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Sample records for fluid system mechanotransduction

  1. Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation

    Directory of Open Access Journals (Sweden)

    Fung Peter

    2009-05-01

    Full Text Available Abstract This article hypothesizes that the Chinese medicine meridian system is a special channel network comprising of skin with abundant nerves and nociceptive receptors of various types, and deeper connective tissues inside the body with the flowing interstitial fluid system. These meridian channels provide efficient migratory tracks mainly due to durotaxis (also including chemotaxis for mast cells, fibroblasts and other cells to migrate and carry out a number of physiological functions. Acupuncture acting on meridian channel causes cytoskeletal remodeling through mechanotransduction, leading to regulation of gene expression and the subsequent production of related proteins. Also, stimulation on cell surface can trigger Ca2+ activities, resulting in a cascade of intra- and inter-cellular signaling. Moreover, nerve endings in the meridian channels interact with mast cells and induce the degranulation of these cells, leading to the release of many specific biomolecules needed for homeostasis, immune surveillance, wound healing and tissue repair. Acupoint along a meridian channel is a functional site to trigger the above functions with specificity and high efficiency.

  2. Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia

    Science.gov (United States)

    Baeyens, Nicolas; Larrivée, Bruno; Ola, Roxana; Hayward-Piatkowskyi, Brielle; Dubrac, Alexandre; Huang, Billy; Ross, Tyler D.; Coon, Brian G.; Min, Elizabeth; Tsarfati, Maya; Tong, Haibin; Eichmann, Anne

    2016-01-01

    Morphogenesis of the vascular system is strongly modulated by mechanical forces from blood flow. Hereditary hemorrhagic telangiectasia (HHT) is an inherited autosomal-dominant disease in which arteriovenous malformations and telangiectasias accumulate with age. Most cases are linked to heterozygous mutations in Alk1 or Endoglin, receptors for bone morphogenetic proteins (BMPs) 9 and 10. Evidence suggests that a second hit results in clonal expansion of endothelial cells to form lesions with poor mural cell coverage that spontaneously rupture and bleed. We now report that fluid shear stress potentiates BMPs to activate Alk1 signaling, which correlates with enhanced association of Alk1 and endoglin. Alk1 is required for BMP9 and flow responses, whereas endoglin is only required for enhancement by flow. This pathway mediates both inhibition of endothelial proliferation and recruitment of mural cells; thus, its loss blocks flow-induced vascular stabilization. Identification of Alk1 signaling as a convergence point for flow and soluble ligands provides a molecular mechanism for development of HHT lesions. PMID:27646277

  3. Lung heparan sulfates modulate Kfc during increased vascular pressure: evidence for glycocalyx-mediated mechanotransduction

    Science.gov (United States)

    Cluff, Mark; Kingston, Joseph; Hill, Denzil; Chen, Haiyan; Hoehne, Soeren; Malleske, Daniel T.; Kaur, Rajwinederjit

    2012-01-01

    Lung endothelial cells respond to changes in vascular pressure through mechanotransduction pathways that alter barrier function via non-Starling mechanism(s). Components of the endothelial glycocalyx have been shown to participate in mechanotransduction in vitro and in systemic vessels, but the glycocalyx's role in mechanosensing and pulmonary barrier function has not been characterized. Mechanotransduction pathways may represent novel targets for therapeutic intervention during states of elevated pulmonary pressure such as acute heart failure, fluid overload, and mechanical ventilation. Our objective was to assess the effects of increasing vascular pressure on whole lung filtration coefficient (Kfc) and characterize the role of endothelial heparan sulfates in mediating mechanotransduction and associated increases in Kfc. Isolated perfused rat lung preparation was used to measure Kfc in response to changes in vascular pressure in combination with superimposed changes in airway pressure. The roles of heparan sulfates, nitric oxide, and reactive oxygen species were investigated. Increases in capillary pressure altered Kfc in a nonlinear relationship, suggesting non-Starling mechanism(s). nitro-l-arginine methyl ester and heparanase III attenuated the effects of increased capillary pressure on Kfc, demonstrating active mechanotransduction leading to barrier dysfunction. The nitric oxide (NO) donor S-nitrosoglutathione exacerbated pressure-mediated increase in Kfc. Ventilation strategies altered lung NO concentration and the Kfc response to increases in vascular pressure. This is the first study to demonstrate a role for the glycocalyx in whole lung mechanotransduction and has important implications in understanding the regulation of vascular permeability in the context of vascular pressure, fluid status, and ventilation strategies. PMID:22160307

  4. Biomaterials and bone mechanotransduction

    Science.gov (United States)

    Sikavitsas, V. I.; Temenoff, J. S.; Mikos, A. G.; McIntire, L. V. (Principal Investigator)

    2001-01-01

    Bone is an extremely complex tissue that provides many essential functions in the body. Bone tissue engineering holds great promise in providing strategies that will result in complete regeneration of bone and restoration of its function. Currently, such strategies include the transplantation of highly porous scaffolds seeded with cells. Prior to transplantation the seeded cells are cultured in vitro in order for the cells to proliferate, differentiate and generate extracellular matrix. Factors that can affect cellular function include the cell-biomaterial interaction, as well as the biochemical and the mechanical environment. To optimize culture conditions, good understanding of these parameters is necessary. The new developments in bone biology, bone cell mechanotransduction, and cell-surface interactions are reviewed here to demonstrate that bone mechanotransduction is strongly influenced by the biomaterial properties.

  5. Force-induced bone growth and adaptation: A system theoretical approach to understanding bone mechanotransduction

    International Nuclear Information System (INIS)

    Maldonado, Solvey; Findeisen, Rolf

    2010-01-01

    The modeling, analysis, and design of treatment therapies for bone disorders based on the paradigm of force-induced bone growth and adaptation is a challenging task. Mathematical models provide, in comparison to clinical, medical and biological approaches an structured alternative framework to understand the concurrent effects of the multiple factors involved in bone remodeling. By now, there are few mathematical models describing the appearing complex interactions. However, the resulting models are complex and difficult to analyze, due to the strong nonlinearities appearing in the equations, the wide range of variability of the states, and the uncertainties in parameters. In this work, we focus on analyzing the effects of changes in model structure and parameters/inputs variations on the overall steady state behavior using systems theoretical methods. Based on an briefly reviewed existing model that describes force-induced bone adaptation, the main objective of this work is to analyze the stationary behavior and to identify plausible treatment targets for remodeling related bone disorders. Identifying plausible targets can help in the development of optimal treatments combining both physical activity and drug-medication. Such treatments help to improve/maintain/restore bone strength, which deteriorates under bone disorder conditions, such as estrogen deficiency.

  6. Adding dimension to cellular mechanotransduction: Advances in biomedical engineering of multiaxial cell-stretch systems and their application to cardiovascular biomechanics and mechano-signaling.

    Science.gov (United States)

    Friedrich, O; Schneidereit, D; Nikolaev, Y A; Nikolova-Krstevski, V; Schürmann, S; Wirth-Hücking, A; Merten, A L; Fatkin, D; Martinac, B

    2017-11-01

    Hollow organs (e.g. heart) experience pressure-induced mechanical wall stress sensed by molecular mechano-biosensors, including mechanosensitive ion channels, to translate into intracellular signaling. For direct mechanistic studies, stretch devices to apply defined extensions to cells adhered to elastomeric membranes have stimulated mechanotransduction research. However, most engineered systems only exploit unilateral cellular stretch. In addition, it is often taken for granted that stretch applied by hardware translates 1:1 to the cell membrane. However, the latter crucially depends on the tightness of the cell-substrate junction by focal adhesion complexes and is often not calibrated for. In the heart, (increased) hemodynamic volume/pressure load is associated with (increased) multiaxial wall tension, stretching individual cardiomyocytes in multiple directions. To adequately study cellular models of chronic organ distension on a cellular level, biomedical engineering faces challenges to implement multiaxial cell stretch systems that allow observing cell reactions to stretch during live-cell imaging, and to calibrate for hardware-to-cell membrane stretch translation. Here, we review mechanotransduction, cell stretch technologies from uni-to multiaxial designs in cardio-vascular research, and the importance of the stretch substrate-cell membrane junction. We also present new results using our IsoStretcher to demonstrate mechanosensitivity of Piezo1 in HEK293 cells and stretch-induced Ca 2+ entry in 3D-hydrogel-embedded cardiomyocytes. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Process fluid cooling system

    International Nuclear Information System (INIS)

    Farquhar, N.G.; Schwab, J.A.

    1977-01-01

    A system of heat exchangers is disclosed for cooling process fluids. The system is particularly applicable to cooling steam generator blowdown fluid in a nuclear plant prior to chemical purification of the fluid in which it minimizes the potential of boiling of the plant cooling water which cools the blowdown fluid

  8. Mechanotransduction through Cytoskeleton

    Science.gov (United States)

    Ingber, Donald

    2002-01-01

    The goal of this project was to characterize the molecular mechanism by which cells recognize and respond to physical forces in their local environment. The project was based on the working hypothesis that cells sense mechanical stresses, such as those due to gravity, through their cell surface adhesion receptors (e.g., integrins) and that they respond as a result of structural arrangements with their internal cytoskeleton (CSK) which are orchestrated through use of tensegrity architecture. In this project, we carried out studies to define the architectural and molecular basis of cellular mechanotransduction. Our major goal was to define the molecular pathway that mediates mechanical force transfer between integrins and the CSK and to determine how mechanical deformation of integrin-CSK linkages is transduced into a biochemical response. Elucidation of the mechanism by which cells sense mechanical stresses through integrins and translate them into a biochemical response should help us to understand the molecular basis of the cellular response to gravity as well as many other forms of mechanosensation and tissue regulation. The specific aims of this proposal were: 1. To define the molecular basis of mechanical coupling between integrins, vinculin, and the actin CSK; 2. To develop a computer simulation of how mechanical stresses alter CSK structure and test this model in living cells; 3. To determine how mechanical deformation of integrin-CSK linkages is transduced into a biochemical response.

  9. Mechanotransduction mechanisms in growing spherically structured tissues

    Science.gov (United States)

    Littlejohns, Euan; Dunlop, Carina M.

    2018-04-01

    There is increasing experimental interest in mechanotransduction in multi-cellular tissues as opposed to single cells. This is driven by a growing awareness of the importance of physiologically relevant three-dimensional culture and of cell–cell and cell–gel interactions in directing growth and development. The paradigm biophysical technique for investigating tissue level mechanobiology in this context is to grow model tissues in artificial gels with well-defined mechanical properties. These studies often indicate that the stiffness of the encapsulating gel can significantly alter cellular behaviours. We demonstrate here potential mechanisms linking tissue growth with stiffness-mediated mechanotransduction. We show how tissue growth in gel systems generates points at which there is a significant qualitative change in the cellular stress and strain experienced. We show analytically how these potential switching points depend on the mechanical properties of the constraining gel and predict when they will occur. Significantly, we identify distinct mechanisms that act separately in each of the stress and strain fields at different times. These observations suggest growth as a potential physical mechanism coupling gel stiffness with cellular mechanotransduction in three-dimensional tissues. We additionally show that non-proliferating areas, in the case that the constraining gel is soft compared with the tissue, will expand and contract passively as a result of growth. Central compartment size is thus seen to not be a reliable indicator on its own for growth initiation or active behaviour.

  10. Fluid flow control system

    International Nuclear Information System (INIS)

    Rion, Jacky.

    1982-01-01

    Fluid flow control system featuring a series of grids placed perpendicular to the fluid flow direction, characterized by the fact that it is formed of a stack of identical and continuous grids, each of which consists of identical meshes forming a flat lattice. The said meshes are offset from one grid to the next. This system applies in particular to flow control of the coolant flowing at the foot of an assembly of a liquid metal cooled nuclear reactor [fr

  11. Mechanotransduction and the Cytoskeleton

    Science.gov (United States)

    Pickard, Barbara G.

    1996-01-01

    Two intellectual developments in the lab suggested a more powerful approach to the problem defined in the original statement. These were discussed with the "Program Chief', who agreed that an alteration of approach was desirable. Second expansion of our work was on the computational optical sectioning microscope (COSM). Additionally, we hoped to visualize the channels with respect to cytoskeletal entities. We have identified major here-to-fore unknown cytoskeletal structure in our representative experimental system, the onion epidermal cell, and have named this structure the endomembrane grant.

  12. Mechanotransduction and Growth Factor Signalling to Engineer Cellular Microenvironments.

    Science.gov (United States)

    Cipitria, Amaia; Salmeron-Sanchez, Manuel

    2017-08-01

    Engineering cellular microenvironments involves biochemical factors, the extracellular matrix (ECM) and the interaction with neighbouring cells. This progress report provides a critical overview of key studies that incorporate growth factor (GF) signalling and mechanotransduction into the design of advanced microenvironments. Materials systems have been developed for surface-bound presentation of GFs, either covalently tethered or sequestered through physico-chemical affinity to the matrix, as an alternative to soluble GFs. Furthermore, some materials contain both GF and integrin binding regions and thereby enable synergistic signalling between the two. Mechanotransduction refers to the ability of the cells to sense physical properties of the ECM and to transduce them into biochemical signals. Various aspects of the physics of the ECM, i.e. stiffness, geometry and ligand spacing, as well as time-dependent properties, such as matrix stiffening, degradability, viscoelasticity, surface mobility as well as spatial patterns and gradients of physical cues are discussed. To conclude, various examples illustrate the potential for cooperative signalling of growth factors and the physical properties of the microenvironment for potential applications in regenerative medicine, cancer research and drug testing. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Extension of Generalized Fluid System Simulation Program's Fluid Property Database

    Science.gov (United States)

    Patel, Kishan

    2011-01-01

    This internship focused on the development of additional capabilities for the General Fluid Systems Simulation Program (GFSSP). GFSSP is a thermo-fluid code used to evaluate system performance by a finite volume-based network analysis method. The program was developed primarily to analyze the complex internal flow of propulsion systems and is capable of solving many problems related to thermodynamics and fluid mechanics. GFSSP is integrated with thermodynamic programs that provide fluid properties for sub-cooled, superheated, and saturation states. For fluids that are not included in the thermodynamic property program, look-up property tables can be provided. The look-up property tables of the current release version can only handle sub-cooled and superheated states. The primary purpose of the internship was to extend the look-up tables to handle saturated states. This involves a) generation of a property table using REFPROP, a thermodynamic property program that is widely used, and b) modifications of the Fortran source code to read in an additional property table containing saturation data for both saturated liquid and saturated vapor states. Also, a method was implemented to calculate the thermodynamic properties of user-fluids within the saturation region, given values of pressure and enthalpy. These additions required new code to be written, and older code had to be adjusted to accommodate the new capabilities. Ultimately, the changes will lead to the incorporation of this new capability in future versions of GFSSP. This paper describes the development and validation of the new capability.

  14. Signal transduction pathways involved in mechanotransduction in bone cells

    International Nuclear Information System (INIS)

    Liedert, Astrid; Kaspar, Daniela; Blakytny, Robert; Claes, Lutz; Ignatius, Anita

    2006-01-01

    Several in vivo and in vitro studies with different loading regimens showed that mechanical stimuli have an influence on proliferation and differentiation of bone cells. Prerequisite for this influence is the transduction of mechanical signals into the cell, a phenomenon that is termed mechanotransduction, which is essential for the maintenance of skeletal homeostasis in adults. Mechanoreceptors, such as the integrins, cadherins, and stretch-activated Ca 2+ channels, together with various signal transduction pathways, are involved in the mechanotransduction process that ultimately regulates gene expression in the nucleus. Mechanotransduction itself is considered to be regulated by hormones, the extracellular matrix of the osteoblastic cells and the mode of the mechanical stimulus

  15. Mechanotransduction in Endothelial Cells Studied with Fluorescence Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Chien Shu [Departments of Bioengineering and Medicine and Institute of Engineering in Medicine, University of California, San Diego, La Jolla, California 92093-0427 (United States)

    2011-01-01

    Mechanotransduction involves the conversion of mechanical stimuli to intracellular signaling to modulate gene and protein expressions and hence cellular functions in endothelial cells, thus playing importance roles in the regulation of homeostasis in health and disease. The aim of this paper is to investigate the dynamics of mechanotransduction in endothelial cells by the use of fluorescent resonance energy transfer (FRET) to study the temporal and spatial activation of Src kinase and focal adhesion kinase, both of which play critical roles in many cellular processes. The results have contributed to the elucidation of the roles of these two important signaling molecules and their interactions in mediating mechanotransduction.

  16. Introduction to thermo-fluids systems design

    CERN Document Server

    Garcia McDonald, André

    2012-01-01

    A fully comprehensive guide to thermal systems design covering fluid dynamics, thermodynamics, heat transfer and thermodynamic power cycles Bridging the gap between the fundamental concepts of fluid mechanics, heat transfer and thermodynamics, and the practical design of thermo-fluids components and systems, this textbook focuses on the design of internal fluid flow systems, coiled heat exchangers and performance analysis of power plant systems. The topics are arranged so that each builds upon the previous chapter to convey to the reader that topics are not stand-alone i

  17. Rheological Influence Upon the Glomerular Podocyte and Resultant Mechanotransduction

    Directory of Open Access Journals (Sweden)

    Simona Pichler Sekulic

    2015-03-01

    Full Text Available The glomerular podocyte is exposed to numerous mechanical forces as a constituent of the glomerular filtration apparatus. This includes fluid shear stress (FSS displaced upon the podocytic foot process's apical, lateral, and basal surfaces. Even in the face of continuous flow the podocyte is capable of contributing to physiologic filtration, however with pathologic levels of hyperfiltration there is increased FSS placed upon the cell. The mechanisms by which the podocyte detects and responds to FSS are topics of recent investigations, with the aim to clarify the way these cells are injured and/or adapt in times of hyperfiltration and disease states. As the pathogenesis of numerous glomerulopathies is contingent on the status of the podocyte, understanding the manner that these cells can be modified by FSS is essential. Likewise, determination of the effect of such mechanical forces upon other resident cells of the renal corpuscle would reveal the contribution of FSS in the progression of glomerular diseases. The biochemical manner in which podocytes sense and respond to FSS, that is mechanotransduction, will be discussed.

  18. Capacitive system detects and locates fluid leaks

    Science.gov (United States)

    1966-01-01

    Electronic monitoring system automatically detects and locates minute leaks in seams of large fluid storage tanks and pipelines covered with thermal insulation. The system uses a capacitive tape-sensing element that is adhesively bonded over seams where fluid leaks are likely to occur.

  19. Integrins and extracellular matrix in mechanotransduction

    Directory of Open Access Journals (Sweden)

    Ramage L

    2011-12-01

    Full Text Available Lindsay RamageQueen’s Medical Research Institute, University of Edinburgh, Edinburgh, UKAbstract: Integrins are a family of cell surface receptors which mediate cell–matrix and cell–cell adhesions. Among other functions they provide an important mechanical link between the cells external and intracellular environments while the adhesions that they form also have critical roles in cellular signal-transduction. Cell–matrix contacts occur at zones in the cell surface where adhesion receptors cluster and when activated the receptors bind to ligands in the extracellular matrix. The extracellular matrix surrounds the cells of tissues and forms the structural support of tissue which is particularly important in connective tissues. Cells attach to the extracellular matrix through specific cell-surface receptors and molecules including integrins and transmembrane proteoglycans. Integrins work alongside other proteins such as cadherins, immunoglobulin superfamily cell adhesion molecules, selectins, and syndecans to mediate cell–cell and cell–matrix interactions and communication. Activation of adhesion receptors triggers the formation of matrix contacts in which bound matrix components, adhesion receptors, and associated intracellular cytoskeletal and signaling molecules form large functional, localized multiprotein complexes. Cell–matrix contacts are important in a variety of different cell and tissue properties including embryonic development, inflammatory responses, wound healing, and adult tissue homeostasis. This review summarizes the roles and functions of integrins and extracellular matrix proteins in mechanotransduction.Keywords: ligand binding, α subunit, ß subunit, focal adhesion, cell differentiation, mechanical loading, cell–matrix interaction

  20. Role of TRP Channels in Dinoflagellate Mechanotransduction.

    Science.gov (United States)

    Lindström, J B; Pierce, N T; Latz, M I

    2017-10-01

    Transient receptor potential (TRP) ion channels are common components of mechanosensing pathways, mainly described in mammals and other multicellular organisms. To gain insight into the evolutionary origins of eukaryotic mechanosensory proteins, we investigated the involvement of TRP channels in mechanosensing in a unicellular eukaryotic protist, the dinoflagellate Lingulodinium polyedra. BLASTP analysis of the protein sequences predicted from the L. polyedra transcriptome revealed six sequences with high similarity to human TRPM2, TRPM8, TRPML2, TRPP1, and TRPP2; and characteristic TRP domains were identified in all sequences. In a phylogenetic tree including all mammalian TRP subfamilies and TRP channel sequences from unicellular and multicellular organisms, the L. polyedra sequences grouped with the TRPM, TPPML, and TRPP clades. In pharmacological experiments, we used the intrinsic bioluminescence of L. polyedra as a reporter of mechanoresponsivity. Capsaicin and RN1734, agonists of mammalian TRPV, and arachidonic acid, an agonist of mammalian TRPV, TRPA, TRPM, and Drosophila TRP, all stimulated bioluminescence in L. polyedra. Mechanical stimulation of bioluminescence, but not capsaicin-stimulated bioluminescence, was inhibited by gadolinium (Gd 3+ ), a general inhibitor of mechanosensitive ion channels, and the phospholipase C (PLC) inhibitor U73122. These pharmacological results are consistent with the involvement of TRP-like channels in mechanosensing by L. polyedra. The TRP channels do not appear to be mechanoreceptors but rather are components of the mechanotransduction signaling pathway and may be activated via a PLC-dependent mechanism. The presence and function of TRP channels in a dinoflagellate emphasize the evolutionary conservation of both the channel structures and their functions.

  1. Control system for fluid heated steam generator

    Science.gov (United States)

    Boland, J.F.; Koenig, J.F.

    1984-05-29

    A control system for controlling the location of the nucleate-boiling region in a fluid heated steam generator comprises means for measuring the temperature gradient (change in temperature per unit length) of the heating fluid along the steam generator; means for determining a control variable in accordance with a predetermined function of temperature gradients and for generating a control signal in response thereto; and means for adjusting the feedwater flow rate in accordance with the control signal.

  2. Selection of fluids for tritium pumping systems

    International Nuclear Information System (INIS)

    Chastagner, P.

    1984-02-01

    The degradation characteristics of three types of vacuum pump fluids, polyphenyl ethers, perfluoropolyethers and hydrocarbon oils were reviewed. Fluid selection proved to be a critical factor in the long-term performance of tritium pumping systems and subsequent tritium recovery operations. Thermal degradation and tritium radiolysis of pump fluids produce contaminants which can damage equipment and interfere with tritium recovery operations. General characteristics of these fluids are as follows: polyphenyl ether has outstanding radiation resistance, is very stable under normal diffusion pump conditions, but breaks down in the presence of oxygen at anticipated operating temperatures. Perfluoropolyether fluids are very stable and do not react chemically with most gases. Thermal and mechanical degradation products are inert, but the radiolysis products are very corrosive. Most of the degradation products of hydrogen oils are volatile and the principal radiolysis product is methane. Our studies show that polyphenyl ethers and hydrocarbon oils are the preferred fluids for use in tritium pumping systems. No corrosive materials are formed and most of the degradation products can be removed with suitable filter systems

  3. Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels.

    Science.gov (United States)

    Zhao, Qiancheng; Wu, Kun; Geng, Jie; Chi, Shaopeng; Wang, Yanfeng; Zhi, Peng; Zhang, Mingmin; Xiao, Bailong

    2016-03-16

    Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our finding of the miniature pore-forming module of Piezo1 that resembles the pore architecture of other trimeric channels and encodes the essential pore properties. We further identified specific residues within the pore module that determine unitary conductance, pore blockage and ion selectivity for divalent and monovalent cations and anions. The non-pore-containing region of Piezo1 confers mechanosensitivity to mechano-insensitive trimeric acid-sensing ion channels, demonstrating that Piezo1 channels possess intrinsic mechanotransduction modules separate from their pore modules. In conclusion, this is the first report on the bona fide pore module and mechanotransduction components of Piezo channels, which define their ion-conducting properties and gating by mechanical stimuli, respectively. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Orbital Express fluid transfer demonstration system

    Science.gov (United States)

    Rotenberger, Scott; SooHoo, David; Abraham, Gabriel

    2008-04-01

    Propellant resupply of orbiting spacecraft is no longer in the realm of high risk development. The recently concluded Orbital Express (OE) mission included a fluid transfer demonstration that operated the hardware and control logic in space, bringing the Technology Readiness Level to a solid TRL 7 (demonstration of a system prototype in an operational environment). Orbital Express (funded by the Defense Advanced Research Projects Agency, DARPA) was launched aboard an Atlas-V rocket on March 9th, 2007. The mission had the objective of demonstrating technologies needed for routine servicing of spacecraft, namely autonomous rendezvous and docking, propellant resupply, and orbital replacement unit transfer. The demonstration system used two spacecraft. A servicing vehicle (ASTRO) performed multiple dockings with the client (NextSat) spacecraft, and performed a variety of propellant transfers in addition to exchanges of a battery and computer. The fluid transfer and propulsion system onboard ASTRO, in addition to providing the six degree-of-freedom (6 DOF) thruster system for rendezvous and docking, demonstrated autonomous transfer of monopropellant hydrazine to or from the NextSat spacecraft 15 times while on orbit. The fluid transfer system aboard the NextSat vehicle was designed to simulate a variety of client systems, including both blowdown pressurization and pressure regulated propulsion systems. The fluid transfer demonstrations started with a low level of autonomy, where ground controllers were allowed to review the status of the demonstration at numerous points before authorizing the next steps to be performed. The final transfers were performed at a full autonomy level where the ground authorized the start of a transfer sequence and then monitored data as the transfer proceeded. The major steps of a fluid transfer included the following: mate of the coupling, leak check of the coupling, venting of the coupling, priming of the coupling, fluid transfer, gauging

  5. Reliable Fluid Power Pitch Systems

    DEFF Research Database (Denmark)

    Liniger, Jesper; Pedersen, Henrik Clemmensen; Soltani, Mohsen

    2015-01-01

    The key objectives of wind turbine manufactures and buyers are to reduce the Total Cost of Ownership and Total Cost of Energy. Among others, low downtime of a wind turbine is important to increase the amount of energy produced during its lifetime. Historical data indicate that pitch systems accou...

  6. Fluid Temperature of Aero Hydraulic Systems

    Directory of Open Access Journals (Sweden)

    I. S. Shumilov

    2016-01-01

    Full Text Available In modern supersonic aircrafts due to aerodynamic skin heating a temperature of hydraulics environment significantly exceeds that of permissible for fluids used. The same problem exists for subsonic passenger aircrafts, especially for Airbuses, which have hydraulics of high power where convective heat transfer with the environment is insufficient and there is no required temperature control of fluid. The most significant in terms of heat flow is the flow caused by the loss of power to the pump and when designing the hydraulic system (HS it is necessary to pay very serious attention to it. To use a constant capacity pump is absolutely unacceptable, since HS efficiency in this case is extremely low, and the most appropriate are variable-capacity pumps, cut-off pumps, dual-mode pumps. The HS fluid cooling system should provide high reliability, lightweight, simple design, and a specified heat transfer in all flight modes.A system cooling the fluid by the fuel of feeding lines of the aircraft engines is the most effective, and it is widely used in supersonic aircrafts, where power of cooling system is essential. Subsonic aircrafts widely use convective heat exchangers. In thermal design of the aircraft hydraulics, the focus is generally given to the maximum and minimum temperatures of the HS fluid, the choice of the type of heat exchanger (convective or flow-through, the place of its installation. In calculating the operating temperature of a hydraulic system and its cooling systems it is necessary to determine an increase of the working fluid temperature when throttling it. There are three possible formulas to calculate the fluid temperature in throttling, with the error of a calculated temperature drop from 30% to 4%.The article considers the HS stationary and noon-stationary operating conditions and their calculation, defines temperatures of fluid and methods to control its specified temperature. It also discusses various heat exchanger schemes

  7. Fluid structure interaction in piping systems

    Energy Technology Data Exchange (ETDEWEB)

    Svingen, Bjoernar

    1996-12-31

    The Dr. ing. thesis relates to an analysis of fluid structure interaction in piping systems in the frequency domain. The governing equations are the water hammer equations for the liquid, and the beam-equations for the structure. The fluid and structural equations are coupled through axial stresses and fluid continuity relations controlled by the contraction factor (Poisson coupling), and continuity and force relations at the boundaries (junction coupling). A computer program has been developed using the finite element method as a discretization technique both for the fluid and for the structure. This is made for permitting analyses of large systems including branches and loops, as well as including hydraulic piping components, and experiments are executed. Excitations are made in a frequency range from zero Hz and up to at least one thousand Hz. Frequency dependent friction is modelled as stiffness proportional Rayleigh damping both for the fluid and for the structure. With respect to the water hammer equations, stiffness proportional damping is seen as an artificial (bulk) viscosity term. A physical interpretation of this term in relation to transient/oscillating hydraulic pipe-friction is given. 77 refs., 72 figs., 4 tabs.

  8. The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction.

    Directory of Open Access Journals (Sweden)

    Yanghui Xing

    Full Text Available We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction. In this study, our objective was to further investigate, using a knockout mouse model, the roles of P2Y2 receptors in bone mechanobiology. We first examined bone structure with micro-CT and measured bone mechanical properties with three point bending experiments in both wild type mice and P2Y2 knockout mice. We found that bones from P2Y2 knockout mice have significantly decreased bone volume, bone thickness, bone stiffness and bone ultimate breaking force at 17 week old age. In order to elucidate the mechanisms by which P2Y2 receptors contribute to bone biology, we examined differentiation and mineralization of bone marrow cells from wild type and P2Y2 knockout mice. We found that P2Y2 receptor deficiency reduces the differentiation and mineralization of bone marrow cells. Next, we compared the response of primary osteoblasts, from both wild type and P2Y2 knockout mice, to ATP and mechanical stimulation (oscillatory fluid flow, and found that osteoblasts from wild type mice have a stronger response, in terms of ERK1/2 phosphorylation, to both ATP and fluid flow, relative to P2Y2 knockout mice. However, we did not detect any difference in ATP release in response to fluid flow between wild type and P2Y2 knock out osteoblasts. Our findings suggest that P2Y2 receptors play important roles in bone marrow cell differentiation and mineralization as well as in bone cell mechanotransduction, leading to an osteopenic phenotype in P2Y2 knockout mice.

  9. Fluid biomarkers in multiple system atrophy

    DEFF Research Database (Denmark)

    Laurens, Brice; Constantinescu, Radu; Freeman, Roy

    2015-01-01

    Despite growing research efforts, no reliable biomarker currently exists for the diagnosis and prognosis of multiple system atrophy (MSA). Such biomarkers are urgently needed to improve diagnostic accuracy, prognostic guidance and also to serve as efficacy measures or surrogates of target...... engagement for future clinical trials. We here review candidate fluid biomarkers for MSA and provide considerations for further developments and harmonization of standard operating procedures. A PubMed search was performed until April 24, 2015 to review the literature with regard to candidate blood...... and cerebrospinal fluid (CSF) biomarkers for MSA. Abstracts of 1760 studies were retrieved and screened for eligibility. The final list included 60 studies assessing fluid biomarkers in patients with MSA. Most studies have focused on alpha-synuclein, markers of axonal degeneration or catecholamines. Their results...

  10. Damping system immersed in a fluid

    International Nuclear Information System (INIS)

    1980-01-01

    The invention relates to a damping system which is immersed in a fluid and allows slow motion, while opposing fast motion of a mobile or deformable system immersed in a fluid. Nuclear reactors utilize fabricated assemblies immmersed in the spent fuel storage pool to support the fuel elements placed in the pool, e.g., when refueling the reactor. These fabricated assemblies must be held in position, relative to the concrete walls of the pool, so as to allow slow deformation of the assemblies due to thermal expansion, while curbing fast motion, e.g., earthquake-induced motion. Such fast motion due to earthquakes might be the cause of resonance phenomena involving the fuel storage rack structure and the pool walls, should the rack structure and pool walls have the same resonant frequency. In the event of an earthquake, the damping system would provide for fast curbing of structure motion to prevent uncontrolled deformation which might result in breaks and destruction [fr

  11. The cellular mastermind(?) – Mechanotransduction and the nucleus

    Science.gov (United States)

    Kaminski, Ashley; Fedorchak, Gregory R.; Lammerding, Jan

    2015-01-01

    Cells respond to mechanical stimulation by activation of specific signaling pathways and genes that allow the cell to adapt to its dynamic physical environment. How cells sense the various mechanical inputs and translate them into biochemical signals remains an area of active investigation. Recent reports suggest that the cell nucleus may be directly implicated in this cellular mechanotransduction process. In this chapter, we discuss how forces applied to the cell surface and cytoplasm induce changes in nuclear structure and organization, which could directly affect gene expression, while also highlighting the complex interplay between nuclear structural proteins and transcriptional regulators that may further modulate mechanotransduction signaling. Taken together, these findings paint a picture of the nucleus as a central hub in cellular mechanotransduction—both structurally and biochemically—with important implications in physiology and disease. PMID:25081618

  12. The imperative for controlled mechanical stresses in unraveling cellular mechanisms of mechanotransduction

    Directory of Open Access Journals (Sweden)

    Sorkin Adam M

    2006-05-01

    Full Text Available Abstract Background In vitro mechanotransduction studies are designed to elucidate cell behavior in response to a well-defined mechanical signal that is imparted to cultured cells, e.g. through fluid flow. Typically, flow rates are calculated based on a parallel plate flow assumption, to achieve a targeted cellular shear stress. This study evaluates the performance of specific flow/perfusion chambers in imparting the targeted stress at the cellular level. Methods To evaluate how well actual flow chambers meet their target stresses (set for 1 and 10 dyn/cm2 for this study at a cellular level, computational models were developed to calculate flow velocity components and imparted shear stresses for a given pressure gradient. Computational predictions were validated with micro-particle image velocimetry (μPIV experiments. Results Based on these computational and experimental studies, as few as 66% of cells seeded along the midplane of commonly implemented flow/perfusion chambers are subjected to stresses within ±10% of the target stress. In addition, flow velocities and shear stresses imparted through fluid drag vary as a function of location within each chamber. Hence, not only a limited number of cells are exposed to target stress levels within each chamber, but also neighboring cells may experience different flow regimes. Finally, flow regimes are highly dependent on flow chamber geometry, resulting in significant variation in magnitudes and spatial distributions of stress between chambers. Conclusion The results of this study challenge the basic premise of in vitro mechanotransduction studies, i.e. that a controlled flow regime is applied to impart a defined mechanical stimulus to cells. These results also underscore the fact that data from studies in which different chambers are utilized can not be compared, even if the target stress regimes are comparable.

  13. A systems approach to theoretical fluid mechanics: Fundamentals

    Science.gov (United States)

    Anyiwo, J. C.

    1978-01-01

    A preliminary application of the underlying principles of the investigator's general system theory to the description and analyses of the fluid flow system is presented. An attempt is made to establish practical models, or elements of the general fluid flow system from the point of view of the general system theory fundamental principles. Results obtained are applied to a simple experimental fluid flow system, as test case, with particular emphasis on the understanding of fluid flow instability, transition and turbulence.

  14. Fluids in volcanic and geothermal systems

    Science.gov (United States)

    Sigvaldason, Gudmundur E.

    -rift volcanism is accordingly not fed directly by mantle derived liquids. The model predicts that all volcanic fluids, with the exception of those which are associated with the most primitive olivine tholeiites, are partly or wholly recycled through all stages of hydrothermal and metamorphic reactions. In that sense associated volcanic and geothermal systems are a part of the same chemical fractionation column. It is concluded that the chemistry of fluids in volcanic and geothermal systems can be viewed in the perspective of predictable crustal fractionation processes before any conclusion need be drawn concerning more deep seated causes for chemical anomalies.

  15. Fluid flow dynamics in MAS systems

    Science.gov (United States)

    Wilhelm, Dirk; Purea, Armin; Engelke, Frank

    2015-08-01

    The turbine system and the radial bearing of a high performance magic angle spinning (MAS) probe with 1.3 mm-rotor diameter has been analyzed for spinning rates up to 67 kHz. We focused mainly on the fluid flow properties of the MAS system. Therefore, computational fluid dynamics (CFD) simulations and fluid measurements of the turbine and the radial bearings have been performed. CFD simulation and measurement results of the 1.3 mm-MAS rotor system show relatively low efficiency (about 25%) compared to standard turbo machines outside the realm of MAS. However, in particular, MAS turbines are mainly optimized for speed and stability instead of efficiency. We have compared MAS systems for rotor diameter of 1.3-7 mm converted to dimensionless values with classical turbomachinery systems showing that the operation parameters (rotor diameter, inlet mass flow, spinning rate) are in the favorable range. This dimensionless analysis also supports radial turbines for low speed MAS probes and diagonal turbines for high speed MAS probes. Consequently, a change from Pelton type MAS turbines to diagonal turbines might be worth considering for high speed applications. CFD simulations of the radial bearings have been compared with basic theoretical values proposing considerably smaller frictional loss values. The discrepancies might be due to the simple linear flow profile employed for the theoretical model. Frictional losses generated inside the radial bearings result in undesired heat-up of the rotor. The rotor surface temperature distribution computed by CFD simulations show a large temperature gradient over the rotor.

  16. Complex Fluids in Energy Dissipating Systems

    Directory of Open Access Journals (Sweden)

    Francisco J. Galindo-Rosales

    2016-07-01

    Full Text Available The development of engineered systems for energy dissipation (or absorption during impacts or vibrations is an increasing need in our society, mainly for human protection applications, but also for ensuring the right performance of different sort of devices, facilities or installations. In the last decade, new energy dissipating composites based on the use of certain complex fluids have flourished, due to their non-linear relationship between stress and strain rate depending on the flow/field configuration. This manuscript intends to review the different approaches reported in the literature, analyses the fundamental physics behind them and assess their pros and cons from the perspective of their practical applications.

  17. Piezo1 regulates mechanotransductive release of ATP from human RBCs.

    Science.gov (United States)

    Cinar, Eyup; Zhou, Sitong; DeCourcey, James; Wang, Yixuan; Waugh, Richard E; Wan, Jiandi

    2015-09-22

    Piezo proteins (Piezo1 and Piezo2) are recently identified mechanically activated cation channels in eukaryotic cells and associated with physiological responses to touch, pressure, and stretch. In particular, human RBCs express Piezo1 on their membranes, and mutations of Piezo1 have been linked to hereditary xerocytosis. To date, however, physiological functions of Piezo1 on normal RBCs remain poorly understood. Here, we show that Piezo1 regulates mechanotransductive release of ATP from human RBCs by controlling the shear-induced calcium (Ca(2+)) influx. We find that, in human RBCs treated with Piezo1 inhibitors or having mutant Piezo1 channels, the amounts of shear-induced ATP release and Ca(2+) influx decrease significantly. Remarkably, a critical extracellular Ca(2+) concentration is required to trigger significant ATP release, but membrane-associated ATP pools in RBCs also contribute to the release of ATP. Our results show how Piezo1 channels are likely to function in normal RBCs and suggest a previously unidentified mechanotransductive pathway in ATP release. Thus, we anticipate that the study will impact broadly on the research of red cells, cellular mechanosensing, and clinical studies related to red cell disorders and vascular disease.

  18. Safety features of subcritical fluid fueled systems

    International Nuclear Information System (INIS)

    Bell, C.R.

    1995-01-01

    Accelerator-driven transmutation technology has been under study at Los Alamos for several years for application to nuclear waste treatment, tritium production, energy generation, and recently, to the disposition of excess weapons plutonium. Studies and evaluations performed to date at Los Alamos have led to a current focus on a fluid-fuel, fission system operating in a neutron source-supported subcritical mode, using molten salt reactor technology and accelerator-driven proton-neutron spallation. In this paper, the safety features and characteristics of such systems are explored from the perspective of the fundamental nuclear safety objectives that any reactor-type system should address. This exploration is qualitative in nature and uses current vintage solid-fueled reactors as a baseline for comparison. Based on the safety perspectives presented, such systems should be capable of meeting the fundamental nuclear safety objectives. In addition, they should be able to provide the safety robustness desired for advanced reactors. However, the manner in which safety objectives and robustness are achieved is very different from that associated with conventional reactors. Also, there are a number of safety design and operational challenges that will have to be addressed for the safety potential of such systems to be credible

  19. Safety features of subcritical fluid fueled systems

    International Nuclear Information System (INIS)

    Bell, C.R.

    1994-01-01

    Accelerator-driven transmutation technology has been under study at Los Alamos for several years for application to nuclear waste treatment, tritium production, energy generation, and recently, to the disposition of excess weapons plutonium. Studies and evaluations performed to date at Los Alamos have led to a current focus on a fluid-fuel, fission system operating in a neutron source-supported subcritical mode, using molten salt reactor technology and accelerator-driven proton-neutron spallation. In this paper, the safety features and characteristics of such systems are explored from the perspective of the fundamental nuclear safety objectives that any reactor-type system should address. This exploration is qualitative in nature and uses current vintage solid-fueled reactors as a baseline for comparison. Based on the safety perspectives presented, such systems should be capable of meeting the fundamental nuclear safety objectives. In addition, they should be able to provide the safety robustness desired for advanced reactors. However, the manner in which safety objectives and robustness are achieved in very different from that associated with conventional reactors. Also, there are a number of safety design and operational challenges that will have to be addressed for the safety potential of such systems to be credible

  20. Safety features of subcritical fluid fueled systems

    Energy Technology Data Exchange (ETDEWEB)

    Bell, C.R. [Los Alamos National Laboratory, NM (United States)

    1995-10-01

    Accelerator-driven transmutation technology has been under study at Los Alamos for several years for application to nuclear waste treatment, tritium production, energy generation, and recently, to the disposition of excess weapons plutonium. Studies and evaluations performed to date at Los Alamos have led to a current focus on a fluid-fuel, fission system operating in a neutron source-supported subcritical mode, using molten salt reactor technology and accelerator-driven proton-neutron spallation. In this paper, the safety features and characteristics of such systems are explored from the perspective of the fundamental nuclear safety objectives that any reactor-type system should address. This exploration is qualitative in nature and uses current vintage solid-fueled reactors as a baseline for comparison. Based on the safety perspectives presented, such systems should be capable of meeting the fundamental nuclear safety objectives. In addition, they should be able to provide the safety robustness desired for advanced reactors. However, the manner in which safety objectives and robustness are achieved is very different from that associated with conventional reactors. Also, there are a number of safety design and operational challenges that will have to be addressed for the safety potential of such systems to be credible.

  1. Method of calibrating a fluid-level measurement system

    Science.gov (United States)

    Woodard, Stanley E. (Inventor); Taylor, Bryant D. (Inventor)

    2010-01-01

    A method of calibrating a fluid-level measurement system is provided. A first response of the system is recorded when the system's sensor(s) is (are) not in contact with a fluid of interest. A second response of the system is recorded when the system's sensor(s) is (are) fully immersed in the fluid of interest. Using the first and second responses, a plurality of expected responses of the system's sensor(s) is (are) generated for a corresponding plurality of levels of immersion of the sensor(s) in the fluid of interest.

  2. Concept of planetary gear system to control fluid mixture ratio

    Science.gov (United States)

    Mcgroarty, J. D.

    1966-01-01

    Mechanical device senses and corrects for fluid flow departures from the selected flow ratio of two fluids. This system has been considered for control of rocket engine propellant mixture control but could find use wherever control of the flow ratio of any two fluids is desired.

  3. Heat transfer fluids for solar DHW systems

    Energy Technology Data Exchange (ETDEWEB)

    Wedel, S.; Bezzel, E.

    2000-07-01

    The aim of this work was to investigate the sudden clogging of the pipes in collectors as a consequence of liquid deterioration after repeated boiling during stagnation. A method to perform simple screening as accelerated tests of a large number liquid of samples subjected to various chemical- and physical environments have been designed. The acceleration factor of experiments relative to real systems is quite substantial primarily due to the extensive stress cycles in tests. Possible degradation mechanisms have been investigated and generally, there are two different paths to degradation of glycol: Thermal degradation and oxidative degradation primarily yielding propylene derivatives and carboxylic acids respectively. Polymerisation is an obvious possibility in a system containing various organic compounds such as acids and alcohols. Consequently, the reaction patterns alter making room for alternative interconnected mechanisms thus generating a broad spectrum of possible degradation products. Reserve alkalinity and pH are somewhat unreliable means of solely estimating the state of a liquid in relation to degradation and precipitation, as curvature of the RA-pH relations are different from liquid to liquid. For the majority of liquids, precipitation is not correlated with pH and RA. Coloration and precipitation in the liquid phase during stagnation separated liquids in two sub-categories. Fluids with inhibitor have sparing to moderate sedimentation and are brownish-black due to deterioration. Glycols without additives were either pale or colourless and did not precipitate. During normal operation, all fluids are clear and transparent and the majority has the same initial colour. The same distinction in liquids was observed on examination on the inside surface of the tubes concerning extent and the quantity of deposit. Liquids with additives tend to have significantly more deposit covering a larger surface than liquids without. Visual evaluation has proved that

  4. Mechanotransduction in cortical bone and the role of piezoelectricity: a numerical approach.

    Science.gov (United States)

    Stroe, M C; Crolet, J M; Racila, M

    2013-01-01

    This paper is a contribution to a plausible explanation of the mechanotransduction phenomenon in cortical bone during its remodelling. Our contribution deals only with the mechanical processes and the biological aspects have not been taken into account. It is well known that osteoblasts are able to generate bone in a suitable bony substitute only under fluid action. But the bone created in this manner is not organised to resist specific mechanical stress. Our aim was to suggest the nature of the physical information that can be transmitted - directly or via a biological or biochemical process - to the cell to initiate a cellular activity inducing the reconstruction of the osteon that is best adapted to local mechanical stresses. For this, the cell must have, from our point of view, a good knowledge of its structural environment. But this knowledge exists at the cellular scale while the bone is loaded at the macroscopic scale. This study is based on the SiNuPrOs model that allows exchange of information between the different structural scales of cortical bone. It shows that more than the fluid, the collagen - via its piezoelectric properties - plays an essential role in the transmission of information between the macroscopic and nanoscopic scales. Moreover, this process allows us to explain various dysfunctions and even some diseases.

  5. Studies of complexity in fluid systems

    Energy Technology Data Exchange (ETDEWEB)

    Nagel, Sidney R.

    2000-06-12

    This is the final report of Grant DE-FG02-92ER25119, ''Studies of Complexity in Fluids'', we have investigated turbulence, flow in granular materials, singularities in evolution of fluid surfaces and selective withdrawal fluid flows. We have studied numerical methods for dealing with complex phenomena, and done simulations on the formation of river networks. We have also studied contact-line deposition that occurs in a drying drop.

  6. Mechanotransduction across the cell surface and through the cytoskeleton

    Science.gov (United States)

    Wang, N.; Butler, J. P.; Ingber, D. E.

    1993-01-01

    Mechanical stresses were applied directly to cell surface receptors with a magnetic twisting device. The extracellular matrix receptor, integrin beta 1, induced focal adhesion formation and supported a force-dependent stiffening response, whereas nonadhesion receptors did not. The cytoskeletal stiffness (ratio of stress to strain) increased in direct proportion to the applied stress and required intact microtubules and intermediate filaments as well as microfilaments. Tensegrity models that incorporate mechanically interdependent struts and strings that reorient globally in response to a localized stress mimicked this response. These results suggest that integrins act as mechanoreceptors and transmit mechanical signals to the cytoskeleton. Mechanotransduction, in turn, may be mediated simultaneously at multiple locations inside the cell through force-induced rearrangements within a tensionally integrated cytoskeleton.

  7. Varicose Veins: Role of Mechanotransduction of Venous Hypertension

    Science.gov (United States)

    Atta, Hussein M.

    2012-01-01

    Varicose veins affect approximately one-third of the adult population and result in significant psychological, physical, and financial burden. Nevertheless, the molecular pathogenesis of varicose vein formation remains unidentified. Venous hypertension exerted on veins of the lower extremity is considered the principal factor in varicose vein formation. The role of mechanotransduction of the high venous pressure in the pathogenesis of varicose vein formation has not been adequately investigated despite a good progress in understanding the mechanomolecular mechanisms involved in transduction of high blood pressure in the arterial wall. Understanding the nature of the mechanical forces, the mechanosensors and mechanotransducers in the vein wall, and the downstream signaling pathways will provide new molecular targets for the prevention and treatment of varicose veins. This paper summarized the current understanding of mechano-molecular pathways involved in transduction of hemodynamic forces induced by blood pressure and tries to relate this information to setting of venous hypertension in varicose veins. PMID:22489273

  8. Novel Fluid Preservation System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — To address NASA's need for a method to preserve blood and urine samples from astronauts collected during flight, Chromologic (CL) proposes to develop a novel Fluid...

  9. Statistical mechanics of homogeneous partly pinned fluid systems.

    Science.gov (United States)

    Krakoviack, Vincent

    2010-12-01

    The homogeneous partly pinned fluid systems are simple models of a fluid confined in a disordered porous matrix obtained by arresting randomly chosen particles in a one-component bulk fluid or one of the two components of a binary mixture. In this paper, their configurational properties are investigated. It is shown that a peculiar complementarity exists between the mobile and immobile phases, which originates from the fact that the solid is prepared in presence of and in equilibrium with the adsorbed fluid. Simple identities follow, which connect different types of configurational averages, either relative to the fluid-matrix system or to the bulk fluid from which it is prepared. Crucial simplifications result for the computation of important structural quantities, both in computer simulations and in theoretical approaches. Finally, possible applications of the model in the field of dynamics in confinement or in strongly asymmetric mixtures are suggested.

  10. Fluid transportation mechanisms by a coupled system of elastic membranes and magnetic fluids

    International Nuclear Information System (INIS)

    Ido, Y.; Tanaka, K.; Sugiura, Y.

    2002-01-01

    The basic properties of the fluid transportation mechanism that is produced by the coupled waves propagating along a thin elastic membrane covering a magnetic fluid layer in a shallow and long rectangular vessel are investigated. It is shown that the progressive magnetic field induced by the rectangular pulses generates sinusoidal vibration of the displacement of elastic membrane and makes the system work more efficiently than the magnetic field induced by the pulse-width-modulation method

  11. Dipolar fluid-wall systems. Beyond the image potential

    International Nuclear Information System (INIS)

    Boudh-hir, M.E.

    1989-02-01

    The case of dipolar fluid in front of an ideal wall is examined. The surface-fluid system is introduced as a limit case of a binary mixture Using the diagrammatic development, the expansion of the one-particle distribution function is given. 16 refs

  12. Generalized Fluid System Simulation Program (GFSSP) Version 6 - General Purpose Thermo-Fluid Network Analysis Software

    Science.gov (United States)

    Majumdar, Alok; Leclair, Andre; Moore, Ric; Schallhorn, Paul

    2011-01-01

    GFSSP stands for Generalized Fluid System Simulation Program. It is a general-purpose computer program to compute pressure, temperature and flow distribution in a flow network. GFSSP calculates pressure, temperature, and concentrations at nodes and calculates flow rates through branches. It was primarily developed to analyze Internal Flow Analysis of a Turbopump Transient Flow Analysis of a Propulsion System. GFSSP development started in 1994 with an objective to provide a generalized and easy to use flow analysis tool for thermo-fluid systems.

  13. Intermediate Filaments at the Junction of Mechanotransduction, Migration, and Development

    Directory of Open Access Journals (Sweden)

    Rucha Sanghvi-Shah

    2017-09-01

    Full Text Available Mechanically induced signal transduction has an essential role in development. Cells actively transduce and respond to mechanical signals and their internal architecture must manage the associated forces while also being dynamically responsive. With unique assembly-disassembly dynamics and physical properties, cytoplasmic intermediate filaments play an important role in regulating cell shape and mechanical integrity. While this function has been recognized and appreciated for more than 30 years, continually emerging data also demonstrate important roles of intermediate filaments in cell signal transduction. In this review, with a particular focus on keratins and vimentin, the relationship between the physical state of intermediate filaments and their role in mechanotransduction signaling is illustrated through a survey of current literature. Association with adhesion receptors such as cadherins and integrins provides a critical interface through which intermediate filaments are exposed to forces from a cell's environment. As a consequence, these cytoskeletal networks are posttranslationally modified, remodeled and reorganized with direct impacts on local signal transduction events and cell migratory behaviors important to development. We propose that intermediate filaments provide an opportune platform for cells to both cope with mechanical forces and modulate signal transduction.

  14. Evaluation of New Fluid Mud Survey System at Field Sites

    National Research Council Canada - National Science Library

    Engler

    1992-01-01

    This technical note presents an intermediate evaluation of a fluid mud survey system with respect to operability, practicability, and repeatability based on field tests conducted at Calcasieu River, Louisiana...

  15. Smart Fluid System Dually Responsive to Light and Electric Fields: An Electrophotorheological Fluid.

    Science.gov (United States)

    Yoon, Chang-Min; Jang, Yoonsun; Noh, Jungchul; Kim, Jungwon; Jang, Jyongsik

    2017-10-24

    Electrophotorheological (EPR) fluids, whose rheological activity is dually responsive to light and electric fields (E fields), is formulated by mixing photosensitive spiropyran-decorated silica (SP-sSiO 2 ) nanoparticles with zwitterionic lecithin and mineral oil. A reversible photorheological (PR) activity of the EPR fluid is developed via the binding and releasing mechanism of lecithin and merocyanine (MC, a photoisomerized form of SP) under ultraviolet (UV) and visible (VIS) light applications. Moreover, the EPR fluid exhibits an 8-fold higher electrorheological (ER) performance compared to the SP-sSiO 2 nanoparticle-based ER fluid (without lecithin) under an E field, which is attributed to the enhanced dielectric properties facilitated by the binding of the lecithin and SP molecules. Upon dual application of UV light and an E field, the EPR fluid exhibits high EPR performance (ca. 115.3 Pa) that far exceeds its separate PR (ca. 0.8 Pa) and ER (ca. 57.5 Pa) activities, because of the synergistic contributions of the PR and ER effects through rigid and fully connected fibril-like structures. Consequently, this study offers a strategy on formulation of dual-stimuli responsive smart fluid systems.

  16. Reducing pressure oscillations in discrete fluid power systems

    DEFF Research Database (Denmark)

    Hansen, Anders Hedegaard; Pedersen, Henrik Clemmensen

    2016-01-01

    Discrete fluid power systems featuring transmission lines inherently include pressure oscillations. Experimental verification of a discrete fluid power power take off system for wave energy converters has shown the cylinder pressure to oscillate as force shifts are performed. This article investi...... investigates how cylinder pressure oscillations may be reduced by shaping the valve opening trajectory without the need for closed loop pressure feedback. Furthermore the energy costs of reducing pressure oscillations are investigated....

  17. The fluid systems for the SLD Cherenkov ring imaging detector

    International Nuclear Information System (INIS)

    Abe, K.; Hasegawa, K.; Hasegawa, Y.; Iwasaki, Y.; Suekane, F.; Yuta, H.; Baird, K.; Jacques, P.; Kalelkar, M.; Plano, R.; Stamer, P.; Word, G.; Bean, A.; Caldwell, D.O.; Duboscq, J.; Huber, J.; Lu, A.; Mathys, L.; McHugh, S.; Yellin, S.; Ben-David, R.; Manly, S.; Snyder, J.; Turk, J.; Cavalli-Sforza, M.; Coyle, P.; Coyne, D.; Gagnon, P.; Liu, X.; Schneider, M.; Williams, D.A.; Coller, J.; Shank, J.T.; Whitaker, J.S.; d'Oliveira, A.; Johnson, R.A.; Martinez, J.; Nussbaum, M.; Santha, A.K.S.; Sokoloff, M.D.; Stockdale, I.; Wilson, R.J.

    1992-10-01

    We describe the design and operation of the fluid delivery, monitor and control systems for the SLD barrel Cherenkov Ring Imaging Detector (CRID). The systems deliver drift gas (C 2 H 6 + TMAE), radiator gas (C 5 F 12 + N 2 ) and radiator liquid (C 6 F 14 ). Measured critical quantities such as electron lifetime in the drift gas and ultra-violet (UV) transparencies of the radiator fluids, together with the operational experience, are also reported

  18. Complex fluids in biological systems experiment, theory, and computation

    CERN Document Server

    2015-01-01

    This book serves as an introduction to the continuum mechanics and mathematical modeling of complex fluids in living systems. The form and function of living systems are intimately tied to the nature of surrounding fluid environments, which commonly exhibit nonlinear and history dependent responses to forces and displacements. With ever-increasing capabilities in the visualization and manipulation of biological systems, research on the fundamental phenomena, models, measurements, and analysis of complex fluids has taken a number of exciting directions. In this book, many of the world’s foremost experts explore key topics such as: Macro- and micro-rheological techniques for measuring the material properties of complex biofluids and the subtleties of data interpretation Experimental observations and rheology of complex biological materials, including mucus, cell membranes, the cytoskeleton, and blood The motility of microorganisms in complex fluids and the dynamics of active suspensions Challenges and solut...

  19. Magnetic nanofluids and magnetic composite fluids in rotating seal systems

    International Nuclear Information System (INIS)

    Borbath, T; Borbath, I; Boros, T; Bica, D; Vekas, L; Potencz, I

    2010-01-01

    Recent results are presented concerning the development of magnetofluidic leakage-free rotating seals for vacuum and high pressure gases, evidencing significant advantages compared to mechanical seals. The micro-pilot scale production of various types of magnetizable sealing fluids is shortly reviewed, in particular the main steps of the chemical synthesis of magnetic nanofluids and magnetic composite fluids with light hydrocarbon, mineral oil and synthetic oil carrier liquids. The behavior of different types of magnetizable fluids in the rotating sealing systems is analyzed. Design concepts, some constructive details and testing procedures of magnetofluidic rotating seals are presented such as the testing equipment. The main characteristics of several magnetofluidic sealing systems and their applications will be presented: vacuum deposition systems and liquefied gas pumps applications, mechanical and magnetic nanofluid combined seals, gas valves up to 40 bar equipped by rotating seal with magnetic nanofluids and magnetic composite fluids.

  20. Overview of Fluid System Design for the KJRR

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Seong Hoon; Park, Cheol; Kim, Young-Ki [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    This paper introduces the fluid system design to fulfill the above mentioned requirements. The considerations and design change experiences are also presented. The KJRR fluid system consists of four systems: Primary Cooling System (PCS), Safety Residual Heat Removal System (SRHRS), Pool Water management System (PWMS), and Hot Water Layer System (HWLS). The main purpose of the fluid system for a RR is to remove the heat generated in the core and to transfer it to the secondary cooling system in which the heat is dissipated in the atmosphere. In the open-pool type research reactor, it needs to cool, purify, and make up the pool water. The main purpose of the KJRR is to produce medical and industrial radioisotopes, such as Mo-99, Ir-192, I- 131 etc., and to irradiate silicon ingots for Neutron Transmutation Doping. The thermal power of the KJRR is 15 MW{sub t} and the maximum thermal neutron flux is 3.0 x 10{sup 14} n/cm{sup 2}s. The fuel type is LEU U-Mo plate type and the reflector is Beryllium and Graphite. The Reactor Structure Assembly is submerged in the reactor pool. The reactor core is cooled by a downward forced flow that is maintained by pumps. Due to the downward flow the fuel assembly can be fixed on the grid plate without using the special device. KAERI have been successfully operating HANARO and constructing the Jordan Research and Training Reactor (JRTR). Along with the KJRR project, the fluid system design for a medium power research reactor has been developed and matured from the economic and the safety point of view. The fluid system of the KJRR is introduced and the objective of each system is explained briefly. The fluid system in research reactors is designed to meet the requirements from the upstream design areas.

  1. Generalized Fluid System Simulation Program (GFSSP) - Version 6

    Science.gov (United States)

    Majumdar, Alok; LeClair, Andre; Moore, Ric; Schallhorn, Paul

    2015-01-01

    The Generalized Fluid System Simulation Program (GFSSP) is a finite-volume based general-purpose computer program for analyzing steady state and time-dependent flow rates, pressures, temperatures, and concentrations in a complex flow network. The program is capable of modeling real fluids with phase changes, compressibility, mixture thermodynamics, conjugate heat transfer between solid and fluid, fluid transients, pumps, compressors, flow control valves and external body forces such as gravity and centrifugal. The thermo-fluid system to be analyzed is discretized into nodes, branches, and conductors. The scalar properties such as pressure, temperature, and concentrations are calculated at nodes. Mass flow rates and heat transfer rates are computed in branches and conductors. The graphical user interface allows users to build their models using the 'point, drag, and click' method; the users can also run their models and post-process the results in the same environment. The integrated fluid library supplies thermodynamic and thermo-physical properties of 36 fluids, and 24 different resistance/source options are provided for modeling momentum sources or sinks in the branches. Users can introduce new physics, non-linear and time-dependent boundary conditions through user-subroutine.

  2. Linking rigid multibody systems via controllable thin fluid films

    DEFF Research Database (Denmark)

    Estupinan, Edgar Alberto; Santos, Ilmar

    2009-01-01

    , this paper gives a theoretical contribution to the combined fields of fluid–structure interaction and vibration control. The methodology is applied to a reciprocating linear compressor, where the dynamics of the mechanical components are described with help of multibody dynamics. The crank is linked......This work deals with the mathematical modelling of multibody systems interconnected via thin fluid films. The dynamics of the fluid films can be actively controlled by means of different types of actuators, allowing significant vibration reduction of the system components. In this framework...... to the rotor via a thin fluid film, where the hydrodynamic pressure is described by the Reynolds equation, which is modified to accommodate the controllable lubrication conditions. The fluid film forces are coupled to the set of nonlinear equations that describes the dynamics of the reciprocating linear...

  3. Dynamic analysis of multibody system immersed in a fluid medium

    International Nuclear Information System (INIS)

    Wu, R.W.; Liu, L.K.; Levy, S.

    1977-01-01

    This paper is concerned primarily with the development and evaluation of an analysis method for the reponse prediction of immersed systems to seismic and other dynamic excitations. For immersed multibody systems, the hydrodynamic interaction causes coupled motion among the solid bodies. Also, under intense external excitations, impact between bodies may occur. The complex character of such systems inhibit the use of conventional analytical solutions in closed form. Therefore, approximate numerical schemes have been devised. For an incompressible, inviscid fluid, the hydrodynamic forces exerted by the fluid on solid bodies are determined to be linearly proportional to the acceleration of the vibrating solid bodies; i.e., the presence of the fluid only affects the inertia of the solid body system. A finite element computer program has been developed for computing this hydrodynamic (or added) mass effect. This program can be used to determine the hydrodynamic mass of a two-dimensional fluid field with solid bodies of arbitrary geometry. Triangular elements and linear pressure interpolation function are used to discretize the fluid region. The component element method is used to determine the dynamic response of the multibody system to externally applied mechanical loading or support excitation. The present analysis method for predicting the dynamic response of submerged multibody system is quite general and pertains to any number of solid bodies. However in this paper, its application is demonstrated only for 4 and 25 body systems. (Auth.)

  4. Development of fluid and I and C systems design technology

    International Nuclear Information System (INIS)

    Sim, Yoon Sub; Park, C. K.; Kim, S. O.

    2000-05-01

    LMR is the reactor type that makes utilization of uranium resource very efficiently and the necessity of construction of a LMR in 2020's has been raised. However, the design technology required for construction has not been secured domestically. To fulfill the necessity, study has been made for the LMR system design technology and conceptual design of KALIMER systems for fluid, instrumentation, control, and protection have been developed. Also the computer code systems for the design and analysis of the KALIMER fluid systems have been developed. These study results are to used as the starting point of the next phase LMR design technology development research

  5. Wireless Fluid-Level Measurement System Equips Boat Owners

    Science.gov (United States)

    2008-01-01

    While developing a measurement acquisition system to be used to retrofit aging aircraft with vehicle health monitoring capabilities, Langley Research Center developed an innovative wireless fluid-level measurement system. The NASA technology was of interest to Tidewater Sensors LLC, of Newport News, Virginia, because of its many advantages over conventional fuel management systems, including its ability to provide an accurate measurement of volume while a boat is experiencing any rocking motion due to waves or people moving about on the boat. These advantages led the company to license this novel fluid-level measurement system from NASA for marine applications.

  6. Development of fluid and I and C systems design technology

    Energy Technology Data Exchange (ETDEWEB)

    Sim, Yoon Sub; Park, C. K.; Kim, S. O. [and others

    2000-05-01

    LMR is the reactor type that makes utilization of uranium resource very efficiently and the necessity of construction of a LMR in 2020's has been raised. However, the design technology required for construction has not been secured domestically. To fulfill the necessity, study has been made for the LMR system design technology and conceptual design of KALIMER systems for fluid, instrumentation, control, and protection have been developed. Also the computer code systems for the design and analysis of the KALIMER fluid systems have been developed. These study results are to used as the starting point of the next phase LMR design technology development research.

  7. Development of fluid and I and C systems design technology

    Energy Technology Data Exchange (ETDEWEB)

    Sim, Yoon Sub; Park, C K; Kim, S O [and others

    2000-05-01

    LMR is the reactor type that makes utilization of uranium resource very efficiently and the necessity of construction of a LMR in 2020's has been raised. However, the design technology required for construction has not been secured domestically. To fulfill the necessity, study has been made for the LMR system design technology and conceptual design of KALIMER systems for fluid, instrumentation, control, and protection have been developed. Also the computer code systems for the design and analysis of the KALIMER fluid systems have been developed. These study results are to used as the starting point of the next phase LMR design technology development research.

  8. Towards a smart non-invasive fluid loss measurement system.

    Science.gov (United States)

    Suryadevara, N K; Mukhopadhyay, S C; Barrack, L

    2015-04-01

    In this article, a smart wireless sensing non-invasive system for estimating the amount of fluid loss, a person experiences while physical activity is presented. The system measures three external body parameters, Heart Rate, Galvanic Skin Response (GSR, or skin conductance), and Skin Temperature. These three parameters are entered into an empirically derived formula along with the user's body mass index, and estimation for the amount of fluid lost is determined. The core benefit of the developed system is the affluence usage in combining with smart home monitoring systems to care elderly people in ambient assisted living environments as well in automobiles to monitor the body parameters of a motorist.

  9. Avoidance of Pressure Oscillations in Discrete Fluid Power Systems with Transmission Lines - An Analytical Approach

    DEFF Research Database (Denmark)

    Hansen, Anders Hedegaard; Pedersen, Henrik C.

    2014-01-01

    Discrete fluid power technology attracts great attention because it enables energy efficiency and robust system architectures. However, the discrete nature of this technology naturally brings shifting phenomenons into the picture. For fluid power system the relative high inductance of fluid...

  10. Lagrange formalism for a system of several fluids interacting electromagnetically

    International Nuclear Information System (INIS)

    Vuillemin, M.

    1964-01-01

    After giving the Lagrange expression for a conducting fluid in an external electromagnetic field, the author shows that a Lagrange expression exists for describing the evolution of a system of interacting fluids obtained by adding the Lagrange expression of each fluid.to that of the electromagnetic field. By variation are obtained the fluid movement equation coupled to the Maxwell equations. It is shown that the study of small movements around a stationary state can be deduced from the Lagrange equation expanded to the second power order of the perturbation. It is then possible to deduce the normal mode equations and the study the stability by examining the modes which are marginally stable. (author) [fr

  11. Generalized Fluid System Simulation Program, Version 5.0-Educational

    Science.gov (United States)

    Majumdar, A. K.

    2011-01-01

    The Generalized Fluid System Simulation Program (GFSSP) is a finite-volume based general-purpose computer program for analyzing steady state and time-dependent flow rates, pressures, temperatures, and concentrations in a complex flow network. The program is capable of modeling real fluids with phase changes, compressibility, mixture thermodynamics, conjugate heat transfer between solid and fluid, fluid transients, pumps, compressors and external body forces such as gravity and centrifugal. The thermofluid system to be analyzed is discretized into nodes, branches, and conductors. The scalar properties such as pressure, temperature, and concentrations are calculated at nodes. Mass flow rates and heat transfer rates are computed in branches and conductors. The graphical user interface allows users to build their models using the point, drag and click method; the users can also run their models and post-process the results in the same environment. The integrated fluid library supplies thermodynamic and thermo-physical properties of 36 fluids and 21 different resistance/source options are provided for modeling momentum sources or sinks in the branches. This Technical Memorandum illustrates the application and verification of the code through 12 demonstrated example problems.

