WorldWideScience

Sample records for fluid status control

  1. Fluid status telemedicine alerts for heart failure: a randomized controlled trial.

    Science.gov (United States)

    Böhm, Michael; Drexler, Helmut; Oswald, Hanno; Rybak, Karin; Bosch, Ralph; Butter, Christian; Klein, Gunnar; Gerritse, Bart; Monteiro, Joao; Israel, Carsten; Bimmel, Dieter; Käab, Stefan; Huegl, Burkhard; Brachmann, Johannes

    2016-11-01

    Hospital admissions are frequently preceded by increased pulmonary congestion in heart failure (HF) patients. This study evaluated whether early automated fluid status alert notification via telemedicine improves outcome in HF patients. Patients recently implanted with an implantable cardioverter defibrillator (ICD) with or without cardiac resynchronization therapy were eligible if one of three conditions was met: prior HF hospitalization, recent diuretic treatment, or recent brain natriuretic peptide increase. Eligible patients were randomized (1:1) to have fluid status alerts automatically transmitted as inaudible text message alerts to the responsible physician or to receive standard care (no alerts). In the intervention arm, following a telemedicine alert, a protocol-specified algorithm with remote review of device data and telephone contact was prescribed to assess symptoms and initiate treatment. The primary endpoint was a composite of all-cause death and cardiovascular hospitalization. We followed 1002 patients for an average of 1.9 years. The primary endpoint occurred in 227 patients (45.0%) in the intervention arm and 239 patients (48.1%) in the control arm [hazard ratio, HR, 0.87; 95% confidence interval (CI), 0.72-1.04; P = 0.13]. There were 59 (11.7%) deaths in the intervention arm and 63 (12.7%) in the control arm (HR, 0.89; 95% CI, 0.62-1.28; P = 0.52). Twenty-four per cent of alerts were not transmitted and 30% were followed by a medical intervention. Among ICD patients with advanced HF, fluid status telemedicine alerts did not significantly improve outcomes. Adherence to treatment protocols by physicians and patients might be challenge for further developments in the telemedicine field. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.

  2. Cerebrospinal fluid tau proteins in status epilepticus.

    Science.gov (United States)

    Monti, Giulia; Tondelli, Manuela; Giovannini, Giada; Bedin, Roberta; Nichelli, Paolo F; Trenti, Tommaso; Meletti, Stefano; Chiari, Annalisa

    2015-08-01

    Tau protein is a phosphorylated microtubule-associated protein, principally localized at neuronal level in the central nervous system (CNS). Tau levels in the cerebrospinal fluid (CSF) are considered to index both axonal and neuronal damage. To date, however, no study has specifically evaluated the CSF levels of tau proteins in patients with status epilepticus (SE). We evaluated these established biomarkers of neuronal damage in patients with SE who received a lumbar puncture during SE between 2007 and 2014. Status epilepticus cases due to acute structural brain damage, including CNS infection, were excluded. Clinical, biological, therapeutic, and follow-up data were collected. Group comparison between patients stratified according to SE response to antiepileptic drugs (AEDs), disability, and epilepsy outcomes were performed. Twenty-eight patients were considered for the analyses (mean age 56 years): 14 patients had abnormally high CSF t-tau level, six patients had abnormally high CSF p-tau level, and only three patients had abnormally low Aβ1-42 level. Cerebrospinal fluid t-tau value was higher in patients who developed a refractory SE compared to patients with seizures controlled by AED. Cerebrospinal fluid t-tau values were positively correlated with SE duration and were higher in patients treated with propofol anesthesia compared to patients that had not received this treatment. Patients with higher CSF t-tau had higher risk of developing disability (OR = 32.5, p = 0.004) and chronic epilepsy (OR = 12; p = 0.016) in comparison with patients with lower CSF t-tau level. Our results suggest that CSF t-tau level might be proposed as a biomarker of SE severity and prognosis. Prospective studies are needed to evaluate the effects of propofol on tau pathology in this setting. This article is part of a Special Issue entitled "Status Epilepticus".

  3. Fluid/Gas Process Controller

    Science.gov (United States)

    Ramos, Sergio

    1989-01-01

    Fluid/gas controller, or "Super Burper", developed to obtain precise fill quantities of working fluid and noncondensable gas in heat pipe by incorporating detachable external reservoir into system during processing stage. Heat pipe filled with precise quantities of working fluid and noncondensable gas, and procedure controlled accurately. Application of device best suited for high-quality, high performance heat pipes. Device successfully implemented with various types of heat pipes, including vapor chambers, thermal diodes, large space radiators, and sideflows.

  4. Hydration Status of Patients Dialyzed with Biocompatible Peritoneal Dialysis Fluids.

    Science.gov (United States)

    Lichodziejewska-Niemierko, Monika; Chmielewski, Michał; Dudziak, Maria; Ryta, Alicja; Rutkowski, Bolesław

    2016-01-01

    ♦ Biocompatible fluids for peritoneal dialysis (PD) have been introduced to improve dialysis and patient outcome in end-stage renal disease. However, their impact on hydration status (HS), residual renal function (RRF), and dialysis adequacy has been a matter of debate. The aim of the study was to evaluate the influence of a biocompatible dialysis fluid on the HS of prevalent PD patients. ♦ The study population consisted of 18 prevalent PD subjects, treated with standard dialysis fluids. At baseline, 9 patients were switched to a biocompatible solution, low in glucose degradation products (GDPs) (Balance; Fresenius Medical Care, Bad Homburg, Germany). Hydration status was assessed through clinical evaluation, laboratory parameters, echocardiography, and bioimpedance spectroscopy over a 24-month observation period. ♦ During the study period, urine volume decreased similarly in both groups. At the end of the evaluation, there were also no differences in clinical (body weight, edema, blood pressure), laboratory (N-terminal pro-brain natriuretic peptide, NTproBNP), or echocardiography determinants of HS. However, dialysis ultrafiltration decreased in the low-GDP group and, at the end of the study, equaled 929 ± 404 mL, compared with 1,317 ± 363 mL in the standard-fluid subjects (p = 0.06). Hydration status assessed by bioimpedance spectroscopy was +3.64 ± 2.08 L in the low-GDP patients and +1.47 ± 1.61 L in the controls (p = 0.03). ♦ The use of a low-GDP biocompatible dialysis fluid was associated with a tendency to overhydration, probably due to diminished ultrafiltration in prevalent PD patients. Copyright © 2016 International Society for Peritoneal Dialysis.

  5. Supercritical Fluid Extraction: Present Status and Prospects

    Energy Technology Data Exchange (ETDEWEB)

    King, J. W.

    2002-07-01

    Supercritical extraction (SFE), using primarily environmentally-benign carbon dioxide (CO{sub 2}) as the extraction agent, is reviewed with respect to its present status and future use. SFE was developed for analytical application in the mid 1980's in response to the desire to reduce the use of organic solvents in the laboratory environment and is becoming a standard method for the preparation and analysis of lipid-containing sample matrices. Currently, analytical SFE is predominately practiced in the off-line mode, using both sequential and parallel extraction modes. Depending on the instrumental configuration, the preparation of up to 24 samples can be accomplished on one instrument on a daily basis. Several other benefits can be achieved using SFE, such as the processing of thermally-sensitive analytes and rapid analyte extraction kinetics relative to extraction with liquid solvents. Examples are provided not only of the analytical SFE of oils and fats, but of volatile solutes from an array of sample types. Finally, the relevance of analytical SFE to processing with supercritical fluids (SFs) is documented using examples from our own research involving a combinatorial approach to optimising processing conditions. (Author) 70 refs.

  6. [Arterial pressure curve and fluid status].

    Science.gov (United States)

    Pestel, G; Fukui, K

    2009-04-01

    Fluid optimization is a major contributor to improved outcome in patients. Unfortunately, anesthesiologists are often in doubt whether an additional fluid bolus will improve the hemodynamics of the patient or not as excess fluid may even jeopardize the condition. This article discusses physiological concepts of liberal versus restrictive fluid management followed by a discussion on the respective capabilities of various monitors to predict fluid responsiveness. The parameter difference in pulse pressure (dPP), derived from heart-lung interaction in mechanically ventilated patients is discussed in detail. The dPP cutoff value of 13% to predict fluid responsiveness is presented together with several assessment techniques of dPP. Finally, confounding variables on dPP measurements, such as ventilation parameters, pneumoperitoneum and use of norepinephrine are also mentioned.

  7. The Status of Fluid Mechanics in Bioengineering Curricula.

    Science.gov (United States)

    Miller, Gerald E.; Hyman, William A.

    1981-01-01

    Describes the status of fluid mechanics courses in bioengineering curricula. A survey of institutions offering bioengineering degrees indicates that over half do not require fluid mechanics courses. Suggests increasing number of mechanics courses to increase the quality of bioengineering students and to prepare students for graduate work and more…

  8. The Status of Fluid Mechanics in Bioengineering Curricula.

    Science.gov (United States)

    Miller, Gerald E.; Hyman, William A.

    1981-01-01

    Describes the status of fluid mechanics courses in bioengineering curricula. A survey of institutions offering bioengineering degrees indicates that over half do not require fluid mechanics courses. Suggests increasing number of mechanics courses to increase the quality of bioengineering students and to prepare students for graduate work and more…

  9. Supercritical fluid extraction: Present status and prospects

    Directory of Open Access Journals (Sweden)

    King, Jerry W.

    2002-03-01

    Full Text Available Supercritical extraction (SFE, using primarily environmentally-benign carbon dioxide (CO2 as the extracting agent, is reviewed with respect to its present status and future use. SFE was developed for analytical application in the mid 1980’s in response to the desire to reduce the use of organic solvents in the laboratory environment and is becoming a standard method for the preparation and analysis of lipid-containing sample matrices. Currently, analytical SFE is predominately practiced in the off-line mode, using both sequential and parallel extraction modes. Depending on the instrumental configuration, the preparation of up to 24 samples can be accomplished on one instrument on a daily basis. Several other benefits can be achieved using SFE, such as the processing of thermally-sensitive analytes and rapid analyte extraction kinetics relative to extraction with liquid solvents. Examples are provided not only of the analytical SFE of oils and fats, but of volatile solutes from an array of sample types. Finally, the relevance of analytical SFE to processing with supercritical fluids (SFs is documented using examples from our own research involving a combinatorial approach to optimising processing conditions.Este artículo revisa el presente y el uso futuro de la extracción con fluidos supercríticos (SFE, principalmente dióxido de carbono (CO2 benigno para el ambiente. La extracción con fluidos supercríticos se desarrolló como aplicación analítica a mediados de los años 80 como respuesta al deseo de reducir el uso de disolventes orgánicos en el ambiente del laboratorio, y se está convirtiendo en un método estándar con respecto a la preparación y análisis de muestras conteniendo lípidos. Actualmente, la analítica de SFE es predominantemente aplicada en modo “off-line”, usando modos de extracción secuenciales y paralelos. Dependiendo de la configuración de la instrumentación, se pueden llegar a preparar diariamente

  10. Temperature controller for a fluid cooled garment

    Science.gov (United States)

    Chambers, A. B.; Blackaby, J. R.; Billingham, J. (Inventor)

    1973-01-01

    An automatic controller for controlling the inlet temperature of the coolant to a fluid cooled garment without requiring skin sensors is described. Temperature is controlled by the wearer's evaporative water loss rate.

  11. The Status of Computational Fluid Dynamics

    DEFF Research Database (Denmark)

    Nielsen, Peter Vilhelm; Liu, Li; Peng, Lei;

    2016-01-01

    This article presents a short discussion of the development of CFD by showing two examples: an early case and a recent study on the cross-infection risks from a person's exhalation of particles. The article will also address the use of benchmark tests as a quality control of CFD....

  12. Fluid control structures in microfluidic devices

    Energy Technology Data Exchange (ETDEWEB)

    Mathies, Richard A.; Grover, William H.; Skelley, Alison; Lagally, Eric; Liu, Chung N.

    2017-05-09

    Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.

  13. Control of a catalytic fluid cracker

    Energy Technology Data Exchange (ETDEWEB)

    Arbel, A.; Huang, Z.; Rinard, I.; Shinnar, R.

    1993-12-13

    Control offers an important tool for savings in refineries, mainly by integration of process models into on-line control. This paper is part of a research effort to better understand problems of partial control; control of a Fluid Catalytic Cracker (FCC) is used as example. Goal is to understand better the control problems of an FCC in context of model based control of a refinery, and to understand the general problem of designing partial control systems.

  14. Neural Control Mechanisms and Body Fluid Homeostasis

    Science.gov (United States)

    Johnson, Alan Kim

    1998-01-01

    The goal of the proposed research was to study the nature of afferent signals to the brain that reflect the status of body fluid balance and to investigate the central neural mechanisms that process this information for the activation of response systems which restore body fluid homeostasis. That is, in the face of loss of fluids from intracellular or extracellular fluid compartments, animals seek and ingest water and ionic solutions (particularly Na(+) solutions) to restore the intracellular and extracellular spaces. Over recent years, our laboratory has generated a substantial body of information indicating that: (1) a fall in systemic arterial pressure facilitates the ingestion of rehydrating solutions and (2) that the actions of brain amine systems (e.g., norepinephrine; serotonin) are critical for precise correction of fluid losses. Because both acute and chronic dehydration are associated with physiological stresses, such as exercise and sustained exposure to microgravity, the present research will aid in achieving a better understanding of how vital information is handled by the nervous system for maintenance of the body's fluid matrix which is critical for health and well-being.

  15. Offshore Structural Control Considering Fluid Structure Interaction

    Institute of Scientific and Technical Information of China (English)

    Ju Myung KIM; Dong Hyawn KIM; Gyu Won LEE

    2006-01-01

    Tuned Mass Damper (TMD) was applied to an offshore structure to control ocean wave-induced vibration. In the analysis of the dynamic response of the offshore structure, fluid-structure interaction is considered and the errors, which occur in the linearization of the interaction, are investigated. For the investigation of the performance of TMD in controlling the vibration, both regular waves with different periods and irregular waves with different significant wave heights are used. Based on the numerical analysis it is concluded that the fluid-structure interaction should be considered in the evaluation of the capability of TMD in vibration control of offshore structures.

  16. Monitoring fluid status at the outpatient level: the need for more precision.

    LENUS (Irish Health Repository)

    McDonald, Ken

    2012-02-01

    Accurate determination of fluid status in patients with heart failure is a critical aspect of care of this population. Early detection of emerging fluid overload would allow for prompt intervention, potentially aborting clinical deterioration and avoiding hospitalization. While many strategies are available to determine fluid status of patients, all areas are compromised by less-than-optimal sensitivity and specificity. Recent work on the role of bioimpedance as a means of assessing a patient\\'s fluid status indicates that this parameter may have a role in monitoring patients with heart failure. This article reviews present techniques available for assessment of fluid status and focuses on the additional information provided by bioimpedance assessment.

  17. Monitoring fluid status at the outpatient level: the need for more precision.

    LENUS (Irish Health Repository)

    McDonald, Ken

    2010-07-01

    Accurate determination of fluid status in patients with heart failure is a critical aspect of care of this population. Early detection of emerging fluid overload would allow for prompt intervention, potentially aborting clinical deterioration and avoiding hospitalization. While many strategies are available to determine fluid status of patients, all areas are compromised by less-than-optimal sensitivity and specificity. Recent work on the role of bioimpedance as a means of assessing a patient\\'s fluid status indicates that this parameter may have a role in monitoring patients with heart failure. This article reviews present techniques available for assessment of fluid status and focuses on the additional information provided by bioimpedance assessment.

  18. Turbomachinery Fluid Mechanics and Control

    Science.gov (United States)

    2010-01-01

    STEVEN L. PUTERBAUGH WILLIAM W. COPENHAVER Compressor Aero Research Lab...report. Bailie, S.T., Ng, W., Wicks, S., and Copenhaver , W.W., “Effects of Flow Control on Forced Response and Performance of a Transonic Compressor...34, 44th AIAA Aerospace Sciences Meeting and Exhibit, Reno, NV, 2006, AIAA Paper No. 2006-0417. Car, D., Kuprowicz, N.J., Estevadeordal, J., Zha, G

  19. Fluid control in microfluidic devices using a fluid conveyance extension and an absorbent microfluidic flow modulator.

    Science.gov (United States)

    Yuen, Po Ki

    2013-05-07

    This article presents a simple method for controlling fluid in microfluidic devices without the need for valves or pumps. A fluid conveyance extension is fluidly coupled to the enclosed outlet chamber of a microfluidic device. After a fluid is introduced into the microfluidic device and saturates the fluid conveyance extension, a fluid flow in the microfluidic device is generated by contacting an absorbent microfluidic flow modulator with the fluid conveyance extension to absorb the fluid from the fluid conveyance extension through capillary action. Since the fluid in the microfluidic device is fluidly coupled with the fluid conveyance extension and the fluid conveyance extension is fluidly coupled with the absorbent microfluidic flow modulator, the absorption rate of the absorbent microfluidic flow modulator, which is the rate at which the absorbent microfluidic flow modulator absorbs fluid, matches the fluid flow rate in the microfluidic device. Thus, the fluid flow rate in the microfluidic device is set by the absorption rate of the absorbent microfluidic flow modulator. Sheath flow and fluid switching applications are demonstrated using this simple fluid control method without the need for valves or pumps. Also, the ability to control the fluid flow rate in the microfluidic device is demonstrated using absorbent microfluidic flow modulators with various absorbent characteristics and dimensions.

  20. 液压管路流固耦合振动机理及控制研究现状与发展%Research Status and Trends on Fluid-structure Interaction Vibration Mechanism and Control of Hydraulic Pipeline

    Institute of Scientific and Technical Information of China (English)

    权凌霄; 孔祥东; 俞滨; 白欢欢

    2015-01-01

    液压管路系统由于存在多物理场、多尺度及流固耦合非线性等特性,因此其振动特性复杂,且危害很大。又由于工业生产的需求,液压系统正逐步向高压高速和高功重比方向发展,又使得液压管路振动的产生和传播机理变得更为复杂。因此有必要对液压管路的振动机理和控制方法及其研究现状进行总结和分析。阐述液压管路振动的危害性和复杂性,并结合近十年来国内外专家学者对于液压管路振动模型的研究内容,在对考虑多场、多尺度及流固耦合因素影响的液压管路振动机理进行总结的基础上,对液压管路流固耦合线性化动力学模型和非线性振动模型的研究成果进行分析,并对液压管路被动、主动及半主动振动控制的研究进展及研究成果进行评述,在此基础上提出今后液压管路系统流固耦合振动机理及振动控制研究的发展趋势。%Because of the effects of multi-physics, multi-scale and fluid-structure interaction(FSI), the vibration characteristics of the hydraulic pipeline system is not only complex, but also harmful. Due to the demand of the industrial production, the hydraulic system is gradually to develop in the direction of high pressure, high speed and high power ratio, which makes the production and propagation mechanism of hydraulic pipeline vibration become more complex. So it is necessary to summary and analyze the research status of the vibration mechanism and control method of hydraulic pipeline. Harmfulness and complexity of hydraulic pipeline vibration are expounded. Combined with the research on hydraulic pipeline vibration and dynamic model which the domestic and abroad experts are committed to in last ten years, hydraulic piping vibration mechanism, in which effects of multi-physics, multi-scale and FSI is taken into account, is summarized. On this basis, some research such as hydraulic pipeline of FSI linear

  1. Controlling Wavebreaking in a Viscous Fluid Conduit

    Science.gov (United States)

    Anderson, Dalton; Maiden, Michelle; Hoefer, Mark

    2015-11-01

    This poster will present a new technique in the experimental investigation of dispersive hydrodynamics. In shallow water flows, internal ocean waves, superfluids, and optical media, wave breaking can be resolved by a dispersive shock wave (DSW). In this work, an experimental method to control the location of DSW formation (gradient catastrophe) is explained. The central idea is to convert an initial value problem (Riemann problem) into an equivalent boundary value problem. The system to which this technique is applied is a fluid conduit resulting from high viscosity contrast between a buoyant interior and heavier exterior fluid. The conduit cross-sectional area is modeled by a nonlinear, conservative, dispersive, third order partial differential equation. Using this model, the aim is to predict the breaking location of a DSW by controlling one boundary condition. An analytical expression for this boundary condition is derived by solving the dispersionless equation backward in time from the desired step via the method of characteristics. This is used in experiment to generate an injection rate profile for a high precision piston pump. This translates to the desired conduit shape. Varying the jump height and desired breaking location indicates good control of DSW formation. This result can be improved by deriving a conduit profile by numerical simulation of the full model equation. Controlling the breaking location of a DSW allows for the investigation of dynamics independent of the boundary. Support provided by NSF CAREER DMS-1255422 , NSF EXTREEMS.

  2. Intelligently Controllable Walker with Magnetorheological Fluid Brake

    Science.gov (United States)

    Kikuchi, Takehito; Tanida, Sosuke; Tanaka, Toshimasa; Kobayashi, Keigo; Mitobe, Kazuhisa

    Caster walkers are supporting frames with casters and wheels. These tools are regularly utilized as life support tools or walking rehabilitation tools in hospitals, nursing homes and individual residences. Users of the walkers can easily move it thanks to its wheels and casters. However falling accidents often happen when it moves without users. The falling accident is very serious problem and one of leading causes of secondary injuries. In the other case, it is hard to move to desired directions if users have imbalance in their motor functions or sensory functions, e.g., hemiplegic patients. To improve safeness and operability of the walkers, we installed compact MR fluid brakes on the wheels and controlled walking speed and direction of the walker. We named this intelligently controllable walker, “i-Walker” and discussed on the control methods and experimental results in this paper. Preliminary trials for direction control of the first-generation of the i-Walker (i-Walker1) are presented. On the basis of the results, we improved the control method and hardware of the i-Walker1, and developed the second-generation (i-Walker2). System description and experimental results of the i-Walker2 are also described. The i-Walker2 has better operability and lower energy consumption than that of the i-Walker1. The line-tracing controller of the i-Walker2 well controls human motions during walking experiments on the target straight line.

  3. Antioxidant Vitamin Status in the Serum and Amniotic Fluid of Women with Premature Rupture of the Fetal Membranes.

    Science.gov (United States)

    Barrett, Bridget M.

    The purpose of this study was to examine the status of antioxidant vitamins in women with premature rupture of the fetal membranes. Specimens of blood and amniotic fluid were obtained from 80 pregnant subjects included both smokers and non-smokers during the third trimester. The concentrations of ascorbic acid (ASA), beta -carotene, retinol and alpha -tocopherol in serum and amniotic fluid were determined. The experimental group consisted of those subjects with PROM while the control subjects were those with normal pregnancy. No statistical differences were found between the PROM and control groups in retinol and vitamin E concentrations in amniotic fluid and serum. Serum ASA concentrations of PROM subjects were not different from controls, but the PROM subjects had significantly lower amniotic fluid ASA concentrations. However, in a study with fewer subjects a lower serum ASA concentration in the PROM subjects was observed. The ratio of amniotic fluid ASA concentration to ASA serum concentration was significantly lower in PROM patients than in controls in both studies. This suggests that low levels of ASA in the amniotic fluid, but not in serum is better associated with PROM. A low amniotic fluid concentration of ASA may reflect an inefficient transfer and/or increased fetal utilization. Alterations in ASA concentration in the amniotic fluid may affect the integrity of the chorioamnion leading to PROM. beta -Carotene was not found in the amniotic fluid. Serum beta-carotene levels were significantly lower in the PROM group compared to the control group. Low concentrations of beta-carotene in maternal serum in smokers not only associated with poor maternal outcome (PROM) but also compromised the fetal outcome (decreased birth weight). Maintenance of adequate serum beta-carotene concentration and amniotic fluid ASA in smokers may result in better maternal and fetal outcome. This study demonstrated that nutrition is an important factor in the prevention of PROM.

  4. Controlled differential pressure system for an enhanced fluid blending apparatus

    Science.gov (United States)

    Hallman, Jr., Russell Louis

    2009-02-24

    A system and method for producing a controlled blend of two or more fluids. Thermally-induced permeation through a permeable tube is used to mix a first fluid from outside the tube with a second fluid flowing through the tube. Mixture ratios may be controlled by adjusting the temperature of the first fluid or by adjusting the pressure drop through the permeable tube. The combination of a back pressure control valve and a differential regulator is used to control the output pressure of the blended fluid. The combination of the back pressure control valve and differential regulator provides superior flow control of the second dry gas. A valve manifold system may be used to mix multiple fluids, and to adjust the volume of blended fluid produced, and to further modify the mixture ratio.

  5. Proliferation Control Regimes: Background and Status

    Science.gov (United States)

    2012-10-25

    1984 OPCW U.N. Conference on Disarmament EAA, 1979 AECA, 1976 Biological Weapons Anti- Terrorism Act Chem- Bio Weapons Control Warfare...Deauville, France. They reaffirmed the goals set out at the 2010 Summit for future Global Partnership activities: nuclear and radiological security, bio ... herbicides and riot control agents. Proliferation Control Regimes: Background and Status Congressional Research Service 44 Author Contact

  6. Controlling and minimizing fingering instabilities in non-Newtonian fluids.

    Science.gov (United States)

    Fontana, João V; Dias, Eduardo O; Miranda, José A

    2014-01-01

    The development of the viscous fingering instability in Hele-Shaw cells has great practical and scientific importance. Recently, researchers have proposed different strategies to control the number of interfacial fingering structures, or to minimize as much as possible the amplitude of interfacial disturbances. Most existing studies address the situation in which an inviscid fluid displaces a viscous Newtonian fluid. In this work, we report on controlling and minimizing protocols considering the situation in which the displaced fluid is a non-Newtonian, power-law fluid. The necessary changes on the controlling schemes due to the shear-thinning and shear thickening nature of the displaced fluid are calculated analytically and discussed.

  7. Comparison of Wired and Wireless Bio-Electrical Impedance Fluid Status Monitoring Devices and Validation to Body Mass and Urine Specific Gravity Changes Following Mild Dehydration

    Science.gov (United States)

    2008-01-18

    status assessment method, ZOE2, is FDA approved for fluid status monitoring. The ZOE2 measures thoracic bio -electrical impedance. A new wireless version...impedance as a valid measure of hydration status in clinical or controlled settings. However, there is speculation as to the utility of bio -electrical...no significant differences were detected between pre- to post-practice for the ZOE2 or ZOEW device. Bio -electrical impedance, as measured by the ZOEW

  8. Boundary control of fluid flow through porous media

    DEFF Research Database (Denmark)

    Hasan, Agus; Foss, Bjarne; Sagatun, Svein Ivar

    2010-01-01

    The flow of fluids through porous media can be described by the Boussinesq’s equation with mixed boundary conditions; a Neumann’s boundary condition and a nonlinear boundary condition. The nonlinear boundary condition provides a means to control the fluid flow through porous media. In this paper,......, some stabilizing controllers are constructed for various cases using Lyapunov design....

  9. Structural controls on fluid escape from the subduction interface

    Science.gov (United States)

    Reynard, Bruno; Tauzin, Benoit; Bodin, Thomas; Perrillat, Jean-Philippe; Debayle, Eric

    2017-04-01

    Seismic activity and non-volcanic tremors are often associated with fluid circulation resulting from the dehydration of subducting plates. Tremors in the overriding continental crust of several subduction zones suggest fluid circulation at shallower depths, but potential fluid pathways are still poorly documented. Fluids are also released at different depths in hot and cold subduction zones, which may result in different schemes of fluid escape. We document potential fluid pathways in Cascadia, one of the hottest subduction zone, using receiver function analysis. We provide evidence for a seismic discontinuity near 15 km depth in the crust of the overriding North American plate. This interface is segmented, and its interruptions are spatially correlated with conductive regions of the forearc and shallow swarms of seismicity and non-volcanic tremors. The comparison of seismological and electrical conductivity profiles suggests that fluid escape is controlled by fault zones between blocks of accreted terranes in the overriding plate. These zones constitute fluid escape routes that may influence the seismic cycle by releasing fluid pressure from the megathrust. Results on Cascadia are compared to fluid escape routes suggested by former geophysical observations in NE Japan, one of the coldest subduction zones. Links between fluid escape, permeability and fluid-rock reactions at or above the plate interface are discussed.

  10. Fluid flow control with transformation media

    CERN Document Server

    Urzhumov, Yaroslav A

    2011-01-01

    We introduce a new concept for the manipulation of fluid flow around three-dimensional bodies. Inspired by transformation optics, the concept is based on a mathematical idea of coordinate transformations, and physically implemented with anisotropic porous media permeable to the flow of fluids. In two different situations - for an impermeable object situated either in a free-flowing fluid or in a fluid-filled porous medium - we show that the object can be coated with a properly chosen inhomogeneous, anisotropic permeable medium, such as to preserve the streamlines of flow and the pressure distribution that would have existed in the absence of the object. The proposed fluid flow cloak completely eliminates any disturbance of the flow by the object, including the downstream wake. Consequently, the structure helps prevent the onset of turbulence by keeping the flow laminar even above the typical critical Reynolds number for the object of the same shape and size. The cloak also cancels the viscous drag force. This...

  11. Parallel Computational Fluid Dynamics: Current Status and Future Requirements

    Science.gov (United States)

    Simon, Horst D.; VanDalsem, William R.; Dagum, Leonardo; Kutler, Paul (Technical Monitor)

    1994-01-01

    One or the key objectives of the Applied Research Branch in the Numerical Aerodynamic Simulation (NAS) Systems Division at NASA Allies Research Center is the accelerated introduction of highly parallel machines into a full operational environment. In this report we discuss the performance results obtained from the implementation of some computational fluid dynamics (CFD) applications on the Connection Machine CM-2 and the Intel iPSC/860. We summarize some of the experiences made so far with the parallel testbed machines at the NAS Applied Research Branch. Then we discuss the long term computational requirements for accomplishing some of the grand challenge problems in computational aerosciences. We argue that only massively parallel machines will be able to meet these grand challenge requirements, and we outline the computer science and algorithm research challenges ahead.

  12. Fluid damping clearance in a control valve of injector

    Institute of Scientific and Technical Information of China (English)

    ZHANG Jianming; ZHANG Weigang; YANG Bing; WANG Yawei

    2007-01-01

    A force model of a control valve of injector is set up, and the changes of the fluid damping clearance are investigated on the basis of the results of the computational fluid dynamics (CFD) and the experiments of control valve of injector. Results indicate that a damping clearance of 0.02-0.03 mm between the poppet and the valve guide is the most sufficient to dampen any excessive control valve poppet bouncing.

  13. Linking rigid multibody systems via controllable thin fluid films

    DEFF Research Database (Denmark)

    Estupinan, Edgar Alberto; Santos, Ilmar

    2009-01-01

    , this paper gives a theoretical contribution to the combined fields of fluid–structure interaction and vibration control. The methodology is applied to a reciprocating linear compressor, where the dynamics of the mechanical components are described with help of multibody dynamics. The crank is linked...... of the journal orbits, maximum fluid film pressure and minimum fluid film thickness....

  14. Endurance Cyclist Fluid Intake, Hydration Status, Thirst, and Thermal Sensations: Gender Differences.

    Science.gov (United States)

    Armstrong, Lawrence E; Johnson, Evan C; McKenzie, Amy L; Ellis, Lindsay A; Williamson, Keith H

    2016-04-01

    This field investigation assessed differences (e.g., drinking behavior, hydration status, perceptual ratings) between female and male endurance cyclists who completed a 164-km event in a hot environment (35 °C mean dry bulb) to inform rehydration recommendations for athletes. Three years of data were pooled to create 2 groups of cyclists: women (n = 15) and men (n = 88). Women were significantly smaller (p < .001) than men in height (166 ± 5 vs. 179 ± 7 cm), body mass (64.6 ± 7.3 vs. 86.4 ± 12.3 kg), and body mass index (BMI; 23.3 ± 1.8 vs. 26.9 ± 3.4) and had lower preevent urinary indices of hydration status, but were similar to men in age (43 ± 7 years vs. 44 ± 9 years) and exercise time (7.77 ± 1.24 hr vs. 7.23 ± 1.75 hr). During the 164-km ride, women lost less body mass (-0.7 ± 1.0 vs. -1.7 ± 1.5 kg; -1.1 ± 1.6% vs. -1.9 ± 1.8% of body weight; p < .005) and consumed less fluid than men (4.80 ± 1.28 L vs. 5.59 ± 2.13 L; p < .005). Women consumed a similar volume of fluid as men, relative to body mass (milliliters/kilogram). To control for performance and anthropomorphic characteristics, 15 women were pair-matched with 15 men on the basis of exercise time on the course and BMI; urine-specific gravity, urine color, and body mass change (kilograms and percentage) were different (p < .05) in 4 of 6 comparisons. No gender differences were observed for ratings of thirst, thermal sensation, or perceived exertion. In conclusion, differences in relative fluid volume consumed and hydration indices suggest that professional sports medicine organizations should consider gender and individualized drinking plans when formulating pronouncements regarding rehydration during exercise.

  15. Spinal Fluid Lactate Dehydrogenase Level Differentiates between Structural and Metabolic Etiologies of Altered Mental Status in Children

    Directory of Open Access Journals (Sweden)

    Nahid KHOSROSHAHI

    2015-01-01

    Full Text Available How to Cite This Article: Khosroshahi N, Alizadeh P, Khosravi M, Salamati P, Kamrani K. Spinal Fluid Lactate Dehydrogenase Level Differentiates between Structural and Metabolic Etiologies of Altered Mental Status in Children. Iran J Child Neurol. 2015 Winter;9(1:31-36.AbstractObjectiveAltered mental status is a common cause of intensive care unit admission inchildren. Differentiating structural causes of altered mental status from metabolic etiologies is of utmost importance in diagnostic approach and management of the patients. Among many biomarkers proposed to help stratifying patients with altered mental status, spinal fluid lactate dehydrogenase appears to be the most promising biomarker to predict cellular necrosis.Materials & MethodsIn this cross sectional study we measured spinal fluid level of lactatedehydrogenase in children 2 months to 12 years of age admitted to a single center intensive care unit over one year. Spinal fluid level of lactate dehydrogenase in 40 pediatric cases of febrile seizure was also determined as the control group.ResultsThe study group included 35 boys (58.3% and 25 girls (41.7%. Their meanage was 2.7+/-3 years and their mean spinal fluid lactate dehydrogenase levelwas 613.8+/-190.4 units/liter. The control group included 24 boys (55.8% and19 girls (44.2%. Their mean age was 1.3+/-1.2 years and their mean spinalfluid lactate dehydrogenase level was 18.9+/-7.5 units/liter. The mean spinalfluid lactate dehydrogenase level in children with abnormal head CT scan was246.3+/-351.5 units/liter compared to 164.5+/-705.7 in those with normal CTscan of the head (p=0.001.ConclusionSpinal fluid lactate dehydrogenase level is useful in differentiating structural andmetabolic causes of altered mental status in children. ReferencesFesk SK. Coma and confusional states: emergency diagnosis and management. Neurol Clin 1998; 16: 237- 56.Cucchiara BL, Kanser SE, Wolk DA, et al. Early impairment in consciousness Predicts

  16. The SLC control system - status and development

    Energy Technology Data Exchange (ETDEWEB)

    Phinney, N.; Shoaee, H.

    1987-03-01

    The SLC control system is installed and operational in the full SLC through the Linac, Damping Rings, Positron Source, Arcs and Final Focus. The system now includes a host VAX 11/785, a development VAX 11/780, 4 VAX workstations, a distributed network of 70 microprocessors, and about 270 Camac crates with more than 4000 modules. The micros are used for control and monitoring of the hardware, for pulse-to-pulse feedback, and for consoles (COWs). High level model-driven host software provides a variety of tools for beam setup, optimization, diagnosis, and stabilization. This paper will summarize the current status and projects under development.

  17. Optimization of Fluid Front Dynamics in Porous Media Using Rate Control: I. Equal Mobility Fluids

    Energy Technology Data Exchange (ETDEWEB)

    Sundaryanto, Bagus; Yortsos, Yanis C.

    1999-10-18

    In applications involving this injection of a fluid in a porous medium to displace another fluid, a main objective is the maximization of the displacement efficiency. For a fixed arrangement of injection and production points (sources and sinks), such optimization is possible by controlling the injection rate policy. Despite its practical relevance, however, this aspect has received scant attention in the literature. In this paper, a fundamental approach based on optimal control theory, for the case when the fluids are miscible, of equal viscosity and in the absence of dispersion and gravity effects. Both homogeneous and heterogeneous porous media are considered. From a fluid dynamics viewpoint, this is a problem in the deformation of material lines in porous media, as a function of time-varying injection rates.

  18. Hybrid Fluid-borne Noise Control in Fluid-filled Pipelines

    Science.gov (United States)

    Pan, M.; Johnston, N.; Plummer, A.

    2016-09-01

    This article reports on an initial investigation of a hybrid fluid-borne noise control system in hydraulic pipelines. The hybrid system is built by integrating an active feedforward noise controller with passive tuned flexible hoses. The active attenuator is designed to cancel the dominant harmonic pressure pulsations in the fluid line, while the passive hose is tuned to attenuate the residual high frequency pulsations. The active attenuator can effectively decrease the fluid-borne noise by superimposing a secondary anti-phase control signal. Adaptive notch filters with the filtered-X least mean square algorithm were applied for the controller and a frequency-domain least mean square filter was used for the secondary path on-line identification. The transmission line model was used to model the pipeline, and a time-domain hose model which includes coupling of longitudinal wall and fluid waves was used to model the flexible hose. Simulation results show that very good noise cancellation was achieved using the proposed approach, which has several advantages over existing fluid-borne noise control systems, being effective for a wide range of frequencies without impairing the system dynamic response much. While the flexible hoses may be less effective than purpose-built passive silencers, they can form an inexpensive and practical solution in combination with active control.

  19. Fluid status and outcome in patients with heart failure and preserved ejection fraction.

    Science.gov (United States)

    Koell, Benedikt; Zotter-Tufaro, Caroline; Duca, Franz; Kammerlander, Andreas A; Aschauer, Stefan; Dalos, Daniel; Antlanger, Marlies; Hecking, Manfred; Säemann, Marcus; Mascherbauer, Julia; Bonderman, Diana

    2017-03-01

    Most heart failure with preserved ejection fraction (HFpEF) patients, at some point, present to an emergency department with typical symptoms of volume overload. Clinically, most respond well to standard diuretic therapy, sometimes at the cost of renal function. The study sought to define the prognostic significance of fluid status versus renal function in patients with HFpEF. One hundred sixty-two consecutive patients with HFpEF were enrolled in our prospective registry. Twelve patients with clinically overt decompensation were excluded. Fluid status at baseline was determined by bioelectrical impedance spectroscopy. The primary outcome measure was a combined end point consisting of hospitalization for heart failure and/or death for cardiac reason. Mean age was 74.4±8.4years. Ninety-one (61%) patients were hypo- or normovolemic (relative fluid overload [Rel. FO] -0.7±5.7%) while 59 (39%) patients presented with fluid overload (Rel. FO 11.5±2.7%). During a median follow-up of 24.3months (interquartile range: 19.8-33.2), 34% of patients reached the combined end point. Multivariate Cox hazard analysis identified fluid overload (hazard ratio: 3.09; 95% confidence interval: 1.68-5.68; pfluid overload and normal renal function showed a worse event-free survival compared to the subgroup with normohydration and impaired renal function (log-rank: p=0.042). HFpEF patients with measurable fluid overload face a dismal prognosis as compared to euvolemic patients. Our data, while preliminary, suggest that patients with fluid overload may face a better outcome under continued fluid removal irrespective of changes in eGFR. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  20. Review and evaluation of literature on testing of chemical additives for scale control in geothermal fluids. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Crane, C.H.; Kenkeremath, D.C.

    1981-01-01

    A selected group of reported tests of chemical additives in actual geothermal fluids are reviewed and evaluated to summarize the status of chemical scale-control testing and identify information and testing needs. The task distinguishes between scale control in the cooling system of a flash plant and elsewhere in the utilization system due to the essentially different operating environments involved. Additives for non-cooling geothermal fluids are discussed by scale type: silica, carbonate, and sulfide.

  1. Moving shape analysis and control applications to fluid structure interactions

    CERN Document Server

    Moubachir, Marwan

    2006-01-01

    Problems involving the evolution of two- and three-dimensional domains arise in many areas of science and engineering. Emphasizing an Eulerian approach, Moving Shape Analysis and Control: Applications to Fluid Structure Interactions presents valuable tools for the mathematical analysis of evolving domains. The book illustrates the efficiency of the tools presented through different examples connected to the analysis of noncylindrical partial differential equations (PDEs), such as Navier-Stokes equations for incompressible fluids in moving domains. The authors first provide all of the details of existence and uniqueness of the flow in both strong and weak cases. After establishing several important principles and methods, they devote several chapters to demonstrating Eulerian evolution and derivation tools for the control of systems involving fluids and solids. The book concludes with the boundary control of fluid-structure interaction systems, followed by helpful appendices that review some of the advanced m...

  2. On the future of controllable fluid film bearings

    DEFF Research Database (Denmark)

    Santos, Ilmar

    2011-01-01

    This work gives an overview of the theoretical and experimental achievements of mechatronics applied to fluid film bearings. Compressible and uncompressible fluids are addressed. Rigid and elastic (deformable) bearing profiles are investigated. Hydraulic, pneumatic, magnetic and piezoelectric...... controllable fluid film bearings is to improve the overall machine performance by: controlling the lateral vibration of rigid and flexible rotating shafts; modifying bearing dynamic characteristics, such as stiffness and damping properties; increasing the rotational speed ranges by enhancing damping...... and eliminating instability problems, for example, by compensating cross-coupling destabilizing effects; reducing start-up torque and energy dissipation in bearings; compensating thermal effects. It is shown that such controllable fluid film bearings can act as “smart” machine components and be applied...

  3. Agarwood Waste as A New Fluid Loss Control Agent in Water-based Drilling Fluid

    Directory of Open Access Journals (Sweden)

    Azlinda Azizi

    2013-10-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 Agarwood has been used widely in various ways, including traditional medicine and art. The usage of agarwood has grown broader in modern times include in therapeutic medicines and perfumery. In this paper the agarwood waste has been explored to be used as a fluid loss control agent to control fluid loss without affecting the drilling fluid rheological properties which are density, pH, viscosity, yield point and gel strength. Agarwood waste was used as an additive in the drilling fluid system due to its unique characteristic. Rheological and filtration measurements were performed on the formulated water-based drilling fluid. Formulations of a base solution of fresh water, sodium hydroxide, bentonite, barite, and xanthan gum were presented. The performance of the agarwood waste as the fluid loss control agent was compared with based fluid formulation and water-based drilling fluid with treating with conventional fluid loss control agent (starch. The filtrate volume of drilling fluid with agarwood waste was about 13 ml while for drilling fluid with conventional fluid loss control agent, starch gave 12 ml of filtrate volume after undergoing filtration test by using LPLT filter press. The performance of drilling fluid with agarwood was efficient as drilling fluid with starch. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso

  4. Controlled capillary assembly of magnetic Janus particles at fluid-fluid interfaces.

    Science.gov (United States)

    Xie, Qingguang; Davies, Gary B; Harting, Jens

    2016-08-21

    Capillary interactions can be used to direct assembly of particles adsorbed at fluid-fluid interfaces. Precisely controlling the magnitude and direction of capillary interactions to assemble particles into favoured structures for materials science purposes is desirable but challenging. In this paper, we investigate capillary interactions between magnetic Janus particles adsorbed at fluid-fluid interfaces. We develop a pair-interaction model that predicts that these particles should arrange into a side-side configuration, and carry out simulations that confirm the predictions of our model. Finally, we investigate the monolayer structures that form when many magnetic Janus particles adsorb at the interface. We find that the particles arrange into long, straight chains exhibiting little curvature, in contrast with capillary interactions between ellipsoidal particles. We further find a regime in which highly ordered, lattice-like monolayer structures form, which can be tuned dynamically using an external magnetic field.

  5. Hydration Status and Fluid Balance of Elite European Youth Soccer Players during Consecutive Training Sessions

    Directory of Open Access Journals (Sweden)

    Shaun M. Phillips

    2014-12-01

    Full Text Available The objective of the study was to investigate the hydration status and fluid balance of elite European youth soccer players during three consecutive training sessions. Fourteen males (age 16.9 ± 0.8 years, height 1.79 ± 0.06 m, body mass (BM 70.6 ± 5.0 kg had their hydration status assessed from first morning urine samples (baseline and pre- and post-training using urine specific gravity (USG measures, and their fluid balance calculated from pre- to post-training BM change, corrected for fluid intake and urine output. Most participants were hypohydrated upon waking (USG >1.020; 77% on days 1 and 3, and 62% on day 2. There was no significant difference between first morning and pre-training USG (p = 0.11 and no influence of training session (p = 0.34 or time (pre- vs. post-training; p = 0.16 on USG. Significant BM loss occurred in sessions 1-3 (0.69 ± 0.22, 0.42 ± 0.25, and 0.38 ± 0.30 kg respectively, p < 0.05. Mean fluid intake in sessions 1-3 was 425 ± 185, 355 ± 161, and 247 ± 157 ml, respectively (p < 0.05. Participants replaced on average 71.3 ± 64.1% (range 0-363.6% of fluid losses across the three sessions. Body mass loss, fluid intake, and USG measures showed large inter-individual variation. Elite young European soccer players likely wake and present for training hypohydrated, when a USG threshold of 1.020 is applied. When training in a cool environment with ad libitum access to fluid, replacing ~71% of sweat losses results in minimal hypohydration (<1% BM. Consumption of fluid ad libitum throughout training appears to prevent excessive (≥2% BM dehydration, as advised by current fluid intake guidelines. Current fluid intake guidelines appear applicable for elite European youth soccer players training in a cool environment.

  6. On Controllable Elastohydrodynamic Fluid Film Bearings

    DEFF Research Database (Denmark)

    Haugaard, Martin Asger

    This thesis gives a theoretical description of the active tilting-pad journal bearing (ATPJB). It provides the qualified reader with the tools to model an ATPJB, while staying clear of pitfalls. The model is based on well known techniques and allows for local stability analyses, harmonic stationary...... are performed for a tilting-pad journal bearing (TPJB) and an ATPJB under static conditions, followed by a generalisation to dynamic conditions (transient as well as stationary harmonic). These analyses will be of interest to experimentalists, since they permit experiments performed on scaled down test rigs...... the addition of a control system may just as well harm rotor-bearing performance as improve it....

  7. Vibration control by smart structure with electrorheological fluid

    Science.gov (United States)

    Machida, Shigeru; Matsuzaki, Yuji; Hagi, Toshiyuki

    2001-08-01

    The active vibration with smart material has potential to realize not only distributed actuator and sensor but also simplified and light weight active control methods. Electro-Rheological Fluid can produce shear force according to voltage of electrical field and respond quickly enough to control structure. In this paper, control methods to achieve effective damping are described. The key points are modeling the smart structure with Electro-Rheological Fluid and control methods for reducing vibration. The nonlinear model is derived to identify physical parameters of Electro- Rheological Fluid. The vibration test results of small specimens show that this analytical model can express electro-rheological effect. The analytical model is made for larger specimen in the same manner. The effects of vibration reduction with Electro-Rheological Fluid on the bema structure are investigated as the vibration control system, where the strength of electrical field for input and minimizing the transmissibility of vibratory loads for objective analytically. As the results of this study, it is revealed that smart structure embedded ERF can achieve the expected damping performance. Some technical issues of control method for applying to any actual structures are discussed.

  8. Magnetic fluids - suspensions of magnetic dipoles and their magnetic control

    CERN Document Server

    Odenbach, S

    2003-01-01

    Suspensions of magnetic nanoparticles exhibit normal liquid behaviour coupled with superparamagnetic properties. This leads to the possibility to control the properties and the flow of these liquids with moderate magnetic fields. The magnetic control enables various experiments in fluid mechanics and gives rise to the development of numerous technical and medical applications. Ferrofluids and their general properties will be introduced and, as examples for the magnetic control of their flow and properties, thermomagnetic convection and magnetoviscous effects will be discussed in some detail.

  9. 46 CFR 58.30-50 - Requirements for miscellaneous fluid power and control systems.

    Science.gov (United States)

    2010-10-01

    ...) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS Fluid Power and Control Systems § 58.30-50 Requirements for miscellaneous fluid power and control systems. (a) All fluid power and control... 46 Shipping 2 2010-10-01 2010-10-01 false Requirements for miscellaneous fluid power and control...

  10. Neuroendocrine control of body fluid homeostasis

    Directory of Open Access Journals (Sweden)

    McCann S.M.

    2003-01-01

    Full Text Available Angiotensin II and atrial natriuretic peptide (ANP play important and opposite roles in the control of water and salt intake, with angiotensin II promoting the intake of both and ANP inhibiting the intake of both. Following blood volume expansion, baroreceptor input to the brainstem induces the release of ANP within the hypothalamus that releases oxytocin (OT that acts on its receptors in the heart to cause the release of ANP. ANP activates guanylyl cyclase that converts guanosine triphosphate into cyclic guanosine monophosphate (cGMP. cGMP activates protein kinase G that reduces heart rate and force of contraction, decreasing cardiac output. ANP acts similarly to induce vasodilation. The intrinsic OT system in the heart and vascular system augments the effects of circulating OT to cause a rapid reduction in effective circulating blood volume. Furthermore, natriuresis is rapidly induced by the action of ANP on its tubular guanylyl cyclase receptors, resulting in the production of cGMP that closes Na+ channels. The OT released by volume expansion also acts on its tubular receptors to activate nitric oxide synthase. The nitric oxide released activates guanylyl cyclase leading to the production of cGMP that also closes Na+ channels, thereby augmenting the natriuretic effect of ANP. The natriuresis induced by cGMP finally causes blood volume to return to normal. At the same time, the ANP released acts centrally to decrease water and salt intake.

  11. Magnetic fluid readily controlled in zero gravity environment

    Science.gov (United States)

    Papell, S. S.

    1965-01-01

    Colloid composed of finely ground iron oxide in a fluid such as heptane, is controlled and directed magnetically in a zero gravity environment. It will not separate on standing for long periods or after exposure to magnetic or centrifugal forces. Because of its low density and low viscosity, it is easily pumped.

  12. Storage Capacity Explains Fluid Intelligence but Executive Control Does Not

    Science.gov (United States)

    Chuderski, Adam; Taraday, Maciej; Necka, Edward; Smolen, Tomasz

    2012-01-01

    We examined whether fluid intelligence (Gf) is better predicted by the storage capacity of active memory or by the effectiveness of executive control. In two psychometric studies, we measured storage capacity with three kinds of task which required the maintenance of a visual array, the monitoring of simple relations among perceptually available…

  13. Fluid Mechanics of Wing Adaptation for Separation Control

    Science.gov (United States)

    Chandrasekhara, M. S.; Wilder, M. C.; Carr, L. W.; Davis, Sanford S. (Technical Monitor)

    1997-01-01

    The unsteady fluid mechanics associated with use of a dynamically deforming leading edge airfoil for achieving compressible flow separation control has been experimentally studied. Changing the leading edge curvature at rapid rates dramatically alters the flow vorticity dynamics which is responsible for the many effects observed in the flow.

  14. Status of the CMS Detector Control System

    CERN Document Server

    Bauer, Gerry; Bouffet, Olivier; Bowen, Matthew; Branson, James G; Bukowiec, Sebastian; Ciganek, Marek; Cittolin, Sergio; Jose Antonio Coarasa; Deldicque, Christian; Dobson, Marc; Dupont, Aymeric; Erhan, Samim; Flossdorf, Alexander; Gigi, Dominique; Glege, Frank; Gomez-Reino, Robert; Hartl, Christian; Hegeman, Jeroen; Holzner, André; Yi Ling Hwong; Masetti, Lorenzo; Meijers, Frans; Meschi, Emilio; Mommsen, Remigius K; O'Dell, Vivian; Orsini, Luciano; Paus, Christoph; Petrucci, Andrea; Pieri, Marco; Polese, Giovanni; Racz, Attila; Raginel, Olivier; Sakulin, Hannes; Sani, Matteo; Schwick, Christoph; Shpakov, Dennis; Simon, Michal; Andrei Cristian Spataru; Sumorok, Konstanty

    2012-01-01

    The Compact Muon Solenoid (CMS) is a CERN multi-purpose experiment that exploits the physics of the Large Hadron Collider (LHC). The Detector Control System (DCS) ensures a safe, correct and efficient experiment operation, contributing to the recording of high quality physics data. The DCS is programmed to automatically react to the LHC operational mode. CMS sub-detectors' bias voltages are set depending on the machine mode and particle beam conditions. An operator provided with a small set of screens supervises the system status summarized from the approximately 6M monitored parameters. Using the experience of nearly two years of operation with beam the DCS automation software has been enhanced to increase the system efficiency by minimizing the time required by sub detectors to prepare for physics data taking. From the infrastructure point of view the DCS will be subject to extensive modifications in 2012. The current rack mounted control PCs will be exchanged by a redundant pair of DELL Blade systems. Thes...

  15. Assessment of smoking status based on cotinine levels in nasal lavage fluid

    Directory of Open Access Journals (Sweden)

    Cowart Beverly J

    2009-07-01

    Full Text Available Abstract Cotinine is a principal metabolite of nicotine with a substantially longer half-life, and cotinine levels in saliva, urine or serum are widely used to validate self-reported smoking status. The nasal cavity and olfactory system are directly exposed to tobacco smoke in smokers and in non-smokers who live with or work around smokers. However, despite the potential for a direct impact of tobacco smoke on the nasal epithelium and olfactory neurons, no prior studies have assessed cotinine levels in nasal mucus. We sought to determine whether cotinine levels in nasal lavage fluid (NLF would provide a reasonable estimate of smoke exposure. We assayed cotinine using a competitive immunoassay in NLF from 23 smokers, 10 non-smokers exposed to tobacco smoke (ETS and 60 non-smokers who did not report smoke exposure. NLF cotinine levels were significantly higher in smokers than in non-smokers, regardless of their exposure to ambient tobacco smoke. Cotinine levels in this small group of exposed non-smokers were not significantly different than those of non-exposed non-smokers. A cutoff of 1 ng/ml provided a sensitivity of 91% and a specificity of 99% for smoking status in this sample. Data were consistent with self-reported smoking status, and a cutoff of 1.0 ng/ml NLF cotinine may be used to classify smoking status. While saliva is the most easily obtained body fluid, NLF can be used to provide an objective and precise indication of smoking status and more directly reflects smoke exposure in the nasal and olfactory mucosa.

  16. Optimization of fluid front dynamics in porous media using rate control. I. Equal mobility fluids

    Energy Technology Data Exchange (ETDEWEB)

    Sudaryanto, Bagus [Petroleum Engineering Program, Department of Chemical Engineering, University of Southern California, Los Angeles, California 90089-1211 (United States); Yortsos, Yannis C. [Petroleum Engineering Program, Department of Chemical Engineering, University of Southern California, Los Angeles, California 90089-1211 (United States)

    2000-07-01

    In applications involving the injection of a fluid in a porous medium to displace another fluid, a main objective is the maximization of the displacement efficiency. For a fixed arrangement of injection and production points (sources and sinks), such optimization is possible by controling the injection rate policy. Despite its practical relevance, however, this aspect has received scant attention in the literature. In this paper, we provide a fundamental approach based on optimal control theory, for the simplified case when the fluids are miscible, of equal viscosity, and in the absence of dispersion and gravity effects. Both homogeneous and heterogeneous porous media are considered. From a fluid dynamics viewpoint, this is a problem in the deformation of material lines in porous media, as a function of time-varying injection rates. It is shown that the optimal injection policy that maximizes the displacement efficiency, at the time of arrival of the injected fluid, is of the ''bang-bang'' type, in which the rates take their extreme values in the range allowed. This result applies to both homogeneous and heterogeneous media. Examples in simple geometries and for various constraints are shown, illustrating the efficiency improvement over the conventional approach of constant rate injection. In the heterogeneous case, the effect of the permeability heterogeneity, particularly its spatial correlation structure, on diverting the flow paths, is analyzed. It is shown that bang-bang injection remains the optimal approach, compared to constant rate, particularly if they were both designed under the assumption that the medium was homogeneous. Experiments in a homogeneous Hele-Shaw cell are found to be in good agreement with the theory. (c) 2000 American Institute of Physics.

  17. Numerical modelling of structural controls on fluid flow and mineralization

    Directory of Open Access Journals (Sweden)

    Yanhua Zhang

    2011-07-01

    Full Text Available This paper presents the results of a set of numerical models focussing on structural controls on hydrothermal mineralization. We first give an overview of natural phenomena of structurally-controlled ore formation and the background theory and mechanisms for such controls. We then provide the results of a group of simple 2D numerical models validated through comparison with Cu-vein structure observed near the Shilu Copper deposit (Yangchun, Guangdong Province, China and finally a case study of 3D numerical modelling applied to the Hodgkinson Province in North Queensland (Australia. Two modelling approaches, discrete deformation modelling and continuum coupled deformation and fluid flow modelling, are involved. The 2D model-derived patterns are remarkably consistent with the Cu-vein structure from the Shilu Copper deposit, and show that both modelling approaches can realistically simulate the mechanical behaviours of shear and dilatant fractures. The continuum coupled deformation and fluid flow model indicates that pattern of the Cu-veins near the Shilu deposit is the result of shear strain localization, development of dilation and fluid focussing into the dilatant fracture segments. The 3D case-study models (with deformation and fluid flow coupling on the Hodgkinson Province generated a number of potential gold mineralization targets.

  18. Impact of fluid status and inflammation and their interaction on survival: a study in an international hemodialysis patient cohort.

    Science.gov (United States)

    Dekker, Marijke J E; Marcelli, Daniele; Canaud, Bernard J; Carioni, Paola; Wang, Yuedong; Grassmann, Aileen; Konings, Constantijn J A M; Kotanko, Peter; Leunissen, Karel M; Levin, Nathan W; van der Sande, Frank M; Ye, Xiaoling; Maheshwari, Vaibhav; Usvyat, Len A; Kooman, Jeroen P

    2017-05-01

    In hemodialysis patients extracellular fluid overload is a predictor of all-cause and cardiovascular mortality, and a relation with inflammation has been reported in previous studies. The magnitude and nature of this interaction and the effects of moderate fluid overload and extracellular fluid depletion on survival are still unclear. We present the results of an international cohort study in 8883 hemodialysis patients from the European MONDO initiative database where, during a three-month baseline period, fluid status was assessed using bioimpedance and inflammation by C-reactive protein. All-cause mortality was recorded during 12 months of follow up. In a second analysis a three-month baseline period was added to the first baseline period, and changes in fluid and inflammation status were related to all-cause mortality during six-month follow up. Both pre-dialysis estimated fluid overload and fluid depletion were associated with an increased mortality, already apparent at moderate levels of estimated pre-dialysis fluid overload (1.1-2.5L); hazard ratio 1.64 (95% confidence interval 1.35-1.98). In contrast, post-dialysis estimated fluid depletion was associated with a survival benefit (0.74 [0.62-0.90]). The concurrent presence of fluid overload and inflammation was associated with the highest risk of death. Thus, while pre-dialysis fluid overload was associated with inflammation, even in the absence of inflammation, fluid overload remained a significant risk factor for short-term mortality, even following improvement of fluid status. Copyright © 2016 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

  19. A magnetorheological fluid-based controllable active knee brace

    Science.gov (United States)

    Ahmadkhanlou, Farzad; Zite, Jamaal L.; Washington, Gregory N.

    2007-04-01

    High customization costs and reduction of natural mobility put current rehabilitative knee braces at a disadvantage. A resolution to this problem is to integrate a Magnetorheological (MR) fluid-based joint into the system. A MR joint will allow patients to apply and control a resistive torque to knee flexion and extension. The resistance torque can also be continuously adjusted as a function of extension angle and patient strength (or as a function of time), which is currently impossible with state of the art rehabilitative knee braces. A novel MR fluid-based controllable knee brace is designed and prototyped in this research. The device exhibits large resistive torque in the on-state and low resistance in the offstate. The controllable variable stiffness, compactness, and portability of the system make it a proper alternative to current rehabilitative knee braces.

  20. The CFVib Experiment: Control of Fluids in Microgravity with Vibrations

    Science.gov (United States)

    Fernandez, J.; Sánchez, P. Salgado; Tinao, I.; Porter, J.; Ezquerro, J. M.

    2017-08-01

    The Control of Fluids in Microgravity with Vibrations (CFVib) experiment was selected for the 2016 Fly Your Thesis! programme as part of the 65th ESA Parabolic Flight Campaign. The aim of the project is to observe the potentially complex behaviour of vibrated liquids in weightless environments and to investigate the extent to which small-amplitude vibrations can be used to influence and control this behaviour. Piezoelectric materials are used to generate high-frequency vibrations to drive surface waves and large-scale reorientation of the interface. The theory of vibroequilibria, which treats the quasi-stationary surface configurations achieved by this reorientation, was used to predict interesting parameter regimes and interpret fluid behaviour. Here we describe the scientific motivation, objectives, and design of the experiment.

  1. Immunosensor with Fluid Control Mechanism for Salivary Cortisol Analysis

    OpenAIRE

    Yamaguchi, Masaki; Matsuda, Yohei; Sasaki, Shohei; Sasaki, Makoto; Kadoma, Yoshihiro; Imai, Yoshikatsu; Niwa, Daisuke; Shetty, Vivek

    2012-01-01

    The purpose of this research is to demonstrate a new design for a cortisol immunosensor for the noninvasive and quantitative analysis of salivary cortisol. We propose a cortisol immunosensor with a fluid control mechanism which has both a vertical flow and a lateral flow. The detected current resulting from a competitive reaction between the sample cortisol and a glucose oxidase (GOD)-labeled cortisol conjugate was found to be inversely related to the concentration of cortisol in the sample s...

  2. Physical therapy applications of MR fluids and intelligent control

    Science.gov (United States)

    Dong, Shufang; Lu, Ke-Qian; Sun, J. Q.; Rudolph, Katherine

    2005-05-01

    Resistance exercise has been widely reported to have positive rehabilitation effects for patients with neuromuscular and orthopaedic conditions. This paper presents an optimal design of magneto-rheological fluid dampers for variable resistance exercise devices. Adaptive controls for regulating the resistive force or torque of the device as well as the joint motion are presented. The device provides both isometric and isokinetic strength training for various human joints.

