Fluore4 ZBLAL 51.8 20.0 5.3 3.3 19.6 NRL * Rome Air Development Center, Hanscom AFB, MA (Dr. El Bayoumi) # Le Verre Fluore’ Co., LeMans, France " Naval...Maine, LeMans, France, (with partial support from the French Foreign Office), studied corrosion of UF4 -based fluorides. - Michel Le Toullec - 10/86

Comparison between non-dedicated positron emission tomography (NPET) with [F18] Fluor Deoxi glucose (FDG)and Radionuclide-labeled somatostatin analogues for the diagnostic purposes in the Differential Thyroid Cancer

International Nuclear Information System (INIS)

Escobar, E.I.; Giammarile, G.F.; Borson-Chazot, B.F.; Hasdi, H.Z.; Sassolas, S.G.

2002-01-01

Aim: Evaluation of sensibility in the diagnosis of metastasis or recurrence in Differential Thyroid Cancer in patients with elevated Thyroglobulin plasmatic level and a Negative Whole Body Iodine 131 scan. Material and Method: 23 patients with a differential thyroid cancer were included in this study (13 papillary cancer, 5 Follicular, 3 Hurtle cell and 1 insular), all of which had an elevated plasmatic level of thyroglobulin and negative scan performed after high doses of 131 Iodine. The results of Fluor deoxi glucose scan and Octreoscan were made independently of two observers and were confirmed afterwards with TAC, Ultrasound, histopathologic findings and the follow-up. The Octreoscan was performed under defrenation status. Results: The FDG scan has revealed 13/23 positive scan, the octreoscan 9/23 with a Sensibility of 6%, 39% and 60.8% respectively. In 17 studies the FDG scan and octreoscan concord. Besides, in 6 studies there was no concordance between FDG and octreoscan; 5 of which correspond to 5 false negative for octreoscan and 1 false negative of FDG. The level of plasmatic thyroglobulin was not an indicator of the presence of positive scans. Among false negative exams in FDG scan and ostreoscan, there were 8 cases of adenopathies cervical and 1 pulmonary metastasis. In the analysis of lesion site, we founded a mismatched between FDG and octreoscan: the FDG could identify 2 bone metastasis, 3 pulmonary metastasis, 2 cervical adenophaties, and 1 mediastinal focus where octreoscan was negative. Likewise, the octreoscan found 3 mediastinal metastasis correctly and 1 pulmonary metastasis where FDG was negative. Conclusion: In the search of a metastasis or recurrence for differential thyroid cancer, when the thyroglobulin is elevated and the whole body scan is negative, the FDG scan and octreoscan could have their indication. As a result, we can conclude that the FDG scan is a good tool and the study with octreoscan, on the contrary, shows a lower utilization

Fluor Hanford ALARA Center is a D and D Resource

International Nuclear Information System (INIS)

Waggoner, L.O.

2008-01-01

The mission at the Hanford Nuclear Reservation changed when the last reactor plant was shut down in 1989 and work was started to place all the facilities in a safe condition and begin decontamination, deactivation, decommissioning, and demolition (D and D). These facilities consisted of old shutdown reactor plants, spent fuel pools, processing facilities, and 177 underground tanks containing 53 million gallons of highly radioactive and toxic liquids and sludge. New skills were needed by the workforce to accomplish this mission. By 1995, workers were in the process of getting the facilities in a safe condition and it became obvious improvements were needed in their tools, equipment and work practices. The Hanford ALARA Program looked good on paper, but did little to help contractors that were working in the field. The Radiological Control Director decided that the ALARA program needed to be upgraded and a significant improvement could be made if workers had a place they could visit that had samples of the latest technology and could talk to experienced personnel who have had success doing D and D work. Two senior health physics personnel who had many years experience in doing radiological work were chosen to obtain tools and equipment from vendors and find a location centrally located on the Hanford site. Vendors were asked to loan their latest tools and equipment for display. Most vendors responded and the Hanford ALARA Center of Technology opened on October 1, 1996. Today, the ALARA Center includes a classroom for conducting training and a mockup area with gloveboxes. Two large rooms have a containment tent, several glove bags, samples of fixatives/expandable foam, coating displays, protective clothing, heat stress technology, cutting tools, HEPA filtered vacuums, ventilation units, pumps, hydraulic wrenches, communications equipment, shears, nibblers, shrouded tooling, and several examples of innovative tools developed by the Hanford facilities. See Figures I and

Qualification for Safeguards Purposes of UF6 Sampling using Alumina – Results of the Evaluation Campaign of ABACC-Cristallini Method

OpenAIRE

ESTAEBAN ADOLFO; GAUTIER EDUARDO; MACHADO DA SILVA LUIS; FERNANDEZ MORENO SONIA; RENHA JR GERALDO; DIAS FABIO; PEREIRA DE OLIVEIRA JUNIOR OLIVIO; AMMARAGGI DAVID; MASON PETER; SORIANO MICHAEL; CROATTO PAUL; ZULEGER EVELYN; GIAQUINTO JOSEPH; HEXEL COLE; VERCOUTER THOMAS

2017-01-01

The procedure currently used to sample material from process lines in uranium enrichment plants consists of collecting the uranium hexafluoride (UF6) in gaseous phase by desublimation inside a metal sampling cylinder cooled with liquid nitrogen or in certain facilities in a fluorothene P-10 tube type. The ABACC-Cristallini method (A-C method) has been proposed to collect the UF6 (gas) by adsorption in alumina (Al2O3) in the form of uranyl fluoride (UO2F2) (solid). This method uses a fluor...

Kinetic study of the fluorination by fluorine of some uranium and plutonium compounds; Etude cinetique de la fluoration par le fluor de quelques composes de l'uranium et du plutonium

Energy Technology Data Exchange (ETDEWEB)

Vandenbussche, G [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

1964-12-15

The study of fluorination reactions of uranium and plutonium compounds with elementary fluorine, has been carried out using a thermogravimetric method. These reactions are heterogeneous ones, and of the following type: S(solid) + G{sub 1}(gas) - G{sub 2}(gas). The kinetics of these reactions correspond to a uniform attack of the entire surface of the sample. {alpha}: being the degree of completion of the reaction, k(rel): being the relative rate of penetration of the reaction interface, t: being the time, one have the relation: (1-{alpha}){sup 1/3} = 1 - k(rel)*t. The mechanism of the reaction varies according to the nature of the compound: 1) with uranium tetrafluoride and plutonium tetrafluoride, the reaction proceeds in a single step; 2) with uranium oxides, the reaction proceeds in two steps, uranium oxyfluoride being the intermediate compound; 3) with plutonium oxide, the reaction proceeds in two steps, plutonium tetrafluoride being the intermediate compound; and 4) with uranium trichloride, the mechanism is complex: chlorine trifluoride is formed. (author) [French] L'etude des reactions de fluoration par le fluor, de composes de l'uranium et du plutonium a ete faite par thermogravimetrie. Ce sont des reactions heterogenes du type: S(solide) + G{sub 1}(gaz) - G{sub 2}(gaz). La cinetique de ces reactions est celle correspondant a une attaque uniforme de toute la surface de l'echantillon. Si {alpha}: est le degre d'avancement de la reaction, k(rel): est la vitesse relative d'avancement d'un interface reactionnel, t: le temps. On a la relation: (1-{alpha}){sup 1/3} = 1-k(rel)*t. Le mecanisme de la reaction varie selon la nature du compose: 1) tetrafluorure d'uranium et tetrafluorure de plutonium, la reaction s'effectue en un seul stade; 2) Oxydes d'uranium: la reaction s'effectue en deux stades, l'oxyfluorure d'uranium est le compose intermediaire; 3) oxyde de plutonium, la reaction s'effectue en deux stades, la tetrafluorure de plutonium est le compose

Normal maintenance costs drop at Duke Power: Impact of Hurricane Hugo being assessed

International Nuclear Information System (INIS)

Anon.

1990-01-01

William S. Lee, chairman and president of Duke Power Company, said that a third-quarter earnings increase was primarily due to lower plant maintenance costs, but that figures aren't in yet on the damages related to Hurricane Hugo, which ripped through the Carolinas in late September. The severity of this storm is unprecedented in the company's history, he said. Lee also announced that Duke Power has entered into a new partnership with the Fluor Corporation, of Irvine, California. The two companies, operating under the name Duke/Fluor Daniel, will offer the power industry a single source of design, engineering, construction, and operation services for new and existing coal-fired plants

Preparation of plastic scintillator detectors and physicochemical parameter characterization

International Nuclear Information System (INIS)

Hamada, M.M.; Mesquita, C.H. de.

1988-10-01

The development of plastic scintillators for use in the nuclear radiation detection is described. The detectors were fabricated by the polymerization of styrene with organic fluors. The organic fluors used were PPO (1,4 diphenyl-oxazol) and POPOP 1,4-di-2-(5-phenyl-oxazolil) - benzene in proportions of 0,5 and 0,05% respectively. Physicochemical parameters related to the quality of this detector are investigated at this laboratory. The evaluation of its fluorescence characteristics, density, melting softening, refractive index, molecular weight, gamma and alpha spectrometry characteristics and finally the comparative pulse height analysis indicate that the plastic scintillator produced at this laboratory is comparable with others already described. (author)

The Challenges of Preserving Historic Resources During the Deactivation and Decommissioning of Highly Contaminated Historically Significant Plutonium Process Facilities

International Nuclear Information System (INIS)

Hopkins, A.; Minette, M.; Sorenson, D.; Heineman, R.; Gerber, M.; Charboneau, S.; Bond, F.

2006-01-01

The Manhattan Project was initiated to develop nuclear weapons for use in World War II. The Hanford Engineer Works (HEW) was established in eastern Washington State as a production complex for the Manhattan Project. A major product of the HEW was plutonium. The buildings and process equipment used in the early phases of nuclear weapons development are historically significant because of the new and unique work that was performed. When environmental cleanup became Hanford's central mission in 1991, the Department of Energy (DOE) prepared for the deactivation and decommissioning of many of the old process facilities. In many cases, the process facilities were so contaminated, they faced demolition. The National Historic Preservation Act (NHPA) requires federal agencies to evaluate the historic significance of properties under their jurisdiction for eligibility for inclusion in the National Register of Historic Places before altering or demolishing them so that mitigation through documentation of the properties can occur. Specifically, federal agencies are required to evaluate their proposed actions against the effect the actions may have on districts, sites, buildings or structures that are included or eligible for inclusion in the National Register. In an agreement between the DOE's Richland Operations Office (RL), the Washington State Historic Preservation Office (SHPO) and the Advisory Council on Historic Preservation (ACHP), the agencies concurred that the Hanford Site Historic District is eligible for listing on the National Register of Historic Places and that a Site-wide Treatment Plan would streamline compliance with the NHPA while allowing RL to manage the cleanup of the Hanford Site. Currently, many of the old processing buildings at the Plutonium Finishing Plant (PFP) are undergoing deactivation and decommissioning. RL and Fluor Hanford project managers at the PFP are committed to preserving historical artifacts of the plutonium production process. They

Radon Reduction Experience at a Former Uranium Processing Facility

International Nuclear Information System (INIS)

Eger, K. J.; Rutherford, L.; Rickett, K.; Fellman, R.; Hungate, S.

2004-01-01

Approximately 6,200 cubic meters of waste containing about 2.0E8 MBq of radium-226 are stored in two large silos at the Fernald Site in southwest Ohio. The material is scheduled for retrieval, packaging, off site shipment and disposal by burial. Air in the silos above the stored material contained radon-222 at a concentration of 7.4 E5 Bq/L. Short-lived daughters formed by decay in these headspaces generated dose rates at contact with the top of the silos up to 1.05 mSv/hr and there complicate the process of retrieval. A Radon Control System (RCS) employing carbon adsorption beds has been designed under contract with the Fluor Fernald to remove most of the radon in the headspaces and maintain lower concentrations during periods when work on or above the domes is needed. Removing the radon also removes the short-lived daughters and reduces the dose rate near the domes to 20 to 30 μSv/hr. Failing to remove the radon would be costly, in the exposure of personnel needed to work extended periods at these moderate dose rates, or in dollars for the application of remote retrieval techniques. In addition, the RCS minimizes the potential for environmental releases. This paper describes the RCS, its mode of operation, and early experiences. The results of the test described herein and the experience gained from operation of the RCS during its first phase of continuous operation, will be used to determine the best air flow, and air flow distribution, the most desirable number and sequence number and sequence of adsorption beds to be used and the optimum application of air recycle within the RCS

Scintillator detector array

International Nuclear Information System (INIS)

Cusano, D.A.; Dibianca, F.A.

1981-01-01

This patent application relates to a scintillator detector array for use in computerized tomography and comprises a housing including a plurality of chambers, the said housing having a front wall transmissive to x-rays and side walls opaque to x-rays, such as of tungsten and tantalum, a liquid scintillation medium including a soluble fluor, the solvent for the fluor being disposed in the chambers. The solvent comprises either an intrinsically high Z solvent or a solvent which has dissolved therein a high Z compound e.g. iodo or bromonaphthalene; or toluene, xylene or trimethylbenzene with a lead or tin alkyl dissolved therein. Also disposed about the chambers are a plurality of photoelectric devices. (author)

Spectrographic determination of traces of halogens; Dosage de traces d'halogenes par la methode spectrographique

Energy Technology Data Exchange (ETDEWEB)

Melamed, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1961-07-01

Hollow cathode source is employed for determining traces of halogens (fluorine - chlorine) in the uranium oxide U{sub 3}O{sub 8} qualitatively, detection of at least 40 ppm of fluorine, as alkali fluoride and 125 ppm of chlorine, is possible. (author) [French] Un tube a decharge a cathode creuse a ete utilise pour la determination spectrographique des halogenes (fluor - chlore) presentes a l'etat de traces dans un oxyde d'uranium U{sub 3}O{sub 8}. On a pu deceler qualitativement des teneurs de 40 ppm de fluor sous forme de fluorures alcalins. En ce qui concerne le chlore, la plus faible teneur decelee a ete de 125 ppm. (auteur)

Preparation of plastic scintillation detectors and characterization of physico-chemical parameters

International Nuclear Information System (INIS)

Hamada, M.M.; Mesquita, C.H. de

1988-01-01

The development of plastic scintillators for using in the nuclear radiation detection is described. The detectors were fabricated by the polymerization of styrene with organic fluors. The organic fluors used were PPO (1,4 difenil-oxazol) and POPOP 1,4-di-2-(5-fenil-oxazolil) benzene in proportions of 0,5 and 0,05% respectively. Physical-chemistry parameters related to the quality of this detector are investigated at this laboratory. The evaluation of its fluorescency characteristics, density, melting softening, refractive index, molecular weight, gama and alfa espectrometry characteristics and finally the comparative pulse height analysis indicate that the plastic scintillator produced at this laboratory is comparable with others already described. (author) [pt

Radiochromic liquid solution

International Nuclear Information System (INIS)

Noakes, J.E.; Culp, R.A.

1983-01-01

A radiochromic solution which is sensitive to small dosages of ionizing and ultraviolet radiation is described. It consists of a solution of a leucocyanide dye in a clear polar solvent with enough organic acid added to make the solution at least slightly acidic and responds to radiation by permanently changing color. Up to one half of the solution by weight can be replaced by a second solution of an aromatic solvent and an organic fluor. Another modification of the invention is a solution of a leucocyanide dye in a clear polar solvent having an aromatic group, an organic fluor, and enough organic acid to make the solution at least slightly acidic. (author)

UPDATE HANFORD SITE D and D PROGRAMS ACCELERATE EXPAND

International Nuclear Information System (INIS)

GERBER, M.S.

2004-01-01

A large, new decontamination and decommissioning organization targeted toward rapid, focused work on aging and highly contaminated structures was formed at the DOE's Hanford Site in southeast Washington state in autumn 2003. Managed by prime contractor Fluor Hanford, the new organization has made significant progress during its first six months. Under the direction of Mike Lackey, who recently joined Fluor from the Portland General Electric Trojan Plant, the Fluor Hanford DandD organization is tackling the Plutonium Finishing Plant (PFP) complex and the Fast Flux Test Facility (FFTF), and is nearly finished demolishing the 233-S Plutonium Concentration Facility. In addition, the DandD organization is progressing through the development and public comment phases of its required environmental permitting, planning work and procurement services to DandD three other Hanford facilities: 224-T and 224-B Plutonium Concentration Facilities, and the U Plant radiochemical processing facility. It is also planning and beginning to DandD the spent fuel handling areas of the Site's 100-K Reactor Area. The 586-square mile Hanford Site, the oldest plutonium production center in the world, served as the ''workhorse'' of the American nuclear defense arsenal from 1944 through 1989. Hanford produced the special nuclear material for the plutonium cores of the Trinity (test) and Nagasaki explosions, and then went on to produce more than half of the weapons plutonium ever manufactured by the United States, and about one-fourth of that manufactured worldwide. As a result, Hanford, the top-secret ''Paul Bunyan'' in the desert, is one of the most contaminated areas in the world. Its cleanup agreement with state and federal regulators, known as the ''Tri-Party Agreement,'' celebrates its 15th anniversary this spring, at a time when operations dealing with unstable plutonium leftovers, corroded spent fuel, and liquids wastes in single-shelled tanks conclude. As these crucial jobs are coming to

Integrity assessment report of tanks TK-101 and TK-102

Energy Technology Data Exchange (ETDEWEB)

MCSHANE, D.S.

1999-08-25

This Integrity Assessment Report (IAR) is prepared by Fluor Daniel Northwest (FDNW) for Waste Management Federal Services of Hanford, Inc., (WMH), the operations contractor; Fluor Daniel Hanford (FDH), the Hanford Site Manager; and the U. S. Department of Energy (DOE), the system owner. This IAR addresses the evaluation of Tanks 101 and 102 and other existing components located in the 219-S Waste Handling Facility. This report will be included in the Part B Permit for the 2226 Laboratory and is a portion of the integrity assessment of the overall 222-5 Laboratory radioactive liquid waste disposal system. This IAR is prepared in accordance with WAC 173-303, Dangerous Waste Regulations; Section 640(2), ''Assessment of Existing Tank Systems Integrity .''

Integrity assessment report of tanks TK-101 and TK-102

International Nuclear Information System (INIS)

MCSHANE, D.S.

1999-01-01

This Integrity Assessment Report (IAR) is prepared by Fluor Daniel Northwest (FDNW) for Waste Management Federal Services of Hanford, Inc., (WMH), the operations contractor; Fluor Daniel Hanford (FDH), the Hanford Site Manager; and the U. S. Department of Energy (DOE), the system owner. This IAR addresses the evaluation of Tanks 101 and 102 and other existing components located in the 219-S Waste Handling Facility. This report will be included in the Part B Permit for the 2226 Laboratory and is a portion of the integrity assessment of the overall 222-5 Laboratory radioactive liquid waste disposal system. This IAR is prepared in accordance with WAC 173-303, Dangerous Waste Regulations; Section 640(2), ''Assessment of Existing Tank Systems Integrity .''

Tolerancing requirements for remote handling at the Hanford vitrification project

International Nuclear Information System (INIS)

Keenan, R.M.; Bullis, R.E.; Van Katwijk, C.

1993-01-01

The Hanford Waste Vitrification Plant is being designed by Fluor Daniel, Inc. with WasteChem Corporation as Fluor Daniel's major subcontractor specializing in vitrification and remote system technologies. United Engineers and Constructors/Catalytic (UE ampersand C) will construct the plant. Westinghouse Hanford Company (WHC) is the Project Integration manager, manager and as the plant operator provides technical direction to the Architect/Engineer team (A/E) and constructor on behalf of the Department of Energy - Richland Field Office. The A/E has developed, in cooperation with UE ampersand C, WHC and DOE, a new and innovative approach to installations of the many remote nozzles and electrical connectors that must be installed to demanding tolerances. This paper summarizes the key elements of the HWVP approach

TRANSITION & CLOSEOUT OF THE FERNALD CLOSURE PROJECT

Energy Technology Data Exchange (ETDEWEB)

BILSON, H.E.

2007-02-01

The US Department of Energy (DOE) and Fluor Fernald have completed the majority of the cleanup of the Fernald Site. The over 1000 acre complex for processing uranium has been demolished and soil contamination has been remediated. With acres of wetlands and prairies replacing the buildings and waste pits. At the end of the project the focus shifted to developing demonstrating the completion of the project and the contract, as well as ensuring a smooth transition of the facility from the DOE's Environmental Management (EM) Program to the DOE's Legacy Management (LM) Program.

Training survey -- educational profile for Hanford HANDI 2000 project

Energy Technology Data Exchange (ETDEWEB)

Wilson, D.

1998-08-25

Fluor Daniel Hanford, Inc. (FDH) is currently adopting streamlined business processes through integrated software solutions. Replacing the legacy software (current/replacement systems, attached) also avoids significant maintenance required to resolve Year 2000 issues. This initiative is being referred to as `HANDI 2000`. The software being implemented in the first phase of this project includes Indus International`s PASSPORT Software, Peoplesoft and Primavera P3 Software. The project, which encompasses all the system replacements that will occur, has been named `HANDI 2000.` The PASSPORT applications being implemented are Inventory Management, Purchasing, Contract Management, Accounts Payable, and MSDS (Material Safety Data Sheets).

Pacific Northwest National Laboratory Apatite Investigation at the 100-NR-2 Quality Assurance Project Plan

Energy Technology Data Exchange (ETDEWEB)

Fix, N. J.

2008-03-28

This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by staff working on the 100-NR-2 Apatite Project. The U.S. Department of Energy, Fluor Hanford, Inc., Pacific Northwest National Laboratory, and the Washington Department of Ecology agreed that the long-term strategy for groundwater remediation at 100-N would include apatite sequestration as the primary treatment, followed by a secondary treatment. The scope of this project covers the technical support needed before, during, and after treatment of the targeted subsurface environment using a new high-concentration formulation.

Effect of fluoride varnish on Streptococcus mutans counts in plaque of caries-free children using Dentocult SM strip mutans test: a randomized controlled triple blind study.

Science.gov (United States)

Jeevarathan, J; Deepti, A; Muthu, M S; Rathna Prabhu, V; Chamundeeswari, G S

2007-01-01

Dental caries is one of the most prevalent infectious diseases and although of multifactorial origin, Streptococcus mutans is considered the chief pathogen in its development. Fluoride is one of the most effective agents used for the reduction of dental caries apart from oral hygiene maintenance. The aim of this study was to estimate the counts of Streptococcus mutans and to evaluate the effect of Fluor Protector fluoride varnish on these counts in the plaque of caries-free children using Dentocult SM Strip Mutans. Thirty caries-free subjects were selected for the study based on the information obtained from a questionnaire and were randomly assigned to the control group consisting of ten subjects and the study group consisting of twenty subjects. Plaque samples were collected on the strips from the Dentocult SM kit and after incubation, the presence of Streptococcus mutans was evaluated using the manufacturer's chart. The study group was subjected to a Fluor Protector fluoride varnish application following which the samples were collected again after 24 hours. The average Streptococcus mutans counts in the primary dentition of caries-free children before and after the application of Fluor Protector fluoride varnish were 10(4)-10(5) colony forming units (CFU)/ml and <10(4) CFU/ml respectively. The results showed that the study group had a statistically significant reduction in the plaque Streptococcus mutans counts than the control group.

Quantification of osmotic water transport in vivo using fluorescent albumin.

Science.gov (United States)

Morelle, Johann; Sow, Amadou; Vertommen, Didier; Jamar, François; Rippe, Bengt; Devuyst, Olivier

2014-10-15

Osmotic water transport across the peritoneal membrane is applied during peritoneal dialysis to remove the excess water accumulated in patients with end-stage renal disease. The discovery of aquaporin water channels and the generation of transgenic animals have stressed the need for novel and accurate methods to unravel molecular mechanisms of water permeability in vivo. Here, we describe the use of fluorescently labeled albumin as a reliable indicator of osmotic water transport across the peritoneal membrane in a well-established mouse model of peritoneal dialysis. After detailed evaluation of intraperitoneal tracer mass kinetics, the technique was validated against direct volumetry, considered as the gold standard. The pH-insensitive dye Alexa Fluor 555-albumin was applied to quantify osmotic water transport across the mouse peritoneal membrane resulting from modulating dialysate osmolality and genetic silencing of the water channel aquaporin-1 (AQP1). Quantification of osmotic water transport using Alexa Fluor 555-albumin closely correlated with direct volumetry and with estimations based on radioiodinated ((125)I) serum albumin (RISA). The low intraperitoneal pressure probably accounts for the negligible disappearance of the tracer from the peritoneal cavity in this model. Taken together, these data demonstrate the appropriateness of pH-insensitive Alexa Fluor 555-albumin as a practical and reliable intraperitoneal volume tracer to quantify osmotic water transport in vivo. Copyright © 2014 the American Physiological Society.

Quantification and characterization of enzymatically produced hyaluronan with fluorophore-assisted carbohydrate electrophoresis.

Science.gov (United States)

Kooy, Floor K; Ma, Muyuan; Beeftink, Hendrik H; Eggink, Gerrit; Tramper, Johannes; Boeriu, Carmen G

2009-01-15

Hyaluronan (HA) is a polysaccharide with high-potential medical applications, depending on the chain length and the chain length distribution. Special interest goes to homogeneous HA oligosaccharides, which can be enzymatically produced using Pasteurella multocida hyaluronan synthase (PmHAS). We have developed a sensitive, simple, and fast method, based on fluorophore-assisted carbohydrate electrophoresis (FACE), for characterization and quantification of polymerization products. A chromatographic pure fluorescent template was synthesized from HA tetrasaccharide (HA4) and 2-aminobenzoic acid. HA4-fluor and HA4 were used as template for PmHAS-mediated polymerization of nucleotide sugars. All products, fluorescent and nonfluorescent, were analyzed with gel electrophoresis and quantified using lane densitometry. Comparison of HA4- and HA4-fluor-derived polymers showed that the fluorophore did not negatively influence the PmHAS-mediated polymerization. Only even-numbered oligosaccharide products were observed using HA4-fluor or HA4 as template. The fluorophore intensity was linearly related to its concentration, and the limit of detection was determined to be 7.4pmol per product band. With this assay, we can now differentiate oligosaccharides of size range DP2 (degree of polymerization 2) to approximately DP400, monitor the progress of polymerization reactions, and measure subtle differences in polymerization rate. Quantifying polymerization products enables us to study the influence of experimental conditions on HA synthesis.

The efficiency of different disinfecting agents in inactivating microorganisms detected in natural and treated waters; Eficiencia de diferentes agentes desinfectantes en la inactivacion de microorganismos detectados en aguas naturales y tratadas

Energy Technology Data Exchange (ETDEWEB)

Perez Recuerda, R.; Sanchez, J.M.; Borrego, J.J.

1998-12-01

The efficiency of microbial inactivation and sublethal injury of six disinfectants (chlorine, chloramines, uV-light, potassium permanganate, fluor and ozone) applied at different dose on several bacterial strains, yeast and viruses has been studied comparatively. Disinfectant effect was higher on Gramnegative bacteria (Salmonella, Pseudomonas, Escherichia and Klebsiella) than on Gram-positive (Clostridium, Enterococcus and Stanphylococcus); although the least inactivation effect was obtained on the MS-2 bacteriophage. The global efficiency ranking of the disinfectants assayed to produce the microbial inactivation was as follows; ozone>chlorine>UV-light>chloramines>permanganate>fluor. On the other hand, on Escherichia coli and Pseudomonas aerugionosa were observed the highest sublethal injuries provokes by the disinfectants and dose assayed. Therefore, these microorganisms are the main candidates to regrow and to form biofilm in drinking water distribution systems. 34 refs. (Author)

Examination of vegetation around a nuclear plant emitting gaseous fluorides in order to detect fluorine pollution; Utilisation des vegetaux pour detecter la pollution fluoree autour d'une usine susceptible d'emettre des effluents gazeux fluores

Energy Technology Data Exchange (ETDEWEB)

Teulon, Francoise; Bonnaventure, J. P. [Commissariat a l' energie atomique et aux energies alternatives - CEA, Centre de Pierrelatte, Section de Protection contre les Radiations (France)

1971-08-15

Fluorine pollution (chronic or occasional) around a plant rejecting gaseous fluoride effluents can be detected from vegetation samples by chemical analysis. Systematic monitoring allows the effects and gravity of the pollution to be estimated. The analytical method used consists of a double distillation (in phosphoric acid and perchloric acid) followed by a spectro-colorimetric analysis (alizarine-complexon-lanthane). This method of control allows both the efficiency of the trapping installations and also the appearance of effluents at unexpected places to be checked, In the event of an accident it is possible to determine the advisability of prohibiting the consumption of locally grown produce by humans or fodder by cattle. Research conducted in order to determine the relation between visible, damage to certain vegetables (tomatoes, haricot beans and sorghum) and their fluorine contents demonstrated that such a relation appears above all at the level of the leaves; chemical analysis may thus be used to confirm or reject information obtained on the basis of visual evidence [French] La detection d'une pollution fluoree (chronique ou accidentelle) autour d'une usine susceptible d'emettre des effluents gazeux fluores peut etre avantageusement realisee par un reseau de prelevements vegetaux suivis de dosages chimiques. Une surveillance systematique permet une evaluation des consequences et du degre de gravite de la pollution. La methode d'analyse consiste en une double distillation (dans l'acide phosphorique et l'acide perchlorique) suivie d'une spectrocolorimetrie (alizarine-complexon-lanthane). Ce mode de controle permet non seulement de verifier si les installations de piegeage sont efficaces mais egalement de localiser des points d'emission imprevus. En cas d'accident, on peut egalement juger de l'opportunite d'interdire la consommation des legumes par les habitants ou du fourrage par le betail des environs. Enfin, des etudes experimentales ont ete realisees pour

Managing the process for storage and disposal of immobilized high- and low-level tank waste at the Hanford Site

International Nuclear Information System (INIS)

Murkowski, R.J.

1998-01-01

Lockheed Martin Hanford Corporation (LMHC) is one of six subcontractors under Fluor Daniel Hanford, Inc., the Management and Integration contractor for the Project Hanford Management Contract working for the US Department of Energy. One of LMHC's responsibilities is to prepare storage and disposal facilities to receive immobilized high and low-level tank waste by June of 2002. The immobilized materials are to be produced by one or more vendors working under a privatization contract. The immobilized low-activity waste is to be permanently disposed of at the Hanford Site while the immobilized high-level waste is to be stored at the Hanford Site while awaiting shipment to the offsite repository. Figure 1 is an overview of the entire cleanup mission with the disposal portion of the mission. Figure 2 is a representation of major activities required to complete the storage and disposal mission. The challenge for the LNIHC team is to understand and plan for accepting materials that are described in the Request for Proposal. Private companies will submit bids based on the Request for Proposal and other Department of Energy requirements. LMHC, however, must maintain sufficient flexibility to accept modifications that may occur during the privatization bid/award process that is expected to be completed by May 1998. Fundamental to this planning is to minimize the risks of stand-by costs if storage and disposal facilities are not available to receive the immobilized waste. LMHC has followed a rigorous process for the identification of the functions and requirements of the storage/disposal facilities. A set of alternatives to meet these functions and requirements were identified and evaluated. The alternatives selected were (1) to modify four vaults for disposal of immobilized low-activity waste, and (2) to retrofit a portion of the Canister Storage Building for storage of immobilized high-level waste

THE DEACTIVATION, DECONTAMINATION AND DECOMMISSIONING OF THE PLUTONIUM FINISHING PLANT, A FORMER PLUTONIUM PROCESSING FACILITY AT DOE'S HANFORD SITE

International Nuclear Information System (INIS)

CHARBONEAU, S.L.

2006-01-01

The Plutonium Finishing Plant (PFP) was constructed as part of the Manhattan Project during World War II. The Manhattan Project was developed to usher in the use of nuclear weapons to end the war. The primary mission of the PFP was to provide plutonium used as special nuclear material (SNM) for fabrication of nuclear devices for the war effort. Subsequent to the end of World War II, the PFP's mission expanded to support the Cold War effort through plutonium production during the nuclear arms race and later the processing of fuel grade mixed plutonium-uranium oxide to support DOE's breeder reactor program. In October 1990, at the close of the production mission for PFP, a shutdown order was prepared by the Department of Energy (DOE) in Washington,; DC--and issued to the Richland DOE field office. Subsequent to the shutdown order, a team from the Defense Nuclear Facilities Safety Board (DNFSB) analyzed the hazards at PFP associated with the continued storage of certain forms of plutonium solutions and solids. The assessment identified many discrete actions that were required to stabilize the different plutonium forms into stable form and repackage the material in high integrity containers. These actions were technically complicated and completed as part of the PFP nuclear material stabilization project between 1995 and early 2005. The completion of the stabilization project was a necessary first step in deactivating PFP. During stabilization, DOE entered into negotiations with the U.S. Environmental Protection Agency (EPA) and the State of Washington and established milestones for the Deactivation and Decommissioning (DandD) of the PFP. The DOE and its contractor, Fluor Hanford (Fluor), have made great progress in deactivating, decontaminating and decommissioning the PFP at the Hanford Site as detailed in this paper. Background information covering the PFP DandD effort includes descriptions of negotiations with the State of Washington concerning consent

Assessment of Chemical and Radiological Vulnerabilities

International Nuclear Information System (INIS)

SETH, S.S.

2000-01-01

Following the May 14, 1997 chemical explosion at Hanford's Plutonium Reclamation Facility, the Department of Energy Richland Operations Office and its prime contractor, Fluor Hanford, Inc., completed an extensive assessment to identify and address chemical and radiological safety vulnerabilities at all facilities under the Project Hanford Management Contract. This was a challenging undertaking because of the immense size of the problem, unique technical issues, and competing priorities. This paper focuses on the assessment process, including the criteria and methodology for data collection, evaluation, and risk-based scoring. It does not provide details on the facility-specific results and corrective actions, but discusses the approach taken to address the identified vulnerabilities

Effect of fluoride varnish on Streptococcus mutans counts in plaque of caries-free children using dentocult SM strip mutans test: A randomized controlled triple blind study

Directory of Open Access Journals (Sweden)

Jeevarathan J

2007-01-01

Full Text Available Dental caries is one of the most prevalent infectious diseases and although of multifactorial origin, Streptococcus mutans is considered the chief pathogen in its development. Fluoride is one of the most effective agents used for the reduction of dental caries apart from oral hygiene maintenance. Aims: The aim of this study was to estimate the counts of Streptococcus mutans and to evaluate the effect of Fluor Protector fluoride varnish on these counts in the plaque of caries-free children using Dentocult SM Strip Mutans. Materials and Methods: Thirty caries-free subjects were selected for the study based on the information obtained from a questionnaire and were randomly assigned to the control group consisting of ten subjects and the study group consisting of twenty subjects. Plaque samples were collected on the strips from the Dentocult SM kit and after incubation, the presence of Streptococcus mutans was evaluated using the manufacturer′s chart. The study group was subjected to a Fluor Protector fluoride varnish application following which the samples were collected again after 24 hours. Results: The average Streptococcus mutan s counts in the primary dentition of caries-free children before and after the application of Fluor Protector fluoride varnish were 10 4 -10 5 colony forming units (CFU/ml and < 10 4 CFU/ml respectively. Conclusion: The results showed that the study group had a statistically significant reduction in the plaque Streptococcus mutans counts than the control group.

Nanoscale control of Ag nanostructures for plasmonic fluorescence enhancement of near-infrared dyes

KAUST Repository

Xie, Fang; Pang, Jing S.; Centeno, Anthony; Ryan, Mary P.; Riley, D. Jason; Alford, Neil M.

2013-01-01

of increasing the sensitivity of protein detection in clinical applications. We report the use of tunable plasmonic silver nanostructures for the fluorescence enhancement of a near-infrared (NIR) dye (Alexa Fluor 790). Extensive fluorescence enhancement of ∼2

Tolerancing requirements for remote handling at the Hanford Waste Vitrification Plant

International Nuclear Information System (INIS)

Van Katwijk, C.; Keenan, R.M.; Bullis, R.E.

1993-01-01

The Hanford Waste Vitrification Plant (HWVP) is being designed by Fluor Daniel, Inc. with Waste Chem Corporation as Fluor Daniel, Inc.'s major subcontractor specializing in vitrification and remote system technologies. United Engineers and Constructors (UE ampersand C)/Catalytic (UCAT) will construct the plant. Westinghouse Hanford Company is the Project Integration manager and Business manager, and as the plant operator it provides technical direction to the Architect/ Engineer team (A/E) and constructor on behalf of the US Department of Energy - Richland Field Office. The A/E has developed, in cooperation with UE ampersand C, Westinghouse Hanford Company, and the US Department of Energy, a new and innovative approach to installations of the many remote nozzles and electrical connectors that must be installed to demanding tolerances. This paper summarizes the key elements of the HWVP approach

The Reactions of Hot Fluorine-18 with Gaseous Carbon Tetrafluoride; Reactions des Atomes {sup 18}F Chauds avec le Tetrafluorure de Carbone en Phase Gazeuse; Reaktsii goryachikh atomov ftora-18 s gazovoj fazoj tetraftormetana; Reacciones de Atomos Calientes de Fluor-18 con Tetrafluoruro de Carbono Gaseoso

Energy Technology Data Exchange (ETDEWEB)

Colebourne, N.; Todd, J. F.J.; Wolfgang, R. [Yale University, New Haven, CT (United States)

1965-04-15

Studies on the reactions of hot Fie atoms with carbon tetrafluoride are reported. Gaseous samples were exposed to the 40-60 MeV (maximum) bremsstrahlung beam of the Yale University Electron Accelerator. The F{sup 19} ({gamma}, n) F{sup 18} process produces F{sup 18} with a kinetic energy of the order of 10{sup 5}-10{sup 6} eV. These species lose energy by collision and are expected to reach the ''chemical'' energy range (< 100 eV) as ground state atoms. Ethylene was found to be a good scavenger for thermal F{sup 18} atoms. Analysis of products was made using standard radio-gas chromatography techniques. The system was found to be quite sensitive to extraneous radiation damage effects and appropriate precautions were taken. Hot displacement reactions, similar to those observed for hot hydrogen, but much less efficient, were found: F{sup 18} + CF{sup 4} --> CF{sub 3}F{sup 18} + F, F{sup 18} +CF{sub 4} --> CF{sub 2}F{sup 18} + (F + F), It was impossible to study the abstraction reaction F{sup 18} + CF{sub 4} --> CF{sub 3} + FF{sup 18} directly. However, indirect evidence suggests that it also has a low efficiency. Detailed studies of the effect of moderator on the F{sup 18} + CF{sub 4} system have been made. The data obtained were analysed by means of the kinetic theory of hot reactions. The system was found to be in accord with this formalism, providing quantitative confirmation of the present interpretation of the results. The carbon tetrafluoride and methane systems provide a basis for some tentative conclusions on the mechanisms of hot fluorine atom reactions. At present it appears that with certain important, but natural, modifications the model first developed for hot hydrogen atoms is applicable [French] Le memoire est consacre a des etudes sur les reactions des atomes {sup 18}F chauds avec le tetrafluorure de carbone. Des echantillons gazeux ont ete exposes a un faisceau de rayonnements de freinage de 40 a 60 MeV (maximum) emis par l'accelerateur d

Decay Of Bacterial Pathogen, Fecal Indicators, And Real-Time Quantitative PCR Genetic Markers In Manure Amended Soils

Science.gov (United States)

This study examined persistence and decay of bacterial pathogens, fecal indicator bacteria, and emerging real-time quantitative PCR (qPCR) genetic markers for rapid detection of fecal pollution in manre-amended agricultural soils. Known concentrations of transformed green fluore...

CSER 99-002: CSER for unrestricted moderation of sludge material with two-boat operations in gloveboxes HC-21A and HC-21C

International Nuclear Information System (INIS)

LAN, J.S.

1999-01-01

This Criticality Safety Evaluation Report was prepared by Fluor Daniel Northwest under contract to BWHC. This document establishes the criticality safety parameters for unrestricted moderation of Sludge material with two-boat operations in gloveboxes HC-21A and HC-21C

Environmental Management Performance Report July 2000

Energy Technology Data Exchange (ETDEWEB)

EDER, D.M.

2000-07-01

The purpose of this report is to provide the Department of Energy Richland Operations Office (DOE-RL) a monthly summary of the Project Hanford Management Contractor's (PHMC) Environmental Management (EM) performance by Fluor Hanford (FH) and its subcont.

Early postnatal exposure to lithium in vitro induces changes in ...

Indian Academy of Sciences (India)

treated cultures. Rate of dye loss from vesicles is influenced by the extent of .... Recyc-II-loaded boutons in lithium-treated cultures show significant enhancement in fluores- cence and ... replaced with media containing either 2 μM H-89 (for.

FFTF Authorization Agreement

International Nuclear Information System (INIS)

DAUTEL, W.A.

2000-01-01

The purpose of the Authorization Agreement is to serve as a mechanism whereby the U.S. Department of Energy, Richland Operations Office (RL) and Fluor Hanford (FH) jointly clarify and agree to key conditions for conducting work safely and efficiently

A novel analytical method for in vivo phosphate tracking (Corrigendum in FEBS Letters, 2007, 581 p. 579)

DEFF Research Database (Denmark)

Gu, H.; Lalonde, S.; Okumoto, S.

2006-01-01

Genetically-encoded fluorescence resonance energy transfer (FRET) sensors for phosphate (Pi) (FLIPPi) were engineered by fusing a predicted Synechococcus phosphate-binding protein (PiBP) to eCFP and Venus. Purified fluorescent indicator protein for inorganic phosphate (FLIPPi), in which the fluor...

77 FR 50102 - Application for Final Commitment for a Long-Term Loan or Financial Guarantee in Excess of $100...

Science.gov (United States)

2012-08-20

... support the export of U.S. services and equipment to Saudi Arabia. Brief non-proprietary description of... Incorporated; Jacobs Engineering Group Incorporated; Foster Wheeler AG; Fluor Corporation. Obligor: The obligor... Being Exported The items being exported are design work, construction services, technology licenses...

LESSONS LEARNED IN OPERATING THE HOSE-IN-HOSE SYSTEM FOR TRANSFSERRING SLUDGE AT HANFORD'S K BASINS

International Nuclear Information System (INIS)

PERES MW

2008-01-01

In May 2007, the Department of Energy and the Fluor Hanford K Basin Closure Project completed transferring sludge from the K East Basin to new containers in the K West Basin using a Hose-in-Hose system. This project presented a number of complex and unique technical, operational, and management challenges that had to be resolved to complete the required transfers and satisfy project milestones. The project team (including DOE; regulators; and Fluor management, operations, maintenance, engineering and all other support organizations) found innovative solutions to each challenge. This paper records lessons learned during the operational phase of the sludge transfer via the Hose-In-Hose system. The subject is limited to the operational phase and does not cover design, development, testing or turnover. A discussion of the situation or problem encountered is provided, along with the lesson learned as applicable to a future program or project

Clinical evaluation of high dose rate intra-cavitary irradiation for treatment of uterine cervical cancer, combined with pepleomycin suppository in uterine cavity

International Nuclear Information System (INIS)

Yamanashi, Shunji; Abe, Tatsuyuki; Mochizuki, Sachio; Murakami, Yoshitaka; Iida, Nobuhisa.