  12. Body fluid matrix evaluation on a Roche cobas 8000 system.

    Science.gov (United States)

    Owen, William E; Thatcher, Mindy L; Crabtree, Karolyn J; Greer, Ryan W; Strathmann, Frederick G; Straseski, Joely A; Genzen, Jonathan R

    2015-09-01

    Chemical analysis of body fluids is commonly requested by physicians. Because most commercial FDA-cleared clinical laboratory assays are not validated by diagnostic manufacturers for "non-serum" and "non-plasma" specimens, laboratories may need to complete additional validation studies to comply with regulatory requirements regarding body fluid testing. The objective of this report is to perform recovery studies to evaluate potential body fluid matrix interferences for commonly requested chemistry analytes. Using an IRB-approved protocol, previously collected clinical body fluid specimens (biliary/hepatic, cerebrospinal, dialysate, drain, pancreatic, pericardial, peritoneal, pleural, synovial, and vitreous) were de-identified and frozen (-20°C) until experiments were performed. Recovery studies (spiking with high concentration serum, control, and/or calibrator) were conducted using 10% spiking solution by volume; n=5 specimens per analyte/body fluid investigated. Specimens were tested on a Roche cobas 8000 system (c502, c702, e602, and ISE modules). In all 80 analyte/body fluid combinations investigated (including amylase, total bilirubin, urea nitrogen, carbohydrate antigen 19-9, carcinoembryonic antigen, cholesterol, chloride, creatinine, glucose, potassium, lactate dehydrogenase, lipase, rheumatoid factor, sodium, total protein, triglycerides, and uric acid), the average percent recovery was within predefined acceptable limits (less than ±10% from the calculated ideal recovery). The present study provides evidence against the presence of any systematic matrix interference in the analyte/body fluid combinations investigated on the Roche cobas 8000 system. Such findings support the utility of ongoing body fluid validation initiatives conducted to maintain compliance with regulatory requirements. Copyright © 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  13. Determination of gas volume trapped in a closed fluid system

    Science.gov (United States)

    Hunter, W. F.; Jolley, J. E.

    1971-01-01

    Technique involves extracting known volume of fluid and measuring system before and after extraction, volume of entrapped gas is then computed. Formula derived from ideal gas laws is basis of this method. Technique is applicable to thermodynamic cycles and hydraulic systems.

  14. Fluid Delivery System For Capillary Electrophoretic Applications.

    Science.gov (United States)

    Li, Qingbo; Liu, Changsheng; Kane, Thomas E.; Kernan, John R.; Sonnenschein, Bernard; Sharer, Michael V.

    2002-04-23

    An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carrousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a gel delivery module containing a gel syringe/a stepper motor or a high pressure chamber with a pump to quickly and uniformly deliver gel through the capillary tubes. The system further includes a multi-wavelength beam generator to generate a laser beam which produces a beam with a wide range of wavelengths. An off-line capillary reconditioner thoroughly cleans a capillary cartridge to enable simultaneous execution of electrophoresis with another capillary cartridge. The streamlined nature of the off-line capillary reconditioner offers the advantage of increased system throughput with a minimal increase in system cost.

  15. LHC II system sensitivity to magnetic fluids

    CERN Document Server

    Cotae, Vlad

    2005-01-01

    Experiments have been designed to reveal the influences of ferrofluid treatment and static magnetic field exposure on the photosynthetic system II, where the light harvesting complex (LHC II) controls the ratio chlorophyll a/ chlorophyll b (revealing, indirectly, the photosynthesis rate). Spectrophotometric measurement of chlorophyll content revealed different influences for relatively low ferrofluid concentrations (10-30 mul/l) in comparison to higher concentrations (70-100 mul/l). The overlapped effect of the static magnetic field shaped better the stimulatory ferrofluid action on LHC II system in young poppy plantlets.

  16. Overview of NSSS Fluid System Design of PGSFR

    Energy Technology Data Exchange (ETDEWEB)

    Han, Ji-Woong; Choi, Seok-Ki; Kim, Seong-O; Kim, Eui-Kwang; Kim, Dehee; Hong, Jonggan; Ye, Huee-Youl; Yeom, Sujin; Ryu, Seungho; Yoon, Jung; Choi, Sun Rock; Park, Jin-Seok; Lee, Tae-Ho Lee [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    In this paper an overview on the NSSS fluid system design of PGSFR is described based on the issued design documents. System concepts and major components design concepts for PHTS, IHTS, DHRS and SWRPRS were developed. Thermal-hydraulic characteristics were analyzed based on CFD simulation. The design bases and concepts for auxiliary systems were also developed. The upstream design requirements of fluid system such as system design requirements, component design requirements, I and C design requirements, BOP interface design requirements, design guides and P and IDs were produced. The control logic and computer code for the analysis for operational characteristics is under progress. The protection system consists of a safety grade PPS and a non-safety grade DPS (Diverse Protection System). The DPS provides a diverse method to trip the reactor to satisfy the requirements relative to ATWS (Anticipated Transients Without Scram) as well as Defense-In-Depth and Diversity.

  17. Systems and methods for multi-fluid geothermal energy systems

    Science.gov (United States)

    Buscheck, Thomas A.

    2017-09-19

    A method for extracting geothermal energy from a geothermal reservoir formation. A production well is used to extract brine from the reservoir formation. At least one of nitrogen (N.sub.2) and carbon dioxide (CO.sub.2) may be used to form a supplemental working fluid which may be injected into a supplemental working fluid injection well. The supplemental working fluid may be used to augment a pressure of the reservoir formation, to thus drive a flow of the brine out from the reservoir formation.

  18. Improved design features of KSNP+ BOP Fluid System

    International Nuclear Information System (INIS)

    Park, Heung Gyu; Yoon, Kyung Sup

    2002-01-01

    KOPEC (Korea Power Engineering Co.) in conjunction with the client KHNP (Korea Hydro and Nuclear Power Co.) has been developing the KSNP + (Improved Korean Standard Nuclear Power Plants) design concept since 1998. The main objective of the KSNP + is to enhance safety and economy of KSNP. The design concepts of the KSNP + will be implemented in Shin-Kori Units 1 and 2 Shin-Wolsung Units 1 and 2. This paper provides on an introduction to the improved design features of the KSNP + BOP fluid system consisting of 45 design improvement items. The design improvement concepts of the BOP fluid system have been developed as follows: optimization of system configuration and capacity, simplification of system, and adoption of advanced design features. Improved design features of the BOP fluid system allow additional benefits due to making a contribution to the optimization of plant arrangement and the reduction of operating costs during the plant life time. In conclusion, design improvement to the BOP fluid system have contributed to the KSNP + design concept being more reliable, safe and economically competitive

  19. Gravitational equilibrium of a multi-body fluid system

    International Nuclear Information System (INIS)

    Eriguchi, Yoshiharu; Hachisu, Izumi.

    1983-01-01

    We have computed gravitational equilibrium sequences for systems consisting of N incompressible fluid bodies (N = 3, 4, 5). The component fluids are assumed congruent. The system seems to become a lobe-like shape for N = 3 case and a ring-like shape for N>=4 cases according as the fluid bodies come nearer to each other. For every sequence there is a critical equilibrium whose dimensionless angular momentum has the minimum value of the sequence. As the final outcome is nearly in equilibrium in the computation of a collapsing gas cloud, we can apply the present results to the interpretation of these dynamical calculations. For instance, the gas cloud can never fissure into any N-body equilibrium when its dimensionless angular momentum is below the critical value of the N-body sequence. (author)

  20. An integrated in-line fluid characterization system for industrial applications(In-situ fluid mechanics experiments)

    OpenAIRE

    Johan, Wiklund; Reinhardt, Kotze; Beat, Birkhofer; Stefano, Ricci; Valentino, Meacci; Mats, Stading; Rainer, Haldenwang; SP-Technical Research Institute of Sweden; FPRC, Cape Peninsula University of Technology; Sika Services AG; Information Engineering Department - University of Florence; Information Engineering Department - University of Florence; SP-Technical Research Institute of Sweden; FPRC, Cape Peninsula University of Technology

    2015-01-01

    In this work we have presented the world's first commercially available embedded in-line fluids characterization system, "Flow-Viz". It has been specifically designed for the non-invasive, in-line, continuous, real-time velocity profile and rheological assessment of opaque, non-Newtonian industrial fluids. The Flow-Viz system has been successfully installed in pilot plants of international companies and used also for academic research. The technology has been applied to a wide range of fluids...

  1. Generalized Fluid System Simulation Program, Version 6.0

    Science.gov (United States)

    Majumdar, A. K.; LeClair, A. C.; Moore, R.; Schallhorn, P. A.

    2016-01-01

    The Generalized Fluid System Simulation Program (GFSSP) is a general purpose computer program for analyzing steady state and time-dependent flow rates, pressures, temperatures, and concentrations in a complex flow network. The program is capable of modeling real fluids with phase changes, compressibility, mixture thermodynamics, conjugate heat transfer between solid and fluid, fluid transients, pumps, compressors, and external body forces such as gravity and centrifugal. The thermofluid system to be analyzed is discretized into nodes, branches, and conductors. The scalar properties such as pressure, temperature, and concentrations are calculated at nodes. Mass flow rates and heat transfer rates are computed in branches and conductors. The graphical user interface allows users to build their models using the 'point, drag, and click' method; the users can also run their models and post-process the results in the same environment. Two thermodynamic property programs (GASP/WASP and GASPAK) provide required thermodynamic and thermophysical properties for 36 fluids: helium, methane, neon, nitrogen, carbon monoxide, oxygen, argon, carbon dioxide, fluorine, hydrogen, parahydrogen, water, kerosene (RP-1), isobutene, butane, deuterium, ethane, ethylene, hydrogen sulfide, krypton, propane, xenon, R-11, R-12, R-22, R-32, R-123, R-124, R-125, R-134A, R-152A, nitrogen trifluoride, ammonia, hydrogen peroxide, and air. The program also provides the options of using any incompressible fluid with constant density and viscosity or ideal gas. The users can also supply property tables for fluids that are not in the library. Twenty-four different resistance/source options are provided for modeling momentum sources or sinks in the branches. These options include pipe flow, flow through a restriction, noncircular duct, pipe flow with entrance and/or exit losses, thin sharp orifice, thick orifice, square edge reduction, square edge expansion, rotating annular duct, rotating radial duct

  2. What Does Dynamical Systems Theory Teach Us about Fluids?

    International Nuclear Information System (INIS)

    Bosetti, Hadrien; Posch, Harald A.

    2014-01-01

    We use molecular dynamics simulations to compute the Lyapunov spectra of many-particle systems resembling simple fluids in thermal equilibrium and in non-equilibrium stationary states. Here we review some of the most interesting results and point to open questions. (general)

  3. Cellular Biotechnology Operations Support System Fluid Dynamics Investigation

    Science.gov (United States)

    2003-01-01

    Aboard the International Space Station (ISS), the Tissue Culture Medium (TCM) is the bioreactor vessel in which cell cultures are grown. With its two syringe ports, it is much like a bag used to administer intravenous fluid, except it allows gas exchange needed for life. The TCM contains cell culture medium, and when frozen cells are flown to the ISS, they are thawed and introduced to the TCM through the syringe ports. In the Cellular Biotechnology Operations Support System-Fluid Dynamics Investigation (CBOSS-FDI) experiment, several mixing procedures are being assessed to determine which method achieves the most uniform mixing of growing cells and culture medium.

  4. In Touch With the Mechanosensitive Piezo Channels: Structure, Ion Permeation, and Mechanotransduction.

    Science.gov (United States)

    Geng, J; Zhao, Q; Zhang, T; Xiao, B

    2017-01-01

    Mechanotransduction, the conversion of mechanical forces into biological signals, plays critical roles in various physiological and pathophysiological processes in mammals, such as conscious sensing of touch, pain, and sound, as well as unconscious sensing of blood flow-associated shear stress, urine flow, and bladder distention. Among the various molecules involved in mechanotransduction, mechanosensitive (MS) cation channels have long been postulated to represent one critical class of mechanotransducers that directly and rapidly converts mechanical force into electrochemical signals. Despite the awareness of their functional significance, the molecular identities of MS cation channels in mammals had remained elusive for decades till the groundbreaking finding that the Piezo family of genes, including Piezo1 and Piezo2, constitutes their essential components. Since their identification about 6years ago, tremendous progress has been made in understanding their physiological and pathophysiological importance in mechanotransduction and their structure-function relationships of being the prototypic class of mammalian MS cation channels. On the one hand, Piezo proteins have been demonstrated to serve as physiologically and pathophysiologically important mechanotransducers for most, if not all, mechanotransduction processes. On the other hand, they have been shown to form a remarkable three-bladed, propeller-shaped homotrimeric channel complex comprising a separable ion-conducting pore module and mechanotransduction modules. In this chapter, we review the major advancements, with a particular focus on the structural and biophysical features that enable Piezo proteins to serve as sophisticated MS cation channels for force sensing, transduction, and ion conduction. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Computational Fluid and Particle Dynamics in the Human Respiratory System

    CERN Document Server

    Tu, Jiyuan; Ahmadi, Goodarz

    2013-01-01

    Traditional research methodologies in the human respiratory system have always been challenging due to their invasive nature. Recent advances in medical imaging and computational fluid dynamics (CFD) have accelerated this research. This book compiles and details recent advances in the modelling of the respiratory system for researchers, engineers, scientists, and health practitioners. It breaks down the complexities of this field and provides both students and scientists with an introduction and starting point to the physiology of the respiratory system, fluid dynamics and advanced CFD modeling tools. In addition to a brief introduction to the physics of the respiratory system and an overview of computational methods, the book contains best-practice guidelines for establishing high-quality computational models and simulations. Inspiration for new simulations can be gained through innovative case studies as well as hands-on practice using pre-made computational code. Last but not least, students and researcher...

  6. Adaptation of systems to fluid changes; Adaptation des systemes aux changements de fluides

    Energy Technology Data Exchange (ETDEWEB)

    Clodic, D. [Ecole Nationale Superieure des Mines, 75 - Paris (France)

    1996-12-31

    Regulation constraints and the stoppage of CFCs production and HCFCs production in the future lead to rapid evolutions in the conceiving of refrigerating installations which are linked with refrigerant changes. The refrigerant/installation pair has become the aim of detailed analyses in order to understand the relation between the thermodynamical properties of fluids and the energy efficiency of refrigerating installations. The efficiency depends entirely on the global design of the installation while the choice of the fluid is only one element that contributes to this efficiency. This paper analyzes successively: the consequences of pure refrigerant substitution on volume and centrifugal compressors, and the constraints linked with the use of mixtures close to azeotropic compounds (R408A and R404A) and mixtures with temperature shift like R407C. In this last case, the replacement is deeply different in the case of water heat exchangers and in the case of air-circulation heat exchangers. (J.S.) 3 refs.

  7. Numerical Cerebrospinal System Modeling in Fluid-Structure Interaction.

    Science.gov (United States)

    Garnotel, Simon; Salmon, Stéphanie; Balédent, Olivier

    2018-01-01

    Cerebrospinal fluid (CSF) stroke volume in the aqueduct is widely used to evaluate CSF dynamics disorders. In a healthy population, aqueduct stroke volume represents around 10% of the spinal stroke volume while intracranial subarachnoid space stroke volume represents 90%. The amplitude of the CSF oscillations through the different compartments of the cerebrospinal system is a function of the geometry and the compliances of each compartment, but we suspect that it could also be impacted be the cardiac cycle frequency. To study this CSF distribution, we have developed a numerical model of the cerebrospinal system taking into account cerebral ventricles, intracranial subarachnoid spaces, spinal canal and brain tissue in fluid-structure interactions. A numerical fluid-structure interaction model is implemented using a finite-element method library to model the cerebrospinal system and its interaction with the brain based on fluid mechanics equations and linear elasticity equations coupled in a monolithic formulation. The model geometry, simplified in a first approach, is designed in accordance with realistic volume ratios of the different compartments: a thin tube is used to mimic the high flow resistance of the aqueduct. CSF velocity and pressure and brain displacements are obtained as simulation results, and CSF flow and stroke volume are calculated from these results. Simulation results show a significant variability of aqueduct stroke volume and intracranial subarachnoid space stroke volume in the physiological range of cardiac frequencies. Fluid-structure interactions are numerous in the cerebrospinal system and difficult to understand in the rigid skull. The presented model highlights significant variations of stroke volumes under cardiac frequency variations only.

  8. A gun recoil system employing a magnetorheological fluid damper

    International Nuclear Information System (INIS)

    Li, Z C; Wang, J

    2012-01-01

    This research aims to design and control a full scale gun recoil buffering system which works under real firing impact loading conditions. A conventional gun recoil absorber is replaced with a controllable magnetorheological (MR) fluid damper. Through dynamic analysis of the gun recoil system, a theoretical model for optimal design and control of the MR fluid damper for impact loadings is derived. The optimal displacement, velocity and optimal design rules are obtained. By applying the optimal design theory to protect against impact loadings, an MR fluid damper for a full scale gun recoil system is designed and manufactured. An experimental study is carried out on a firing test rig which consists of a 30 mm caliber, multi-action automatic gun with an MR damper mounted to the fixed base through a sliding guide. Experimental buffering results under passive control and optimal control are obtained. By comparison, optimal control is better than passive control, because it produces smaller variation in the recoil force while achieving less displacement of the recoil body. The optimal control strategy presented in this paper is open-loop with no feedback system needed. This means that the control process is sensor-free. This is a great benefit for a buffering system under impact loading, especially for a gun recoil system which usually works in a harsh environment. (paper)

  9. Reviewing fluid systems for age-related degradation

    International Nuclear Information System (INIS)

    Smith, Stan

    1991-01-01

    Yankee Atomic Electric Company has developed the component degradation assessment tool (CoDAT), an expert system, that aids in handling and evaluating the large amounts of data required to support the license renewal process for nuclear power station fluid systems. In 1990, CoDAT evaluated the Yankee Nuclear Power Station fluid systems for age-related degradation. Its results are now being used to help focus the plant's maintenance programs and manage the expected degradation. CoDAT uses 'If-Then' rules, developed from industry codes, standards and publications, to determine the potential for 19 age-related degradation mechanisms. Other nuclear utilities pursuing the license renewal option also could use CoDAT. (author)

  10. Fluid moderator control system reactor internals distribution system

    International Nuclear Information System (INIS)

    Fensterer, H.F.; Klassen, W.E.; Veronesi, L.; Boyle, D.E.; Salton, R.B.

    1987-01-01

    This patent describes a spectral shift pressurized water nuclear reactor employing a low neutron moderating fluid for the spectral shift including a reactor pressure vessel, a core comprising a plurality of fuel assemblies, a core support plate, apparatus comprising means for penetrating the reactor vessel for introducing the moderating fluid into the reactor vessel. Means associated with the core support plate for directly distributing the moderating fluid to and from the fuel assemblies comprises at least one inlet flow channel in the core plate; branch inlet feed lines connect to the inlet flow channel in the core plate; vertical inlet flow lines flow connected to the branch inlet feed lines; each vertical flow line communicates with a fuel assembly; the distribution means further comprise lines serving as return flow lines, each of which is connected to one of the fuel assemblies; branch exit flow lines in the core plate flow connected to the return flow lines of the fuel assembly; and at least one outlet flow channel flow connected to the branch exit flow lines; and a flow port interposed between the penetration means and the distribution means for flow connecting the penetration means with the distribution means

  11. Exact solutions for a system of nonlinear plasma fluid equations

    International Nuclear Information System (INIS)

    Prahovic, M.G.; Hazeltine, R.D.; Morrison, P.J.

    1991-04-01

    A method is presented for constructing exact solutions to a system of nonlinear plasma fluid equations that combines the physics of reduced magnetohydrodynamics and the electrostatic drift-wave description of the Charney-Hasegawa-Mima equation. The system has nonlinearities that take the form of Poisson brackets involving the fluid field variables. The method relies on modifying a class of simple equilibrium solutions, but no approximations are made. A distinguishing feature is that the original nonlinear problem is reduced to the solution of two linear partial differential equations, one fourth-order and the other first-order. The first-order equation has Hamiltonian characteristics and is easily integrated, supplying information about the general structure of solutions. 6 refs

  12. Analysis of Direct Samples of Early Solar System Aqueous Fluids

    Science.gov (United States)

    Zolensky, Michael E.; Bodnar, R J.; Fedele, L.; Yurimoto,H.; Itoh, S.; Fries, M.; Steele, A.

    2012-01-01

    Over the past three decades we have become increasingly aware of the fundamental importance of water, and aqueous alteration, on primitive solar-system bodies. Some carbonaceous and ordinary chondrites have been altered by interactions with liquid water within the first 10 million years after formation of their parent asteroids. Millimeter to centimeter-sized aggregates of purple halite containing aqueous fluid inclusions were found in the matrix of two freshly-fallen brecciated H chondrite falls, Monahans (1998, hereafter simply "Monahans") (H5) and Zag (H3-6) (Zolensky et al., 1999; Whitby et al., 2000; Bogard et al., 2001) In order to understand origin and evolution of the aqueous fluids inside these inclusions we much measure the actual fluid composition, and also learn the O and H isotopic composition of the water. It has taken a decade for laboratory analytical techniques to catch up to these particular nanomole-sized aqueous samples. We have recently been successful in (1) measuring the isotopic composition of H and O in the water in a few fluid inclusions from the Zag and Monahans halite, (2) mineralogical characterization of the solid mineral phases associated with the aqueous fluids within the halite, and (3) the first minor element analyses of the fluid itself. A Cameca ims-1270 equipped with a cryo-sample-stage of Hokkaido University was specially prepared for the O and H isotopic measurements. The cryo-sample-stage (Techno. I. S. Corp.) was cooled down to c.a. -190 C using liquid nitrogen at which the aqueous fluid in inclusions was frozen. We excavated the salt crystal surfaces to expose the frozen fluids using a 15 keV Cs+ beam and measured negative secondary ions. The secondary ions from deep craters of approximately 10 m in depth emitted stably but the intensities changed gradually during measurement cycles because of shifting states of charge compensation, resulting in rather poor reproducibility of multiple measurements of standard fluid

  13. Interpretation of Fermion system equilibration by energy fluid motion

    International Nuclear Information System (INIS)

    Jang, S.

    1990-01-01

    We study the equilibration of fermion system with the help of both linear and non-linear master equations which are originated from the extended time-dependent Hartree-Fock equation of motion. We show how the non-linear master equation for nucleon occupation number transforms into the Navier-Stokes type of one dimensional equation for non-stationary flow of a compressible and viscous fluid. Physical consequences of these equations are investigated by providing illustrative examples

  14. Heat transfer and fluid flow in nuclear systems

    CERN Document Server

    Fenech, Henri

    1982-01-01

    Heat Transfer and Fluid in Flow Nuclear Systems discusses topics that bridge the gap between the fundamental principles and the designed practices. The book is comprised of six chapters that cover analysis of the predicting thermal-hydraulics performance of large nuclear reactors and associated heat-exchangers or steam generators of various nuclear systems. Chapter 1 tackles the general considerations on thermal design and performance requirements of nuclear reactor cores. The second chapter deals with pressurized subcooled light water systems, and the third chapter covers boiling water reacto

  15. 21 CFR 882.5550 - Central nervous system fluid shunt and components.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Central nervous system fluid shunt and components... Central nervous system fluid shunt and components. (a) Identification. A central nervous system fluid... central nervous system to an internal delivery site or an external receptacle for the purpose of relieving...

  16. Network Flow Simulation of Fluid Transients in Rocket Propulsion Systems

    Science.gov (United States)

    Bandyopadhyay, Alak; Hamill, Brian; Ramachandran, Narayanan; Majumdar, Alok

    2011-01-01

    Fluid transients, also known as water hammer, can have a significant impact on the design and operation of both spacecraft and launch vehicle propulsion systems. These transients often occur at system activation and shutdown. The pressure rise due to sudden opening and closing of valves of propulsion feed lines can cause serious damage during activation and shutdown of propulsion systems. During activation (valve opening) and shutdown (valve closing), pressure surges must be predicted accurately to ensure structural integrity of the propulsion system fluid network. In the current work, a network flow simulation software (Generalized Fluid System Simulation Program) based on Finite Volume Method has been used to predict the pressure surges in the feed line due to both valve closing and valve opening using two separate geometrical configurations. The valve opening pressure surge results are compared with experimental data available in the literature and the numerical results compared very well within reasonable accuracy (< 5%) for a wide range of inlet-to-initial pressure ratios. A Fast Fourier Transform is preformed on the pressure oscillations to predict the various modal frequencies of the pressure wave. The shutdown problem, i.e. valve closing problem, the simulation results are compared with the results of Method of Characteristics. Most rocket engines experience a longitudinal acceleration, known as "pogo" during the later stage of engine burn. In the shutdown example problem, an accumulator has been used in the feed system to demonstrate the "pogo" mitigation effects in the feed system of propellant. The simulation results using GFSSP compared very well with the results of Method of Characteristics.

  17. Computational Fluid Dynamics Analysis of an Evaporative Cooling System

    Directory of Open Access Journals (Sweden)

    Kapilan N.

    2016-11-01

    Full Text Available The use of chlorofluorocarbon based refrigerants in the air-conditioning system increases the global warming and causes the climate change. The climate change is expected to present a number of challenges for the built environment and an evaporative cooling system is one of the simplest and environmentally friendly cooling system. The evaporative cooling system is most widely used in summer and in rural and urban areas of India for human comfort. In evaporative cooling system, the addition of water into air reduces the temperature of the air as the energy needed to evaporate the water is taken from the air. Computational fluid dynamics is a numerical analysis and was used to analyse the evaporative cooling system. The CFD results are matches with the experimental results.

  18. Liquid Cooling System for CPU by Electroconjugate Fluid

    Directory of Open Access Journals (Sweden)

    Yasuo Sakurai

    2014-06-01

    Full Text Available The dissipated power of CPU for personal computer has been increased because the performance of personal computer becomes higher. Therefore, a liquid cooling system has been employed in some personal computers in order to improve their cooling performance. Electroconjugate fluid (ECF is one of the functional fluids. ECF has a remarkable property that a strong jet flow is generated between electrodes when a high voltage is applied to ECF through the electrodes. By using this strong jet flow, an ECF-pump with simple structure, no sliding portion, no noise, and no vibration seems to be able to be developed. And then, by the use of the ECF-pump, a new liquid cooling system by ECF seems to be realized. In this study, to realize this system, an ECF-pump is proposed and fabricated to investigate the basic characteristics of the ECF-pump experimentally. Next, by utilizing the ECF-pump, a model of a liquid cooling system by ECF is manufactured and some experiments are carried out to investigate the performance of this system. As a result, by using this system, the temperature of heat source of 50 W is kept at 60°C or less. In general, CPU is usually used at this temperature or less.

  19. Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors

    Science.gov (United States)

    Lin, Shing-Hong; Cheng, Yuan-Ren; Banks, Robert W.; Min, Ming-Yuan; Bewick, Guy S.; Chen, Chih-Cheng

    2016-01-01

    Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and subsequent characterization of heterogeneous expression of ASIC3 in the dorsal root ganglion (DRG). ASIC3 is expressed in parvalbumin (Pv+) proprioceptor axons innervating muscle spindles. We further generate a floxed allele of Asic3 (Asic3f/f) and probe the role of ASIC3 in mechanotransduction in neurite-bearing Pv+ DRG neurons through localized elastic matrix movements and electrophysiology. Targeted knockout of Asic3 disrupts spindle afferent sensitivity to dynamic stimuli and impairs mechanotransduction in Pv+ DRG neurons because of substrate deformation-induced neurite stretching, but not to direct neurite indentation. In behavioural tasks, global knockout (Asic3−/−) and Pv-Cre::Asic3f/f mice produce similar deficits in grid and balance beam walking tasks. We conclude that, at least in mouse, ASIC3 is a molecular determinant contributing to dynamic mechanosensitivity in proprioceptors. PMID:27161260

  20. Roles of the cytoskeleton, cell adhesion and rho signalling in mechanosensing and mechanotransduction.

    Science.gov (United States)

    Ohashi, Kazumasa; Fujiwara, Sachiko; Mizuno, Kensaku

    2017-03-01

    All cells sense and respond to various mechanical forces in and mechanical properties of their environment. To respond appropriately, cells must be able to sense the location, direction, strength and duration of these forces. Recent progress in mechanobiology has provided a better understanding of the mechanisms of mechanoresponses underlying many cellular and developmental processes. Various roles of mechanoresponses in development and tissue homeostasis have been elucidated, and many molecules involved in mechanotransduction have been identified. However, the whole picture of the functions and molecular mechanisms of mechanotransduction remains to be understood. Recently, novel mechanisms for sensing and transducing mechanical stresses via the cytoskeleton, cell-substrate and cell-cell adhesions and related proteins have been identified. In this review, we outline the roles of the cytoskeleton, cell-substrate and cell-cell adhesions, and related proteins in mechanosensing and mechanotransduction. We also describe the roles and regulation of Rho-family GTPases in mechanoresponses. © The Authors 2017. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

  1. An intelligent data acquisition system for fluid mechanics research

    Science.gov (United States)

    Cantwell, E. R.; Zilliac, G.; Fukunishi, Y.

    1989-01-01

    This paper describes a novel data acquisition system for use with wind-tunnel probe-based measurements, which incorporates a degree of specific fluid dynamics knowledge into a simple expert system-like control program. The concept was developed with a rudimentary expert system coupled to a probe positioning mechanism operating in a small-scale research wind tunnel. The software consisted of two basic elements, a general-purpose data acquisition system and the rulebased control element to take and analyze data and supplying decisions as to where to measure, how many data points to take, and when to stop. The system was validated in an experiment involving a vortical flow field, showing that it was possible to increase the resolution of the experiment or, alternatively, reduce the total number of data points required, to achieve parity with the results of most conventional data acquisition approaches.

  2. 21 CFR 862.1455 - Lecithin/sphingomyelin ratio in amniotic fluid test system.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Lecithin/sphingomyelin ratio in amniotic fluid... Clinical Chemistry Test Systems § 862.1455 Lecithin/sphingomyelin ratio in amniotic fluid test system. (a) Identification. A lecithin/sphingomyelin ratio in amniotic fluid test system is a device intended to measure the...

  3. Modeling interfacial area transport in multi-fluid systems

    Energy Technology Data Exchange (ETDEWEB)

    Yarbro, Stephen Lee [Univ. of California, Berkeley, CA (United States)

    1996-11-01

    Many typical chemical engineering operations are multi-fluid systems. They are carried out in distillation columns (vapor/liquid), liquid-liquid contactors (liquid/liquid) and other similar devices. An important parameter is interfacial area concentration, which determines the rate of interfluid heat, mass and momentum transfer and ultimately, the overall performance of the equipment. In many cases, the models for determining interfacial area concentration are empirical and can only describe the cases for which there is experimental data. In an effort to understand multiphase reactors and the mixing process better, a multi-fluid model has been developed as part of a research effort to calculate interfacial area transport in several different types of in-line static mixers. For this work, the ensemble-averaged property conservation equations have been derived for each fluid and for the mixture. These equations were then combined to derive a transport equation for the interfacial area concentration. The final, one-dimensional model was compared to interfacial area concentration data from two sizes of Kenics in-line mixer, two sizes of concurrent jet and a Tee mixer. In all cases, the calculated and experimental data compared well with the highest scatter being with the Tee mixer comparison.

  4. Conceptual design of intravenous fluids level monitoring system - a review

    Science.gov (United States)

    Verma, Prikshit; Padmani, Aniket; Boopathi, M.

    2017-11-01

    In today’s world of automation, there are advancements going on in all the fields. Each work is being automated day by day. However, if we see our current medical care system, some areas require manual caretaker and are loaded with heavy jobs, which consumes a lot of time. Nevertheless, since the work is related to human health, it should be properly done and that too with accuracy. An example of such a particular work is injecting saline or Intravenous (IV) fluids in a patient. The monitoring of such fluids needs utter attention as if the bottle of the fluid is not changed on time, it may lead to various problems for the patients like backflow of blood, blood loss etc. Various researches have been performed to overcome such critical situation. Different monitoring and alerting techniques are described in different researches. So, in our study, we will go through the researches done in this particular field and will see how different ideas are implemented.

  5. Multi-parameter monitoring system for hydraulic fluids; Multi-Parameter Monitoring System fuer Hydraulische Fluessigkeiten

    Energy Technology Data Exchange (ETDEWEB)

    Paul, Sumit; Legner, Wolfgang; Hackner, Angelika; Mueller, Gerhard [EADS Innovation Works, Muenchen (Germany). Bereich Sensors, Electronics and Systems Integration; Baumbach, Volker [Airbus Operations GmbH, Bremen (Germany). Bereich Hydraulic Performance and Integrity

    2011-07-01

    A miniaturised sensor system for aviation hydraulic fluids is presented. The system consists of an optochemical sensor and a particle sensor. The optochemical sensor detects the form of the O-H absorption feature around 3500 cm{sup -1} to reveal the water and acid contamination in the fluid. The particle sensor uses a light barrier principle to derive its particle contamination number. (orig.)

  6. Computational transport phenomena of fluid-particle systems

    CERN Document Server

    Arastoopour, Hamid; Abbasi, Emad

    2017-01-01

    This book concerns the most up-to-date advances in computational transport phenomena (CTP), an emerging tool for the design of gas-solid processes such as fluidized bed systems. The authors examine recent work in kinetic theory and CTP and illustrate gas-solid processes’ many applications in the energy, chemical, pharmaceutical, and food industries. They also discuss the kinetic theory approach in developing constitutive equations for gas-solid flow systems and how it has advanced over the last decade as well as the possibility of obtaining innovative designs for multiphase reactors, such as those needed to capture CO2 from flue gases. Suitable as a concise reference and a textbook supplement for graduate courses, Computational Transport Phenomena of Gas-Solid Systems is ideal for practitioners in industries involved with the design and operation of processes based on fluid/particle mixtures, such as the energy, chemicals, pharmaceuticals, and food processing. Explains how to couple the population balance e...

  7. Computational fluid dynamics (CFD) studies of a miniaturized dissolution system.

    Science.gov (United States)

    Frenning, G; Ahnfelt, E; Sjögren, E; Lennernäs, H

    2017-04-15

    Dissolution testing is an important tool that has applications ranging from fundamental studies of drug-release mechanisms to quality control of the final product. The rate of release of the drug from the delivery system is known to be affected by hydrodynamics. In this study we used computational fluid dynamics to simulate and investigate the hydrodynamics in a novel miniaturized dissolution method for parenteral formulations. The dissolution method is based on a rotating disc system and uses a rotating sample reservoir which is separated from the remaining dissolution medium by a nylon screen. Sample reservoirs of two sizes were investigated (SR6 and SR8) and the hydrodynamic studies were performed at rotation rates of 100, 200 and 400rpm. The overall fluid flow was similar for all investigated cases, with a lateral upward spiraling motion and central downward motion in the form of a vortex to and through the screen. The simulations indicated that the exchange of dissolution medium between the sample reservoir and the remaining release medium was rapid for typical screens, for which almost complete mixing would be expected to occur within less than one minute at 400rpm. The local hydrodynamic conditions in the sample reservoirs depended on their size; SR8 appeared to be relatively more affected than SR6 by the resistance to liquid flow resulting from the screen. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. An automated fluid-transport device for a microfluidic system.

    Science.gov (United States)

    Feng, Jun; Yang, Xiu-Juan; Li, Xin-Chun; Yang, Hui; Chen, Zuan-Guang

    2011-01-01

    An automated fluid-transport device for a chip-based capillary electrophoresis system has been developed. The device mainly consists of six peristaltic micropumps, two vacuum micropumps, microvalves, multi-way joints, titanium tubes, and a macro-to-micro connector. Various solutions used for the cleaning and activation of chip channels, and electrophoresis separation, are allowed to automatically transport to chip reservoirs by the electric control module. The performance of the whole system was characterized by the analysis of fluorescein sodium using chip electrophoresis with LED-induced fluorescence detection. The peak-height variation (RSD) was 3.8% in six cycles of analyses. Additionally, compared with conventional manual operation, the developed device can spare 60% time for chip pretreatment. This microdevice offers high-efficiency pretreatment for microchips, thereby resulting in a remarkable improvement of analytical capacity for batch samples.

  9. Application of ADINA fluid element for transient response analysis of fluid-structure system

    International Nuclear Information System (INIS)

    Sakurai, Y.; Kodama, T.; Shiraishi, T.

    1985-01-01

    Pressure propagation and Fluid-Structure Interaction (FSI) in 3D space were simulated by general purpose finite element program ADINA using the displacement-based fluid element which presumes inviscid and compressible fluid with no net flow. Numerical transient solution was compared with the measured data of an FSI experiment and was found to fairly agree with the measured. In the next step, post analysis was conducted for a blowdown experiment performed with a 1/7 scaled reactor pressure vessel and a flexible core barrel and the code performance was found to be satisfactory. It is concluded that the transient response of the core internal structure of a PWR during the initial stage of LOCA can be analyzed by the displacement-based finite fluid element and the structural element. (orig.)

  10. Therapeutic Options for Controlling Fluids in the Visual System

    Science.gov (United States)

    Curry, Kristina M.; Wotring, Virginia E.

    2014-01-01

    Visual Impairment/Intracranial Pressure (VIIP) is a newly recognized risk at NASA. The VIIP project examines the effect of long-term exposure to microgravity on vision of crewmembers before and after they return to Earth. Diamox (acetazolamide) is a medication which is used to decrease intraocular pressure; however, it carries a 3% risk of kidney stones. Astronauts are at a higher risk of kidney stones during spaceflight and the use Diamox would only increase the risk; therefore alternative therapies were investigated. Histamine 2 (H2) antagonist acid blockers such as cimetidine, ranitidine, famotidine and nizatidine are typically used to relieve the symptoms of gastroesophageal reflux disease (GERD). H2 receptors have been found in the human visual system, which has led to research on the use of H2 antagonist blockers to control fluid production in the human eye. Another potential therapeutic strategy is targeted at aquaporins, which are water channels that help maintain fluid homeostasis. Aquaporin antagonists are also known to affect intracranial pressure which can in turn alter intraocular pressure. Studies on aquaporin antagonists suggest high potential for effective treatment. The primary objective of this investigation is to review existing research on alternate medications or therapy to significantly reduce intracranial and intraocular pressure. A literature review was conducted. Even though we do not have all the answers quite yet, a considerable amount of information was discovered, and findings were narrowed, which should allow for more conclusive answers to be found in the near future.

  11. Endothelial Mechanotransduction, Redox Signaling and the Regulation of Vascular Inflammatory Pathways

    Directory of Open Access Journals (Sweden)

    Shampa Chatterjee

    2018-06-01

    Full Text Available The endothelium that lines the interior of blood vessels is directly exposed to blood flow. The shear stress arising from blood flow is “sensed” by the endothelium and is “transduced” into biochemical signals that eventually control vascular tone and homeostasis. Sensing and transduction of physical forces occur via signaling processes whereby the forces associated with blood flow are “sensed” by a mechanotransduction machinery comprising of several endothelial cell elements. Endothelial “sensing” involves converting the physical cues into cellular signaling events such as altered membrane potential and activation of kinases, which are “transmission” signals that cause oxidant production. Oxidants produced are the “transducers” of the mechanical signals? What is the function of these oxidants/redox signals? Extensive data from various studies indicate that redox signals initiate inflammation signaling pathways which in turn can compromise vascular health. Thus, inflammation, a major response to infection or endotoxins, can also be initiated by the endothelium in response to various flow patterns ranging from aberrant flow to alteration of flow such as cessation or sudden increase in blood flow. Indeed, our work has shown that endothelial mechanotransduction signaling pathways participate in generation of redox signals that affect the oxidant and inflammation status of cells. Our goal in this review article is to summarize the endothelial mechanotransduction pathways that are activated with stop of blood flow and with aberrant flow patterns; in doing so we focus on the complex link between mechanical forces and inflammation on the endothelium. Since this “inflammation susceptible” phenotype is emerging as a trigger for pathologies ranging from atherosclerosis to rejection post-organ transplant, an understanding of the endothelial machinery that triggers these processes is very crucial and timely.

  12. HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear.

    Directory of Open Access Journals (Sweden)

    Geoffrey C Horwitz

    Full Text Available The molecular composition of the hair cell transduction channel has not been identified. Here we explore the novel hypothesis that hair cell transduction channels include HCN subunits. The HCN family of ion channels includes four members, HCN1-4. They were originally identified as the molecular correlates of the hyperpolarization-activated, cyclic nucleotide gated ion channels that carry currents known as If, IQ or Ih. However, based on recent evidence it has been suggested that HCN subunits may also be components of the elusive hair cell transduction channel. To investigate this hypothesis we examined expression of mRNA that encodes HCN1-4 in sensory epithelia of the mouse inner ear, immunolocalization of HCN subunits 1, 2 and 4, uptake of the transduction channel permeable dye, FM1-43 and electrophysiological measurement of mechanotransduction current. Dye uptake and transduction current were assayed in cochlear and vestibular hair cells of wildtype mice exposed to HCN channel blockers or a dominant-negative form of HCN2 that contained a pore mutation and in mutant mice that lacked HCN1, HCN2 or both. We found robust expression of HCNs 1, 2 and 4 but little evidence that localized HCN subunits in hair bundles, the site of mechanotransduction. Although high concentrations of the HCN antagonist, ZD7288, blocked 50-70% of the transduction current, we found no reduction of transduction current in either cochlear or vestibular hair cells of HCN1- or HCN2- deficient mice relative to wild-type mice. Furthermore, mice that lacked both HCN1 and HCN2 also had normal transduction currents. Lastly, we found that mice exposed to the dominant-negative mutant form of HCN2 had normal transduction currents as well. Taken together, the evidence suggests that HCN subunits are not required for mechanotransduction in hair cells of the mouse inner ear.

  13. COTHERM: Modelling fluid-rock interactions in Icelandic geothermal systems

    Science.gov (United States)

    Thien, Bruno; Kosakowski, Georg; Kulik, Dmitrii

    2014-05-01

    Mineralogical alteration of reservoir rocks, driven by fluid circulation in natural or enhanced geothermal systems, is likely to influence the long-term performance of geothermal power generation. A key factor is the change of porosity due to dissolution of primary minerals and precipitation of secondary phases. Porosity changes will affect fluid circulation and solute transport, which, in turn, influence mineralogical alteration. This study is part of the Sinergia COTHERM project (COmbined hydrological, geochemical and geophysical modeling of geotTHERMal systems) that is an integrative research project aimed at improving our understanding of the sub-surface processes in magmatically-driven natural geothermal systems. We model the mineralogical and porosity evolution of Icelandic geothermal systems with 1D and 2D reactive transport models. These geothermal systems are typically high enthalphy systems where a magmatic pluton is located at a few kilometers depth. The shallow plutons increase the geothermal gradient and trigger the circulation of hydrothermal waters with a steam cap forming at shallow depth. We investigate two contrasting geothermal systems: Krafla, for which the water recharge consists of meteoritic water; and Reykjanes, for which the water recharge mainly consists of seawater. The initial rock composition is a fresh basalt. We use the GEM-Selektor geochemical modeling package [1] for calculation of kinetically controlled mineral equilibria between the rock and the ingression water. We consider basalt minerals dissolution kinetics according to Palandri & Kharaka [2]. Reactive surface areas are assumed to be geometric surface areas, and are corrected using a spherical-particle surface/mass relationship. For secondary minerals, we consider the partial equilibrium assuming that the primary mineral dissolution is slow, and the secondary mineral precipitation is fast. Comparison of our modeling results with the mineralogical assemblages observed in the

  14. Safety System for Controlling Fluid Flow into a Suction Line

    Science.gov (United States)

    England, John Dwight (Inventor); Kelley, Anthony R. (Inventor); Cronise, Raymond J. (Inventor)

    2018-01-01

    A safety system includes a sleeve fitted within a pool's suction line at its inlet. The sleeve terminates with a plate that resides within the suction line. The plate has holes formed therethrough. A housing defining distinct channels is fitted in the sleeve so that the distinct channels lie within the sleeve. Each of the distinct channels has a first opening on one end thereof and a second opening on another end thereof. The second openings reside in the sleeve. The first openings are in fluid communication with the water in the pool, and are distributed around a periphery of an area of the housing that prevents coverage of all the first openings when a human interacts therewith. A first sensor is coupled to the sleeve to sense pressure therein, and a second pressure sensor is coupled to the plate to sense pressure in one of the plates' holes.

  15. EXPERIMENTAL BUBBLE FORMATION IN A LARGE SCALE SYSTEM FOR NEWTONIAN AND NONNEWTONIAN FLUIDS

    Energy Technology Data Exchange (ETDEWEB)

    Leishear, R; Michael Restivo, M

    2008-06-26

    The complexities of bubble formation in liquids increase as the system size increases, and a photographic study is presented here to provide some insight into the dynamics of bubble formation for large systems. Air was injected at the bottom of a 28 feet tall by 30 inch diameter column. Different fluids were subjected to different air flow rates at different fluid depths. The fluids were water and non-Newtonian, Bingham plastic fluids, which have yield stresses requiring an applied force to initiate movement, or shearing, of the fluid. Tests showed that bubble formation was significantly different in the two types of fluids. In water, a field of bubbles was formed, which consisted of numerous, distributed, 1/4 to 3/8 inch diameter bubbles. In the Bingham fluid, large bubbles of 6 to 12 inches in diameter were formed, which depended on the air flow rate. This paper provides comprehensive photographic results related to bubble formation in these fluids.

  16. Computational fluid dynamics for turbomachinery internal air systems.

    Science.gov (United States)

    Chew, John W; Hills, Nicholas J

    2007-10-15

    Considerable progress in development and application of computational fluid dynamics (CFD) for aeroengine internal flow systems has been made in recent years. CFD is regularly used in industry for assessment of air systems, and the performance of CFD for basic axisymmetric rotor/rotor and stator/rotor disc cavities with radial throughflow is largely understood and documented. Incorporation of three-dimensional geometrical features and calculation of unsteady flows are becoming commonplace. Automation of CFD, coupling with thermal models of the solid components, and extension of CFD models to include both air system and main gas path flows are current areas of development. CFD is also being used as a research tool to investigate a number of flow phenomena that are not yet fully understood. These include buoyancy-affected flows in rotating cavities, rim seal flows and mixed air/oil flows. Large eddy simulation has shown considerable promise for the buoyancy-driven flows and its use for air system flows is expected to expand in the future.

  17. Method and apparatus for continuous fluid leak monitoring and detection in analytical instruments and instrument systems

    Science.gov (United States)

    Weitz, Karl K [Pasco, WA; Moore, Ronald J [West Richland, WA

    2010-07-13

    A method and device are disclosed that provide for detection of fluid leaks in analytical instruments and instrument systems. The leak detection device includes a collection tube, a fluid absorbing material, and a circuit that electrically couples to an indicator device. When assembled, the leak detection device detects and monitors for fluid leaks, providing a preselected response in conjunction with the indicator device when contacted by a fluid.

  18. Fetal jaw movement affects Ihh signaling in mandibular condylar cartilage development: the possible role of Ihh as mechanotransduction mediator.

    Science.gov (United States)

    Jahan, Esrat; Matsumoto, Akihiro; Rafiq, Ashiq Mahmood; Hashimoto, Ryuju; Inoue, Takayuki; Udagawa, Jun; Sekine, Joji; Otani, Hiroki

    2014-10-01

    Jaw movement is an important mechanical factor for prenatal development of the condylar cartilage of mandible. Fetal jaw movement restriction has been shown to cause deformity of the mandibular condyle. We hypothesized that this treatment affects the expression of mechanosensitive molecules, namely Indian hedgehog (Ihh) and Parathyroid hormone related protein (PTHrP) in the condyle. We restrained jaw movement by suturing the jaw of E15.5 mouse embryos and allowed them to develop until E18.5 using exo utero system, and analyzed them by immunohistochemistry and in situ hybridization methods. Morphological, histomorphometric and immunohistochemical study showed that the mandibular condylar cartilage was reduced and deformed, the volume and total cell numbers in the condylar cartilage were also reduced, and number and/or distribution of 5-bromo-2'-deoxyuridine-positive cells, Ihh-positive cells in the mesenchymal and pre-hypertrophic zones were significantly and correspondingly decreased in the sutured group. Using in situ hybridization, reduced expression of Ihh, PTHrP and their related receptors were observed in condylar cartilage of the sutured embryos. Our results revealed that the altered mechanical stress induced by prenatal jaw movement restriction decreased proliferating cells, the amount of cartilage, and altered expression of the Ihh and PTHrP, suggesting that Ihh act as mechanotransduction mediators in the development of mandibular condylar cartilage. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. TMI-2 in-vessel hydraulic systems utilize high water and high boron content fluids

    International Nuclear Information System (INIS)

    Baston, V.F.; Hofstetter, K.J.; Hofman, L.A.; Gallagher, R.E.

    1987-01-01

    Choice of a hydraulic fluid for use in the Three Mile Island Unit 2 (TMI-2) reactor vessel defueling equipment required consideration of the following constraints for the hydraulic fluid given an accidental spill into the reactor coolant system (RCS). The TMI-2 RCS hydraulic fluid utilized in the hydraulic operations utilized a solution composition of 95 wt% water and 5 wt% of the above base fluid. The TMI-2 hydraulic system utilizes pressures up to 3500 psi. The selected hydraulic fluid has been in use since December 1986 with minimal operational difficulties

  20. The search for and analysis of direct samples of early Solar System aqueous fluids.

    Science.gov (United States)

    Zolensky, Michael E; Bodnar, Robert J; Yurimoto, Hisayoshi; Itoh, Shoichi; Fries, Marc; Steele, Andrew; Chan, Queenie H-S; Tsuchiyama, Akira; Kebukawa, Yoko; Ito, Motoo

    2017-05-28

    We describe the current state of the search for direct, surviving samples of early, inner Solar System fluids-fluid inclusions in meteorites. Meteoritic aqueous fluid inclusions are not rare, but they are very tiny and their characterization is at the state of the art for most analytical techniques. Meteoritic fluid inclusions offer us a unique opportunity to study early Solar System brines in the laboratory. Inclusion-by-inclusion analyses of the trapped fluids in carefully selected samples will, in the immediate future, provide us detailed information on the evolution of fluids as they interacted with anhydrous solid materials. Thus, real data can replace calculated fluid compositions in thermochemical calculations of the evolution of water and aqueous reactions in comets, asteroids, moons and the terrestrial planets.This article is part of the themed issue 'The origin, history and role of water in the evolution of the inner Solar System'. © 2017 The Author(s).

  1. The role of apical cell-cell junctions and associated cytoskeleton in mechanotransduction.

    Science.gov (United States)

    Sluysmans, Sophie; Vasileva, Ekaterina; Spadaro, Domenica; Shah, Jimit; Rouaud, Florian; Citi, Sandra

    2017-04-01

    Tissues of multicellular organisms are characterised by several types of specialised cell-cell junctions. In vertebrate epithelia and endothelia, tight and adherens junctions (AJ) play critical roles in barrier and adhesion functions, and are connected to the actin and microtubule cytoskeletons. The interaction between junctions and the cytoskeleton is crucial for tissue development and physiology, and is involved in the molecular mechanisms governing cell shape, motility, growth and signalling. The machineries which functionally connect tight and AJ to the cytoskeleton comprise proteins which either bind directly to cytoskeletal filaments, or function as adaptors for regulators of the assembly and function of the cytoskeleton. In the last two decades, specific cytoskeleton-associated junctional molecules have been implicated in mechanotransduction, revealing the existence of multimolecular complexes that can sense mechanical cues and translate them into adaptation to tensile forces and biochemical signals. Here, we summarise the current knowledge about the machineries that link tight and AJ to actin filaments and microtubules, and the molecular basis for mechanotransduction at epithelial and endothelial AJ. © 2017 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.

  2. Heat transfer and fluid flow in nuclear systems

    International Nuclear Information System (INIS)

    Fenech, H.

    1981-01-01

    The present publication is an attempt to provide a bridge between fundamental principles and current design practice. It is intended to serve the need of: engineers, scientists and graduate students active in thermal and hydraulics problems and to those interested to keep abreast of the field. The text is addressed to readers with previous knowledge in heat transfer and fluid flow equvalent to a one year university graduate course in that field. Because of the high degree of specialization covered in the six chapters of the book, individual authors of international reputation and active in their respective area of specialization were selected to contribute their knowledge. Each of the six chapters or sub-chapters are self-contained. They are followed by problem sets to enable the reader to check his level of comprehension of the material presented. The nuclear systems covered in separate chapters include: the pressurized and boiling water reactors (PWR, BWR), the helium cooled high temperature reactors (HTGR and HTR), the breeders helium cooled (GCFR) and sodium cooled (LMFBR). In addition the heat-exchangers and steam generators commonly associated with the above systems are covered in Chapter 6

  3. Lagrange formalism for a system of several fluids interacting electromagnetically; Formalisme lagrangien pour un systeme de plusieurs fluides en interaction electromagnetique

    Energy Technology Data Exchange (ETDEWEB)

    Vuillemin, M [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-07-01

    After giving the Lagrange expression for a conducting fluid in an external electromagnetic field, the author shows that a Lagrange expression exists for describing the evolution of a system of interacting fluids obtained by adding the Lagrange expression of each fluid.to that of the electromagnetic field. By variation are obtained the fluid movement equation coupled to the Maxwell equations. It is shown that the study of small movements around a stationary state can be deduced from the Lagrange equation expanded to the second power order of the perturbation. It is then possible to deduce the normal mode equations and the study the stability by examining the modes which are marginally stable. (author) [French] Apres avoir rappele l'expression, du Lagrangien pour un fluide conducteur dans un champ electromagnetique exterieur, on montre qu'il existe un Lagrangien pour decrire l'evolution d'un systeme de fluides en.interaction que l'on obtient par la superposition du Lagrangien de chaque fluide et du Lagrangien du champ electromagnetique. On obtient par variation, les equations du mouvement des fluides, couplees aux equations de Maxwell. On montre que l'etude des petits mouvements autour d'un etat stationnaire se deduit du Lagrangien developpe au second1 ordre en puissance de la perturbation. On peut alors retrouver les equations des modes normaux et etudier la stabilite en recherchant les modes marginalement stables. (auteur)

  4. A fully continuous supercritical fluid extraction system for contaminated soil

    International Nuclear Information System (INIS)

    Ryan, M.; Stiver, W.H.

    2007-01-01

    Brownfield sites are contaminated sites in an urban setting. There are hundreds of thousands of such sites, where contaminants migrate to the atmosphere, seep into groundwater, runoff into surface water and enter the food chain through plant uptake and soil ingestion. The Sydney Tar Ponds alone contain more than a million tonnes of contaminated soils and sediments. Soil vapour extraction, incineration, bioremediation, solvent extraction and land filling are among the remediation techniques that have been developed for brownfield sites over the years. However, no single technology is ideally suited to all cases because of the diversity of contaminants and diversity of site characterization. This paper focused on supercritical fluid extraction (SFE) which is well suited to sites contaminated with polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and heavy metal. A fully continuous laboratory-scale SFE process for a slurry-based system was designed and constructed to handle the supercritical carbon dioxide (SC-CO 2 ) and the soil slurry. The system continuously pumps carbon dioxide under supercritical conditions and soil slurry into a counter-current contacting column. The testing soil was Delhi loamy sand, spiked with 10 mg/g of naphthalene. The soil slurry ranged from 0.0028 g dry soil per g slurry to 0.072 g/g. The operating temperature was 43 degrees C and the operating pressure was 7.7 MPa. Near steady state, fully continuous flow was achieved with runs lasting up to 2 hours. The quantifiable recoveries of naphthalene from the soil slurry was demonstrated and the mass transfer coefficients for the system were quantified in order to provide the foundation to advance to a full-scale system and costing analysis. 14 refs., 1 tab., 3 figs

  5. A fully continuous supercritical fluid extraction system for contaminated soil

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, M.; Stiver, W.H. [Guelph Univ., ON (Canada). School of Engineering

    2007-04-15

    Brownfield sites are contaminated sites in an urban setting. There are hundreds of thousands of such sites, where contaminants migrate to the atmosphere, seep into groundwater, runoff into surface water and enter the food chain through plant uptake and soil ingestion. The Sydney Tar Ponds alone contain more than a million tonnes of contaminated soils and sediments. Soil vapour extraction, incineration, bioremediation, solvent extraction and land filling are among the remediation techniques that have been developed for brownfield sites over the years. However, no single technology is ideally suited to all cases because of the diversity of contaminants and diversity of site characterization. This paper focused on supercritical fluid extraction (SFE) which is well suited to sites contaminated with polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and heavy metal. A fully continuous laboratory-scale SFE process for a slurry-based system was designed and constructed to handle the supercritical carbon dioxide (SC-CO{sub 2}) and the soil slurry. The system continuously pumps carbon dioxide under supercritical conditions and soil slurry into a counter-current contacting column. The testing soil was Delhi loamy sand, spiked with 10 mg/g of naphthalene. The soil slurry ranged from 0.0028 g dry soil per g slurry to 0.072 g/g. The operating temperature was 43 degrees C and the operating pressure was 7.7 MPa. Near steady state, fully continuous flow was achieved with runs lasting up to 2 hours. The quantifiable recoveries of naphthalene from the soil slurry was demonstrated and the mass transfer coefficients for the system were quantified in order to provide the foundation to advance to a full-scale system and costing analysis. 14 refs., 1 tab., 3 figs.

  6. System and method for improving performance of a fluid sensor for an internal combustion engine

    Science.gov (United States)

    Kubinski, David [Canton, MI; Zawacki, Garry [Livonia, MI

    2009-03-03

    A system and method for improving sensor performance of an on-board vehicle sensor, such as an exhaust gas sensor, while sensing a predetermined substance in a fluid flowing through a pipe include a structure for extending into the pipe and having at least one inlet for receiving fluid flowing through the pipe and at least one outlet generally opposite the at least one inlet, wherein the structure redirects substantially all fluid flowing from the at least one inlet to the sensor to provide a representative sample of the fluid to the sensor before returning the fluid through the at least one outlet.

  7. Fluid bed dryer and Aeropep solidification system. Amendment 1 to topical report

    International Nuclear Information System (INIS)

    1975-01-01

    Information is presented on interfaces between the aerojet fluid bed dryer and the liquid radwaste system, plant ventilation system, and radioactive solid waste handling system for BWR and PWR type reactors. (U.S.)

  8. Turbine airfoil cooling system with cooling systems using high and low pressure cooling fluids

    Science.gov (United States)

    Marsh, Jan H.; Messmann, Stephen John; Scribner, Carmen Andrew

    2017-10-25

    A turbine airfoil cooling system including a low pressure cooling system and a high pressure cooling system for a turbine airfoil of a gas turbine engine is disclosed. In at least one embodiment, the low pressure cooling system may be an ambient air cooling system, and the high pressure cooling system may be a compressor bleed air cooling system. In at least one embodiment, the compressor bleed air cooling system in communication with a high pressure subsystem that may be a snubber cooling system positioned within a snubber. A delivery system including a movable air supply tube may be used to separate the low and high pressure cooling subsystems. The delivery system may enable high pressure cooling air to be passed to the snubber cooling system separate from low pressure cooling fluid supplied by the low pressure cooling system to other portions of the turbine airfoil cooling system.

  9. Toward multiscale modelings of grain-fluid systems

    Science.gov (United States)

    Chareyre, Bruno; Yuan, Chao; Montella, Eduard P.; Salager, Simon

    2017-06-01

    Computationally efficient methods have been developed for simulating partially saturated granular materials in the pendular regime. In contrast, one hardly avoid expensive direct resolutions of 2-phase fluid dynamics problem for mixed pendular-funicular situations or even saturated regimes. Following previous developments for single-phase flow, a pore-network approach of the coupling problems is described. The geometry and movements of phases and interfaces are described on the basis of a tetrahedrization of the pore space, introducing elementary objects such as bridge, meniscus, pore body and pore throat, together with local rules of evolution. As firmly established local rules are still missing on some aspects (entry capillary pressure and pore-scale pressure-saturation relations, forces on the grains, or kinetics of transfers in mixed situations) a multi-scale numerical framework is introduced, enhancing the pore-network approach with the help of direct simulations. Small subsets of a granular system are extracted, in which multiphase scenario are solved using the Lattice-Boltzman method (LBM). In turns, a global problem is assembled and solved at the network scale, as illustrated by a simulated primary drainage.

  10. A new converter for improving efficiency of multi-actuators fluid power system

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Yong; Shang, JianZhong; Yang, JunHong; Wang Zhuo [National University of Defense Technology, Changsha (China)

    2016-05-15

    This paper is concerned with the application of energy efficient fluid power in mobile robots system and proposes a new fluid power converter system which is analogous to a boost converter in power electronics. The fluid power converter system is based on the principle of pulse-width modulation. The fluid power converter has an effect akin to an electrical switched inductance transformer, wherein the output pressure or flow rate can be stepped up or down. Using an inductive reactance device (an inertia mass-block), the output flow and pressure can be varied to meet the load by a means that does not rely on dissipation of power (the resistance control). The simulation model based on the mathematics models of the components is built to analyse the performance of the fluid power converter. It is clearly shown that the fluid power converter has higher energy efficiency than conventional resistance control manners.

  11. Theoretical aspects concerning working fluids in hydraulic systems

    Directory of Open Access Journals (Sweden)

    Tița Irina

    2017-01-01

    Full Text Available Among the properties of working fluid, viscosity is the most important as it regards especially to pumps. In order to study the behavior of hydrostatic transmission it is important to create a reliable research instrument for dynamic simulation. Our research expertise being in SimHydraulics consequently this instrument is the suitable block diagram. The purpose of this paper is to present the possible ways to customize the properties of the working fluid in the block diagram.

  12. Contamination Control and Monitoring of Tap Water as Fluid in Industrial Tap Water Hydraulic Systems

    DEFF Research Database (Denmark)

    Conrad, Finn; Adelstorp, Anders

    1998-01-01

    Presentation of results and methods addressed to contamination control and monitoring of tap water as fluid in tap water hydraulic systems.......Presentation of results and methods addressed to contamination control and monitoring of tap water as fluid in tap water hydraulic systems....

  13. Multi-scale and multi-physics model of the uterine smooth muscle with mechanotransduction.

    Science.gov (United States)

    Yochum, Maxime; Laforêt, Jérémy; Marque, Catherine

    2018-02-01

    Preterm labor is an important public health problem. However, the efficiency of the uterine muscle during labor is complex and still poorly understood. This work is a first step towards a model of the uterine muscle, including its electrical and mechanical components, to reach a better understanding of the uterus synchronization. This model is proposed to investigate, by simulation, the possible role of mechanotransduction for the global synchronization of the uterus. The electrical diffusion indeed explains the local propagation of contractile activity, while the tissue stretching may play a role in the synchronization of distant parts of the uterine muscle. This work proposes a multi-physics (electrical, mechanical) and multi-scales (cell, tissue, whole uterus) model, which is applied to a realistic uterus 3D mesh. This model includes electrical components at different scales: generation of action potentials at the cell level, electrical diffusion at the tissue level. It then links these electrical events to the mechanical behavior, at the cellular level (via the intracellular calcium concentration), by simulating the force generated by each active cell. It thus computes an estimation of the intra uterine pressure (IUP) by integrating the forces generated by each active cell at the whole uterine level, as well as the stretching of the tissue (by using a viscoelastic law for the behavior of the tissue). It finally includes at the cellular level stretch activated channels (SACs) that permit to create a loop between the mechanical and the electrical behavior (mechanotransduction). The simulation of different activated regions of the uterus, which in this first "proof of concept" case are electrically isolated, permits the activation of inactive regions through the stretching (induced by the electrically active regions) computed at the whole organ scale. This permits us to evidence the role of the mechanotransduction in the global synchronization of the uterus. The

  14. Superfluid {sup 3}He, a two-fluid system, with the normal-fluid dynamics dominated by Andreev reflection

    Energy Technology Data Exchange (ETDEWEB)

    Pickett, G. R., E-mail: g.pickett@lancaster.ac.uk [Lancaster University, Department of Physics (United Kingdom)

    2014-12-15

    As a specific offering towards his festschrift, we present a review the various properties of the excitation gas in superfluid {sup 3}He, which depend on Andreev reflection. This phenomenon dominates many of the properties of the normal fluid, especially at the lowest temperatures. We outline the ideas behind this dominance and describe a sample of the many experiments in this system which the operation of Andreev reflection has made possible, from temperature measurement, particle detection, vortex imaging to cosmological analogues.

  15. Aquifer restoration system improvement using an acid fluid purge

    International Nuclear Information System (INIS)

    Hodder, E.A.; Peck, C.A.

    1992-01-01

    The implementation of a water pump acid purge procedure at a free-phase liquid hydrocarbon recovery site has increased water pump operational run times and improved the effectiveness of the aquifer restoration effort. Before introduction of this technique, pumps at some locations would fail within 14 days of operation due to CaSO 4 .2H 2 O (calcium sulfate) precipitate fouling. After acid purge implementation at these locations, pump operational life improved to an average of over 110 days. Other locations, where pump failures would occur within one month, were improved to approximately six months of operation. The increase in water pump run time has also improved the liquid hydrocarbon recovery rate by 2,000 gallons per day; representing a 20% increase for the aquifer restoration system. Other concepts tested in attempts to prolong pump life included: specially designed electric submersible pumps, submersible pump shrouds intended to reduce the fluid pressure shear that enhances CaSO 4 .2H 2 O precipitation, and high volume pneumatic gas lift pumps. Due to marginal pump life improvement or other undesirable operational features, these concepts were primarily ineffective. The purge apparatus utilizes an acid pump, hose, and discharge piping to deliver the solution directly into the inlet of an operating water pump. The water pumps used for this activity require stainless steel construction with Teflon or other acid resistant bearings and seals. Purges are typically conducted before sudden discharge pressure drops (greater than 15 psig) occur for the operating water pump. Depending on volume of precipitate accumulation and pump type, discharge pressure is restored after introduction of 10 to 40 gallons of hydrochloric acid solution. The acid purge procedure outlined herein eliminates operational downtime and does not require well head pump removal and the associated costs of industry cleaning procedures

  16. Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing

    OpenAIRE

    Trumper, David; Kassis, Timothy; Griffith, Linda; Noh, Minkyun; Soenksen, Luis

    2018-01-01

    Precise fluid height sensing in open-channel microfluidics has long been a desirable feature for a wide range of applications. However, performing accurate measurements of the fluid level in small-scale reservoirs (<1mL) has proven to be an elusive goal, especially if direct fluid-sensor contact needs to be avoided. In particular, gravity-driven systems used in several microfluidic applications to establish pressure gradients and impose flow remain open-loop and largely unmonitored due to ...

  17. Fluctuation-driven mechanotransduction regulates mitochondrial-network structure and function

    Science.gov (United States)

    Bartolák-Suki, Erzsébet; Imsirovic, Jasmin; Parameswaran, Harikrishnan; Wellman, Tyler J.; Martinez, Nuria; Allen, Philip G.; Frey, Urs; Suki, Béla

    2015-10-01

    Cells can be exposed to irregular mechanical fluctuations, such as those arising from changes in blood pressure. Here, we report that ATP production, assessed through changes in mitochondrial membrane potential, is downregulated in vascular smooth muscle cells in culture exposed to monotonous stretch cycles when compared with cells exposed to a variable cyclic stretch that incorporates physiological levels of cycle-by-cycle variability in stretch amplitude. Variable stretch enhances ATP production by increasing the expression of ATP synthase’s catalytic domain, cytochrome c oxidase and its tyrosine phosphorylation, mitofusins and PGC-1α. Such a fluctuation-driven mechanotransduction mechanism is mediated by motor proteins and by the enhancement of microtubule-, actin- and mitochondrial-network complexity. We also show that, in aorta rings isolated from rats, monotonous stretch downregulates--whereas variable stretch maintains--physiological vessel-wall contractility through mitochondrial ATP production. Our results have implications for ATP-dependent and mechanosensitive intracellular processes.