  3. Steady State Stokes Flow Interpolation for Fluid Control

    DEFF Research Database (Denmark)

    Bhatacharya, Haimasree; Nielsen, Michael Bang; Bridson, Robert

    2012-01-01

    Fluid control methods often require surface velocities interpolated throughout the interior of a shape to use the velocity as a feedback force or as a boundary condition. Prior methods for interpolation in computer graphics — velocity extrapolation in the normal direction and potential flow...... — suffer from a common problem. They fail to capture the rotational components of the velocity field, although extrapolation in the normal direction does consider the tangential component. We address this problem by casting the interpolation as a steady state Stokes flow. This type of flow captures...... the rotational components and is suitable for controlling liquid animations where tangential motion is pronounced, such as in a breaking wave...

  4. Silica recovery and control in Hawaiian geothermal fluids

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, D.M.

    1992-06-01

    A series of experiments was performed to investigate methods of controlling silica in waste geothermal brines produced at the HGP-A Generator Facility. Laboratory testing has shown that the rate of polymerization of silica in the geothermal fluids is highly pH dependent. At brine pH values in excess of 8.5 the suspension of silica polymers flocculated and rapidly precipitated a gelatinous silica mass. Optimum flocculation and precipitation rates were achieved at pH values in the range of 10.5 to 11.5. The addition of transition metal salts to the geothermal fluids similarly increased the rate of polymerization as well as the degree of precipitation of the silica polymer from suspension. A series of experiments performed on the recovered silica solids demonstrated that methanol extraction of the water in the gels followed by critical point drying yielded surface areas in excess of 300 M{sup 2}/g and that treatment of the dried solids with 2 N HCl removed most of the adsorbed impurities in the recovered product. A series of experiments tested the response of the waste brines to mixing with steam condensate and non-condensable gases.The results demonstrated that the addition of condensate and NCG greatly increased the stability of the silica in the geothermal brines. They also indicated that the process could reduce the potential for plugging of reinjection wells receiving waste geothermal fluids from commercial geothermal facilities in Hawaii. Conceptual designs were proposed to apply the gas re-combination approach to the disposal of geothermal waste fluids having a range of chemical compositions. Finally, these designs were applied to the geothermal fluid compositions found at Cerro Prieto, Ahuachapan, and Salton Sea.

  5. Silica recovery and control in Hawaiian geothermal fluids. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, D.M.

    1992-06-01

    A series of experiments was performed to investigate methods of controlling silica in waste geothermal brines produced at the HGP-A Generator Facility. Laboratory testing has shown that the rate of polymerization of silica in the geothermal fluids is highly pH dependent. At brine pH values in excess of 8.5 the suspension of silica polymers flocculated and rapidly precipitated a gelatinous silica mass. Optimum flocculation and precipitation rates were achieved at pH values in the range of 10.5 to 11.5. The addition of transition metal salts to the geothermal fluids similarly increased the rate of polymerization as well as the degree of precipitation of the silica polymer from suspension. A series of experiments performed on the recovered silica solids demonstrated that methanol extraction of the water in the gels followed by critical point drying yielded surface areas in excess of 300 M{sup 2}/g and that treatment of the dried solids with 2 N HCl removed most of the adsorbed impurities in the recovered product. A series of experiments tested the response of the waste brines to mixing with steam condensate and non-condensable gases.The results demonstrated that the addition of condensate and NCG greatly increased the stability of the silica in the geothermal brines. They also indicated that the process could reduce the potential for plugging of reinjection wells receiving waste geothermal fluids from commercial geothermal facilities in Hawaii. Conceptual designs were proposed to apply the gas re-combination approach to the disposal of geothermal waste fluids having a range of chemical compositions. Finally, these designs were applied to the geothermal fluid compositions found at Cerro Prieto, Ahuachapan, and Salton Sea.

  6. Measurements of fluid transport by controllable vertical migrations of plankton

    Science.gov (United States)

    Houghton, Isabel A.; Dabiri, John O.

    2016-11-01

    Diel vertical migration of zooplankton has been proposed to be a significant contributor to local and possibly large-scale fluid transport in the ocean. However, studies of this problem to date have been limited to order-of-magnitude estimates based on first principles and a small number of field observations. In this work, we leverage the phototactic behavior of zooplankton to stimulate controllable vertical migrations in the laboratory and to study the associated fluid transport and mixing. Building upon a previous prototype system, a laser guidance system induces vertical swimming of brine shrimp (Artemia salina) in a 2.1 meter tall, density-stratified water tank. The animal swimming speed and spacing during the controlled vertical migration is characterized with video analysis. A schlieren imaging system is utilized to visualize density perturbations to a stable stratification for quantification of fluid displacement length scales and restratification timescales. These experiments can add to our understanding of the dynamics of active particles in stratified flows. NSF and US-Israel Binational Science Foundation.

  7. Association of Fluid Status and Body Composition with Physical Function in Patients with Chronic Kidney Disease

    Science.gov (United States)

    Hsiao, Shih-Ming; Tsai, Yi-Chun; Chen, Hui-Mei; Lin, Ming-Yen; Chiu, Yi-Wen; Chen, Tzu-Hui; Wang, Shu-Li; Hsiao, Pei-Ni; Kung, Lan-Fang; Hwang, Shang-Jyh; Huang, Mei-Feng; Yeh, Yi-Chun; Chen, Cheng-Sheng; Kuo, Mei-Chuan

    2016-01-01

    Background Impairment of physical function and abnormal body composition are the major presentations in patients with chronic kidney disease (CKD). The aim of this study is to investigate the relationship between body composition and physical function in CKD patients. Methods This cross-sectional study enrolled 172 of CKD stages 1–5 from February 2013 to September 2013. Handgrip strength (upper extremity muscle endurance), 30-second chair-stand test (lower extremity muscle endurance) and 2-minute step test (cardiorespiratory endurance) were used as indices of physical function. Body composition, including fluid status (extracellular water/total body water, ECW/TBW), lean tissue index (LTI), and fat tissue index (FTI), was measured using a bioimpedance spectroscopy method. Results All patients with high ECW/TBW had lower handgrip strength and 30-second chair-stand than those with low ECW/TBW (P<0.001 and P = 0.002). CKD patients with high FTI had lower handgrip strength and 30-second chair-stand than those with low FTI (P<0.001 and P = 0.002). These patients with low LTI had lower handgrip strength than those with high LTI (P = 0.04). In multivariate analysis, high ECW/TBW was positively associated with decreased handgrip strength (β = -41.17, P = 0.03) in CKD patients. High FTI was significantly correlated with decreased times of 30-second chair-stand (β = -0.13, P = 0.01). There was no significant relationship between body composition and 2-minute step test. Conclusions Our results show a significant association of impaired upper and lower extremity muscle endurance with high fluid status and fat tissue. Evaluation of body composition may assist in indentifying physical dysfunction earlier in CKD patients. PMID:27798648

  8. Controlling Subsurface Fractures and Fluid Flow: A Basic Research Agenda

    Energy Technology Data Exchange (ETDEWEB)

    Pyrak-Nolte, Laura J [Purdue Univ., West Lafayette, IN (United States); DePaolo, Donald J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States); Pietraß, Tanja [USDOE Office of Science, Washington, DC (United States)

    2015-05-22

    From beneath the surface of the earth, we currently obtain about 80-percent of the energy our nation consumes each year. In the future we have the potential to generate billions of watts of electrical power from clean, green, geothermal energy sources. Our planet’s subsurface can also serve as a reservoir for storing energy produced from intermittent sources such as wind and solar, and it could provide safe, long-term storage of excess carbon dioxide, energy waste products and other hazardous materials. However, it is impossible to underestimate the complexities of the subsurface world. These complexities challenge our ability to acquire the scientific knowledge needed for the efficient and safe exploitation of its resources. To more effectively harness subsurface resources while mitigating the impacts of developing and using these resources, the U.S. Department of Energy established SubTER – the Subsurface Technology and Engineering RD&D Crosscut team. This DOE multi-office team engaged scientists and engineers from the national laboratories to assess and make recommendations for improving energy-related subsurface engineering. The SubTER team produced a plan with the overall objective of “adaptive control of subsurface fractures and fluid flow.”This plan revolved around four core technological pillars—Intelligent Wellbore Systems that sustain the integrity of the wellbore environment; Subsurface Stress and Induced Seismicity programs that guide and optimize sustainable energy strategies while reducing the risks associated with subsurface injections; Permeability Manipulation studies that improve methods of enhancing, impeding and eliminating fluid flow; and New Subsurface Signals that transform our ability to see into and characterize subsurface systems. The SubTER team developed an extensive R&D plan for advancing technologies within these four core pillars and also identified several areas where new technologies would require additional basic research

  9. Therapeutic Options for Controlling Fluids in the Visual System

    Science.gov (United States)

    Curry, Kristina M.; Wotring, Virginia E.

    2014-01-01

    Visual Impairment/Intracranial Pressure (VIIP) is a newly recognized risk at NASA. The VIIP project examines the effect of long-term exposure to microgravity on vision of crewmembers before and after they return to Earth. Diamox (acetazolamide) is a medication which is used to decrease intraocular pressure; however, it carries a 3% risk of kidney stones. Astronauts are at a higher risk of kidney stones during spaceflight and the use Diamox would only increase the risk; therefore alternative therapies were investigated. Histamine 2 (H2) antagonist acid blockers such as cimetidine, ranitidine, famotidine and nizatidine are typically used to relieve the symptoms of gastroesophageal reflux disease (GERD). H2 receptors have been found in the human visual system, which has led to research on the use of H2 antagonist blockers to control fluid production in the human eye. Another potential therapeutic strategy is targeted at aquaporins, which are water channels that help maintain fluid homeostasis. Aquaporin antagonists are also known to affect intracranial pressure which can in turn alter intraocular pressure. Studies on aquaporin antagonists suggest high potential for effective treatment. The primary objective of this investigation is to review existing research on alternate medications or therapy to significantly reduce intracranial and intraocular pressure. A literature review was conducted. Even though we do not have all the answers quite yet, a considerable amount of information was discovered, and findings were narrowed, which should allow for more conclusive answers to be found in the near future.

  10. Power, Control and Status in Physical Education.

    Science.gov (United States)

    Thomson, Ian

    2003-01-01

    For most of the 20th century, Scottish teacher education in physical education, sport, and recreation were divided by gender and philosophy and provided by two specialist colleges. Analysis of the government's 1986 decision to merge the colleges focuses on the shift in power and control from the self-contained world of physical education to…

  11. Controlled Nuclear Fusion: Status and Outlook

    Science.gov (United States)

    Rose, David J.

    1971-01-01

    Presents the history, current concerns and potential developments of nuclear fusion as a major energy source. Controlled fusion research is summarized, technological feasibility is discussed and environmental factors are examined. Relationships of alternative energy sources as well as energy utilization are considered. (JM)

  12. Field-controlled adhesion in confined magnetorheological fluids

    Science.gov (United States)

    Miranda, Jose; Lira, Sergio

    2009-11-01

    The study of reversible, functional, and controllable adhesives is a matter of considerable practical interest, and academic research. We report the adhesive response of a magnetorheological fluid confined between two parallel plates under a probe-tack test, when it is subjected to an applied magnetic field. Our analytical approach is based on a Darcy-like law formulation which considers a magnetic field-dependent yield stress behavior. The adhesion force is calculated in closed-form for two different configurations produced by a Helmholtz coils setup: uniform perpendicular, and nonuniform radial magnetic fields. In both cases, we verify that adhesion force is hugely increased as a result of the field-dependent nature of the yield stress. This provides a versatile way to obtain a shear resistant, tough structural adhesive through magnetic means.

  13. Hermes flight control center: Definition status

    Science.gov (United States)

    Letalle, Pierre

    1990-10-01

    The Hermes Flight Control Center (HFCC) located in Toulouse (France) is described. The center is the third in the world after the American center in Houston and the Soviet center in Kaliningrad. All the Hermes elements, both on board and on the ground will be coordinated by the HFCC for all phases of each mission. Aspects of the detailed definition phase still in the requirements analysis subphase are described. Diagrams are used to illustrate the interplay between the different systems.

  14. Review of magnetorheological (MR) fluids and its applications in vibration control

    Institute of Scientific and Technical Information of China (English)

    MUHAMMAD Aslam; YAO Xiong-liang; DENG Zhong-chao

    2006-01-01

    Magnetorheological (MR) fluids are now well established as one of the leading materials for use in controllable structures and systems. Commercial application of MR fluids in various fields,particularly in the vibration control, has grown rapidly over the past few years. In this paper, properties of magnetorheological (MR) fluids ,its applications in suspensions of vehicles, suspension of trains, high buildings cable-stayed bridges have been discussed. The scope of MR fluids in future, problems and some suggestions are also presented. Finally, effectiveness of MR fluids in vibration control of marine diesel engine through experiment is briefly discussed by the author.

  15. [Present status and trend of heart fluid mechanics research based on medical image analysis].

    Science.gov (United States)

    Gan, Jianhong; Yin, Lixue; Xie, Shenghua; Li, Wenhua; Lu, Jing; Luo, Anguo

    2014-06-01

    With introduction of current main methods for heart fluid mechanics researches, we studied the characteristics and weakness for three primary analysis methods based on magnetic resonance imaging, color Doppler ultrasound and grayscale ultrasound image, respectively. It is pointed out that particle image velocity (PIV), speckle tracking and block match have the same nature, and three algorithms all adopt block correlation. The further analysis shows that, with the development of information technology and sensor, the research for cardiac function and fluid mechanics will focus on energy transfer process of heart fluid, characteristics of Chamber wall related to blood fluid and Fluid-structure interaction in the future heart fluid mechanics fields.

  16. Fluid-loss control for high-permeability rocks in hydraulic fracturing under realistic shear conditions

    Energy Technology Data Exchange (ETDEWEB)

    Navarrete, R.C.; Mitchell, J.P.

    1995-12-31

    A study is presented on the effectiveness of different combinations of fluid and fluid-loss additives to control fluid loss in high-permeability formations under high shear rates. The impact on matrix damage and proppant-pack damage is also studied. Borate-crosslinked guars, hydroxyethylcellulose (HEC) and a surfactant water-base gravel packing fluid were investigated. The fluid-loss additive considered was silica flour. All fluid-loss tests were run in dynamic fluid-loss cells. To properly test high-permeability cores, new long core dynamic fluid-loss cells were used. The matrix damage caused by the invasion of the fluid was determined using pressure taps along the core. Conductivity tests were also run to determine the damage to the proppant pack. Results show that the effectiveness of particulate fluid-loss additives under dynamic conditions is strongly dependent on the initial leakoff rate, which depends on the pressure gradient across the core, permeability of the core and viscosity of the invading fluid. The use of silica flour helps matrix flowback, and it has a minimal effect on proppant-pack conductivity in clean fluids (e.g., surfactant water-base gravel packing fluid). With the exception of the borate-crosslinked guar with no fluid-loss additive, the variety of fluids used in these tests (with and without silica flour) have a negligible effect on postproduction.

  17. Status of fertility control in Egypt.

    Science.gov (United States)

    Hefnawi, F I

    1982-01-01

    The concern for fertility control is not alien to the cultural and religious heritage of Egypt. Historically, Egyptian interest in fertility dates to the Pharoahs. Contraceptive recipes written at least 15-18 centuries B.C. have been found. Romans may have borrowed some of the more effective methods from Egypt when it became part of the Roman Empire as evidenced by the decline in size of aristocratic Roman families at the beginning of the Christian era. Muslim conquerors of Egypt encouraged fertility control. In the 9th century differences of opinion about the legality of contraception appeared among the interpreters of Islamic law. Some methods found in the writings of Muslim doctors as al-Razi and Avicenna still survive in the folk medicine of Egypt. In modern times use of barrier methods of contraception were encouraged by family planning organizations in Egypt. The medical profession was not deeply involved since these methods did not require much medical assistance. In 1936 a religiouss verdict declared contraception to be a lawful act of Islam. National programs in family planning in the 1960's encouraged the use of the Lippes Loop IUD. The medical problem of blood loss associated with the IUD caused anxiety because of the high incidence of anemia in the female Egyptian population. There was also a cultural limitation on the wide use of the IUD. "Spotting" due to the IUD resulted in females being ritually unclean and therefore unfit to pray or observe the Islamic fast. The Pill, initially favored caused complications due to its effect on breast milk which is the universal source of nutrition for infants in Egypt. Replacement of the Pill by depo-provera injections during the post partum period of lactation is a practical solution. Permanent sterilization is limited to females and only performed when medically indicated. Abortion is illegal and permitted only as a therapeutic measure.

  18. RESEARCH OF ULTRASONIC SENSING AND MIXING ELEMENTS FOR CONTROL OF MAGNETORHEOLOGICAL FLUIDS STABILITY

    Directory of Open Access Journals (Sweden)

    E. Dragašius

    2011-01-01

    Full Text Available  Using of magnetorheological fluids (MRF can reduce energy costs and weight and increase the devices speed and lifetime. In order to fully use all the qualities of MRF properties one must from time to time mix them and measure their properties. These systems are still being designed and tested in the laboratories. There are many structures with rheological fluid, but in many devices fluids are sealed and mechanical mixing and direct measurement of fluid properties are not possible. Effective stability control system for the rheological fluids, which supports homogeneity of the fluid, is described

  19. Levels of interleukin-1β in gingival crevicular fluid in patients with coronary heart disease and its relationship to periodontal status

    Science.gov (United States)

    Lenggogeny, Putri; Masulili, Sri Lelyati C.; Tadjoedin, Fatimah M.; Radi, Basuni

    2017-02-01

    Periodontitis is a risk factor for coronary heart disease (CHD). Both diseases are an inflammatory diseases and have the same potential pathogenic mechanisms. Interleukin-1β as a pro-inflammatory main cytokine, can be found in this both diseases. Gingival crevicular fluid (GCF) derived from the serum of gingival sulcus, affected by inflammatory mechanism and the amount of this fluid will increase in that situation. Objective: To analyze the relationship of interleukin-1β levels in gingival crevicular fluid (GCF) of CHD and non-CHD patients with periodontal status. Methods: Oral clinical examination (plaque index, bleeding on probing, pocket depth and clinical attachment loss) for 35 subjects with CHD and 35 non CHD were checked, laboratory test to measure the levels of Interleukin-1β was checked with enzyme-linked immunosorbent assay (ELISA). Results: There was no significant differences between interleukin-1β levels in CHD and non-CHD patients (p>0.05); there was no significant difference between the level of Interleukin-1β with periodontal status in CHD and control (non CHD) patients (p>0.05). Conclusions: levels of Interleukin-1β in CHD patients do not have a relationships with plaque index, pocket depth and clinical attachment loss, but has a relationships with bleeding on probing.

  20. Volatile anesthetic for the control of posthypoxic refractory myoclonic status

    Directory of Open Access Journals (Sweden)

    Vivek Rayadurg

    2016-01-01

    Full Text Available Posthypoxic myoclonus (Lance-Adams syndrome is characterized by myoclonus involving multiple muscle groups which is resistant to most conventional antiepileptic drugs. We present a case of hypoxic brain injury-induced myoclonic status epilepticus successfully controlled with isoflurane. The antimyoclonic effects of isoflurane are likely due to potentiation of inhibitory postsynaptic GABA A receptor-mediated currents and its effects on thalamocortical pathways. It is effective even when intravenous agents fail to control myoclonus. It may be a useful alternative to intravenous anesthetics as a third tier therapy in patients with refractory status myoclonus.

  1. ER fluid applications to vibration control devices and an adaptive neural-net controller

    Science.gov (United States)

    Morishita, Shin; Ura, Tamaki

    1993-07-01

    Four applications of electrorheological (ER) fluid to vibration control actuators and an adaptive neural-net control system suitable for the controller of ER actuators are described: a shock absorber system for automobiles, a squeeze film damper bearing for rotational machines, a dynamic damper for multidegree-of-freedom structures, and a vibration isolator. An adaptive neural-net control system composed of a forward model network for structural identification and a controller network is introduced for the control system of these ER actuators. As an example study of intelligent vibration control systems, an experiment was performed in which the ER dynamic damper was attached to a beam structure and controlled by the present neural-net controller so that the vibration in several modes of the beam was reduced with a single dynamic damper.

  2. Reliable Actuator for Cryo Propellant Fluid Control Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Fluid handling applications in cryogenic and extreme environments require reliable actuation technology that can handle extreme temperatures, mechanical bind-up from...

  3. Controlling Subsurface Fractures and Fluid Flow: A Basic Research Agenda

    Energy Technology Data Exchange (ETDEWEB)

    Pyrak-Nolte, Laura J [Purdue Univ., West Lafayette, IN (United States); DePaolo, Donald J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States); Pietraß, Tanja [USDOE Office of Science, Washington, DC (United States)

    2015-05-22

    From beneath the surface of the earth, we currently obtain about 80-percent of the energy our nation consumes each year. In the future we have the potential to generate billions of watts of electrical power from clean, green, geothermal energy sources. Our planet’s subsurface can also serve as a reservoir for storing energy produced from intermittent sources such as wind and solar, and it could provide safe, long-term storage of excess carbon dioxide, energy waste products and other hazardous materials. However, it is impossible to underestimate the complexities of the subsurface world. These complexities challenge our ability to acquire the scientific knowledge needed for the efficient and safe exploitation of its resources. To more effectively harness subsurface resources while mitigating the impacts of developing and using these resources, the U.S. Department of Energy established SubTER – the Subsurface Technology and Engineering RD&D Crosscut team. This DOE multi-office team engaged scientists and engineers from the national laboratories to assess and make recommendations for improving energy-related subsurface engineering. The SubTER team produced a plan with the overall objective of “adaptive control of subsurface fractures and fluid flow.”This plan revolved around four core technological pillars—Intelligent Wellbore Systems that sustain the integrity of the wellbore environment; Subsurface Stress and Induced Seismicity programs that guide and optimize sustainable energy strategies while reducing the risks associated with subsurface injections; Permeability Manipulation studies that improve methods of enhancing, impeding and eliminating fluid flow; and New Subsurface Signals that transform our ability to see into and characterize subsurface systems. The SubTER team developed an extensive R&D plan for advancing technologies within these four core pillars and also identified several areas where new technologies would require additional basic research

  4. Usefulness of ultrasound examination in the evaluation of a neonate’s body fluid status

    Directory of Open Access Journals (Sweden)

    Joanna Kieliszczyk

    2016-06-01

    fluid status in this pediatric age group, particularly in preterm newborns, was noted due to its painless and non-invasive nature as well as easy access to equipment at neonatology wards.

  5. Effect of chronic periodontitis on serum and gingival crevicular fluid oxidant and antioxidant status in patients with familial Mediterranean fever before and after periodontal treatment.

    Science.gov (United States)

    Bostanci, Vildan; Toker, Hulya; Senel, Soner; Ozdemir, Hakan; Aydin, Huseyin

    2014-05-01

    The aim of this study is to investigate the impact of periodontal status on oxidant/antioxidant status in patients with chronic periodontitis (CP) who experienced familial Mediterranean fever (FMF) and their response to non-surgical periodontal therapy. Data were obtained from 13 patients with FMF with generalized CP (FMF-CP), 15 systemically healthy patients with generalized CP, 15 systemically and periodontal healthy controls (HCs), and 14 periodontally healthy patients with FMF (FMF-HC). Each participant's total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in their gingival crevicular fluid (GCF) and serum were recorded. Probing depth, clinical attachment level, and gingival and plaque indices in each participant were also measured. The GCF and clinical parameters at baseline and 6 weeks after periodontal treatment were recorded. The study showed statistically significant improvement of clinical parameters in both FMF-CP and CP groups after periodontal treatment. The baseline GCF-TOS and OSI levels were significantly higher in the CP group compared with the FMF-CP group (P treatment, the GCF-TOS levels were significantly reduced in members of the FMF-CP group (P 0.05). The results of the present study show that patients with FMF-CP displayed reduced oxidative stress and increased antioxidant status compared with those in the CP and HC groups.

  6. The friction control of magnetic fluid in the Couette flow

    Science.gov (United States)

    Labkovich, O. N.; Reks, A. G.; Chernobai, V. A.

    2017-06-01

    In the work characteristic areas of magnetic fluid flow are experimentally determined in the gap between the cylinders: the area of strong dipole-dipole interaction between magnetite particles 041,2. For areas with high flow losses in viscous friction is shown the possibility of reducing the introduction of magnetic fluid of carbon nanotubes and creating a rotating magnetic field.

  7. Immunosensor with fluid control mechanism for salivary cortisol analysis.

    Science.gov (United States)

    Yamaguchi, Masaki; Matsuda, Yohei; Sasaki, Shohei; Sasaki, Makoto; Kadoma, Yoshihiro; Imai, Yoshikatsu; Niwa, Daisuke; Shetty, Vivek

    2013-03-15

    The purpose of this research is to demonstrate a new design for a cortisol immunosensor for the noninvasive and quantitative analysis of salivary cortisol. We propose a cortisol immunosensor with a fluid control mechanism which has both a vertical flow and a lateral flow. The detected current resulting from a competitive reaction between the sample cortisol and a glucose oxidase (GOD)-labeled cortisol conjugate was found to be inversely related to the concentration of cortisol in the sample solution. A calibration curve using the relative detected current showed a R(2)=0.98 and CV=14% for a range of standard cortisol solutions corresponding to the concentrations of native salivary cortisol (0.1-10 ng/ml). The measurement could be accomplished within 35 min and the cortisol immunosensor could be reused. These results show promise for realizing an on-site and easy-to-use biosensor for cortisol. Used for evaluation of human salivary cortisol levels, the cortisol immunosensor measurement corresponded closely with commercially available ELISA method (R(2)=0.92). Our results indicate the promise of the new cortisol immunosensor for noninvasive, point of care measurement of human salivary cortisol levels.

  8. School Socioeconomic Status and Teacher Pupil Control Behavior

    Science.gov (United States)

    Brown, Lorraine Hayes; And Others

    1974-01-01

    Despite contrary evidence in the literature, this experimental investigation found that race and the interaction of race and socioeconomic status of students do not have a significant effect on teacher "pupil control behavior." Alternative explanations for these findings are discussed. (EH)

  9. The Nuclotron and Nica control system development status

    Science.gov (United States)

    Gorbachev, E. V.; Andreev, V. A.; Kirichenko, A. E.; Monakhov, D. V.; Romanov, S. V.; Rukoyatkina, T. V.; Sedykh, G. S.; Volkov, V. I.

    2016-09-01

    The Nuclotron is a 6 GeV/n superconducting proton synchrotron operating at JINR, Dubna since 1993. It will be the core of the future accelerating complex NICA which is under construction now. The TANGO based control system of the accelerating complex is under development now. The report describes its structure, main features and present status.

  10. An exploratory study of sodium, potassium, and fluid nutrition status of tube-fed nonambulatory children with severe cerebral palsy.

    Science.gov (United States)

    McGowan, Joan Elizabeth; Fenton, Tanis R; Wade, Andrew William; Branton, Jodi Lynn; Robertson, Marli

    2012-08-01

    Children with severe cerebral palsy (CP) often have lower mineral intakes than healthy children. It is unknown if their lower nutrient intakes are adequate to meet their needs. The objective of this study was to examine the sodium, potassium, phosphate, and fluid status of primarily tube-fed nonambulatory children with severe CP. The design consisted of a cross-sectional exploratory study and a clinical trial of sodium supplementation. Nutritional status was determined among primarily tube-fed children (aged 2 to 17 years) with CP based on blood and urine samples, anthropometry, and 3-day food records. Mineral and fluid status was evaluated by a nephrologist blind to nutrient intakes. Twenty children supplied food records, blood samples, and anthropometric measurements, and 16 supplied urine samples. Six (37.5%) of those who provided urine samples were considered possibly dehydrated, as urine osmolality was >600 mmol·kg(-1). Six (60%) of the 10 children with satisfactory fluid status (low urine osmolality) were considered to have a possible dietary sodium deficiency based on a very low urine sodium concentration (<20 mmol·L(-1)). Those considered to have a possible dietary sodium deficiency had a significantly lower sodium intake (48% ± 15% Adequate Intake (AI)) compared with those considered sodium sufficient (73% ± 20% AI) (p = 0.031). One child was considered possibly phosphorus deficient, but none was assessed as likely potassium deficient. The conclusion was that sodium deficiencies were likely prevalent among the children. The findings from this small observational study suggest that sodium intakes for tube-fed children with CP should be maintained near the AI for their age. Hydration status of children receiving hypercaloric formulas should be monitored.

  11. A randomized controlled pilot study of outcomes of strict allowance of fluid therapy in hyponatremic heart failure (SALT-HF).

    Science.gov (United States)

    Albert, Nancy M; Nutter, Benjamin; Forney, Jennifer; Slifcak, Ellen; Tang, W H Wilson

    2013-01-01

    Currently, fluid restriction recommendations in heart failure (HF) are based on expert opinion. After implementing a 1,000-mL/d fluid restriction for 60 days after discharge, outcomes were examined. In a randomized controlled design, hyponatremic patients (serum sodium ≤137 mg/dL) received usual care (UC; n = 26) or 1,000 mL/d fluid restriction (n = 20) at discharge. Quality of life (QoL), thirst, difficulty following fluid recommendations, adherence to fluid restriction, HF emergency care, HF rehospitalization, and all-cause death were examined. Mean age was 62.8 ± 12.8 years; 46% were white. There were no differences by group in baseline demographics, comorbidities, and QoL, except that more UC patients had New York Heart Association (NYHA) functional class III/IV status (P = .019). Median [interquartile range] QoL scores were better in the 1,000 mL/d group for symptom burden (83.3 [68.8-91.7] vs 50 [29.2-79.2]; P = .018), total symptoms (77.1 [58.1-91.7] vs 54.2 [30.2-73.9]; P = .022), overall QoL summary (72.6 [52.2-86.3] vs 51.0 [37.7-68.5]; P = .038), and clinical QoL summary (75.5 [57.8-92.9] vs 59.1 [35.7-77.3]; P = .039). There were no group differences in thirst, difficulty adhering to fluid recommendations, adherence to fluid restriction, or health care consumption. The 1,000 mL/d fluid restriction led to improved QoL at 60 days after discharge. Future research in a larger more heterogeneous sample is needed. Copyright © 2013 Elsevier Inc. All rights reserved.

  12. Position feedback control of a nonmagnetic body levitated in magnetic fluid

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J H; Nam, Y J; Park, M K [Graduate School, Pusan National University, Busan 609-735 (Korea, Republic of); Yamane, R [Kokushikan University, Tokyo 154-8515 (Japan)], E-mail: magooro@pusan.ac.kr

    2009-02-01

    This paper is concerned with the position feedback control of a magnetic fluid actuator which is characterized by the passive levitation of a nonmagnetic body immersed in a magnetic fluid under magnetic fields. First of all, the magnetic fluid actuator is designed based on the ferrohydrostatic relation. After manufacturing the actuator, its static and dynamic characteristics are investigated experimentally. With the aid of the dynamic governing relation obtained experimentally and the proportional-derivative controller, the position tracking control of the actuator is carried out both theoretically and experimentally. As a result, the applicability of the proposed magnetic fluid actuator to various engineering devices is verified.

  13. ERPs evidence for the relationship between fluid intelligence and cognitive control.

    Science.gov (United States)

    Lu, Di; Zhang, Haoyun; Kang, Chunyan; Guo, Taomei

    2016-04-13

    The relationship between two components of cognitive control, that is, proactive control and reactive control, and fluid intelligence was investigated by measuring 75 participants' event-related potentials in the AX version of the continuous performance test. The results showed that the mean amplitudes of N2 associated with the two components of cognitive control are highly correlated with fluid intelligence. Specifically, a larger N2 was shown in participants with higher fluid intelligence scores. No significant correlation was found in the peak latencies of the N2 and fluid intelligence. These results enrich our understanding of the relationship between cognitive control and fluid intelligence by using the N2 component as an index and also indicate that cognitive control may be a component of intelligence.

  14. Phase-controlled bistability of a dark soliton train in a polariton fluid

    CERN Document Server

    Goblot, Valentin; Carusotto, Iacopo; Galopin, Elisabeth; Lemaître, Aristide; Sagnes, Isabelle; Amo, Alberto; Bloch, Jacqueline

    2016-01-01

    We use a one-dimensional polariton fluid in a semiconductor microcavity to explore the rich nonlinear dynamics of counter-propagating interacting Bose fluids. The intrinsically driven-dissipative nature of the polariton fluid allows to use resonant pumping to impose a phase twist across the fluid. When the polariton-polariton interaction energy becomes comparable to their kinetic energy, linear interference fringes transform into a train of solitons. A novel type of bistable behavior controlled by the phase twist across the fluid is experimentally evidenced.

  15. Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology.

    Science.gov (United States)

    Burgos, Kasandra; Malenica, Ivana; Metpally, Raghu; Courtright, Amanda; Rakela, Benjamin; Beach, Thomas; Shill, Holly; Adler, Charles; Sabbagh, Marwan; Villa, Stephen; Tembe, Waibhav; Craig, David; Van Keuren-Jensen, Kendall

    2014-01-01

    The discovery and reliable detection of markers for neurodegenerative diseases have been complicated by the inaccessibility of the diseased tissue--such as the inability to biopsy or test tissue from the central nervous system directly. RNAs originating from hard to access tissues, such as neurons within the brain and spinal cord, have the potential to get to the periphery where they can be detected non-invasively. The formation and extracellular release of microvesicles and RNA binding proteins have been found to carry RNA from cells of the central nervous system to the periphery and protect the RNA from degradation. Extracellular miRNAs detectable in peripheral circulation can provide information about cellular changes associated with human health and disease. In order to associate miRNA signals present in cell-free peripheral biofluids with neurodegenerative disease status of patients with Alzheimer's and Parkinson's diseases, we assessed the miRNA content in cerebrospinal fluid and serum from postmortem subjects with full neuropathology evaluations. We profiled the miRNA content from 69 patients with Alzheimer's disease, 67 with Parkinson's disease and 78 neurologically normal controls using next generation small RNA sequencing (NGS). We report the average abundance of each detected miRNA in cerebrospinal fluid and in serum and describe 13 novel miRNAs that were identified. We correlated changes in miRNA expression with aspects of disease severity such as Braak stage, dementia status, plaque and tangle densities, and the presence and severity of Lewy body pathology. Many of the differentially expressed miRNAs detected in peripheral cell-free cerebrospinal fluid and serum were previously reported in the literature to be deregulated in brain tissue from patients with neurodegenerative disease. These data indicate that extracellular miRNAs detectable in the cerebrospinal fluid and serum are reflective of cell-based changes in pathology and can be used to assess

  16. Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology.

    Directory of Open Access Journals (Sweden)

    Kasandra Burgos

    Full Text Available The discovery and reliable detection of markers for neurodegenerative diseases have been complicated by the inaccessibility of the diseased tissue--such as the inability to biopsy or test tissue from the central nervous system directly. RNAs originating from hard to access tissues, such as neurons within the brain and spinal cord, have the potential to get to the periphery where they can be detected non-invasively. The formation and extracellular release of microvesicles and RNA binding proteins have been found to carry RNA from cells of the central nervous system to the periphery and protect the RNA from degradation. Extracellular miRNAs detectable in peripheral circulation can provide information about cellular changes associated with human health and disease. In order to associate miRNA signals present in cell-free peripheral biofluids with neurodegenerative disease status of patients with Alzheimer's and Parkinson's diseases, we assessed the miRNA content in cerebrospinal fluid and serum from postmortem subjects with full neuropathology evaluations. We profiled the miRNA content from 69 patients with Alzheimer's disease, 67 with Parkinson's disease and 78 neurologically normal controls using next generation small RNA sequencing (NGS. We report the average abundance of each detected miRNA in cerebrospinal fluid and in serum and describe 13 novel miRNAs that were identified. We correlated changes in miRNA expression with aspects of disease severity such as Braak stage, dementia status, plaque and tangle densities, and the presence and severity of Lewy body pathology. Many of the differentially expressed miRNAs detected in peripheral cell-free cerebrospinal fluid and serum were previously reported in the literature to be deregulated in brain tissue from patients with neurodegenerative disease. These data indicate that extracellular miRNAs detectable in the cerebrospinal fluid and serum are reflective of cell-based changes in pathology and can

  17. Reliable Actuator for Cryo Propellant Fluid Control Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Cryogenic fluid handling applications require a reliable actuation technology that can handle very low temperatures. A novel EM hammer drive technology is proposed...

  18. Cardiovascular and fluid volume control in humans in space

    DEFF Research Database (Denmark)

    Norsk, Peter

    2005-01-01

    The human cardiovascular system and regulation of fluid volume are heavily influenced by gravity. When decreasing the effects of gravity in humans such as by anti-orthostatic posture changes or immersion into water, venous return is increased by some 25%. This leads to central blood volume expans...... is of importance for understanding pathophysiology of heart failure, where gravity plays a strong role in fluid and sodium retention.......The human cardiovascular system and regulation of fluid volume are heavily influenced by gravity. When decreasing the effects of gravity in humans such as by anti-orthostatic posture changes or immersion into water, venous return is increased by some 25%. This leads to central blood volume...... on this complex interaction, because it is the only way to completely abolish the effects of gravity over longer periods. Results from space have been unexpected, because astronauts exhibit a fluid and sodium retaining state with activation of the sympathetic nervous system, which subjects during simulations...

  19. Contamination Control and Monitoring of Tap Water as Fluid in Industrial Tap Water Hydraulic Systems

    DEFF Research Database (Denmark)

    Conrad, Finn; Adelstorp, Anders

    1998-01-01

    Presentation of results and methods addressed to contamination control and monitoring of tap water as fluid in tap water hydraulic systems.......Presentation of results and methods addressed to contamination control and monitoring of tap water as fluid in tap water hydraulic systems....

  20. Contamination Control and Monitoring of Tap Water as Fluid in Industrial Tap Water Hydraulic Systems

    DEFF Research Database (Denmark)

    Conrad, Finn; Adelstorp, Anders

    1998-01-01

    Presentation of results and methods addressed to contamination control and monitoring of tap water as fluid in tap water hydraulic systems.......Presentation of results and methods addressed to contamination control and monitoring of tap water as fluid in tap water hydraulic systems....

  1. Follicular fluid lipid peroxidation levels in women with endometriosis during controlled ovarian hyperstimulation.

    Science.gov (United States)

    de Lima, Camila Bruna; Cordeiro, Fernanda Bertuccez; Camargo, Mariana; Zylbersztejn, Daniel Suslik; Cedenho, Agnaldo Pereira; Bertolla, Ricardo Pimenta; Lo Turco, Edson Guimarães

    2017-04-01

    This observational study aimed to establishing a relationship between lipid peroxidation and endometriosis in women undergoing controlled ovarian hyperstimulation. A total of 79 women were divided into two groups: (i) controls (tubal or male factor); and (ii) endometriosis (stages III/IV). The endometriosis diagnosis was confirmed by videolaparoscopy and the controlled ovarian stimulation protocol was similar to all patients. Follicular fluid (FF) lipid peroxidation levels were determined through the quantification of malondialdehyde. Statistical analysis was performed using parametric and non-parametric tests, logistic regression was performed to estimate the chance of achieving a pregnancy in each group and a moving average was calculated for the endometriosis group. Peroxidation levels in the endometriosis group were significantly higher when compared to controls. The moving average showed a decrease of MDA levels in the endometriosis group with increasing female age. Moreover, women with endometriosis who were under 33 years of age were 4.3 times more likely to achieve a pregnancy than women above that age. In conclusion, endometriosis is associated with increased FF oxidative stress (OS) in patients undergoing in vitro fertilization (IVF). Also, increasing age is associated with a decrease in severity of the oxidative status, but a decreased chance of pregnancy.

  2. Simulation and control scheme of microstructure in magnetic fluids

    Institute of Scientific and Technical Information of China (English)

    LI Qiang; XUAN YiMin; LI Bin

    2007-01-01

    By accounting for the external and internal force acting on the suspended magnetic nanoparticles and motion characteristics of the suspended magnetic nanoparticles in the magnetic fluids, the three-dimensional microstructure of magnetic fluids is investigated by means of the molecular dynamics simulation method. The distribution of suspended magnetic nanoparticles and microstructure of the magnetic fluid are simulated in both absence and presence of an external magnetic field. The effecta of the nanoparticles volume fraction, the dipole-dipole interaction potential and the particle-field interaction potential on the microstructures of the magnetic fluids are discussed. The main results obtained here are summarized as follows.The suspended magnetic nanoparticles tend to aggregate and make the irregular distribution structure in the absence of an external magnetic field. When the magnetic fluid is exposed to a magnetic field, the magnetic nanoparticles suspended in the carrier fluid tend to remain chained-alignment in the direction of the external magnetic field. The tendency of chain-alignment morphology of the suspended magnetic nanoparticles is enhanced with the nanoparticles volume fraction, the dipole-dipole interaction potential and the particle-field interaction potential.

  3. Simulation and control scheme of microstructure in magnetic fluids

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    By accounting for the external and internal force acting on the suspended magnetic nanoparticles and motion characteristics of the suspended magnetic nanoparticles in the magnetic fluids,the three-dimensional microstructure of magnetic fluids is investigated by means of the molecular dynamics simulation method. The distribu-tion of suspended magnetic nanoparticles and microstructure of the magnetic fluid are simulated in both absence and presence of an external magnetic field. The ef-fects of the nanoparticles volume fraction,the dipole-dipole interaction potential and the particle-field interaction potential on the microstructures of the magnetic fluids are discussed. The main results obtained here are summarized as follows. The suspended magnetic nanoparticles tend to aggregate and make the irregular distribution structure in the absence of an external magnetic field. When the mag-netic fluid is exposed to a magnetic field,the magnetic nanoparticles suspended in the carrier fluid tend to remain chained-alignment in the direction of the external magnetic field. The tendency of chain-alignment morphology of the suspended magnetic nanoparticles is enhanced with the nanoparticles volume fraction,the dipole-dipole interaction potential and the particle-field interaction potential.

  4. Pediatric diabetic ketoacidosis, fluid therapy, and cerebral injury: the design of a factorial randomized controlled trial.

    Science.gov (United States)

    Glaser, Nicole S; Ghetti, Simona; Casper, T Charles; Dean, J Michael; Kuppermann, Nathan

    2013-09-01

    Treatment protocols for pediatric diabetic ketoacidosis (DKA) vary considerably among centers in the USA and worldwide. The optimal protocol for intravenous (IV) fluid administration is an area of particular controversy, mainly in regard to possible associations between rates of IV fluid infusion and the development of cerebral edema (CE), the most common and the most feared complication of DKA in children. Theoretical concerns about associations between osmotic fluid shifts and CE have prompted recommendations for conservative fluid infusion during DKA. However, recent data suggest that cerebral hypoperfusion may play a role in cerebral injury associated with DKA. Currently, there are no existing data from prospective clinical trials to determine the optimal fluid treatment protocol for pediatric DKA. The Pediatric Emergency Care Applied Research Network FLUID (FLuid therapies Under Investigation in DKA) study is the first prospective randomized trial to evaluate fluid regimens for pediatric DKA. This 13-center nationwide factorial design study will evaluate the effects of rehydration rate and fluid sodium content on neurological status during DKA treatment, the frequency of clinically overt CE and long-term neurocognitive outcomes following DKA.

  5. Effectiveness of Nitrous Oxide as a Liquid Injection Thrust Vector Control Fluid Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Nitrous Oxide is proposed as an energetic liquid injection thrust vector control fluid for vehicle attitude control during dynamic vehicle maneuvers. Pulled from the...

  6. The status and latest issues on KAERI export control implementation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Sook; Park, Ho Jun; Kim, Hyun Jo; Ko, Han Suk; Lee, Byung Doo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2010-10-15

    There are four informal non-proliferation arrangements which seek to control the proliferation of weapons of mass destruction and their missile delivery systems and the transfer of conventional weapons and dual-use technologies. The four arrangements are Wassenaar Arrangement (WA) on export controls for conventional arms and dual use goods and technologies, Nuclear Supplies Group(NSG), Missile Technology Control Regime(MTCR) and Australia Group(AG) on chemical and biological weapons materials. ROK participates in four arrangements to seek to encourage responsible practice in the trade of strategic goods and technologies. It is achieved through the implementation of export control list. MKE Notification (Ministry of Knowledge Economy Notification No. 2009-250) specifies those items and technologies subject to control. In this paper, the status and latest issues on KAERI export control implementation are described

  7. Immune status, antibiotic medication and pH are associated with changes in the stomach fluid microbiota.

    Science.gov (United States)

    von Rosenvinge, Erik C; Song, Yang; White, James R; Maddox, Cynthia; Blanchard, Thomas; Fricke, W Florian

    2013-07-01

    The stomach acts as a barrier to ingested microbes, thereby influencing the microbial ecology of the entire gastrointestinal (GI) tract. The stomach microbiota and the role of human host and environmental factors, such as health status or medications, in shaping its composition remain largely unknown. We sought to characterize the bacterial and fungal microbiota in the stomach fluid in order to gain insights into the role of the stomach in GI homeostasis. Gastric fluid was collected from 25 patients undergoing clinically indicated upper endoscopy. DNA isolates were used for PCR amplification of bacterial 16S ribosomal RNA (rRNA) genes and fungal internal transcribed spacers (ITS). RNA isolates were used for 16S rRNA cDNA generation and subsequent PCR amplification. While all stomach fluid samples are dominated by the phyla Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria and Fusobacteria (>99% of sequence reads), the transcriptionally active microbiota shows significant reduction in Actinobacteria (34%) and increase in Campylobacter (444%) (PBacterial but not fungal diversity is reduced by antibiotic treatment (28%; P4 (70%; Pmicrobiota, using bacterial 16S rRNA gene and transcript, and fungal ITS amplicon sequencing and provide evidence for a significant impact of the host immune status on its composition with likely consequences for human health.

  8. Physiological, Behavioral, and Scientific Impact of Different Fluid Control Protocols in the Rhesus Macaque (Macaca mulatta)

    Science.gov (United States)

    Bertrand, Henri; Mindus, Claire; Flecknell, Paul

    2016-01-01

    Abstract Rhesus macaques are an important model in behavioral neuroscience due to their advanced cognitive abilities. To motivate animals to engage in complex tasks, fluid rewards, in conjunction with fluid control protocols, are often used. The impact of these protocols on animal welfare is controversial. We compared two fluid control protocols against a protocol providing free access to water and evaluated the impacts on physiological states of hydration, behavioral measures of welfare, and scientific output. Blood physiology did not significantly differ between any of the protocols, and urine measures were indicative of well functioning, healthy kidneys. Changes in behaviors were limited, the main one being an increase in motivation to drink on the stricter fluid control protocol, and improved task performance early in the week. Overall, fluid control protocols had little measurable impact on the welfare of rhesus macaques while ensuring that scientific data of high quality could be obtained. PMID:27679812

  9. VIBRATION CONTROL OF FLUID- FILLED PRISMATIC SHELL WITH ACTIVE CONSTRAINED LAYER DAMPING TREATMENTS

    Institute of Scientific and Technical Information of China (English)

    LIU Lijun; ZHANG Zhiyi; HUA Hongxing; ZHANG Yi

    2008-01-01

    Active constrained layer damping (ACLD) combines the simplicity and reliability of passive damping with the light weight and high efficiency of active actuators to obtain high damping over a wide frequency band. A fluid-filled prismatic shell is set up to investigate the validity and efficiency of ACLD treatments in the case of fluid-structure interaction. By using state subspace identification method, modal parameters of the ACLD system are identified and a state space model is established subsequently for the design of active control laws. Experiments are conducted to the fluid-filled prismatic shell subjected to random and impulse excitation, respectively. For comparison, the shell model without fluid interaction is experimented as well. Experimental results have shown that the ACLD treatments can suppress vibration of the fluid-free and fluid-filled prismatic shell effectively. Under the same control gain, vibration attenuation is almost the same in both cases.

  10. [The status of acid-base homeostasis in oral fluid during gestation].

    Science.gov (United States)

    Pol'ovyĭ, P V

    2013-01-01

    The article presents information on the nature and dynamics of metabolic changes in oral fluid in women during gestation. It is shown that dystrophic-inflammatory processes of periodontal tissues grow backed by the progression of metabolic acidosis. High content of sulfhydryl groups and disulfide ties in soluble proteins and low molecular weight compounds of oral fluid during pregnancy and activation of enzymatic antioxidant defense system periodontal tissues are found.

  11. Using artificial intelligence to control fluid flow computations

    Science.gov (United States)

    Gelsey, Andrew

    1992-01-01

    Computational simulation is an essential tool for the prediction of fluid flow. Many powerful simulation programs exist today. However, using these programs to reliably analyze fluid flow and other physical situations requires considerable human effort and expertise to set up a simulation, determine whether the output makes sense, and repeatedly run the simulation with different inputs until a satisfactory result is achieved. Automating this process is not only of considerable practical importance but will also significantly advance basic artificial intelligence (AI) research in reasoning about the physical world.

  12. Presence of crevicular fluid Prostaglandin E2 in relation with clinical and radiographic periodontal status

    Directory of Open Access Journals (Sweden)

    Javier Elpidio Monzón

    2016-07-01

    Full Text Available Background and Objectives: Prostaglandin E2 (PGE2 is present in gingival crevicular fluid the (GCF and is evidenced in periodontal disease (PD. However, there are no enough reports to correlate the PGE2 concentrations in GCF in periodontal health and disease with clinical and radiographic indicators, age and gender. Hence, the present study is aimed to estimate the levels of PGE2 in GCF of subjects without periodontal disease (SEP and periodontal disease (CEP. Materials and Methods: 99 subjects were selected, 33 without PD (G1 and 66 with PD, 33 with gingivitis (G2 and 33 with periodontitis (G3, which were submitted to a clinical and radiographic diagnosis, registering samples FGC, being stored, centrifuged and refrigerated for preservation. Subsequently the concentration of crevicular PGE2 was measured by using the enzyme linked immunosorbent assay (ELISA, determining the concentration of each subject. Results: PGE2 was detected in all the samples. The G1 presented a concentration of 28.82 ± 2.88 pg / mL, G2 44.91 ± 4.37 pg / mL and G3 148.67 ± 74.74 pg / mL (0.0001. PGE2 levels were significantly correlated with bleeding on probing, probing depth, attachment loss and bone loss (0.05. PGE2 levels were modified by age, but not gender. Conclusion: It is well known that activated inflammatory cells produce inflammatory mediators that stimulate the production of PGE2. The findings of this study demonstrate an increased concentration of PGE2 in FCG according to the presence of greater severity of PD. PGE2 may be considered as a biomarker in PD progression. However, controlled, longitudinal studies are needed to confirm this possibility.

  13. Prospects for Computational Fluid Dynamics in Room Air Contaminant Control

    DEFF Research Database (Denmark)

    Nielsen, Peter V.

    The fluid dynamics research is strongly influenced by the increasing computer power which has been available for the last decades. This development is obvious from the curve in figure 1 which shows the computation cost as a function of years. It is obvious that the cost for a given job...

  14. Control of Low Reynolds Number Flows with Fluid Structure Interactions

    Science.gov (United States)

    2014-02-02

    public release; distribution is unlimited. 27 the direct numerical simulations of Andro and Jacquin [37] for a plunging NACA 0012 airfoil at Re...34Bifurcating Flows of Plunging Airfoils at High Strouhal Numbers," Journal of Fluid Mechanics, Vol. 708, 2012, pp. 349-376. [37] Andro , J.Y

  15. STUDY ON FLUID THICKNESS BETWEEN POPPET AND VALVE GUIDE IN CONTROL VALVE OF INJECTOR

    Institute of Scientific and Technical Information of China (English)

    Zhang Jianming; Zhang Weigang; Wang Yawei

    2004-01-01

    The physical model of -20 diesel oil and force model of injector control valve of common rail system is built. The changes of the fluid thickness are investigated on the base of the results of CFD and experiments for control valve of injector. The results indicate that a fluid thickness of 0.02~0.03 mm between the poppet and valve guide is sufficient to dampen any excessive control valve poppet bouncing.

  16. Single Neuron PID Control of Aircraft Deicing Fluids Rapid Heating System

    OpenAIRE

    2013-01-01

    Aircraft deicing fluids rapid heating system is widely used in aircraft ground deicing to ensure that the operation of flights can be safe and efficient. Aiming at the temperature turbulence problem of aircraft deicing system, this paper presents the single neuron PID control strategy which combine the advantage of conventional PID control with artificial neuron control. The aircraft deicing fluids rapid heating system and the scheme and working principle of the system is introduced. Simulati...

  17. Fluid-controlled rheological responses during intraplate orogeny

    Science.gov (United States)

    Raimondo, Tom; Howlett, Daniel; Hand, Martin; Clark, Chris

    2016-04-01

    The intraplate Alice Springs Orogen, central Australia, is characterised by fluid-rock systems that systematically vary in their depth, structural style, fluid sources and magnitude of rehydration and reworking. Discrete metre-scale cataclastic faults in the northwestern Reynolds-Anmatjira Ranges progress into ten- to hundred metre-scale metasomatised shear zones at the southeastern margin of this terrane, associated with low δ18O and δD values indicative of a meteoric fluid source. Continuing along strike to the southeast, these structures are succeeded by kilometre-scale schist belts transecting Palaeoproterozoic granulites in the Strangways Metamorphic Complex, followed by a ˜7500 km2 zone of pervasive Palaeozoic amphibolite facies retrogression and voluminous partial melting in the Harts Range and Entia Gneiss Complex further east. Strongly deformed outcrops of the basal sedimentary unit of the Amadeus Basin (Heavitree Quartzite) are preserved in these areas, and discrete shifts to elevated δ18O values suggest that shear zones of the Strangways Metamorphic Complex contain fluids sourced from its prograde dewatering. Intriguingly, despite being part of a laterally-continuous, anastomosing shear belt that forms the dominant structural network of the Alice Springs Orogen, the fluid-rock systems described above appear to be diachronous. Garnet Sm-Nd and monazite U-Pb geochronology from garnet-staurolite-biotite-muscovite-quartz ± kyanite ± sillimanite schists of the Strangways Metamorphic Complex indicate metamorphic ages of ca 445 Ma, ca 380 Ma, ca 360 Ma and ca 330 Ma, spanning approximately 120 Myr of fluid-rock interaction and partial melting. P-T evolutions constrained by petrography, EPMA X-ray maps and calculated pseudosections also demonstrate multiple prograde thermal cycles across this interval, while field relationships indicate the reactivation of contractional structures by overprinting extensional ultramylonites, attesting to a prolonged and

  18. Controller Development for a Separate Meter-In Separate Meter-Out Fluid Power Valve for Mobile Applications

    DEFF Research Database (Denmark)

    Nielsen, Brian

    by a single pump the fluid is distributed through valves. A valve works by controlling a fluid stream through the valve by varying the opening of an orifice. The disadvantage by this is that when controlling the fluid flow rate a pressure drop is created across the orifice. This results in a throttle loss......, which is commonly used in many types of mobile applications, is a 4-way proportional valve. In this type of valve two fluid streams are controlled: One fluid stream from a pump to a fluid consumer and one fluid stream from the fluid consumer to a fluid reservoir. In a 4-way proportional valve...... it is necessary to use a separate control of the two fluid streams to minimise the throttling losses. The purpose of the research documented in this dissertation is to investigate how a 4-way proportional valve may be build to fulfil the increasing demands with regard to energy efficiency and functionality...

  19. Control of mechatronic systems using electrorheological fluids; ER ryutai wo mochiita mekatoronikusu kiki no seigyo

    Energy Technology Data Exchange (ETDEWEB)

    Furusho, J. [The Univ. of Electric Communications, Tokyo (Japan)

    1995-09-10

    ER fluids (electrorheological fluids) are fluids whose rheological properties vary due to an electric field, and at the present, its development is being vigorously carried forward with the objective of its application to various mechanical systems. The ER fluids which are the objects for its development are two kinds, namely ER suspensions and homogeneous fluids using liquid crystals. Concerning the ER suspensions, its study started from the latter half of 1940`s, but the history of studying the homogeneous ER fluids is short. In this article, comparison is made between the ER suspensions and the homogeneous ER fluids. Regarding the comparison in their application fields, several differences are enumerated including that the response time of the ER suspensions to the change of the electric field is considerably faster than the homogeneous fluids using liquid crystals. As examples of the application of the ER suspensions, ER valves, application to automobiles, ER dampers, vibration control of structures, and ER clutches are shown and likewise, as examples of the application of the homogeneous ER fluids, robot arm control, dampers, etc.. Also its application to robotics is described. 51 refs., 8 figs., 1 tab.

  20. Analysis of scientific truth status in controlled rehabilitation trials.

    Science.gov (United States)

    Kerry, Roger; Madouasse, Aurélien; Arthur, Antony; Mumford, Stephen D

    2013-08-01

    Systematic reviews, meta-analyses and clinical guidelines (reviews) are intended to inform clinical practice, and in this sense can be thought of as scientific truthmakers. High-quality controlled trials should align to this truth, and method quality markers should predict truth status. We sought to determine in what way controlled trial quality relates to scientific truth, and to determine predictive utility of trial quality and bibliographic markers. A sample of reviews in rehabilitation medicine was examined. Two scientific truth dimensions were established based on review outcomes. Quality and bibliographic markers were extracted from associated trials for use in a regression analysis of their predictive utility for trial truth status. Probability analysis was undertaken to examine judgments of future trial truth status. Of the 93 trials included in contemporaneous reviews, overall, n = 45 (48%) were true. Randomization was found more in true trials than false trials in one truth dimension (P = 0.03). Intention-to-treat analysis was close to significant in one truth dimension (P = 0.058), being more commonly used in false trials. There were no other significant differences in quality or bibliographic variables between true and false trials. Regression analysis revealed no significant predictors of trial truth status. Probability analysis reported that the reasonable chance of future trials being true was between 2 and 5%, based on a uniform prior. The findings are at odds with what is considered gold-standard research methods, but in line with previous reports. Further work should focus on scientific dynamics within healthcare research and evidence-based practice constructs. © 2012 John Wiley & Sons Ltd.

  1. Establishment of a Cutting Fluid Control System (Phase III)

    Science.gov (United States)

    1982-09-01

    usually takes two to five days. If a crystalline or extremely gummy residue is formed, this fluid should be discarded from further testing. After...REFERENCES 1. "Fishtail Defects in Bearing Races - Their Origin and Elimination," C. F. Barth, TRW TM-4713, December 1972. 2. "Elimination of...Fishtail Defects in Bearing Races Through Optimized Grinding Procedures," C. F. Barth, TRW TM-4768, November 1974. 3. "fhe Nature of Surface Finish

  2. Quality control of computational fluid dynamics in indoor environments

    DEFF Research Database (Denmark)

    Sørensen, Dan Nørtoft; Nielsen, P. V.

    2003-01-01

    Computational fluid dynamics (CFD) is used routinely to predict air movement and distributions of temperature and concentrations in indoor environments. Modelling and numerical errors are inherent in such studies and must be considered when the results are presented. Here, we discuss modelling as...... the quality of CFD calculations, as well as guidelines for the minimum information that should accompany all CFD-related publications to enable a scientific judgment of the quality of the study....

  3. The Use of Postural Vital Signs in the Assessment of Fluid Volume Status.

    Science.gov (United States)

    Wandel, Jane Corrigan

    1990-01-01

    Blood pressure and pulse are measured in supine and upright positions, and certain differences between the values are said to indicate fluid volume disturbance. Most discussions of this "orthostatic test" do not explain how it should be done, and they differ from what has been observed in a practice setting. (MLW)

  4. Developments in Fluid Power Control of Machinery and Manipulators (2 of 2)

    DEFF Research Database (Denmark)

    Conrad, Finn; Sørensen, Torben; Zhou, Jianjun

    2000-01-01

    The paper reports and discusses results from a Danish mechatronic research programme focusing on intelligent actuators for motion control as well as results from the ESPRIT project SWING on IT-tools for rapid prototyping of fluid power components and systems.......The paper reports and discusses results from a Danish mechatronic research programme focusing on intelligent actuators for motion control as well as results from the ESPRIT project SWING on IT-tools for rapid prototyping of fluid power components and systems....

  5. Single Neuron PID Control of Aircraft Deicing Fluids Rapid Heating System

    Directory of Open Access Journals (Sweden)

    Bin Chen

    2013-02-01

    Full Text Available Aircraft deicing fluids rapid heating system is widely used in aircraft ground deicing to ensure that the operation of flights can be safe and efficient. Aiming at the temperature turbulence problem of aircraft deicing system, this paper presents the single neuron PID control strategy which combine the advantage of conventional PID control with artificial neuron control. The aircraft deicing fluids rapid heating system and the scheme and working principle of the system is introduced. Simulation is executed on the basis of the mathematical model of aircraft deicing fluids rapid heating system, which is built in this paper, according to a number of data collected by experiments which are operated on the experimental platform of deicing fluids rapid heating system. The simulation results show that the single neuron PID control strategy perform effectively on the temperature turbulence problem of aircraft deicing fluids rapid heating system. Experiments are conducted to vertify the single neuron PID control strategy, the results of which show that the single neuron PID control strategy can achieve the request in practical application of the aircraft deicing fluids rapid heating system.