1990-01-01

By means of re-irradiation using pepleomycin suppository in uterine cavity, we attained local control for one patient who had local recurrence in uterine cavity and suffered from uterine fluor in which viable cancer cells were confirmed. We were enlightened by this therapeutic experience, so we attempted combination therapy using pepleomycin suppositories to supplement intra-cavitary irradiation, for the 11 selected patients who were suffering from uterine fluor. We investigated the treatment results in 7 patients of stage III out of 11 patients (of all stages), in comparison with 13 patients of stage III who were treated by irradiation alone. Consequently, these treatment results were approximately equivalent, and the incidence of sigmoid complications could be decreased. Side effects which were followed by the combination therapy were not serious, and so we believe that pepleomycin suppository is a simple method and valuable to supplement radiation therapy of uterine cervical cancer. (author)

Clinical evaluation of high dose rate intra-cavitary irradiation for treatment of uterine cervical cancer, combined with pepleomycin suppository in uterine cavity

Energy Technology Data Exchange (ETDEWEB)

Yamanashi, Shunji; Abe, Tatsuyuki; Mochizuki, Sachio (Jikei Univ., Tokyo (Japan). School of Medicine); Murakami, Yoshitaka; Iida, Nobuhisa

1990-02-01

By means of re-irradiation using pepleomycin suppository in uterine cavity, we attained local control for one patient who had local recurrence in uterine cavity and suffered from uterine fluor in which viable cancer cells were confirmed. We were enlightened by this therapeutic experience, so we attempted combination therapy using pepleomycin suppositories to supplement intra-cavitary irradiation, for the 11 selected patients who were suffering from uterine fluor. We investigated the treatment results in 7 patients of stage III out of 11 patients (of all stages), in comparison with 13 patients of stage III who were treated by irradiation alone. Consequently, these treatment results were approximately equivalent, and the incidence of sigmoid complications could be decreased. Side effects which were followed by the combination therapy were not serious, and so we believe that pepleomycin suppository is a simple method and valuable to supplement radiation therapy of uterine cervical cancer. (author).

Installation and routing of critical embedments at the Hanford Waste Vitrification Plant

International Nuclear Information System (INIS)

Van Katwijk, C.; Keenan, R.M.; Watts, C.

1993-01-01

The Hanford Waste Vitrification Plant (HWVP) is being designed by Fluor Daniel. Waste Chem Corporation is providing specialized expertise as Fluor Daniel's major subcontractor for vitrification and remote systems technologies. Westinghouse Hanford Company (Westinghouse Hanford) is the Project Integration manager and Business manager, and as the plant operator it provides technical direction to the Architect/Engineer team and constructor on behalf of the US Department of Energy, Richland Field Office. The Hot Cell portion of HWVP Vitrification Building contains very congested piping systems in the walls that penetrate in to the cells to nozzles for remote piping jumper assemblies. These nozzles require very tight tolerances to ensure a leak-tight fit to the jumpers. An approach has been developed that minimizes the time and expense of installing these nozzles in the wall to tight construction tolerances. This approach is called the Ganged Embed Plate (GEP) design

Fuel cycle of nuclear power plants and safeguards system of nuclear weapon nonproliferation

International Nuclear Information System (INIS)

Malek, Z.

1980-10-01

The international safeguard system of nuclear weapon nonproliferation and the IAEA safeguard system are briefly described. In Czechoslovakia, a decree was issued in 1977 governing the accounting for and control of nuclear materials. The contents of the decree are presented. Described are computer processing of accounting data, technical criteria for the safeguard system application, containment and inspection in the IAEA safeguard system. The method is shown of the control of and accounting for nuclear materials in nuclear power plants and in fuel manufacturing, reprocessing and enrichment plants. Nondestructive and destructive methods of nuclear materials analysis are discussed. Nondestructive methods used include gamma spectrometry, neutron techniques, X-ray fluores--cence techniques. (J.P.)

PNNL Apatite Investigation at 100-NR-2 Quality Assurance Project Plan

Energy Technology Data Exchange (ETDEWEB)

Fix, N. J.

2009-04-02

In 2004, the U.S. Department of Energy, Fluor Hanford, Inc., Pacific Northwest National Laboratory (PNNL), and the Washington Department of Ecology agreed that the long-term strategy for groundwater remediation at the 100-N Area would include apatite sequestration as the primary treatment, followed by a secondary treatment if necessary. Since then, the agencies have worked together to agree on which apatite sequestration technology has the greatest chance of reducing strontium-90 flux to the Columbia River. This Quality Assurance Project Plan provides the quality assurance requirements and processes that will be followed by staff working on the PNNL Apatite Investigation at 100-NR-2 Project. The plan is designed to be used exclusively by project staff.

Polysiloxane scintillator composition

Science.gov (United States)

Walker, J.K.

1992-05-05

A plastic scintillator useful for detecting ionizing radiation comprising a matrix which comprises an optically transparent polysiloxane having incorporated therein at least one ionizing radiation-hard fluor capable of converting electromagnetic energy produced in the polysiloxane upon absorption of ionizing radiation to detectable light.

HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger

DEFF Research Database (Denmark)

Andersen, Aaron John Christian; Soman De Medeiros, Lívia; Binzer, Sofie Bjørnholt

2017-01-01

L). The standard was quantified by fluorescent derivatisation using Waters AccQ-Fluor reagent and derivatised fumonisin B₁ and fumonisin B₂ as standards, as each contain a primary amine. Various sample preparation methods for whole culture samples were assessed, including six different solid phase...

Penetration of varnishes into demineralized root dentine in vitro

NARCIS (Netherlands)

Arends, J; Duschner, H; Ruben, JL

1997-01-01

In this paper the penetration of three different varnishes employed in caries prevention (Duraphat(R), Fluor Protector(R) and Cervitec(R)) into demineralized dentine is quantified using confocal laser scanning microscopy. The results show that the varnish penetration into lesions about 85 mu m in

Comparison of two bond strength testing methodologies for bilayered all-ceramics

NARCIS (Netherlands)

Dundar, Mine; Ozcan, Mutlu; Gokce, Bulent; Comlekoglu, Erhan; Leite, Fabiola; Valandro, Luiz Felipe

Objectives. This study compared the shear bond strength (SBS) and microtensile (MTBS) testing methodologies for core and veneering ceramics in four types of all-ceramic systems. Methods. Four different ceramic veneer/core combinations, three of which were feldspathic and the other a fluor-apatite to

Technical Note: Characteristics and Sorting of White Food Corn Contaminated with Mycotoxins

Science.gov (United States)

Samples of white corn grown in southern Texas were collected for characterization and sorting of kernels containing mycotoxins. Kernels were grouped into one of six symptom categories depending on the degree of visible discoloration and bright green-yellow fluorescence (BGYF) or bright orange fluor...

The treatment of large quantities of high fluorin contents UO2 by ammonium double uranate (ADU) techniques

International Nuclear Information System (INIS)

Wang Bangwu; Chen Ying

2010-01-01

The paper has discussed the sinter action of UO 2 in low temperature. The study indicates the over hot part of UO 2 by the deoxidization hot of oxidation uranate mostly results in the sinter in the process of trans form ADU into UO 2 . The UO 2 settling times in kiln little influences the sinter performance of UO 2 in the same condition of high fluorin contents UO 2 returning kiln, and high fluorin contents UO 2 returning kiln does not sinter UO 2 again. Experiment on large quantities of high fluorin contents UO 2 by Ammonium Double Uranate (ADU) techniques direct returning kiln, the result shows the sinter performance of UO 2 doesn't drop in the process of high fluor in contents UO 2 direct returning kiln, and the performance of UO 2 can meet specification. (authors)

Effect of a chlorhexidine/thymol and a fluoride varnish on caries development in erupting permanent molars

DEFF Research Database (Denmark)

Flamee, S; Gizani, S; Caroni, C

2015-01-01

(Fluor Protector; FV group). The duration of the study was 2 years. The primary endpoint was caries incidence (initial and cavitated) in the erupting molars and the secondary outcome was salivary mutans streptococci (MS) counts. RESULTS: The groups were balanced with respect to socio-economy, oral...

A Fluorescent Assay for Plant Caffeic Acid O-methyltransferases

Science.gov (United States)

We have developed a facile, sensitive and continuous assay to measure the activities of plant COMTs using s-adenosyl homocysteine hydrolase as a coupling enzyme and and adeonsine a thiol-specific fluor, Thioglo1, as the detecting reagent. This assay was validated using recombinant sorghum COMT (BMR-...

Quantitative estimation of the fluorescent parameters for crop leaves with the Bayesian inversion

Science.gov (United States)

In this study, the fluorescent parameters of crop leaves were retrieved from the leaf hyperspectral measurements by inverting the FluorMODleaf model, which is a leaf-level fluorescence model that is based on the widely used and validated PROSPECT (leaf optical properties) model and can simulate the ...

[In vivo retention of KOH soluble and firmly bound fluoride in demineralized dental enamel].

Science.gov (United States)

Hellwig, E; Klimek, J; Albert, G

1989-03-01

Cylindrical enamel blocks with initial carious lesions were treated for one hour with Duraphat or Fluor-Protector. After removal of the fluoride varnishes the enamel blocks were kept in the mouths of 3 probands for 5 days. Plaque was allowed to accumulate on half of the enamel cylinders, while the other half was kept clean. Part of the enamel cylinders were retained as fluoridated controls. Compared with Duraphat the application of Fluor-Protector resulted in a significantly higher uptake of KOH soluble and firmly bound fluoride. During the 5 days of the experiment the amount of KOH soluble fluorides decreased in both groups. In the presence of plaque the fluoride loss was higher. The amount of firmly bound fluoride increased both in the plaque covered and in the clean enamel. The durable cariostatic effect of fluoridated varnishes seems to be due to the slow dissolution of Ca F2-like precipitates on the enamel surface and the concomitant fluoride uptake in the underlying demineralized enamel.

NIR FRET Fluorophores for Use as an Implantable Glucose Biosensor

Directory of Open Access Journals (Sweden)

Majed DWEIK

2008-12-01

Full Text Available Development of an in vivo optical sensor requires the utilization of Near Infra Red (NIR fluorophores due to their ability to operate within the biological tissue window. Alexa Fluor 750 (AF750 and Alexa Fluor 680 (AF680 were examined as potential NIR fluorophores for an in vivo fluorescence resonance energy transfer (FRET glucose biosensor. AF680 and AF750 found to be a FRET pair and percent energy transfer was calculated. Next, the tested dye pair was utilized in a competitive binding assay in order to detect glucose. Concanavalin A (Con A and dextran have binding affinity, but in the presence of glucose, glucose displaces dextran due to its higher affinity to Con A than dextran. Finally, the percent signal transfer through porcine skin was examined. The results showed with approximately 4.0 mm porcine skin thickness, 1.98 % of the fluorescence was transmitted and captured by the detector.

Glucose Binding Protein as a Novel Optical Glucose Nanobiosensor

Directory of Open Access Journals (Sweden)

Majed DWEIK

2009-11-01

Full Text Available Development of an in vivo optical sensor requires the utilization of Near Infra Red (NIR fluorophores due to their ability to operate within the biological tissue window. Alexa Fluor 750 (AF750 and Alexa Fluor 680 (AF680 were examined as potential NIR fluorophores for an in vivo fluorescence resonance energy transfer (FRET glucose biosensor. AF680 and AF750 found to be a FRET pair and percent energy transfer was calculated. Next, the tested dye pair was utilized in a competitive binding assay in order to detect glucose. Concanavalin A (Con A and dextran have binding affinity, but in the presence of glucose, glucose displaces dextran due to its higher affinity to Con A than dextran. Finally, the percent signal transfer through porcine skin was examined. The results showed with approximately 4.0 mm porcine skin thickness, 1.98 % of the fluorescence was transmitted and captured by the detector.

Nonclassical polarization effects in fluorescence emission spectra from microdroplets

Science.gov (United States)

Arnold, S.; Goddard, N. L.; Hill, S. C.

1999-12-01

We report a pronounced nonclassical polarization effect on the shape of fluorescence emission spectra from isolated microdroplets containing a dilute solution of soluble fluors or a dilute layer of surfactant fluors. We see different spectral shapes for 90° scattering when comparing between IVV, IVH, IHH, IHV. However, we measure the largest difference in spectral shape in the surfactant case, with the incident polarization directed toward the detector (IHV vs IHH). Imaging reveals that the emission in this case principally arises from two distinct regions near the surface of the droplet, which are diametrically opposed and along the axis of the incident laser beam. The effect appears to be the direct result of coupling between molecular emission moments and electromagnetic modes of the droplet. It is not the molecule which radiates but the molecule microvessel. Directional emission is sensitive to the polarization of the electromagnetic mode which is stimulated by the coupling.

SGN-Reseau Eurisys participates to the Hanford military site rehabilitation

International Nuclear Information System (INIS)

Anon.

1996-01-01

Numatec Hanford Corporation, a subsidiary company of SGN-Reseau Eurisys and Cogema, gained with Fluor Daniel the contract for the rehabilitation of the old military nuclear centre of Hanford (Washington, USA). This contract of 5 years represents 5 billions of US dollars with 300 millions of dollars for the French part. This short paper gives a general description of the Hanford installations and of the partners involved in the contract: Fluor Daniel consortium, Lockheed Martin, Babcock and Wilcox, Duke Engineering and Services, Rust Federal Services, Numatec Hanford Corporation (NHC), SGN-Eurisys Services Corporation (SESC). The schedule comprises: the stabilisation of the residual plutonium in all installations before December 1999, the removal of muds and debris from the K storage pool of irradiated fuels before June 2000, the draining and cleaning of the high activity storage tanks before December 2001 and the general decontamination of the installations up to the year 2005. (J.S.)

AIR PERMIT COMPLIANCE FOR WASTE RETRIEVAL OEPRATIONS INVOLVING MULTI-UNIT EMISSIONS

International Nuclear Information System (INIS)

SIMMONS FM

2007-01-01

Since 1970, approximately 38,000 suspect-transuranic and transuranic waste containers have been placed in retrievable storage on the Hanford Site in the 200 Areas burial grounds. Hanford's Waste Retrieval Project is retrieving these buried containers and processing them for safe storage and disposition. Container retrieval activities require an air emissions permit to account for potential emissions of radionuclides. The air permit covers the excavation activities as well as activities associated with assaying containers and installing filters in the retrieved transuranic containers lacking proper venting devices. Fluor Hanford, Inc. is required to track radioactive emissions resulting from the retrieval activities. Air, soil, and debris media contribute to the emissions and enabling assumptions allow for calculation of emissions. Each of these activities is limited to an allowed annual emission (per calendar year) and .contributes to the overall total emissions allowed for waste retrieval operations. Tracking these emissions is required to ensure a permit exceedance does not occur. A tracking tool was developed to calculate potential emissions in real time sense. Logic evaluations are established within the tracking system to compare real time data against license limits to ensure values are not exceeded for either an individual activity or the total limit. Data input are based on field survey and workplace air monitoring activities. This tracking tool is used monthly and quarterly to verify compliance to the license limits. Use of this tool has allowed Fluor Hanford, Inc. to successfully retrieve a significant number of containers in a safe manner without any exceedance of emission limits

Fluor determination by alkaline hydrolysis of the uranium and thorium fluorides; Determinacion de fluor por hidrolisis alcalina en fluoruros de uranio y torio

Energy Technology Data Exchange (ETDEWEB)

Barrachina Gomez, L; Gasco Sanchez, L

1961-07-01

The alkaline hydrolysis of the uranium and thorium fluorides is studded and a new method for the determination of the fluoride, on the basis of a indirect volumetric titration with standard soda, is proposed. The compounds that may influence the hydrolysis of the uranium fluoride and that may be occasionally found in it as impurities are also studied. the method can be applied to the uranium fluoride except when there is a great quantity of F{sub 2}UO{sub 2} or UO{sub 3} present in the sample. (Author) 20 refs.

A novel quantitative light‑induced fluorescence device for monitoring ...

African Journals Online (AJOL)

2015-08-06

Aug 6, 2015 ... Background: The FluoreCam system is based on an innovative approach to the ... In total, 11 patients with MIH were diagnosed on a visual MIH scale and ... sensitivity and specificity over traditional techniques .... clinician to record the subject's identification, date of visit, ... versus unaffected enamel.

40 CFR 82.19 - Apportionment of baseline consumption allowances for class II controlled substances.

Science.gov (United States)

2010-07-01

... allowances for class II controlled substances. 82.19 Section 82.19 Protection of Environment ENVIRONMENTAL... Consumption Controls § 82.19 Apportionment of baseline consumption allowances for class II controlled... Ineos Fluor Americas HCFC-22 2,546,305 Kivlan & Company HCFC-22 2,081,018 MDA Manufacturing HCFC-22 2...

Neutron Scattering for Materials Science. Materials Research Society Symposium Proceedings, Volume 166

Science.gov (United States)

1990-01-01

technique - with experimentally produced quartz and calcite textures and the texture of a fluor-apatite sample from a dinosaur bone. Figure 1. Schematic...Lett. 58, 2718 (1987). 6. J. W. Cahn, J. Chem. Phys. 42, 93 (1965). 7. W. Haller, in Solid Phase Biochemistry - Analytical and Chemical Aspects

Synthetic immunostimulatory glycans interference with host cell apoptosis upon of Toxoplasma gondii infection, in vitro

Directory of Open Access Journals (Sweden)

S.H. Eassa

2017-06-01

Full Text Available Toxoplasmosis is a protozoan infection of humans and animals caused by Toxoplasma gondii, and it’s continuous public health and food safety issue. The tachyzoites (Tg of T. gondii are the most important stage, as they come in direct contact with immune cells such as a macrophage. Tg can modulate and prevent apoptosis of immune cells while promoting survival of the pathogen. Infections caused by Tg can be eradicated if immune cells could stimulate apoptosis and kill pathogens upon exposure. Apoptosis is characterized by the release of mediators, namely Caspases (Cas. New means are required for inducing apoptosis and enhance immunity in the infected host cell to control toxoplasmosis. The present study investigated whether Synthetic Immuno-stimulatory Glycans (SIGs influence Cas and Nitric oxide (NO release and led to Tg damage. Galβ1-3Gal-PAA-fluor (SIG1, Fucα1-4GlcNAcβ-PAA-fluor (SIG2 and GlcNAcβ1-3GalNAcα-PAA-fluor (SIG3 constituted samples studied principally. Murine macrophage had been exposed to the Tg then the SIGs effects on Cas and NO production were determined after 20 hours of pathogen phagocytosis. Here we report that the SIGs had potent in vitro activity against T. gondii; SIG2 was more effective than SIG1 and SIG3, representative by SIG2 treated infected macrophages can induced infected macrophages to release Cas1, 3, and 9. Maximum production of NO by infected macrophages was noticed following the expoxure to all SIGs. Therefore the present study provided the method for the selection of SIGs ligands bearing immunostimulatory factor and apoptotic stimuli properties.

The effects of the combination of chlorhexidine/thymol- and fluoride-containing varnishes on the severity of root caries lesions in frail institutionalised elderly people.

Science.gov (United States)

Brailsford, S R; Fiske, J; Gilbert, S; Clark, D; Beighton, D

2002-01-01

To compare the clinical effects of a fluoride-containing varnish (Fluor-Protector) in combination with a chlorhexidine-containing varnish (Cervitec) on existing root caries lesions in a group of frail elderly subjects. A randomised double blind longitudinal study was utilised. Subjects (n = 102) were randomly allocated to a Test or Placebo group. All leathery and soft root caries lesions in all subjects were coated with Fluor-Protector while the lesions in the Test group were also coated with Cervitec and the lesions in the Placebo group were coated with a Placebo varnish. Treatments were repeated five times in a 12-month period. Clinical parameters associated with root caries, measurements of individual lesions and salivary levels of caries associated bacteria were made at intervals. The clinical severity of the lesions in the Test group did not change significantly during the 12-month study period. In the Placebo group the mean lesion width and lesion height and length of exposed root increased significantly and the lesions were significantly closer to the gingival margin. There were no significant changes in the salivary levels of caries-associated microorganisms after 12 months although, in both groups, there was initially a significant reduction in the salivary levels of mutans streptococci. The combination of Fluor-Protector and Cervitec is a useful, simple, quick and non-invasive method for the control and management of existing root caries lesions. The procedure could be performed by a dental hygienist and may be usefully applied in other high-risk groups including persons with Parkinson's disease, debilitating neuromuscular conditions and dry mouth from whatever cause. Copyright 2002 Elsevier Science Ltd.

Characterization of damaging in apatitic materials irradiated with heavy ions and thermally annealed

International Nuclear Information System (INIS)

Tisserand, R.

2004-12-01

Some minerals belonging to the family of apatite are seen to be potential candidates for use as conditioning matrices or transmutation targets for high level nuclear waste management. Indeed, studies of natural nuclear reactors (Oklo) highlighted the strong ability of these minerals to anneal irradiation damage. In order to determine the global behaviour of these materials, we performed a fundamental study on the evolution of irradiation damage induced by various heavy ions in two apatites: a natural phospho-calcic fluor-apatite from Durango and a synthetic sintered mono-silicated fluor-apatite, called britholite. The damage in these materials was measured by using channelling R.B.S. and X-ray diffraction respectively and by determining an amorphization effective radius Re. The results revealed a similar behaviour for both apatites according to the electronic energy deposit at the entrance of the material. In addition, the effect of an isothermal annealing at 300 C was quantified on a mono-silicated britholite previously irradiated with Kr ions. We highlighted in this case the return of the lattice parameters to their initial values, followed by a partial and slow rebuilding of the crystalline lattice versus the annealing time. Finally, we followed the changes in the morphology of etch pits in the Durango fluor-apatite after acid dissolution as a function of the energy deposit by the ions. We showed that the influence of crystallography leads quickly to opening angles close to 30 degrees. The calculation of etching velocities within the irradiated material highlighted that there is a range of deposit energy where the velocity ratio increases strongly before becoming constant. (author)

Efficacy of reduced doses of bentazone assessed by instruments based on measurement of chlorophyll fluorescence

Directory of Open Access Journals (Sweden)

Vojtěch Kocurek

2011-01-01

Full Text Available Chlorophyll fluorescence is a type of radiation emitted by plants as unused part of energy absorbed from sunlight. Its intensity depends on many stress factors, nutrition, weather conditions etc. Methods based on chlorophyll fluorescence measurement have potential to be perspective for the assessment of herbicide efficacy, phytotoxicity or stress influence. Two fluorometers (FluorCam and handy FluorPen were used for measurements in laboratory experiments in 2007–2009. Herbicide Basagran super with active ingredient bentazone (480 g.l−1 was tested using a parameter called ‚Quantum yield of fluorescence‘ (QY in three different doses: the registered dose 2.0 l.ha−1 (100% and lower doses 1.5 l.ha−1 (75% and 1.0 l.ha−1 (50%. Treated experimental plants of redroot pigweed (Amaranthus retroflexus L. were measured in 0, 1, 2, 3, 6, 9 and 15 days after treatment and the results were compared with subjective assessment (estimation and growth parameters. The obtained results showed that the effect of bentazone measured by both devices was statistically significantly different from untreated control. We can also detect herbicide effect earlier by QY measurement than by other methods. Different doses showed significant differences 15 days after treatment for dose 2.0 l.ha−1 in comparison with both reduced doses. The subjective assessment showed significant differences in all terms of measurement (1–15 days after application except of the day of application. Regeneration of plants for which the youngest leaves were not treated by herbicide was observed for all doses. Difference of QY values between used devices was on average 0.119 (higher for FluorCam but statistically insignificant.

Integrated Environment and Safety and Health Management System (ISMS) Implementation Project Plan

Energy Technology Data Exchange (ETDEWEB)

MITCHELL, R.L.

2000-01-10

The Integrated Environment, Safety and Health Management System (ISMS) Implementation Project Plan serves as the project document to guide the Fluor Hanford, Inc (FHI) and Major Subcontractor (MSC) participants through the steps necessary to complete the integration of environment, safety, and health into management and work practices at all levels.

Integrated Environment and Safety and Health Management System (ISMS) Implementation Project Plan

International Nuclear Information System (INIS)

MITCHELL, R.L.

2000-01-01

The Integrated Environment, Safety and Health Management System (ISMS) Implementation Project Plan serves as the project document to guide the Fluor Hanford, Inc (FHI) and Major Subcontractor (MSC) participants through the steps necessary to complete the integration of environment, safety, and health into management and work practices at all levels

River Protection Project Integrated safety management system phase II verification review plan - 7/29/99

International Nuclear Information System (INIS)

SHOOP, D.S.

1999-01-01

The purpose of this review is to verify the implementation status of the Integrated Safety Management System (ISMS) for the River Protection Project (RPP) facilities managed by Fluor Daniel Hanford, Inc. (FDH) and operated by Lockheed Martin Hanford Company (LMHC). This review will also ascertain whether within RPP facilities and operations the work planning and execution processes are in place and functioning to effectively protect the health and safety of the workers, public, environment, and federal property over the RPP life cycle. The RPP ISMS should support the Hanford Strategic Plan (DOERL-96-92) to safely clean up and manage the site's legacy waste and deploy science and technology while incorporating the ISMS central theme to ''Do work safely'' and protect human health and the environment

Total cross-section measurements on aluminium, carbon, fluorine and hydrogen for d, d reaction neutrons using the coincidence method (1963); Mesure de la section efficace totale de l'aluminium, du carbone, du fluor et de l'hydrogene pour des neutrons de la reaction d, d par la methode des coincidences (1963)

Energy Technology Data Exchange (ETDEWEB)

Ambrosino, G; Sorriaux, A [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

The experiment described consists in the measurement of the total cross-section of various materials: aluminium, carbon, fluorine and hydrogen, for mono-energetic 2.77 MeV neutrons obtained from the d,d reaction. The measurement is carried out by transmission. The neutrons are detected by means of a plastic scintillator mounted on a 56 AVP photomultiplier, and are isolated from all secondary phenomena (background noise, scattered neutrons) by coincidence with helium 3. which particles are associated to the neutrons from the reaction {sup 2}{sub 1}D ({sup 2}{sub 1}D, n) {sup 3}{sub 2}H The helium 3 particles are detected by a PN junction diode used with inverted polarisation. An absorption exponential has been traced out using measurements made on seven aluminium bars. The accuracy of the total cross-section measurements is about 10{sup -2}. (authors) [French] L'experience exposee dans ce rapport consiste en la mesure des sections efficaces totales de differents materiaux: aluminium, carbone, fluor et hydrogene, pour des neutrons monoenergetiques de 2,77 MeV, obtenus par la reaction d,d. La mesure est faite par transmission. Les neutrons sont detectes par un scintillateur plastique monte sur un photomultiplicateur 56 AVP, et sont separes de tout phenomene secondaire (bruit de fond, neutrons diffuses) par coincidence avec les helium 3, particules associees aux neutrons de la reaction {sup 2}{sub 1}D ({sup 2}{sub 1}D, n) {sup 3}{sub 2}H Les helium 3 sont detectes par une diode a jonction PN utilisee en polarisation inverse. Une exponentielle d'absorption a ete tracee a partir de mesures faites sur sept barreaux d'aluminium. La precision des mesures des sections efficaces totales est de l'ordre de 10{sup -2}. (auteurs)

Five different colours solid-state fluorescence of azastilbenes: a new ...

Indian Academy of Sciences (India)

effect of dipolar intermolecular interactions on their fluorescence properties, the results revealed that the emission spectra of 1−5 in ... lasers,1 fluores- cence sensors,2 fluorescent technology,3 nonlinear optics,4 ..... Royal Golden Jubilee Ph.D. Program (Grant no. ... Derrar S N, Sekkal-Rahal M, Guemra K and Derreumaux P.

Faktor - Faktor yang Berhubungan dengan Derajat Kaparahan Karies di Kecamatan Slawi Kabupaten Tegal Propinsi Jawa Tengah Tahun 1998

Directory of Open Access Journals (Sweden)

Febrina Setiawati

2015-10-01

Full Text Available Residence of Slawi Subdistrict, Tegal District Central Java Province have a frequent tea drinking habit with specific characters of high concentrate tea without sugar or a lot of sugar. It is acknowledged that fluor content in tea can prevent dental caries, while sugar, a sucrose type of carbohydrate in the tea is most cariogenic. The subject of the study, regarding the tea drinking habit, is to obtain information about factors correlated to severity of dental caries in residence of the Slawi Subdistrict, Tegal Distric, Central Java Province. The study type is cross sectional with a sample size of 140. The subjects of the study were residents of Slawi Subdistric with age ranging from 18 to 44 years. An interview was conducted to obtain information of tea drinking characteristics. Samples of tea, water and sugar from each subject examined in a laboratory to obtain the information about fluor and and sugar contents in tea. Saliva examination was also conducted to know its buffer capacity and flow rate. Intra oral clinical examination was conducted to obtain DMF-T and plaque scores. Statistical analysis was applied with multiple linear regression methods using SPSS 7.5 and Stata version 4. The result of the study show that caries prevalence of 76.92% in subjects with tea drinking habit without sugar. The subjects had a 2.85 DMF-T score. Meanwhile caries prevalence was 98.15% for subjects with tea drinking habit with sugar. The subjects had a 6.15 DMF-T score. The mean of fluor concentration in all subjects drinking water was 0.11 mg/l, and 5.26% for sugar content. 68.94% of DMF-T score variation concluded in the multiple linear regression model, is showed by the factors in the model.

1998 interim 242-A Evaporator tank system integrity assessment report

Energy Technology Data Exchange (ETDEWEB)

Jensen, C.E.

1998-07-02

This Integrity Assessment Report (IAR) is prepared by Fluor Daniel Northwest (FDNW) under contract to Lockheed-Martin Hanford Company (LMHC) for Waste Management Hanford (WMH), the 242-A Evaporator (facility) operations contractor for Fluor Daniel Hanford, and the US Department of Energy, the system owner. The contract specifies that FDNW perform an interim (5 year) integrity assessment of the facility and prepare a written IAR in accordance with Washington Administrative Code (WAC) 173-303-640. The WAC 173-303 defines a treatment, storage, or disposal (TSD) facility tank system as the ``dangerous waste storage or treatment tank and its ancillary equipment and containment.`` This integrity assessment evaluates the two tank systems at the facility: the evaporator vessel, C-A-1 (also called the vapor-liquid separator), and the condensate collection tank, TK-C-100. This IAR evaluates the 242-A facility tank systems up to, but not including, the last valve or flanged connection inside the facility perimeter. The initial integrity assessment performed on the facility evaluated certain subsystems not directly in contact with dangerous waste, such as the steam condensate and used raw water subsystems, to provide technical information. These subsystems were not evaluated in this IAR. The last major upgrade to the facility was project B-534. The facility modifications, as a result of project B-534, were evaluated in the 1993 facility interim integrity assessment. Since that time, the following upgrades have occurred in the facility: installation of a process condensate recycle system, and installation of a package steam boiler to provide steam for the facility. The package boiler is not within the scope of the facility TSD.

1998 interim 242-A Evaporator tank system integrity assessment report

International Nuclear Information System (INIS)

Jensen, C.E.

1998-01-01

This Integrity Assessment Report (IAR) is prepared by Fluor Daniel Northwest (FDNW) under contract to Lockheed-Martin Hanford Company (LMHC) for Waste Management Hanford (WMH), the 242-A Evaporator (facility) operations contractor for Fluor Daniel Hanford, and the US Department of Energy, the system owner. The contract specifies that FDNW perform an interim (5 year) integrity assessment of the facility and prepare a written IAR in accordance with Washington Administrative Code (WAC) 173-303-640. The WAC 173-303 defines a treatment, storage, or disposal (TSD) facility tank system as the ''dangerous waste storage or treatment tank and its ancillary equipment and containment.'' This integrity assessment evaluates the two tank systems at the facility: the evaporator vessel, C-A-1 (also called the vapor-liquid separator), and the condensate collection tank, TK-C-100. This IAR evaluates the 242-A facility tank systems up to, but not including, the last valve or flanged connection inside the facility perimeter. The initial integrity assessment performed on the facility evaluated certain subsystems not directly in contact with dangerous waste, such as the steam condensate and used raw water subsystems, to provide technical information. These subsystems were not evaluated in this IAR. The last major upgrade to the facility was project B-534. The facility modifications, as a result of project B-534, were evaluated in the 1993 facility interim integrity assessment. Since that time, the following upgrades have occurred in the facility: installation of a process condensate recycle system, and installation of a package steam boiler to provide steam for the facility. The package boiler is not within the scope of the facility TSD

PROTECTING GROUNDWATER & THE COLUMBIA RIVER AT THE HANFORD SITE

Energy Technology Data Exchange (ETDEWEB)

GERBER, M.S.

2006-06-29

Along the remote shores of the Columbia River in southeast Washington state, a race is on. Fluor Hanford, a prime cleanup contractor to the U.S. Department of Energy (DOE) at the Hanford Site, is managing a massive, multi-faceted project to remove contaminants from the groundwater before they can reach the Columbia. Despite the daunting nature and size of the problem--about 80 square miles of aquifer under the site contains long-lived radionuclides and hazardous chemicals--significant progress is being made. Many groups are watching, speaking out, and helping. A large. passionate, diverse, and geographically dispersed community is united in its desire to protect the Columbia River--the eighth largest in the world--and have a voice in Hanford's future. Fluor Hanford and the DOE, along with the US. Environmental Protection Agency (EPA) and the Washington Department of Ecology (Ecology) interact with all the stakeholders to make the best decisions. Together, they have made some remarkable strides in the battle against groundwater contamination under the site.

Fluorescently labeled dengue viruses as probes to identify antigen-specific memory B cells by multiparametric flow cytometry.

Science.gov (United States)

Woda, Marcia; Mathew, Anuja

2015-01-01

Low frequencies of memory B cells in the peripheral blood make it challenging to measure the functional and phenotypic characteristics of this antigen experienced subset of B cells without in vitro culture. To date, reagents are lacking to measure ex vivo frequencies of dengue virus (DENV)-specific memory B cells. We wanted to explore the possibility of using fluorescently labeled DENV as probes to detect antigen-specific memory B cells in the peripheral blood of DENV immune individuals. Alexa Fluor dye-labeled DENV yielded viable virus that could be stored at -80°C for long periods of time. Using a careful gating strategy and methods to decrease non-specific binding, we were able to identify a small frequency of B cells from dengue immune individuals that bound labeled DENV. Sorted DENV(+) B cells from immune, but not naïve donors secreted antibodies that bound DENV after in vitro stimulation. Overall, Alexa Fluor dye-labeled DENVs are useful reagents to enable the detection and characterization of memory B cells in DENV immune individuals. Copyright © 2014 Elsevier B.V. All rights reserved.

Radiation Area Remedial Action FY 1996 summary report

International Nuclear Information System (INIS)

Hayward, W.M.

1996-11-01

The Radiation Area Remedial Action (RARA) project is responsible for the interim stabilization and maintenance of the majority of the inactive waste sites at the Hanford Site. These waste sites include approximately 400 individual sites and 4,000 acres. Three facilities were removed from the RARA list near the end of fiscal year (FY) 1996P: the 218-W-4B, 218-E-10, and 218-E-12B Burial Grounds. These three facilities are treatment, storage, and disposal (TSD) sites assigned to Fluor Daniel Hanford. Therefore, the RARA project will no longer perform activities on the inactive portions to maintain clear lines of responsibility (fully with Fluor Daniel Hanford). RARA activities are broken into two broad categories: interim stabilization, and surveillance and maintenance (S and M). Interim stabilization addresses major corrective actions for sites with radioactive surface contamination. A site continues to require S and M once it has received interim stabilization. Vegetation management is a significant activity under the RARA project. The goal is to control vegetation that may grow and spread radioactive contamination

Azidoperfluoroalkanes: Synthesis and Application in Copper(I)-Catalyzed Azide-Alkyne Cycloaddition

Czech Academy of Sciences Publication Activity Database

Blastik, Zsófia E.; Voltrová, Svatava; Matoušek, V.; Jurásek, Bronislav; Manley, David W.; Klepetářová, Blanka; Beier, Petr

2017-01-01

Roč. 56, č. 1 (2017), s. 346-349 ISSN 1433-7851 EU Projects: European Commission(XE) 607787 - FLUOR21 Institutional support: RVO:61388963 Keywords : azides * click reactions * fluorine * perfluoroalkanes * triazoles Subject RIV: CC - Organic Chemistry OBOR OECD: Organic chemistry Impact factor: 11.994, year: 2016 http://onlinelibrary.wiley.com/doi/10.1002/anie.201609715/full

Canberra Alpha Sentry Installation Functional Design Criteria (FDC)

International Nuclear Information System (INIS)

WHITE, W.F.

1999-01-01

This document provides the functional design criteria for the installation of the Canberra Alpha Sentry System at selected locations within the Plutonium Finishing Plant (PFP). The equipment being installed is identified by part number in Section 3 and the locations are given in Section 5. The design, procurement and installation are assigned to Fluor Federal Services

Water Pollution

International Nuclear Information System (INIS)

Goni, J.

1984-01-01

This work is about the water pollution. The air and the water interaction cycles is the main idea of the geochemical pollution conception. In the water surface as well as in the deep aquifers we can found cough metals or minerals from the athmosferic air. The activities of mercury fluor and nitrates are important to the pollution study

Biotransferencia de fluor a distintos tejidos de pejerreyes (Odontesthes bonariensis)

OpenAIRE

Volpedo, Alejandra; Puntoriero, María Laura; Fernandez Cirelli, Alicia

2016-01-01

The presence of fluorine (F), toxic trace element, has relevance in the trophic chain because it can biotrasfer to different levels. It can come from water as food, being chronic ingestion harmful to human beings. Fluorine was found in different water bodies of southwest of Buenos Aires. Chasicó Lake has the highest fluorine concentration. This water body is the most important for commercial and recreational fishing silverside (Odontesthes bonariensis) of the area. The aim of this paper is to...

Anticaries potential of commercial dentifrices as determined by fluoridation and remineralization efficiency.

Science.gov (United States)

Casals, Elias; Boukpessi, Tchilalo; McQueen, Christina M; Eversole, Sandy L; Faller, Robert V

2007-11-01

The aim of this in vitro study was to investigate fluoride uptake in human enamel after use of commercially available toothpastes containing different fluoride compounds, or combinations of fluoride actives formulated into a single product, as a means of determining the efficiency of each formula for delivering caries preventing fluoride to demineralized (caries active) enamel. Four test dentifrices and two controls were assessed and placed in groups as follows: Group 1: Lacer (Spain); Group 2: Positive control-USP Reference Standard 1100 ppm F; Group 3: Fluocaril Bi-Fluoré 250 (France); Group 4: Colgate Fluor Active (Denmark); Group 5: Elmex (France); and Group 6: A placebo (formulated the same as the USP Reference Standard toothpaste with the exception that it contained < 1 ppm F). Cores 3 mm in diameter were removed from erupted human enamel specimens (extracted by local oral surgeons for orthodontic reasons) and stored in 1% Thymol solution prior to use. They were ground and polished to remove the natural fluoride rich enamel layer, then exposed to a demineralization solution, and assessed for surface microhardness to enable randomization for use in the study. Each group of five specimens underwent a daily pH cycling procedure that involved exposure to pooled human saliva (refreshed three times daily). The groups were then exposed to dentifrice slurries four times daily for one minute per exposure and to a demineralization solution for three hours. The cycling procedure was repeated for five days. Specimens were again analyzed for surface microhardness and fluoride uptake upon completion of five days of treatment. Average surface hardness: Groups 2 and 3 showed a statistically significant greater (p<0.05) change indicating greater remineralization compared to all other groups. The average change was 23.45 for Group 2 and 22.65 for Group 3. All other groups had changes ranging from 4.25-8.62. No other statistically significant differences were observed between

Hydroxyapatite, fluor-hydroxyapatite and fluorapatite produced via the sol-gel method. Optimisation, characterisation and rheology.

Science.gov (United States)

Tredwin, Christopher J; Young, Anne M; Georgiou, George; Shin, Song-Hee; Kim, Hae-Won; Knowles, Jonathan C

2013-02-01

Currently, most titanium implant coatings are made using hydroxyapatite and a plasma spraying technique. There are however limitations associated with plasma spraying processes including poor adherence, high porosity and cost. An alternative method utilising the sol-gel technique offers many potential advantages but is currently lacking research data for this application. It was the objective of this study to characterise and optimise the production of Hydroxyapatite (HA), fluorhydroxyapatite (FHA) and fluorapatite (FA) using a sol-gel technique and assess the rheological properties of these materials. HA, FHA and FA were synthesised by a sol-gel method. Calcium nitrate and triethylphosphite were used as precursors under an ethanol-water based solution. Different amounts of ammonium fluoride (NH4F) were incorporated for the preparation of the sol-gel derived FHA and FA. Optimisation of the chemistry and subsequent characterisation of the sol-gel derived materials was carried out using X-ray Diffraction (XRD) and Differential Thermal Analysis (DTA). Rheology of the sol-gels was investigated using a viscometer and contact angle measurement. A protocol was established that allowed synthesis of HA, FHA and FA that were at least 99% phase pure. The more fluoride incorporated into the apatite structure; the lower the crystallisation temperature, the smaller the unit cell size (changes in the a-axis), the higher the viscosity and contact angle of the sol-gel derived apatite. A technique has been developed for the production of HA, FHA and FA by the sol-gel technique. Increasing fluoride substitution in the apatite structure alters the potential coating properties. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

Preparation of plutonium hexafluoride. Recovery of plutonium from waste dross (1962); Preparation de l'hexafluorure de plutonium. Recuperation du plutonium des scories d'elaboration (1962)

Energy Technology Data Exchange (ETDEWEB)

Gendre, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1962-07-01

The object of this work is to study the influence of various physical factors on the rate of fluorination of solid plutonium tetrafluoride by fluorine. In a horizontal oven with a circulation for pure fluorine at atmospheric pressure and 520 deg. C, at a fluorine rate of 9 litres/hour, it is possible to transform 3 g of tetrafluoride to hexafluoride with about 100 per cent transformation and a recovery yield of over 90 per cent, in 4 to 5 hours. The fluorination rate is a function of the temperature, of the fluorine flow-rate, of the crucible surface, of the depth of the tetrafluoride layer and of the reaction time. It does not depend on the diffusion of the fluorine into the solid but is determined by the reaction at the gas-solid interface and obeys the kinetic law (1 - T{sub T}){sup 1/3} = kt + 1. The existence of intermediate fluorides, in particular Pu{sub 4} F{sub 17}, is confirmed by a break in the Arrhenius plot at about 370 deg. C, by differences in the fluorination rates inside the tetrafluoride layer, and by reversible colour changes. The transformation to hexafluoride occurs with a purification with respect of the foreign elements present in the initial plutonium. Recovery of plutonium from waste dross: The study is based on the transformation of occluded plutonium particles to gaseous hexafluoride which is then decomposed thermally to the tetrafluoride which can be reintroduced directly in the production circuit. Under the conditions considered this process is not applicable industrially. After milling, it is possible to separate the dross into enriched (75 per cent Pu in 2.6 per cent by weight of dross) and depleted portions. By prolonged fluorination (16 hours) of the various fractions it is possible to recover about 80 per cent of the plutonium. A treatment plant using fluidization, as described at the end of this study, should make it possible to substantially improve the yield. (author) [French] L'objet de l'etude est l'influence des differents

X-ray streak and framing camera techniques

International Nuclear Information System (INIS)

Coleman, L.W.; Attwood, D.T.

1975-01-01

This paper reviews recent developments and applications of ultrafast diagnostic techniques for x-ray measurements. These techniques, based on applications of image converter devices, are already capable of significantly important resolution capabilities. Techniques capable of time resolution in the sub-nanosecond regime are being considered. Mechanical cameras are excluded from considerations as are devices using phosphors or fluors as x-ray converters

Results of dilution studies with waste from tank 241-AN-104

International Nuclear Information System (INIS)

HERTING, D.L.

1999-01-01

This report documents the completion of the B and W Hanford Company functional and Safety Review Board reviews and the Fluor Daniel Hanford review for the Plutonium Finishing Plant (PFP) Final Safety Analysis Report (FSAR), HNF-SD-CP-SAR-021, Revision 1. The reviews for the FSAR were conducted during the period from December 9, 1998 to January 14, 1999

Radiation damage studies on polystyrene-based scintillators

International Nuclear Information System (INIS)

Britvich, G.I.; Peresypkin, A.I.; Rykalin, V.I.