  18. Multi-fluid renewable geo-energy systems and methods

    Science.gov (United States)

    Buscheck, Thomas A.

    2017-08-22

    A geo-energy production method for extracting thermal energy from a reservoir formation. A production well extracts brine from the reservoir formation. A plurality of working fluid injection ("WFI") wells may be arranged proximate to the production well to at least partially circumscribe the production well. A plurality of brine production ("BP") wells may be arranged in a vicinity of the WFI wells to at least partially circumscribe the WFI wells. A working fluid is injected into the WFI wells to help drive a flow of the brine up through the production and BP wells, together with at least a portion of the injected working fluid. Parasitic-load time-shifting and to storing of excess solar thermal energy may also be performed.

  19. SINDA/SINFLO computer routine, volume 1, revision A. [for fluid flow system analysis

    Science.gov (United States)

    Oren, J. A.; Williams, D. R.

    1975-01-01

    The SINFLO package was developed to modify the SINDA preprocessor to accept and store the input data for fluid flow systems analysis and adding the FLOSOL user subroutine to perform the flow solution. This reduced and simplified the user input required for analysis of flow problems. A temperature calculation method, the flow-hybrid method which was developed in previous VSD thermal simulator routines, was incorporated for calculating fluid temperatures. The calculation method accuracy was improved by using fluid enthalpy rather than specific heat for the convective term of the fluid temperature equation. Subroutines and data input requirements are described along with user subroutines, flow data storage, and usage of the plot program.

  20. Ore-forming fluid system of bauxite in WZD area of northern Guizhou province, China

    Science.gov (United States)

    Cui, Tao

    2017-12-01

    The ore-forming fluid system of bauxite in Wuchuan-Zheng,an-Daozhen (short for WZD) Area of northern Guizhou Province was studied from the perspective of deposit formation mechanism. It was discovered that ore-forming fluids were mainly effective for transporting and leaching during the formation of bauxite. The means of transport mainly included colloidal transport, suspended transport and gravity flow transport. In the course of their leaching, fluids had a range of chemical reactions, as a result of which elements such as silicon and iron migrated downwards. In this process, properties of fluids changed as well.

  1. Prospects of the use of nanofluids as working fluids for organic Rankine cycle power systems

    DEFF Research Database (Denmark)

    Mondejar, Maria E.; Andreasen, Jesper G.; Regidor, Maria

    2017-01-01

    The search of novel working fluids for organic Rankine cycle power systems is driven by the recent regulations imposing additional phase-out schedules for substances with adverse environmental characteristics. Recently, nanofluids (i.e. colloidal suspensions of nanoparticles in fluids) have been...... suggested as potential working fluids for organic Rankine cycle power systems due to their enhanced thermal properties, potentially giving advantages with respect to the design of the components and the cycle performance. Nevertheless, a number of challenges concerning the use of nanofluids must...... the prospects of using nanofluids as working fluids for organic Rankine cycle power systems. As a preliminary study, nanofluids consisting of a homogenous and stable mixture of different nanoparticles types and a selected organic fluid are simulated on a case study organic Rankine cycle unit for waste heat...

  2. Large eddy simulation on thermal fluid mixing in a T-junction piping system

    Energy Technology Data Exchange (ETDEWEB)

    Selvam, P. Karthick; Kulenovic, R.; Laurien, E. [Stuttgart Univ. (Germany). Inst fuer Kernenergie und Energiesysteme (IKE)

    2014-11-15

    High cycle thermal fatigue damage caused in piping systems is an important problem encountered in the context of nuclear safety and lifetime management of a Nuclear Power Plant (NPP). The T-junction piping system present in the Residual Heat Removal System (RHRS) is more vulnerable to thermal fatigue cracking. In this numerical study, thermal mixing of fluids at temperature difference (?T) of 117 K between the mixing fluids is analyzed. Large Eddy Simulation (LES) is performed with conjugate heat transfer between the fluid and structure. LES is performed based on the Fluid-Structure Interaction (FSI) test facility at University of Stuttgart. The results show an intense turbulent mixing of fluids downstream of T-junction. Amplitude of temperature fluctuations near the wall region and its corresponding frequency distribution is analyzed. LES is performed using commercial CFD software ANSYS CFX 14.0.

  3. Reducing Fatigue Loading Due to Pressure Shift in Discrete Fluid Power Force Systems

    DEFF Research Database (Denmark)

    Hansen, Anders Hedegaard; Pedersen, Henrik Clemmensen

    2016-01-01

    power force system. The current paper investigates the correlation between pressure oscillations in the cylinder chambers and valve flow in the manifold. Furthermore, the correlation between the pressure shifting time and the pressure overshoot is investigated. The study therefore focus on how to shape......Discrete Fluid Power Force Systems is one of the topologies gaining focus in the pursuit of lowering energy losses in fluid power transmission systems. The cylinder based Fluid Power Force System considered in this article is constructed with a multi-chamber cylinder, a number of constant pressure...... oscillations in the cylinder chamber, especially for systems with long connections between the cylinder and the valve manifold. Hose pressure oscillations will induce oscillations in the produced piston force. Hence, pressure oscillations may increase the fatigue loading on systems employing a discrete fluid...

  4. Preheating of fluid in a supercritical Brayton cycle power generation system at cold startup

    Science.gov (United States)

    Wright, Steven A.; Fuller, Robert L.

    2016-07-12

    Various technologies pertaining to causing fluid in a supercritical Brayton cycle power generation system to flow in a desired direction at cold startup of the system are described herein. A sensor is positioned at an inlet of a turbine, wherein the sensor is configured to output sensed temperatures of fluid at the inlet of the turbine. If the sensed temperature surpasses a predefined threshold, at least one operating parameter of the power generation system is altered.

  5. Instabilities in vertically vibrated fluid-grain systems.

    Science.gov (United States)

    King, P J; Lopez-Alcaraz, P; Pacheco-Martinez, H A; Clement, C P; Smith, A J; Swift, M R

    2007-03-01

    When a bed of fluid-immersed fine grains is exposed to vertical vibration a wealth of phenomena may be observed. At low frequencies a horizontal bed geometry is generally unstable and the bed breaks spatial symmetry, acquiring a tilt. At the same time it undergoes asymmetric granular convection. Fine binary mixtures may separate completely into layers or patterns of stripes. The separated regions may exhibit instabilities in which they undergo wave-like motion or exhibit quasi-periodic oscillations. We briefly review these and a number of related behaviours, identifying the physical mechanisms behind each. Finally, we discuss the magneto-vibratory separation of binary mixtures which results from exposing each component to a different effective gravity and describe the influence of a background fluid on this process.

  6. Acoustic Manipulation of Particles and Fluids in Microfluidic Systems

    OpenAIRE

    Johansson, Linda

    2009-01-01

    The downscaling and integration of biomedical analyses onto a single chip offers several advantages in speed, cost, parallelism and de-centralization. Acoustic radiation forces are attractive to use in these applications since they are strong, long-range and gentle. Lab-on-a-chip operations such as cell trapping, particle fluorescence activated cell sorting, fluid mixing and particle sorting performed by acoustic radiation forces are exploited in this thesis. Two different platforms are desig...

  7. Analysis and hazard evaluation of heat-transfer fluids for the direct contact cooling system

    International Nuclear Information System (INIS)

    Hong, Joo Hi; Lee, Yeon Hee; Shin, You Hwan; Karng, Sarng Woo; Kim, Seo Young; Kim, Young Gil

    2006-01-01

    This paper discusses several low-temperature heat-transfer fluids, including water-based inorganic salt, organic salt, alcohol/glycol mixtures, silicones, and halogenated hydrocarbons in order to choose the best heat-transfer fluid for the newly designed direct contact refrigeration system. So, it contains a survey on commercial products such as propylene glycol and potassium formate as newly used in super market and food processing refrigeration. The stability of commercial fluids at the working temperature of -20 .deg. C was monitored as a function of time up to two months. And organic and inorganic compositions of candidate fluids were obtained by analytical instruments such as ES, XRF, AAS, ICP-AES, GC, and GC-MS. Analysis results indicate that commercial propylene glycol is very efficient and safe heat transfer fluids for the direct cooling system with liquid phase

  8. Performance of the mineral blended ester oil-based drilling fluid systems

    Energy Technology Data Exchange (ETDEWEB)

    Ismail, A.R.; Kamis, A.; Foo, K.S. [University Teknologi (Malaysia)

    2001-06-01

    A study was conducted in which the properties of ester oil-based drilling fluid systems were examined using a blended mixture of ester and synthetic mineral oil. Biodegradable invert emulsion ester-based fluids are preferred over mineral oil-based drilling fluids for environmental reasons, but they tend to cause alkaline hydrolysis resulting in solidification of the drilling fluid systems. The drilling fluid examined here consisted of Malaysian palm oil ester derivatives (methyl laureate ester or isopropyl laureate ester) blended with commercially available synthetic mineral oil. This mineral oil was added to reduce the problem of alkaline hydrolysis. This mixture, however, was found to be unstable and could not solve the problem at high temperature. The isopropyl laureate and mineral oil blended system was more stable towards the hydrolysis process up to 250 degrees F. In order to enhance the performance of an invert emulsion drilling fluid system, it was recommended that brine water content of the fluid system be lowered. 3 refs., 2 figs.

  9. Technology for Space Station Evolution. Volume 3: EVA/Manned Systems/Fluid Management System

    Science.gov (United States)

    1990-01-01

    NASA's Office of Aeronautics and Space Technology (OAST) conducted a workshop on technology for space station evolution 16-19 Jan. 1990 in Dallas, Texas. The purpose of this workshop was to collect and clarify Space Station Freedom technology requirements for evolution and to describe technologies that can potentially fill those requirements. These proceedings are organized into an Executive Summary and Overview and five volumes containing the Technology Discipline Presentations. Volume 3 consists of the technology discipline sections for Extravehicular Activity/Manned Systems and the Fluid Management System. For each technology discipline, there is a Level 3 subsystem description, along with the papers.

  10. Polydispersity effect on solid-fluid transition in hard sphere systems

    KAUST Repository

    Nogawa, T.; Watanabe, H.; Ito, N.

    2010-01-01

    The solid-fluid transition of the hard elastic particle system with size polydispersity is studied by molecular dynamics simulations. Using nonequilibrium relaxation from the mixed initial condition we determines the melting point where the first

  11. Integrated Reacting Fluid Dynamics and Predictive Materials Degradation Models for Propulsion System Conditions, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Computational fluid dynamics (CFD) simulations are routinely used by NASA to optimize the design of propulsion systems. Current methods for CFD modeling rely on...

  12. Finite Element Analysis of Fluid-Structure Interaction in a Blast-Resistant Window System (PREPRINT)

    National Research Council Canada - National Science Library

    Chung, Jae H; Consolazio, Gary R; Dinan, Robert J; Rinehart, Stephen A

    2008-01-01

    .... The influences of shock wave propagation and fluid venting inside the damping chamber of the flex-window system are quantified and the influences of such phenomena on panel deflections, deformations, and internal forces are presented.

  13. Breakdown of Preservative Fluid MIL-PRF-46170 in Aircraft Hydraulic Systems

    National Research Council Canada - National Science Library

    Moorman, Jeffrey

    2001-01-01

    .... Additional information obtained from outside sources is also summarized for background. Laboratory pump testing showed rapid filter dogging with small amounts of preservative fluid (MU-PRF-46l70) in the system...

  14. Magnetohydrodynamic pump with a system for promoting flow of fluid in one direction

    Science.gov (United States)

    Lemoff, Asuncion V [Union City, CA; Lee, Abraham P [Irvine, CA

    2010-07-13

    A magnetohydrodynamic pump for pumping a fluid. The pump includes a microfluidic channel for channeling the fluid, a MHD electrode/magnet system operatively connected to the microfluidic channel, and a system for promoting flow of the fluid in one direction in the microfluidic channel. The pump has uses in the medical and biotechnology industries for blood-cell-separation equipment, biochemical assays, chemical synthesis, genetic analysis, drug screening, an array of antigen-antibody reactions, combinatorial chemistry, drug testing, medical and biological diagnostics, and combinatorial chemistry. The pump also has uses in electrochromatography, surface micromachining, laser ablation, inkjet printers, and mechanical micromilling.

  15. Development and Implementation of a Design Metric for Systems Containing Long-Term Fluid Loops

    Science.gov (United States)

    Steele, John W.

    2016-01-01

    John Steele, a chemist and technical fellow from United Technologies Corporation, provided a water quality module to assist engineers and scientists with a metric tool to evaluate risks associated with the design of space systems with fluid loops. This design metric is a methodical, quantitative, lessons-learned based means to evaluate the robustness of a long-term fluid loop system design. The tool was developed by a cross-section of engineering disciplines who had decades of experience and problem resolution.

  16. Mathematical models of incompressible fluids as singular limits of complete fluid systems

    Czech Academy of Sciences Publication Activity Database

    Feireisl, Eduard

    2010-01-01

    Roč. 78, č. 2 (2010), s. 523-560 ISSN 1424-9286 R&D Projects: GA ČR GA201/08/0315 Institutional research plan: CEZ:AV0Z10190503 Keywords : scale analysis * Navier-Stokes-Fourier system * incompressible limit Subject RIV: BA - General Mathematics Impact factor: 0.933, year: 2010 http://link.springer.com/article/10.1007%2Fs00032-010-0128-1

  17. Numerical fluid flow and heat transfer calculations on multiprocessor systems

    Energy Technology Data Exchange (ETDEWEB)

    Oehman, G.A.; Malen, T.E.; Kuusela, P.

    1989-01-01

    The first part of the report presents the basic principles of parallel processing, and factors influencing tbe efficiency of practical applications are discussed. In a multiprocessor computer, different parts of the program code are executed in parallel, i.e. simultaneous with respect to time, on different processors, and thus it becomes possible to decrease the overall computation time by a factor, which in the ideal case is equal to the number of processors. The application study starts from the numerical solution of the twodimesional Laplace equation, which describes the steady heat conduction in a solid plate and advances through the solution of the three dimensional Laplace equation to the case of study laminar fluid flow in a twodimensional box at Reynolds numbers up to 20. Hereby the stream function-vorticity method is first applied and the SIMPLER method. The conventional (sequential) numerical algoritms for these fluid flow and heat transfer problems are found not to be ideally suited for conversion to parallel computation, but sped-up ratios considerably above 50 % of the theoretical maximum are regularly achieved in the runs. The numerical procedures we coded in the OCCAM-2 language and the test runs were performed at who Akademi on the imperimental HATHI-computers containing 16 T4l4 and 100 INMOS T800 transputers respectively.

  18. Numerical fluid flow and heat transfer calculations on multiprocessor systems

    Energy Technology Data Exchange (ETDEWEB)

    Oehman, G.A.; Malen, T.E.; Kuusela, P.

    1989-12-31

    The first part of the report presents the basic principles of parallel processing, and factors influencing tbe efficiency of practical applications are discussed. In a multiprocessor computer, different parts of the program code are executed in parallel, i.e. simultaneous with respect to time, on different processors, and thus it becomes possible to decrease the overall computation time by a factor, which in the ideal case is equal to the number of processors. The application study starts from the numerical solution of the twodimesional Laplace equation, which describes the steady heat conduction in a solid plate and advances through the solution of the three dimensional Laplace equation to the case of study laminar fluid flow in a twodimensional box at Reynolds numbers up to 20. Hereby the stream function-vorticity method is first applied and the SIMPLER method. The conventional (sequential) numerical algoritms for these fluid flow and heat transfer problems are found not to be ideally suited for conversion to parallel computation, but sped-up ratios considerably above 50 % of the theoretical maximum are regularly achieved in the runs. The numerical procedures we coded in the OCCAM-2 language and the test runs were performed at who Akademi on the imperimental HATHI-computers containing 16 T4l4 and 100 INMOS T800 transputers respectively.

  19. The antioxidant system of seminal fluid during in vitro storage of sterlet Acipenser ruthenus sperm.

    Science.gov (United States)

    Dzyuba, Viktoriya; Cosson, Jacky; Dzyuba, Borys; Yamaner, Gunes; Rodina, Marek; Linhart, Otomar

    2016-04-01

    The role of the seminal fluid antioxidant system in protection against damage to spermatozoa during in vitro sperm storage is unclear. This study investigated the effect of in vitro storage of sterlet Acipenser ruthenus spermatozoa together with seminal fluid for 36 h at 4 °C on spermatozoon motility rate and curvilinear velocity, thiobarbituric acid reactive substance level, and components of enzyme and non-enzyme antioxidant system (superoxide dismutase and catalase activity and uric acid concentration) in seminal fluid. Spermatozoon motility parameters after sperm storage were significantly decreased, while the level of thiobarbituric acid reactive substances, activity of superoxide dismutase and catalase, and uric acid concentration did not change. Our findings suggest that the antioxidant system of sterlet seminal fluid is effective in preventing oxidative stress during short-term sperm storage and prompt future investigations of changes in spermatozoon homeostasis and in spermatozoon plasma membrane structure which are other possible reasons of spermatozoon motility deterioration upon sperm storage.

  20. A Cryogenic Fluid System Simulation in Support of Integrated Systems Health Management

    Science.gov (United States)

    Barber, John P.; Johnston, Kyle B.; Daigle, Matthew

    2013-01-01

    Simulations serve as important tools throughout the design and operation of engineering systems. In the context of sys-tems health management, simulations serve many uses. For one, the underlying physical models can be used by model-based health management tools to develop diagnostic and prognostic models. These simulations should incorporate both nominal and faulty behavior with the ability to inject various faults into the system. Such simulations can there-fore be used for operator training, for both nominal and faulty situations, as well as for developing and prototyping health management algorithms. In this paper, we describe a methodology for building such simulations. We discuss the design decisions and tools used to build a simulation of a cryogenic fluid test bed, and how it serves as a core technology for systems health management development and maturation.

  1. Working fluid charge oriented off-design modeling of a small scale Organic Rankine Cycle system

    International Nuclear Information System (INIS)

    Liu, Liuchen; Zhu, Tong; Ma, Jiacheng

    2017-01-01

    Highlights: • Organic Rankine Cycle model considering working fluid charge has been established. • Overall solution algorithm of system off-design performance is proposed. • Variation trend of different zones in both heat exchangers can be observed. • Optimal working fluid charge volume for different output work has been estimated. - Abstract: Organic Rankine Cycle system is one of the most widely used technique for low-grade waste heat recovery. Developing of dynamic Organic Rankine Cycle models played an increasingly important part in system performance prediction. The present paper developed a working fluid charge oriented model for an small scale Organic Rankine Cycle to calculate the theoretical value of working fluid charge level for the system under rated condition. The two heat exchangers are divided into three different zones and related heat transfer correlations are employed to estimate the length variation of each zones. Steady state models have been applied to describe the performance of pump and expander. Afterwards, an overall solution algorithm based on the established model has been proposed in order to exact simulate the system’s off-design performance. Additionally, the impact of different working fluid charge volumes has also been discussed. Simulation results clearly shows the variation trend of different zones in both heat exchangers, as well as the variation trend of system operating parameters under various expander output work. Furthermore, the highest thermal efficiency can be reached 6.37% under rated conditions with a working fluid charge volume of 34.6 kg.

  2. Considerable reduction of loads in piping systems after pump failure by coupled fluid/structure-calculation

    International Nuclear Information System (INIS)

    Schoenfelder, C.; Kellner, A.

    1985-01-01

    An approximated representative part of a PWR-feed-water-line was modelled and used to calculate the displacements of the piping system and the loads on it, caused by pressure pulse due to pump failure and subsequent check valve closure. The computation was performed with the code SAPHYR which contains the fluid code ROLAST and the structure code SAPIENS, calculating simultaneously and interactively. The results were compared with an uncoupled calculation without fluid/structure interaction. It was shown that neglecting the fluid/structure interaction can lead to considerable overestimations - in some cases up to a factor of 3 - of the loads on the structures. (orig.)

  3. Experimental evaluation of SWCNT-water nanofluid as a secondary fluid in a refrigeration system

    International Nuclear Information System (INIS)

    Vasconcelos, Adriano Akel; Cárdenas Gómez, Abdul Orlando; Bandarra Filho, Enio Pedone; Parise, José Alberto Reis

    2017-01-01

    Highlights: • SWCNT-water nanofluid was used as secondary fluid for a refrigeration system. • For a given HTFS mass flow rate and inlet temperature, nanofluid performed better than base fluid. • Total power consumption was not significantly affected by volume concentration. • Nanoparticle volume fraction ranged from 0 to 0.21%. - Abstract: SWCNT-water (single walled carbon nanotube) nanofluid was tested as a secondary fluid for a 4–9 kW indirect vapor compression refrigeration system. The evaporator, with boiling refrigerant HCFC-22 extracting heat from the nanofluid, was of the brazed plate counter-flow type. A semi-hermetic compressor, an electronic expansion valve (EEV) and an air-cooled condenser were the other main components of the refrigeration cycle. Tests were carried out with the experimental apparatus operating over a range of different volumetric fractions of nanoparticles (0–0.21%) as well as nanofluid inlet temperatures (30–40 °C) and mass flow rates (40–80 g/s). Overall, the performance of the system working with nanofluid as a secondary fluid was superior to that where just the base fluid (i.e., pure water) circulated in the secondary fluid loop, at the same mass flow rate and inlet temperature. The enhanced thermal conductivity of the nanofluid is believed to be the main reason why the refrigeration system with the nanofluid loop, if compared to that with pure water, presented a higher refrigerating capacity.

  4. Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing.

    Science.gov (United States)

    Soenksen, L R; Kassis, T; Noh, M; Griffith, L G; Trumper, D L

    2018-03-13

    Precise fluid height sensing in open-channel microfluidics has long been a desirable feature for a wide range of applications. However, performing accurate measurements of the fluid level in small-scale reservoirs (sensor contact needs to be avoided. In particular, gravity-driven systems used in several microfluidic applications to establish pressure gradients and impose flow remain open-loop and largely unmonitored due to these sensing limitations. Here we present an optimized self-shielded coplanar capacitive sensor design and automated control system to provide submillimeter fluid-height resolution (∼250 μm) and control of small-scale open reservoirs without the need for direct fluid contact. Results from testing and validation of our optimized sensor and system also suggest that accurate fluid height information can be used to robustly characterize, calibrate and dynamically control a range of microfluidic systems with complex pumping mechanisms, even in cell culture conditions. Capacitive sensing technology provides a scalable and cost-effective way to enable continuous monitoring and closed-loop feedback control of fluid volumes in small-scale gravity-dominated wells in a variety of microfluidic applications.

  5. Zyxin Is Involved In Regulation Of Mechanotransduction In Arteriole Smooth Muscle Cells

    Directory of Open Access Journals (Sweden)

    Zhe eSun

    2012-12-01

    Full Text Available Zyxin is a focal adhesion protein that has been implicated in the modulation of cell adhesion and motility, and is hypothesized to be a mechano-sensor in integrin-mediated responses to mechanical force. To test the functional role of zyxin in the mechanotransduction of microvascular smooth muscle cells (VSMC, we utilized atomic force microscopy (AFM to apply localized pulling forces to VSMC through a fibronectin (FN focal adhesion induced by a FN-coated bead on cell surface. Application of force with the AFM induced an increase of zyxin accumulation at the site of the FN-bead focal adhesion that accompanied the VSMC contractile response. Whereas, reduction of zyxin expression by using a zyxin-shRNA construct abolished the VSMC contractile response to AFM pulling forces, even though the zyxin-silenced VSMCs displayed increased adhesion to FN in both AFM adhesion assays and cell adhesion assays. The reduced zyxin expression significantly impaired cell spreading and reorganization of the actin cytoskeleton that could indicate a possible underlying reason for the loss of a contractile response to mechanical force. Consistent with these observations, zyxin silencing also resulted in reduced expression of Rac1, which plays an important role in the actin reorganization in VSMC, but increased TRIP6 and FAK expression, the latter being a major protein that promote cell adhesion. In conclusion, these data support an important enabling role for zyxin in VSMCs ability to mechanically respond to applied force.

  6. Functional Assay of Cancer Cell Invasion Potential Based on Mechanotransduction of Focused Ultrasound

    Directory of Open Access Journals (Sweden)

    Andrew C. Weitz

    2017-08-01

    Full Text Available Cancer cells undergo a number of biophysical changes as they transform from an indolent to an aggressive state. These changes, which include altered mechanical and electrical properties, can reveal important diagnostic information about disease status. Here, we introduce a high-throughput, functional technique for assessing cancer cell invasion potential, which works by probing for the mechanically excitable phenotype exhibited by invasive cancer cells. Cells are labeled with fluorescent calcium dye and imaged during stimulation with low-intensity focused ultrasound, a non-contact mechanical stimulus. We show that cells located at the focus of the stimulus exhibit calcium elevation for invasive prostate (PC-3 and DU-145 and bladder (T24/83 cancer cell lines, but not for non-invasive cell lines (BPH-1, PNT1A, and RT112/84. In invasive cells, ultrasound stimulation initiates a calcium wave that propagates from the cells at the transducer focus to other cells, over distances greater than 1 mm. We demonstrate that this wave is mediated by extracellular signaling molecules and can be abolished through inhibition of transient receptor potential channels and inositol trisphosphate receptors, implicating these proteins in the mechanotransduction process. If validated clinically, our technology could provide a means to assess tumor invasion potential in cytology specimens, which is not currently possible. It may therefore have applications in diseases such as bladder cancer, where cytologic diagnosis of tumor invasion could improve clinical decision-making.

  7. Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis

    Science.gov (United States)

    Liu, Longwei; You, Zhifeng; Yu, Hongsheng; Zhou, Lyu; Zhao, Hui; Yan, Xiaojun; Li, Dulei; Wang, Bingjie; Zhu, Lu; Xu, Yuzhou; Xia, Tie; Shi, Yan; Huang, Chenyu; Hou, Wei; Du, Yanan

    2017-12-01

    The role of pathological angiogenesis on liver fibrogenesis is still unknown. Here, we developed fibrotic microniches (FμNs) that recapitulate the interaction of liver sinusoid endothelial cells (LSECs) and hepatic stellate cells (HSCs). We investigated how the mechanical properties of their substrates affect the formation of capillary-like structures and how they relate to the progression of angiogenesis during liver fibrosis. Differences in cell response in the FμNs were synonymous of the early and late stages of liver fibrosis. The stiffness of the early-stage FμNs was significantly elevated due to condensation of collagen fibrils induced by angiogenesis, and led to activation of HSCs by LSECs. We utilized these FμNs to understand the response to anti-angiogenic drugs, and it was evident that these drugs were effective only for early-stage liver fibrosis in vitro and in an in vivo mouse model of liver fibrosis. Late-stage liver fibrosis was not reversed following treatment with anti-angiogenic drugs but rather with inhibitors of collagen condensation. Our work reveals stage-specific angiogenesis-induced liver fibrogenesis via a previously unrevealed mechanotransduction mechanism which may offer precise intervention strategies targeting stage-specific disease progression.

  8. Resolution of holograms produced by the fluid experiment system and the holography ground system

    Science.gov (United States)

    Brooks, Howard L.

    1987-01-01

    The Fluid Experiment System (FES) was developed to study low temperature crystal growth of triglycine sulfate from solution in a low gravity environment onboard Spacelab. The first flight of FES was in 1985. FES uses an optical system to take holograms of the growing crystal to be analyzed after the mission in the Holography Ground System (HGS) located in the Test Laboratory at Marshall Space Flight Center. Microscopic observation of the images formed by the reconstructed holograms is critical to determining crystal growth rate and particle velocity. FES and HGS were designed for a resolution of better than 20 micrometers, but initial observation of the flight holograms show a limit of 80 micrometers. The resolution of the FES holograms is investigated, as well as the role of beam intensity ratio and exposure time on the resolution of HGS produced holograms.

  9. Polydispersity effect on solid-fluid transition in hard sphere systems

    KAUST Repository

    Nogawa, T.

    2010-02-01

    The solid-fluid transition of the hard elastic particle system with size polydispersity is studied by molecular dynamics simulations. Using nonequilibrium relaxation from the mixed initial condition we determines the melting point where the first order transition between the solid, fcc crystal, and fluid states occurs. It is found that the density gap between the bistable states decreases with increasing the strength of the polydispersity and continuously approaches to zero at the critical point. © 2010.

  10. Development of new heat transfer media for improving efficiency in energy systems : conventional fluids and nanofluids

    OpenAIRE

    Cabaleiro Alvarez, David

    2016-01-01

    This PhD Thesis aims to characterize different conventional thermal fluids and propose new nanofluids based on their thermophysical, rheological, (solid-liquid) phase equilibria and their capability to heat transfer or heat storage. The selected conventional fluids are commonly used in the majority of heat transfer systems such as ethylene glycol (EG), propylene glycol (PG), a (ethylene glycol + water) mixture at 50 vol.% (EG+W), or the (diphenyl ether + biphenyl) mixtures. The nanofluids wer...

  11. Modeling Two-Phase Flow and Vapor Cycles Using the Generalized Fluid System Simulation Program

    Science.gov (United States)

    Smith, Amanda D.; Majumdar, Alok K.

    2017-01-01

    This work presents three new applications for the general purpose fluid network solver code GFSSP developed at NASA's Marshall Space Flight Center: (1) cooling tower, (2) vapor-compression refrigeration system, and (3) vapor-expansion power generation system. These systems are widely used across engineering disciplines in a variety of energy systems, and these models expand the capabilities and the use of GFSSP to include fluids and features that are not part of its present set of provided examples. GFSSP provides pressure, temperature, and species concentrations at designated locations, or nodes, within a fluid network based on a finite volume formulation of thermodynamics and conservation laws. This paper describes the theoretical basis for the construction of the models, their implementation in the current GFSSP modeling system, and a brief evaluation of the usefulness of the model results, as well as their applicability toward a broader spectrum of analytical problems in both university teaching and engineering research.

  12. Fluid-structure interaction in BWR suppression pool systems. Final report

    International Nuclear Information System (INIS)

    Nickell, R.E.

    1979-09-01

    The discharge of safety relief valves or a severe loss-of-coolant event in a boiling-water-cooled reactor steam supply system triggers a complex pressure suppression system that is based upon sub-surface steam condensation in large pools of water. The physical problems fall into two categories. The first is referred to as vent clearing and describes the process of expelling non-condensables from the system prior to steam flow. The second category covers a variety of phenomena related to the transient overexpansion of a condensable volume and the subsequent inertially-driven volume decrease. The dynamic loading of either event, depending upon fluid-structural design parameters, can be of concern in safety analysis. This report describes the development of a method for calculating the loads and the structural response for both types of problems. The method is embedded in a computer code, called PELE-IC, that couples a two-dimensional, incompressible eulerian fluid algorithm to a finite element shell algorithm. The fluid physics is based upon the SOLA algorithm, which provideds a trial velocity field using the Navier-Stokes equations that is subsequently corrected iteratively so that incompressibility, fluid-structure interface compatibility, and boundary conditions are satisfied. These fluid and fluid-structure algorithms have been extensively verified through calculations of known solutions from the classical literature, and by comparison to air and steam blowdown experiments

  13. Comments on Frequency Swept Rotating Input Perturbation Techniques and Identification of the Fluid Force Models in Rotor/bearing/seal Systems and Fluid Handling Machines

    Science.gov (United States)

    Muszynska, Agnes; Bently, Donald E.

    1991-01-01

    Perturbation techniques used for identification of rotating system dynamic characteristics are described. A comparison between two periodic frequency-swept perturbation methods applied in identification of fluid forces of rotating machines is presented. The description of the fluid force model identified by inputting circular periodic frequency-swept force is given. This model is based on the existence and strength of the circumferential flow, most often generated by the shaft rotation. The application of the fluid force model in rotor dynamic analysis is presented. It is shown that the rotor stability is an entire rotating system property. Some areas for further research are discussed.

  14. Development of fluid system design technology for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, D. J.; Chang, M. H.; Kang, D. J. and others

    1999-03-01

    This study presents the technology development of the system design concepts of SMART, a multi-purposed integral reactor with enhanced safety and operability, for use in diverse usages and applications of the nuclear energy. This report contains the following; - Design characteristics - Performance and safety related design criteria - System description: Primary system, Secondary system, Residual heat removal system, Make-up system, Component cooling system, Safety system - Development of design computer code: Steam generator performance(ONCESG), Pressurizer performance(COLDPZR), Steam generator flow instability(SGINS) - Development of component module and modeling using MMS computer code - Design calculation: Steam generator thermal sizing, Analysis of feed-water temperature increase at a low flow rate, Evaluation of thermal efficiency in the secondary system, Inlet orifice throttling coefficient for the prevention of steam generator flow instability, Analysis of Nitrogen gas temperature in the pressurizer during heat-up process, evaluation of water chemistry and erosion etc. The results of this study can be utilized not only for the foundation technology of the next phase basic system design of the SMART but also for the basic model in optimizing the system concepts for future advanced reactors. (author)

  15. Dissertation Defense Computational Fluid Dynamics Uncertainty Analysis for Payload Fairing Spacecraft Environmental Control Systems

    Science.gov (United States)

    Groves, Curtis Edward

    2014-01-01

    Spacecraft thermal protection systems are at risk of being damaged due to airflow produced from Environmental Control Systems. There are inherent uncertainties and errors associated with using Computational Fluid Dynamics to predict the airflow field around a spacecraft from the Environmental Control System. This paper describes an approach to quantify the uncertainty in using Computational Fluid Dynamics to predict airflow speeds around an encapsulated spacecraft without the use of test data. Quantifying the uncertainty in analytical predictions is imperative to the success of any simulation-based product. The method could provide an alternative to traditional "validation by test only" mentality. This method could be extended to other disciplines and has potential to provide uncertainty for any numerical simulation, thus lowering the cost of performing these verifications while increasing the confidence in those predictions. Spacecraft requirements can include a maximum airflow speed to protect delicate instruments during ground processing. Computational Fluid Dynamics can be used to verify these requirements; however, the model must be validated by test data. This research includes the following three objectives and methods. Objective one is develop, model, and perform a Computational Fluid Dynamics analysis of three (3) generic, non-proprietary, environmental control systems and spacecraft configurations. Several commercially available and open source solvers have the capability to model the turbulent, highly three-dimensional, incompressible flow regime. The proposed method uses FLUENT, STARCCM+, and OPENFOAM. Objective two is to perform an uncertainty analysis of the Computational Fluid Dynamics model using the methodology found in "Comprehensive Approach to Verification and Validation of Computational Fluid Dynamics Simulations". This method requires three separate grids and solutions, which quantify the error bars around Computational Fluid Dynamics

  16. Dissertation Defense: Computational Fluid Dynamics Uncertainty Analysis for Payload Fairing Spacecraft Environmental Control Systems

    Science.gov (United States)

    Groves, Curtis Edward

    2014-01-01

    Spacecraft thermal protection systems are at risk of being damaged due to airflow produced from Environmental Control Systems. There are inherent uncertainties and errors associated with using Computational Fluid Dynamics to predict the airflow field around a spacecraft from the Environmental Control System. This paper describes an approach to quantify the uncertainty in using Computational Fluid Dynamics to predict airflow speeds around an encapsulated spacecraft without the use of test data. Quantifying the uncertainty in analytical predictions is imperative to the success of any simulation-based product. The method could provide an alternative to traditional validation by test only mentality. This method could be extended to other disciplines and has potential to provide uncertainty for any numerical simulation, thus lowering the cost of performing these verifications while increasing the confidence in those predictions.Spacecraft requirements can include a maximum airflow speed to protect delicate instruments during ground processing. Computational Fluid Dynamics can be used to verify these requirements; however, the model must be validated by test data. This research includes the following three objectives and methods. Objective one is develop, model, and perform a Computational Fluid Dynamics analysis of three (3) generic, non-proprietary, environmental control systems and spacecraft configurations. Several commercially available and open source solvers have the capability to model the turbulent, highly three-dimensional, incompressible flow regime. The proposed method uses FLUENT, STARCCM+, and OPENFOAM. Objective two is to perform an uncertainty analysis of the Computational Fluid Dynamics model using the methodology found in Comprehensive Approach to Verification and Validation of Computational Fluid Dynamics Simulations. This method requires three separate grids and solutions, which quantify the error bars around Computational Fluid Dynamics predictions

  17. Analysis of the susceptibility in a fluid system with Neumann – plus boundary conditions

    Directory of Open Access Journals (Sweden)

    Djondjorov Peter

    2018-01-01

    Full Text Available The behaviour of the local and total susceptibilities of a fluid system bounded by different surfaces is studied in the framework of the Ginsburg-Landau Ising type model. The case of a plain geometry, Neumann-infinity boundary conditions under variations of the temperature and an external ordering field is considered. Exact analytic expressions for the order parameter, local and total susceptibilities in such a system are presented. They are used to analyse the phase behaviour of fluids confined in regions close to the bulk critical point of the respective infinite system.

  18. AqSo_NaCl: Computer program to calculate p-T-V-x properties in the H2O-NaCl fluid system applied to fluid inclusion research and pore fluid calculation

    Science.gov (United States)

    Bakker, Ronald J.

    2018-06-01

    The program AqSo_NaCl has been developed to calculate pressure - molar volume - temperature - composition (p-V-T-x) properties, enthalpy, and heat capacity of the binary H2O-NaCl system. The algorithms are designed in BASIC within the Xojo programming environment, and can be operated as stand-alone project with Macintosh-, Windows-, and Unix-based operating systems. A series of ten self-instructive interfaces (modules) are developed to calculate fluid inclusion properties and pore fluid properties. The modules may be used to calculate properties of pure NaCl, the halite-liquidus, the halite-vapourus, dew-point and bubble-point curves (liquid-vapour), critical point, and SLV solid-liquid-vapour curves at temperatures above 0.1 °C (with halite) and below 0.1 °C (with ice or hydrohalite). Isochores of homogeneous fluids and unmixed fluids in a closed system can be calculated and exported to a.txt file. Isochores calculated for fluid inclusions can be corrected according to the volumetric properties of quartz. Microthermometric data, i.e. dissolution temperatures and homogenization temperatures, can be used to calculated bulk fluid properties of fluid inclusions. Alternatively, in the absence of total homogenization temperature the volume fraction of the liquid phase in fluid inclusions can be used to obtain bulk properties.

  19. Modelling of Mass Transfer Phenomena in Chemical and Biochemical Reactor Systems using Computational Fluid Dynamics

    DEFF Research Database (Denmark)

    Larsson, Hilde Kristina

    the velocity and pressure distributions in a fluid. CFD also enables the modelling of several fluids simultaneously, e.g. gas bubbles in a liquid, as well as the presence of turbulence and dissolved chemicals in a fluid, and many other phenomena. This makes CFD an appreciated tool for studying flow structures......, mixing, and other mass transfer phenomena in chemical and biochemical reactor systems. In this project, four selected case studies are investigated in order to explore the capabilities of CFD. The selected cases are a 1 ml stirred microbioreactor, an 8 ml magnetically stirred reactor, a Rushton impeller...... and an ion-exchange reaction are also modelled and compared to experimental data. The thesis includes a comprehensive overview of the fundamentals behind a CFD software, as well as a more detailed review of the fluid dynamic phenomena investigated in this project. The momentum and continuity equations...

  20. A high-force controllable MR fluid damper–liquid spring suspension system

    International Nuclear Information System (INIS)

    Raja, Pramod; Wang, Xiaojie; Gordaninejad, Faramarz

    2014-01-01

    The goal of the present research is to investigate the feasibility of incorporating a liquid spring in a semi-active suspension system for use in heavy off-road vehicles. A compact compressible magneto-rheological (MR) fluid damper–liquid spring (CMRFD–LS) with high spring rate is designed, developed and tested. Compressible MR fluids with liquid spring and variable damping characteristics are used. These fluids can offer unique functions in reducing the volume/weight of vehicle struts and improving vehicle dynamic stability and safety. The proposed device consists of a cylinder and piston–rod arrangement with an internal annular MR fluid valve. The internal pressures in the chambers on either side of the piston develop the spring force, while the pressure difference across the MR valve produces the damping force, when the fluid flows through the MR valve. Harmonic characterization of the CMRFD–LS is performed and the force–displacement results are presented. A fluid-mechanics based model is also developed to predict the performance of the system at different operating conditions and compared to the experimental results. Good agreement between the experimental results and theoretical predictions has been achieved. (paper)

  1. Electrohydrodynamic aspects of two-fluid microfluidic systems

    DEFF Research Database (Denmark)

    Goranovic, Goran

    The goal of this thesis has been to explore fundamental theoretical principles behind micro Total Analysis Systems (µTAS), also known as lab-on-chip systems, as well as to make use of computer simulations as an evaluation technique in the process of developing and optimizing µTAS devises. This in...

  2. An Innovative Improvement of Engineering Learning System Using Computational Fluid Dynamics Concept

    Science.gov (United States)

    Hung, T. C.; Wang, S. K.; Tai, S. W.; Hung, C. T.

    2007-01-01

    An innovative concept of an electronic learning system has been established in an attempt to achieve a technology that provides engineering students with an instructive and affordable framework for learning engineering-related courses. This system utilizes an existing Computational Fluid Dynamics (CFD) package, Active Server Pages programming,…

  3. Microcontroller-driven fluid-injection system for atomic force microscopy.

    Science.gov (United States)

    Kasas, S; Alonso, L; Jacquet, P; Adamcik, J; Haeberli, C; Dietler, G

    2010-01-01

    We present a programmable microcontroller-driven injection system for the exchange of imaging medium during atomic force microscopy. Using this low-noise system, high-resolution imaging can be performed during this process of injection without disturbance. This latter circumstance was exemplified by the online imaging of conformational changes in DNA molecules during the injection of anticancer drug into the fluid chamber.

  4. Systems and Methods for Determining Water-Cut of a Fluid Mixture

    KAUST Repository

    Karimi, Muhammad Akram; Shamim, Atif; Arsalan, Muhammad

    2017-01-01

    Provided in some embodiments are systems and methods for measuring the water content (or water-cut) of a fluid mixture. Provided in some embodiments is a water-cut sensor system that includes a helical T-resonator, a helical ground conductor, and a

  5. Systems and Methods for Determining Water-Cut of a Fluid Mixture

    KAUST Repository

    Karimi, Muhammad Akram; Shamim, Atif; Arsalan, Muhammad

    2017-01-01

    Provided in some embodiments are systems and methods for measuring the water content (or water-cut) of a fluid mixture. Provided in some embodiments is a water-cut sensor system that includes a T-resonator, a ground conductor, and a separator. The T

  6. The Cocos Ridge hydrothermal system revealed by microthermometry of fluid and melt inclusions

    Science.gov (United States)

    Brandstätter, J.; Kurz, W.; Krenn, K.

    2017-12-01

    Microthermometric analyses of fluid and melt inclusions in hydrothermal veins and in the Cocos Ridge (CCR) basalt were used to reveal the CCR thermal history at IODP Site 344-U1414 and to constrain fluid source and flow. Hydrothermal veins are hosted by lithified sediments and CCR basalt . Site 344-U1414, located 1 km seaward of the Middle American Trench offshore Costa Rica, serves to evaluate fluid/rock interaction, the hydrologic system and geochemical processes linked with the tectonic evolution of the incoming Cocos Plate from the Early Miocene up to recent times. The veins in the sedimentary rocks are mainly filled by blocky calcite, containing numerous fluid inclusions, and sometimes crosscut fibrous quartz/chalcedony veins. The veins in the basalt can be differentiated into three types: antitaxial fibrous calcite veins, composite veins with fibrous calcite and clay minerals at the vein margins and spherulitic quartz in the center, and syntaxial blocky aragonite veins surrounded by a clay selvage in the uppermost CCR basalt sections. Secondary minerals, clay minerals, fibrous calcite, quartz/chalcedony and pyrite also filled vesicles in the basalt. Fluid inclusions were mainly found in the aragonite veins and rarely in quartz in the composite veins and vesicles. Blocky veins with embedded wall rock fragments appear in the sediments and in the basalt indicate hydraulic fracturing. The occurrence of decrepitated fluid inclusions show high homogenization temperatures up to 400 °C. Decrepitated fluid inclusions are formed by increased internal overpressure, related to isobaric heating. Elongated fluid inclusion planes, arc-like fluid inclusions and low homogenization temperatures indicate subsequent isobaric cooling. The results obtained so far from Raman spectroscopy and microthermometry indicate CO2 inclusions and petrographic observations suggest the presence of silicate melt inclusions in phenocrysts in the basalt (mainly in clinopyroxene and plagioclase

  7. Control of optical transport parameters of 'porous medium – supercritical fluid' systems

    Energy Technology Data Exchange (ETDEWEB)

    Zimnyakov, D A; Ushakova, O V; Yuvchenko, S A [Yuri Gagarin State Technical University of Saratov, Saratov (Russian Federation); Bagratashvili, V N [M. V. Lomonosov Moscow State University, Moscow (Russian Federation)

    2015-11-30

    The possibility of controlling optical transport parameters (in particular, transport scattering coefficient) of porous systems based on polymer fibres, saturated with carbon dioxide in different phase states (gaseous, liquid and supercritical) has been experimentally studied. An increase in the pressure of the saturating medium leads to a rise of its refractive index and, correspondingly, the diffuse-transmission coefficient of the system due to the decrease in the transport scattering coefficient. It is shown that, in the case of subcritical saturating carbon dioxide, the small-angle diffuse transmission of probed porous layers at pressures close to the saturated vapour pressure is determined by the effect of capillary condensation in pores. The immersion effect in 'porous medium – supercritical fluid' systems, where the fluid pressure is used as a control parameter, is considered. The results of reconstructing the values of transport scattering coefficient of probed layers for different refractive indices of a saturating fluid are presented. (radiation scattering)

  8. IGF-1 signaling mediated cell-specific skeletal mechano-transduction.

    Science.gov (United States)

    Tian, Faming; Wang, Yongmei; Bikle, Daniel D

    2018-02-01

    Mechanical loading preserves bone mass and stimulates bone formation, whereas skeletal unloading leads to bone loss. In addition to osteocytes, which are considered the primary sensor of mechanical load, osteoblasts, and bone specific mesenchymal stem cells also are involved. The skeletal response to mechanical signals is a complex process regulated by multiple signaling pathways including that of insulin-like growth factor-1 (IGF-1). Conditional osteocyte deletion of IGF-1 ablates the osteogenic response to mechanical loading. Similarly, osteocyte IGF-1 receptor (IGF-1R) expression is necessary for reloading-induced periosteal bone formation. Transgenic overexpression of IGF-1 in osteoblasts results in enhanced responsiveness to in vivo mechanical loading in mice, a response which is eliminated by osteoblastic conditional disruption of IGF-1 in vivo. Bone marrow derived stem cells (BMSC) from unloaded bone fail to respond to IGF-1 in vitro. IGF-1R is required for the transduction of a mechanical stimulus to downstream effectors, transduction which is lost when the IGF-1R is deleted. Although the molecular mechanisms are not yet fully elucidated, the IGF signaling pathway and its interactions with potentially interlinked signaling cascades involving integrins, the estrogen receptor, and wnt/β-catenin play an important role in regulating adaptive response of cancer bone cells to mechanical stimuli. In this review, we discuss recent advances investigating how IGF-1 and other interlinked molecules and signaling pathways regulate skeletal mechano-transduction involving different bone cells, providing an overview of the IGF-1 signaling mediated cell-specific response to mechanical stimuli. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:576-583, 2018. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  9. Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling.

    Directory of Open Access Journals (Sweden)

    Hiromitsu Negoro

    Full Text Available Urothelial cells respond to bladder distension with ATP release, and ATP signaling within the bladder and from the bladder to the CNS is essential for proper bladder function. In other cell types, pannexin 1 (Panx1 channels provide a pathway for mechanically-induced ATP efflux and for ATP-induced ATP release through interaction with P2X7 receptors (P2X7Rs. We report that Panx1 and P2X7R are functionally expressed in the bladder mucosa and in immortalized human urothelial cells (TRT-HU1, and participate in urothelial ATP release and signaling. ATP release from isolated rat bladders induced by distention was reduced by the Panx1 channel blocker mefloquine (MFQ and was blunted in mice lacking Panx1 or P2X7R expression. Hypoosmotic shock induced YoPro dye uptake was inhibited by MFQ and the P2X7R blocker A438079 in TRT-HU1 cells, and was also blunted in primary urothelial cells derived from mice lacking Panx1 or P2X7R expression. Rinsing-induced mechanical stimulation of TRT-HU1 cells triggered ATP release, which was reduced by MFQ and potentiated in low divalent cation solution (LDPBS, a condition known to enhance P2X7R activation. ATP signaling evaluated as intercellular Ca2+ wave radius was significantly larger in LDPBS, reduced by MFQ and by apyrase (ATP scavenger. These findings indicate that Panx1 participates in urothelial mechanotransduction and signaling by providing a direct pathway for mechanically-induced ATP release and by functionally interacting with P2X7Rs.

  10. The fluid-filling system for the Borexino solar neutrino detector

    Science.gov (United States)

    Benziger, J.; Cadonati, L.; Calaprice, F.; Chen, M.; Corsi, A.; Dalnoki-Veress, F.; Fernholz, R.; Ford, R.; Galbiati, C.; Goretti, A.; Harding, E.; Ianni, Aldo; Ianni, Andrea; Kidner, S.; Leung, M.; Loeser, F.; McCarty, K.; McKinsey, D.; Nelson, A.; Pocar, A.; Salvo, C.; Schimizzi, D.; Shutt, T.; Sonnenschein, A.

    2009-09-01

    The system for controlled filling of the nested flexible scintillator containment vessels in the Borexino solar neutrino detector is described. The design and operation principles of pressure and shape monitoring systems are presented for gas filling, gas displacement by water, and water displacement by scintillator. System specifications for safety against overstressing the flexible nylon vessels are defined as well as leak-tightness and cleanliness requirements. The fluid-filling system was a major engineering challenge for the Borexino detector.

  11. The Interplay Between Saline Fluid Flow and Dynamic Permeability in Magmatic-Hydrothermal Systems

    Science.gov (United States)

    Weis, P.

    2014-12-01

    Magmatic-hydrothermal ore deposits document the interplay between saline fluid flow and rock permeability. Numerical simulations of multi-phase flow of variably miscible, compressible H20-NaCl fluids in concert with a dynamic permeability model can reproduce characteristics of porphyry copper and epithermal gold systems. This dynamic permeability model incorporates depth-dependent permeability profiles characteristic for tectonically active crust as well as pressure- and temperature-dependent relationships describing hydraulic fracturing and the transition from brittle to ductile rock behavior. In response to focused expulsion of magmatic fluids from a crystallizing upper crustal magma chamber, the hydrothermal system self-organizes into a hydrological divide, separating an inner part dominated by ascending magmatic fluids under near-lithostatic pressures from a surrounding outer part dominated by convection of colder meteoric fluids under near-hydrostatic pressures. This hydrological divide also provides a mechanism to transport magmatic salt through the crust, and prevents the hydrothermal system to become "clogged" by precipitation of solid halite due to depressurization of saline, high-temperature magmatic fluids. The same physical processes at similar permeability ranges, crustal depths and flow rates are relevant for a number of active systems, including geothermal resources and excess degassing at volcanos. The simulations further suggest that the described mechanism can separate the base of free convection in high-enthalpy geothermal systems from the magma chamber as a driving heat source by several kilometers in the vertical direction in tectonic settings with hydrous magmatism. This hydrology would be in contrast to settings with anhydrous magmatism, where the base of the geothermal systems may be closer to the magma chamber.

  12. DYNAPO 4 - a fluid system and frames analysis computer program

    International Nuclear Information System (INIS)

    Lefter, J.D.; Ahdout, H.

    1982-01-01

    DYNAPO 4 is a user oriented specialized computer program, capable of analyzing three-dimensional linear elastic piping systems or frames for static loads, dynamic loads represented by acceleration response spectra, transient dynamic loads represented by harmonic, polynomial of second order, and time history forcing functions. DYNAPO 4 has plotting capability, which plots the input configuration of the piping system or of the structure and also plots its deformed shape after the load is applied. DYNAPO 4 performs the analysis for ASME Section III Class 1, Class 2, and 3, piping, and provides the user with stress reports as per ASME and ANSI Code requirements. 3 refs

  13. Simulating coupled dynamics of a rigid-flexible multibody system and compressible fluid

    Science.gov (United States)

    Hu, Wei; Tian, Qiang; Hu, HaiYan

    2018-04-01

    As a subsequent work of previous studies of authors, a new parallel computation approach is proposed to simulate the coupled dynamics of a rigid-flexible multibody system and compressible fluid. In this approach, the smoothed particle hydrodynamics (SPH) method is used to model the compressible fluid, the natural coordinate formulation (NCF) and absolute nodal coordinate formulation (ANCF) are used to model the rigid and flexible bodies, respectively. In order to model the compressible fluid properly and efficiently via SPH method, three measures are taken as follows. The first is to use the Riemann solver to cope with the fluid compressibility, the second is to define virtual particles of SPH to model the dynamic interaction between the fluid and the multibody system, and the third is to impose the boundary conditions of periodical inflow and outflow to reduce the number of SPH particles involved in the computation process. Afterwards, a parallel computation strategy is proposed based on the graphics processing unit (GPU) to detect the neighboring SPH particles and to solve the dynamic equations of SPH particles in order to improve the computation efficiency. Meanwhile, the generalized-alpha algorithm is used to solve the dynamic equations of the multibody system. Finally, four case studies are given to validate the proposed parallel computation approach.

  14. Role of the Enteric Nervous System in the Fluid and Electrolyte Secretion of Rotavirus Diarrhea

    Science.gov (United States)

    Lundgren, Ove; Peregrin, Attila Timar; Persson, Kjell; Kordasti, Shirin; Uhnoo, Ingrid; Svensson, Lennart

    2000-01-01

    The mechanism underlying the intestinal fluid loss in rotavirus diarrhea, which often afflicts children in developing countries, is not known. One hypothesis is that the rotavirus evokes intestinal fluid and electrolyte secretion by activation of the nervous system in the intestinal wall, the enteric nervous system (ENS). Four different drugs that inhibit ENS functions were used to obtain experimental evidence for this hypothesis in mice in vitro and in vivo. The involvement of the ENS in rotavirus diarrhea indicates potential sites of action for drugs in the treatment of the disease.

  15. Considerations of a nonhomogeneous fluid in the deep groundwater flow system at Hanford

    International Nuclear Information System (INIS)

    Nelson, R.W.

    1988-11-01

    This report presents such a general theory capable of describing the flow on nonhomogeneous fluids in porous media, theory that is a composite from several disciplines including groundwater hydrology, soil physics, civil engineering, petroleum reservoir engineering, mechanics, and mathematical physics. The report discussed the conceptual basis for considering the flow of nonhomogeneous fluids. From this conceptual basis emphasis shifts to providing complete definitions and then appropriately describing those definitions in mathematical terms. Throughout the report, the necessary assumptions are stated in detail because the limitations of any theory are best assessed through careful scrutiny of the assumptions. From the mathematical definitions with appropriate functional dependence the results and constraints needed are derived to provide the general theory necessary to describe the flow of nonhomogeneous fluids in porous media. Particular attention is given to comparing the general theory with the classical theory of flow for a homogeneous fluid. Such comparison provides significant insight to the effects of variable fluid properties on subsurface flow systems. The comparisons also indicate the importance of carefully formulating subsurface flow models within the more general theoretical framework describing the flow of nonhomogeneous fluids in porous media. 29 refs.; 6 figs.; 1 tab

  16. Numerical Modeling of Pressurization of Cryogenic Propellant Tank for Integrated Vehicle Fluid System

    Science.gov (United States)

    Majumdar, Alok K.; LeClair, Andre C.; Hedayat, Ali

    2016-01-01

    This paper presents a numerical model of pressurization of a cryogenic propellant tank for the Integrated Vehicle Fluid (IVF) system using the Generalized Fluid System Simulation Program (GFSSP). The IVF propulsion system, being developed by United Launch Alliance, uses boiloff propellants to drive thrusters for the reaction control system as well as to run internal combustion engines to develop power and drive compressors to pressurize propellant tanks. NASA Marshall Space Flight Center (MSFC) has been running tests to verify the functioning of the IVF system using a flight tank. GFSSP, a finite volume based flow network analysis software developed at MSFC, has been used to develop an integrated model of the tank and the pressurization system. This paper presents an iterative algorithm for converging the interface boundary conditions between different component models of a large system model. The model results have been compared with test data.

  17. Numerical Modeling of an Integrated Vehicle Fluids System Loop for Pressurizing a Cryogenic Tank

    Science.gov (United States)

    LeClair, A. C.; Hedayat, A.; Majumdar, A. K.

    2017-01-01

    This paper presents a numerical model of the pressurization loop of the Integrated Vehicle Fluids (IVF) system using the Generalized Fluid System Simulation Program (GFSSP). The IVF propulsion system, being developed by United Launch Alliance to reduce system weight and enhance reliability, uses boiloff propellants to drive thrusters for the reaction control system as well as to run internal combustion engines to develop power and drive compressors to pressurize propellant tanks. NASA Marshall Space Flight Center (MSFC) conducted tests to verify the functioning of the IVF system using a flight-like tank. GFSSP, a finite volume based flow network analysis software developed at MSFC, has been used to support the test program. This paper presents the simulation of three different test series, comparison of numerical prediction and test data and a novel method of presenting data in a dimensionless form. The paper also presents a methodology of implementing a compressor map in a system level code.

  18. Leak detection system for a high temperature fluid pipe

    International Nuclear Information System (INIS)

    Puyal, C.; Meuwisse, C.

    1989-01-01

    The leak detection system is made by a cable with at least two isolated electrical conductors, close to the wall of the pipe. The material of the cable is chosen so as to change its electrical characteristics if a leak causes heating of the cable. A detector at one end of the cable can measure the modifications of the electrical characteristics [fr

  19. Refining the Subseafloor Circulation Model of the Middle Valley Hydrothermal System Using Fluid Geochemistry

    Science.gov (United States)

    Inderbitzen, K. E.; Wheat, C. G.; Baker, P. A.; Fisher, A. T.

    2014-12-01

    Currently, fluid circulation patterns and the evolution of rock/fluid compositions as circulation occurs in subseafloor hydrothermal systems are poorly constrained. Sedimented spreading centers provide a unique opportunity to study subsurface flow because sediment acts as an insulating blanket that traps heat from the cooling magma body and limits: (a) potential flow paths for seawater to recharge the aquifer in permeable upper basaltic basement and (b) points of altered fluid egress. This also allows for a range of thermal and geochemical gradients to exist near the sediment-water interface. Models of fluid circulation patterns in this type of hydrologic setting have been generated (eg. Stein and Fisher, 2001); however fluid chemistry datasets have not previously been used to test the model's viability. We address this issue by integrating the existing circulation model with fluid compositional data collected from sediment pore waters and high temperature hydrothermal vents located in Middle Valley on the Juan de Fuca Ridge. Middle Valley hosts a variety of hydrologic regimes: including areas of fluid recharge (Site 855), active venting (Site 858/1036; Dead Dog vent field), recent venting (Site 856/1035; Bent Hill Massive Sulfide deposit) and a section of heavily sedimented basement located between recharge and discharge sites (Site 857). We will present new results based on thermal and geochemical data from the area of active venting (Sites 858 and 1036), that was collected during Ocean Drilling Program Legs 139 and 169 and a subsequent heat flow/gravity coring effort. These results illuminate fine scale controls on secondary recharge and fluid flow within the sediment section at Site 858/1036. The current status of high temperature vents in this area (based on observations made in July, 2014) will also be outlined.

  20. Proteomic Dissection of Nanotopography-Sensitive Mechanotransductive Signaling Hubs that Foster Neuronal Differentiation in PC12 Cells

    Directory of Open Access Journals (Sweden)

    Elisa Maffioli

    2018-01-01

    Full Text Available Neuronal cells are competent in precisely sensing nanotopographical features of their microenvironment. The perceived microenvironmental information will be “interpreted” by mechanotransductive processes and impacts on neuronal functioning and differentiation. Attempts to influence neuronal differentiation by engineering substrates that mimic appropriate extracellular matrix (ECM topographies are hampered by the fact that profound details of mechanosensing/-transduction complexity remain elusive. Introducing omics methods into these biomaterial approaches has the potential to provide a deeper insight into the molecular processes and signaling cascades underlying mechanosensing/-transduction but their exigence in cellular material is often opposed by technical limitations of major substrate top-down fabrication methods. Supersonic cluster beam deposition (SCBD allows instead the bottom-up fabrication of nanostructured substrates over large areas characterized by a quantitatively controllable ECM-like nanoroughness that has been recently shown to foster neuron differentiation and maturation. Exploiting this capacity of SCBD, we challenged mechanosensing/-transduction and differentiative behavior of neuron-like PC12 cells with diverse nanotopographies and/or changes of their biomechanical status, and analyzed their phosphoproteomic profiles in these settings. Versatile proteins that can be associated to significant processes along the mechanotransductive signal sequence, i.e., cell/cell interaction, glycocalyx and ECM, membrane/f-actin linkage and integrin activation, cell/substrate interaction, integrin adhesion complex, actomyosin organization/cellular mechanics, nuclear organization, and transcriptional regulation, were affected. The phosphoproteomic data suggested furthermore an involvement of ILK, mTOR, Wnt, and calcium signaling in these nanotopography- and/or cell mechanics-related processes. Altogether, potential nanotopography

  1. Relative entropies in thermodynamics of complete fluid systems

    Czech Academy of Sciences Publication Activity Database

    Feireisl, Eduard

    2012-01-01

    Roč. 32, č. 9 (2012), s. 3059-3080 ISSN 1078-0947 R&D Projects: GA ČR GA201/09/0917 Institutional research plan: CEZ:AV0Z10190503 Keywords : relative entropy * Navier-Stokes-Fourier system * weak-strong uniqueness Subject RIV: BA - General Mathematics Impact factor: 1.005, year: 2012 http://www.aimsciences.org/journals/displayArticlesnew.jsp?paperID=7281

  2. Long time behavior and attractors for energetically insulated fluid systems

    Czech Academy of Sciences Publication Activity Database

    Feireisl, Eduard

    2010-01-01

    Roč. 27, č. 4 (2010), s. 1587-1609 ISSN 1078-0947 R&D Projects: GA ČR GA201/09/0917 Institutional research plan: CEZ:AV0Z10190503 Keywords : Navier-Stokes-Fourier system * attractor * long time behavior Subject RIV: BA - General Mathematics Impact factor: 0.986, year: 2010 http://www.aimsciences.org/journals/displayArticles.jsp?paperID=5040

  3. Experimental system model of a primary active fluid

    International Nuclear Information System (INIS)

    Deseigne, Julien

    2010-01-01

    Collective motion, such as flocks of birds or shoals of fish, is ubiquitous in nature. Such fundamentally out-of-equilibrium phenomena may be described with the new conceptual background of polar active matter, a system of polar particles which enables to use provided energy in order to move in their own directions. A 2D experimental system of vibrated polar disks that interact only by contact has been set up. These disks behave as random walkers, whose trajectories are characterized by a persistence length greater than their size and controlled by the angular fluctuations of their polarity. The interplay between the hard-core repulsion and the persistence of the motion leads to complex alignment modes. For instance, only 10 pc of the binary collisions correspond to an effective ferromagnetic alignment. Yet, spontaneous collective motion inside the system characterized by giant fluctuations of density have been observed. These results reveal the robustness of the polar order observed in theoretical and numerical models of 2D polar active matter on substrate

  4. The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic' system?

    Science.gov (United States)

    Abbott, N Joan; Pizzo, Michelle E; Preston, Jane E; Janigro, Damir; Thorne, Robert G

    2018-03-01

    Brain fluids are rigidly regulated to provide stable environments for neuronal function, e.g., low K + , Ca 2+ , and protein to optimise signalling and minimise neurotoxicity. At the same time, neuronal and astroglial waste must be promptly removed. The interstitial fluid (ISF) of the brain tissue and the cerebrospinal fluid (CSF) bathing the CNS are integral to this homeostasis and the idea of a glia-lymph or 'glymphatic' system for waste clearance from brain has developed over the last 5 years. This links bulk (convective) flow of CSF into brain along the outside of penetrating arteries, glia-mediated convective transport of fluid and solutes through the brain extracellular space (ECS) involving the aquaporin-4 (AQP4) water channel, and finally delivery of fluid to venules for clearance along peri-venous spaces. However, recent evidence favours important amendments to the 'glymphatic' hypothesis, particularly concerning the role of glia and transfer of solutes within the ECS. This review discusses studies which question the role of AQP4 in ISF flow and the lack of evidence for its ability to transport solutes; summarizes attributes of brain ECS that strongly favour the diffusion of small and large molecules without ISF flow; discusses work on hydraulic conductivity and the nature of the extracellular matrix which may impede fluid movement; and reconsiders the roles of the perivascular space (PVS) in CSF-ISF exchange and drainage. We also consider the extent to which CSF-ISF exchange is possible and desirable, the impact of neuropathology on fluid drainage, and why using CSF as a proxy measure of brain components or drug delivery is problematic. We propose that new work and key historical studies both support the concept of a perivascular fluid system, whereby CSF enters the brain via PVS convective flow or dispersion along larger caliber arteries/arterioles, diffusion predominantly regulates CSF/ISF exchange at the level of the neurovascular unit associated with

  5. Calculation Sheet for the Basic Design of the ATLAS Fluid System

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hyun Sik; Moon, S. K.; Yun, B. J.; Kwon, T. S.; Choi, K. Y.; Cho, S.; Park, C. K.; Lee, S. J.; Kim, Y. S.; Song, C. H.; Baek, W. P.; Hong, S. D

    2007-03-15

    The basic design of an integral effect test loop for pressurized water reactors (PWRs), the ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation), has been carried out by Thermal-Hydraulics Safety Research Team in Korea Atomic Energy Research Institute (KAERI). The ATLAS facility has been designed to have the length scale of 1/2 and area scale of 1/144 compared with the reference plant, APR1400, and is scaled for full pressure and temperature conditions. This report includes calculation sheets for the basic design of ATLAS fluid systems, which are consisted of a reactor pressure vessel with core simulator, the primary loop piping, a pressurizer, reactor coolant pumps, steam generators, the secondary system, the safety system, the auxiliary system, and the heat loss compensation system. The present calculation sheets will be used to help understanding the basic design of the ATLAS fluid system and its based scaling methodology.

  6. Modeling and Control of Magnetic Fluid Deformable Mirrors for Adaptive Optics Systems

    CERN Document Server

    Wu, Zhizheng; Ben Amara, Foued

    2013-01-01

    Modeling and Control of Magnetic Fluid Deformable Mirrors for Adaptive Optics Systems presents a novel design of wavefront correctors based on magnetic fluid deformable mirrors (MFDM) as well as corresponding control algorithms. The presented wavefront correctors are characterized by their linear, dynamic response. Various mirror surface shape control algorithms are presented along with experimental evaluations of the performance of the resulting adaptive optics systems. Adaptive optics (AO) systems are used in various fields of application to enhance the performance of optical systems, such as imaging, laser, free space optical communication systems, etc. This book is intended for undergraduate and graduate students, professors, engineers, scientists and researchers working on the design of adaptive optics systems and their various emerging fields of application. Zhizheng Wu is an associate professor at Shanghai University, China. Azhar Iqbal is a research associate at the University of Toronto, Canada. Foue...

  7. Calculation Sheet for the Basic Design of the ATLAS Fluid System

    International Nuclear Information System (INIS)

    Park, Hyun Sik; Moon, S. K.; Yun, B. J.; Kwon, T. S.; Choi, K. Y.; Cho, S.; Park, C. K.; Lee, S. J.; Kim, Y. S.; Song, C. H.; Baek, W. P.; Hong, S. D.