  6. Intra-Operative Fluid Management in Adult Neurosurgical Patients Undergoing Intracranial Tumour Surgery: Randomised Control Trial Comparing Pulse Pressure Variance (PPV) and Central Venous Pressure (CVP)

    Science.gov (United States)

    Salins, Serina Ruth; Kumar, Amar Nandha; Korula, Grace

    2016-01-01

    Introduction Fluid management in neurosurgery presents specific challenges to the anaesthesiologist. Dynamic para-meters like Pulse Pressure Variation (PPV) have been used successfully to guide fluid management. Aim To compare PPV against Central Venous Pressure (CVP) in neurosurgical patients to assess hemodynamic stability and perfusion status. Materials and Methods This was a single centre prospective randomised control trial at a tertiary care centre. A total of 60 patients undergoing intracranial tumour excision in supine and lateral positions were randomised to two groups (Group 1, CVP n=30), (Group 2, PPV n=30). Intra-operative fluid management was titrated to maintain baseline CVP in Group 1(5-10cm of water) and in Group 2 fluids were given to maintain PPV less than 13%. Acid base status, vital signs and blood loss were monitored. Results Although intra-operative hypotension and acid base changes were comparable between the groups, the patients in the CVP group had more episodes of hypotension requiring fluid boluses in the first 24 hours post surgery. {CVP group median (25, 75) 2400ml (1850, 3110) versus PPV group 2100ml (1350, 2200) p=0.03} The patients in the PPV group received more fluids than the CVP group which was clinically significant. {2250 ml (1500, 3000) versus 1500ml (1200, 2000) median (25, 75) (p=0.002)}. The blood loss was not significantly different between the groups The median blood loss in the CVP group was 600ml and in the PPV group was 850 ml; p value 0.09. Conclusion PPV can be used as a reliable index to guide fluid management in neurosurgical patients undergoing tumour excision surgery in supine and lateral positions and can effectively augment CVP as a guide to fluid management. Patients in PPV group had better hemodynamic stability and less post operative fluid requirement. PMID:27437329

  7. Eutrophication status and control strategy of Taihu Lake

    Institute of Scientific and Technical Information of China (English)

    Limin ZHANG; Minfang XIA; Lei ZHANG; Chun WANG; Jilai LU

    2008-01-01

    The water quality and eutrophication status of Taihu Lake in recent years are presented and the pollution trends are analyzed. It is shown that because of unreas-onable industrial structures, pollution discharge per GDP is high within the Taihu basin, and the pollution discharge from point and-non-point sources exceed the basin's environmental carrying capacity. Especially, excessive pollutants containing nitrgogen and phosphorus are being discharged. Moreover, eutrophication may also result from internal pollution sources such as the release of nutrient elements from sediment. All these factors have resulted in-the water quality deterioration of Taihu Lake. To solve this environmental problem, possible con-trol strategies are summarized, including the control of internal pollution sources and inflow-river pollution, eco-logical restoration and reconstruction of the degraded lakeside zone ecosystem, clean water diversion, dredging, and manual algae removal.

  8. Safety System for Controlling Fluid Flow into a Suction Line

    Science.gov (United States)

    England, John Dwight (Inventor); Kelley, Anthony R. (Inventor); Cronise, Raymond J. (Inventor)

    2015-01-01

    A safety system includes a sleeve fitted within a pool's suction line at the inlet thereof. An open end of the sleeve is approximately aligned with the suction line's inlet. The sleeve terminates with a plate that resides within the suction line. The plate has holes formed therethrough. A housing defining a plurality of distinct channels is fitted in the sleeve so that the distinct channels lie within the sleeve. Each of the distinct channels has a first opening on one end thereof and a second opening on another end thereof. The second openings reside in the sleeve. Each of the distinct channels is at least approximately three feet in length. The first openings are in fluid communication with the water in the pool, and are distributed around a periphery of an area of the housing that prevents coverage of all the first openings when a human interacts therewith.

  9. Computational fluid dynamics for defect control in semiconductor processing

    Science.gov (United States)

    Kempka, S. N.; Geller, A. S.

    Finite element simulations of mixed convection flow (Re less than 100, Gr less than 10(exp 6)) are presented for two gas flow reactors characteristic of those used in the manufacture of microchips. The simulations demonstrate the usefulness of FIDAP (a finite element, Navier-Stokes code developed by Fluid Dynamics International, Inc.) as a tool to design new reactors and to assess the effects of varying operating conditions in present reactors. The calculations predict the existence of thermal plumes and recirculation regions within reactors. These flow nonuniformities are important since they can result in fatal defects in microchips. Comparisons between solutions obtained using a Boussinesq model and FIDAP's variable density model are presented. The FIDAP calculations agree with previous simulations using more detailed models, supporting the use of FIDAP as a design tool in the semiconductor industry.

  10. Long Duration Life Test of Propylene Glycol Water Based Thermal Fluid Within Thermal Control Loop

    Science.gov (United States)

    Le, Hung; Hill, Charles; Stephan, Ryan A.

    2010-01-01

    Evaluations of thermal properties and resistance to microbial growth concluded that 50% Propylene Glycol (PG)-based fluid and 50% de-ionized water mixture was desirable for use as a fluid within a vehicle s thermal control loop. However, previous testing with a commercial mixture of PG and water containing phosphate corrosion inhibitors resulted in corrosion of aluminum within the test system and instability of the test fluid. This paper describes a follow-on long duration testing and analysis of 50% Propylene Glycol (PG)-based fluid and 50% de-ionized water mixture with inorganic corrosion inhibitors used in place of phosphates. The test evaluates the long-term fluid stability and resistance to microbial and chemical changes

  11. Environmental controls on microbial communities in continental serpentinite fluids

    Directory of Open Access Journals (Sweden)

    Melitza eCrespo-Medina

    2014-11-01

    Full Text Available Geochemical reactions associated with serpentinization alter the composition of dissolved organic compounds in circulating fluids and potentially liberate mantle-derived carbon and reducing power to support subsurface microbial communities. Previous studies have identified Betaproteobacteria from the order Burkholderiales and bacteria from the order Clostridiales as key components of the serpentinite–hosted microbiome, however there is limited knowledge of their metabolic capabilities or growth characteristics. In an effort to better characterize microbial communities, their metabolism, and factors limiting their activities, microcosm experiments were designed with fluids collected from several monitoring wells at the Coast Range Ophiolite Microbial Observatory (CROMO in northern California during expeditions in March and August 2013. The incubations were initiated with a hydrogen atmosphere and a variety of carbon sources (carbon dioxide, methane, acetate and formate, with and without the addition of nutrients and electron acceptors. Growth was monitored by direct microscopic counts; DNA yield and community composition was assessed at the end of the three month incubation. For the most part, results indicate that bacterial growth was favored by the addition of acetate and methane, and that the addition of nutrients and electron acceptors had no significant effect on microbial growth, suggesting no nutrient- or oxidant-limitation. However the addition of sulfur amendments led to different community compositions. The dominant organisms at the end of the incubations were closely related to Dethiobacter sp. and to the family Comamonadaceae, which are also prominent in culture-independent gene sequencing surveys. These experiments provide one of first insights into the biogeochemical dynamics of the serpentinite subsurface environment and will facilitate experiments to trace microbial activities in serpentinizing ecosystems.

  12. Pathogen control in complex fluids with water-coupled excimer lamps at 282 and 308 nm.

    Science.gov (United States)

    Coogan, John J

    2005-01-01

    Water-coupled excimer lamp systems have been developed to inactivate microorganisms within complex, low-optical quality, fluids. Monochromatic lamps were selected to minimize UV-B and UV-C absorption within the carrier fluids while maximizing deposition within specific chemical targets. Fundamentals, system scaling and power supply design are discussed. This work used two large-surface area excimer lamps as intense sources of near monochromatic radiation at 308 and 282 nm. Data are presented for two distinct fluid systems: flow-through processing of large-volume metalworking fluids used in heavy industry and batch irradiation of human blood plasma and platelet suspensions used in transfusion medicine. In the first, a 200-600 L/min reactor is used to control bacterial concentrations within metalworking fluids used in large-scale metal machining processes. Control is defined as the maintenance of 10(3) to 10(4) CFU/mL in fluids that without treatment would have concentrations over 10(7) CFU/mL. The second is a batch process for viral inactivation in undiluted blood bank products. Samples of fresh frozen plasma and platelet suspensions were spiked with high titers of porcine parvovirus (PPV) and irradiated at 308 and 282 nm. Although both wavelengths were effective at reducing PPV levels, 308 nm light resulted in both higher rates of viral inactivation (greater than 6 log units) and lower rates of fluid degradation.

  13. Modular microfluidic systems using reversibly attached PDMS fluid control modules

    DEFF Research Database (Denmark)

    Skafte-Pedersen, Peder; Sip, Christopher G.; Folch, Albert;

    2013-01-01

    The use of soft lithography-based poly(dimethylsiloxane) (PDMS) valve systems is the dominating approach for high-density microscale fluidic control. Integrated systems enable complex flow control and large-scale integration, but lack modularity. In contrast, modular systems are attractive altern...

  14. Controlling Fluid Flow in the Subsurface through Ureolysis-Controlled Mineral Precipitation

    Science.gov (United States)

    Gerlach, R.; Phillips, A. J.; Cunningham, A. B.; Spangler, L.

    2016-12-01

    In situ urea hydrolysis has been used by us successfully to manipulate the carbonate alkalinity and control the precipitation of carbonate minerals. Urea hydrolysis can be promoted using microbial cells, enzymes or thermal energy. This technology can be used to mitigate leakage pathways, seal fractures or control fluid transport in the subsurface in hydrocarbon production, enhanced geothermal energy storage, carbon sequestration, nuclear waste disposal, etc. We have completed two field demonstrations of the urea hydrolysis-controlled in situ mineral precipitation technology. The first demonstration showed fracture sealing was possible in a sandstone formation approx. 1120' below ground surface (bgs) and that the fracture had increased resistance to re-fracturing after mineralization treatment. The second field demonstration was performed in a well with an identified channel in the cement near the wellbore at approx. 1020' bgs. The in situ mineralization treatment resulted in reduced pressure decay during shut in periods and reduced injectivity. In addition, a noticeable difference was observed in the solids percentage in the ultrasonic imaging logs before and after biomineralization treatment. The presentation will summarize and put into context the field and our recent laboratory research focusing on permeability manipulation using the in situ ureolysis-driven mineralization technology under ambient and subsurface pressure conditions. We have demonstrated permeability reductions of 3-6 orders of magnitude in 100 µm to 4mm gaps between shale, sandstone and cement/steel interfaces.

  15. Research in Fluid Mechanics, Control Theory and Such in Yugoslavia

    Science.gov (United States)

    1988-08-17

    microcom- verized coal in a steam reactor . There is presently a joint puter control systems, industrial robot systems, systems German and Yugoslav program on...of computer aided design to the semibatch column con- involves over 30 industrial companies and the two Slovene trol connected with the paper mill...M. Milanovic, "Computer Stefan Institute. Aided Design of Semibatch Distillation Column Control,’ Proceedings of the 2nd European Simulation Congress

  16. Shear-stress-controlled dynamics of nematic complex fluids.

    Science.gov (United States)

    Klapp, Sabine H L; Hess, Siegfried

    2010-05-01

    Based on a mesoscopic theory we investigate the nonequilibrium dynamics of a sheared nematic liquid, with the control parameter being the shear stress σ xy (rather than the usual shear rate, γ). To this end we supplement the equations of motion for the orientational order parameters by an equation for γ, which then becomes time dependent. Shearing the system from an isotropic state, the stress-controlled flow properties turn out to be essentially identical to those at fixed γ. Pronounced differences occur when the equilibrium state is nematic. Here, shearing at controlled γ yields several nonequilibrium transitions between different dynamic states, including chaotic regimes. The corresponding stress-controlled system has only one transition from a regular periodic into a stationary (shear-aligned) state. The position of this transition in the σ xy-γ plane turns out to be tunable by the delay time entering our control scheme for σ xy. Moreover, a sudden change in the control method can stabilize the chaotic states appearing at fixed γ.

  17. A randomized controlled trial of isotonic versus hypotonic maintenance intravenous fluids in hospitalized children

    Directory of Open Access Journals (Sweden)

    Laforte Diane

    2011-09-01

    Full Text Available Abstract Background Isotonic saline has been proposed as a safer alternative to traditional hypotonic solutions for intravenous (IV maintenance fluids to prevent hyponatremia. However, the optimal tonicity of maintenance intravenous fluids in hospitalized children has not been determined. The objective of this study was to estimate and compare the rates of change in serum sodium ([Na] for patients administered either hypotonic or isotonic IV fluids for maintenance needs. Methods This was a masked controlled trial. Randomization was stratified by admission type: medical patients and post-operative surgical patients, aged 3 months to 18 years, who required IV fluids for at least 8 hours. Patients were randomized to receive either 0.45% or 0.9% saline in 5.0% dextrose. Treating physicians used the study fluid for maintenance; infusion rate and the use of additional fluids were left to their discretion. Results Sixteen children were randomized to 0.9% saline and 21 to 0.45% saline. Baseline characteristics, duration (average of 12 hours and rate of study fluid infusion, and the volume of additional isotonic fluids given were similar for the two groups. [Na] increased significantly in the 0.9% group (+0.20 mmol/L/h [IQR +0.03, +0.4]; P = 0.02 and increased, but not significantly, in the 0.45% group (+0.08 mmol/L/h [IQR -0.15, +0.16]; P = 0.07. The rate of change and absolute change in serum [Na] did not differ significantly between groups. Conclusions When administered at the appropriate maintenance rate and accompanied by adequate volume expansion with isotonic fluids, 0.45% saline did not result in a drop in serum sodium during the first 12 hours of fluid therapy in children without severe baseline hyponatremia. Confirmation in a larger study is strongly recommended. Clinical Trial Registration Number NCT00457873 (http://www.clinicaltrials.gov/

  18. Transputers in Fluid Power - Design and Applications. Chapter 5 in Advances in Hydraulic Control Systems

    DEFF Research Database (Denmark)

    Conrad, Finn

    Deals with results and trends on mechatronics in fluid power and intelligent control of machines and robots. New results are presented concerning transputer-basen distributed control of machines and robots. Experimental results with the DTU mechatronic test facility are presented and discussed. S....... Several adaptive control algoritms are investigated and evaluated. Promissing results are obtained with Computed Valve-Input Control (CIC), Adaptive Model-based Actuator Control (AMAC) and Linear Pertubation Adaptive Control (LPAC).......Deals with results and trends on mechatronics in fluid power and intelligent control of machines and robots. New results are presented concerning transputer-basen distributed control of machines and robots. Experimental results with the DTU mechatronic test facility are presented and discussed...

  19. Active control of vibrations and noise by electrorheological fluids and piezoelectric materials

    Science.gov (United States)

    Amorosi, Joseph J.

    The combination of electrorheological (ER) fluids and piezoelectric actuators into one actively controlled intelligent sandwich plate structure for either noise or vibration control is investigated in this study. The simply supported sandwich plate consists of a core of four cavities filled with ER fluid, two elastic outer face plates, bottom plate cross stiffeners and symmetrically bonded surface piezoceramic (PZT) actuator patches. Analytical and computational simulations are performed to obtain the resultant structural response to random inputs, noise transmission into a rectangular enclosure, and sound radiation into a semi-infinite acoustic half space. An equivalent, homogeneous plate model is used in the modal decomposition of the derived governing equations of motion. This equivalency is obtained by taking the modal frequencies and mode shapes, calculated by the finite element method, to be that of the sandwich plate. The effect of actively controlling the ER fluid's stiffness material properties is incorporated into the modal frequencies and mode shapes by altering the sandwich plate's core shear and elastic moduli whereas ER fluid controllable damping is directly incorporated into the governing equations of motion as equivalent modal damping. The effect of the PZT actuators is incorporated into the governing equations of motion through direct velocity feedback utilizing collocated control. A two part control strategy is developed. First, the appropriate ER fluid voltage potential and then the PZT actuator gains are selected. Numerical results obtained in this study indicate that using ER and PZT active control up to 50 dB of noise reduction is possible at certain frequency ranges. In addition, about 15 dB reduction of the overall radiated sound pressure level can be obtained. However, for the available ER and PZT materials, the reduction of overall sound pressure to random input is shown to be on the order of 5 to 8 decibels. To improve on noise

  20. Active noise control - Piezoceramic actuators in fluid/structure interaction models

    Science.gov (United States)

    Banks, H. T.; Fang, W.; Smith, R. C.

    1991-01-01

    A model for a 2-D acoustic cavity with a flexible boundary (a beam) controlled via piezoceramic patches producing bending moments in the beam is considered. The associated control problem for this fluid/structure interaction system to reduce the acoustic pressure in the cavity involves unbounded control inputs. Approximation methods in the context of an LQR state space formulation are discussed, and numerical results are presented to demonstrate the effectiveness of this approach in computing feedback controls for noise reduction.

  1. Active Lubrication for Reducing Wear and Vibration: A combination of Fluid Power Control and Tribology

    DEFF Research Database (Denmark)

    Nicoletti, Rodrigo; Santos, Ilmar

    2002-01-01

    The use of fluid power to reduce and control rotor vibration in rotating machines is investigated. An active hybrid bearing is studied, whose main objective is to reduce wear and vibration between rotating and stationary machinery parts. By injecting pressurised oil into the oil film, through...... with experiment, and simulations show the feasibility of controlling shaft vibration through this active device....

  2. Control of fluid-containing rotating rigid bodies

    CERN Document Server

    Gurchenkov, Anatoly A

    2013-01-01

    This book is devoted to the study of the dynamics of rotating bodies with cavities containing liquid. Two basic classes of motions are analyzed: rotation and libration. Cases of complete and partial filling of cavities with ideal liquid and complete filling with viscous liquid are treated. The volume presents a method for obtaining relations between angular velocities perpendicular to main rotation and external force momentums, which are treated as control. The developed models and methods of solving dynamical problems as well as numerical methods for solving problems of optimal control can be

  3. Motion Control of Disc Electrode by Electrorheological Fluids

    Science.gov (United States)

    Tsuda, Kazutoshi; Hirose, Yuji; Ogura, Hironao; Otsubo, Yasufumi

    2008-07-01

    The electrorheological(ER) suspensions are sandwiched between two flat disc electrodes with the radial line patterns. The pattern electrodes are fixed on the parallel plate geometry on a stress-controlled rheometer which was modified for the ER experiments. The motion of disk electrodes analyzed as a function of electrification modes to obtain the basic data for ER actuators.

  4. Application of Oral Fluid Assays in Support of Mumps, Rubella and Varicella Control Programs

    Directory of Open Access Journals (Sweden)

    Peter A. C. Maple

    2015-12-01

    Full Text Available Detection of specific viral antibody or nucleic acid produced by infection or immunization, using oral fluid samples, offers increased potential for wider population uptake compared to blood sampling. This methodology is well established for the control of HIV and measles infections, but can also be applied to the control of other vaccine preventable infections, and this review describes the application of oral fluid assays in support of mumps, rubella and varicella national immunization programs. In England and Wales individuals with suspected mumps or rubella, based on clinical presentation, can have an oral fluid swab sample taken for case confirmation. Universal varicella immunization of children has led to a drastic reduction of chickenpox in those countries where it is used; however, in England and Wales such a policy has not been instigated. Consequently, in England and Wales most children have had chickenpox by age 10 years; however, small, but significant, numbers of adults remain susceptible. Targeted varicella zoster virus (VZV immunization of susceptible adolescents offers the potential to reduce the pool of susceptible adults and oral fluid determination of VZV immunity in adolescents is a potential means of identifying susceptible individuals in need of VZV vaccination. The main application of oral fluid testing is in those circumstances where blood sampling is deemed not necessary, or is undesirable, and when the documented sensitivity and specificity of the oral fluid assay methodology to be used is considered sufficient for the purpose intended.

  5. Cerebrospinal fluid proteomics and protein biomarkers in frontotemporal lobar degeneration: Current status and future perspectives.

    Science.gov (United States)

    Oeckl, Patrick; Steinacker, Petra; Feneberg, Emily; Otto, Markus

    2015-07-01

    Frontotemporal lobar degeneration (FTLD) comprises a spectrum of rare neurodegenerative diseases with an estimated prevalence of 15-22 cases per 100,000 persons including the behavioral variant of frontotemporal dementia (bvFTD), progressive non-fluent aphasia (PNFA), semantic dementia (SD), FTD with motor neuron disease (FTD-MND), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). The pathogenesis of the diseases is still unclear and clinical diagnosis of FTLD is hampered by overlapping symptoms within the FTLD subtypes and with other neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). Intracellular protein aggregates in the brain are a major hallmark of FTLD and implicate alterations in protein metabolism or function in the disease's pathogenesis. Cerebrospinal fluid (CSF) which surrounds the brain can be used to study changes in neurodegenerative diseases and to identify disease-related mechanisms or neurochemical biomarkers for diagnosis. In the present review, we will give an overview of the current literature on proteomic studies in CSF of FTLD patients. Reports of targeted and unbiased proteomic approaches are included and the results are discussed in regard of their informative value about disease pathology and the suitability to be used as diagnostic biomarkers. Finally, we will give some future perspectives on CSF proteomics and a list of candidate biomarkers which might be interesting for validation in further studies. This article is part of a Special Issue entitled: Neuroproteomics: Applications in neuroscience and neurology.

  6. Phononic Crystal Plate with Hollow Pillars Actively Controlled by Fluid Filling

    Directory of Open Access Journals (Sweden)

    Yabin Jin

    2016-05-01

    Full Text Available We investigate theoretically the properties of phononic crystal plates with hollow pillars. Such crystals can exhibit confined whispering gallery modes around the hollow parts of the pillars whose localization can be increased by separating the pillar from the plate by a full cylinder. We discuss the behaviors of these modes and their potential applications in guiding and filtering. Filling the hollow parts with a fluid gives rise to new localized modes, which depend on the physical properties and height of the fluid. Thus, these modes can be actively controlled for the purpose of multichannel multiplexing. In particular, one can obtain localized modes associated with the compressional vibrations of the fluid along its height. They can be used for the purpose of sensing the acoustic properties of the fluid or their variations with temperature.

  7. Status of the National Ignition Facility Integrated Computer Control System

    Energy Technology Data Exchange (ETDEWEB)

    Lagin, L; Bryant, R; Carey, R; Casavant, D; Edwards, O; Ferguson, W; Krammen, J; Larson, D; Lee, A; Ludwigsen, P; Miller, M; Moses, E; Nyholm, R; Reed, R; Shelton, R; Van Arsdall, P J; Wuest, C

    2003-10-13

    . NIF's target experimental systems are also being installed in preparation for experiments to begin in late 2003. This talk will provide a detailed look at the status of the control system.

  8. Dissertation Defense: Computational Fluid Dynamics Uncertainty Analysis for Payload Fairing Spacecraft Environmental Control Systems

    Science.gov (United States)

    Groves, Curtis Edward

    2014-01-01

    Spacecraft thermal protection systems are at risk of being damaged due to airflow produced from Environmental Control Systems. There are inherent uncertainties and errors associated with using Computational Fluid Dynamics to predict the airflow field around a spacecraft from the Environmental Control System. This paper describes an approach to quantify the uncertainty in using Computational Fluid Dynamics to predict airflow speeds around an encapsulated spacecraft without the use of test data. Quantifying the uncertainty in analytical predictions is imperative to the success of any simulation-based product. The method could provide an alternative to traditional validation by test only mentality. This method could be extended to other disciplines and has potential to provide uncertainty for any numerical simulation, thus lowering the cost of performing these verifications while increasing the confidence in those predictions.Spacecraft requirements can include a maximum airflow speed to protect delicate instruments during ground processing. Computational Fluid Dynamics can be used to verify these requirements; however, the model must be validated by test data. This research includes the following three objectives and methods. Objective one is develop, model, and perform a Computational Fluid Dynamics analysis of three (3) generic, non-proprietary, environmental control systems and spacecraft configurations. Several commercially available and open source solvers have the capability to model the turbulent, highly three-dimensional, incompressible flow regime. The proposed method uses FLUENT, STARCCM+, and OPENFOAM. Objective two is to perform an uncertainty analysis of the Computational Fluid Dynamics model using the methodology found in Comprehensive Approach to Verification and Validation of Computational Fluid Dynamics Simulations. This method requires three separate grids and solutions, which quantify the error bars around Computational Fluid Dynamics predictions

  9. Dissertation Defense Computational Fluid Dynamics Uncertainty Analysis for Payload Fairing Spacecraft Environmental Control Systems

    Science.gov (United States)

    Groves, Curtis Edward

    2014-01-01

    Spacecraft thermal protection systems are at risk of being damaged due to airflow produced from Environmental Control Systems. There are inherent uncertainties and errors associated with using Computational Fluid Dynamics to predict the airflow field around a spacecraft from the Environmental Control System. This paper describes an approach to quantify the uncertainty in using Computational Fluid Dynamics to predict airflow speeds around an encapsulated spacecraft without the use of test data. Quantifying the uncertainty in analytical predictions is imperative to the success of any simulation-based product. The method could provide an alternative to traditional "validation by test only" mentality. This method could be extended to other disciplines and has potential to provide uncertainty for any numerical simulation, thus lowering the cost of performing these verifications while increasing the confidence in those predictions. Spacecraft requirements can include a maximum airflow speed to protect delicate instruments during ground processing. Computational Fluid Dynamics can be used to verify these requirements; however, the model must be validated by test data. This research includes the following three objectives and methods. Objective one is develop, model, and perform a Computational Fluid Dynamics analysis of three (3) generic, non-proprietary, environmental control systems and spacecraft configurations. Several commercially available and open source solvers have the capability to model the turbulent, highly three-dimensional, incompressible flow regime. The proposed method uses FLUENT, STARCCM+, and OPENFOAM. Objective two is to perform an uncertainty analysis of the Computational Fluid Dynamics model using the methodology found in "Comprehensive Approach to Verification and Validation of Computational Fluid Dynamics Simulations". This method requires three separate grids and solutions, which quantify the error bars around Computational Fluid Dynamics

  10. Controlling Particle Morphologies at Fluid Interfaces: Macro- and Micro- approaches

    Science.gov (United States)

    Beesabathuni, Shilpa Naidu

    The controlled generation of varying shaped particles is important for many applications: consumer goods, biomedical diagnostics, food processing, adsorbents and pharmaceuticals which can benefit from the availability of geometrically complex and chemically inhomogeneous particles. This thesis presents two approaches to spherical and non-spherical particle synthesis using macro and microfluidics. In the first approach, a droplet microfluidic technique is explored to fabricate spherical conducting polymer, polyaniline, particles with precise control over morphology and functionality. Microfluidics has recently emerged as an important alternate to the synthesis of complex particles. The conducting polymer, polyaniline, is widely used and known for its stability, high conductivity, and favorable redox properties. In this approach, monodisperse micron-sized polyaniline spherical particles were synthesized using two-phase droplet microfluidics from Aniline and Ammonium persulfate oxidative polymerization in an oil-based continuous phase. The morphology of the polymerized particles is porous in nature which can be used for encapsulation as well as controlled release applications. Encapsulation of an enzyme, glucose oxidase, was also performed using the technique to synthesize microspheres for glucose sensing. The polymer microspheres were characterized using SEM, UV-Vis and EDX to understand the relationship between their microstructure and stability. In the second approach, molten drop impact in a cooling aqueous medium to generate non-spherical particles was explored. Viscoelastic wax based materials are widely used in many applications and their performance and application depends on the particle morphology and size. The deformation of millimeter size molten wax drops as they impacted an immiscible liquid interface was investigated. Spherical molten wax drops impinged on a cooling water bath, then deformed and as a result of solidification were arrested into various

  11. [Status of the ventricular system and dynamics of the cerebrospinal fluid changes in chronic brain diseases].

    Science.gov (United States)

    Burtsev, E M; Starodubtsev, A V

    1988-01-01

    Using noninvasive (echoventriculometry (Echo-VM), REG and invasive (planimetric PEG, graphic recording of the CSF pressure) methods of examination, the authors determined the size of cerebral ventricles and the status of the cerebral hemo- and CSF dynamics in 606 patients with various chronic diseases of the brain (consequences of craniocerebral injury, epilepsy, discirculatory encephalopathy, etc.). According to PEG and Echo-VM findings, two groups of patients were distinguished. In moderate dilatation of cerebral ventricles the most significant finding was an increase in the pulse pressure of the CSF, whereas its mean pressure was normal or slightly elevated. In patients with pronounced hydrocephaly the pulse and mean pressure of the CSF tended to decrease. The progress of hydrocephaly was parallelled by increasing disorders of the cerebral hemodynamics expressed in hindered venous outflow from the cranial cavity and elevated peripheral vascular resistance. Four CSF-related syndromes have been identified (normotension, total CSF hypertension, intraventricular tension, total CSF hypotension) differing in their diagnostic and prognostic significance and in the pathogenesis of disorders of the hemo- and CSF dynamics.

  12. Analysis of a micro-scale pump which uses controlled acoustic streaming for fluid locomotion

    Energy Technology Data Exchange (ETDEWEB)

    Dohner, J.L.

    1998-01-01

    In this report the analysis of a micro-scale pump is described. This micro-pump uses active control to produce a distributed body force in a fluid micro-channel. The desired effect of this body force is to drive fluid through the channel. Limitations, assumptions, and design parameters are discussed. The mathematical analysis of pump dynamics is explained in detail. A perturbation analysis is used on the equations of mass, momentum and state to produce equations of motion for first and second order effects. The first order effects are described by linear wave motion in the fluid and are found by using integral equation methods. The second order effects are driven by body forces resulting from first order effects. Thus, by controlling the production of wave motion in the channel, second order excitation can also be controlled. This report is all theory and therefore needs experimental validation. Although many of the assumptions used in this report have been used elsewhere in the literature and have been found to be sufficient, there are many aspects of the problem which have been left unresolved. In particular, flow separation in the fluid channel is a critical problem. If the fluid does not separate, pumping will occur through the channel, however, if internal or external forces are not sufficient to stop separation, this type of pump will not function.

  13. Mechanisms controlling the volume of pleural fluid and extravascular lung water

    Directory of Open Access Journals (Sweden)

    G. Miserocchi

    2009-12-01

    Full Text Available Pleural and interstitial lung fluid volumes are strictly controlled and maintained at the minimum thanks to the ability of lymphatics to match the increase in filtration rate. In the pleural cavity, fluid accumulation is easily accommodated by retraction of lung and chest wall (high compliance of the pleural space; the increase of lymph flow per unit increase in pleural fluid volume is high due to the great extension of the parietal lymphatic. However, for the lung interstitium, the increase in lymph flow to match increased filtration does not need to be so great. In fact, increased filtration only causes a minor increase in extravascular water volume (<10% due to a marked increase in interstitial pulmonary pressure (low compliance of the extracellular matrix which, in turn, buffers further filtration. Accordingly, a less extended lymphatic network is needed. The efficiency of lymphatic control is achieved through a high lymphatic conductance in the pleural fluid and through a low interstitial compliance for the lung interstitium. Fluid volume in both compartments is so strictly controlled that it is difficult to detect initial deviations from the physiological state; thus, a great physiological advantage turns to be a disadvantage on a clinical basis as it prevents an early diagnosis of developing disease.

  14. Numerical simulation of flow separation control by oscillatory fluid injection

    Science.gov (United States)

    Resendiz Rosas, Celerino

    2005-07-01

    In this work, numerical simulations of flow separation control are performed. The separation control technique studied is called "synthetic jet actuation". The developed code employs a cell centered finite volume scheme which handles viscous, steady and unsteady compressible turbulent flows. The pulsating zero mass jet flow is simulated by imposing a harmonically varying transpiration boundary condition on the airfoil's surface. Turbulence is modeled with the algebraic model of Baldwin and Lomax. The application of synthetic jet actuators is based in their ability to energize the boundary layer, thereby providing significant increase in the lift coefficient. This has been corroborated experimentally and it is corroborated numerically in this research. The performed numerical simulation investigates the flow over a NACA0015 airfoil. For this flow Re = 9 x 105 and the reduced frequency and momentum coefficient are F + = 1.1 and Cmu = 0.04 respectively. The oscillatory injection takes place at 12.27% chord from the leading edge. A maximum increase in the mean lift coefficient of 93% is predicted by the code. A discrepancy of approximately 10% is observed with corresponding experimental data from the literature. The general trend is, however, well captured. The discrepancy is attributed to the modeling of the injection boundary condition and to the turbulence model. A sensitivity analysis of the lift coefficient to different values of the oscillation parameters is performed. It is concluded that tangential injection, F+ ≈ O(1) and the utilized grid resolution around the site of injection are optimal. Streamline fields obtained for different angles of injection are analyzed. Flow separation and attachment as functions of the injection angle and of the velocity of injection can be observed. It is finally concluded that a reliable numerical tool has been developed which can be utilized as a support tool in the optimization of the synthetic jet operation and in the

  15. Analysis and control of the METC fluid bed gasifier. Quarterly report, April 1995--June 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    This document summarizes work performed for the period 4/1/95 to 7/31/95 on contract no. DE-FG21-94MC31384 (Work accomplished during the period 10/1/94 to 3/31/94 was summarized in the previous technical progress report included in the appendix of this report). In this work, three components will form the basis for design of a control scheme for the Fluidized Bed Gasifier (FBG) at METC: (1) a control systems analysis based on simple linear models derived from process data, (2) review of the literature on fluid bed gasifier operation and control, and (3) understanding of present FBG operation and real world considerations. Tasks accomplished during the present reporting period include: (1) Completion of a literature survey on Fluid Bed Gasifier control, (2) Observation of the FBG during the week of July 17 to July 21, and (3) Suggested improvements to the control of FBG backpressure and MGCR pressure.

  16. Hypertonic fluid administration in patients with septic shock: a prospective randomized controlled pilot study.

    Science.gov (United States)

    van Haren, Frank M P; Sleigh, James; Boerma, E Christiaan; La Pine, Mary; Bahr, Mohamed; Pickkers, Peter; van der Hoeven, Johannes G

    2012-03-01

    We assessed the short-term effects of hypertonic fluid versus isotonic fluid administration in patients with septic shock. This was a double-blind, prospective randomized controlled trial in a 15-bed intensive care unit. Twenty-four patients with septic shock were randomized to receive 250 mL 7.2% NaCl/6% hydroxyethyl starch (HT group) or 500 mL 6% hydroxyethyl starch (IT group). Hemodynamic measurements included mean arterial blood pressure (MAP), central venous pressure, stroke volume index, stroke volume variation, intrathoracic blood volume index, gastric tonometry, and sublingual microcirculatory flow as assessed by sidestream dark field imaging. Systolic tissue Doppler imaging velocities of the medial mitral annulus were measured using echocardiography to assess left ventricular contractility. Log transformation of the ratio MAP divided by the norepinephrine infusion rate (log MAP/NE) quantified the combined effect on both parameters. Compared with the IT group, hypertonic solution treatment resulted in an improvement in log MAP/NE (P = 0.008), as well as an increase in systolic tissue Doppler imaging velocities (P = 0.03) and stroke volume index (P = 0.017). No differences between the groups were found for preload parameters (central venous pressure, stroke volume variation, intrathoracic blood volume index) or for afterload parameters (systemic vascular resistance index, MAP). Hypertonic solution treatment decreased the need for ongoing fluid resuscitation (P = 0.046). No differences between groups were observed regarding tonometry or the sublingual microvascular variables. In patients with septic shock, hypertonic fluid administration did not promote gastrointestinal mucosal perfusion or sublingual microcirculatory blood flow in comparison to isotonic fluid. Independent of changes in preload or afterload, hypertonic fluid administration improved the cardiac contractility and vascular tone compared with isotonic fluid. The need for ongoing fluid

  17. Motion control of a rotor with a cavity with a viscous fluid

    NARCIS (Netherlands)

    Gurchenkov, A. A.; Esenkov, A. S.; Tsurkov, V. I.

    2007-01-01

    A formulation and solution procedure of optimal control problems for perturbed relative uniform motion of a body with a cavity filled with a viscous incompressible fluid are proposed. In this paper, the case with a cylinder is considered; however, this approach is basically true for the a cavity of

  18. Active Lubrication for Reducing Wear and Vibration: A combination of Fluid Power Control and Tribology

    DEFF Research Database (Denmark)

    Nicoletti, Rodrigo; Santos, Ilmar

    2002-01-01

    The use of fluid power to reduce and control rotor vibration in rotating machines is investigated. An active hybrid bearing is studied, whose main objective is to reduce wear and vibration between rotating and stationary machinery parts. By injecting pressurised oil into the oil film, through ori...

  19. Experiences of Using MATLAB/Simulink in Simulation and Control of Fluid Power Systems

    DEFF Research Database (Denmark)

    Zhou, Jianjun; Conrad, Finn; Sørensen, Torben

    1999-01-01

    MATLAB and Simulink are widely used as primary software tools in teaching and research around the word. This paper presents our experiences of using MATLAB/Simulink in simulation and control of fluid power systems. The application concerned mainly in this paper is a hydraulic test robot, shown...

  20. Experiences of Using MATLAB/Simulink in Simulation and Control of Fluid Power Systems

    DEFF Research Database (Denmark)

    Zhou, Jianjun; Conrad, Finn; Sørensen, Torben

    1999-01-01

    MATLAB and Simulink are widely used as primary software tools in teaching and research around the word. This paper presents our experiences of using MATLAB/Simulink in simulation and control of fluid power systems. The application concerned mainly in this paper is a hydraulic test robot, shown...

  1. Developments in Fluid Power Control of Machinery and Manipulators (2 of 2)

    DEFF Research Database (Denmark)

    Conrad, Finn; Sørensen, Torben; Zhou, Jianjun

    2000-01-01

    The paper reports and discusses results from a Danish mechatronic research programme focusing on intelligent actuators for motion control as well as results from the ESPRIT project SWING on IT-tools for rapid prototyping of fluid power components and systems....

  2. Computational Fluid Dynamics Uncertainty Analysis for Payload Fairing Spacecraft Environmental Control Systems

    Science.gov (United States)

    Groves, Curtis; Ilie, Marcel; Schallhorn, Paul

    2014-01-01

    Spacecraft components may be damaged due to airflow produced by Environmental Control Systems (ECS). There are uncertainties and errors associated with using Computational Fluid Dynamics (CFD) to predict the flow field around a spacecraft from the ECS System. This paper describes an approach to estimate the uncertainty in using CFD to predict the airflow speeds around an encapsulated spacecraft.

  3. Uncalibrated Visual Servo Control of Magnetically Actuated Microrobots in a Fluid Environment

    Directory of Open Access Journals (Sweden)

    Jenelle Armstrong Piepmeier

    2014-09-01

    Full Text Available Microrobots have a number of potential applications for micromanipulation and assembly, but also offer challenges in power and control. This paper describes an uncalibrated vision-based control system for magnetically actuated microrobots operating untethered at the interface between two immiscible fluids. The microrobots are 20 μm thick and approximately 100–200 μm in lateral dimension. Several different robot shapes are investigated. The robots and fluid are in a 20 × 20 × 15 mm vial placed at the center of four electromagnets. Pulse width modulation of the electromagnet currents is used to control robot speed and direction. Given a desired position, a controller based on recursive least square estimation drives the microrobot to the goal without a priori knowledge of system parameters such as drag coefficients or intrinsic and extrinsic camera parameters. Results are verified experimentally using a variety of microrobot shapes and system configurations.

  4. Osmotic/ionic status of body fluids in the euryhaline cephalopod suggest possible parallel evolution of osmoregulation.

    Science.gov (United States)

    Sakamoto, Tatsuya; Ogawa, Satoshi; Nishiyama, Yudai; Akada, Chiaki; Takahashi, Hideya; Watanabe, Taro; Minakata, Hiroyuki; Sakamoto, Hirotaka

    2015-09-25

    Acclimation from marine to dilute environments constitutes among the dramatic evolutionary transitions in the history of life. Such adaptations have evolved in multiple lineages, but studies of the blood/hemolymph homeostasis mechanisms are limited to those using evolutionarily advanced Deuterostome (chordates) and Ecdysozoa (crustaceans). Here, we examined hemolymph homeostasis in the advanced Lophotrochozoa/mollusc, the other unexplored taxa, and its possible regulation by the vasopressin/oxytocin superfamily peptides known to be implicated in fluid homeostasis in Chordata and Arthropoda. The hemolymph osmotic and ionic status in the euryhaline cephalopod (Octopus ocellatus) following transfer from 30-ppt normal seawater to 20 ppt salinity indicate hyperosmo- and hyperionoregulatory abilities for more than 1 week, as in crustaceans and teleost fish. While ventilation frequency decreased by 1 day, Na(+)/K(+)-ATPase activity, which has been generally implicated in ion transport, was induced in two of the eight posterior gills after 1 week. In addition, the octopuses were intravenously injected with 1 or 100 ng/g octopressin or cephalotocin, which are Octopus vasopressin/oxytocin orthologs. After 1 day, octopressin, but not cephalotocin, decreased the hemolymph osmolality and Ca concentrations, as well as urinary Na concentrations. These data provide evidence for possible parallel evolution in hyperionoregulatory mechanisms and coordination by conserved peptides.

  5. Damping control of a CFRP cantilevered beam with electrorheological fluids actuator

    Science.gov (United States)

    Fukuda, Takehito; Oshima, Nobuo

    1996-04-01

    Effects of waveform and frequency of electric fields applied to electro-rheological (ER) fluids are investigated on structural damping of a CFRP composite beam containing ER fluids. As the experimental results, the rectangular waveform is more effective for control of ER effects than the sinusoidal one. In vibration analysis, a simplified mass-spring-damper system is adopted to feature the first flexural mode of the cantilevered composite beam, where the damping factor is changed in time as a function of waveform which is applied to electric fields.

  6. Identification of α1-Antitrypsin as a Potential Candidate for Internal Control for Human Synovial Fluid in Western Blot.

    Science.gov (United States)

    Wang, Shaowei; Zhou, Jingming; Wei, Xiaochun; Li, Pengcui; Li, Kai; Wang, Dongming; Wei, Fangyuan; Zhang, Jianzhong; Wei, Lei

    Western blot of synovial fluid has been widely used for osteoarthritis (OA) research and diagnosis, but there is no ideal loading control for this purpose. Although β-actin is extensively used as loading control in western blot, it is not suitable for synovial fluid because it is not required in synovial fluid as a cytoskeletal protein. A good loading control for synovial fluid in OA studies should have unchanged content in synovial fluids from normal and OA groups, because synovial fluid protein content can vary with changes in synovial vascular permeability with OA onset. In this study, we explore the potential of using α1-antitripsin (A1AT) as loading control for OA synovial fluid in western blot. A1AT level is elevated in inflammatory conditions such as rheumatoid arthritis (RA). Unlike RA, OA is a non-inflammation disease, which does not induce A1AT. In this study, we identified A1AT as an abundant component of synovial fluid by Mass Spectrometry and confirmed that the level of A1AT is relative constant between human OA and normal synovial fluid by western blot and ELISA. Hence, we proposed that A1AT may be a good loading control for western blot in human OA synovial fluid studies provided that pathological conditions such as RA or A1AT deficiency associated liver or lung diseases are excluded.

  7. Advances of fluid status assessment in hemodialysis patients%评估血液透析患者容量状态方法的进展

    Institute of Scientific and Technical Information of China (English)

    何群鹏

    2013-01-01

    准确评估血液透析(HD)患者细胞外液量(ECV)及容量状态是临床很重要且尚未解决的问题.目前评估ECV的方法有示踪剂稀释法、相对血容量监测法、超声测量上腔静脉直径及生物标记物等,但上述方法均不能准确反应容量状态.然而,生物电阻抗频谱分析法可能是目前评估HD患者容量状态的最佳方法.%The assessment of extracellular fluid volume (ECV) and fluid status is both important and challenging problems in hemodialysis patients.A variety of methods are used to assess the ECV,including tracer dilution techniques,relative blood volume monitoring,measurement of inferior vena cava diameter by ultrasound and biochemical markers,which do not reflect the ECV and fluid status accurately because they are indirect methods.Currently,bioimpedance spectroscopy (BIS) appears to be the most practical method for assessing ECV volume and fluid status in dialysis patients.

  8. Vibration control of flexible structures via electrorheological-fluid-based dampers

    Science.gov (United States)

    Wang, Kon-Well; Kim, Y. S.; Lee, H. S.; Shea, D. B.

    1993-09-01

    The semi-active control approach has been recognized to be effective for vibration suppression of flexible structures. The electrorheological (ER) fluid-based device is a good candidate for such applications. In this research, a new control law is developed to maximize the damping effect of ER dampers for structural vibration suppression under actuator constraints and viscous-frictional-combined damping. Both numerical simulations and experimental work have been carried out to evaluate and validate the theoretical predictions.

  9. 3rd Symposium on Fluid-Structure-Sound Interactions and Control

    CERN Document Server

    Lucey, AD; Liu, Yang; Huang, Lixi

    2016-01-01

    These proceedings primarily focus on advances in the theory, experiments, and numerical simulations of turbulence in the contexts of flow-induced vibration and noise, as well as their control. Fluid-related structural vibration and noise problems are often encountered in many engineering fields, increasingly making them a cause for concern. The FSSIC conference, held on 5-9 July 2015 in Perth, featured prominent keynote speakers such as John Kim, Nigel Peake, Song Fu and Colin Hansen, as well as talks on a broad range of topics: turbulence, fluid-structure interaction, fluid-related noise and the control/management aspects of these research areas, many of which are clearly interdisciplinary in nature. It provided a forum for academics, scientists and engineers working in all branches of Fluid-Structure-Sound Interactions and Control (FSSIC) to exchange and share the latest developments, ideas and advances, bringing them together researchers from East and West to push forward the frontiers of FSSIC, ensuring t...

  10. Intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children: a randomized controlled trial.

    Science.gov (United States)

    Mehta, Vishal; Singhi, Pratibha; Singhi, Sunit

    2007-10-01

    An open-label, randomized controlled study was conducted at a tertiary care teaching hospital to compare efficacy and safety of intravenous sodium valproate versus diazepam infusion for control of refractory status epilepticus. Forty children with refractory status epilepticus were randomized to receive either intravenous sodium valproate or diazepam infusion. Refractory status epilepticus was controlled in 80% of the valproate and 85% of the diazepam patients. The median time to control refractory status epilepticus was less in the valproate group (5 minutes) than the diazepam group (17 minutes; P diazepam group 60% required ventilation and 50% developed hypotension after starting diazepam infusion. No adverse effects on liver functions were seen with valproate. It is concluded that intravenous sodium valproate is an effective alternative to diazepam infusion in controlling refractory status epilepticus in children and is free of respiratory depression and hypotension.

  11. assessment of socioeconomic status and control of asthma in adults

    African Journals Online (AJOL)

    management, although asthma cannot be cured, but it ... Department of Family Medicine, University College Hospital, Ibadan, Nigeria. 3. Department of Medicine ... are the most widely used indicators of socioeconomic status (SES). Studies ...

  12. Longitudinal relationships between fluid status, inflammation, urine volume and plasma metabolites of icodextrin in patients randomized to glucose or icodextrin for the long exchange.

    Science.gov (United States)

    Davies, Simon J; Garcia Lopez, Elvia; Woodrow, Graham; Donovan, Kieron; Plum, Jorg; Williams, Paul; Johansson, Ann Catherine; Bosselmann, Hans-Peter; Heimburger, Olof; Simonsen, Ole; Davenport, Andrew; Lindholm, Bengt; Tranaeus, Anders; Divino Filho, Jose C

    2008-09-01

    Randomized trials have shown that icodextrin reduces the volume of extra-cellular fluid (ECFv) with variable effects on residual renal function. To explore this fluid shift and its possible mechanisms in more detail, prospectively collected data from one such trial, including measures of inflammation (C-reactive protein, tumour necrosis factor-alpha, albumin and low and high molecular weight hyaluronan) ANP (atrial naturetic peptide), an indirect marker of intra-vascular volume, plasma concentrations of icodextrin metabolites and alpha-amylase activity were analysed. 50 patients were randomized to either 2.27% glucose or icodextrin (n = 28) for a long exchange following a month run in. Blood samples were obtained at -1, 0, 3 and 6 months, coincident with measurements of urine volume and fluid status. In both randomized groups, a significant correlation between the fall in ECFv and the decline in urine volume was observed (P = 0.001), although the relative drop in urine volume for patients randomized to icodextrin tended to be less. At baseline, ANP was higher in patients with proportionately more ECFv for a given body water or height. Icodextrin patients had non-significantly higher ANP levels at baseline, whereas by 3 (P = 0.026) and 6 months (P = 0.016) these differed between groups due to divergence. There was a correlation between increasing ANP and reduced ECF at 3 months, r = -0.46, P = 0.007, in patients randomized to icodextrin, but not glucose. There were no relationships between fluid status and any inflammatory markers at any point of the study, with the exception of albumin at baseline, r = -0.39, P = 0.007. Amylase activities at -1 month and baseline were highly correlated, r = 0.89, P volume, fluid or inflammatory status. This analysis supports observational data that changes in fluid status are associated with changes in urine volume. Icodextrin was not associated with a greater fall in urine output despite its larger effect on ECFv. Changes in fluid

  13. Cryptic choice of conspecific sperm controlled by the impact of ovarian fluid on sperm swimming behavior.

    Science.gov (United States)

    Yeates, Sarah E; Diamond, Sian E; Einum, Sigurd; Emerson, Brent C; Holt, William V; Gage, Matthew J G

    2013-12-01

    Despite evidence that variation in male-female reproductive compatibility exists in many fertilization systems, identifying mechanisms of cryptic female choice at the gamete level has been a challenge. Here, under risks of genetic incompatibility through hybridization, we show how salmon and trout eggs promote fertilization by conspecific sperm. Using in vitro fertilization experiments that replicate the gametic microenvironment, we find complete interfertility between both species. However, if either species' ova were presented with equivalent numbers of both sperm types, conspecific sperm gained fertilization precedence. Surprisingly, the species' identity of the eggs did not explain this cryptic female choice, which instead was primarily controlled by conspecific ovarian fluid, a semiviscous, protein-rich solution that bathes the eggs and is released at spawning. Video analyses revealed that ovarian fluid doubled sperm motile life span and straightened swimming trajectory, behaviors allowing chemoattraction up a concentration gradient. To confirm chemoattraction, cell migration tests through membranes containing pores that approximated to the egg micropyle showed that conspecific ovarian fluid attracted many more spermatozoa through the membrane, compared with heterospecific fluid or water. These combined findings together identify how cryptic female choice can evolve at the gamete level and promote reproductive isolation, mediated by a specific chemoattractive influence of ovarian fluid on sperm swimming behavior.

  14. Thirteenth symposium on energy engineering sciences: Proceedings. Fluid/thermal processes, systems analysis and control

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-11-01

    The DOE Office of Basic Energy Sciences, of which Engineering Research is a component program, is responsible for the long-term mission-oriented research in the Department. Consistent with the DOE/BES mission, the Engineering Research Program is charged with the identification, initiation, and management of fundamental research on broad, generic topics addressing energy-related engineering problems. Its stated goals are: (1) to improve and extend the body of knowledge underlying current engineering practice so as to create new options for enhancing energy savings and production, for prolonging useful life of energy-related structures and equipment, and for developing advanced manufacturing technologies and materials processing with emphasis on reducing costs with improved industrial production and performance quality; and (2) to expand the store of fundamental concepts for solving anticipated and unforeseen engineering problems in the energy technologies. The meeting covered the following areas: (1) fluid mechanics 1--fundamental properties; (2) fluid mechanics 2--two phase flow; (3) thermal processes; (4) fluid mechanics 3; (5) process analysis and control; (6) fluid mechanics 4--turbulence; (7) fluid mechanics 5--chaos; (8) materials issues; and (9) plasma processes. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  15. Modeling and Control of Magnetic Fluid Deformable Mirrors for Adaptive Optics Systems

    CERN Document Server

    Wu, Zhizheng; Ben Amara, Foued

    2013-01-01

    Modeling and Control of Magnetic Fluid Deformable Mirrors for Adaptive Optics Systems presents a novel design of wavefront correctors based on magnetic fluid deformable mirrors (MFDM) as well as corresponding control algorithms. The presented wavefront correctors are characterized by their linear, dynamic response. Various mirror surface shape control algorithms are presented along with experimental evaluations of the performance of the resulting adaptive optics systems. Adaptive optics (AO) systems are used in various fields of application to enhance the performance of optical systems, such as imaging, laser, free space optical communication systems, etc. This book is intended for undergraduate and graduate students, professors, engineers, scientists and researchers working on the design of adaptive optics systems and their various emerging fields of application. Zhizheng Wu is an associate professor at Shanghai University, China. Azhar Iqbal is a research associate at the University of Toronto, Canada. Foue...

  16. A hybrid attitude controller consisting of electromagnetic torque rods and an active fluid ring

    Science.gov (United States)

    Nobari, Nona A.; Misra, Arun K.

    2014-01-01

    In this paper, a novel hybrid actuation system for satellite attitude stabilization is proposed along with its feasibility analysis. The system considered consists of two magnetic torque rods and one fluid ring to produce the control torque required in the direction in which magnetic torque rods cannot produce torque. A mathematical model of the system dynamics is derived first. Then a controller is developed to stabilize the attitude angles of a satellite equipped with the abovementioned set of actuators. The effect of failure of the fluid ring or a magnetic torque rod is examined as well. It is noted that the case of failure of the magnetic torque rod whose torque is along the pitch axis is the most critical, since the coupling between the roll or yaw motion and the pitch motion is quite weak. The simulation results show that the control system proposed is quite fault tolerant.

  17. Current Status and Control Measures of Ecological Restoration in Karst Rocky Desertification Area of Guizhou

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    [Objective] The aim was to analyze the current status and control measures of ecological restoration in Karst rocky desertification area of Guizhou.[Method] The current status and existing problems of ecological restoration in Karst rocky desertification area of Guizhou were studied firstly,and main control measures were put forward according to existing problems.[Result] At present,Karst rocky desertification area in Guizhou has suitable ecological environment,obvious control results and rich control exper...

  18. Psychiatric illness, socioeconomic status, and marital status in people committing suicide: a matched case-sibling-control study

    DEFF Research Database (Denmark)

    Agerbo, Esben; Qin, Ping; Mortensen, Preben Bo

    2006-01-01

    STUDY OBJECTIVE: Suicides cluster in both families and persons with psychiatric disorders and socioeconomic disadvantages. This study compares these factors between suicide cases, their siblings, and population based controls in an attempt to evaluate both the familial and the individual element...... and controls in exposure to hospitalised psychiatric disorders and socioeconomic disadvantages, although these factors contribute to the familial aggregation of suicides....... of these factors. DESIGN: Nested case-control study. Information on causes of death, psychiatric admission, marital status, children, and socioeconomic factors was obtained from routine registers. SETTING: Denmark. PARTICIPANTS: 985 suicide cases, 1104 sex-age (+/-3 years) matched siblings, and 16 619 controls...

  19. Prospective Randomized Controlled Trial of Liberal Vs Restricted Perioperative Fluid Management in Patients Undergoing Pancreatectomy.

    Science.gov (United States)

    Grant, Florence; Brennan, Murray F; Allen, Peter J; DeMatteo, Ronald P; Kingham, T Peter; D'Angelica, Michael; Fischer, Mary E; Gonen, Mithat; Zhang, Hao; Jarnagin, William R

    2016-10-01

    The aim of this study is to examine, by a prospective randomized controlled trial, the influence of liberal (LIB) vs restricted (RES) perioperative fluid administration on morbidity following pancreatectomy. Randomized controlled trials in patients undergoing major intra-abdominal surgery have challenged the historical use of LIB fluid administration, suggesting that a more restricted regimen may be associated with fewer postoperative complications. Patients scheduled to undergo pancreatic resection were consented for randomization to a LIB (n = 164) or RES (n = 166) perioperative fluid regimen. Sample size was designed with 80% power to decrease Grade 3 complications from 35% to 21%. Between July 2009 and July 2015, we randomized 330 patients undergoing pancreaticoduodenectomy (PD, n = 218), central (n = 16), or distal pancreatectomy (DP, n = 96). Patients were equally distributed for all demographic and intraoperative characteristics. Intraoperatively, LIB patients received crystalloid 12 mL/kg/h and RES patients 6 mL/kg/h. Cumulative crystalloid given (median, range, mL) days 0 to 3 was LIB: 12,252 (6600 to 21,365), RES 7808 (2700 to 16,274) P LIB and 27% of RES patients (P = 0.6). Median length of stay was 7 and 5 days for PD and DP, respectively, in both arms. In a high volume institution, major perioperative complications from pancreatic resection were not significantly influenced by fluid regimens that differed approximately 1.6-fold.

  20. Rationale and design of BISTRO: a randomized controlled trial to determine whether bioimpedance spectroscopy-guided fluid management maintains residual kidney function in incident haemodialysis patients.

    Science.gov (United States)

    Davies, Simon J; Caskey, Fergus J; Coyle, David; Lindley, Elizabeth; Macdonald, Jamie; Mitra, Sandip; Wilkie, Martin; Davenport, Andrew; Farrington, Ken; Dasgupta, Indranil; Ormandy, Paula; Andronis, Lazaros; Solis-Trapala, Ivonne; Sim, Julius

    2017-04-26

    Preserved residual kidney function (RKF) and normal fluid status are associated with better patient outcomes in incident haemodialysis patients. The objective of this trial is to determine whether using bioimpedance technology in prescribing the optimal post-dialysis weight can reduce the rate of decline of RKF and potentially improve patient outcomes. 516 pateints commencing haemodialysis, aged >18 with RKF of > 3 ml/min/1.73 m(2) or a urine volume >500 ml per day or per the shorter inter-dialytic period will be consented and enrolled into a pragmatic, open-label, randomized controlled trial. The intervention is incorporation of bioimpedance spectroscopy (BI) determination of normally hydrated weight to set a post-dialysis target weight that limits volume depletion, compared to current standard practice. Clinicians and participants will be blinded to BI measures in the control group and a standardized record capturing management of fluid status will be used in all participants. Primary outcome is preservation of residual kidney function assessed as time to anuria (≤100 ml/day or ≤200 ml urine volume in the short inter-dialytic period). A sample size of 516 was based upon a cumulative incidence of 30% anuria in the control group and 20% in the treatment group and 11% competing risks (death, transplantation) over 10 months, with up to 2 years follow-up. Secondary outcomes include rate of decline in small solute clearance, significant adverse events, hospitalization, loss of vascular access, cardiovascular events and interventions, dialysis efficacy and safety, dialysis-related symptoms and quality of life. Economic evaluation will be carried out to determine the cost-effectiveness of the intervention. Analyses will be adjusted for patient characteristics and dialysis unit practice patterns relevant to fluid management. This trial will establish the added value of undertaking BI measures to support clinical management of fluid status and establish the

  1. Remarks on Hierarchic Control for a Linearized Micropolar Fluids System in Moving Domains

    Energy Technology Data Exchange (ETDEWEB)

    Jesus, Isaías Pereira de, E-mail: isaias@ufpi.edu.br [Universidade Federal do Piauí, Dpto. Matemática (Brazil)

    2015-12-15

    We study a Stackelberg strategy subject to the evolutionary linearized micropolar fluids equations in domains with moving boundaries, considering a Nash multi-objective equilibrium (non necessarily cooperative) for the “follower players” (as is called in the economy field) and an optimal problem for the leader player with approximate controllability objective. We will obtain the following main results: the existence and uniqueness of Nash equilibrium and its characterization, the approximate controllability of the linearized micropolar system with respect to the leader control and the existence and uniqueness of the Stackelberg–Nash problem, where the optimality system for the leader is given.

  2. Vibration control of an artificial muscle manipulator with a magnetorheological fluid brake

    Science.gov (United States)

    Tomori, H.; Midorikawa, Y.; Nakamura, T.

    2013-02-01

    Recently, proposed applications of robots require them to contact human safely. Therefore, we focus on pneumatic rubber artificial muscle. This actuator is flexible, light, and has high-power density. However, because the artificial muscle is flexible, it vibrates when there is a high load. Therefore, we paid attention to the magnetorheological (MR) fluid. We propose a control method of the MR brake considering energy of the manipulator system. By this control method, MR brake dissipates energy leading to vibration of the manipulator. In this paper, we calculated the energy and controlled the MR brake. And, we deliberated the proposal method by simulation using the dynamic model of the manipulator, and experiment.

  3. Development Status of the Rad-Tolerant TTEthernet Controller

    Science.gov (United States)

    Fidi, Christian; van Masar, Ivan

    2016-08-01

    The use of switched networking technologies for aerospace and more recently automotive brings additional advantages for space applications like the increase in performance of the overall avionics of a spacecraft. These networks are characterized by a central device (switch) and a point-to-point structure between switch and terminal devices that eases electrical and logical insulation.However, for a use in highly-reliable or highly-available applications as in launchers or satellites systems, these network technologies need to provide built-in determinism and redundancy to fulfill the tight latency and jitter requirements of the avionics control loops and the respective hardware redundancy. Therefore a state of the art networking technology already provides these features and allows the modularity and scalability to be used for the different space applications and would allow combining the deterministic avionics with the high speed payload network in a spacecraft [1].Introducing the time-triggered principle to Ethernet allows combining the open industry standard IEE802.3 Ethernet currently use in almost all GSE platforms, with full control of latency and jitter of the time-triggered approach. To allow the time-triggered data flow over Ethernet, a network- wide synchronization time-base has to be established to allow deriving all network events on a globally known time which is typically done in software in almost all spacecrafts. The additional synchronization service of Time-triggered Ethernet has been implemented as additional quality of service (QoS) on layer 2 of the ISO/OSI network model and been standardized in the SAE AS6802 [3].Within a launcher, the communication system ensured the data exchanges between avionic functions during all phases of the launcher lifecycle which is composed of three areas: AIT operations, ground phase and flight phase. To ensure the use of a single network for the different phases, the network needs to support features like the

  4. Torque Control of a Rehabilitation Teaching Robot Using Magneto-Rheological Fluid Clutches

    Science.gov (United States)

    Hakogi, Hokuto; Ohaba, Motoyoshi; Kuramochi, Naimu; Yano, Hidenori

    A new robot that makes use of MR-fluid clutches for simulating torque is proposed to provide an appropriate device for training physical therapy students in knee-joint rehabilitation. The feeling of torque provided by the robot is expected to correspond to the torque performance obtained by physical therapy experts in a clinical setting. The torque required for knee-joint rehabilitation, which is a function of the rotational angle and the rotational angular velocity of a knee movement, is modeled using a mechanical system composed of typical spring-mass-damper elements. The robot consists of two MR-fluid clutches, two induction motors, and a feedback control system. In the torque experiments, output torque is controlled using the spring and damper coefficients separately. The values of these coefficients are determined experimentally. The experimental results show that the robot would be suitable for training physical therapy students to experience similar torque feelings as needed in a clinical situation.

  5. CDIO-Concept for Enginering Education in Fluid Power, Motion Control and Mechatronic Design

    DEFF Research Database (Denmark)

    Conrad, Finn; Sørensen, Torben

    2006-01-01

    of mechatronics solutions with fluid power actuators for motion control of machines and robots. The idea of CDIO-Concept is to take care of that the students are learning by doing and learning while doing when the students are active to generate new products and solutions by going through the phases from...... mechatronics design, and advantages as well as challenges are identified and discussed. An IT-tool concept for modelling, simulation and design of mechatronic products and systems is proposed....