1991-01-01

The radiation resistance of polystyrene-based scintillators containing various scintillation dopes is reported. All samples were irradiated to 137 Cs gamma rays in air at room temperature. The examination of radiation resistance of about thirty fluorescence compounds has been made. The most radiation-hard fluores are X25, X31, 3HF and M3HF. 1 fig.; 6 tabs

Nanoscale control of Ag nanostructures for plasmonic fluorescence enhancement of near-infrared dyes

KAUST Repository

Xie, Fang

2013-05-23

Potential utilization of proteins for early detection and diagnosis of various diseases has drawn considerable interest in the development of protein-based detection techniques. Metal induced fluorescence enhancement offers the possibility of increasing the sensitivity of protein detection in clinical applications. We report the use of tunable plasmonic silver nanostructures for the fluorescence enhancement of a near-infrared (NIR) dye (Alexa Fluor 790). Extensive fluorescence enhancement of ∼2 orders of magnitude is obtained by the nanoscale control of the Ag nanostructure dimensions and interparticle distance. These Ag nanostructures also enhanced fluorescence from a dye with very high quantum yield (7.8 fold for Alexa Fluor 488, quantum efficiency (Qy) = 0.92). A combination of greatly enhanced excitation and an increased radiative decay rate, leading to an associated enhancement of the quantum efficiency leads to the large enhancement. These results show the potential of Ag nanostructures as metal induced fluorescence enhancement (MIFE) substrates for dyes in the NIR "biological window" as well as the visible region. Ag nanostructured arrays fabricated by colloidal lithography thus show great potential for NIR dye-based biosensing applications. [Figure not available: see fulltext.] © 2013 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

A fusion-spliced near-field optical fiber probe using photonic crystal fiber for nanoscale thermometry based on fluorescence-lifetime measurement of quantum dots.

Science.gov (United States)

Fujii, Takuro; Taguchi, Yoshihiro; Saiki, Toshiharu; Nagasaka, Yuji

2011-01-01

We have developed a novel nanoscale temperature-measurement method using fluorescence in the near-field called fluorescence near-field optics thermal nanoscopy (Fluor-NOTN). Fluor-NOTN enables the temperature distributions of nanoscale materials to be measured in vivo/in situ. The proposed method measures temperature by detecting the temperature dependent fluorescence lifetimes of Cd/Se quantum dots (QDs). For a high-sensitivity temperature measurement, the auto-fluorescence generated from a fiber probe should be reduced. In order to decrease the noise, we have fabricated a novel near-field optical-fiber probe by fusion-splicing a photonic crystal fiber (PCF) and a conventional single-mode fiber (SMF). The validity of the novel fiber probe was assessed experimentally by evaluating the auto-fluorescence spectra of the PCF. Due to the decrease of auto-fluorescence, a six- to ten-fold increase of S/N in the near-field fluorescence lifetime detection was achieved with the newly fabricated fusion-spliced near-field optical fiber probe. Additionally, the near-field fluorescence lifetime of the quantum dots was successfully measured by the fabricated fusion-spliced near-field optical fiber probe at room temperature, and was estimated to be 10.0 ns.

Activatable Optical Imaging with a Silica-Rhodamine Based Near Infrared (SiR700) Fluorophore: A comparison with cyanine based dyes

Science.gov (United States)

McCann, Thomas E.; Kosaka, Nobuyuki; Koide, Yuichiro; Mitsunaga, Makoto; Choyke, Peter L.; Nagano, Tetsuo; Urano, Yasuteru; Kobayashi, Hisataka

2011-01-01

Optical imaging is emerging as an important tool to visualize tumors. However, there are many potential choices among the available fluorophores. Optical imaging probes that emit in the visible range can image superficial tumors with high quantum yields, however, if deeper imaging is needed then near infrared (NIR) fluorophores are necessary. Most commercially available NIR fluorophores are cyanine based and are prone to non-specific binding and relatively limited photostability. Silica-containing rhodamine (SiR) fluorophores represent a new class of NIR fluorophores, which permit photoactivation via H-dimer formation as well as demonstrate improved photostability. This permits higher tumor-to-background ratios (TBRs) to be achieved over longer periods of time. Here, we compared an avidin conjugated with SiR700 (Av-SiR700) to similar compounds based on cyanine dyes (Av-Cy5.5 and Av-Alexa Fluor 680) in a mouse tumor model of ovarian cancer metastasis. We found that the Av-SiR700 probe demonstrated superior quenching enabling activation after binding-internalization to the target cell. As a result, Av-SiR700 had higher TBRs compared to Av-Cy5.5, and better biostability compared to Av-Alexa Fluor 680. PMID:22034863

Scintillators for fiber optics: system sensitivity and bandwidth as a function of fiber length

International Nuclear Information System (INIS)

Lutz, S.S.; Franks, L.A.; Fluornoy, J.M.; Lyons, P.B.

1981-01-01

Scintillators have been employed for several years as ionizing radiation-to-light converters in plasma diagnostic experiments that utilize fiber optics. Until recently, nanosecond and subnanosecond scintillators were available only in the near ultraviolet. However, the bandwidth and transmission properties of fiber optics both strongly favor operation at longer wavelengths. More recently, nanosecond and subnanosecond scintillators with emission peaks around 480 nm have been reported. A time-resolved plasma-imaging experiment using one of these scintillators and 100 channels of graded-index fiber, each 500 m long, has been successfully tested on a nuclear event at the Nevada Test Site. During the past year we have developed several new scintillator systems with emission wavelengths more compatible with fiber optics and with response times in the nanosecond and subnanosecond time region. One scintillator, based on Kodak dye 14567 (DCM), has an emission maximum at 650 nm and a response time (FWHM) of 1.2 ns. Experimental data on system sensitivity and bandwidth versus fiber length are presented for three fluor-fiber systems. Data on fluor formulation, response time, and linearity-of-response are given, and a model for scintillator nonlinearity, based on solvent, radiation-induced, transient absorption, is presented

Recycle Waste Collection Tank (RWCT) simulant testing in the PVTD feed preparation system

International Nuclear Information System (INIS)

Abrigo, G.P.; Daume, J.T.; Halstead, S.D.; Myers, R.L.; Beckette, M.R.; Freeman, C.J.; Hatchell, B.K.

1996-03-01

(This is part of the radwaste vitrification program at Hanford.) RWCT was to routinely receive final canister decontamination sand blast frit and rinse water, Decontamination Waste Treatment Tank bottoms, and melter off-gas Submerged Bed Scrubber filter cake. In order to address the design needs of the RWCT system to meet performance levels, the PNL Vitrification Technology (PVTD) program used the Feed Preparation Test System (FPTS) to evaluate its equipment and performance for a simulant of RWCT slurry. (FPTS is an adaptation of the Defense Waste Processing Facility feed preparation system and represents the initially proposed Hanford Waste Vitrification Plant feed preparation system designed by Fluor-Daniel, Inc.) The following were determined: mixing performance, pump priming, pump performance, simulant flow characterization, evaporator and condenser performance, and ammonia dispersion. The RWCT test had two runs, one with and one without tank baffles

Optimization of the wavelength shifter ratio in a polystyrene based plastic scintillator through energy spectrum analysis

Energy Technology Data Exchange (ETDEWEB)

Kim, Ye Won; Kim, Myung Soo; Yoo, Hyun Jun; Lee, Dae Hee; Cho, Gyu Seong [Dept. of Nuclear and Quantum Engineering, KAIST, Daejeon (Korea, Republic of); Moon, Myung Kook [Neutron Instrumentation Division, Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2017-02-15

The scintillation efficiency of the polystyrene based plastic scintillator depends on the ratio of the wavelength shifters, organic fluors (PPO and POPOP). Thus, 24 samples of the plastic scintillator were fabricated in order to find out the optimum ratio of the wavelength shifters in the plastic scintillator. The fabricated plastic scintillators were trimmed through a cutting and polishing process. They were used in gamma energy spectrum measurement with the {sup 137}Cs emitting monoenergy photon with 662 keV for the comparison of the scintillation efficiency. As a result, it was found out that the scintillator sample with 1.00 g of PPO (2,5-Diphenyloxazole) and 0.50 g of POPOP (1,4-Bis(5-phnyl-2oxidazolyl)benzene) dissolved in 100 g of styrene solution has the optimum ratio in terms of the light yield of the polystyrene based plastic scintillator.

Human Resources Staffing Plan for the Tank Farm Contractor

International Nuclear Information System (INIS)

BOSLEY, J.W.

2000-01-01

The Human Resources Staffing Plan quantified the equivalent staffing needs required for the Tank Farm Contractor (TFC) and its subcontractors to execute the readiness to proceed baseline between FY 2000-2008. The TFC staffing needs were assessed along with the staffings needs of Fluor Hanford and the privatization contractor. The plan then addressed the staffing needs and recruitment strategies required to execute the baseline

Dementia with impaired glucose metabolism in late onset metachromatic leukodystrophy

DEFF Research Database (Denmark)

Johannsen, P.; Ehlers, L.; Hansen, Hans Jacob

2001-01-01

and attention deficits with a slow psychomotor speed. MR brain imaging displayed confluent hyperintensities of periventricular and subcortical white matter. Low levels of arylsulfatase A confirmed the diagnosis. Impaired cortical glucose metabolism especially of the medial temporal and frontal cortices...... was observed using positron emission tomography and fluor-18-labeled fluorodesoxyglucose. The neuropsychological deficits are related to the location of deficits in glucose metabolism....

Synthesis and nucleophilic aromatic substitution of 3-fluoro-5-nitro-1-(pentafluorosulfanyl)benzene

Czech Academy of Sciences Publication Activity Database

Ajenjo, Javier; Greenhall, M.; Zarantonello, C.; Beier, Petr

2016-01-01

Roč. 12, Feb 3 (2016), s. 192-197 ISSN 1860-5397 EU Projects: European Commission(XE) 607787 - FLUOR21 Institutional support: RVO:61388963 Keywords : direct fluorination * fluorine * nucleophilic aromatic substitution * pentafluorosulfanyl group * vicarious nucleophilic substitution Subject RIV: CC - Organic Chemistry Impact factor: 2.337, year: 2016 http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-12-21

Role of Integrin Alpha 5 in ErbB2-Mediated Breast Cancer

Science.gov (United States)

2009-09-01

AD__ ( Leave blank) _______________ Award Number: W81XWH-08-1...3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 using Guava Technologies EasyCyte Plus, and data analyzed with Guava ...dilution, washed, and incubated with secondary antibody (AlexaFluor mouse 488, Invitrogen) at a 1:200 dilution. Cells were read on a Guava Technologies

Positron emission tomography. Basic principles

International Nuclear Information System (INIS)

Rodriguez, Jose Luis; Massardo, Teresa; Gonzalez, Patricio

2001-01-01

The basic principles of positron emission tomography (PET) technique are reviewed. lt allows to obtain functional images from gamma rays produced by annihilation of a positron, a positive beta particle. This paper analyzes positron emitters production in a cyclotron, its general mechanisms, and the various detection systems. The most important clinical applications are also mentioned, related to oncological uses of fluor-l8-deoxyglucose

High effective atomic number polymer scintillators for gamma ray spectroscopy

Science.gov (United States)

Cherepy, Nerine Jane; Sanner, Robert Dean; Payne, Stephen Anthony; Rupert, Benjamin Lee; Sturm, Benjamin Walter

2014-04-15

A scintillator material according to one embodiment includes a bismuth-loaded aromatic polymer having an energy resolution at 662 keV of less than about 10%. A scintillator material according to another embodiment includes a bismuth-loaded aromatic polymer having a fluor incorporated therewith and an energy resolution at 662 keV of less than about 10%. Additional systems and methods are also presented.

Human endothelial progenitor cells internalize high-density lipoprotein.

Directory of Open Access Journals (Sweden)

Kaemisa Srisen

Full Text Available Endothelial progenitor cells (EPCs originate either directly from hematopoietic stem cells or from a subpopulation of monocytes. Controversial views about intracellular lipid traffic prompted us to analyze the uptake of human high density lipoprotein (HDL, and HDL-cholesterol in human monocytic EPCs. Fluorescence and electron microscopy were used to investigate distribution and intracellular trafficking of HDL and its associated cholesterol using fluorescent surrogates (bodipy-cholesterol and bodipy-cholesteryl oleate, cytochemical labels and fluorochromes including horseradish peroxidase and Alexa Fluor® 568. Uptake and intracellular transport of HDL were demonstrated after internalization periods from 0.5 to 4 hours. In case of HDL-Alexa Fluor® 568, bodipy-cholesterol and bodipy-cholesteryl oleate, a photooxidation method was carried out. HDL-specific reaction products were present in invaginations of the plasma membrane at each time of treatment within endocytic vesicles, in multivesicular bodies and at longer periods of uptake, also in lysosomes. Some HDL-positive endosomes were arranged in form of "strings of pearl"- like structures. HDL-positive multivesicular bodies exhibited intensive staining of limiting and vesicular membranes. Multivesicular bodies of HDL-Alexa Fluor® 568-treated EPCs showed multilamellar intra-vacuolar membranes. At all periods of treatment, labeled endocytic vesicles and organelles were apparent close to the cell surface and in perinuclear areas around the Golgi apparatus. No HDL-related particles could be demonstrated close to its cisterns. Electron tomographic reconstructions showed an accumulation of HDL-containing endosomes close to the trans-Golgi-network. HDL-derived bodipy-cholesterol was localized in endosomal vesicles, multivesicular bodies, lysosomes and in many of the stacked Golgi cisternae and the trans-Golgi-network Internalized HDL-derived bodipy-cholesteryl oleate was channeled into the lysosomal

A quantum dot-immunofluorescent labeling method to investigate the interactions between a crinivirus and its whitefly vector

Directory of Open Access Journals (Sweden)

James C. K. Ng

2013-04-01

Full Text Available Successful vector-mediated plant virus transmission entails an intricate but poorly understood interplay of interactions among virus, vector, and plant. The complexity of interactions requires continually improving/evaluating tools and methods for investigating the determinants that are central to mediating virus transmission. A recent study using an organic fluorophore (Alexa Fluor-based immunofluorescent localization assay demonstrated that specific retention of Lettuce infectious yellows virus (LIYV virions in the anterior foregut or cibarium of its whitefly vector is required for virus transmission. Continuous exposure of organic fluorophore to high excitation light intensity can result in diminished or loss of signals, potentially confounding the identification of important interactions associated with virus transmission. This limitation can be circumvented by incorporation of photostable fluorescent nanocrystals, such as quantum dots (QDs, into the assay. We have developed and evaluated a QD-immunofluorescent labeling method for the in vitro and in situ localization of LIYV virions based on the recognition specificity of streptavidin-conjugated QD605 (S-QD605 for biotin-conjugated anti-LIYV IgG (B-αIgG. IgG biotinylation was verified in a blot overlay assay by probing SDS-PAGE separated B-αIgG with S-QD605. Immunoblot analyses of LIYV using B-αIgG and S-QD605 resulted in a virus detection limit comparable to that of DAS-ELISA. In membrane feeding experiments, QD signals were observed in the anterior foregut or cibarium of virion-fed whitefly vectors but absent in those of virion-fed whitefly non-vectors. Specific virion retention in whitefly vectors corresponded with successful virus transmission. A fluorescence photobleaching assay of viruliferous whiteflies fed B-αIgG and S-QD605 vs. those fed anti-LIYV IgG and Alexa Fluor 488-conjugated IgG revealed that QD signal was stable and deteriorated ∼7 to 8 fold slower than that of Alexa

FINAL FRONTIER AT HANFORD TACKLING THE CENTRAL PLATEAU

International Nuclear Information System (INIS)

GERBER MS

2008-01-01

The large land area in the center of the vast Department of Energy (DOE) Hanford Site in southeast Washington State is known as 'the plateau'--aptly named because its surface elevations are 250-300 feet above the groundwater table. By contrast, areas on the 585-square mile Site that border the Columbia River sit just 30-80 feet above the water table. The Central Plateau, which covers an ellipse of approximately 70 square miles, contains Hanford's radiochemical reprocessing areas--the 200 East and 200 West Areas--and includes the most highly radioactive waste and contaminated facilities on the Site. Five 'canyons' where chemical processes were used to separate out plutonium (Pu), 884 identified soil waste sites (including approximately 50 miles of solid waste burial trenches), more than 900 structures, and all of Hanford's liquid waste storage tanks reside in the Central Plateau. (Notes: Canyons is a nickname given by Hanford workers to the chemical reprocessing facilities. The 177, underground waste tanks at Hanford comprise a separate work scope and are not under Fluor's management). Fluor Hanford, a DOE prime cleanup contractor at the Site for the past 12 years, has moved aggressively to investigate Central Plateau waste sites in the last few years, digging more than 500 boreholes, test pits, direct soil 'pushes' or drive points; logging geophysical data sets; and performing electrical-resistivity scans (a non-intrusive technique that maps patterns of sub-surface soil conductivity). The goal is to identify areas of contamination areas in soil and solid waste sites, so that cost-effective and appropriate decisions on remediation can be made. In 2007, Fluor developed a new work plan for DOE that added 238 soil waste-site characterization activities in the Central Plateau during fiscal years (FYs) 2007-2010. This number represents a 50 percent increase over similar work previously done in central Hanford. Work Plans are among the required steps in the Comprehensive

Air and smear sample calculational tool for Fluor Hanford Radiological control

International Nuclear Information System (INIS)

BAUMANN, B.L.

2003-01-01

A spreadsheet calculation tool was developed to automate the calculations performed for determining the concentration of airborne radioactivity and smear counting as outlined in HNF--13536, Section 5.2.7, ''Analyzing Air and Smear Samples''. This document reports on the design and testing of the calculation tool. Radiological Control Technicians (RCTs) will save time and reduce hand written and calculation errors by using an electronic form for documenting and calculating work place air samples. Current expectations are RCTs will perform an air sample and collect the filter or perform a smear for surface contamination. RCTs will then survey the filter for gross alpha and beta/gamma radioactivity and with the gross counts utilize either hand calculation method or a calculator to determine activity on the filter. The electronic form will allow the RCT with a few key strokes to document the individual's name, payroll, gross counts, instrument identifiers; produce an error free record. This productivity gain is realized by the enhanced ability to perform mathematical calculations electronically (reducing errors) and at the same time, documenting the air sample

Fluor determination by alkaline hydrolysis of the uranium and thorium fluorides

International Nuclear Information System (INIS)

Barrachina Gomez, L.; Gasco Sanchez, L.

1961-01-01

The alkaline hydrolysis of the uranium and thorium fluorides is studded and a new method for the determination of the fluoride, on the basis of a indirect volumetric titration with standard soda, is proposed. The compounds that may influence the hydrolysis of the uranium fluoride and that may be occasionally found in it as impurities are also studied. the method can be applied to the uranium fluoride except when there is a great quantity of F 2 UO 2 or UO 3 present in the sample. (Author) 20 refs

Characterization of an anthraquinone fluor from the bioluminescent, pelagic polychaete Tomopteris

Science.gov (United States)

Francis, Warren R; Powers, Meghan L; Haddock, Steven H D

2014-01-01

Tomopteris is a cosmopolitan genus of polychaetes. Many species produce yellow luminescence in the parapodia when stimulated. Yellow bioluminescence is rare in the ocean, and the components of this luminescent reaction have not been identified. Only a brief description, half a century ago, noted fluorescence in the parapodia with a remarkably similar spectrum to the bioluminescence, which suggested that it may be the luciferin or terminal light-emitter. Here, we report the isolation of the fluorescent yellow–orange pigment found in the luminous exudate and in the body of the animals. Liquid chromatography-mass spectrometry revealed the mass to be 270 m/z with a molecular formula of C15H10O5, which ultimately was shown to be aloe-emodin, an anthraquinone previously found in plants. We speculate that aloe-emodin could be a factor for resonant-energy transfer or the oxyluciferin for Tomopteris bioluminescence. PMID:24760626

Re-injection accelerates groundwater clean up at Fernald, Fluor Fernald, Inc

International Nuclear Information System (INIS)

Dave Brettschneider; William Hertel; Ken Broberg

2000-01-01

A successful one year long, field scale demonstration of the use of groundwater re-infection at Fernald was recently completed bringing DOE one step closer to achieving an accelerated site remediation (DOE 2000). The demonstration marks the end of a several year effort to evaluate whether: re-injection could be conducted efficiently at Fernald, and if the approved aquifer remedy at Fernald would benefit by incorporating re-infection. Evaluation of re-injection technology involved not only technical considerations, but also participation and cooperation of regulators and stakeholders. The demonstration was considered to be unique in that it was integrated into the design of the current approved aquifer remedy and utilized the existing remediation infrastructure. Information collected during the demonstration indicated that re-injection wells could be operated efficiently at Fernald and that the current approved groundwater remedy should be modified to include the use of re-injection

Applicable safety-related design and operations considerations from the oil and chemical industries

International Nuclear Information System (INIS)

Mulvihill, R.J.; Deshotels, R.L.; Master, C.A.

1987-01-01

Fluor Daniel has conducted several hazards and risk analyses on petroleum and chemical facilities. These analyses included qualitative hazards and operability (HAZOP) studies, preliminary hazards analyses, and qualitative fault-tree analysis as well as quantitative event-tree/fault-tree risk analysis. Several design-related problem areas were uncovered as a result of these analyses as well as deficiencies in operations and maintenance. Design deficiency areas include potential common-mode failures associated with redundant functions sharing a common distributed digital control (DDC) logic circuit board and failures in pressure relief systems. Many of the design weaknesses and potential operator errors discussed have a direct counterpart in nuclear fuel processing plants and nuclear power reactors. Counterparts that are discussed are common cause/common mode failures in control systems and failures in pressure relief systems. Overpressurization of piping and vessels resulting in rupture is discussed. Mitigating design features and operations procedures that have been implemented in the chemical process industry are described and their applicability to the nuclear industry is discussed

Integrative Lifecourse and Genetic Analysis of Military Working Dogs

Science.gov (United States)

2013-10-01

FITC) and Alexa Fluor 647 (BD Biosciences), respectively. Secondary antibodies of either phycoerythrin (PE; 5 μL) or fluorescein isothiocyanate (FITC; 1...zone B cells [2]. Cytokines/cytokine receptors, Ig recognition , and antigen presented by APCs, dendritic cells, and/or macrophages can initiate...MetaMap is targeted at finding medical terms from a biomedical text, it leverages a combination of part-of- speech tagging, shallow parsing, and longest

First Cases of Spotted Fever Group Rickettsiosis in Thailand

Science.gov (United States)

1994-01-01

discernible fluorescing organisms. MATERIALS AND METHODS Fluore-cein-conjugated rabbit anti-human iam- All three patients were seen at Chiang Mai munoglobulin...IgG) (heavy and light chain spe- University Hospital. Chiang Mai (population cific: Cappel Laboratories, Cochranville. PA) 1.300,000) is one of the 76...ulty of Medicine at Chiang Mai University. established procedures.." Horseradish peroxi- Chiang Mai University Hospital. a 1.000-bed dase-labeled mouse

Transplantation and Perfusion of Microvascular Fragments in a Rodent Model of Volumetric Muscle Loss Injury

Science.gov (United States)

2014-07-01

and eosin (H&E) or Wheat Germ Agglutinin (WGA), Alexa Fluor® 488 conjugate (1:50 dilution, Invitrogen, Carlsbad, CA, USA) to stain for cellular...1:500), Invitrogen). Tissue containing MVFs isolated from GFP transgenic animals were sectioned as described above, fixed with 4... transgenic animals were transplanted into VML defects to determine if the vascularity we observed was a result of the transplanted vessels or was due to

Minutes of the Explosives Safety Seminar (25th) Held in Anaheim, California on 18-20 August 1992. Volume 3

Science.gov (United States)

1992-08-20

Secretary of Defense for Environment KEYNOTE ADDRESS ...................................................... 7 Mr. Colin McMillan, Assistant Secretary...11-547 McGuinness, Jack 111-161 Soleau, Edward W. 11-123 McMahon, Gordon W. 11-277 Song, So-Young 1-429, 11-85 McMillan, Colin 1-7 Spivey, Kathy H. 11...DRAKE JAMES APPLIED RESEARCH ASSOC. INC. MR. DRAKE RICHARD FLUOR DANIEL MR. DRURY CHUCK SHAMROCK SERVICES MR. DUA BALBIR DAY & ZIMMERMANN, INC. MR

Study of the dry processing of uranium ores; Etude des traitements de minerais d'uranium par voie seche

Energy Technology Data Exchange (ETDEWEB)

Guillet, H

1959-02-01

A description is given of direct fluorination of pre-concentrated uranium ores in order to obtain the hexafluoride. After normal sulfuric acid treatment of the ore to eliminate silica, the uranium is precipitated by a load of lime to obtain: either impure calcium uranate of medium grade, or containing around 10% of uranium. This concentrate is dried in an inert atmosphere and then treated with a current of elementary fluorine. The uranium hexafluoride formed is condensed at the outlet of the reaction vessel and may be used either for reduction to tetrafluoride and the subsequent manufacture of uranium metal or as the initial product in a diffusion plant. (author) [French] Il s'agit d'une description de fluoration directe de preconcentres de minerais d'uranium en vue d'obtention d'hexafluorure. Apres attaque sulfurique normale du minerai, afin d' eliminer la silice, l' uranium est precipite par un toit de chaux pour obtenir: ou uranate de chaux impur de titre moyen, ou uranium de la dizaine du pourcentage. Ce concentre seche en atmosphere inerte est soumis a un courant de fluor elementaire. L'hexafluorure d'uranium forme est condense a la sortie du reacteur et peut etre utilise soit apres reduction en tetrafluorure par l'elaboration d'uranium metal, soit comme produit de base dans le cadre d'une usine de diffusion. (auteur)

Waste Treatment Plant Liquid Effluent Treatability Evaluation

International Nuclear Information System (INIS)

LUECK, K.J.

2001-01-01

Bechtel National, Inc. (BNI) provided a forecast of the radioactive, dangerous liquid effluents expected to be generated by the Waste Treatment Plant (WTP). The forecast represents the liquid effluents generated from the processing of 25 distinct batches of tank waste through the WTP. The WTP liquid effluents will be stored, treated, and disposed of in the Liquid Effluent Retention Facility (LERF) and the Effluent Treatment Facility (ETF). Fluor Hanford, Inc. (FH) evaluated the treatability of the WTP liquid effluents in the LERFIETF. The evaluation was conducted by comparing the forecast to the LERFIETF treatability envelope, which provides information on the items that determine if a liquid effluent is acceptable for receipt and treatment at the LERFIETF. The WTP liquid effluent forecast is outside the current LERFlETF treatability envelope. There are several concerns that must be addressed before the WTP liquid effluents can be accepted at the LERFIETF

Beam structure and transverse emittance studies of high-energy ion beams

International Nuclear Information System (INIS)

Saadatmand, K.; Johnson, K.F.; Schneider, J.D.

1991-01-01

A visual diagnostic technique has been developed to monitor and study ion beam structure shape and size along a transport line. In this technique, a commercially available fluorescent screen is utilized in conjunction with a video camera. This visual representation of the beam structure is digitized and enhanced through use of false-color coding and displayed on a TV monitor for on-line viewing. Digitized information is stored for further off-line processing (e.g., extraction of beam profiles). An optional wire grid placed upstream of the fluor screen adds the capability of transverse emittance (or angular spread) measurement to this technique. This diagnostic allows real-time observation of the beam response to parameter changes (e.g., evolution of the beam structure, shifts in the beam intensity at various spatial locations within the beam perimeter, and shifts in the beam center and position). 3 refs., 5 figs

Transparent lithiated polymer films for thermal neutron detection

Energy Technology Data Exchange (ETDEWEB)

Mabe, Andrew N., E-mail: andrew.n.mabe@gmail.com [Department of Chemistry, University of Tennessee, Knoxville, TN 37996 (United States); Auxier, John D. [Department of Chemistry, University of Tennessee, Knoxville, TN 37996 (United States); Urffer, Matthew J. [Department of Nuclear Engineering, University of Tennessee, Knoxville, TN 37996 (United States); Penumadu, Dayakar [Department of Civil and Environmental Engineering, University of Tennessee, Knoxville, TN 37996 (United States); Schweitzer, George K. [Department of Chemistry, University of Tennessee, Knoxville, TN 37996 (United States); Miller, Laurence F. [Department of Nuclear Engineering, University of Tennessee, Knoxville, TN 37996 (United States)

2013-09-11

Novel water-soluble {sup 6}Li loaded copolymer scintillation films have been designed and fabricated to detect thermal neutrons. Styrene and maleic anhydride were copolymerized to form an alternating copolymer, then the anhydride functionality was hydrolyzed using {sup 6}Li hydroxide. The resulting poly(styrene-co-lithium maleate) was mixed with salicylic acid as a fluor and cast as a thin film from water. The maximum {sup 6}Li loading obtained that resulted in a transparent film was 4.36% by mass ({sup 6}Li to polymer). The optimum fluorescence output was obtained for 11.7% salicylic acid by mass, presumably in the form of lithium salicylate, resulting in an optimum film containing 3.85% by mass of {sup 6}Li. A facile and robust synthesis method, film fabrication protocol, photoluminescence results, and scintillation responses are reported herein. -- Highlights: • A transparent polymer scintillator containing 3.85 wt% {sup 6}Li has been synthesized. • This class of polymeric thermal neutron scintillation detector is water-soluble. • Salicylic acid, presumably in the form of lithium salicylate, is used as a fluor. • The material emits 373 photons/α ({sup 241}Am) and an average of 139 photons/β ({sup 36}Cl). • The material emits 360 photons per thermal neutron capture event.

The influence of varnish and high fluoride on erosion and abrasion in a laboratory investigation.

Science.gov (United States)

Sar Sancakli, H; Austin, R S; Al-Saqabi, F; Moazzez, R; Bartlett, D

2015-03-01

The aim of this study was to investigate the potential of concentrated fluoride varnishes to reduce enamel loss from repeated cycles of citric acid erosion and toothbrush abrasion in vitro. Polished human enamel samples were exposed to fluoride varnishes: Bifluorid10® (NaF&CaF2- 45,200 ppmF), Duraphat® (NaF 22,600 ppmF), Fluor-Protector® (difluorsilane 1000 ppmF) and a control coating of copal ether varnish (0 ppmF) group and a deionized water group. For each group of 16 samples, nine cycles of erosion and nine cycles of erosion-abrasion [1 cycle=erosion (0.3% citric acid, pH 3.2, 5 min)+artificial saliva (1 h, pH 7.0)+abrasion (120 linear strokes in artificial saliva from Oral B medium soft brushes 300 g loading]. The change in the enamel surface was evaluated using optical profilometry. Duraphat® and Bifluorid10® applications had a median (IQR) step height of 4.21 um (1.59) and 5.01 um (1.02). This was statistically significantly less than Fluor-Protector® 6.83 um (1.25), copal ether 7.22 um (1.97) and water 7.39 um (1.96) (pDental Association.

["Mixed" and "miscellaneous" vulvovaginitis: diagnostics and therapy of vaginal administration of nystatin and nifuratel].

Science.gov (United States)

Cepický, P; Malina, J; Líbalová, Z; Kuzelová, M

2005-05-01

The evaluation of combined and miscellaneous vulvovaginal infections incidence and their treatment with combined vaginal products containing nifuratel and nystatin. Prospective study. Gynecologic outpatient department LEVRET, Prague; Laboratories of Microbiology AescuLab, Prague. 70 consecutive patients were examined with complaint of vaginal fluor and/or pruritus. We established macroscopic features of fluor, pH, amine test and mounts stained with Giemsa and Gram. We qualified the cases with more diagnostic criteria (mycosis, lactobacillosis, anaerobic vaginosis, aerobic vaginitis) as combined infection, those with no diagnostic criteria as miscellaneous. We treated all patients with vaginal tablets nystatin + nifuratel (Macmiror complex). We prescribed clotrimazol cream, if pruritus was present. We evaluated withdrawals of symptoms and relapses during 3 months after treatment. Combined infection was found in 21 patients from 70 (30%). The most frequent combination was that of mycosis and aerobic vaginitis (13/70, 18.6%) or mycosis and anaerobic vaginosis (4/70, 5.7%); 11 patients fulfilled criteria of no diagnosis. We concluded them as "miscelaneous". The treatment was successful in all cases, 10 women relapsed in 3 months. Combined vaginal infection findings are present very often (30%), likewise miscellaneous ones (15%) occur. The treatment of these women in successful with vaginal tablets with nystatin + nifuratel.

Evanescent Wave Fiber Optic Biosensor for Salmonella Detection in Food

Directory of Open Access Journals (Sweden)

Arun K. Bhunia

2009-07-01

Full Text Available Salmonella enterica is a major food-borne pathogen of world-wide concern. Sensitive and rapid detection methods to assess product safety before retail distribution are highly desirable. Since Salmonella is most commonly associated with poultry products, an evanescent wave fiber-optic assay was developed to detect Salmonella in shell egg and chicken breast and data were compared with a time-resolved fluorescence (TRF assay. Anti-Salmonella polyclonal antibody was immobilized onto the surface of an optical fiber using biotin-avidin interactions to capture Salmonella. Alexa Fluor 647-conjugated antibody (MAb 2F-11 was used as the reporter. Detection occurred when an evanescent wave from a laser (635 nm excited the Alexa Fluor and the fluorescence was measured by a laser-spectrofluorometer at 710 nm. The biosensor was specific for Salmonella and the limit of detection was established to be 103 cfu/mL in pure culture and 104 cfu/mL with egg and chicken breast samples when spiked with 102 cfu/mL after 2–6 h of enrichment. The results indicate that the performance of the fiber-optic sensor is comparable to TRF, and can be completed in less than 8 h, providing an alternative to the current detection methods.

Overview on the history of organofluorine chemistry from the viewpoint of material industry

OpenAIRE

Okazoe, Takashi

2009-01-01

Fluorine (from ?le fluor?, meaning ?to flow?) is a second row element of Group 17 in the periodic table. When bound to carbon it forms the strongest bond in organic chemistry to give organofluorine compounds. The scientific field treating them, organofluorine chemistry, started before elemental fluorine itself was isolated. Applying the fruits in academia, industrial organofluorine chemistry has developed over 80 years via dramatic changes during World War II. Nowadays, it provides various ma...

SITUATION OF FLUORIDES RATE IN WATERS AND MAJOR ...

African Journals Online (AJOL)

31 déc. 2010 ... by fluoride ions in the waters of the region (Fluorosis Dental and skeletal). This study proposes, the estimated daily intake of fluoride from its water .... Le fluor est dosé par la méthode potentiométrique (NF T 90-004) grâce à une électrode spécifique aux ions fluorures. La mesure du potentiel a été effectuée ...

Heat-resistant hydrophobic-oleophobic coatings

OpenAIRE

Uyanik, Mehmet; Arpac, Ertugrul; Schmidt, Helmut K.; Akarsu, Murat; Sayilkan, Funda; Sayilkan, Hikmet

2006-01-01

Thermally and chemically durable hydrophobic oleophobic coatings, containing different ceramic particles such as SiO2, SiC, Al 2O3, which can be alternative instead of Teflon, have been developed and applied on the aluminum substrates by spin-coating method. Polyimides, which are high-thermal resistant heteroaromatic polymers, were synthesized, and fluor oligomers were added to these polymers to obtain hydrophobic-oleophobic properties. After coating, Al surface was subjected to Taber-abrasio...

Sensitivity of Breast Cancer Stem Cells to TRA-8 Anti-DR5 Monoclonal Antibody

Science.gov (United States)

2013-08-01

Janelia Farm , VA, travel award 2010 -­‐ Translational Medicine Symposium, HHMI Peer Cluster Meeting, travel award 2010 -­‐ AACR Annual Conference...lab. Science Education Alliance, Janelia Farm , VA, 2001 3. Londoño-Joshi AI, Forero-Torres A, Fineberg NS, Oliver PG, Zhou T, LoBuglio AF, Buchsbaum...rabbit mAb and cleaved caspase 3 rabbit mAb were purchased from Cell Signaling (Billerica, MA). Secondary antibodies, Alexa fluor 405 goat anti-rabbit

Minutes of the Explosives Safety Seminar (25). Volume 4. Held in Anaheim, California on 18-20 Aug 1992

Science.gov (United States)

1992-08-01

7 Mr. Colin McMillan, Assistant Secretary of Defense for Production and Logistics NAVY SA FETY...McMahon, Gordon W. 11-277 Song, So-Young 1-429, 11-85 McMillan, Colin 1-7 Spivey, Kathy H. 11-547 McQueen, D. IV-203 Starkenberg, John 1-183 McVay, L. IV...FLUOR DANIEL MR. DRURY CHUCK SHAMROCK SERVICES MR. DUA BALBIR DAY & ZIMMERMANN, INC. MR. DUCHOCK JEFF MR. DUDLEY MICHAEL DEFENSE LOGISTICS AGENCY

ASSET RECOVERY OF HAZARDOUS MATERIALS BENEFICIAL REUSE OF RADIOLOGICALLY ENCUMBERED LEAD STOCKS

International Nuclear Information System (INIS)

Lloyd, E.R.; Meehan, R.W.

2003-01-01

nd stewardship of the waste was eliminated. Methods and processes developed in cooperation with Fluor Hanford are applicable to, and have been successfully applied to, lead stocks at DOE sites such as Savannah River, Mound, Los Alamos, and Idaho

Development of an automatic smear sampler and a polymer film for surface radioactive contamination assay

International Nuclear Information System (INIS)

Seo, B.-K.; Lee, K.-W.; Woo, Z.-H.; Jeong, K.-S.; Oh, W.-Z.; Han, M.-J.

2004-01-01

Measurement of the surface contamination by an indirect method is subject to the various kinds of error according to the sampling person and needs much time and effort in the sampling and assay. In this research, an automatic smear sampler is developed. It improved efficiency for assay work of surface contamination level achieved periodically in a radiation controlled area. Using an automatic smear sampler developed, it is confirmed that radioactive contaminated materials are uniformly transferred to smear paper more than any sampling method by an operator. Also, Solid scintillation proximity membranes were prepared for measuring the amount of radioactive contamination in laboratories contaminated by the low energy beta-ray emitter, such as 3 H and 14 C. Polysulfone scintillation proximity membranes were prepared by impregnating Cerium Activated Yttrium Silicate (CAYS), an inorganic fluor, in a membrane structure. The inorganic fluor-impregnated membranes were applied to detect the radioactive surface contamination. The preparation of membranes was divided into two processes. A supporting polymer film was made of casting solutions consisting of polysulfone and solvent, their cast film being solidified by vacuum evaporation. CAYS-dispersed polymer solutions were cast over the first, solidified polymer films and coagulated either by evaporating solvent in the solution with non-solvent in a coagulation bath. The prepared membranes had two distinguished, but tightly attached, double layers : one is the supporting layer of dense polymer film and the other results revealed that the prepared membranes were efficient to monitor radioactive contamination with reliable counting ability. For enhancement of pick-up and measurement efficiency, the membrane was prepared with the condition of different membrane solidification. The scintillation produced by interaction with radiation and CAYS was measured with photomultiplier tube. The test results showed that the prepared

Mid-Infrared Fiber Lasers (Les fibres laser infrarouge moyen)

Science.gov (United States)

2010-09-01

Marcel Poulain, Université de Rennes / Le Verre Fluoré, France Fluoride Fiber Sources: Problems and Prospects Prof. Marcel Poulain from Rennes...currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 2. REPORT TYPE 3. DATES...Les fibres laser infrarouge moyen (RTO-MP-SET-171) Synthèse Les sources laser en infrarouge moyen sont nécessaires aux systèmes actifs de

Bright photoactivatable fluorophores for single-molecule imaging.

Science.gov (United States)

Grimm, Jonathan B; English, Brian P; Choi, Heejun; Muthusamy, Anand K; Mehl, Brian P; Dong, Peng; Brown, Timothy A; Lippincott-Schwartz, Jennifer; Liu, Zhe; Lionnet, Timothée; Lavis, Luke D

2016-12-01

Small-molecule fluorophores are important tools for advanced imaging experiments. We previously reported a general method to improve small, cell-permeable fluorophores which resulted in the azetidine-containing 'Janelia Fluor' (JF) dyes. Here, we refine and extend the utility of these dyes by synthesizing photoactivatable derivatives that are compatible with live-cell labeling strategies. Once activated, these derived compounds retain the superior brightness and photostability of the JF dyes, enabling improved single-particle tracking and facile localization microscopy experiments.

Safety Evaluation for Packaging (onsite) T Plant Canyon Items

International Nuclear Information System (INIS)

OBRIEN, J.H.

2000-01-01

This safety evaluation for packaging (SEP) evaluates and documents the ability to safely ship mostly unique inventories of miscellaneous T Plant canyon waste items (T-P Items) encountered during the canyon deck clean off campaign. In addition, this SEP addresses contaminated items and material that may be shipped in a strong tight package (STP). The shipments meet the criteria for onsite shipments as specified by Fluor Hanford in HNF-PRO-154, Responsibilities and Procedures for all Hazardous Material Shipments

QUEST Hanford Site Computer Users - What do they do?

Energy Technology Data Exchange (ETDEWEB)

WITHERSPOON, T.T.

2000-03-02

The Fluor Hanford Chief Information Office requested that a computer-user survey be conducted to determine the user's dependence on the computer and its importance to their ability to accomplish their work. Daily use trends and future needs of Hanford Site personal computer (PC) users was also to be defined. A primary objective was to use the data to determine how budgets should be focused toward providing those services that are truly needed by the users.

2008-IJBCS-Article Kalpy Julien Coulybaly

African Journals Online (AJOL)

hp

éclairée par 4 ampoules néon MAZDA. FLUOR M2TF 36W/LJ de 1,2 m de long, de. 32 Watt produisant une lumière type lumière du jour de 3350 lumens chacun. D'où une intensité lumineuse globale de 706,66 lux. Une seconde expérience avec une légère modification de la composition des milieux. Bold et Conways, une ...

Center for the Evaluation of Biomarkers for the Early Detection of Breast Cancer

Science.gov (United States)

2009-10-01

Table S1, including mammography (BI-RADS) score and breast density at the last mammogram before diagnosis, lymph node positivity, tumor size, number of...Bibliography 1.& Fletcher RH. Should all people over the age of 50 have regular fecal occult-blood tests? If it works, why not do it? New England Journal...blocked for 15 minutes at room temperature in fluores- cence-activated cell sorting (FACS) buffer (PBS, 0.1% bovine serum albumin (BSA), 0.02% sodium

Safety Evaluation for Packaging (onsite) T Plant Canyon Items

Energy Technology Data Exchange (ETDEWEB)

OBRIEN, J.H.

2000-07-14

This safety evaluation for packaging (SEP) evaluates and documents the ability to safely ship mostly unique inventories of miscellaneous T Plant canyon waste items (T-P Items) encountered during the canyon deck clean off campaign. In addition, this SEP addresses contaminated items and material that may be shipped in a strong tight package (STP). The shipments meet the criteria for onsite shipments as specified by Fluor Hanford in HNF-PRO-154, Responsibilities and Procedures for all Hazardous Material Shipments.

The Seven Brothers. The changing world of petrochemical multinationals

International Nuclear Information System (INIS)

Van Ammelrooij, A.

2000-01-01

Since the eighties oil companies do not build their own drilling installations and refineries, but contract out such construction activities to engineering contractors. An overview is given of the market of the so-called Seven Brother (analogue to Seven Sisters for the oil companies) and the changes that are taking place at the moment. The Seven Brothers are Asea Brown Boveri (USA), Fluor Corp (US), Kvaerner ASA (Norway), Foster Wheeler (UK), Jacobs (USA), Morrison Knudsen (USA), and Parsons (UK)

The use of selective electrodes for the control of nuclear materials

International Nuclear Information System (INIS)

Pires, M.A.F.; Abrao, A.