    2007-03-01

    The basic design of an integral effect test loop for pressurized water reactors (PWRs), the ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation), has been carried out by Thermal-Hydraulics Safety Research Team in Korea Atomic Energy Research Institute (KAERI). The ATLAS facility has been designed to have the length scale of 1/2 and area scale of 1/144 compared with the reference plant, APR1400, and is scaled for full pressure and temperature conditions. This report includes calculation sheets for the basic design of ATLAS fluid systems, which are consisted of a reactor pressure vessel with core simulator, the primary loop piping, a pressurizer, reactor coolant pumps, steam generators, the secondary system, the safety system, the auxiliary system, and the heat loss compensation system. The present calculation sheets will be used to help understanding the basic design of the ATLAS fluid system and its based scaling methodology

  8. A graphical criterion for working fluid selection and thermodynamic system comparison in waste heat recovery

    International Nuclear Information System (INIS)

    Xi, Huan; Li, Ming-Jia; He, Ya-Ling; Tao, Wen-Quan

    2015-01-01

    In the present study, we proposed a graphical criterion called CE diagram by achieving the Pareto optimal solutions of the annual cash flow and exergy efficiency. This new graphical criterion enables both working fluid selection and thermodynamic system comparison for waste heat recovery. It's better than the existing criterion based on single objective optimization because it is graphical and intuitionistic in the form of diagram. The features of CE diagram were illustrated by studying 5 examples with different heat-source temperatures (ranging between 100 °C to 260 °C), 26 chlorine-free working fluids and two typical ORC systems including basic organic Rankine cycle(BORC) and recuperative organic Rankine cycle (RORC). It is found that the proposed graphical criterion is feasible and can be applied to any closed loop waste heat recovery thermodynamic systems and working fluids. - Highlights: • A graphical method for ORC system comparison/working fluid selection was proposed. • Multi-objectives genetic algorithm (MOGA) was applied for optimizing ORC systems. • Application cases were performed to demonstrate the usage of the proposed method.

  9. Study of the hard-disk system at high densities: the fluid-hexatic phase transition.

    Science.gov (United States)

    Mier-Y-Terán, Luis; Machorro-Martínez, Brian Ignacio; Chapela, Gustavo A; Del Río, Fernando

    2018-06-21

    Integral equations of uniform fluids have been considered unable to predict any characteristic feature of the fluid-solid phase transition, including the shoulder that arises in the second peak of the fluid-phase radial distribution function, RDF, of hard-core systems obtained by computer simulations, at fluid densities very close to the structural two-step phase transition. This reasoning is based on the results of traditional integral approximations, like Percus-Yevick, PY, which does not show such a shoulder in hard-core systems, neither in two nor three dimensions. In this work, we present results of three Ansätze, based on the PY theory, that were proposed to remedy the lack of PY analytical solutions in two dimensions. This comparative study shows that one of those Ansätze does develop a shoulder in the second peak of the RDF at densities very close to the phase transition, qualitatively describing this feature. Since the shoulder grows into a peak at still higher densities, this integral equation approach predicts the appearance of an orientational order characteristic of the hexatic phase in a continuous fluid-hexatic phase transition.

  10. Weakly nonlinear dynamics in noncanonical Hamiltonian systems with applications to fluids and plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, P.J., E-mail: morrison@physics.utexas.edu [Department of Physics and Institute for Fusion Studies, University of Texas, Austin (United States); Vanneste, J. [School of Mathematics and Maxwell Institute for Mathematical Sciences, University of Edinburgh (United Kingdom)

    2016-05-15

    A method, called beatification, is presented for rapidly extracting weakly nonlinear Hamiltonian systems that describe the dynamics near equilibria of systems possessing Hamiltonian form in terms of noncanonical Poisson brackets. The procedure applies to systems like fluids and plasmas in terms of Eulerian variables that have such noncanonical Poisson brackets, i.e., brackets with nonstandard and possibly degenerate form. A collection of examples of both finite and infinite dimensions is presented.

  11. Fluid shut-down system for a nuclear reactor

    International Nuclear Information System (INIS)

    Barclay, F.W.; Frey, J.R.; Wilson, J.N.; Besant, R.W.

    1975-01-01

    A nuclear reactor shut-down system is described which comprises a fluidic vortex valve for releasably maintaining a liquid neutron poison outside of the reactor core, the poison being contained by a reservoir and biased by pressure for flow into poison tubes within the reactor. The upper ends of the poison tubes communicate with the supply port of the vortex valve. A continuous gas flow into the control port maintains normal controlled operation. Shut-down is effected by interruption of the control input. One embodiment comprises three groups of poison tubes and one vortex valve associated with each group wherein shut-down is effected by poison release in two out of the three groups. Preferably, each vortex valve comprises three control ports which operate on a ''voting'' or two-out-of-three basis. (Official Gazette)

  12. A deep crustal fluid channel into the San Andreas Fault system near Parkfield, California

    Science.gov (United States)

    Becken, M.; Ritter, O.; Park, S.K.; Bedrosian, P.A.; Weckmann, U.; Weber, M.

    2008-01-01

    Magnetotelluric (MT) data from 66 sites along a 45-km-long profile across the San Andreas Fault (SAF) were inverted to obtain the 2-D electrical resistivity structure of the crust near the San Andreas Fault Observatory at Depth (SAFOD). The most intriguing feature of the resistivity model is a steeply dipping upper crustal high-conductivity zone flanking the seismically defined SAF to the NE, that widens into the lower crust and appears to be connected to a broad conductivity anomaly in the upper mantle. Hypothesis tests of the inversion model suggest that upper and lower crustal and upper-mantle anomalies may be interconnected. We speculate that the high conductivities are caused by fluids and may represent a deep-rooted channel for crustal and/or mantle fluid ascent. Based on the chemical analysis of well waters, it was previously suggested that fluids can enter the brittle regime of the SAF system from the lower crust and mantle. At high pressures, these fluids can contribute to fault-weakening at seismogenic depths. These geochemical studies predicted the existence of a deep fluid source and a permeable pathway through the crust. Our resistivity model images a conductive pathway, which penetrates the entire crust, in agreement with the geochemical interpretation. However, the resistivity model also shows that the upper crustal branch of the high-conductivity zone is located NE of the seismically defined SAF, suggesting that the SAF does not itself act as a major fluid pathway. This interpretation is supported by both, the location of the upper crustal high-conductivity zone and recent studies within the SAFOD main hole, which indicate that pore pressures within the core of the SAF zone are not anomalously high, that mantle-derived fluids are minor constituents to the fault-zone fluid composition and that both the volume of mantle fluids and the fluid pressure increase to the NE of the SAF. We further infer from the MT model that the resistive Salinian block

  13. Subseafloor Microbial Life in Venting Fluids from the Mid Cayman Rise Hydrothermal System

    Science.gov (United States)

    Huber, J. A.; Reveillaud, J.; Reddington, E.; McDermott, J. M.; Sylva, S. P.; Breier, J. A.; German, C. R.; Seewald, J.

    2012-12-01

    in Piccard vent fluids, a basalt-hosted black smoker site located at ~4950 m with a maximum temperature of 403 °C. However, hyperthermophilic and thermophilic heterotrophs of the genus Thermococcus were isolated from Piccard vent fluids, but not Von Damm. These obligate anaerobes, growing optimally at 55-90 °C, are ubiquitous at hydrothermal systems and serve as a readily cultivable indicator organism of subseafloor populations. Finally, molecular analysis of vent fluids is on-going and will define the microbial population structure in this novel ecosystem and allow for direct comparisons with other deep-sea and subsurface habitats as part of our continuing efforts to explore the deep microbial biosphere on Earth.

  14. Dilational viscoelastic properties of fluid interfaces - III mixed surfactant systems

    Energy Technology Data Exchange (ETDEWEB)

    Djabbarah, N.F.; Wasan, D.T.

    1982-01-01

    The surface viscosity and elasticity of solutions of mixed surfactants were determined using the longitudinal wave technique combined with tracer particle measurements. The recent analysis of Maru et al., which was restricted to insoluble monolayers and to monolayers adsorbed from a single surfactant solution, has now been extended to multicomponent solutions. This analysis can be used not only to estimate the ''net'' viscoelastic properties at gas-liquid interfaces but also to estimate the composition as well as the intrinsic viscoelastic properties. Furthermore, when accompanied by separate measurements of shear viscoelastic properties, the above analysis can be used for the determination of dilational viscosity and elasticity. Surface viscoelasticity measurements were conducted on aqueous solutions of sodium lauryl sulfate and sodium lauryl sulfate-lauryl alcohol. Net surface viscosity and elasticity of sodium lauryl sulfate solutions increased with bulk concentration and reached a maximum at a concentration in the neighborhood of the critical micelle concentration. The presence of small amount of lauryl alcohol caused almost an order of magnitude increase in intrinsic surface viscosity and a similar increase in compositional surface elasticity. A comparison between the values of intrinsic surface viscosity and those of surface shear viscosity indicated that surface dilational viscosity exceeds surface shear viscosity by at least two orders of magnitude. These appear to be the first set of data presented hitherto for the surface dilational properties in addition to surface shear properties for the same mixed surfactant systems.

  15. Fluid transient analysis and design considerations in TVA PWR feedwater systems and steam generators

    International Nuclear Information System (INIS)

    Kelley, B.T.

    1979-01-01

    TVA has evaluated a number of fluid transients in an effort to discover areas of potential problems and to improve overall unit operation. The transients recently or currently being evaluated fall into four major areas - accident analyses, fast valving, heater drain systems, and steam generators. A discussion of each area follows

  16. Research Summary 3-D Computational Fluid Dynamics (CFD) Model Of The Human Respiratory System

    Science.gov (United States)

    The U.S. EPA’s Office of Research and Development (ORD) has developed a 3-D computational fluid dynamics (CFD) model of the human respiratory system that allows for the simulation of particulate based contaminant deposition and clearance, while being adaptable for age, ethnicity,...

  17. Modelling dynamic liquid-gas systems: Extensions to the volume-of-fluid solver

    CSIR Research Space (South Africa)

    Heyns, Johan A

    2013-06-01

    Full Text Available This study presents the extension of the volume-of-fluid solver, interFoam, for improved accuracy and efficiency when modelling dynamic liquid-gas systems. Examples of these include the transportation of liquids, such as in the case of fuel carried...

  18. Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease

    DEFF Research Database (Denmark)

    Baunbæk Egelund, Gertrud; Ertner, Gideon; Langholz Kristensen, Kristina

    2017-01-01

    Cerebrospinal fluid (CSF) analysis is the most important tool for assessing central nervous system (CNS) disease. An elevated CSF leukocyte count rarely provides the final diagnosis, but is almost always an indicator of inflammation within the CNS.The present study investigated the variety...

  19. RELAP5 two-phase fluid model and numerical scheme for economic LWR system simulation

    International Nuclear Information System (INIS)

    Ransom, V.H.; Wagner, R.J.; Trapp, J.A.

    1981-01-01

    The RELAP5 two-phase fluid model and the associated numerical scheme are summarized. The experience accrued in development of a fast running light water reactor system transient analysis code is reviewed and example of the code application are given

  20. Applications of nano-fluids to enhance LWR accidents management in in-vessel retention and emergency core cooling systems

    International Nuclear Information System (INIS)

    Chupin, A.; Hu, L. W.; Buongiorno, J.

    2008-01-01

    Water-based nano-fluid, colloidal dispersions of nano-particles in water; have been shown experimentally to increase the critical heat flux and surface wettability at very low concentrations. The use of nano-fluids to enhance accidents management would allow either to increase the safe margins in case of severe accidents or to upgrade the power of an existing power plant with constant margins. Building on the initial work, computational fluid dynamics simulations of the nano-fluid injection system have been performed to evaluate the feasibility of a nano-fluid injection system for in-vessel retention application. A preliminary assessment was also conducted on the emergency core cooling system of the European Pressurized Reactor (EPR) to implement a nano-fluid injection system for improving the management of loss of coolant accidents. Several design options were compared/or their respective merits and disadvantages based on criteria including time to injection, safety impact, and materials compatibility. (authors)

  1. Computation of the effect of pipe plasticity on pressure-pulse propagation in a fluid system

    International Nuclear Information System (INIS)

    Youngdahl, C.K.; Kot, C.A.

    1975-04-01

    A simple computational model is developed for incorporating the effect of elastic-plastic deformation of piping on pressure-transient propagation in a fluid system. A computer program (PLWV) is described that incorporates this structural interaction model into a one-dimensional method-of-characteristics procedure for fluid-hammer analysis. Computed results are shown to be in good agreement with available experimental data. The most significant effect of plastic deformation is to limit the peak pressure of a pulse leaving a pipe to approximately the yield pressure of the pipe, if the pipe is sufficiently long. 7 references. (U.S.)

  2. A new fluid distribution system for scale-flexible expanded bed adsorption

    DEFF Research Database (Denmark)

    Hubbuch, Jürgen; Heebøll-Nielsen, Anders; Hobley, Timothy John

    2002-01-01

    of axial dispersion was 6.1 x 10(-6) m(2) (.) s(-1) and 29 theoretical plates were measured. When the rotation rate was raised to 10 rpm, the coefficient of axial dispersion increased to 8.08 x 10(-6) m(2 .) s(-1) and the number of theoretical plates decreased to 22.......A new fluid distribution system designed for expanded bed adsorption was introduced and studied in a 150-cm diameter column. Based on fluid application through a rotating distributor, it eradicates the need for perforated plates, meshes, or local mixers. The effect of rotation rate on column...

  3. Anisotropic generalization of well-known solutions describing relativistic self-gravitating fluid systems. An algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Thirukkanesh, S. [Eastern University, Department of Mathematics, Chenkalady (Sri Lanka); Ragel, F.C. [Eastern University, Department of Physics, Chenkalady (Sri Lanka); Sharma, Ranjan; Das, Shyam [P.D. Women' s College, Department of Physics, Jalpaiguri (India)

    2018-01-15

    We present an algorithm to generalize a plethora of well-known solutions to Einstein field equations describing spherically symmetric relativistic fluid spheres by relaxing the pressure isotropy condition on the system. By suitably fixing the model parameters in our formulation, we generate closed-form solutions which may be treated as an anisotropic generalization of a large class of solutions describing isotropic fluid spheres. From the resultant solutions, a particular solution is taken up to show its physical acceptability. Making use of the current estimate of mass and radius of a known pulsar, the effects of anisotropic stress on the gross physical behaviour of a relativistic compact star is also highlighted. (orig.)

  4. Downhole fluid injection systems, CO2 sequestration methods, and hydrocarbon material recovery methods

    Science.gov (United States)

    Schaef, Herbert T.; McGrail, B. Peter

    2015-07-28

    Downhole fluid injection systems are provided that can include a first well extending into a geological formation, and a fluid injector assembly located within the well. The fluid injector assembly can be configured to inject a liquid CO2/H2O-emulsion into the surrounding geological formation. CO2 sequestration methods are provided that can include exposing a geological formation to a liquid CO2/H2O-emulsion to sequester at least a portion of the CO2 from the emulsion within the formation. Hydrocarbon material recovery methods are provided that can include exposing a liquid CO2/H2O-emulsion to a geological formation having the hydrocarbon material therein. The methods can include recovering at least a portion of the hydrocarbon material from the formation.

  5. System and technique for characterizing fluids using ultrasonic diffraction grating spectroscopy

    Science.gov (United States)

    Greenwood, Margaret S [Richland, WA

    2008-07-08

    A system for determining property of multiphase fluids based on ultrasonic diffraction grating spectroscopy includes a diffraction grating on a solid in contact with the fluid. An interrogation device delivers ultrasound through the solid and a captures a reflection spectrum from the diffraction grating. The reflection spectrum exhibits peaks whose relative size depends on the properties of the various phases of the multiphase fluid. For example, for particles in a liquid, the peaks exhibit dependence on the particle size and the particle volume fraction. Where the exact relationship is know know a priori, data from different peaks of the same reflection spectrum or data from the peaks of different spectra obtained from different diffraction gratings can be used to resolve the size and volume fraction.

  6. Characterization of stratification for an opaque highly stable magnetorheological fluid using vertical axis inductance monitoring system

    Science.gov (United States)

    Xie, Lei; Choi, Young-Tai; Liao, Chang-Rong; Wereley, Norman M.

    2015-05-01

    A key requirement for the commercialization of various magnetorheological fluid (MRF)-based applications is sedimentation stability. In this study, a high viscosity linear polysiloxane (HVLP), which has been used for shock absorbers in heavy equipment, is proposed as a new carrier fluid in highly stable MRFs. The HVLP is known to be a thixotropic (i.e., shear thinning) fluid that shows very high viscosity at very low shear rate and low viscosity at higher shear rate. In this study, using the shear rheometer, the significant thixotropic behavior of the HVLP was experimentally confirmed. In addition, a HVLP carrier fluid-based MRF (HVLP MRF) with 26 vol. % was synthesized and its sedimentation characteristics were experimentally investigated. But, because of the opacity of the HVLP MRF, no mudline can be visually observed. Hence, a vertical axis inductance monitoring system (VAIMS) applied to a circular column of fluid was used to evaluate sedimentation behavior by correlating measured inductance with the volume fraction of dispersed particles (i.e., Fe). Using the VAIMS, Fe concentration (i.e., volume fraction) was monitored for 28 days with a measurement taken every four days, as well as one measurement after 96 days to characterize long-term sedimentation stability. Finally, the concentration of the HVLP MRF as a function of the depth in the column and time, as well as the concentration change versus the depth in the column, are presented and compared with those of a commercially available MRF (i.e., Lord MRF-126CD).

  7. Experience of using heat citric acid disinfection method in central dialysis fluid delivery system.

    Science.gov (United States)

    Sakuma, Koji; Uchiumi, Nobuko; Sato, Sumihiko; Aida, Nobuhiko; Ishimatsu, Taketo; Igoshi, Tadaaki; Kodama, Yoshihiro; Hotta, Hiroyuki

    2010-09-01

    We applied the heat citric acid disinfection method in the main part of the central dialysis fluid delivery system (MPCDDS), which consists of a multiple-patient dialysis fluid supply unit, dialysis console units, and dialysis fluid piping. This disinfection method has been used for single-patient dialysis machines, but this is the first trial in the MPCDDS. We examined, by points of safety and disinfection effect, whether this disinfection method is comparable to conventional disinfection methods in Japan. The conventional disinfection method is a combination of two disinfectants, sodium hypochlorite and acetic acid, used separately for protein removal and decalcification. Consequently, total microbial counts and endotoxin concentrations fully satisfied the microbiological requirements for standard dialysis fluid of ISO 11663. From our results and discussion, this heat citric acid disinfection method is proved to be safe and reliable for MPCDDS. However, to satisfy the microbiological requirements for ultrapure dialysis fluid, further consideration for this method in MPCDDS including the reverse osmosis device composition and piping is necessary.

  8. Experimental Observations of Multiscale Dynamics of Viscous Fluid Behavior: Implications in Volcanic Systems

    Science.gov (United States)

    Arciniega-Ceballos, A.; Spina, L.; Scheu, B.; Dingwell, D. B.

    2015-12-01

    We have investigated the dynamics of Newtonian fluids with viscosities (10-1000 Pa s; corresponding to mafic to intermediate silicate melts) during slow decompression, in a Plexiglas shock tube. As an analogue fluid we used silicon oil saturated with Argon gas for 72 hours. Slow decompression, dropping from 10 MPa to ambient pressure, acts as the excitation mechanism, initiating several processes with their own distinct timescales. The evolution of this multi-timescale phenomenon generates complex non-stationary microseismic signals, which have been recorded with 7 high-dynamic piezoelectric sensors located along the conduit. Correlation analysis of these time series with the associated high-speed imaging enables characterization of distinct phases of the dynamics of these viscous fluids and the extraction of the time and the frequency characteristics of the individual processes. We have identified fluid-solid elastic interaction, degassing, fluid mass expansion and flow, bubble nucleation, growth, coalescence and collapse, foam building and vertical wagging. All these processes (in fine and coarse scales) are sequentially coupled in time, occur within specific pressure intervals, and exhibit a localized distribution in space. Their coexistence and interactions constitute the stress field and driving forces that determine the dynamics of the system. Our observations point to the great potential of this experimental approach in the understanding of volcanic processes and volcanic seismicity.

  9. A variational theory for frictional flow of fluids in inhomogeneous porous systems

    Energy Technology Data Exchange (ETDEWEB)

    Sieniutycz, Stanislaw [Faculty of Chemical Engineering, Warsaw University of Technology, 00-645 Warsaw, 1 Warynskiego Street (Poland)

    2007-04-15

    For nonlinear steady paths of a fluid in an inhomogeneous isotropic porous medium a Fermat-like principle of minimum time is formulated which shows that the fluid streamlines are curved by a location dependent hydraulic conductivity. The principle describes an optimal nature of nonlinear paths in steady Darcy's flows of fluids. An expression for the total resistance of the path leads to a basic analytical formula for an optimal shape of a steady trajectory. In the physical space an optimal curved path ensures the maximum flux or shortest transition time of the fluid through the porous medium. A sort of 'law of bending' holds for the frictional fluid flux in Lagrange coordinates. This law shows that - by minimizing the total resistance - a ray spanned between two given points takes the shape assuring that its relatively large part resides in the region of lower flow resistance (a 'rarer' region of the medium). Analogies and dissimilarities with other systems (e.g. optical or thermal ones) are also discussed. (author)

  10. Coupled particle–fluid transport and magnetic separation in microfluidic systems with passive magnetic functionality

    International Nuclear Information System (INIS)

    Khashan, Saud A; Furlani, Edward P

    2013-01-01

    A study is presented of coupled particle–fluid transport and field-directed particle capture in microfluidic systems with passive magnetic functionality. These systems consist of a microfluidic flow cell on a substrate that contains embedded magnetic elements. Two systems are considered that utilize soft- and hard-magnetic elements, respectively. In the former, an external field is applied to magnetize the elements, and in the latter, they are permanently magnetized. The field produced by the magnetized elements permeates into the flow cell giving rise to an attractive force on magnetic particles that flow through it. The systems are studied using a novel numerical/closed-form modelling approach that combines numerical transport analysis with closed-form field analysis. Particle–fluid transport is computed using computational fluid dynamics (CFD), while the magnetic force that governs particle capture is obtained in closed form. The CFD analysis takes into account dominant particle forces and two-way momentum transfer between the particles and the fluid. The two-way particle–fluid coupling capability is an important feature of the model that distinguishes it from more commonly used and simplified one-way coupling analysis. The model is used to quantify the impact of two-way particle–fluid coupling on both the capture efficiency and the flow pattern in the systems considered. Many effects such as particle-induced flow-enhanced capture efficiency and flow circulation are studied that cannot be predicted using one-way coupling analysis. In addition, dilute particle dispersions are shown to exhibit significant localized particle–fluid coupling near the capture regions, which contradicts the commonly held view that two-way coupling can be ignored when analysing high-gradient magnetic separation involving such particle systems. Overall, the model demonstrates that two-way coupling needs to be taken into account for rigorous predictions of capture efficiency

  11. Piezo Is Essential for Amiloride-Sensitive Stretch-Activated Mechanotransduction in Larval Drosophila Dorsal Bipolar Dendritic Sensory Neurons.

    Science.gov (United States)

    Suslak, Thomas J; Watson, Sonia; Thompson, Karen J; Shenton, Fiona C; Bewick, Guy S; Armstrong, J Douglas; Jarman, Andrew P

    2015-01-01

    Stretch-activated afferent neurons, such as those of mammalian muscle spindles, are essential for proprioception and motor co-ordination, but the underlying mechanisms of mechanotransduction are poorly understood. The dorsal bipolar dendritic (dbd) sensory neurons are putative stretch receptors in the Drosophila larval body wall. We have developed an in vivo protocol to obtain receptor potential recordings from intact dbd neurons in response to stretch. Receptor potential changes in dbd neurons in response to stretch showed a complex, dynamic profile with similar characteristics to those previously observed for mammalian muscle spindles. These profiles were reproduced by a general in silico model of stretch-activated neurons. This in silico model predicts an essential role for a mechanosensory cation channel (MSC) in all aspects of receptor potential generation. Using pharmacological and genetic techniques, we identified the mechanosensory channel, DmPiezo, in this functional role in dbd neurons, with TRPA1 playing a subsidiary role. We also show that rat muscle spindles exhibit a ruthenium red-sensitive current, but found no expression evidence to suggest that this corresponds to Piezo activity. In summary, we show that the dbd neuron is a stretch receptor and demonstrate that this neuron is a tractable model for investigating mechanisms of mechanotransduction.

  12. Fluid Characteristics in the Giant Quartz Reef System of the Bundelkhand Craton, India: Constraints from Fluid Inclusion Study

    Science.gov (United States)

    Rout, D.; Panigrahi, M. K.; Pati, J. K.

    2017-12-01

    Giant quartz reefs are anomalous features indicating extensive mobilization of silica in the crust. Such reefs in the Abitibi belt, Canada and elsewhere are believed to be the result of activity of fluid of diverse sources on terrain boundaries. The Bundelkhand granitoid complex constituting a major part of the Bundelkhnad Craton in north-Central India is traversed by numerous such quartz reefs all across for a length of about 500 km. There are about 20 major reefs having dimensions of 35 to 40 km in length, 50 to 60 m in width standing out as prominent ridges in the region. Almost all are aligned parallel to each other in a sub-vertical to vertical manner following the NE-SW to NNE-SSW trend. Fluid inclusion petrography in quartz from these reefs reveal four types of inclusions viz. aqueous biphase (type-I), pure carbonic (type-II), aqueous carbonic (type-III) and polyphase (type-IV) inclusions. The type-I aqueous biphase inclusions are the dominant type in all the samples studied so far. Salinities calculated from temperature of melting of last ice (Tm) values are low to moderate, ranging from 0.18 to 18.19 wt% NaCl equivalents. Temperature of liquid-vapor homogenization (Th) values of these inclusions show a wide range from 101 ºC to 386 ºC (cluster around 150-250 ºC) essentially into liquid phase ruling out boiling during its course of evolution. Besides, aqueous Biphase inclusions, some data on pure CO2 inclusions furnish a near constant value of TmCO2 at -56.6 ºC in the Bundelkhand Craton indicating absence of CH4. Bivariate plot between Th and salinity suggest three possible water types which are controlling the overall activity of fluid in quartz reefs of Bundelkhand Craton viz. low-T low saline, high-T low saline and moderate-T and moderate saline. A low saline and CO2-bearing and higher temperature nature resembles a metamorphic fluid that may be a source for these giant quartz reefs. The low temperature low-salinity component could be a meteoric

  13. Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects.

    Science.gov (United States)

    Gliemann, Lasse; Rytter, Nicolai; Lindskrog, Mads; Slingsby, Martina H Lundberg; Åkerström, Thorbjörn; Sylow, Lykke; Richter, Erik A; Hellsten, Ylva

    2017-08-15

    Mechanotransduction in endothelial cells is a central mechanism in the regulation of vascular tone and vascular remodelling Mechanotransduction and vascular function may be affected by high sugar levels in plasma because of a resulting increase in oxidative stress and increased levels of advanced glycation end-products (AGE). In healthy young subjects, 2 weeks of daily supplementation with 3 × 75 g of sucrose was found to reduce blood flow in response to passive lower leg movement and in response to 12 W of knee extensor exercise. This vascular impairment was paralleled by up-regulation of platelet endothelial cell adhesion molecule (PECAM)-1, endothelial nitric oxide synthase, NADPH oxidase and Rho family GTPase Rac1 protein expression, an increased basal phosphorylation status of vascular endothelial growth factor receptor 2 and a reduced phosphorylation status of PECAM-1. There were no measurable changes in AGE levels. The findings of the present study demonstrate that daily high sucrose intake markedly affects mechanotransduction proteins and has a detrimental effect on vascular function. Endothelial mechanotransduction is important for vascular function but alterations and activation of vascular mechanosensory proteins have not been investigated in humans. In endothelial cell culture, simple sugars effectively impair mechanosensor proteins. To study mechanosensor- and vascular function in humans, 12 young healthy male subjects supplemented their diet with 3 × 75 g sucrose day -1 for 14 days in a randomized cross-over design. Before and after the intervention period, the hyperaemic response to passive lower leg movement and active knee extensor exercise was determined by ultrasound doppler. A muscle biopsy was obtained from the thigh muscle before and after acute passive leg movement to allow assessment of protein amounts and the phosphorylation status of mechanosensory proteins and NADPH oxidase. The sucrose intervention led to a reduced flow

  14. High-pressure fluid-phase equilibria: Experimental methods and systems investigated (2005-2008)

    DEFF Research Database (Denmark)

    Fonseca, José; Dohrn, Ralf; Peper, Stephanie

    2011-01-01

    %) have carbon dioxide as one of the components. Information on 206 pure components, 535 ternary systems of which 355 (66%) contain carbon dioxide, 163 multicomponent and complex systems, and 207 systems with hydrates is given. A continuation of the review series is planned, covering the years from 2009...... points, the solubility of high-boiling substances in supercritical fluids, the solubility of gases in liquids and the solubility (sorption) of volatile components in polymers are included. Most of experimental data in the literature has been given for binary systems. Of the 1469 binary systems, 796 (54...

  15. Numerical Comparison of NASA's Dual Brayton Power Generation System Performance Using CO2 or N2 as the Working Fluid

    Science.gov (United States)

    Ownens, Albert K.; Lavelle, Thomas M.; Hervol, David S.

    2010-01-01

    A Dual Brayton Power Conversion System (DBPCS) has been tested at the NASA Glenn Research Center using Nitrogen (N2) as the working fluid. This system uses two closed Brayton cycle systems that share a common heat source and working fluid but are otherwise independent. This system has been modeled using the Numerical Propulsion System Simulation (NPSS) environment. This paper presents the results of a numerical study that investigated system performance changes resulting when the working fluid is changed from gaseous (N2) to gaseous carbon dioxide (CO2).

  16. Fluids engineering

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Fluids engineering has played an important role in many applications, from ancient flood control to the design of high-speed compact turbomachinery. New applications of fluids engineering, such as in high-technology materials processing, biotechnology, and advanced combustion systems, have kept up unwaining interest in the subject. More accurate and sophisticated computational and measurement techniques are also constantly being developed and refined. On a more fundamental level, nonlinear dynamics and chaotic behavior of fluid flow are no longer an intellectual curiosity and fluid engineers are increasingly interested in finding practical applications for these emerging sciences. Applications of fluid technology to new areas, as well as the need to improve the design and to enhance the flexibility and reliability of flow-related machines and devices will continue to spur interest in fluids engineering. The objectives of the present seminar were: to exchange current information on arts, science, and technology of fluids engineering; to promote scientific cooperation between the fluids engineering communities of both nations, and to provide an opportunity for the participants and their colleagues to explore possible joint research programs in topics of high priority and mutual interest to both countries. The Seminar provided an excellent forum for reviewing the current state and future needs of fluids engineering for the two nations. With the Seminar ear-marking the first formal scientific exchange between Korea and the United States in the area of fluids engineering, the scope was deliberately left broad and general

  17. Fracture Characterization in Reactive Fluid-Fractured Rock Systems Using Tracer Transport Data

    Science.gov (United States)

    Mukhopadhyay, S.

    2014-12-01

    Fractures, whether natural or engineered, exert significant controls over resource exploitation from contemporary energy sources including enhanced geothermal systems and unconventional oil and gas reserves. Consequently, fracture characterization, i.e., estimating the permeability, connectivity, and spacing of the fractures is of critical importance for determining the viability of any energy recovery program. While some progress has recently been made towards estimating these critical fracture parameters, significant uncertainties still remain. A review of tracer technology, which has a long history in fracture characterization, reveals that uncertainties exist in the estimated parameters not only because of paucity of scale-specific data but also because of knowledge gaps in the interpretation methods, particularly in interpretation of tracer data in reactive fluid-rock systems. We have recently demonstrated that the transient tracer evolution signatures in reactive fluid-rock systems are significantly different from those in non-reactive systems (Mukhopadhyay et al., 2013, 2014). For example, the tracer breakthrough curves in reactive fluid-fractured rock systems are expected to exhibit a long pseudo-state condition, during which tracer concentration does not change by any appreciable amount with passage of time. Such a pseudo-steady state condition is not observed in a non-reactive system. In this paper, we show that the presence of this pseudo-steady state condition in tracer breakthrough patterns in reactive fluid-rock systems can have important connotations for fracture characterization. We show that the time of onset of the pseudo-steady state condition and the value of tracer concentration in the pseudo-state condition can be used to reliably estimate fracture spacing and fracture-matrix interface areas.

  18. Fully coupled thermal-mechanical-fluid flow model for nonliner geologic systems

    International Nuclear Information System (INIS)

    Hart, R.D.

    1981-01-01

    A single model is presented which describes fully coupled thermal-mechanical-fluid flow behavior of highly nonlinear, dynamic or quasistatic, porous geologic systems. The mathematical formulation for the model utilizes the continuum theory of mixtures to describe the multiphase nature of the system, and incremental linear constitutive theory to describe the path dependency of nonlinear material behavior. The model, incorporated in an explicit finite difference numerical procedure, was implemented in two different computer codes. A special-purpose one-dimensional code, SNEAKY, was written for initial validation of the coupling mechanisms and testing of the coupled model logic. A general purpose commercially available code, STEALTH, developed for modeling dynamic nonlinear thermomechanical processes, was modified to include fluid flow behavior and the coupling constitutive model. The fully explicit approach in the coupled calculation facilitated the inclusion of the coupling mechanisms and complex constitutive behavior. Analytical solutions pertaining to consolidation theory for soils, thermoelasticity for solids, and hydrothermal convection theory provided verification of stress and fluid flow, stress and conductive heat transfer, and heat transfer and fluid flow couplings, respectively, in the coupled model. A limited validation of the adequacy of the coupling constitutive assumptions was also performed by comparison with the physical response from two laboratory tests. Finally, the full potential of the coupled model is illustrated for geotechnical applications in energy-resource related areas. Examples in the areas of nuclear waste isolation and cut-and-fill mining are cited

  19. The role of fluid migration system in hydrocarbon accumulation in Maichen Sag, Beibuwan Basin

    Science.gov (United States)

    Liu, Hongyu; Yang, Jinxiu; Wu, Feng; Chen, Wei; Liu, Qianqian

    2018-02-01

    Fluid migration system is of great significance for hydrocarbon accumulation, including the primary migration and secondary migration. In this paper, the fluid migration system is analysed in Maichen Sag using seismic, well logging and core data. Results show that many factors control the hydrocarbon migration process, including hydrocarbon generation and expulsion period from source rocks, microfractures developed in the source rocks, the connected permeable sand bodies, the vertical faults cutting into/through the source rocks and related fault activity period. The spatial and temporal combination of these factors formed an effective network for hydrocarbon expulsion and accumulation, leading to the hydrocarbon reservoir distribution at present. Generally, a better understanding of the hydrocarbon migration system can explain the present status of hydrocarbon distribution, and help select future target zones for oil and gas exploration.

  20. Energy Cost of Avoiding Pressure Oscillations in a Discrete Fluid Power Force System

    DEFF Research Database (Denmark)

    Hansen, Anders Hedegaard; Pedersen, Henrik Clemmensen

    2015-01-01

    In secondary valve controlled discrete fluid power force systems the valve opening trajectory greatly influences the pressure dynamics in the actuator chambers. For discrete fluid power systems featuring hoses of significant length pressure oscillations due to fast valve switching is well......-known. This paper builds upon theoretical findings on how shaping of the valve opening may reduce the cylinder pressure oscillations. The current paper extents the work by implementing the valve opening characteristics reducing the pressure oscillations on a full scale power take-off test-bench for wave energy...... will present measurements comparing pressure dynamics for two valve opening algorithms. In addition the paper will give a theoretical investigation of the energy loss during valve shifting and finally measurements of average power output from the power take-off system in various sea states are compared...

  1. An optimal control method for fluid structure interaction systems via adjoint boundary pressure

    Science.gov (United States)

    Chirco, L.; Da Vià, R.; Manservisi, S.

    2017-11-01

    In recent year, in spite of the computational complexity, Fluid-structure interaction (FSI) problems have been widely studied due to their applicability in science and engineering. Fluid-structure interaction systems consist of one or more solid structures that deform by interacting with a surrounding fluid flow. FSI simulations evaluate the tensional state of the mechanical component and take into account the effects of the solid deformations on the motion of the interior fluids. The inverse FSI problem can be described as the achievement of a certain objective by changing some design parameters such as forces, boundary conditions and geometrical domain shapes. In this paper we would like to study the inverse FSI problem by using an optimal control approach. In particular we propose a pressure boundary optimal control method based on Lagrangian multipliers and adjoint variables. The objective is the minimization of a solid domain displacement matching functional obtained by finding the optimal pressure on the inlet boundary. The optimality system is derived from the first order necessary conditions by taking the Fréchet derivatives of the Lagrangian with respect to all the variables involved. The optimal solution is then obtained through a standard steepest descent algorithm applied to the optimality system. The approach presented in this work is general and could be used to assess other objective functionals and controls. In order to support the proposed approach we perform a few numerical tests where the fluid pressure on the domain inlet controls the displacement that occurs in a well defined region of the solid domain.

  2. Two-fluid equations for a nuclear system with arbitrary motions

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byoung Jae [Chungnam National University, Daejeon (Korea, Republic of); Kim, Kyung Doo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2016-10-15

    Ocean nuclear systems include a seabed-type plant, a floating-type plant, and a nuclear-propulsion ship. We asked ourselves, 'What governing equations should be used for ocean nuclear systems?' Since ocean nuclear systems are apt to move arbitrarily, the two-fluid model must be formulated in the non-inertial frame of reference that is undergoing acceleration with respect to an inertial frame. Two-phase flow systems with arbitrary motions are barely reported. Kim et al. (1996) added the centripetal and Euler acceleration forces to the homogeneous equilibrium momentum equation embedded in the RETRAN code. However, they did not look into the mass and energy equations. The purpose of this study is to derive general two-fluid equations in the non-inertial frame of reference, which can be used for safety analysis of ocean nuclear systems. The two-fluid equation forms for scalar properties such as mass, internal energy, and enthalpy equation in the moving frame are the same as those in the absolute frame. On the other hand, the fictitious effect must be included in the momentum equation.

  3. Development of Fluid and I and C System Design Technology for LMR

    International Nuclear Information System (INIS)

    Kim, S. O.; Sim, Y. S.; Choi, S. K.

    2007-06-01

    The basic concept of fluid and I and C systems of KALIMER-600 was developed and the computer codes required to materialize system concept were also implemented through the R and D program. Based on the analysis results of the design characteristics for the similar reactor types developed in the foreign countries, the system design technologies with adoption of the innovative ideas were developed. With the development, expansion and reinforcement of the methodologies required according to the progress of development and design of the system and the experimental verification of the developed computer code, the excellent and innovative outcomes were produced

  4. Development of Fluid and I and C Systems Design Technology for LMR

    International Nuclear Information System (INIS)

    Kim, Seong O; Sim, Y. S.; Choi, S. K.; Kim, E. K.; Wi, M. H.; Eho, J. H.; Hur, S.; Seong, S. H.; Kim, S. Y.; Jeon, W. D.

    2005-03-01

    The basic concept of fluid and I and C system of KALIMER-600 was developed and the computer codes required to materialize system concept were also implemented through the R and D program. Based on the analysis results of the design characteristics for the similar reactor types developed in a foreign country, the system design technologies with adoption of the innovative ideas were developed. With the development, expansion and reinforcement of the methodologies required according to the progress of development and design of the system and the experimental verification of the developed computer code, the excellent and innovative outcomes were produced

  5. Pressure Feedback in Fluid Power Systems--Active Damping Explained and Exemplified

    DEFF Research Database (Denmark)

    Pedersen, Henrik Clemmensen; Andersen, Torben O.

    2018-01-01

    Fluid power systems are inherently nonlinear and typically suffer from very poor damping. Despite these characteristics, it is not uncommon that traditional linear type controllers are applied. This typically results in conservative adjustment of the controllers, or when more advanced controllers...... a given system, and how to adjust the parameters of the pressure feedback to obtain the best results. This is done for both a traditional symmetric cylinder servo system and a system with a differential cylinder using both pressure and nonpressure compensated proportional valves. Based on the presented...

  6. Cu-As Decoupling in Hydrothermal Systems: A Link Between Pyrite Chemistry and Fluid Composition

    Science.gov (United States)

    Reich, M.; Tardani, D.; Deditius, A.; Chryssoulis, S.; Wrage, J.; Sanchez-Alfaro, P.; Andrea, H.; Cinthia, J.

    2016-12-01

    Chemical zonations in pyrite have been recognized in most hydrothermal ore deposit types, showing in some cases marked oscillatory alternation of metals and metalloids in pyrite growth zones (e.g., of Cu-rich, As-(Au)-depleted zones and As-(Au)-rich, Cu-depleted zones). This decoupled geochemical behavior of Cu and As has been interpreted as a result of chemical changes in ore-forming fluids, although direct evidence connecting fluctuations in hydrothermal fluid composition with metal partitioning into pyrite growth zones is still lacking. Here we report a comprehensive trace element database of pyrite from an active hydrothermal system, the Tolhuaca Geothermal System (TGS) in southern Chile. We combined high-spatial resolution and X-ray mapping capabilities of electron microprobe analysis (EMPA) with low detection limits and depth-profiling capabilities of secondary-ion mass spectrometry (SIMS) in a suite of pyrite samples retrieved from a 1 km drill hole that crosses the argillic and propylitic alteration zones of the geothermal system. We show that the concentrations of precious metals (e.g., Au, Ag), metalloids (e.g., As, Sb, Se, Te), and base and heavy metals (e.g., Cu, Co, Ni, Pb) in pyrite at the TGS are significant. Among the elements analyzed, arsenic, Cu and Co are the most abundant with concentrations that vary from sub-ppm levels to a few wt. %. Pyrites from the deeper propylitic zone do not show significant zonation and high Cu-(Co)-As concentrations correlate with each other. In contrast, well-developed zonations were detected in pyrite from the shallow argillic alteration zone, where Cu(Co)-rich, As-depleted cores alternate with Cu(Co)-depleted, As-rich rims. These microanalytical data were contrasted with chemical data of fluid inclusion in quartz veins (high Cu/Na and low As/Na) and borehole fluids (low Cu/Na and high As/Na) reported at the TGS, showing a clear correspondence between Cu and As concentrations in pyrite-forming fluids and chemical

  7. Fluid-structure interaction in non-rigid pipeline systems - large scale validation experiments

    International Nuclear Information System (INIS)

    Heinsbroek, A.G.T.J.; Kruisbrink, A.C.H.

    1993-01-01

    The fluid-structure interaction computer code FLUSTRIN, developed by DELFT HYDRAULICS, enables the user to determine dynamic fluid pressures, structural stresses and displacements in a liquid-filled pipeline system under transient conditions. As such, the code is a useful tool to process and mechanical engineers in the safe design and operation of pipeline systems in nuclear power plants. To validate FLUSTRIN, experiments have been performed in a large scale 3D test facility. The test facility consists of a flexible pipeline system which is suspended by wires, bearings and anchors. Pressure surges, which excite the system, are generated by a fast acting shut-off valve. Dynamic pressures, structural displacements and strains (in total 70 signals) have been measured under well determined initial and boundary conditions. The experiments have been simulated with FLUSTRIN, which solves the acoustic equations using the method of characteristics (fluid) and the finite element method (structure). The agreement between experiments and simulations is shown to be good: frequencies, amplitudes and wave phenomena are well predicted by the numerical simulations. It is demonstrated that an uncoupled water hammer computation would render unreliable and useless results. (author)

  8. Scaling of two-phase flow transients using reduced pressure system and simulant fluid

    International Nuclear Information System (INIS)

    Kocamustafaogullari, G.; Ishii, M.

    1987-01-01

    Scaling criteria for a natural circulation loop under single-phase flow conditions are derived. Based on these criteria, practical applications for designing a scaled-down model are considered. Particular emphasis is placed on scaling a test model at reduced pressure levels compared to a prototype and on fluid-to-fluid scaling. The large number of similarty groups which are to be matched between modell and prototype makes the design of a scale model a challenging tasks. The present study demonstrates a new approach to this clasical problen using two-phase flow scaling parameters. It indicates that a real time scaling is not a practical solution and a scaled-down model should have an accelerated (shortened) time scale. An important result is the proposed new scaling methodology for simulating pressure transients. It is obtained by considerung the changes of the fluid property groups which appear within the two-phase similarity parameters and the single-phase to two-phase flow transition prameters. Sample calculations are performed for modeling two-phase flow transients of a high pressure water system by a low-pressure water system or a Freon system. It is shown that modeling is possible for both cases for simulation pressure transients. However, simulation of phase change transitions is not possible by a reduced pressure water system without distortion in either power or time. (orig.)

  9. Adaptive fluid lens and sunlight redirection system : exploring a novel way of redirecting and altering sunlight in large span roofs

    NARCIS (Netherlands)

    Heinzelmann, F.; Bristogianni, T.; Teuffel, P.; Stouffs, R.; Sariyildiz, S.

    2013-01-01

    The paper describes a novel system to alter and redirect sunlight under large span roofs with the help of a fluid lens system. Focus lies on the computational design, testing, measurement and evaluation of the performance of a physical prototype.

  10. Research into the Physiology of Cerebrospinal Fluid Reaches a New Horizon: Intimate Exchange between Cerebrospinal Fluid and Interstitial Fluid May Contribute to Maintenance of Homeostasis in the Central Nervous System.

    Science.gov (United States)

    Matsumae, Mitsunori; Sato, Osamu; Hirayama, Akihiro; Hayashi, Naokazu; Takizawa, Ken; Atsumi, Hideki; Sorimachi, Takatoshi

    2016-07-15

    Cerebrospinal fluid (CSF) plays an essential role in maintaining the homeostasis of the central nervous system. The functions of CSF include: (1) buoyancy of the brain, spinal cord, and nerves; (2) volume adjustment in the cranial cavity; (3) nutrient transport; (4) protein or peptide transport; (5) brain volume regulation through osmoregulation; (6) buffering effect against external forces; (7) signal transduction; (8) drug transport; (9) immune system control; (10) elimination of metabolites and unnecessary substances; and finally (11) cooling of heat generated by neural activity. For CSF to fully mediate these functions, fluid-like movement in the ventricles and subarachnoid space is necessary. Furthermore, the relationship between the behaviors of CSF and interstitial fluid in the brain and spinal cord is important. In this review, we will present classical studies on CSF circulation from its discovery over 2,000 years ago, and will subsequently introduce functions that were recently discovered such as CSF production and absorption, water molecule movement in the interstitial space, exchange between interstitial fluid and CSF, and drainage of CSF and interstitial fluid into both the venous and the lymphatic systems. Finally, we will summarize future challenges in research. This review includes articles published up to February 2016.

  11. Fluid dynamics of acoustic and hydrodynamic cavitation in hydraulic power systems

    OpenAIRE

    Ferrari, A.

    2017-01-01

    Cavitation is the transition from a liquid to a vapour phase, due to a drop in pressure to the level of the vapour tension of the fluid. Two kinds of cavitation have been reviewed here: acoustic cavitation and hydrodynamic cavitation. As acoustic cavitation in engineering systems is related to the propagation of waves through a region subjected to liquid vaporization, the available expressions of the sound speed are discussed. One of the main effects of hydrodynamic cavitation in the nozzles ...

  12. Application of Modelling and Simulation in Mechatronics and Fluid Power System Design - Education and Research

    DEFF Research Database (Denmark)

    Andersen, T. O.; Hansen, M. R.; Conrad, Finn

    2003-01-01

    The development within the engineering industry is ever more in the direction of an integration of electronics both on the component level and system level. This implies improved and more intelligentcomponents with increased funtionality at the same time as the variant creation is made in the ele...... and control can be useful in analysis, synthesis, design and application of mechatronic systems with fluid power actuation. The focus is on system aspects and describes several projects from education and research that utilises the mentioned methods and techniques....

  13. Systems and methods for the detection of low-level harmful substances in a large volume of fluid

    Science.gov (United States)

    Carpenter, Michael V.; Roybal, Lyle G.; Lindquist, Alan; Gallardo, Vincente

    2016-03-15

    A method and device for the detection of low-level harmful substances in a large volume of fluid comprising using a concentrator system to produce a retentate and analyzing the retentate for the presence of at least one harmful substance. The concentrator system performs a method comprising pumping at least 10 liters of fluid from a sample source through a filter. While pumping, the concentrator system diverts retentate from the filter into a container. The concentrator system also recirculates at least part of the retentate in the container again through the filter. The concentrator system controls the speed of the pump with a control system thereby maintaining a fluid pressure less than 25 psi during the pumping of the fluid; monitors the quantity of retentate within the container with a control system, and maintains a reduced volume level of retentate and a target volume of retentate.

  14. Appplication of a general fluid mechanics program to NTP system modeling

    International Nuclear Information System (INIS)

    Lee, S.K.

    1993-01-01

    An effort is currently underway at NASA and the Department of Energy (DOE) to develop an accurate model for predicting nuclear thermal propulsion (NTP) system performance. The objective of the effort is to develop several levels of computer programs which vary in detail and complexity according to user's needs. The current focus is on the Level 1 steady-state, parametric system model. This system model will combine a general fluid mechanics program, SAFSIM, with the ability to analyze turbines, pumps, nozzles, and reactor physics. SAFSIM (System Analysis Flow SIMulator) is a FORTRAN computer program that simulates integrated performance of systems involving fluid mechanics, heat transfer, and reactor dynamics. SAFSIM has the versatility to allow simulation of almost any system, including a nuclear reactor system. The focus of this paper is the validation of SAFSIM's capabilities as a base computational engine for a nuclear thermal propulsion system model. Validation is being accomplished by modeling of a nuclear engine test using SAFSIM and comparing the results to known experimental data

  15. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.

    Science.gov (United States)

    Aspelund, Aleksanteri; Antila, Salli; Proulx, Steven T; Karlsen, Tine Veronica; Karaman, Sinem; Detmar, Michael; Wiig, Helge; Alitalo, Kari

    2015-06-29

    The central nervous system (CNS) is considered an organ devoid of lymphatic vasculature. Yet, part of the cerebrospinal fluid (CSF) drains into the cervical lymph nodes (LNs). The mechanism of CSF entry into the LNs has been unclear. Here we report the surprising finding of a lymphatic vessel network in the dura mater of the mouse brain. We show that dural lymphatic vessels absorb CSF from the adjacent subarachnoid space and brain interstitial fluid (ISF) via the glymphatic system. Dural lymphatic vessels transport fluid into deep cervical LNs (dcLNs) via foramina at the base of the skull. In a transgenic mouse model expressing a VEGF-C/D trap and displaying complete aplasia of the dural lymphatic vessels, macromolecule clearance from the brain was attenuated and transport from the subarachnoid space into dcLNs was abrogated. Surprisingly, brain ISF pressure and water content were unaffected. Overall, these findings indicate that the mechanism of CSF flow into the dcLNs is directly via an adjacent dural lymphatic network, which may be important for the clearance of macromolecules from the brain. Importantly, these results call for a reexamination of the role of the lymphatic system in CNS physiology and disease. © 2015 Aspelund et al.

  16. Development of fluid I and C systems design technology for LMR

    International Nuclear Information System (INIS)

    Sim, Yoon Sub; Kim, S. O.; Kim, Y. S.

    2002-04-01

    LMR can make the utilization of the uranium resources much more efficiently and reduce the storage load of high level nuclear waste but the technology for designing the systems of LMR was not secured domestically. Based on this technical requirement, research was made for the LMR system technology and a conceptual design for the fluid and IC systems for the LMR was developed and established. Also required computer code systems for the analysis and design of the systems were developed. Design requirements for each system were revised, analysis was made for various system design features, performance, sodium-water reaction, and operation stability. The developed codes were verified against experimental data produced locally and acquired through international cooperation

  17. Copper-arsenic decoupling in an active geothermal system: A link between pyrite and fluid composition

    Science.gov (United States)

    Tardani, Daniele; Reich, Martin; Deditius, Artur P.; Chryssoulis, Stephen; Sánchez-Alfaro, Pablo; Wrage, Jackie; Roberts, Malcolm P.

    2017-05-01

    Over the past few decades several studies have reported that pyrite hosts appreciable amounts of trace elements which commonly occur forming complex zoning patterns within a single mineral grain. These chemical zonations in pyrite have been recognized in a variety of hydrothermal ore deposit types (e.g., porphyry Cu-Mo-Au, epithermal Au deposits, iron oxide-copper-gold, Carlin-type and Archean lode Au deposits, among others), showing, in some cases, marked oscillatory alternation of metals and metalloids in pyrite growth zones (e.g., of Cu-rich, As-(Au, Ag)-depleted zones and As-(Au, Ag)-rich, Cu-depleted zones). This decoupled geochemical behavior of Cu and As has been interpreted as a result of chemical changes in ore-forming fluids, although direct evidence connecting fluctuations in hydrothermal fluid composition with metal partitioning into pyrite growth zones is still lacking. In this study, we report a comprehensive trace element database of pyrite from the Tolhuaca Geothermal System (TGS) in southern Chile, a young and active hydrothermal system where fewer pyrite growth rims and mineralization events are present and the reservoir fluid (i.e. ore-forming fluid) is accessible. We combined the high-spatial resolution and X-ray mapping capabilities of electron microprobe analysis (EMPA) with low detection limits and depth-profiling capacity of secondary-ion mass spectrometry (SIMS) in a suite of pyrite samples retrieved from a ∼1 km drill hole that crosses the argillic (20-450 m) and propylitic (650-1000 m) alteration zones of the geothermal system. We show that the concentrations of precious metals (e.g., Au, Ag), metalloids (e.g., As, Sb, Se, Te), and base and heavy metals (e.g., Cu, Co, Ni, Pb) in pyrite at the TGS are significant. Among the elements analyzed, As and Cu are the most abundant with concentrations that vary from sub-ppm levels to a few wt.% (i.e., up to ∼5 wt.% As, ∼1.5 wt.% Cu). Detailed wavelength-dispersive spectrometry (WDS) X

  18. Endothelial mechanotransduction proteins and vascular function are altered by dietary sucrose supplementation in healthy young male subjects

    DEFF Research Database (Denmark)

    Gliemann, Lasse; Rytter, Nicolai; Lindskrog, Mads

    2017-01-01

    Endothelial mechanotransduction is important for vascular function but alterations and activation of vascular mechanosensory proteins have not been investigated in humans. In endothelial cell culture, simple sugars effectively impair mechanosensor proteins. To study mechanosensor- and vascular...... by ultrasound doppler. A muscle biopsy was obtained from the thigh muscle before and after acute passive leg movement, to asses the protein amount and phosphorylation status of mechanosensory proteins and NADPH oxidase. The sucrose intervention led to a reduced flow response to passive movement (by 17 ± 2...... %) and to 12 watts of active exercise (by 9 ± 1 %), indicating impaired vascular function. Reduced flow response to passive and active exercise was paralleled by a significant upregulation of Platelet endothelial cell adhesion molecule (PECAM-1), endothelial nitric oxide synthase, NADPH oxidase and the Rho...

  19. Dynamic analysis of an accelerator-driven fluid-fueled subcritical radioactive waste burning system

    International Nuclear Information System (INIS)

    Woosley, M.L. Jr.; Rydin, R.A.

    1998-01-01

    The recent revival of interest in accelerator-driven subcritical fluid-fueled systems is documented. Several important applications of these systems are mentioned, and this is used to motivate the need for dynamic analysis of the nuclear kinetics of such systems. A physical description of the Los alamos National Laboratory accelerator-based conversion (ABC) concept is provided. This system is used as the basis for the kinetics study in this research. The current approach to the dynamic simulation of an accelerator-driven subcritical fluid-fueled system includes four functional elements: a discrete ordinates model is used to calculate the flux distribution for the source-driven system; a nodal convection model is used to calculate time-dependent isotope and temperature distributions that impact reactivity; a nodal importance weighting model is used to calculate the reactivity impact of temperature and isotope distributions and to feed this information back to the time-dependent nodal convection model; and a transient driver is used to simulate transients, model the balance of plant, and record simulation data. Specific transients that have been analyzed with the current modeling system are discussed. These transients include loss-of-flow and loss-of-cooling accidents, xenon and samarium transients, and cold-plug and overfueling events. The results of various transients have uncovered unpredictable behavior, unresolved design issues, and the need for active control. The need for the development of a nodal-coupling spatial kinetics model is mentioned

  20. Acceleration of coupled granular flow and fluid flow simulations in pebble bed energy systems

    International Nuclear Information System (INIS)

    Li, Yanheng; Ji, Wei

    2013-01-01

    Highlights: ► Fast simulation of coupled pebble flow and coolant flow in PBR systems is studied. ► Dimension reduction based on axisymmetric geometry shows significant speedup. ► Relaxation of coupling frequency is investigated and an optimal range is determined. ► A total of 80% efficiency increase is achieved by the two fast strategies. ► Fast strategies can be applied to simulating other general fluidized bed systems. -- Abstract: Fast and accurate approaches to simulating the coupled particle flow and fluid flow are of importance to the analysis of large particle-fluid systems. This is especially needed when one tries to simulate pebble flow and coolant flow in Pebble Bed Reactor (PBR) energy systems on a routine basis. As one of the Generation IV designs, the PBR design is a promising nuclear energy system with high fuel performance and inherent safety. A typical PBR core can be modeled as a particle-fluid system with strong interactions among pebbles, coolants and reactor walls. In previous works, the coupled Discrete Element Method (DEM)-Computational Fluid Dynamics (CFD) approach has been investigated and applied to modeling PBR systems. However, the DEM-CFD approach is computationally expensive due to large amounts of pebbles in PBR systems. This greatly restricts the PBR analysis for the real time prediction and inclusion of more physics. In this work, based on the symmetry of the PBR geometry and the slow motion characteristics of the pebble flow, two acceleration strategies are proposed. First, a simplified 3D-DEM/2D-CFD approach is proposed to speed up the DEM-CFD simulation without loss of accuracy. Pebble flow is simulated by a full 3D DEM, while the coolant flow field is calculated with a 2D CFD simulation by averaging variables along the annular direction in the cylindrical and annular geometries. Second, based on the slow motion of pebble flow, the impact of the coupling frequency on the computation accuracy and efficiency is

  1. Acceleration of coupled granular flow and fluid flow simulations in pebble bed energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yanheng, E-mail: liy19@rpi.edu [Department of Mechanical, Aerospace, and Nuclear Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY (United States); Ji, Wei, E-mail: jiw2@rpi.edu [Department of Mechanical, Aerospace, and Nuclear Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY (United States)

    2013-05-15

    Highlights: ► Fast simulation of coupled pebble flow and coolant flow in PBR systems is studied. ► Dimension reduction based on axisymmetric geometry shows significant speedup. ► Relaxation of coupling frequency is investigated and an optimal range is determined. ► A total of 80% efficiency increase is achieved by the two fast strategies. ► Fast strategies can be applied to simulating other general fluidized bed systems. -- Abstract: Fast and accurate approaches to simulating the coupled particle flow and fluid flow are of importance to the analysis of large particle-fluid systems. This is especially needed when one tries to simulate pebble flow and coolant flow in Pebble Bed Reactor (PBR) energy systems on a routine basis. As one of the Generation IV designs, the PBR design is a promising nuclear energy system with high fuel performance and inherent safety. A typical PBR core can be modeled as a particle-fluid system with strong interactions among pebbles, coolants and reactor walls. In previous works, the coupled Discrete Element Method (DEM)-Computational Fluid Dynamics (CFD) approach has been investigated and applied to modeling PBR systems. However, the DEM-CFD approach is computationally expensive due to large amounts of pebbles in PBR systems. This greatly restricts the PBR analysis for the real time prediction and inclusion of more physics. In this work, based on the symmetry of the PBR geometry and the slow motion characteristics of the pebble flow, two acceleration strategies are proposed. First, a simplified 3D-DEM/2D-CFD approach is proposed to speed up the DEM-CFD simulation without loss of accuracy. Pebble flow is simulated by a full 3D DEM, while the coolant flow field is calculated with a 2D CFD simulation by averaging variables along the annular direction in the cylindrical and annular geometries. Second, based on the slow motion of pebble flow, the impact of the coupling frequency on the computation accuracy and efficiency is

  2. Near-surface gravity actuated pipe (GAP{sup TM}) system for Brazilian deepwater fluid transfer

    Energy Technology Data Exchange (ETDEWEB)

    Fromage, Lionel; Brown, Paul A. [SBM Offshore (Monaco)

    2009-12-19

    The recent discovery of new deep water and ultra-deep water oil and gas fields offshore Brazil, including pre-salt reservoirs, has become a focal point for field development Operators and Contractors. The aggressive nature of fluids (sour, high density) in combination with deeper waters implies potential flow assurance issues. These issues challenge riser and pipeline technology to find cost effective solutions for hydrocarbon fluid transfer in field development scenarios involving phased tied-back. The near-surface GAP{sup TM}, system (Gravity Actuated Pipe{sup TM}), which has been in operation for more than two years on the Kikeh field offshore Malaysia in 1325 m of water between a Dry Tree Unit (SPAR) and a turret-moored FPSO, is considered to meet these challenges since such a product is quasi independent of water depth and takes advantage of being near surface to optimize flow assurance. Furthermore the GAP{sup TM} has undergone technical upgrades when compared to the Kikeh project in order to make it suitable for the more hostile met ocean conditions offshore Brazil. This paper presents the design features, the construction and assembly plans in Brazil and the offshore installation of a GAP fluid transfer system for operation in Brazilian deep waters. (author)

  3. [Imbalance of system of glutamin - glutamic acid in the placenta and amniotic fluid at placental insufficiency].

    Science.gov (United States)

    Pogorelova, T N; Gunko, V O; Linde, V A

    2014-01-01

    Metabolism of glutamine and glutamic acid has been investigated in the placenta and amniotic fluid under conditions of placental insufficiency. The development of placental insufficiency is characterized by the increased content of glutamic acid and a decrease of glutamine in both placenta and amniotic fluid. These changes changes were accompanied by changes in the activity of enzymes involved in the metabolism of these amino acids. There was a decrease in glutamate dehydrogenase activity and an increase in glutaminase activity with the simultaneous decrease of glutamine synthetase activity. The compensatory decrease in the activity of glutamine keto acid aminotransferase did not prevent a decrease in the glutamine level. The impairments in the system glutamic acid-glutamine were more pronounced during the development of premature labor.

  4. Acoustically Driven Fluid and Particle Motion in Confined and Leaky Systems

    Science.gov (United States)

    Barnkob, Rune; Nama, Nitesh; Ren, Liqiang; Huang, Tony Jun; Costanzo, Francesco; Kähler, Christian J.

    2018-01-01

    The acoustic motion of fluids and particles in confined and acoustically leaky systems is receiving increasing attention for its use in medicine and biotechnology. A number of contradicting physical and numerical models currently exist, but their validity is uncertain due to the unavailability of hard-to-access experimental data for validation. We provide experimental benchmarking data by measuring 3D particle trajectories and demonstrate that the particle trajectories can be described numerically without any fitting parameter by a reduced-fluid model with leaky impedance-wall conditions. The results reveal the hitherto unknown existence of a pseudo-standing wave that drives the acoustic streaming as well as the acoustic radiation force on suspended particles.

  5. Pumped Fluid Loop Heat Rejection and Recovery Systems for Thermal Control of the Mars Science Laboratory

    Science.gov (United States)

    Bhandari, Pradeep; Birur, Gajanana; Prina, Mauro; Ramirez, Brenda; Paris, Anthony; Novak, Keith; Pauken, Michael

    2006-01-01

    This viewgraph presentation reviews the heat rejection and heat recovery system for thermal control of the Mars Science Laboratory (MSL). The MSL mission will use mechanically pumped fluid loop based architecture for thermal control of the spacecraft and rover. The architecture is designed to harness waste heat from an Multi Mission Radioisotope Thermo-electric Generator (MMRTG) during Mars surface operations for thermal control during cold conditions and also reject heat during the cruise aspect of the mission. There are several test that are being conducted that will insure the safety of this concept. This architecture can be used during any future interplanetary missions utilizing radioisotope power systems for power generation.

  6. A Novel Approach for Modeling Chemical Reaction in Generalized Fluid System Simulation Program

    Science.gov (United States)

    Sozen, Mehmet; Majumdar, Alok

    2002-01-01

    The Generalized Fluid System Simulation Program (GFSSP) is a computer code developed at NASA Marshall Space Flight Center for analyzing steady state and transient flow rates, pressures, temperatures, and concentrations in a complex flow network. The code, which performs system level simulation, can handle compressible and incompressible flows as well as phase change and mixture thermodynamics. Thermodynamic and thermophysical property programs, GASP, WASP and GASPAK provide the necessary data for fluids such as helium, methane, neon, nitrogen, carbon monoxide, oxygen, argon, carbon dioxide, fluorine, hydrogen, water, a hydrogen, isobutane, butane, deuterium, ethane, ethylene, hydrogen sulfide, krypton, propane, xenon, several refrigerants, nitrogen trifluoride and ammonia. The program which was developed out of need for an easy to use system level simulation tool for complex flow networks, has been used for the following purposes to name a few: Space Shuttle Main Engine (SSME) High Pressure Oxidizer Turbopump Secondary Flow Circuits, Axial Thrust Balance of the Fastrac Engine Turbopump, Pressurized Propellant Feed System for the Propulsion Test Article at Stennis Space Center, X-34 Main Propulsion System, X-33 Reaction Control System and Thermal Protection System, and International Space Station Environmental Control and Life Support System design. There has been an increasing demand for implementing a combustion simulation capability into GFSSP in order to increase its system level simulation capability of a liquid rocket propulsion system starting from the propellant tanks up to the thruster nozzle for spacecraft as well as launch vehicles. The present work was undertaken for addressing this need. The chemical equilibrium equations derived from the second law of thermodynamics and the energy conservation equation derived from the first law of thermodynamics are solved simultaneously by a Newton-Raphson method. The numerical scheme was implemented as a User

  7. Relaxation and self-organization in two-dimensional plasma and neutral fluid flow systems

    International Nuclear Information System (INIS)

    Das, Amita

    2008-01-01

    Extensive numerical studies in the framework of a simplified two-dimensional model for neutral and plasma fluid for a variety of initial configurations and for both decaying and driven cases are carried out to illustrate relaxation toward a self-organized state. The dynamical model equation constitutes a simple choice for this purpose, e.g., the vorticity equation of the Navier-Stokes dynamics for the incompressible neutral fluids and the Hasegawa-Mima equation for plasma fluid flow system. Scatter plots are employed to observe a development of functional relationship, if any, amidst the generalized vorticity and its Laplacian. It is seen that they do not satisfy a linear relationship as the well known variational approach of enstrophy minimization subject to constancy of the energy integral for the two-dimensional (2D) system suggests. The observed nonlinear functional relationship is understood by separating the contribution to the scatter plot from spatial regions with intense vorticity patches and those of the background flow region where the background vorticity is weak or absent altogether. It is shown that such a separation has close connection with the known exact analytical solutions of the system. The analytical solutions are typically obtained by assuming a finite source of vorticity for the inner core of the localized structure, which is then matched with the solution in the outer region where vorticity is chosen to be zero. The work also demonstrates that the seemingly ad hoc choice of the linear vorticity source function for the inner region is in fact consistent with the self-organization paradigm of the 2D systems

  8. Enhanced Geothermal Systems Research and Development: Models of Subsurface Chemical Processes Affecting Fluid Flow

    Energy Technology Data Exchange (ETDEWEB)

    Moller, Nancy; Weare J. H.