  6. Mortality studies of machining fluid exposure in the automobile industry. IV: A case-control study of lung cancer.

    Science.gov (United States)

    Schroeder, J C; Tolbert, P E; Eisen, E A; Monson, R R; Hallock, M F; Smith, T J; Woskie, S R; Hammond, S K; Milton, D K

    1997-05-01

    Machining fluids are diverse products that contain numerous additives and contaminants, including polycyclic aromatic hydrocarbons. Studies treating machining fluids as an aggregate exposure have found both positive and negative associations with lung cancer. In this nested case-control study of automotive workers (667 cases and 3,041 matched controls), individual estimates of exposure quantity and duration for specific classes of machining fluids were derived. An inverse dose-response relationship was found between synthetic machining fluids and lung cancer mortality, with an odds ratio of 0.6 (95% CI = 0.4, 0.8) for the highest level of lifetime exposure. The relationship was strongest for recent exposures. There was little evidence of an association with soluble or straight oil machining fluids. Risks were inconsistently elevated in workers exposed to aluminum. Results from this study provide strong evidence that exposure to machining fluids is not associated with an increased risk of lung cancer mortality in automotive workers.

  7. Tutorial on Feedback Control of Flows, Part I: Stabilization of Fluid Flows in Channels and Pipes

    Directory of Open Access Journals (Sweden)

    Ole M. Aamo

    2002-07-01

    Full Text Available The field of flow control has picked up pace over the past decade or so, on the promise of real-time distributed control on turbulent scales being realizable in the near future. This promise is due to the micromachining technology that emerged in the 1980s and developed at an amazing speed through the 1990s. In lab experiments, so called micro-electro-mechanical systems (MEMS that incorporate the entire detection-decision-actuation process on a single chip, have been batch processed in large numbers and assembled into flexible skins for gluing onto body-fluid interfaces for drag reduction purposes. Control of fluid flows span a wide variety of specialities. In Part I of this tutorial, we focus on the problem of reducing drag in channel and pipe flows by stabilizing the parabolic equilibrium profile using boundary feedback control. The control strategics used for this problem include classical control, based on the Nyquist criteria, and various optimal control techniques (H2, H-Infinity, as well as applications of Lyapunov stability theory.

  8. Computational Fluid Dynamics Simulation Study of Active Power Control in Wind Plants

    Energy Technology Data Exchange (ETDEWEB)

    Fleming, Paul; Aho, Jake; Gebraad, Pieter; Pao, Lucy; Zhang, Yingchen

    2016-08-01

    This paper presents an analysis performed on a wind plant's ability to provide active power control services using a high-fidelity computational fluid dynamics-based wind plant simulator. This approach allows examination of the impact on wind turbine wake interactions within a wind plant on performance of the wind plant controller. The paper investigates several control methods for improving performance in waked conditions. One method uses wind plant wake controls, an active field of research in which wind turbine control systems are coordinated to account for their wakes, to improve the overall performance. Results demonstrate the challenge of providing active power control in waked conditions but also the potential methods for improving this performance.

  9. Fluid intelligence as a mediator of the relationship between executive control and balanced time perspective

    Directory of Open Access Journals (Sweden)

    Marcin Zajenkowski

    2016-11-01

    Full Text Available This study examined the cognitive foundations of the balanced time perspective (BTP proposed by Zimbardo and Boyd. Although BTP is defined as the mental ability to switch effectively between different temporal perspectives, its connection with cognitive functioning has not yet been established. We addressed this by exploring the relationships between time perspectives and both fluid intelligence (measured with Raven’s and Cattell’s tests and executive control (go/no-go and antisaccade tasks. An investigation conducted among Polish adults (N=233 revealed that more balanced TP profile was associated with higher fluid intelligence, and higher executive control. Moreover, we found that the relationship between executive control and BTP was completely mediated by fluid intelligence with the effect size (the ratio of the indirect effect to the total effect of .75, which suggests that cognitive abilities play an important role in adoption of temporal balance. The findings have relevance to time perspective theory as they provide valuable insight into the mechanisms involved in assigning human experience to certain time frames.

  10. Fluid Intelligence as a Mediator of the Relationship between Executive Control and Balanced Time Perspective.

    Science.gov (United States)

    Zajenkowski, Marcin; Stolarski, Maciej; Witowska, Joanna; Maciantowicz, Oliwia; Łowicki, Paweł

    2016-01-01

    This study examined the cognitive foundations of the balanced time perspective (BTP) proposed by Zimbardo and Boyd (1999). Although BTP is defined as the mental ability to switch effectively between different temporal perspectives, its connection with cognitive functioning has not yet been established. We addressed this by exploring the relationships between time perspectives and both fluid intelligence (measured with Raven's and Cattell's tests) and executive control (Go/No-go and anti-saccade tasks). An investigation conducted among Polish adults (N = 233) revealed that more balanced TP profile was associated with higher fluid intelligence, and higher executive control. Moreover, we found that the relationship between executive control and BTP was completely mediated by fluid intelligence with the effect size (the ratio of the indirect effect to the total effect) of 0.75, which suggests that cognitive abilities play an important role in adoption of temporal balance. The findings have relevance to time perspective theory as they provide valuable insight into the mechanisms involved in assigning human experience to certain time frames.

  11. Fluid Shifts

    Science.gov (United States)

    Stenger, M. B.; Hargens, A. R.; Dulchavsky, S. A.; Arbeille, P.; Danielson, R. W.; Ebert, D. J.; Garcia, K. M.; Johnston, S. L.; Laurie, S. S.; Lee, S. M. C.; Liu, J.; Macias, B.; Martin, D. S.; Minkoff, L.; Ploutz-Snyder, R.; Ribeiro, L. C.; Sargsyan, A.; Smith, S. M.

    2017-01-01

    Introduction. NASA's Human Research Program is focused on addressing health risks associated with long-duration missions on the International Space Station (ISS) and future exploration-class missions beyond low Earth orbit. Visual acuity changes observed after short-duration missions were largely transient, but now more than 50 percent of ISS astronauts have experienced more profound, chronic changes with objective structural findings such as optic disc edema, globe flattening and choroidal folds. These structural and functional changes are referred to as the visual impairment and intracranial pressure (VIIP) syndrome. Development of VIIP symptoms may be related to elevated intracranial pressure (ICP) secondary to spaceflight-induced cephalad fluid shifts, but this hypothesis has not been tested. The purpose of this study is to characterize fluid distribution and compartmentalization associated with long-duration spaceflight and to determine if a relation exists with vision changes and other elements of the VIIP syndrome. We also seek to determine whether the magnitude of fluid shifts during spaceflight, as well as any VIIP-related effects of those shifts, are predicted by the crewmember's pre-flight status and responses to acute hemodynamic manipulations, specifically posture changes and lower body negative pressure. Methods. We will examine a variety of physiologic variables in 10 long-duration ISS crewmembers using the test conditions and timeline presented in the figure below. Measures include: (1) fluid compartmentalization (total body water by D2O, extracellular fluid by NaBr, intracellular fluid by calculation, plasma volume by CO rebreathe, interstitial fluid by calculation); (2) forehead/eyelids, tibia, and calcaneus tissue thickness (by ultrasound); (3) vascular dimensions by ultrasound (jugular veins, cerebral and carotid arteries, vertebral arteries and veins, portal vein); (4) vascular dynamics by MRI (head/neck blood flow, cerebrospinal fluid

  12. A Promising Material by Using Residue Waste from Bisphenol A Manufacturing to Prepare Fluid-Loss-Control Additive in Oil Well Drilling Fluid

    Directory of Open Access Journals (Sweden)

    Zhi-Lei Zhang

    2013-01-01

    Full Text Available The residues mixture from Bisphenol A manufacturing process was analyzed. Fourier transform infrared (FTIR spectroscopy, gas chromatography-mass spectrometry (GC-MS, and nuclear magnetic resonance (NMR were used to characterize the residues. The results indicated that the residues were complex mixture of several molecules. 3-(2-Hydroxyphenyl-1,1,3-trimethyl-2,3-dihydro-1H-inden-5-ol and phenol were the main components of the residues. The technical feasibility of using it as phenol replacement in fluid-loss-control additive production was also investigated. The fluid-loss-control capacity of the novel additive was systematically investigated. It was discovered that the well fluid-loss performance of the prepared additive can be achieved, especially at high temperature.

  13. Smooth and robust solutions for Dirichlet boundary control of fluid-solid conjugate heat transfer problems

    KAUST Repository

    Yan, Yan

    2015-01-01

    We study a new optimization scheme that generates smooth and robust solutions for Dirichlet velocity boundary control (DVBC) of conjugate heat transfer (CHT) processes. The solutions to the DVBC of the incompressible Navier-Stokes equations are typically nonsmooth, due to the regularity degradation of the boundary stress in the adjoint Navier-Stokes equations. This nonsmoothness is inherited by the solutions to the DVBC of CHT processes, since the CHT process couples the Navier-Stokes equations of fluid motion with the convection-diffusion equations of fluid-solid thermal interaction. Our objective in the CHT boundary control problem is to select optimally the fluid inflow profile that minimizes an objective function that involves the sum of the mismatch between the temperature distribution in the fluid system and a prescribed temperature profile and the cost of the control.Our strategy to resolve the nonsmoothness of the boundary control solution is based on two features, namely, the objective function with a regularization term on the gradient of the control profile on both the continuous and the discrete levels, and the optimization scheme with either explicit or implicit smoothing effects, such as the smoothed Steepest Descent and the Limited-memory Broyden-Fletcher-Goldfarb-Shanno (L-BFGS) methods. Our strategy to achieve the robustness of the solution process is based on combining the smoothed optimization scheme with the numerical continuation technique on the regularization parameters in the objective function. In the section of numerical studies, we present two suites of experiments. In the first one, we demonstrate the feasibility and effectiveness of our numerical schemes in recovering the boundary control profile of the standard case of a Poiseuille flow. In the second one, we illustrate the robustness of our optimization schemes via solving more challenging DVBC problems for both the channel flow and the flow past a square cylinder, which use initial

  14. Status of the Control System for the CLAS Detector at Jefferson Lab

    Energy Technology Data Exchange (ETDEWEB)

    T. Carroll; A. Gilmer; M. Vineyard; T. Auger; W. Brooks; S. Fabbro; A. Freyberger; M. Ito; B. Madre; Y. Patois; S. Philips; M. Swynghedauw; J. Tang

    1997-11-01

    A control system for Hall B at the Thomas Jefferson National Accelerator Facility is being developed within the framework of the Experimental Physics and Industrial Control System (EPICS). The Hall B equipment currently under EPICS control include numerous beam line devices, high voltage supplies, detector gas systems, and safety systems. The status of the control system is described.

  15. Active vibration control of hybrid smart structures featuring piezoelectric films and electrorheological fluids

    Science.gov (United States)

    Choi, Seung-Bok; Park, Yong-Kun; Cheong, ChaeCheon

    1996-05-01

    This paper presents a proof-of-concept investigation on an active vibration control of a hybrid smart structure (HSS) consisting of a piezoelectric film actuator (PFA) and an electro- rheological fluid actuator (ERFA). Firstly, an HSS beam is constructed by inserting a starch- based electro-rheological fluid into a hollow composite beam and perfectly bonding two piezoelectric films on the upper and lower surfaces of the structure as an actuator and as a sensor, respectively. As for the PFA, a neuro-sliding mode controller (NSC) incorporating neural networks with the concept of sliding mode control is formulated. On the other hand, the control scheme for the ERFA is developed as a function of excitation frequencies on the basis of field-dependent frequency responses. An experimental implementation for the PFA and ERFA is then established to perform an active vibration control of the HSS in the transient and forced vibrations. Both the increment of damping ratios and the suppression of tip deflections are evaluated in order to demonstrate control effectiveness of the PFA, the ERFA, and the hybrid actuation. The experimental results exhibit a superior ability of the hybrid actuation system to tailor elastodynamic responses of the HSS rather than a single class of actuation system alone.

  16. Colorimetric measurements as control elements in wood conservation status

    Directory of Open Access Journals (Sweden)

    Ovidia Soto-Martín

    2015-02-01

    Full Text Available This paper is a methodological proposal for the study of altarpieces on wooden supports. The process was implemented to study the altarpiece of San Antonio de Padua in Garachico, Tenerife. For this, we conducted a review of key aspects appropriate to the discipline of wood identification carried out by macroscopic examination and for the characterization of the status of deterioration by colorimetric analysis. For the evaluation of the wood conservation status, the samples were subjected for the first time to colorimetric measurement. As a result we have created an online database to provide information for conservation professionals permitting them to design a proposal for preventive conservation and intervention individually for each object.

  17. Fluid-dependent anisotropy and experimental measurements in synthetic porous rocks with controlled fracture parameters

    Science.gov (United States)

    Ding, Pinbo; Di, Bangrang; Wei, Jianxin; Li, Xiangyang; Deng, Yinghua

    2014-02-01

    In this study, we analyse the influence of fluid on P- and S-wave anisotropy in a fractured medium. Equivalent medium theories are used to describe the relationship between the fluid properties and the rock physics characteristics in fractured rocks, and P-wave and S-wave velocities and anisotropy are considered to be influenced by fluid saturation. However, these theoretical predictions require experimental measurement results for calibration. A new construction method was used to create synthetic rock samples with controlled fracture parameters. The new construction process provides synthetic rocks that have a more realistic mineral composition, porous structure, cementation and pressure sensitivity than samples used in previous research on fractured media. The synthetic rock samples contain fractures which have a controlled distribution, diameter, thickness and fracture density. In this study, the fracture diameter was about 4 mm, the thickness of fractures was about 0.06 mm, and the fracture density in the two fractured rock samples was about 3.45%. SEM images show well-defined penny-shaped fractures of 4 mm in length and 0.06 mm in width. The rock samples were saturated with air, water and oil, and P- and S-wave velocities were measured in an ultrasonic measurement system. The laboratory measurement results show that the P-wave anisotropy is strongly influenced by saturated fluid, and the P-wave anisotropy parameter, ɛ, has a much larger value in air saturation than in water and oil saturations. The S-wave anisotropy decreases when the samples are saturated with oil, which can be caused by high fluid viscosity. In the direction perpendicular to the fractures (the 0° direction), shear-wave splitting is negligible, and is similar to the blank sample without fractures, as expected. In the direction parallel to the fractures (the 90° direction) shear-wave splitting is significant. The fractured rock samples show significant P- and S-wave anisotropy caused by

  18. Control of convergence in a computational fluid dynamic simulation using fuzzy logic

    Institute of Scientific and Technical Information of China (English)

    刘训良; 陶文铨; 郑平; 何雅玲; 王秋旺

    2002-01-01

    A fuzzy control method was used to accelerate iteration convergence in numerical fluid dynamic simulation using SIMPLER algorithm. The residual ratio of momentum or energy equation between two successive iterations was used as the input variable. A fuzzy logic algorithm was developed in order to obtain the relative increment of the under-relaxation factor and its new value was then used for the next iteration. The algorithm was tested by four benchmark problems. In all cases considered, when the fuzzy control logic was used, convergence was achieved with nearly the minimum number of iterations, showing the feasibility of the proposed method.

  19. Creep cavitation bands control porosity and fluid flow in lower crustal shear zones

    Energy Technology Data Exchange (ETDEWEB)

    Menegon, Luca; Fusseis, Florian; Stunitz, Holger; Xiao, Xianghui

    2015-03-01

    Shear zones channelize fluid flow in Earth’s crust. However, little is known about deep crustal fluid migration and how fluids are channelized and distributed in a deforming lower crustal shear zone. This study investigates the deformation mechanisms, fluid-rock interaction, and development of porosity in a monzonite ultramylonite from Lofoten, northern Norway. The rock was deformed and transformed into an ultramylonite under lower crustal conditions (temperature = 700–730 °C, pressure = 0.65–0.8 GPa). The ultramylonite consists of feldspathic layers and domains of amphibole + quartz + calcite, which result from hydration reactions of magmatic clinopyroxene. The average grain size in both domains is <25 mm. Microstructural observations and electron backscatter diffraction analysis are consistent with diffusion creep as the dominant deformation mechanism in both domains. Festoons of isolated quartz grains define C'-type bands in feldspathic layers. These quartz grains do not show a crystallographic preferred orientation. The alignment of quartz grains is parallel to the preferred elongation of pores in the ultramylonites, as evidenced from synchrotron X-ray microtomography. Such C'-type bands are interpreted as creep cavitation bands resulting from diffusion creep deformation associated with grain boundary sliding. Mass-balance calculation indicates a 2% volume increase during the protolith-ultramylonite transformation, which is consistent with synkinematic formation of creep cavities producing dilatancy. Thus, this study presents evidence that creep cavitation bands may control deep crustal porosity and fluid flow. Nucleation of new phases in creep cavitation bands inhibits grain growth and enhances the activity of grain size–sensitive creep, thereby stabilizing strain localization in the polymineralic ultramylonites.

  20. Heat Transfer Fluid Temperature Control in a Thermoelectric Solar Power Plant

    Directory of Open Access Journals (Sweden)

    Lourdes A. Barcia

    2017-07-01

    Full Text Available Thermoelectric solar plants transform solar energy into electricity. Unlike photovoltaic plants, the sun’s energy heats a fluid (heat transfer fluid (HTF and this, in turn, exchanges its energy, generating steam. Finally, the steam generates electricity in a Rankine cycle. One of the main advantages of this double conversion (sun energy to heat in the HTF-Rankine cycle is the fact that it facilitates energy storage without using batteries. It is possible to store the heat energy in melted salts in such a way that this energy will be recovered when necessary, i.e., during the night. These molten salts are stored in containers in a liquid state at high temperature. The HTF comes into the solar field at a given temperature and increases its energy thanks to the solar collectors. In order to optimize the sun to HTF energy transference, it is necessary to keep an adequate temperature control of the fluid at the output of the solar fields. This paper describes three different algorithms to control the HTF output temperature.

  1. Wind-induced vibration control of Hefei TV tower with fluid viscous damper

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhiqiang; Aiqun LI; Jianping HE; Jianlei WANG

    2009-01-01

    The Hefei TV tower is taken as an analytical case to examine the control method with a fluid viscous damper under wind load fluctuation. Firstly, according to the random vibration theory, the effect of fluctuating wind on the tower can be modeled as a 19-dimensional correlated random process, and the wind-induced vibration analysis of the tower subjected to dynamic wind load was further obtained. On the basis of the others' works, a bi-model dynamic model is proposed. Finally, a dynamic model is proposed to study the wind-induced vibration control analysis using viscous fluid dampers, and the optimal damping coefficient is obtained regarding the wind-induced response of the upper turret as optimization objectives. Analysis results show that the maximum peak response of the tower under dynamic wind load is far beyond the allowable range of the code. The wind-induced responses and the wind vibration input energy of the tower are decreased greatly by using a fluid viscous damper, and the peak acceleration responses of the upper turret is reduced by 43.4%.

  2. Design and Testing of a Breadboard Electrical Power Control Unit for the Fluid Combustion Facility Experiment

    Science.gov (United States)

    Kimnach, Greg L.; Lebron, Ramon C.

    1999-01-01

    The Fluid Combustion Facility (FCF) Project and the Power Technology Division at the NASA Glenn Research Center (GRC) at Lewis Field in Cleveland, OH along with the Sundstrand Corporation in Rockford, IL are jointly developing an Electrical Power Converter Unit (EPCU) for the Fluid Combustion Facility to be flown on the International Space Station (ISS). The FCF facility experiment contains three racks: A core rack, a combustion rack, and a fluids rack. The EPCU will be used as the power interface to the ISS 120V(sub dc) power distribution system by each FCF experiment rack which requires 28V(sub dc). The EPCU is a modular design which contains three 120V(sub dc)-to-28V(sub dc) full-bridge, power converters rated at 1 kW(sub e) each bus transferring input relays and solid-state, current-limiting input switches, 48 current-limiting, solid-state, output switches; and control and telemetry hardware. The EPCU has all controls required to autonomously share load demand between the power feeds and--if absolutely necessary--shed loads. The EPCU, which maximizes the usage of allocated ISS power and minimizes loss of power to loads, can be paralleled with other EPCUs. This paper overviews the electrical design and operating characteristics of the EPCU and presents test data from the breadboard design.

  3. Microbiological quality and quality control of purified water and ultrapure dialysis fluids for online hemodiafiltration in routine clinical practice.

    NARCIS (Netherlands)

    Penne, E.L.; Visser, L.; Dorpel, M.A. van den; Weerd, N.C. van der; Mazairac, A.H.; Jaarsveld, B.C. van; Koopman, M.G.; Vos, P.; Feith, G.W.; Kremer Hovinga, T.K.; Hamersvelt, H.W. van; Wauters, I.M.; Bots, M.L.; Nube, M.J.; Wee, P.M. ter; Blankestijn, P.J.; Grooteman, M.P.C.

    2009-01-01

    During online hemodiafiltration, patients are directly infused with sterile substitution solutions to maintain fluid balance. Adequate water treatment and a well-organized quality control process are essential to provide non-pyrogenic fluids with consistent optimal quality. We sought to assess water

  4. Microbiological quality and quality control of purified water and ultrapure dialysis fluids for online hemodiafiltration in routine clinical practice

    NARCIS (Netherlands)

    Penne, E. Lars; Visser, Linda; van den Dorpel, Marinus A.; van der Weerd, Neelke C.; Mazairac, Albert H. A.; van Jaarsveld, Brigit C.; Koopman, Marion G.; Vos, Pieter; Feith, Geert W.; Kremer Hovinga, T; van Hamersvelt, Henk W.; Wauters, Inge M.; Bots, Michiel L.; Nube, Menso J.; ter Wee, Piet M.; Blankestijn, Peter J.; Grooteman, Muriel P. C.

    2009-01-01

    During online hemodiafiltration, patients are directly infused with sterile substitution solutions to maintain fluid balance. Adequate water treatment and a well-organized quality control process are essential to provide non-pyrogenic fluids with consistent optimal quality. We sought to assess water

  5. Lapses in Sustained Attention and Their Relation to Executive Control and Fluid Abilities: An Individual Differences Investigation

    Science.gov (United States)

    Unsworth, Nash; Redick, Thomas S.; Lakey, Chad E.; Young, Diana L.

    2010-01-01

    A latent variable analysis was conducted to examine the nature of individual differences in lapses of attention and their relation to executive and fluid abilities. Participants performed a sustained attention task along with multiple measures of executive control and fluid abilities. Lapses of attention were indexed based on the slowest reaction…

  6. Status of dual control theory. [stochastic decision making

    Science.gov (United States)

    Tse, E.

    1975-01-01

    Theoretical studies of decision making and stochastic processes are discussed. Several approaches are described for an improved performing control method. It is shown that control performance is highly dependent on the knowledge of the unknown parameters in the system.

  7. Leveraging fluid-structure interaction for passive control of flapping locomotion

    Science.gov (United States)

    Ohh, Chan-Ye; Huang, Yangyang; Wen, Ziteng; Kanso, Eva; Luhar, Mitul

    2016-11-01

    While many living organisms employ active feedback control during flapping locomotion, there is increasing evidence to suggest that passive fluid-structure interactions also play a central role in dictating stability and efficiency. The current project seeks to experimentally evaluate and numerically verify the rotational stability and dynamics of a rigid Λ-flyer oscillating up-and-down in a rest fluid. We explore the dynamic behavior of the flyer in terms of three dimensionless parameters: opening angle, oscillation amplitude, and acceleration of the flyer. Within the parameter ranges tested, we identify four types of behavior: periodic rotation, chaotic dynamics, stable behavior (concave down position), and bistability (concave up and down position). The emergence of periodic and chaotic rotation depends primarily on the oscillation amplitude of the flyer, whereas transition from stability to bistability is dependent on both the amplitude and acceleration. The transition to bistability occurs at a constant ratio of drag to gravity, indicating that the stabilizing effect is hydrodynamic.

  8. Molecular Mechanisms of the Lubrucating Function of the Synovial Fluid Control

    Directory of Open Access Journals (Sweden)

    Dmitry A. Antonov

    2013-12-01

    Full Text Available The author in his review presents up-to-date information, concerning the composition and properties of human synovial fluid with an emphasis on detailed description of the molecular mechanisms of the lubricating function control. Three main groups of molecules: (surface-active phospholipids (1, hyaluronic acid (2, and proteins group SZP/lubricine (3, were described in synovial fluid being able to support lubrication; the latter group was considered as the main biopolymers, ensuring the boundary lubrication. On author’s opinion, the modern practice of viscosupplementation is not fully functional, since it did not restore the function of the boundary lubrication, lost in the osteoarthritis progression. Besides the need to correct the composition of current drugs for viscosupplementary therapy, the ensuring of lubricating properties of tissue engineering constructs and media to grow cartilage tissue was in vitro attributed to the practical tasks of joints regenerative biomedicine.

  9. Cylindrical Magnetorheological Fluid Variable Transmission Controlled by Shape-Memory Alloy

    Directory of Open Access Journals (Sweden)

    Song Chen

    2012-01-01

    Full Text Available Centrifugal fan is an important component of a ventilation system in a nuclear power plant. In this paper, we proposed a magnetorheological speed-adjustment system controlled by shape-memory alloy for centrifugal fan. A theoretical analysis of the effect of the applied magnetic field on the viscoplastic flow between two cylinders in the speed-adjustment system is presented. The expressions for the velocity in viscoplastic flow and the torque transmitted by MR fluids are derived. A sliding mode SMA switch is proposed to modify the magnetic field acting on working gap under thermal effect. The results indicate that with the increases of applied magnetic field, the torque transmitted by MR fluid goes up rapidly.

  10. Numerical Modeling of the Fluid Flow in Continuous Casting Tundish with Different Control Devices

    Directory of Open Access Journals (Sweden)

    Zhu He

    2013-01-01

    Full Text Available Numerical simulations were conducted to study the melt flow under the influence of control devices in a T-type two-strand bloom caster tundish via the open source Computational Fluid Dynamics software OpenFOAM. Three different cases were studied: a bare tundish, a tundish with two pairs of baffles, and a tundish equipped with a turbulence inhibitor and a pair of baffles. Turbulence inhibitor and baffles arrangement showed an improvement of the fluid flow characteristics, yielding lower values of dead volume and higher values of plug flow. With a turbulence inhibitor, the velocity of metal which flows directly toward the tundish floor is smaller and the turbulence kinetic energy of the melt top surface is lower than the other two arrangements.

  11. 2nd Symposium on Fluid-Structure-Sound Interactions and Control

    CERN Document Server

    Liu, Yang; Huang, Lixi; Hodges, Dewey

    2014-01-01

    With rapid economic and industrial development in China, India and elsewhere, fluid-related structural vibration and noise problems are widely encountered in many fields, just as they are in the more developed parts of the world, causing increasingly grievous concerns. Turbulence clearly has a significant impact on many such problems. On the other hand, new opportunities are emerging with the advent of various new technologies, such as signal processing, flow visualization and diagnostics, new functional materials, sensors and actuators, etc. These have revitalized interdisciplinary research activities, and it is in this context that the 2nd symposium on fluid-structure-sound interactions and control (FSSIC) was organized. Held in Hong Kong (May 20-21, 2013) and Macau (May 22-23, 2013), the meeting brought together scientists and engineers working in all related branches from both East and West and provided them with a forum to exchange and share the latest progress, ideas and advances and to chart the fronti...

  12. Electro-Active Device Using Radial Electric Field Piezo-Diaphragm for Control of Fluid Movement

    Science.gov (United States)

    Bryant, Robert G. (Inventor); Working, Dennis C. (Inventor)

    2005-01-01

    A fluid-control electro-active device includes a piezo-diaphragm made from a ferroelectric material sandwiched by first and second electrode patterns configured to introduce an electric field into the ferroelectric material when voltage is applied thereto. The electric field originates at a region of the ferroelectric material between the first and second electrode patterns, and extends radially outward from this region of the ferroelectric material and substantially parallel to the plane of the ferroelectric material. The piezo-diaphragm deflects symmetrically about this region in a direction substantially perpendicular to the electric field. An annular region coupled to and extending radially outward from the piezo-diaphragm perimetrically borders the piezo-diaphragm, A housing is connected to the region and at least one fluid flow path with piezo-diaphragm disposed therein.

  13. Model-based drug administration : current status of target-controlled infusion and closed-loop control

    NARCIS (Netherlands)

    Kuizenga, Merel H.; Vereecke, Hugo E. M.; Struys, Michel M. R. F.

    2016-01-01

    Purpose of review Drug administration might be optimized by incorporating pharmacokinetic-dynamic (PK/PD) principles and control engineering theories. This review gives an update of the actual status of target-controlled infusion (TCI) and closed-loop computer-controlled drug administration and the

  14. Control of electro-rheological fluid based resistive torque elements for use in active rehabilitation devices

    Science.gov (United States)

    Nikitczuk, Jason; Weinberg, Brian; Mavroidis, Constantinos

    2007-04-01

    In this paper we present control algorithms for novel electro-rheological fluid based resistive torque generation elements that will be used to drive the joint of a new type of portable and controllable active knee rehabilitation orthotic device (AKROD) for iso-inertial, isokinetic, and isometric exercising as well as gait retraining. The AKROD is composed of straps and rigid components for attachment to the leg, with a central hinge mechanism where a gear system is connected. The key features of AKROD include: a compact, lightweight design with highly tunable torque capabilities through a variable damper component, full portability with on-board power, control circuitry, and sensors (encoder and torque), and real-time capabilities for closed loop computer control for optimizing gait retraining. The variable damper component is achieved through an electro-rheological fluid (ERF) element that connects to the output of the gear system. Using the electrically controlled rheological properties of ERFs, compact brakes capable of supplying high resistive and controllable torques are developed. In this project, a prototype for the AKROD has been developed and tested. The AKROD's ERF resistive actuator was tested in laboratory experiments using a custom-made ERF testing apparatus (ETA). ETA provides a computer-controlled environment to test ERF brakes and actuators in various conditions and scenarios including emulating the interaction between human muscles involved with the knee and the AKROD's ERF actuators/brakes. The AKROD's ERF resistive actuator was tested in closed loop torque control experiments. A hybrid (non-linear, adaptive) proportional-integral (PI) torque controller was implemented to achieve this goal.

  15. Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response

    Directory of Open Access Journals (Sweden)

    Dezerega Andrea

    2012-03-01

    Full Text Available Abstract Background Oxidative stress and matrix metalloproteinases -9 and -2 are involved in periodontal breakdown, whereas gingival crevicular fluid has been reported to reflect apical status. The aim of this study was to characterize oxidant balance and activity levels of MMP -2 and -9 in apical lesions and healthy periodontal ligament; and second, to determine whether potential changes in oxidant balance were reflected in gingival crevicular fluid from asymptomatic apical periodontitis (AAP-affected teeth at baseline and after endodontic treatment. Methods Patients with clinical diagnosis of AAP and healthy volunteers having indication of tooth extraction were recruited. Apical lesions and healthy periodontal ligaments, respectively, were homogenized or processed to obtain histological tissue sections. Matrix metalloproteinase -9 and -2 levels and/or activity were analyzed by Immunowestern blot, zymography and consecutive densitometric analysis, and their tissue localization was confirmed by immunohistochemistry. A second group of patients with AAP and indication of endodontic treatment was recruited. Gingival crevicular fluid was extracted from AAP-affected teeth at baseline, after endodontic treatment and healthy contralateral teeth. Total oxidant and antioxidant status were determined in homogenized tissue and GCF samples. Statistical analysis was performed using STATA v10 software with unpaired t test, Mann-Whitney test and Spearman's correlation. Results Activity of MMP-2 and MMP-9 along with oxidant status were higher in apical lesions (p Conclusions Apical lesions display an oxidant imbalance along with increased activity of matrix metalloproteinase-2 and -9 and might contribute to AAP progression. Oxidant imbalance can also be reflected in GCF from AAP-affected teeth and was restored to normal levels after conservative endodontic treatment. These mediators might be useful as potential biomarkers for chair-side complementary diagnostic

  16. Determinants of infant nutritional status in Dabat district, North Gondar, Ethiopia: A case control study

    National Research Council Canada - National Science Library

    Amarech Asratie Wubante

    2017-01-01

    .... Therefore, this study is aimed to assess determinants of infant nutritional status. Methods A community based nested case-control study was conducted from February to June 2013 in Dabat district...

  17. Gender and Socioeconomic Status in Relation to Weight Perception and Weight Control Behavior in Korean Adults

    National Research Council Canada - National Science Library

    Joh, Hee-Kyung; Oh, Juhwan; Lee, Hae-Jeung; Kawachi, Ichiro

    2013-01-01

    In Korea, obesity is more prevalent among men and lower socioeconomic groups. To explain this obesity disparity, we compared weight perception and weight control behavior across gender and socioeconomic status (SES...

  18. LQR Feedback Control Development for Wind Turbines Featuring a Digital Fluid Power Transmission System

    DEFF Research Database (Denmark)

    Pedersen, Niels Henrik; Johansen, Per; Andersen, Torben O.

    2016-01-01

    Research within digital fluid power (DFP) transmissions is receiving an increased attention as an alternative to conventional transmission technologies. The use of DFP displacement machines entail a need for applicable control algorithms. However, the design and analysis of controllers...... for such digital systems are complicated by its non-smooth behavior. In this paper a control design approach for a digital displacement machine® is proposed and a performance analysis of a wind turbine using a DFP transmission is presented. The performance evaluation is based on a dynamic model of the transmission...... invariant model. Using full-field flow wind profiles as input, the design approach and control performance is verified by simulation in the dynamic model of the wind turbine featuring the DFP transmission. Additionally, the performance is compared to that of the conventional NREL reference turbine...

  19. Predicting performance expectations from affective impressions: linking affect control theory and status characteristics theory.

    Science.gov (United States)

    Dippong, Joseph; Kalkhoff, Will

    2015-03-01

    Affect control theory (ACT) and status characteristics theory (SCT) offer separate and distinct explanations for how individuals interpret and process status- and power-relevant information about interaction partners. Existing research within affect control theory offers evidence that status and power are related to the affective impressions that individuals form of others along the dimensions of evaluation and potency, respectively. Alternately, status characteristics theory suggests that status and power influence interaction through the mediating cognitive construct of performance expectations. Although both theories have amassed an impressive amount of empirical support, research has yet to articulate theoretical and empirical connections between affective impressions and performance expectations. The purpose of our study is to address this gap. Elaborating a link between ACT and SCT in terms of their central concepts can serve as a stepping stone to improving the explanatory capacity of both theories, while providing a potential bridge by which they can be employed jointly.

  20. Control of Quantum Fluid Dynamics and Adaptive Phase Compensation for Laser Propagation in Turbulence

    Science.gov (United States)

    Gustafsson, Jonathan; Sritharan, Sivaguru S.

    2015-11-01

    Equations of High Energy Laser propagation in a turbulent medium and the equations of quantum fluid dynamics are connected through a mathematical transformation. In this way the problem of adaptive phase compensation can be phrased as an initial velocity control problem for quantum fluid dynamics. The quantum hydrodynamics equation can be derived by applying the Madelung transformation to the time-dependent linear or nonlinear Schrödinger equation. The resulting equations are similar to incompressible Euler equations with an additional term denoted the quantum pressure term. The quantum hydrodynamics equation can thus be a good way to understand adaptive optics and laser propagation through the atmosphere. A Riemann solver within the Clawpack framework has been developed. An initial value optimization problem will be solved using adjoint methods. The initial phase can be controlled when the beam leaves the laser appartus. The control method can also be coupled to a Navier-Stokes solver in order to study thermal blooming where the laser heats the air and changes the index of refraction. The change in refractive index will in turn affect the propagation of the Laser beam. Using optimal control techniques, it is possible to adjust the beam in order to compensate for the heating.

  1. Torsional Vibration Semiactive Control of Drivetrain Based on Magnetorheological Fluid Dual Mass Flywheel

    Directory of Open Access Journals (Sweden)

    Qing-hua Zu

    2015-01-01

    Full Text Available The damping characteristics of the traditional dual mass flywheel (DMF cannot be changed and can only meet one of the damping requirements. Given that the traditional DMF cannot avoid the resonance interval in start/stop conditions, it tends to generate high-resonance amplitude, which reduces the lifetime of a vehicle’s parts and leads to vehicle vibration and noise. The problems associated with the traditional DMF can be solved through the magnetorheological fluid dual mass flywheel (MRF-DMF, which was designed in this study with adjustable damping performance under different conditions. The MRF-DMF is designed based on the rheological behavior of the magnetorheological fluid (MRF, which can be changed by magnetic field strength. The damping torque of the MRF-DMF, which is generated by the MRF effect, is derived in detail. Thus, the cosimulation between the drivetrain model built in AMESim and the control system model developed in Simulink is conducted. The controller of MRF-DMF is developed, after which the torsional vibration control test of drivetrain is carried out. The cosimulation and test results indicate that MRF-DMF with the controller effectively isolates torque fluctuation of the engine in the driving condition and exhibits high performance in suppressing the resonance amplitude in the start/stop conditions.

  2. Low order modelling for feedback control of fluid flows around complex geometries

    Science.gov (United States)

    Dellar, Oliver; Jones, Bryn; Department of Automatic Control; Systems Engineering Collaboration

    2015-11-01

    The majority of goods transportation vehicles' power is consumed in overcoming aerodynamic drag. Reduction in pressure drag via feedback control could have significant economic and environmental effects on CO2 emissions, and reduce fatigue on the body by suppressing vortex shedding. The difficulty in designing such controllers lies in obtaining models suited to modern control design methods, which are necessarily of much lesser complexity than typical Computational Fluid Dynamics (CFD) models, or models derived from immediate spatial discretisation of the Navier-Stokes equations. This work develops an approach for modelling fluid flows using frequency response data generated for individual computational node sub-systems that result from a CFD type spatial discretisation of the governing equations. Input-to-sensor frequency response data for the overall system are then computed by forming interconnections between adjacent nodes via a Redheffer Star Product operation, from which one typically observes low-order dynamics. With this data, a low-order model can be identified and used for controller design. This method avoids manipulating large matrices and is therefore computationally efficient and numerically well-conditioned. It can be readily applied to complex geometry flows.

  3. Chaos control and impact suppression in rotor-bearing system using magnetorheological fluid

    Science.gov (United States)

    Piccirillo, V.; Balthazar, J. M.; Tusset, A. M.

    2015-11-01

    In this paper a general dynamic model of a rotor-bearing system using magnetorheological fluid (MR) is presented. The mathematical model of the rotor-bearing system results from a Jeffcott rotor with two-degrees of freedom and discontinuous supports. The effect of magnetorheological fluid on vibration is investigated based on a model of a modified LuGre dynamical friction model. A comparison with equivalent rotor-bearing system is made to verify the contribution of MR in this system. In this study two different implementations of the control procedure are presented, one eliminating the chaotic behavior and the second suppressing the unbalancing vibration so as to avoid impact in rotor-bearing system. First, to control the undesirable chaos in rotor-bearing system a damped passive control methodology is used. On the other hand, to suppressing the impact vibration, the Fuzzy Logic Control is considered. Results demonstrate that undesirable behaviors of rotor can be avoided by varying the damping force.

  4. The Effect of Photodynamic Therapy and Diode Laser as Adjunctive Periodontal Therapy on the Inflammatory Mediators Levels in Gingival Crevicular Fluid and Clinical Periodontal Status

    Science.gov (United States)

    Teymouri, Faraz; Farhad, Shirin Zahra; Golestaneh, Hedayatollah

    2016-01-01

    Statement of the Problem The presence of bacterial biofilms is the major cause of gingivitis and periodontitis, their mechanical removal is not often enough. Therefore, laser therapy and photodynamic therapy can be effective as adjunctive treatment. Purpose This study aimed to evaluate the impact of these treatments on the level of gingival crevicular fluid (GCF), inflammatory mediators, and periodontal clinical status. Materials and Method In this clinical trial, three quadrants were studied in 12 patients with chronic periodontitis aged 30-60 years. The clinical parameters were recorded and GCF samples were taken. After the first phase of periodontal treatment, one of the three quadrants was determined as the control group, one was treated by diode laser, and one underwent photodynamic therapy. The clinical parameters were recorded 2 and 6 weeks later. The data were statistically analyzed by using Friedman, ANOVA, and LSD post-test. Results Significant reduction was observed over time in the level of Interleukin-1β (IL-1β), Interleukin-17 (IL-17), clinical attachment loss, and pocket depth in the three treatment groups (p< 0.000). The three treatment methods significantly reduced the IL-1β and IL-17 at the baseline, up to 2 weeks, and 2-6 weeks (p< 0.05). Diode laser and photodynamic therapy significantly decreased the average bleeding on probing over time (p< 0.000 and p< 0.002, respectively). Conclusion Laser and photodynamic therapy reduced the inflammatory mediators (IL-1β and IL-17) and improved the clinical symptoms. PMID:27602399

  5. The Effect of Photodynamic Therapy and Diode Laser as Adjunctive Periodontal Therapy on the Inflammatory Mediators Levels in Gingival Crevicular Fluid and Clinical Periodontal Status

    Directory of Open Access Journals (Sweden)

    Faraz Teymouri

    2016-09-01

    Full Text Available Statement of the Problem: The presence of bacterial biofilms is the major cause of gingivitis and periodontitis, their mechanical removal is not often enough. Therefore, laser therapy and photodynamic therapy can be effective as adjunctive treatment. Purpose: This study aimed to evaluate the impact of these treatments on the level of gingival crevicular fluid (GCF, inflammatory mediators, and periodontal clinical status. Materials and Method: In this clinical trial, three quadrants were studied in 12 patients with chronic periodontitis aged 30-60 years. The clinical parameters were recorded and GCF samples were taken. After the first phase of periodontal treatment, one of the three quadrants was determined as the control group, one was treated by diode laser, and one underwent photodynamic therapy. The clinical parameters were recorded 2 and 6 weeks later. The data were statistically analyzed by using Friedman, ANOVA, and LSD post-test. Results: Significant reduction was observed over time in the level of Interleukin-1β (IL-1β, Interleukin-17 (IL-17, clinical attachment loss, and pocket depth in the three treatment groups (p< 0.000. The three treatment methods significantly reduced the IL-1β and IL-17 at the baseline, up to 2 weeks, and 2-6 weeks (p< 0.05. Diode laser and photodynamic therapy significantly decreased the average bleeding on probing over time (p< 0.000 and p< 0.002, respectively. Conclusion: Laser and photodynamic therapy reduced the inflammatory mediators (IL-1β and IL-17 and improved the clinical symptoms.

  6. Controllable Acoustic Mixing of Fluids in Microchannels for the Fabrication of Therapeutic Nanoparticles

    Directory of Open Access Journals (Sweden)

    Christoph Westerhausen

    2016-09-01

    Full Text Available Fifteen years ago, surface acoustic waves (SAW were found to be able to drive fluids and numerous applications in microfluidics have been developed since. Here, we review the progress made and report on new approaches in setting-up microfluidic, continuous flow acoustic mixing. In a microchannel, chaotic advection is achieved by generation of a SAW driven fluid jet perpendicular to the mean flow direction. Using a high speed video camera and particle image velocimetry, we measure the flow velocities and show that mixing is achieved in a particularly controllable and fast way. The mixing quality is determined as a function of system parameters: SAW power, volume flux and fluid viscosity. Exploring the parameter space of mixing provides a practical guide for acoustic mixing in microchannels and allows for adopting conditions to different solvents, as e.g., required for the generation of nanoscale particles from alcoholic phases. We exemplarily demonstrate the potential of SAW based continuous flow mixing for the production of therapeutic nucleic acid nanoparticles assembled from polymer and lipid solutions.

  7. Controlling system components with a sound card: A versatile inkjet fluid testing platform.

    Science.gov (United States)

    Bognet, Brice; Guo, Yang; Ma, Anson W K

    2016-01-01

    In this paper, we demonstrate how to use a personal computer sound card to develop an experimental platform for evaluating the jettability and jetting behavior of inkjet fluids. The test fluid is driven out of a nozzle acoustically using a loudspeaker, forming a jet. The subsequent jet breakup process is then captured using a stroboscopic light source and a camera. Instead of using a delay generator as in previous work, the current setup uses a computer sound card and audio amplifier to (i) generate actuation waveforms of arbitrary shapes and (ii) synchronize the jet actuation and imaging with a time precision close to 5 μs. To correct for any signal distortions caused by the built-in high pass filters of the sound card and amplifier, a numerical filter is created and applied before sending the desired signal to the sound card. Such correction method does not require physically modifying the hardware of the sound card or amplifier and is applicable to different waveforms and filters provided that the transfer function is correctly identified. The platform has been tested using 20% (v/v) glycerol in water as a model fluid. Combining this platform with digital image analysis further enables a quantitative assessment of parameters such as the volumes and positions of the jet and drop that are important for quality control and development of new ink formulations.

  8. Controlling system components with a sound card: A versatile inkjet fluid testing platform

    Science.gov (United States)

    Bognet, Brice; Guo, Yang; Ma, Anson W. K.

    2016-01-01

    In this paper, we demonstrate how to use a personal computer sound card to develop an experimental platform for evaluating the jettability and jetting behavior of inkjet fluids. The test fluid is driven out of a nozzle acoustically using a loudspeaker, forming a jet. The subsequent jet breakup process is then captured using a stroboscopic light source and a camera. Instead of using a delay generator as in previous work, the current setup uses a computer sound card and audio amplifier to (i) generate actuation waveforms of arbitrary shapes and (ii) synchronize the jet actuation and imaging with a time precision close to 5 μs. To correct for any signal distortions caused by the built-in high pass filters of the sound card and amplifier, a numerical filter is created and applied before sending the desired signal to the sound card. Such correction method does not require physically modifying the hardware of the sound card or amplifier and is applicable to different waveforms and filters provided that the transfer function is correctly identified. The platform has been tested using 20% (v/v) glycerol in water as a model fluid. Combining this platform with digital image analysis further enables a quantitative assessment of parameters such as the volumes and positions of the jet and drop that are important for quality control and development of new ink formulations.

  9. Cerebrospinal fluid and serum cytokine profiles in narcolepsy with cataplexy: a case-control study.

    Science.gov (United States)

    Dauvilliers, Yves; Jaussent, Isabelle; Lecendreux, Michel; Scholz, Sabine; Bayard, Sophie; Cristol, Jean Paul; Blain, Hubert; Dupuy, Anne-Marie

    2014-03-01

    Recent advances in the identification of susceptibility genes and environmental exposures provide strong support that narcolepsy-cataplexy is an immune-mediated disease. Only few serum cytokine studies with controversial results were performed in narcolepsy and none in the cerebrospinal fluid. We measured a panel of 12 cytokines by a proteomic approach in the serum of 35 patients with narcolepsy-cataplexy compared to 156 healthy controls, and in the cerebrospinal fluid of 34 patients with narcolepsy-cataplexy compared to 17 non-narcoleptic patients; and analyzed the effect of age, duration and severity of disease on the cytokine levels. After multiple adjustments we reported lower serum IL-2, IL-8, TNF-α, MCP-1 and EGF levels, and a tendency for higher IL-4 level in narcolepsy compared to controls. Significant differences were only found for IL-4 in cerebrospinal fluid, being higher in narcolepsy. Positive correlations were found in serum between IL-4, daytime sleepiness, and cataplexy frequency. The expression of some pro-inflammatory cytokines (MCP-1, VEGF, EGF, IL2, IL-1β, IFN-γ) in either serum or CSF was negatively correlated with disease severity and duration. No correlation was found for any specific cytokine in 18 of the patients with narcolepsy with peripheral and central samples collected the same day. Significant decreased pro/anti-inflammatory cytokine profiles were found at peripheral and central levels in narcolepsy, together with a T helper 2/Th1 serum cytokine secretion imbalance. To conclude, we showed some evidence for alterations in the cytokine profile in patients with narcolepsy-cataplexy compared to controls at peripheral and central levels, with the potential role of IL-4 and significant Th1/2 imbalance in the pathophysiology of narcolepsy.

  10. Fluid-controlled tunable infrared filtering in hollow plasmonic nanofin cavities

    Science.gov (United States)

    Ho, Ya-Lun; Abasaki, Minoru; Yin, Shichen; Liu, Xin; Delaunay, Jean-Jacques

    2016-10-01

    Subwavelength structures sustaining surface plasmons have been employed in numerous fields due to their small size and ability to manipulate light beyond the diffraction limit. Light filtering using small-size plasmonic devices is a promising means of portable spectroscopy for purposes such as on-site chemical analyses. However, most plasmonic filters can only tune the resonance band by modifying the geometry of the structure or changing the incident light angle. Here, we present a plasmonic nanofin-cavity structure having a narrow band with its resonance wavelength controlled by varying the fluid in the hollow cavities of the filter. Control of the narrow-band resonance is realized over a wide range because of the coupling between the stationary surface plasmons generated from the nanofin-cavity mode and the propagating surface plasmons. The hollow cavity design enables fluid to be easily injected and removed, so that the filtered band can be controlled without the need for a complex and bulky structure or application of an external voltage.

  11. Fabrication of Multscale Fractal-Like Structures by Controlling Fluid Interface Instability

    Science.gov (United States)

    Islam, Tanveer Ul; Gandhi, Prasanna S.

    2016-11-01

    Nature, in quest for the best designs has shaped its vital systems into fractal geometries. Effectual way of spontaneous fabrication of scalable, ordered fractal-like structures by controlling Saffman-Taylor instability in a lifted Hele-Shaw cell is deployed here. In lifted Hele-Shaw cell uncontrolled penetration of low-viscosity fluid into its high-viscosity counterpart is known to develop irregular, non-repeatable, normally short-lived, branched patterns. We propose and characterize experimentally anisotropies in a form of spatially distributed pits on the cell plates to control initiation and further penetration of non-splitting fingers. The proposed control over shielding mechanism yields recipes for fabrication of families of ordered fractal-like patterns of multiple generations. As an example, we demonstrate and characterize fabrication of a Cayley tree fractal-like pattern. The patterns, in addition, are retained permanently by employing UV/thermally curable fluids. The proposed technique thus establishes solid foundation for bio-mimicking natural structures spanning multiple-scales for scientific and engineering use.

  12. Structural vibration control via electrorheological-fluid-based actuators with adaptive viscous and frictional damping

    Science.gov (United States)

    Wang, K. W.; Kim, Y. S.; Shea, D. B.

    1994-10-01

    It has been recognized that the semi-active control concept is promising for vibration suppression of flexible structures and that the electrorheological (ER) fluid-based device is a good candidate for such applications. In this research, a new control law is developed to maximize the damping effect of ER dampers for structural vibration suppression under actuator constraints and viscous-frictional-combined damping. Numerical simulations and experimental work are carried out to evaluate the semi-active concept. It is illustrated that the performance of the semi-active system is superior to those of the critical damping and maximum damping variety. It is also concluded that the actuator frictional effect is significant, and should be considered in the controller design process.

  13. Large Antenna Control Methods: Current Status and Future Trends

    Science.gov (United States)

    Rodriguez, G.; Lin, Y. H.; Milman, M. H.

    1985-01-01

    Current methods for control of large antennas, as well as future trends required for improved performance are addressed. Some of the target missions in which these methods would be used are: the Land Mobile Satellite System (LMSS) for communications; the Satellite Surveillance (SSS) for aircraft traffic control; the orbiting Very Long Baseline Interferometer (VLBI), or QUASAT, for radio astronomy; and the Large Deployable Reflector (LDR) for IR and submillimeter astronomy.

  14. Status and Future Developments in Large Accelerator Control Systems

    Energy Technology Data Exchange (ETDEWEB)

    Karen S. White

    2006-10-31

    Over the years, accelerator control systems have evolved from small hardwired systems to complex computer controlled systems with many types of graphical user interfaces and electronic data processing. Today's control systems often include multiple software layers, hundreds of distributed processors, and hundreds of thousands of lines of code. While it is clear that the next generation of accelerators will require much bigger control systems, they will also need better systems. Advances in technology will be needed to ensure the network bandwidth and CPU power can provide reasonable update rates and support the requisite timing systems. Beyond the scaling problem, next generation systems face additional challenges due to growing cyber security threats and the likelihood that some degree of remote development and operation will be required. With a large number of components, the need for high reliability increases and commercial solutions can play a key role towards this goal. Future control systems will operate more complex machines and need to present a well integrated, interoperable set of tools with a high degree of automation. Consistency of data presentation and exception handling will contribute to efficient operations. From the development perspective, engineers will need to provide integrated data management in the beginning of the project and build adaptive software components around a central data repository. This will make the system maintainable and ensure consistency throughout the inevitable changes during the machine lifetime. Additionally, such a large project will require professional project management and disciplined use of well-defined engineering processes. Distributed project teams will make the use of standards, formal requirements and design and configuration control vital. Success in building the control system of the future may hinge on how well we integrate commercial components and learn from best practices used in other industries.

  15. Modeling and analysis of controllable output property of cantilever-beam inertial sensors based on magnetic fluid

    Institute of Scientific and Technical Information of China (English)

    Guixiong LIU; Peiqiang ZHANG; Chen XU

    2009-01-01

    Magnetic fluid is first introduced into thetraditional cantileverbeam senor. Based on the property of the cantilever-beam and the novel controllable mag-viscosity of magnetic fluid, the output of cantilever-beam sensors is under control so that the controllable output of the sensors can be realized. The mathematical model of the sensors is established and analyzed. The dynamic control function and the following educational results, which include the two curves of the displacement ratio and phase function with the different damping ratio and frequency ratio, are obtained based on the model. The result shows that it is valid to realize the controllable output of the sensors by controlling the viscosity of the magnetic fluid,and finally the expanded measurement range can be realized.

  16. The Controls Middleware (CMW) at CERN Status and Usage

    CERN Document Server

    Andersson, J; Kostro, K; Di Maio, F; Trofimov, N

    2003-01-01

    A new Controls Middleware (CMW) for the "LHC era" has been recently designed and imp lemented to serve the CERN accelerator sector. It has now been used for almost two years in the operation of the PS accelerator complex and is being introduced for the control of all the upcoming LHC equipment as well as for the existing SPS equipment. This paper presents the architecture and capabilities of the system and shows how it has been integrated in the existing controls environment. The use of publish/subscribe paradigm, the performance of the system, and administration facilities are described as well. Based on the experience with CMW we also discuss the validity of choices, which were made almost four years ago.

  17. Development of a Mechatronic Syringe Pump to Control Fluid Flow in a Microfluidic Device Based on Polyimide Film

    Science.gov (United States)

    Sek Tee, Kian; Sharil Saripan, Muhammad; Yap, Hiung Yin; Fhong Soon, Chin

    2017-08-01

    With the advancement in microfluidic technology, fluid flow control for syringe pump is always essential. In this paper, a mechatronic syringe pump will be developed and customized to control the fluid flow in a poly-dimethylsiloxane (PDMS) microfluidic device based on a polyimide laminating film. The syringe pump is designed to drive fluid with flow rates of 100 and 1000 μl/min which intended to drive continuous fluid in a polyimide based microfluidic device. The electronic system consists of an Arduino microcontroller board and a uni-polar stepper motor. In the system, the uni-polar stepper motor was coupled to a linear slider attached to the plunger of a syringe pump. As the motor rotates, the plunger pumps the liquid out of the syringe. The accuracy of the fluid flow rate was determined by adjusting the number of micro-step/revolution to drive the stepper motor to infuse fluid into the microfluidic device. With the precise control of the electronic system, the syringe pump could accurately inject fluid volume at 100 and 1000 μl/min into a microfluidic device.

  18. Some Factors Controlling the Seismic Hazard due to Earthquakes Induced by Fluid Injection at Depth

    Science.gov (United States)

    McGarr, A.

    2012-12-01

    The maximum seismic moment (or moment magnitude) is an important measure of the seismic hazard associated with earthquakes induced by deep fluid injection. Although it would be advantageous to be able to predict the induced earthquake outcome, including the maximum seismic moment, of a specified fluid injection project in advance, this capability has, to date, proved to be elusive because the geomechanical and hydrological factors that control the seismic response to injection are too poorly understood. Fortunately, the vast majority of activities involving the injection of fluids into deep aquifers do not cause earthquakes that are large enough to be of any consequence. There have been, however, significant exceptions during the past 50 years, starting with the earthquakes induced by injection of wastewater at the Rocky Mountain Arsenal Well, during the 1960s, that caused extensive damage in the Denver, CO, area. Results from numerous case histories of earthquakes induced by injection activities, including wastewater disposal at depth and the development of enhanced geothermal systems, suggest that it may be feasible to estimate bounds on maximum magnitudes based on the volume of injected liquid. For these cases, volumes of injected liquid ranged from approximately 11.5 thousand to 5 million cubic meters and resulted in main shock moment magnitudes from 3.4 to 5.3. Because the maximum seismic moment appears to be linearly proportional to the total volume of injected fluid, this upper bound is expected to increase with time as long as a given injection well remains active. For example, in the Raton Basin, southern Colorado and northern New Mexico, natural gas is produced from an extensive coal bed methane field. The deep injection of wastewater associated with this gas production has induced a sequence of earthquakes starting in August 2001, shortly after the beginning of major injection activities. Most of this seismicity defines a northeast striking plane dipping

  19. Organizational control and the status of marketing in multihospital systems.

    Science.gov (United States)

    Tucker, L R; Zaremba, R A

    1991-01-01

    Research on organizational control and multihospital systems has focused on operational and performance characteristics. Little attention has been directed to the role of marketing as an operational strategy. This article examines the practice of marketing across interorganizational types and develops comparative profiles.

  20. Surface Patterning: Controlling Fluid Flow Through Dolphin and Shark Skin Biomimicry

    Science.gov (United States)

    Gamble, Lawren; Lang, Amy; Bradshaw, Michael; McVay, Eric

    2013-11-01

    Dolphin skin is characterized by circumferential ridges, perpendicular to fluid flow, present from the crest of the head until the tail fluke. When observing a cross section of skin, the ridges have a sinusoidal pattern. Sinusoidal grooves have been proven to induce vortices in the cavities that can help control flow separation which can reduce pressure drag. Shark skin, however, is patterned with flexible scales that bristle up to 50 degrees with reversed flow. Both dolphin ridges and shark scales are thought to help control fluid flow and increase swimming efficiency by delaying the separation of the boundary layer. This study investigates how flow characteristics can be altered with bio-inspired surface patterning. A NACA 4412 hydrofoil was entirely patterned with transverse sinusoidal grooves, inspired by dolphin skin but scaled so the cavities on the model have the same Reynolds number as the cavities on a swimming shark. Static tests were conducted at a Reynolds number of approximately 100,000 and at varying angles of attack. The results were compared to the smooth hydrofoil case. The flow data was quantified using Digital Particle Image Velocimetry (DPIV). The results of this study demonstrated that the patterned hydrofoil experienced greater separation than the smooth hydrofoil. It is hypothesize that this could be remediated if the pattern was placed only after the maximum thickness of the hydrofoil. Funding through NSF REU grant 1062611 is gratefully acknowledged.

  1. Investigation and Comparison Effects of Fluid Injection Type in Thrust Vector Control

    Directory of Open Access Journals (Sweden)

    M.R Heidari

    2016-01-01

    Full Text Available In this research, the effects of some liquid side injection from nozzle wall into exhaust gas of combustion chamber are studied. The side injection against main flow is as elliptical solid thing that change the symmetric of flow field on nozzle wall and causes some different pressure distribution on wall, and finally causes thrust vector deviation. Flows interaction causes some physical phenomena as bow shock wave in front of injection region. This paper explain the effects of this wave and variation velocity & pressure distribution at different cross sections of flow field and comparison results of air and other liquid fluid in thrust vector control system. The results are compared with experimental data and have well agreement with them. The results show that Freon is one of best injection liquid for this type of thrust vector control. Performance of Injection is optimum in relative position 35 to 40% nozzle divergence length.

  2. Modeling of fluid-induced vibrations and identification of hydrodynamic forces on flow control valves

    Institute of Scientific and Technical Information of China (English)

    Samad Mehrzad; Ilgar Javanshir; Ahmad Rahbar Ranji; Seyyed Hadi Taheri

    2015-01-01

    Dynamics and vibration of control valves under flow-induced vibration are analyzed. Hydrodynamic load characteristics and structural response under flow-induced vibration are mainly influenced by inertia, damping, elastic, geometric characteristics and hydraulic parameters. The purpose of this work is to investigate the dynamic behavior of control valves in the response to self-excited fluid flow. An analytical and numerical method is developed to simulate the dynamic and vibrational behavior of sliding dam valves, in response to flow excitation. In order to demonstrate the effectiveness of proposed model, the simulation results are validated with experimental ones. Finally, to achieve the optimal valve geometry, numerical results for various shapes of valves are compared. Rounded valve with the least amount of flow turbulence obtains lower fluctuations and vibration amplitude compared with the flat and steep valves. Simulation results demonstrate that with the optimal design requirements of valves, vibration amplitude can be reduced by an average to 30%.

  3. Enhanced versatility of fluid control in centrifugal microfluidic platforms using two degrees of freedom.

    Science.gov (United States)

    Cao, Xiaobao; deMello, A J; Elvira, K S

    2016-04-01

    Centrifugal microfluidic platforms have significant potential in commercial applications because of their operational flexibility and minimal external infrastructure requirements. However, the dynamic and real-time control of fluid flow within traditional centrifugal microfluidic platforms is problematic. To address this significant limitation, we propose a two degrees of freedom platform, in which a digital servo is located at each end of an arm driven by a motor. This allows for reversible inward pumping between multiple chambers with perfect efficiency. Furthermore, the addition of a second degree of freedom allows position-based pressure controlled burst valves to be accessed and operated in an independent fashion. To demonstrate the efficacy of this technical innovation, we show rapid and configurable flow switching between three target chambers within a centrifugal microfluidic device.

  4. VLT telescope control software: status, development, and lessons learned

    Science.gov (United States)

    Wirenstrand, Krister

    2003-02-01

    The four 8m VLT telescopes on Paranal are now in full science operation, and they all deliver good results with very small technical downtimes. Of course, many factors are contributing to these results, and also the telescope control software has its share. It has demonstrated to be robust and reliable and also flexible and expandable. In the four years since First Light of the first VLT telescope, this software has been continuously maintained and developed, for improvements on the 8m telescopes but also for use on other telescopes. In addition to the 8m ones, another three telescopes, using applicable parts of the same software, are in operation on Paranal: the 350- mm seeing monitor and two 400-mm siderostats. And the process continues: in the beginning of 2003 the first of three 1.8m Auxiliary Telescopes for the VLT Interferometer will be installed; the control software to 80% being the same as for the 8m telescopes, but with additional devices and control functionality. Another three ESO telescopes on La Silla are also using the same software, as well as two wide field telescopes for Paranal that are now in the design and manufacturing phase. In this development process, and in particular after first installation, we have learned lessons in many areas of software project work. System design and engineering, standardization, tools, testing: these are example areas where there is always room for improvement. Another lesson learned is the importance of the concept of Commissioning, i.e. the work to take the telescope from "integrated" to "working"! What the future of telescope control software will be, that we don't know, but we are working on it! And we try to keep an evolutionary approach, taking advantage of the lessons learned.