1984-01-01

The use of ion selective electrodes is discussed for the determination of nitrate, chloride and fluoride in several materials used in the fuel cycle. The determination of nitrate and chloride in thorium compounds, the analysis of fluoride and chloride in uranium compounds and the determination of fluoride in crude phosphoric acid are described. The control of fluoride in urine of individuals that handle materials containing fluor and its compounds is also described. (C.L.B.) [pt

Fluor-Hanford 3013 Digital Radiography Dead Zone Mitigation Project Pressure Test Report

International Nuclear Information System (INIS)

Gibbs, K.

2003-01-01

The use of digital radiographic (DR) measurement of lid deflection as an indication of pressurization of the 3013 inner can was first reported by the Savannah River Technology Center (SRTC). The conclusions of this report were that for cans with relatively large initial concavity, lid deflection could be used to meet the 3013 standard (DOE-STD-3013-2000) requirement for a nondestructive indication of a pressurization of 100 psig. During acceptance testing of the system in the Spring of 2003, it was confirmed that for some cans the DR measured lid deflection could become insensitive to the change in lid deflection when compared to actual mechanical measurements. The basic explanation of this phenomenon is that characteristics of the lid geometry such as tilt and wobble can obfuscate the bottom of the lid where the deflection is measured. The purpose of this report is to document the results of the pressure testing and the efficacy of the alternate imaging and analysis methods developed to mitigate the dead zone problem. Prior to review of the results, a review of the current method and an introduction to the newly developed methods and techniques is provided

Clinical assessment of demineralization and remineralization surrounding orthodontic brackets with FluoreCam

Directory of Open Access Journals (Sweden)

Bora Korkut

2017-04-01

Conclusions: This study demonstrated that demineralization is measurable around orthodontic brackets and the demineralization can be completely inhibited and/or reversed by the use of commercially available remineralization products.

Glycan characterization of the NIST RM monoclonal antibody using a total analytical solution: From sample preparation to data analysis.

Science.gov (United States)

Hilliard, Mark; Alley, William R; McManus, Ciara A; Yu, Ying Qing; Hallinan, Sinead; Gebler, John; Rudd, Pauline M

Glycosylation is an important attribute of biopharmaceutical products to monitor from development through production. However, glycosylation analysis has traditionally been a time-consuming process with long sample preparation protocols and manual interpretation of the data. To address the challenges associated with glycan analysis, we developed a streamlined analytical solution that covers the entire process from sample preparation to data analysis. In this communication, we describe the complete analytical solution that begins with a simplified and fast N-linked glycan sample preparation protocol that can be completed in less than 1 hr. The sample preparation includes labelling with RapiFluor-MS tag to improve both fluorescence (FLR) and mass spectral (MS) sensitivities. Following HILIC-UPLC/FLR/MS analyses, the data are processed and a library search based on glucose units has been included to expedite the task of structural assignment. We then applied this total analytical solution to characterize the glycosylation of the NIST Reference Material mAb 8761. For this glycoprotein, we confidently identified 35 N-linked glycans and all three major classes, high mannose, complex, and hybrid, were present. The majority of the glycans were neutral and fucosylated; glycans featuring N-glycolylneuraminic acid and those with two galactoses connected via an α1,3-linkage were also identified.

Marrying project deliverability models and labour supply for the oil sands

Energy Technology Data Exchange (ETDEWEB)

Albright, R.; Whitaker, C.A. [Fluor Canada Ltd., Calgary, AB (Canada)

2005-07-01

Alberta is predicting a labour shortage to support the construction and operation of planned oil sands projects in the region. This paper provided a framework of options available to stakeholders in addressing resource constraints from the viewpoint of Fluor Canada Ltd. A background of previous projects was presented, which highlighted various strategies used in the management of human resources issues. Strategies included local hiring through the Alberta-based trade unions; recruitment from other Canadian provinces; a higher ratio of apprentices; extremely high utilization crew schedules; and extended use of overtime. It was noted that these strategies resulted in some cost overruns and lower productivity levels. A productivity analysis was used to determine and resolve productivity issues. Various regulations in Alberta were discussed in relation to training programs and skilled immigrants. Various international training facilities operated by Fluor were reviewed. A factor model of human resources issues was presented. Summaries of supply chain management, systems, and technologies were presented. Issues concerning prefabrication, pre-assembly, modularization and offsite fabrication were discussed. It was concluded that by taking advantage of lessons learned in previous projects a solid foundation is set from which to plan for future requirements. Successful project execution is achieved by taking advantage of current technology; enhancing modular construction standards; and using supply chain management techniques and enhanced labour supply solutions. tabs., figs.

DESIGN OF A SYSTEM TO RETRIEVE SLUDGE FROM THE K EAST SPENT FUEL BASIN AT HANFORD

International Nuclear Information System (INIS)

Twitchell, A.L.; MacLean, G.T.; Ho, Q.T.; Fort, D.L.

2003-01-01

This paper describes the Sludge Retrieval System (SRS), which was designed to safely remove radioactive sludge from the K East spent fuel basin at the 100 K Area of the Hanford Site. Basin water and sludge have the potential to leak to the environment due to the age and condition of the basins. Since the 100 K Area spent fuel basins are located next to the Columbia River, the Spent Nuclear Fuel Project mission includes the safe removal, containment, and transportation of sludge from the basins to a secure storage location. The scope of the SRS includes: A system capable of retrieving sludge from the K East basin floor, pits, and fuel canisters; Separation of debris from sludge, where debris is defined as any material greater than 0.64 cm (0.25 in.) in diameter; Collection of sludge particles in a container that can be transported away from the basin; Modifications to the K East basin to allow installation of the SRS. The SRS was designed by Fluor Federal Services. Changes to the designed system were made by Fluor Hanford as a result of full-scale testing performed after design. This paper discusses this testing, as well as operation and control of the system. Construction and startup testing was initially scheduled to be complete by the end of December 2002. Startup of the system is now expected in April 2003

Effect of different concentrations of fluoride varnish on enamel surface microhardness: An in vitro randomized controlled study

Directory of Open Access Journals (Sweden)

Priya Subramaniam

2016-01-01

Full Text Available Introduction: Dental caries occurs as a result of demineralization-remineralization phases occurring alternately at the tooth surface. Fluoride varnishes have a caries-inhibiting effect on teeth through remineralization. The resulting enamel is resistant to acid dissolution. Aim: The aim of this study is to assess enamel surface microhardness (SMH following varnish application with different fluoride concentrations. Materials and Methods: Ninety freshly extracted, caries-free premolar teeth were used. Teeth were sectioned to obtain enamel blocks from the buccal surface of crown. The blocks were serially polished and flattened, embedded in acrylic blocks and smoothened to achieve a flat surface. The samples were divided into three groups, namely, A, B, and C consisting of 30 enamel blocks each. In Group A, Fluor Protector® varnish and in Group B, Bi-Fluorid 10® varnish was applied. Group C served as controls. All samples were subjected to a demineralization-remineralization cycle for 7 days. The SMH of enamel was measured. Data obtained was subjected to statistical analysis using the Student's t-test and one-way ANOVA. Results: The mean values of enamel SMH of Groups A and B were 496.99 ± 4.81 and 449.47 ± 7.37 Vickers Hardness Number, respectively. Conclusion: Fluor Protector varnish showed significantly higher enamel SMH than that of the other two groups (P < 0.05.

Repowering analysis: Hanford Generating Project (HGP), Task Order Number 6

International Nuclear Information System (INIS)

1988-12-01

The Hanford Generating Project (HGP), owned by the Washington Public Power Supply System, consists of two low pressure steam turbines, generators, and associated equipment located adjacent to the Department of Energy's (DOE) N-Reactor. HGP has been able to produce approximately 800 MWe with low pressure steam supplied by N-Reactor. DOE has placed N-Reactor in cold standby status for an undetermined length of time. This results in the idling of the HGP since no alternative source of steam is available. Bonneville Power Administration contracted with Fluor Daniel, Inc. to investigate the feasibility and cost of constructing a new source of steam for (repowering) one of the HGP turbines. The steam turbine is currently operated with 135 psia steam. The turbines can be rebuilt to operate with 500 psia steam pressure by adding additional stages, buckets, nozzles, and diaphragms. Because of the low pressure design, this turbine can never achieve the efficiencies possible in new high pressure turbines by the presences of existing equipment reduces the capital cost of a new generating resource. Five repowering options were investigated in this study. Three cases utilizing gas turbine combined cycle steam generation equipment, one case utilizing a gas fired boiler, and a case utilizing a coal fired boiler. This report presents Fluor Daniel's analysis of these repowering options

Study of the dry processing of uranium ores; Etude des traitements de minerais d'uranium par voie seche

Energy Technology Data Exchange (ETDEWEB)

Guillet, H

1959-02-01

A description is given of direct fluorination of pre-concentrated uranium ores in order to obtain the hexafluoride. After normal sulfuric acid treatment of the ore to eliminate silica, the uranium is precipitated by a load of lime to obtain: either impure calcium uranate of medium grade, or containing around 10% of uranium. This concentrate is dried in an inert atmosphere and then treated with a current of elementary fluorine. The uranium hexafluoride formed is condensed at the outlet of the reaction vessel and may be used either for reduction to tetrafluoride and the subsequent manufacture of uranium metal or as the initial product in a diffusion plant. (author) [French] Il s'agit d'une description de fluoration directe de preconcentres de minerais d'uranium en vue d'obtention d'hexafluorure. Apres attaque sulfurique normale du minerai, afin d' eliminer la silice, l' uranium est precipite par un toit de chaux pour obtenir: ou uranate de chaux impur de titre moyen, ou uranium de la dizaine du pourcentage. Ce concentre seche en atmosphere inerte est soumis a un courant de fluor elementaire. L'hexafluorure d'uranium forme est condense a la sortie du reacteur et peut etre utilise soit apres reduction en tetrafluorure par l'elaboration d'uranium metal, soit comme produit de base dans le cadre d'une usine de diffusion. (auteur)

SNF sludge treatment system preliminary project execution plan

International Nuclear Information System (INIS)

Flament, T.A.

1998-01-01

The Fluor Daniel Hanford, Inc. (FDH) Project Director for the Spent Nuclear Fuel (SNF) Project has requested Numatec Hanford Company (NHC) to define how Hanford would manage a new subproject to provide a process system to receive and chemically treat radioactive sludge currently stored in the 100 K Area fuel retention basins. The subproject, named the Sludge Treatment System (STS) Subproject, provides and operates facilities and equipment to chemically process K Basin sludge to meet Tank Waste Remediation System (TWRS) requirements. This document sets forth the NHC management approach for the STS Subproject and will comply with the requirements of the SNF Project Management Plan (HNF-SD-SNFPMP-011). This version of this document is intended to apply to the initial phase of the subproject and to evolve through subsequent revision to include all design, fabrication, and construction conducted on the project and the necessary management and engineering functions within the scope of the subproject. As Project Manager, NHC will perform those activities necessary to complete the STS Subproject within approved cost and schedule baselines and turn over to FDH facilities, systems, and documentation necessary for operation of the STS

The role of rare earth oxide nanoparticles in suppressing the photobleaching of fluorescent organic dyes

Science.gov (United States)

Guha, Anubhav; Basu, Anindita

2013-03-01

Organic dyes are widely used for both industrial as well as in scientific applications such as the fluorescent tagging of materials. However the process of photobleaching can rapidly degrade dye fluorescence rendering the material non-functional. Thus exploring novel methods for preventing photobleaching can have widespread benefits. In this work we show that the addition of minute quantities of rare earth (RE) oxide nanoparticles can significantly suppress the photobleaching of dyes. The fluorescence of Rhodamine and AlexaFluor dyes was measured as a function of time with and without the addition of CeO2 and La2O3 nanoparticle additives (two RE oxides that contain an oxygen vacancy based defect structure), as well as with FeO nanoparticles (which has an oxygen excess stoichiometry). We find that the rare earth oxides significantly prolonged the lifetimes of the dyes. The results allow us to develop a model based upon the presence of oxygen vacancies defects that allow the RE oxides to act as oxygen scavengers. This enables the RE oxide particles to effectively remove reactive oxygen free radicals generated in the dye solutions during the photoabsorption process. Current affiliation: Harvard University

PALS investigations of free volumes thermal expansion of J-PET plastic scintillator synthesized in polystyrene matrix

Directory of Open Access Journals (Sweden)

Wieczorek Anna

2015-12-01

Full Text Available The polystyrene doped with 2,5-diphenyloxazole as a primary fluor and 2-(4-styrylphenylbenzoxazole as a wavelength shifter prepared as a plastic scintillator was investigated using positronium probe in wide range of temperatures from 123 to 423 K. Three structural transitions at 260, 283, and 370 K were found in the material. In the o-Ps intensity dependence on temperature, the significant hysteresis is observed. Heated to 370 K, the material exhibits the o-Ps intensity variations in time.

Uranium deposit of Bauzot (Saone et Loire)

International Nuclear Information System (INIS)

Carrat, G.H.

1956-01-01

The best known of the uranium ore deposits of the Morvan (a province of France) is in the form of a bundle of quartz-fluor lodes with pitchblende and B.P.G.C. ore. The pitchblende seems to have been deposited at different time in respect to the formation of the gangue minerals, but generally it is ore of the first-formed. The main concentrations of ore are always in the vicinity of dykes of basic crystalline rocks. (author) [fr

Evaluation and Assessment of Fluoride in Drinking Water Wells Damavand Villages Zoning in GIS According to DMF Index

OpenAIRE

Kave Kheirkhah Rahimabad; Amir Hessam Hasani; Reza Saeedi; Mir Masoud Kheirkhah Zarkesh; Mojtaba Sayadi

2016-01-01

Background:Fluoride is one the vital anions and the drinking water is the main source of preparing it for the human body. Nonetheless, the aim of this paper is to investigate the Fluoride rate in water supplying wells by using GIS environment according to decay, missing or filled (DMF) index.  Methods: This research is an analytic and cross-sectional descriptive study with sampling approach of 12 water supplying wells of Damavand villages in summer and autumn the year 2013. The Fluor...

Immobilized low-level waste disposal options configuration study

International Nuclear Information System (INIS)

Mitchell, D.E.

1995-02-01

This report compiles information that supports the eventual conceptual and definitive design of a disposal facility for immobilized low-level waste. The report includes the results of a joint Westinghouse/Fluor Daniel Inc. evaluation of trade-offs for glass manufacturing and product (waste form) disposal. Though recommendations for the preferred manufacturing and disposal option for low-level waste are outside the scope of this document, relative ranking as applied to facility complexity, safety, remote operation concepts and ease of retrieval are addressed

Label Free Chromosome Translocation Detection with Silicon nanowires

DEFF Research Database (Denmark)

Kwasny, Dorota; Andersen, Karsten Brandt; Frøhling, Kasper Bayer

HROMOSOME translocation, which is a rearrangement of arms between two chromosomes, is a major group of chromosome abnormalities leading to cancer. As a result, two derivative chromosomes with sequences coming from both chromosomes are formed. The current translocation detection method is a Fluore......HROMOSOME translocation, which is a rearrangement of arms between two chromosomes, is a major group of chromosome abnormalities leading to cancer. As a result, two derivative chromosomes with sequences coming from both chromosomes are formed. The current translocation detection method...

Apparent light requirement for activation of photosynthesis upon rehydration of desiccated beachrock microbial mats

DEFF Research Database (Denmark)

Schreiber, Ulrich; Gademann, Rolf; Bird, Paul

2002-01-01

. Parallel measurements of O2 concentration with an oxygen microoptode revealed zero oxygen concentration in the surface layer of rehydrated beachrock in the dark. Upon illumination, O2 concentration increased in parallel with PSII quantum yield and decreased again to zero in the dark. It is proposed......, emitter-detector unit; Fo, fluor-escence yield of dark-adapted sample; Fm, maximal fluorescence yield measured during saturation pulse; Fv, variable fluorescence yield; LED, light-emitting diode; PAM, pulse amplitude modulation; PQ, plastoquinone...

Recovery of fluoride ion selective electrode

International Nuclear Information System (INIS)

Monteiro, R.P.G.

1988-01-01

A recovery procedure of fluoride ion selective electrode based upon the body radiography of inactive electrode and introduction of suitable internal regeneration solution, is developed. The recovered electrode was tested in standard solutions of fluoride ions (10 sup5) to 10 -1M showing as good performance as the new one. The fluor determination by potentiometric measurements with selective electrode is used in nuclear fuel cycle for quality control of thorium and uranium mixed oxide pellets and pellets of uranium dioxides. (author) [pt

PROGRESS WITH K BASINS SLUDGE RETRIEVAL STABILIZATION & PACKAGING AT THE HANFORD NUCLEAR SITE

Energy Technology Data Exchange (ETDEWEB)

KNOLLMEYER, P.M.; PHILLIPS, C; TOWNSON, P.S.

2006-01-30

This paper shows how Fluor Hanford and BNG America have combined nuclear plant skills from the U.S. and the U.K. to devise methods to retrieve and treat the sludge that has accumulated in K Basins at the Hanford Site over many years. Retrieving the sludge is the final stage in removing fuel and sludge from the basins to allow them to be decontaminated and decommissioned, so as to remove the threat of contamination of the Columbia River. A description is given of sludge retrieval using vacuum lances and specially developed nozzles and pumps into Consolidation Containers within the basins. The special attention that had to be paid to the heat generation and potential criticality issues with the irradiated uranium-containing sludge is described. The processes developed to re-mobilize the sludge from the Consolidation Containers and pump it through flexible and transportable hose-in-hose piping to the treatment facility are explained with particular note made of dealing with the abrasive nature of the sludge. The treatment facility, housed in an existing Hanford building, is described, and the uranium-corrosion and grout packaging processes explained. The uranium corrosion process is a robust, tempered process very suitable for dealing with a range of differing sludge compositions. Optimization and simplification of the original sludge corrosion process design is described and the use of transportable and reusable equipment is indicated. The processes and techniques described in the paper are shown to have wide applicability to nuclear cleanup.

Synthèse et caractérisation de composés fluorés pour le piégeage de fluorures gazeux

OpenAIRE

Clarenc , Romain Pierre

2010-01-01

This work deals with the synthesis and characterization of alkali, alkali-earth and rare earthbased fluorides and the reactivity of the latter with ReF6 for UF6 purification. In a first part,we focused our attention on the synthesis of KMgF3, MgF2 and CaF2 high surface area metalfluorides coupling both microwave assisted solvothermal process and a fluorination step withelemental fluorine (F2). The higher the surface area, the higher the oxygen rate. Thesenanofluorides exhibit Lewis basic char...

User Manual for the AZ-101 Data Acquisition System (AS-101 DAS)

Energy Technology Data Exchange (ETDEWEB)

BRAYTON, D.D.

2000-02-17

User manual for the TK AZ-101 Waste Retrieval System Data Acquisition System. The purpose of this document is to describe use of the AZ-101 Data Acquisition System (AZ-101 DAS). The AZ-101 DAS is provided to fulfill the requirements for data collection and monitoring as defined in Letters of Instruction (LOI) from Numatec Hanford Corporation (NHC) to Fluor Federal Services (FFS). For a complete description of the system, including design, please refer to the AZ-101 DAS System Description document, RPP-5572.

User Manual for the AZ-101 Data Acquisition System (AS-101 DAS)

International Nuclear Information System (INIS)

BRAYTON, D.D.

2000-01-01

User manual for the TK AZ-101 Waste Retrieval System Data Acquisition System. The purpose of this document is to describe use of the AZ-101 Data Acquisition System (AZ-101 DAS). The AZ-101 DAS is provided to fulfill the requirements for data collection and monitoring as defined in Letters of Instruction (LOI) from Numatec Hanford Corporation (NHC) to Fluor Federal Services (FFS). For a complete description of the system, including design, please refer to the AZ-101 DAS System Description document, RPP-5572

Resistência à microtração entre uma cerâmica hidrotérmica, silanizada ou não, aderida à uma resina composta por um cimento resinoso

OpenAIRE

Lopes, Angela; Leite, Fabiola; Valandro, Luis Felipe; Siqueira, Luciana; Pimenta, Luiz André; Neisser, Maximiliano Piero

2010-01-01

Esse trabalho teve como objetivo avaliar a resistência adesiva entre uma cerâmica hidrotérmica (Symbio ceram, Degussa), silanizada ou não e aderida à uma resina composta (Filtec Z100- 3M ESPE) por um cimento resinoso (Panavia F, Kuraray). Foram confeccionados 2 blocos, divididos em 2 grupos assim constituídos: Grupo I-tratamento de superfície da cerâmica com ácido fluorídrico a 10% e união a um substrato (resina compost...

An evaluation of the management system verification pilot at Hanford

International Nuclear Information System (INIS)

Briggs, C.R.; Ramonas, L.; Westendorf, W.

1998-01-01

The Chemical Management System (CMS), currently under development at Hanford, was used as the ''test program'' for pilot testing the value added aspects of the Chemical Manufacturers Association's (CMA) Management Systems Verification (MSV) process. The MSV process, which was developed by CMA's member chemical companies specifically as a tool to assist in the continuous improvement of environment, safety and health (ESH) performance, represents a commercial sector ''best practice'' for evaluating ESH management systems. The primary purpose of Hanford's MSV Pilot was to evaluate the applicability and utility of the MSV process in the Department of Energy (DOE) environment. However, because the Integrated Safety Management System (ISMS) is the framework for ESH management at Hanford and at all DOE sites, the pilot specifically considered the MSV process in the context of a possible future adjunct to Integrated Safety Management System Verification (ISMSV) efforts at Hanford and elsewhere within the DOE complex. The pilot involved the conduct of two-hour interviews with four separate panels of individuals with functional responsibilities related to the CMS including the Department of Energy Richland Operations (DOE-RL), Fluor Daniel Hanford (FDH) and FDH's major subcontractors (MSCS). A semi-structured interview process was employed by the team of three ''verifiers'' who directed open-ended questions to the panels regarding the development, integration and effectiveness of management systems necessary to ensure the sustainability of the CMS effort. An ''MSV Pilot Effectiveness Survey'' also was completed by each panel participant immediately following the interview

The influence of additional fluors on the retention ability of dough and the technological quality of bakery products

Directory of Open Access Journals (Sweden)

Tatiana Bojňanská

2015-08-01

Full Text Available The work monitored rheofermentation properties of dough prepared from composite flours formed by 70% of wheat flour T650 and the addition of 30%. Three kinds of additions were used, namely spelt flour, amaranth flour and buckwheat flour. To determine rheofermentation properties Rheofermentometer Rhea F4 was used, by means of which the dough development, the production of fermentation gases, retention ability of dough and the activity of used baking yeast were analysed. The best ability to retain formed fermentation gas had wheat flour (control and composite flour with the addition of spelt flour. The composite flour with addition of amaranth flour showed a retention coefficient compared to the control lower by 13%, and the composite flour with addition of buckwheat flour showed a retention coefficient compared to the control reduced by 20%. Control flour and composite flours were then processed in the baking experiment. Based on its results it was possible to evaluate the effect of the addition and retention capacity of dough on the quality of the final products (experimental loaves. The biggest loaf volume (200 cm3 and the optimal vaulting (0.65 were found in the control and a loaf made of composite flour with addition of spelt. Loaf volume, produced from composite flours with the addition of amaranth, and buckwheat was compared to control lower by 18.7%, and 16.3% respectively. The value of vaulting of these products (0.40 can be evaluated as unsatisfactory. Based on the evaluation of results observed by measuring on the rheofermentometer and baking experiment results it can be concluded that a better ability to retain the formed fermentation gas, thus ensuring high volume, had loaves made from wheat flour T650 and composite flour with addition of spelt flour. Based on the findings, it is possible to state that the results of rheofermentometric measurements predict the volume and vaulting of bakery products. By means of Rheofermentometer

Design of a System to Retrieve Sludge from the K East Spent Fuel Basin at Hanford

International Nuclear Information System (INIS)

TWITCHELL, A.L.

2003-01-01

This paper describes the Sludge Retrieval System (SRS), which was designed to safely remove radioactive sludge from the K East spent fuel basin at the 100 K Area of the Hanford Site. Basin water and sludge have the potential to leak to the environment due to the age and condition of the basins. Since the 100 K Area spent fuel basins are located next to the Columbia River, the Spent Nuclear Fuel Project mission includes the safe removal, containment, and transportation of sludge from the basins to a secure storage location. The scope of the SRS includes: (1) a system capable of retrieving sludge from the K East basin floor, pits, and fuel canisters; (2) separation of debris from sludge, where debris is defined as any material greater than 0.64 cm (0.25 in.) in diameter; (3) collection of sludge particles in a container that can be transported away from the basin; and (4) modifications to the K East basin to allow installation of the SRS. The SRS was designed by Fluor Federal Services. Changes to the designed system were made by Fluor Hanford as a result of full-scale testing performed after design. This paper discusses this testing, as well as operation and control of the system. Construction and startup testing was initially scheduled to be complete by the end of December 2002. Startup of the system is now expected in April 2003

Anticalculus efficacy of a new dentifrice.

Science.gov (United States)

Llena, Carmen; Forner, Leopoldo; Vento, Cristina

2009-06-01

The Volpe and Manhold Index (VMI) was used to evaluate the anticalculus efficacy of the dentifrice Fluor Kin antisarro, used on adults twice a day for 2 minutes over 3 months, in comparison with the dentifrice Lacer. A clinical study in which 48 adults took part was designed. The presence of calculus was determined at baseline (VMI), a tartrectomy was performed, and the patients were instructed to brush their teeth twice a day for 2 minutes, using a medium-bristled toothbrush with a commercial dentifrice containing 0.2% aldioxa and 1.9% sodium monofluorophosphate. Three months later, VMI was determined again. After 2 weeks, a new tartrectomy was performed on the same patients, and the subjects were instructed to brush their teeth as before, this time with the study dentifrice based on 0.32% sodium fluoride, 4.1% tetrapotassium pyrophosphate, 2.0% PVM/MA (methylvinylether/maleic acid) copolymer (Gantrez S), 1.0% provitamin B5, and 0.2% vitamin B3. After an additional 3 months, dental calculus was determined again. The study dentifrice showed a significant reduction in VMI in relation to the initial situation (P = .009). There were also significant differences in VMI values between the 2 dentifrices (P = .010). VMI differences were not significant for either dentifrice when analyzed by gender, tobacco use, and toothbrushing frequency before starting the study. Brushing twice a day for 2 minutes with Fluor Kin antisarro effectively reduces supragingival calculus.

A fluorescence resonance energy transfer-based approach for investigating late endosome-lysosome retrograde fusion events.

Science.gov (United States)

Kaufmann, A M; Goldman, S D B; Krise, J P

2009-03-01

Traditionally, lysosomes have been considered to be a terminal endocytic compartment. Recent studies suggest that lysosomes are quite dynamic, being able to fuse with other late endocytic compartments as well as with the plasma membrane. Here we describe a quantitative fluorescence energy transfer (FRET)-based method for assessing rates of retrograde fusion between terminal lysosomes and late endosomes in living cells. Late endosomes were specifically labeled with 800-nm latex beads that were conjugated with streptavidin and Alexa Fluor 555 (FRET donor). Terminal lysosomes were specifically labeled with 10,000-MW dextran polymers conjugated with biotin and Alexa Fluor 647 (FRET acceptor). Following late endosome-lysosome fusion, the strong binding affinity between streptavidin and biotin brought the donor and acceptor fluorophore molecules into close proximity, thereby facilitating the appearance of a FRET emission signal. Because apparent size restrictions in the endocytic pathway do not permit endocytosed latex beads from reaching terminal lysosomes in an anterograde fashion, the appearance of the FRET signal is consistent with retrograde transport of lysosomal cargo back to late endosomes. We assessed the efficiency of this transport step in fibroblasts affected by different lysosome storage disorders-Niemann-Pick type C, mucolipidosis type IV, and Sandhoff's disease, all of which have a similar lysosomal lipid accumulation phenotype. We report here, for the first time, that these disorders can be distinguished by their rate of transfer of lysosome cargos to late endosomes, and we discuss the implications of these findings for developing new therapeutic strategies.

Intrinsic Pleckstrin Homology (PH) Domain Motion in Phospholipase C-β Exposes a Gβγ Protein Binding Site*

OpenAIRE

Kadamur, Ganesh; Ross, Elliott M.

2016-01-01

Mammalian phospholipase C-β (PLC-β) isoforms are stimulated by heterotrimeric G protein subunits and members of the Rho GTPase family of small G proteins. Although recent structural studies showed how Gαq and Rac1 bind PLC-β, there is a lack of consensus regarding the Gβγ binding site in PLC-β. Using FRET between cerulean fluorescent protein-labeled Gβγ and the Alexa Fluor 594-labeled PLC-β pleckstrin homology (PH) domain, we demonstrate that the PH domain is the minimal Gβγ binding region in...

Fiber optic neutron imaging system: calibration

International Nuclear Information System (INIS)

Malone, R.M.; Gow, C.E.; Thayer, D.R.

1981-01-01

Two neutron imaging experiments using fiber optics have been performed at the Nevada Test Site. In each experiment, an array of scintillator fluor tubes is exposed to neutrons. Light is coupled out through radiation resistant PCS fibers (8-m long) into high-bandwidth, graded index fibers. For image reconstruction to be accurate, common timing differences and transmission variations between fiber optic channels are needed. The calibration system featured a scanning pulsed dye laser, a specially designed fiber optic star coupler, a tektronix 7912AD transient digitizer, and a DEC PDP 11/34 computing system

Canister storage building trade study. Final report

International Nuclear Information System (INIS)

Swenson, C.E.

1995-05-01

This study was performed to evaluate the impact of several technical issues related to the usage of the Canister Storage Building (CSB) to safely stage and store N-Reactor spent fuel currently located at K-Basin 100KW and 100KE. Each technical issue formed the basis for an individual trade study used to develop the ROM cost and schedule estimates. The study used concept 2D from the Fluor prepared ''Staging and Storage Facility (SSF) Feasibility Report'' as the basis for development of the individual trade studies

Canister storage building trade study. Final report

Energy Technology Data Exchange (ETDEWEB)

Swenson, C.E. [Westinghouse Hanford Co., Richland, WA (United States)

1995-05-01

This study was performed to evaluate the impact of several technical issues related to the usage of the Canister Storage Building (CSB) to safely stage and store N-Reactor spent fuel currently located at K-Basin 100KW and 100KE. Each technical issue formed the basis for an individual trade study used to develop the ROM cost and schedule estimates. The study used concept 2D from the Fluor prepared ``Staging and Storage Facility (SSF) Feasibility Report`` as the basis for development of the individual trade studies.

Developments in the LASL Fuel Pin Imaging System: PINEX-3A

International Nuclear Information System (INIS)

Lumpkin, A.H.; Berzins, G.J.; Cosimi, R.A.; O'Hare, T.E.; Davidson, J.R.

1979-01-01

The LASL Fuel Pin Imaging System was evaluated using a series of 10 TREAT transients, each of approx. 240-MW peak power. HEDL provided the fuel-ejection type capsule with annular fuel pellets. The pin visibility threshold was determined to be approx. 20-MW of TREAT power (approx. 130 W/g), almost an order of magnitude improvement over our PINEX-2 threshold. The impact of changes in instrumentation, imaging apertures, and fluors that produced the improved sensitivity are reported. Results of a time-integrated imaging technique are also presented

Influencia de los tratamientos microabrasivos sobre la resistencia adhesiva en dientes con fluorosis

OpenAIRE

Paola Mena Silva; Ana del Carmen Armas

2015-01-01

La búsqueda de tratamientos mínimamente invasivos y altamente estéticos para pacientes con fluorosis, ha llevado a buscar mecanismos para solucionar esta problemática, mediante la utilización de resinas como la primera opción. Sin embargo el principal problema del tratamiento, se centra en la poca adhesión debido a las características estructurales del esmalte fluorótico, en grados de fluorosis TF 1 al 3, el ácido no actúa correctamente, causando ausencia de grabado principalmente entre las e...

Utility of FDG-PET in neuropediatric pathology; Utilidad del PET-FDG en patologia neuropediatrica

Energy Technology Data Exchange (ETDEWEB)

Massardo, Teresa V; Canessa G, Jose; Sierralta C, M. Paulina; Gonzalez E, Pstricio; Jofre M, M. Josefina [Centro PET Imagenes Moleculares Hospital Militar de Santiago (Chile)

2007-07-01

Due to the recent incorporation of positron technology (PET) it appears interesting to review the present indications of fluor-deoxyglucose (FDG) in neuropediatric pathology. The main indication is in the evaluation of refractory epilepsy mainly in cases with negative magnetic resonance or discordance with electroencephalography Some uses in tumors are also discussed, such as tumor characterization and differentiation between radionecrosis and recurrence. The experience between years 2003 and 2007 at the Santiago Military Hospital, using FDG in 66 children and adolescents cases with diverse neurological indications was reviewed.

Usefulness of PET-FDG in pathology neuropediatric; Utilidad del PET-FDG en patologia neuropediatrica

Energy Technology Data Exchange (ETDEWEB)

Massardo V, Teresa; Canessa G, Jose; Sierralta C, M Paulina; Gonzalez E, Patricio; Jofre M, M Josefina [Centro PET Imagenes Moleculares Hospital Militar de Santiago, Santiago (Chile)

2007-07-01

Due to the recent incorporation of positron technology (PET) it appears interesting to review the present indications of fluor-deoxyglucose (FDG) in neuropediatric pathology. The main indication is in the evaluation of refractory epilepsy mainly in cases with negative magnetic resonance or discordance with electro encephalography Some uses in tumors are also discussed, such as tumor characterization and differentiation between radio necrosis and recurrence. The experience between years 2003 and 2007 at the Santiago Military Hospital, using FDG in 66 children and adolescents cases with diverse neurological indications was reviewed (au)

Usefulness of PET-FDG in pathology neuropediatric

International Nuclear Information System (INIS)

Massardo V, Teresa; Canessa G, Jose; Sierralta C, M.Paulina; Gonzalez E, Patricio; Jofre M, M.Josefina

2007-01-01

Due to the recent incorporation of positron technology (PET) it appears interesting to review the present indications of fluor-deoxyglucose (FDG) in neuropediatric pathology. The main indication is in the evaluation of refractory epilepsy mainly in cases with negative magnetic resonance or discordance with electro encephalography Some uses in tumors are also discussed, such as tumor characterization and differentiation between radio necrosis and recurrence. The experience between years 2003 and 2007 at the Santiago Military Hospital, using FDG in 66 children and adolescents cases with diverse neurological indications was reviewed (au)

Verification report for SIMREP 1.1

International Nuclear Information System (INIS)

Tarapore, P.S.

1987-06-01

SIMREP 1.1 is a discrete event computer simulation of repository operations in the surface waste-handling facility. The logic for this model is provided by Fluor Technology, Inc., the Architect/Engineer of the salt repository. The verification methods included a line-by-line review of the code, a detailed examination of a generated trace of all simulated events over a given period of operations, and a comparison of the simulation output results with expected values. SIMREP 1.1 performs in the required manner under the given range of input conditions

PPO-ethanol system as wavelength shifter for the Cherenkov counting technique using a liquid scintillation counter

International Nuclear Information System (INIS)

Takiue, M.; Fujii, H.; Ishikawa, H.

1984-01-01

2,5-diphenyloxazole (PPO) has been proposed as a wavelength shifter for Cherenkov counting. Since PPO is not incorporated with water, we have introduced the fluor into water in the form of micelle using a PPO-ethanol system. This technique makes it possible to obtain a high Cherenkov counting efficiency under stable sample conditions, attributed to the proper spectrometric features of the PPO. The 32 P Cherenkov counting efficiency (68.4%) obtained from this technique is 1.62 times as large as that measured with a conventional Cherenkov technique. (orig.)

Immediately lower emissions and often also lower energy demand. Exchange of refrigerants with only reduced technical expenditure; Sofort weniger Emissionen und oft auch weniger Energiebedarf. Kaeltemittelaustausch mit nur wenigen technischem Aufwand

Energy Technology Data Exchange (ETDEWEB)

Corr, Stuart; Cooper, Martyn [Mexichem Fluor, Runcorn (United Kingdom); Schwennesen, Karsten [Mexichem Fluor, Frankfurt am Main (Germany)

2012-11-15

The refrigeration industry as well as the air conditioning industry face again the challenges in the selection of refrigerants. The keyword here is Global Warming Potential (GWP). The search for the best solution for the future is already in full swing. But, can you do something already today? Yes, you can. A simple exchange of refrigerants with an enhanced GWP value such as R404A against a refrigerant with a lower GWP value such as KLEA407A from Mexichem Fluor can reduce the environmental impact immediately.

Measurement of detector neutron energy response using time-of-flight techniques

International Nuclear Information System (INIS)

Janee, H.S.

1973-09-01

The feasibility of using time-of-flight techniques at the EG and G/AEC linear accelerator for measuring the neutron response of relatively sensitive detectors over the energy range 0.5 to 14 MeV has been demonstrated. The measurement technique is described in detail as are the results of neutron spectrum measurements from beryllium and uranium photoneutron targets. The sensitivity of a fluor photomultiplier LASL detector with a 2- by 1-inch NE-111 scintillator was determined with the two targets, and agreement in the region of overlap was very good. (U.S.)

Detailed design data package: 3.1a-Film cooler pressure drop data; Item 3.2a - SBS packing selection; Item 3.2b, 3.2c - Pressure drop data for SBS distribution plate; and Item 3.2e - SBS distribution plate and liquid risers. PHTD pilot-scale melter testing system cost account milesonte 1.2.2.04.15A

International Nuclear Information System (INIS)

Whyatt, G.A.; Anderson, L.D.; Evans, J. II.

1996-03-01

This data package transmits information collected on the Liquid-Fed Ceramic Melter (LFCM) offgas system prior to melter feeding operations. Injection of steam to the melter plenum was used to simulate feeding of the melter. Steam surge cases were studied under steady-state surge conditions. Dynamic surges will be examined under data needs. The Fluor data needs included two blank tables requesting specific information for data needs 3.1 and 3.2. These tables are provided in Tables S.1 and S.2 below with the requested information filled in

Proteomics analysis of the endogenous, constitutive, leaf SUMOylome.

Science.gov (United States)

Colignon, Bertrand; Delaive, Edouard; Dieu, Marc; Demazy, Catherine; Muhovski, Yordan; Wallon, Cindy; Raes, Martine; Mauro, Sergio

2017-01-06

SUMOylation is a post-translational modification which regulates a number of critical biological processes in, for example mammals, yeast and plants. In order to fully understand the functional effects of SUMOylation an essential first step is the identification of endogenous targets for SUMOylation. Here we report the results of using a recently developed proteomic approach based on the use of 3D gels to identify the endogenous SUMO targets in leaves of Solanum tuberosum. By using 3D gels we avoid the problem of co-migration of proteins, which is a major limitation of 2D gels, and we enable the use of the highly sensitive CyDye DIGE fluor saturation dyes. Using this new method we have identified 39 individual proteins as probable SUMO targets in leaves of Solanum tuberosum. The advantages of this method compared with other approaches are discussed, and possible future developments are outlined. The authors have no conflicts of interest to declare. All authors have approved the manuscript and agree with submission to Journal of Proteomics. Copyright © 2016. Published by Elsevier B.V.

Fernald restoration: ecologists and engineers integrate restoration and cleanup

Energy Technology Data Exchange (ETDEWEB)

Woods, Eric; Homer, John

2002-07-15

As cleanup workers excavate pits and tear down buildings at the Fernald site in southwest Ohio, site ecologists are working side-by-side to create thriving wetlands and develop the early stages of forest, prairie, and savanna ecosystems to restore natural resources that were impacted by years of site operations. In 1998, the U.S. Department of Energy-Fernald Office (DOE-FN) and its cleanup contractor, Fluor Fernald, Inc., initiated several ecological restoration projects in perimeter areas of the site (e.g., areas not used for or impacted by uranium processing or waste management). The projects are part of Fernald's final land use plan to restore natural resources over 904 acres of the 1,050-acre site. Pete Yerace, the DOE-FN Natural Resource Trustee representative is working with the Fernald Natural Resource Trustees in an oversight role to resolve the state of Ohio's 1986 claim against DOE for injuries to natural resources. Fluor Fernald, Inc., and DOE-FN developed the ''Natural Resource Restoration Plan'', which outlines 15 major restoration projects for the site and will restore injured natural resources at the site. In general, Fernald's plan includes grading to maximize the formation of wetlands or expanded floodplain, amending soil where topsoil has been removed during excavation, and establishing native vegetation throughout the site. Today, with cleanup over 35 percent complete and site closure targeted for 2006, Fernald is entering a new phase of restoration that involves heavily remediated areas. By working closely with engineers and cleanup crews, site ecologists can take advantage of remediation fieldwork (e.g., convert an excavated depression into a wetland) and avoid unnecessary costs and duplication. This collaboration has also created opportunities for relatively simple and inexpensive restoration of areas that were discovered during ongoing remediation. To ensure the survival of the plant material in heavily

Bio-Based Coatings for Paper Applications

Directory of Open Access Journals (Sweden)

Vibhore Kumar Rastogi

2015-11-01

Full Text Available The barrier resistance and wettability of papers are commonly controlled by the application of petroleum-based derivatives such as polyethylene, waxes and/or fluor- derivatives as coating. While surface hydrophobicity is improved by employing these polymers, they have become disfavored due to limitations in fossil-oil resources, poor recyclability, and environmental concerns on generated waste with lack of biodegradation. Alternatively, biopolymers including polysaccharides, proteins, lipids and polyesters can be used to formulate new pathways for fully bio-based paper coatings. However, difficulties in processing of most biopolymers may arise due to hydrophilicity, crystallization behavior, brittleness or melt instabilities that hinder a full exploitation at industrial scale. Therefore, blending with other biopolymers, plasticizers and compatibilizers is advantageous to improve the coating performance. In this paper, an overview of barrier properties and processing of bio-based polymers and their composites as paper coating will be discussed. In particular, recent technical advances in nanotechnological routes for bio-based nano- composite coatings will be summarized, including the use of biopolymer nanoparticles, or nanofillers such as nanoclay and nanocellulose. The combination of biopolymers along with surface modification of nanofillers can be used to create hierarchical structures that enhance hydrophobicity, complete barrier protection and functionalities of coated papers.

PENGGUNAAN SILVER DIAMINA FLUORIDA (SDF 38% SEBAGAI Arresting Caries Treatment (ACT PADA ANAK-ANAK

Directory of Open Access Journals (Sweden)

Lendrawati Lendrawati

2011-09-01

Full Text Available AbstrakKaries merupakan masalah kesehatan gigi yang banyak diderita oleh anak-anak seluruh dunia terutama negara berkembang termasuk Indonesia. Kerusakan gigi pada anak-anak terjadi lebih cepat dibandingkan orang dewasa karena gigi yang baru erupsi masih dalam proses maturasi dan proses mineralisasi belum sempurna. Tubuli dentin anak anak yang masih lebar menyebabkan pembentukan jaringan sklerotik tidak sempurna dan buffer saliva masih kurang sehingga aktivitas proteolitik menjadi lebih banyak di dalam mulut. Fluor merupakan zat mineral yang digunakan sebagai bahan yang efektif mencegah terjadinya karies gigi dapat membuat lapisan email tahan terhadap kerusakan yang disebabkan pelarutan email oleh zat asam. Strategi pencegahan karies lebih efektif sejak diperkenalkannya silver diamina fluoride (SDF yang merupakan cairan tidak berwarna mengandung ion fluoride yang digunakan untuk memacu terjadinya proses remineralisasi hidoksiapatit mineral gigi. Penggunaan SDF ini merupakan metoda Arresting Caries Treatment (ACT. SDF menggabungkan efek penguatan gigi dari natrium fluoride (NaF dan efek nitrat perak.Konsentrasi efektif solusi SDF 38% (44.800 ion fluoride ppm digunakan untuk menghambat perkembangan karies pada gigi sulung anak-anak, terutama anak-anak yang sulit untuk dilakukan perawatan. SDF sederhana, mudah dalam mengaplikasikan dan biaya pemakaian lebih murah. SDF merupakan bahan yang tepat untuk digunakan untuk mengatasi masalah kesehatan gigi masyarakat terutama pada anak-anak.Kata Kunci : karies gigi, silver diamine fluoride, Arresting Caries Treatment, topikalAbstractDental caries is a health problem that affects many children all over the world, especially in developing countries, including Indonesia. Tooth decay in children occurs more rapidly than adults because the new tooth eruption is still in the process of maturation and mineralization process is not perfect. Dentin tubules of children is still wide lead sclerotic tissue formation

Rapid quantitative assay for chloramphenicol acetyltransferase

International Nuclear Information System (INIS)

Neumann, J.R.; Morency, C.A.; Russian, K.O.