    2008-05-29

    Successful exploitation of the vast amount of heat stored beneath the earth’s surface in hydrothermal and fluid-limited, low permeability geothermal resources would greatly expand the Nation’s domestic energy inventory and thereby promote a more secure energy supply, a stronger economy and a cleaner environment. However, a major factor limiting the expanded development of current hydrothermal resources as well as the production of enhanced geothermal systems (EGS) is insufficient knowledge about the chemical processes controlling subsurface fluid flow. With funding from past grants from the DOE geothermal program and other agencies, we successfully developed advanced equation of state (EOS) and simulation technologies that accurately describe the chemistry of geothermal reservoirs and energy production processes via their free energies for wide XTP ranges. Using the specific interaction equations of Pitzer, we showed that our TEQUIL chemical models can correctly simulate behavior (e.g., mineral scaling and saturation ratios, gas break out, brine mixing effects, down hole temperatures and fluid chemical composition, spent brine incompatibilities) within the compositional range (Na-K-Ca-Cl-SO4-CO3-H2O-SiO2-CO2(g)) and temperature range (T < 350°C) associated with many current geothermal energy production sites that produce brines with temperatures below the critical point of water. The goal of research carried out under DOE grant DE-FG36-04GO14300 (10/1/2004-12/31/2007) was to expand the compositional range of our Pitzer-based TEQUIL fluid/rock interaction models to include the important aluminum and silica interactions (T < 350°C). Aluminum is the third most abundant element in the earth’s crust; and, as a constituent of aluminosilicate minerals, it is found in two thirds of the minerals in the earth’s crust. The ability to accurately characterize effects of temperature, fluid mixing and interactions between major rock-forming minerals and hydrothermal and

  9. Design and simulation of a new bidirectional actuator for haptic systems featuring MR fluid

    Science.gov (United States)

    Hung, Nguyen Quoc; Tri, Diep Bao; Cuong, Vo Van; Choi, Seung-Bok

    2017-04-01

    In this research, a new configuration of bidirectional actuator featuring MR fluid (BMRA) is proposed for haptic application. The proposed BMRA consists of a driving disc, a driving housing and a driven disc. The driving disc is placed inside the driving housing and rotates counter to each other by a servo DC motor and a bevel gear system. The driven shaft is also placed inside the housing and next to the driving disc. The gap between the two disc and the gap between the discs and the housing are filled with MR fluid. On the driven disc, two mutual magnetic coils are placed. By applying currents to the two coils mutually, the torque at the output shaft, which is fixed to the driven disc, can be controlled with positive, zero or negative value. This make the actuator be suitable for haptic application. After a review of MR fluid and its application, configuration of the proposed BMRA is presented. The modeling of the actuator is then derived based on Bingham rheological model of MRF and magnetic finite element analysis (FEA). The optimal design of the actuator is then performed to minimize the mass of the BMRA. From the optimal design result, performance characteristics of the actuator is simulated and detailed design of a prototype actuator is conducted.

  10. Experimental evaluation of a non-azeotropic working fluid for geothermal heat pump system

    International Nuclear Information System (INIS)

    Zhao, L.

    2004-01-01

    Geothermal energy resources are found in many countries. A reasonable and efficient utilization of these resources has been a worldwide concern. The application of geothermal heat pump systems (GHPS) can help increase the efficiency of using geothermal energy and reduce the thermal pollution to the earth surface. However, this is only possible with a proper working fluid. In this paper, a non-azeotropic working fluid (R290/R600a/R123) is presented for a GHPS where geothermal water at 40-45 deg. C and heating network water at 70-80 deg. C serve as the low and high temperature heat sources. Experimental results show that the coefficient of performance (COP) of a GHPS using the working fluid is above 3.5 with the condensation temperature above 80 deg. C and the condensation pressure below 18 bar, while the temperature of the geothermal water is reduced from 40-46 deg. C to 31-36 deg. C

  11. a New ER Fluid Based Haptic Actuator System for Virtual Reality

    Science.gov (United States)

    Böse, H.; Baumann, M.; Monkman, G. J.; Egersdörfer, S.; Tunayar, A.; Freimuth, H.; Ermert, H.; Khaled, W.

    The concept and some steps in the development of a new actuator system which enables the haptic perception of mechanically inhomogeneous virtual objects are introduced. The system consists of a two-dimensional planar array of actuator elements containing an electrorheological (ER) fluid. When a user presses his fingers onto the surface of the actuator array, he perceives locally variable resistance forces generated by vertical pistons which slide in the ER fluid through the gaps between electrode pairs. The voltage in each actuator element can be individually controlled by a novel sophisticated switching technology based on optoelectric gallium arsenide elements. The haptic information which is represented at the actuator array can be transferred from a corresponding sensor system based on ultrasonic elastography. The combined sensor-actuator system may serve as a technology platform for various applications in virtual reality, like telemedicine where the information on the consistency of tissue of a real patient is detected by the sensor part and recorded by the actuator part at a remote location.

  12. Binary blend of carbon dioxide and fluoro ethane as working fluid in transcritical heat pump systems

    Directory of Open Access Journals (Sweden)

    Zhang Xian-Ping

    2015-01-01

    Full Text Available As an eco-friendly working fluid, carbon dioxide or R744 is expected to substitute for the existing working fluids used in heat pump systems. It is, however, challenged by the much higher heat rejection pressure in transcritical cycle compared with the traditional subcritical cycle using freons. There exists a worldwide tendency to utilize blend refrigerants as alternatives. Therefore, a new binary blend R744/R161 in this research is proposed in order to decrease the heat rejection pressure. Meanwhile, on mixing R744 with R161, the flammability and explosivity of R161 can be suppressed because of the extinguishing effect of R744. A transcritical thermodynamic model is developed, and then the system performances of heat pump using R744/R161 blend are investigated and compared with those of pure R744 system under the same operation conditions. The variations of heat rejection pressure, heating coefficient of performance, unit volumetric heating capacity, discharge temperature of compressor and the mass fraction of R744/R161 are researched. The results show that R744/R161 mixture can reduce the heat rejection pressure of transcritical heat pump system.

  13. Cooling Systems Design in Hot Stamping Tools by a Thermal-Fluid-Mechanical Coupled Approach

    Directory of Open Access Journals (Sweden)

    Tao Lin

    2014-06-01

    Full Text Available Hot stamping tools with cooling systems are the key facilities for hot stamping process of Ultrahigh strength steels (UHSS in automotive industry. Hot stamping tools have significant influence on the final microstructure and properties of the hot stamped parts. In serials production, the tools should be rapidly cooled by cooling water. Hence, design of hot stamping tools with cooling systems is important not only for workpieces of good quality but also for the tools with good cooling performance and long life. In this paper, a new multifield simulation method was proposed for the design of hot stamping tools with cooling system. The deformation of the tools was also analyzed by this method. Based on MpCCI (Mesh-based parallel Code Coupling Interface, thermal-fluid simulation and thermal-fluid-mechanical coupled simulation were performed. Subsequently, the geometrical parameters of the cooling system are investigated for the design. The results show that, both the distance between the ducts and the distance between the ducts and the tools loaded contour have significant influence on the quenching effect. And better quenching effect can be achieved with the shorter distance from the tool surface and with smaller distance between ducts. It is also shown that, thermal expansion is the main reason for deformation of the hot forming tools, which causes the distortion of the cooling ducts, and the stress concentration at corner of the ducts.

  14. Investigation of fluid flow in various geometries related to nuclear reactor using PIV system

    International Nuclear Information System (INIS)

    Kansal, A.K.; Maheshwari, N.K.; Singh, R.K.; Vijayan, P.K.; Saha, D.; Singh, R.K.; Joshi, V.M.

    2011-01-01

    Particle Image Velocimetry (PIV) is a non-intrusive technique for simultaneously measuring the velocities at many points in a fluid flow. The PIV system used is comprised of Nd:YAG laser source, CCD (Charged Coupled Device) camera, timing controller (to control the laser and camera) and software used for analyzing the flow velocities. Several case studies related to nuclear reactor were performed with the PIV system. Some of the cases like flow in circular tube, submerged jet, natural convection in a water pool, flow field of moderator inlet diffuser of 500 MWe Pressurised Heavy Water Reactor (PHWR) and fluidic flow control device (FFCD) used in advanced accumulator of Emergency Core Cooling System (ECCS) have been studied using PIV system. Theoretical studies have been performed and comparisons with PIV results are also given in the present studies. (author)

  15. Painleve Analysis and Darboux Transformation for a Variable-Coefficient Boussinesq System in Fluid Dynamics with Symbolic Computation

    International Nuclear Information System (INIS)

    Li Hongzhe; Tian Bo; Li Lili; Zhang Haiqiang

    2010-01-01

    The new soliton solutions for the variable-coefficient Boussinesq system, whose applications are seen in fluid dynamics, are studied in this paper with symbolic computation. First, the Painleve analysis is used to investigate its integrability properties. For the identified case we give, the Lax pair of the system is found, and then the Darboux transformation is constructed. At last, some new soliton solutions are presented via the Darboux method. Those solutions might be of some value in fluid dynamics. (general)

  16. Geology, mineralogy and ore fluid characteristics of the Masjed Daghi gold bearing veins system, NW Iran

    Directory of Open Access Journals (Sweden)

    Susan Ebrahimi

    2017-11-01

    Full Text Available Introduction The Masjed- Daghi gold deposit lies in an area of widespread Cenozoic volcanic and plutonic rocks at the intersection of the Alborz- Azarbaijan and Urumieh- Dokhtar belts. The area was covered by a detailed exploration program, including geological maps at 1:1,000 scales (~8 km², several hundred meters of trenches and systematic sampling for Au, Ag, Pb, Zn, Cu, As, Hg analysis, and 16 diamond drill holes at a total of 1200 meters (Mohammadi et al, 2005. The vein type gold deposit in Masjed- Daghi is closely associated with a porphyry type Cu-Au deposit. Our study focuses on the gold bearing veins system in an attempt to understand the characteristics of ore fluids and mechanisms of ore formation, and to develop exploration criteria for Masjed Daghi and similar occurrences in Alborz and other Cenozoic magmatic assemblages in Iran. Materials and methods Various rock types, alteration assemblages and mineral parageneses were characterized by transmitting and reflected light microscopy, X-ray diffraction (XRD and electron microprobe analysis. Microprobe analyses were performed using a JEOL 8600 Superprobe electron microprobe at Saskatchewan University. Operating conditions were an accelerating voltage of 15 kV and a beam current of 50 nA. Representative samples from drill holes were selected for fluid inclusion studies. Fluid inclusion data were obtained using a fluid Inc. adapted USGS gas flow heating and freezing system at the Department of Geological Science at the University of Saskatchewan, Canada. To investigate the source of ore fluids, representative sulfidic samples from drill holes were selected for sulfur isotope studies. Isotopic analyses were performed using a Thermo Finnigan DeltaPlus at the G.G. Hatch Stable Isotope Laboratories, University of Ottawa. The standard error of analyses is less than ±0.1 per mil. Results Auriferous quartz veins in Masjed- Daghi are associated with porphyry style mineralization. Various

  17. Study on Mixed Working Fluids with Different Compositions in Organic Rankine Cycle (ORC Systems for Vehicle Diesel Engines

    Directory of Open Access Journals (Sweden)

    Kai Yang

    2014-08-01

    Full Text Available One way to increase the thermal efficiency of vehicle diesel engines is to recover waste heat by using an organic Rankine cycle (ORC system. Tests were conducted to study the running performances of diesel engines in the whole operating range. The law of variation of the exhaust energy rate under various engine operating conditions was also analyzed. A diesel engine-ORC combined system was designed, and relevant evaluation indexes proposed. The variation of the running performances of the combined system under various engine operating conditions was investigated. R245fa and R152a were selected as the components of the mixed working fluid. Thereafter, six kinds of mixed working fluids with different compositions were presented. The effects of mixed working fluids with different compositions on the running performances of the combined system were revealed. Results show that the running performances of the combined system can be improved effectively when mass fraction R152a in the mixed working fluid is high and the engine operates with high power. For the mixed working fluid M1 (R245fa/R152a, 0.1/0.9, by mass fraction, the net power output of the combined system reaches the maximum of 34.61 kW. Output energy density of working fluid (OEDWF, waste heat recovery efficiency (WHRE, and engine thermal efficiency increasing ratio (ETEIR all reach their maximum values at 42.7 kJ/kg, 10.90%, and 11.29%, respectively.

  18. Fluid and rock interactions in silicate and aluminosilicate systems at elevated pressure and temperature

    Science.gov (United States)

    Davis, Mary Kathleen

    Understanding fluid chemistry in the subduction zone environment is key to unraveling the details of element transport from the slab to the surface. Solubilities of cations, such as silicon, in water strongly affect both the physical and chemical properties of supercritical metamorphic fluids. Modeling the thermodynamics of fluid-rock interactions requires therefore a profound understanding of cation dissolution and aqueous speciation. In situ Raman experiments of the silica-water, alumina-water, and alumina water systems were performed in an externally heated Bassett-type diamond-anvil cell at the Department of Geological Sciences, University of Michigan. Natural quartz samples and synthetic ruby samples were used in the experiments. Samples were loaded in the sample chamber with a water pressure medium. All experiments used rhenium gaskets of uniform thickness with a 500 mum drill hole for the sample chamber. Temperature was measured using K-type thermocouples encompassing both the upper and lower diamond anvils. Pressures are obtained on the basis of the Raman shift of the 464 cm-1 quartz mode where possible or the Raman shift of the tips of the diamond anvils according to a method developed in this work. This work characterizes the state of stress in the diamond anvil cell, which is used as the basis for the pressure calibration using only the diamond anvils. Raman measurements of silicate fluid confirm the presence of H4 SiO4 and H6Si2O7 in solution and expand the pressure range for in-situ structural observations in the silica-water system. Additionally, we identify the presence of another silica species present at mantle conditions, which occurs at long time scales in the diamond cell. This study provides the first in situ data in the alumina-water and alumina-silica-water systems at pressures and temperatures relevant to the slab environment. Al(OH) 3 appears to be the dominant form of alumina present under these conditions and in the alumina

  19. Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection

    DEFF Research Database (Denmark)

    Ostergaard, Christian; Benfield, Thomas

    2009-01-01

    ABSTRACT: INTRODUCTION: Macrophage Migration Inhibitory Factor (MIF) plays an essential pathophysiological role in septic shock; however, its role in central nervous system infection (CNS) remains to be defined. METHODS: The aim of the present study was to investigate cerebrospinal fluid (CSF......-22725) vs. 3240ng/L (1563-9302), respectively, P=0.003), and in patients with impaired consciousness (8614 ng/L (3344-20935) vs. 2625 ng/L (1561-7530), respectively, P=0.02). CSF MIF levels correlated significantly to the meningeal inflammation (Psystemic inflammatory response (P>0...

  20. Influence of geometrical imperfections on the buckling loads and vibrations of fluid structure systems

    International Nuclear Information System (INIS)

    Combescure, A.

    1983-05-01

    The buckling of shells subjected to seismic type of loads is not very well known. To study this type of phenomenon, theoretical and experimental investigations on structures consisting of two shells separed by a thin fluid layer , and submitted to a seismic type of load have been performed. The objectives of these investigations are the following: study coupling between buckling modes vibrations modes and buckling, and the effects of this coupling on the level of pressure; study of the appearance on such structures of dynamic instabilities processes; qualification of computer codes of the CEASEMT system; and, qualification or criticism of the methodology used in the design based on a ''static equivalent'' idea

  1. Positron emission tomography - a new technique for observing fluid behaviour in engineering systems

    International Nuclear Information System (INIS)

    Stewart, P.A.E.; Rogers, J.D.; Skelton, R.T.

    1988-01-01

    Positron emission tomography promises to become a powerful new technique for flow tracing and measurement within metal structures in general and operating engines in particular. The principles involved are outlined, and a mobile positron camera system being developed jointly by Rolls-Royce, Castrol, the University of Birmingham and the Rutherford-Appleton Laboratory of the SERC is described. Finally, illustrative examples of the camera's capability are presented drawn from its use to study lubricating fluid flow in the bearings of a Viper gas turbine engine on test up to 100% full power. (author)

  2. Reliability Based Design of Fluid Power Pitch Systems for Wind Turbines

    DEFF Research Database (Denmark)

    Liniger, Jesper; N. Soltani, Mohsen; Pedersen, Henrik Clemmensen

    2017-01-01

    Priority Number. The Failure Mode and Effect Criticality Analysis is based on past research concerning failure analysis of wind turbine drive trains. Guidelines are given to select the severity, occurrence and detection score that make up the risk priority number. The usability of the method is shown...... in a case study of a fluid power pitch system applied to wind turbines. The results show a good agreement to recent field failure data for offshore turbines where the dominating failure modes are related to valves, accumulators and leakage. The results are further used for making design improvements...

  3. Bioluminescence and the Actin Cytoskeleton in the Dinoflagellate Pyrocystis fusiformis: An Examination of Organelle Transport and Mechanotransduction

    OpenAIRE

    McDougall, Carrie A.

    2002-01-01

    Bioluminescence (BL), light produced by organisms, is a diverse and widespread marine phenomenon. yet little studied by researchers. Major contributors to sea surface BL displays are dinoflagellates, which produce rapid BL flashes upon fluid motion; mechanical stimulation triggers a 200-ms flash within 20 ms, representing one of the most rapid sensor-effector transduction systems described. In some dinoflagellate species the sensor-effector link is not constant throughout a 24-hour period. Me...

  4. Fluid dynamics of acoustic and hydrodynamic cavitation in hydraulic power systems

    Science.gov (United States)

    Ferrari, A.

    2017-03-01

    Cavitation is the transition from a liquid to a vapour phase, due to a drop in pressure to the level of the vapour tension of the fluid. Two kinds of cavitation have been reviewed here: acoustic cavitation and hydrodynamic cavitation. As acoustic cavitation in engineering systems is related to the propagation of waves through a region subjected to liquid vaporization, the available expressions of the sound speed are discussed. One of the main effects of hydrodynamic cavitation in the nozzles and orifices of hydraulic power systems is a reduction in flow permeability. Different discharge coefficient formulae are analysed in this paper: the Reynolds number and the cavitation number result to be the key fluid dynamical parameters for liquid and cavitating flows, respectively. The latest advances in the characterization of different cavitation regimes in a nozzle, as the cavitation number reduces, are presented. The physical cause of choked flows is explained, and an analogy between cavitation and supersonic aerodynamic flows is proposed. The main approaches to cavitation modelling in hydraulic power systems are also reviewed: these are divided into homogeneous-mixture and two-phase models. The homogeneous-mixture models are further subdivided into barotropic and baroclinic models. The advantages and disadvantages of an implementation of the complete Rayleigh-Plesset equation are examined.

  5. Research on integrated simulation of fluid-structure system by computation science techniques

    International Nuclear Information System (INIS)

    Yamaguchi, Akira

    1996-01-01

    In Power Reactor and Nuclear Fuel Development Corporation, the research on the integrated simulation of fluid-structure system by computation science techniques has been carried out, and by its achievement, the verification of plant systems which has depended on large scale experiments is substituted by computation science techniques, in this way, it has been aimed at to reduce development costs and to attain the optimization of FBR systems. For the purpose, it is necessary to establish the technology for integrally and accurately analyzing complicated phenomena (simulation technology), the technology for applying it to large scale problems (speed increasing technology), and the technology for assuring the reliability of the results of analysis when simulation technology is utilized for the permission and approval of FBRs (verifying technology). The simulation of fluid-structure interaction, the heat flow simulation in the space with complicated form and the related technologies are explained. As the utilization of computation science techniques, the elucidation of phenomena by numerical experiment and the numerical simulation as the substitute for tests are discussed. (K.I.)

  6. Fluid pipeline system leak detection based on neural network and pattern recognition

    International Nuclear Information System (INIS)

    Tang Xiujia

    1998-01-01

    The mechanism of the stress wave propagation along the pipeline system of NPP, caused by turbulent ejection from pipeline leakage, is researched. A series of characteristic index are described in time domain or frequency domain, and compress numerical algorithm is developed for original data compression. A back propagation neural networks (BPNN) with the input matrix composed by stress wave characteristics in time domain or frequency domain is first proposed to classify various situations of the pipeline, in order to detect the leakage in the fluid flow pipelines. The capability of the new method had been demonstrated by experiments and finally used to design a handy instrument for the pipeline leakage detection. Usually a pipeline system has many inner branches and often in adjusting dynamic condition, it is difficult for traditional pipeline diagnosis facilities to identify the difference between inner pipeline operation and pipeline fault. The author first proposed pipeline wave propagation identification by pattern recognition to diagnose pipeline leak. A series of pattern primitives such as peaks, valleys, horizon lines, capstan peaks, dominant relations, slave relations, etc., are used to extract features of the negative pressure wave form. The context-free grammar of symbolic representation of the negative wave form is used, and a negative wave form parsing system with application to structural pattern recognition based on the representation is first proposed to detect and localize leaks of the fluid pipelines

  7. Development of real-time visualization system for Computational Fluid Dynamics on parallel computers

    International Nuclear Information System (INIS)

    Muramatsu, Kazuhiro; Otani, Takayuki; Matsumoto, Hideki; Takei, Toshifumi; Doi, Shun

    1998-03-01

    A real-time visualization system for computational fluid dynamics in a network connecting between a parallel computing server and the client terminal was developed. Using the system, a user can visualize the results of a CFD (Computational Fluid Dynamics) simulation on the parallel computer as a client terminal during the actual computation on a server. Using GUI (Graphical User Interface) on the client terminal, to user is also able to change parameters of the analysis and visualization during the real-time of the calculation. The system carries out both of CFD simulation and generation of a pixel image data on the parallel computer, and compresses the data. Therefore, the amount of data from the parallel computer to the client is so small in comparison with no compression that the user can enjoy the swift image appearance comfortably. Parallelization of image data generation is based on Owner Computation Rule. GUI on the client is built on Java applet. A real-time visualization is thus possible on the client PC only if Web browser is implemented on it. (author)

  8. Self lubricating fluid bearings

    International Nuclear Information System (INIS)

    Kapich, D.D.

    1980-01-01

    The invention concerns self lubricating fluid bearings, which are used in a shaft sealed system extending two regions. These regions contain fluids, which have to be isolated. A first seal is fluid tight for the first region between the carter shaft and the shaft. The second seal is fluid tight between the carter and the shaft, it communicates with the second region. The first fluid region is the environment surrounding the shaft carter. The second fluid region is a part of a nuclear reactor which contains the cooling fluid. The shaft is conceived to drive a reactor circulating and cooling fluid [fr

  9. Large Matched-Index-of-Refraction (MIR) Flow Systems for International Collaboration In Fluid Mechanics

    International Nuclear Information System (INIS)

    McEligot, Donald M.; Becker, Stefan; McIlroy, Hugh M. Jr.

    2010-01-01

    In recent international collaboration, INL and Uni. Erlangen have developed large MIR flow systems which can be ideal for joint graduate student education and research. The benefit of the MIR technique is that it permits optical measurements to determine flow characteristics in complex passages and around objects to be obtained without locating a disturbing transducer in the flow field and without distortion of the optical paths. The MIR technique is not new itself; others employed it earlier. The innovation of these MIR systems is their large size relative to previous experiments, yielding improved spatial and temporal resolution. This report will discuss the benefits of the technique, characteristics of the systems and some examples of their applications to complex situations. Typically their experiments have provided new fundamental understanding plus benchmark data for assessment and possible validation of computational thermal fluid dynamic codes.

  10. A warning system based on the RFID technology for running-out of injection fluid.

    Science.gov (United States)

    Huang, Chi-Fang; Lin, Jen-Hung

    2011-01-01

    For providing an automatic warning system of running-out of injection fluid, RFID technology is applied in this work to propose an infrastructure with low cost to help nurses and patient's company. Specially, a RFID tag is designed and attached on a bag of intravenous drip to demonstrate the benefits in the present system. The main idea of this system is that, tag is disabled when the bag is not empty because of the EM loading due to the liquid contained. The bag can be any kind in the current market and be without any electronic attachment or modification. LAN (Local Area Network) is also applied as a part of this infrastructure for data transmission.

  11. Large Matched-Index-of-Refraction (MIR) Flow Systems for International Collaboration In Fluid Mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Donald M. McEligot; Stefan Becker; Hugh M. McIlroy, Jr.

    2010-07-01

    In recent international collaboration, INL and Uni. Erlangen have developed large MIR flow systems which can be ideal for joint graduate student education and research. The benefit of the MIR technique is that it permits optical measurements to determine flow characteristics in complex passages and around objects to be obtained without locating a disturbing transducer in the flow field and without distortion of the optical paths. The MIR technique is not new itself; others employed it earlier. The innovation of these MIR systems is their large size relative to previous experiments, yielding improved spatial and temporal resolution. This report will discuss the benefits of the technique, characteristics of the systems and some examples of their applications to complex situations. Typically their experiments have provided new fundamental understanding plus benchmark data for assessment and possible validation of computational thermal fluid dynamic codes.

  12. Design and optimisation of dual-mode heat pump systems using natural fluids

    International Nuclear Information System (INIS)

    Zhang Wenling; Klemeš, Jiří Jaromír; Kim, Jin-Kuk

    2012-01-01

    The paper introduces new multi-period modelling and design methodology for dual-mode heat pumps using natural fluids. First, a mathematical model is developed to capture thermodynamic and operating characteristics of dual-mode heat pump systems, subject to different ambient temperatures. The multi-period optimisation framework has been developed to reflect different ambient conditions and its influences on heat pump performance, as well as to determine a system capacity of heat pump which allows systematic economic trade-offs between supplementary heating (or cooling) and operating cost for heat pump. Case study considering three geographical locations with different heating and cooling demands is presented to illustrate the importance of using multi-period optimisation for the design of heat pump systems.

  13. Survey of a numerical procedure for the solution of hyperbolic systems of three dimensional fluid flow

    International Nuclear Information System (INIS)

    Graf, U.

    1986-01-01

    A combination of several numerical methods is used to construct a procedure for effective calculation of complex three-dimensional fluid flow problems. The split coefficient matrix (SCM) method is used so that the differenced equations of the hyperbolic system do not disturb correct signal propagation. The semi-discretisation of the equations of the SCM method is done with the asymmetric, separated region, weighted residual (ASWR) method to give accurate solutions on a relatively coarse mesh. For the resulting system of ordinary differential equations, a general-purpose ordinary differential equation solver is used in conjunction with a method of fractional steps for an economic solution of the large system of linear equations. (orig.) [de

  14. Space Station fluid management logistics

    Science.gov (United States)

    Dominick, Sam M.

    1990-01-01

    Viewgraphs and discussion on space station fluid management logistics are presented. Topics covered include: fluid management logistics - issues for Space Station Freedom evolution; current fluid logistics approach; evolution of Space Station Freedom fluid resupply; launch vehicle evolution; ELV logistics system approach; logistics carrier configuration; expendable fluid/propellant carrier description; fluid carrier design concept; logistics carrier orbital operations; carrier operations at space station; summary/status of orbital fluid transfer techniques; Soviet progress tanker system; and Soviet propellant resupply system observations.

  15. C-O-H-S magmatic fluid system in shrinkage bubbles of melt inclusions

    Science.gov (United States)

    Robidoux, P.; Frezzotti, M. L.; Hauri, E. H.; Aiuppa, A.

    2016-12-01

    Magmatic volatiles include multiple phases in the C-O-H-S system of shrinkage bubbles for which a conceptual model is still unclear during melt inclusion formation [1,2,3,4]. The present study aims to qualitatively explore the evolution of the volatile migration, during and after the formation of the shrinkage bubble in melt inclusions trapped by olivines from Holocene to present at San Cristóbal volcano (Nicaragua), Central American Volcanic Arc (CAVA). Combined scanning electron microscope (SEM) and Raman spectroscopy observations allow to define the mineral-fluid phases inside typical shrinkage bubbles at ambient temperature. The existence of residual liquid water is demonstrated in the shrinkage bubbles of naturally quenched melt inclusion and this water could represents the principal agent for chemical reactions with other dissolved ionic species (SO42-, CO32-, etc.) and major elements (Mg, Fe, Cu, etc.) [4,5]. With the objective of following the cooling story of the bubble-inclusion system, the new methodological approach here estimate the interval of equilibrium temperatures for each SEM-Raman identified mineral phase (carbonates, hydrous carbonates, sulfurs, sulfates, etc.). Finally, two distinct mechanisms are proposed to describe the evolution of this heterogeneous fluid system in bubble samples at San Cristóbal which imply a close re-examination for similar volcanoes in subduction zone settings: (1) bubbles are already contracted and filled by volatiles by diffusion processes from the glass and leading to a C-O-H-S fluid-glass reaction enriched in Mg-Fe-Cu elements (2) bubbles are formed by oversaturation of the volatiles from the magma which is producing an immiscible metal-rich fluid. [1]Moore et al. (2015). Am. Mineral. 100, 806-823 [2]Wallace et al. (2015). Am. Mineral. 100, 787-794 [3]Lowenstern (2015). Am. Mineral. 100, 672-673 [4]Esposito, et al. (2016). Am. Mineral. 101, 1691-1708 [5]Kamenetsky et al. (2001). Earth Planet. Sci. Lett. 184, 685-702

  16. Studies on variable swirl intake system for DI diesel engine using computational fluid dynamics

    Directory of Open Access Journals (Sweden)

    Jebamani Rathnaraj David

    2008-01-01

    Full Text Available It is known that a helical port is more effective than a tangential port to attain the required swirl ratio with minimum sacrifice in the volumetric efficiency. The swirl port is designed for lesser swirl ratio to reduce emissions at higher speeds. But this condition increases the air fuel mixing time and particulate smoke emissions at lower speeds. Optimum swirl ratio is necessary according to the engine operating condition for optimum combustion and emission reduction. Hence the engine needs variable swirl to enhance the combustion in the cylinder according to its operating conditions, for example at partial load or low speed condition it requires stronger swirl, while the air quantity is more important than the swirl under very high speed or full load and maximum torque conditions. The swirl and charging quantity can easily trade off and can be controlled by the opening of the valve. Hence in this study the steady flow rig experiment is used to evaluate the swirl of a helical intake port design for different operating conditions. The variable swirl plate set up of the W06DTIE2 engine is used to experimentally study the swirl variation for different openings of the valve. The sliding of the swirl plate results in the variation of the area of inlet port entry. Therefore in this study a swirl optimized combustion system varying according to the operating conditions by a variable swirl plate mechanism is studied experimentally and compared with the computational fluid dynamics predictions. In this study the fluent computational fluid dynamics code has been used to evaluate the flow in the port-cylinder system of a DI diesel engine in a steady flow rig. The computational grid is generated directly from 3-D CAD data and in cylinder flow simulations, with inflow boundary conditions from experimental measurements, are made using the fluent computational fluid dynamics code. The results are in very good agreement with experimental results.

  17. Delayed methotrexate excretion in infants and young children with primary central nervous system tumors and postoperative fluid collections.

    Science.gov (United States)

    Wright, Karen D; Panetta, John C; Onar-Thomas, Arzu; Reddick, Wilburn E; Patay, Zoltan; Qaddoumi, Ibrahim; Broniscer, Alberto; Robinson, Giles; Boop, Frederick A; Klimo, Paul; Ward, Deborah; Gajjar, Amar; Stewart, Clinton F

    2015-01-01

    High-dose methotrexate (HD-MTX) has been used to treat children with central nervous system tumors. Accumulation of MTX within pleural, peritoneal, or cardiac effusions has led to delayed excretion and increased risk of systemic toxicity. This retrospective study analyzed the association of intracranial post-resection fluid collections with MTX plasma disposition in infants and young children with brain tumors. Brain MRI findings were analyzed for postoperative intracranial fluid collections in 75 pediatric patients treated with HD-MTX and for whom serial MTX plasma concentrations (MTX) were collected. Delayed plasma excretion was defined as (MTX) ≥1 μM at 42 hours (h). Leucovorin was administered at 42 h and then every 6 h until (MTX) collections present. Population average (inter-individual variation) MTX clearance was 96.0 ml/min/m² (41.1 CV %) and increased with age. Of the patients with intracranial fluid collections, 24 had delayed excretion; only 2 of the 17 without fluid collections (P collection, total leucovorin dosing, or hydration fluids between those with and without toxicity. Although an intracranial fluid collection is associated with delayed MTX excretion, HD-MTX can be safely administered with monitoring of infants and young children with intracranial fluid collections. Infants younger than 1 year may need additional monitoring to avoid toxicity.

  18. Thermal protection system gap analysis using a loosely coupled fluid-structural thermal numerical method

    Science.gov (United States)

    Huang, Jie; Li, Piao; Yao, Weixing

    2018-05-01

    A loosely coupled fluid-structural thermal numerical method is introduced for the thermal protection system (TPS) gap thermal control analysis in this paper. The aerodynamic heating and structural thermal are analyzed by computational fluid dynamics (CFD) and numerical heat transfer (NHT) methods respectively. An interpolation algorithm based on the control surface is adopted for the data exchanges on the coupled surface. In order to verify the analysis precision of the loosely coupled method, a circular tube example was analyzed, and the wall temperature agrees well with the test result. TPS gap thermal control performance was studied by the loosely coupled method successfully. The gap heat flux is mainly distributed in the small region at the top of the gap which is the high temperature region. Besides, TPS gap temperature and the power of the active cooling system (CCS) calculated by the traditional uncoupled method are higher than that calculated by the coupled method obviously. The reason is that the uncoupled method doesn't consider the coupled effect between the aerodynamic heating and structural thermal, however the coupled method considers it, so TPS gap thermal control performance can be analyzed more accurately by the coupled method.

  19. Calculation of fluid (steam) hammer loading to piping systems by the response spectrum method

    International Nuclear Information System (INIS)

    Krause, G.; Schrader, W.; Leimbach, K.R.

    1983-01-01

    Today computations of fluid and steam hammer loading to piping systems are usually performed as a time-history analysis in which the transient pressure forces act as external excitations. For practical purposes it is desirable to be able to treat fluid hammer loading using the response spectrum method similarily as loads from external events. Two advantages arise from the use of spectra in the analysis of piping systems subjected to dynamic force excitations. Firstly, the response spectrum method is much less sensitive to model idealization than the time-history method. Secondly, computational efforts are reduced. In this paper the algorithm for the treatment of force excitations through the modal response spectrum method is briefly presented. The effect of the residuum accounting for higher modes which are not part of the modal decomposition is considered. In particular various methods of superposition of the responses of the dynamic forces and of the modes are investigated. Results and comparisons are presented of several response spectrum analyses and time-history analyses. (orig.)

  20. Cerebrospinal fluid dynamics in a simplified model of the human ventricular system

    International Nuclear Information System (INIS)

    Ammourah, S.; Aroussi, A.; Vloeberghs, M.

    2003-01-01

    This study investigates the flow of the Cerebrospinal Fluid (CSF) inside a simplified model of the human ventricular system. Both computational and experimental results are explored. Due to the complexity of the real geometry, a simplified three-dimensional (3-D) model of the ventricular system was constructed with the same volume as the real geometry. The numerical study was conducted using the commercial computational fluid dynamics (CFD) package FLUENT-6. Different CFD cases were solved for different flow rates range between 100-500 ml/day. A scaled up to 4:1 physical model with the same geometry as the computational model, was built. A diluted dye was injected into the physical model and visualized. From the CFD studies it was found that the flow pattern of the CSF is structured and has a 3-D motion. Recirculating motion takes place in the lateral ventricles in the form of small eddies at each plane. Experimentally, the dye reverse motion noticed confirms the CFD findings about the presence of a recirculating motion. (author)

  1. Reduced abrasion drilling fluid

    NARCIS (Netherlands)

    2010-01-01

    A reduced abrasion drilling fluid system and method of drilling a borehole by circulating the reduced abrasion drilling fluid through the borehole is disclosed. The reduced abrasion drilling fluid comprises a drilling fluid, a first additive and a weighting agent, wherein the weighting agent has a

  2. Reduced abrasion drilling fluid

    NARCIS (Netherlands)

    2012-01-01

    A reduced abrasion drilling fluid system and method of drilling a borehole by circulating the reduced abrasion drilling fluid through the borehole is disclosed. The reduced abrasion drilling fluid comprises a drilling fluid, a first additive and a weighting agent, wherein the weighting agent has a

  3. PUMP DESIGN AND COMPUTATIONAL FLUID DYNAMIC ANALYSIS FOR HIGH TEMPERATURE SULFURIC ACID TRANSFER SYSTEM

    Directory of Open Access Journals (Sweden)

    JUNG-SIK CHOI

    2014-06-01

    Full Text Available In this study, we proposed a newly designed sulfuric acid transfer system for the sulfur-iodine (SI thermochemical cycle. The proposed sulfuric acid transfer system was evaluated using a computational fluid dynamics (CFD analysis for investigating thermodynamic/hydrodynamic characteristics and material properties. This analysis was conducted to obtain reliable continuous operation parameters; in particular, a thermal analysis was performed on the bellows box and bellows at amplitudes and various frequencies (0.1, 0.5, and 1.0 Hz. However, the high temperatures and strongly corrosive operating conditions of the current sulfuric acid system present challenges with respect to the structural materials of the transfer system. To resolve this issue, we designed a novel transfer system using polytetrafluoroethylene (PTFE, Teflon® as a bellows material for the transfer of sulfuric acid. We also carried out a CFD analysis of the design. The CFD results indicated that the maximum applicable temperature of PTFE is about 533 K (260 °C, even though its melting point is around 600 K. This result implies that the PTFE is a potential material for the sulfuric acid transfer system. The CFD simulations also confirmed that the sulfuric acid transfer system was designed properly for this particular investigation.

  4. Steel slag carbonation in a flow-through reactor system: the role of fluid-flux.

    Science.gov (United States)

    Berryman, Eleanor J; Williams-Jones, Anthony E; Migdisov, Artashes A

    2015-01-01

    Steel production is currently the largest industrial source of atmospheric CO2. As annual steel production continues to grow, the need for effective methods of reducing its carbon footprint increases correspondingly. The carbonation of the calcium-bearing phases in steel slag generated during basic oxygen furnace (BOF) steel production, in particular its major constituent, larnite {Ca2SiO4}, which is a structural analogue of olivine {(MgFe)2SiO4}, the main mineral subjected to natural carbonation in peridotites, offers the potential to offset some of these emissions. However, the controls on the nature and efficiency of steel slag carbonation are yet to be completely understood. Experiments were conducted exposing steel slag grains to a CO2-H2O mixture in both batch and flow-through reactors to investigate the impact of temperature, fluid flux, and reaction gradient on the dissolution and carbonation of steel slag. The results of these experiments show that dissolution and carbonation of BOF steel slag are more efficient in a flow-through reactor than in the batch reactors used in most previous studies. Moreover, they show that fluid flux needs to be optimized in addition to grain size, pressure, and temperature, in order to maximize the efficiency of carbonation. Based on these results, a two-stage reactor consisting of a high and a low fluid-flux chamber is proposed for CO2 sequestration by steel slag carbonation, allowing dissolution of the slag and precipitation of calcium carbonate to occur within a single flow-through system. Copyright © 2014. Published by Elsevier B.V.

  5. Linear image reconstruction for a diffuse optical mammography system in a noncompressed geometry using scattering fluid

    International Nuclear Information System (INIS)

    Nielsen, Tim; Brendel, Bernhard; Ziegler, Ronny; Beek, Michiel van; Uhlemann, Falk; Bontus, Claas; Koehler, Thomas

    2009-01-01

    Diffuse optical tomography (DOT) is a potential new imaging modality to detect or monitor breast lesions. Recently, Philips developed a new DOT system capable of transmission and fluorescence imaging, where the investigated breast is hanging freely into the measurement cup containing scattering fluid. We present a fast and robust image reconstruction algorithm that is used for the transmission measurements. The algorithm is based on the Rytov approximation. We show that this algorithm can be used over a wide range of tissue optical properties if the reconstruction is adapted to each patient. We use estimates of the breast shape and average tissue optical properties to initialize the reconstruction, which improves the image quality significantly. We demonstrate the capability of the measurement system and reconstruction to image breast lesions by clinical examples

  6. Interactive finite difference preprocessor for three-dimensional fluid flow systems. [PREFLO

    Energy Technology Data Exchange (ETDEWEB)

    Kleinstreuer, C. (Rensselaer Polytechnic Inst., Troy, NY); Patterson, M.R.

    1981-06-01

    A preprocessor, called PREFLO, consisting of data processing modules combined with a flexible finite difference grid generator is described. This economical, interactive computer code is a useful research tool contributing significantly to the accurate analysis and modeling of large and/or geometrically complex flow systems. PREFLO (PREprocessor for fluid FLOw problems), written in FORTRAN IV, consists of four modules which in turn call various subroutines. The main programs accomplish the following tasks: (1) system identification and selection of appropriate finite difference algorithms; (2) input devices for storage of natural flow boundaries; (3) interactive generation of finite difference meshes and display of computer graphics; (4) preparation of all data files for the source program. The computation of the velocity field near a power plant site is outlined to illustrate the capabilities and application of PREFLO.

  7. Systems and Methods for Determining Water-Cut of a Fluid Mixture

    KAUST Repository

    Karimi, Muhammad Akram

    2017-03-02

    Provided in some embodiments are systems and methods for measuring the water content (or water-cut) of a fluid mixture. Provided in some embodiments is a water-cut sensor system that includes a T-resonator, a ground conductor, and a separator. The T-resonator including a feed line, and an open shunt stub conductively coupled to the feed line. The ground conductor including a bottom ground plane opposite the T-resonator and a ground ring conductively coupled to the bottom ground plane, with the feed line overlapping at least a portion of the ground ring. The separator including a dielectric material disposed between the feed line and the portion of the ground ring overlapped by the feed line, and the separator being adapted to electrically isolate the T-resonator from the ground conductor.

  8. Systems and Methods for Determining Water-Cut of a Fluid Mixture

    KAUST Repository

    Karimi, Muhammad Akram

    2017-12-07

    Provided in some embodiments are systems and methods for measuring the water content (or water-cut) of a fluid mixture. Provided in some embodiments is a water-cut sensor system that includes a helical T-resonator, a helical ground conductor, and a separator provided at an exterior of a cylindrical pipe. The helical T-resonator including a feed line, and a helical open shunt stub conductively coupled to the feed line. The helical ground conductor including a helical ground plane opposite the helical open shunt stub and a ground ring conductively coupled to the helical ground plane. The feed line overlapping at least a portion of the ground ring, and the separator disposed between the feed line and the portion of the ground ring overlapped by the feed line to electrically isolate the helical T-resonator from the helical ground conductor.

  9. Cerebrospinal fluid analysis in the HIV infection and compartmentalization of HIV in the central nervous system

    Directory of Open Access Journals (Sweden)

    Sérgio Monteiro de Almeida

    2015-07-01

    Full Text Available The nervous system plays an important role in HIV infection. The purpose of this review is to discuss the indications for cerebrospinal fluid (CSF analysis in HIV infection in clinical practice. CSF analysis in HIV infection is indicated for the diagnosis of opportunistic infections and co-infections, diagnosis of meningitis caused by HIV, quantification of HIV viral load, and analysis of CNS HIV compartmentalization. Although several CSF biomarkers have been investigated, none are clinically applicable. The capacity of HIV to generate genetic diversity, in association with the constitutional characteristics of the CNS, facilitates the generation of HIV quasispecies in the CNS that are distinct from HIV in the systemic circulation. CSF analysis has a well-defined and valuable role in the diagnosis of CNS infections in HIV/AIDS patients. Further research is necessary to establish a clinically applicable biomarker for the diagnosis of HIV-associated neurocognitive disorders.

  10. Temperature and velocity measurement fields of fluids using a schlieren system.

    Science.gov (United States)

    Martínez-González, Adrian; Guerrero-Viramontes, J A; Moreno-Hernández, David

    2012-06-01

    This paper proposes a combined method for two-dimensional temperature and velocity measurements in liquid and gas flow using a schlieren system. Temperature measurements are made by relating the intensity level of each pixel in a schlieren image to the corresponding knife-edge position measured at the exit focal plane of the schlieren system. The same schlieren images were also used to measure the velocity of the fluid flow. The measurement is made by using particle image velocimetry (PIV). The PIV software used in this work analyzes motion between consecutive schlieren frames to obtain velocity fields. The proposed technique was applied to measure the temperature and velocity fields in the natural convection of water provoked by a heated rectangular plate.

  11. Fluid sample collection and distribution system. [qualitative analysis of aqueous samples from several points

    Science.gov (United States)

    Brooks, R. L. (Inventor)

    1979-01-01

    A multipoint fluid sample collection and distribution system is provided wherein the sample inputs are made through one or more of a number of sampling valves to a progressive cavity pump which is not susceptible to damage by large unfiltered particles. The pump output is through a filter unit that can provide a filtered multipoint sample. An unfiltered multipoint sample is also provided. An effluent sample can be taken and applied to a second progressive cavity pump for pumping to a filter unit that can provide one or more filtered effluent samples. The second pump can also provide an unfiltered effluent sample. Means are provided to periodically back flush each filter unit without shutting off the whole system.

  12. Use of Generalized Fluid System Simulation Program (GFSSP) for Teaching and Performing Senior Design Projects at the Educational Institutions

    Science.gov (United States)

    Majumdar, A. K.; Hedayat, A.

    2015-01-01

    This paper describes the experience of the authors in using the Generalized Fluid System Simulation Program (GFSSP) in teaching Design of Thermal Systems class at University of Alabama in Huntsville. GFSSP is a finite volume based thermo-fluid system network analysis code, developed at NASA/Marshall Space Flight Center, and is extensively used in NASA, Department of Defense, and aerospace industries for propulsion system design, analysis, and performance evaluation. The educational version of GFSSP is freely available to all US higher education institutions. The main purpose of the paper is to illustrate the utilization of this user-friendly code for the thermal systems design and fluid engineering courses and to encourage the instructors to utilize the code for the class assignments as well as senior design projects.

  13. Hydrodynamic cavitation to improve bulk fluid to surface mass transfer in a nonimmersed ultraviolet system for minimal processing of opaque and transparent fluid foods.

    Science.gov (United States)

    Milly, P J; Toledo, R T; Chen, J; Kazem, B

    2007-11-01

    Ultraviolet (UV)-induced chemical reactions and inactivation of microorganisms in transparent and opaque fluids are strongly dependent upon the homogenous exposure of the target species to the UV irradiation. Current UV technologies used in water disinfection and food preservation applications have limited efficacy due to suspended particles shading target species. An Ultraviolet-Shockwave Power Reactor (UV-SPR) consisting of an inner rotating rotor and a stationary quartz housing and 2 end plates was used to induce 'controlled cavitation.' Eight UV low-pressure mercury lamps spaced uniformly were installed lengthwise around the quartz housing periphery. A KI to I(3) (-)chemical dosimeter for UV was used to quantify photons received by fluid in the annular space of the SPR. UV dose (J/m(2)) increased from 97 J/m(2) at 0 rpm to over 700 J/m(2) for SPR speeds above 2400 rpm. Inactivation of E. coli 25922 in apple juice and skim milk in the UV-SPR at exit temperatures below 45 degrees C was greater than 4.5 and 3 logs, respectively. The UV-SPR system proved successful in increasing the mass transfer of transparent and opaque fluid to the UV irradiated surface.

  14. Temporal changes in fluid chemistry and energy profiles in the vulcano island hydrothermal system.

    Science.gov (United States)

    Rogers, Karyn L; Amend, Jan P; Gurrieri, Sergio

    2007-12-01

    In June 2003, the geochemical composition of geothermal fluids was determined at 9 sites in the Vulcano hydrothermal system, including sediment seeps, geothermal wells, and submarine vents. Compositional data were combined with standard state reaction properties to determine the overall Gibbs free energy (DeltaG(r) ) for 120 potential lithotrophic and heterotrophic reactions. Lithotrophic reactions in the H-O-N-S-C-Fe system were considered, and exergonic reactions yielded up to 120 kJ per mole of electrons transferred. The potential for heterotrophy was characterized by energy yields from the complete oxidation of 6 carboxylic acids- formic, acetic, propanoic, lactic, pyruvic, and succinic-with the following redox pairs: O(2)/H(2)O, SO(4) (2)/H(2)S, NO(3) ()/NH(4) (+), S(0)/H(2)S, and Fe(3)O(4)/Fe(2+). Heterotrophic reactions yielded 6-111 kJ/mol e(). Energy yields from both lithotrophic and heterotrophic reactions were highly dependent on the terminal electron acceptor (TEA); reactions with O(2) yielded the most energy, followed by those with NO(3) (), Fe(III), SO(4) (2), and S(0). When only reactions with complete TEA reduction were included, the exergonic lithotrophic reactions followed a similar electron tower. Spatial variability in DeltaG(r) was significant for iron redox reactions, owing largely to the wide range in Fe(2+) and H(+) concentrations. Energy yields were compared to those obtained for samples collected in June 2001. The temporal variations in geochemical composition and energy yields observed in the Vulcano hydrothermal system between 2001 and 2003 were moderate. The largest differences in DeltaG(r) over the 2 years were from iron redox reactions, due to temporal changes in the Fe(2+) and H(+) concentrations. The observed variations in fluid composition across the Vulcano hydrothermal system have the potential to influence not only microbial diversity but also the metabolic strategies of the resident microbial communities.

  15. A Fluid Membrane-Based Soluble Ligand Display System for Live CellAssays

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Jwa-Min; Nair, Pradeep N.; Neve, Richard M.; Gray, Joe W.; Groves, Jay T.

    2005-10-14

    Cell communication modulates numerous biological processes including proliferation, apoptosis, motility, invasion and differentiation. Correspondingly, there has been significant interest in the development of surface display strategies for the presentation of signaling molecules to living cells. This effort has primarily focused on naturally surface-bound ligands, such as extracellular matrix components and cell membranes. Soluble ligands (e.g. growth factors and cytokines) play an important role in intercellular communications, and their display in a surface-bound format would be of great utility in the design of array-based live cell assays. Recently, several cell microarray systems that display cDNA, RNAi, or small molecules in a surface array format were proven to be useful in accelerating high-throughput functional genetic studies and screening therapeutic agents. These surface display methods provide a flexible platform for the systematic, combinatorial investigation of genes and small molecules affecting cellular processes and phenotypes of interest. In an analogous sense, it would be an important advance if one could display soluble signaling ligands in a surface assay format that allows for systematic, patterned presentation of soluble ligands to live cells. Such a technique would make it possible to examine cellular phenotypes of interest in a parallel format with soluble signaling ligands as one of the display parameters. Herein we report a ligand-modified fluid supported lipid bilayer (SLB) assay system that can be used to functionally display soluble ligands to cells in situ (Figure 1A). By displaying soluble ligands on a SLB surface, both solution behavior (the ability to become locally enriched by reaction-diffusion processes) and solid behavior (the ability to control the spatial location of the ligands in an open system) could be combined. The method reported herein benefits from the naturally fluid state of the supported membrane, which allows

  16. The spring balance: a simple monitoring system for fluid overload during hysteroscopic surgery

    NARCIS (Netherlands)

    Ankum, W. M.; Vonk, J.

    1994-01-01

    Fluid overload may arise during hysteroscopic surgery, caused by absorption of fluid used to distend the uterus. Continuous monitoring of the fluid balance is required to prevent this serious complication. Commercial equipment does not serve this purpose adequately. We describe a simple solution. We

  17. Heparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagen.

    Directory of Open Access Journals (Sweden)

    Zhong-Dong Shi

    2011-01-01

    Full Text Available Interstitial flow directly affects cells that reside in tissues and regulates tissue physiology and pathology by modulating important cellular processes including proliferation, differentiation, and migration. However, the structures that cells utilize to sense interstitial flow in a 3-dimensional (3D environment have not yet been elucidated. Previously, we have shown that interstitial flow upregulates matrix metalloproteinase (MMP expression in rat vascular smooth muscle cells (SMCs and fibroblasts/myofibroblasts via activation of an ERK1/2-c-Jun pathway, which in turn promotes cell migration in collagen. Herein, we focused on uncovering the flow-induced mechanotransduction mechanism in 3D.Cleavage of rat vascular SMC surface glycocalyx heparan sulfate (HS chains from proteoglycan (PG core proteins by heparinase or disruption of HS biosynthesis by silencing N-deacetylase/N-sulfotransferase 1 (NDST1 suppressed interstitial flow-induced ERK1/2 activation, interstitial collagenase (MMP-13 expression, and SMC motility in 3D collagen. Inhibition or knockdown of focal adhesion kinase (FAK also attenuated or blocked flow-induced ERK1/2 activation, MMP-13 expression, and cell motility. Interstitial flow induced FAK phosphorylation at Tyr925, and this activation was blocked when heparan sulfate proteoglycans (HSPGs were disrupted. These data suggest that HSPGs mediate interstitial flow-induced mechanotransduction through FAK-ERK. In addition, we show that integrins are crucial for mechanotransduction through HSPGs as they mediate cell spreading and maintain cytoskeletal rigidity.We propose a conceptual mechanotransduction model wherein cell surface glycocalyx HSPGs, in the presence of integrin-mediated cell-matrix adhesions and cytoskeleton organization, sense interstitial flow and activate the FAK-ERK signaling axis, leading to upregulation of MMP expression and cell motility in 3D. This is the first study to describe a flow-induced mechanotransduction

  18. The influence of buffer system and biological fluids on the degradation of magnesium.

    Science.gov (United States)

    Törne, Karin; Örnberg, Andreas; Weissenrieder, Jonas

    2017-08-01

    The influence of frequently used buffer system 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) compared to CO 2 /HCO3- on the corrosion of magnesium is investigated. Samples were immersed in simulated body fluid (m-SBF) while monitored by electrochemical impedance spectroscopy (EIS) for up to 30 days. In CO 2 /HCO3- the initial corrosion rate was 0.11 mm yr -1 . An inner protective layer of magnesium oxide was formed within the first 30 min exposure and subsequently covered by an outer layer of apatite within 24 h . The corrosion mechanism thereafter is best described as passive pitting with a porosity of ∼10%. Using HEPES as buffer agent increased the corrosion rate to 3.37 mm yr -1 . Cross sectional microscopy show a porous outer corrosion layer allowing rapid diffusion of aggressive ions through the film. Here the EIS results are best described by an active pitting model with an inner layer 5 to 10 times less protective compared to the inner layer formed without HEPES. Further the suitability of human whole blood and plasma as in vitro models for Mg degradation was evaluated. Mg corrosion caused coagulation after 24 h in both biological fluids. The corrosion during the first 24 h is similar to the corrosion in m-SBF with HEPES. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1490-1502, 2017. © 2016 Wiley Periodicals, Inc.

  19. A Note on an Analytic Solution for an Incompressible Fluid-Conveying Pipeline System

    Directory of Open Access Journals (Sweden)

    Vincent O. S. Olunloyo

    2017-01-01

    Full Text Available This paper presents an integral transform analytic solution to the equations governing a fluid-conveying pipeline segment where a gyroscopic or Coriolis force effect is taken into consideration. The mathematical model idealizes a segment of the pipeline as an elastic beam conveying an incompressible fluid. It is clearly shown that when such a system is supported at both ends and in a free motion, the Coriolis force dissipates no energy (or simply does not work as it generates conjugate complex vibratory components for all flow velocities. It is demonstrated that the modal natural frequencies can be computed from the algebraic products of the complex frequency pairs. Clearly, the patterns of the characteristics of the system’s natural frequencies are seen partly when the real and imaginary components are plotted, as widely seen in the literature. Nonetheless, results from this study revealed that a continuity profile exists to connect the subcritical, critical, and postcritical vibratory behaviours when the absolute values are plotted for any velocity. In the meantime, the efficacy and versatility of this method against the usual assumed spatial or temporal modal solutions are demonstrated by confirming the predictions and validity of results of earlier workers such as Paidoussis, Ziegler, and others where pre- and postdivergence behaviours are exhibited.

  20. Substrate and mechanotransduction influence SERCA2a localization in human pluripotent stem cell-derived cardiomyocytes affecting functional performance

    Directory of Open Access Journals (Sweden)

    Sebastian Martewicz

    2017-12-01

    In this work, we show involvement of the mechanotransduction pathway RhoA/ROCK in the structural reorganization of hPSC-derived cardiomyocytes after adhesion plating. These structural changes have a major impact on the intracellular localization of SERCA2 pumps and concurrent improvement in calcium cycling. The process is triggered by cell interaction with the culture substrate, which mechanical cues drive sarcomeric alignment and SERCA2a spreading and relocalization from a perinuclear to a whole-cell distribution. This structural reorganization is mediated by the mechanical properties of the substrate, as shown by the process failure in hPSC-CMs cultured on soft 4 kPa hydrogels as opposed to physiologically stiff 16 kPa hydrogels and glass. Finally, pharmacological inhibition of Rho-associated protein kinase (ROCK by different compounds identifies this specific signaling pathway as a major player in SERCA2 localization and the associated improvement in hPSC-CMs calcium handling ability in vitro.

  1. Changes in muscle cell metabolism and mechanotransduction are associated with myopathic phenotype in a mouse model of collagen VI deficiency.

    Directory of Open Access Journals (Sweden)

    Sara De Palma

    Full Text Available This study identifies metabolic and protein phenotypic alterations in gastrocnemius, tibialis anterior and diaphragm muscles of Col6a1(-/- mice, a model of human collagen VI myopathies. All three muscles of Col6a1(-/- mice show some common changes in proteins involved in metabolism, resulting in decreased glycolysis and in changes of the TCA cycle fluxes. These changes lead to a different fate of α-ketoglutarate, with production of anabolic substrates in gastrocnemius and tibialis anterior, and with lipotoxicity in diaphragm. The metabolic changes are associated with changes of proteins involved in mechanotransduction at the myotendineous junction/costameric/sarcomeric level (TN-C, FAK, ROCK1, troponin I fast and in energy metabolism (aldolase, enolase 3, triose phosphate isomerase, creatine kinase, adenylate kinase 1, parvalbumin, IDH1 and FASN. Together, these change may explain Ca(2+ deregulation, impaired force development, increased muscle-relaxation-time and fiber damage found in the mouse model as well as in patients. The severity of these changes differs in the three muscles (gastrocnemius

  2. Fluid dynamics simulations of a fuel processing system; Stroemungsmechanische Modellierung eines Brenngaserzeugungssystems

    Energy Technology Data Exchange (ETDEWEB)

    Scharf, Florian

    2012-07-01

    The present thesis deals with the topic of the complete fluid dynamic modelling of the key components of a fuel processing system and based on it the development of the next generation reactors. Fuel cell auxilliary power units enable an energy efficient power generation for mobile applications with higher on-board power consumption. Enabling the operation of the fuel cell with the available middle-destillate on-board, the fuel is transformed to an hydrogen-rich gas in a fuel processing system consisting of the key components autothermal reformer, water-shift reactor and catalytic burner. The modules of the fuel processing system are thereby integrated within the reactors to obtain a lightweighted and compact overall system. The complete numerical description of theses systems are based on chemical-reaction models, vaporization models of fuel and water in the integrated reactant treatment and as well on models for the integrated heat-exchanger. The strong interaction between the single reactor zones require therefore modelling of the key components as an overall reactor system. The methodology of the present thesis is based on a tight integration of CFD simulations with experimental analysis and the construction of the reactors. The results of carried out prototype testings, post-mortem-analysis and laboratory experiments are taken as basis for the CFD modelling and the reactor construction. As numerical tool for fluid dynamic modelling the CFD software FLUENT was used. In the context of this thesis the CFD modelling library was extended with the purpose of the complete description of key components in the CFD overall model. In these CFD overall models the thermal interactions between the reactor zones as well as the influence of the pulsating fuel injection and the chemical reactions are taken into account. For this purpose a similarity theoretical CFD modell of the pulsating fuel injection was generated based on results from prototype testings and high

  3. Entropy production in a fluid-solid system far from thermodynamic equilibrium.

    Science.gov (United States)

    Chung, Bong Jae; Ortega, Blas; Vaidya, Ashwin

    2017-11-24

    The terminal orientation of a rigid body in a moving fluid is an example of a dissipative system, out of thermodynamic equilibrium and therefore a perfect testing ground for the validity of the maximum entropy production principle (MaxEP). Thus far, dynamical equations alone have been employed in studying the equilibrium states in fluid-solid interactions, but these are far too complex and become analytically intractable when inertial effects come into play. At that stage, our only recourse is to rely on numerical techniques which can be computationally expensive. In our past work, we have shown that the MaxEP is a reliable tool to help predict orientational equilibrium states of highly symmetric bodies such as cylinders, spheroids and toroidal bodies. The MaxEP correctly helps choose the stable equilibrium in these cases when the system is slightly out of thermodynamic equilibrium. In the current paper, we expand our analysis to examine i) bodies with fewer symmetries than previously reported, for instance, a half-ellipse and ii) when the system is far from thermodynamic equilibrium. Using two-dimensional numerical studies at Reynolds numbers ranging between 0 and 14, we examine the validity of the MaxEP. Our analysis of flow past a half-ellipse shows that overall the MaxEP is a good predictor of the equilibrium states but, in the special case of the half-ellipse with aspect ratio much greater than unity, the MaxEP is replaced by the Min-MaxEP, at higher Reynolds numbers when inertial effects come into play. Experiments in sedimentation tanks and with hinged bodies in a flow tank confirm these calculations.

  4. Circulation of fluids in the gastrovascular system of a stoloniferan octocoral.

    Science.gov (United States)

    Parrin, Austin P; Netherton, Sarah E; Bross, Lori S; McFadden, Catherine S; Blackstone, Neil W

    2010-10-01

    Cilia-based transport systems characterize sponges and placozoans. Cilia are employed in cnidarian gastrovascular systems as well, but typically function in concert with muscular contractions. Previous reports suggest that anthozoans may be an exception to this pattern, utilizing only cilia in their gastrovascular systems. With an inverted microscope and digital image analysis, we used stoloniferan octocoral colonies growing on microscope cover glass to quantitatively describe the movement of fluids in this system for the first time. Flow in stolons (diameter ≈300 μm) is simultaneously bidirectional, with average velocities of 100-200 μm/s in each direction. Velocities are maximal immediately adjacent to the stolon wall and decrease to a minimum in the center of the stolon. Flow velocity is unaffected by stolonal contractions, suggesting that muscular peristalsis is not a factor in propelling the flow. Stolon intersections (diameter ≈500 μm) occur below polyps and serve as traffic roundabouts with unidirectional, circular flow. Such cilia-driven transport may be the plesiomorphic state for the gastrovascular system of cnidarians.

  5. A semi-active control suspension system for railway vehicles with magnetorheological fluid dampers

    Science.gov (United States)

    Wei, Xiukun; Zhu, Ming; Jia, Limin

    2016-07-01

    The high-speed train has achieved great progress in the last decades. It is one of the most important modes of transportation between cities. With the rapid development of the high-speed train, its safety issue is paid much more attention than ever before. To improve the stability of the vehicle with high speed, extra dampers (i.e. anti-hunting damper) are used in the traditional bogies with passive suspension system. However, the curving performance of the vehicle is undermined due to the extra lateral force generated by the dampers. The active suspension systems proposed in the last decades attempt to solve the vehicle steering issue. However, the active suspension systems need extra actuators driven by electrical power or hydraulic power. There are some implementation and even safety issues which are not easy to be overcome. In this paper, an innovative semi-active controlled lateral suspension system for railway vehicles is proposed. Four magnetorheological fluid dampers are fixed to the primary suspension system of each bogie. They are controlled by online controllers for enhancing the running stability on the straight track line on the one hand and further improving the curving performance by controlling the damper force on the other hand. Two control strategies are proposed in the light of the pure rolling concept. The effectiveness of the proposed strategies is demonstrated by SIMPACK and Matlab co-simulation for a full railway vehicle with two conventional bogies.

  6. Effect of working fluids on the performance of a novel direct vapor generation solar organic Rankine cycle system

    International Nuclear Information System (INIS)

    Li, Jing; Alvi, Jahan Zeb; Pei, Gang; Ji, Jie; Li, Pengcheng; Fu, Huide

    2016-01-01

    Highlights: • A novel, flexible direct vapor generation solar ORC is proposed. • Technical feasibility of the system is discussed. • Fluid effect on collector efficiency is explored. • The system is more efficient than solar ORC with HTF. - Abstract: A novel solar organic Rankine cycle (ORC) system with direct vapor generation (DVG) is proposed. A heat storage unit is embedded in the ORC to guarantee the stability of power generation. Compared with conventional solar ORCs, the proposed system avoids the secondary heat transfer intermediate and shows good reaction to the fluctuation of solar radiation. The technical feasibility of the system is discussed. Performance is analyzed by using 17 dry and isentropic working fluids. Fluid effects on the efficiencies of ORC, collectors and the whole system are studied. The results indicate that the collector efficiency generally decreases while the ORC and system efficiencies increase with the increment in fluid critical temperature. At evaporation temperature of 120 °C and solar radiation of 800 Wm −2 , the ORC, collector and overall thermal efficiencies of R236fa are 10.59, 56.14 and 5.08% while their values for Benzene are 12.5, 52.58 and 6.57% respectively. The difference between collector efficiencies using R236fa and Benzene gets larger at lower solar radiation. The heat collection is strongly correlated with latent and sensible heat of the working fluid. Among the fluids, R123 exhibits the highest overall performance and seems to be suitable for the proposed system in the short term.

  7. Effects of non-uniform temperature gradients on surface tension driven two component magneto convection in a porous- fluid system

    Science.gov (United States)

    Manjunatha, N.; Sumithra, R.

    2018-04-01

    The problem of surface tension driven two component magnetoconvection is investigated in a Porous-Fluid system, consisting of anincompressible two component electrically conducting fluid saturatedporous layer above which lies a layer of the same fluid in the presence of a uniform vertical magnetic field. The lower boundary of the porous layeris rigid and the upper boundary of the fluid layer is free with surfacetension effects depending on both temperature and concentration, boththese boundaries are insulating to heat and mass. At the interface thevelocity, shear and normal stress, heat and heat flux, mass and mass fluxare assumed to be continuous suitable for Darcy-Brinkman model. Theeigenvalue problem is solved in linear, parabolic and inverted parabolictemperature profiles and the corresponding Thermal Marangoni Numberis obtained for different important physical parameters.

  8. Generalized Fluid System Simulation Program, Version 5.0-Educational. Supplemental Information for NASA/TM-2011-216470. Supplement

    Science.gov (United States)

    Majumdar, A. K.

    2011-01-01

    The Generalized Fluid System Simulation Program (GFSSP) is a finite-volume based general-purpose computer program for analyzing steady state and time-dependent flow rates, pressures, temperatures, and concentrations in a complex flow network. The program is capable of modeling real fluids with phase changes, compressibility, mixture thermodynamics, conjugate heat transfer between solid and fluid, fluid transients, pumps, compressors and external body forces such as gravity and centrifugal. The thermofluid system to be analyzed is discretized into nodes, branches, and conductors. The scalar properties such as pressure, temperature, and concentrations are calculated at nodes. Mass flow rates and heat transfer rates are computed in branches and conductors. The graphical user interface allows users to build their models using the point, drag and click method; the users can also run their models and post-process the results in the same environment. The integrated fluid library supplies thermodynamic and thermo-physical properties of 36 fluids and 21 different resistance/source options are provided for modeling momentum sources or sinks in the branches. This Technical Memorandum illustrates the application and verification of the code through 12 demonstrated example problems. This supplement gives the input and output data files for the examples.

  9. Fundamental study on turbulent fluid mixing characteristics in piping systems. Fundamental study on fluid mixing mechanism in T-junction areas

    International Nuclear Information System (INIS)

    Toda, Saburo; Yuki, Kazuhisa; Muramatsu, Toshiharu

    2002-03-01

    In a region where two fluids with different temperatures are mixed together, unsteady temperature fluctuation, i.e. thermal striping, occurs in going through the unstable mixing process of the fluids, and structural materials in the surrounding area may be damaged by high-cycle thermal fatigue. In this report, in order to clarify the relation between the thermal striping and temperature fluctuation of structural wall, PIV measuring system is applied to visualize the fluid mixing state in a T-junction area in which important parameters for the fluid mixing are the flow velocity and aperture ratios of a main pipe to a small pipe and an incidence angle of the small pipe to the main pipe as well as temperature difference of the two flows. As a result of visualization experiments in a isothermal field, it is confirmed that a jet-axis, which is a stream line flowing out from the center of the small pipe, vibrates unsteadily and that its behavior is strongly affected by circulating flow, Karman vortex formed behind the jet axis, and especially flow-fluctuation which exists as a background-flow in the main pipe. Especially, the frequency band of the flow-fluctuation in the main pipe almost corresponds to that of the vibration of the jet-axis where the ratio of flow rate is low. Furthermore, in order to estimate the vibration state of the jet-axis and to find out the conditions for preventing the thermal fatigue, the penetration depth of the jet-axis is generalized. From measurements of temperature fluctuation of wall, it is shown that a high power fluctuation area exists universally behind the junction point of the small pipe where the flow rate of the small pipe flow is relatively lower than that of the main pipe flow. The band of dominant frequency of the temperature fluctuation is almost the same as the flow-fluctuation and the jet-axis vibration mentioned above. In addition, visualization experiments of secondary flow formed in a 90-degree bend, which is installed

  10. Carbon dioxide as working fluid for medium and high-temperature concentrated solar thermal systems

    Directory of Open Access Journals (Sweden)

    Van Duong

    2014-03-01

    Full Text Available This paper explores the benefits and drawbacks of using carbon dioxide in solar thermal systems at medium and high operating temperatures. For medium temperatures, application of CO2 in non-imaging-optics based compound parabolic concentrators (CPC combined with evacuated-tube collectors is studied. These collectors have been shown to obtain efficiencies higher than 40% operating at around 200℃ without the need of tracking. Validated numerical models of external compound parabolic concentrators (XCPCs are used to simulate their performance using CO2 as working fluid. For higher temperatures, a mathematical model is implemented to analyze the operating performance of a parabolic trough solar collector (PTC using CO2 at temperatures between 100℃ and 600℃.