  5. Zinc status in febrile seizure: a case-control study.

    Science.gov (United States)

    Salehiomran, Mohammad Reza; Mahzari, Masoumeh

    2013-01-01

    Febrile seizure is the most common type of seizure in children. Their incidence is 2-5%. There are different hypotheses about relationship between neurotransmitters and trace elements (such as zinc) and febrile seizure. Zinc, as a major element of some enzymes, plays an important role in the central nervous system (CNS) and can affect some inhibitory mechanisms of CNS. The aim of the present study was to determine whether there were any changes in serum zinc level in children with febrile seizure in comparison with febrile children without seizure. This case-control study was performed on 100 patients aged 6 months to 6 years. This study was conducted between January and August 2012, on 50 children with febrile seizures (case) and 50 febrile children without seizures (control), that were referred to Amirkola Children Hospital (a referral hospital in the north of Iran). Two groups were matched for age and sex. The serum zinc levels in the both groups were determined by atomic absorption spectrophotometry method. The mean serum zinc level was 0.585±0.166 mg/L and 0.704±0.179 mg/L in the case group and the control group, respectively (p=0.001). The mean serum zinc level was significantly lower in the febrile seizure group compared to the control groups. Our findings revealed that serum zinc level was significantly lower in children with simple febrile seizure in comparison with febrile children without seizure. It can emphasize the hypothesis that there is a relation between serum zinc level and febrile seizure in children.

  6. Current status and control of rabies in Perú

    OpenAIRE

    2007-01-01

    Rabies is an endemic disease of Peru, that appears in two cycles, one urban related with transmission by dog, and another wild caused mainly by vampires bats bite. Most of human cases of the last decades they have been by urban rabies, nevertheless the used measures of control (canine vaccine campaigns, vaccine production, identification of biting dog, opportune attention of the victim and surveillance and notification system) they have managed to reduce the incidence of canine rabies and ...

  7. Current status of hypertension control around the world.

    Science.gov (United States)

    Erdine, Serap; Aran, Sinan Nazif

    2004-01-01

    It is well established that hypertension is an important risk factor for cardiovascular disease. Data from epidemiological and observational studies have demonstrated increasing risk of stroke, myocardial infarction, cardiovascular death and all cause mortality associated with high blood pressure. Despite the significance of the problem with respect to overall health, control of high blood pressure is far from being optimal. Data from the National Health and Nutrition Survey have shown that those achieving target blood pressure values less than 140/90 mmHg are only 34% of the hypertensive population. The situation is no better in the rest of the world and even worse in the developing countries. Epidemiological transition taking place in developing countries with a decline in communicable diseases and an increase in noncommunicable have resulted in an improvement in life expectancy, thus causing predictable shifts in causes of death. Aging of the populations, urbanization and socioeconomic changes in the developing world have led to an increase in the prevalence of hypertension, with low control rates due to scarce health resources and insufficient health infrastructure. Thus prevention, detection, treatment and control of hypertension play a crucial role in protection of cardiovascular disease, not only in the developed countries but also in the developing world and implementation of hypertension guidelines should be reinforced around the world.

  8. Current Status of Parasite Control at the Feed Yard.

    Science.gov (United States)

    Yazwinski, Thomas A; Tucker, Chris A; Powell, Jeremy; Beck, Paul; Wray, Eva; Weingartz, Christine

    2015-07-01

    Fly and louse infestations are readily discerned and remedied in feedlot cattle. Tapeworm and fluke infections are accepted as probable but, given the lack of anthelmintics with realistic efficacy against these infections, these helminths are allowed to persist without treatment. Nematode infections are considered ubiquitous with cattle coming from pasture and are targeted with a macrocyclic lactone, usually in combination with a benzimidazole. Populations of nematodes seem to be effectively controlled by a combination of anthelmintic treatment, animal resistance and resilience, lack of reinfection, and diet.

  9. Amniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study

    Directory of Open Access Journals (Sweden)

    M. Erdemoğlu

    2011-07-01

    Full Text Available In a prospective case-control study, we compared the amniotic fluid amino acid levels in non-immune hydrops fetalis (NIHF and normal fetuses. Eighty fetuses underwent amniocentesis for different reasons at the prenatal diagnosis unit of the Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University. Forty of these fetuses were diagnosed with NIHF. The study included 40 women each in the NIHF (mean age: 27.69 ± 4.56 years and control (27.52 ± 5.49 years groups, who had abnormal double- or triple-screening test values with normal fetuses with gestational ages of 23.26 ± 1.98 and 23.68 ± 1.49 weeks at the time of sample collection, respectively. Amniotic fluid amino acid concentrations (intra-assay variation: 2.26-7.85%; interassay variation: 3.45-8.22% were measured using EZ:faast kits (EZ:faast GC/FID free (physiological amino acid kit; Phenomenex, USA by gas chromatography. The standard for quantitation was a mixture of free amino acids from Phenomenex. The levels of 21 amino acids were measured. The mean phosphoserine and serine levels were significantly lower in the NIHF group, while the taurine, α-aminoadipic acid (aaa, glycine, cysteine, NH4, and arginine (Arg levels were significantly higher compared to control. Significant risk variables for the NIHF group and odds coefficients were obtained using a binary logistic regression method. The respective odds ratios and 95% confidence intervals for the risk variables phosphoserine, taurine, aaa, Arg, and NH4 were 3.31 (1.84-5.97, 2.45 (1.56-3.86, 1.78 (1.18-2.68, 2.18 (1.56-3.04, and 2.41 (1.66-3.49, respectively. The significant difference between NIHF and control fetuses suggests that the amniotic fluid levels of some amino acids may be useful for the diagnosis of NIHF.

  10. National Ignition Facility Project Completion and Control System Status

    Energy Technology Data Exchange (ETDEWEB)

    Van Arsdall, P J; Azevedo, S G; Beeler, R G; Bryant, R M; Carey, R W; Demaret, R D; Fisher, J M; Frazier, T M; Lagin, L J; Ludwigsen, A P; Marshall, C D; Mathisen, D G; Reed, R K

    2009-10-02

    The National Ignition Facility (NIF) is the world's largest and most energetic laser experimental system providing a scientific center to study inertial confinement fusion (ICF) and matter at extreme energy densities and pressures. Completed in 2009, NIF is a stadium-sized facility containing a 1.8-MJ, 500-TW 192-beam ultraviolet laser and target chamber. A cryogenic tritium target system and suite of optical, X-ray and nuclear diagnostics will support experiments in a strategy to achieve fusion ignition starting in 2010. Automatic control of NIF is performed by the large-scale Integrated Computer Control System (ICCS), which is implemented by 2 MSLOC of Java and Ada running on 1300 front-end processors and servers. The ICCS framework uses CORBA distribution for interoperation between heterogeneous languages and computers. Laser setup is guided by a physics model and shots are coordinated by data-driven distributed workflow engines. The NIF information system includes operational tools and a peta-scale repository for provisioning experimental results. This paper discusses results achieved and the effort now underway to conduct full-scale operations and prepare for ignition.

  11. Bioadhesive emulsions for control release of progesterone resistant to vaginal fluids clearance.

    Science.gov (United States)

    Campaña-Seoane, Maria; Peleteiro, Aaron; Laguna, Reyes; Otero-Espinar, Francisco J

    2014-12-30

    The aim of this study is to propose that mucoadhesive vaginal emulsions can be able to resist the clearance effect of vaginal fluid and to have an effective control release of progesterone. With this goal, silicon derivative, cyclomethicone pentamer, was selected as the bioadhesive and water resistant material. In order to obtain a system which is insensitive to the dilution of aqueous fluids, water in silicone (W/S) emulsions were prepared and different proportions of cyclomethicone as well as 8% or 15% w/w of progesterone were employed. The rheological, mechanical and mucoadhesive properties of emulsions were characterized and the drug release was measured for each formulation. Mucoadhesive behavior was determined and the influence of simulated vaginal fluid (SVF) at bioadhesion was assessed using three commercial mucoadhesive vaginal gels (Crinone(®), K-Y jelly(®) and Zidoval(®)) as the bioadhesive references. All assayed emulsions have good rheological and mechanical properties and their consistence and viscosity increase when the proportion of the internal phase increases. Related to mucoadhesion, in the absence of SVF, W/S emulsions showed similar bioadhesive levels like the commercial formulations. However, in the presence of SVF, W/S emulsions are able to keep their mucoadhesive properties while the marketed references drastically lose their consistency and adherence to the vaginal mucosa. Drug release profiles from W/S emulsion show that progesterone is released with pseudo-order zero kinetics and a constant release rate is maintained for at least two weeks. The results of the in vivo studies developed in rats show that after a single vaginal administration, bioadhesive W/S emulsions increase the uterine tissue progesterone levels in young and postmenopausal rats. Moreover in postmenopausal rats, they provide high uterine levels of progesterone compared to the bioadhesive-marketed gel used as a reference. Therefore, W/S emulsions have an interesting

  12. Flow Diode and Method for Controlling Fluid Flow Origin of the Invention

    Science.gov (United States)

    Dyson, Rodger W (Inventor)

    2015-01-01

    A flow diode configured to permit fluid flow in a first direction while preventing fluid flow in a second direction opposite the first direction is disclosed. The flow diode prevents fluid flow without use of mechanical closures or moving parts. The flow diode utilizes a bypass flowline whereby all fluid flow in the second direction moves into the bypass flowline having a plurality of tortuous portions providing high fluidic resistance. The portions decrease in diameter such that debris in the fluid is trapped. As fluid only travels in one direction through the portions, the debris remains trapped in the portions.

  13. A semi-active control suspension system for railway vehicles with magnetorheological fluid dampers

    Science.gov (United States)

    Wei, Xiukun; Zhu, Ming; Jia, Limin

    2016-07-01

    The high-speed train has achieved great progress in the last decades. It is one of the most important modes of transportation between cities. With the rapid development of the high-speed train, its safety issue is paid much more attention than ever before. To improve the stability of the vehicle with high speed, extra dampers (i.e. anti-hunting damper) are used in the traditional bogies with passive suspension system. However, the curving performance of the vehicle is undermined due to the extra lateral force generated by the dampers. The active suspension systems proposed in the last decades attempt to solve the vehicle steering issue. However, the active suspension systems need extra actuators driven by electrical power or hydraulic power. There are some implementation and even safety issues which are not easy to be overcome. In this paper, an innovative semi-active controlled lateral suspension system for railway vehicles is proposed. Four magnetorheological fluid dampers are fixed to the primary suspension system of each bogie. They are controlled by online controllers for enhancing the running stability on the straight track line on the one hand and further improving the curving performance by controlling the damper force on the other hand. Two control strategies are proposed in the light of the pure rolling concept. The effectiveness of the proposed strategies is demonstrated by SIMPACK and Matlab co-simulation for a full railway vehicle with two conventional bogies.

  14. Granule size control and targeting in pulsed spray fluid bed granulation.

    Science.gov (United States)

    Ehlers, Henrik; Liu, Anchang; Räikkönen, Heikki; Hatara, Juha; Antikainen, Osmo; Airaksinen, Sari; Heinämäki, Jyrki; Lou, Honxiang; Yliruusi, Jouko

    2009-07-30

    The primary aim of the study was to investigate the effects of pulsed liquid feed on granule size. The secondary aim was to increase knowledge of this technique in granule size targeting. Pulsed liquid feed refers to the pump changing between on- and off-positions in sequences, called duty cycles. One duty cycle consists of one on- and off-period. The study was performed with a laboratory-scale top-spray fluid bed granulator with duty cycle length and atomization pressure as studied variables. The liquid feed rate, amount and inlet air temperature were constant. The granules were small, indicating that the powder has only undergone ordered mixing, nucleation and early growth. The effect of atomizing pressure on granule size depends on inlet air relative humidity, with premature binder evaporation as a reason. The duty cycle length was of critical importance to the end product attributes, by defining the extent of intermittent drying and rewetting. By varying only the duty cycle length, it was possible to control granule nucleation and growth, with a wider granule size target range in increased relative humidity. The present study confirms that pulsed liquid feed in fluid bed granulation is a useful tool in end product particle size targeting.

  15. Status quo of applications of new control theories for hydraulic control systems; Shinseigyo riron no yuatsu eno oyo no genjo

    Energy Technology Data Exchange (ETDEWEB)

    Yokota, S. [Tokyo Institute of Technology, Tokyo (Japan)

    2000-05-15

    This paper describes application of a new control theory to hydraulics. The modern control theory has become applied to hydraulics since about the 1940's, and optimal polarity arrangement by using the status feedback and adaptive control represented by MRAC have emerged. Thereafter, the robust control comes on stage as a fusion of the status space method and the frequency zone theory. For the application thereof, much discussions were given on adaptive control represented by MRAC in order to cover large variation in system parameters in hydraulic control. Since variable parameters are included, there are problems of identification of safety limit, and time delay. Fuzzy control allowing the mathematical model of the subject system to be unclear and neural net control are expanding their applications because of their easiness of handling. The robust control has also begun being applied partly, which is regarded useful for servos. Design freedom is high because target followability and stability are designed separately. However, reliable introduction of two-freedom degree control system such as H{sub {infinity}} control is indispensable. The paper also describes the single adaptive control (SAC) and the sliding mode control (SMC). (NEDO)

  16. Status of the advanced photon source and its accelerator control system

    Science.gov (United States)

    McDowell, W.; Knott, M.; Kraimer, M.

    1994-12-01

    This paper presents the current status of the Advanced Photon Source (APS), its control system and the Experimental Physics and Industrial Control System (EPICS) tools being used to implement this control system. The status of the physical plant and each of the accelerators as well as detailed descriptions of the software tools used to build the accelerator control system are presented. The control system uses high-performance graphic workstations and the X-Windows graphical user interface (GUI) at the operator interface level. It connects to VME/VXI-based microprocessors at the field level, using TCP/IP protocols over high-performance networks. This strategy assures the flexibility and expansibility of the control system. A defined interface between the system components will allow the system to evolve with the direct addition of future, improved equipment and new capabilities.

  17. Brittle versus ductile deformation as the main control of the deep fluid circulation in continental crust

    Science.gov (United States)

    Violay, Marie; Madonna, Claudio; Burg, Jean-Pierre

    2016-04-01

    The Japan Beyond-Brittle Project (JBBP) and the Taupo Volcanic Zone-Deep geothermal drilling project in New Zealand (TVZ-DGDP) proposed a new concept of engineered geothermal development where reservoirs are created in ductile rocks. This system has several advantages including (1) a simpler design and control of the reservoir due to homogeneous rock properties and stress states in the ductile domain ,(2) possible extraction of supercritical fluids (3) less probability for induced earthquakes. However, it is at present unknwon what and how porosity and permeability can be engineered in such environments. It has been proposed that the magmatic chamber is surrounded by a hot and ductile carapace through which heat transfer is conductive because the plastic behaviour of the rock will close possible fluid pathways. Further outward, as temperature declines, the rock will encounter the brittle-ductile transition with a concomitant increase in porosity and permeability. The thickness of the conduction-dominated, ductile boundary zone between the magmatic chamber and the convecting geothermal fluid directly determines the rate of heat transfer. To examine the brittle to ductile transition in the context of the Japanese crust, we conducted deformation experiments on very-fine-grain granite in conventional servocontrolled, gas-medium triaxial apparatus (from Paterson instrument). Temperature ranged from 600° C to 1100° C and effective confining pressure from 100 to 150 MPa. Dilatancy was measured during deformation. The method consisted in monitoring the volume of pore fluid that flows into or out of the sample at constant pore pressure. Permeability was measured under static conditions by transient pressure pulse method. Mechanical and micro-structural observations at experimental constant strain rate of 10-5 s-1 indicated that the granite was brittle and dilatant up to 900 ° C. At higher temperatures the deformation mode becomes macroscopically ductile, i

  18. Warming Intravenous Fluids for Improved Patient Comfort in the Emergency Department: A Pilot Crossover Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Wesley H Self

    2013-09-01

    Full Text Available Introduction: The purpose of this study was to test if intravenous (IV fluids warmed to body temperature are associated with greater patient comfort than room temperature IV fluids in adult emergency department (ED patients.Methods: This was a pilot double-blind, crossover, randomized controlled trial. Enrolled subjects sequentially received boluses of body temperature (36ºC and room temperature (22 ºC IV fluid, with the order of boluses randomized. Each subject’s level of discomfort was assessed prior to and after each bolus, using a 10 cm visual analog scale (Discomfort VAS, with higher scores indicating greater discomfort. We calculated the change in Discomfort VAS score associated with body temperature IV fluid (ΔVASbody and room temperature IV fluid (ΔVASroom by subtracting the score reported before the bolus from the score reported after that bolus. We compared changes in Discomfort VAS score with body temperature and room temperature IV fluid using the Wilcoxon matched-pairs signed-rank test.Results: Twenty-seven subjects were included. Treatment with body temperature IV fluid was associated with a significant decrease in discomfort (median ΔVASbody: -0.7 cm; interquartile range (IQR: -4.5 cm to +0.4 cm compared to room temperature IV fluid (median ΔVASroom: +1.2 cm; interquartile range: -0.1 cm to + 3.6 cm (P = 0.001.Conclusion: In this small trial of adult ED patients, infusing IV fluids warmed to body temperature was associated with improved comfort compared to standard, room temperature IV fluids. [West J Emerg Med. 2013;14(5:542–546.

  19. Control server for the PS orbit acquisition system Status 2009

    CERN Document Server

    Bart-Pedersen, S; CERN. Geneva. BE Department

    2009-01-01

    CERN’s Proton Synchrotron (CPS) has been fitted with a new Trajectory Measurement System (TMS). Analogue signals from forty Beam Position Monitors (BPM) are digitized at 125 MS/s, and then further treated in the digital domain to derive positions of all individual particle bunches on the fly. Large FPGAs are used to handle the digital processing. The system fits in fourteen plug-in modules distributed over three half-width cPCI crates that store data in circular buffers. They are connected to a Linux computer by means of a private Gigabit Ethernet segment. Dedicated server software, running under Linux, knits the system into a coherent whole [1]. The corresponding low-level software using FESA (BPMOPS class) was implemented while respecting the standard interface for beam position measurements. The BPMOPS server publishes values on request after data extraction and conversion from the TMS server. This software is running on a VME Lynx-OS platform and through dedicated electronics it can therefore control th...

  20. Relationships among Subjective Social Status, Weight Perception, Weight Control Behaviors, and Weight Status in Adolescents: Findings from the 2009 Korea Youth Risk Behaviors Web-Based Survey

    Science.gov (United States)

    Ha, Yeongmi; Choi, Eunsook; Seo, Yeongmi; Kim, Tae-gu

    2013-01-01

    Background: This study identified relationships among subjective social status (SSS), weight perception, weight control behaviors, and weight status in Korean adolescents using nationally representative data collected from the 2009 Korea Youth Risk Behaviors Web-Based Survey. Methods: Data from 67,185 students aged 12-18 years were analyzed.…

  1. Relationships among Subjective Social Status, Weight Perception, Weight Control Behaviors, and Weight Status in Adolescents: Findings from the 2009 Korea Youth Risk Behaviors Web-Based Survey

    Science.gov (United States)

    Ha, Yeongmi; Choi, Eunsook; Seo, Yeongmi; Kim, Tae-gu

    2013-01-01

    Background: This study identified relationships among subjective social status (SSS), weight perception, weight control behaviors, and weight status in Korean adolescents using nationally representative data collected from the 2009 Korea Youth Risk Behaviors Web-Based Survey. Methods: Data from 67,185 students aged 12-18 years were analyzed.…

  2. Internal Thermal Control System Hose Heat Transfer Fluid Thermal Expansion Evaluation Test Report

    Science.gov (United States)

    Wieland, P. O.; Hawk, H. D.

    2001-01-01

    During assembly of the International Space Station, the Internal Thermal Control Systems in adjacent modules are connected by jumper hoses referred to as integrated hose assemblies (IHAs). A test of an IHA has been performed at the Marshall Space Flight Center to determine whether the pressure in an IHA filled with heat transfer fluid would exceed the maximum design pressure when subjected to elevated temperatures (up to 60 C (140 F)) that may be experienced during storage or transportation. The results of the test show that the pressure in the IHA remains below 227 kPa (33 psia) (well below the 689 kPa (100 psia) maximum design pressure) even at a temperature of 71 C (160 F), with no indication of leakage or damage to the hose. Therefore, based on the results of this test, the IHA can safely be filled with coolant prior to launch. The test and results are documented in this Technical Memorandum.

  3. STUDY ON ELECTRORHEOLOGICAL FLUID DAMPER FOR APPLICATION IN MACHINING CHATTER CONTROL

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The electrorheological fluid(ERF)is a kind of intelligent material with bright prospects for industry applications, which has viscoelastic characteristic under the applied electric field. The dynamic model of a milling system with an ERF damper is established, and the chatter suppression mechanism of the ER effect is discussed theoretically. Both the theoretical study and the experimental investigation show that the additional damping and additional stiffness produced by the ERF increase with the rise in the strength of electric field E, but their influence on the cutting stability is different. Only when both additional damping and additional stiffness cooperate, the milling chatter can be suppressed quickly and effectively. In additional, an ERF damper used on the arbor of horizontal spindle milling machine is developed, and a series of milling chatter control experiments are performed. The experimental results show that the milling chatter can be suppressed effectively by using the ER damper.

  4. Status of the TOUGH-FLAC simulator and recent applications related to coupled fluid flow and crustal deformations

    Energy Technology Data Exchange (ETDEWEB)

    Rutqvist, J.

    2010-06-01

    This paper presents recent advancement in and applications of TOUGH-FLAC, a simulator for multiphase fluid flow and geomechanics. The TOUGH-FLAC simulator links the TOUGH family multiphase fluid and heat transport codes with the commercial FLAC{sup 3D} geomechanical simulator. The most significant new TOUGH-FLAC development in the past few years is a revised architecture, enabling a more rigorous and tight coupling procedure with improved computational efficiency. The applications presented in this paper are related to modeling of crustal deformations caused by deep underground fluid movements and pressure changes as a result of both industrial activities (the In Salah CO{sub 2} Storage Project and the Geysers Geothermal Field) and natural events (the 1960s Matsushiro Earthquake Swarm). Finally, the paper provides some perspectives on the future of TOUGH-FLAC in light of its applicability to practical problems and the need for high-performance computing capabilities for field-scale problems, such as industrial-scale CO{sub 2} storage and enhanced geothermal systems. It is concluded that despite some limitations to fully adapting a commercial code such as FLAC{sup 3D} for some specialized research and computational needs, TOUGH-FLAC is likely to remain a pragmatic simulation approach, with an increasing number of users in both academia and industry.

  5. Status of the TOUGH-FLAC simulator and recent applications related to coupled fluid flow and crustal deformations

    Science.gov (United States)

    Rutqvist, Jonny

    2011-06-01

    This paper presents recent advancement in and applications of TOUGH-FLAC, a simulator for multiphase fluid flow and geomechanics. The TOUGH-FLAC simulator links the TOUGH family multiphase fluid and heat transport codes with the commercial FLAC 3D geomechanical simulator. The most significant new TOUGH-FLAC development in the past few years is a revised architecture, enabling a more rigorous and tight coupling procedure with improved computational efficiency. The applications presented in this paper are related to modeling of crustal deformations caused by deep underground fluid movements and pressure changes as a result of both industrial activities (the In Salah CO 2 Storage Project and the Geysers Geothermal Field) and natural events (the 1960s Matsushiro Earthquake Swarm). Finally, the paper provides some perspectives on the future of TOUGH-FLAC in light of its applicability to practical problems and the need for high-performance computing capabilities for field-scale problems, such as industrial-scale CO 2 storage and enhanced geothermal systems. It is concluded that despite some limitations to fully adapting a commercial code such as FLAC 3D for some specialized research and computational needs, TOUGH-FLAC is likely to remain a pragmatic simulation approach, with an increasing number of users in both academia and industry.

  6. Development of Small-sized Fluid Control Valve with Self-holding Function Using Permanent Magnet

    Science.gov (United States)

    Akagi, Tetsuya; Dohta, Shujiro; Ueda, Hirofumi

    Recently, force feedback devices in virtual reality and power assisted nursing care systems have received much attention and active research. In such a control system, an actuator and a driving device such as a control valve are mounted on the human body. In this condition, the size and weight of the control valve become serious problems. At the same time, the valve should be operated with lower energy consumption because of using a limited electrical power. The typical electro magnetic solenoid valve drives its spool using a larger solenoid to open the valve. The complex construction of the valve for sealing makes its miniaturization and the fabrication of a low cost valve more difficult. In addition, the solenoid in the valve consumes more electrical power while the valve is kept opening. The purpose of our study is to develop a small-sized, lightweight, lower energy consumption and flexible control valve that can be safe enough to mount on the human body at a lower cost. In our pervious study, we proposed and tested the control valve that can open using a vibration motor. In this study, we propose and test a new type of fluid control valve with a self-holding function. The new valve uses a permanent magnet ball. It has a cylindrical magnet and two solenoids. The self-holding function of the valve is done as follows. When one side of the solenoid is stimulated by the current momentarily, the solenoid gives a repulsive force to the cylindrical magnet. The magnet moves toward the opposite side of the solenoid and is attracted to the iron core. Then, the magnet ball moves toward the cylindrical magnet and opens the orifice. The valve can keep open without electrical energy. As a result, the valve with the extremely lower energy consumption can be developed.

  7. Fast Responsive and Controllable Liquid Transport on a Magnetic Fluid/Nanoarray Composite Interface.

    Science.gov (United States)

    Tian, Dongliang; Zhang, Na; Zheng, Xi; Hou, Guanglei; Tian, Ye; Du, Yi; Jiang, Lei; Dou, Shi Xue

    2016-06-28

    Controllable liquid transport on surface is expected to occur by manipulating the gradient of surface tension/Laplace pressure and external stimuli, which has been intensively studied on solid or liquid interface. However, it still faces challenges of slow response rate, and uncontrollable transport speed and direction. Here, we demonstrate fast responsive and controllable liquid transport on a smart magnetic fluid/nanoarray interface, i.e., a composite interface, via modulation of an external magnetic field. The wettability of the composite interface to water instantaneously responds to gradient magnetic field due to the magnetically driven composite interface gradient roughness transition that takes place within a millisecond, which is at least 1 order of magnitude faster than that of other responsive surfaces. A water droplet can follow the motion of the gradient composite interface structure as it responds to the gradient magnetic field motion. Moreover, the water droplet transport direction can be controlled by modulating the motion direction of the gradient magnetic field. The composite interface can be used as a pump for the transport of immiscible liquids and other objects in the microchannel, which suggests a way to design smart interface materials and microfluidic devices.

  8. Life-style modification for weight control to improve diabetes health status.

    Science.gov (United States)

    Wierenga, M E

    1994-04-01

    The purpose of this study was to describe the relationship among variables which are associated with life-style modification, knowledge of diabetes, social support, health practices, and body mass index, to examine their effect on health status, and to test the effectiveness of a community based life-style modification program for weight control. Adults (n = 66) with non-insulin-dependent diabetes mellitus participated in either a treatment or control group. The treatment consisted of 5 weekly 90-min sessions on modifying eating and exercise patterns. All participants completed a personal resource questionnaire (PRQ), health practices survey (HPS), and diabetes health status questionnaire (DHS) at intake, 5 weeks, and 4 months. Knowledge of diabetes was assessed only at intake. Knowledge of diabetes, social support, and health practices explained 27% of the variance in health status, but health practices explained the largest (18%) proportion of the variance and was the only study variable significantly affected by the life-style modification program.

  9. Fracturing fluid cleanup by controlled release of enzymes from polyelectrolyte complex nanoparticles

    Science.gov (United States)

    Barati Ghahfarokhi, Reza

    activity of enzymes by entrapping them. It was also observed that control PEC nanoparticles decreased both viscoelastic moduli, but with a slower rate compared to the PEC nanoparticles loaded with enzyme. Preparation shear and applied shear showed no significant effect on activity of enzyme-loaded PEC nanoparticles mixed with HPG solutions. However, fast addition of chemicals during the preparations showed smaller particle size compared to the drop-wise method. PEC nanoparticles (PECNPs) also protected both enzymes from denaturation at elevated temperature and pH. Following preparation, enzyme-loaded PEC nanoparticles were mixed with borate crosslinked HPG and the mixture was injected through a shear loop. Pectinase-loaded nanoparticles mixed with gelled HPG showed no sensitivity to shear applied along the shear loop at 25 °C. However, EL2X-loaded PEC nanoparticles showed sensitivity to shear applied along the shear loop at 40 °C. Filter cake was formed and degraded in a fluid loss cell for borate crosslinked HPG solutions mixed with either enzymes or enzyme-loaded PEC nanoparticles. Cleanup slopes of filter cake degraded using enzyme-loaded PEC nanoparticles and systems with enzymes mixed with HPG gel were significantly higher than for the filter cake formed with HPG gel mixed with no enzyme. In a different application, enzyme-loaded PEC nanoparticles showed significantly slower reduction in viscosity of HPG solution over time compared to the HPG systems mixed with enzyme. Increasing the viscosity of low concentration HPG, used as slick-water, decreases the proppant settling velocity. This is of specific interest in fracturing fluids used for unconventional reservoirs.

  10. Control On Fluid Flow Properties In Sandstone: Interactions Between Diagenesis Processes And Fracture Corridors

    Science.gov (United States)

    Bossennec, Claire; Géraud, Yves; Moretti, Isabelle; Mattioni, Luca

    2016-04-01

    During the development of a fault zone, processes occur at different scales: secondary faults and fractures development in the damage zone while "diagenetic" processes, i.e: fluid rock interaction at the grains size scale, contribute to modify the matrix features. Spatial distribution of these processes is clearly controlled by microstructural transformations induced by fractured corridors and their location. Understanding flowing properties in the associated damage zone contributes to the better modeling of the fluid flow in faulted and fractured reservoirs which could be oil, gas or water bearing. The Lower Triassic Buntsandstein sandstones outcrop of Cleebourg is located in the Hochwald Horst affected by a major NNE-SSW striking fault, and the structure globally dips with 30° toward Rhenish Fault (Upper Rhine Graben main western border fault). The study of the outcrop aims to decipher the fluid-flow scheme and interactions between fracture network and diagenetic features distribution in the damage zone of a fault, located close to major faulted areas, through field and laboratories petrophysical measurements (permeability, thermic conductivity), and samples microstructural and diagenetical descriptions. The outcrop is structurally divided into a 14 meters thick fault core, surrounded by 5 meters thick transition zones, and damage zone of minimum thickness of 40 meters (total thickness unknown, due to the limits of the outcrop). Damage zone includes three fractured corridors, perpendicular to bedding and from 2 to 5 meters thick. Results presented here were acquired in 2 different layers with similar lithology but only on damage zone samples. In entire damage zone, porosity results and thin section description allow to distinguish two different facies: • Fa1 Intermediate porous (porosity of 12%) sandstone with major illite cement and clay content up to 20% (detrital and diagenetic); • Fa2 High porous (porosity >15%) sandstone with quartz feeding

  11. Space Station fluid management logistics

    Science.gov (United States)

    Dominick, Sam M.

    1990-01-01

    Viewgraphs and discussion on space station fluid management logistics are presented. Topics covered include: fluid management logistics - issues for Space Station Freedom evolution; current fluid logistics approach; evolution of Space Station Freedom fluid resupply; launch vehicle evolution; ELV logistics system approach; logistics carrier configuration; expendable fluid/propellant carrier description; fluid carrier design concept; logistics carrier orbital operations; carrier operations at space station; summary/status of orbital fluid transfer techniques; Soviet progress tanker system; and Soviet propellant resupply system observations.

  12. Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort.

    Directory of Open Access Journals (Sweden)

    Lyzel S Elias-Sonnenschein

    Full Text Available OBJECTIVES: To understand the relation between risk genes for Alzheimer's disease (AD and their influence on biomarkers for AD, we examined the association of AD in the Finnish cohort with single nucleotide polymorphisms (SNPs from top AlzGene loci, genome-wide association studies (GWAS, and candidate gene studies; and tested the correlation between these SNPs and AD markers Aβ(1-42, total tau (t-tau, and phosphorylated tau (p-tau in cerebrospinal fluid (CSF. METHODS: We tested 25 SNPs for genetic association with clinical AD in our cohort comprised of 890 AD patients and 701-age matched healthy controls using logistic regression. For the correlational study with biomarkers, we tested 36 SNPs in a subset of 222 AD patients with available CSF using mixed models. Statistical analyses were adjusted for age, gender and APOE status. False discovery rate for multiple testing was applied. All participants were from academic hospital and research institutions in Finland. RESULTS: APOE-ε4, CLU rs11136000, and MS4A4A rs2304933 correlated with significantly decreased Aβ(1-42 (corrected p0.05. CONCLUSIONS: We provide evidence that APOE-ε4, CLU and MS4A4A, which have been identified in GWAS to be associated with AD, also significantly reduced CSF Aβ1-42 in AD. None of the other AlzGene and GWAS loci showed significant effects on CSF tau. The effects of other SNPs on CSF biomarkers and clinical AD diagnosis did not reach statistical significance. Our findings suggest that APOE-ε4, CLU and MS4A4A influence both AD risk and CSF Aβ1-42.

  13. Socio-economic status influences blood pressure control despite equal access to care

    DEFF Research Database (Denmark)

    Paulsen, M S; Andersen, M; Munck, A P

    2012-01-01

    OBJECTIVE: Denmark has a health care system with free and equal access to care irrespective of age and socio-economic status (SES). We conducted a cross-sectional study to investigate a possible association between SES and blood pressure (BP) control of hypertensive patients treated in general...

  14. Physical activity intensity and weight control status among U.S. Adults with diabetes.

    Science.gov (United States)

    Loprinzi, Paul D; Pariser, Gina

    2014-01-01

    We have a limited understanding of the objectively determined physical activity levels by weight control status (i.e., trying to lose weight, trying to maintain weight, and neither trying to lose or maintain weight) among U.S. adults with diabetes. Therefore, this study assessed the association between physical activity and weight control status among U.S. adults with diabetes. Cross-sectional survey. The 2003-2006 National Health and Nutrition Examination Survey (NHANES) was used, which is representative of the U.S. population. Subjects were 733 adults (≥20 years) with diabetes. Participants wore an accelerometer to assess physical activity, and questionnaires were used to assess weight control status and covariates. Multivariate negative binomial regressions were used. After adjustments, and compared to those not trying to lose or maintain their weight, women trying to lose weight engaged in 74% more physical activity (rate ratio = 1.74; 95% confidence interval [CI]: 1.14 to 2.65). Although findings were not significant for men, men were more likely than women to meet physical activity recommendations. Diabetic women trying to lose weight engaged in more physical activity than did their female counterparts not trying to lose or maintain their weight. Although men were more active than women, no differences in activity estimates occurred across weight control status for men.

  15. Global Status of DDT and Its Alternatives for Use in Vector Control to Prevent Disease

    NARCIS (Netherlands)

    Berg, van den H.

    2009-01-01

    Objective - I review the status of dichlorodiphenyltrichloroethane (DDT), used for disease vector control, along with current evidence on its benefits and risks in relation to the available alternatives. Data sources and extraction - Contemporary data on DDT use were largely obtained from questionna

  16. Recovery from near drowning and postanoxic status epilepticus with controlled hypothermia

    NARCIS (Netherlands)

    de Pont, A C J M; de Jager, C P C; van den Bergh, W M; Schultz, M J

    2011-01-01

    A diver was resuscitated after cardiac arrest due to near drowning and was hypothermic on hospital arrival. During rewarming, status epilepticus occurred, previously identified as a predictor of poor outcome. The seizures responded well to treatment with antiepileptic drugs and controlled hypothermi

  17. Clustering of cardiovascular risk factors and hypertension control status among hypertensive patients in the outpatient setting

    Institute of Scientific and Technical Information of China (English)

    刘军

    2014-01-01

    Objective To investigate the status of the clustering of cardiovascular risk factors and hypertension control among hypertensive patients in the outpatient setting in China.Methods This multi-center cross-sectional study was carried out from June to December 2009.Study patients were consecutively recruited from 46

  18. Global Status of DDT and Its Alternatives for Use in Vector Control to Prevent Disease

    NARCIS (Netherlands)

    Berg, van den H.

    2009-01-01

    Objective - I review the status of dichlorodiphenyltrichloroethane (DDT), used for disease vector control, along with current evidence on its benefits and risks in relation to the available alternatives. Data sources and extraction - Contemporary data on DDT use were largely obtained from

  19. [Current situation of endemic status, prevention and control of neglected zoonotic diseases in China].

    Science.gov (United States)

    Liu, Lu; Zhu, Hong-Run; Yang, Guo-Jing

    2013-06-01

    Neglected zoonotic diseases not only threaten the health of human, especially to the livestock keepers in poverty-stricken areas but also cause great economic losses to the animal husbandry. This paper reviews the current situation of the endemic status, prevention and control of neglected zoonotic diseases existing in China including rabies, bovine tuberculosis, brucellosis, anthrax, leptospirosis, echinococcosis, cysticercosis, leishmaniasis and fascioliasis, so as to provide the basic information for better controlling, even eliminating, the neglected zoonotic diseases in China.

  20. Design of a new engine mount for vertical and horizontal vibration control using magnetorheological fluid

    Science.gov (United States)

    Phu, D. X.; Choi, S. B.; Lee, Y. S.; Han, M. S.

    2014-10-01

    This paper presents a new design of a magnetorheological fluid (MR) mount for vibration control considering both vertical forces and horizontal moments such as are met in various engine systems, including a medium high-speed engine of ship. The newly designed mount, called a MR brake mount, offers several salient benefits such as small size and relatively high load capacity compared with a conventional MR engine mount that can control vertical vibration only. The principal design parameters of the proposed mount are optimally determined to achieve maximum torque with geometric and spatial constraints. Subsequently, the proposed MR mount is designed and manufactured based on the optimized design parameters. It is shown from experimental testing that the proposed mount, which combines MR mount with MR brake, can produce the desired force and torque to reduce unwanted vibration of a medium high-speed engine system of ship subjected to both vertical and horizontal exciting motions. In addition, it is verified that there is no large difference between experiment results and simulation results that are obtained from an analytical model derived in this work.

  1. Force-feedback control of a spherical haptic device featuring an electrorheological fluid

    Science.gov (United States)

    Han, Young-Min; Choi, Seung-Bok

    2006-10-01

    This paper presents the force-feedback performance of an active type of haptic device featuring an electrorheological (ER) fluid via a sliding mode controller (SMC), which is very robust to external disturbances and parameter uncertainties. In order to generate a 2-degrees-of-freedom (2-DOF) active force, a spherical ER joint is designed based on the mathematical torque model. The ER joint is then manufactured by adopting two bi-directional clutch actuators and the spherical geometry of the electrode, and its field-dependent generating force is experimentally evaluated. Subsequently, the 2-DOF force display is manufactured by integrating the ER joint with AC motors. The force response of the manufactured haptic device is experimentally evaluated, and expressed by a second-order dynamic equation. In order to achieve the desired force trajectories, the SMC is formulated and experimentally realized by imposing an Euler angle relationship. Tracking control performances for various force trajectories are presented in the time domain, and their tracking errors are evaluated.

  2. Challenges with Tertiary-Level Mechatronic Fluid Power

    DEFF Research Database (Denmark)

    Dransfield, Peter; Conrad, Finn

    1996-01-01

    As authors we take the view that mechatronics, as it relates to fluid power, has three levels which we designate as primary, secondary and tertiary. A brief review of the current status of fluid power, hydraulic and pneumatic, and of electronic control of it is presented and discussed. The focus...... is then on tertiary-level mechatronic fluid power and the challenges to it being applied successfully....

  3. Pediatric Diabetic Ketoacidosis, Fluid Therapy and Cerebral Injury: The Design of a Factorial Randomized Controlled Trial

    OpenAIRE

    Glaser, Nicole S.; Ghetti, Simona; Casper, T. Charles; Dean, J. Michael; Kuppermann, Nathan

    2013-01-01

    Treatment protocols for pediatric diabetic ketoacidosis (DKA) vary considerably among centers in the United States and worldwide. The optimal protocol for intravenous fluid administration is an area of particular controversy, mainly in regard to possible associations between rates of intravenous fluid infusion and the development of cerebral edema, the most common and most feared complication of DKA in children. Theoretical concerns about associations between osmotic fluid shifts and cerebral...

  4. Water drilling fluids: evaluation of lubricity and clay swelling control; Fluidos de perfuracao a base de agua: avaliacao de lubricidade e controle de inchamento de argilas

    Energy Technology Data Exchange (ETDEWEB)

    Felix, Thiago de Freitas; Arruda, Jefferson Teixeira; Medeiros, Ana Catarina; Garcia, Rosangela Balaban [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil)

    2008-07-01

    During the oil well drilling, drilling fluids are used in order to transport the cuttings until the surface. This fluid is also responsible for the mechanical sustentation of the well walls, the control of undesirable production of fluids in the formation, the lubricity and the cooling of the bit. The drilling fluids based on water are extensively applied due to their lower cost, thermal stability, biodegradability, easiness of pumping and treatment, resulting in smaller environmental impacts. However, some situations, such as hydrophilic shale drilling, request the use of additives to avoid the hydration of them and, consequently, the tool imprisonment or migration (filtration) of the drilling fluids into the rock. The goal of this work was to develop and test formulations of water-base drilling fluids with high capacity of inhibition of clay swelling and lubricity, obtaining drillings with larger penetration rate and calipers without enlargements. The results showed that the appropriate combination of commonly used commercial products can promote the obtaining of fluids with equal or better performance than those used by world companies. (author)

  5. Study of Fluid Flow Control in Protein Crystallization using Strong Magnetic Fields

    Science.gov (United States)

    Ramachandran, Narayanan; Leslie, Fred; Ciszak, Ewa

    2002-01-01

    An important component in biotechnology, particularly in the area of protein engineering and rational drug design is the knowledge of the precise three-dimensional molecular structure of proteins. The quality of structural information obtained from X-ray diffraction methods is directly dependent on the degree of perfection of the protein crystals. As a consequence, the growth of high quality macromolecular crystals for diffraction analyses has been the central focus for biochemists, biologists, and bioengineers. Macromolecular crystals are obtained from solutions that contain the crystallizing species in equilibrium with higher aggregates, ions, precipitants, other possible phases of the protein, foreign particles, the walls of the container, and a likely host of other impurities. By changing transport modes in general, i.e., reduction of convection and sedimentation, as is achieved in "microgravity", researchers have been able to dramatically affect the movement and distribution of macromolecules in the fluid, and thus their transport, formation of crystal nuclei, and adsorption to the crystal surface. While a limited number of high quality crystals from space flights have been obtained, as the recent National Research Council (NRC) review of the NASA microgravity crystallization program pointed out, the scientific approach and research in crystallization of proteins has been mainly empirical yielding inconclusive results. We postulate that we can reduce convection in ground-based experiments and we can understand the different aspects of convection control through the use of strong magnetic fields and field gradients. Whether this limited convection in a magnetic field will provide the environment for the growth of high quality crystals is still a matter of conjecture that our research will address. The approach exploits the variation of fluid magnetic susceptibility with concentration for this purpose and the convective damping is realized by appropriately

  6. The Serum Antioxidant Status in Chinese Subjects with Metabolic Syndrome:a Case-Control Study

    Institute of Scientific and Technical Information of China (English)

    Yan-rong LI; Kun XUE; Hong-wei GUO; Min WU; Ming LIU

    2014-01-01

    Objective To investigate serum antioxidant status in subjects with metabolic syndrome (MS) and analyze the association between serum antioxidant status and MS components.MethodsA case-control study was conducted with 221 MS cases and 329 controls aged 18-70 years. Weight, height, body mass index, waist circumference, blood pressure, fasting blood glucose and lipids, as well as serum superoxide dismutase (SOD), glutathione peroxidase(GSH-Px), malondialdehyde (MDA), vitamin E,β-carotene and lycopene were examined.Results Mean serum SOD activity,β-carotene level were significantly lower, and MDA higher (P<0.05) in MS subjects than in controls after adjusting for age and gender. Serum SOD, GSH-Px andβ-carotene level were also decreased significantly (P<0.05) with increased number of MS components.Conclusion Serum antioxidant status was negatively correlated with risks of MS and lower SOD activity andβ-carotene level appeared to be associated with more MS components. Serum oxidative status is useful in assessing the severity of MS.

  7. Awareness of high blood pressure status, treatment and control in a rural community in Edo State.

    Science.gov (United States)

    Omuemu, V O; Okojie, O H; Omuemu, C E

    2007-09-01

    A cross-sectional study was carried out in Udo, a rural community in Ovia South-west LGA of Edo State to assess the level of awareness of high blood pressure status, treatment and control. Cluster sampling method was used to select participants and data collection was by researcher administered questionnaire. Blood pressure measurement was by standardized method. A total of 590 respondents with mean age 30.7 +/- 14.6 years participated in the study. The prevalence of hypertension was 20.2% using the WHO/ISH criteria of SBP > or = 140 mmHg and/or DBP > or = 90 mmHg. Twenty two (18.5%) of the hypertensives were aware of their high blood pressure status. Awareness was higher in females, increased with age and decreased with higher educational status. Of those aware of their condition, 77.3% were on treatment and ofthese, 29.4% had adequate blood pressure control. This study has revealed a low level of awareness of high blood pressure status and control in this rural community. Therefore, there is urgent need for regular community-based hypertension screening programmes.

  8. The effect of functional status of the ovaries on the embryological results of controlled ovarian hyperstimulation

    Directory of Open Access Journals (Sweden)

    Grzegorz Mrugacz

    2013-12-01

    Full Text Available Introduction: Controlled ovarian hyperstimulation is an integral part of infertility treatment. Despite many years of use, some aspects of controlled ovarian stimulation have not yet been clarified, especially the role of the functional status of the ovaries before hormonal stimulation. Aim of the research: To assess the effect of the functional status of the ovaries on the embryological results of controlled ovarian hyperstimulation. Material and methods: The retrospective study included female patients treated for infertility. The patients were divided into two groups depending on the ultrasonographic appearance of the ovaries before controlled ovarian hyperstimulation. Patients with small antral follicles 0.05. The numbers of A, C, D quality embryos were comparable between the groups (p > 0.05. There were more B quality embryos in group I than II (p > 0.05. The embryo growth rate was significantly faster in group I than II. Conclusions: The results of the present study indicate that the functional status of the ovaries before controlled ovarian hyperstimulation plays a pivotal role in treatment outcome.

  9. Control and Automation of Fluid Flow, Mass Transfer and Chemical Reactions in Microscale Segmented Flow

    Science.gov (United States)

    Abolhasani, Milad

    Flowing trains of uniformly sized bubbles/droplets (i.e., segmented flows) and the associated mass transfer enhancement over their single-phase counterparts have been studied extensively during the past fifty years. Although the scaling behaviour of segmented flow formation is increasingly well understood, the predictive adjustment of the desired flow characteristics that influence the mixing and residence times, remains a challenge. Currently, a time consuming, slow and often inconsistent manual manipulation of experimental conditions is required to address this task. In my thesis, I have overcome the above-mentioned challenges and developed an experimental strategy that for the first time provided predictive control over segmented flows in a hands-off manner. A computer-controlled platform that consisted of a real-time image processing module within an integral controller, a silicon-based microreactor and automated fluid delivery technique was designed, implemented and validated. In a first part of my thesis I utilized this approach for the automated screening of physical mass transfer and solubility characteristics of carbon dioxide (CO2) in a physical solvent at a well-defined temperature and pressure and a throughput of 12 conditions per hour. Second, by applying the segmented flow approach to a recently discovered CO2 chemical absorbent, frustrated Lewis pairs (FLPs), I determined the thermodynamic characteristics of the CO2-FLP reaction. Finally, the segmented flow approach was employed for characterization and investigation of CO2-governed liquid-liquid phase separation process. The second part of my thesis utilized the segmented flow platform for the preparation and shape control of high quality colloidal nanomaterials (e.g., CdSe/CdS) via the automated control of residence times up to approximately 5 minutes. By introducing a novel oscillatory segmented flow concept, I was able to further extend the residence time limitation to 24 hours. A case study of a

  10. Computational Fluid Dynamics Based Investigation of Sensitivity of Furnace Operational Conditions to Burner Flow Controls

    Energy Technology Data Exchange (ETDEWEB)

    Marc Cremer; Kirsi St. Marie; Dave Wang

    2003-04-30

    This is the first Semiannual Technical Report for DOE Cooperative Agreement No: DE-FC26-02NT41580. The goal of this project is to systematically assess the sensitivity of furnace operational conditions to burner air and fuel flows in coal fired utility boilers. Our approach is to utilize existing baseline furnace models that have been constructed using Reaction Engineering International's (REI) computational fluid dynamics (CFD) software. Using CFD analyses provides the ability to carry out a carefully controlled virtual experiment to characterize the sensitivity of NOx emissions, unburned carbon (UBC), furnace exit CO (FECO), furnace exit temperature (FEGT), and waterwall deposition to burner flow controls. The Electric Power Research Institute (EPRI) is providing co-funding for this program, and instrument and controls experts from EPRI's Instrument and Controls (I&C) Center are active participants in this project. This program contains multiple tasks and good progress is being made on all fronts. A project kickoff meeting was held in conjunction with NETL's 2002 Sensors and Control Program Portfolio Review and Roadmapping Workshop, in Pittsburgh, PA during October 15-16, 2002. Dr. Marc Cremer, REI, and Dr. Paul Wolff, EPRI I&C, both attended and met with the project COR, Susan Maley. Following the review of REI's database of wall-fired coal units, the project team selected a front wall fired 150 MW unit with a Riley Low NOx firing system including overfire air for evaluation. In addition, a test matrix outlining approximately 25 simulations involving variations in burner secondary air flows, and coal and primary air flows was constructed. During the reporting period, twenty-two simulations have been completed, summarized, and tabulated for sensitivity analysis. Based on these results, the team is developing a suitable approach for quantifying the sensitivity coefficients associated with the parametric tests. Some of the results of the CFD

  11. Simulation of a Canard in Fluid Flow Driven by a Piezoelectric Beam with a Software Control Loop

    Science.gov (United States)

    2014-04-01

    physical phenomena. The objective of this report is to model the actuation of a canard that could be used to control a projectile . To include the fluid...Figure 11 shows case one, where the voltage is quickly ramped up and kept constant. The canard angle shows how the canard motion damps out over time

  12. A Randomized Controlled Design Investigating the Effects of Classroom-Based Physical Activity on Children's Fluid Intelligence and Achievement

    Science.gov (United States)

    Fedewa, Alicia L.; Ahn, Soyeon; Erwin, Heather; Davis, Matthew C.

    2015-01-01

    Existing literature shows promising effects of physical activity on children's cognitive outcomes. This study assessed via a randomized, controlled design whether additional curricular physical activity during the school day resulted in gains for children's fluid intelligence and standardized achievement outcomes. Participants were children…

  13. 46 CFR 61.20-3 - Main and auxiliary machinery and associated equipment, including fluid control systems.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Main and auxiliary machinery and associated equipment... SECURITY (CONTINUED) MARINE ENGINEERING PERIODIC TESTS AND INSPECTIONS Periodic Tests of Machinery and Equipment § 61.20-3 Main and auxiliary machinery and associated equipment, including fluid control...

  14. Direct control of the small-scale energy balance in two-dimensional fluid dynamics

    NARCIS (Netherlands)

    Frank, Jason; Leimkuhler, Benedict; Myerscough, Keith W.

    2015-01-01

    We explore the direct modification of the pseudo-spectral truncation of two-dimensional, incompressible fluid dynamics to maintain a prescribed kinetic energy spectrum. The method provides a means of simulating fluid states with defined spectral properties, for the purpose of matching simulation sta

  15. The effects of chronic periodontitis and rheumatoid arthritis on serum and gingival crevicular fluid total antioxidant/oxidant status and oxidative stress index.

    Science.gov (United States)

    Esen, Cağrı; Alkan, Banu Arzu; Kırnap, Mehmet; Akgül, Ozgür; Işıkoğlu, Semra; Erel, Ozcan

    2012-06-01

    Chronic periodontitis (CP) and rheumatoid arthritis (RA) appear to share many pathologic features. Oxygen metabolism has an important role in the pathogenesis of both CP and RA. The aim of this study is to evaluate the relationship between these two chronic inflammatory diseases with regard to antioxidant and oxidant status. A total of 80 participants were divided into four groups of 20 each: group RA-CP (patients with RA and CP), group RA (periodontally healthy patients with RA), group CP (systemically healthy patients with CP), and group C (periodontally and systemically healthy volunteers) were included in the study. After assessment of periodontal measurements, gingival crevicular fluid (GCF) samples were taken at one incisor, premolar, and molar tooth and stored with serum samples at -80°C for the antioxidant/oxidant assay. Although all clinical measurements in groups RA-CP and CP were statistically higher compared to those of C and RA groups (P 0.05). GCF total oxidant status (TOS) values of CP and RA-CP groups were higher than those of the RA group (P oxidative stress index (OSI) values of the RA-CP group were higher than those of the RA group (P 0.05). Local OSI values in groups with patients with CP were higher, whereas systemic OSI values showed no difference among the groups. The presence of RA seems not to affect local and systemic OSI values in patients with CP.

  16. Cerebrospinal fluid cortisol levels are higher in patients with delirium versus controls

    Directory of Open Access Journals (Sweden)

    White Timothy O

    2010-02-01

    Full Text Available Abstract Background High plasma cortisol levels can cause acute cognitive and neuropsychiatric dysfunction, and have been linked with delirium. CSF cortisol levels more closely reflect brain exposure to cortisol, but there are no studies of CSF cortisol levels in delirium. In this pilot study we acquired CSF specimens at the onset of spinal anaesthesia in patients undergoing hip fracture surgery, and compared CSF and plasma cortisol levels in delirium cases versus controls. Findings Delirium assessments were performed the evening before or on the morning of operation with a standard battery comprising cognitive tests, mental status assessments and the Confusion Assessment Method. CSF and plasma samples were obtained at the onset of the operation and cortisol levels measured. Twenty patients (15 female, 5 male aged 62 - 93 years were studied. Seven patients were diagnosed with delirium. The mean ages of cases (81.4 (SD 7.2 and controls (80.5 (SD 8.7 were not significantly different (p = 0.88. The median (interquartile range CSF cortisol levels were significantly higher in cases (63.9 (40.4-102.1 nmol/L than controls (31.4 (21.7-43.3 nmol/L; Mann-Whitney U, p = 0.029. The median (interquartile range of plasma cortisol was also significantly higher in cases (968.8 (886.2-1394.4 nmol/L, than controls (809.4 (544.0-986.4 nmol/L; Mann Whitney U, p = 0.036. Conclusions These findings support an association between higher CSF cortisol levels and delirium. This extends previous findings linking higher plasma cortisol and delirium, and suggests that more definitive studies of the relationship between cortisol levels and delirium are now required.

  17. Impact of postoperative glycemic control and nutritional status on clinical outcomes after total pancreatectomy

    Science.gov (United States)

    Shi, Hao-Jun; Jin, Chen; Fu, De-Liang

    2017-01-01

    AIM To evaluate the impact of glycemic control and nutritional status after total pancreatectomy (TP) on complications, tumor recurrence and overall survival. METHODS Retrospective records of 52 patients with pancreatic tumors who underwent TP were collected from 2007 to 2015. A series of clinical parameters collected before and after surgery, and during the follow-up were evaluated. The associations of glycemic control and nutritional status with complications, tumor recurrence and long-term survival were determined. Risk factors for postoperative glycemic control and nutritional status were identified. RESULTS High early postoperative fasting blood glucose (FBG) levels (OR = 4.074, 95%CI: 1.188-13.965, P = 0.025) and low early postoperative prealbumin levels (OR = 3.816, 95%CI: 1.110-13.122, P = 0.034) were significantly associated with complications after TP. Postoperative HbA1c levels over 7% (HR = 2.655, 95%CI: 1.299-5.425, P = 0.007) were identified as one of the independent risk factors for tumor recurrence. Patients with postoperative HbA1c levels over 7% had much poorer overall survival than those with HbA1c levels less than 7% (9.3 mo vs 27.6 mo, HR = 3.212, 95%CI: 1.147-8.999, P = 0.026). Patients with long-term diabetes mellitus (HR = 15.019, 95%CI: 1.278-176.211, P = 0.031) and alcohol history (B = 1.985, SE = 0.860, P = 0.025) tended to have poor glycemic control and lower body mass index levels after TP, respectively. CONCLUSION At least 3 mo are required after TP to adapt to diabetes and recover nutritional status. Glycemic control appears to have more influence over nutritional status on long-term outcomes after TP. Improvement in glycemic control and nutritional status after TP is important to prevent early complications and tumor recurrence, and improve survival.

  18. Animated sulfonated or sulformethylated lignins as cement fluid loss control additives

    Energy Technology Data Exchange (ETDEWEB)

    Schilling, P.

    1991-05-07

    This patent describes a method of cementing a zone in a well penetrating a subterranean formation comprising injecting down the well and positioning in the zone to be cemented a hydraulic aqueous cement slurry composition. It comprises: a hydraulic cement, and the following expressed as parts by weight per 100 parts of the hydraulic cement, water from about 25 to 105 parts, and a fluid loss control additive comprising from about 0.5 to 2.5 parts of a compound selected from the group consisting of a sulfonated lignin and a sulfomethylated lignin, wherein the lignin has been aminated by reacting it with between about 2-5 moles of a polyamine and 2-5 moles of an aldehyde per 1,000g of the lignin, and 0.1 to 1.5 parts of a compound selected from the group consisting of sodium carbonate, sodium metasilicate, sodium phosphate, sodium sulfite and sodium naphthalene sulfonate and a combination thereof.

  19. Optimization of new magnetorheological fluid mount for vibration control of start/stop engine mode

    Science.gov (United States)

    Chung, Jye Ung; Phu, Do Xuan; Choi, Seung-Bok

    2015-04-01

    The technologies related to saving energy/or green vehicles are actively researched. In this tendency, the problem for reducing exhausted gas is in development with various ways. Those efforts are directly related to the operation of engine which emits exhausted gas. The auto start/stop of vehicle engine when a vehicle stop at road is currently as a main stream of vehicle industry resulting in reducing exhausted gas. However, this technology automatically turns on and off engine frequently. This motion induces vehicle engine to transmit vibration of engine which has large displacement, and torsional impact to chassis. These vibrations causing uncomfortable feeling to passengers are transmitted through the steering wheel and the gear knob. In this work, in order to resolve this vibration issue, a new proposed magnetorheological (MR) fluid based engine mount (MR mount in short) is presented. The proposed MR mount is designed to satisfy large damping force in various frequency ranges. It is shown that the proposed mount can have large damping force and large force ratio which is enough to control unwanted vibrations of engine start/stop mode.

  20. CDIO-Concept for Enginering Education in Fluid Power, Motion Control and Mechatronic Design

    DEFF Research Database (Denmark)

    Conrad, Finn; Sørensen, Torben

    2006-01-01

    The paper presents significant Danish experiment results of a developed CDIO-Concept and approach for active and integrated learning in today’s engineering education of MSc Degree students, and research results from using IT-Tools for CAE/CAD and dynamic modelling, simulation, analysis, and desig...... mechatronics design, and advantages as well as challenges are identified and discussed. An IT-tool concept for modelling, simulation and design of mechatronic products and systems is proposed.......The paper presents significant Danish experiment results of a developed CDIO-Concept and approach for active and integrated learning in today’s engineering education of MSc Degree students, and research results from using IT-Tools for CAE/CAD and dynamic modelling, simulation, analysis, and design...... of mechatronics solutions with fluid power actuators for motion control of machines and robots. The idea of CDIO-Concept is to take care of that the students are learning by doing and learning while doing when the students are active to generate new products and solutions by going through the phases from...

  1. Protocol for quality control in metabolic profiling of biological fluids by U(H)PLC-MS.

    Science.gov (United States)

    Gika, Helen G; Zisi, Chrysostomi; Theodoridis, Georgios; Wilson, Ian D

    2016-01-01

    The process of untargeted metabolic profiling/phenotyping of complex biological matrices, i.e., biological fluids such as blood plasma/serum, saliva, bile, and tissue extracts, provides the analyst with a wide range of challenges. Not the least of these challenges is demonstrating that the acquired data are of "good" quality and provide the basis for more detailed multivariate, and other, statistical analysis necessary to detect, and identify, potential biomarkers that might provide insight into the process under study. Here straightforward and pragmatic "quality control (QC)" procedures are described that allow investigators to monitor the analytical processes employed for global, untargeted, metabolic profiling. The use of this methodology is illustrated with an example from the analysis of human urine where an excel spreadsheet of the preprocessed LC-MS output is provided with embedded macros, calculations and visualization plots that can be used to explore the data. Whilst the use of these procedures is exemplified on human urine samples, this protocol is generally applicable to metabonomic/metabolomic profiling of biofluids, tissue and cell extracts from many sources. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. Matrix mechanics and fluid shear stress control stem cells fate in three dimensional microenvironment.

    Science.gov (United States)

    Chen, Guobao; Lv, Yonggang; Guo, Pan; Lin, Chongwen; Zhang, Xiaomei; Yang, Li; Xu, Zhiling

    2013-07-01

    Stem cells have the ability to self-renew and to differentiate into multiple mature cell types during early life and growth. Stem cells adhesion, proliferation, migration and differentiation are affected by biochemical, mechanical and physical surface properties of the surrounding matrix in which stem cells reside and stem cells can sensitively feel and respond to the microenvironment of this matrix. More and more researches have proven that three dimensional (3D) culture can reduce the gap between cell culture and physiological environment where cells always live in vivo. This review summarized recent findings on the studies of matrix mechanics that control stem cells (primarily mesenchymal stem cells (MSCs)) fate in 3D environment, including matrix stiffness and extracellular matrix (ECM) stiffness. Considering the exchange of oxygen and nutrients in 3D culture, the effect of fluid shear stress (FSS) on fate decision of stem cells was also discussed in detail. Further, the difference of MSCs response to matrix stiffness between two dimensional (2D) and 3D conditions was compared. Finally, the mechanism of mechanotransduction of stem cells activated by matrix mechanics and FSS in 3D culture was briefly pointed out.