1987-01-01

Measuring the expression of exogenous genetic material in mammalian cells is commonly done by fusing the DNA of interest to a gene encoding an easily-detected enzyme. Chloramphenicol acetyltransferase(CAT) is a convenient marker because it is not normally found in eukaryotes. CAT activity has usually been detected using a thin-layer chromatographic separation followed by autoradiography. An organic solvent extraction-based method for CAT detection has also been described, as well as a procedure utilizing HPLC analysis. Building on the extraction technique, they developed a rapid sensitive kinetic method for measuring CAT activity in cell homogenates. The method exploits the differential organic solubility of the substrate ([ 3 H] or [ 14 C]acetyl CoA) and the product (labeled acetylchloramphenicol). The assay is a simple one-vial, two-phase procedure and requires no tedious manipulations after the initial setup. Briefly, a 0.25 ml reaction with 100mM Tris-HCL, 1mM chloramphenicol, 0.1mM [ 14 C]acetyl CoA and variable amounts of cell homogenate is pipetted into a miniscintillation vial, overlaid with 5 ml of a water-immiscible fluor, and incubated at 37 0 C. At suitable intervals the vial is counted and the CAT level is quantitatively determined as the rate of increase in counts/min of the labeled product as it diffuses into the fluor phase, compared to a standard curve. When used to measure CAT in transfected Balb 3T3 cells the method correlated well with the other techniques

Preparation, installation, and calibration of a 152-fiber imaging experiment at the Nevada Test Site

International Nuclear Information System (INIS)

Thayer, D.R.; Lyons, P.B.; Looney, L.D.; Manning, J.P.; Malone, R.M.

1981-01-01

Fiber-optic transmission lines are being used with increasing frequency in the demanding environment of nuclear device diagnostic tests at the Nevada Test Site. Previous reports have described diagnostic experiments that utilize properties of fiber-optic cables to provide capabilities that are extremely difficult to obtain with coaxial cable systems. This paper describes an imaging experiment conducted during the last quarter of 1980 at the Nevada Test Site involving 152 approx. 0.6-km long GI fibers in 18 cables. An imager cell sensitive to neutron and gamma radiation was located at approx. 8 m from the source. Individual elements of the fluor were coupled by approx. 10 m PCS fibers (for radiation damage resistance) to the GI fibers used for the uphole and surface lines to the detector station. Light from the imager cell in a 9-nm band, centered at 540 nm, was detected by photomultipliers and the electrical signals then recorded on oscilloscopes. Overall system bandwidth, including the fluor, was approx. 80 MHz. Due to the complexity of the experiment and the conditions associated with field testing, the PCS and GI fibers were cut and terminated under laboratory shop conditions prior to installation at the field site. Procedures used for quality assurance of the fiber assemblies as well as procedures used in checking fiber throughput during installation are described. The application of a large star coupler (5 input x 200 output fibers) used for system time and amplitude calibration and an attempt to shutter fibers with neutrons for a multiplexing application are also discussed

Fracture load of different crown systems on zirconia implant abutments.

Science.gov (United States)

Albrecht, T; Kirsten, A; Kappert, H F; Fischer, H

2011-03-01

The purpose of this study was to evaluate the fracture load of single zirconia abutment restorations using different veneering techniques and materials. The abutment restorations were divided into 6 groups with 20 samples each: test abutments (control group A), lithium disilicate ceramic crowns bonded on incisor abutments (group B), leucite ceramic crowns bonded on incisor abutments (group C), premolar abutments directly veneered with a fluor apatite ceramic (group D (layered) and group E (pressed)) and premolar abutments bonded with lithium disilicate ceramic crowns (group F). The fracture load of the restorations was evaluated using a universal testing machine. Half of each group was artificially aged (chewing simulation and thermocycling) before evaluating the fracture load with the exception of the test abutments. The fracture load of the test abutments was 705 ± 43N. Incisor abutments bonded with lithium disilicate or leucite ceramic crowns (groups B and C) showed fracture loads of about 580N. Premolar restorations directly veneered with fluor apatite ceramic (groups D and E) showed fracture loads of about 850N. Premolar restorations bonded with lithium disilicate ceramic crowns (group F) showed fracture loads of about 1850N. The artificial ageing showed no significant influence on the strength of the examined restorations. All ceramic crowns made of lithium disilicate glass-ceramic, adhesively bonded to premolar abutments showed the highest fracture loads in this study. However, all tested groups can withstand physiological bite forces. Copyright © 2010 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

Toward photostable multiplex analyte detection on a single mode planar optical waveguide

Energy Technology Data Exchange (ETDEWEB)

Mukundan, Harshini [Los Alamos National Laboratory; Xei, Hongshi [Los Alamos National Laboratory; Anderson, Aaron S [Los Alamos National Laboratory; Grace, Wynne K [Los Alamos National Laboratory; Martinez, Jennifer S [NON LANL; Swanson, Basil [Los Alamos National Laboratory

2009-01-01

We have developed a waveguide-based optical biosensor for the sensitive and specific detection of biomarkers associated with disease. Our technology combines the superior optical properties of single-mode planar waveguides, the robust nature of functionalized self-assembled monolayer sensing films and the specificity of fluorescence sandwich immunoassays to detect biomarkers in complex biological samples such as serum, urine and sputum. We have previously reported the adaptation of our technology to the detection of biomarkers associated with breast cancer and anthrax. However, these approaches primarily used phospholipid bilayers as the functional film and organic dyes (ex: AlexaFluors) as the fluorescence reporter. Organic dyes are easily photodegraded and are not amenable to multiplexing because of their narrow Stokes' shift. Here we have developed strategies for conjugation of the detector antibodies with quantum dots for use in a multiplex detection platform. We have previously evaluated dihydroxylipoic acid quantum dots for the detection of a breast cancer biomarker. In this manuscript, we investigate the detection of the Bacillus anthracis protective antigen using antibodies conjugated with polymer-coated quantum dots. Kinetics of binding on the waveguide-based biosensor is reported. We compare the sensitivity of quantum dot labeled antibodies to those labeled with AlexaFluor and demonstrate the photostability of the former in our assay platform. In addition, we compare sulfydryl labeling of the antibody in the hinge region to that of nonspecific amine labeling. This is but the first step in developing a multiplex assay for such biomarkers on our waveguide platform.

A fluorescence resonance energy transfer-based approach for investigating late endosome–lysosome retrograde fusion events

Science.gov (United States)

Kaufmann, A.M.; Goldman, S.D.B.; Krise, J.P.

2009-01-01

Traditionally, lysosomes have been considered to be a terminal endocytic compartment. Recent studies suggest that lysosomes are quite dynamic, being able to fuse with other late endocytic compartments as well as with the plasma membrane. Here we describe a quantitative fluorescence energy transfer (FRET)-based method for assessing rates of retrograde fusion between terminal lysosomes and late endosomes in living cells. Late endosomes were specifically labeled with 800-nm latex beads that were conjugated with streptavidin and Alexa Fluor 555 (FRET donor). Terminal lysosomes were specifically labeled with 10,000-MW dextran polymers conjugated with biotin and Alexa Fluor 647 (FRET acceptor). Following late endosome–lysosome fusion, the strong binding affinity between streptavidin and biotin brought the donor and acceptor fluorophore molecules into close proximity, thereby facilitating the appearance of a FRET emission signal. Because apparent size restrictions in the endocytic pathway do not permit endocytosed latex beads from reaching terminal lysosomes in an anterograde fashion, the appearance of the FRET signal is consistent with retrograde transport of lysosomal cargo back to late endosomes. We assessed the efficiency of this transport step in fibroblasts affected by different lysosome storage disorders—Niemann–Pick type C, mucolipidosis type IV, and Sandhoff’s disease, all of which have a similar lysosomal lipid accumulation phenotype. We report here, for the first time, that these disorders can be distinguished by their rate of transfer of lysosome cargos to late endosomes, and we discuss the implications of these findings for developing new therapeutic strategies. PMID:19109922

Modelling a Global EPCM (Engineering, Procurement and Construction Management Enterprise

Directory of Open Access Journals (Sweden)

Sekhar Chattopadhyay

2010-03-01

Full Text Available This paper investigates the applicability of enterprise architectures in the context of current business environment by examining the application of Purdue Enterprise Reference Architecture to WorleyParsons, a global engineering, procurement and construction management enterprise, under the backdrop of a similar study carried out on Fluor Daniel during mid-nineties of the last century. The outcome of this study recommends the need for new enterprise architecture, the People-Centric Enterprise Architecture that not only focuses on human dimension in modern enterprises as the central thread, but also includes more business characteristics of the enterprise other than engineerings.

Fluorine toxicity in corn plants nearby a ceramic industry, Araras, State of São Paulo, Brazil

OpenAIRE

Fortes, Caio; Duarte, Aildson Pereira; Matsuoka, Sizuo; Hoffman, Hermann P.; Lavorenti, Norberto Antônio

2003-01-01

Indústrias que submetem material terroso a altas temperaturas como a de cerâmicas, emitem fluoretos para a atmosfera na forma de gás, particulado ou ácido fluorídrico. Em experimentos de milho (Zea mays L.), do Centro de Ciências Agrárias da Universidade Federal de São Carlos, Araras (SP), as plantas apresentaram sintomas que evoluíam de uma descoloração do limbo foliar até o secamento marginal das folhas. O objetivo deste trabalho foi avaliar os teores foliares de flúor (F) na cultura do mil...

Triton X-100 as a complete liquid scintillation cocktail for counting aqueous solutions and ionic nutrient salts

International Nuclear Information System (INIS)

Reed, D.W.

1984-01-01

Triton X-100, used alone, was found to act as a complete liquid scintillation cocktail. Triton X-100 acted as a scintillator and the effect was not due to Cerenkov radiation. A variety of other commercially available surfactants also acted as scintillators, but with different levels of efficiency. Triton X-100/water combinations were suitable for counting aqueous solutions of 33 P and 86 Rb and the count rate was stable over extended periods of time. Triton X-100/toluene combinations also yielded high counting efficiencies. Triton X-100 was more sensitive to quenching than standard cocktails containing fluors. (author)

NHC's contribution to cleanup of the Hanford Site

International Nuclear Information System (INIS)

Chauve, H.D.

1998-01-01

The one billion dollars per year Project Hanford Management Contract (PHMC), managed by Fluor Daniel Hanford, calls for cleanup of the Hanford Site for the Department of Energy. Project Hanford comprises four major subprojects, each managed by a different major contractor. Numatec Hanford Corporation (NHC) is a fifth major subcontractor which provides energy and technology to each of the Hanford projects. NHC draws on the experience and capabilities of its parent companies, COGEMA and SGN, and relies on local support from its sister Company in Richland, COGEMA Engineering Corporation, to bring the best commercial practices and new technology to the Project

Cu2+-labeled dansyl compounds as fluorescent and PET probes for imaging apoptosis.

Science.gov (United States)

Han, Junyan; Wang, Xukui; Yu, MeiXiang

2016-11-15

Compound DNSTT-Cu 2+ , a novel chelate of Cu 2+ with DOTA conjugated to a fluorescent dansyl fragment, is developed for imaging cell apoptosis. Apoptotic U-87MG cells could be selectively visualized by the fluorescence of DNSTT-Cu 2+ from cytoplasm of cells, confirmed by the fluorescence of apoptosis cells co-labeled with Alexa Fluor 568-labeled annexin V, a conventional probe for selectively labeling membranes of apoptosis cells. A radioactive 64 Cu 2 + analog, DNSTT- 64 Cu 2+ , was easily synthesized, providing a potential PET probe for imaging apoptosis in vivo. Copyright © 2016 Elsevier Ltd. All rights reserved.

Obtenção e caracterização de membranas assimétricas via sol-gel

OpenAIRE

Lenza,R. F. S.; Costa,R. O. R.; Vasconcelos,W. L.

2002-01-01

Foram obtidas membranas de sílica via sol-gel, utilizando-se tetraetilortossilicato (TEOS) como precursor em meio ácido. A estrutura da membrana é composta de uma camada de sílica mesoporosa (raio médio de poros igual a 21,6 nm) recoberta por um filme microporoso de sílica (raio médio de poros igual a 1,1 nm). A camada suporte foi obtida utilizando-se ácido fluorídrico como catalisador, enquanto que para a fabricação do filme ativo foi utilizado ácido nítrico. A camada suporte apresenta área ...

El efecto del entorno en la emisión de fluorescencia . Modelos teóricos y aplicaciones analíticas

OpenAIRE

Delgado Camón, Mª Arantzazu

2012-01-01

En esta Tesis Doctoral se abordan aspectos teóricos y prácticos de la fluorescencia molecular, en medio líquido y sólido, que pueden resumirse en: 1.- Estudio y utilización del efecto del entorno molecular en la intensidad de fluorescencia, que se refiere a cómo las interacciones no covalentes que sufre un fluoróforo en presencia de un analito y un disolvente afectan a su emisión y a la utilización de esos cambios para obtener información analítica del entorno. Para ello se ha desarrollad...

Estudio del grado de madurez y/o maduración de tomates empleando técnicas espectroscópicas moleculares

OpenAIRE

Jurado Capel, Laura

2012-01-01

Este Trabajo Fin de Máster versa sobre el estudio de la madurez en tomates evaluando la evolución de distintos pigmentos (carotenos, tocoferoles, flavonoides)y otros compuestos como el glutamato monosódico. Para ello se hace uso de técnicas espectroscópicas moleculares donde el análisis de la muestra se aborda a través de dos estrategias diferentes que permita comparar el análisis directo sobre la piel del fruto mediante ATR-FTIR y análisis de extractos metanólicos de la piel mediante Fluore...

Rapid separation and determination of 107Pd in radioactive waste produced during NPP A-1 decommissioning

International Nuclear Information System (INIS)

Boris Andris; Miroslav Prazsky; Ferdinand Sebesta

2015-01-01

Procedure for 107 Pd determination in radioactive wastes coming from decommissioning of NPP A-1 is proposed and verified. 107 Pd was separated and purified by Pd precipitation with dimethylglyoxime (DMG) and/or ferric hydroxide precipitation. 107 Pd yield was determined gravimetrically by weighing the Pd(DMG) 2 precipitate. 107 Pd counting was performed using liquid scintillation counter (LSC-TDCR) and scintillation cocktail Hionic Fluor. In all analyzed samples the determined activities of 107 Pd were lower than MDA. Nevertheless such analyses permit the decision concerning the storage of solidified wastes in the Mochovce regional repository. (author)

Solid Waste Integrated Forecast Technical (SWIFT) Report FY 2001 to FY 2046 Volume 1

International Nuclear Information System (INIS)

BARCOT, R.A.

2001-01-01

In an effort to maintain an up-to-date Solid Waste Forecast, Fluor Hanford, Inc. requested a midyear update to the FY2001 Solid Waste Forecast collected in June 2000. Below is a list of generators reporting significant changes from the baseline FY2001 forecast, as well as approved generators previously not reporting wastes. The updated data was collected in February 2001. The cumulative effect of the changes in the near term was minor. Included in this update are waste generation maps for onsite facilities. The maps are updated annually and use the baseline forecast as a data reference

Processing Th C{sub 2} - UC{sub 2} fuel extracted from high temperature reactors HTGCR; Etude du traitement des combustibles Th C{sub 2} - UC{sub 2} issus de reacteurs a haute temperature

Energy Technology Data Exchange (ETDEWEB)

Derrien, C; Lessart, P; Pianezza, E; Verry, C; Villain, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-07-01

The object of this investigation is solubilisation head-end (from crushing and grinding phase to non included first purification phase) of pulverulent ({sup 233}U/{sup 232}Th)C{sub 2} (200 - 500 microns diameter) contained in a graphite matrix extracted from a 4.10{sup 13} n.cm{sup -2}.s{sup -1} thermalized neutrons average flux with an irradiation of 80000 MWjT{sup -1} HTGCR reactor. After having succinctly described different bibliographic processes we have chosen the burn - leach of reactor fuel and graphite matrix containing it. The technology of burner is original in nuclear field and still more by utilizing ultra-sounds to intensify burning reaction and to minimize the weight of unburnables. The mixture of ThO{sub 2}, U{sub 3}O{sub 8}, and fission products oxides is solubilized by boiling HNO{sub 3} 13 M + HF 0.05 M. This process is profit-learning in a thorium recuperation and reprocessing point of view. In the contrary-case it would be interesting to consider a dry-process which would permit to separate solid ThF{sub 4} from gaseous UF{sub 6}. (authors) [French] Cette etude a pour objet le traitement initial de mise en solution ou 'head-end' (allant de la phase broyag-concassage a la phase de premiere purification exclue) d'un combustible ({sup 233}U/{sup 232}Th)C{sub 2} pulverulent (de 200 a 500 {mu} de diametre) contenu dans une matrice de graphite issu d'un reacteur HTGCR surgenerateur a neutrons thermiques de flux moyen 4. l0{sup 13} n.cm{sup -2}.s{sup -1} et taux d'irradiation 80000 MWjT{sup -1}. Apres exposition succincte des differents procedes bibliographiques decrits, nous avons finalement choisi le traitement par combustion-attaque ('Burn-Leach') du combustible et de la matrice etanche graphite qui le contient. La technologie du bruleur est originale dans le domaine nucleaire d'autant qu'elle utilise les ultra-sons pour ameliorer le rendement de la reaction de combustion et reduire au minimum le poids des imbrules. Le melange ThO{sub 2}, U{sub 3}O

ATR Spent Fuel Options Study

International Nuclear Information System (INIS)

Connolly, Michael James; Bean, Thomas E.; Brower, Jeffrey O.; Luke, Dale E.; Patterson, M. W.; Robb, Alan K.; Sindelar, Robert; Smith, Rebecca E.; Tonc, Vincent F.; Tripp, Julia L.; Winston, Philip L.

2017-01-01

The Advanced Test Reactor (ATR) is a materials and fuels test nuclear reactor that performs irradiation services for the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Naval Reactors, the National Nuclear Security Administration (NNSA), and other research programs. ATR achieved initial criticality in 1967 and is expected to operate in support of needed missions until the year 2050 or beyond. It is anticipated that ATR will generate approximately 105 spent nuclear fuel (SNF) elements per year through the year 2050. Idaho National Laboratory (INL) currently stores 2,008 ATR SNF elements in dry storage, 976 in wet storage, and expects to have 1,000 elements in wet storage before January 2017. A capability gap exists at INL for long-term (greater than the year 2050) management, in compliance with the Idaho Settlement Agreement (ISA), of ATR SNF until a monitored retrievable geological repository is open. INL has significant wet and dry storage capabilities that are owned by the DOE Office of Environmental Management (EM) and operated and managed by Fluor Idaho, which include the Idaho Nuclear Technology and Engineering Center's (INTEC's) CPP-666, CPP-749, and CPP-603. In addition, INL has other capabilities owned by DOE-NE and operated and managed by Battelle Energy Alliance, LLC (BEA), which are located at the Materials and Fuel Complex (MFC). Additional storage capabilities are located on the INL Site at the Naval Reactors Facility (NRF). Current INL SNF management planning, as defined in the Fluor Idaho contract, shows INTEC dry fuel storage, which is currently used for ATR SNF, will be nearly full after transfer of an additional 1,000 ATR SNF from wet storage. DOE-NE tasked BEA with identifying and analyzing options that have the potential to fulfill this capability gap. BEA assembled a team comprised of SNF management experts from Fluor Idaho, Savannah River Site (SRS), INL/BEA, and the MITRE Corp with an objective of developing and analyzing

ATR Spent Fuel Options Study

Energy Technology Data Exchange (ETDEWEB)

Connolly, Michael James [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bean, Thomas E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Brower, Jeffrey O. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Luke, Dale E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Patterson, M. W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Robb, Alan K. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sindelar, Robert [Idaho National Lab. (INL), Idaho Falls, ID (United States); Smith, Rebecca E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tonc, Vincent F. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tripp, Julia L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Winston, Philip L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2017-01-01

The Advanced Test Reactor (ATR) is a materials and fuels test nuclear reactor that performs irradiation services for the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Naval Reactors, the National Nuclear Security Administration (NNSA), and other research programs. ATR achieved initial criticality in 1967 and is expected to operate in support of needed missions until the year 2050 or beyond. It is anticipated that ATR will generate approximately 105 spent nuclear fuel (SNF) elements per year through the year 2050. Idaho National Laboratory (INL) currently stores 2,008 ATR SNF elements in dry storage, 976 in wet storage, and expects to have 1,000 elements in wet storage before January 2017. A capability gap exists at INL for long-term (greater than the year 2050) management, in compliance with the Idaho Settlement Agreement (ISA), of ATR SNF until a monitored retrievable geological repository is open. INL has significant wet and dry storage capabilities that are owned by the DOE Office of Environmental Management (EM) and operated and managed by Fluor Idaho, which include the Idaho Nuclear Technology and Engineering Center’s (INTEC’s) CPP-666, CPP-749, and CPP-603. In addition, INL has other capabilities owned by DOE-NE and operated and managed by Battelle Energy Alliance, LLC (BEA), which are located at the Materials and Fuel Complex (MFC). Additional storage capabilities are located on the INL Site at the Naval Reactors Facility (NRF). Current INL SNF management planning, as defined in the Fluor Idaho contract, shows INTEC dry fuel storage, which is currently used for ATR SNF, will be nearly full after transfer of an additional 1,000 ATR SNF from wet storage. DOE-NE tasked BEA with identifying and analyzing options that have the potential to fulfill this capability gap. BEA assembled a team comprised of SNF management experts from Fluor Idaho, Savannah River Site (SRS), INL/BEA, and the MITRE Corp with an objective of developing and analyzing

The influences of sensitivity of ligand in determination of fluors with LaF3

International Nuclear Information System (INIS)

Muzakky; Lahagu, F.; Djawahiri, H.M.; Susiaturi, E.

1996-01-01

The influences of acetate and carbonate ligand as a binder of uranium in uranium-tetra fluoride solution, with 0,1 M HNO 3 acid condition was been studied. The aim of binding is to looses of uranium from UO 2 (F 4 ) 2- compound, so the free of fluoride were able detected with LaF 3 membrane electrode on potentiometric method. Base on the free of Fluoride, acetate ligand was more sensitive than carbonate ligand. The addition method was able to prevented influent of HF species in high acidity was realized. The method was use to determination of Fluoride in C oncentrated Uranium , and yield are 1,215x10 -5 M±1,957x10 -4 in acetate ligand and 3,957x10 -5 M±2,57x10 -4 in carbonate ligand. (author)

PENGARUH SUMBER MINERAL TERHADAP PENEKANAN Erwinia carotovora OLEH PSEUDOMONAS PENDAR-FLUOR SECARA IN VITRO

Directory of Open Access Journals (Sweden)

Hardian Susilo Addy .

2012-02-01

Full Text Available Antimicrobial Stimulation of Fluorescent Pseudomonad to Inhibit Soft-rot Pathogen Caused by Erwinia carotovora subsp. Carotovora. This research was conducted to study effect of mineral sources on inhibition Erwinia carotovora by fluorescent pseudomonad. We used several mineral sources to stimulate antimicrobial substances from fluorescent pseudomonad that responsible to inhibit E. carotovora subsp. carotovora in vitro. The results showed that zinc 0,5 mM were the best to increase antagonistics of fluorescent psudomonad againts E. carotovora. Zinc were increased antimicrobial substances twohold compared with control without stimulant agent. Detection of antimicrobial substance using TLC showed that only one antimicrobial was detected with retention factor (Rf of 0,68 – 0,72. However, identification and characterization of that substance is still needed.

Hydrothermal Testing of K Basin Sludge and N Reactor Fuel at Sludge Treatment Project Operating Conditions

Energy Technology Data Exchange (ETDEWEB)

Delegard, Calvin H.; Schmidt, Andrew J.; Thornton, Brenda M.

2007-03-30

The Sludge Treatment Project (STP), managed for the U. S. DOE by Fluor Hanford (FH), was created to design and operate a process to eliminate uranium metal from K Basin sludge prior to packaging for Waste Isolation Pilot Plant (WIPP). The STP process uses high temperature liquid water to accelerate the reaction, produce uranium dioxide from the uranium metal, and safely discharge the hydrogen. Under nominal process conditions, the sludge will be heated in pressurized water at 185°C for as long as 72 hours to assure the complete reaction (corrosion) of up to 0.25-inch diameter uranium metal pieces. Under contract to FH, the Pacific Northwest National Laboratory (PNNL) conducted bench-scale testing of the STP hydrothermal process in November and December 2006. Five tests (~50 ml each) were conducted in sealed, un-agitated reaction vessels under the hydrothermal conditions (e.g., 7 to 72 h at 185°C) of the STP corrosion process using radioactive sludge samples collected from the K East Basin and particles/coupons of N Reactor fuel also taken from the K Basins. The tests were designed to evaluate and understand the chemical changes that may be occurring and the effects that any changes would have on sludge rheological properties. The tests were not designed to evaluate engineering aspects of the process. The hydrothermal treatment affected the chemical and physical properties of the sludge. In each test, significant uranium compound phase changes were identified, resulting from dehydration and chemical reduction reactions. Physical properties of the sludge were significantly altered from their initial, as-settled sludge values, including, shear strength, settled density, weight percent water, and gas retention.

Distribution, structure and projections of the frog intracardiac neurons.

Science.gov (United States)

Batulevicius, Darius; Skripkiene, Gertruda; Batuleviciene, Vaida; Skripka, Valdas; Dabuzinskiene, Anita; Pauza, Dainius H

2012-05-21

Histochemistry for acetylcholinesterase was used to determine the distribution of intracardiac neurons in the frog Rana temporaria. Seventy-nine intracardiac neurons from 13 frogs were labelled iontophoretically by the intracellular markers Alexa Fluor 568 and Lucifer Yellow CH to determine their structure and projections. Total neuronal number per frog heart was (Mean ± SE) 1374 ± 56. Largest collections of neurons were found in the interatrial septum (46%), atrioventricular junction (25%) and venal sinus (12%). Among the intracellularly labelled neurons, we found the cells of unipolar (71%), multipolar (20%) and bipolar (9%) types. Multiple processes originated from the neuron soma, hillock and proximal axon. These processes projected onto adjacent neuron somata and cardiac muscle fibers within the interatrial septum. Average total length of the processes from proximal axon was 348 ± 50 μm. Average total length of processes from soma and hillock was less, 118 ± 27 μm and 109 ± 24 μm, respectively. The somata of 59% of neurons had bubble- or flake-shaped extensions. Most neurons from the major nerves in the interatrial septum sent their axons towards the ventricle. In contrast, most neurons from the ventral part of the interatrial septum sent their axons towards the atria. Our findings contradict to a view that the frog intracardiac ganglia contain only non-dendritic neurons of the unipolar type. We conclude that the frog intracardiac neurons are structurally complex and diverse. This diversity may account for the complicated integrative functions of the frog intrinsic cardiac ganglia. Copyright © 2012 Elsevier B.V. All rights reserved.

Noninvasive and Quantitative Assessment of In Vivo Fetomaternal Interface Angiogenesis Using RGD-Based Fluorescence

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M. Keramidas

2014-01-01

Full Text Available Angiogenesis is a key process for proper placental development and for the success of pregnancy. Although numerous in vitro methods have been developed for the assessment of this process, relatively few reliable in vivo methods are available to evaluate this activity throughout gestation. Here we report an in vivo technique that specifically measures placental neovascularization. The technique is based on the measurement of a fluorescent alpha v beta 3 (αvβ3 integrin-targeting molecule called Angiolone-Alexa-Fluor 700. The αvβ3 integrin is highly expressed by endothelial cells during the neovascularization and by trophoblast cells during their invasion of the maternal decidua. Angiolone was injected to gravid mice at 6.5 and 11.5 days post coitus (dpc. The fluorescence was analyzed one day later at 7.5 and 12.5 dpc, respectively. We demonstrated that (i Angiolone targets αvβ3 protein in the placenta with a strong specificity, (ii this technique is quantitative as the measurement was correlated to the increase of the placental size observed with increasing gestational age, and (iii information on the outcome is possible, as abnormal placentation could be detected early on during gestation. In conclusion, we report the validation of a new noninvasive and quantitative method to assess the placental angiogenic activity, in vivo.

Description of dental caries status of children aged 12 – 15 years in Berambai village, North Samarinda, East Kalimantan

Directory of Open Access Journals (Sweden)

Nurul Rahmadhani Nur

2016-06-01

Full Text Available Based on data RISKESDAS 2007 and 2013, national prevalence of oral and dental problems increased by 2.4% and national prevalence of active caries increased by 9.8%. National DMF-T index value is 4.6 in 2013. East Kalimantan has an active caries prevalence and DMF-T index value higher than the national average. Berambai village is one of the villages in the North Samarinda, East Kalimantan whose residents have problems with public water supply. The residents use ground water as their main source of clean water. The purpose of this study is to evaluate the caries status and fluoride content of drinking water consumed by Berambai children aged 12 – 15 years. This study is an observational study with cross sectional descriptive design, which is conducted in Berambai village, North Samarinda, East Kalimantan and Health Laboratory of East Kalimantan. The study was carried out in November 2015 involving children aged 12 – 15 years, born in that village until the study was performed. In addition, the fluoride content of drinking water was also evaluated. Each participant filled out the questionnaire and was then examinated his dental caries using DMF-T index. Data was analyzed by univariate analysis. The results showed that the average value of DMF-T was 3.92 (medium category, while the boys had DMF-T 4.63 (high category and the girls had DMF-T 3.14 (medium category. The fluor levels of drinking water is 0.00 ppm (low category. In conclusion, the caries status of children aged 12 – 15 years was in medium category and the fluor levels of drinking water was very low.

Influence of air pollution on cultivated plants

Energy Technology Data Exchange (ETDEWEB)

Spierings, F H.F.G.; Van Raay, A

1962-01-01

Fumigation experiments were carried out with tulips, gladioli and freesia to investigate the correlation between the extent of leaf injury caused by hydrogen fluoride, the fluor content of the damaged leaves and the fluor content of the air in the fumigation chambers. Fumigation experiments with SO/sub 2/ were carried out on several vegetables, e.g. endive, spinach, celery and tomato. On 28 experimental plots distributed throughout a horticultural area, the symptoms of HF damage were studied on freesia plants. At a distance of 6 km from the industrial area, 20% of the length of the leaves appeared to be damaged. 10 km from this area the percentage of damage was 15 and on the most distant plots an injury of 5% was still present. On more than 20 places in The Netherlands investigations have been carried out about injury of plants in the neighborhood of factories. In the vicinity of a cement-industry, an investigation has been started about the extent and the composition of dust from this industry deposited on vegetables and fruits. The monthly quantity of rain water was determined and the solid deposits in the rain were quantitatively and qualitatively investigated under the microscope. In the area near a hydrocyanic acid factory, damage was done to grass and to fruit trees. It was demonstrated by leaf analyses in both cases that the damage was caused by SO/sub 2/. Other cases of crop damage were imputed to poisoning of the air by sulfur dioxide or hydrogen fluoride, to acid containing soot deposits, to zinc oxide vapors and phenol containing vapors of resins.

Wide-field lifetime-based FRET imaging for the assessment of early functional distribution of transferrin-based delivery in breast tumor-bearing small animals

Science.gov (United States)

Sinsuebphon, Nattawut; Rudkouskaya, Alena; Barroso, Margarida; Intes, Xavier

2016-02-01

Targeted drug delivery is a critical aspect of successful cancer therapy. Assessment of dynamic distribution of the drug provides relative concentration and bioavailability at the target tissue. The most common approach of the assessment is intensity-based imaging, which only provides information about anatomical distribution. Observation of biomolecular interactions can be performed using Förster resonance energy transfer (FRET). Thus, FRET-based imaging can assess functional distribution and provide potential therapeutic outcomes. In this study, we used wide-field lifetime-based FRET imaging for the study of early functional distribution of transferrin delivery in breast cancer tumor models in small animals. Transferrin is a carrier for cancer drug delivery. Its interaction with its receptor is within a few nanometers, which is suitable for FRET. Alexa Fluor® 700 and Alexa Fluor® 750 were conjugated to holo-transferrin which were then administered via tail vein injection to the mice implanted with T47D breast cancer xenografts. Images were continuously acquired for 60 minutes post-injection. The results showed that transferrin was primarily distributed to the liver, the urinary bladder, and the tumor. The cellular uptake of transferrin, which was indicated by the level of FRET, was high in the liver but very low in the urinary bladder. The results also suggested that the fluorescence intensity and FRET signals were independent. The liver showed increasing intensity and increasing FRET during the observation period, while the urinary bladder showed increasing intensity but minimal FRET. Tumors gave varied results corresponding to their FRET progression. These results were relevant to the biomolecular events that occurred in the animals.

AN ADVANCED OXIDATION PROCESS : FENTON PROCESS

Directory of Open Access Journals (Sweden)

Engin GÜRTEKİN

2008-03-01

Full Text Available Biological wastewater treatment is not effective treatment method if raw wastewater contains toxic and refractory organics. Advanced oxidation processes are applied before or after biological treatment for the detoxification and reclamation of this kind of wastewaters. The advanced oxidation processes are based on the formation of powerful hydroxyl radicals. Among advanced oxidation processes Fenton process is one of the most promising methods. Because application of Fenton process is simple and cost effective and also reaction occurs in a short time period. Fenton process is applied for many different proposes. In this study, Fenton process was evaluated as an advanced oxidation process in wastewater treatment.

Hanford K basins spent nuclear fuel project update

International Nuclear Information System (INIS)

Williams, N.H.; Hudson, F.G.

1997-07-01

Twenty one hundred metric tons of spent nuclear fuel (SNF) are currently stored in the Hanford Site K Basins near the Columbia River. The deteriorating conditions of the fuel and the basins provide engineering and management challenges to assure safe current and future storage. DE and S Hanford, Inc., part of the Fluor Daniel Hanford, Inc. lead team on the Project Hanford Management Contract, is constructing facilities and systems to move the fuel from current pool storage to a dry interim storage facility away from the Columbia River, and to treat and dispose of K Basins sludge, debris and water. The process starts in K Basins where fuel elements will be removed from existing canisters, washed, and separated from sludge and scrap fuel pieces. Fuel elements will be placed in baskets and loaded into Multi-Canister Overpacks (MCOs) and into transportation casks. The MCO and cask will be transported to the Cold Vacuum Drying Facility, where free water within the MCO will be removed under vacuum at slightly elevated temperatures. The MCOs will be sealed and transported via the transport cask to the Canister Storage Building

Hanford spent nuclear fuel project update

Energy Technology Data Exchange (ETDEWEB)

Williams, N.H.

1997-08-19

Twenty one hundred metric tons of spent nuclear fuel (SNF) are currently stored in the Hanford Site K Basins near the Columbia River. The deteriorating conditions of the fuel and the basins provide engineering and management challenges to assure safe current and future storage. DE and S Hanford, Inc., part of the Fluor Daniel Hanford, Inc. lead team on the Project Hanford Management Contract, is constructing facilities and systems to move the fuel from current pool storage to a dry interim storage facility away from the Columbia River, and to treat and dispose of K Basins sludge, debris and water. The process starts in K Basins where fuel elements will be removed from existing canisters, washed, and separated from sludge and scrap fuel pieces. Fuel elements will be placed in baskets and loaded into Multi-Canister Overpacks (MCOs) and into transportation casks. The MCO and cask will be transported to the Cold Vacuum Drying Facility, where free water within the MCO will be removed under vacuum at slightly elevated temperatures. The MCOs will be sealed and transported via the transport cask to the Canister Storage Building.

CY2003 RCRA GROUNDWATER MONITORING WELL SUMMARY REPORT

International Nuclear Information System (INIS)

MARTINEZ, C.R.

2003-01-01

This report describes the calendar year (CY) 2003 field activities associated with the installation of two new groundwater monitoring wells in the A-AX Waste Management Area (WMA) and four groundwater monitoring wells in WMA C in the 200 East Area of the Hanford Nuclear Reservation. All six wells were installed by Fluor Hanford Inc. (FH) for CH2M Hill Hanford Group, Inc. (CHG) in support of Draft Hanford Facility Agreement and Consent Order (Tri-Party Agreement) M-24-00 milestones and ''Resource Conservation and Recovery Act of 1976'' (RCRA) groundwater monitoring requirements. Drilling data for the six wells are summarized in Table 1

Influencia del CaF2 sobre la capacidad de reacción de crudos de cemento

OpenAIRE

Palomo, Ángel; Blanco, M. Teresa

1982-01-01

En este trabajo se estudia el efecto de una pequeña cantidad de CaF2 sobre la capacidad de reacción de crudos de cemento, para lo cual se comparan los comportamientos térmicos en función del tiempo de clinkerización de un crudo comercial con y sin adición de CaF2. Se da una estimación de los tiempos necesarios para completar las reacciones a diferentes temperaturas. El efecto mineralizador del espato-fluor pasa por un máximo a temperaturas de clinkerización del orden de 1.200ºC y tiempos d...

Training Workers to use Localized Ventilation for Radiological Work

International Nuclear Information System (INIS)

WAGGONER, L.O.

2000-01-01

Work on radiological systems and components needs to be accomplished using techniques that reduce radiation dose to workers, limit contamination spread, and minimize radioactive waste. One of the best methods to control contamination spread is to use localized ventilation to capture radioactive material and keep it from spreading. The Fluor Hanford ALARA Center teaches workers how to use ventilation in partnership with other engineered controls and this has resulted in improved work practices, minimized the impact on adjacent work operations, and decreased the amount of radioactive waste generated. This presentation will emphasize how the workers are trained to use localized ventilation for contamination control

Radiation damage in plastic scintillators

International Nuclear Information System (INIS)

Majewski, S.

1990-01-01

Results of radiation damage studies in plastic scintillators are reviewed and critically analyzed from the point of view of applications of plastic scintillators in calorimetric detectors for the SSC. Damage to transmission and to fluorescent yield in different conditions is discussed. New directions in R ampersand D are outlined. Several examples are given of the most recent data on the new scintillating materials made with old and new plastics and fluors, which are exhibiting significantly improved radiation resistance. With a present rate of a vigorous R D programme, the survival limits in the vicinity of 100 MRad seem to be feasible within a couple of years

La fluoración de aguas en la región de Murcia

OpenAIRE

Marín Camaches Maria Dolores; Pacheco Martínez Francisco; Martínez Gambín Remedios; Gomez Campoy Elisa; Gutierrez Molina Carolina

1998-01-01

FUNDAMENTO: El objeto de este trabajo es exponer las concentraciones naturales del ión fluor en las aguas de abastecimiento público de todos los municipios de la Región de Murcia en el año 1991, así como la evolución de dichas concentraciones en el periodo 1992-96 en el que se ha producido una fluoración en el suministro de agua como medida sanitaria pública. MÉTODOS: Los métodos utilizados para las determinaciones han sido el de la valoración potenciométrica mediante adición estándar y el de...

24 Command Fire Improvement Action Program Plan

International Nuclear Information System (INIS)

GRIFFIN, G.B.

2000-01-01

Fluor Hanford (FH) is responsible for providing support to the Department of Energy Richland Operations Office (RL) in the implementation of the Hanford Emergency Preparedness (EP) program. During fiscal year 2000, a number of program improvements were identified from various sources including a major range fire (24 Command Fire). Evaluations of the emergency preparedness program have confirmed that it currently meets all requirements and that performance of personnel involved is good, however the desire to effect continuous improvement resulted in the development of this improvement program plan. This program plan defines the activities that will be performed in order to achieve the desired performance improvements

Performance of 2000CA/LL and 2260XL liquid scintillation spectrometers for low-level tritium and carbon-14 analyses

International Nuclear Information System (INIS)

Rozanski, K.; Stichler, W.; Schwarz, P.

1991-01-01

The performance of two commercially available liquid scintillation spectrometers for low-level counting of 3 H and 14 C has been investigated. Two models of new technology Tri-Carb spectrometers from the Packard Instrument Company were tested: the 2000CA/LL and 2260XL. The measurements revealed a superior 3 H performance of the 2000CA/LL equipment owing to its substantially higher counting efficiency. Results for 14 C are less conclusive and depend on the configuration of the counting parameters selected. A comparison of three commercially available scintillation cocktails for tritium assay in water samples revealed a superior performance for PicoFluor LLT. (Author)

PMT signal increase using a wavelength shifting paint

Energy Technology Data Exchange (ETDEWEB)

Allada, K. [Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Hurlbut, Ch. [Eljen Technology, Sweetwater, TX 79556 (United States); Ou, L.; Schmookler, B. [Massachusetts Institute of Technology, Cambridge, MA 02139 (United States); Shahinyan, A. [Yerevan Physics Institute, Yerevan (Armenia); Wojtsekhowski, B., E-mail: bogdanw@jlab.org [Thomas Jefferson National Accelerator Facility, Newport News, VA 23606 (United States)

2015-05-11

We report a 1.65 times increase of the PMT signal and a simple procedure of application of a new wavelength shifting (WLS) paint for PMTs with non-UV-transparent windows. Samples of four different WLS paints, made from hydrocarbon polymers and organic fluors, were tested on a 5-in. PMT (ET 9390KB) using Cherenkov radiation produced in fused silica disks by {sup 106}Ru electrons on a ‘table-top’ setup. The best performing paint was employed on two different types of 5-in. PMTs (ET 9390KB and XP4572B), installed in atmospheric pressure CO{sub 2} gas Cherenkov detectors, and tested using GeV electrons.

¿Agua de consumo humano con o sin flúor?

Directory of Open Access Journals (Sweden)

Jaime-Gonzáles-Murillo

2013-01-01

Full Text Available Los beneficios de la utilización de Flúor en la salud dental han sido convencionalmente aceptados, sinembargo en la actualidad nuevas investigaciones en salud humana revelan la urgencia por evitar la ingestión de Fluor al punto de inclusive modificar programas de salud e implementar nuevas investigaciones. Los gobiernos como Canadá, Estados Unidos Chile, Países Europeos y Asiáticos que han invertido cifras millonarias en Fluorización pública; ahora deben modificar sus programas e investigar daños causados. Por este motivo la dotación de agua deberá seguir estas directrices.

Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles.