  11. Neutron kinetics of fluid-fuel systems by the quasi-static method

    International Nuclear Information System (INIS)

    Dulla, S.; Ravetto, P.; Rostagno, M.M.

    2004-01-01

    The quasi-static method for the neutron kinetics of nuclear reactors is generalized for application to neutron multiplying systems fueled by a fluid multiplying material, typically a mixture of fissile molten salts. The method is derived by the application of factorization formulae for both the neutron density and the delayed precursor concentrations and the projection of the balance equations upon a weighting function. A physically meaningful weight can be assumed as the solution of the adjoint model, which is constructed for the situation considered, including delayed neutrons. The quasi-static scheme is then applied to calculations of some transients for a typical configuration of a molten-salt reactor, in a multigroup diffusion model with a one-dimensional slug-flow velocity field. The physical features associated to the motion of the fissile material are highlighted

  12. Computer Software for Design, Analysis and Control of Fluid Power Systems

    DEFF Research Database (Denmark)

    Conrad, Finn; Sørensen, Torben; Grahl-Madsen, Mads

    1999-01-01

    This Deliverable presents contributions from SWING's Task 2.3 Analysis of available software solutions. The Deliverable has focus on the results from this analysis having in mind the task objectives·to carry out a thorough analysis of the state-of the-art solutions for fluid power systems modelling...... and simulation,·results should be suitable to draw conclusions in Task 2.4 Synthesis of analysis results and recommendations, · consideration of integrating results from EU-funded research projects (here: contributions to ISO 10303 Standard STEP),·the impact on recommendation of smart use of simulation...... and modelling IT tools in the implementation planning (WP3) and pilot implementation (WP4), in particular training programme for key people in the individual SME and/or cluster....

  13. Internal Thermal Control System Hose Heat Transfer Fluid Thermal Expansion Evaluation Test Report

    Science.gov (United States)

    Wieland, P. O.; Hawk, H. D.

    2001-01-01

    During assembly of the International Space Station, the Internal Thermal Control Systems in adjacent modules are connected by jumper hoses referred to as integrated hose assemblies (IHAs). A test of an IHA has been performed at the Marshall Space Flight Center to determine whether the pressure in an IHA filled with heat transfer fluid would exceed the maximum design pressure when subjected to elevated temperatures (up to 60 C (140 F)) that may be experienced during storage or transportation. The results of the test show that the pressure in the IHA remains below 227 kPa (33 psia) (well below the 689 kPa (100 psia) maximum design pressure) even at a temperature of 71 C (160 F), with no indication of leakage or damage to the hose. Therefore, based on the results of this test, the IHA can safely be filled with coolant prior to launch. The test and results are documented in this Technical Memorandum.

  14. Benchmark Simulation of Natural Circulation Cooling System with Salt Working Fluid Using SAM

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, K. K.; Scarlat, R. O.; Hu, R.

    2017-09-03

    Liquid salt-cooled reactors, such as the Fluoride Salt-Cooled High-Temperature Reactor (FHR), offer passive decay heat removal through natural circulation using Direct Reactor Auxiliary Cooling System (DRACS) loops. The behavior of such systems should be well-understood through performance analysis. The advanced system thermal-hydraulics tool System Analysis Module (SAM) from Argonne National Laboratory has been selected for this purpose. The work presented here is part of a larger study in which SAM modeling capabilities are being enhanced for the system analyses of FHR or Molten Salt Reactors (MSR). Liquid salt thermophysical properties have been implemented in SAM, as well as properties of Dowtherm A, which is used as a simulant fluid for scaled experiments, for future code validation studies. Additional physics modules to represent phenomena specific to salt-cooled reactors, such as freezing of coolant, are being implemented in SAM. This study presents a useful first benchmark for the applicability of SAM to liquid salt-cooled reactors: it provides steady-state and transient comparisons for a salt reactor system. A RELAP5-3D model of the Mark-1 Pebble-Bed FHR (Mk1 PB-FHR), and in particular its DRACS loop for emergency heat removal, provides steady state and transient results for flow rates and temperatures in the system that are used here for code-to-code comparison with SAM. The transient studied is a loss of forced circulation with SCRAM event. To the knowledge of the authors, this is the first application of SAM to FHR or any other molten salt reactors. While building these models in SAM, any gaps in the code’s capability to simulate such systems are identified and addressed immediately, or listed as future improvements to the code.

  15. Improving the economy-of-scale of small organic rankine cycle systems through appropriate working fluid selection

    International Nuclear Information System (INIS)

    White, Martin; Sayma, Abdulnaser I.

    2016-01-01

    Highlights: • Novel system model coupling turbine and ORC system performance. • Contour plots to characterise working fluid and turbine performance. • Changing working fluid can expand pump and turbine operating envelope. • Possible to improve the economy-of-scale through optimal working fluid selection. - Abstract: Organic Rankine cycles (ORC) are becoming a major research area within the field of sustainable energy systems. However, a major challenge facing the widespread implementation of small and mini-scale ORC systems is the economy-of-scale. To overcome this challenge requires single components that can be manufactured in large volumes and then implemented into a wide variety of different applications where the heat source conditions may vary. The aim of this paper is to investigate whether working fluid selection can improve the current economy-of-scale by enabling the same system components to be used in multiple ORC systems. This is done through coupling analysis and optimisation of the energy process, with a performance map for a small-scale ORC radial turbine. The performance map, obtained using CFD, is adapted to account for additional loss mechanisms not accounted for in the original CFD simulation before being non-dimensionalised using a modified similitude theory developed for subsonic ORC turbines. The updated performance map is then implemented into a thermodynamic model, enabling the construction of a single performance contour that displays the range of heat source conditions that can be accommodated by the existing turbine whilst using a particular working fluid. Constructing this performance map for a range of working fluids, this paper demonstrates that through selecting a suitable working fluid, the same turbine can efficiently utilise heat sources between 360 and 400 K, with mass flow rates ranging between 0.5 and 2.75 kg/s respectively. This corresponds to using the same turbine in ORC applications where the heat available ranges

  16. Facial fluid synthesis for assessment of acne vulgaris using luminescent visualization system through optical imaging and integration of fluorescent imaging system

    Science.gov (United States)

    Balbin, Jessie R.; Dela Cruz, Jennifer C.; Camba, Clarisse O.; Gozo, Angelo D.; Jimenez, Sheena Mariz B.; Tribiana, Aivje C.

    2017-06-01

    Acne vulgaris, commonly called as acne, is a skin problem that occurs when oil and dead skin cells clog up in a person's pores. This is because hormones change which makes the skin oilier. The problem is people really do not know the real assessment of sensitivity of their skin in terms of fluid development on their faces that tends to develop acne vulgaris, thus having more complications. This research aims to assess Acne Vulgaris using luminescent visualization system through optical imaging and integration of image processing algorithms. Specifically, this research aims to design a prototype for facial fluid analysis using luminescent visualization system through optical imaging and integration of fluorescent imaging system, and to classify different facial fluids present in each person. Throughout the process, some structures and layers of the face will be excluded, leaving only a mapped facial structure with acne regions. Facial fluid regions are distinguished from the acne region as they are characterized differently.

  17. Identification and activity of acetate-assimilating bacteria in diffuse fluids venting from two deep-sea hydrothermal systems.

    Science.gov (United States)

    Winkel, Matthias; Pjevac, Petra; Kleiner, Manuel; Littmann, Sten; Meyerdierks, Anke; Amann, Rudolf; Mußmann, Marc

    2014-12-01

    Diffuse hydrothermal fluids often contain organic compounds such as hydrocarbons, lipids, and organic acids. Microorganisms consuming these compounds at hydrothermal sites are so far only known from cultivation-dependent studies. To identify potential heterotrophs without prior cultivation, we combined microbial community analysis with short-term incubations using (13)C-labeled acetate at two distinct hydrothermal systems. We followed cell growth and assimilation of (13)C into single cells by nanoSIMS combined with fluorescence in situ hybridization (FISH). In 55 °C-fluids from the Menez Gwen hydrothermal system/Mid-Atlantic Ridge, a novel epsilonproteobacterial group accounted for nearly all assimilation of acetate, representing the first aerobic acetate-consuming member of the Nautiliales. In contrast, Gammaproteobacteria dominated the (13) C-acetate assimilation in incubations of 37 °C-fluids from the back-arc hydrothermal system in the Manus Basin/Papua New Guinea. Here, 16S rRNA gene sequences were mostly related to mesophilic Marinobacter, reflecting the high content of seawater in these fluids. The rapid growth of microorganisms upon acetate addition suggests that acetate consumers in diffuse fluids are copiotrophic opportunists, which quickly exploit their energy sources, whenever available under the spatially and temporally highly fluctuating conditions. Our data provide first insights into the heterotrophic microbial community, catalyzing an under-investigated part of microbial carbon cycling at hydrothermal vents. © 2014 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

  18. Calculation of interfacial tensions with gradient theory. I. Pure and Pseudo-Pure Fluids. II. Binary Systems

    DEFF Research Database (Denmark)

    Zuo, You-Xiang; Stenby, Erling Halfdan

    1997-01-01

    .26% at low pressure, and that of naphtha reformate cuts was 3.6%. In addition, the gradient theory was used to predict interfacial tensions for binary systems in the near-critical region. The results show excellent agreement between the predicted and experimental IFTs at high and moderate levels, while....... A consistent procedure for the estimation of properties associated to lumped systems. Fluid Phase Equilibria, 87: 89-197] was used to lump a mixture into one pseudocomponent, and its IFTs were calculated by means of the method of pure fluids. On the basis of the SRK EOS, the overall AAD of mixtures was 3...

  19. Evaluation of CO2-Fluid-Rock Interaction in Enhanced Geothermal Systems: Field-Scale Geochemical Simulations

    Directory of Open Access Journals (Sweden)

    Feng Pan

    2017-01-01

    Full Text Available Recent studies suggest that using supercritical CO2 (scCO2 instead of water as a heat transmission fluid in Enhanced Geothermal Systems (EGS may improve energy extraction. While CO2-fluid-rock interactions at “typical” temperatures and pressures of subsurface reservoirs are fairly well known, such understanding for the elevated conditions of EGS is relatively unresolved. Geochemical impacts of CO2 as a working fluid (“CO2-EGS” compared to those for water as a working fluid (H2O-EGS are needed. The primary objectives of this study are (1 constraining geochemical processes associated with CO2-fluid-rock interactions under the high pressures and temperatures of a typical CO2-EGS site and (2 comparing geochemical impacts of CO2-EGS to geochemical impacts of H2O-EGS. The St. John’s Dome CO2-EGS research site in Arizona was adopted as a case study. A 3D model of the site was developed. Net heat extraction and mass flow production rates for CO2-EGS were larger compared to H2O-EGS, suggesting that using scCO2 as a working fluid may enhance EGS heat extraction. More aqueous CO2 accumulates within upper- and lower-lying layers than in the injection/production layers, reducing pH values and leading to increased dissolution and precipitation of minerals in those upper and lower layers. Dissolution of oligoclase for water as a working fluid shows smaller magnitude in rates and different distributions in profile than those for scCO2 as a working fluid. It indicates that geochemical processes of scCO2-rock interaction have significant effects on mineral dissolution and precipitation in magnitudes and distributions.

  20. Thermodynamics investigation of a solar power system integrated oil and molten salt as heat transfer fluids

    International Nuclear Information System (INIS)

    Liu, Qibin; Bai, Zhang; Sun, Jie; Yan, Yuejun; Gao, Zhichao; Jin, Hongguang

    2016-01-01

    Highlights: • A new concentrating solar power system with a dual-solar field is proposed. • The superheated steam with more than 773 K is produced. • The performances of the proposed system are demonstrated. • The economic feasibility of the proposed system is validated. - Abstract: In this paper, a new parabolic trough solar power system that incorporates a dual-solar field with oil and molten salt as heat transfer fluids (HTFs) is proposed to effectively utilize the solar energy. The oil is chosen as a HTF in the low temperature solar field to heat the feeding water, and the high temperature solar field uses molten salt to superheat the steam that the temperature is higher than 773 K. The produced superheated steam enters a steam turbine to generate power. Energy analysis and exergy analysis of the system are implemented to evaluate the feasibility of the proposed system. Under considerations of variations of solar irradiation, the on-design and off-design thermodynamic performances of the system and the characteristics are investigated. The annual average solar-to-electric efficiency and the nominal efficiency under the given condition for the proposed solar thermal power generation system reach to 15.86% and 22.80%, which are higher than the reference system with a single HTF. The exergy losses within the solar heat transfer process of the proposed system are reduced by 7.8% and 45.23% compared with the solar power thermal systems using oil and molten salt as HTFs, respectively. The integrated approach with oil and molten salt as HTFs can make full use of the different physical properties of the HTFs, and optimize the heat transfer process between the HTFs and the water/steam. The exergy loss in the water evaporation and superheated process are reduced, the system efficiency and the economic performance are improved. The research findings provide a new approach for the improvement of the performances of solar thermal power plants.

  1. Organic Rankine-cycle power systems working fluids study. Topical report No. 1: Fluorinol 85

    Science.gov (United States)

    Jain, M. L.; Demirgian, J. C.; Cole, R. L.

    1986-09-01

    The thermal stability limits and degradation rates of Fluorinol 85 as a function of maximum cycle temperatures are determined. Following the design and construction of a dynamic test loop capable of simulating the thermodynamic conditions of possible prototypical organic Rankine-cycle (ORC) power systems, several test runs were completed. The Fluorinol 85 test loop was operated for about 3800 h at a temperature range of 525 to 600 F. Both liquid and noncondensable vapor (gas) samples were drawn periodically and analyzed using capillary column gas chromatography, gas chromatography/mass spectrometry and mass spectrometry. Results indicate that Fluorinol 85 would not decompose significantly over an extended period, up to a maximum cycle temperature of 550 F. However, 506-h data at 575 F show initiation of significant degradation. The 770-h data at 600 F, using a fresh charge of Fluorinol 85, indicate an annual degradation rate of more than 17.2%. The most significant degradation product observed is hydrofluoric acid, which could cause severe corrosion in an ORC system. Removal of the hydrofluoric acid and prevention of temperature extremes are necessary for an ORC system using Fluorinol 85 as a working fluid.

  2. Computer Simulations and Theoretical Studies of Complex Systems: from complex fluids to frustrated magnets

    Science.gov (United States)

    Choi, Eunsong

    Computer simulations are an integral part of research in modern condensed matter physics; they serve as a direct bridge between theory and experiment by systemactically applying a microscopic model to a collection of particles that effectively imitate a macroscopic system. In this thesis, we study two very differnt condensed systems, namely complex fluids and frustrated magnets, primarily by simulating classical dynamics of each system. In the first part of the thesis, we focus on ionic liquids (ILs) and polymers--the two complementary classes of materials that can be combined to provide various unique properties. The properties of polymers/ILs systems, such as conductivity, viscosity, and miscibility, can be fine tuned by choosing an appropriate combination of cations, anions, and polymers. However, designing a system that meets a specific need requires a concrete understanding of physics and chemistry that dictates a complex interplay between polymers and ionic liquids. In this regard, molecular dynamics (MD) simulation is an efficient tool that provides a molecular level picture of such complex systems. We study the behavior of Poly (ethylene oxide) (PEO) and the imidazolium based ionic liquids, using MD simulations and statistical mechanics. We also discuss our efforts to develop reliable and efficient classical force-fields for PEO and the ionic liquids. The second part is devoted to studies on geometrically frustrated magnets. In particular, a microscopic model, which gives rise to an incommensurate spiral magnetic ordering observed in a pyrochlore antiferromagnet is investigated. The validation of the model is made via a comparison of the spin-wave spectra with the neutron scattering data. Since the standard Holstein-Primakoff method is difficult to employ in such a complex ground state structure with a large unit cell, we carry out classical spin dynamics simulations to compute spin-wave spectra directly from the Fourier transform of spin trajectories. We

  3. Development and Use of Engineering Standards for Computational Fluid Dynamics for Complex Aerospace Systems

    Science.gov (United States)

    Lee, Hyung B.; Ghia, Urmila; Bayyuk, Sami; Oberkampf, William L.; Roy, Christopher J.; Benek, John A.; Rumsey, Christopher L.; Powers, Joseph M.; Bush, Robert H.; Mani, Mortaza

    2016-01-01

    Computational fluid dynamics (CFD) and other advanced modeling and simulation (M&S) methods are increasingly relied on for predictive performance, reliability and safety of engineering systems. Analysts, designers, decision makers, and project managers, who must depend on simulation, need practical techniques and methods for assessing simulation credibility. The AIAA Guide for Verification and Validation of Computational Fluid Dynamics Simulations (AIAA G-077-1998 (2002)), originally published in 1998, was the first engineering standards document available to the engineering community for verification and validation (V&V) of simulations. Much progress has been made in these areas since 1998. The AIAA Committee on Standards for CFD is currently updating this Guide to incorporate in it the important developments that have taken place in V&V concepts, methods, and practices, particularly with regard to the broader context of predictive capability and uncertainty quantification (UQ) methods and approaches. This paper will provide an overview of the changes and extensions currently underway to update the AIAA Guide. Specifically, a framework for predictive capability will be described for incorporating a wide range of error and uncertainty sources identified during the modeling, verification, and validation processes, with the goal of estimating the total prediction uncertainty of the simulation. The Guide's goal is to provide a foundation for understanding and addressing major issues and concepts in predictive CFD. However, this Guide will not recommend specific approaches in these areas as the field is rapidly evolving. It is hoped that the guidelines provided in this paper, and explained in more detail in the Guide, will aid in the research, development, and use of CFD in engineering decision-making.

  4. Distinguishing infected from noninfected abdominal fluid collections after surgery: an imaging, clinical, and laboratory-based scoring system.

    Science.gov (United States)

    Gnannt, Ralph; Fischer, Michael A; Baechler, Thomas; Clavien, Pierre-Alain; Karlo, Christoph; Seifert, Burkhardt; Lesurtel, Mickael; Alkadhi, Hatem

    2015-01-01

    Mortality from abdominal abscesses ranges from 30% in treated cases up to 80% to 100% in patients with undrained or nonoperated abscesses. Various computed tomographic (CT) imaging features have been suggested to indicate infection of postoperative abdominal fluid collections; however, features are nonspecific and substantial overlap between infected and noninfected collections exists. The purpose of this study was to develop and validate a scoring system on the basis of CT imaging findings as well as laboratory and clinical parameters for distinguishing infected from noninfected abdominal fluid collections after surgery. The score developmental cohort included 100 consecutive patients (69 men, 31 women; mean age, 58 ± 17 years) who underwent portal-venous phase CT within 24 hours before CT-guided intervention of postoperative abdominal fluid collections. Imaging features included attenuation (Hounsfield unit [HU]), volume, wall enhancement and thickness, fat stranding, as well as entrapped gas of fluid collections. Laboratory and clinical parameters included diabetes, intake of immunosuppressive drugs, body temperature, C-reactive protein, and leukocyte blood cell count. The score was validated in a separate cohort of 30 consecutive patients (17 men, 13 women; mean age, 51 ± 15 years) with postoperative abdominal fluid collections. Microbiologic analysis from fluid samples served as the standard of reference. Diabetes, body temperature, C-reactive protein, attenuation of the fluid collection (in HUs), wall enhancement and thickness of the wall, adjacent fat stranding, as well as entrapped gas within the fluid collection were significantly different between infected and noninfected collections (P collection (in HUs), as well as entrapped gas as significant independent predictors of infection (P collection, ≥ 20 HU: 4 points; entrapped gas: 3 points). The model was well calibrated (Hosmer-Lemeshow test, P = 0.36). In the validation cohort, scores of 2 or lower

  5. Cerebrospinal fluid HIV infection and pleocytosis: Relation to systemic infection and antiretroviral treatment

    Directory of Open Access Journals (Sweden)

    Petropoulos Christos J

    2005-11-01

    Full Text Available Abstract Background Central nervous system (CNS exposure to HIV is a universal facet of systemic infection. Because of its proximity to and shared barriers with the brain, cerebrospinal fluid (CSF provides a useful window into and model of human CNS HIV infection. Methods Prospective study of the relationships of CSF to plasma HIV RNA, and the effects of: 1 progression of systemic infection, 2 CSF white blood cell (WBC count, 3 antiretroviral therapy (ART, and 4 neurological performance. One hundred HIV-infected subjects were cross-sectionally studied, and 28 were followed longitudinally after initiating or changing ART. Results In cross-sectional analysis, HIV RNA levels were lower in CSF than plasma (median difference 1.30 log10 copies/mL. CSF HIV viral loads (VLs correlated strongly with plasma VLs and CSF WBC counts. Higher CSF WBC counts associated with smaller differences between plasma and CSF HIV VL. CSF VL did not correlate with blood CD4 count, but CD4 counts In subjects starting ART, those with lower CD4 counts had slower initial viral decay in CSF than in plasma. In all subjects, including five with persistent plasma viremia and four with new-onset ADC, CSF HIV eventually approached or reached the limit of viral detection and CSF pleocytosis resolved. Conclusion CSF HIV infection is common across the spectrum of infection and is directly related to CSF pleocytosis, though whether the latter is a response to or a contributing cause of CSF infection remains uncertain. Slowing in the rate of CSF response to ART compared to plasma as CD4 counts decline indicates a changing character of CSF infection with systemic immunological progression. Longer-term responses indicate that CSF infection generally responds well to ART, even in the face of systemic virological failure due to drug resistance. We present simple models to explain the differing relationships of CSF to plasma HIV in these settings.

  6. Feasibility Study of a Simulation Driven Approach for Estimating Reliability of Wind Turbine Fluid Power Pitch Systems

    DEFF Research Database (Denmark)

    Liniger, Jesper; Pedersen, Henrik Clemmensen; N. Soltani, Mohsen

    2018-01-01

    Recent field data indicates that pitch systems account for a substantial part of a wind turbines down time. Reducing downtime means increasing the total amount of energy produced during its lifetime. Both electrical and fluid power pitch systems are employed with a roughly 50/50 distribution. Fluid...... power pitch systems generally show higher reliability and have been favored on larger offshore wind turbines. Still general issues such as leakage, contamination and electrical faults make current systems work sub-optimal. Current field data for wind turbines present overall pitch system reliability...... and the reliability of component groups (valves, accumulators, pumps etc.). However, the failure modes of the components and more importantly the root causes are not evident. The root causes and failure mode probabilities are central for changing current pitch system designs and operational concepts to increase...

  7. Study of three-phase fluid dynamics in a surging production system

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Rodolfo; Assuncao, Pablo Morelato; Ressel, Fabio de Assis [Universidade Federal do Espirito Santo, Sao Mateus, ES (Brazil)

    2010-07-01

    Among others factors, petroleum extraction is subordinate to the reservoir pressure and the required pressure to rise it to the surface production facilities. Reservoir deliverability equations tied production rate with reservoir driving force (Economides, 1994). The Inflow Performance Relationship (IPR) is obtained by measuring the production rates under various drawdown pressures, and is used to assess well performance by plotting the well production rate against the flowing bottonhole pressure. Others limiting rate of production factors are imposed by wellhead required pressure and the production tubing performance. The tubing performance is sensitive to several parameters among which we can highlight the production tubing geometry and the properties of the produced fluids (Guo, 2007). Therewith we can define the Tubing Performance Relationship (TPR) similarly to the IPR. Thus the present work aims the hydraulic performance analysis of a production system with a flowing well without artificial elevation methods. Furthermore the triphasic (water-oil-gas) flow studies, both in the production string and the production line, allowed the inspection of the main variables of the system, fluid properties, operation conditions and geometric parameters, on the head loss. In order obtain all these, several methods were developed, each one with specifics limitations to include all flow patterns. The most common biphasic horizontal flow patterns according to Brill and Beggs (1975) are: mist flow, bubble flow, plug flow, slug flow, stratified flow, wavy flow and annular flow. Yet according to Brill and Beggs (1975) the most common biphasic vertical flow patterns are: bubbly flow, slug flow, churn flow, and annular flow. Accordingly to these, another outbreak discussed is the pattern flow sensibility on the head loss. The methodology used in the present work is based on the discretization of the system in several discrete counterparts cells, in which was where it was applied

  8. Biofluid mechanics of special organs and the issue of system control. Sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008 Pasadena, California.

    Science.gov (United States)

    Zamir, Mair; Moore, James E; Fujioka, Hideki; Gaver, Donald P

    2010-03-01

    In the field of fluid flow within the human body, focus has been placed on the transportation of blood in the systemic circulation since the discovery of that system; but, other fluids and fluid flow phenomena pervade the body. Some of the most fascinating fluid flow phenomena within the human body involve fluids other than blood and a service other than transport--the lymphatic and pulmonary systems are two striking examples. While transport is still involved in both cases, this is not the only service which they provide and blood is not the only fluid involved. In both systems, filtration, extraction, enrichment, and in general some "treatment" of the fluid itself is the primary function. The study of the systemic circulation has also been conventionally limited to treating the system as if it were an open-loop system governed by the laws of fluid mechanics alone, independent of physiological controls and regulations. This implies that system failures can be explained fully in terms of the laws of fluid mechanics, which of course is not the case. In this paper we examine the clinical implications of these issues and of the special biofluid mechanics issues involved in the lymphatic and pulmonary systems.

  9. Assessment of cerebrospinal fluid system dynamics : novel infusion protocol, mathematical modelling and parameter estimation for hydrocephalus investigations

    OpenAIRE

    Andersson, Kennet

    2011-01-01

    Patients with idiopathic normal pressure hydrocephalus (INPH) have a disturbance in the cerebrospinal fluid (CSF) system. The treatment is neurosurgical – a shunt is placed in the CSF system. The infusion test is used to assess CSF system dynamics and to aid in the selection of patients that will benefit from shunt surgery. The infusion test can be divided into three parts: a mathematical model, an infusion protocol and a parameter estimation method. A non-linear differential equation is used...

  10. On a Five-Dimensional Chaotic System Arising from Double-Diffusive Convection in a Fluid Layer

    Directory of Open Access Journals (Sweden)

    R. Idris

    2013-01-01

    Full Text Available A chaotic system arising from double-diffusive convection in a fluid layer is investigated in this paper based on the theory of dynamical systems. A five-dimensional model of chaotic system is obtained using the Galerkin truncated approximation. The results showed that the transition from steady convection to chaos via a Hopf bifurcation produced a limit cycle which may be associated with a homoclinic explosion at a slightly subcritical value of the Rayleigh number.

  11. Use of Generalized Fluid System Simulation Program (GFSSP) for Teaching and Performing Senior Design Projects at the Educational Institutions

    Science.gov (United States)

    Majumdar, A. K.; Hedayat, A.

    2015-01-01

    This paper describes the experience of the authors in using the Generalized Fluid System Simulation Program (GFSSP) in teaching Design of Thermal Systems class at University of Alabama in Huntsville. GFSSP is a finite volume based thermo-fluid system network analysis code, developed at NASA/Marshall Space Flight Center, and is extensively used in NASA, Department of Defense, and aerospace industries for propulsion system design, analysis, and performance evaluation. The educational version of GFSSP is freely available to all US higher education institutions. The main purpose of the paper is to illustrate the utilization of this user-friendly code for the thermal systems design and fluid engineering courses and to encourage the instructors to utilize the code for the class assignments as well as senior design projects. The need for a generalized computer program for thermofluid analysis in a flow network has been felt for a long time in aerospace industries. Designers of thermofluid systems often need to know pressures, temperatures, flow rates, concentrations, and heat transfer rates at different parts of a flow circuit for steady state or transient conditions. Such applications occur in propulsion systems for tank pressurization, internal flow analysis of rocket engine turbopumps, chilldown of cryogenic tanks and transfer lines, and many other applications of gas-liquid systems involving fluid transients and conjugate heat and mass transfer. Computer resource requirements to perform time-dependent, three-dimensional Navier-Stokes computational fluid dynamic (CFD) analysis of such systems are prohibitive and therefore are not practical. Available commercial codes are generally suitable for steady state, single-phase incompressible flow. Because of the proprietary nature of such codes, it is not possible to extend their capability to satisfy the above-mentioned needs. Therefore, the Generalized Fluid System Simulation Program (GFSSP1) has been developed at NASA

  12. Fluid–fluid coexistence in colloidal systems with short-ranged strongly directional attraction

    NARCIS (Netherlands)

    Kern, N.; Frenkel, D.

    2003-01-01

    We present a systematic numerical study of the phase behavior of square-well fluids with a "patchy" short-ranged attraction. In particular, we study the effect of the size and number of attractive patches on the fluid–fluid coexistence. The model that we use is a generalization of the hard sphere

  13. Numerical study of coupled fluid-structure interaction for combustion system

    NARCIS (Netherlands)

    Khatir, Z.; Pozarlik, Artur Krzysztof; Cooper, R.K.; Watterson, J.W.; Kok, Jacobus B.W.

    2007-01-01

    The computation of fluid–structure interaction (FSI) problems requires solving simultaneously the coupled fluid and structure equations. A partitioned approach using a volume spline solution procedure is applied for the coupling of fluid dynamics and structural dynamics codes. For comparative study,

  14. Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations

    Directory of Open Access Journals (Sweden)

    Romero EL

    2013-08-01

    Full Text Available Eder Lilia Romero, Maria Jose Morilla Nanomedicine Research Program, Department of Science and Technology, National University of Quilmes, Bernal, Buenos Aires, Argentina Abstract: Vesicles that are specifically designed to overcome the stratum corneum barrier in intact skin provide an efficient transdermal (systemic or local drug delivery system. They can be classified into two main groups according to the mechanisms underlying their skin interaction. The first group comprises those possessing highly deformable bilayers, achieved by incorporating edge activators to the bilayers or by mixing with certain hydrophilic solutes. The vesicles of this group act as drug carriers that penetrate across hydrophilic pathways of the intact skin. The second group comprises those possessing highly fluid bilayers, owing to the presence of permeation enhancers. The vesicles of this group can act as carriers of drugs that permeate the skin after the barrier of the stratum corneum is altered because of synergistic action with the permeation enhancers contained in the vesicle structure. We have included a detailed overview of the different mechanisms of skin interaction and discussed the most promising preclinical applications of the last five years of Transfersomes® (IDEA AG, Munich, Germany, ethosomes, and invasomes as carriers of antitumoral and anti-inflammatory drugs applied by the topical route. Keywords: Transfersomes, ethosomes, antitumoral, anti-inflammatory, topical delivery

  15. Investigation of (n,γ) reactions in fissionable fluids in a hybrid reactor system

    Energy Technology Data Exchange (ETDEWEB)

    Guenay, Mehtap [Inoenue Univ., Malatya (Turkey). Physics Dept.

    2014-06-15

    In this study, the effect of (n,γ) reactions in spent fuel-grade (SFG)-PuO{sub 2}, UO{sub 2}, NpO{sub 2} and UCO contents was investigated in a designed hybrid reactor system. In this system, the molten salt-heavy metal mixtures 93 - 85 % Li{sub 20}Sn{sub 80} + 5 % SFG-PuO{sub 2} and 2 - 10 % UO{sub 2}, 93 - 85 % Li{sub 20}Sn{sub 80} + 5 % SFG-PuO{sub 2} and 2 - 10 % NpO{sub 2}, 93 - 85 % Li{sub 20}Sn{sub 80} + 5 % SFG-PuO{sub 2} and 2 - 10 % UCO were used as fluids. Beryllium (Be) is used as neutron multiplier by (n,2n) reactions. Thence, a Be zone with a width of 3 cm was used in order to contribute on fissile fuel breeding between the liquid first wall and blanket. (n,γ) reactions were calculated in the liquid first wall, blanket and shield zones, which SFG-PuO{sub 2}, UO{sub 2}, NpO{sub 2} and UCO contents. 9Cr2WVTa ferritic steel with the width of 4 cm was used as the structural material. Three-dimensional nucleonic calculations were performed using the most recent version MCNPX-2.7.0 the Monte Carlo code and nuclear data library ENDF/B-VII.0. (orig.)

  16. A mixed method Poisson solver for three-dimensional self-gravitating astrophysical fluid dynamical systems

    Science.gov (United States)

    Duncan, Comer; Jones, Jim

    1993-01-01

    A key ingredient in the simulation of self-gravitating astrophysical fluid dynamical systems is the gravitational potential and its gradient. This paper focuses on the development of a mixed method multigrid solver of the Poisson equation formulated so that both the potential and the Cartesian components of its gradient are self-consistently and accurately generated. The method achieves this goal by formulating the problem as a system of four equations for the gravitational potential and the three Cartesian components of the gradient and solves them using a distributed relaxation technique combined with conventional full multigrid V-cycles. The method is described, some tests are presented, and the accuracy of the method is assessed. We also describe how the method has been incorporated into our three-dimensional hydrodynamics code and give an example of an application to the collision of two stars. We end with some remarks about the future developments of the method and some of the applications in which it will be used in astrophysics.

  17. Fluid-structure interaction analysis of annular seals and rotor systems in multi-stage pumps

    International Nuclear Information System (INIS)

    Jiang, Qinglei; Zhai, Lulu; Wang, Leqin; Wu, Dazhuan

    2013-01-01

    Annular seals play an important role in determining the vibrational behavior of rotors in multi-stage pumps. To determine the critical speeds and unbalanced responses of rotor systems which consider annular seals, a fluid-structure interaction (FSI) method was developed, and the numerical method was verified by experiments conducted on a model rotor. In a typical FSI process, rotor systems are modeled based on a node-element method, and the motion equations are expressed in a type of matrix. To consider the influence of annular seals, dynamic coefficients of annular seals were introduced into the motion equations through matrix transformation. The test results of the model rotor showed good agreement with the calculated results. Based on the FSI method proposed here, the governing equations of annular seals were solved in two different ways. The results showed that the Childs method is more accurate in predicting a rotor's critical speed. The critical speeds of the model rotor were calculated at different clearance sizes and length/diameter ratios. Tilting coefficients of long seals were added to the dynamic coefficients to consider the influence of tilting. The critical speeds reached their maximum value when the L/D ratio was around 1.25, and tilting enhanced the rotor's stability when long annular seals were located in either end of the shaft.

  18. Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases

    Directory of Open Access Journals (Sweden)

    Čakić Saša

    2009-01-01

    Full Text Available Gingival crevicular fluid (GCF can be found in the physiologic space (gingival sulcus, as well as in the pathological space (gingival pocket or periodontal pocket between the gums and teeth. In the first case it is a transudate, in the second an exudate. The constituents of GCF originate from serum, gingival tissues, and from both bacterial and host response cells present in the aforementioned spaces and the surrounding tissues. The collection and analysis of GCF are the noninvasive methods for the evaluation of host response in periodontal disease. These analyses mainly focus on inflammatory markers, such as prostaglandin E2, neutrophil elastase and β-glucuronidase, and on the marker of cellular necrosis - aspartat aminotransferase. Further, the analysis of inflammatory markers in the GCF may assist in defining how certain systemic diseases (e.g., diabetes mellitus can modify periodontal disease, and how peridontal disease can influence certain systemic disorders (atherosclerosis, preterm delivery, diabetes mellitus and some chronic respiratory diseases. Major factors which influence the results obtained from the analyses of GCF are not only the methods of these analyses, but the method of GCF collection as well. As saliva collection is less technique-sensitive than GCF collection, some constituents of saliva which originate from the GCF can be analyzed as more amenable to chairside utilization.

  19. Investigation of (n,γ) reactions in fissionable fluids in a hybrid reactor system

    International Nuclear Information System (INIS)

    Guenay, Mehtap

    2014-01-01

    In this study, the effect of (n,γ) reactions in spent fuel-grade (SFG)-PuO 2 , UO 2 , NpO 2 and UCO contents was investigated in a designed hybrid reactor system. In this system, the molten salt-heavy metal mixtures 93 - 85 % Li 20 Sn 80 + 5 % SFG-PuO 2 and 2 - 10 % UO 2 , 93 - 85 % Li 20 Sn 80 + 5 % SFG-PuO 2 and 2 - 10 % NpO 2 , 93 - 85 % Li 20 Sn 80 + 5 % SFG-PuO 2 and 2 - 10 % UCO were used as fluids. Beryllium (Be) is used as neutron multiplier by (n,2n) reactions. Thence, a Be zone with a width of 3 cm was used in order to contribute on fissile fuel breeding between the liquid first wall and blanket. (n,γ) reactions were calculated in the liquid first wall, blanket and shield zones, which SFG-PuO 2 , UO 2 , NpO 2 and UCO contents. 9Cr2WVTa ferritic steel with the width of 4 cm was used as the structural material. Three-dimensional nucleonic calculations were performed using the most recent version MCNPX-2.7.0 the Monte Carlo code and nuclear data library ENDF/B-VII.0. (orig.)

  20. Numerical investigation on thermal and fluid dynamic behaviors of solar chimney building systems

    International Nuclear Information System (INIS)

    Manca, O.; Nardini, S.; Romano, P.; Mihailov, E.

    2013-01-01

    Full text: Buildings as big energy-consuming systems require large amount of energy to operate. Globally, buildings are responsible for approximately 40% of total world annual energy consumption. Sustainable buildings with renewable energy systems are trying to operate independently without consumption of conventional resources. Renewable energy is a significant approach to reduce resource consumption in sustainable building. A solar chimney is essentially divided into two parts, one - the solar air heater (collector) and second - the chimney. Two configurations of solar chimney are usually used: vertical solar chimney with vertical absorber geometry, and roof solar chimney. For vertical solar chimney, vertical glass is used to gain solar heat. Designing a solar chimney includes height, width and depth of cavity, type of glazing, type of absorber, and inclusion of insulation or thermal mass. Besides these system parameters, other factors such as the location, climate, and orientation can also affect its performance. In this paper a numerical investigation on a prototypal solar chimney system integrated in a south facade of a building is presented. The analysis is carried out on a three-dimensional model in air flow and the governing equations are given in terms of k-s turbulence model. Two geometrical configurations are investigated: 1) a channel with vertical parallel walls and 2) a channel with principal walls one vertical and the other inclined. The problem is solved by means of the commercial code Ansys-Fluent and the results are performed for a uniform wall heat flux on the vertical wall is equal to 300 and 600 W/m2. Results are given in terms of wall temperature distributions, air velocity and temperature fields and transversal profiles in order to evaluate the differences between the two base configurations and thermal and fluid dynamic behaviors. Further, the ground effect on thermal performances is examined. key words: mathematical modeling, solar chimney

  1. Design of Accumulators and Liquid/Gas Charging of Single Phase Mechanically Pumped Fluid Loop Heat Rejection Systems

    Science.gov (United States)

    Bhandari, Pradeep; Dudik, Brenda; Birur, Gajanana; Karlmann, Paul; Bame, David; Mastropietro, A. J.

    2012-01-01

    For single phase mechanically pumped fluid loops used for thermal control of spacecraft, a gas charged accumulator is typically used to modulate pressures within the loop. This is needed to accommodate changes in the working fluid volume due to changes in the operating temperatures as the spacecraft encounters varying thermal environments during its mission. Overall, the three key requirements on the accumulator to maintain an appropriate pressure range throughout the mission are: accommodation of the volume change of the fluid due to temperature changes, avoidance of pump cavitation and prevention of boiling in the liquid. The sizing and design of such an accumulator requires very careful and accurate accounting of temperature distribution within each element of the working fluid for the entire range of conditions expected, accurate knowledge of volume of each fluid element, assessment of corresponding pressures needed to avoid boiling in the liquid, as well as the pressures needed to avoid cavitation in the pump. The appropriate liquid and accumulator strokes required to accommodate the liquid volume change, as well as the appropriate gas volumes, require proper sizing to ensure that the correct pressure range is maintained during the mission. Additionally, a very careful assessment of the process for charging both the gas side and the liquid side of the accumulator is required to properly position the bellows and pressurize the system to a level commensurate with requirements. To achieve the accurate sizing of the accumulator and the charging of the system, sophisticated EXCEL based spreadsheets were developed to rapidly come up with an accumulator design and the corresponding charging parameters. These spreadsheets have proven to be computationally fast and accurate tools for this purpose. This paper will describe the entire process of designing and charging the system, using a case study of the Mars Science Laboratory (MSL) fluid loops, which is en route to

  2. Effect of initial fluid-system pressures on the behavior of a rupture-disc pressure-relief device

    International Nuclear Information System (INIS)

    Hsieh, B.J.; Shin, Y.W.; Kot, C.A.

    1983-01-01

    Rupture disc assemblies are used in piping network systems as a pressure-relief device to protect the system from being exposed to excess pressures. Among the various disc assemblies, the reverse-buckling type is chosen for application in the Clinch River Breeder Reactor. This rupture-disc assembly consists of a portion of a thin spherical shell with its convex side subjected to the fluid system. The reverse-buckling type rupture disc assemblies have been used successfully in environments where the fluid is gas, i.e. highly compressible, and their performances have been judged as adequate in the liquid environment. To analyze the piping system, an analysis method is needed taking into consideration of the fluid/disc interaction, the nonlinear dynamic buckling phenomenon of the disc, and the possible cavitation of the fluid. A computer code SWAAM-I had been written at the Components Technology Division, Argonne National Laboratory. Among its many functions, one is to compute the response of 1-dimensional pressure pulse propagation including the effects of many different types of boundary conditions and possible pipe plasticity

  3. Thermal Protection System Cavity Heating for Simplified and Actual Geometries Using Computational Fluid Dynamics Simulations with Unstructured Grids

    Science.gov (United States)

    McCloud, Peter L.

    2010-01-01

    Thermal Protection System (TPS) Cavity Heating is predicted using Computational Fluid Dynamics (CFD) on unstructured grids for both simplified cavities and actual cavity geometries. Validation was performed using comparisons to wind tunnel experimental results and CFD predictions using structured grids. Full-scale predictions were made for simplified and actual geometry configurations on the Space Shuttle Orbiter in a mission support timeframe.

  4. Informatic system for a global tissue-fluid biorepository with a graph theory-oriented graphical user interface

    NARCIS (Netherlands)

    Butler, William E.; Atai, Nadia; Carter, Bob; Hochberg, Fred

    2014-01-01

    The Richard Floor Biorepository supports collaborative studies of extracellular vesicles (EVs) found in human fluids and tissue specimens. The current emphasis is on biomarkers for central nervous system neoplasms but its structure may serve as a template for collaborative EV translational studies

  5. Dynamics of pleural fluid effusion and chylothorax in the fetus and newborn: role of the lymphatic system.

    Science.gov (United States)

    Bellini, C; Ergaz, Z; Boccardo, F; Bellini, T; Campisi, C C; Bonioli, E; Ramenghi, L A

    2013-06-01

    Pleural fluid effusion particularly chylothorax is a relatively rare occurrence in the newborn, but when it occurs it is often life-threatening. In this article, we describe and illustrate the morphologic features of the visceral and parietal pleura including pleural lymphatics and the physiology and pathophysiology of pleural fluid balance. The role and function of the lymphatic system in controlling the volume and composition of pleural liquid are detailed and a conceptual scheme presented. Finally, the crucial role of inadequate lymphatic drainage (either functional overload from an imbalance in Starling forces or mechanical insufficiency from lymphatic dysplasia) is emphasized.

  6. Coupling Fluid Dynamics and Multiphase Disequilibria: Applications to Eutectic and Peritectic Systems

    Science.gov (United States)

    Tweed, L. E. L.; Spiegelman, M. W.; Kelemen, P. B.

    2017-12-01

    Computational thermodynamics has yielded great insights into petrological processes. However, on its own it cannot capture the inherently dynamic nature of many of these processes which depend on the interaction between time-dependent processes including advection, diffusion and chemical reaction. To understand this interplay, and to move away from a purely equilibrium view, requires the integration of computational thermodynamics and fluid mechanics. A key aspect of doing this is the treatment of chemical reactions as time-dependent, irreversible processes. Such a development is integral to understanding a host of petrological questions from the open system evolution of magma chambers to the dynamics of melt migration beneath mid-ocean ridges and flux melting of the mantle wedge in subduction zones. A simple thermodynamically consistent reactive model is developed that can be integrated with conservation equations for mass, momentum and energy. The model rests on the thermodynamic characterization of an independent set of reactions and has the advantage of being completely general and easily extensible to systems comprising multiple solid and liquid phases. The underlying theory is described in detail in another contribution in this session. Here we apply the framework to experimentally constrained simple systems of petrological interest including the fo-qz binary and the fo-qz-k2o ternary. These systems contain a variety of phase topologies including eutectic and peritectic reactions. As the model allows for the seamless exhaustion and stabilization of phases, we can explore the effect that these discontinuous changes have on the compositional and dynamic evolution of the system. To do this we track how the systems respond to sudden changes in intensive variables that perturb them from equilibrium. Such changes are rife in crustal magmatic systems. Simulations for decompression melting are also run to explore the interplay between reactive and advective fluxes

  7. Computational fluid dynamic (CFD) analysis on ALUDRA SR-10 UAV with parachute recovery system

    Science.gov (United States)

    Saim, R.; Mohd, S.; Shamsudin, S. S.; Zulkifli, M. F.; Omar, Z.; Subari@Rahmat, Z.; Masrom, M. F. Mohd; Zaki, Y.

    2017-09-01

    In an operation, belly landing is mostly applied as recovery method especially on research Unmanned Aerial Vehicle (UAV) such as Aludra SR-10. This type of landing method may encounter tough landing on hard soil and gravel which create high impact load on the aircraft. The impact may cause structural or system damage which costly to be repaired. Nowadays, Parachute Recovery System (PRS) recently used in numerous different tasks such as landing purpose to replace belly landing technique. Parachute use in this system to slow down flying or falling UAV to a safe landing by opening the canopy to increase aerodynamic drag. This paper was described the Computational Fluid Dynamic (CFD) analysis on ALUDRA SR-10 model with two different conditions i.e. the UAV equipped with and without parachute in order to identify the changes of aerodynamic characteristics. This simulation studies using solid models of aircraft and hemisphere parachute and was carried out by using ANSYS 16.0 Fluent under steady and turbulent flow and was modelled using the k-epsilon (k-ε) turbulence model. This simulation was limited to determine the drag force and drag coefficient. The obtained result showed that implementation of parachute increase 0.25 drag coefficient of the aircraft that is from 0.93 to 1.18. Subsequent to the reduction of descent rate caused by the parachute, the drag force of the aircraft increase by 0.76N. These increasing of drag force of the aircraft will produce lower terminal velocity which is expected to reduce the impact force on the aircraft during landing.

  8. Summary of [alpha]-FLOW, a general purpose three-dimensional fluid analyzing system. Han[prime]yo sanjigen ryutai kaiseki system [alpha]-FLOW no gaiyo

    Energy Technology Data Exchange (ETDEWEB)

    Koike, H [Fuji Research Institute Corporation, Tokyo (Japan)

    1992-08-01

    The [alpha]-FLOW is a three-dimensional fluid analyzing software developed from cooperations among research institutes of private business companies and universities in Japan under the assistance from the Ministry of International Trade and Industry. This paper describes its summary and features. The system is a discrete system utilizing a supercomputer and a work station. The analysis modules incorporated in the system include those for non-compressive fluid analysis, compressive fluid analysis, analysis of non-compressive fluid including free surface, analysis of flows including combustion and chemical reactions, substance migration analysis, and heat transfer analysis. It has a feature that even non-specialists can analyze fluids easily as a result of the development of an expert system to support the numerical analysis. Development of the input data preparing system enables to utilize the work station to process from shape modeling to grid generation, and from inputting analyzing condition data to calculating the flows and outputting the calculation result, all in dialogue modes. An open architecture was adopted. 27 refs., 7 figs., 10 tabs.

  9. Present State and Future Developments in Mechatronics and it's Influence on Fluid Power Systems

    DEFF Research Database (Denmark)

    Christensen, Georg Kronborg; Zhou, Jianjun; Conrad, Finn

    1998-01-01

    with electronics, software and mechanics. This synergetic integration is often called Mechatronics.The topic which is rather widespread will be treated in three sections: I) General overview of mechatronics and fluid power. In this section the general trends of mechatronics in fluid power is considered by relating...... trends in the neighbouring fields of software and electronic hardware to fluid power developments. II) Mechatronic case stories from IKS In this section the results of a conceptual design study : "Design of a frequency converter based hydraulic power supply" is presented together with a more detailed...

  10. Ionic liquids as heat transfer fluids: comparison with known systems, possible applications, advantages and disadvantages

    International Nuclear Information System (INIS)

    Chernikova, E A; Glukhov, L M; Krasovskiy, V G; Kustov, L M; Vorobyeva, M G; Koroteev, A A

    2015-01-01

    The practical aspects and prospects of application of ionic liquids as heat transfer fluids are discussed. The physicochemical properties of ionic liquids (heat capacity, thermal conductivity, thermal and radiation stability, viscosity, density, saturated vapour pressure and corrosion activity) are compared with the properties of some commercial heat transfer fluids. The issues of toxicity of ionic liquids are considered. Much attention is paid to known organosilicon heat transfer fluids, which are considered to have much in common with ionic liquids in the set of properties and are used in the review as reference materials. The bibliography includes 132 references

  11. Biogenic methane leakage on the Aquitaine Shelf: fluid system characterization from source to emission

    Science.gov (United States)

    Michel, Guillaume; Dupré, Stéphanie; Baltzer, Agnès; Imbert, Patrice; Ehrhold, Axel; Battani, Anne; Deville, Eric

    2017-04-01

    The recent discovery of biogenic methane emissions associated with methane-derived authigenic carbonate mounds along the Aquitaine Shelf edge offshore SW France (140 to 220 m water depth) questions about the initiation and temporal evolution of this fluid system (80 km N-S and 8 km E-W). Based on a multi-data study (including multibeam echosounder, subbottom profiler, single channel sparker seismic, 80 traces air gun seismic data and well cuttings and logs), different scenarii are proposed for the organic matter source levels and migration pathways of the methane. Several evidence of the presence of gas are observed on seismic data and interpreted to be linked to the biogenic system. Single channel sparker seismic lines exhibit an acoustic blanking (between 75-100 ms TWT below seafloor and the first multiple) below the present-day seepage area and westwards up to 8 km beyond the shelf-break. An air gun seismic line exhibits chaotic reflections along 8 km below the seepage area from the seabed down to 700 ms TWT below seafloor. Based on 1) the local geothermal gradient about 26 °C/km and 2) the window for microbial methanogenesis ranging from 4 to 56 °C, the estimation of the bottom limit for biogenic generation window is about 1.5 km below seafloor. Cuttings from 3 wells of the area within the methanogenesis window show average TOC (Total Organic Carbon) of 0.5 %; however, one well shows some coal levels with 30-35 % TOC in the Oligocene between 1490 and 1540 m below seafloor. Geochemical analysis on crushed cuttings evidenced heavy hydrocarbons up to mid-Paleogene, while shallower series did not evidence any. In the first scenario, we propose that methane is sourced from the Neogene prograding system. The 0.5% average TOC is sufficient to generate a large volume of methane over the thickness of this interval (up to 1 km at the shelf break area). In the second scenario, methane would be sourced from the Oligocene coals; however their spatial extension with regard

  12. A computational fluid dynamics approach to nucleation in the water-sulfuric acid system.

    Science.gov (United States)

    Herrmann, E; Brus, D; Hyvärinen, A-P; Stratmann, F; Wilck, M; Lihavainen, H; Kulmala, M

    2010-08-12

    This study presents a computational fluid dynamics modeling approach to investigate the nucleation in the water-sulfuric acid system in a flow tube. On the basis of an existing experimental setup (Brus, D.; Hyvärinen, A.-P.; Viisanen, Y.; Kulmala, M.; Lihavainen, H. Atmos. Chem. Phys. 2010, 10, 2631-2641), we first establish the effect of convection on the flow profile. We then proceed to simulate nucleation for relative humidities of 10, 30, and 50% and for sulfuric acid concentration between 10(9) to 3 x 10(10) cm(-3). We describe the nucleation zone in detail and determine how flow rate and relative humidity affect its characteristics. Experimental nucleation rates are compared to rates gained from classical binary and kinetic nucleation theory as well as cluster activation theory. For low RH values, kinetic theory yields the best agreement with experimental results while binary nucleation best reproduces the experimental nucleation behavior at 50% relative humidity. Particle growth is modeled for an example case at 50% relative humidity. The final simulated diameter is very close to the experimental result.

  13. Application of computational fluid dynamics (CFD) simulation in a vertical axis wind turbine (VAWT) system

    Science.gov (United States)

    Kao, Jui-Hsiang; Tseng, Po-Yuan

    2018-01-01

    The objective of this paper is to describe the application of CFD (Computational fluid dynamics) technology in the matching of turbine blades and generator to increase the efficiency of a vertical axis wind turbine (VAWT). A VAWT is treated as the study case here. The SST (Shear-Stress Transport) k-ω turbulence model with SIMPLE algorithm method in transient state is applied to solve the T (torque)-N (r/min) curves of the turbine blades at different wind speed. The T-N curves of the generator at different CV (constant voltage) model are measured. Thus, the T-N curves of the turbine blades at different wind speed can be matched by the T-N curves of the generator at different CV model to find the optimal CV model. As the optimal CV mode is selected, the characteristics of the operating points, such as tip speed ratio, revolutions per minute, blade torque, and efficiency, can be identified. The results show that, if the two systems are matched well, the final output power at a high wind speed of 9-10 m/s will be increased by 15%.

  14. Study on effects of turbulence promoter on fluid mixing in T-junction piping system

    International Nuclear Information System (INIS)

    Nagao, Akihiro; Hibara, Hideki; Ochi, Junji; Muramatsu, Toshiharu

    2004-07-01

    Flows in T-junction piping system with turbulence promoter have been investigated experimentally using flow visualization techniques (the dye injection method) and velocity measurement by LDV. Effects of turbulent promoter on characteristics of fluid mixing and thermal-striping phenomena are examined. From the experiment, following results are obtained. (1) Arch vortex is formed further than the case without promoter in the upstream station and is rapidly transported to the downstream direction. (2) Secondary flow induced in the cross section become stronger and the diffusion of axial momentum is promoted, as the height of turbulence promoter is higher. (3) Main flow deflects towards to the opposite side of branch pipe at the T-junction, as the height of turbulence promoter is higher, and as velocity ratio becomes smaller, and the flow continues to deflect to a considerably downstream station. (4) Velocity fluctuation is observed in the position where the vortex is formed, and it becomes a maximum at z/Dm=2. In the further downstream, velocity fluctuation decreases with the vortex breakdown, and it considerably remains to the downstream. (author)

  15. Light scattering studies of lower dimensional colloidal particle and critical fluid systems

    International Nuclear Information System (INIS)

    O'Sullivan, W.J.; Mockler, R.C.

    1984-09-01

    The authors have studied the response to compression of colloidal particle crystals in monolayers on the surface of water. The crystals deform elastically as the crystals are compressed in a Langmuir trough from a lattice spacing of ten microns to spacings less than two microns. A phase transition to a close packed triangular lattice phase occurs at very high densities, when the attractive van der Waals/steric interations between particles dominate. The authors have found that the aggregates formed, when a colloidal particle monolayer coagulates following switching off of the repulsive electric dipole-dipole interactions, show scale invariance with a fractal dimension consistent with the prediction of a theory of diffusion limited aggregation in two dimensions. The authors have made progress toward the development of a computer processed array detector-spectrometer to be used in studies of melting and crystallization of two dimensional colloidal particle films. Stable black bilipid membranes have been produced, both spherical and planar, with and without embedded microparticles. We have modified our heterodyne autocorrelation spectrometer, used for studies of the dynamic response of critical fluid films, to enable us to measure the intensity autocorrelation of light scattered at forward angles. Rayleigh linewidth data has been gathered from a 1.9 micron film of a 2,6-lutidine+water critical mixture, taken at a scattering angle of ten degrees. The preliminary results indicate that the film dynamical response remains that of an equivalent three dimensional system, in apparent disgreement with recent theoretical predictions of Calvo and Ferrell

  16. Cellular Biotechnology Operations Support Systems-Fluid Dynamics Investigation (CBOSS-FDI)

    Science.gov (United States)

    2003-01-01

    Aboard the International Space Station (ISS), the Tissue Culture Module (TCM) is the stationary bioreactor vessel in which cell cultures grow. However, for the Cellular Biotechnology Operations Support Systems-Fluid Dynamics Investigation (CBOSS-FDI), color polystyrene beads are used to measure the effectiveness of various mixing procedures. Uniform mixing is a crucial component of CBOSS experiments involving the immune response of human lymphoid cell suspensions. In this picture, the beads are trapped in the injection port shortly after injection. Swirls of beads indicate, event to the naked eye, the contents of the TCM are not fully mixed. The beads are similar in size and density to human lymphoid cells. The goal is to develop procedures that are both convenient for the flight crew and are optimal in providing uniform and reproducible mixing of all components, including cells. The average bead density in a well mixed TCM will be uniform, with no bubbles, and it will be measured using the absorption of light

  17. Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid

    Science.gov (United States)

    Pentsova, Elena I.; Shah, Ronak H.; Tang, Jiabin; Boire, Adrienne; You, Daoqi; Briggs, Samuel; Omuro, Antonio; Lin, Xuling; Fleisher, Martin; Grommes, Christian; Panageas, Katherine S.; Meng, Fanli; Selcuklu, S. Duygu; Ogilvie, Shahiba; Distefano, Natalie; Shagabayeva, Larisa; Rosenblum, Marc; DeAngelis, Lisa M.; Viale, Agnes; Berger, Michael F.

    2016-01-01

    Purpose Cancer spread to the central nervous system (CNS) often is diagnosed late and is unresponsive to therapy. Mechanisms of tumor dissemination and evolution within the CNS are largely unknown because of limited access to tumor tissue. Materials and Methods We sequenced 341 cancer-associated genes in cell-free DNA from cerebrospinal fluid (CSF) obtained through routine lumbar puncture in 53 patients with suspected or known CNS involvement by cancer. Results We detected high-confidence somatic alterations in 63% (20 of 32) of patients with CNS metastases of solid tumors, 50% (six of 12) of patients with primary brain tumors, and 0% (zero of nine) of patients without CNS involvement by cancer. Several patients with tumor progression in the CNS during therapy with inhibitors of oncogenic kinases harbored mutations in the kinase target or kinase bypass pathways. In patients with glioma, the most common malignant primary brain tumor in adults, examination of cell-free DNA uncovered patterns of tumor evolution, including temozolomide-associated mutations. Conclusion The study shows that CSF harbors clinically relevant genomic alterations in patients with CNS cancers and should be considered for liquid biopsies to monitor tumor evolution in the CNS. PMID:27161972

  18. Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection

    Directory of Open Access Journals (Sweden)

    Bestetti Arabella

    2010-06-01

    Full Text Available Abstract HIV-1 invades the central nervous system (CNS in the context of acute infection, persists thereafter in the absence of treatment, and leads to chronic intrathecal immunoactivation that can be measured by the macrophage activation marker, neopterin, in cerebrospinal fluid (CSF. In this review we describe our experience with CSF neopterin measurements in 382 untreated HIV-infected patients across the spectrum of immunosuppression and HIV-related neurological diseases, in 73 untreated AIDS patients with opportunistic CNS infections, and in 233 treated patients. In untreated patients, CSF neopterin concentrations are almost always elevated and increase progressively as immunosuppression worsens and blood CD4 cell counts fall. However, patients with HIV dementia exhibit particularly high CSF neopterin concentrations, above those of patients without neurological disease, though patients with CNS opportunistic infections, including CMV encephalitis and cryptococcal meningitis, also exhibit high levels of CSF neopterin. Combination antiretroviral therapy, with its potent effect on CNS HIV infection and CSF HIV RNA, mitigates both intrathecal immunoactivation and lowers CSF neopterin. However, despite suppression of plasma and CSF HIV RNA to below the detection limits of clinical assays ( Although nonspecific, CSF neopterin can serve as a useful biomarker in the diagnosis of HIV dementia in the setting of confounding conditions, in monitoring the CNS inflammatory effects of antiretroviral treatment, and give valuable information to the cause of ongoing brain injury.

  19. Computer simulation of thermal and fluid systems for MIUS integration and subsystems test /MIST/ laboratory. [Modular Integrated Utility System

    Science.gov (United States)

    Rochelle, W. C.; Liu, D. K.; Nunnery, W. J., Jr.; Brandli, A. E.

    1975-01-01

    This paper describes the application of the SINDA (systems improved numerical differencing analyzer) computer program to simulate the operation of the NASA/JSC MIUS integration and subsystems test (MIST) laboratory. The MIST laboratory is designed to test the integration capability of the following subsystems of a modular integrated utility system (MIUS): (1) electric power generation, (2) space heating and cooling, (3) solid waste disposal, (4) potable water supply, and (5) waste water treatment. The SINDA/MIST computer model is designed to simulate the response of these subsystems to externally impressed loads. The computer model determines the amount of recovered waste heat from the prime mover exhaust, water jacket and oil/aftercooler and from the incinerator. This recovered waste heat is used in the model to heat potable water, for space heating, absorption air conditioning, waste water sterilization, and to provide for thermal storage. The details of the thermal and fluid simulation of MIST including the system configuration, modes of operation modeled, SINDA model characteristics and the results of several analyses are described.

  20. Seismic properties of fluid bearing formations in magmatic geothermal systems: can we directly detect geothermal activity with seismic methods?

    Science.gov (United States)

    Grab, Melchior; Scott, Samuel; Quintal, Beatriz; Caspari, Eva; Maurer, Hansruedi; Greenhalgh, Stewart

    2016-04-01

    Seismic methods are amongst the most common techniques to explore the earth's subsurface. Seismic properties such as velocities, impedance contrasts and attenuation enable the characterization of the rocks in a geothermal system. The most important goal of geothermal exploration, however, is to describe the enthalpy state of the pore fluids, which act as the main transport medium for the geothermal heat, and to detect permeable structures such as fracture networks, which control the movement of these pore fluids in the subsurface. Since the quantities measured with seismic methods are only indirectly related with the fluid state and the rock permeability, the interpretation of seismic datasets is difficult and usually delivers ambiguous results. To help overcome this problem, we use a numerical modeling tool that quantifies the seismic properties of fractured rock formations that are typically found in magmatic geothermal systems. We incorporate the physics of the pore fluids, ranging from the liquid to the boiling and ultimately vapor state. Furthermore, we consider the hydromechanics of permeable structures at different scales from small cooling joints to large caldera faults as are known to be present in volcanic systems. Our modeling techniques simulate oscillatory compressibility and shear tests and yield the P- and S-wave velocities and attenuation factors of fluid saturated fractured rock volumes. To apply this modeling technique to realistic scenarios, numerous input parameters need to be indentified. The properties of the rock matrix and individual fractures were derived from extensive literature research including a large number of laboratory-based studies. The geometries of fracture networks were provided by structural geologists from their published studies of outcrops. Finally, the physical properties of the pore fluid, ranging from those at ambient pressures and temperatures up to the supercritical conditions, were taken from the fluid physics

  1. Model Predictive Control of a Wave Energy Converter with Discrete Fluid Power Power Take-Off System

    Directory of Open Access Journals (Sweden)

    Anders Hedegaard Hansen

    2018-03-01

    Full Text Available Wave power extraction algorithms for wave energy converters are normally designed without taking system losses into account leading to suboptimal power extraction. In the current work, a model predictive power extraction algorithm is designed for a discretized power take of system. It is shown how the quantized nature of a discrete fluid power system may be included in a new model predictive control algorithm leading to a significant increase in the harvested power. A detailed investigation of the influence of the prediction horizon and the time step is reported. Furthermore, it is shown how the inclusion of a loss model may increase the energy output. Based on the presented results it is concluded that power extraction algorithms based on model predictive control principles are both feasible and favorable for use in a discrete fluid power power take-off system for point absorber wave energy converters.

  2. Informatic system for a global tissue-fluid biorepository with a graph theory-oriented graphical user interface

    OpenAIRE

    Butler, William E.; Atai, Nadia; Carter, Bob; Hochberg, Fred

    2014-01-01

    The Richard Floor Biorepository supports collaborative studies of extracellular vesicles (EVs) found in human fluids and tissue specimens. The current emphasis is on biomarkers for central nervous system neoplasms but its structure may serve as a template for collaborative EV translational studies in other fields. The informatic system provides specimen inventory tracking with bar codes assigned to specimens and containers and projects, is hosted on globalized cloud computing resources, and e...

  3. Computational Fluid Dynamics

    International Nuclear Information System (INIS)

    Myeong, Hyeon Guk

    1999-06-01

    This book deals with computational fluid dynamics with basic and history of numerical fluid dynamics, introduction of finite volume method using one-dimensional heat conduction equation, solution of two-dimensional heat conduction equation, solution of Navier-Stokes equation, fluid with heat transport, turbulent flow and turbulent model, Navier-Stokes solution by generalized coordinate system such as coordinate conversion, conversion of basic equation, program and example of calculation, application of abnormal problem and high speed solution of numerical fluid dynamics.

  4. Nuclear reactor core support incorporating also a cooling fluid flow system

    International Nuclear Information System (INIS)

    Pennell, W.E.

    1975-01-01

    A description is given of a core bearing plate with several modular intake units having cooling fluid intake openings on their lower extensions, and on their upper ends located above the bearing plate, at least one fuel assembly which is thus in communication with the area under the bearing plate through the modular intake unit. The means for introducing the cooling fluid into the reactor vessel area are located under the bearing plate. The lower ends of the modular intake have ribs arranged essentially on a plane and join together with openings provided between the seals, in such a manner that the ribs form a barrier. The cooling fluid intake openings are located above this barrier, so that the cooling fluid is compelled to cross it before penetrating into the modular intake units [fr

  5. Critical evaluation and comparison of fluid distribution systems for industrial scale expanded bed adsorption chromatography columns

    DEFF Research Database (Denmark)

    Arpanaei, Ayyoob; Heebøll-Nielsen, Anders; Hubbuch, Jürgen

    2008-01-01

    distributor at large scale were apparent: dead zones were present which could not be removed by increasing rotation rates or flow rates, and such changes led to a deterioration in hydrodynamic properties. In contrast, during fluid introduction through a rotating distributor no dead zones were observed....... The results imply that further improvement in distributor design is needed and careful attention should be given to the trade off between turbulence and adequate fluid distribution....

  6. Perspective: Differential dynamic microscopy extracts multi-scale activity in complex fluids and biological systems

    Science.gov (United States)

    Cerbino, Roberto; Cicuta, Pietro

    2017-09-01

    Differential dynamic microscopy (DDM) is a technique that exploits optical microscopy to obtain local, multi-scale quantitative information about dynamic samples, in most cases without user intervention. It is proving extremely useful in understanding dynamics in liquid suspensions, soft materials, cells, and tissues. In DDM, image sequences are analyzed via a combination of image differences and spatial Fourier transforms to obtain information equivalent to that obtained by means of light scattering techniques. Compared to light scattering, DDM offers obvious advantages, principally (a) simplicity of the setup; (b) possibility of removing static contributions along the optical path; (c) power of simultaneous different microscopy contrast mechanisms; and (d) flexibility of choosing an analysis region, analogous to a scattering volume. For many questions, DDM has also advantages compared to segmentation/tracking approaches and to correlation techniques like particle image velocimetry. The very straightforward DDM approach, originally demonstrated with bright field microscopy of aqueous colloids, has lately been used to probe a variety of other complex fluids and biological systems with many different imaging methods, including dark-field, differential interference contrast, wide-field, light-sheet, and confocal microscopy. The number of adopting groups is rapidly increasing and so are the applications. Here, we briefly recall the working principles of DDM, we highlight its advantages and limitations, we outline recent experimental breakthroughs, and we provide a perspective on future challenges and directions. DDM can become a standard primary tool in every laboratory equipped with a microscope, at the very least as a first bias-free automated evaluation of the dynamics in a system.