  3. Cerebrospinal Fluid Biomarkers of Japanese Encephalitis [v2; ref status: indexed, http://f1000r.es/5uq

    Directory of Open Access Journals (Sweden)

    Nabonita Sengupta

    2015-09-01

    Full Text Available Japanese encephalitis (JE is the leading cause of viral encephalitis in Asia. Acute encephalitis syndrome (AES is a group of central nervous system (CNS disorders caused by a wide range of viruses, bacteria, fungi, chemicals and toxins. It is important to distinguish between various forms of infectious encephalitis with similar clinical manifestations in order to ensure specific and accurate diagnosis and development of subsequent therapeutic strategies. Cerebrospinal fluid (CSF is in direct contact with the CNS and hence it is considered to be an excellent source for identifying biomarkers for various neurological disorders. With the recent advancement in proteomic methodologies, the field of biomarker research has received a remarkable boost.  The present study identifies potential biomarkers for JE using a proteomics based approach. The CSF proteomes from ten patients each with JE and Non-JE acute encephalitis were analyzed by 2D gel electrophoresis followed by mass spectrometry. Vitamin D-binding protein (DBP, fibrinogen gamma chain, fibrinogen beta chain, complement C4-B, complement C3 and cytoplasmic actin were found to be significantly elevated in case of JE indicating severe disruption of the blood brain barrier and DBP can be suggested to be an important diagnostic marker.

  4. Extracorporeal Ultrafiltration for Fluid Overload in Heart Failure: Current Status and Prospects for Further Research.

    Science.gov (United States)

    Costanzo, Maria Rosa; Ronco, Claudio; Abraham, William T; Agostoni, Piergiuseppe; Barasch, Jonathan; Fonarow, Gregg C; Gottlieb, Stephen S; Jaski, Brian E; Kazory, Amir; Levin, Allison P; Levin, Howard R; Marenzi, Giancarlo; Mullens, Wilfried; Negoianu, Dan; Redfield, Margaret M; Tang, W H Wilson; Testani, Jeffrey M; Voors, Adriaan A

    2017-05-16

    More than 1 million heart failure hospitalizations occur annually, and congestion is the predominant cause. Rehospitalizations for recurrent congestion portend poor outcomes independently of age and renal function. Persistent congestion trumps serum creatinine increases in predicting adverse heart failure outcomes. No decongestive pharmacological therapy has reduced these harmful consequences. Simplified ultrafiltration devices permit fluid removal in lower-acuity hospital settings, but with conflicting results regarding safety and efficacy. Ultrafiltration performed at fixed rates after onset of therapy-induced increased serum creatinine was not superior to standard care and resulted in more complications. In contrast, compared with diuretic agents, some data suggest that adjustment of ultrafiltration rates to patients' vital signs and renal function may be associated with more effective decongestion and fewer heart failure events. Essential aspects of ultrafiltration remain poorly defined. Further research is urgently needed, given the burden of congestion and data suggesting sustained benefits of early and adjustable ultrafiltration. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  5. Testing of the Engineering Model Electrical Power Control Unit for the Fluids and Combustion Facility

    Science.gov (United States)

    Kimnach, Greg L.; Lebron, Ramon C.; Fox, David A.

    1999-01-01

    The John H. Glenn Research Center at Lewis Field (GRC) in Cleveland, OH and the Sundstrand Corporation in Rockford, IL have designed and developed an Engineering Model (EM) Electrical Power Control Unit (EPCU) for the Fluids Combustion Facility, (FCF) experiments to be flown on the International Space Station (ISS). The EPCU will be used as the power interface to the ISS power distribution system for the FCF's space experiments'test and telemetry hardware. Furthermore. it is proposed to be the common power interface for all experiments. The EPCU is a three kilowatt 12OVdc-to-28Vdc converter utilizing three independent Power Converter Units (PCUs), each rated at 1kWe (36Adc @ 28Vdc) which are paralleled and synchronized. Each converter may be fed from one of two ISS power channels. The 28Vdc loads are connected to the EPCU output via 48 solid-state and current-limiting switches, rated at 4Adc each. These switches may be paralleled to supply any given load up to the 108Adc normal operational limit of the paralleled converters. The EPCU was designed in this manner to maximize allocated-power utilization. to shed loads autonomously, to provide fault tolerance. and to provide a flexible power converter and control module to meet various ISS load demands. Tests of the EPCU in the Power Systems Facility testbed at GRC reveal that the overall converted-power efficiency, is approximately 89% with a nominal-input voltage of 12OVdc and a total load in the range of 4O% to 110% rated 28Vdc load. (The PCUs alone have an efficiency of approximately 94.5%). Furthermore, the EM unit passed all flight-qualification level (and beyond) vibration tests, passed ISS EMI (conducted, radiated. and susceptibility) requirements. successfully operated for extended periods in a thermal/vacuum chamber, was integrated with a proto-flight experiment and passed all stability and functional requirements.

  6. Control of fluid flow during Bridgman crystal growth using low-frequency vibrational stirring

    Science.gov (United States)

    Zawilski, Kevin Thomas

    The goal of this research program was to develop an in depth understanding of a promising new method for stirring crystal growth melts called coupled vibrational stirring (CVS). CVS is a mixing technique that can be used in sealed systems and produces rapid mixing through vortex flows. Under normal operating conditions, CVS uses low-frequency vibrations to move the growth crucible along a circular path, producing a surface wave and convection in the melt. This research focused on the application of CVS to the vertical Bridgman technique. CVS generated flows were directly studied using a physical modeling system containing water/glycerin solutions. Sodium nitrate was chosen as a model growth system because the growth process could be directly observed using a transparent furnace. Lead magnesium niobate-lead titanate (PMNT) was chosen as the third system because of its potential application for high performance solid state transducers and actuators. In this study, the critical parameters for controlling CVS flows in cylindrical Bridgman systems were established. One of the most important results obtained was the dependence of an axial velocity gradient on the vibrational frequency. By changing the frequency, the intensity of fluid flow at a given depth can be easily manipulated. The intensity of CVS flows near the crystal-melt interface was found to be important. When flow intensity near the interface increased during growth, large growth rate fluctuations and significant changes in interface shape were observed. To eliminate such fluctuations, a constant flow rate near the crystal-melt interface was maintained by decreasing the vibrational frequency. A continuous frequency ramp was found to be essential to grow crystals of good quality under strong CVS flows. CVS generated flows were also useful in controlling the shape of the growth interface. In the sodium nitrate system without stirring, high growth rates produced a very concave interface. By adjusting the flow

  7. Plasma paraoxonase, oxidative status level, and their relationship with asthma control test in children with asthma.

    Science.gov (United States)

    Emin, O; Hasan, A; Rusen, D M

    2015-01-01

    Assessment of asthma with a control test has been suggested as a relevant approach in recent years. However, no biomarker of systemic inflammation has been included in the assessment of asthma control. To evaluate plasma paraoxonase (PON1), total oxidant status (TOS), and total antioxidant status (TAS) levels in children with asthma according to the disease control, and the performance in the identification of uncontrolled patients. Stable asthmatic children (n=85) and healthy controls (n=55) were recruited for this study. Blood samples were collected for plasma PON1, TOS, and TAS measurements. Any contributing factors that may affect plasma PON1, TAS, and TOS levels were excluded from both groups. The diagnostic potential of these measures was evaluated using receiver operating characteristic (ROC) analysis. Comparing the asthmatic children with the control group, plasma TAS and TOS levels were significantly higher (TAS; 6.9 ± 2.1, 1.05 ± 0.32, Pasthma, respectively. Asthma Control Test (ACT) presented an AUC of 0.972 for the identification of uncontrolled asthma. PON1 and TOS levels may be systemic markers of uncontrolled asthma in children. Combined use of these two biomarkers with asthma control test may identify patients with uncontrolled asthma in children. Copyright © 2014 SEICAP. Published by Elsevier Espana. All rights reserved.

  8. The fluid control mechanism of bionic structural heterogeneous composite materials and its potential application in enhancing pump efficiency

    Directory of Open Access Journals (Sweden)

    Limei Tian

    2015-11-01

    Full Text Available Studies have shown that the structure of dolphin skin controls fluid media dynamically. Gaining inspiration from this phenomenon, a kind of bionic structural heterogeneous composite material was designed. The bionic structural heterogeneous composite material is composed of two materials: a rigid metal base layer with bionic structures and an elastic polymer surface layer with the corresponding mirror structures. The fluid control mechanism of the bionic structural heterogeneous composite material was investigated using a fluid–solid interaction method in ANSYS Workbench. The results indicated that the bionic structural heterogeneous composite material’s fluid control mechanism is its elastic deformation, which is caused by the coupling action between the elastic surface material and the bionic structure. This deformation can decrease the velocity gradient of the fluid boundary layer through changing the fluid–solid actual contact surface and reduce the frictional force. The bionic structural heterogeneous composite material can also absorb some energy through elastic deformation and avoid energy loss. The bionic structural heterogeneous composite material was applied to the impeller of a centrifugal pump in a contrast experiment, increasing the pump efficiency by 5% without changing the hydraulic model of the impeller. The development of this bionic structural heterogeneous composite material will be straightforward from an engineering point of view, and it will have valuable practical applications.

  9. D evelopment and Testing of a Closed Loop Feedback Controlled Magnetorheological Fluid Anti-vibration Mount for Onboard Naval Applications

    Directory of Open Access Journals (Sweden)

    Reji John

    2016-06-01

    Full Text Available An intelligent semi-active anti-vibration mount using a magnetorheological (MR fluid is designed and developed for onboard applications. The mount consists of a load bearing elastomer, MR fluid chamber; MEMS based vibration sensor and a controller for closed loop feedback mechanism. The controller regulates the solenoid current in the MR fluid chamber, which in turn regulates the flow of MR fluid through the valve. Comparison of the performance of MR mount with a passive resilient rubber mount shows that the former provides 7 dB extra damping at resonance compared to the later and the isolation of MR mount starts at 10 Hz compared to 50 Hz by rubber mount. This mount can operate in real time, passive and active modes by using a closed loop feedback control mechanism. The efficacy of the mount for outdoor applications is evaluated by characterizing the mechanical, environmental, electrical and electromagnetic properties as per MIL-17185, JSS-55555 and IEC 61000 standards and found to be superior compared to passive mounts. The mount is being evaluated for onboard applications in INS Ranvijay.

  10. Systematic Methods for Working Fluid Selection and the Design, Integration and Control of Organic Rankine Cycles—A Review

    Directory of Open Access Journals (Sweden)

    Patrick Linke

    2015-05-01

    Full Text Available Efficient power generation from low to medium grade heat is an important challenge to be addressed to ensure a sustainable energy future. Organic Rankine Cycles (ORCs constitute an important enabling technology and their research and development has emerged as a very active research field over the past decade. Particular focus areas include working fluid selection and cycle design to achieve efficient heat to power conversions for diverse hot fluid streams associated with geothermal, solar or waste heat sources. Recently, a number of approaches have been developed that address the systematic selection of efficient working fluids as well as the design, integration and control of ORCs. This paper presents a review of emerging approaches with a particular emphasis on computer-aided design methods.

  11. Liquefied gaseous fuels safety and environmental control assessment program: third status report

    Energy Technology Data Exchange (ETDEWEB)

    1982-03-01

    This Status Report contains contributions from all contractors currently participating in the DOE Liquefied Gaseous Fuels (LG) Safety and Environmental Control Assessment Program and is presented in two principal sections. Section I is an Executive Summary of work done by all program participants. Section II is a presentation of fourteen individual reports (A through N) on specific LGF Program activities. The emphasis of Section II is on research conducted by Lawrence Livermore National Laboratory (Reports A through M). Report N, an annotated bibliography of literature related to LNG safety and environmental control, was prepared by Pacific Northwest Laboratory (PNL) as part of its LGF Safety Studies Project. Other organizations who contributed to this Status Report are Aerojet Energy Conversion Company; Applied Technology Corporation; Arthur D. Little, Incorporated; C/sub v/ International, Incorporated; Institute of Gas Technology; and Massachusetts Institute of Technology. Separate abstracts have been prepared for Reports A through N for inclusion in the Energy Data Base.

  12. Self-perception of body weight status and weight control practices among adolescents in Malaysia.

    Science.gov (United States)

    Zainuddin, Ahmad Ali; Manickam, Mala A; Baharudin, Azli; Omar, Azahadi; Cheong, Siew Man; Ambak, Rashidah; Ahmad, Mohamad Hasnan; Ghaffar, Suhaila Abdul

    2014-09-01

    The prevalence of overweight and obesity among adolescents is rising rapidly in many countries, including Malaysia. This article aims to present the associations between body mass index-based body weight status, body weight perception, and weight control practices among adolescents in Malaysia. The Malaysia School Based Nutrition Survey 2012, which included a body weight perception questionnaire and anthropometric measurements, was conducted on a representative sample of 40 011 students from Standard 4 until Form 5, with a 90.5% response rate. Comparing actual and perceived body weight status, the findings show that 13.8% of adolescents underestimated their weight, 35.0% overestimated, and 51.2% correctly judged their own weight. Significantly more normal weight girls felt they were overweight, whereas significantly more overweight boys perceived themselves as underweight. The overall appropriateness of weight control practices to body weight was 72.6%. Adolescents attempting to lose or gain weight need to have better understanding toward desirable behavioral changes.

  13. Computational Fluid Dynamics Based Investigation of Sensitivity of Furnace Operational Conditions to Burner Flow Controls

    Energy Technology Data Exchange (ETDEWEB)

    Marc Cremer; Dave Wang; Connie Senior; Andrew Chiodo; Steven Hardy; Paul Wolff

    2005-07-01

    This is the Final Technical Report for DOE Cooperative Agreement No: DE-FC26-02NT41580. The goal of this project was to systematically assess the sensitivity of furnace operational conditions to burner air and fuel flows in coal fired utility boilers. The focus of this project was to quantify the potential impacts of ''fine level'' controls rather than that of ''coarse level'' controls (i.e. combustion tuning). Although it is well accepted that combustion tuning will generally improve efficiency and emissions of an ''out of tune'' boiler, it is not as well understood what benefits can be derived through active multiburner measurement and control systems in boiler that has coarse level controls. The approach used here was to utilize existing baseline furnace models that have been constructed using Reaction Engineering International's (REI) computational fluid dynamics (CFD) software. Using CFD analyses provides the ability to carry out a carefully controlled virtual experiment to characterize the sensitivity of NOx emissions, unburned carbon (UBC), furnace exit CO (FECO), furnace exit temperature (FEGT), and waterwall deposition to burner air and fuel flow rates. The Electric Power Research Institute (EPRI) provided co-funding for this program, and instrument and controls experts from EPRI's Instrument and Controls (I&C) Center have been active participants in this project. CFD simulations were completed for five coal fired boilers as planned: (1) 150 MW wall fired, (2) 500 MW opposed wall fired, (3) 600 MW T-Fired, (4) 330 MW cyclone-fired, and (5) 200 MW T-Fired Twin Furnace. In all cases, the unit selections were made in order to represent units that were descriptive of the utility industry as a whole. For each unit, between 25 and 44 furnace simulations were completed in order to evaluate impacts of burner to burner variations in: (1) coal and primary air flow rate, and (2) secondary air flow

  14. Status of polarization control experiment at Shanghai deep ultraviolet free electron laser

    CERN Document Server

    Deng, Haixiao; Feng, Lie; Liu, Bo; Chen, Jianhui; Dai, Zhimin; Fan, Yong; Feng, Chao; He, Yongzhou; Lan, Taihe; Song, Lin; Wang, Dong; Wang, Xingtao; Wang, Zhishan; Zhang, Jidong; Zhang, Meng; Zhang, Miao; Zhao, Zhentang

    2012-01-01

    A polarization control experiment by utilizing a pair of crossed undulators has been proposed for the Shanghai deep ultraviolet free electron laser test facility. Numerical simulations indicate that, with the electromagnetic phase-shifter located between the two crossed planar undulators, fully coherent radiation with 100 nJ order pulse energy, 5 picoseconds pulse length and circular polarization degree above 90% could be generated. The physical design study and the preparation status of the experiment are presented in the paper.

  15. Vitamin D status among multiple sclerosis patients in South Khorasan: a case-control study

    Directory of Open Access Journals (Sweden)

    Masoumeh Zarezadeh

    2017-05-01

    Full Text Available Background and Aim: Observational studies have demonstrated that the risk of developing multiple sclerosis (MS is associated with vitamin D (25(OHD status. However, there is no local study regarding vitamin D status in MS patients in the South Khorasan. Therefore, present study aimed at comparing the serum levels of vitamin D between the South Khorasan MS patients and healthy subjects, and determining its association with disability in these patients. Materials and Methods: In this case-control study a total of 144 individuals (72 previously diagnosed MS cases and 72 age and sex matched healthy controls were included. Demographic characteristics and serum vitamin D levels of both groups as well as Expanded Disability Status Scale (EDSS for MS patients were assessed. The obtained data was analyzed using t-test, Mann Whitney U test, Chi-square, and Pearson's correlation coefficient test applying SPSS software. Results: There was a significant difference (P<0.0001 in vitamin D levels between the case (47.4±5.4ng/mL and the control (14.66±10.4 ng/mL groups. A direct association was found between vitamin D levels and EDSS in MS patients (P<0.0001, too. Conclusion: Surprisingly, it was found that vitamin D level was significantly higher in MS patients than the controls. There was a significant positive association between the level of vitamin D and disability status in patients with MS. The association may be due to more administration of vitamin D supplement to MS patients.

  16. Can symmetry transitions of complex fields enable 3-d control of fluid vorticity?

    Energy Technology Data Exchange (ETDEWEB)

    Martin, James E. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Solis, Kyle Jameson [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    Methods of inducing vigorous noncontact fluid flow are important to technologies involving heat and mass transfer and fluid mixing, since they eliminate the need for moving parts, pipes and seals, all of which compromise system reliability. Unfortunately, traditional noncontact flow methods are few, and have limitations of their own. We have discovered two classes of fields that can induce fluid vorticity without requiring either gravity or a thermal gradient. The first class we call Symmetry-Breaking Rational Fields. These are triaxial fields comprised of three orthogonal components, two ac and one dc. The second class is Rational Triad Fields, which differ in that all three components are alternating. In this report we quantify the induced vorticity for a wide variety of fields and consider symmetry transitions between these field types. These transitions give rise to orbiting vorticity vectors, a technology for non-contact, non-stationary fluid mixing.

  17. Fluid-Structure Interaction During Large Amplitude Sloshing and TLD Vibration Control

    Institute of Scientific and Technical Information of China (English)

    郑兆昌; 陈夫尧; 侯之超

    2003-01-01

    The arbitrary Lagrange-Eulerian (ALE) finite element method (FEM) was successfully used to analyze fluid-structure interaction with a free surface. The fluid was regarded as a convection dominated incompressible viscous with the viscous and the slip boundary conditions. Generalized variational principles were established for the problem with large amplitude sloshing due to the free fluid surface. The Newmark-β integration method with a predictor-corrector scheme was used to solve the nonlinear dynamic response of the coupled ALE-FEM equations. Numerical examples were given to analyze the effects of a tuned liquid damper (TLD) setting on the structure. The horizontal nonlinear displacement responses in time domain at the top of the structure and the fluid elevation histories along the wall were computed and compared with predictions of a simplified mass-spring system.

  18. Control and particles distribution in drilling fluids while drilling; Controle e distribuicao de particulas em fluidos de perfuracao enquanto perfurando

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Luiz Augusto dos [PETROBRAS, XX (Brazil). Dept. de Perfuracao. Div. de Fluidos de Perfuracao

    1988-12-31

    Factors contributing both directly and indirectly to formation damage are discussed, including plugging by solids disseminated in drilling fluids, filtrations, spurt loss, and cake deposition. (author) 6 refs., 12 figs., 4 tabs.

  19. Study of Fluid Flow Control in Protein Crystallization using Strong Magnetic Fields

    Science.gov (United States)

    Ramachandran, Narayanan; Leslie, Fred; Ciszak, Ewa

    2002-11-01

    An important component in biotechnology, particularly in the area of protein engineering and rational drug design is the knowledge of the precise three-dimensional molecular structure of proteins. The quality of structural information obtained from X-ray diffraction methods is directly dependent on the degree of perfection of the protein crystals. As a consequence, the growth of high quality macromolecular crystals for diffraction analyses has been the central focus for biochemists, biologists, and bioengineers. Macromolecular crystals are obtained from solutions that contain the crystallizing species in equilibrium with higher aggregates, ions, precipitants, other possible phases of the protein, foreign particles, the walls of the container, and a likely host of other impurities. By changing transport modes in general, i.e., reduction of convection and sedimentation, as is achieved in "microgravity", researchers have been able to dramatically affect the movement and distribution of macromolecules in the fluid, and thus their transport, formation of crystal nuclei, and adsorption to the crystal surface. While a limited number of high quality crystals from space flights have been obtained, as the recent National Research Council (NRC) review of the NASA microgravity crystallization program pointed out, the scientific approach and research in crystallization of proteins has been mainly empirical yielding inconclusive results. We postulate that we can reduce convection in ground-based experiments and we can understand the different aspects of convection control through the use of strong magnetic fields and field gradients. Whether this limited convection in a magnetic field will provide the environment for the growth of high quality crystals is still a matter of conjecture that our research will address. The approach exploits the variation of fluid magnetic susceptibility with concentration for this purpose and the convective damping is realized by appropriately

  20. Comparison of Five Hydrothermal Vent Fields at the Mid-Atlantic Ridge: Which Parameters Control the Differences in Fluid Geochemistry?

    Science.gov (United States)

    Schmidt, K.; Koschinsky, A.; Garbe-Schönberg, D.; Seifert, R.

    2006-12-01

    Five different high-temperature hydrothermal vent sites along the Mid-Atlantic Ridge are investigated within a special priority program funded by the German Research Foundation (SPP 1144). The sites are all located at 3000 m water depth (near the critical point of seawater). Comparing the geochemical signature of the hydrothermal fluids with respect to the individual setting, it is possible to distinguish between the major controlling parameters as they are phase separation in the supercritical region of seawater, temperature, and host rock composition. Three of the vent sites were found at 4°49'S on the MAR in a young post-eruptive basaltic setting. Two of them are characterized by strong phase separation and the highest temperatures measured so far along the MAR (up to 407°C), assuming a very shallow heat source. It is assumed, that this hydrothermal system newly formed after a big eruption event in this region. The other one, although located at a distance of maximum 2 km from the other two, emanates somewhat cooler fluids (up to 349°C), with no indications for boiling and phase separation Despite their spatial proximity and the identical basaltic host rock in which these fields are situated, the vent fields show a clearly different fluid chemistry with depletion of alkali and earth alkali elements and some trace metals in the very hot, phase separated fluids. The Logatchev field at 14°45'N is located in an ultramafic setting with outcropping peridotitic and gabbroic rocks. The chlorinity of the fluids does not clearly indicate phase separation. Compared to the non-phase separated basaltic system at 4°49'S MAR the fluids are characterized by significantly higher concentrations of hydrogen and methane due to the serpentinization reactions, lower silica and lithium concentrations and a depletion of boron. A identical chemical signature characterizes a recently discovered system at 8°18'S, the Nibelungen field. Host rock composition with both mafic and

  1. Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children.

    Science.gov (United States)

    Momen, Ali Akbar; Azizi Malamiri, Reza; Nikkhah, Ali; Jafari, Maryam; Fayezi, Abbas; Riahi, Kourosh; Maraghi, Elham

    2015-03-01

    The aim of this study was to evaluate the efficacy and safety of intramuscular midazolam in controlling convulsive status epilepticus in children, by comparing it with rectal diazepam. In this randomized trial, 100 children (50 in each group) with convulsive status epilepticus aged 1 month to 16 years were enrolled and randomly assigned into two groups to receive either 0.3 mg/kg intramuscular midazolam or 0.5 mg/kg rectal diazepam. Main outcome measure was stopping of all motor activity after drug administration. Another measures were times between patient's arrival to emergency department till drug administration, between drug administration to seizure cessation, and between patient's arrival to seizure cessation. Both medication were effective for seizure control and no significant difference was found between successful treatments after administering the medication (P = 0.061). In the midazolam group, in 96% (48/50) of cases treatment was successful and in the diazepam group, in 94% (47/50) of cases treatment was successful. Time from arrival to administering the medication was significantly shorter in midazolam group (P = 0.017). The majority of seizures in midazolam group were stopped in less than 66 s (median) compared to 130 s (median) for diazepam group, (P midazolam is not superior but may be at least as effective as rectal diazepam for controlling of status epilepticus in children. Midazolam via IM route could be one of the choices in children with convulsive status seizures who have difficult IV access. Copyright © 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  2. Control rod drop analysis by finite element method using fluid-structure interaction for a pressurized water reactor power plant

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, K.H. [Korea Atomic Energy Research Institute, Daedukdaero 1045 Dukjin-Dong, Yusong-Ku, Daejeon 305-353 (Korea, Republic of)], E-mail: khyoon@kaeri.re.kr; Kim, J.Y.; Lee, K.H.; Lee, Y.H.; Kim, H.K. [Korea Atomic Energy Research Institute, Daedukdaero 1045 Dukjin-Dong, Yusong-Ku, Daejeon 305-353 (Korea, Republic of)

    2009-10-15

    The control rod drop analysis is very important for safety analysis. For seismic and loss of coolant accident event, the control rod assemblies shall be capable of traveling from a fully withdrawn position to 90% insertion without any blockage and within specified time and displacement limits. The analysis has been executed by analytical method using in-house code. In this method, several field data are needed. These data are obtained from nuclear, thermal-hydraulic and mechanical design groups, peculiar codes, those work groups need to cooperate together. Following the enhancement of a computer and development of the multi-physics analysis code, a new method for the control rod drop analysis is proposed by finite element method. This analysis model incorporates the structure and fluid parts, termed as a fluid and structure interaction (FSI). Because a control rod is submerged inside a guide tube of a fuel assembly, the FSI boundary condition is applied. In this model, it is assumed that the fluid is incompressible laminar flow. The structures are modeled with the solid elements because there is no deformation due to the fluid flow. The analysis two-dimensional plane model is created in the analysis with considering an axi-symmetric geometry. Therefore, the proposed analysis model will be very simple and the design data from other fields will be unnecessary. The analysis results are compared with those of the in-house code, which have been used for a commercial design. After validation, it is found that the present analysis gives a useful tool in the design of the control rod and fuel assembly.

  3. Capacity, Control, or Both – Which Aspects of Working Memory Contribute to Children’s General Fluid Intelligence?

    Directory of Open Access Journals (Sweden)

    Nęcka Edward

    2016-04-01

    Full Text Available Starting from the assumption that working memory capacity is an important predictor of general fluid intelligence, we asked which aspects of working memory account for this relationship. Two theoretical stances are discussed. The first one posits that the important explanatory factor is storage capacity, roughly defined as the number of chunks possible to hold in the focus of attention. The second one claims that intelligence is explained by the efficiency of executive control, for instance, by prepotent response inhibition. We investigated 96 children at the age between 10 and 13. They completed a version of the n-back task that allows assessment of both storage capacity and inhibitory control. They also completed Raven’s Progressive Matrices as the fluid intelligence test and the Test for Creative Thinking - Drawing Production, for control purposes. We found that Raven’s scores correlated negatively with the number of unnecessary responses to irrelevant stimuli but they did not correlate with the number of signal detections. We conclude that children’s fluid intelligence depends on inhibitory control, with no relationship with storage capacity.

  4. Gravity Probe-B Spacecraft attitude control based on the dynamics of slosh wave-induced fluid stress distribution on rotating dewar container of cryogenic propellant

    Science.gov (United States)

    Hung, R. J.; Lee, C. C.; Leslie, F. W.

    1991-01-01

    The dynamical behavior of fluids, in particular the effect of surface tension on partially-filled rotating fluids, in a full-scale Gravity Probe-B Spacecraft propellant dewar tank imposed by various frequencies of gravity jitters have been investigated. Results show that fluid stress distribution exerted on the outer and inner walls of rotating dewar are closely related to the characteristics of slosh waves excited on the liquid-vapor interface in the rotating dewar tank. This can provide a set of tool for the spacecraft dynamic control leading toward the control of spacecraft unbalance caused by the uneven fluid stress distribution due to slosh wave excitations.

  5. The Current Status of Baculovirus and Their Implication for Insect Pest Control

    Directory of Open Access Journals (Sweden)

    Arman Wijonarko

    2001-07-01

    Full Text Available Baculovirus have been promoted as the promising bioinsecticides for their pest control potential for more than half a century. But only a few have been successful as biological control agent, and almost none has been proven as commercial success, or widely used for large-scale insect pest control. The bioinsecticides currently represent only a small fraction of the world pesticide market. The successful of the Bt crop marked a special achievement in the bioinsecticide market growth. How about the baculoviruses? The main hurdle for baculovirus to be developed as bioinsecticide is its poor performance compare to synthetic chemical ones, include the speed of kill, and host range. It is important to understand the nature of baculovirus, and explore the possibilities to develop new way in applying the baculovirus as bioinsecticides. Key words: current status, baculovirus, insect control

  6. Controlling Nutritional Status (CONUT) score is a prognostic marker for gastric cancer patients after curative resection.

    Science.gov (United States)

    Kuroda, Daisuke; Sawayama, Hiroshi; Kurashige, Junji; Iwatsuki, Masaaki; Eto, Tsugio; Tokunaga, Ryuma; Kitano, Yuki; Yamamura, Kensuke; Ouchi, Mayuko; Nakamura, Kenichi; Baba, Yoshifumi; Sakamoto, Yasuo; Yamashita, Yoichi; Yoshida, Naoya; Chikamoto, Akira; Baba, Hideo

    2017-06-27

    Controlling Nutritional Status (CONUT), as calculated from serum albumin, total cholesterol concentration, and total lymphocyte count, was previously shown to be useful for nutritional assessment. The current study investigated the potential use of CONUT as a prognostic marker in gastric cancer patients after curative resection. Preoperative CONUT was retrospectively calculated in 416 gastric cancer patients who underwent curative resection at Kumamoto University Hospital from 2005 to 2014. The patients were divided into two groups: CONUT-high (≥4) and CONUT-low (≤3), according to time-dependent receiver operating characteristic (ROC) analysis. The associations of CONUT with clinicopathological factors and survival were evaluated. CONUT-high patients were significantly older (p nutritional status but also for predicting long-term OS in gastric cancer patients after curative resection.

  7. Inflammatory markers in gingival crevicular fluid of periodontitis patients with type 2 diabetes mellitus according to glycemic control: A pilot study.

    Science.gov (United States)

    Longo, Priscila Larcher; Artese, Hilana Paula Carilo; Horliana, Anna Carolina Ratto Tempestini; Gomes, Giovane Hisse; Romito, Giuseppe Alexandre; Dib, Sergio Atala; Mayer, Marcia Pinto Alves

    2015-01-01

    Type 2 diabetes mellitus (T2DM) and periodontitis are inflammatory conditions with a bidirectional association. This pilot study aimed to evaluate whether T2DM and glycemic control interfere in inflammatory markers profiles in gingival crevicular fluid (GCF) in periodontitis patients. Fourteen diabetic periodontitis patients were enrolled in this study, seven with adequate glycemic control (glycated hemoglobin [HbA1c] periodontitis patients without diabetes formed the control group (P). GCF was obtained from diseased sites (probing depth >6 mm) of an entirely hemiarch, pooled and cytokines levels determined using multiplex beads immunoassay. Clinical periodontal parameters were analyzed by Mann-Whitney test and levels of cytokines by Kruskal-Wallis and Dunn's multiple comparison tests with confidence level of 95% (P periodontal pockets presented high levels of inflammatory cytokines, and there were no statistical differences between levels of interleukin-6 (IL-6), IL-8 and tumor necrosis factor-α according to presence of diabetes or percentage of HbA1c among the groups, despite groups with T2DM and periodontitis exhibit higher levels of PD. Within the limitations of this study, inflammatory mediators in GCF are dependent to the local response and do not correlate with the diabetic status.

  8. Gender and Socioeconomic Status in Relation to Weight Perception and Weight Control Behavior in Korean Adults

    Directory of Open Access Journals (Sweden)

    Hee-Kyung Joh

    2013-02-01

    Full Text Available Aim: In Korea, obesity is more prevalent among men and lower socioeconomic groups. To explain this obesity disparity, we compared weight perception and weight control behavior across gender and socioeconomic status (SES. Methods: We analyzed data from 16,260 participants aged 20 years or older in a nationally representative cross-sectional survey. SES indicators included education and income levels. Weight under-perception was defined when participants considered themselves lighter than their measured BMI status. Either no active or inappropriate weight control (i.e., trying to gain weight in obese individuals was considered to be unhealthy patterns. Multivariate prevalence ratios were calculated using log-binomial regressions. Results: Men had a higher prevalence of weight under-perception (24.5 vs. 11.9% and unhealthy patterns of weight control behavior (57 vs. 40% than women. Low education level was associated with weight under-perception (ptrend = 0.022 in men, ptrend trend trend = 0.047 in men, ptrend Conclusion: Weight perception and weight control behavior significantly varied by gender and SES. Public actions should be directed toward improving perception and behavior of high-risk populations.

  9. Blood volume-monitored regulation of ultrafiltration in fluid-overloaded hemodialysis patients: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Hecking Manfred

    2012-06-01

    Full Text Available Abstract Background Data generated with the body composition monitor (BCM, Fresenius show, based on bioimpedance technology, that chronic fluid overload in hemodialysis patients is associated with poor survival. However, removing excess fluid by lowering dry weight can be accompanied by intradialytic and postdialytic complications. Here, we aim at testing the hypothesis that, in comparison to conventional hemodialysis, blood volume-monitored regulation of ultrafiltration and dialysate conductivity (UCR and/or regulation of ultrafiltration and temperature (UTR will decrease complications when ultrafiltration volumes are systematically increased in fluid-overloaded hemodialysis patients. Methods/design BCM measurements yield results on fluid overload (in liters, relative to extracellular water (ECW. In this prospective, multicenter, triple-arm, parallel-group, crossover, randomized, controlled clinical trial, we use BCM measurements, routinely introduced in our three maintenance hemodialysis centers shortly prior to the start of the study, to recruit sixty hemodialysis patients with fluid overload (defined as ≥15% ECW. Patients are randomized 1:1:1 into UCR, UTR and conventional hemodialysis groups. BCM-determined, ‘final’ dry weight is set to normohydration weight −7% of ECW postdialysis, and reached by reducing the previous dry weight, in steps of 0.1 kg per 10 kg body weight, during 12 hemodialysis sessions (one study phase. In case of intradialytic complications, dry weight reduction is decreased, according to a prespecified algorithm. A comparison of intra- and post-dialytic complications among study groups constitutes the primary endpoint. In addition, we will assess relative weight reduction, changes in residual renal function, quality of life measures, and predialysis levels of various laboratory parameters including C-reactive protein, troponin T, and N-terminal pro-B-type natriuretic peptide, before and after the first study

  10. Liquefied Gaseous Fuels Safety and Environmental Control Assessment Program: second status report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    Volume 2 consists of 19 reports describing technical effort performed by Government Contractors in the area of LNG Safety and Environmental Control. Report topics are: simulation of LNG vapor spread and dispersion by finite element methods; modeling of negatively buoyant vapor cloud dispersion; effect of humidity on the energy budget of a liquefied natural gas (LNG) vapor cloud; LNG fire and explosion phenomena research evaluation; modeling of laminar flames in mixtures of vaporized liquefied natural gas (LNG) and air; chemical kinetics in LNG detonations; effects of cellular structure on the behavior of gaseous detonation waves under transient conditions; computer simulation of combustion and fluid dynamics in two and three dimensions; LNG release prevention and control; the feasibility of methods and systems for reducing LNG tanker fire hazards; safety assessment of gelled LNG; and a four band differential radiometer for monitoring LNG vapors.

  11. Mortality studies of machining fluid exposure in the automobile industry. V: A case-control study of pancreatic cancer.

    Science.gov (United States)

    Bardin, J A; Eisen, E A; Tolbert, P E; Hallock, M F; Hammond, S K; Woskie, S R; Smith, T J; Monson, R R

    1997-09-01

    Results are presented from a case-control study of 97 cases of pancreatic cancer nested in a cohort of workers from three automobile manufacturing plants. Risk was examined for lifetime exposure to straight, soluble, and synthetic metalworking fluids, as used in specific machining or grinding operations, as well as for constituents of the fluids. Pancreatic cancer was associated with exposure to synthetic fluids in grinding operations, with an odds ratio of 3.0 (95% CI: 1.2-7.5) among those with more than 1.4 mg/m3-years of exposure. We were unable to examine synthetic exposure in the absence of grinding because there was virtually no exposure to synthetics in machining operations in this study population. Although a disproportionately high percent of the cases were black, no black workers had any exposure to synthetic fluids, and no other measured exposure was found to be related to risk. Thus, the previously documented excess risk of pancreatic cancer among blacks in this cohort remains unexplained.

  12. Emotional Status, Perceived Control of Pain, and Pain Coping Strategies in Episodic and Chronic Cluster Headache

    Directory of Open Access Journals (Sweden)

    Dominique Valade

    2012-08-01

    Full Text Available Cluster headache (CH is a chronic syndrome characterized by excruciatingly painful attacks occurring with circadian and circannual periodicity. The objectives of the present study were, in CH patients, to determine by principal component analysis the factor structure of two instruments commonly used in clinics to evaluate pain locus of control (Cancer Locus of Control Scale–CLCS and coping strategies (Coping Strategies Questionnaire–CSQ, to examine the relationship between internal pain controllability and emotional distress, and to compare psychosocial distress and coping strategies between two subsets of patients with episodic or chronic CH. Results indicate, for CLCS, a 3-factor structure (internal controllability, medical controllability, religious controllability noticeably different in CH patients from the structure reported in patients with other painful pathologies and, for CSQ, a 5-factor structure of CSQ which did not markedly diverge from the classical structure. Perceived internal controllability of pain was strongly correlated with study measures of depression (HAD depression/anhedonia subscale, Beck Depression Inventory. Comparison between subsets of patients with episodic or chronic CH of emotional status, pain locus of control, perceived social support and coping strategies did not reveal significant differences apart for the Reinterpreting pain sensations strategy which was more often used by episodic CH patients. Observed tendencies for increased anxiety and perceived social support in patients with episodic CH, and for increased depression and more frequent use of the Ignoring pain sensations strategy in patients with chronic CH, warrant confirmation in larger groups of patients.

  13. Consensus definitions and application guidelines for control groups in cerebrospinal fluid biomarker studies in multiple sclerosis

    DEFF Research Database (Denmark)

    Teunissen, Charlotte; Menge, Til; Altintas, Ayse

    2013-01-01

    definitions and nomenclature for the following groups: healthy controls (HCs), spinal anesthesia subjects (SASs), inflammatory neurological disease controls (INDCs), peripheral inflammatory neurological disease controls (PINDCs), non-inflammatory neurological controls (NINDCs), symptomatic controls (SCs...

  14. Status of Computational Aerodynamic Modeling Tools for Aircraft Loss-of-Control

    Science.gov (United States)

    Frink, Neal T.; Murphy, Patrick C.; Atkins, Harold L.; Viken, Sally A.; Petrilli, Justin L.; Gopalarathnam, Ashok; Paul, Ryan C.

    2016-01-01

    A concerted effort has been underway over the past several years to evolve computational capabilities for modeling aircraft loss-of-control under the NASA Aviation Safety Program. A principal goal has been to develop reliable computational tools for predicting and analyzing the non-linear stability & control characteristics of aircraft near stall boundaries affecting safe flight, and for utilizing those predictions for creating augmented flight simulation models that improve pilot training. Pursuing such an ambitious task with limited resources required the forging of close collaborative relationships with a diverse body of computational aerodynamicists and flight simulation experts to leverage their respective research efforts into the creation of NASA tools to meet this goal. Considerable progress has been made and work remains to be done. This paper summarizes the status of the NASA effort to establish computational capabilities for modeling aircraft loss-of-control and offers recommendations for future work.

  15. Fluid input control in burned patients with the aid of ultrasonic arterial blood pressure monitoring.

    Science.gov (United States)

    Banssillon, V; Latarjet, J

    1975-01-01

    Arterial blood pressure is nowadays easily and reliably measured with ultrasonic equipment. It correlates well with blood volume, and may therefore be used to guide fluid infusion in burned patients. Monitoring of blood pressure, instead of application of old-fashioned recipes, helps to avoid dangerous situations of hypovolemia or overload.

  16. Computer Software for Design, Analysis and Control of Fluid Power Systems

    DEFF Research Database (Denmark)

    Conrad, Finn; Sørensen, Torben; Grahl-Madsen, Mads

    1999-01-01

    This Deliverable presents contributions from SWING's Task 2.3 Analysis of available software solutions. The Deliverable has focus on the results from this analysis having in mind the task objectives·to carry out a thorough analysis of the state-of the-art solutions for fluid power systems modelling...

  17. Fluid and electrolyte control systems in the human body: A study report

    Science.gov (United States)

    White, R. J.

    1973-01-01

    Research in the area of modeling of the fluid and electrolyte system is briefly reviewed and a model of this system, which is adequate for a basic description of the requisite physiological processes, is presented. The use of this model as an individual subsystem model and as a component of a more complete human model is discussed.

  18. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

    NARCIS (Netherlands)

    Mattsson, N.; Andreasson, U.; Persson, S.; Arai, H.; Batish, S.D.; Bernardini, S.; Bocchio-Chiavetto, L.; Blankenstein, M.A.; Carrillo, M.C.; Chalbot, S.; Coart, E.; Chiasserini, D.; Cutler, N.; Dahlfors, G.; Duller, S.; Fagan, A.M.; Forlenza, O.; Frisoni, G.B.; Galasko, D.; Galimberti, D.; Hampel, H.; Handberg, A.; Heneka, M.T.; Herskovits, A.Z.; Herukka, S.K.; Holtzman, D.M.; Humpel, C.; Hyman, B.T.; Iqbal, K.; Jucker, M.; Kaeser, S.A.; Kaiser, E.; Kapaki, E.; Kidd, D.; Klivenyi, P.; Knudsen, C.S.; Kummer, M.P.; Lui, J.; Llado, A.; Lewczuk, P.; Li, Q.X.; Martins, R.; Masters, C.; McAuliffe, J.; Mercken, M.; Moghekar, A.; Molinuevo, J.L.; Montine, T.J.; Nowatzke, W.; O'Brien, R.; Otto, M.; Paraskevas, G.P.; Parnetti, L.; Petersen, R.C.; Prvulovic, D.; Reus, H.P. de; Rissman, R.A.; Scarpini, E.; Stefani, A.; Soininen, H.; Schroder, J.; Shaw, L.M.; Skinningsrud, A.; Skrogstad, B.; Spreer, A.; Talib, L.; Teunissen, C.; Trojanowski, J.Q.; Tumani, H.; Umek, R.M.; Broeck, B. Van; Vanderstichele, H.; Vecsei, L.; Verbeek, M.M.; Windisch, M.; Zhang, Jing; Zetterberg, H.; Blennow, K.

    2011-01-01

    BACKGROUND: The cerebrospinal fluid (CSF) biomarkers amyloid beta (Abeta)-42, total-tau (T-tau), and phosphorylated-tau (P-tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, and between and within lab

  19. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

    DEFF Research Database (Denmark)

    Mattsson, Niklas; Andreasson, Ulf; Persson, Staffan

    2011-01-01

    The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ)-42, total-tau (T-tau), and phosphorylated-tau (P-tau) demonstrate good diagnostic accuracy for Alzheimer's disease (AD). However, there are large variations in biomarker measurements between studies, and between and within laboratories. The ...

  20. NASA Ares I Launch Vehicle Roll and Reaction Control Systems Design Status

    Science.gov (United States)

    Butt, Adam; Popp, Chris G.; Pitts, Hank M.; Sharp, David J.

    2009-01-01

    This paper provides an update of design status following the preliminary design review of NASA s Ares I first stage roll and upper stage reaction control systems. The Ares I launch vehicle has been chosen to return humans to the moon, mars, and beyond. It consists of a first stage five segment solid rocket booster and an upper stage liquid bi-propellant J-2X engine. Similar to many launch vehicles, the Ares I has reaction control systems used to provide the vehicle with three degrees of freedom stabilization during the mission. During launch, the first stage roll control system will provide the Ares I with the ability to counteract induced roll torque. After first stage booster separation, the upper stage reaction control system will provide the upper stage element with three degrees of freedom control as needed. Trade studies and design assessments conducted on the roll and reaction control systems include: propellant selection, thruster arrangement, pressurization system configuration, and system component trades. Since successful completion of the preliminary design review, work has progressed towards the critical design review with accomplishments made in the following areas: pressurant / propellant tank, thruster assembly, and other component configurations, as well as thruster module design, and waterhammer mitigation approach. Also, results from early development testing are discussed along with plans for upcoming system testing. This paper concludes by summarizing the process of down selecting to the current baseline configuration for the Ares I roll and reaction control systems.

  1. A distributed control system status report of the munich accelerator control

    Science.gov (United States)

    Rohrer, L.; Schnitter, H.

    1999-04-01

    A system of computers connected by a local area network (ARCNET®) controls the Munich accelerator facility. This includes ion sources, the tandem accelerator, the beam transport system, the gas handling plant, parts of experimental setup and also an ion source test bench. ARCNET is a deterministic multi-master network with arbitrary topology, using coax cables and optical fibers. Crates with single board computers and I/O-boards (analog, parallel or serial digital), dependent on the devices being controlled, are distributed all over the building. Personal computers serve as user interfaces. The LAN communication protocol is a client/server protocol. Communication language and programming language for the single board computers is Forth. The user mode drivers in the personal computers are also written in Forth. The tools for the operators are MS-Windows applications, programmed in Forth, C++ or Visual Basic. Links to MS-Office applications are available, too.

  2. Intraoperative Fluid Restriction in Pancreatic Surgery: A Double Blinded Randomised Controlled Trial.

    Directory of Open Access Journals (Sweden)

    Ganapathy van Samkar

    Full Text Available Perioperative fluid restriction in a variety of operations has shown improvement of: complications, recovery of gastrointestinal function and length of stay (LOS. We investigated effects of crystalloid fluid restriction in pancreatic surgery. Our hypothesis: enhanced recovery of gastrointestinal function.In this double-blinded randomized trial, patients scheduled to undergo pancreatoduodenectomy (PD were randomized: standard (S:10ml/kg/hr or restricted (R:5ml/kg/hr fluid protocols.gastric emptying scintigraphically assessed on postoperative day 7.In 66 randomized patients, complications and 6-year survival were analyzed. 54 patients were analyzed in intention to treat: 24 S-group and 30 R-group. 32 patients actually underwent a PD and 16 patients had a palliative gastrojejunostomy bypass operation in the full protocol analysis. The median gastric emptying time (T½ was 104 minutes (S-group, 95% confidence interval: 74-369 versus 159 minutes (R-group, 95% confidence interval: 61-204 (P = 0.893, NS. Delayed gastric emptying occurred in 10 patients in the S-group and in 13 patients in the R-group (45% and 50%, P = 0.779, NS. The primary outcome parameter, gastric emptying time, did not show a statistically significant difference between groups.A fluid regimen of 10ml/kg/hr or 5ml/kg/hr during pancreatic surgery did not lead to statistically significant differences in gastric emptying. A larger study would be needed to draw definite conclusions about fluid restriction in pancreatic surgery.ISRCTN62621488.

  3. The characteristics and development status of the control and housekeeping electronics of FRIDA

    Science.gov (United States)

    Díaz, J. J.; Flores-Meza, R.; Sánchez, Beatriz; Patrón, Jesús

    2014-07-01

    FRIDA (inFRared Imager and Dissector for the Adaptive optics system of the Gran Telescopio Canarias) is a diffraction limited instrument that will offer broad and narrow band imaging and integral field spectroscopy with low, intermediate and high spectral resolutions in the 0.9 - 2.5 μm wavelength range. FRIDA will be installed at a Nasmyth focus of GTC, behind the AO system. The characteristics and development status of the Control and Housekeeping Electronics are described in this contribution. FRIDA is a collaborative project between the IAC (Spain), UNAM (México), UCM (Spain) and the UF (Florida), lead by UNAM.

  4. Parameters Tuning Approach for Proportion Integration Differentiation Controller of Magnetorheological Fluids Brake Based on Improved Fruit Fly Optimization Algorithm

    Directory of Open Access Journals (Sweden)

    Xinhua Liu

    2017-07-01

    Full Text Available In order to improve the response performance of a proportion integration differentiation (PID controller for magnetorheological fluids (MRF brake and to reduce the braking fluctuation rate, an improved fruit fly optimization algorithm for PID controller parameters tuning of MRF brake is proposed. A data acquisition system for MRF brake is designed and the transfer function of MRF brake is identified. Moreover, an improved fruit fly optimization algorithm (IFOA through integration of PID control strategy and cloud model algorithm is proposed to design a PID controller for MRF brake. Finally, the simulation and experiment are carried out. The results show that IFOA, with a faster response output and no overshoot, is superior to the conventional PID and fruit fly optimization algorithm (FOA PID controller.

  5. Microbiological quality and quality control of purified water and ultrapure dialysis fluids for online hemodiafiltration in routine clinical practice.

    Science.gov (United States)

    Penne, E Lars; Visser, Linda; van den Dorpel, Marinus A; van der Weerd, Neelke C; Mazairac, Albert H A; van Jaarsveld, Brigit C; Koopman, Marion G; Vos, Pieter; Feith, Geert W; Kremer Hovinga, Ton K; van Hamersvelt, Henk W; Wauters, Inge M; Bots, Michiel L; Nubé, Menso J; Ter Wee, Piet M; Blankestijn, Peter J; Grooteman, Muriel P C

    2009-09-01

    During online hemodiafiltration, patients are directly infused with sterile substitution solutions to maintain fluid balance. Adequate water treatment and a well-organized quality control process are essential to provide non-pyrogenic fluids with consistent optimal quality. We sought to assess water quality, the water treatment system, and the methods for surveillance of microbiological water quality in 10 Dutch dialysis centers that routinely treat patients with hemodiafiltration. Microbiological monitoring results (micro-organisms and endotoxins) were collected over a 1-year period representing 11,258 hemodiafiltration sessions covering 97 patients. In all centers, water purification was based on a reverse osmosis module in combination with a second reverse osmosis and/or an electrodeionizer. All centers regularly and routinely monitored the microbiological purity of the dialysis water with adequate analytical methods but with variable monitoring frequency. Microbiological assessments were compliant with reference quality levels in 3923 of 3961 samples. Our study suggests that non-pyrogenic substitution fluids can be produced online for a prolonged period of time. It is likely that the current Dutch Quality of Care Guideline has contributed to high-quality water treatment and a well-organized control process.

  6. Functional status in rate- versus rhythm-control strategies for atrial fibrillation: results of the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Functional Status Substudy.

    Science.gov (United States)

    Chung, Mina K; Shemanski, Lynn; Sherman, David G; Greene, H Leon; Hogan, David B; Kellen, Joyce C; Kim, Soo G; Martin, Lisa Warsinger; Rosenberg, Yves; Wyse, D George

    2005-11-15

    The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) functional status substudy aimed to test the hypothesis that functional status is similar in rate-control and rhythm-control strategies. Randomized studies, including the AFFIRM study, have failed to demonstrate survival benefits between rate-control and rhythm-control strategies for atrial fibrillation (AF). However, AF may cause functional capacity or cognitive impairment that might justify maintenance of sinus rhythm. Investigators of the AFFIRM study enrolled 4,060 patients with AF who required long-term therapy and who were 65 years of age or older or who had another risk factor for stroke or death. New York Heart Association functional class (NYHA-FC) and Canadian Cardiovascular Society Angina Classification were assessed at initial and each follow-up visit. From 22 randomly chosen functional status substudy sites, 245 participants underwent 6-min walk tests and Mini-Mental State Examination (MMSE) at initial, two-month, and yearly visits. Patients were assigned randomly to rate-controlling drugs, allowing AF to persist, or rhythm-controlling antiarrhythmic drugs, to maintain sinus rhythm. The NYHA-FC worsened with time in both rate-control and rhythm-control groups, with no differences between groups. Presence of AF was associated with worse NYHA-FC (p Society Angina Classification or MMSE scores. Six-minute walk distance improved over time in both study arms. On average, walk distance was 94 feet greater in the rhythm-control group (adjusted p = 0.049). Modest improvement in 6-min walk distance was noted in the rhythm-control arm. Presence of AF was associated with worse NYHA-FC. No difference in cognitive function was detected.

  7. Determinants of infant nutritional status in Dabat district, North Gondar, Ethiopia: A case control study

    Science.gov (United States)

    Wubante, Amarech Asratie

    2017-01-01

    Background Malnutrition is the top cause of global burden of disease, disability and mortality among infants. Over two-thirds of deaths of children globally occur during the first year of life (infancy). Malnutrition among infants is substantially high in Ethiopia. Therefore, this study is aimed to assess determinants of infant nutritional status. Methods A community based nested case-control study was conducted from February to June 2013 in Dabat district. A total of 80 cases and 320 controls (1:4 ratios) were studied. Relevant data was extracted from the community based survey data set. Anthroplus software was used to identify cases and controls. Determinants of infant nutritional status were identified using multivariate analysis. Results Among the total of 80 cases and 320 controls, more than half (52.5%) of the cases and the controls (53.8%) were males and females, respectively. Breast Feeding (BF) was started immediately after birth in only 43.8% of the cases. Nearly 94% of the mothers of the cases had no breast feeding information as part of Ante Natal Care (ANC) follow up. Maternal age (AOR: 0.29; 95% CI: 0.11–0.76), having radio (AOR: 0.43; 95% CI: 0.22–0.82), lack of toilet facility (AOR: 2.24; 95% CI: 1.16–4.33), deprivation of colostrum (AOR: 1.76; 95% CI: 1.01–1.06) and method of complementary feeding (AOR: 2.82; 95% CI: 1.33–5.99) were associated with wasting. Conclusions This study has found that inappropriate infant feeding; nutritional information gap and lack of toilet facility as significant predictors of malnutrition. Hence, joint interventions, including counseling of mothers about benefits of colostrum feeding and use of appropriate feeding method, toilet utilization and mass media such as radio possession, are needed to address the problem in Dabat district. PMID:28346497

  8. The development of a positive isolation disconnect. [for fluid Shuttle Environmental Control/Life Support subsystems maintenance

    Science.gov (United States)

    Rosener, A. A.

    1976-01-01

    Conceptual design and developmental testing were conducted to determine the feasibility of a highly reliable, positive isolation disconnect (PID) for potential inflight maintenance of Shuttle environmental control/life support system subsystems. The PID design consists of two coupled valves, each capable of fluid isolation through the use of individually operated opposing poppets. An integral level clamping mechanism couples the two valves and locks the bodies together. The coupling lever is locked in position by turning the valve stems that have foolproof caps. The stem shaft has an integral cam that turns inside a yoke to open the poppet to permit fluid flow. Results of 5000 life cycle tests, hydraulic lock test, leakage tests, and pressure drop tests are included.

  9. Inflammatory markers in gingival crevicular fluid of periodontitis patients with type 2 diabetes mellitus according to glycemic control: A pilot study

    Directory of Open Access Journals (Sweden)

    Priscila Larcher Longo

    2015-01-01

    Full Text Available Background: Type 2 diabetes mellitus (T2DM and periodontitis are inflammatory conditions with a bidirectional association. This pilot study aimed to evaluate whether T2DM and glycemic control interfere in inflammatory markers profiles in gingival crevicular fluid (GCF in periodontitis patients. Materials and Methods: Fourteen diabetic periodontitis patients were enrolled in this study, seven with adequate glycemic control (glycated hemoglobin [HbA1c] 6 mm of an entirely hemiarch, pooled and cytokines levels determined using multiplex beads immunoassay. Clinical periodontal parameters were analyzed by Mann-Whitney test and levels of cytokines by Kruskal-Wallis and Dunn′s multiple comparison tests with confidence level of 95% (P < 0.05. Results: Cytokines profile of GCF obtained from deep periodontal pockets presented high levels of inflammatory cytokines, and there were no statistical differences between levels of interleukin-6 (IL-6, IL-8 and tumor necrosis factor-α according to presence of diabetes or percentage of HbA1c among the groups, despite groups with T2DM and periodontitis exhibit higher levels of PD. Conclusion: Within the limitations of this study, inflammatory mediators in GCF are dependent to the local response and do not correlate with the diabetic status.

  10. Polymorphisms in the control region of mitochondrial DNA associated with elite Japanese athlete status.

    Science.gov (United States)

    Mikami, E; Fuku, N; Takahashi, H; Ohiwa, N; Pitsiladis, Y P; Higuchi, M; Kawahara, T; Tanaka, M

    2013-10-01

    The control region of mitochondrial DNA (mtDNA) contains the main regulatory elements for mtDNA replication and transcription. Certain polymorphisms in this region would, therefore, contribute to elite athletic performance, because mitochondrial function is one of determinants of physical performance. The present study was undertaken to examine the effect of polymorphisms in this region on elite athlete status by sequencing the mtDNA control region. Subjects comprised 185 elite Japanese athletes who had represented Japan at international competitions (i.e., 100 endurance/middle-power athletes: EMA; 85 sprint/power athletes: SPA), and 672 Japanese controls (CON). The mtDNA control region was analyzed by direct sequencing. Frequency differences of polymorphisms (minor allele frequency ≥ 0.05) in the mtDNA control region between EMA, SPA, and CON were examined. EMA displayed excess of three polymorphisms [m.152T>C, m.514(CA)n repeat (n ≥ 5), and poly-C stretch at m.568-573 (C ≥ 7)] compared with CON. On the other hand, SPA showed greater frequency of the m.204T>C polymorphism compared with CON. In addition, none of the SPA had m.16278C>T polymorphism, whereas the frequencies of this polymorphism in CON and EMA were 8.3% and 10.0%, respectively. These findings imply that several polymorphisms detected in the control region of mtDNA may influence physical performance probably in a functional manner.

  11. Control of electro-rheological fluid-based torque generation components for use in active rehabilitation devices

    Science.gov (United States)

    Nikitczuk, Jason; Weinberg, Brian; Mavroidis, Constantinos

    2006-03-01

    In this paper we present the design and control algorithms for novel electro-rheological fluid based torque generation elements that will be used to drive the joint of a new type of portable and controllable Active Knee Rehabilitation Orthotic Device (AKROD) for gait retraining in stroke patients. The AKROD is composed of straps and rigid components for attachment to the leg, with a central hinge mechanism where a gear system is connected. The key features of AKROD include: a compact, lightweight design with highly tunable torque capabilities through a variable damper component, full portability with on board power, control circuitry, and sensors (encoder and torque), and real-time capabilities for closed loop computer control for optimizing gait retraining. The variable damper component is achieved through an electro-rheological fluid (ERF) element that connects to the output of the gear system. Using the electrically controlled rheological properties of ERFs, compact brakes capable of supplying high resistive and controllable torques, are developed. A preliminary prototype for AKROD v.2 has been developed and tested in our laboratory. AKROD's v.2 ERF resistive actuator was tested in laboratory experiments using our custom made ERF Testing Apparatus (ETA). ETA provides a computer controlled environment to test ERF brakes and actuators in various conditions and scenarios including emulating the interaction between human muscles involved with the knee and AKROD's ERF actuators / brakes. In our preliminary results, AKROD's ERF resistive actuator was tested in closed loop torque control experiments. A hybrid (non-linear, adaptive) Proportional-Integral (PI) torque controller was implemented to achieve this goal.

  12. Fluid loading responsiveness

    NARCIS (Netherlands)

    Geerts, Bart

    2011-01-01

    Patients in the intensive care unit (ICU) and in the peri-operative phase are dependent on physicians and nurses for their fluid intake. Volume status optimization is required to maximize oxygen delivery to vital organs. Unnecessary fluid administration can, however, lead to general and pulmonary

  13. Fluid loading responsiveness

    NARCIS (Netherlands)

    Geerts, Bart

    2011-01-01

    Patients in the intensive care unit (ICU) and in the peri-operative phase are dependent on physicians and nurses for their fluid intake. Volume status optimization is required to maximize oxygen delivery to vital organs. Unnecessary fluid administration can, however, lead to general and pulmonary oe

  14. Fluid loading responsiveness

    NARCIS (Netherlands)

    Geerts, Bart

    2011-01-01

    Patients in the intensive care unit (ICU) and in the peri-operative phase are dependent on physicians and nurses for their fluid intake. Volume status optimization is required to maximize oxygen delivery to vital organs. Unnecessary fluid administration can, however, lead to general and pulmonary oe

  15. Flywheel energy storage control system with the system operating status control via the Internet

    Directory of Open Access Journals (Sweden)

    Baszyński Marcin

    2014-09-01

    Full Text Available Modern electronics systems consist of not only with the power electronics converters, but also with the friendly user interface which allow you to read the operating parameters and change them. The simplest solution of the user interface is to use alphanumeric display which displays information about the state of the converter. With a few additional buttons you can change the settings. This solution is simple, inexpensive but allows only local control (within walking distance from the system and the number of displayed information is low. You can create extensive menu, but it causes problems with access to information. This paper presents the example of a rotating energy storage universal solution which is lack of the above mentioned disadvantages

  16. A kinetic control of the heliospheric interface hydrodynamics of charge-exchanging fluids

    CERN Document Server

    Fahr, H J

    2004-01-01

    It is well known that the Solar System is presently moving through a partially ionized local interstellar medium. This gives rise to a counter-flow situation requiring a consistent description of behaviour of the two fluids -- ions and neutral atoms -- which are dynamically coupled by mutual charge exchange processes. Solutions to this problem have been offered in the literature, all relying on the assumption that the proton fluid, even under evidently nonequilibrium conditions, can be expected to stay in a highly-relaxated distribution function given by mono-Maxwellians shifted by the local proton bulk velocity. Here we check the validity of this assumption, calculating on the basis of a Boltzmann-kinetic approach the actually occurring deviations. As we show, especially for low degrees of ionization, $\\xi \\le 0.3$, both the H-atoms and protons involved do generate in the heliospheric interface clearly pronounced deviations from shifted Maxwellians with asymmetrically shaped distribution functions giving ris...

  17. New shale shaker as a primary unit for controlling solids in drilling fluids

    Energy Technology Data Exchange (ETDEWEB)

    Lange, A.; Pahlke, K.; Schillinger, H.