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Arnaud Beduneau

Full Text Available BACKGROUND: We posit that the same mononuclear phagocytes (MP that serve as target cells and vehicles for a host of microbial infections can be used to improve diagnostics and drug delivery. We also theorize that physical and biological processes such as particle shape, size, coating and opsonization that affect MP clearance of debris and microbes can be harnessed to facilitate uptake of nanoparticles (NP and tissue delivery. METHODS: Monocytes and monocyte-derived macrophages (MDM were used as vehicles of superparamagnetic iron oxide (SPIO NP and immunoglobulin (IgG or albumin coated SPIO for studies of uptake and distribution. IgG coated SPIO was synthesized by covalent linkage and uptake into monocytes and MDM investigated related to size, time, temperature, concentration, and coatings. SPIO and IgG SPIO were infused intravenously into naïve mice. T(2 measures using magnetic resonance imaging (MRI were used to monitor tissue distribution in animals. RESULTS: Oxidation of dextran on the SPIO surface generated reactive aldehyde groups and permitted covalent linkage to amino groups of murine and human IgG and F(ab'(2 fragments and for Alexa Fluor(R 488 hydroxylamine to form a Schiff base. This labile intermediate was immediately reduced with sodium cyanoborohydride in order to stabilize the NP conjugate. Optical density measurements of the oxidized IgG, F(ab'(2, and/or Alexa Fluor(R 488 SPIO demonstrated approximately 50% coupling yield. IgG-SPIO was found stable at 4 degrees C for a period of 1 month during which size and polydispersity index varied little from 175 nm and 200 nm, respectively. In vitro, NP accumulated readily within monocyte and MDM cytoplasm after IgG-SPIO exposure; whereas, the uptake of native SPIO in monocytes and MDM was 10-fold less. No changes in cell viability were noted for the SPIO-containing monocytes and MDM. Cell morphology was not changed as observed by transmission electron microscopy. Compared to unconjugated

The Fernald Closure Project: Lessons Learned

International Nuclear Information System (INIS)

Murphy, Cornelius M.; Carr, Dennis

2008-01-01

For nearly 37 years, the U.S. Department of Energy site at Fernald - near Cincinnati, Ohio - produced 230,000 metric tons (250,000 short tons) of high-purity, low-enriched uranium for the U.S. Defense Program, generating more than 5.4 million metric tons (6 million short tons) of liquid and solid waste as it carried out its Cold War mission. The facility was shut down in 1989 and clean up began in 1992, when Fluor won the contract to clean up the site. Cleaning up Fernald and returning it to the people of Ohio was a $4.4 billion mega environmental-remediation project that was completed in October 2006. Project evolved through four phases: - Conducting remedial-investigation studies to determine the extent of damage to the environment and groundwater at, and adjacent to, the production facilities; - Selecting cleanup criteria - final end states that had to be met that protect human health and the environment; - Selecting and implementing the remedial actions to meet the cleanup goals; - Executing the work in a safe, compliant and cost-effective manner. In the early stages of the project, there were strained relationships - in fact total distrust - between the local community and the DOE as a result of aquifer contamination and potential health effects to the workers and local residents. To engage citizens and interested stakeholders groups in the decision-making process, the DOE and Fluor developed a public-participation strategy to open the channels of communication with the various parties: site leadership, technical staff and regulators. This approach proved invaluable to the success of the project, which has become a model for future environmental remediation projects. This paper will summarize the history and shares lessons learned: the completion of the uranium-production mission to the implementation of the Records of Decision defining the cleanup standards and the remedies achieved. Lessons learned fall into ten categories: - Regulatory approach with end

Control system for technological processes in tritium processing plants with process analysis

International Nuclear Information System (INIS)

Retevoi, Carmen Maria; Stefan, Iuliana; Balteanu, Ovidiu; Stefan, Liviu; Bucur, Ciprian

2005-01-01

Integration of a large variety of installations and equipment into a unitary system for controlling the technological process in tritium processing nuclear facilities appears to be a rather complex approach particularly when experimental or new technologies are developed. Ensuring a high degree of versatility allowing easy modifications in configurations and process parameters is a major requirement imposed on experimental installations. The large amount of data which must be processed, stored and easily accessed for subsequent analyses imposes development of a large information network based on a highly integrated system containing the acquisition, control and technological process analysis data as well as data base system. On such a basis integrated systems of computation and control able to conduct the technological process could be developed as well protection systems for cases of failures or break down. The integrated system responds to the control and security requirements in case of emergency and of the technological processes specific to the industry that processes radioactive or toxic substances with severe consequences in case of technological failure as in the case of tritium processing nuclear plant. In order to lower the risk technological failure of these processes an integrated software, data base and process analysis system are developed, which, based on identification algorithm of the important parameters for protection and security systems, will display the process evolution trend. The system was checked on a existing plant that includes a removal tritium unit, finally used in a nuclear power plant, by simulating the failure events as well as the process. The system will also include a complete data base monitoring all the parameters and a process analysis software for the main modules of the tritium processing plant, namely, isotope separation, catalytic purification and cryogenic distillation

Plutonium Finishing Plant (PFP) Final Safety Analysis Report (FSAR) [SEC 1 THRU 11

Energy Technology Data Exchange (ETDEWEB)

ULLAH, M K

2001-02-26

The Plutonium Finishing Plant (PFP) is located on the US Department of Energy (DOE) Hanford Site in south central Washington State. The DOE Richland Operations (DOE-RL) Project Hanford Management Contract (PHMC) is with Fluor Hanford Inc. (FH). Westinghouse Safety Management Systems (WSMS) provides management support to the PFP facility. Since 1991, the mission of the PFP has changed from plutonium material processing to preparation for decontamination and decommissioning (D and D). The PFP is in transition between its previous mission and the proposed D and D mission. The objective of the transition is to place the facility into a stable state for long-term storage of plutonium materials before final disposition of the facility. Accordingly, this update of the Final Safety Analysis Report (FSAR) reflects the current status of the buildings, equipment, and operations during this transition. The primary product of the PFP was plutonium metal in the form of 2.2-kg, cylindrical ingots called buttoms. Plutonium nitrate was one of several chemical compounds containing plutonium that were produced as an intermediate processing product. Plutonium recovery was performed at the Plutonium Reclamation Facility (PRF) and plutonium conversion (from a nitrate form to a metal form) was performed at the Remote Mechanical C (RMC) Line as the primary processes. Plutonium oxide was also produced at the Remote Mechanical A (RMA) Line. Plutonium processed at the PFP contained both weapons-grade and fuels-grade plutonium materials. The capability existed to process both weapons-grade and fuels-grade material through the PRF and only weapons-grade material through the RMC Line although fuels-grade material was processed through the line before 1984. Amounts of these materials exist in storage throughout the facility in various residual forms left from previous years of operations.

Markov Processes in Image Processing

Science.gov (United States)

Petrov, E. P.; Kharina, N. L.

2018-05-01

Digital images are used as an information carrier in different sciences and technologies. The aspiration to increase the number of bits in the image pixels for the purpose of obtaining more information is observed. In the paper, some methods of compression and contour detection on the basis of two-dimensional Markov chain are offered. Increasing the number of bits on the image pixels will allow one to allocate fine object details more precisely, but it significantly complicates image processing. The methods of image processing do not concede by the efficiency to well-known analogues, but surpass them in processing speed. An image is separated into binary images, and processing is carried out in parallel with each without an increase in speed, when increasing the number of bits on the image pixels. One more advantage of methods is the low consumption of energy resources. Only logical procedures are used and there are no computing operations. The methods can be useful in processing images of any class and assignment in processing systems with a limited time and energy resources.

77 FR 23269 - Determination That FUNDUSCEIN-25 (fluorescein sodium injection), 25%, and AK-FLUOR (fluorescein...

Science.gov (United States)

2012-04-18

... marketing for reasons other than safety or effectiveness. ANDAs that refer to FUNDUSCEIN-25 (fluorescein...), 25%, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness AGENCY: Food and Drug... withdrawn from sale for reasons of safety or effectiveness. This determination will allow FDA to approve...

Data on the water balance in plants in the presence of fluor in the substrate

Energy Technology Data Exchange (ETDEWEB)

Navara, J

1969-01-01

Experiments were performed to determine the water balance of Pisum sativm to fluorine compounds. The results indicate that fluorine compounds in the substrate caused a withering of the above soil portions of the plants due to a disruption in the water balance. Water intake was generally observed to be reduced along with an increase in F concentration.

RETENSI DAN INTRUNSI FLUOR PADA PERMUKAAN EMAIL SETELAH APLIKASI DENGAN SUBSTRAT IKAN TERI (Stolephorus sp.

Directory of Open Access Journals (Sweden)

Harun Asyiq Gunawan

2015-08-01

Full Text Available Background: Topical fluoridation recently is still the main caries prevention method. Fluoride application on enamel surface is aimed to convert the hydroxyapatite (HA crystal to fluoroapatite (FA or hydroxyfluoroapatite (HFA form. Fluoride retention and intrusion onto enamel after fluoride application, therefore, are the most important factors to ensure the formation of FA and HFA crystals. Natural fluoride sources can be obtained from sea fishes, like teri (anchovy fish. Teri medan (S baganesis and teri jengki (S insularis are the most popular teri fishes in Indonesia, and they are known to have high fluoride content, 17-34 ppm. This research objectives are to measure fluoride retention and intrusion on enamel surface after application using teri medan and teri jengki substrate. Material and Method : 8 extracted third impacted molars were used. During the research, those teeth are immersed in ono-ionic aquadest (aquadem. Each tooth were cut bucco-lingually and mesio-distally, to obtain 4 enamel specimens. The specimens (totally 32 the divided into 3 major groups. 12 each for EDS group, and intrusion groups, and 8 for control. The EDS group divided into 2 sub-groups for application with teri medan and teri jengki. Similar procedure were done for intrusion and control groups. All EDS and intrusion specimens, then, immersed in the 5% teri substrate for 5 minutes, flushed with aquadem, then stored in aquadem for 3 hours. Procedure above then repeated 26 times. Control specimens were immersed in saline for 5 minutes, before flush and stored in the aquadem solution. All the EDS specimens, examinated using LEø Scanning and micro analysis electron microscope. Intrusion groups evaluated with Olypus BX41TF fluorescence microscope. Results : Fluoride retention for teri jengki groups is 5,28% and for teri medan group is 3,26%, while for control group is 1,94%. Fluoride intrusion for teri jengki group is 11,48 µm, teri medan 8,74 µm, and for control group is 0,84 µm. Anova and Bonferroni test, showed different result between experiment and control group, and between teri jengki and teri medan group, both for retention and intrusion examinations. Conclusion : Based in this research, it can be concluded that teri jengki and teri medan fishes substrate, give better result on fluoride retention and intrusion on enamel surface, compared to the control group. Application using teri jengki substrate gives better fluoride retention and intrusion on enamel surface compare to the teri medan substrate application.

Study on Regional Geology and Uranium Mineralization of Schwaner Mountains West and Central Kalimantan

International Nuclear Information System (INIS)

Soepradto-Tjokrokardono; Djoko-Soetarno; MS; Liliek-Subiantoro; Retno-Witjahyati

2004-01-01

Uranium occurrences indication in Kalimantan has been discovered at metamorphic and granites rocks of Schwaner Mountains as the radioactivity and geochemical anomalies. A regional geology of Schwaner Mountains show a watershed of West and East Kalimantan consist of Pinoh metamorphic rocks that was intruded by tonalitic and granitic batholite. The goal of this study is to observe the mechanism of the Uranium occurrences related to the regional tectonic, metamorphic rocks, tonalite and granitic batholite. Permokarbonaferrous metamorphic rocks as the big masses of roof pendant within tonalite mass. The metamorphic rocks originally as the big masses of roof pendant within tonalite mass. The metamorphic rocks originally derived from sedimentary process that produce a high content of uranium as well as a fine grained volcanic material. This uranium is deposited within neritic facies. Those sediments have been metamorphosed by low grade Abukuma regional metamorphism at the condition about 540 o C and 2000 bar. In early Cretaceous Tonalite of Sep auk intruded the rock and both metamorphics and tonalites. Those rocks were intruded by Late Cretaceous alkalin granite of Sukadana. Those crystalline rocks overlaid by an unconformity-related Kampari and Tebidah Formations that including within Melawi Group of Tertiary age. Uranium mineralization as the centimetric-metric veins related to tectonic N 100 o -110 o E and N 50 o E lineaments. Uranium was interpreted as a volcanic sedimentary origin, than it re mobilized by low grade regional metamorphism process. This enuchment process was carried out by fluor, boron and other metalliferous mineral within hydrothermal solutions of Sukadana granite. (author)

Thinning spatial point processes into Poisson processes

DEFF Research Database (Denmark)

Møller, Jesper; Schoenberg, Frederic Paik

, and where one simulates backwards and forwards in order to obtain the thinned process. In the case of a Cox process, a simple independent thinning technique is proposed. In both cases, the thinning results in a Poisson process if and only if the true Papangelou conditional intensity is used, and thus can......This paper describes methods for randomly thinning certain classes of spatial point processes. In the case of a Markov point process, the proposed method involves a dependent thinning of a spatial birth-and-death process, where clans of ancestors associated with the original points are identified...... be used as a diagnostic for assessing the goodness-of-fit of a spatial point process model. Several examples, including clustered and inhibitive point processes, are considered....

Process validation for radiation processing

International Nuclear Information System (INIS)

Miller, A.

1999-01-01

Process validation concerns the establishment of the irradiation conditions that will lead to the desired changes of the irradiated product. Process validation therefore establishes the link between absorbed dose and the characteristics of the product, such as degree of crosslinking in a polyethylene tube, prolongation of shelf life of a food product, or degree of sterility of the medical device. Detailed international standards are written for the documentation of radiation sterilization, such as EN 552 and ISO 11137, and the steps of process validation that are described in these standards are discussed in this paper. They include material testing for the documentation of the correct functioning of the product, microbiological testing for selection of the minimum required dose and dose mapping for documentation of attainment of the required dose in all parts of the product. The process validation must be maintained by reviews and repeated measurements as necessary. This paper presents recommendations and guidance for the execution of these components of process validation. (author)

Thinning spatial point processes into Poisson processes

DEFF Research Database (Denmark)

Møller, Jesper; Schoenberg, Frederic Paik

2010-01-01

are identified, and where we simulate backwards and forwards in order to obtain the thinned process. In the case of a Cox process, a simple independent thinning technique is proposed. In both cases, the thinning results in a Poisson process if and only if the true Papangelou conditional intensity is used, and......In this paper we describe methods for randomly thinning certain classes of spatial point processes. In the case of a Markov point process, the proposed method involves a dependent thinning of a spatial birth-and-death process, where clans of ancestors associated with the original points......, thus, can be used as a graphical exploratory tool for inspecting the goodness-of-fit of a spatial point process model. Several examples, including clustered and inhibitive point processes, are considered....

Process correlation analysis model for process improvement identification.

Science.gov (United States)

Choi, Su-jin; Kim, Dae-Kyoo; Park, Sooyong

2014-01-01

Software process improvement aims at improving the development process of software systems. It is initiated by process assessment identifying strengths and weaknesses and based on the findings, improvement plans are developed. In general, a process reference model (e.g., CMMI) is used throughout the process of software process improvement as the base. CMMI defines a set of process areas involved in software development and what to be carried out in process areas in terms of goals and practices. Process areas and their elements (goals and practices) are often correlated due to the iterative nature of software development process. However, in the current practice, correlations of process elements are often overlooked in the development of an improvement plan, which diminishes the efficiency of the plan. This is mainly attributed to significant efforts and the lack of required expertise. In this paper, we present a process correlation analysis model that helps identify correlations of process elements from the results of process assessment. This model is defined based on CMMI and empirical data of improvement practices. We evaluate the model using industrial data.

Fluoride Uptake Profiles of Selected European Toothpastes into Hard Tissues and Plaque.

Science.gov (United States)

Moore, Joel; Schneiderman, Eva; Farmer, Teresa; Zsiska, Marianne

2017-09-01

To compare the fluoridating potential of selected European toothpastes using a combination of enamel, dentin, and plaque in vitromodels. Four in vitromodels were included: 1) Enamel Fluoride (F) Uptake (EFU); 2) Dentin F Uptake (DFU); 3) Enamel Solubility Reduction (ESR); and 4) Plaque F Uptake (PFU). A core set of marketed products was included in all studies, plus a standard toothpaste (1100 ppm F as NaF/silica) and placebo control (the PFU study did not include a placebo control). Test dentifrices: [A] Fluocaril® Bi-Fluoré 250 (1500 ppm F as NaF+1000 ppm F as SMFP); [B] LacerAnticaries (2500 ppm F as SMFP); [C] Elmex® Caries Professional™ (1450 ppm F as SMFP+1.5% arginine); [D] Colgate® Triple Action (1450 ppm F as SMFP); [E] Placebo (0 ppm F); and [F] standard toothpaste (1100 ppm as NaF/silica). In all studies (EFU, DFU, ESR, and PFU), assessments were compared for each pair using the Tukey-Kramer HSD test (p F = B = C = D > E; DFU: A > F = B = C = D = E; PFU: A = B > F = C = D). In demineralization prevention, the Fluocaril dentifrice [A] also provided the greatest benefit (ESR: A = F = C = B = D > E). In all studies that included a placebo control, all of the F-containing dentifrices performed better than the placebo control. While these results demonstrate that all of the marketed products tested provide effective anticaries benefits, the Fluocaril Bi-Fluoré 250 dentifrice consistently delivered unsurpassed performance. It delivered the highest level of F to plaque, provided greater measures of efficacy in both remineralization and inhibition of demineralization, and delivered substantial improvement in fluoridation of dentin, suggesting the potential for delivering both coronal and root caries benefits.

Use of Complementary Approaches to Imaging Biomolecules and Endogenous and Exogenous Trace Elements and Nanoparticles in Biological Samples

Science.gov (United States)

Brown, Koshonna Dinettia

X-ray Fluorescence Microscopy (XFM) is a useful technique for study of biological samples. XFM was used to map and quantify endogenous biological elements as well as exogenous materials in biological samples, such as the distribution of titanium dioxide (TiO2) nanoparticles. TiO 2 nanoparticles are produced for many different purposes, including development of therapeutic and diagnostic particles for cancer detection and treatment, drug delivery, and induction of DNA breaks. Delivery of such nanoparticles can be targeted to specific cells and subcellular structures. In this work, we develop two novel approaches to stain TiO2 nanoparticles for optical microscopy and to confirm that staining by XFM. The first approach utilizes fluorescent biotin and fluorescent streptavidin to label the nanoparticles before and after cellular uptake; the second approach is based on the copper-catalyzed azide-alkyne cycloaddition, the so-called CLICK chemistry, for labeling of azide conjugated TiO2 nanoparticles with "clickable" dyes such as alkyne Alexa Fluor dyes with a high fluorescent yield. To confirm that the optical fluorescence signals of nanoparticles stained in situ match the distribution of the Ti element, we used high resolution synchrotron X-Ray Fluorescence Microscopy (XFM) using the Bionanoprobe instrument at the Advanced Photon Source at Argonne National Laboratory. Titanium-specific X-ray fluorescence showed excellent overlap with the location of Alexa Fluor optical fluorescence detected by confocal microscopy. In this work XFM was also used to investigate native elemental differences between two different types of head and neck cancer, one associated with human papilloma virus infection, the other virus free. Future work may see a cross between these themes, for example, exploration of TiO2 nanoparticles as anticancer treatment for these two different types of head and neck cancer.

[Study on application of CPP-ACP on tooth mineralization during orthodontic treatment with fixed appliance].

Science.gov (United States)

He, Wen-dan; Liu, Ying-zhi; Xu, Yuan-yuan; Chen, Dong

2010-04-01

To determine the value of clinical application of CPP-ACP during orthodontic treatment with fixed appliance. Seventy-five subjects were divided randomly into three groups, the control group, experimental group A and experimental group B. The control group were emphasized on daily oral hygiene. Experimental group A used fluor protector every three months under the dentist's guidance. Experimental group B used Casein phosphopeptide amorphous calcium phosphate(CCP-ACP) once a day. After finishing the orthodontic treatment, photos were taken under the same condition ,then the degree of the enamel's demineralization was examined and the enamel decalcification index(EDI) was calculated. SPSS11.0 software package was used for statistical analysis. (1)The incidence of three groups' enamel decalcification declined in sequence as the control group(60%),experimental group A (36%), experimental group B (32%).(2)The incidence of the teeth's enamel calcification of three groups declined in sequence as the control group(14.7%),experimental group A (8.46%), experimental group B (7.72%), the difference between the control group and two experimental groups was significant, while no significant difference was found between the two experimental groups.(3(EDI of the control group was 0.155+/-0.023, EDI of the experimental group A was 0.082+/-0.009,while EDI of the experimental group B was 0.078+/-0.006. The difference between the control group and two experimental groups was statistically significant, while was not statistically significant between the two experimental groups. The application of fluor protector and CPP-ACP can improve the mineralization of the teeth during orthodontic treatment with fixed appliance. CPP-ACP is more convenient for the patients to use. Supported by Research Fund of Bureau of Science and Technology of Futian District Shenzhen City(Grant No.FTWS056).

CLOSING IN ON CLOSURE PERSPECTIVES FROM HANFORD and FERNALD AN UPDATE

International Nuclear Information System (INIS)

CONNELL, J.D.

2004-01-01

In World War II, the arms dramatically changed from machine guns and incendiary bombs to nuclear weapons. Hanford and Fernald, two government-run sites, were part of the infrastructure established for producing the fissile material for making these weapons, as well as building a nuclear arsenal to deter future aggression by other nations. This paper compares and contrasts, from a communications point of view, these two Department of Energy (DOE) closure sites, each with Fluor as a prime contractor. The major differences between the two sites--Hanford in Washington state and Fernald in Ohio--includes the following: size of the site and the workforce, timing of closure, definition of end state, DOE oversight, proximity to population centers, readiness of local population for closure, and dependence of the local economy on the site's budget. All of these elements affect how the sites' communication professionals provide information even though the objectives are the same: build public acceptance and support for DOE's mission to accelerate cleanup, interface with stakeholders to help ensure that issues are addressed and goals are met, help workers literally work themselves out of jobs--faster, and prepare the ''host'' communities to deal with the void left when the sites are closed and the government contractors are gone. The 12-months between January 04 and January 05 have seen dramatic transformations at both sites, as Fernald is now just about a year away from closure and FLuor's work at Hanford has made the transition from operations to deactivation and demolition. While Fernald continues to clean out silos of waste and ship it off site, Hanford is dealing with recent state legislation that has the potential to significantly impact the progress of cleanup. These changes have even further accentuated the differences in the content, distribution, and impact of communications

Analysis of UV-excited fluorochromes by flow cytometry using near-ultraviolet laser diodes.

Science.gov (United States)

Telford, William G

2004-09-01

Violet laser diodes have become common and reliable laser sources for benchtop flow cytometers. While these lasers are very useful for a variety of violet and some ultraviolet-excited fluorochromes (e.g., DAPI), they do not efficiently excite most UV-stimulated probes. In this study, the next generation of InGaN near-UV laser diodes (NUVLDs) emitting in the 370-375-nm range have been evaluated as laser sources for cuvette-based flow cytometers. Several NUVLDs, ranging in wavelength from 370 to 374 nm and in power level from 1.5 to 10 mW, were mounted on a BD Biosciences LSR II and evaluated for their ability to excite cells labeled with the UV DNA binding dye DAPI, several UV phenotyping fluorochromes (including Alexa Fluor 350, Marina Blue, and quantum dots), and the fluorescent calcium chelator indo-1. NUVLDs at the 8-10-mW power range gave detection sensitivity levels comparable to more powerful solid-state and ion laser sources, using low-fluorescence microsphere beads as measurement standards. NUVLDs at all tested power levels allowed extremely high-resolution DAPI cell cycle analysis, and sources in the 8-10-mW power range excited Alexa Fluor 350, Marina Blue, and a variety of quantum dots at virtually the same signal-to-noise ratios as more powerful UV sources. These evaluations indicate that near-UV laser diodes installed on a cuvette-based flow cytometer performed nearly as well as more powerful solid-state UV lasers on the same instrumentation, and comparably to more powerful ion lasers on a jet-in-air system, and. Despite their limited power, integration of these small and inexpensive lasers into benchtop flow cytometers should allow the use of flow cytometric applications requiring UV excitation on a wide variety of instruments. Copyright 2004 Wiley-Liss, Inc.

Management of processes of electrochemical dimensional processing

Science.gov (United States)

Akhmetov, I. D.; Zakirova, A. R.; Sadykov, Z. B.

2017-09-01

In different industries a lot high-precision parts are produced from hard-processed scarce materials. Forming such details can only be acting during non-contact processing, or a minimum of effort, and doable by the use, for example, of electro-chemical processing. At the present stage of development of metal working processes are important management issues electrochemical machining and its automation. This article provides some indicators and factors of electrochemical machining process.

Chemical process engineering in the transuranium processing plant

International Nuclear Information System (INIS)

Collins, E.D.; Bigelow, J.E.

1976-01-01

Since operation of the Transuranium Processing Plant began, process changes have been made to counteract problems caused by equipment corrosion, to satisfy new processing requirements, and to utilize improved processes. The new processes, equipment, and techniques have been incorporated into a sequence of steps which satisfies all required processing functions

Hanford Waste Vitrification Plant technical manual

Energy Technology Data Exchange (ETDEWEB)

Larson, D.E. [ed.; Watrous, R.A.; Kruger, O.L. [and others

1996-03-01

A key element of the Hanford waste management strategy is the construction of a new facility, the Hanford Waste Vitrification Plant (HWVP), to vitrify existing and future liquid high-level waste produced by defense activities at the Hanford Site. The HWVP mission is to vitrify pretreated waste in borosilicate glass, cast the glass into stainless steel canisters, and store the canisters at the Hanford Site until they are shipped to a federal geological repository. The HWVP Technical Manual (Manual) documents the technical bases of the current HWVP process and provides a physical description of the related equipment and the plant. The immediate purpose of the document is to provide the technical bases for preparation of project baseline documents that will be used to direct the Title 1 and Title 2 design by the A/E, Fluor. The content of the Manual is organized in the following manner. Chapter 1.0 contains the background and context within which the HWVP was designed. Chapter 2.0 describes the site, plant, equipment and supporting services and provides the context for application of the process information in the Manual. Chapter 3.0 provides plant feed and product requirements, which are primary process bases for plant operation. Chapter 4.0 summarizes the technology for each plant process. Chapter 5.0 describes the engineering principles for designing major types of HWVP equipment. Chapter 6.0 describes the general safety aspects of the plant and process to assist in safe and prudent facility operation. Chapter 7.0 includes a description of the waste form qualification program and data. Chapter 8.0 indicates the current status of quality assurance requirements for the Manual. The Appendices provide data that are too extensive to be placed in the main text, such as extensive tables and sets of figures. The Manual is a revision of the 1987 version.

Hanford Waste Vitrification Plant technical manual

International Nuclear Information System (INIS)

Larson, D.E.; Watrous, R.A.; Kruger, O.L.

1996-03-01

A key element of the Hanford waste management strategy is the construction of a new facility, the Hanford Waste Vitrification Plant (HWVP), to vitrify existing and future liquid high-level waste produced by defense activities at the Hanford Site. The HWVP mission is to vitrify pretreated waste in borosilicate glass, cast the glass into stainless steel canisters, and store the canisters at the Hanford Site until they are shipped to a federal geological repository. The HWVP Technical Manual (Manual) documents the technical bases of the current HWVP process and provides a physical description of the related equipment and the plant. The immediate purpose of the document is to provide the technical bases for preparation of project baseline documents that will be used to direct the Title 1 and Title 2 design by the A/E, Fluor. The content of the Manual is organized in the following manner. Chapter 1.0 contains the background and context within which the HWVP was designed. Chapter 2.0 describes the site, plant, equipment and supporting services and provides the context for application of the process information in the Manual. Chapter 3.0 provides plant feed and product requirements, which are primary process bases for plant operation. Chapter 4.0 summarizes the technology for each plant process. Chapter 5.0 describes the engineering principles for designing major types of HWVP equipment. Chapter 6.0 describes the general safety aspects of the plant and process to assist in safe and prudent facility operation. Chapter 7.0 includes a description of the waste form qualification program and data. Chapter 8.0 indicates the current status of quality assurance requirements for the Manual. The Appendices provide data that are too extensive to be placed in the main text, such as extensive tables and sets of figures. The Manual is a revision of the 1987 version

The fluorescent detection of Paradiplozoon sp. (Monogenea: Diplozoidae attachment clamps' sclerites and integumental proteins : research communication

Directory of Open Access Journals (Sweden)

S.J. Milne

2006-09-01

Full Text Available In the genus Paradiplozoon, few hard structures are present therefore most of the taxonomic studies have focused on the unique ultrastructure of the sclerites. Alcohol-fixed specimens were transferred to BSA-saline for 5 min. before staining indefinitely with 5 µl WGA-TRX, 5 µl SYTO 9 and 5 µl of Cal co fluor White M2R. Rhodamine, Fluorescein and DAPI bandpass filters on the microscope enabled selective light wavelength illumination of the three flourochromes by a mercury light source. This method provided an easy and rapid methodology to show the internal sclerites of attachment clamps. It is suitable for alcohol preserved specimens and may have additional applications in other helminth organisms.

Complex logic functions implemented with quantum dot bionanophotonic circuits.

Science.gov (United States)

Claussen, Jonathan C; Hildebrandt, Niko; Susumu, Kimihiro; Ancona, Mario G; Medintz, Igor L

2014-03-26

We combine quantum dots (QDs) with long-lifetime terbium complexes (Tb), a near-IR Alexa Fluor dye (A647), and self-assembling peptides to demonstrate combinatorial and sequential bionanophotonic logic devices that function by time-gated Förster resonance energy transfer (FRET). Upon excitation, the Tb-QD-A647 FRET-complex produces time-dependent photoluminescent signatures from multi-FRET pathways enabled by the capacitor-like behavior of the Tb. The unique photoluminescent signatures are manipulated by ratiometrically varying dye/Tb inputs and collection time. Fluorescent output is converted into Boolean logic states to create complex arithmetic circuits including the half-adder/half-subtractor, 2:1 multiplexer/1:2 demultiplexer, and a 3-digit, 16-combination keypad lock.

Managing Process Variants in the Process Life Cycle

NARCIS (Netherlands)

Hallerbach, A.; Bauer, Th.; Reichert, M.U.

2007-01-01

When designing process-aware information systems, often variants of the same process have to be specified. Each variant then constitutes an adjustment of a particular process to specific requirements building the process context. Current Business Process Management (BPM) tools do not adequately

Applications of Process Synthesis: Moving from Conventional Chemical Processes towards Biorefinery Processes

DEFF Research Database (Denmark)

Yuan, Zhihong; Chen, Bingzhen; Gani, Rafiqul

2013-01-01

Concerns about diminishing petroleum reserves, enhanced worldwide demand for fuels and fluctuations in the global oil market, together with climate change and national security have promoted many initiatives for exploring alternative, non-petroleum based processes. Among these initiatives......, biorefinery processes for converting biomass-derived carbohydrates into transportation fuels and chemicals are now gaining more and more attention from both academia and industry. Process synthesis, which has played a vital role for the development, design and operation of (petro) chemical processes, can...

Visualizing the process of process modeling with PPMCharts

NARCIS (Netherlands)

Claes, J.; Vanderfeesten, I.T.P.; Pinggera, J.; Reijers, H.A.; Weber, B.; Poels, G.; La Rosa, M.; Soffer, P.

2013-01-01

In the quest for knowledge about how to make good process models, recent research focus is shifting from studying the quality of process models to studying the process of process modeling (often abbreviated as PPM) itself. This paper reports on our efforts to visualize this specific process in such

Modélisation et Spectroscopie des Vitrocéramiques Fluorées dopés par des Ions de Terres Rares pour Applications en Amplification dans l'Infrarouge

OpenAIRE

El Jouad , Mohamed

2010-01-01

This thesis concerns the characterization of rare earth doped fluoride glasses and glass ceramics. The interest of such materials and systems to achieve ultra-transparent with low losses and also with low phonon frequency avoiding the normal processes that limit the performance of laser emission. The study is based on two aspects: modeling and experimental spectroscopy. The emission spectroscopy measurements with site selection have the potential to probe the environment around the luminescen...

Process Intensification: A Perspective on Process Synthesis

DEFF Research Database (Denmark)

Lutze, Philip; Gani, Rafiqul; Woodley, John

2010-01-01

In recent years, process intensification (PI) has attracted considerable academic interest as a potential means for process improvement, to meet the increasing demands for sustainable production. A variety of intensified operations developed in academia and industry creates a large number...... of options to potentially improve the process but to identify the set of feasible solutions for PI in which the optimal can be found takes considerable resources. Hence, a process synthesis tool to achieve PI would potentially assist in the generation and evaluation of PI options. Currently, several process...... design tools with a clear focus on specific PI tasks exist. Therefore, in this paper, the concept of a general systematic framework for synthesis and design of PI options in hierarchical steps through analyzing an existing process, generating PI options in a superstructure and evaluating intensified...

Perceptual Processing Affects Conceptual Processing

Science.gov (United States)

van Dantzig, Saskia; Pecher, Diane; Zeelenberg, Rene; Barsalou, Lawrence W.

2008-01-01

According to the Perceptual Symbols Theory of cognition (Barsalou, 1999), modality-specific simulations underlie the representation of concepts. A strong prediction of this view is that perceptual processing affects conceptual processing. In this study, participants performed a perceptual detection task and a conceptual property-verification task…

A process insight repository supporting process optimization

OpenAIRE

Vetlugin, Andrey

2012-01-01

Existing solutions for analysis and optimization of manufacturing processes, such as online analysis processing or statistical calculations, have shortcomings that limit continuous process improvements. In particular, they lack means of storing and integrating the results of analysis. This makes the valuable information that can be used for process optimizations used only once and then disposed. The goal of the Advanced Manufacturing Analytics (AdMA) research project is to design an integrate...

Two-stage process analysis using the process-based performance measurement framework and business process simulation

NARCIS (Netherlands)

Han, K.H.; Kang, J.G.; Song, M.S.

2009-01-01

Many enterprises have recently been pursuing process innovation or improvement to attain their performance goals. To align a business process with enterprise performances, this study proposes a two-stage process analysis for process (re)design that combines the process-based performance measurement

Continuous Correctness of Business Processes Against Process Interference

NARCIS (Netherlands)

van Beest, Nick; Bucur, Doina

2013-01-01

In distributed business process support environments, process interference from multiple stakeholders may cause erroneous process outcomes. Existing solutions to detect and correct interference at runtime employ formal verification and the automatic generation of intervention processes at runtime.

[Clinical and microbiological study regarding surface antibacterial properties of bioactive dental materials].

Science.gov (United States)

Târcă, T; Bădescu, Aida; Topoliceanu, C; Lăcătuşu, St

2010-01-01

In the new era of dentistry the coronal restoration materials must possess "bio-active" features represented by fluor ions release, chemical adhesion and antibacterial agents. Our study aims to determine the surface antibacterial properties of glassionomer cements and compomers. The study group included 64 patients with high cariogenic risk with 80 teeth with acute and chronic dental caries affecting proximal and occlusal dental surfaces. The teeth with cariogenic lesions were restored with zinc-oxide-eugenol (n=20), glassionomer cement GC Fuji Triage (n=20), glassionomer cement modified with resins Fuji II LC (n=20), compomer Dyract (n=20). DENTOCULT SM test (Orion Diagnostica, Finland) was used for bacterial analyses. The samples from bacterial biofilm were collected from the restorated dental surfaces (study group) and intact enamel surfaces (control group). The recorded data were processed using non-parametrical statistical tests. The lowest mean value of bacterial indices was recorded for glassionomer cement Fuji Triage (0.4), and Fuji II LC (1.2), material with highest surface antibacterial properties. The highest value (1.5) was recorded for compomer Dyract. The Kruskal-Wallis test proves the significant statistical differences between the three bioactive materials. The materials with bioactive features have the ability to inhibate the growth of Streptococcus mutans in bacterial biofilm to the surfaces of coronal restoration.

Effect of radiation-induced modification in fluoroelastomer

International Nuclear Information System (INIS)

Zen, Heloisa Augusto; Lugao, Ademar Benevolo

2013-01-01

Polymers exposed to ionizing irradiation, even at low doses, often undergo structural changes accompanied by molecular crosslinking and chain scission (degradation) reactions. The general effect of the radiation on polymers is determined by the ratio of crosslinking to chain scission events. This ratio depends on parameters such as chemical structure, physical state, radicals stability and mobility, irradiation rate and irradiation atmosphere. The radiation process is a large used technique to promote modification in their structures to apply them in different areas and is well known for its merits and potential in modifying the chemical and the physical properties of polymeric materials without cause drastic changes in their inherent properties, depend on the dose irradiated. In this study was used fluoroelastomer with 70% - fluor that having excellent thermal, chemical and mechanical properties. Vulcanized and non-vulcanized samples of this material were submitted to gamma radiation under air atmosphere in order to observe the effect of atmosphere in the polymer matrix. The irradiated doses were 5, 10 and 20kGy, at room temperature. The characterization was made by scanning electron microscope (SEM), infrared spectroscopy using attenuate reflectance (ATR-IR) and X-ray diffraction. The results demonstrated which was expected, the degradation reactions were observed. (author)

In Vivo Dual Fluorescence Imaging to Detect Joint Destruction.

Science.gov (United States)

Cho, Hongsik; Bhatti, Fazal-Ur-Rehman; Lee, Sangmin; Brand, David D; Yi, Ae-Kyung; Hasty, Karen A

2016-10-01

Diagnosis of cartilage damage in early stages of arthritis is vital to impede the progression of disease. In this regard, considerable progress has been made in near-infrared fluorescence (NIRF) optical imaging technique. Arthritis can develop due to various mechanisms but one of the main contributors is the production of matrix metalloproteinases (MMPs), enzymes that can degrade components of the extracellular matrix. Especially, MMP-1 and MMP-13 have main roles in rheumatoid arthritis and osteoarthritis because they enhance collagen degradation in the process of arthritis. We present here a novel NIRF imaging strategy that can be used to determine the activity of MMPs and cartilage damage simultaneously by detection of exposed type II collagen in cartilage tissue. In this study, retro-orbital injection of mixed fluorescent dyes, MMPSense 750 FAST (MMP750) dye and Alexa Fluor 680 conjugated monoclonal mouse antibody immune-reactive to type II collagen, was administered in the arthritic mice. Both dyes were detected with different intensity according to degree of joint destruction in the animal. Thus, our dual fluorescence imaging method can be used to detect cartilage damage as well as MMP activity simultaneously in early stage arthritis. © 2016 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

The effect of clay incorporation on the mechanical properties of fluoroelastomer

International Nuclear Information System (INIS)

Zen, Heloisa Augusto; Oliveira, Jonathan Pereira de; Lugao, Ademar Benevolo

2015-01-01

In this work was studied the effect of clay incorporation in the mechanical properties of fluoroelastomer (FKM). The polymer matrix that was used is a compound of the commercial terpolymer of hexafluoropropylene, vinylidene fluoride and tetrafluoroethylene, with 70% of fluor content. This type of polymer is known for its resistance to high temperature and chemical products; it has low fuel permeation which allowing be used as sealant and especially as o-ring product. The incorporation of clay was carried to avoid excessive swelling and to observe the effect in the mechanical properties, for this application was used commercial clay, Cloisite® at 1 and 2% in weigh. The incorporation of clay into the FKM was carried out in a two roll cylinder. After that, the samples with and without clay loading were submitted to gamma radiation at 20 kGy in order to observe the changes in the polymer matrix. The characterization techniques used were: mechanical testes (stress - strain), rheometric properties and degree of swelling. After radiation process, was observed an increase in the swelling degree for the irradiated samples in relation to the pristine one. The incorporated samples with 1 and 2% of clay showed an increase in the elongation which can indicate a decrease in hardness of the polymer matrix. (author)

Disruption of the actin cytoskeleton results in the promotion of gravitropism in inflorescence stems and hypocotyls of Arabidopsis

Science.gov (United States)

Yamamoto, Kazuyoshi; Kiss, John Z.

2002-01-01

The actin cytoskeleton is hypothesized to play a major role in gravity perception and transduction mechanisms in roots of plants. To determine whether actin microfilaments (MFs) are involved in these processes in stem-like organs, we studied gravitropism in Arabidopsis inflorescence stems and hypocotyls. Localization studies using Alexa Fluor-phalloidin in conjugation with confocal microscopy demonstrated a longitudinally and transversely oriented actin MF network in endodermal cells of stems and hypocotyls. Latrunculin B (Lat-B) treatment of hypocotyls caused depolymerization of actin MFs in endodermal cells and a significant reduction of hypocotyl growth rates. Actin MFs in Lat-B-treated inflorescence stems also were disrupted, but growth rates were not affected. Despite disruption of the actin cytoskeleton in these two organs, Lat-B-treated stems and hypocotyls exhibited a promotion of gravitropic curvature in response to reorientation. In contrast, Lat-B reduced gravitropic curvature in roots but also reduced the growth rate. Thus, in contrast to prevailing hypotheses, our results suggest that actin MFs are not a necessary component of gravitropism in inflorescence stems and hypocotyls. Furthermore, this is the first study to demonstrate a prominent actin MF network in endodermal cells in the putative gravity-perceiving cells in stems.

Process mining: making knowledge discovery process centric

NARCIS (Netherlands)

Aalst, van der W.M.P.

2011-01-01

Recently, the Task Force on Process Mining released the Process Mining Manifesto. The manifesto is supported by 53 organizations and 77 process mining experts contributed to it. The active contributions from end-users, tool vendors, consultants, analysts, and researchers illustrate the growing

Business process model repositories : efficient process retrieval

NARCIS (Netherlands)

Yan, Z.

2012-01-01

As organizations increasingly work in process-oriented manner, the number of business process models that they develop and have to maintain increases. As a consequence, it has become common for organizations to have collections of hundreds or even thousands of business process models. When a

Aerodynamic isotope separation processes for uranium enrichment: process requirements

International Nuclear Information System (INIS)

Malling, G.F.; Von Halle, E.

1976-01-01

The pressing need for enriched uranium to fuel nuclear power reactors, requiring that as many as ten large uranium isotope separation plants be built during the next twenty years, has inspired an increase of interest in isotope separation processes for uranium enrichment. Aerodynamic isotope separation processes have been prominently mentioned along with the gas centrifuge process and the laser isotope separation methods as alternatives to the gaseous diffusion process, currently in use, for these future plants. Commonly included in the category of aerodynamic isotope separation processes are: (a) the separation nozzle process; (b) opposed gas jets; (c) the gas vortex; (d) the separation probes; (e) interacting molecular beams; (f) jet penetration processes; and (g) time of flight separation processes. A number of these aerodynamic isotope separation processes depend, as does the gas centrifuge process, on pressure diffusion associated with curved streamlines for the basic separation effect. Much can be deduced about the process characteristics and the economic potential of such processes from a simple and elementary process model. In particular, the benefit to be gained from a light carrier gas added to the uranium feed is clearly demonstrated. The model also illustrates the importance of transient effects in this class of processes

Business Process Innovation using the Process Innovation Laboratory

DEFF Research Database (Denmark)

Møller, Charles

for practical applications has not been identified. The aim of this paper is to establish a conceptual framework for business process innovation in the supply chain based on advanced enterprise systems. The main approach to business process innovation in this context is to create a new methodology for exploring...... process models and patterns of applications. The paper thus presents a new concept for business process innovation called the process innovation laboratory a.k.a. the ?-Lab. The ?-Lab is a comprehensive framework for BPI using advanced enterprise systems. The ?-Lab is a collaborative workspace...... for experimenting with process models and an explorative approach to study integrated modeling in a controlled environment. The ?-Lab facilitates innovation by using an integrated action learning approach to process modeling including contemporary technological, organizational and business perspectives....

Discovering Reference Process Models by Mining Process Variants

NARCIS (Netherlands)

Li, C.; Reichert, M.U.; Wombacher, Andreas

Recently, a new generation of adaptive Process-Aware Information Systems (PAIS) has emerged, which allows for dynamic process and service changes (e.g., to insert, delete, and move activities and service executions in a running process). This, in turn, has led to a large number of process variants

BUSINESS PROCESS REENGINEERING AS THE METHOD OF PROCESS MANAGEMENT

Directory of Open Access Journals (Sweden)

O. Honcharova

2013-09-01

Full Text Available The article is devoted to the analysis of process management approach. The main understanding of process management approach has been researched in the article. The definition of process and process management has been given. Also the methods of business process improvement has been analyzed, among them are fast-analysis solution technology (FAST, benchmarking, reprojecting and reengineering. The main results of using business process improvement have been described in figures of reducing cycle time, costs and errors. Also the tasks of business process reengineering have been noticed. The main stages of business process reengineering have been noticed. The main efficiency results of business process reengineering and its success factors have been determined.

Fundamentals of process intensification: A process systems engineering view

DEFF Research Database (Denmark)

Babi, Deenesh Kavi; Sales Cruz, Alfonso Mauricio; Gani, Rafiqul

2016-01-01

This chapter gives an overview of the fundamentals of process intensification from a process systems engineering point of view. The concept of process intensification, including process integration, is explained together with the drivers for applying process intensification, which can be achieved...