  7. A numerical simulation package for analysis of neutronics and thermal fluids of space nuclear power and propulsion systems

    International Nuclear Information System (INIS)

    Anghaie, S.; Feller, G.J.; Peery, S.D.; Parsley, R.C.

    1993-01-01

    A system of computer codes for engineering simulation and in-depth analysis of nuclear and thermal fluid design of nuclear thermal rockets is developed. The computational system includes a neutronic solver package, a thermal fluid solver package and a propellant and materials property package. The Rocket Engine Transient Simulation (ROCETS) system code is incorporated with computational modules specific to nuclear powered engines. ROCETS features a component based performance architecture that interfaces component modules into the user designed configuration, interprets user commands, creates an executable FORTRAN computer program, and executes the program to provide output to the user. Basic design features of the Pratt ampersand Whitney XNR2000 nuclear rocket concept and its operational performance are analyzed and simulated

  8. Influence of Vegetable Oil-Based Controlled Cutting Fluid Impinging Supply System on Micro Hardness in Machining of Ti-6Al-4V

    OpenAIRE

    Salah Gariani; Islam Shyha; Fawad Inam; Dehong Huo

    2017-01-01

    A controlled cutting fluid impinging supply system (CUT-LIST) was developed to deliver an accurate amount of cutting fluid into the machining zone via well-positioned coherent nozzles based on a calculation of the heat generated. The performance of the CUT-LIST was evaluated against a conventional flood cutting fluid supply system during step shoulder milling of Ti-6Al-4V using vegetable oil-based cutting fluid. In this paper, the micro-hardness of the machined surface was used as the main cr...

  9. Subseafloor fluid mixing and fossilized microbial life in a Cretaceous 'Lost City'-type hydrothermal system at the Iberian Margin

    Science.gov (United States)

    Klein, F.; Humphris, S. E.; Guo, W.; Schubotz, F.; Schwarzenbach, E. M.; Orsi, W.

    2015-12-01

    Subseafloor mixing of reduced hydrothermal fluids with seawater is believed to provide the energy and substrates needed to support autotrophic microorganisms in the hydrated oceanic mantle (serpentinite). Despite the potentially significant implications for the distribution of microbial life on Earth and other water-bearing planetary bodies, our understanding of such environments remains elusive. In the present study we examined fossilized microbial communities and fluid mixing processes in the subseafloor of a Cretaceous 'Lost City'-type hydrothermal system at the passive Iberia Margin (ODP Leg 149, Hole 897D). Brucite and calcite co-precipitated from mixed fluids ca. 65m below the Cretaceous palaeo-seafloor at temperatures of 32±4°C within steep chemical gradients (fO2, pH, CH4, SO4, ΣCO2, etc) between weathered, carbonate-rich serpentinite breccia and serpentinite. Mixing of oxidized seawater and strongly reducing hydrothermal fluid at moderate temperatures created conditions capable of supporting microbial activity within the oceanic basement. Dense microbial colonies are fossilized in brucite-calcite veins that are strongly enriched in organic carbon but depleted in 13C. We detected a combination of bacterial diether lipid biomarkers, archaeol and archaeal tetraethers analogous to those found in brucite-carbonate chimneys at the active Lost City hydrothermal field. The exposure of mantle rocks to seawater during the breakup of Pangaea fueled chemolithoautotrophic microbial communities at the Iberia Margin during the Cretaceous, possibly before the onset of seafloor spreading in the Atlantic. 'Lost City'-type serpentinization systems have been discovered at mid-ocean ridges, in forearc settings of subduction zones and at continental margins. It appears that, wherever they occur, they can support microbial life, even in deep subseafloor environments as demonstrated in the present study. Because equivalent systems have likely existed throughout most of Earth

  10. Mixing of fluids in hydrothermal ore-forming (Sn,W) systems: stable isotope and rare earth elements data

    Science.gov (United States)

    Sushchevskaya, T. M.; Popova, J. A.; Velivetskaya, T. A.; Ignatiev, A. V.; Matveeva, S. S.; Limantseva, O. A.

    2012-04-01

    Experimental and physico-chemical modeling data witness to important role of mixing of different type of fluids during tin and tungsten ore formation in hydrothermal systems. Mixing of magmatogeneous fluids, exsolved from granite melts, with exogenic, initially meteoric waters in hydrothermal ore-forming systems may change chemical composition of ore-forming fluid, causing cassiterite and/or wolframite precipitation (Heinrich, 1990; Sushchevskaya, Ryzhenko, 2002). We studied the process of genetically different fluids mixing for two economic Sn-W deposits, situated in the Iultin ore region (North-East of Russia, Chukotka Penninsula). The Iultin and Svetloe deposits are located in the apical parts of close situated leucogranite stocks, formed at the final stage of the Iultin complex emplacement. Both deposits are composed of a series of quartz veins among the flyschoid rocks (T 1-2), cut by the dikes (K1) of lamprophyre, granodiorite porphyre and alpite. The veins of the deposits are dominated by the productive quartz-wolframite-cassiterite-arsenopyrite-muscovite mineral assemblage. Topaz, beryl, fluorite, and albite occur sporadically. The later sulfide (loellingite-stannite-chalcopyrite) and quartz-fluorite-calcite assemblages show insignificant development. The preore quartz veinlets in host hornfels contain disseminated iron sulfides, chalcopyrite, muscovite. Isotopic (H, O, Ar) study of minerals, supplemented by oxygen isotope data of host granites and metamorphic rocks gave us possibility to conclude, that at the Iultin and the Svetloye deposits fluid mixing was fixed on the early stages of deposit formation and could be regarded as probable cause of metal (W, Sn) precipitation. During postore time the intensive involvement of isotopically light exogenic waters have changed: a) the initial character of oxygen isotope zonality; b) the initial hydrogen isotope composition of muscovites, up to meteoric calculated values for productive fluid (while the δ18O

  11. Electric fluid pump

    Science.gov (United States)

    Van Dam, Jeremy Daniel; Turnquist, Norman Arnold; Raminosoa, Tsarafidy; Shah, Manoj Ramprasad; Shen, Xiaochun

    2015-09-29

    An electric machine is presented. The electric machine includes a hollow rotor; and a stator disposed within the hollow rotor, the stator defining a flow channel. The hollow rotor includes a first end portion defining a fluid inlet, a second end portion defining a fluid outlet; the fluid inlet, the fluid outlet, and the flow channel of the stator being configured to allow passage of a fluid from the fluid inlet to the fluid outlet via the flow channel; and wherein the hollow rotor is characterized by a largest cross-sectional area of hollow rotor, and wherein the flow channel is characterized by a smallest cross-sectional area of the flow channel, wherein the smallest cross-sectional area of the flow channel is at least about 25% of the largest cross-sectional area of the hollow rotor. An electric fluid pump and a power generation system are also presented.

  12. Multi-fluid simulations of the coupled solar wind-magnetosphere-ionsphere system

    Science.gov (United States)

    Lyon, J.

    2011-12-01

    This paper will review recent work done with the multi-fluid version of the Lyon-Fedder-Mobarry (MF-LFM) global MHD simulation code. We will concentrate on O+ outflow from the ionosphere and its importance for magnetosphere-ionosphere (MI) coupling and also the importance of ionospheric conditions in determining the outflow. While the predominant method of coupling between the magnetosphere and ionosphere is electrodynamic, it has become apparent the mass flows from the ionosphere into the magnetosphere can have profound effects on both systems. The earliest models to attempt to incorporate this effect used very crude clouds of plasma near the Earth. The earliest MF-LFM results showed that depending on the details of the outflow - where, how much, how fast - very different magnetospheric responses could be found. Two approaches to causally driven models for the outflow have been developed for use in global simulations, the Polar Wind Outflow Model (PWOM), started at the Univ. of Michigan, and the model used by Bill Lotko and co-workers at Dartmouth. We will give a quick review of this model which is based on the empirical relation between outflow fluence and Poynting flux discovered by Strangeway. An additional factor used in this model is the precipitating flux of electrons, which is presumed to correlate with the scale height of the upwelling ions. parameters such as outflow speed and density are constrained by the total fluence. The effects of the outflow depend on the speed. Slower outflow tends to land in the inner magnetosphere increasing the strength of the ring current. Higher speed flow out in the tail. Using this model, simulations have shown that solar wind dynamic pressure has a profound effect on the amount of fluence. The most striking result has been the simulation of magnetospheric sawtooth events. We will discuss future directions for this research, emphasizing the need for better physical models for the outflow process and its coupling to the

  13. Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection.

    Science.gov (United States)

    Hagberg, Lars; Cinque, Paola; Gisslen, Magnus; Brew, Bruce J; Spudich, Serena; Bestetti, Arabella; Price, Richard W; Fuchs, Dietmar

    2010-06-03

    HIV-1 invades the central nervous system (CNS) in the context of acute infection, persists thereafter in the absence of treatment, and leads to chronic intrathecal immunoactivation that can be measured by the macrophage activation marker, neopterin, in cerebrospinal fluid (CSF). In this review we describe our experience with CSF neopterin measurements in 382 untreated HIV-infected patients across the spectrum of immunosuppression and HIV-related neurological diseases, in 73 untreated AIDS patients with opportunistic CNS infections, and in 233 treated patients.In untreated patients, CSF neopterin concentrations are almost always elevated and increase progressively as immunosuppression worsens and blood CD4 cell counts fall. However, patients with HIV dementia exhibit particularly high CSF neopterin concentrations, above those of patients without neurological disease, though patients with CNS opportunistic infections, including CMV encephalitis and cryptococcal meningitis, also exhibit high levels of CSF neopterin. Combination antiretroviral therapy, with its potent effect on CNS HIV infection and CSF HIV RNA, mitigates both intrathecal immunoactivation and lowers CSF neopterin. However, despite suppression of plasma and CSF HIV RNA to below the detection limits of clinical assays (<50 copies HIV RNA/mL), CSF neopterin often remains mildly elevated, indicating persistent low-level intrathecal immune activation and raising the important questions of whether this elevation is driven by continued CNS infection and whether it causes continued indolent CNS injury.Although nonspecific, CSF neopterin can serve as a useful biomarker in the diagnosis of HIV dementia in the setting of confounding conditions, in monitoring the CNS inflammatory effects of antiretroviral treatment, and give valuable information to the cause of ongoing brain injury.

  14. Structure-Preserving Methods for the Navier-Stokes-Cahn-Hilliard System to Model Immiscible Fluids

    KAUST Repository

    Sarmiento, Adel F.

    2017-12-03

    This work presents a novel method to model immiscible incompressible fluids in a stable manner. Here, the immiscible behavior of the flow is described by the incompressible Navier-Stokes-Cahn-Hilliard model, which is based on a diffuse interface method. We introduce buoyancy effects in the model through the Boussinesq approximation in a consistent manner. A structure-preserving discretization is used to guarantee the linear stability of the discrete problem and to satisfy the incompressibility of the discrete solution at every point in space by construction. For the solution of the model, we developed the Portable Extensible Toolkit for Isogeometric Analysis with Multi-Field discretizations (PetIGA-MF), a high-performance framework that supports structure-preserving spaces. PetIGA-MF is built on top of PetIGA and the Portable Extensible Toolkit for Scientific Computation (PETSc), sharing all their user-friendly, performance, and flexibility features. Herein, we describe the implementation of our model in PetIGA-MF and the details of the numerical solution. With several numerical tests, we verify the convergence, scalability, and validity of our approach. We use highly-resolved numerical simulations to analyze the merging and rising of droplets. From these simulations, we detailed the energy exchanges in the system to evaluate quantitatively the quality of our simulations. The good agreement of our results when compared against theoretical descriptions of the merging, and the small errors found in the energy analysis, allow us to validate our approach. Additionally, we present the development of an unconditionally energy-stable generalized-alpha method for the Swift-Hohenberg model that offers control over the numerical dissipation. A pattern formation example demonstrates the energy-stability and convergence of our method.

  15. Vibration isolation analysis of new design OEM damper for malaysia vehicle suspension system featuring MR fluid

    Science.gov (United States)

    Unuh, M. H.; Muhamad, P.; Norfazrina, H. M. Y.; Ismail, M. A.; Tanasta, Z.

    2018-01-01

    The applications of semi-active damper employing magnetorheological (MR) fluids keep increasing in fulfilling the demand to control undesired vibration effect. The aim of this study is to introduce the new design of damper for Malaysian vehicle model as well to evaluate its effectiveness in promoting comfort. The vibration isolation performance of the OEM damper featuring MR fluid was analysed physically under real road profile excitation experimentally. An experiment using quarter car rig suspension and LMS SCADAS Mobile was conducted to demonstrate the influence of current in controlling the characteristics of MR fluid in alter the damping behaviour under 5 cm bump impact. Subsequently, the displacement values were measured with respect to time. The new design OEM damper featuring MR fluid was validated by comparing the data with original equipment manufacturer (OEM) passive damper results under the same approach of testing. Comparison of numerical data of the new design OEM damper shown that it can reduce the excitation amplitude up to 40% compared to those obtained by OEM passive damper. Finally, the new design OEM damper featuring MR fluid has effectively isolated the disturbance from the road profile and control the output force.

  16. Thirteenth symposium on energy engineering sciences: Proceedings. Fluid/thermal processes, systems analysis and control

    International Nuclear Information System (INIS)

    1995-01-01

    The DOE Office of Basic Energy Sciences, of which Engineering Research is a component program, is responsible for the long-term mission-oriented research in the Department. Consistent with the DOE/BES mission, the Engineering Research Program is charged with the identification, initiation, and management of fundamental research on broad, generic topics addressing energy-related engineering problems. Its stated goals are: (1) to improve and extend the body of knowledge underlying current engineering practice so as to create new options for enhancing energy savings and production, for prolonging useful life of energy-related structures and equipment, and for developing advanced manufacturing technologies and materials processing with emphasis on reducing costs with improved industrial production and performance quality; and (2) to expand the store of fundamental concepts for solving anticipated and unforeseen engineering problems in the energy technologies. The meeting covered the following areas: (1) fluid mechanics 1--fundamental properties; (2) fluid mechanics 2--two phase flow; (3) thermal processes; (4) fluid mechanics 3; (5) process analysis and control; (6) fluid mechanics 4--turbulence; (7) fluid mechanics 5--chaos; (8) materials issues; and (9) plasma processes. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database

  17. Study on an alternating current electrothermal micropump for microneedle-based fluid delivery systems

    Science.gov (United States)

    Zhang, Rumi; Jullien, Graham A.; Dalton, Colin

    2013-07-01

    In this paper, we report on a modeling study of an AC electrothermal (ACET) micropump with high operating pressures as well as fast flow rates. One specific application area is for fluid delivery using microneedle arrays which require higher pressures and faster flow rates than have been previously reported with ACET devices. ACET is very suitable for accurate actuation and control of fluid flow, since the technique has been shown to be very effective in high conductivity fluids and has the ability to create a pulsation free flow. However, AC electrokinetic pumps usually can only generate low operating pressures of 1 to 100 Pa, where flow reversal is likely to occur with an external load. In order to realize a high performance ACET micropump for continuous fluid delivery, applying relatively high AC operating voltages (20 to 36 Vrms) to silicon substrate ACET actuators and using long serpentine channel allows the boosting of operating pressure as well as increasing the flow rates. Fast pumping flow rates (102-103 nl/s) and high operating pressures (1-12 kPa) can be achieved by applying both methods, making them of significant importance for continuous fluid delivery applications using microneedle arrays and other such biomedical devices.

  18. Thirteenth symposium on energy engineering sciences: Proceedings. Fluid/thermal processes, systems analysis and control

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    The DOE Office of Basic Energy Sciences, of which Engineering Research is a component program, is responsible for the long-term mission-oriented research in the Department. Consistent with the DOE/BES mission, the Engineering Research Program is charged with the identification, initiation, and management of fundamental research on broad, generic topics addressing energy-related engineering problems. Its stated goals are: (1) to improve and extend the body of knowledge underlying current engineering practice so as to create new options for enhancing energy savings and production, for prolonging useful life of energy-related structures and equipment, and for developing advanced manufacturing technologies and materials processing with emphasis on reducing costs with improved industrial production and performance quality; and (2) to expand the store of fundamental concepts for solving anticipated and unforeseen engineering problems in the energy technologies. The meeting covered the following areas: (1) fluid mechanics 1--fundamental properties; (2) fluid mechanics 2--two phase flow; (3) thermal processes; (4) fluid mechanics 3; (5) process analysis and control; (6) fluid mechanics 4--turbulence; (7) fluid mechanics 5--chaos; (8) materials issues; and (9) plasma processes. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  19. Fluid Inclusion Analysis of other Host Minerals besides Quartz: Application to Granite-Related Quartz-Topaz Veins and Garnet Skarns in Porphyry Copper-Gold Ore Systems

    OpenAIRE

    Schlöglova, Katerina

    2018-01-01

    Fluid inclusions are the only available samples of paleo-fluids responsible for crystallization of hydrothermal minerals including ore phases. Analysis of fluid inclusions implicitly assumes that the inclusions have preserved their chemical composition since the time of their entrapment. There is, however, an increasing evidence from experimental work and analytical studies of natural samples showing that inclusions hosted in quartz – a ubiquitous host in many ore-forming systems – can experi...

  20. Hydrochemical Characteristics and Evolution of Geothermal Fluids in the Chabu High-Temperature Geothermal System, Southern Tibet

    Directory of Open Access Journals (Sweden)

    X. Wang

    2018-01-01

    Full Text Available This study defines reasonable reservoir temperatures and cooling processes of subsurface geothermal fluids in the Chabu high-temperature geothermal system. This system lies in the south-central part of the Shenzha-Xietongmen hydrothermal active belt and develops an extensive sinter platform with various and intense hydrothermal manifestations. All the geothermal spring samples collected systematically from the sinter platform are divided into three groups by cluster analysis of major elements. Samples of group 1 and group 3 are distributed in the central part and northern periphery of the sinter platform, respectively, while samples of group 2 are scattered in the transitional zone between groups 1 and 3. The hydrochemical characteristics show that the geothermal waters of the research area have generally mixed with shallow cooler waters in reservoirs. The reasonable reservoir temperatures and the mixing processes of the subsurface geothermal fluids could be speculated by combining the hydrochemical characteristics of geothermal springs, calculated results of the chemical geothermometers, and silica-enthalpy mixing models. Contour maps are applied to measured emerging temperatures, mass flow rates, total dissolved solids of spring samples, and reasonable subsurface temperatures. They indicate that the major cooling processes of the subsurface geothermal fluids gradually transform from adiabatic boiling to conduction from the central part to the peripheral belt. The geothermal reservoir temperatures also show an increasing trend. The point with the highest reservoir temperature (256°C appears in the east-central part of the research area, which might be the main up-flow zone. The cooling processes of the subsurface geothermal fluids in the research area can be shown on an enthalpy-chloride plot. The deep parent fluid for the Chabu geothermal field has a Cl− concentration of 290 mg/L and an enthalpy of 1550 J/g (with a water temperature of

  1. DNA - An integrated open-source optimization platform for thermo-fluid systems

    DEFF Research Database (Denmark)

    Pierobon, Leonardo; Wronski, Jorrit; Elmegaard, Brian

    2014-01-01

    This paper presents developments and new features added to the simulation tool Dynamic Network Analysis. This open-source software is the result of ongoing development at the Department of Mechanical Engineering, Technical University of Denmark since 1988. Ever since, it has been employed to model...... to extend the capabilities of the software, while at the same time decreasing computational time. Dynamic Network Analysis can now solve non-convex optimization problems by virtue of the fully-embedded genetic algorithm. Moreover, the thermophysical fluid property library has been extended with more than...... 110 fluids by interfacing CoolProp, a high-accuracy open-source property package for pure and pseudo-pure fluids, as well as humid air. Furthermore, the use as time integrator for other tools is demonstrated. The new features are unveiled in two case studies. The first example covers the optimization...

  2. A two-system, single-analysis, fluid-structure interaction technique for modelling abdominal aortic aneurysms.

    Science.gov (United States)

    Kelly, S C; O'Rourke, M J

    2010-01-01

    This work reports on the implementation and validation of a two-system, single-analysis, fluid-structure interaction (FSI) technique that uses the finite volume (FV) method for performing simulations on abdominal aortic aneurysm (AAA) geometries. This FSI technique, which was implemented in OpenFOAM, included fluid and solid mesh motion and incorporated a non-linear material model to represent AAA tissue. Fully implicit coupling was implemented, ensuring that both the fluid and solid domains reached convergence within each time step. The fluid and solid parts of the FSI code were validated independently through comparison with experimental data, before performing a complete FSI simulation on an idealized AAA geometry. Results from the FSI simulation showed that a vortex formed at the proximal end of the aneurysm during systolic acceleration, and moved towards the distal end of the aneurysm during diastole. Wall shear stress (WSS) values were found to peak at both the proximal and distal ends of the aneurysm and remain low along the centre of the aneurysm. The maximum von Mises stress in the aneurysm wall was found to be 408kPa, and this occurred at the proximal end of the aneurysm, while the maximum displacement of 2.31 mm occurred in the centre of the aneurysm. These results were found to be consistent with results from other FSI studies in the literature.

  3. On the use of semiempirical models of (solid + supercritical fluid) systems to determine solid sublimation properties

    International Nuclear Information System (INIS)

    Tabernero, Antonio; Martin del Valle, Eva M.; Galan, Miguel A.

    2011-01-01

    Research highlights: → We propose a method to determine sublimation properties of solids. → Low deviations were produced calculating sublimation enthalpies and pressures. → It is a required step to determine the vaporization enthalpy of the solid. → It is possible to determine solid properties using semiempirical models solid-SCF. - Abstract: Experimental solubility data of solid-supercritical fluids have significantly increased in the last few years, and semiempirical models are emerging as one of the best choices to fit this type of data. This work establishes a methodology to calculate sublimation pressures using this type of equations. It requires the use of Bartle's equation to model equilibria data solid-supercritical fluids with the aim of determining the vaporization enthalpy of the compound. Using this method, low deviations were obtained by calculating sublimation pressures and sublimation enthalpies. The values of the sublimation pressures were subsequently used to successfully model different multiphasic equilibria, as solid-supercritical fluids and solid-solvent-supercritical fluids with the Peng-Robinson equation of state (without considering the sublimation pressure as an adjustable parameter). On the other hand, the sublimation pressures were also used to calculate solid sublimation properties and acetaminophen solvation properties in some solvents. Also, solubility data solid-supercritical fluids from 62 pharmaceuticals were fitted with different semiempirical equations (Chrastil, Kumar-Johnston and Bartle models) in order to present the values of solvation enthalpies in sc-CO 2 and vaporization enthalpies for these compounds. All of these results highlight that semiempirical models can be used for any other purpose as well as modeling (solid + supercritical fluids) equilibria.

  4. Infectious Progression of Canine Distemper Virus from Circulating Cerebrospinal Fluid into the Central Nervous System.

    Science.gov (United States)

    Takenaka, Akiko; Sato, Hiroki; Ikeda, Fusako; Yoneda, Misako; Kai, Chieko

    2016-10-15

    many respects, the pathogenesis of CDV infection in animals resembles that of measles virus infection in humans. We successfully generated a recombinant CDV containing the H and P genes from a mouse-adapted neurovirulent strain and expressing EGFP. The recombinant CDV exhibited severe neurovirulence with high mortality, comparable to the parental mouse-adapted strain. The mouse-infectious model could become a useful tool for analyzing CDV infection of the central nervous system subsequent to passing through the blood-cerebrospinal fluid barrier and infectious progression in the target cells in acute disease. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  5. On/off multi-poppet valve for switching manifold in discrete fluid power force system PTO in wave energy converters

    DEFF Research Database (Denmark)

    Hansen, Anders Hedegaard; Pedersen, Henrik C.; Andersen, Torben Ole

    2014-01-01

    Fluid power systems are the leading technology for power take off systems in ocean wave energy converters. However, fluid power systems often suffer from poor efficiency, especially in part loads. This degrades the PTO system efficiency and therefore lowers the energy production. To overcome......, the choice of pilot valve, structural mechanical issues and modelling and simulation of various valve configurations. Hence, a mechatronic design process is utilised to choose the best valve configuration....

  6. Selection of working fluids for a novel low-temperature geothermally-powered ORC based cogeneration system

    International Nuclear Information System (INIS)

    Guo, T.; Wang, H.X.; Zhang, S.J.

    2011-01-01

    Highlights: → Performances of a novel cogeneration system using low-temperature geothermal sources under disturbance conditions were investigated. → It aimed at identifying appropriate fluids yielding high PPR and QQR values. → Fluids group presenting higher normal boiling point values showed averagely 7.7% higher PPR with a larger variation than QQR values under disturbance conditions. → Smaller T P value, higher η t value, higher geothermal source parameters and lower heating supply parameters led to higher PPR values but lower QQR values. -- Abstract: A novel cogeneration system driven by low-temperature geothermal sources was investigated in this study. This system consists of a low-temperature geothermally-powered organic Rankine cycle (ORC) subsystem, an intermediate heat exchanger and a commercial R134a-based heat pump subsystem. The main purpose is to identify appropriate fluids which may yield high PPR (the ratio of power produced by the power generation subsystem to power consumed by the heat pump subsystem) value and QQR (the ratio of heat supplied to the user to heat produced by the geothermal source) value. Performances of the novel cogeneration system under disturbance conditions have also been studied. Results indicate that fluids group presenting higher normal boiling point values shows averagely 7.7% higher PPR values and R236ea and R245ca outstand among the group. ΔT P (pinch temperature difference in heat exchangers) and η t (turbine efficiency) values play more important roles on the variation of PPR values. QQR values change slightly with various ΔT P , η t and η rp (refrigerant pump efficiency) values while the variation range is larger under various geothermal source and heating supply parameters. Smaller ΔT P value, higher η t value, higher geothermal source parameters and lower heating supply parameters lead to higher PPR values but lower QQR values.

  7. The multiphase flow system used in exploiting depleted reservoirs: water-based Micro-bubble drilling fluid

    International Nuclear Information System (INIS)

    Zheng Lihui; He Xiaoqing; Wang Xiangchun; Fu Lixia

    2009-01-01

    Water-based micro-bubble drilling fluid, which is used to exploit depleted reservoirs, is a complicated multiphase flow system that is composed of gas, water, oil, polymer, surfactants and solids. The gas phase is separate from bulk water by two layers and three membranes. They are 'surface tension reducing membrane', 'high viscosity layer', 'high viscosity fixing membrane', 'compatibility enhancing membrane' and 'concentration transition layer of liner high polymer (LHP) and surfactants' from every gas phase centre to the bulk water. 'Surface tension reducing membrane', 'high viscosity layer' and 'high viscosity fixing membrane' bond closely to pack air forming 'air-bag', 'compatibility enhancing membrane' and 'concentration transition layer of LHP and surfactants' absorb outside 'air-bag' to form 'incompact zone'. From another point of view, 'air-bag' and 'incompact zone' compose micro-bubble. Dynamic changes of 'incompact zone' enable micro-bubble to exist lonely or aggregate together, and lead the whole fluid, which can wet both hydrophilic and hydrophobic surface, to possess very high viscosity at an extremely low shear rate but to possess good fluidity at a higher shear rate. When the water-based micro-bubble drilling fluid encounters leakage zones, it will automatically regulate the sizes and shapes of the bubbles according to the slot width of fracture, the height of cavern as well as the aperture of openings, or seal them by making use of high viscosity of the system at a very low shear rate. Measurements of the rheological parameters indicate that water-based micro-bubble drilling fluid has very high plastic viscosity, yield point, initial gel, final gel and high ratio of yield point and plastic viscosity. All of these properties make the multiphase flow system meet the requirements of petroleum drilling industry. Research on interface between gas and bulk water of this multiphase flow system can provide us with information of synthesizing effective

  8. Model Predictive Control of a Wave Energy Converter with Discrete Fluid Power Power Take-Off System

    DEFF Research Database (Denmark)

    Hansen, Anders Hedegaard; Asmussen, Magnus Færing; Bech, Michael Møller

    2018-01-01

    Wave power extraction algorithms for wave energy converters are normally designed without taking system losses into account leading to suboptimal power extraction. In the current work, a model predictive power extraction algorithm is designed for a discretized power take of system. It is shown how...... the quantized nature of a discrete fluid power system may be included in a new model predictive control algorithm leading to a significant increase in the harvested power. A detailed investigation of the influence of the prediction horizon and the time step is reported. Furthermore, it is shown how...

  9. Development of a consensus standard for verification and validation of nuclear system thermal-fluids software

    International Nuclear Information System (INIS)

    Harvego, Edwin A.; Schultz, Richard R.; Crane, Ryan L.

    2011-01-01

    With the resurgence of nuclear power and increased interest in advanced nuclear reactors as an option to supply abundant energy without the associated greenhouse gas emissions of the more conventional fossil fuel energy sources, there is a need to establish internationally recognized standards for the verification and validation (V and V) of software used to calculate the thermal–hydraulic behavior of advanced reactor designs for both normal operation and hypothetical accident conditions. To address this need, ASME (American Society of Mechanical Engineers) Standards and Certification has established the V and V 30 Committee, under the jurisdiction of the V and V Standards Committee, to develop a consensus standard for verification and validation of software used for design and analysis of advanced reactor systems. The initial focus of this committee will be on the V and V of system analysis and computational fluid dynamics (CFD) software for nuclear applications. To limit the scope of the effort, the committee will further limit its focus to software to be used in the licensing of High-Temperature Gas-Cooled Reactors. Although software verification will be an important and necessary part of the standard, much of the initial effort of the committee will be focused on the validation of existing software and new models that could be used in the licensing process. In this framework, the Standard should conform to Nuclear Regulatory Commission (NRC) and other regulatory practices, procedures and methods for licensing of nuclear power plants as embodied in the United States (U.S.) Code of Federal Regulations and other pertinent documents such as Regulatory Guide 1.203, “Transient and Accident Analysis Methods” and NUREG-0800, “NRC Standard Review Plan”. In addition, the Standard should be consistent with applicable sections of ASME NQA-1-2008 “Quality Assurance Requirements for Nuclear Facility Applications (QA)”. This paper describes the general

  10. Seismic and structural characterization of the fluid bypass system using 3D and partial stack seismic from passive margin: inside the plumbing system.

    Science.gov (United States)

    Iacopini, David; Maestrelli, Daniele; Jihad, Ali; Bond, Clare; Bonini, Marco

    2017-04-01

    In recent years enormous attention has been paid to the understanding of the process and mechanism controlling the gas seepage and more generally the fluid expulsion affecting the earth system from onshore to offshore environment. This is because of their demonstrated impact to our environment, climate change and during subsea drilling operation. Several example from active and paleo system has been so far characterized and proposed using subsurface exploration, geophysical and geochemical monitoring technology approaches with the aims to explore what trigger and drive the overpressure necessary maintain the fluid/gas/material expulsion and what are the structure that act as a gateway for gaseous fluid and unconsolidated rock. In this contribution we explore a series of fluid escape structure (ranging from seepage pipes to large blowout pipes structure of km length) using 3D and partial stack seismic data from two distinctive passive margin from the north sea (Loyal field, West Shetland) and the Equatorial Brazil (Ceara' Basin). We will focuses on the characterization of the plumbing system internal architecture and, for selected example, exploring the AVO response (using partial stack) of the internal fluid/unconsolidated rock. The detailed seismic mapping and seismic attributes analysis of the conduit system helped us to recover some detail from the signal response of the chimney internal structures. We observed: (1) small to medium seeps and pipes following structural or sedimentary discontinuities (2) large pipes (probably incipient mud volcanoes) and blowup structures propagating upward irrespective of pre-existing fault by hydraulic fracturing and assisted by the buoyancy of a fluidised and mobilised mud-hydrocarbon mixture. The reflector termination observed inside the main conduits, the distribution of stacked bright reflectors and the AVO analysis suggests an evolution of mechanisms (involving mixture of gas, fluid and probably mud) during pipe birth and

  11. Supercritical CO2 fluid radiochromatography system used to purify [11C]toluene for PET

    International Nuclear Information System (INIS)

    Muller, Ryan D.; Ferrieri, Richard A.; Gerasimov, Madina; Garza, Victor

    2002-01-01

    Abuse of inhalants in today's society has become such a widespread problem among today's adolescents that in many parts of the world their use exceeds that of many other illicit drugs or alcohol. Even so, little is known how such inhalants affect brain function to an extent that can lead to an abuse liability. While methodologies exist for radiolabeling certain inhalants of interest with short-lived positron emitting radioisotopes that would allow their investigation in human subjects using positron emission tomography (PET), the purification methodologies necessary to separate these volatile substances from the organic starting materials have not been developed. We've adapted supercritical fluid technology to this specific PET application by building a preparative-scale supercritical CO 2 fluid radiochromatograph, and applied it to the purification of [ 11 C]toluene. We've demonstrated that [ 11 C]toluene can be separated from the starting materials using a conventional C 18 HPLC column and pure supercritical CO 2 fluid as the mobile phase operating at 2000 psi and 40 deg. C. We've also shown that the purified radiotracer can be quantitatively captured on Tenax GR, a solid support material, as it exits the supercritical fluid stream, thus allowing for later desorption into a 1.5% cyclodextrin solution that is suitable for human injection, or into a breathing tube for direct inhalation

  12. Cyclosporin A levels in suction-blister fluid of patients with psoriasis treated systemically

    NARCIS (Netherlands)

    Meinardi, M. M.; van Eendenburg, J. P.; Oosting, J.; van Boxtel, C. J.; de Rie, M. A.; Bos, J. D.

    1990-01-01

    Oral cyclosporin A (CyA) is highly effective in the treatment of psoriasis. The long-term use is limited by dose-dependent side-effects, and the local concentration of CyA is a determining factor in treatment. The concentration of CyA in suction-blister fluid (SBF) and in whole blood was assessed

  13. Derivation of transient relativistic fluid dynamics from the Boltzmann equation for a multi-component system

    Energy Technology Data Exchange (ETDEWEB)

    Denicol, G.S. [Department of Physics, McGill University, 3600 University Street, Montreal, Quebec, H3A2T8 (Canada); Institut für Theoretische Physik, Johann Wolfgang Goethe-Universität, Max-von-Laue-Str. 1, D-60438 Frankfurt am Main (Germany); Niemi, H. [Department of Physics, P.O. Box 35, FI-40014 University of Jyväskylä (Finland)

    2013-05-02

    We derive the non-equilibrium single-particle momentum distribution function of a hadron resonance gas. We then study the effects that this newly derived expression can have in the freeze-out description of fluid-dynamical models of heavy ion collisions and compare it with the method traditionally employed, the 14-moment approximation.

  14. A novel enzyme-based acidizing system: Matrix acidizing and drilling fluid damage removal

    Energy Technology Data Exchange (ETDEWEB)

    Harris, R.E.; McKay, D.M. [Cleansorb Limited, Surrey (United Kingdom); Moses, V. [King`s College, London (United Kingdom)

    1995-12-31

    A novel acidizing process is used to increase the permeability of carbonate rock cores in the laboratory and to remove drilling fluid damage from cores and wafers. Field results show the benefits of the technology as applied both to injector and producer wells.

  15. Magnetic Particles as Multifunctional Transport Carriers and Fluid Drivers in Micro Systems

    NARCIS (Netherlands)

    Derks, R.J.S.; Frijns, A.J.H.; Prins, M.W.J.; Dietzel, A.H.

    2008-01-01

    Magnetic actuation principles using superparamagnetic particles suspended in a fluid are studied in this paper. Two experimental setups for different magnetic field settings are designed and fabricated. On the basis of optical velocity measurements, the induced behavior of single and ordered chains

  16. "Heads I Win, Tails You Lose": Anti-Black Racism as Fluid, Relentless, Individual and Systemic

    Science.gov (United States)

    Gillborn, David

    2018-01-01

    Derrick Bell's thesis, that racism is a permanent feature of society, is frequently misrepresented by detractors as signaling a view of racism as monolithic--bold, obvious, and unchanging. This paper argues that critical race theory [CRT] reveals a very different understanding of racism as relentless, yet fluid, and quick to morph depending on…

  17. Seismicity within the Irpinia Fault System As Monitored By Isnet (Irpinia Seismic Network) and Its Possible Relation with Fluid Storage

    Science.gov (United States)

    Festa, G.; Zollo, A.; Amoroso, O.; Ascione, A.; Colombelli, S.; Elia, L.; Emolo, A.; Martino, C.; Mazzoli, S.; Orefice, A.; Russo, G.

    2014-12-01

    ISNet (http://isnet.fisica.unina.it) is deployed in Southern Apennines along the active fault system responsible for the 1980, M 6.9 Irpinia earthquake. ISNet consists of 32 seismic stations equipped with both strong motion and velocimetric instruments (either broadband or short-period), with the aim of capture a broad set of seismic signals, from ambient noise to strong motion. Real time and near real time procedures run at ISNet with the goal of monitoring the seismicity, check possible space-time anomalies, detect seismic sequences and launch an earthquake early warning in the case of potential significant ground shaking in the area. To understand the role of fluids on the seismicity of the area, we investigated velocity and attenuation models. The former is built from accurate cross-correlation picking and S wave detection based onto polarization analysis. Joint inversion of both P and S arrival times is then based on a linearized multi-scale tomographic approach. Attenuation is instead obtained from inversion of displacement spectra, deconvolving for the source effect. High VP/VS and QS/QP >1 were found within a ~15 km wide rock volume where intense microseismicity is located. This indicates that concentration of seismicity is possibly controlled by high pore fluid pressure. This earthquake reservoir may come from a positive feedback between the seismic pumping that controls the fluid transmission through the fractured damage zone and the low permeability of cross fault barrier, increasing the fluid pore pressure within the fault bounded block. In this picture, sequences mostly occur at the base of this fluid rich layer. They show an anomalous pattern in the earthquake occurrence per magnitude classes; main events evolve with a complex source kinematics, as obtained from backprojection of apparent source time functions, indicating possible directivity effects. In this area sequences might be the key for understanding the transition between the deep

  18. Bioelectrical impedance spectroscopy as a fluid management system in heart failure

    International Nuclear Information System (INIS)

    Weyer, Sören; Wartzek, Tobias; Leicht, Lennart; Leonhardt, Steffen; Zink, Matthias Daniel; Mischke, Karl; Vollmer, Thomas

    2014-01-01

    Episodes of hospitalization for heart failure patients are frequent and are often accompanied by fluid accumulations. The change of the body impedance, measured by bioimpendace spectroscopy, is an indicator of the water content. The hypothesis was that it is possible to detect edema from the impedance data. First, a finite integration technique was applied to test the feasibility and allowed a theoretical analysis of current flows through the body. Based on the results of the simulations, a clinical study was designed and conducted. The segmental impedances of 25 patients suffering from heart failure were monitored over their recompensation process. The mean age of the patients was 73.8 and their mean body mass index was 28.6. From these raw data the model parameters from the Cole model were deduced by an automatic fitting algorithm. These model data were used to classify the edema status of the patient. The baseline values of the regression lines of the extra- and intracellular resistance from the transthoracic measurement and the baseline value of the regression line of the extracellular resistance from the foot-to-foot measurement were identified as important parameters for the detection of peripheral edema. The rate of change of the imaginary impedance at the characteristic frequency and the mean intracellular resistance from the foot-to-foot measurement were identified as important parameters for the detection of pulmonary edema. To classify the data, two decision trees were considered: One should detect pulmonary edema (n pulmonary = 13, n none = 12) and the other peripheral edema (n peripheral = 12, n none = 13). Peripheral edema could be detected with a sensitivity of 100% and a specificity of 90%. The detection of pulmonary edema showed a sensitivity of 92.31% and a specificity of 100%. The leave-one-out cross-validation-error for the peripheral edema detection was 12% and 8% for the detection of pulmonary edema. This enables the application of BIS as an

  19. Compressible Fluid Suspension Performance Testing

    National Research Council Canada - National Science Library

    Hoogterp, Francis

    2003-01-01

    ... compressible fluid suspension system that was designed and installed on the vehicle by DTI. The purpose of the tests was to evaluate the possible performance benefits of the compressible fluid suspension system...

  20. Numerical Study on CO2-Brine-Rock Interaction of Enhanced Geothermal Systems with CO2 as Heat Transmission Fluid

    Directory of Open Access Journals (Sweden)

    Wan Yuyu

    2016-01-01

    Full Text Available Enhanced Geothermal Systems (EGS with CO2 instead of water as heat transmission fluid is an attractive concept for both geothermal resources development and CO2 geological sequestration. Previous studies show that CO2 has lots of favorable properties as heat transmission fluid and also can offer geologic storage of CO2 as an ancillary benefit. However, after CO2 injection into geological formations, chemical reaction between brine and rock can change chemical characteristics of saline and properties of rock such as porosity and permeability. Is this advantage or disadvantage for EGS operating? To answer this question, we have performed chemically reactive transport modeling to investigate fluid-rock interactions and CO2 mineral carbonation of Enhanced Geothermal Systems (EGS site at Desert Peak (Nevada operated with CO2. The simulation results show that (1 injection CO2 can create a core zone fulfilled with CO2 as main working domain for EGS, and (2 CO2 storage can induced self-enhancing alteration of EGS.

  1. A family of solutions to the Einstein-Maxwell system of equations describing relativistic charged fluid spheres

    Science.gov (United States)

    Komathiraj, K.; Sharma, Ranjan

    2018-05-01

    In this paper, we present a formalism to generate a family of interior solutions to the Einstein-Maxwell system of equations for a spherically symmetric relativistic charged fluid sphere matched to the exterior Reissner-Nordström space-time. By reducing the Einstein-Maxwell system to a recurrence relation with variable rational coefficients, we show that it is possible to obtain closed-form solutions for a specific range of model parameters. A large class of solutions obtained previously are shown to be contained in our general class of solutions. We also analyse the physical viability of our new class of solutions.

  2. Fluid mixing and the deep biosphere of a fossil Lost City-type hydrothermal system at the Iberia Margin.

    Science.gov (United States)

    Klein, Frieder; Humphris, Susan E; Guo, Weifu; Schubotz, Florence; Schwarzenbach, Esther M; Orsi, William D

    2015-09-29

    Subseafloor mixing of reduced hydrothermal fluids with seawater is believed to provide the energy and substrates needed to support deep chemolithoautotrophic life in the hydrated oceanic mantle (i.e., serpentinite). However, geosphere-biosphere interactions in serpentinite-hosted subseafloor mixing zones remain poorly constrained. Here we examine fossil microbial communities and fluid mixing processes in the subseafloor of a Cretaceous Lost City-type hydrothermal system at the magma-poor passive Iberia Margin (Ocean Drilling Program Leg 149, Hole 897D). Brucite-calcite mineral assemblages precipitated from mixed fluids ca. 65 m below the Cretaceous paleo-seafloor at temperatures of 31.7 ± 4.3 °C within steep chemical gradients between weathered, carbonate-rich serpentinite breccia and serpentinite. Mixing of oxidized seawater and strongly reducing hydrothermal fluid at moderate temperatures created conditions capable of supporting microbial activity. Dense microbial colonies are fossilized in brucite-calcite veins that are strongly enriched in organic carbon (up to 0.5 wt.% of the total carbon) but depleted in (13)C (δ(13)C(TOC) = -19.4‰). We detected a combination of bacterial diether lipid biomarkers, archaeol, and archaeal tetraethers analogous to those found in carbonate chimneys at the active Lost City hydrothermal field. The exposure of mantle rocks to seawater during the breakup of Pangaea fueled chemolithoautotrophic microbial communities at the Iberia Margin, possibly before the onset of seafloor spreading. Lost City-type serpentinization systems have been discovered at midocean ridges, in forearc settings of subduction zones, and at continental margins. It appears that, wherever they occur, they can support microbial life, even in deep subseafloor environments.

  3. Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid.

    Science.gov (United States)

    Ju, Yo-El S; Finn, Mary Beth; Sutphen, Courtney L; Herries, Elizabeth M; Jerome, Gina M; Ladenson, Jack H; Crimmins, Daniel L; Fagan, Anne M; Holtzman, David M

    2016-07-01

    We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-β-40 was decreased in the OSA group. Other neuronally derived proteins, but not total protein, were also decreased in the OSA group, suggesting that OSA may affect the interaction between interstitial and cerebrospinal fluid. Ann Neurol 2016;80:154-159. © 2016 American Neurological Association.

  4. Experimental study of high-performance cooling system pipeline diameter and working fluid amount

    Science.gov (United States)

    Nemec, Patrik; Malcho, Milan; Hrabovsky, Peter; Papučík, Štefan

    2016-03-01

    This work deals with heat transfer resulting from the operation of power electronic components. Heat is removed from the mounting plate, which is the evaporator of the loop thermosyphon to the condenser and by natural convection is transferred to ambient. This work includes proposal of cooling device - loop thermosyphon, with its construct and follow optimization of cooling effect. Optimization proceeds by selecting the quantity of working fluid and selection of diameters vapour line and liquid line of loop thermosyphon.

  5. Two-phase cooling fluids; Les fluides frigoporteurs diphasiques

    Energy Technology Data Exchange (ETDEWEB)

    Lallemand, A. [Institut National des Sciences Appliquees (INSA), 69 - Lyon (France)

    1997-12-31

    In the framework of the diminution of heat transfer fluid consumption, the concept of indirect refrigerating circuits, using cooling intermediate fluids, is reviewed and the fluids that are currently used in these systems are described. Two-phase cooling fluids advantages over single-phase fluids are presented with their thermophysical characteristics: solid fraction, two-phase mixture enthalpy, thermal and rheological properties, determination of heat and mass transfer characteristics, and cold storage through ice slurry

  6. An Integrated Model of the Cardiovascular and Central Nervous Systems for Analysis of Microgravity Induced Fluid Redistribution

    Science.gov (United States)

    Price, R.; Gady, S.; Heinemann, K.; Nelson, E. S.; Mulugeta, L.; Ethier, C. R.; Samuels, B. C.; Feola, A.; Vera, J.; Myers, J. G.

    2015-01-01

    A recognized side effect of prolonged microgravity exposure is visual impairment and intracranial pressure (VIIP) syndrome. The medical understanding of this phenomenon is at present preliminary, although it is hypothesized that the headward shift of bodily fluids in microgravity may be a contributor. Computational models can be used to provide insight into the origins of VIIP. In order to further investigate this phenomenon, NASAs Digital Astronaut Project (DAP) is developing an integrated computational model of the human body which is divided into the eye, the cerebrovascular system, and the cardiovascular system. This presentation will focus on the development and testing of the computational model of an integrated model of the cardiovascular system (CVS) and central nervous system (CNS) that simulates the behavior of pressures, volumes, and flows within these two physiological systems.

  7. A combined geochemical and isotopic study of the fluids discharged from the Montecatini thermal system (NW Tuscany, Italy)

    International Nuclear Information System (INIS)

    Capecchiacci, F.; Tassi, F.; Vaselli, O.; Bicocchi, G.; Cabassi, J.; Giannini, L.; Nisi, B.; Chiocciora, G.

    2015-01-01

    Highlights: • Water chemistry of the Montecatini thermal system (MTS) indicates a Na–Cl composition. • Dissolved gases are dominated by a CO 2 -rich gas phase. • MTS is fed by meteoric waters with a relatively long (>50 years) circulation. • Geothermometric estimations suggest that the fluid reservoir is at T ⩾ 80–90 °C. • A new conceptual model of fluid circulation was proposed for MTS. - Abstract: The thermo-mineral fluids discharges of Montecatini Terme (Northern Apennines, Tuscany, Italy) have been exploited since the Roman times and despite the fact that this thermal complex is one of the biggest in Europe, the most recent geochemical investigations were published almost 40 years ago. To fill this gap, in this paper a detailed geochemical and isotopic investigation on the main thermal springs and wells from the Montecatini thermal system (MTS) is presented. The chemical and isotopic features of the Montecatini waters suggested that they are mainly controlled by water–rock interaction processes between meteoric water, permeating at depth from the surrounding reliefs (up to 800 m a.s.l.), and the Triassic evaporites (Burano Formation) belonging to the Tuscan sedimentary series. The local stratigraphic and tectonic framework favors an efficient recharge of the hydrothermal reservoir by the meteoric precipitation from a large catchment area and this aspect plays a fundamental role for the longevity of the Montecatini thermal spas, notwithstanding the huge amount of thermal water exploited. The 3 H values indicated that the thermal waters are likely related to a relatively long (>50 years) fluid circulation pattern. Approaching the surface, thermal and saline waters mix with cold and low TDS (Total Dissolved Solids) waters hosted in short, shallow aquifer(s), whose chemistry is dictated by the interaction of rain waters with silico-clastic rocks of low solubility. Geothermometric estimations in the F − –SO 4 2− –HCO 3 − system suggested

  8. A heterogeneous system based on GPU and multi-core CPU for real-time fluid and rigid body simulation

    Science.gov (United States)

    da Silva Junior, José Ricardo; Gonzalez Clua, Esteban W.; Montenegro, Anselmo; Lage, Marcos; Dreux, Marcelo de Andrade; Joselli, Mark; Pagliosa, Paulo A.; Kuryla, Christine Lucille

    2012-03-01

    Computational fluid dynamics in simulation has become an important field not only for physics and engineering areas but also for simulation, computer graphics, virtual reality and even video game development. Many efficient models have been developed over the years, but when many contact interactions must be processed, most models present difficulties or cannot achieve real-time results when executed. The advent of parallel computing has enabled the development of many strategies for accelerating the simulations. Our work proposes a new system which uses some successful algorithms already proposed, as well as a data structure organisation based on a heterogeneous architecture using CPUs and GPUs, in order to process the simulation of the interaction of fluids and rigid bodies. This successfully results in a two-way interaction between them and their surrounding objects. As far as we know, this is the first work that presents a computational collaborative environment which makes use of two different paradigms of hardware architecture for this specific kind of problem. Since our method achieves real-time results, it is suitable for virtual reality, simulation and video game fluid simulation problems.

  9. Birch Bark Dry Extract by Supercritical Fluid Technology: Extract Characterisation and Use for Stabilisation of Semisolid Systems

    Directory of Open Access Journals (Sweden)

    Markus Armbruster

    2017-03-01

    Full Text Available Triterpene compounds like betulin, betulinic acid, erythrodiol, oleanolic acid and lupeol are known for many pharmacological effects. All these substances are found in the outer bark of birch. Apart from its pharmacological effects, birch bark extract can be used to stabilise semisolid systems. Normally, birch bark extract is produced for this purpose by extraction with organic solvents. Employing supercritical fluid technology, our aim was to develop a birch bark dry extract suitable for stabilisation of lipophilic gels with improved properties while avoiding the use of toxic solvents. With supercritical carbon dioxide, three different particle formation methods from supercritical solutions have been tested. First, particle deposition was performed from a supercritical solution in an expansion chamber. Second, the Rapid Expansion of Supercritical Solutions (RESS method was used for particle generation. Third, a modified RESS-procedure, forming the particles directly into the thereby gelated liquid, was developed. All three methods gave yields from 1% to 5.8%, depending on the techniques employed. The triterpene composition of the three extracts was comparable: all three gave more stable oleogels compared to the use of an extract obtained by organic solvent extraction. Characterizing the rheological behaviour of these gels, a faster gelling effect was seen together with a lower concentration of the extract required for the gel formation with the supercritical fluid (SCF-extracts. This confirms the superiority of the supercritical fluid produced extracts with regard to the oleogel forming properties.

  10. Composition and source of salinity of ore-bearing fluids in Cu-Au systems of the Carajás Mineral Province, Brazil

    Science.gov (United States)

    Xavier, Roberto; Rusk, Brian; Emsbo, Poul; Monteiro, Lena

    2009-01-01

    The composition and Cl/Br – NaCl ratios of highly saline aqueous inclusions from large tonnage (> 100 t) IOCG deposits (Sossego, Alvo 118, and Igarapé Bahia) and a Paleoproterozoic intrusion-related Cu-Au-(Mo-W-Bi-Sn) deposit (Breves; Ca-dominated (5 to 10 times more than in porphyry Cu-Au fluids), and contain percent level concentrations of Na and K. IOCG inclusion fluids, however, contain higher Sr, Ba, Pb, and Zn concentrations, but significantly less Bi, than the intrusion-related Breves inclusion fluids. Cu is consistently below detection limits in brine inclusions from the IOCG and intrusion-related systems and Fe was not detected in the latter. Cl/Br and Na/Cl ratios of the IOCG inclusion fluids range from entirely evaporative brines (bittern fluids; e.g. Igarapé Bahia and Alvo 118) to values that indicate mixing with magma-derived brines. Cl/Br and Na/Cl ratios of the Breves inclusion fluids strongly suggest the involvement of magmatic brines, but that possibly also incorporated bittern fluids. Collectively, these data demonstrate that residual evaporative and magmatic brines were important components of the fluid regime involved in the formation of Cu-Au systems in the Carajás Mineral Province.

  11. Coupling fast fluid dynamics and multizone airflow models in Modelica Buildings library to simulate the dynamics of HVAC systems

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Wei [Univ. of Miami, FL (United States). Dept. of Civil, Architectural and Environmental Engineering; Sevilla, Thomas Alonso [Univ. of Miami, FL (United States). Dept. of Civil, Architectural and Environmental Engineering; Zuo, Wangda [Univ. of Miami, FL (United States). Dept. of Civil, Architectural and Environmental Engineering; Sohn, Michael D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Energy Analysis and Environmental Impacts Div.

    2017-06-08

    Historically, multizone models are widely used in building airflow and energy performance simulations due to their fast computing speed. However, multizone models assume that the air in a room is well mixed, consequently limiting their application. In specific rooms where this assumption fails, the use of computational fluid dynamics (CFD) models may be an alternative option. Previous research has mainly focused on coupling CFD models and multizone models to study airflow in large spaces. While significant, most of these analyses did not consider the coupled simulation of the building airflow with the building's Heating, Ventilation, and Air-Conditioning (HVAC) systems. This paper tries to fill the gap by integrating the models for HVAC systems with coupled multizone and CFD simulations for airflows, using the Modelica simul ation platform. To improve the computational efficiency, we incorporated a simplified CFD model named fast fluid dynamics (FFD). We first introduce the data synchronization strategy and implementation in Modelica. Then, we verify the implementation using two case studies involving an isothermal and a non-isothermal flow by comparing model simulations to experiment data. Afterward, we study another three cases that are deemed more realistic. This is done by attaching a variable air volume (VAV) terminal box and a VAV system to previous flows to assess the capability of the models in studying the dynamic control of HVAC systems. Finally, we discuss further research needs on the coupled simulation using the models.

  12. The submarine hydrothermal system of Panarea (Southern Italy: biogeochemical processes at the thermal fluids - sea bottom interface

    Directory of Open Access Journals (Sweden)

    T. Maugeri

    2006-06-01

    Full Text Available Among the submarine hydrothermal systems located offshore the volcanic archipelago of the Aeolian Islands (Southern Italy, the most active is located off the coasts of Panarea island. Thermal waters, gases and sulfur deposits coexist at the sea bottom where hydrothermal fluids are released from both shallow and deep vents. The chemical and isotopic composition of the fluid phase shows the presence of a significant magmatic component and the physico-chemical conditions of the geothermal reservoir allow the release of reduced chemical species that are microbially mediated towards the production of organic carbon as a form of biochemical energy. Microorganisms inhabiting this environment possess nutritional requirements and overall metabolic pathways ideally suited to such ecosystem that represents a clear example of the close connection between geosphere and biosphere. Microscopic examination of the white mat attached to rock surfaces showed the presence of Thiothrix-like filamentous bacteria. Moderately thermophilic heterotrophic isolates were identified as strains of the genus Bacillus. Although the hydrothermal system of Panarea has to be considered a “shallow” system, it shows many characteristics that make it similar to the “deep” oceanic systems, giving a unique opportunity for improving our knowledge on such an unexplored world by working at this easily accessible site.

  13. Boiling of multicomponent working fluids used in refrigeration and cryogenic systems

    Science.gov (United States)

    Mogorychny, V. I.; Dolzhikov, A. S.

    2017-11-01

    Working fluids based on mixtures are widely used in cryogenic and refrigeration engineering. One of the main elements of low-temperature units is a recuperative heat exchanger where the return flow cools the direct (cold regeneration is carrying out) resulting in continuous boiling and condensation of the multicomponent working fluid in the channels. The temperature difference between the inlet and outlet of the heat exchanger can be more than 100K, which leads to a strong change in thermophysical properties along its length. In addition, the fraction of the liquid and vapor phases in the flow varies very much, which affects the observed flow regimes in the heat exchanger channels. At the moment there are not so many experimental data and analytical correlations that would allow to estimate the heat transfer coefficient during the flow of a two-phase mixture flow at low temperatures. The work is devoted to the study of the boiling process of multicomponent working fluids used in refrigeration and cryogenic engineering. The description of the method of determination of heat transfer coefficient during boiling of mixtures in horizontal heated channel is given as well as the design of the experimental stand allowing to make such measurements. This stand is designed on the basis of a refrigeration unit operating on the Joule-Thomson throttle cycle and makes it possible to measure the heat transfer coefficient with a good accuracy. Also, the calculated values of the heat transfer coefficient, obtained with the use of various correlations, are compared with the existing experimental data. Knowing of the heat transfer coefficient will be very useful in the design of heat exchangers for low-temperature units operating on a mixture refrigerant.

  14. Performance of a Polymer Flood with Shear-Thinning Fluid in Heterogeneous Layered Systems with Crossflow

    Directory of Open Access Journals (Sweden)

    Kun Sang Lee

    2011-08-01

    Full Text Available Assessment of the potential of a polymer flood for mobility control requires an accurate model on the viscosities of displacement fluids involved in the process. Because most polymers used in EOR exhibit shear-thinning behavior, the effective viscosity of a polymer solution is a highly nonlinear function of shear rate. A reservoir simulator including the model for the shear-rate dependence of viscosity was used to investigate shear-thinning effects of polymer solution on the performance of the layered reservoir in a five-spot pattern operating under polymer flood followed by waterflood. The model can be used as a quantitative tool to evaluate the comparative studies of different polymer flooding scenarios with respect to shear-rate dependence of fluids’ viscosities. Results of cumulative oil recovery and water-oil ratio are presented for parameters of shear-rate dependencies, permeability heterogeneity, and crossflow. The results of this work have proven the importance of taking non-Newtonian behavior of polymer solution into account for the successful evaluation of polymer flood processes. Horizontal and vertical permeabilities of each layer are shown to impact the predicted performance substantially. In reservoirs with a severe permeability contrast between horizontal layers, decrease in oil recovery and sudden increase in WOR are obtained by the low sweep efficiency and early water breakthrough through highly permeable layer, especially for shear-thinning fluids. An increase in the degree of crossflow resulting from sufficient vertical permeability is responsible for the enhanced sweep of the low permeability layers, which results in increased oil recovery. It was observed that a thinning fluid coefficient would increase injectivity significantly from simulations with various injection rates. A thorough understanding of polymer rheology in the reservoir and accurate numerical modeling are of fundamental importance for the exact estimation

  15. Coupling a system code with computational fluid dynamics for the simulation of complex coolant reactivity effects

    International Nuclear Information System (INIS)

    Bertolotto, D.

    2011-11-01

    The current doctoral research is focused on the development and validation of a coupled computational tool, to combine the advantages of computational fluid dynamics (CFD) in analyzing complex flow fields and of state-of-the-art system codes employed for nuclear power plant (NPP) simulations. Such a tool can considerably enhance the analysis of NPP transient behavior, e.g. in the case of pressurized water reactor (PWR) accident scenarios such as Main Steam Line Break (MSLB) and boron dilution, in which strong coolant flow asymmetries and multi-dimensional mixing effects strongly influence the reactivity of the reactor core, as described in Chap. 1. To start with, a literature review on code coupling is presented in Chap. 2, together with the corresponding ongoing projects in the international community. Special reference is made to the framework in which this research has been carried out, i.e. the Paul Scherrer Institute's (PSI) project STARS (Steady-state and Transient Analysis Research for the Swiss reactors). In particular, the codes chosen for the coupling, i.e. the CFD code ANSYS CFX V11.0 and the system code US-NRC TRACE V5.0, are part of the STARS codes system. Their main features are also described in Chap. 2. The development of the coupled tool, named CFX/TRACE from the names of the two constitutive codes, has proven to be a complex and broad-based task, and therefore constraints had to be put on the target requirements, while keeping in mind a certain modularity to allow future extensions to be made with minimal efforts. After careful consideration, the coupling was defined to be on-line, parallel and with non-overlapping domains connected by an interface, which was developed through the Parallel Virtual Machines (PVM) software, as described in Chap. 3. Moreover, two numerical coupling schemes were implemented and tested: a sequential explicit scheme and a sequential semi-implicit scheme. Finally, it was decided that the coupling would be single

  16. Mechanotransductive Regulation of Gap-Junction Activity Between MLO-Y4 Osteocyte-Like and MC3T3-E1 Osteoblast-Like Cells in Three-Dimensional Co-Culture.

    Science.gov (United States)

    Juran, C. M.; Blaber, E. A.; Almeida, E. A. C.

    2016-01-01

    Cell and animal studies conducted onboard the International Space Station and formerly on Shuttle flights have provided groundbreaking data illuminating the deleterious biological response of bone to mechanical unloading. However the intercellular communicative mechanisms associated with the regulation of bone synthesis and bone resorption cells are still largely unknown. Connexin-43 (CX43), a gap junction protein, is hypothesized to play a significant role in osteoblast and osteocyte signaling. The purpose of this investigation was to evaluate within a novel three-dimensional microenvironment how the osteocyte-osteoblast gap-junction expression changes when cultures are exposed to exaggerated mechanical load. MLO-Y4 osteocyte-like cells were cultured on a 3D-Biotek polystyrene insert and placed in direct contact with an MC3T3-E1 pre-osteoblast co-cultured monolayer and exposed to 48 h of mechanical stimulation (pulsatile fluid flow (PFF) or monolayer cyclic stretch (MCS)) then evaluated for viability, proliferation, metabolism, and CX43 expression. Mono-cultured MLO-Y4 and MC3T3-E1 control experiments were conducted under PFF and MCS stimulation to observe how strain application stimuli (PFF cell membrane shear or MCS cell focal adhesion/attachment loading) initiates different signaling pathways or downstream regulatory controls. TotalLive cell count, viability and metabolic reduction (Trypan Blue, LIVEDead and Alamar Blue analysis respectively) indicate that mechanical activation of MC3T3-E1 cells inhibits proliferation while maintaining an average 1.04E4 reductioncell metabolic rate, *p0.05 n4. MLO-Y4s in monolayer culture increase in number when exposed to MCS loading but the percent of live cells within the population is low (46.3 total count, *p0.05 n4), these results may indicate an apoptotic signaling cascade. PFF stimulation of the three-dimensional co-cultures elicits a universal increase in CX43 in MLO-Y4 and MC3T3-E1 cells, illustrated by

  17. Estimating the Density of Fluid in a Pipeline System with an Electropump

    DEFF Research Database (Denmark)

    Sadeghi, H.; Poshtan, J.; Poulsen, Niels Kjølstad

    2018-01-01

    to detect the product in the pipeline is to sample the fluid in a laboratory and perform an offline measurement of its physical characteristics. The measurement requires sophisticated laboratory equipment and can be time-consuming and susceptible to human error. In this paper, for performing the online......To transfer petroleum products, a common pipeline is often used to continuously transfer various products in batches. Separating the different products requires detecting the interface between the batches at the storage facilities or pump stations along the pipelines. The conventional technique...

  18. Dynamic response of a system with internal heat sources cooled by a flowing incompressible fluid

    International Nuclear Information System (INIS)

    Georgescu, R.; Dobrescu, C.

    1975-01-01

    The paper investigates the dynamic temperature response of an incompressible fluid which cools a duct with internal heat sources sinusoidally oscillated. The analytical results utilise the Laplace transformation technique. The experimental and calculated results are obtained by transfer function approach. Comparison of the calculated with the experimental data indicates agreement from 6 to 24 percent for the amplitude and up to 30 degree for the phase-shift. All the calculated data are below the experimental ones. The analytical method of transfer function approach presents interest and may be utilized for the initial calculations giving good results for flow rates above 1000 kg per hour

  19. Enhanced Geothermal Systems (EGS) comparing water with CO2 as heattransmission fluids

    Energy Technology Data Exchange (ETDEWEB)

    Pruess, Karsten

    2007-11-01

    This paper summarizes our research to date into operatingEGS with CO2. Our modeling studies indicate that CO2 would achieve morefavorable heat extraction than aqueous fluids. The peculiarthermophysicalproperties of CO2 give rise to unusual features in the dependence ofenergy recovery on thermodynamic conditions and time. Preliminarygeochemical studies suggest that CO2 may avoid unfavorable rock-fluidinteractions that have been encountered in water-basedsystems. To morefully evaluate the potential of EGS with CO2 will require an integratedresearch programme of model development, and laboratory and fieldstudies.

  20. Thermodynamic analysis of an absorption refrigeration system with ionic-liquid/refrigerant mixture as a working fluid

    International Nuclear Information System (INIS)

    Kim, Yoon Jo; Kim, Sarah; Joshi, Yogendra K.; Fedorov, Andrei G.; Kohl, Paul A.

    2012-01-01

    Thermodynamics of an ionic-liquid (IL) based absorption refrigeration system has been numerically analyzed. It provides an alternative to the normally toxic working fluids, such as the ammonia in conventional absorption systems. The use of ILs also eliminates crystallization and metal-compatibility problems of the water/LiBr system. Mixtures of refrigerants and imidazolium-based ILs are theoretically explored as the working fluid pairs in a miniature absorption refrigeration system, so as to utilize waste-heat to power a refrigeration/heat pump system for electronics cooling. A non-random two-liquid (NRTL) model was built and used to predict the solubility of the mixtures. Saturation temperatures at the evaporator and condenser were set at 25 °C and 50 °C, respectively, with the power dissipation of 100 W. Water in combination with [emim][BF 4 ] (1-ethyl-3-methylimidazolium tetrafluoroborate) gave the highest coefficient of performance (COP) around 0.9. The refrigerant/IL compatibility indicated by the circulation ratio, alkyl chain length of the IL, and thermodynamic properties of the refrigerants, such as latent heat of evaporation were proven to be important factors in determining the performance of the absorption system. The negative effect of high viscosity was mitigated by dilution of the IL with the refrigerant and the use of slightly larger microfluidic channel heat exchangers. -- Highlights: ► Mixtures of refrigerant/ionic-liquid are studied for absorption system. ► We carry out comprehensive theoretical thermodynamic analysis. ► The essential factors of refrigerant/IL affecting the performance are identified. ► Water/[emim][BF 4 ] showed the best performance of COP. ► The effects of high viscosity ILs on the system performance are not significant.