    1988-04-01

    The purpose of the shale shaker is the primary separation of the cuttings from the drilling fluid at comparatively low cost; it thus exerts a substantial influence on the equipment installed downstream. Nevertheless, further development of this vital machine has been neglected for many years. Relatively coarse-meshed vibrating screens have been employed for decades on the shale shakers available on drilling rigs. A new shale shaker is described, and experience hitherto gained in the field is discussed.

  18. Photostructurized electrochemical biosensors for bioreactor control and measurement in body fluids.

    Science.gov (United States)

    Lobmaier, C; Schalkhammer, T; Hawa, G; Ecker, B; Pittner, F

    1995-01-01

    This article details a new type of biosensor for the simultaneous analysis of glucose, glutamate and glutamine in complex biological fluids like fermentation broths and blood. Simultaneous analysis was made possible by the application of different enzyme layers onto different electrodes of one photostructurized sensor. Photostructuring was done by means of a new developed photopolymer. Preparation of the photopolymer and the enzyme layers as well as the characterization of the sensors thus constructed with respect to linearity, response time and sensitivity are described.

  19. Computer Software for Design, Analysis and Control of Fluid Power Systems

    DEFF Research Database (Denmark)

    Conrad, Finn; Sørensen, Torben; Grahl-Madsen, Mads

    1999-01-01

    This Deliverable presents contributions from SWING's Task 2.3 Analysis of available software solutions. The Deliverable has focus on the results from this analysis having in mind the task objectives·to carry out a thorough analysis of the state-of the-art solutions for fluid power systems modelli...... and modelling IT tools in the implementation planning (WP3) and pilot implementation (WP4), in particular training programme for key people in the individual SME and/or cluster....

  20. Characterization and Testing of an Electrorheological Fluid Valve for Control of ERF Actuators

    OpenAIRE

    Quang-Anh Nguyen; Steven Jens Jorgensen; Joseph Ho; Luis Sentis

    2015-01-01

    Previous studies of electrorheological fluids (ERFs) were motivated by brake, clutch, damping, haptic and resistive applications, but never motivated towards developing an ERF based-hydraulic rotary actuator. One design to make such an actuator is to use ERF-based valves. To fully understand the performance of such an actuator, it is imperative to study ERF valves. For this reason, this paper presents a summary of design considerations for creating ERF-based actuators, an ERF-based valve desi...

  1. Morphine and Codeine in Oral Fluid after Controlled Poppy Seed Administration

    OpenAIRE

    Concheiro, Marta; Newmeyer, Matthew N.; da Costa, Jose Luiz; Flegel, Ron; Gorelick, David A.; Huestis, Marilyn A.

    2014-01-01

    Opiates are an important drug class in drug testing programs. Ingestion of poppy seeds containing morphine and codeine can yield positive opiate tests and mislead result interpretation in forensic and clinical settings. Multiple publications evaluated urine opiate concentrations following poppy seed ingestion, but only 2 addressed oral fluid (OF) results; neither provided the ingested morphine and codeine dosage. We administered two 45g raw poppy seed doses, each containing 15.7mg morphine an...

  2. Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study

    Directory of Open Access Journals (Sweden)

    Erika P. S. Freitas

    2017-02-01

    Full Text Available Metabolic syndrome (MS involves pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic factors in patients with MS. Our case control study included 88 patients with MS and 37 controls. We performed clinical and anthropometric assessments and obtained lipid, glycemic, and inflammatory profiles. We also evaluated zinc intake, plasma zinc, erythrocyte zinc, and 24-h urinary zinc excretion. The average zinc intake was significantly lower in the MS group (p < 0.001. Regression models indicated no significant differences in plasma zinc concentration (all p > 0.05 between the two groups. We found significantly higher erythrocyte zinc concentration in the MS group (p < 0.001 independent from co-variable adjustments. Twenty-four hour urinary zinc excretion was significantly higher in the MS group (p = 0.008, and adjustments for age and sex explained 21% of the difference (R2 = 0.21, p < 0.001. There were significant associations between zincuria and fasting blood glucose concentration (r = 0.479, waist circumference (r = 0.253, triglyceride concentration (r = 0.360, glycated hemoglobin concentration (r = 0.250, homeostatic model assessment—insulin resistance (r = 0.223, and high-sensitivity C-reactive protein concentration (r = 0.427 (all p < 0.05 in the MS group. Patients with MS had alterations in zinc metabolism mainly characterized by an increase in erythrocyte zinc and higher zincuria.

  3. Status of combustion-modification technology for utility-boiler NO/sub x/ control

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-01

    This report documents significant developments in the subject area of combustion modifications as applied to coal-fired utility boilers. The primary emphasis is on the status of NO/sub x/ control technology, but related topics, such as boiler corrosion and hazardous emissions during modified-combustion operation, are also discussed. This report is intended as a complement to the 1977 Assessment of NO/sub x/ Control Technology for Coal-Fired Utility Boilers (ANL/ECT-3, Appendix D). A synopsis of recent NO/sub x/ field-test programs undertaken by the U.S. Environmental Protection Agency (EPA) and the Electric Power Research Institute (EPRI) is presented along with a status report on the major boiler manufacturers' low-NO/sub x/ burner/boiler development efforts. Because of concerns that low-NO/sub x/ operating modes may increase boiler-tubewall corrosion and increase polycyclic-organic-matter (POM) and SO/sub 3/ emissions, discussions of recent test programs and analytical studies on these topics are also included.

  4. Zinc Status Biomarkers and Cardiometabolic Risk Factors in Metabolic Syndrome: A Case Control Study

    Science.gov (United States)

    Freitas, Erika P. S.; Cunha, Aline T. O.; Aquino, Sephora L. S.; Pedrosa, Lucia F. C.; Lima, Severina C. V. C.; Lima, Josivan G.; Almeida, Maria G.; Sena-Evangelista, Karine C. M.

    2017-01-01

    Metabolic syndrome (MS) involves pathophysiological alterations that might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic factors in patients with MS. Our case control study included 88 patients with MS and 37 controls. We performed clinical and anthropometric assessments and obtained lipid, glycemic, and inflammatory profiles. We also evaluated zinc intake, plasma zinc, erythrocyte zinc, and 24-h urinary zinc excretion. The average zinc intake was significantly lower in the MS group (p 0.05) between the two groups. We found significantly higher erythrocyte zinc concentration in the MS group (p waist circumference (r = 0.253), triglyceride concentration (r = 0.360), glycated hemoglobin concentration (r = 0.250), homeostatic model assessment—insulin resistance (r = 0.223), and high-sensitivity C-reactive protein concentration (r = 0.427) (all p < 0.05) in the MS group. Patients with MS had alterations in zinc metabolism mainly characterized by an increase in erythrocyte zinc and higher zincuria. PMID:28241426

  5. Dietary and biochemical indices of nutritional status in male athletes and controls.

    Science.gov (United States)

    Fogelholm, G M; Himberg, J J; Alopaeus, K; Gref, C G; Laakso, J T; Lehto, J J; Mussalo-Rauhamaa, H

    1992-04-01

    To determine whether physical exercise affects biochemical indices of nutritional status, we compared four groups of male athletes (total n = 427) with two control groups (n = 150). Data about their nutrient intake for 1 month were obtained from a 122-item food frequency questionnaire. An estimate for leisure energy expenditure (EE) was calculated from a 15-item physical activity questionnaire. Athletes were grouped according to their EE (ModEE and HighEE athletes) and weight (light = less than 75 kg; heavy = greater than or equal to 75 kg), and controls according to their weight. Mean energy intake in ModEE and HighEE athletes was 2805-3260 kcal/day. Leisure EE significantly (p less than 0.0001) affected energy and nutrient intakes. Energy, riboflavin and calcium intakes were also higher in heavy subjects (P = 0.0006-0.03). The estimated percentage of subjects with deficient dietary intakes, calculated from probability analyses, was 0-6, depending on group and nutrient. Erythrocyte transketolase activation coefficient (E-TKAC) was highest in controls (1.17 +/- 0.0008; p = 0.001). Serum magnesium was highest (p = 0.01) in ModEE athletes (0.85 +/- 0.006 mmol/L). No intergroup differences were found for plasma ascorbic acid, serum zinc or serum ferritin concentration, whereas blood hemoglobin was lowest (p less than 0.001) in HighEE athletes (149 +/- 0.5 g/L). Ten percent of the control subjects had E-TKAC greater than 1.24. Percentage of other values outside reference range was 0-4, depending on group and indicator. Since lowered blood hemoglobin concentration can be explained by hemodilution, we conclude that sports training did not have a negative effect on biochemical indices of thiamin, vitamin C, magnesium, iron, or zinc status in Finnish male athletes.

  6. The effect of a negative energy balance status on β-carotene availability in serum and follicular fluid of nonlactating dairy cows.

    Science.gov (United States)

    De Bie, J; Langbeen, A; Verlaet, A A J; Florizoone, F; Immig, I; Hermans, N; Fransen, E; Bols, P E J; Leroy, J L M R

    2016-07-01

    Maternal metabolic pressure due to a cow's negative energy balance (NEB) has a negative effect on oocyte quality as a result of increased oxidative stress. In this study, we hypothesized that a NEB status may negatively affect the availability of β-carotene (bC, an antioxidant) in the micro-environment of the oocyte or follicular fluid (FF) and that daily bC supplementation can increase bC availability. We aimed to (1) determine the effect of a nutritionally induced NEB on bC concentrations in serum and FF as well as on the presence of bC metabolites, oxidative stress levels, and follicular growth in a nonlactating dairy cow model, and (2) investigate how this effect could be altered by dietary bC supplementation. Six multiparous nonlactating Holstein Friesian cows were subjected to 4 consecutive dietary treatments, 28 d each: (1) 1.2 × maintenance (M) or positive energy balance (PEB) without bC supplement (PEB-bC), (2) 1.2 × M with daily supplement of 2,000mg of bC comparable to the level of bC intake at grazing (PEB+bC), (3) 0.6 × M with 2,000mg of bC (NEB+bC), and (4) 0.6 × M (NEB-bC). At the end of each treatment, estrous cycles were synchronized and blood and FF of the largest follicle were sampled and analyzed for bC, retinol, α-tocopherol, free fatty acids, estradiol, and progesterone. Serum cholesterol, triglycerides, urea, insulin growth factor 1, growth hormone, total antioxidant status (TAS), and red blood cell glutathione (GSH) concentrations were determined as well. All cows lost body weight during both energy restriction periods and showed increased serum free fatty acid concentrations, illustrating a NEB. A dietary induced NEB reduced FF bC, but not plasma bC or plasma and FF retinol concentrations. However, bC and retinol concentrations drastically increased in both fluid compartments after bC supplementation. Follicular diameter was increased in supplemented PEB cows. Energy restriction reduced the TAS and red blood cell GSH, whereas daily b

  7. Oral status in patients with early rheumatoid arthritis: a prospective, case-control study.

    Science.gov (United States)

    Wolff, Björn; Berger, Timo; Frese, Cornelia; Max, Regina; Blank, Norbert; Lorenz, Hanns-Martin; Wolff, Diana

    2014-03-01

    Patients with RA suffer from a higher risk of periodontal attachment loss and increased oral inflammation. We hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced RA. The primary objective of the present study was to determine whether a loss of alveolar bone can be detected in RA patients during the early course of the disease. In this cross-sectional, epidemiological case-control study, 22 patients with early RA (ERA) were compared with 22 matched healthy controls. Oral and periodontal status, clinical activity, and socio-demographic parameters were determined. Oral microbiota were analysed using real-time quantitative PCR specific for leading oral pathogens. More advanced forms of periodontitis were found in ERA patients compared with controls. ERA patients had a greater number of missing teeth [ERA 5.7 (s.d. 5.0), controls 1.9 (s.d. 1.0), P = 0.002], deeper periodontal pockets [clinical attachment level: ERA 3.4 (s.d. 0.5 mm), controls 2.7 (s.d. 0.3 mm), P periodontal attachment and alveolar bone can be detected in patients with ERA, therefore we propose that the consulting rheumatologists inform the patients that they have a higher risk of periodontal disease. It would be beneficial if these patients were referred directly for intensive dental care.

  8. A randomized, double-blinded, controlled trial of the effects of fluid rate and/or presence of dextrose in intravenous fluids on the labor course of nulliparas.

    Science.gov (United States)

    Fong, Alex; Serra, Allison E; Caballero, Deysi; Garite, Thomas J; Shrivastava, Vineet K

    2017-08-01

    Prolonged labor has been demonstrated to increase adverse maternal and neonatal outcome. A practice that may decrease the risk of prolonged labor is the modification of fluid intake during labor. Several studies demonstrated that increased hydration in labor as well as addition of dextrose-containing fluids may be associated with a decrease in length of labor. The purpose of our study was to characterize whether high-dose intravenous fluids, standard-dose fluids with dextrose, or high-dose fluids with dextrose show a difference in the duration of labor in nulliparas. Nulliparous subjects with singletons who presented in active labor were randomized to 1 of 3 groups of intravenous fluids: 250 mL/h of normal saline, 125 mL/h of 5% dextrose in normal saline, or 250 mL/h of 2.5% dextrose in normal saline. The primary outcome was total length of labor from initiation of intravenous fluid in vaginally delivered subjects. Secondary outcomes included cesarean delivery rate and length of second stage of labor, among other maternal and neonatal outcomes. In all, 274 subjects who met inclusion criteria were enrolled. There were no differences in baseline characteristics among the 3 groups. There was no difference in the primary outcome of total length of labor in vaginally delivered subjects among the 3 groups. First stage of labor duration, second stage of labor duration, and cesarean delivery rates were also equivalent. There were no differences identified in other secondary outcomes including clinical chorioamnionitis, postpartum hemorrhage, blood loss, Apgar scores, or neonatal intensive care admission. There is no difference in length of labor or delivery outcomes when comparing high-dose intravenous fluids, addition of dextrose, or use of high-dose intravenous fluids with dextrose in nulliparous women who present in active labor. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. [The Experience of Fluid Management in Hemodialysis Patients].

    Science.gov (United States)

    Kim, Yoonsoo; Kim, Miyoung

    2015-10-01

    The purpose of this study was to explore the experience of fluid management in hemodialysis patients by describing how they manage fluid intake and what affects fluid management. Purposive sampling yielded 11 patients who have received hemodialysis for one year or longer in one general hospital. Data were collected through in-depth interviews and analysed using Giorgi's phenomenological method. Data collection and analysis were performed concurrently. The findings regarding how hemodialysis patients manage fluid intake were classified into four constituents: 'recognizing the need for fluid control', 'observing the status of fluid accumulation', 'controlling fluid intake and output', 'getting used to fluid management'. The factors that affect fluid management of hemodialysis patients were revealed as 'willpower', 'change in the mindset', 'support system', and 'emotional state'. The study results show that hemodialysis patients manage fluid intake through food and exercise as well as interpersonal relationships. These findings suggest that strategies in the development of nursing interventions for hemodialysis patients should be directed at assisting them in familiarization with fluid management based on an understanding of their sociocultural contexts.

  10. Estimation of the probability of exposure to machining fluids in a population-based case-control study.

    Science.gov (United States)

    Park, Dong-Uk; Colt, Joanne S; Baris, Dalsu; Schwenn, Molly; Karagas, Margaret R; Armenti, Karla R; Johnson, Alison; Silverman, Debra T; Stewart, Patricia A

    2014-01-01

    We describe an approach for estimating the probability that study subjects were exposed to metalworking fluids (MWFs) in a population-based case-control study of bladder cancer. Study subject reports on the frequency of machining and use of specific MWFs (straight, soluble, and synthetic/semi-synthetic) were used to estimate exposure probability when available. Those reports also were used to develop estimates for job groups, which were then applied to jobs without MWF reports. Estimates using both cases and controls and controls only were developed. The prevalence of machining varied substantially across job groups (0.1->0.9%), with the greatest percentage of jobs that machined being reported by machinists and tool and die workers. Reports of straight and soluble MWF use were fairly consistent across job groups (generally 50-70%). Synthetic MWF use was lower (13-45%). There was little difference in reports by cases and controls vs. controls only. Approximately, 1% of the entire study population was assessed as definitely exposed to straight or soluble fluids in contrast to 0.2% definitely exposed to synthetic/semi-synthetics. A comparison between the reported use of the MWFs and U.S. production levels found high correlations (r generally >0.7). Overall, the method described here is likely to have provided a systematic and reliable ranking that better reflects the variability of exposure to three types of MWFs than approaches applied in the past. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resources: a list of keywords in the occupational histories that were used to link study subjects to the metalworking fluids (MWFs) modules; recommendations from the literature on selection of MWFs based on type of machining operation, the metal being machined and decade; popular additives to MWFs; the number and proportion of controls who

  11. Effect of Thermal Buoyancy on Fluid Flow and Inclusion Motion in Tundish without Flow Control Devices--Part Ⅰ: Fluid Flow

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li-feng; ZHI Jian-jun; MOU Ji-ning; CUI Jian

    2005-01-01

    The κ-ε two-equation model is used to simulate the fluid flow in the continuous casting tundish coupling with the effect of thermal buoyancy. The natural convection induced by the thermal buoyancy generates an upward flow pattern especially at the outlet zone, and has little effect on the fluid flow in the inlet zone. The maximum viscosity is 700 times larger than the laminar viscosity, which indicates the strong turbulent flow in the tundish. The maximum temperature difference in the whole tundish is 8.2 K. The temperature near the stopper rod and the short wall is obviously lower than that in the inlet zone. The existence of the stopper rod has a big effect on the fluid flow entering the SEN and the mold. All the characteristics of the tundish geometry should be considered to accurately simulate the fluid flow in the tundish.

  12. Effects of working memory and attentional control training and their transfer onto fluid intelligence in early and late adulthood

    Directory of Open Access Journals (Sweden)

    Ludmiła Zając-Lamparska

    2016-01-01

    Full Text Available Background The interest in the possibility of improving cognitive functioning through training of basic cognitive processes is growing. This possibility is of particular importance for older adults, whose cognitive functions are weakened, and who may need cognitive rehabilitation. However, improvement of the performance in the tasks being trained is not the only goal of basic cognitive processes training. Far transfer, onto tasks different to the ones trained, and engaging other (usually complex processes, including fluid intelligence, is an important goal of such training. Yet, meta-analyses suggest that results of studies on the far transfer phenomenon vary, and are not conclusive. Participants and procedure One hundred and eighty healthy volunteers took part in this study. They were divided into groups: Experimental 1 (working memory training, Experimental 2 (attentional control training and Control (non-contact. Each of these groups included participants from the two age subgroups: early and late adulthood. Training involved 7 appointments and lasted for about 4 weeks. Additional measurements, including an assessment of fluid intelligence, were performed on each group at baseline, and at the end of training. Results Our results suggest that (a the training of basic cognitive processes in adults leads to an improvement in the correctness, but not the speed, at which tasks are performed, (b there is a transfer effect onto fluid intelligence, but this effect is weak, and (c the effects of basic cognitive process training depend on the kind of trained tasks, age of participants and the interactions between these two factors: working memory training is equally as effective in both age groups, whereas training of attentional control is particularly effective among older individuals, and has limited efficacy for young adults. Conclusions Finally, one can conclude that the effectiveness of basic cognitive function training is limited. However, it

  13. Effects of working memory and attentional control training and their transfer onto fluid intelligence in early and late adulthood

    Directory of Open Access Journals (Sweden)

    Ludmiła Zając-Lamparska

    2016-01-01

    Full Text Available Background The interest in the possibility of improving cognitive functioning through training of basic cognitive processes is growing. This possibility is of particular importance for older adults, whose cognitive functions are weakened, and who may need cognitive rehabilitation. However, improvement of the performance in the tasks being trained is not the only goal of basic cognitive processes training. Far transfer, onto tasks different to the ones trained, and engaging other (usually complex processes, including fluid intelligence, is an important goal of such training. Yet, meta-analyses suggest that results of studies on the far transfer phenomenon vary, and are not conclusive. Participants and procedure One hundred and eighty healthy volunteers took part in this study. They were divided into groups: Experimental 1 (working memory training, Experimental 2 (attentional control training and Control (non-contact. Each of these groups included participants from the two age subgroups: early and late adulthood. Training involved 7 appointments and lasted for about 4 weeks. Additional measurements, including an assessment of fluid intelligence, were performed on each group at baseline, and at the end of training. Results Our results suggest that (a the training of basic cognitive processes in adults leads to an improvement in the correctness, but not the speed, at which tasks are performed, (b there is a transfer effect onto fluid intelligence, but this effect is weak, and (c the effects of basic cognitive process training depend on the kind of trained tasks, age of participants and the interactions between these two factors: working memory training is equally as effective in both age groups, whereas training of attentional control is particularly effective among older individuals, and has limited efficacy for young adults. Conclusions Finally, one can conclude that the effectiveness of basic cognitive function training is limited. However, it

  14. A Strategy for Passive Control of Natural Roll-Waves in Power-Law Fluids through Inlet Boundary Conditions

    Directory of Open Access Journals (Sweden)

    C. Di Cristo

    2017-01-01

    Full Text Available The paper investigates the influence of the inlet boundary condition on the spatial evolution of natural roll-waves in a power-law fluid flowing in steep slope channels. The analysis is carried out numerically, by solving the von Kármán depth-integrated mass and momentum conservation equations, in the long-wave approximation. A second-order accurate scheme is adopted and a small random white-noise is superposed to the discharge at the channel inlet to generate the natural roll-waves train. Both shear-thinning and shear-thickening power-law fluids are investigated, considering uniform, accelerated and decelerated hypercritical profiles as the unperturbed condition. Independently of the unperturbed profile and of the fluid rheology, numerical simulations clearly enlighten the presence of coalescence, coarsening and overtaking processes, as experimentally observed. All the considered statistical parameters indicate that the natural roll-waves spatial evolution is strongly affected by the unperturbed profile. Compared with the uniform condition, at the beginning of roll-waves development an accelerated profile reduces the growth of the roll-waves with a downstream shift of the non-linear wave interaction. The opposite behavior is observed if the roll wave train develops over a decelerated profile. The comparison with the theoretical outcomes of the linearized near wave-front analysis allows the interpretation of this result in terms of stability of the base flow. It is shown that once the coarsening process starts to take place, the roll-waves spatial growth rate is independent of the unperturbed profile. Present results suggest that an appropriate selection of the flow depth at the channel inlet may contribute to control, either enhancing or inhibiting, the formation of a roll-waves train in power-law fluids.

  15. [Status of prevalence, awareness, treatment and controll on hypertension among adults in 10 regions, China].

    Science.gov (United States)

    Guo, Jie; Yu, Canqing; Lyu, Jun; Guo, Yu; Bian, Zheng; Zhou, Huiyan; Tan, Yunlong; Pei, Pei; Chen, Junshi; Chen, Zhengming; Li, Liming

    2016-04-01

    To describe the status of prevalence, awareness, treatment, and control of hypertension among half a million adults in 10 regions under the China Kadoorie Biobank (CKB) cohort. The baseline survey of CKB was performed in 10 areas across China during 2004-2008, included 512 891 adults aged from 30 to 79 years. Regional differences of prevalence, awareness, treatment and control of hypertension were compared after adjustment for age and/or sex. The overall prevalence of hypertension from the CKB was 35.2% (180 612/512 891), with the highest as 44.4% in Zhejiang and the lowest as 22.0% in Haikou. Prevalence in the rural areas (35.1%) was higher than that in the urban areas (32.1%), with statistical significance (Phypertension, 59 703 (33.1%) were aware of hypertension, 65 172 (36.1%) were receiving anti-hypertension treatment and 22 329 (12.4%) were under controll. However, only a small part of those receiving treatment were under controll (30.5%, 19 884/65 172) in this study. The control of hypertension and of those receiving treatment were higher in Suzhou for males (17.4%, 39.1%), while were higher in Liuzhou for females (23.5%, 42.6%) than those in other regions. Participants under the CKB presented relatively high prevalence of hypertension, but lower rates on awareness, treatment and control of hypertension. Distribution of awareness, treatment, and control of hypertension varied greatly among the ten areas, under the CKB.

  16. Extended daily dialysis in acute kidney injury patients: metabolic and fluid control and risk factors for death.

    Directory of Open Access Journals (Sweden)

    Daniela Ponce

    Full Text Available Intermittent hemodialysis (IHD and continuous renal replacement therapies (CRRT are used as Acute Kidney Injury (AKI therapy and have certain advantages and disadvantages. Extended daily dialysis (EDD has emerged as an alternative to CRRT in the management of hemodynamically unstable AKI patients, mainly in developed countries.We hypothesized that EDD is a safe option for AKI treatment and aimed to describe metabolic and fluid control of AKI patients undergoing EDD and identify complications and risk factors associated with death.This is an observational and retrospective study describing introduction of EDD at our institution. A total of 231 hemodynamically unstable AKI patients (noradrenalin dose between 0.3 and 1.0 ucg/kg/min were assigned to 1367 EDD session. EDD consisted of 6-8 h of HD 6 days a week, with blood flow of 200 ml/min, dialysate flows of 300 ml/min.Mean age was 60.6±15.8 years, 97.4% of patients were in the intensive care unit, and sepsis was the main etiology of AKI (76.2. BUN and creatinine levels stabilized after four sessions at around 38 and 2.4 mg/dl, respectively. Fluid balance decreased progressively and stabilized around zero after five sessions. Weekly delivered Kt/V was 5.94±0.7. Hypotension and filter clotting occurred in 47.5 and 12.4% of treatment session, respectively. Regarding AKI outcome, 22.5% of patients presented renal function recovery, 5.6% of patients remained on dialysis after 30 days, and 71.9% of patients died. Age and focus abdominal sepsis were identified as risk factors for death. Urine output and negative fluid balance were identified as protective factors.EDD is effective for AKI patients, allowing adequate metabolic and fluid control. Age, focus abdominal sepsis, and lower urine output as well as positive fluid balance after two EDD sessions were associated significantly with death.

  17. Status Of The National Ignition Campaign And National Ignition Facility Integrated Computer Control System

    Energy Technology Data Exchange (ETDEWEB)

    Lagin, L; Brunton, G; Carey, R; Demaret, R; Fisher, J; Fishler, B; Ludwigsen, P; Marshall, C; Reed, R; Shelton, R; Townsend, S

    2011-03-18

    The National Ignition Facility (NIF) at the Lawrence Livermore National Laboratory is a stadium-sized facility that will contains a 192-beam, 1.8-Megajoule, 500-Terawatt, ultraviolet laser system together with a 10-meter diameter target chamber with room for multiple experimental diagnostics. NIF is the world's largest and most energetic laser experimental system, providing a scientific center to study inertial confinement fusion (ICF) and matter at extreme energy densities and pressures. NIF's laser beams are designed to compress fusion targets to conditions required for thermonuclear burn. NIF is operated by the Integrated Computer Control System (ICCS) in an object-oriented, CORBA-based system distributed among over 1800 frontend processors, embedded controllers and supervisory servers. In the fall of 2010, a set of experiments began with deuterium and tritium filled targets as part of the National Ignition Campaign (NIC). At present, all 192 laser beams routinely fire to target chamber center to conduct fusion and high energy density experiments. During the past year, the control system was expanded to include automation of cryogenic target system and over 20 diagnostic systems to support fusion experiments were deployed and utilized in experiments in the past year. This talk discusses the current status of the NIC and the plan for controls and information systems to support these experiments on the path to ignition.

  18. Pheromone use for insect control: present status and prospect in Bangladesh

    Directory of Open Access Journals (Sweden)

    Md. Azharul Islam

    2012-06-01

    Full Text Available The insect’s world is filled with many odors. Insects use these odors to cue them in a variety of complex social behaviors, including courtship, mating, and egg laying. Scientists and pest control specialists have known about these complex communication systems for decades. The main aim of this study was to visualize the availability, trends and differences in the sources of pheromone control in agricultural growth of Bangladesh. It also concerned on constrains and present use of pheromone and their possible recommendation on behalf of Bangladesh agriculture. It concentrated on the data during last three decades (1980-2010, comprising status of pheromone use in Bangladesh agriculture and its future. Review revealed that Bangladesh has been enormously successful in increasing pheromone use in agricultural production (especially for vegetables. Understanding of the nature of pheromones and their potential for pest control along with the future prospective of pheromone technique in agriculture were stated. Since the pheromone, technologies for control of major crop pests in Bangladesh are still limited. So that this review emphasized on more attention to the authority to increase the research works and project facilities related to develop and promote pheromone techniques. It is highly recommended to increase availability of pheromone in market, more investment in research and development, introduction of newly identified pheromone for specific pest, to assist government and non-government organizations to work with farmers to reduce harmful insecticide use and promote pheromone tactics as one part of integrated crop management (ICM.

  19. Glycemic control in diabetic children: role of mother's knowledge and socioeconomic status.

    Science.gov (United States)

    Tahirovic, Husref; Toromanovic, Alma

    2010-08-01

    The aim of this study is to investigate the role of mother's knowledge and socioeconomic status (SES) of the family on glycemic control in diabetic children. Our sample was taken from successive admissions to the outpatient's diabetes clinics in Tuzla, Bosnia and Herzegovina. Diabetes knowledge was assessed using the Michigan Diabetes Research and Training Center Diabetes Knowledge Test. Glycemic control was assessed by glycosylated hemoglobin (HbA(1C)). The mother's demographics were obtained by self-report. To categorize families' SES, parents' level of education, and current employment were recorded and analyzed using the Hollingshed two-factor index of social position. As expected, higher mother's knowledge was significantly associated with lower HbA(1C) (r = -0.2861705, p = 0.0442). Also, a significant correlation was found between the families' SES and HbA(1C) levels (r = 0.4401921; p = 0.0015). Mothers with more knowledge have children with better metabolic control, and low SES is significantly associated with higher levels of HbA1c. Improvement of mothers' knowledge and family SES may improve glycemic control and ultimately decrease acute and chronic complications of diabetes in children.

  20. Comparing the Effect of Intravenous Midazolam with Rectal Sodium Valproate in Controlling of Children with Refractory Status Epilepticus

    Directory of Open Access Journals (Sweden)

    T Mahmoudian

    2006-01-01

    Full Text Available Background: Refractory status epilepticus usually defined as a seizure lasting at least 60 minutes which is uncontrollable by Diazepam, Phenytoin, or Phenobarbital. The aim of this study was to compare the effect of interavenous Midazolam and rectal Sodium valproate in controlling refractory status epilepticus. Methods: In this case-control study; 76 children with (mean age of 37± 20 months with refractory status epilepticus were randomly divided into two groups to receive IV Midazolam and rectal Sodium Valproate. The effect of the two drugs were compared in control of seizure during first 20 minutes of treatment. Results: In 84.2 percent of children treated with IV Midazolam, the seizure was under control within 4.5 ± 0.5 minutes, while in 63 percent of those receiving Sodium Valproate, the seizure was completely controlled within 16.5 ± 0.8 minutes (P < 0.00001. Conclusion: The IV Midazolam was more effective than Sodium valproate, but the latter can be used in hospitals or pediatric emergency wards without ICU for controlling of refractory status epilepticus. Key words: refractory status epilepticus, midazolam, sodium valproate

  1. Biofluid mechanics of special organs and the issue of system control. Sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008 Pasadena, California.

    Science.gov (United States)

    Zamir, Mair; Moore, James E; Fujioka, Hideki; Gaver, Donald P

    2010-03-01

    In the field of fluid flow within the human body, focus has been placed on the transportation of blood in the systemic circulation since the discovery of that system; but, other fluids and fluid flow phenomena pervade the body. Some of the most fascinating fluid flow phenomena within the human body involve fluids other than blood and a service other than transport--the lymphatic and pulmonary systems are two striking examples. While transport is still involved in both cases, this is not the only service which they provide and blood is not the only fluid involved. In both systems, filtration, extraction, enrichment, and in general some "treatment" of the fluid itself is the primary function. The study of the systemic circulation has also been conventionally limited to treating the system as if it were an open-loop system governed by the laws of fluid mechanics alone, independent of physiological controls and regulations. This implies that system failures can be explained fully in terms of the laws of fluid mechanics, which of course is not the case. In this paper we examine the clinical implications of these issues and of the special biofluid mechanics issues involved in the lymphatic and pulmonary systems.

  2. Thermal Fluid-Dynamic Study for the thermal control of the new ALICE Central Detectors

    CERN Document Server

    Pelizzari, Andrea

    The Inner Tracking System Detector of the ALICE Experiment at CERN laboratory will be replaced in 2020 with a new Detector. It will have to provide, among others, higher spatial resolution, higher tracking precision and faster data read-out. These goals will be attained thanks to new pixel sensors chips and new electronic components, which will have a high impact in terms of dissipated heat. Therefore, one of the critical aspects for the success of the Upgrade project is the design of the Detector cooling system. This thesis work has been developed at CERN in Geneva in close contact with the group responsible for the Mechanics and Cooling of the Detector. The aim of the thermal fluid dynamic study devised is to deliver to the group a reliable and accurate description of the air flow inside the New Inner Tracking System Detector. After a first part of problem definition and design study, a Computational Fluid Dynamic (CFD) analysis has been developed with the ANSYS Fluent software. The CFD model built in this ...

  3. Fracturing controlled primary migration of hydrocarbon fluids during heating of organic-rich shales

    CERN Document Server

    Kobchenko, Maya; Renard, Francois; Dysthe, Dag Kristian; Malthe-Sorenssen, Anders; Mazzini, Adriano; Scheibert, Julien; Jamtveit, Bjorn; Meakin, Paul

    2011-01-01

    Time-resolved three-dimensional in situ high resolution synchrotron x-ray tomographic imaging was used to investigate the effects of slowly heating organic-rich Green River Shale from 60\\deg; to 400\\deg;C, in air without confinement, to better understand primary migration of hydrocarbon fluids in very low permeability source rock. Cracks nucleate in the interior of the sample at a temperature around 350\\deg;C. As the temperature increases, they grow and coalesce along lamination planes to form bigger cracks. This process is accompanied by a release of light hydrocarbons generated by decomposition of the initially immature organic matter, as determined by thermogravimetry and gas chromatography. These results provide the first 4D monitoring of an invasion percolation-like fracturing process in organic-rich shales. This process increases the permeability of the sample and provides pathways for fluid expulsion - an effect that might also be relevant for primary migration under natural conditions. We propose a 2D...

  4. Characterization and Testing of an Electrorheological Fluid Valve for Control of ERF Actuators

    Directory of Open Access Journals (Sweden)

    Quang-Anh Nguyen

    2015-06-01

    Full Text Available Previous studies of electrorheological fluids (ERFs were motivated by brake, clutch, damping, haptic and resistive applications, but never motivated towards developing an ERF based-hydraulic rotary actuator. One design to make such an actuator is to use ERF-based valves. To fully understand the performance of such an actuator, it is imperative to study ERF valves. For this reason, this paper presents a summary of design considerations for creating ERF-based actuators, an ERF-based valve design for an ERF actuator and a new experimental test-bed to obtain viscosity and yield characteristics of the ERF at flow rates as low as 0.049 L/min, an order of magnitude lower than industrial rheometers. The new test-bed successfully measured the dynamic viscosity of the ERF to be at 0.6 Pa-s for low flow rates and 0.2 Pa-s for higher flow rates. The presented valve design can successfully resist 1 MPa of fluid pressure, which is an operation mode higher than any haptic and damping applications in the literature. The experiments also shows that higher flow rates negatively affect the ERF’s yield characteristics for the first time in a situation where the ERF valve completely blocks flow. When the flow rates are increased, the response time to a fully-closed valve increases, the effective yield capability of the ERF decreases and the conductivity of the ERF increases.

  5. Experimental study on controls on fluid chemistry and permeability evolution during serpentinization reactions

    Science.gov (United States)

    Farough, A.; Moore, D. E.; Lockner, D. A.; Lowell, R. P.

    2013-12-01

    Serpentinization plays a key role in hydrothermal processes and structural deformation at slow and ultraslow mid-ocean ridges, where it is commonly associated with the formation of oceanic core complexes and detachment faults. Many details of how serpentinization reactions progress at small scales and the links between the reactions and changes in permeability and stresses are poorly understood. To advance our understanding of the evolution of permeability and fluid chemistry accompanying serpentinization reactions and provide a framework for developing more realistic models at a larger scale, we performed a series of high-temperature permeability experiments on fractured solid ultramafic rock samples that reasonably simulate serpentinization in natural settings. Experimental conditions were 260°C, 50 MPa confining pressure, and 20×2 MPa pore pressure. Ultramafic rock types containing different proportions of olivine and pyroxene were tested, to investigate the effect of mineral assemblage on fluid-rock interaction and permeability. Samples were cylindrical cores of 18 mm diameter and 23 mm length that were split axially to form a well-mated tensile fracture, jacketed in a 0.5 mm thick teflon liner and inserted into a 0.4 mm thick annealed silver jacket. A 7.5 mm thick layer of the same rock, crushed and sieved (0.18-1.0 mm size range) was placed on the inlet side of the sample to produce a coarse-grained gouge. The gouge layer provided a heated fluid reservoir with which the deionized water, used as pore fluid, could equilibrate before entering the fracture. Routinely, about 1 cm3 of water was pumped through the sample each day and collected (without dropping sample pore pressure) for chemical analysis. Pore fluid flow was in one direction and the pore pressure change and flow rate were recorded to determine permeability. In most samples, the initial fracture permeability at 260°C was between 10-15 and 10-18 m2, and decreased by about 3 orders of magnitude in

  6. Controlling the HIV/AIDS epidemic: current status and global challenges

    Directory of Open Access Journals (Sweden)

    Thorsten eDemberg

    2012-08-01

    Full Text Available This review provides an overview of the current status of the global HIV pandemic and strategies to bring it under control. It updates numerous preventive approaches including behavioral interventions, male circumcision, pre- and post-exposure prophylaxis, vaccines, and microbicides. The manuscript summarizes current anti-retroviral treatment options, their impact in the western world, and difficulties faced by emerging and resource-limited nations in providing and maintaining appropriate treatment regimens. Current clinical and pre-clinical approaches towards a cure for HIV are described, including new drug compounds that target viral reservoirs and gene therapy approaches aimed at altering susceptibility to HIV infection. Recent progress in vaccine development is summarized, including novel approaches and new discoveries.

  7. Mortality studies of metalworking fluid exposure in the automobile industry: VI. A case-control study of esophageal cancer.

    Science.gov (United States)

    Sullivan, P A; Eisen, E A; Woskie, S R; Kriebel, D; Wegman, D H; Hallock, M F; Hammond, S K; Tolbert, P E; Smith, T J; Monson, R R

    1998-07-01

    Results are reported from a nested case-control study of 60 esophageal cancer deaths among 46,384 automobile manufacturing workers potentially exposed to metalworking fluids (MWF) in machining and grinding operations. By using incidence-density sampling, controls were selected with a sampling ratio of 20:1 from among co-workers who remained at risk by the age of death of the case, matched on race, gender, plant, and year of birth. Conditional logistic regression was used to evaluate the risk associated with cumulative exposure (mg/m3-years) to each of three types of metalworking fluid (straight, soluble, and synthetic MWF), as well as with years of exposure to selected components of MWF, including nitrosamines, sulfur, biocides, and several metals. Esophageal cancer was found to be significantly associated with exposure to both soluble and synthetic MWF in grinding operations. The odds ratios (ORs) for grinding with soluble MWF were elevated at 2.5 or greater in all categories of cumulative exposure, although the exposure-response trend was statistically significant only when exposure was measured as duration. Those with 12 or more years exposure to soluble MWF in grinding operations experienced a 9.3-fold relative risk of esophageal cancer mortality (95% CI = 2.1-42.1). The OR for ever grinding with synthetic MWF was 4.1 (95% CI = 1.1-15.0). Elevated risk was also associated with two agents found in both synthetic and soluble fluids, nitrosamines, and biocides. For exposure to nitrosamines, the OR was 5.4 (95% CI = 1.5-19.9); for biocides the OR was 3.8 (95% CI = 0.8-18.9). However, because the same workers were exposed to grinding with synthetics, nitrosamines and biocides, it was not possible to separate the specific risks associated with these components.

  8. Muslim consumer trust in halal meat status and control in Belgium.

    Science.gov (United States)

    Bonne, Karijn; Verbeke, Wim

    2008-05-01

    This paper focuses on public trust of Belgian Muslims in information sources of halal meat and their confidence in key actors and institutions for monitoring and controlling the halal meat chain. Cross-sectional consumer data were collected through a survey with 367 Muslims during the summer of 2006 in Belgium. Findings reveal that Islamic institutions and especially the Islamic butcher receive in general most confidence for monitoring and controlling the halal status of meat, and for communicating about halal meat. However, based on Muslims' confidence, four distinct market segments were identified: indifferent (29.1%), concerned (9.7%), confident (33.1%) and Islamic idealist (26.7%). These segments differ significantly with respect to trust in information sources and institutions, health and safety perception of halal meat, perceived halal meat consumption barriers, behavioural variables (halal meat consumption frequency and place of purchase), and socio-cultural (acculturation and self-identity) and individual characteristics. Indifferent consumers are rather undecided about who should monitor the halal status of meat, and they are most open to purchasing halal meat in the supermarket. Concerned Muslim consumers display higher confidence in Belgian than in Islamic institutions, which associates with perceiving a lack of information, poor hygiene and safety concern as barriers to purchasing halal meat. Confident consumers display a clear preference for Islamic institutions to monitor and communicate about halal. Islamic idealists, who are typified by younger age, second generation and high Muslim self-identity, differ from the confident consumers through their very low confidence in local Belgian sources and institutions.

  9. Status and Control Requirements of the Planned Heavy Ion Tumor Therapy Accelerator Facility HICAT

    CERN Document Server

    Baer, R C; Haberer, T; Baer, Ralph C.; Eickhoff, Hartmut; Haberer, Thomas

    2001-01-01

    The HICAT project is a Heavy Ion accelerator for light ion Cancer Treatment to be built for the clinics in Heidelberg, Germany. It consists of a 7 MeV/u linac, a compact synchrotron and three treatment places, one of them equipped with a 360 degree gantry beam-line. The facility will implement the intensity controlled raster-scanning technique that was developed and successfully demonstrated at GSI with over 100 patients at present. In order to produce the beams with the characteristics requested by the treatment sequencer, the accelerator must operate on a pulse-to-pulse basis with different settings. This concept imposes strict and challenging demands on the operation of the accelerators and hence the control system of the facility. The control system should be developed, installed and maintained by and under the complete responsibility of an industrial system provider, using a state-of-the-art system and wide-spread industrial components wherever possible. The presentation covers the status of the project ...

  10. Cysticercosis/taeniasis endemicity in Southeast Asia: Current status and control measures.

    Science.gov (United States)

    Wu, Hai-Wei; Ito, Akira; Ai, Lin; Zhou, Xiao-Nong; Acosta, Luz P; Lee Willingham Iii, Arve

    2017-01-01

    The parasitic zoonoses cysticercosis/taeniasis is among the 17 major Neglected Tropical Diseases (NTDs) identified by the WHO as a focus for research and control. It is caused by a larval stage (cysticercus) infection of Taenia solium tapeworm in both humans and pigs. Cysticercosis occurs in many resource-poor countries, especially those with warm and mild climates in the regions of Latin America (LA), Asia and Sub-Saharan Africa (SSA). The prevalence of human cysticercosis is marked in those areas where individuals are traditionally keen to consume raw or insufficiently cooked pork and/or where the husbandry of pigs is improper. The worldwide burden of cysticercosis is unclear and notably, large-scale control initiatives are lacking in all regions. This review focuses on the current endemic status of cysticercosis caused by T. solium infection in both humans and pigs living in 13 Southeast Asian countries. We will also emphasize epidemiological data as well as prevention and control of human neurocysticercosis.

  11. Natural Killer Cell Assessment in Peripheral Circulation and Bronchoalveolar Lavage Fluid of Patients with Severe Sepsis: A Case Control Study

    Science.gov (United States)

    Souza-Fonseca-Guimaraes, Paulo; Guimaraes, Fernando; Natânia De Souza-Araujo, Caroline; Maria Boldrini Leite, Lidiane; Cristina Senegaglia, Alexandra; Nishiyama, Anita; Souza-Fonseca-Guimaraes, Fernando

    2017-01-01

    Sepsis is a complex systemic inflammatory syndrome, the most common cause of which is attributed to systemic underlying bacterial infection. The complete mechanisms of the dynamic pro- and anti-inflammatory processes underlying the pathophysiology of sepsis remain poorly understood. Natural killer (NK) cells play a crucial role in the pathophysiology of sepsis, leading to exaggerated inflammation due their rapid response and production of pro-inflammatory cytokines such as interferon gamma (IFN-γ). Several studies have already shown that NK cells undergo lymphopenia in the peripheral blood of patients with sepsis. However, our understanding of the mechanisms behind its cellular trafficking and its role in disease development is restricted to studies in animal models. In this study, we aimed to compare the human NK cell subset (CD56bright or dim) levels in the peripheral blood and bronchoalveolar lavage (BAL) fluid of sepsis patients. We conducted a case-control study with a sample size consisting of 10 control patients and 23 sepsis patients enrolled at the Hospital Cajuru (Curitiba/PR, Brazil) from 2013 to 2015. Although we were able to confirm previous observations of peripheral blood lymphopenia, no significant differences were detected in NK cell levels in the BAL fluid of these patients. Overall, these findings strengthened the evidence that peripheral blood lymphopenia is likely to be associated with cell death as a consequence of sepsis. PMID:28287491

  12. Natural Killer Cell Assessment in Peripheral Circulation and Bronchoalveolar Lavage Fluid of Patients with Severe Sepsis: A Case Control Study.

    Science.gov (United States)

    Souza-Fonseca-Guimaraes, Paulo; Guimaraes, Fernando; Natânia De Souza-Araujo, Caroline; Maria Boldrini Leite, Lidiane; Cristina Senegaglia, Alexandra; Nishiyama, Anita; Souza-Fonseca-Guimaraes, Fernando

    2017-03-12

    Sepsis is a complex systemic inflammatory syndrome, the most common cause of which is attributed to systemic underlying bacterial infection. The complete mechanisms of the dynamic pro- and anti-inflammatory processes underlying the pathophysiology of sepsis remain poorly understood. Natural killer (NK) cells play a crucial role in the pathophysiology of sepsis, leading to exaggerated inflammation due their rapid response and production of pro-inflammatory cytokines such as interferon gamma (IFN-γ). Several studies have already shown that NK cells undergo lymphopenia in the peripheral blood of patients with sepsis. However, our understanding of the mechanisms behind its cellular trafficking and its role in disease development is restricted to studies in animal models. In this study, we aimed to compare the human NK cell subset (CD56(bright or dim)) levels in the peripheral blood and bronchoalveolar lavage (BAL) fluid of sepsis patients. We conducted a case-control study with a sample size consisting of 10 control patients and 23 sepsis patients enrolled at the Hospital Cajuru (Curitiba/PR, Brazil) from 2013 to 2015. Although we were able to confirm previous observations of peripheral blood lymphopenia, no significant differences were detected in NK cell levels in the BAL fluid of these patients. Overall, these findings strengthened the evidence that peripheral blood lymphopenia is likely to be associated with cell death as a consequence of sepsis.

  13. Functional status in children with ADHD at age 6-8: a controlled community study.

    Science.gov (United States)

    Efron, Daryl; Sciberras, Emma; Anderson, Vicki; Hazell, Philip; Ukoumunne, Obioha C; Jongeling, Brad; Schilpzand, Elizabeth J; Bisset, Matthew; Nicholson, Jan M

    2014-10-01

    To examine the functional status (mental health, academic performance, peer problems) of a community-based sample of children who have attention-deficit/hyperactivity disorder (ADHD) and non-ADHD controls, and to investigate gender and subtype differences. Children aged 6 to 8 years were recruited through 43 Melbourne schools, using a 2-stage screening (parent and teacher Conners 3 ADHD index) and case confirmation (Diagnostic Interview Schedule for Children, Version IV; [DISC-IV]) procedure. Outcome measures were mental health disorders (DISC-IV), academic performance (Wide Range Achievement Test 4), and peer problems (Strength and Difficulties Questionnaire). Unadjusted and adjusted linear and logistic regression were used to compare ADHD and non-ADHD controls. A total of 179 children who have ADHD and 212 non-ADHD controls were recruited. Compared with controls, children who had ADHD had higher odds of externalizing (odds ratio [OR], 11.0; 95% confidence interval [CI], 5.6-21.6; P < .001) and internalizing (OR, 2.9; 95% CI, 1.2-7.2; P = .02) disorders; poorer reading (effect size, -0.66) and mathematics (effect size, -0.69) performance; and more peer problems (P < .001). Boys and girls who had ADHD were equally impaired. Only 17% of children in our ADHD group had been previously diagnosed. Previous diagnosis was higher in the Combined group and for boys. In their second year of school, children who had ADHD performed worse than controls across all functional domains, yet only a minority had been formally diagnosed with ADHD. Findings highlight the need for earlier diagnosis and intervention. Copyright © 2014 by the American Academy of Pediatrics.

  14. Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain

    Science.gov (United States)

    Murlidharan, Giridhar; Crowther, Andrew; Reardon, Rebecca A.; Song, Juan

    2016-01-01

    Adeno-associated viruses (AAV) are currently being evaluated in clinical trials for gene therapy of CNS disorders. However, host factors that influence the spread, clearance, and transduction efficiency of AAV vectors in the brain are not well understood. Recent studies have demonstrated that fluid flow mediated by aquaporin-4 (AQP4) channels located on astroglial end feet is essential for exchange of solutes between interstitial and cerebrospinal fluid. This phenomenon, which is essential for interstitial clearance of solutes from the CNS, has been termed glial-associated lymphatic transport or glymphatic transport. In the current study, we demonstrate that glymphatic transport profoundly affects various aspects of AAV gene transfer in the CNS. Altered localization of AQP4 in aged mouse brains correlated with significantly increased retention of AAV vectors in the parenchyma and reduced systemic leakage following ventricular administration. We observed a similar increase in AAV retention and transgene expression upon i.c.v. administration in AQP4–/– mice. Consistent with this observation, fluorophore-labeled AAV vectors showed markedly reduced flux from the ventricles of AQP4–/– mice compared with WT mice. These results were further corroborated by reduced AAV clearance from the AQP4-null brain, as demonstrated by reduced transgene expression and vector genome accumulation in systemic organs. We postulate that deregulation of glymphatic transport in aged and diseased brains could markedly affect the parenchymal spread, clearance, and gene transfer efficiency of AAV vectors. Assessment of biomarkers that report the kinetics of CSF flux in prospective gene therapy patients might inform variable treatment outcomes and guide future clinical trial design. PMID:27699236

  15. Dental caries status of patients with schizophrenia in Seville, Spain: a case-control study.

    Science.gov (United States)

    Velasco-Ortega, Eugenio; Monsalve-Guil, L; Ortiz-Garcia, I; Jimenez-Guerra, A; Lopez-Lopez, J; Segura-Egea, J J

    2017-01-18

    The aim of this study was to assess the dental status (DMFT) in patients with schizophrenia compared with a control group. In this case-control study, 50 patients with schizophrenia attended in the Psychiatric Unit at the Virgen Macarena University Hospital of Seville were compared with 50 people (without systemic diseases and not taking psychotropic drugs) in a control group attended in the School of Dentistry of Seville. Decayed, missing and filled teeth (DMFT) were assessed according to the World Health Organization WHO criteria. Patients with schizophrenia showed a decayed teeth (DT) score of 7.26 ± 5.69 compared with 6.50 ± 4.37 for patients the control group. These differences were significant and suggest that dental caries are most prevalent in patients with schizophrenia. People who smoked showed significantly higher DT scores in both groups. Among patients with schizophrenia, smokers scored 9.34 ± 5.42 compared with 4.38 ± 4.82 for non-smokers. Among the healthy controls, smokers scored 6.88 ± 4.85 compared with 6.12 ± 3.85 for non-smokers (p schizophrenia showed a missing teeth (MT) score of 9.10 ± 8.56 compared with 5.38 ± 5.14 in control patients. MT scores increased significantly with age and with smoking in both groups of patients (p schizophrenia showed a filled teeth (FT) score of 1.38 ± 2.70 compared with 2.34 ± 3.48 in control patients. FT differences in gender and smoking habits between patients with schizophrenia and healthy control subjects were statistically significant (p schizophrenia have extensive untreated dental disease. Patients with schizophrenia constitute a high risk population for dental health. This group showed a greater prevalence of decayed and missing teeth and more extensive treatment needs.

  16. Knowledge, Attitude, Practice, and Status of Infection Control among Iranian Dentists and Dental Students: A Systematic Review

    OpenAIRE

    Moradi Khanghahi, Behnam; Jamali, Zahra; Pournaghi Azar, Fatemeh; Naghavi Behzad, Mohammad; Azami-Aghdash, Saber

    2013-01-01

    Background and aims Infection control is an important issue in dentistry, and the dentists are primarily responsible for observing the relevant procedures. Therefore, the present study evaluated knowledge, attitude, practice, and status of infection control among Iranian dentists through systematic review of published results. Materials and methods In this systematic review, the required data was collected searching for keywords including infection, infection control, behavior, performance, p...

  17. Implementation of the Framework Convention on Tobacco Control in Africa: Current Status of Legislation

    Directory of Open Access Journals (Sweden)

    Jacqueline Tumwine

    2011-11-01

    Full Text Available Objective: To describe, as of July 2011, the status of tobacco control legislation in Africa in three key areas of the Framework Convention on Tobacco Control (FCTC—(1 Protection from exposure to tobacco smoke, (2 Packaging and labelling of tobacco products, and (3 Tobacco advertising, promotion and sponsorship. Methods: Review and analysis of tobacco control legislation in Africa, media reports, journal articles, tobacco industry documents and data published in the 2011 WHO Report on the Global Tobacco Epidemic. Results: Modest progress in FCTC implementation in Africa with many countries having legislation or policies on the protection from exposure to tobacco smoke, however, only a handful of countries meet the standards of the FCTC Article 8 and its Guidelines particularly with regards to designated smoking areas. Little progress on packaging and labelling of tobacco products, with few countries having legislation meeting the minimum standards of the FCTC Article 11 and its Guidelines. Mauritius is the only African country with graphic or pictorial health warnings in place and has the largest warning labels in Africa. Slightly better progress in banning tobacco advertising, promotion and sponsorship has been shown by African countries, although the majority of legislation falls short of the standards of the FCTC Article 13 and its Guidelines. Despite their efforts, African countries’ FCTC implementation at national level has not matched the strong regional commitment demonstrated during the FCTC treaty negotiations. Conclusion: This study highlights the need for Africa to step up efforts to adopt and implement effective tobacco control legislation that is fully compliant with the FCTC. In order to achieve this, countries should prioritise resources for capacity building for drafting strong FCTC compliant legislation, research to inform policy and boost political will, and countering the tobacco industry which is a major obstacle to FCTC

  18. Current status and Future Works in Dynamic Control Rod Worth Measurement Method in KOREA

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eun-ki; Shin, Ho-chul [Korea Hydro Nuclear Power Co. Central Research Inst, Daejeon (Korea, Republic of)

    2015-10-15

    Actually all ex-core detector signal data processing and extracting the final conclusion about the single control bank was performed by the 3rd generation of Digital Reactivity Computer System (DRCS). From 2006 to 2016, about 250 control bank worths were measured and the difference between measured and calculated worth of individual bank were several % and total rod worth differences of each cycle were less than 3%. However there were a few odd cases showing the individual difference greater than 15% which is the criteria. And some OPR1000 nuclear power plants built recently use fission chambers instead of traditional uncompensated ion chambers. To consider those conditions, any modification of the DCRM method and DRCS were requested. In this paper, short description about DCRM method, current status of DCRM modification and future works are discussed. About 10 cases among about 250 control bank worth measurement with original DCRM method with UIC signals result in very heavy fluctuation on reactivity curve and the difference approaches 15%, the individual limit. The electrometer signals processing method were the main cause. To overcome this problem, a modified reactivity computer system using own current treatment logic was designed. It shows the reactivity fluctuation can be reduced dramatically in case of UIC signal. Recently the modified DRCS coupled INVESE code applied Westinghouse 2 Loop plant and gave very good results except a control bank whose measured rod worth was shown of 18% difference from the estimated value. The results were same for three repeat tests. All possible causes are examined from computer codes to detail data acquisition system.

  19. Status of the National Ignition Facility Integrated Computer Control System (ICCS) on the path to ignition

    Energy Technology Data Exchange (ETDEWEB)

    Lagin, L.J. [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550 (United States)], E-mail: lagin1@llnl.gov; Bettenhausen, R.C.; Bowers, G.A.; Carey, R.W.; Edwards, O.D.; Estes, C.M.; Demaret, R.D.; Ferguson, S.W.; Fisher, J.M.; Ho, J.C.; Ludwigsen, A.P.; Mathisen, D.G.; Marshall, C.D.; Matone, J.T.; McGuigan, D.L.; Sanchez, R.J.; Stout, E.A.; Tekle, E.A.; Townsend, S.L.; Van Arsdall, P.J. [Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94550 (United States)] (and others)

    2008-04-15

    final optics, target positioners and diagnostics. Additional capabilities to support fusion ignition shots in a National Ignition Campaign (NIC) beginning in 2010 will include a cryogenic target system, target diagnostics, and integrated experimental shot data analysis with tools for data visualization and archiving. This talk discusses the current status of the control system implementation and discusses the plan to complete the control system on the path to ignition.

  20. Current Status of Air Toxics Management and Its Strategies for Controlling Emissions in Taiwan

    Directory of Open Access Journals (Sweden)

    Wen-Tien Tsai

    2016-04-01

    Full Text Available Since the 1970s, hazardous air pollutants (HAPs, so-called air toxics, have been of great concern because they can cause serious human health effects and have adverse effects on the environment. More noticeably, some of them are known to be human carcinogens. The objective of this paper is to investigate the regulatory systems and human health effects of air toxics which have been designated by the Taiwan government under the Air Pollution Control Act. These toxic air pollutants include acutely toxic gas (i.e., ammonia, chlorine, fluorides, hydrochloric acid, hydrogen cyanide, hydrogen sulfide, nitric acid, phosphoric acid and sulfuric acid, gas containing heavy metals, and carcinogenic chemicals (including formaldehyde, vinyl chloride, asbestos and matter containing asbestos, dioxins and furans, volatile organic compounds, polycyclic aromatic hydrocarbons, and polychlorinated biphenyls. In line with international concern about the carcinogenic risk and environmental persistence of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDDs/PCDFs and heavy metals in recent years, the current status in monitoring and reducing the emissions of PCDDs/PCDFs from stationary sources was analyzed as a case study in the present study. Furthermore, the control strategies for reducing emissions of air toxics from stationary sources in Taiwan were also addressed.

  1. Interrelationships between lipid peroxidation and total antioxidant status in sedentary controls and unprofessional athletes.

    Science.gov (United States)

    Caimi, Gregorio; Canino, Baldassare; Lo Presti, Rosalia

    2010-01-01

    We examined the thiobarbituric acid-reactive substances (TBARS) as an index of lipid peroxidation, and the total antioxidant status (TAS) in 81 unprofessional athletes subdivided into three subgroups. The first group included 28 subjects who practised endurance sports, the second included 30 subjects who practised mixed sports, the third included 23 subjects who practised power sports. We enrolled also a group of 61 sedentary controls (SC). TBARS were increased and TAS was decreased in the whole group of athletes in comparison with SC; an almost similar behaviour was present also subdividing athletes according to the practised sport. A significant negative correlation between these two parameters emerged in SC but not in the whole group of athletes. Unless for the athletes that practised endurance sports a similar trend was found in athletes that practised mixed and power sports. In conclusion, at rest the symmetrical behaviour between the lipid peroxidation increase and the TAS decrease, observed in sedentary controls, was not evident in unprofessional athletes who practised different sports.

  2. Controlling Time-Dependent Confounding by Health Status and Frailty: Restriction Versus Statistical Adjustment.

    Science.gov (United States)

    McGrath, Leah J; Ellis, Alan R; Brookhart, M Alan

    2015-07-01

    Nonexperimental studies of preventive interventions are often biased because of the healthy-user effect and, in frail populations, because of confounding by functional status. Bias is evident when estimating influenza vaccine effectiveness, even after adjustment for claims-based indicators of illness. We explored bias reduction methods while estimating vaccine effectiveness in a cohort of adult hemodialysis patients. Using the United States Renal Data System and linked data from a commercial dialysis provider, we estimated vaccine effectiveness using a Cox proportional hazards marginal structural model of all-cause mortality before and during 3 influenza seasons in 2005/2006 through 2007/2008. To improve confounding control, we added frailty indicators to the model, measured time-varying confounders at different time intervals, and restricted the sample in multiple ways. Crude and baseline-adjusted marginal structural models remained strongly biased. Restricting to a healthier population removed some unmeasured confounding; however, this reduced the sample size, resulting in wide confidence intervals. We estimated an influenza vaccine effectiveness of 9% (hazard ratio = 0.91, 95% confidence interval: 0.72, 1.15) when bias was minimized through cohort restriction. In this study, the healthy-user bias could not be controlled through statistical adjustment; however, sample restriction reduced much of the bias.

  3. The Use of Limited Fluid Resuscitation and Blood Pressure-Controlling Drugs in the Treatment of Acute Upper Gastrointestinal Hemorrhage Concomitant with Hemorrhagic Shock.

    Science.gov (United States)

    Lu, Bo; Li, Mao-Qin; Li, Jia-Qiong

    2015-06-01

    The aim of this study was to evaluate the usefulness of the limited fluid resuscitation regimen combined with blood pressure-controlling drugs in treating acute upper gastrointestinal hemorrhage concomitant with hemorrhagic shock. A total of 51 patients were enrolled and divided into a group that received traditional fluid resuscitation group (conventional group, 24 patients) and a limited fluid resuscitation group (study group, 27 patients). Before and after resuscitation, the blood lactate, base excess, and hemoglobin values, as well as the volume of fluid resuscitation and resuscitation time were examined. Compared with conventional group, study group had significantly better values of blood lactate, base excess, and hemoglobin (all p bleeding control and resuscitation effectiveness.