Idaho Chemical Processing Plant Process Efficiency improvements

International Nuclear Information System (INIS)

Griebenow, B.

1996-03-01

In response to decreasing funding levels available to support activities at the Idaho Chemical Processing Plant (ICPP) and a desire to be cost competitive, the Department of Energy Idaho Operations Office (DOE-ID) and Lockheed Idaho Technologies Company have increased their emphasis on cost-saving measures. The ICPP Effectiveness Improvement Initiative involves many activities to improve cost effectiveness and competitiveness. This report documents the methodology and results of one of those cost cutting measures, the Process Efficiency Improvement Activity. The Process Efficiency Improvement Activity performed a systematic review of major work processes at the ICPP to increase productivity and to identify nonvalue-added requirements. A two-phase approach was selected for the activity to allow for near-term implementation of relatively easy process modifications in the first phase while obtaining long-term continuous improvement in the second phase and beyond. Phase I of the initiative included a concentrated review of processes that had a high potential for cost savings with the intent of realizing savings in Fiscal Year 1996 (FY-96.) Phase II consists of implementing long-term strategies too complex for Phase I implementation and evaluation of processes not targeted for Phase I review. The Phase II effort is targeted for realizing cost savings in FY-97 and beyond

Hyaluronic Acid in Normal and Neoplastic Colorectal Tissue: Electrospray Ionization Mass Spectrometric and Fluor Metric Analysis

Directory of Open Access Journals (Sweden)

Ana Paula Cleto Marolla

2016-01-01

Conclusions: The expression of HA was found to be slightly lower in tumor tissue than in colorectal non-neoplastic mucosa, although this difference was not statistically significant. This finding probably influenced the lower expression of HA in tumor tissue than in colorectal non-neoplastic mucosa. Compared to normal tissues, HA levels are significantly increased in the tumor tissues unless they exhibit lymph node metastasis. Otherwise, the expression of HA in tumor tissue did not correlated with the other clinicopathological parameters.

The effect of CPP-ACP containing fluoride on Streptococcus mutans adhesion and enamel roughness

Directory of Open Access Journals (Sweden)

Yulita Kristanti

2013-12-01

aplikasi CPP-ACP mengandung fluor sebelum dan setelah bleaching terhadap adhesi S.mutans dan kekasaran enamel. Metode: Sampel penelitian adalah 6 buah gigi yang dibagi dalam 4 kelompok, kemudian masing-masing gigi dibelah menjadi 4 bagian. Kelompok A dan C diaplikasi dengan CPP-ACP setelah bleaching, sedang Kelompok B dan D diaplikasi CPP-ACP sebelum dan setelah bleaching. CPP-ACP yang digunakan pada kelompok C dan D adalah yang mengandung fluor. Setelah perlakuan, semua sampel disterilkan dan direndam dalam saliva steril, lalu direndam dalam suspensi S. mutans 108 CFU dan diinkubasi 24 jam. Hari berikutnya sampel dimasukkan dalam BHI steril, divortex 1 menit untuk melepaskan bakteri. Lima belas ml BHI yang berisi S. mutans tersebut diambil untuk dikultur dalam agar TYS dan diinkubasi 37°C selama 48 jam. Bakteri yang tumbuh dihitung dengan colony counter. Pemeriksaan SEM dilakukan untuk meneliti permukaan enamel. Hasil: Aplikasi CPP-ACP(F menurunkan jumlah bakteri yang melekat pada enamel secara signifikan (p<0,05 pada semua kelompok, kecuali antara kelompok A dan C. Simpulan: Aplikasi CPP-ACP mengandung fluor sebelum dan sesudah bleaching efektif mengurangi akumulasi S. mutans dan kekasaran pada permukaan enamel.

Verres et vitrocéramiques fluorés dopés terre rare et/ou métal de transition pour la conversion de l'énergie solaire

OpenAIRE

Maalej , Olfa

2015-01-01

The efficiency of solar cells can be improved by fully exploiting the UV-blue portion of the solar spectrum, through a frequency converting mechanism of type downconversion. This process using energy transfer between rare earth ions (RE) or 3d transition metal (pairs RE3+/Yb3+ with TR = Pr, Tm,… and Cr3+/Yb3+) requires a matrix with low phonon energy to reduce non radiative relaxation.So far, the studied materials are mainly in the form of polycristalline powder, which limits their use due to...

Process Accounting

OpenAIRE

Gilbertson, Keith

2002-01-01

Standard utilities can help you collect and interpret your Linux system's process accounting data. Describes the uses of process accounting, standard process accounting commands, and example code that makes use of process accounting utilities.

Post-modification by γ-radiation of VDF-based polymers: Electrochemical capacitor membrane application

International Nuclear Information System (INIS)

Dumas, L.

2012-01-01

This work deals with the modification of VDF-based polymer induced by γ-radiation as the polymer may be used in electrochemical super-capacitors. The main objective was to limit the swelling of the fluorinated matrix with a given electrolyte while a good wetting of the polymer by the liquid was also required. As the main basic process involved in polymer radiolysis is the formation of radicals, a part of the work was dedicated to the study of such species by using Electron Spin Resonance spectroscopy. A simulation model of ESR spectra was established in order to identify and quantify each radical species. The effect of several parameters such as radiation dose, annealing time or the nature of polymer matrix on the concentration of each species where investigated. A relation with the evolution of the crosslink density of the network formed during the radiolysis was proposed. In addition, one of the key steps of this work was to study the radiation crosslinking ability of VDF-based polymers and find a way to increase the crosslink density. This was achieved by incorporating, prior to the radiation process, a radiation sensitive cross linker: TAIC. Finally, a new strategy based on the modification of surface properties of PVDF was investigated. It consists in the radiation grafting of penta-fluor-styrene onto PVDF surface followed by the chemo-selective functionalization of the grafted segments. As a conclusion, the different approaches used in this thesis allowed us to understand the radiolysis of VDF-based polymers and take advantage of the elementary process involved in this type of chemistry, to build up robust and promising strategies for tuning properties. (author)

Modeling of biopharmaceutical processes. Part 2: Process chromatography unit operation

DEFF Research Database (Denmark)

Kaltenbrunner, Oliver; McCue, Justin; Engel, Philip

2008-01-01

Process modeling can be a useful tool to aid in process development, process optimization, and process scale-up. When modeling a chromatography process, one must first select the appropriate models that describe the mass transfer and adsorption that occurs within the porous adsorbent. The theoret......Process modeling can be a useful tool to aid in process development, process optimization, and process scale-up. When modeling a chromatography process, one must first select the appropriate models that describe the mass transfer and adsorption that occurs within the porous adsorbent...

Generalized Ornstein-Uhlenbeck processes and associated self-similar processes

CERN Document Server

Lim, S C

2003-01-01

We consider three types of generalized Ornstein-Uhlenbeck processes: the stationary process obtained from the Lamperti transformation of fractional Brownian motion, the process with stretched exponential covariance and the process obtained from the solution of the fractional Langevin equation. These stationary Gaussian processes have many common properties, such as the fact that their local covariances share a similar structure and they exhibit identical spectral densities at large frequency limit. In addition, the generalized Ornstein-Uhlenbeck processes can be shown to be local stationary representations of fractional Brownian motion. Two new self-similar Gaussian processes, in addition to fractional Brownian motion, are obtained by applying the (inverse) Lamperti transformation to the generalized Ornstein-Uhlenbeck processes. We study some of the properties of these self-similar processes such as the long-range dependence. We give a simulation of their sample paths based on numerical Karhunan-Loeve expansi...

Generalized Ornstein-Uhlenbeck processes and associated self-similar processes

International Nuclear Information System (INIS)

Lim, S C; Muniandy, S V

2003-01-01

We consider three types of generalized Ornstein-Uhlenbeck processes: the stationary process obtained from the Lamperti transformation of fractional Brownian motion, the process with stretched exponential covariance and the process obtained from the solution of the fractional Langevin equation. These stationary Gaussian processes have many common properties, such as the fact that their local covariances share a similar structure and they exhibit identical spectral densities at large frequency limit. In addition, the generalized Ornstein-Uhlenbeck processes can be shown to be local stationary representations of fractional Brownian motion. Two new self-similar Gaussian processes, in addition to fractional Brownian motion, are obtained by applying the (inverse) Lamperti transformation to the generalized Ornstein-Uhlenbeck processes. We study some of the properties of these self-similar processes such as the long-range dependence. We give a simulation of their sample paths based on numerical Karhunan-Loeve expansion

From Process Understanding to Process Control

NARCIS (Netherlands)

Streefland, M.

2010-01-01

A licensed pharmaceutical process is required to be executed within the validated ranges throughout the lifetime of product manufacturing. Changes to the process usually require the manufacturer to demonstrate that the safety and efficacy of the product remains unchanged. Recent changes in the

Integrated Process Modeling-A Process Validation Life Cycle Companion.

Science.gov (United States)

Zahel, Thomas; Hauer, Stefan; Mueller, Eric M; Murphy, Patrick; Abad, Sandra; Vasilieva, Elena; Maurer, Daniel; Brocard, Cécile; Reinisch, Daniela; Sagmeister, Patrick; Herwig, Christoph

2017-10-17

During the regulatory requested process validation of pharmaceutical manufacturing processes, companies aim to identify, control, and continuously monitor process variation and its impact on critical quality attributes (CQAs) of the final product. It is difficult to directly connect the impact of single process parameters (PPs) to final product CQAs, especially in biopharmaceutical process development and production, where multiple unit operations are stacked together and interact with each other. Therefore, we want to present the application of Monte Carlo (MC) simulation using an integrated process model (IPM) that enables estimation of process capability even in early stages of process validation. Once the IPM is established, its capability in risk and criticality assessment is furthermore demonstrated. IPMs can be used to enable holistic production control strategies that take interactions of process parameters of multiple unit operations into account. Moreover, IPMs can be trained with development data, refined with qualification runs, and maintained with routine manufacturing data which underlines the lifecycle concept. These applications will be shown by means of a process characterization study recently conducted at a world-leading contract manufacturing organization (CMO). The new IPM methodology therefore allows anticipation of out of specification (OOS) events, identify critical process parameters, and take risk-based decisions on counteractions that increase process robustness and decrease the likelihood of OOS events.

Assessment of the Grouted IXC Monolith in Support of K East Basin Hazard Categorization

Energy Technology Data Exchange (ETDEWEB)

Short, Steven M.; Dodson, Michael G.; Alzheimer, James M.; Meyer, Perry A.

2007-10-12

Addendum to original report updating the structural analysis of the I-beam accident to reflect a smaller I-beam than originally assumed (addendum is 2 pages). The K East Basin currently contains six ion exchange columns (IXCs) that were removed from service over 10 years ago. Fluor Hanford plans to immobilize the six ion exchange columns (IXCs) in place in a concrete monolith. PNNL performed a structural assessment of the concrete monolith to determine its capability to absorb the forces imposed by postulated accidents and protect the IXCs from damage and thus prevent a release of radioactive material. From this assessment, design specifications for the concrete monolith were identified that would prevent a release of radioactive material for any of the postulated hazardous conditions.

Cherenkov and scintillation light separation in organic liquid scintillators

Energy Technology Data Exchange (ETDEWEB)

Caravaca, J.; Descamps, F.B.; Land, B.J.; Orebi Gann, G.D. [University of California, Berkeley, CA (United States); Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Yeh, M. [Brookhaven National Laboratory, Upton, NY (United States)

2017-12-15

The CHErenkov/Scintillation Separation experiment (CHESS) has been used to demonstrate the separation of Cherenkov and scintillation light in both linear alkylbenzene (LAB) and LAB with 2 g/L of PPO as a fluor (LAB/PPO). This is the first successful demonstration of Cherenkov light detection from the more challenging LAB/PPO cocktail and improves on previous results for LAB. A time resolution of 338 ± 12 ps FWHM results in an efficiency for identifying Cherenkov photons in LAB/PPO of 70 ± 3% and 63 ± 8% for time- and charge-based separation, respectively, with scintillation contamination of 36 ± 5% and 38 ± 4. LAB/PPO data is consistent with a rise time of τ{sub r} = 0.72 ± 0.33 ns. (orig.)

Neutron activation analysis of new botanical reference materials. Pt. 2

International Nuclear Information System (INIS)

Kucera, J.; Soukal, L.

1993-01-01

The certified, information, and other values of elemental contents were compared with results of neutron activation analysis (NAA) for the new Czechoslovak botanical reference materials (RMs) Green Algae 12-02-02, Lucerne 12-02-03, Wheat Bread Fluor 12-02-04, and Rye Bread Flour 12-02-05. These were prepared by the Institute of Radioecology and Applied Nuclear Techniques (IRANT), Kosice, and statistically evaluated after interlaboratory comparisons. For the majority of elements, a very good agreement was found between the IRANT values and the results of NAA. In several cases, however, significant differences were detected; possible analytical reasons for the differences and the suitability of a purely statistical evaluation of intercomparison results without analytical considerations for RM certification are discussed. (orig.)

The power of Indonesian coal

Energy Technology Data Exchange (ETDEWEB)

Rosiak, T. [Duke/Fluor Daniel (United States)

2003-02-01

The paper presents three Indonesian projects carried out by Duke/Fluor Daniel whose unique construction and operation have demonstrated the versatility and value of coal-fired power generation. These are: the construction of units 7 and 8 of the Paiton Private Power Project, a 1230 MW pulverised coal plant in Paiton, East Java; construction of a coal fired generation plant and transmission system to provide power for the expansion of a copper and gold mine on the island of Papua; and construction of four 28 MW pulverized coal units to provide 'heavy lifting' for a new mine at Batu Hijau on the island of Sumbawa. Coal was found to cost less than diesel for power generation. 2 photos.

Quantification of protein based on single-molecule counting by total internal reflection fluorescence microscopy with adsorption equilibrium

International Nuclear Information System (INIS)

Wang Lei; Xu Guang; Shi Zhikun; Jiang Wei; Jin Wenrui

2007-01-01

We developed a sensitive single-molecule imaging method for quantification of protein by total internal reflection fluorescence microscopy with adsorption equilibrium. In this method, the adsorption equilibrium of protein was achieved between solution and glass substrate. Then, fluorescence images of protein molecules in a evanescent wave field were taken by a highly sensitive electron multiplying charge coupled device. Finally, the number of fluorescent spots corresponding to the protein molecules in the images was counted. Alexa Fluor 488-labeled goat anti-rat IgG(H + L) was chosen as the model protein. The spot number showed an excellent linear relationship with protein concentration. The concentration linear range was 5.4 x 10 -11 to 8.1 x 10 -10 mol L -1

Environmental Management Performance Report April 2000

Energy Technology Data Exchange (ETDEWEB)

EDER, D.M.

2000-04-01

The purpose of the Environmental Management Performance Report (EMPR) is to provide the Department of Energy Richland Operations Office's (DOE-RL's) report of Hanford's Environmental Management (EM) performance by: Project Hanford Management Contract (PHMC) through Fluor Hanford, Inc. (FHI) and its subcontractors; Environmental Restoration Contract through Bechtel Hanford, Inc. (BHI), and its subcontractors; Pacific Northwest National Laboratories (PNNL) for EM and EM Science and Technology (S and T) Mission; and Office of Safety Regulation of the TWRS Privatization Contractor. This report is a monthly publication that summarizes EM Site performance under RL Operations Office. It is organized by the four sections listed above, with each section containing an Executive Summary and Area Performance Summaries.

The uranium of two 'private': from Jouac (Haute-Vienne) to Bertholene (Aveyron) through Saint-Pierre (Cantal)

International Nuclear Information System (INIS)

Guiollard, P.Ch.; Milville, G.

2003-01-01

In this book, the author tells us the short but intense history of some French uranium mines among the most famous ones: Jouac-Le Bernardan (Limousin) and Bertholene (Aveyron). It gives also a precious description of the discovery of the spar-fluor ore of La Charbonniere mine (Haute-Vienne) initially discovered thanks to its radioactivity (anthozonite bed) and which supplied a huge amount of fluorine. It presents the main companies (Scumra and Charbonnages du Dong-Trieu) which have exploited these deposits and also some less-known uranium mines of Aveyron, Creuse, Correze, Cantal and Limousin. The text is fully illustrated with cross sections and photos and gathers a large amount of geological and historical documents about mining techniques. (J.S.)

Cherenkov and scintillation light separation in organic liquid scintillators

International Nuclear Information System (INIS)

Caravaca, J.; Descamps, F.B.; Land, B.J.; Orebi Gann, G.D.; Yeh, M.

2017-01-01

The CHErenkov/Scintillation Separation experiment (CHESS) has been used to demonstrate the separation of Cherenkov and scintillation light in both linear alkylbenzene (LAB) and LAB with 2 g/L of PPO as a fluor (LAB/PPO). This is the first successful demonstration of Cherenkov light detection from the more challenging LAB/PPO cocktail and improves on previous results for LAB. A time resolution of 338 ± 12 ps FWHM results in an efficiency for identifying Cherenkov photons in LAB/PPO of 70 ± 3% and 63 ± 8% for time- and charge-based separation, respectively, with scintillation contamination of 36 ± 5% and 38 ± 4. LAB/PPO data is consistent with a rise time of τ r = 0.72 ± 0.33 ns. (orig.)

A fluorescence scanning electron microscope

International Nuclear Information System (INIS)

Kanemaru, Takaaki; Hirata, Kazuho; Takasu, Shin-ichi; Isobe, Shin-ichiro; Mizuki, Keiji; Mataka, Shuntaro; Nakamura, Kei-ichiro

2009-01-01

Fluorescence techniques are widely used in biological research to examine molecular localization, while electron microscopy can provide unique ultrastructural information. To date, correlative images from both fluorescence and electron microscopy have been obtained separately using two different instruments, i.e. a fluorescence microscope (FM) and an electron microscope (EM). In the current study, a scanning electron microscope (SEM) (JEOL JXA8600 M) was combined with a fluorescence digital camera microscope unit and this hybrid instrument was named a fluorescence SEM (FL-SEM). In the labeling of FL-SEM samples, both Fluolid, which is an organic EL dye, and Alexa Fluor, were employed. We successfully demonstrated that the FL-SEM is a simple and practical tool for correlative fluorescence and electron microscopy.

Fernald incident underscores DOE cleanup woes

International Nuclear Information System (INIS)

Lobsenz, G.

1994-01-01

Miscalculations and poor safety planning led to a large release of deadly gas during an error-plagued effort to plug a leaking uranium hexafluoride canister discovered lying in a scrap heap at the Energy Department's Fernald plant last year, according to a DOE investigative report. Investigators with DOE's Office of Environment, Safety and Health said serious injury was avoided only because the wind happened to blow the toxic cloud of hydrogen fluoride gas away from inadequately protected Fernald workers watching the July 1993 canister-plugging operation at the Ohio plant. The investigators said the 25-minute canister repair effort - captured on videotape - was marked by poor planning by the Fernald Environmental Restoration Management Corp. (FERMCO), a Fluor Daniel subsidiary hired by DOE for its cleanup expertise

Microcircuit Device Reliability. Digital Evaluation and Failure Analysis Data. Parts 1 and 2, Summer 1980

Science.gov (United States)

1980-01-01

C - 7403 24 :0170C v V ISCTC :o IO a - TVYPCYC :-06r 50 ISO 1±8-U3 42: : 0: ,I~ 4 : I VCVC -2010C MOI- 0ST C"’IO C6SC -MS-883 - 42: 0: - - :V 96i’&u...FINE LK :HE 5.S-8 : MS- 8583 : 64: 60l 1 : : :V . :60 -h-1N : 101-4 A : . : :GkOSSLK :FLUOR 125C Ih-S-3 64: 0, * . : V : 31 : lu14 C : T.I. : E...5.4 . : : : 1 035110J SVARIOUS : DIP :5 .35/76 :.VIS INS :±150: : 0* ± 74122 ± 14 :0/70C : I : ± N.E. "" . . - :S4F E4 :025C 070C ISO :5± 0

Poly(amino acid) functionalized maghemite and gold nanoparticles

International Nuclear Information System (INIS)

Perego, Davide; Manuel Domínguez-Vera, José; Gálvez, Natividad; Masciocchi, Norberto; Guagliardi, Antonietta

2013-01-01

Bimodal MRI/OI imaging probes are of great interest in nanomedicine. Although many organic polymers have been studied thoroughly for in vivo applications, reports on the use of poly(amino acid)s as coating polymers are scarce. In this paper, poly-(d-glutamic acid, d-lysine) (PGL) has been used for coating maghemite and gold nanoparticles. An advantage of this flexible and biocompatible polymer is that, once anchored to the nanoparticle surface, dangling lysine amino groups are available for the incorporation of new functionalities. As an example, Alexa Fluor derivatives have been attached to PGL-coated maghemite nanoparticles to obtain magnetic/fluorescent materials. These dual-property materials could be used as bimodal MRI/OI probes for in vivo imaging. (paper)

Systems and methods for imaging using radiation from laser produced plasmas

Science.gov (United States)

Renard-Le Galloudec, Nathalie; Cowan, Thomas E.; Sentoku, Yasuhiko; Rassuchine, Jennifer

2009-06-30

In particular embodiments, the present disclosure provides systems and methods for imaging a subject using radiation emitted from a laser produced plasma generating by irradiating a target with a laser. In particular examples, the target includes at least one radiation enhancing component, such as a fluor, cap, or wire. In further examples, the target has a metal layer and an internal surface defining an internal apex, the internal apex of less than about 15 .mu.m, such as less than about 1 .mu.m. The targets may take a variety of shapes, including cones, pyramids, and hemispheres. Certain aspects of the present disclosure provide improved imaging of a subject, such as improved medical images of a radiation dose than typical conventional methods and systems.

Site Outcomes Baseline Multi Year Work Plan Volume 1, River Corridor Restoration Baseline

International Nuclear Information System (INIS)

Wintczak, T.M.

2001-01-01

The River Corridor Restoration volume is a compilation of Hanford Site scope, which excludes the approximately 194 km 2 Central Plateau. The River Corridor scope is currently contractually assigned to Fluor Hanford, Bechtel Hanford, inc., DynCorp, and Pacific Northwest National Laboratory, and others. The purpose of this project specification is to provide an overall scoping document for the River Corridor Restoration volume, and to provide a link with the overall Hanford Site River Corridor scope. Additionally, this specification provides an integrated and consolidated source of information for the various scopes, by current contract, for the River Corridor Restoration Baseline. It identifies the vision, mission, and goals, as well as the operational history of the Hanford Site, along with environmental setting and hazards

PC image processing

International Nuclear Information System (INIS)

Hwa, Mok Jin Il; Am, Ha Jeng Ung

1995-04-01

This book starts summary of digital image processing and personal computer, and classification of personal computer image processing system, digital image processing, development of personal computer and image processing, image processing system, basic method of image processing such as color image processing and video processing, software and interface, computer graphics, video image and video processing application cases on image processing like satellite image processing, color transformation of image processing in high speed and portrait work system.

Meat Processing.

Science.gov (United States)

Legacy, Jim; And Others

This publication provides an introduction to meat processing for adult students in vocational and technical education programs. Organized in four chapters, the booklet provides a brief overview of the meat processing industry and the techniques of meat processing and butchering. The first chapter introduces the meat processing industry and…

Process for improving metal production in steelmaking processes

Science.gov (United States)

Pal, Uday B.; Gazula, Gopala K. M.; Hasham, Ali

1996-01-01

A process and apparatus for improving metal production in ironmaking and steelmaking processes is disclosed. The use of an inert metallic conductor in the slag containing crucible and the addition of a transition metal oxide to the slag are the disclosed process improvements.

Genetic Process Mining: Alignment-based Process Model Mutation

NARCIS (Netherlands)

Eck, van M.L.; Buijs, J.C.A.M.; Dongen, van B.F.; Fournier, F.; Mendling, J.

2015-01-01

The Evolutionary Tree Miner (ETM) is a genetic process discovery algorithm that enables the user to guide the discovery process based on preferences with respect to four process model quality dimensions: replay fitness, precision, generalization and simplicity. Traditionally, the ETM algorithm uses

Business process modeling for processing classified documents using RFID technology

Directory of Open Access Journals (Sweden)

Koszela Jarosław

2016-01-01

Full Text Available The article outlines the application of the processing approach to the functional description of the designed IT system supporting the operations of the secret office, which processes classified documents. The article describes the application of the method of incremental modeling of business processes according to the BPMN model to the description of the processes currently implemented (“as is” in a manual manner and target processes (“to be”, using the RFID technology for the purpose of their automation. Additionally, the examples of applying the method of structural and dynamic analysis of the processes (process simulation to verify their correctness and efficiency were presented. The extension of the process analysis method is a possibility of applying the warehouse of processes and process mining methods.

Novel process windows, part 1: Boosted micro process technology

NARCIS (Netherlands)

Hessel, V.; Wang, Q.

2011-01-01

Novel Process Windows (NPW) is the use of highly intensified, unusual and typically harsh process conditions to boost micro process technology and flow chemistry for the production of high-added value fine chemicals, pharmaceuticals, etc.. It is far from conventional processing and also from

Cognitive Processes in Discourse Comprehension: Passive Processes, Reader-Initiated Processes, and Evolving Mental Representations

Science.gov (United States)

van den Broek, Paul; Helder, Anne

2017-01-01

As readers move through a text, they engage in various types of processes that, if all goes well, result in a mental representation that captures their interpretation of the text. With each new text segment the reader engages in passive and, at times, reader-initiated processes. These processes are strongly influenced by the readers'…

Data processing

CERN Document Server

Fry, T F

2013-01-01

Data Processing discusses the principles, practices, and associated tools in data processing. The book is comprised of 17 chapters that are organized into three parts. The first part covers the characteristics, systems, and methods of data processing. Part 2 deals with the data processing practice; this part discusses the data input, output, and storage. The last part discusses topics related to systems and software in data processing, which include checks and controls, computer language and programs, and program elements and structures. The text will be useful to practitioners of computer-rel

In-process and post-process measurements of drill wear for control of the drilling process

Science.gov (United States)

Liu, Tien-I.; Liu, George; Gao, Zhiyu

2011-12-01

Optical inspection was used in this research for the post-process measurements of drill wear. A precision toolmakers" microscope was used. Indirect index, cutting force, is used for in-process drill wear measurements. Using in-process measurements to estimate the drill wear for control purpose can decrease the operation cost and enhance the product quality and safety. The challenge is to correlate the in-process cutting force measurements with the post-process optical inspection of drill wear. To find the most important feature, the energy principle was used in this research. It is necessary to select only the cutting force feature which shows the highest sensitivity to drill wear. The best feature selected is the peak of torque in the drilling process. Neuro-fuzzy systems were used for correlation purposes. The Adaptive-Network-Based Fuzzy Inference System (ANFIS) can construct fuzzy rules with membership functions to generate an input-output pair. A 1x6 ANFIS architecture with product of sigmoid membership functions can in-process measure the drill wear with an error as low as 0.15%. This is extremely important for control of the drilling process. Furthermore, the measurement of drill wear was performed under different drilling conditions. This shows that ANFIS has the capability of generalization.

Quasi-Birth-and-Death Processes with Rational Arrival Process Components

DEFF Research Database (Denmark)

Bean, Nigel G.; Nielsen, Bo Friis

to develop an analytic method for such a process, that parallels the analysis of a traditional QBD. We demonstrate the analysis by considering a queue where the arrival process and the sequence of service times are derived from two different RAPs that are not just Markovian Arrival processes. We also...... introduce an element of correlation between the arrival process and the sequence of service times.......In this paper we introduce the concept of a Quasi-Birth-and-Death process (QBD) with Rational Arrival Process components. We use the physical interpretation of a Rational Arrival Process (RAP), developed by Asmussen and Bladt, to consider such a Markov process. We exploit this interpretation...

Processes subject to integrated pollution control. Petroleum processes: oil refining and associated processes

International Nuclear Information System (INIS)

1995-01-01

This document, part of a series offering guidance on pollution control regulations issued by Her Majesty's Inspectorate of Pollution, (HMIP) focuses on petroleum processes such as oil refining and other associated processes. The various industrial processes used, their associated pollution release routes into the environment and techniques for controlling these releases are all discussed. Environmental quality standards are related to national and international agreements on pollution control and abatement. HMIP's work on air, water and land pollution monitoring is also reported. (UK)

Reflow process stabilization by chemical characteristics and process conditions

Science.gov (United States)

Kim, Myoung-Soo; Park, Jeong-Hyun; Kim, Hak-Joon; Kim, Il-Hyung; Jeon, Jae-Ha; Gil, Myung-Goon; Kim, Bong-Ho

2002-07-01

With the shrunken device rule below 130nm, the patterning of smaller contact hole with enough process margin is required for mass production. Therefore, shrinking technology using thermal reflow process has been applied for smaller contact hole formation. In this paper, we have investigated the effects of chemical characteristics such as molecular weight, blocking ratio of resin, cross-linker amount and solvent type with its composition to reflow process of resist and found the optimized chemical composition for reflow process applicable condition. And several process conditions like resist coating thickness and multi-step thermal reflow method have been also evaluated to stabilize the pattern profile and improve CD uniformity after reflow process. From the experiment results, it was confirmed that the effect of crosslinker in resist to reflow properties such as reflow temperature and reflow rate were very critical and it controlled the pattern profile during reflow processing. And also, it showed stable CD uniformity and improved resist properties for top loss, film shrinkage and etch selectivity. The application of lower coating thickness of resist induced symmetric pattern profile even at edge with wider process margin. The introduction of two-step baking method for reflow process showed uniform CD value, also. It is believed that the application of resist containing crosslinker and optimized process conditions for smaller contact hole patterning is necessary for the mass production with a design rule below 130nm.

Microcrystalline silicon deposition: Process stability and process control

International Nuclear Information System (INIS)

Donker, M.N. van den; Kilper, T.; Grunsky, D.; Rech, B.; Houben, L.; Kessels, W.M.M.; Sanden, M.C.M. van de

2007-01-01

Applying in situ process diagnostics, we identified several process drifts occurring in the parallel plate plasma deposition of microcrystalline silicon (μc-Si:H). These process drifts are powder formation (visible from diminishing dc-bias and changing spatial emission profile on a time scale of 10 0 s), transient SiH 4 depletion (visible from a decreasing SiH emission intensity on a time scale of 10 2 s), plasma heating (visible from an increasing substrate temperature on a time scale of 10 3 s) and a still puzzling long-term drift (visible from a decreasing SiH emission intensity on a time scale of 10 4 s). The effect of these drifts on the crystalline volume fraction in the deposited films is investigated by selected area electron diffraction and depth-profiled Raman spectroscopy. An example shows how the transient depletion and long-term drift can be prevented by suitable process control. Solar cells deposited using this process control show enhanced performance. Options for process control of plasma heating and powder formation are discussed

The permanent process

DEFF Research Database (Denmark)

Møller, Jesper; McCullagh, Peter

We extend the boson process first to a large class of Cox processes and second an even larger class of infinitely divisible point processes. Density and moment results are studied in detail. These results are obtained in closed form as weighted permanents, so the extension is called a permanent...... process. Temporal extensions and a particularly tractable case of the permanent process are also studied. Extensions of the ferminon process along similar lines, leading to so-called determinant processes, are discussed at the end. While the permanent process is attractive, the determinant process...

Multidimensional process discovery

NARCIS (Netherlands)

Ribeiro, J.T.S.

2013-01-01

Typically represented in event logs, business process data describe the execution of process events over time. Business process intelligence (BPI) techniques such as process mining can be applied to get strategic insight into business processes. Process discovery, conformance checking and

Process development

Energy Technology Data Exchange (ETDEWEB)

Schuegerl, K

1984-01-01

The item 'process development' comprises the production of acetonic/butonal with C. acetobylicum and the yeasting of potato waste. The target is to increase productivity by taking the following measures - optimation of media, on-line process analysis, analysis of reaction, mathematic modelling and identification of parameters, process simulation, development of a state estimator with the help of the on-line process analysis and the model, optimization and adaptive control.

Laplace transform in tracer kinetic modeling

Energy Technology Data Exchange (ETDEWEB)

Hauser, Eliete B., E-mail: eliete@pucrs.br [Instituto do Cerebro (InsCer/FAMAT/PUC-RS), Porto Alegre, RS, (Brazil). Faculdade de Matematica

2013-07-01

The main objective this paper is to quantify the pharmacokinetic processes: absorption, distribution and elimination of radiopharmaceutical(tracer), using Laplace transform method. When the drug is administered intravenously absorption is complete and is available in the bloodstream to be distributed throughout the whole body in all tissues and fluids, and to be eliminated. Mathematical modeling seeks to describe the processes of distribution and elimination through compartments, where distinct pools of tracer (spatial location or chemical state) are assigned to different compartments. A compartment model is described by a system of differential equations, where each equation represents the sum of all the transfer rates to and from a specific compartment. In this work a two-tissue irreversible compartment model is used for description of tracer, [{sup 18}F]2-fluor-2deoxy-D-glucose. In order to determine the parameters of the model, it is necessary to have information about the tracer delivery in the form of an input function representing the time-course of tracer concentration in arterial blood or plasma. We estimate the arterial input function in two stages and apply the Levenberg-Marquardt Method to solve nonlinear regressions. The transport of FDG across de arterial blood is very fast in the first ten minutes and then decreases slowly. We use de Heaviside function to represent this situation and this is the main contribution of this study. We apply the Laplace transform and the analytical solution for two-tissue irreversible compartment model is obtained. The only approach is to determinate de arterial input function. (author)

Statistical Process Control for KSC Processing

Science.gov (United States)

Ford, Roger G.; Delgado, Hector; Tilley, Randy

1996-01-01

The 1996 Summer Faculty Fellowship Program and Kennedy Space Center (KSC) served as the basis for a research effort into statistical process control for KSC processing. The effort entailed several tasks and goals. The first was to develop a customized statistical process control (SPC) course for the Safety and Mission Assurance Trends Analysis Group. The actual teaching of this course took place over several weeks. In addition, an Internet version of the same course complete with animation and video excerpts from the course when it was taught at KSC was developed. The application of SPC to shuttle processing took up the rest of the summer research project. This effort entailed the evaluation of SPC use at KSC, both present and potential, due to the change in roles for NASA and the Single Flight Operations Contractor (SFOC). Individual consulting on SPC use was accomplished as well as an evaluation of SPC software for KSC use in the future. A final accomplishment of the orientation of the author to NASA changes, terminology, data format, and new NASA task definitions will allow future consultation when the needs arise.

A method for manufacturing a tool part for an injection molding process, a hot embossing process, a nano-imprint process, or an extrusion process

DEFF Research Database (Denmark)

2013-01-01

The present invention relates to a method for manufacturing a tool part for an injection molding process, a hot embossing process, nano-imprint process or an extrusion process. First, there is provided a master structure (10) with a surface area comprising nanometre-sized protrusions (11...

Process control using modern systems of information processing

International Nuclear Information System (INIS)

Baldeweg, F.

1984-01-01

Modern digital automation techniques allow the application of demanding types of process control. These types of process control are characterized by their belonging to higher levels in a multilevel model. Functional and technical aspects of the performance of digital automation plants are presented and explained. A modern automation system is described considering special procedures of process control (e.g. real time diagnosis)

DUAL-PROCESS, a highly reliable process control system

International Nuclear Information System (INIS)

Buerger, L.; Gossanyi, A.; Parkanyi, T.; Szabo, G.; Vegh, E.

1983-02-01

A multiprocessor process control system is described. During its development the reliability was the most important aspect because it is used in the computerized control of a 5 MW research reactor. DUAL-PROCESS is fully compatible with the earlier single processor control system PROCESS-24K. The paper deals in detail with the communication, synchronization, error detection and error recovery problems of the operating system. (author)

Quasi-Birth-and-Death Processes with Rational Arrival Process Components

DEFF Research Database (Denmark)

Bean, Nigel G.; Nielsen, Bo Friis

2010-01-01

This paper introduces the concept of a Quasi-Birth-and-Death process (QBD) with Rational Arrival Process (RAP) components. We use the physical interpretation of the prediction process of the RAP, developed by Asmussen and Bladt, and develop an analysis that parallels the analysis of a traditional...... QBD. Further, we present an algorithm for the numerical evaluation of the matrix G. As an example, we consider two queues where the arrival process and the sequence of service times are taken from two dependent RAPs, that are not Markovian Arrival Processes......This paper introduces the concept of a Quasi-Birth-and-Death process (QBD) with Rational Arrival Process (RAP) components. We use the physical interpretation of the prediction process of the RAP, developed by Asmussen and Bladt, and develop an analysis that parallels the analysis of a traditional...

Stochastic processes

CERN Document Server

Parzen, Emanuel

1962-01-01

Well-written and accessible, this classic introduction to stochastic processes and related mathematics is appropriate for advanced undergraduate students of mathematics with a knowledge of calculus and continuous probability theory. The treatment offers examples of the wide variety of empirical phenomena for which stochastic processes provide mathematical models, and it develops the methods of probability model-building.Chapter 1 presents precise definitions of the notions of a random variable and a stochastic process and introduces the Wiener and Poisson processes. Subsequent chapters examine

Dosimetry and process control for radiation processing

International Nuclear Information System (INIS)

Mod Ali, N.

2002-01-01

Complete text of publication follows. Accurate radiation dosimetry can provide quality assurance in radiation processing. Considerable relevant experiences in dosimetry by the SSDL-MINT has necessitate the development of methods making measurement at gamma plant traceable to the national standard. It involves the establishment of proper calibration procedure and selection of appropriate transfer system/technique to assure adequate traceability to a primary radiation standard. The effort forms the basis for irradiation process control, the legal approval of the process by the public health authorities (medical product sterilization and food preservation) and the safety and acceptance of the product

Process mining using BPMN: relating event logs and process models

NARCIS (Netherlands)

Kalenkova, A.A.; van der Aalst, W.M.P.; Lomazova, I.A.; Rubin, V.A.

2017-01-01

Process-aware information systems (PAIS) are systems relying on processes, which involve human and software resources to achieve concrete goals. There is a need to develop approaches for modeling, analysis, improvement and monitoring processes within PAIS. These approaches include process mining

Process mining using BPMN : relating event logs and process models

NARCIS (Netherlands)

Kalenkova, A.A.; Aalst, van der W.M.P.; Lomazova, I.A.; Rubin, V.A.

2015-01-01

Process-aware information systems (PAIS) are systems relying on processes, which involve human and software resources to achieve concrete goals. There is a need to develop approaches for modeling, analysis, improvement and monitoring processes within PAIS. These approaches include process mining

Process modeling for Humanities: tracing and analyzing scientific processes

OpenAIRE

Hug , Charlotte; Salinesi , Camille; Deneckere , Rebecca; Lamasse , Stéphane

2011-01-01

International audience; This paper concerns epistemology and the understanding of research processes in Humanities, such as Archaeology. We believe that to properly understand research processes, it is essential to trace them. The collected traces depend on the process model established, which has to be as accurate as possible to exhaustively record the traces. In this paper, we briefly explain why the existing process models for Humanities are not sufficient to represent traces. We then pres...

Poisson processes

NARCIS (Netherlands)

Boxma, O.J.; Yechiali, U.; Ruggeri, F.; Kenett, R.S.; Faltin, F.W.

2007-01-01

The Poisson process is a stochastic counting process that arises naturally in a large variety of daily life situations. We present a few definitions of the Poisson process and discuss several properties as well as relations to some well-known probability distributions. We further briefly discuss the

Process improvement : the creation and evaluation of process alternatives

NARCIS (Netherlands)

Netjes, M.

2010-01-01

Companies continuously strive to improve their processes to increase productivity and delivered quality against lower costs. With Business Process Redesign (BPR) projects such improvement goals can be achieved. BPR involves the restructuring of business processes, stimulated by the application of

The permanental process

DEFF Research Database (Denmark)

McCullagh, Peter; Møller, Jesper

2006-01-01

We extend the boson process first to a large class of Cox processes and second to an even larger class of infinitely divisible point processes. Density and moment results are studied in detail. These results are obtained in closed form as weighted permanents, so the extension i called a permanental...... process. Temporal extensions and a particularly tractable case of the permanental process are also studied. Extensions of the fermion process along similar lines, leading to so-called determinantal processes, are discussed....

Dry process potentials

International Nuclear Information System (INIS)

Faugeras, P.

1997-01-01

Various dry processes have been studied and more or less developed in order particularly to reduce the waste quantities but none of them had replaced the PUREX process, for reasons departing to policy errors, un-appropriate demonstration examples or too late development, although realistic and efficient dry processes such as a fluoride selective volatility based processes have been demonstrated in France (CLOVIS, ATILA) and would be ten times cheaper than the PUREX process. Dry processes could regain interest in case of a nuclear revival (following global warming fears) or thermal wastes over-production. In the near future, dry processes could be introduced in complement to the PUREX process, especially at the end of the process cycle, for a more efficient recycling and safer storage (inactivation)

Business Process Customization using Process Merging Techniques

NARCIS (Netherlands)

Bulanov, Pavel; Lazovik, Alexander; Aiello, Marco

2012-01-01

One of the important application of service composition techniques lies in the field of business process management. Essentially a business process can be considered as a composition of services, which is usually prepared by domain experts, and many tasks still have to be performed manually. These

Origin and characterization of retrograde labeled neurons supplying the rat urethra using fiberoptic confocal fluorescent microscopy in vivo and immunohistochemistry.

Science.gov (United States)

Lee, Keon-Cheol; Sharma, Seema; Tuttle, Jeremy B; Steers, William D

2010-10-01

Autonomic innervation of urethral smooth muscle may influence urinary continence after prostatectomy. It is unclear whether the cavernous nerves carry fibers that influence continence. Using a retrograde axonal tracer combined with real-time in vivo imaging and ex vivo immunohistochemistry we determined the course and type of neurons supplying urethral smooth muscle distal to the prostate in the rat. We injected the retrograde axonal tracers cholera toxin B fragment-Alexa Fluor 488 and Fast Blue in the distal urethral smooth muscle in 10 rats each. Five days later the cavernous nerves and pelvic ganglion were imaged using fiberoptic confocal fluorescence microscopy (cholera toxin B fragment-Alexa Fluor 488) or harvested for immunohistochemistry (Fast Blue). Dual immunofluorescence of Fast Blue neurons with tyrosine hydroxylase or neuronal nitric oxide synthase was done to characterize neurons as noradrenergic or nitrergic. To ascertain whether the cavernous nerves contain fibers to the urethra that originate in the pelvic ganglia we cut the cavernous nerves with their ancillary branches in 3 rats and imaged them for Fast Blue. Fluorescent neurons and axons were detected in cavernous nerves and the pelvic ganglion. Few neurons were seen in rats with cavernous nerve section. Of urethral neurons 53.1% showed neuronal nitric oxide synthase positivity while 40.6% were immunoreactive for tyrosine hydroxylase. About 6.2% of urethral neurons failed to show tyrosine hydroxylase or neuronal nitric oxide synthase immunoreactivity. Most of the autonomic innervation to the urethra beyond the prostatic apex travels in the cavernous nerves. Many nerves may be parasympathetic based on neuronal nitric oxide synthase immunoreactivity. Nerves supplying the urethra outside the cavernous nerves may course posterior to the prostate. Along with afferent fibers, tyrosine hydroxylase immunoreactivity expressing neuron fibers, ie noradrenergic nerves, traveling in the cavernous nerves may

Role of ARF6 in internalization of metal-binding proteins, metallothionein and transferrin, and cadmium-metallothionein toxicity in kidney proximal tubule cells

International Nuclear Information System (INIS)

Wolff, Natascha A.; Lee, Wing-Kee; Abouhamed, Marouan; Thevenod, Frank

2008-01-01

Filtered metal-protein complexes, such as cadmium-metallothionein-1 (CdMT-1) or transferrin (Tf) are apically endocytosed partly via megalin/cubilin by kidney proximal tubule (PT) cells where CdMT-1 internalization causes apoptosis. Small GTPase ARF (ADP-ribosylation factor) proteins regulate endocytosis and vesicular trafficking. We investigated roles of ARF6, which has been shown to be involved in internalization of ligands and endocytic trafficking in PT cells, following MT-1/CdMT-1 and Tf uptake by PT cells. WKPT-0293 Cl.2 cells derived from rat PT S1 segment were transfected with hemagglutinin-tagged wild-type (ARF6-WT) or dominant negative (ARF6-T27N) forms of ARF6. Using immunofluorescence, endogenous ARF6 was associated with the plasma membrane (PM) as well as juxtanuclear and co-localized with Rab5a and Rab11 involved in early and recycling endosomal trafficking. Immunofluorescence staining of megalin showed reduced surface labelling in ARF6 dominant negative (ARF6-DN) cells. Intracellular Alexa Fluor 546-conjugated MT-1 uptake was reduced in ARF6-DN cells and CdMT-1 (14.8 μM for 24 h) toxicity was significantly attenuated from 27.3 ± 3.9% in ARF6-WT to 11.1 ± 4.0% in ARF6-DN cells (n = 6, P < 0.02). Moreover, reduced Alexa Fluor 546-conjugated Tf uptake was observed in ARF-DN cells (75.0 ± 4.6% versus 3.9 ± 3.9% of ARF6-WT cells, n = 3, P < 0.01) and/or remained near the PM (89.3 ± 5. 6% versus 45.2 ± 14.3% of ARF6-WT cells, n = 3, P < 0.05). In conclusion, the data support roles for ARF6 in receptor-mediated endocytosis and trafficking of MT-1/Tf to endosomes/lysosomes and CdMT-1 toxicity of PT cells

Evaluation of chemical fluorescent dyes as a protein conjugation partner for live cell imaging.