  1. Comparison of carbon dioxide emissions with fluid upflow, chemistry, and geologic structures at the Rotorua geothermal system, New Zealand

    International Nuclear Information System (INIS)

    Werner, Cynthia; Cardellini, Carlo

    2006-01-01

    During 2002 and 2003, carbon dioxide fluxes were measured across the Rotorua geothermal system in the Taupo Volcanic Zone (TVZ), New Zealand. The results of a 956-measurement survey and of modeling studies show that CO 2 fluxes could be used to determine the main hot fluid upflow areas in Rotorua, and perhaps in undeveloped geothermal regions. Elevated degassing was observed along inferred fault traces and structures, lending confidence to their existence at depth. Degassing was also observed along lineaments that were consistent with the alignment of basement faulting in the TVZ. Areas where elevated degassing was spatially extensive typically overlapped with known regions of hot ground; however, elevated CO 2 fluxes were also observed in isolated patches of non-thermal ground. The total emission rate calculated from sequential Gaussian simulation modeling of CO 2 fluxes across the geothermal system was 620td -1 from an 8.9-km 2 area. However, because approximately one-third of the geothermal system is known to extend beneath Lake Rotorua, we expect the emissions could be minimally on the order of 1000td -1 . Comparing the emission rate with geochemical analyses of geothermal fluids and estimated upflows suggests that the majority of deep carbon reaches the surface in the form of carbon dioxide gas, and that less than one tenth of the CO 2 emissions is dissolved in, or released from, the fluids at depth. Thus, the geothermal reservoir exerts very little control on deep degassing of CO 2 . Carbon isotopic analyses of soil gases suggest a primarily magmatic source for the origin of the CO 2 . The total Rotorua emission rate is comparable to those from active volcanoes such as at White Island, New Zealand, and, when normalized by geothermal area, is comparable to other volcanic and hydrothermal regions worldwide. (author)

  2. Magmatic fluid inclusions from the Zaldivar Deposits, Northern Chile: The role of early metal-bearing fluids in a Porphyry copper system

    NARCIS (Netherlands)

    drs Campos, E.; Touret, J.L.R.; Nikogosian, I.

    2006-01-01

    The occurrence of a distinct type of multi-solid, highly-saline fluid inclusions, hosted in igneous quartz phenocrysts from the Llamo porphyry, in the Zaldívar porphyry copper deposit of northern Chile is documented. Total homogenization of the multi-solid type inclusions occurs at magmatic

  3. "Magmatic fluid inclusions from the Zaldivar deposit, Northern Chile: The role of Early metal-bearing fluids in a porphyry copper system."

    NARCIS (Netherlands)

    drs Campos, E.; Touret, J.L.R.; Nikogosian, I.

    2006-01-01

    The occurrence of a distinct type of multi-solid, highly-saline fluid inclusions, hosted in igneous quartz phenocrysts from the Llamo porphyry, in the Zaldívar porphyry copper deposit of northern Chile is documented. Total homogenization of the multi-solid type inclusions occurs at magmatic

  4. Fluid Mechanics.

    Science.gov (United States)

    Drazin, Philip

    1987-01-01

    Outlines the contents of Volume II of "Principia" by Sir Isaac Newton. Reviews the contributions of subsequent scientists to the physics of fluid dynamics. Discusses the treatment of fluid mechanics in physics curricula. Highlights a few of the problems of modern research in fluid dynamics. Shows that problems still remain. (CW)

  5. On the equivalence among stress tensors in a gauge-fluid system

    Science.gov (United States)

    Mitra, Arpan Krishna; Banerjee, Rabin; Ghosh, Subir

    2017-12-01

    In this paper, we bring out the subtleties involved in the study of a first-order relativistic field theory with auxiliary field variables playing an essential role. In particular, we discuss the nonisentropic Eulerian (or Hamiltonian) fluid model. Interactions are introduced by coupling the fluid to a dynamical Maxwell (U(1)) gauge field. This dynamical nature of the gauge field is crucial in showing the equivalence, on the physical subspace, of the stress tensor derived from two definitions, i.e. the canonical (Noether) one and the symmetric one. In the conventional equal-time formalism, we have shown that the generators of the space-time transformations obtained from these two definitions agree modulo the Gauss constraint. This equivalence in the physical sector has been achieved only because of the dynamical nature of the gauge fields. Subsequently, we have explicitly demonstrated the validity of the Schwinger condition. A detailed analysis of the model in lightcone formalism has also been done where several interesting features are revealed.

  6. Neutron flux investigation on certain alternative fluids in a hybrid system by using MCNPX Monte Carlo transport code

    Energy Technology Data Exchange (ETDEWEB)

    Guenay, Mehtap [Inoenue Univ., Malatya (Turkey). Physics Dept.

    2014-04-15

    In this study, the molten salt-heavy metal mixtures 93-85 % Li{sub 20}Sn{sub 80} + 5 % SFG-PuO{sub 2} and 2-10 % UO{sub 2}, 93-85 % Li{sub 20}Sn{sub 80} + 5 % SFG-PuO{sub 2} and 2-10 % NpO{sub 2}, 93-85 % Li{sub 20}Sn{sub 80} + 5 % SFG-PuO{sub 2} and 2-10 % UCO were used as fluids. The fluids were used in the liquid first wall, blanket and shield zones of the designed hybrid reactor system. Four centimeter thick 9Cr2WVTa ferritic steel was used as the structural material. In this study, the effect of mixture components on the neutron flux was investigated in a designed fusion-fission hybrid reactor system. The neutron flux was investigated according to the mixture components, radial flux distribution and energy spectrum in the designed system. Three-dimensional analyses were performed using the most recent MCNPX-2.7.0 Monte Carlo radiation transport code and the ENDF/B-VII.0 nuclear data library. (orig.)

  7. Evaluation of the condensation potential of hydrocarbon fluids in the national gas pipeline system; establishing of adequate operational schemes

    International Nuclear Information System (INIS)

    Pineda Gomez, Cesar Augusto; Arenas Mantilla, Oscar Armando; Santos Santos, Nicolas

    2007-01-01

    For transporting industry of natural gas by pipeline systems, it's vital to guarantee the integrity of their lines, in order to decrease operational costs and prevent accidents that may damaging against people's safety, the environment or the infrastructure itself. in this paper it's presented the principal compounds from o technical study about principal net and its distribution branches to municipalities of the National System Transport of Natural Gas pointed by the Colombian Natural Gas Company - ECOGAS, (specifically the Cusiana - Porvenir - La Belleza, La Belleza - Cogua, La Belleza - Vasconia, Vasconia - Neiva and Vasconia - Cali gas lines, (see Figure 1). The principal objective is evaluate the possible condensation of hydrocarbons fluids inside gas lines, due to compositional characteristics of the gas, the different topographical conditions along the gas line route and the actual and future operational conditions to be implemented in the system. The evaluation performed over this gas streams, generates transcendental information in the creation of safe operational limits that minimizing the existence of obstacle problems and damages over pipeline systems and process equipment, due to the presence of liquid hydrocarbons inside these flow lines. This article has been prepared in four sections in order to guarantee easy access to each one of the steps involved in the study. Section one presents the compositional and thermodynamic analysis of feeding gas streams; in section two, its presented the required information for modeling gas lines with definition of the gas pipeline numerical simulation model in stable state; section three presents the sensitivity analysis for gas variation upon loading gas composition at the inlet point of the system, variation of the operational conditions (flow, pressure and gas temperature) and environment temperatures for the different inlet points (branches) with verification of compliance of the Unique Transport Regulation

  8. Bioprocess scale-up/down as integrative enabling technology: from fluid mechanics to systems biology and beyond.

    Science.gov (United States)

    Delvigne, Frank; Takors, Ralf; Mudde, Rob; van Gulik, Walter; Noorman, Henk

    2017-09-01

    Efficient optimization of microbial processes is a critical issue for achieving a number of sustainable development goals, considering the impact of microbial biotechnology in agrofood, environment, biopharmaceutical and chemical industries. Many of these applications require scale-up after proof of concept. However, the behaviour of microbial systems remains unpredictable (at least partially) when shifting from laboratory-scale to industrial conditions. The need for robust microbial systems is thus highly needed in this context, as well as a better understanding of the interactions between fluid mechanics and cell physiology. For that purpose, a full scale-up/down computational framework is already available. This framework links computational fluid dynamics (CFD), metabolic flux analysis and agent-based modelling (ABM) for a better understanding of the cell lifelines in a heterogeneous environment. Ultimately, this framework can be used for the design of scale-down simulators and/or metabolically engineered cells able to cope with environmental fluctuations typically found in large-scale bioreactors. However, this framework still needs some refinements, such as a better integration of gas-liquid flows in CFD, and taking into account intrinsic biological noise in ABM. © 2017 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

  9. Gyroelastic fluids

    Energy Technology Data Exchange (ETDEWEB)

    Kerbel, G.D.

    1981-01-20

    A study is made of a scale model in three dimensions of a guiding center plasma within the purview of gyroelastic (also known as finite gyroradius-near theta pinch) magnetohydrodynamics. The (nonlinear) system sustains a particular symmetry called isorrhopy which permits the decoupling of fluid modes from drift modes. Isorrhopic equilibria are analyzed within the framework of geometrical optics resulting in (local) dispersion relations and ray constants. A general scheme is developed to evolve an arbitrary linear perturbation of a screwpinch equilibrium as an invertible integral transform (over the complete set of generalized eigenfunctions defined naturally by the equilibrium). Details of the structure of the function space and the associated spectra are elucidated. Features of the (global) dispersion relation owing to the presence of gyroelastic stabilization are revealed. An energy principle is developed to study the stability of the tubular screwpinch.

  10. Gyroelastic fluids

    International Nuclear Information System (INIS)

    Kerbel, G.D.

    1981-01-01

    A study is made of a scale model in three dimensions of a guiding center plasma within the purview of gyroelastic (also known as finite gyroradius-near theta pinch) magnetohydrodynamics. The (nonlinear) system sustains a particular symmetry called isorrhopy which permits the decoupling of fluid modes from drift modes. Isorrhopic equilibria are analyzed within the framework of geometrical optics resulting in (local) dispersion relations and ray constants. A general scheme is developed to evolve an arbitrary linear perturbation of a screwpinch equilibrium as an invertible integral transform (over the complete set of generalized eigenfunctions defined naturally by the equilibrium). Details of the structure of the function space and the associated spectra are elucidated. Features of the (global) dispersion relation owing to the presence of gyroelastic stabilization are revealed. An energy principle is developed to study the stability of the tubular screwpinch

  11. Analytical solution for the transient response of a fluid/saturated porous medium halfspace system subjected to an impulsive line source

    Science.gov (United States)

    Shan, Zhendong; Ling, Daosheng; Jing, Liping; Li, Yongqiang

    2018-05-01

    In this paper, transient wave propagation is investigated within a fluid/saturated porous medium halfspace system with a planar interface that is subjected to a cylindrical P-wave line source. Assuming the permeability coefficient is sufficiently large, analytical solutions for the transient response of the fluid/saturated porous medium halfspace system are developed. Moreover, the analytical solutions are presented in simple closed forms wherein each term represents a transient physical wave, especially the expressions for head waves. The methodology utilised to determine where the head wave can emerge within the system is also given. The wave fields within the fluid and porous medium are first defined considering the behaviour of two compressional waves and one tangential wave in the saturated porous medium and one compressional wave in the fluid. Substituting these wave fields into the interface continuity conditions, the analytical solutions in the Laplace domain are then derived. To transform the solutions into the time domain, a suitable distortion of the contour is provided to change the integration path of the solution, after which the analytical solutions in the Laplace domain are transformed into the time domain by employing Cagniard's method. Numerical examples are provided to illustrate some interesting features of the fluid/saturated porous medium halfspace system. In particular, the interface wave and head waves that propagate along the interface between the fluid and saturated porous medium can be observed.

  12. Handbook of hydraulic fluid technology

    CERN Document Server

    Totten, George E

    2011-01-01

    ""The Handbook of Hydraulic Fluid Technology"" serves as the foremost resource for designing hydraulic systems and for selecting hydraulic fluids used in engineering applications. Featuring new illustrations, data tables, as well as practical examples, this second edition is updated with essential information on the latest hydraulic fluids and testing methods. The detailed text facilitates unparalleled understanding of the total hydraulic system, including important hardware, fluid properties, and hydraulic lubricants. Written by worldwide experts, the book also offers a rigorous overview of h

  13. Fracture Propagation, Fluid Flow, and Geomechanics of Water-Based Hydraulic Fracturing in Shale Gas Systems and Electromagnetic Geophysical Monitoring of Fluid Migration

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jihoon; Um, Evan; Moridis, George

    2014-12-01

    We investigate fracture propagation induced by hydraulic fracturing with water injection, using numerical simulation. For rigorous, full 3D modeling, we employ a numerical method that can model failure resulting from tensile and shear stresses, dynamic nonlinear permeability, leak-off in all directions, and thermo-poro-mechanical effects with the double porosity approach. Our numerical results indicate that fracture propagation is not the same as propagation of the water front, because fracturing is governed by geomechanics, whereas water saturation is determined by fluid flow. At early times, the water saturation front is almost identical to the fracture tip, suggesting that the fracture is mostly filled with injected water. However, at late times, advance of the water front is retarded compared to fracture propagation, yielding a significant gap between the water front and the fracture top, which is filled with reservoir gas. We also find considerable leak-off of water to the reservoir. The inconsistency between the fracture volume and the volume of injected water cannot properly calculate the fracture length, when it is estimated based on the simple assumption that the fracture is fully saturated with injected water. As an example of flow-geomechanical responses, we identify pressure fluctuation under constant water injection, because hydraulic fracturing is itself a set of many failure processes, in which pressure consistently drops when failure occurs, but fluctuation decreases as the fracture length grows. We also study application of electromagnetic (EM) geophysical methods, because these methods are highly sensitive to changes in porosity and pore-fluid properties due to water injection into gas reservoirs. Employing a 3D finite-element EM geophysical simulator, we evaluate the sensitivity of the crosswell EM method for monitoring fluid movements in shaly reservoirs. For this sensitivity evaluation, reservoir models are generated through the coupled flow

  14. Investigations into the use of water glycol as the hydraulic fluid in a servo system

    International Nuclear Information System (INIS)

    Cole, G.V.

    1984-07-01

    The effects of water glycol on the performance of a hydraulic system and on the life of the system components have been investigated and a guide to the design of systems using water glycol is given. The dynamic performance of the system using water-glycol was compared with that using mineral oil, then the system was endurance tested to determine its service life. (author)

  15. Equilibres de phases dans les systèmes fluides petroliers-eau Phase Equilibria in Oil-Water Systems

    Directory of Open Access Journals (Sweden)

    Peneloux A.

    2006-11-01

    Full Text Available Nous présentons quelques résultats obtenus à partir du logiciel FHYD qui permet le traitement des mélanges eau-fluides pétroliers, avec la détermination de la nature des phases (huile-gaz-eau-hydrate thermodynamiquement stables dans des conditions données de température et de pression, ainsi que de la quantité, de la composition de ces différentes phases et de leurs propriétés. Ce logiciel permet le tracé automatique des diagrammes de phases et nous présentons des exemples, depuis les systèmes binaires (eau-éthane, ternaires (eau-méthane-propane jusqu'aux fluides les plus complexes. La présence de sels (chlorure de sodium dissous est envisagée, ainsi que le calcul des conditions de dépôt du sel solide. Des exemples de problèmes pétroliers sont cités (gaz de séparateur saturé en eau, huile saturée en eau dans les conditions de gisement, huile en présence d'eau salée. Les estimations sur les quantités d'hydrate formées et leurs compositions sont comparées à des données expérimentales et aux résultats obtenus par d'autres logiciels. Le programme FHYD pourrait permettre une représentation plus réaliste de l'évolution des fluides pétroliers et des propriétés de transport de leurs différentes phases dans les modèles de simulation des conduites polyphasiques. This article presents a selection of results obtained with the FHYD program. This software allows simulation of mixtures composed of petroleum fluids and water, with determination of the nature of thermodynamically stable phases (oil-gas-water-hydrate under given conditions of temperature and pressure, along with the quantity, composition and properties of these different phases. Additionally, the program can automatically produce phase diagrams. Several examples of these have been included here, ranging from binary systems (water-ethane and ternary systems (water-methane-propane to the most complex petroleum fluids. The presence of dissolved salts

  16. Steady-state natural circulation analysis with computational fluid dynamic codes of a liquid metal-cooled accelerator driven system

    International Nuclear Information System (INIS)

    Abanades, A.; Pena, A.

    2009-01-01

    A new innovative nuclear installation is under research in the nuclear community for its potential application to nuclear waste management and, above all, for its capability to enhance the sustainability of nuclear energy in the future as component of a new nuclear fuel cycle in which its efficiency in terms of primary Uranium ore profit and radioactive waste generation will be improved. Such new nuclear installations are called accelerator driven system (ADS) and are the result of a profitable symbiosis between accelerator technology, high-energy physics and reactor technology. Many ADS concepts are based on the utilization of heavy liquid metal (HLM) coolants due to its neutronic and thermo-physical properties. Moreover, such coolants permit the operation in free circulation mode, one of the main aims of passive systems. In this paper, such operation regime is analysed in a proposed ADS design applying computational fluid dynamics (CFD)

  17. Pharmacokinetic study and interaction with the reticulo-endothelial system of a plasma substitute: modified fluid gelatine

    International Nuclear Information System (INIS)

    Vie, M.-T.

    1973-01-01

    By the labelling of a plasma substitute prepared from gelatine, MFG or modified fluid gelatine, it was possible to establish certain facts concerning the kinetics of MFG and its action on the cells of the reticulo-endothelial system. Iodine labelling proved sufficiently reliable to allow the pharmakokinetic exploration of the product by a method which, being relatively simple to use, offers good reproducibility of results. Various tests on the strength of the iodine protein bond showed the stability of the entire protein molecule. A study of the metabolism revealed that the MFG in question behaves towards the organism not as a pure substance but as a mixture of two molecular species of different mass. The experimental results concerning the influence of MFG on the reticulo-endothelial system showed that the phagocyte function is only modified if there is competition between the phagocyted molecule and the MFG [fr

  18. Comparison of Glucose Area Under the Curve Measured Using Minimally Invasive Interstitial Fluid Extraction Technology with Continuous Glucose Monitoring System in Diabetic Patients

    OpenAIRE

    Uemura, Mei

    2017-01-01

    Background: Continuous glucose monitoring (CGM) is reported to be a useful technique, but difficult or inconvenient for some patients and institutions. We are developing a glucose area under the curve (AUC) monitoring system without blood sampling using a minimally invasive interstitial fluid extraction technology (MIET). Here we evaluated the accuracy of interstitial fluid glucose (IG) AUC measured by MIET in patients with diabetes for an extended time interval and the potency of detecting h...

  19. Comparison of Glucose Area Under the Curve Measured Using Minimally Invasive Interstitial Fluid Extraction Technology with Continuous Glucose Monitoring System in Diabetic Patients

    OpenAIRE

    Mei Uemura; Yutaka Yano; Toshinari Suzuki; Taro Yasuma; Toshiyuki Sato; Aya Morimoto; Samiko Hosoya; Chihiro Suminaka; Hiromu Nakajima; Esteban C. Gabazza; Yoshiyuki Takei

    2017-01-01

    Background Continuous glucose monitoring (CGM) is reported to be a useful technique, but difficult or inconvenient for some patients and institutions. We are developing a glucose area under the curve (AUC) monitoring system without blood sampling using a minimally invasive interstitial fluid extraction technology (MIET). Here we evaluated the accuracy of interstitial fluid glucose (IG) AUC measured by MIET in patients with diabetes for an extended time interval and the potency of detecting hy...

  20. Baseline System Costs for 50.0 MW Enhanced Geothermal System -- A Function of: Working Fluid, Technology, and Location, Location, Location

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Paul [Gas Equipment Engineering Corp., Milford, CT (United States); Selman, Nancy [Gas Equipment Engineering Corp., Milford, CT (United States); Volpe, Anthony Della [Gas Equipment Engineering Corp., Milford, CT (United States); Moss, Deborah [Gas Equipment Engineering Corp., Milford, CT (United States); Mobley, Rick [Plasma Energy Services, LLC, Putnam, CT (United States); Dickey, Halley [Turbine Air Systems, Houston, TX (United States); Unruh, Jeffery [Fugro NV/Wm. Lettis & Associates, Houston, TX (United States); Hitchcock, Chris [Fugro NV/Wm. Lettis & Associates, Houston, TX (United States); Tanguay, Jasmine [Conservation Law Foundation/CLF Ventures, Boston, MA (United States); Larsen, Walker [Conservation Law Foundation/CLF Ventures, Boston, MA (United States); Sanyal, Sabir [GeothermEx, Inc., San Pablo, CA (United States); Butler, Steven [GeothermEx, Inc., San Pablo, CA (United States); Stacey, Robert [GeothermEx, Inc., San Pablo, CA (United States); Robertson-Tait, Ann [GeothermEx, Inc., San Pablo, CA (United States); Pruess, Karsten [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Gutoski, Greg [Fairbanks Morse Engines (FME), Beloit, WI (United States); Fay, Jamie M. [Fort Point Associates, Boston, MA (United States); Stitzer, John T. [Fort Point Associates, Boston, MA (United States); Oglesby, Ken [Impact Technologies LLC, Tulsa, OK (United States)

    2012-04-30

    Substantial unexploited opportunity exists for the US, and the world, in Enhanced Geothermal Systems (EGS). As a result of US DOE investment, new drilling technology, new power generation equipment and cycles enable meaningful power production, in a compact and modular fashion; at lower and lower top side EGS working fluid temperatures and in a broader range of geologies and geographies. This cost analysis effort supports the expansion of Enhanced Geothermal Systems (EGS), furthering DOE strategic themes of energy security and sub goal of energy diversity; reducing the Nation's dependence on foreign oil while improving the environment.

  1. Carbon isotope fractionation during diamond growth in depleted peridotite: Counterintuitive insights from modelling water-maximum CHO fluids as multi-component systems

    Science.gov (United States)

    Stachel, T.; Chacko, T.; Luth, R. W.

    2017-09-01

    Because of the inability of depleted cratonic peridotites to effectively buffer oxygen fugacities when infiltrated by CHO or carbonatitic fluids, it has been proposed recently (Luth and Stachel, 2014) that diamond formation in peridotites typically does not occur by rock-buffered redox reactions as previously thought but by an oxygen-conserving reaction in which minor coexisting CH4 and CO2 components in a water-rich fluid react to form diamond (CO2 + CH4 = 2C + 2H2O). In such fluid-buffered systems, carbon isotope fractionation during diamond precipitation occurs in the presence of two dominant fluid carbon species. Carbon isotope modelling of diamond precipitation from mixed CH4- and CO2-bearing fluids reveals unexpected fundamental differences relative to diamond crystallization from a single carbon fluid species: (1) irrespective of which carbon fluid species (CH4 or CO2) is dominant in the initial fluid, diamond formation is invariably associated with progressive minor (diamond in 13C as crystallization proceeds. This is in contrast to diamond precipitation by rock-buffered redox processes from a fluid containing only a single carbon species, which can result in either progressive 13C enrichment (CO2 or carbonate fluids) or 13C depletion (CH4 fluids) in the diamond. (2) Fluid speciation is the key factor controlling diamond δ13 C values; as XCO2 (XCO2 = CO2/[CO2 + CH4]) in the initial fluid increases from 0.1 to 0.9 (corresponding to an increase in fO2 of 0.8 log units), the carbon isotope composition of the first-precipitated diamond decreases by 3.7‰. The tight mode in δ13C of - 5 ± 1 ‰ for diamonds worldwide places strict constraints on the dominant range of XCO2 in water-rich fluids responsible for diamond formation. Specifically, precipitation of diamonds with δ13C values in the range -4 to -6‰ from mantle-derived fluids with an average δ13C value of -5‰ (derived from evidence not related to diamonds) requires that diamond-forming fluids were

  2. Fluid circulation and structural system of Cerritos Colorados geothermal field in La Primavera volcanic caldera (Mexico) inferred from geophysical surveys

    Science.gov (United States)

    Bolós, X.; Cifuentes-Nava, G.; Macias, J. L.; Sosa-Ceballos, G.; García-Tenorio, F.; Albor, M., III; Juarez, M.; Gamez, V.

    2017-12-01

    Hydrothermal activity in volcanic calderas is the consequence of energy transfer between deep magmatic chambers and subsurface layers saturated in water. This hydrothermal system is generated by convection of the groundwater supplied by meteoric water recharged and the ascent of hot volcanic gasses exsolved from deep magma reservoirs. Calderas are heterogeneous geological structures that due to their formation and evolution produced a complex stratigraphy. All of these heterogeneities can be affected by deformation and also by the presence of fractures and faults which constitute the main pathways whereby hydrothermal fluids can move easily through the surface as spring discharges and fumarolic activity. Geophysical methods have been used in the last decades to investigate the relationship between structural geology and hydrothermal systems in different volcanic areas around the world. In this work, we have focused on the role of subsurface structures to understand and localize the pathways of fluids related to the hydrothermal system of the Cerritos Colorados geothermal field. We focused in the central area of the caldera (P12 well and Cerritos Colorados graben), where active hydrothermal activity is evidenced by fumaroles, thermal anomalies, CO2 diffuse emission, and sulfur precipitation. We have applied a self-potential method (SP) that combined with temperature measurements that allowed to identify the main infiltration and ascending fluid zones in the area, and their specific surface temperature coinciding with fumarolic activity. From this data we an applied Electrical Resistivity Tomography (ERT) survey in two selected places. One ERT profile (1.2 km in length) was located in the P12 well area. A 3D resistivity model used with the equatorial method was carried out on the Cerritos Colorados graben area. Combining the results of the SP, TºC, and ERT data with a detailed structural map we identified the main degassing zones (i.e. fumaroles) that correspond to

  3. Buffer fluid

    Energy Technology Data Exchange (ETDEWEB)

    Mirzadzhanzade, A Kh; Dedusanko, G Ya; Dinaburg, L S; Markov, Yu M; Rasizade, Ya N; Rozov, V N; Sherstnev, N M

    1979-08-30

    A drilling fluid is suggested for separating the drilling and plugging fluids which contains as the base increased solution of polyacrylamide and additive. In order to increase the viscoelastic properties of the liquid with simultaneous decrease in the periods of its fabrication, the solution contains as an additive dry bentonite clay. In cases of the use of a buffer fluid under conditions of negative temperatures, it is necessary to add to it table salt or ethylene glycol.

  4. Approach to uncertainty assessment for fluid flow and contaminant transport modeling in heterogeneous groundwater systems

    International Nuclear Information System (INIS)

    Nelson, R.W.; Jacobson, E.A.; Conbere, W.

    1985-06-01

    There is a growing awareness of the need to quantify uncertainty in groundwater flow and transport model results. Regulatory organizations are beginning to request the statistical distributions of predicted contaminant arrival to the biosphere, so that realistic confidence intervals can be obtained for the modeling results. To meet these needs, methods are being developed to quantify uncertainty in the subsurface flow and transport analysis sequence. A method for evaluating this uncertainty, described in this paper, considers uncertainty in material properties and was applied to an example field problem. Our analysis begins by using field measurements of transmissivity and hydraulic head in a regional, parameter estimation method to obtain a calibrated fluid flow model and a covariance matrix of the parameter estimation errors. The calibrated model and the covariance matrix are next used in a conditional simulation mode to generate a large number of 'head realizations.' The specific pore water velocity distribution for each realization is calculated from the effective porosity, the aquifer parameter realization, and the associated head values. Each velocity distribution is used to obtain a transport solution for a contaminant originating from the same source for all realizations. The results are the statistical distributions for the outflow arrival times. The confidence intervals for contamination reaching the biosphere are obtained from the outflow statistical distributions. 20 refs., 12 figs

  5. The IGF-I/IGFBP-3 system in gingival crevicular fluid and dependence on application of fixed force.

    Science.gov (United States)

    Toia, M; Galazzo, R; Maioli, C; Granata, R; Scarlatti, F

    2005-12-01

    During application of orthodontic force on the tooth, various molecular parameters associated with tissue remodeling are changed. IGF-I is a regulatory protein produced during periodontal regeneration. IGF binding proteins-3 (IGFBP-3), a specific IGF-I binding protein, is the major regulatory factor of IGF-I activity. We tested the hypothesis that changes in the IGF-I/ IGFBP-3 system occur during fixed force application to the tooth and that these changes are detectable in the gingival crevicular fluid (GCF). IGFBP-3 and IGF-I secretion into gingival crevicular fluid (GCF) was analyzed by Western blotting and immunoradiometric assay (IRMA), respectively, in GCF of 6 healthy subjects just prior to and during orthodontics treatment using fixed appliances. We observed a significant time-dependent decrease of IGFBP-3 content in GCF during orthodontic treatment (4 h and 10 days). Reduction in levels of intact, glycosylated 47 kDa form of IGFBP-3 was associated with its degradation and the appearance of intermediate breakdown products. IGF-I levels were significantly increased 4 h after application of orthodontic force, while they were significantly reduced 10 days after the start of treatment. IGFBP-3 secretion into GCF and its molecular structure are modified by the fixed force of orthodontic treatment. Alterations in IGFBP-3 appear to be unrelated to the binding to IGF-I, suggesting an IGF-independent role of this binding protein in tooth movement.

  6. Description and characterization of the novel hyperthermia- and thermoablation-system MFHregistered300F for clinical magnetic fluid hyperthermia

    International Nuclear Information System (INIS)

    Gneveckow, Uwe; Jordan, Andreas; Scholz, Regina; Bruess, Volker; Waldoefner, Norbert; Ricke, Jens; Feussner, Annelie; Hildebrandt, Bert; Rau, Beate; Wust, Peter

    2004-01-01

    Magnetic fluid hyperthermia (MFH) is a new approach to deposit heat power in deep tissues by overcoming limitations of conventional heat treatments. After infiltration of the target tissue with nanosized magnetic particles, the power of an alternating magnetic field is transformed into heat. The combination of the 100 kHz magnetic field applicator MFH registered 300F and the magnetofluid (MF), which both are designed for medical use, is investigated with respect to its dosage recommendations and clinical applicability. We found a magnetic field strength of up to 18 kA/m in a cylindrical treatment area of 20 cm diameter and aperture height up to 300 mm. The specific absorption rate (SAR) can be controlled directly by the magnetic field strength during the treatment. The relationship between magnetic field strength and the iron normalized SAR (SAR Fe ) is only slightly depending on the concentration of the MF and can be used for planning the target SAR. The achievable energy absorption rates of the MF distributed in the tissue is sufficient for either hyperthermia or thermoablation. The fluid has a visible contrast in therapeutic concentrations on a CT scanner and can be detected down to 0.01 g/l Fe in the MRI. The system has proved its capability and practicability for heat treatment in deep regions of the human body

  7. Concerning the Effect of a Viscoelastic Foundation on the Dynamic Stability of a Pipeline System Conveying an Incompressible Fluid

    Directory of Open Access Journals (Sweden)

    Vincent Olunloyo

    2016-12-01

    Full Text Available In this paper, we present an analytical method for solving a well-posed boundary value problem of mathematical physics governing the vibration characteristics of an internal flow propelled fluid-structure interaction where the pipeline segment is idealized as an elastic hollow beam conveying an incompressible fluid on a viscoelastic foundation. The effect of Coriolis and damping forces on the overall dynamic response of the system is investigated. In actuality, for a pipe segment supported at both ends and subject to a free motion, these two forces generate conjugate complex frequencies for all flow velocities. On employing integral transforms and complex variable functions, a closed form analytical expression is derived for the overall dynamic response. It is demonstrated that a concise mathematical expression for the natural frequency associated with any mode of vibration can be deduced from the algebraic product of the complex frequency pairs. By a way of comparative analysis for damping decrement physics reminiscent with laminated structures, mathematical expressions are derived to illustrate viscoelastic damping effects on dynamic stability for any flow velocity. The integrity of the analytical solution is verified and validated by confirming theresults in literature in appropriate asymptotic limits.

  8. Development and validation of spectroscopic methods for monitoring density changes in pressurized gaseous and supercritical fluid systems.

    Science.gov (United States)

    Blatchford, Marc A; Wallen, Scott L

    2002-04-15

    The further development of new processes utilizing liquid or supercritical CO2 as a solvent will benefit from the rational design of new CO2-philes. Understanding solvation structures and mechanisms of these molecules is an important part of this process. In such studies, determining the change in density as a function of the measured thermodynamic conditions (pressure and temperature) provides an excellent means of directly monitoring the solution conditions in the detection volume for a given technique. By integrating spectroscopic peaks, changes in area can be used to determine changes in analyte concentration in the detection volume, and thus, it should be possible to monitor the system density in situ. In the present study, we examine the utility of Raman and NMR spectroscopy as a means of following changes in solution density conditions and validate this approach in pure fluids and gases (N2 and CO2) and supercritical fluid mixtures (acetaldehyde vapor in N2). In addition, we present the design of a simple, inexpensive cell for conducting Raman and NMR measurements under moderate pressure conditions.

  9. Large-scale thermal convection of viscous fluids in a faulted system: 3D test case for numerical codes

    Science.gov (United States)

    Magri, Fabien; Cacace, Mauro; Fischer, Thomas; Kolditz, Olaf; Wang, Wenqing; Watanabe, Norihiro

    2017-04-01

    In contrast to simple homogeneous 1D and 2D systems, no appropriate analytical solutions exist to test onset of thermal convection against numerical models of complex 3D systems that account for variable fluid density and viscosity as well as permeability heterogeneity (e.g. presence of faults). Owing to the importance of thermal convection for the transport of energy and minerals, the development of a benchmark test for density/viscosity driven flow is crucial to ensure that the applied numerical models accurately simulate the physical processes at hands. The presented study proposes a 3D test case for the simulation of thermal convection in a faulted system that accounts for temperature dependent fluid density and viscosity. The linear stability analysis recently developed by Malkovsky and Magri (2016) is used to estimate the critical Rayleigh number above which thermal convection of viscous fluids is triggered. The numerical simulations are carried out using the finite element technique. OpenGeoSys (Kolditz et al., 2012) and Moose (Gaston et al., 2009) results are compared to those obtained using the commercial software FEFLOW (Diersch, 2014) to test the ability of widely applied codes in matching both the critical Rayleigh number and the dynamical features of convective processes. The methodology and Rayleigh expressions given in this study can be applied to any numerical model that deals with 3D geothermal processes in faulted basins as by example the Tiberas Basin (Magri et al., 2016). References Kolditz, O., Bauer, S., Bilke, L., Böttcher, N., Delfs, J. O., Fischer, T., U. J. Görke, T. Kalbacher, G. Kosakowski, McDermott, C. I., Park, C. H., Radu, F., Rink, K., Shao, H., Shao, H.B., Sun, F., Sun, Y., Sun, A., Singh, K., Taron, J., Walther, M., Wang,W., Watanabe, N., Wu, Y., Xie, M., Xu, W., Zehner, B., 2012. OpenGeoSys: an open-source initiative for numerical simulation of thermo-hydro-mechanical/chemical (THM/C) processes in porous media. Environmental

  10. COUPLED CHEMOTAXIS FLUID MODEL

    KAUST Repository

    LORZ, ALEXANDER

    2010-01-01

    We consider a model system for the collective behavior of oxygen-driven swimming bacteria in an aquatic fluid. In certain parameter regimes, such suspensions of bacteria feature large-scale convection patterns as a result of the hydrodynamic

  11. Energy Optimal Tracking Control with Discrete Fluid Power Systems using Model Predictive Control

    DEFF Research Database (Denmark)

    Hansen, Anders Hedegaard; Asmussen, Magnus Færing; Bech, Michael Møller

    2017-01-01

    For Discrete Displacement Cylinder (DDC) drives the control task lies in choosing force level. Hence, which force level to apply and thereby which pressure level each cylinder chambers shall be connected to. The DDC system is inherently a force system why often a force reference is generated...... and compared to a PID like tracking controller combined with a FSA. The results indicate that the energy efficiency of position tracking DDC systems may be improved significantly by using the MPC algorithm....

  12. Development of Fluid and I and C Systems Design Technology for LMR - Development of mechanical structure design technology for LMR

    International Nuclear Information System (INIS)

    Lee, Jae Han; Joo, Young Sang; Lee, Hueong Yeon and others

    2005-03-01

    The key research items during the fiscal years of Phase 3 of the mechanical design technology development for liquid metal reactor are described. The objective of this project is to develop the design technology for the mechanical system of 600MWe, pool type liquid metal reactor with sodium coolant, and the structural integrity evaluation technology for mechanical system of the reactor system, structures and equipments. In the design technology development for mechanical structures, the reactor internal structures, reactor head and piping system, reactor containment structures have been studied, and new structural concepts compatible with the new reactor have been proposed. The thermal protection devices of reactor vessel and the refueling system have been conceptually established and the feasibility study for 3-D seismic isolation of reactor building was performed. The structural damage detection technology for reactor internal structures has been studied and its application has been confirmed. In the structural integrity evaluation technology development, the sensitivities of material constants for inelastic analysis codes have been studied and the applicabilities of the developed codes are enhanced. The high temperature creep-fatigue structural behavior test has been conducted so that high temperature structural damage test and evaluation technology were ensured at first in domestic. The high temperature seismic buckling analysis method to evaluate the buckling of thin reactor shell structure under the transient thermal load was established. In addition, the core seismic response analysis code reflected the fluid effect of core was developed and its accuracy was confirmed with a scale-down model test

  13. Microgravity Fluids for Biology, Workshop

    Science.gov (United States)

    Griffin, DeVon; Kohl, Fred; Massa, Gioia D.; Motil, Brian; Parsons-Wingerter, Patricia; Quincy, Charles; Sato, Kevin; Singh, Bhim; Smith, Jeffrey D.; Wheeler, Raymond M.

    2013-01-01

    Microgravity Fluids for Biology represents an intersection of biology and fluid physics that present exciting research challenges to the Space Life and Physical Sciences Division. Solving and managing the transport processes and fluid mechanics in physiological and biological systems and processes are essential for future space exploration and colonization of space by humans. Adequate understanding of the underlying fluid physics and transport mechanisms will provide new, necessary insights and technologies for analyzing and designing biological systems critical to NASAs mission. To enable this mission, the fluid physics discipline needs to work to enhance the understanding of the influence of gravity on the scales and types of fluids (i.e., non-Newtonian) important to biology and life sciences. In turn, biomimetic, bio-inspired and synthetic biology applications based on physiology and biology can enrich the fluid mechanics and transport phenomena capabilities of the microgravity fluid physics community.

  14. Fluid dynamic design and analysis of a highly loaded Centrifugal rotor for mini orc power systems

    NARCIS (Netherlands)

    Vitale, S.; Pini, M.; Ghidoni, A.; Colonna di Paliano, P.

    2015-01-01

    Organic Rankine Cycle (ORC) power systems are a well-established technology for the conversion of thermal energy sources in the small-to-medium power range. In the last few years, efforts have been devoted to the development of mini ORC (mORC) power systems (5- 30 kWe) for waste heat recovery from

  15. Evolution of a neutral-ion 2 fluid system using thermal lattice Boltzmann model

    International Nuclear Information System (INIS)

    Vahala, L.; Vahala, G.; Carter, J.; Pavlo, P.

    2000-01-01

    The 2D evolution of a 2-species system is examined using the thermal lattice Boltzmann model (TLBM). The effects of velocity shear layers on sharp heat fronts are considered for a neutral-ion system in the case where both species are turbulent. The rate at which the species velocities and temperatures equilibrate no longer follow the Morse estimate. (author)

  16. Heat flux from magmatic hydrothermal systems related to availability of fluid recharge

    Science.gov (United States)

    Harvey, M. C.; Rowland, J.V.; Chiodini, G.; Rissmann, C.F.; Bloomberg, S.; Hernandez, P.A.; Mazot, A.; Viveiros, F.; Werner, Cynthia A.

    2015-01-01

    Magmatic hydrothermal systems are of increasing interest as a renewable energy source. Surface heat flux indicates system resource potential, and can be inferred from soil CO2 flux measurements and fumarole gas chemistry. Here we compile and reanalyze results from previous CO2 flux surveys worldwide to compare heat flux from a variety of magma-hydrothermal areas. We infer that availability of water to recharge magmatic hydrothermal systems is correlated with heat flux. Recharge availability is in turn governed by permeability, structure, lithology, rainfall, topography, and perhaps unsurprisingly, proximity to a large supply of water such as the ocean. The relationship between recharge and heat flux interpreted by this study is consistent with recent numerical modeling that relates hydrothermal system heat output to rainfall catchment area. This result highlights the importance of recharge as a consideration when evaluating hydrothermal systems for electricity generation, and the utility of CO2 flux as a resource evaluation tool.

  17. Schroedinger fluid

    International Nuclear Information System (INIS)

    Kan, K.K.

    1983-01-01

    The relationship of nuclear internal flow and collective inertia, the difference of this flow from that of a classical fluid, and the approach of this flow to rigid flow in independent-particle model rotation are elucidated by reviewing the theory of Schroedinger fluid and its implications for collective vibration and rotation. (author)

  18. Modeling of Compressible Flow with Friction and Heat Transfer Using the Generalized Fluid System Simulation Program (GFSSP)

    Science.gov (United States)

    Bandyopadhyay, Alak; Majumdar, Alok

    2007-01-01

    The present paper describes the verification and validation of a quasi one-dimensional pressure based finite volume algorithm, implemented in Generalized Fluid System Simulation Program (GFSSP), for predicting compressible flow with friction, heat transfer and area change. The numerical predictions were compared with two classical solutions of compressible flow, i.e. Fanno and Rayleigh flow. Fanno flow provides an analytical solution of compressible flow in a long slender pipe where incoming subsonic flow can be choked due to friction. On the other hand, Raleigh flow provides analytical solution of frictionless compressible flow with heat transfer where incoming subsonic flow can be choked at the outlet boundary with heat addition to the control volume. Nonuniform grid distribution improves the accuracy of numerical prediction. A benchmark numerical solution of compressible flow in a converging-diverging nozzle with friction and heat transfer has been developed to verify GFSSP's numerical predictions. The numerical predictions compare favorably in all cases.

  19. Review article: closed-loop systems in anesthesia: is there a potential for closed-loop fluid management and hemodynamic optimization?

    Science.gov (United States)

    Rinehart, Joseph; Liu, Ngai; Alexander, Brenton; Cannesson, Maxime

    2012-01-01

    Closed-loop (automated) controllers are encountered in all aspects of modern life in applications ranging from air-conditioning to spaceflight. Although these systems are virtually ubiquitous, they are infrequently used in anesthesiology because of the complexity of physiologic systems and the difficulty in obtaining reliable and valid feedback data from the patient. Despite these challenges, closed-loop systems are being increasingly studied and improved for medical use. Two recent developments have made fluid administration a candidate for closed-loop control. First, the further description and development of dynamic predictors of fluid responsiveness provides a strong parameter for use as a control variable to guide fluid administration. Second, rapid advances in noninvasive monitoring of cardiac output and other hemodynamic variables make goal-directed therapy applicable for a wide range of patients in a variety of clinical care settings. In this article, we review the history of closed-loop controllers in clinical care, discuss the current understanding and limitations of the dynamic predictors of fluid responsiveness, and examine how these variables might be incorporated into a closed-loop fluid administration system.

  20. The Borexino Thermal Monitoring & Management System and simulations of the fluid-dynamics of the Borexino detector under asymmetrical, changing boundary conditions

    Science.gov (United States)

    Bravo-Berguño, D.; Mereu, R.; Cavalcante, P.; Carlini, M.; Ianni, A.; Goretti, A.; Gabriele, F.; Wright, T.; Yokley, Z.; Vogelaar, R. B.; Calaprice, F.; Inzoli, F.

    2018-03-01

    A comprehensive monitoring system for the thermal environment inside the Borexino neutrino detector was developed and installed in order to reduce uncertainties in determining temperatures throughout the detector. A complementary thermal management system limits undesirable thermal couplings between the environment and Borexino's active sections. This strategy is bringing improved radioactive background conditions to the region of interest for the physics signal thanks to reduced fluid mixing induced in the liquid scintillator. Although fluid-dynamical equilibrium has not yet been fully reached, and thermal fine-tuning is possible, the system has proven extremely effective at stabilizing the detector's thermal conditions while offering precise insights into its mechanisms of internal thermal transport. Furthermore, a Computational Fluid-Dynamics analysis has been performed, based on the empirical measurements provided by the thermal monitoring system, and providing information into present and future thermal trends. A two-dimensional modeling approach was implemented in order to achieve a proper understanding of the thermal and fluid-dynamics in Borexino. It was optimized for different regions and periods of interest, focusing on the most critical effects that were identified as influencing background concentrations. Literature experimental case studies were reproduced to benchmark the method and settings, and a Borexino-specific benchmark was implemented in order to validate the modeling approach for thermal transport. Finally, fully-convective models were applied to understand general and specific fluid motions impacting the detector's Active Volume.

  1. Thermo-Economic and Heat Transfer Optimization of Working-Fluid Mixtures in a Low-Temperature Organic Rankine Cycle System

    Directory of Open Access Journals (Sweden)

    Oyeniyi A. Oyewunmi

    2016-06-01

    Full Text Available In the present paper, we consider the employment of working-fluid mixtures in organic Rankine cycle (ORC systems with respect to thermodynamic and heat-transfer performance, component sizing and capital costs. The selected working-fluid mixtures promise reduced exergy losses due to their non-isothermal phase-change behaviour, and thus improved cycle efficiencies and power outputs over their respective pure-fluid components. A multi-objective cost-power optimization of a specific low-temperature ORC system (operating with geothermal water at 98 °C reveals that the use of working-fluid-mixtures does indeed show a thermodynamic improvement over the pure-fluids. At the same time, heat transfer and cost analyses, however, suggest that it also requires larger evaporators, condensers and expanders; thus, the resulting ORC systems are also associated with higher costs. In particular, 50% n-pentane + 50% n-hexane and 60% R-245fa + 40% R-227ea mixtures lead to the thermodynamically optimal cycles, whereas pure n-pentane and pure R-245fa have lower plant costs, both estimated as having ∼14% lower costs per unit power output compared to the thermodynamically optimal mixtures. These conclusions highlight the importance of using system cost minimization as a design objective for ORC plants.

  2. Modeling and Design of an Electro-Rheological Fluid Based Haptic System for Tele-Operation of Space Robots

    Science.gov (United States)

    Mavroidis, Constantinos; Pfeiffer, Charles; Paljic, Alex; Celestino, James; Lennon, Jamie; Bar-Cohen, Yoseph

    2000-01-01

    For many years, the robotic community sought to develop robots that can eventually operate autonomously and eliminate the need for human operators. However, there is an increasing realization that there are some tasks that human can perform significantly better but, due to associated hazards, distance, physical limitations and other causes, only robot can be employed to perform these tasks. Remotely performing these types of tasks requires operating robots as human surrogates. While current "hand master" haptic systems are able to reproduce the feeling of rigid objects, they present great difficulties in emulating the feeling of remote/virtual stiffness. In addition, they tend to be heavy, cumbersome and usually they only allow limited operator workspace. In this paper a novel haptic interface is presented to enable human-operators to "feel" and intuitively mirror the stiffness/forces at remote/virtual sites enabling control of robots as human-surrogates. This haptic interface is intended to provide human operators intuitive feeling of the stiffness and forces at remote or virtual sites in support of space robots performing dexterous manipulation tasks (such as operating a wrench or a drill). Remote applications are referred to the control of actual robots whereas virtual applications are referred to simulated operations. The developed haptic interface will be applicable to IVA operated robotic EVA tasks to enhance human performance, extend crew capability and assure crew safety. The electrically controlled stiffness is obtained using constrained ElectroRheological Fluids (ERF), which changes its viscosity under electrical stimulation. Forces applied at the robot end-effector due to a compliant environment will be reflected to the user using this ERF device where a change in the system viscosity will occur proportionally to the force to be transmitted. In this paper, we will present the results of our modeling, simulation, and initial testing of such an

  3. Developing Computational Fluid Dynamics (CFD Models to Evaluate Available Energy in Exhaust Systems of Diesel Light-Duty Vehicles

    Directory of Open Access Journals (Sweden)

    Pablo Fernández-Yáñez

    2017-06-01

    Full Text Available Around a third of the energy input in an automotive engine is wasted through the exhaust system. Since numerous technologies to harvest energy from exhaust gases are accessible, it is of great interest to find time- and cost-efficient methods to evaluate available thermal energy under different engine conditions. Computational fluid dynamics (CFD is becoming a very valuable tool for numerical predictions of exhaust flows. In this work, a methodology to build a simple three-dimensional (3D model of the exhaust system of automotive internal combustion engines (ICE was developed. Experimental data of exhaust gas in the most used part of the engine map in passenger diesel vehicles were employed as input for calculations. Sensitivity analyses of different numeric schemes have been conducted in order to attain accurate results. The model built allows for obtaining details on temperature and pressure fields along the exhaust system, and for complementing the experimental results for a better understanding of the flow phenomena and heat transfer through the system for further energy recovery devices.

  4. Method and means for abruptly terminating the flow of fluid in closed circulating systems of nuclear reactor plants or the like

    International Nuclear Information System (INIS)

    Schiele, O.; Florjancic, D.

    1976-01-01

    A nuclear steam supply system is described wherein each of a plurality of centrifugal pumps begins to operate with full cavitation in response to an abrupt drop of system pressure in the event of leakage. This is achieved by influencing the net positive suction head of each pump over the entire range of fluid flow and/or by influencing the net positive suction head upstream of the pumps. The first mode of causing the pumps to operate with full cavitation includes an appropriate selection of the inlet angle and/or inlet diameter of the pump impeller, the provision of auxiliary impellers which are located upstream of the pumps and can circulate the fluid in or counter to the direction of rotation of the respective pump impellers, or the provision of suitably curved guide vanes in the pumps. The second mode include interrupting the admission of undercooled fluid into the system upstream of the pumps

  5. DIAGNOSTIC CARDIAC CATHETERIZATION USING THE MEDRAD AVANTA FLUID MANAGEMENT SYSTEM AS COMPARED TO THE TRADITIONAL MANUAL INJECTION METHOD

    Energy Technology Data Exchange (ETDEWEB)

    Winniford, Michael D

    2013-02-08

    Nearly 4 million patient procedures performed annually in US cardiac catheterization laboratories utilize contrast media to achieve vessel opacification. The amount of contrast media used is variable and depends on the complexity of the procedure, the method of contrast delivery as well as the skill-level of the operator. Since the total amount of contrast used for each procedure can have both patient safety and economic implications, it is essential for cardiologists to have the ability to control contrast delivery such that optimal angiographic image quality is achieved using the least amount of contrast. Although the complication rate associated with cardiac catheterization remains low, the most common serious complication, contrast-induced nephropathy (CIN), is associated with poor prognosis and a high mortality rate. Numerous interventional strategies for preventing and reducing the severity of CIN have demonstrated varying degrees of clinical benefit, but none has been shown to reliably prevent this serious complication. To date, the most effective approach for reducing the risk of CIN is to properly hydrate the patient and to minimize the amount of contrast media administered. Automated injection systems are intended for use in virtually all cardiac catheterization procedures and have numerous features which can provide potential advantages over traditional methods. With automated injection technology the operator is able to control and precisely monitor contrast delivery. Additionally, the MEDRAD Avanta Fluid Management Injection System utilizes a sterile contrast reservoir which eliminates the need to discard unused contrast in individual opened containers following each procedure. Considering that an average of 50% of opened contrast media is wasted using manual injection methods, this savings can provide a substantial economic benefit. Automated systems also facilitate the use of smaller (5 French) catheter sizes. Precise flow control and the use of

  6. Vascular mechanotransduction data in a rodent model of diabetes: Pressure-induced regulation of SHP2 and associated signaling in the rat inferior vena cava

    Directory of Open Access Journals (Sweden)

    Kevin M. Rice

    2017-12-01

    Full Text Available The effect of diabetes on vascular mechano-transductive response is of great concern. Given the higher rate of vein graft failures associated with diabetes, understanding the multiple cellular and molecular events associated with vascular remodeling is of vital importance. This article represents data related to a study published in Cardiovascular Diabetology [1] (Rice et al., 2006 and Open Journal of Endocrine and Metabolic Diseases [2] (Rice et al., 2015 evaluating the effect of pressurization on rat inferior venae cavae (IVC. Provided within this articles is information related to the method and processing of raw data related to our prior publish work and Data in Brief articles [3,4] (Rice et al., 2017, as well as the evaluation of alternation in SHP-2 signaling and associated proteins in response to mechanical force. IVC from lean and obese animals were exposed to a 30 min perfusion of 120 mm Hg pressure and evaluated for changes in expression of SHP2, BCL-3, BCL-XL, HSP 27, HSP 70, and PI3K p85, along with the phosphorylation of SHP-2 (Tyr 542.

  7. Design of a nanocomposite substrate inducing adult stem cell assembly and progression toward an Epiblast-like or Primitive Endoderm-like phenotype via mechanotransduction.

    Science.gov (United States)

    Morena, Francesco; Armentano, Ilaria; Montanucci, Pia; Argentati, Chiara; Fortunati, Elena; Montesano, Simona; Bicchi, Ilaria; Pescara, Teresa; Pennoni, Ilaria; Mattioli, Samantha; Torre, Luigi; Latterini, Loredana; Emiliani, Carla; Basta, Giuseppe; Calafiore, Riccardo; Kenny, Josè Maria; Martino, Sabata

    2017-11-01

    This work shows that the active interaction between human umbilical cord matrix stem cells and Poly (l-lactide)acid (PLLA) and PLLA/Multi Walled Carbon Nanotubes (MWCNTs) nanocomposite films results in the stem cell assembly as a spheroid conformation and affects the stem cell fate transition. We demonstrated that spheroids directly respond to a tunable surface and the bulk properties (electric, dielectric and thermal) of plain and nanocomposite PLLA films by triggering a mechanotransduction axis. This stepwise process starts from tethering of the cells' focal adhesion proteins to the surface, together with the adherens junctions between cells. Both complexes transmit traction forces to F-Actin stress fibres that link Filamin-A and Myosin-IIA proteins, generating a biological scaffold, with increased stiffening conformation from PLLA to PLLA/MWCNTs, and enable the nucleoskeleton proteins to boost chromatin reprogramming processes. Herein, the opposite expression of NANOG and GATA6 transcription factors, together with other lineage specification related proteins, steer spheroids toward an Epiblast-like or Primitive Endoderm-like lineage commitment, depending on the absence or presence of 1 wt% MWCNTs, respectively. This work represents a pioneering effort to create a stem cell/material interface that can model the stem cell fate transition under growth culture conditions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  8. Investigation and Optimisation of a Discrete Fluid Power PTO-system for Wave Energy Converters

    DEFF Research Database (Denmark)

    Hansen, Anders Hedegaard

    Patents on ocean wave energy dates back to 1799, however no wave energy converter (WEC) concept have a commercialised device. The cost of energy produced with wave energy converters is very high compared to traditional energy sources. Even when compared to energy from wind turbines wave energy...... investigation show how the wave climate naturally influence the optimal system configuration yielding maximal energy output, and how one may choose the system configuration based on the installation site. The switching manifold is the control element of the secondary controlled force system. The force...... needs cost reductions. Hence, next to political will, the main obstacle for a commercial break through of wave energy technology is the high cost of energy. Initiatives to lower costs are made in areas of minimising structural costs and increasing the energy production per device. Wave Star A/S has...

  9. Isotopic evidence for the infiltration of mantle and metamorphic CO2-H2O fluids from below in faulted rocks from the San Andreas Fault System

    Energy Technology Data Exchange (ETDEWEB)

    Pili, E.; Kennedy, B.M.; Conrad, M.E.; Gratier, J.-P.

    2010-12-15

    To characterize the origin of the fluids involved in the San Andreas Fault (SAF) system, we carried out an isotope study of exhumed faulted rocks from deformation zones, vein fillings and their hosts and the fluid inclusions associated with these materials. Samples were collected from segments along the SAF system selected to provide a depth profile from upper to lower crust. In all, 75 samples from various structures and lithologies from 13 localities were analyzed for noble gas, carbon, and oxygen isotope compositions. Fluid inclusions exhibit helium isotope ratios ({sup 3}He/{sup 4}He) of 0.1-2.5 times the ratio in air, indicating that past fluids percolating through the SAF system contained mantle helium contributions of at least 35%, similar to what has been measured in present-day ground waters associated with the fault (Kennedy et al., 1997). Calcite is the predominant vein mineral and is a common accessory mineral in deformation zones. A systematic variation of C- and O-isotope compositions of carbonates from veins, deformation zones and their hosts suggests percolation by external fluids of similar compositions and origin with the amount of fluid infiltration increasing from host rocks to vein to deformation zones. The isotopic trend observed for carbonates in veins and deformation zones follows that shown by carbonates in host limestones, marbles, and other host rocks, increasing with increasing contribution of deep metamorphic crustal volatiles. At each crustal level, the composition of the infiltrating fluids is thus buffered by deeper metamorphic sources. A negative correlation between calcite {delta}{sup 13}C and fluid inclusion {sup 3}He/{sup 4}He is consistent with a mantle origin for a fraction of the infiltrating CO{sub 2}. Noble gas and stable isotope systematics show consistent evidence for the involvement of mantle-derived fluids combined with infiltration of deep metamorphic H{sub 2}O and CO{sub 2} in faulting, supporting the involvement of

  10. A Novel Organic Rankine Cycle System with Improved Thermal Stability and Low Global Warming Fluids

    Directory of Open Access Journals (Sweden)

    Panesar Angad S

    2014-07-01

    Full Text Available This paper proposes a novel Organic Rankine Cycle (ORC system for long haul truck application. Rather than typical tail pipe heat recovery configurations, the proposed setup exploits the gaseous streams that are already a load on the engine cooling module. The system uses dual loops connected only by the Exhaust Gas Recirculation (EGR stream. A water blend study is conducted to identify suitable mixtures for the High Temperature (HT loop, while the Low Temperature (LT loop utilises a Low Global Warming (GWP Hydrofluoroether.

  11. Green line fracturing systems fluids in Campos Basin, Brazil; Sistemas de fluidos de fraturamento na Bacia de Campos: evolucao em beneficio do meio ambiente

    Energy Technology Data Exchange (ETDEWEB)

    Melo, Alexandre B. de; Araujo, Cosme J.C. de; Martinho, Flavio M.; Gaspar, Fernando [BJ Services do Brasil, Rio de Janeiro, RJ (Brazil)

    2008-07-01

    The constant demand for Services Companies in Oil and Gas Industry to reduce the environmental impacts has led to a race in search of new cleaner technologies. Fluids with low toxicity are the target of research and development by the companies which are committed to ensure the aspects of quality, health, safety and environment from manufacturing up to the use in the final destination of these products. The replacement of these fluids is happening at a larger speed than in the past on the based in two factors: greater awareness on the part of these companies in relation to the environmental and by new environmental laws. The fluids systems used in fracturing operations are not an exception to this rule. Service companies today are in the process of replacing their formulations with systems less aggressive to the environment so-called 'green' systems. In this context the new technological developments of fracturing fluids are of fundamental importance to assist the new environmental requirements of both operators and government regulatory bodies and also to ensure better effectiveness of these products. This paper reports the research, development and application of new environmentally acceptable fracturing fluids technology, reviews the pioneering case histories in offshore operations and the benefits experienced in the Campos Basin - Brazil. (author)

  12. On the Versatility of Rheoreversible, Stimuli-responsive Hydraulic-Fracturing Fluids for Enhanced Geothermal Systems: Effect of Reservoir pH

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Carlos A.; Shao, Hongbo; Bonneville, Alain; Varga, Tamas; Zhong, Lirong

    2016-04-25

    Abstract The primary challenge for the feasibility of enhanced geothermal systems (EGS) is to cost-effectively create high-permeability reservoirs inside deep crystalline bedrock. Although fracturing fluids are commonly used for oil/gas, standard fracturing methods are not developed or proven for EGS temperatures and pressures. Furthermore, the environmental impacts of currently used fracturing methods are only recently being determined. These authors recently reported an environmentally benign, CO2-activated, rheoreversible fracturing fluid that enhances permeability through fracturing due to in situ volume expansion and gel formation. The potential of this novel fracturing fluid is evaluated in this work towards its application at geothermal sites under different pH conditions. Laboratory-scale fracturing experiments using Coso Geothermal rock cores under different pH environments were performed followed by X-ray microtomography characterization. The results demonstrate that CO2-reactive aqueous solutions of environmentally amenable polyallylamine (PAA) consistently and reproducibly creates/propagates fracture networks through highly impermeable crystalline rock from Coso EGS sites at considerably lower effective stress as compared to conventional fracturing fluids. In addition, permeability was significantly enhanced in a wide range of formation-water pH values. This effective, and environmentally-friendly fracturing fluid technology represents a potential alternative to conventional fracturing fluids.

  13. High-pressure fluid-phase equilibria: Experimental methods and systems investigated (2000-2004)

    DEFF Research Database (Denmark)

    Dohrn, Ralf; Peper, Stephanie; Fonseca, José

    2010-01-01

    As a part of a series of reviews, a compilation of systems for which high-pressure phase-equilibrium data were published between 2000 and 2004 is given. Vapor-liquid equilibria, liquid-liquid equilibria, vapor-liquid-liquid equilibria,solid-liquid equilibria, solid-vapor equilibria, solid-vapor-l...

  14. Computational fluid dynamics simulations of flow and concentration polarization in forward osmosis membrane systems

    DEFF Research Database (Denmark)

    Gruber, M.F.; Johnson, C.J.; Tang, C.Y.

    2011-01-01

    is inspired by previously published CFD models for pressure-driven systems and the general analytical theory for flux modeling in asymmetric membranes. Simulations reveal a non-negligible external concentration polarization on the porous support, even when accounting for high cross-flow velocity and slip...

  15. Combinatorial Optimization for Energy Saving in Nickel Industry Non-Newtonian Fluid Pumping System

    International Nuclear Information System (INIS)

    Hernández Ramírez, Gabriel; Legra Lobaina, Aristides; Columbié Navarro, Angel; Marcos Aníbal León Segovia

    2017-01-01

    In the present work a study of the influence of the rheological parameters of the lateritic hydromixtures with the energetic ones of the pumping systems that guarantee the productivity of nickel company 'Commander Pedro Sotto Alba' is carried out. From an experimental study and through an estimator, the rheological parameters are modeled as a function of the factors: temperature, solids content, chemical and granulometric composition. From an appropriate discretization of the model of the lateritic hydrometer pumping system and the application of a Discrete Combination Optimization Double Sequencing procedure, the operating parameters of this system were obtained, in order to guarantee a flow rate of 1600 m3 / h and one Adequate solids concentration. It is concluded that the use of a mathematical model that relates the rheological parameters of the lateritic pulp and the energy parameters of the pumping system, guarantee the metallurgical and energy efficiency in the acid leaching process with an average increase in production between 1000-1500 T Ni + Co / y and an energy saving of 30 MWh /year. (author)

  16. High frequency statistical energy analysis applied to fluid filled pipe systems

    NARCIS (Netherlands)

    Beek, P.J.G. van; Smeulers, J.P.M.

    2013-01-01

    In pipe systems, carrying gas with high velocities, broadband turbulent pulsations can be generated causing strong vibrations and fatigue failure, called Acoustic Fatigue. This occurs at valves with high pressure differences (i.e. chokes), relief valves and obstructions in the flow, such as sharp

  17. Modeling and investigation of refrigeration system performance with two-phase fluid injection in a scroll compressor

    Science.gov (United States)

    Gu, Rui

    Vapor compression cycles are widely used in heating, refrigerating and air-conditioning. A slight performance improvement in the components of a vapor compression cycle, such as the compressor, can play a significant role in saving energy use. However, the complexity and cost of these improvements can block their application in the market. Modifying the conventional cycle configuration can offer a less complex and less costly alternative approach. Economizing is a common modification for improving the performance of the refrigeration cycle, resulting in decreasing the work required to compress the gas per unit mass. Traditionally, economizing requires multi-stage compressors, the cost of which has restrained the scope for practical implementation. Compressors with injection ports, which can be used to inject economized refrigerant during the compression process, introduce new possibilities for economization with less cost. This work focuses on computationally investigating a refrigeration system performance with two-phase fluid injection, developing a better understanding of the impact of injected refrigerant quality on refrigeration system performance as well as evaluating the potential COP improvement that injection provides based on refrigeration system performance provided by Copeland.

  18. A haptic sensor-actor-system based on ultrasound elastography and electrorheological fluids for virtual reality applications in medicine.

    Science.gov (United States)

    Khaled, W; Ermert, H; Bruhns, O; Boese, H; Baumann, M; Monkman, G J; Egersdoerfer, S; Meier, A; Klein, D; Freimuth, H

    2003-01-01

    Mechanical properties of biological tissue represent important diagnostic information and are of histological relevance (hard lesions, "nodes" in organs: tumors; calcifications in vessels: arteriosclerosis). The problem is, that such information is usually obtained by digital palpation only, which is limited with respect to sensitivity. It requires intuitive assessment and does not allow quantitative documentation. A suitable sensor is required for quantitative detection of mechanical tissue properties. On the other hand, there is also some need for a realistic mechanical display of those tissue properties. Suitable actuator arrays with high spatial resolution and real-time capabilities are required operating in a haptic sensor actuator system with different applications. The sensor system uses real time ultrasonic elastography whereas the tactile actuator is based on electrorheological fluids. Due to their small size the actuator array elements have to be manufactured by micro-mechanical production methods. In order to supply the actuator elements with individual high voltages a sophisticated switching and control concept have been designed. This haptic system has the potential of inducing real time substantial forces, using a compact lightweight mechanism which can be applied to numerous areas including intraoperative navigation, telemedicine, teaching, space and telecommunication.

  19. Numerical Coupling and Simulation of Point-Mass System with the Turbulent Fluid Flow

    Science.gov (United States)

    Gao, Zheng

    A computational framework that combines the Eulerian description of the turbulence field with a Lagrangian point-mass ensemble is proposed in this dissertation. Depending on the Reynolds number, the turbulence field is simulated using Direct Numerical Simulation (DNS) or eddy viscosity model. In the meanwhile, the particle system, such as spring-mass system and cloud droplets, are modeled using the ordinary differential system, which is stiff and hence poses a challenge to the stability of the entire system. This computational framework is applied to the numerical study of parachute deceleration and cloud microphysics. These two distinct problems can be uniformly modeled with Partial Differential Equations (PDEs) and Ordinary Differential Equations (ODEs), and numerically solved in the same framework. For the parachute simulation, a novel porosity model is proposed to simulate the porous effects of the parachute canopy. This model is easy to implement with the projection method and is able to reproduce Darcy's law observed in the experiment. Moreover, the impacts of using different versions of k-epsilon turbulence model in the parachute simulation have been investigated and conclude that the standard and Re-Normalisation Group (RNG) model may overestimate the turbulence effects when Reynolds number is small while the Realizable model has a consistent performance with both large and small Reynolds number. For another application, cloud microphysics, the cloud entrainment-mixing problem is studied in the same numerical framework. Three sets of DNS are carried out with both decaying and forced turbulence. The numerical result suggests a new way parameterize the cloud mixing degree using the dynamical measures. The numerical experiments also verify the negative relationship between the droplets number concentration and the vorticity field. The results imply that the gravity has fewer impacts on the forced turbulence than the decaying turbulence. In summary, the

  20. Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain.

    Science.gov (United States)

    Taoka, Toshiaki; Naganawa, Shinji

    2018-04-10

    After Kanda's first report in 2014 on gadolinium (Gd) deposition in brain tissue, a considerable number of studies have investigated the explanation for the observation. Gd deposition in brain tissue after repeated administration of gadolinium-based contrast medium (GBCM) has been histologically proven, and chelate stability has been shown to affect the deposition. However, the mechanism for this deposition has not been fully elucidated. Recently, a hypothesis was introduced that involves the 'glymphatic system', which is a coined word that combines 'gl' for glia cell and 'lymphatic' system. According to this hypothesis, the perivascular space functions as a conduit for cerebrospinal fluid to flow into the brain parenchyma. The perivascular space around the arteries allows cerebrospinal fluid to enter the interstitial space of the brain tissue through water channels controlled by aquaporin 4. The cerebrospinal fluid entering the interstitial space clears waste proteins from the tissue. It then flows into the perivascular space around the vein and is discharged outside the brain. In addition to the hypothesis regarding the glymphatic system, some reports have described that after GBCM administration, some of the GBCM distributes through systemic blood circulation and remains in other compartments including the cerebrospinal fluid. It is thought that the GBCM distributed into the cerebrospinal fluid cavity via the glymphatic system may remain in brain tissue for a longer duration compared to the GBCM in systemic circulation. Glymphatic system may of course act as a clearance system for GBCM from brain tissue. Based on these findings, the mechanism for Gd deposition in the brain will be discussed in this review. The authors speculate that the glymphatic system may be the major contributory factor to the deposition and clearance of gadolinium in brain tissue.