Directory of Open Access Journals (Sweden)

Yoko Hayashi-Takanaka

Full Text Available To optimize live cell fluorescence imaging, the choice of fluorescent substrate is a critical factor. Although genetically encoded fluorescent proteins have been used widely, chemical fluorescent dyes are still useful when conjugated to proteins or ligands. However, little information is available for the suitability of different fluorescent dyes for live imaging. We here systematically analyzed the property of a number of commercial fluorescent dyes when conjugated with antigen-binding (Fab fragments directed against specific histone modifications, in particular, phosphorylated H3S28 (H3S28ph and acetylated H3K9 (H3K9ac. These Fab fragments were conjugated with a fluorescent dye and loaded into living HeLa cells. H3S28ph-specific Fab fragments were expected to be enriched in condensed chromosomes, as H3S28 is phosphorylated during mitosis. However, the degree of Fab fragment enrichment on mitotic chromosomes varied depending on the conjugated dye. In general, green fluorescent dyes showed higher enrichment, compared to red and far-red fluorescent dyes, even when dye:protein conjugation ratios were similar. These differences are partly explained by an altered affinity of Fab fragment after dye-conjugation; some dyes have less effect on the affinity, while others can affect it more. Moreover, red and far-red fluorescent dyes tended to form aggregates in the cytoplasm. Similar results were observed when H3K9ac-specific Fab fragments were used, suggesting that the properties of each dye affect different Fab fragments similarly. According to our analysis, conjugation with green fluorescent dyes, like Alexa Fluor 488 and Dylight 488, has the least effect on Fab affinity and is the best for live cell imaging, although these dyes are less photostable than red fluorescent dyes. When multicolor imaging is required, we recommend the following dye combinations for optimal results: Alexa Fluor 488 (green, Cy3 (red, and Cy5 or CF640 (far-red.

[Influence of the fluoride releasing dental materials on the bacterial flora of dental plaque].

Science.gov (United States)

Płuciennik, Małgorzata; Sakowska, Danuta; Krzemiński, Zbigniew; Piatowska, Danuta

2008-01-01

The assessment of influence of silver-free, fluor releasing dental materials on dental plaque bacteria quantity. 17 patients were included into the study. 51 restorations were placed following manufacturers recommendations. Following materials were used: conventional glassionomer Ketac-Molar ESPE, resin modified glassionomer Fuji II LC GC and fluor containing composite Charisma Heraeus Kulzer Class V restorations were placed in following teeth of upper and lower jaw: canines, first bicuspids, second bicuspids. Sound enamel was a control. After 10 weeks the 72 hours old dental plaque was collected from surface of restorations and control using sterile probe. Total amount of 68 dental plaques were investigated. Each plaque was placed on scaled and sterile aluminum foil. The moist weight of dental plaque was scaled. Dental plaque was moved into 7 ml 0.85% NaCl solution reduced by cystein chlorine hydrogen and disintegrated by ultrasounds (power:100 Watt, wave amplitude: 5 micorm). The suspension of dental plaque was serially diluted from 10(-4) to 10(-5) in sterile 0,85% NaCl solution, and seeded with amount of 0.1 ml on appropriate base. In dental plaque trials the amount of cariogenic bacteria was calculated--Streptococcus mutans, Streptococcus, Lactobacillus, Veillonella and Neisseria, and also total amount of aerobic and anaerobic bacteria was measured. Microbiologic studies were performed in Institute of Microbiology, Medical University, Łódź. Statistical analysis of collected data was accomplished. In 72 hours old dental plaques collected from the surfaces of Ketac -Molar, Fuji II LC, Charisma after 10 weeks since being placed into the class V cavity, results show no statistically significant differences in the amount of Streptococcus mutans, Streptococcus spp., Lactobacillus spp., Veillonella spp., Neisseria spp, in total amount of aerobic and anaerobic bacteria and in the quantity proportion of Streptococcus mutans versus Streptococcus spp. in comparison

Urinary polycyclic aromatic hydrocarbon metabolites among 3-year-old children from Krakow, Poland.

Science.gov (United States)

Sochacka-Tatara, Elżbieta; Majewska, Renata; Perera, Frederica P; Camann, David; Spengler, John; Wheelock, Kylie; Sowa, Agata; Jacek, Ryszard; Mróz, Elżbieta; Pac, Agnieszka

2018-07-01

Polycyclic aromatic hydrocarbons (PAHs) are widespread in the environment and can adversely affect human health. The aim of the present study is to describe the level of PAHs exposure in children living in Kraków, one of the most polluted cities in Poland, and to determine the relationship of urinary biomarkers with environmental PAHsexposure. Urinary monohydroxy metabolites (OH-PAHs) of 20 PAHs were assessed in 218 three-year old children, of which only 10 were present in nearly all the samples: monohydroxy metabolites of naphthalene, fluorene, phenantrene and pyrene. Of the metabolites analyzed, hydroxynaphthalenes were predominant and constituted almost 73% of total excreted OH-PAHs, while 1-OH-PYRene was the least abundant (2.3% of total OH-PAHs). All measured urinary OH-PAHs were statistically significantly correlated with each other (R = 0.165-0.880) but the highest correlation coefficients with other individual OH-PAHs and with total OH-PAHs were observed for 2-OH-FLUOR. Children exposed at home to environmental tobacco smoke (ETS) had higher concentrations of fluorene and pyrene urinary metabolites compared to those without ETS exposure; and those exposed to gas-based appliances used for cooking or heating water had higher levels of fluorene and phenanthrene metabolites than children not exposed. The use of coal, wood or oil for heating was associated with elevated levels of 1-OH-PYRene. Urinary PAHs metabolites only modestly reflect high molecular weight carcinogenic PAHs exposures such as those monitored in air in the present study. None of the measured PAHs metabolites was correlated with airborne PM 2.5 and only two were slightly correlated with measured higher molecular mass airborne PAHs. The average concentrations of these specific metabolites in Polish children were much higher than observed in other pediatric populations living in developed countries. Our findings suggest that to capture various sources of PAHs, in addition to 1-OH

The deployment of an innovative real-time radiological soil characterization system

International Nuclear Information System (INIS)

Allen, David; Danahy, Raymond; Laird, Gregory; Seiller, Dale; White, Joan; Janke, Robert

2000-01-01

Fluor Fernald Inc., in conjunction with partners from Argonne National Laboratory, the Department of Energy's Environmental Measurements Laboratory, and Idaho National Engineering and Environmental Laboratory, has developed a program for characterizing radiological contaminants in soil in real time. The soil characterization system in use at the Fernald Environmental Management Project (FEMP) for over three years combines gamma ray spectrometry equipment with other technologies to produce a system that can scan large areas of ground and produce color coded maps which display quantitative information regarding isotopic contamination patterns. Software running on a battery powered lap-top computer, is used to control acquisition of gamma spectral data to link the spectral Information with precise detector position measurements from Global Positioning System (GPS) satellites, and to control transmission of data to a central station or van via a wireless Ethernet link where Surfer6 mapping software is used to produce maps showing the position and amount of each target analyte. Either sodium iodide (NaI) gamma ray detectors mounted on three different vehicles for mobile measurements or stationary tripod-mounted hyper-pure germanium (HPGe) detectors can be used in this system to radiologically characterize soil. The operational and performance characteristics, as well as the strengths and limitations of each of these units, will be described. The isotopic information generated by this system can be made available to remediation project mangers within an hour after the completion of a scan to aid in determination of excavation footprints, segregation of contaminated soil and verification of contamination removal. The immediate availability of radiological characterization data made possible by this real-time scanning system has allowed Fluor Fernald to accelerate remediation schedules and reduce costs by avoiding excavation delays and expensive and time consuming

Business process transformation the process tangram framework

CERN Document Server

Sharma, Chitra

2015-01-01

This book presents a framework through transformation and explains  how business goals can be translated into realistic plans that are tangible and yield real results in terms of the top line and the bottom line. Process Transformation is like a tangram puzzle, which has multiple solutions yet is essentially composed of seven 'tans' that hold it together. Based on practical experience and intensive research into existing material, 'Process Tangram' is a simple yet powerful framework that proposes Process Transformation as a program. The seven 'tans' are: the transformation program itself, triggers, goals, tools and techniques, culture, communication and success factors. With its segregation into tans and division into core elements, this framework makes it possible to use 'pick and choose' to quickly and easily map an organization's specific requirements. Change management and process modeling are covered in detail. In addition, the book approaches managed services as a model of service delivery, which it ex...

Composable Data Processing in Environmental Science - A Process View

NARCIS (Netherlands)

Wombacher, Andreas

Data processing in environmental science is essential for doing science. The heterogeneity of data sources, data processing operations and infrastructures results in a lot of manual data and process integration work done by each scientist individually. This is very inefficient and time consuming.

Processing module operating methods, processing modules, and communications systems

Science.gov (United States)

McCown, Steven Harvey; Derr, Kurt W.; Moore, Troy

2014-09-09

A processing module operating method includes using a processing module physically connected to a wireless communications device, requesting that the wireless communications device retrieve encrypted code from a web site and receiving the encrypted code from the wireless communications device. The wireless communications device is unable to decrypt the encrypted code. The method further includes using the processing module, decrypting the encrypted code, executing the decrypted code, and preventing the wireless communications device from accessing the decrypted code. Another processing module operating method includes using a processing module physically connected to a host device, executing an application within the processing module, allowing the application to exchange user interaction data communicated using a user interface of the host device with the host device, and allowing the application to use the host device as a communications device for exchanging information with a remote device distinct from the host device.

Improving the process of process modelling by the use of domain process patterns

NARCIS (Netherlands)

Koschmider, A.; Reijers, H.A.

2015-01-01

The use of business process models has become prevalent in a wide area of enterprise applications. But while their popularity is expanding, concerns are growing with respect to their proper creation and maintenance. An obvious way to boost the efficiency of creating high-quality business process

Trends in business process analysis: from verification to process mining

NARCIS (Netherlands)

Aalst, van der W.M.P.; Cardoso, J.; Cordeiro, J.; Filipe, J.

2007-01-01

Business process analysis ranges from model verification at design-time to the monitoring of processes at runtime. Much progress has been achieved in process verification. Today we are able to verify the entire reference model of SAP without any problems. Moreover, more and more processes leave

Automatic extraction of process categories from process model collections

NARCIS (Netherlands)

Malinova, M.; Dijkman, R.M.; Mendling, J.; Lohmann, N.; Song, M.; Wohed, P.

2014-01-01

Many organizations build up their business process management activities in an incremental way. As a result, there is no overarching structure defined at the beginning. However, as business process modeling initiatives often yield hundreds to thousands of process models, there is a growing need for

Opportunities and challenges for process control in process intensification

NARCIS (Netherlands)

Nikacevic, N.M.; Huesman, A.E.M.; Hof, Van den P.M.J.; Stankiewicz, A.

2012-01-01

This is a review and position article discussing the role and prospective for process control in process intensification. Firstly, the article outlines the classical role of control in process systems, presenting an overview of control systems’ development, from basic PID control to the advanced

Transforming spatial point processes into Poisson processes using random superposition

DEFF Research Database (Denmark)

Møller, Jesper; Berthelsen, Kasper Klitgaaard

with a complementary spatial point process Y  to obtain a Poisson process X∪Y  with intensity function β. Underlying this is a bivariate spatial birth-death process (Xt,Yt) which converges towards the distribution of (X,Y). We study the joint distribution of X and Y, and their marginal and conditional distributions....... In particular, we introduce a fast and easy simulation procedure for Y conditional on X. This may be used for model checking: given a model for the Papangelou intensity of the original spatial point process, this model is used to generate the complementary process, and the resulting superposition is a Poisson...... process with intensity function β if and only if the true Papangelou intensity is used. Whether the superposition is actually such a Poisson process can easily be examined using well known results and fast simulation procedures for Poisson processes. We illustrate this approach to model checking...

Process/Equipment Co-Simulation on Syngas Chemical Looping Process

Energy Technology Data Exchange (ETDEWEB)

Zeng, Liang; Zhou, Qiang; Fan, Liang-Shih

2012-09-30

The chemical looping strategy for fossil energy applications promises to achieve an efficient energy conversion system for electricity, liquid fuels, hydrogen and/or chemicals generation, while economically separate CO{sub 2} by looping reaction design in the process. Chemical looping particle performance, looping reactor engineering, and process design and applications are the key drivers to the success of chemical looping process development. In order to better understand and further scale up the chemical looping process, issues such as cost, time, measurement, safety, and other uncertainties need to be examined. To address these uncertainties, advanced reaction/reactor modeling and process simulation are highly desired and the modeling efforts can accelerate the chemical looping technology development, reduce the pilot-scale facility design time and operating campaigns, as well as reduce the cost and technical risks. The purpose of this work is thus to conduct multiscale modeling and simulations on the key aspects of chemical looping technology, including particle reaction kinetics, reactor design and operation, and process synthesis and optimization.

Process Fragment Libraries for Easier and Faster Development of Process-based Applications

Directory of Open Access Journals (Sweden)

David Schumm

2011-01-01

Full Text Available The term “process fragment” is recently gaining momentum in business process management research. We understand a process fragment as a connected and reusable process structure, which has relaxed completeness and consistency criteria compared to executable processes. We claim that process fragments allow for an easier and faster development of process-based applications. As evidence to this claim we present a process fragment concept and show a sample collection of concrete, real-world process fragments. We present advanced application scenarios for using such fragments in development of process-based applications. Process fragments are typically managed in a repository, forming a process fragment library. On top of a process fragment library from previous work, we discuss the potential impact of using process fragment libraries in cross-enterprise collaboration and application integration.

Rapid thermal processing and beyond applications in semiconductor processing

CERN Document Server

Lerch, W

2008-01-01

Heat-treatment and thermal annealing are very common processing steps which have been employed during semiconductor manufacturing right from the beginning of integrated circuit technology. In order to minimize undesired diffusion, and other thermal budget-dependent effects, the trend has been to reduce the annealing time sharply by switching from standard furnace batch-processing (involving several hours or even days), to rapid thermal processing involving soaking times of just a few seconds. This transition from thermal equilibrium, to highly non-equilibrium, processing was very challenging a

Fluorescence quantum yields of natural organic matter and organic compounds: Implications for the fluorescence-based interpretation of organic matter composition

DEFF Research Database (Denmark)

Wünsch, Urban; Murphy, Kathleen R.; Stedmon, Colin

2015-01-01

to more than 200 modeled spectra (PARAFAC components) in the OpenFluor database. Apparent matches, based on spectral similarity, were subsequently evaluated using molar fluorescence and absorbance. Five organic compounds were potential matches with PARAFAC components from 16 studies; however, the ability......Absorbance and fluorescence spectroscopy are economical tools for tracing the supply, turnover and fate of dissolved organic matter (DOM). The colored and fluorescent fractions of DOM (CDOM and FDOM, respectively) are linked by the apparent fluorescence quantum yield (AQY) of DOM, which reflects...... the likelihood that chromophores emit fluorescence after absorbing light. Compared to the number of studies investigating CDOM and FDOM, few studies have systematically investigated AQY spectra for DOM, and linked them to fluorescence quantum yields (Φ) of organic compounds. To offer a standardized approach...

Direct fluorescence detection of VirE2 secretion by Agrobacterium tumefaciens

Science.gov (United States)

Yaakov, Noga; Barak, Yoav; Pereman, Idan; Christie, Peter J.; Elbaum, Michael

2017-01-01

VirE2 is a ssDNA binding protein essential for virulence in Agrobacterium tumefaciens. A tetracysteine mutant (VirE2-TC) was prepared for in vitro and in vivo fluorescence imaging based on the ReAsH reagent. VirE2-TC was found to be biochemically active as it binds both ssDNA and the acidic secretion chaperone VirE1. It was also biologically functional in complementing virE2 null strains transforming Arabidopsis thaliana roots and Nicotiana tabacum leaves. In vitro experiments demonstrated a two-color fluorescent complex using VirE2-TC/ReAsH and Alexa Fluor 488 labeled ssDNA. In vivo, fluorescent VirE2-TC/ReAsH was detected in bacteria and in plant cells at time frames relevant to transformation. PMID:28403156

Computational study of cation substitutions in apatites

International Nuclear Information System (INIS)

Tamm, Toomas; Peld, Merike

2006-01-01

Density-functional theory plane-wave modeling of fluor- and hydroxyapatites has been performed, where one or two calcium ions per unit cell were replaced with cadmium or zinc cations. It was found that cadmium ions favor Ca(1) positions in fluorapatites and Ca(2) positions in hydroxyapatites, in agreement with experiment. A similar pattern is predicted for zinc substitutions. In the doubly substituted cases, where only hydroxyapatites were modeled, a preference for the substituting ions to be located in Ca(2) position was also observed. Displacement of the hydroxide ions from their symmetrical positions on the hexagonal axis can be used to explain the preferred configurations of substituting ions around the axis. -- Deformation of the hydroxide ion chain due to substitutions around the ion channel in substituted hydroxyapatites

Environmental Management Performance Report for December 1999

Energy Technology Data Exchange (ETDEWEB)

EDER, D.M.

2000-02-16

The purpose of the Environmental Management Performance Report (EMPR) is to provide the Department of Energy Richland Operations Office's (DOE-RL's) report of Hanford's Environmental Management (EM) performance by: U. S. Department of Energy, Richland Operations Office, Project Hanford Management Contract (PHMC) through Fluor Hanford, Inc. (FHI) and its subcontractors, Environmental Restoration Contract through Bechtel Hanford, Inc. (BHI), and its subcontractors, and Pacific Northwest National Laboratories (PNNL) for EM and EM Science and Technology (S&T) Mission. This report is a monthly publication that summarizes EM Site performance under RL Operations Office. It is organized by the four sections listed above, with each section containing an Executive Summary and Area Performance Summaries. A listing of what is contained in the sections can be found in the Table of Contents.

Plan for the Initiation of HA-211 Furnace Operations at the Plutonium Finishing Plan (PFP)

International Nuclear Information System (INIS)

WILLIS, H.T.

2000-01-01

This plan provides a phased approach authorizing the use of three additional muffle furnaces for thermal stabilization. Achievement of Thermal Stabilization mission elements require the installation and startup of three additional muffle furnaces for the thermal stabilization of plutonium and plutonium bearing materials at the Plutonium Finishing Plant (PFP). The release to operate these additional furnaces will require an Activity Based Startup Review. The conduct of the Activity Based Startup Review (ABSR) was approved by Fluor Daniel Hanford on October 15, 1999. This plan has been developed with the objective of identifying those activities needed to guide the controlled startup of five furnaces from authorization to unrestricted operations by adding the HA-211 furnaces in an orderly and safe manner after the approval to Startup has been given

Treatment of obesity: an update on anti-obesity medications.

Science.gov (United States)

Halpern, A; Mancini, M C

2003-02-01

The information presented in this article provides an overview of physiological agents, therapeutics in current use, and medications that have been extensively used in the past but are no longer available, or are not classically considered as anti-obesity drugs. The authors present an extensive review on the criteria for anti-obesity management efficacy, on physiological mechanisms that regulate central and/or peripheral action energetic homeostasis (nutrients, monoamines and peptides), and on beta-phenethylamine pharmacological-derivative agents (fenfluramine, dexfenfluramine, phentermine, diethylpropion, fenproporex and sibutramine), tricyclic derivatives (mazindol), phenylpropanolamine derivatives (ephedrine, phenylpropanolamine), a phenylpropanolamine oxy-tri-fluor-phenyl derivative (fluoxetine), a naftilamine derivative (sertraline) and a lipstatine derivative (orlistat). An analysis of all clinical trials longer than 10 weeks in duration is also presented for medications used in the management of obesity.

Bismuth- and lithium-loaded plastic scintillators for gamma and neutron detection

International Nuclear Information System (INIS)

Cherepy, Nerine J.; Sanner, Robert D.; Beck, Patrick R.; Swanberg, Erik L.; Tillotson, Thomas M.; Payne, Stephen A.; Hurlbut, Charles R.

2015-01-01

Transparent plastic scintillators based on polyvinyltoluene (PVT) have been fabricated with high loading of bismuth carboxylates for gamma spectroscopy, and with lithium carboxylates for neutron detection. When activated with a combination of standard fluors, 2,5-diphenyloxazole (PPO) and tetraphenylbutadiene (TPB), gamma light yields with 15 wt% bismuth tripivalate of 5000 Ph/MeV are measured. A PVT plastic formulation including 30 wt% lithium pivalate and 30 wt% PPO offers both pulse shape discrimination, and a neutron capture peak at ~400 keVee. In another configuration, a bismuth-loaded PVT plastic is coated with ZnS( 6 Li) paint, permitting simultaneous gamma and neutron detection via pulse shape discrimination with a figure-of-merit of 3.8, while offering gamma spectroscopy with energy resolution of R(662 keV)=15%

The Porgera gold deposit, Papua, New Guinea, 1: association with alkalic magmatism in a continent-island-arc collision zone

International Nuclear Information System (INIS)

Richards, J.P.; Chappell, B.W.; McCulloch, M.T.; McDougall, I.

1991-01-01

The meso thermal to epithermal Porgera gold deposit is spatially and temporally associated with shallow level (≤ 2 km emplacement depth) stocks and dykes of the Porgera Intrusive Complex (PIC). Gold mineralization immediately followed emplacement of the PIC, and is dated between 5 and 6 Ma ago. The Porgera intrusive suite is comprised of fine- to medium-grained, porphyritic to euhedral granular, volatile-rich, sodic alkali basalts/gabbros, hawaiites, and mugearites (TAS chemical classification scheme). The rocks display chemical and isotopic characteristics similar to those of intra plate alkalic basalts, but their unusually high volatile contents result in stabilization of hornblende as a phenocryst and intergranular phase in more evolved rock types. The observed order of cotectic crystallization is olivine - clinopyroxene - hornblende -plagioclase, with ubiquitous spinel (chromite/magnetite) and fluor-apatite. (author)

FFTF Authorization Agreement

International Nuclear Information System (INIS)

DAUTEL, W.A.

2000-01-01

The purpose of the Authorization Agreement is to serve as a mechanism whereby the U.S. Department of Energy, Richland Operations Office (RL) and Fluor Hanford (FH) jointly clarify and agree to key conditions for conducting work safely and efficiently in the Fast Flux Test Facility (FFTF). Work must be accomplished in a manner that achieves high levels of quality while protecting the environment and the safety and health of workers and the public, and complying with applicable contractual and regulatory requirements. It is the intent of this Agreement to address those items of significant importance in establishing and supporting the FFTF Authorization Envelope, but this Agreement in no way alters the terms and conditions of the Project Hanford Management Contract (PHMC), Contract Number DE-AC06-96RL13200

Environmental Management Performance Report November 2000

Energy Technology Data Exchange (ETDEWEB)

EDER, D.M.

2000-11-01

The purpose of the Environmental Management Performance Report (EMPR) is to provide the Department of Energy Richland Operations Office's (DOE-RL's) report of Hanford's Environmental Management (EM) performance by: Project Hanford Management Contract (PHMC) through Fluor Hanford, Inc. (FH) and its subcontractors; Environmental Restoration Contract through Bechtel Hanford, Inc. (BHI), and its subcontractors; Pacific Northwest National Laboratories (PNNL) for Science and Technology support to the EM Mission; and Office of Safety Regulation of the TWRS Privatization Contractor. This report is a monthly publication that summarizes EM Site performance under RL Operations Office. It is organized by the four sections listed above, with each section containing an Executive Summary and Area Performance Summaries. A glossary of terms is provided at the end of this report for reference purposes.

Fractional Processes and Fractional-Order Signal Processing Techniques and Applications

CERN Document Server

Sheng, Hu; Qiu, TianShuang

2012-01-01

Fractional processes are widely found in science, technology and engineering systems. In Fractional Processes and Fractional-order Signal Processing, some complex random signals, characterized by the presence of a heavy-tailed distribution or non-negligible dependence between distant observations (local and long memory), are introduced and examined from the ‘fractional’ perspective using simulation, fractional-order modeling and filtering and realization of fractional-order systems. These fractional-order signal processing (FOSP) techniques are based on fractional calculus, the fractional Fourier transform and fractional lower-order moments. Fractional Processes and Fractional-order Signal Processing: • presents fractional processes of fixed, variable and distributed order studied as the output of fractional-order differential systems; • introduces FOSP techniques and the fractional signals and fractional systems point of view; • details real-world-application examples of FOSP techniques to demonstr...

Clinical Processes - The Killer Application for Constraint-Based Process Interactions

DEFF Research Database (Denmark)

Jiménez-Ramírez, Andrés; Barba, Irene; Reichert, Manfred

2018-01-01

. The scenario is subject to complex temporal constraints and entails the need for coordinating the constraint-based interactions among the processes related to a patient treatment process. As demonstrated in this work, the selected real process scenario can be suitably modeled through a declarative approach....... examples. However, to the best of our knowledge, they have not been used to model complex, real-world scenarios that comprise constraints going beyond control-flow. In this paper, we propose the use of a declarative language for modeling a sophisticated healthcare process scenario from the real world......For more than a decade, the interest in aligning information systems in a process-oriented way has been increasing. To enable operational support for business processes, the latter are usually specified in an imperative way. The resulting process models, however, tend to be too rigid to meet...

Process innovation laboratory

DEFF Research Database (Denmark)

Møller, Charles

2007-01-01

to create a new methodology for developing and exploring process models and applications. The paper outlines the process innovation laboratory as a new approach to BPI. The process innovation laboratory is a comprehensive framework and a collaborative workspace for experimenting with process models....... The process innovation laboratory facilitates innovation by using an integrated action learning approach to process modelling in a controlled environment. The study is based on design science and the paper also discusses the implications to EIS research and practice......Most organizations today are required not only to operate effective business processes but also to allow for changing business conditions at an increasing rate. Today nearly every business relies on their enterprise information systems (EIS) for process integration and future generations of EIS...

[Influence of dental caries prophylaxis using fluor-vigantoletten 1000 on plasma fluoride levels in infants (author's transl)].

Science.gov (United States)

Fuchs, C; Pohlandt, F; Abigt, J; Töllner, U; Heimann, G

1979-04-01

A group of 57 newborns was divided into two: group I (27 subjects) received solely 1,000 I.U. vitamin D3 per day for 6 months, whereas group II (30 subjects) were given a combination of 1,000 I.U. vitamin D3 and 0.25 mg fluoride. At the end of the time of observation there was a significant difference between the plasma concentrations in the two groups. The median value was 13.06 microgram/l (range: 8:18-39.4 microgram/l) in group I and 16.54 microgram/l (range: 9.9--41.2 microgram/l) in group II. Fluoride is obviously available to infants when administered in combination with Vitamin D3. In addition, it could be proven, that after 6 month administration of fluoride there are no signs of cumulation, overdosage or even intoxication.

Membrane processes

Science.gov (United States)

Staszak, Katarzyna

2017-11-01

The membrane processes have played important role in the industrial separation process. These technologies can be found in all industrial areas such as food, beverages, metallurgy, pulp and paper, textile, pharmaceutical, automotive, biotechnology and chemical industry, as well as in water treatment for domestic and industrial application. Although these processes are known since twentieth century, there are still many studies that focus on the testing of new membranes' materials and determining of conditions for optimal selectivity, i. e. the optimum transmembrane pressure (TMP) or permeate flux to minimize fouling. Moreover the researchers proposed some calculation methods to predict the membrane processes properties. In this article, the laboratory scale experiments of membrane separation techniques, as well their validation by calculation methods are presented. Because membrane is the "heart" of the process, experimental and computational methods for its characterization are also described.

PROPOSAL OF SPATIAL OPTIMIZATION OF PRODUCTION PROCESS IN PROCESS DESIGNER

Directory of Open Access Journals (Sweden)

Peter Malega

2015-03-01

Full Text Available This contribution is focused on optimizing the use of space in the production process using software Process Designer. The aim of this contribution is to suggest possible improvements to the existing layout of the selected production process. Production process was analysed in terms of inputs, outputs and course of actions. Nowadays there are many software solutions aimed at optimizing the use of space. One of these software products is the Process Designer, which belongs to the product line Tecnomatix. This software is primarily aimed at production planning. With Process Designer is possible to design the layout of production and subsequently to analyse the production or to change according to the current needs of the company.

Process automation

International Nuclear Information System (INIS)

Moser, D.R.

1986-01-01

Process automation technology has been pursued in the chemical processing industries and to a very limited extent in nuclear fuel reprocessing. Its effective use has been restricted in the past by the lack of diverse and reliable process instrumentation and the unavailability of sophisticated software designed for process control. The Integrated Equipment Test (IET) facility was developed by the Consolidated Fuel Reprocessing Program (CFRP) in part to demonstrate new concepts for control of advanced nuclear fuel reprocessing plants. A demonstration of fuel reprocessing equipment automation using advanced instrumentation and a modern, microprocessor-based control system is nearing completion in the facility. This facility provides for the synergistic testing of all chemical process features of a prototypical fuel reprocessing plant that can be attained with unirradiated uranium-bearing feed materials. The unique equipment and mission of the IET facility make it an ideal test bed for automation studies. This effort will provide for the demonstration of the plant automation concept and for the development of techniques for similar applications in a full-scale plant. A set of preliminary recommendations for implementing process automation has been compiled. Some of these concepts are not generally recognized or accepted. The automation work now under way in the IET facility should be useful to others in helping avoid costly mistakes because of the underutilization or misapplication of process automation. 6 figs

Process Analytical Technology (PAT): batch-to-batch reproducibility of fermentation processes by robust process operational design and control.

Science.gov (United States)

Gnoth, S; Jenzsch, M; Simutis, R; Lübbert, A

2007-10-31

The Process Analytical Technology (PAT) initiative of the FDA is a reaction on the increasing discrepancy between current possibilities in process supervision and control of pharmaceutical production processes and its current application in industrial manufacturing processes. With rigid approval practices based on standard operational procedures, adaptations of production reactors towards the state of the art were more or less inhibited for long years. Now PAT paves the way for continuous process and product improvements through improved process supervision based on knowledge-based data analysis, "Quality-by-Design"-concepts, and, finally, through feedback control. Examples of up-to-date implementations of this concept are presented. They are taken from one key group of processes in recombinant pharmaceutical protein manufacturing, the cultivations of genetically modified Escherichia coli bacteria.

Integration of Formal Job Hazard Analysis and ALARA Work Practice

International Nuclear Information System (INIS)

NELSEN, D.P.

2002-01-01

ALARA work practices have traditionally centered on reducing radiological exposure and controlling contamination. As such, ALARA policies and procedures are not well suited to a wide range of chemical and human health issues. Assessing relative risk, identifying appropriate engineering/administrative controls and selecting proper Personal Protective Equipment (PPE) for non nuclear work activities extends beyond the limitations of traditional ALARA programs. Forging a comprehensive safety management program in today's (2002) work environment requires a disciplined dialog between health and safety professionals (e.g. safety, engineering, environmental, quality assurance, industrial hygiene, ALARA, etc.) and personnel working in the field. Integrating organizational priorities, maintaining effective pre-planning of work and supporting a team-based approach to safety management represents today's hallmark of safety excellence. Relying on the mandates of any single safety program does not provide industrial hygiene with the tools necessary to implement an integrated safety program. The establishment of tools and processes capable of sustaining a comprehensive safety program represents a key responsibility of industrial hygiene. Fluor Hanford has built integrated safety management around three programmatic attributes: (1) Integration of radiological, chemical and ergonomic issues under a single program. (2) Continuous improvement in routine communications among work planning/scheduling, job execution and management. (3) Rapid response to changing work conditions, formalized work planning and integrated worker involvement

TCLP Preparation and Analysis of K East Basin Composite Sludge Samples

International Nuclear Information System (INIS)

Silvers, K.L.; Wagner, J.J.; Steele, R.T.

2000-01-01

Sludge samples from the Hanford K East Basin were analyzed by the Toxicity Characterization Leaching Procedure (TCLP) to assist in the appropriate Resource Conservation and Recovery Act (RCIL4) designation of this material. Sludge samples were collected by Fluor Hanford, Inc. using the consolidated sludge sampling system (system that allows collection of a single sample from multiple sample locations). These samples were shipped to the Postirradiation Testing Laboratory (PTL, 327 Building) and then transferred to the Pacific Northwest National Laboratory (PNNL) Radiochemical Processing Laboratory (RPL, 325 Building) for recovery and testing. Two sludge composites were prepared, using the consolidated sludge samples, to represent K East canister sludge (sample KC Can Comp) and K East floor sludge (sample KC Floor Comp). Each composite was extracted in duplicate and analyzed in duplicate following pre-approved(a) TCLP extraction and analyses procedures. In addition, these samples and duplicates were analyzed for total RCRA metals (via acid digestion preparation). The work was conducted in accordance with the requirements of the Hanford Analytical Quality Assurance Requirements Document (HASQARD). A PNNL Quality Assurance Program compliant with J HASQARD was implemented for this effort. The results from the TCLP analyses showed that all RCRA metal concentrations were less than the TCLP limits for both the canister and floor composite samples and their respective duplicates

WASTE TREATMENT PLANT (WTP) LIQUID EFFLUENT TREATABILITY EVALUATION

International Nuclear Information System (INIS)

LUECK, K.J.

2004-01-01

A forecast of the radioactive, dangerous liquid effluents expected to be produced by the Waste Treatment Plant (WTP) was provided by Bechtel National, Inc. (BNI 2004). The forecast represents the liquid effluents generated from the processing of Tank Farm waste through the end-of-mission for the WTP. The WTP forecast is provided in the Appendices. The WTP liquid effluents will be stored, treated, and disposed of in the Liquid Effluent Retention Facility (LERF) and the Effluent Treatment Facility (ETF). Both facilities are located in the 200 East Area and are operated by Fluor Hanford, Inc. (FH) for the US. Department of Energy (DOE). The treatability of the WTP liquid effluents in the LERF/ETF was evaluated. The evaluation was conducted by comparing the forecast to the LERF/ETF treatability envelope (Aromi 1997), which provides information on the items which determine if a liquid effluent is acceptable for receipt and treatment at the LERF/ETF. The format of the evaluation corresponds directly to the outline of the treatability envelope document. Except where noted, the maximum annual average concentrations over the range of the 27 year forecast was evaluated against the treatability envelope. This is an acceptable approach because the volume capacity in the LERF Basin will equalize the minimum and maximum peaks. Background information on the LERF/ETF design basis is provided in the treatability envelope document

Progress report on decommissioning activities at the Fernald Environmental Management Project (FEMP) site

International Nuclear Information System (INIS)

1998-01-01

The Fernald Environmental Management Project (FEMP), is located about 18 miles northwest of Cincinnati, Ohio. Between 1953 and 1989, the facility, then called the Feed Material Production Center or FMPC, produced uranium metal products used in the eventual production of weapons grade material for use by other US Department of Energy (DOE) sites. In 1989, FMPC's production was suspended by the federal government in order to focus resources on environmental restoration versus defense production. In 1992, Fluor Daniel Fernald assumed responsibility for managing all cleanup activities at the FEMP under contract to the DOE. In 1990, as part of the remediation effort, the site was divided into five operable units based on physical proximity of contaminated areas, similar amounts of types of contamination, or the potential for a similar technology to be used in cleanup activities. This report continues the outline of the decontamination and decommissioning (D and D) activities at the FEMP site Operable Unit 3 (OU3) and provides an update on the status of the decommissioning activities. OU3, the Facilities Closure and Demolition Project, involves the remediation of more than 200 uranium processing facilities. The mission of the project is to remove nuclear materials stored in these buildings, then perform the clean out of the buildings and equipment, and decontaminate and dismantle the facilities

Defense Waste Processing Facility Process Simulation Package Life Cycle

International Nuclear Information System (INIS)

Reuter, K.

1991-01-01

The Defense Waste Processing Facility (DWPF) will be used to immobilize high level liquid radioactive waste into safe, stable, and manageable solid form. The complexity and classification of the facility requires that a performance based operator training to satisfy Department of Energy orders and guidelines. A major portion of the training program will be the application and utilization of Process Simulation Packages to assist in training the Control Room Operators on the fluctionality of the process and the application of the Distribution Control System (DCS) in operating and managing the DWPF process. The packages are being developed by the DWPF Computer and Information Systems Simulation Group. This paper will describe the DWPF Process Simulation Package Life Cycle. The areas of package scope, development, validation, and configuration management will be reviewed and discussed in detail

Comparative process mining in education : an approach based on process cubes

NARCIS (Netherlands)

van der Aalst, W.M.P.; Guo, S.; Gorissen, P.J.B.; Ceravolo, P.; Accorsi, R.; Cudre-Mauroux, P.

2015-01-01

Process mining techniques enable the analysis of a wide variety of processes using event data. For example, event logs can be used to automatically learn a process model (e.g., a Petri net or BPMN model). Next to the automated discovery of the real underlying process, there are process mining

Outsourcing of training

International Nuclear Information System (INIS)

Gamin, Jim

2003-01-01

In 1996, Flour Daniel Hanford, Inc. along with several other partners were awarded the Project Hanford Management Contract (PHMC). The contract for Management and Integration (M and I) differed significantly from previous contracts awarded at the Hanford site. As the lead contractor, FHD was expected to help diversify the area economy by outsourcing upwards of 50% f the work previously performed by contractor staff, with outsourcing reference to local business. In addition to creating private sector jobs, FDH was expected to infuse 'best commercial practices' into the Hanford clean-up effort, thus achieving greater results within the available funding levels approved by the U.S. Congress. In 1997, FDH Training began the process of outsourcing site-wide training. The process took nearly a year from start to contract award and included the delivery and maintenance of over 100 nuclear and non-nuclear worker training courses. In March of 1998, Fluor Daniel Hanford outsourced a large segment of the general training required for Department of Energy nuclear and non-nuclear workers at Hanford. The segment of training that was outsourced impacts the safety and operations of the different Hanford Site facilities managed by seven major subcontractors who make up the Project Hanford Management Companies (PHMC). This work was outsourced to Exitech Columbia Corporation in a competitive bid process. The three major types of training outsourced were: Hazardous Materials Health and Safety; General Industry Health and Safety; Technical Development and Quality. During the first 16 months of this outsourcing effort we have learned several important lessons that I would like to take a few minutes and share with you. I believe that these lessons learned will be applicable to virtually every outsourcing effort undertaken by a training organization

Indexing contamination surveys

International Nuclear Information System (INIS)

Brown, R.L.

1998-01-01

The responsibility for safely managing the Tank Farms at Hanford belongs to Lockheed Martin Hanford Corporation which is part of the six company Project Hanford Management Team led by Fluor Daniel Hanford, Inc.. These Tank Farm Facilities contain numerous outdoor contamination areas which are surveyed at a periodicity consistent with the potential radiological conditions, occupancy, and risk of changes in radiological conditions. This document describes the survey documentation and data tracking method devised to track the results of contamination surveys this process is referred to as indexing. The indexing process takes a representative data set as an indicator for the contamination status of the facility. The data are further manipulated into a single value that can be tracked and trended using standard statistical methodology. To report meaningful data, the routine contamination surveys must be performed in a manner that allows the survey method and the data collection process to be recreated. Three key criteria are necessary to accomplish this goal: Accurate maps, consistent documentation, and consistent consolidation of data meeting these criteria provides data of sufficient quality to be tracked. Tracking of survey data is accomplished by converting the individual survey results into a weighted value, corrected for the actual number of survey points. This information can be compared over time using standard statistical analysis to identify trends. At the Tank Farms, the need to track and trend the facility's radiological status presents unique challenges. Many of these Tank Farm facilities date back to the second world war. The Tank Farm Facilities are exposed to weather extremes, plant and animal intrusion, as well as all of the normal challenges associated with handling radiological waste streams. Routine radiological surveys did not provide a radiological status adequate for continuing comparisons

Lake Charles CCS Project

Energy Technology Data Exchange (ETDEWEB)

Leib, Thomas [Leucadia Energy, LLC, Salt Lake City, UT (United States); Cole, Dan [Denbury Onshore, LLC, Plano, TX (United States)

2015-06-30

, construction labor, engineering, and other costs. The CCS Project Final Technical Report is based on a Front End Engineering and Design (FEED) study prepared by SK E&C, completed in [June] 2014. Subsequently, Fluor Enterprises completed a FEED validation study in mid-September 2014. The design analyses indicated that the FEED package was sufficient and as expected. However, Fluor considered the construction risk based on a stick-build approach to be unacceptable, but construction risk would be substantially mitigated through utilization of modular construction where site labor and schedule uncertainty is minimized. Fluor’s estimate of the overall EPC project cost utilizing the revised construction plan was comparable to SKE&C’s value after reflecting Fluor’s assessment of project scope and risk characteristic. Development was halted upon conclusion of Phase 2A FEED and the project was not constructed.Transport and Sequestration – The overall objective of the pipeline project was to construct a pipeline to transport captured CO₂ from the Lake Charles Clean Energy project to the existing Denbury Green Line and then to the Hastings Field in Southeast Texas to demonstrate effective geologic sequestration of captured CO₂ through commercial EOR operations. The overall objective of the MVA portion of the project was to demonstrate effective geologic sequestration of captured CO₂ through commercial Enhanced Oil Recovery (EOR) operations in order to evaluate costs, operational processes and technical performance. The DOE target for the project was to capture and implement a research MVA program to demonstrate the sequestration through EOR of approximately one million tons of CO₂ per year as an integral component of commercial operations.

Process mining

DEFF Research Database (Denmark)

van der Aalst, W.M.P.; Rubin, V.; Verbeek, H.M.W.

2010-01-01

Process mining includes the automated discovery of processes from event logs. Based on observed events (e.g., activities being executed or messages being exchanged) a process model is constructed. One of the essential problems in process mining is that one cannot assume to have seen all possible...... behavior. At best, one has seen a representative subset. Therefore, classical synthesis techniques are not suitable as they aim at finding a model that is able to exactly reproduce the log. Existing process mining techniques try to avoid such “overfitting” by generalizing the model to allow for more...... support for it). None of the existing techniques enables the user to control the balance between “overfitting” and “underfitting”. To address this, we propose a two-step approach. First, using a configurable approach, a transition system is constructed. Then, using the “theory of regions”, the model...