  4. A statistical learning strategy for closed-loop control of fluid flows

    Science.gov (United States)

    Guéniat, Florimond; Mathelin, Lionel; Hussaini, M. Yousuff

    2016-12-01

    This work discusses a closed-loop control strategy for complex systems utilizing scarce and streaming data. A discrete embedding space is first built using hash functions applied to the sensor measurements from which a Markov process model is derived, approximating the complex system's dynamics. A control strategy is then learned using reinforcement learning once rewards relevant with respect to the control objective are identified. This method is designed for experimental configurations, requiring no computations nor prior knowledge of the system, and enjoys intrinsic robustness. It is illustrated on two systems: the control of the transitions of a Lorenz'63 dynamical system, and the control of the drag of a cylinder flow. The method is shown to perform well.

  5. A statistical learning strategy for closed-loop control of fluid flows

    CERN Document Server

    Guéniat, Florimond; Hussaini, M Yousuff

    2016-01-01

    This work discusses a closed-loop control strategy for complex systems utilizing scarce and streaming data. A discrete embedding space is first built using hash functions applied to the sensor measurements from which a Markov process model is derived, approximating the complex system's dynamics. A control strategy is then learned using reinforcement learning once rewards relevant with respect to the control objective are identified. This method is designed for experimental configurations, requiring no computations nor prior knowledge of the system, and enjoys intrinsic robustness. It is illustrated on two systems: the control of the transitions of a Lorenz 63 dynamical system, and the control of the drag of a cylinder flow. The method is shown to perform well.

  6. Application of the Poor Man's Navier-Stokes Equations to Real-Time Control of Fluid Flow

    Directory of Open Access Journals (Sweden)

    James B. Polly

    2012-01-01

    Full Text Available Control of fluid flow is an important, underutilized process possessing potential benefits ranging from avoidance of separation and stall on aircraft wings to reduction of friction in oil and gas pipelines to mitigation of noise from wind turbines. But the Navier-Stokes (N.-S. equations, whose solutions describe such flows, consist of a system of time-dependent, multidimensional, nonlinear partial differential equations (PDEs which cannot be solved in real time using current computing hardware. The poor man's Navier-Stokes (PMNS equations comprise a discrete dynamical system that is algebraic—hence, easily (and rapidly solved—and yet which retains many (possibly all of the temporal behaviors of the PDE N.-S. system at specific spatial locations. Herein, we outline derivation of these equations and discuss their basic properties. We consider application of these equations to the control problem by adding a control force. We examine the range of behaviors that can be achieved by changing this control force and, in particular, consider controllability of this (nonlinear system via numerical experiments. Moreover, we observe that the derivation leading to the PMNS equations is very general and may be applied to a wide variety of problems governed by PDEs and (possibly time-delay ordinary differential equations such as, for example, models of machining processes.

  7. Refrigerating fluids; Fluides frigorigenes

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1999-03-01

    Refrigerating fluids are experiencing a real revolution since few years. CFCs with their destructive effect on the ozone layer are now prohibited while HCFCs will be progressively eliminated and replaced by HFCs. However, HFCs can contribute to the increase of the greenhouse effect. The solutions proposed by thermal engineering professionals consist in the confinement of air-conditioning installations (elimination of recurrent leaks) and in the improvement of installations efficiency. HCFC fluids like the R 22 are still widely used in air-conditioning but they are supposed to be replaced by HFC fluids like the R 134a, the R 407C or the R 410A. This short paper gives a brief presentation of these fluids and of their chemical characteristics. (J.S.)

  8. Advanced Thermal Status Control of Crews in EVA and Escape Suits

    Science.gov (United States)

    Koscheyev, V. S.; Coca, A.; Leon, G. R.

    Over the course of the manned space program, there has been an accumulation of experience on methods to control the thermal status of astronauts in open space. However, there remains a significant need for a simple method to monitor the astronaut's level of heat exchange during EVA, particularly in an emergency period, or during crew escape. The liquid cooling/warming tubing system that covers the body surface creates considerable complexity for evaluating the body's overall thermal response. Moreover, the methods used to monitor core temperature (Tc) are problematic in regard to their invasiveness and accuracy. NASA is currently attempting to develop a unified methodology for protection during EVA and crew escape that would necessarily include the control of astronaut thermal status. The findings from our research program have significant implications for solving this still-vexing problem. Our experimental paradigm centers on the assessment of thermodynamic processes with subjects donned in a specially designed symmetrically divided multi-compartment liquid cooling/warming garment consisting of 16 zones, 8 on each side of the body (hands, forearms, shoulders, torso, head, thighs, calves and feet). This garment configuration enables the study of heat exchange under nonuniform temperatures on the body surface by systematically varying the proportions of nonuniform temperatures (warm/cold) in different experimental conditions. Tc was assessed by rectal (Tr), esophageal (Tes), and ear canal temperature (Tec). Skin temperature (Tsk) was measured by a total of 26 sensors placed symmetrically on the left and right sides of the body, the main magistral vessels (carotid, brachial, femoral), and local vessel networks. We paid particular attention to the thermal status of the fingers by measuring blood perfusion, temperature (Tfing), heat flux, and thermal/comfort perception. The monitoring of Tfing and heat flux in different experimental conditions was highly informative

  9. Evaluation of some natural water-insoluble cellulosic material as lost circulation control additives in water-based drilling fluid

    Directory of Open Access Journals (Sweden)

    Ahmed Mohamed Alsabagh

    2015-12-01

    In this work, three natural water-insoluble cellulosic materials; peanut hulls, bagasse and sawdust were investigated as lost circulation control materials. One hundred and eight different LCM samples made of various materials were tested with mud. The experiments were conducted in a permeability plugging apparatus (PPA at a differential pressure of 100 psi and 300 psi, using 10, 60 and 90 ceramic discs. The performance of each LCM sample was determined based on the amount of spurt loss and total fluid loss of the mud according to the American Petroleum Institute (API standard. The obtained results showed that, the amount of the fluid loss depends on the LCM material, concentration and size distribution, testing results show that, the peanut gives the best results among the bagasse and sawdust, especially fine size which exhibited better results in the filtration characteristics due to the better filling properties of this size. Peanut hulls, bagasse and sawdust show a slight effect on the rheological properties of the mud. The results were discussed on light of particle size distribution.

  10. Controlled-source electromagnetic and seismic delineation of subseafloor fluid flow structures in a gas hydrate province, offshore Norway

    Science.gov (United States)

    Attias, Eric; Weitemeyer, Karen; Minshull, Tim A.; Best, Angus I.; Sinha, Martin; Jegen-Kulcsar, Marion; Hölz, Sebastian; Berndt, Christian

    2016-08-01

    Deep sea pockmarks underlain by chimney-like or pipe structures that contain methane hydrate are abundant along the Norwegian continental margin. In such hydrate provinces the interaction between hydrate formation and fluid flow has significance for benthic ecosystems and possibly climate change. The Nyegga region, situated on the western Norwegian continental slope, is characterized by an extensive pockmark field known to accommodate substantial methane gas hydrate deposits. The aim of this study is to detect and delineate both the gas hydrate and free gas reservoirs at one of Nyegga's pockmarks. In 2012, a marine controlled-source electromagnetic (CSEM) survey was performed at a pockmark in this region, where high-resolution 3-D seismic data were previously collected in 2006. 2-D CSEM inversions were computed using the data acquired by ocean bottom electrical field receivers. Our results, derived from unconstrained and seismically constrained CSEM inversions, suggest the presence of two distinctive resistivity anomalies beneath the pockmark: a shallow vertical anomaly at the underlying pipe structure, likely due to gas hydrate accumulation, and a laterally extensive anomaly attributed to a free gas zone below the base of the gas hydrate stability zone. This work contributes to a robust characterization of gas hydrate deposits within subseafloor fluid flow pipe structures.

  11. Safe, Non-Corrosive Dielectric Fluid for Stagnating Radiator Thermal Control System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Paragon proposes to develop a single-loop, non-toxic, stagnating active pumped loop thermal control design for NASA's Orion or Lunar Surface Access Module (LSAM)...

  12. Status of the array control and data acquisition system for the Cherenkov Telescope Array

    Science.gov (United States)

    Füßling, Matthias; Oya, Igor; Balzer, Arnim; Berge, David; Borkowski, Jerzy; Conforti, Vito; Colomé, Josep; Lindemann, Rico; Lyard, Etienne; Melkumyan, David; Punch, Michael; Schwanke, Ullrich; Schwarz, Joseph; Tanci, Claudio; Tosti, Gino; Wegner, Peter; Wischnewski, Ralf; Weinstein, Amanda

    2016-08-01

    The Cherenkov Telescope Array (CTA) will be the next-generation ground-based observatory using the atmospheric Cherenkov technique. The CTA instrument will allow researchers to explore the gamma-ray sky in the energy range from 20 GeV to 300 TeV. CTA will comprise two arrays of telescopes, one with about 100 telescopes in the Southern hemisphere and another smaller array of telescopes in the North. CTA poses novel challenges in the field of ground-based Cherenkov astronomy, due to the demands of operating an observatory composed of a large and distributed system with the needed robustness and reliability that characterize an observatory. The array control and data acquisition system of CTA (ACTL) provides the means to control, readout and monitor the telescopes and equipment of the CTA arrays. The ACTL system must be flexible and reliable enough to permit the simultaneous and automatic control of multiple sub-arrays of telescopes with a minimum effort of the personnel on-site. In addition, the system must be able to react to external factors such as changing weather conditions and loss of telescopes and, on short timescales, to incoming scientific alerts from time-critical transient phenomena. The ACTL system provides the means to time-stamp, readout, filter and store the scientific data at aggregated rates of a few GB/s. Monitoring information from tens of thousands of hardware elements need to be channeled to high performance database systems and will be used to identify potential problems in the instrumentation. This contribution provides an overview of the ACTL system and a status report of the ACTL project within CTA.

  13. Development of a fluid bed granulation process control strategy based on real-time process and product measurements.

    Science.gov (United States)

    Burggraeve, Anneleen; Silva, Ana F T; Van den Kerkhof, Tom; Hellings, Mario; Vervaet, Chris; Remon, Jean Paul; Vander Heyden, Yvan; De Beer, Thomas

    2012-10-15

    This article describes the results of three case studies conducted consecutively, in order to develop a process control strategy for a top-spray fluid bed granulation process. The use of several real-time particle size (i.e., spatial filter velocimetry and focused beam reflectance measurement) and moisture (i.e., near infrared (NIR) and Lighthouse near infrared spectroscopy) analyzers was examined. A feed-forward process control method was developed, where in-line collected granulation information during the process spraying phase was used to determine the optimum drying temperature of the consecutive drying phase. Via real-time monitoring of process (i.e., spraying temperature and spray rate) and product (i.e., granule size distribution and moisture) parameters during the spraying period, the batch bulk density was predicted at the end of the spraying cycle, using a PLS model. When this predicted bulk density was not meeting the desired value, the developed control method allowed the calculation of an adjusted drying temperature leading to the desired batch bulk density at the end of the granulation process. Besides the development of the feed-forward control strategy, a quantitative PLS model for in-line moisture content prediction of the granulated end product was built using the NIR data.

  14. Optimal Control of Magnetorheological Fluid Dampers for Seismic Isolation of Structures

    Directory of Open Access Journals (Sweden)

    Ameen H. El-Sinawi

    2013-01-01

    Full Text Available This paper presents the modeling and control of a magnetorheological (MR damper, installed in Chevron configuration, at the base of a 20-story benchmark building. The building structural model is created using the commercial software package ETABS. The MR damper model is derived from Bouc-Wen hysteresis model which provides the critical nonlinear dynamics that best represents the MR damper under a wide range of operating conditions. System identification is used to derive a low-order nonlinear model that best mimics the nonlinear dynamics of the actual MR damper. Dynamic behavior of this low-order model is tested and validated over a range of inputs. The damper model has proven its validity to a high degree of accuracy against the nonlinear model. A Kalman filter is designed to best estimate the state of the structure-damper system for feedback implementation purposes. Using the estimated states, an LQG-based compensator is designed to control the MR damper under earthquake loads. To demonstrate the effectiveness of this control strategy, four historical earthquakes are applied to the structure. Controlled and uncontrolled floor accelerations and displacements at key locations are compared. Results of the optimally controlled model demonstrate superior performance in comparison to the uncontrolled model.

  15. Advanced Outage and Control Center: Strategies for Nuclear Plant Outage Work Status Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Gregory Weatherby

    2012-05-01

    The research effort is a part of the Light Water Reactor Sustainability (LWRS) Program. LWRS is a research and development program sponsored by the Department of Energy, performed in close collaboration with industry to provide the technical foundations for licensing and managing the long-term, safe and economical operation of current nuclear power plants. The LWRS Program serves to help the US nuclear industry adopt new technologies and engineering solutions that facilitate the continued safe operation of the plants and extension of the current operating licenses. The Outage Control Center (OCC) Pilot Project was directed at carrying out the applied research for development and pilot of technology designed to enhance safe outage and maintenance operations, improve human performance and reliability, increase overall operational efficiency, and improve plant status control. Plant outage management is a high priority concern for the nuclear industry from cost and safety perspectives. Unfortunately, many of the underlying technologies supporting outage control are the same as those used in the 1980’s. They depend heavily upon large teams of staff, multiple work and coordination locations, and manual administrative actions that require large amounts of paper. Previous work in human reliability analysis suggests that many repetitive tasks, including paper work tasks, may have a failure rate of 1.0E-3 or higher (Gertman, 1996). With between 10,000 and 45,000 subtasks being performed during an outage (Gomes, 1996), the opportunity for human error of some consequence is a realistic concern. Although a number of factors exist that can make these errors recoverable, reducing and effectively coordinating the sheer number of tasks to be performed, particularly those that are error prone, has the potential to enhance outage efficiency and safety. Additionally, outage management requires precise coordination of work groups that do not always share similar objectives. Outage

  16. Iron Status and Febrile Seizure- A Case Control Study in Children Less Than 3 Years

    Directory of Open Access Journals (Sweden)

    Mansour SADEGHZADEH

    2013-01-01

    Full Text Available  How to cite this article: Sadeghzadeh M, Khoshnevis P, Mahboubi E. Iron Status and Febrile Seizure- A Case Control Study in Children Less Than 3 Years. Iran J Child Neurol Autumn 2012; 6(4:27-31.Abstract Objective: Febrile seizure is one of the most common neurological conditions of childhood. Several theories, such as iron deficiency anemia have been proposed as the pathogenesis of this condition. The aim of this study was to find the association between iron deficiency anemia and febrile seizures in children aged 6 months to 3 years admitted in Valie Asr hospital in Zanjan. Materials &Methods Hemoglobin (Hb, mean corpuscular volume (MCV, serum iron (SI, total iron binding capacity (TIBC and SI/TIBC ratio were assessed in one hundred children with febrile seizures and compared to the values of one hundred healthy children presenting in a heath care center in the same period as the control group. Results A total of 6% of cases had iron deficiency anemia which was similar to the control group. In the case group SI/TIBC ratio below 12% was seen in 58% of children which was significantly higher than that of the control group (29%. Conclusion The results of this study suggest that although anemia was not common among febrile seizure patients, iron deficiency was more frequent in these patients. ReferencesBidabadi E, Mashouf M.. Association between iron deficiency anemia and first febrile convulsion: A case-control study. Seizure. 2009 Jan;18(5:347-51.Sadeghzadeh M, Khoshnevisasl P, Moussavinassab N, Koosha A, Norouzi M. The Relation Between Serum Zinc Level and Febrile Seizures in Children Admitted to Zanjan Valie-Asr Hospital. J Zanjan Uni Med Sci. 2011;19(74:17-24.Kumari PL, Nair MK, Nair SM, Kailas L, Geetha S. Iron deficiency as a risk factor for simple febrile seizures-a case control study. Indian Pediatr. 2012 Jan;49(1:17-9.Pisacane A, Sansone R, Impagliazzo N, Coppola A, Rolando P, D'Apuzzo A, Tregrossi C. Iron deficiency anaemia and

  17. Use of fluid injection of Krylamin D for control of water influx to underground workings

    Energy Technology Data Exchange (ETDEWEB)

    Postawa, J.; Stryczek, S.; Rakoczy, W.

    1987-05-01

    Water influx to a 270 m deep mine roadway in the Jaworzno black coal mine is associated with a tectonic fault. Injection of Krylamin D urea-formaldehyde resin was used to control water influx. Injection boreholes, 42 mm in diameter, were drilled perpendicular to the roadway axis. Resin consumption rate ranged from 50-150 dm/sup 3/ in coal to 30-80 dm/sup 3/ in shales. About 5 t of resin were used for water influx control in a 5.0 m long roadway section. Resin injection equipment and distribution of injection boreholes are discussed.

  18. Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing.

    Science.gov (United States)

    Tandon, Vishal; Kang, Woo Seok; Robbins, Tremaan A; Spencer, Abigail J; Kim, Ernest S; McKenna, Michael J; Kujawa, Sharon G; Fiering, Jason; Pararas, Erin E L; Mescher, Mark J; Sewell, William F; Borenstein, Jeffrey T

    2016-03-07

    The anatomical and pharmacological inaccessibility of the inner ear is a major challenge in drug-based treatment of auditory disorders. This also makes pharmacokinetic characterization of new drugs with systemic delivery challenging, because efficacy is coupled with how efficiently a drug can reach its target. Direct delivery of drugs to cochlear fluids bypasses pharmacokinetic barriers and helps to minimize systemic toxicity, but anatomical barriers make administration of multiple doses difficult without an automated delivery system. Such a system may be required for hair-cell regeneration treatments, which will likely require timed delivery of several drugs. To address these challenges, we have developed a micropump for controlled, automated inner-ear drug delivery with the ultimate goal of producing a long-term implantable/wearable delivery system. The current pump is designed to be used with a head mount for guinea pigs in preclinical drug characterization experiments. In this system, we have addressed several microfluidic challenges, including maintaining controlled delivery at safe, low flow rates and delivering drug without increasing the volume of fluid in the cochlea. By integrating a drug reservoir and all fluidic components into the microfluidic structure of the pump, we have made the drug delivery system robust compared to previous systems that utilized separate, tubing-connected components. In this study, we characterized the pump's unique infuse-withdraw and on-demand dosing capabilities on the bench and in guinea pig animal models. For the animal experiments, we used DNQX, a glutamate receptor antagonist, as a physiological indicator of drug delivery. DNQX suppresses compound action potentials (CAPs), so we were able to infer the distribution and spreading of the DNQX over time by measuring the changes in CAPs in response to stimuli at several characteristic frequencies.

  19. Control of low Reynolds number flows by means of fluid-structure interactions

    Science.gov (United States)

    Gursul, I.; Cleaver, D. J.; Wang, Z.

    2014-01-01

    There is great interest in small aircraft known as Micro Air Vehicles and mini Unmanned Air Vehicles due to the wide range of possible applications. This article reviews recent work that aims to exploit the flexibility of the wing structure in order to increase lift and thrust, and delay stall. Wing flexibility has often been considered to be unwanted for large conventional aircraft and measures are taken to limit the deformation. In contrast, very small aircraft flying at low speeds are not necessarily subject to the same limitation. This approach is only applicable to small aircraft because the frequencies of the wing structure and fluid flow instabilities are close to each other. Consequently, small amplitude and high-frequency motions will be considered. We first start with rigid airfoils and wings in forced plunging motion, which mimics the bending oscillations. The main advantage of this approach is the freedom to vary the frequency within a wide range. Two mechanisms of high-lift production on the oscillating rigid airfoils are discussed. In the first one, leading-edge vortex dynamics and different modes of vortex topology play an important role on the time-averaged lift and thrust at post-stall angles of attack. Existence of optimal frequencies and amplitudes are demonstrated, and their relation to other phenomena is discussed. In the second mechanism of high-lift, trailing-edge vortex dynamics leads to bifurcated/asymmetric flows at pre-stall angles of attack. Deflected wakes can lead to time-averaged lift coefficients higher than those for the first mechanism. Some aspects of lift enhancement can be sensitive to the airfoil shape. For three-dimensional finite wings, lift enhancement due to the leading-edge vortices and existence of optimal frequencies are similar to the two-dimensional case. Vortex dynamics of the leading-edge vortex and tip vortex is discussed in detail. Leading-edge sweep is shown to be beneficial in the reattachment of the separated

  20. Morphine and codeine in oral fluid after controlled poppy seed administration.

    Science.gov (United States)

    Concheiro, Marta; Newmeyer, Matthew N; da Costa, Jose Luiz; Flegel, Ron; Gorelick, David A; Huestis, Marilyn A

    2015-07-01

    Opiates are an important drug class in drug testing programmes. Ingestion of poppy seeds containing morphine and codeine can yield positive opiate tests and mislead result interpretation in forensic and clinical settings. Multiple publications evaluated urine opiate concentrations following poppy seed ingestion, but only two addressed oral fluid (OF) results; neither provided the ingested morphine and codeine dosage. We administered two 45 g raw poppy seed doses, each containing 15.7 mg morphine and 3.1 mg codeine, 8 h apart to 17 healthy adults. All OF specimens were screened by on-site OF immunoassay Draeger DrugTest 5000, and confirmed with OF collected with Oral-Eze® device and quantified by liquid chromatography-tandem mass spectrometry (1 µg/L morphine and codeine limits of quantification). Specimens (n = 459) were collected before and up to 32 h after the first dose. All specimens screened positive 0.5 h after dosing and remained positive for 0.5-13 h at Draeger 20 µg/L morphine cut-off. Maximum OF morphine and codeine concentrations (Cmax ) were 177 and 32.6 µg/L, with times to Cmax (Tmax ) of 0.5-1 h and 0.5-2.5 h post-dose, respectively. Windows of detection after the second dose extended at least 24 h for morphine and to 18 h for codeine. After both doses, the last morphine positive OF result was 1 h with 40 µg/L 2004 proposed US Substance Abuse and Mental Health Services Administration cut-off, and 0.5 h with 95 µg/L cut-off, recently recommended by the Driving under the Influence of Drugs and Medicines project. Positive OF morphine results are possible 0.5-1 h after ingestion of 15.7 mg of morphine in raw poppy seeds, depending on the cut-off employed.

  1. Working memory and fluid intelligence: capacity, attention control, and secondary memory retrieval.

    Science.gov (United States)

    Unsworth, Nash; Fukuda, Keisuke; Awh, Edward; Vogel, Edward K

    2014-06-01

    Several theories have been put forth to explain the relation between working memory (WM) and gF. Unfortunately, no single factor has been shown to fully account for the relation between these two important constructs. In the current study we tested whether multiple factors (capacity, attention control, and secondary memory) would collectively account for the relation. A large number of participants performed multiple measures of each construct and latent variable analyses were used to examine the data. The results demonstrated that capacity, attention control, and secondary memory were uniquely related to WM storage, WM processing, and gF. Importantly, the three factors completely accounted for the relation between WM (both processing and storage) and gF. Thus, although storage and processing make independent contributions to gF, both of these contributions are accounted for by variation in capacity, attention control and secondary memory. These results are consistent with the multifaceted view of WM, suggesting that individual differences in capacity, attention control, and secondary memory jointly account for individual differences in WM and its relation with gF.

  2. Plasma, oral fluid and sweat wipe ecstasy concentrations in controlled and real life conditions

    NARCIS (Netherlands)

    Samyn, N; De Boeck, G; Wood, M; Lamers, CTJ; De Waard, D; Brookhuis, KA; Verstraete, AG; Riedel, WJ

    2002-01-01

    In a double-blind placebo controlled study on psychomotor skills important for car driving (Study 1), a 75 mg dose of 3,4methylenedioxymethamphetamine (MDMA) was administered orally to 12 healthy Volunteers who were known to be recreational MDMA-users. Toxicokinetic data were gathered by analysis of

  3. Nonflammable coolants for space vehicle environmental control systems Compatibility of component materials with selected dielectric fluids.

    Science.gov (United States)

    Howard, R. T.; Korpolinski, T. S.; Mace, E. W.

    1971-01-01

    This paper summarizes a 4-year effort to evaluate and implement a nonflammable substitute coolant for application in the Saturn instrument unit (IU) environmental control system (ECS). Discussed are candidate material evaluations, detailed investigations of the properties of the coolant selected, and a summary of the implementation into a flight vehicle.

  4. A Parent-Directed Language Intervention for Children of Low Socioeconomic Status: A Randomized Controlled Pilot Study

    Science.gov (United States)

    Suskind, Dana L.; Leffel, Kristin R.; Graf, Eileen; Hernandez, Marc W.; Gunderson, Elizabeth A.; Sapolich, Shannon G.; Suskind, Elizabeth; Leininger, Lindsey; Goldin-Meadow, Susan; Levine, Susan C.

    2016-01-01

    We designed a parent-directed home-visiting intervention targeting socioeconomic status (SES) disparities in children's early language environments. A randomized controlled trial was used to evaluate whether the intervention improved parents' knowledge of child language development and increased the amount and diversity of parent talk.…

  5. Guided imagery in people with fibromyalgia: a randomized controlled trial of effects on pain, functional status and self-efficacy.

    NARCIS (Netherlands)

    Verkaik, R.; Busch, M.; Koeneman, T.; Berg, R. van den; Spreeuwenberg, P.; Francke, A.L.

    2014-01-01

    Studies on the effects of guided imagery in patients with fibromyalgia show varying results. This randomized controlled trial (n = 65) aims to give more insight into the effects on pain, functional status, and self-efficacy. Daily pain was assessed with a pain diary using a Visual Analogue Scale. Fu

  6. [Analysis of interdependence of temperament, neuroendocrine control and psychophysiological status during dry immersion].

    Science.gov (United States)

    Nichiporuk, I A

    2008-01-01

    Interdependence of temperament, hormonal and psychophysiological status was investigated in 8 young volunteers for 7-d dry immersion (DI). Blood levels of insulin, sex, steroid, thyroid hormones and psychomotor parameters were determined on DI days 3 and 7, and on day 7 of recovery. Before DI, the volunteers filled in the Kettelle personality questionnaire. During DI, anxious subjects spent less time to compare visual patterns demonstrating high and stable speed of reactions but made a bit more errors. Extraverts showed high speed of reactions and stability of psychomotor parameters and did not increase the number of errors. Easy-tempered and introvert subjects preserved inherently high insulin concentrations in DI. Support deprivation was attended by drop of the levels of triiodothyronine and cortisol and rise of prolactin and thyroxin. Results of multiple correlation analysis led to the conclusion that DI accentuates the role of original extra-introversion and dampens origin anxiety. Successfulness can be attained by adequate alteration of the levels of steroid and thyroid hormones with effectively balanced vagoinsulin-sympathoadrenal neuroendocrine control and monoaminergic CNV activity.

  7. A Study of Heavy Metal Pollution in China: Current Status, Pollution-Control Policies and Countermeasures

    Directory of Open Access Journals (Sweden)

    Hui Hu

    2014-09-01

    Full Text Available In the past 30 years, China’s economy has experienced rapid development, which led to a vast increase in energy consumption and serious environmental pollution. Among the different types of pollution, heavy metal pollution has become one of the major environmental issues in China. A number of studies show that high level of heavy metal exposure is a frequent cause of permanent intellectual and developmental disabilities. In recent years, some traditional pollutants, such as sulfur dioxide and carbon dioxide, have been put under control in China. However, heavy metal pollution, which poses even greater risks to public health and sustainable development, has yet to gain policymakers’ attention. The purpose of this paper is to explore effective countermeasures for heavy metal pollution in China. The present study reviews the current status of China’s heavy metal pollution and analyzes related public policies and countermeasures against that pollution. It also presents a few recommendations and measures for prevention of heavy metal pollution.

  8. Preoperative controlling nutritional status (CONUT) is useful to estimate the prognosis after esophagectomy for esophageal cancer.

    Science.gov (United States)

    Yoshida, Naoya; Harada, Kazuto; Baba, Yoshifumi; Kosumi, Keisuke; Iwatsuki, Masaaki; Kinoshita, Koichi; Nakamura, Kenichi; Sakamoto, Yasuo; Miyamoto, Yuji; Karashima, Ryuichi; Mima, Kosuke; Sawayama, Hiroshi; Ohuchi, Mayuko; Chikamoto, Akira; Imamura, Yu; Watanabe, Masayuki; Baba, Hideo

    2017-03-01

    The aim of this study is to confirm the predictive value of controlling nutritional status (CONUT), as a postoperative prognostic marker for esophageal cancer patients undergoing esophagectomy. We retrospectively analyzed 373 patients who underwent three-incision esophagectomy with 2- or 3-field lymphadenectomy for esophageal cancer between April 2005 and March 2016. The patients were divided into three groups based on the degree of preoperative malnutrition as assessed by CONUT: normal, light malnutrition, and moderate or severe malnutrition. The patients with moderate or severe malnutrition experienced a significantly higher frequency of reoperation (normal or light malnutrition, 6.3%; moderate or severe malnutrition, 18.2%; P = 0.033) and a higher tendency for respiratory morbidities (normal or light malnutrition, 14.0%; moderate or severe malnutrition, 27.3%; P = 0.088). Cox regression analysis identified a significantly poor prognosis, in both overall survival (hazard ratio (HR), 3.56; 95% confidence interval (CI), 1.714-7.390; P cancer-specific survival (HR, 3.41; 95% CI, 1.790-6.516; P = 0.046). CONUT is convenient and useful for preoperatively assessing malnutrition and prognosis of esophageal cancer patients who underwent surgery.

  9. Current status and strategies for the control of viral hepatitis A in Korea.

    Science.gov (United States)

    Yoon, Eileen L; Sinn, Dong Hyun; Lee, Hyun Woong; Kim, Ji Hoon

    2017-09-01

    Hepatitis A virus is one of the most frequent causes of foodborne infection, which is closely associated with sanitary conditions and hygienic practices. The clinical spectrum of acute hepatitis A is wide, ranging from mild case without any noticeable symptoms to severe case with acute liver failure leading to mortality. The severity and outcome are highly correlated with age at infection. In developing countries, most people are infected in early childhood without significant symptom. Ironically, in area where sanitary condition has improved rapidly, adults who do not have immunity for viral hepatitis A (VH-A) in early childhood is accumulating. Adults without immunity are exposed to risks of symptomatic disease and large outbreaks in society. In Korea, where hygiene has improved rapidly, acute hepatitis A is a significant health burden that needs to be managed with nationwide health policy. The incidence of symptomatic VH-A has increased since 2000 and peaked in 2009. Korea has designated hepatitis A as a group 1 nationally notifiable infectious disease in 2001. Since 2001, mandatory surveillance system has been established to detect every single case of acute hepatitis A. Universal, nationwide vaccination program for newborns was introduced in 2015. In this review, we will present the current epidemiologic status of viral hepatitis A, and evaluate the effectiveness of the current nationwide strategies for the control of viral hepatitis A in Korea. Furthermore, we presented some action proposals that can help eliminate viral hepatitis A, which is a significant health burden in Korea.

  10. Risk Factors for Febrile Status Epilepticus: A Case-Control Study

    Science.gov (United States)

    Hesdorffer, Dale C.; Shinnar, Shlomo; Lewis, Darrell V.; Nordli, Douglas R.; Pellock, John M.; Moshé, Solomon L.; Shinnar, Ruth C.; Litherland, Claire; Bagiella, Emilia; Frank, L. Matthew; Bello, Jacqueline A.; Chan, Stephen; Masur, David; MacFall, James; Sun, Shumei

    2013-01-01

    Objective To identify risk factors for developing a first febrile status epilepticus (FSE) among children with a first febrile seizure (FS). Study design Cases were children with a first FS that was FSE drawn from the Consequences of Prolonged Febrile Seizures in Childhood and Columbia cohorts. Controls were children with a first simple FS and separately, children with a first complex FS that was not FSE. Identical questionnaires were administered to family members of the 3 cohorts. Magnetic resonance imaging protocol and readings were consistent across cohorts, and seizure phenomenology was assessed by the same physicians. Risk factors were analyzed using logistic regression. Results Compared with children with simple FS, FSE was associated with younger age, lower temperature, longer duration (1-24 hours) of recognized temperature before FS, female sex, structural temporal lobe abnormalities, and first-degree family history of FS. Compared with children with other complex FS, FSE was associated with low temperature and longer duration (1-24 hours) of temperature recognition before FS. Risk factors for complex FS that was not FSE were similar in magnitude to those for FSE but only younger age was significant. Conclusions Among children with a first FS, FSE appears to be due to a combination of lower seizure threshold (younger age and lower temperatures) and impaired regulation of seizure duration. Clinicians evaluating FS should be aware of these factors as many episodes of FSE go unnoticed. Further work is needed to develop strategies to prevent FSE. PMID:23809042

  11. Oral lesions and dental status among institutionalized orphans in Yemen: A matched case-control study

    Directory of Open Access Journals (Sweden)

    Sadeq Ali Al-Maweri

    2014-01-01

    Full Text Available Objectives: The aim of this study was to assess the prevalence of oral mucosal lesions (OMLs and dental caries and to evaluate oral health practices among institutionalized orphan-children in Sana′a city, Yemen. Subjects and Methods: A sample of 202 institutionalized male-orphan-children in the main orphanage in Sana′a city, were matched to 202 non-orphan schoolchildren. Clinical examination included assessment of OMLs based on standard international diagnostic criteria and evaluation of dental status using the Decayed/decayed, Missed/missed and Filled/filled (DMFT/dmft index according to World Health Organization recommendations. Demographic data and oral hygiene practices were obtained by interviewing each subject using special questionnaire form. Results: Majority of children were in the 12-15 year age group. Nine types of lesions were reported among orphans; the most common lesions were fissured tongue (24.3%, herpes labialis (7.9% and traumatic ulcers (2.5%. The occurrence of herpes labialis was found to be significantly higher in orphans than in controls (P < 0.01. The prevalence of dental caries was insignificantly lower among the orphans (84.7% compared with the non-orphans (89.61%; P = 0.136. The mean dmft score was significantly lower in orphans than in controls (2.28 vs. 3.82; P = 0.001. Conclusions: The institutionalized children in this orphanage had a high prevalence of OMLs but low prevalence of dental caries, though they revealed poor oral hygiene practices. Effective oral health promotion strategies need to be implemented to improve the oral health and oral health practices of children living in orphanages.

  12. Children's Social Status as a Function of Emotionality and Attention Control

    Science.gov (United States)

    Schultz, David; Izard, Carroll E.; Stapleton, Laura M.; Buckingham-Howes, Stacy; Bear, George A.

    2009-01-01

    A recent meta-analysis found that across studies individual differences in aspects of children's emotionality predict social status [Dougherty, L.R., (2006). Children's emotionality and social status: a meta-analytic review. Social Development, 15, 394-417.]. In the present study we extended these findings by examining the emotion of interest and…

  13. Effects of limiting fluid intake on clinical and laboratory outcomes in patients with heart failure. Results of a meta-analysis of randomized controlled trials.

    Science.gov (United States)

    De Vecchis, R; Baldi, C; Cioppa, C; Giasi, A; Fusco, A

    2016-02-01

    The guidelines of the Scientific Societies of Cardiology recommend limiting fluid intake as a nonpharmacological measure for the management of chronic heart failure (HF). However, many patients with HF may suffer from severe thirst. A meta-analysis was performed to evaluate the effect of limiting fluid consumption based on various clinical and laboratory outcomes in patients with chronic HF. Only randomized controlled trials comparing liberal and restricted fluid oral intake in patients with HF were included. Primary outcomes were HF hospitalizations and all-cause mortality. Secondary outcomes were the sensation of thirst, the duration of therapy with intravenous diuretics, and the serum levels of creatinine, sodium, and B-type natriuretic peptide (BNP). Six studies met the inclusion criteria. Significant heterogeneity was detected for the majority of outcomes. In 5 studies, patients with restricted fluid intake compared to patients with free consumption of beverages had similar rehospitalization and mortality rates. There were no differences regarding patients' sense of thirst (4 studies), duration of intravenous diuretic treatment (2 studies), serum creatinine levels (5 studies), and serum sodium levels (5 studies). Serum BNP levels were significantly higher in the group with free fluid intake (4 studies). In patients with HF, liberal fluid consumption does not seem to exert an unfavorable impact on HF rehospitalizations or all-cause mortality. Further randomized controlled trials are warranted to definitively confirm the present findings.

  14. Perceived Health Locus of Control, Self-Esteem, and Its Relations to Psychological Well-Being Status in Iranian Students

    OpenAIRE

    Moshki, M; H Ashtarian

    2010-01-01

    Background: Health locus of control (HLC) has been associated with a variety of ailments and health outcomes and de­signed to predict behaviors and cognitive processes relevant to mental and physical health. This study investigated the relation­ships between perceived health locus of control, self-esteem, and mental health status among Iranian students. Methods: In this analytical study the subjects were recruited from students in Gonabad University of Medical Sci­ence...

  15. Association of dental and periodontal status with bisphosphonate-related osteonecrosis of the jaws. A retrospective case controlled study

    OpenAIRE

    Kos, Marcin

    2014-01-01

    Introduction To assess the association of oral hygiene, dental caries, and periodontal status with bisphosphonate-related osteonecrosis of the jaws. Material and methods A retrospective case-control study on 81 patients treated for neoplasms with bone metastases. Twenty-nine patients with bone necrosis and 52 controls treated with bisphosphonates were compared using the Oral Hygiene Index, Decay, Missing, Filled Teeth, Community Periodontal Index of Treatment Needs, and Residual Periodontal B...

  16. Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects.

    Science.gov (United States)

    Carpenter, Linda L; Tyrka, Audrey R; McDougle, Christopher J; Malison, Robert T; Owens, Michael J; Nemeroff, Charles B; Price, Lawrence H

    2004-04-01

    Previous studies have reported elevated concentrations of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) in patients with major depression. Elevations of CSF CRF have also been reported in adult laboratory animals exposed to the stress of brief maternal deprivation or maternal neglect in the neonatal or preweaning period. The present study was designed to determine whether major depression and a history of perceived early adversity in childhood are independently associated with elevated CSF CRF concentrations in adults. In this case-control study, 27 medication-free adults with major depression and 25 matched controls underwent standardized lumbar puncture for collection of a single CSF sample at 1200. Subjects provided data about significant adverse early-life experiences and rated their global perceived level of stress during pre-school and preteen years on a six-point Likert scale. The mean difference in CSF CRF between depressed patients and controls did not reach statistical significance. In a regression model, perceived early-life stress was a significant predictor of CSF CRF, but depression was not. Perinatal adversity and perceived adversity in the preteen adversity years (ages 6-13 years) were both independently associated with decreasing CSF CRF concentrations. The relationship observed between perceived early-life stress and adult CSF CRF concentrations in this study closely parallels recent preclinical findings. More work is needed to elucidate the critical nature and timing of early events that may be associated with enduring neuroendocrine changes in humans.

  17. Computational fluid dynamics model of avian tracheal temperature control as a model for extant and extinct animals.

    Science.gov (United States)

    Sverdlova, N S; Arkali, F; Witzel, U; Perry, S F

    2013-10-01

    Respiratory evaporative cooling is an important mechanism of temperature control in bird. A computational simulation of the breathing cycle, heat and water loss in anatomical avian trachea/air sac model has not previously been conducted. We report a first attempt to simulate a breathing cycle in a three-dimensional model of avian trachea and air sacs (domestic fowl) using transient computational fluid dynamics. The airflow in the trachea of the model is evoked by changing the volume of the air sacs based on the measured tidal volume and inspiratory/expiratory times for the domestic fowl. We compare flow parameters and heat transfer results with in vivo data and with our previously reported results for a two-dimensional model. The total respiratory heat loss corresponds to about 13-19% of the starvation metabolic rate of domestic fowl. The present study can lend insight into a possible thermoregulatory function in species with long necks and/or a very long trachea, as found in swans and birds of paradise. Assuming the structure of the sauropod dinosaur respiratory system was close to avian, the simulation of the respiratory temperature control (using convective and evaporative cooling) in the extensively experimentally studied domestic fowl may also help in making simulations of respiratory heat control in these extinct animals. Copyright © 2013 Elsevier B.V. All rights reserved.

  18. An Experimental Investigation of the Acoustic and Fluid Dynamic Characteristics of a Circulation-Controlled Airfoil

    Science.gov (United States)

    2011-05-13

    sound production from a hydrofoil and identified three mechanisms: (1) low frequency curvature noise associated with interaction of a turbulent...2002). 2 Technical Approach A two-dimensional, dual-slotted, elliptic circulation control airfoil based on the hydrofoil studied by Rogers...airfoil, shown in Figure 1A, is designed based on the geometry of the hydrofoil previously studied by Rogers & Donnelly (2004). The airfoil’s profile

  19. Souring control in fluid samples of oil industry using a multiple ligand simultaneous docking (MLSD) strategy.

    Science.gov (United States)

    dos Santos, Elias Silva; de Souza, Leila Cristiane Virgens; de Assis, Patrícia Nascimento; de Almeida, Paulo Fernando; Ramos-de-Souza, Elias

    2015-01-01

    We have used docking techniques in order to propose potential inhibitors to the enzymes adenosine phosphosulfate reductase and adenosine triphosphate sulfurylase that are responsible, among other deleterious effects, for causing souring of oil and gas reservoirs. Three candidates selected through molecular docking revealed new and improved polar and hydrophobic interactions with the above-mentioned enzymes. Microbiological laboratory assays performed subsequently corroborated the results of computer modelling that the three compounds can efficiently control the biogenic sulfide production.

  20. Control of pore size and structure of tissue engineering scaffolds produced by supercritical fluid processing

    Directory of Open Access Journals (Sweden)

    H Tai

    2007-12-01

    Full Text Available Tissue engineering scaffolds require a controlled pore size and structure to host tissue formation. Supercritical carbon dioxide (scCO2 processing may be used to form foamed scaffolds in which the escape of CO2 from a plasticized polymer melt generates gas bubbles that shape the developing pores. The process of forming these scaffolds involves a simultaneous change in phase in the CO2 and the polymer, resulting in rapid expansion of a surface area and changes in polymer rheological properties. Hence, the process is difficult to control with respect to the desired final pore size and structure. In this paper, we describe a detailed study of the effect of polymer chemical composition, molecular weight and processing parameters on final scaffold characteristics. The study focuses on poly(DL-lactic acid (PDLLA and poly(DL-lactic acid-co-glycolic acid (PLGA as polymer classes with potential application as controlled release scaffolds for growth factor delivery. Processing parameters under investigation were temperature (from 5 to 55oC and pressure (from 60 to 230 bar. A series of amorphous PDLLA and PLGA polymers with various molecular weights (from 13 KD to 96 KD and/or chemical compositions (the mole percentage of glycolic acid in the polymers was 0, 15, 25, 35 and 50 respectively were employed. The resulting scaffolds were characterised by optical microscopy, scanning electron microscopy (SEM, and micro X-ray computed tomography (µCT. This is the first detailed study on using these series polymers for scaffold formation by supercritical technique. This study has demonstrated that the pore size and structure of the supercritical PDLLA and PLGA scaffolds can be tailored by careful control of processing conditions.

  1. Fluid-Mediated Stochastic Self-Assembly at Centimetric and Sub-Millimetric Scales: Design, Modeling, and Control

    Directory of Open Access Journals (Sweden)

    Bahar Haghighat

    2016-08-01

    Full Text Available Stochastic self-assembly provides promising means for building micro-/nano-structures with a variety of properties and functionalities. Numerous studies have been conducted on the control and modeling of the process in engineered self-assembling systems constituted of modules with varied capabilities ranging from completely reactive nano-/micro-particles to intelligent miniaturized robots. Depending on the capabilities of the constituting modules, different approaches have been utilized for controlling and modeling these systems. In the quest of a unifying control and modeling framework and within the broader perspective of investigating how stochastic control strategies can be adapted from the centimeter-scale down to the (sub-millimeter-scale, as well as from mechatronic to MEMS-based technology, this work presents the outcomes of our research on self-assembly during the past few years. As the first step, we leverage an experimental platform to study self-assembly of water-floating passive modules at the centimeter scale. A dedicated computational framework is developed for real-time tracking, modeling and control of the formation of specific structures. Using a similar approach, we then demonstrate controlled self-assembly of microparticles into clusters of a preset dimension in a microfluidic chamber, where the control loop is closed again through real-time tracking customized for a much faster system dynamics. Finally, with the aim of distributing the intelligence and realizing programmable self-assembly, we present a novel experimental system for fluid-mediated programmable stochastic self-assembly of active modules at the centimeter scale. The system is built around the water-floating 3-cm-sized Lily robots specifically designed to be operative in large swarms and allows for exploring the whole range of fully-centralized to fully-distributed control strategies. The outcomes of our research efforts extend the state-of-the-art methodologies

  2. [Development and evaluation of individualized fluid therapy in the elderly patients with coronary heart disease undergoing gastrointestinal surgery: a randomized, controlled trial].

    Science.gov (United States)

    Zheng, Hong; Guo, Hai; Ye, Jian-rong; Chen, Lin

    2012-06-01

    To develop and evaluate an individualized fluid therapy in the elderly patients with coronary heart disease undergoing gastrointestinal surgery. In this prospective study, 60 coronary heart disease patients undergoing gastrointestinal surgery were included in the First Affiliated Hospital of Xinjiang Medical University from March 2009 to March 2012. Patients were randomized into the intervention group and the control group with 30 patients in each group. Individualized fluid therapy was used during surgery and postoperative period in the ICU, which was determined based on target controlled fluid therapy according to cardiac index, stroke volume, and stroke volume variation. Traditional fluid therapy was used in the control group in the intraoperative and postoperative period. The two groups were compared in terms of postoperative hemodynamic parameters, total fluid volume, incidence of adverse cardiac events, and recovery of bowel function. Compared with the control group, mean arterial pressure was significantly increased at the commencement of the surgery. The cardiac index was significantly elevated during surgery and at the end of the surgery. Stroke volume was significantly increased after induction of anesthesia, during the surgery, and at the early stay of ICU period(all Pfluid volume, crystal usage, and urine were significantly less, while colloidal fluid use was significantly more in the intervention group as compared to the control group(all P0.05). In the intervention group, defecation time, time to first flatus, resumption of liquid intake, length of ICU stay and hospital stay were significantly less compared with the control group(Pfluid therapy can effectively decrease adverse cardiac events, improve postoperative gastrointestinal function, and reduce length of hospital stay.

  3. Amniotic fluid

    Science.gov (United States)

    ... carefully. Removing a sample of the fluid through amniocentesis can provide information about the sex, health, and development of the fetus. Images Amniocentesis Amniotic fluid Polyhydramnios Amniotic fluid References Cunningham FG, ...

  4. Developments in Fluid Power Control of Machinery and Manipulators (1 of 2)

    DEFF Research Database (Denmark)

    Conrad, Finn; Zarotti, Luca G.; Sørensen, Torben

    2000-01-01

    The paper presents objectives and results from the ESPRIT project SWING.The increasing competition on the world marked and the increasing public demands, requirements and regulations for protection of the environment are both driving forces and challenges for improving the development of control ...... and engineering design.The main aim of the SWING project is to improve the engineering design and product development cycle in SME's in the mechanical industry, and particulary in the hydraulic sector, through the introduction of best-practice using simulation and modelling IT-tools....

  5. Integrated Channel Selector for Directing Fluid Flow Using Thermoreversible Gelation Controlled by a Digital Mirror Device

    Directory of Open Access Journals (Sweden)

    Yoshitaka Shirasaki

    2013-01-01

    Full Text Available An integrated channel selector system employing thermoreversible gelation of a polymer was developed. Here, we show a system with 3×3 arrayed microchannels having nine crossing points. Infrared laser irradiation was used to form gel areas at several crossing points in arranging a flow path from the inlet to one of the nine outlets passing through certain junctions and channels. The multipoint irradiation by the infrared laser was realized using a personal-computer-controlled digital mirror device. The system was demonstrated to be able to direct flow to all nine outlets. Finally, we achieved to produce flexible paths for flowing particles including side trips.

  6. Oral health status of patients with acute coronary syndrome – a case control study

    Directory of Open Access Journals (Sweden)

    Ziebolz Dirk

    2012-06-01

    Full Text Available Abstract Background The aim of this investigation was to assess the state of oral health of patients with acute coronary syndrome (ACS and to compare this with that of a provably healthy control group (H. Methods 33 patients who were receiving treatment as inpatients following acute myocardial infarction or unstable angina pectoris took part in the study (ACS-group. A healthy control group (H-group made up of blood donors, was formed following matching for age, gender, and smoking habit with the study patient group. The dental investigation consisted of the dental status (DMF-T, a plaque-Index (PI, an assessment of gingival inflammation (GI and periodontal situation (Periodontal Screening Index: PSR®/PSI, and attachment loss (AL. Statistical evaluation: t-test, Mann–Whitney-test and chi- squared test (level of significance p  Results The mean DMF-T of the ACS-group (18.7 ± 6.8 and the H-group (19.4 ± 5.1 showed no difference (p = 0.7. Although, in the ACS-group the average loss of teeth (M-T: 8.4 ± 5.2 was higher than in the H-group (M-T: 5.8 ± 6.6 the difference was not significant (p = 0.2. Whereas with the PI no difference between the two groups was found (p = 0.9, the ACS-group showed significantly more signs of inflammation (GI than the H-group (p = 0.045. In the case of PSR®/PSI, there was no difference between the two groups (p = 0.7. With regard to AL, no difference was revealed between ACS- and H-group (p = 0.2. Conclusion Although, the state of oral health of the ACS-group differed only insignificantly from that of control, patients with ACS showed more signs of gingival inflammation and a higher loss of teeth.

  7. Computation of the Fluid and Optical Fields About the Stratospheric Observatory for Infrared Astronomy (SOFIA) and the Coupling of Fluids, Dynamics, and Control Laws on Parallel Computers

    Science.gov (United States)

    Atwood, Christopher A.

    1993-01-01

    The June 1992 to May 1993 grant NCC-2-677 provided for the continued demonstration of Computational Fluid Dynamics (CFD) as applied to the Stratospheric Observatory for Infrared Astronomy (SOFIA). While earlier grant years allowed validation of CFD through comparison against experiments, this year a new design proposal was evaluated. The new configuration would place the cavity aft of the wing, as opposed to the earlier baseline which was located immediately aft of the cockpit. This aft cavity placement allows for simplified structural and aircraft modification requirements, thus lowering the program cost of this national astronomy resource. Three appendices concerning this subject are presented.

  8. Role of α{sub 2}-adrenoceptors in the lateral parabrachial nucleus in the control of body fluid homeostasis

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, C.A.F.; Andrade-Franzé, G.M.F.; De Paula, P.M.; De Luca, L.A. Jr.; Menani, J.V. [Departamento de Fisiologia e Patologia, Faculdade de Odontologia, Universidade Estadual Paulista, Araraquara, SP (Brazil)

    2014-01-10

    Central α{sub 2}-adrenoceptors and the pontine lateral parabrachial nucleus (LPBN) are involved in the control of sodium and water intake. Bilateral injections of moxonidine (α{sub 2}-adrenergic/imidazoline receptor agonist) or noradrenaline into the LPBN strongly increases 0.3 M NaCl intake induced by a combined treatment of furosemide plus captopril. Injection of moxonidine into the LPBN also increases hypertonic NaCl and water intake and reduces oxytocin secretion, urinary sodium, and water excreted by cell-dehydrated rats, causing a positive sodium and water balance, which suggests that moxonidine injected into the LPBN deactivates mechanisms that restrain body fluid volume expansion. Pretreatment with specific α{sub 2}-adrenoceptor antagonists injected into the LPBN abolishes the behavioral and renal effects of moxonidine or noradrenaline injected into the same area, suggesting that these effects depend on activation of LPBN α{sub 2}-adrenoceptors. In fluid-depleted rats, the palatability of sodium is reduced by ingestion of hypertonic NaCl, limiting intake. However, in rats treated with moxonidine injected into the LPBN, the NaCl palatability remains high, even after ingestion of significant amounts of 0.3 M NaCl. The changes in behavioral and renal responses produced by activation of α{sub 2}-adrenoceptors in the LPBN are probably a consequence of reduction of oxytocin secretion and blockade of inhibitory signals that affect sodium palatability. In this review, a model is proposed to show how activation of α{sub 2}-adrenoceptors in the LPBN may affect palatability and, consequently, ingestion of sodium as well as renal sodium excretion.

  9. Lithologic Controls on Structure Highlight the Role of Fluids in Failure of a Franciscan Complex Accretionary Prism Thrust Fault

    Science.gov (United States)

    Bartram, H.; Tobin, H. J.; Goodwin, L. B.

    2015-12-01

    Plate-bounding subduction zone thrust systems are the source of major earthquakes and tsunamis, but their mechanics and internal structure remain poorly understood and relatively little-studied compared to faults in continental crust. Exposures in exhumed accretionary wedges present an opportunity to study seismogenic subduction thrusts in detail. In the Marin Headlands, a series of thrusts imbricates mechanically distinct lithologic units of the Mesozoic Franciscan Complex including pillow basalt, radiolarian chert, black mudstone, and turbidites. We examine variations in distribution and character of structure and vein occurrence in two exposures of the Rodeo Cove thrust, a fossil plate boundary exposed in the Marin Headlands. We observe a lithologic control on the degree and nature of fault localization. At Black Sand Beach, deformation is localized in broad fault cores of sheared black mudstone. Altered basalts, thrust over greywacke, mudstone, and chert, retain their coherence and pillow structures. Veins are only locally present. In contrast, mudstone is virtually absent from the exposure 2 km away at Rodeo Beach. At this location, deformation is concentrated in the altered basalts, which display evidence of extensive vein-rock interaction. Altered basalts exhibit a pervasive foliation, which is locally disrupted by both foliation-parallel and cross-cutting carbonate-filled veins and carbonate cemented breccia. Veins are voluminous (~50%) at this location. All the structures are cut by anastomosing brittle shear zones of foliated cataclasite or gouge. Analyses of vein chemistry will allow us to compare the sources of fluids that precipitated the common vein sets at Rodeo Beach to the locally developed veins at Black Sand Beach. These observations lead us to hypothesize that in the absence of a mechanically weak lithology, elevated pore fluid pressure is required for shear failure. If so, the vein-rich altered basalt at Rodeo Beach may record failure of an

  10. Types, Evolution and Pool-Controlling Significance of Pool Fluid Sources in Superimposed Basins: A Case Study from Paleozoic and Mesozoic in South China

    Institute of Scientific and Technical Information of China (English)

    Xu Sihuang; Mei Lianfu; Yuan Caiping; Ma Yongsheng; Guo Tonglou

    2007-01-01

    Having multiple tectonic evolution stages, South China belongs to a superimposed basin in nature. Most marine gas pools became secondary pools. The pool fluid sources serve as the principal pool-controlling factors. On the basis of eight typical petroleum pools, the type, evolution in time-space,and the controlling of petroleum distribution of pool fluid sources are comprehensively analyzed. The main types of pool fluid sources include hydrocarbon, generated primarily and secondly from source rocks, gas cracked from crude oil, gas dissolved in water, inorganic gas, and mixed gases. In terms of evolution, the primary hydrocarbon was predominant prior to Indosinian; during Indosinian to Yenshanian the secondary gas includes gas cracked from crude oil, gas generated secondarily, gas dissolved in water, and inorganic gas dominated; during Yenshanian to Himalayan the most fluid sources were mixed gases. Controlled by pool fluid sources, the pools with mixed gas sources distributed mainly in Upper Yangtze block, especially Sichuan (四川) basin; the pools with primary hydrocarbon sources distributed in paleo-uplifts such as Jiangnan (江南), but most of these pools became fossil pools; the pools with secondary hydrocarbon source distributed in the areas covered by Cretaceous and Eogene in Middle-Lower Yangtze blocks, and Chuxiong (楚雄), Shiwandashan (十万大山), and Nanpanjiang (南盘江) basins; the pools with inorganic gas source mainly formed and distributed in tensional structure areas.

  11. Analysis and control of the METC fluid-bed gasifier. Quarterly report, October 1994--January 1995

    Energy Technology Data Exchange (ETDEWEB)

    Farell, A.E.; Reddy, S.

    1995-03-01

    This document summarizes work performed for the period 10/1/94 to 2/1/95. The initial phase of the work focuses on developing a simple transfer function model of the Fluidized Bed Gasifier (FBG). This transfer function model will be developed based purely on the gasifier responses to step changes in gasifier inputs (including reactor air, convey air, cone nitrogen, FBG pressure, and coal feedrate). This transfer function model will represent a linear, dynamic model that is valid near the operating point at which the data was taken. In addition, a similar transfer function model will be developed using MGAS in order to assess MGAS for use as a model of the FBG for control systems analysis.

  12. MODELING OF SUPERCRITICAL FLUID EXTRACTION KINETIC OF FLAXSEED OIL BY DIFFUSION CONTROL METHOD

    Directory of Open Access Journals (Sweden)

    Emir Zafer HOŞGÜN

    2013-06-01

    Full Text Available In this study, Flaxseed oil was extracted by Supercritical Carbondioxide Extraction, and extractionkinetics was modelled using diffusion controlled method.The effect of process parameters, such as pressure (20, 35, 55 MPa, temperature (323 and 343 K, and CO2 flow rate (1 and 3 L CO2 /min on the extraction yield and effective diffusivity (De was investigated. The effective diffusion coefficient varied between 2.4 x10-12 and 10.8 x10-12 m2s-1 for the entire range of experiments and increased with the pressure and flow rate. The model fitted well theexperimental data (ADD varied between 2.35 and 7.48%.

  13. The Effects of Pilates Training on Balance Control and Self-Reported Health Status in Community-Dwelling Older Adults: A Randomized Controlled Trial.

    Science.gov (United States)

    Gabizon, Hadas; Press, Yan; Volkov, Ilia; Melzer, Itshak

    2016-07-01

    To evaluate the effect of a group-based Pilates training program on balance control and health status in healthy older adults. A single-blind, randomized, controlled trial. General community. A total of 88 community-dwelling older adults (age 71.15 ± 4.30 years), without evidence of functional balance impairment, were recruited and allocated at random to a Pilates intervention group (n = 44) or a control group (n = 44). The Pilates intervention group received 36 training sessions over three months (3 sessions a week), while the control group did not receive any intervention. Standing upright postural stability, performance-based measures of balance, and self-reported health status was assessed in both groups at baseline and at the end of the intervention period. Compared with the control group, the Pilates intervention did not improve postural stability, baseline functional measures of balance, or health status. The results suggest that because Pilates training is not task specific, it does not improve balance control or balance function in independent older adults.

  14. Node 3 Relocation Environmental Control and Life Support System Modification Kit Verification and Updated Status

    Science.gov (United States)

    Williams, David E.; Spector Lawrence N.

    2010-01-01

    Node 1 (Unity) flew to International Space Station (ISS) on Flight 2A. Node 1 was the first module of the United States On-Orbit Segment (USOS) launched to ISS. The Node 1 ISS Environmental Control and Life Support (ECLS) design featured limited ECLS capability. The main purpose of Node 1 was to provide internal storage by providing four stowage rack locations within the module and to allow docking of multiple modules and a truss segment to it. The ECLS subsystems inside Node 1 were routed through the element prior to launch to allow for easy integration of the attached future elements, particularly the Habitation Module which was planned to be located at the nadir docking port of Node 1. After Node I was on-orbit, the Program decided not to launch the Habitation Module and instead, to replace it with Node 3 (Tranquility). In 2007, the Program became concerned with a potential Russian docking port approach issue for the Russian FGB nadir docking port after Node 3 is attached to Node 1. To solve this concern the Program decided to relocate Node 3 from Node I nadir to Node 1 port. To support the movement of Node 3 the Program decided to build a modification kit for Node 1, an on-orbit feedthrough leak test device, and new vestibule jumpers to support the ECLS part of the relocation. This paper provides a design overview of the modification kit for Node 1, a summary of the Node 1 ECLS re-verification to support the Node 3 relocation from Node 1 nadir to Node 1 port, and a status of the ECLS modification kit installation into Node 1.

  15. Electrically Controllable Microparticle Synthesis and Digital Microfluidic Manipulation by Electric-Field-Induced Droplet Dispensing into Immiscible Fluids

    Science.gov (United States)

    Um, Taewoong; Hong, Jiwoo; Im, Do Jin; Lee, Sang Joon; Kang, In Seok

    2016-08-01

    The dispensing of tiny droplets is a basic and crucial process in a myriad of applications, such as DNA/protein microarray, cell cultures, chemical synthesis of microparticles, and digital microfluidics. This work systematically demonstrates droplet dispensing into immiscible fluids through electric charge concentration (ECC) method. It exhibits three main modes (i.e., attaching, uniform, and bursting modes) as a function of flow rates, applied voltages, and gap distances between the nozzle and the oil surface. Through a conventional nozzle with diameter of a few millimeters, charged droplets with volumes ranging from a few μL to a few tens of nL can be uniformly dispensed into the oil chamber without reduction in nozzle size. Based on the features of the proposed method (e.g., formation of droplets with controllable polarity and amount of electric charge in water and oil system), a simple and straightforward method is developed for microparticle synthesis, including preparation of colloidosomes and fabrication of Janus microparticles with anisotropic internal structures. Finally, a combined system consisting of ECC-induced droplet dispensing and electrophoresis of charged droplet (ECD)-driven manipulation systems is constructed. This integrated platform will provide increased utility and flexibility in microfluidic applications because a charged droplet can be delivered toward the intended position by programmable electric control.

  16. Vitamin D status among pulmonary TB patients and non-TB controls

    DEFF Research Database (Denmark)

    Friis, Henrik; Range, Nyagosya; Changalucha, John;

    2013-01-01

    Little is known about vitamin D status in low-income populations burdened with infectious diseases. Hence, there is a need for data on correlates of serum 25-hydroxy vitamin D (S-25(OH)D) and its validity during infections.......Little is known about vitamin D status in low-income populations burdened with infectious diseases. Hence, there is a need for data on correlates of serum 25-hydroxy vitamin D (S-25(OH)D) and its validity during infections....

  17. Randomized controlled trial of icodextrin versus glucose containing peritoneal dialysis fluid.

    Science.gov (United States)

    Lin, Aiwu; Qian, Jiaqi; Li, Xiaomei; Yu, Xueqing; Liu, Wenhu; Sun, Yang; Chen, Nan; Mei, Changlin

    2009-11-01

    While peritoneal dialysis with icodextrin is commonly used in patients with poor peritoneal membrane characteristics, the data on the usefulness of this solution in patients with lower transport characteristics are limited. The study was designed to compare icodextrin to glucose in Chinese prevalent peritoneal dialysis patients of different peritoneal transport characteristics (PET) categories. This was a randomized, double-blind, perspective control study. Stable prevalent continuous ambulatory peritoneal dialysis (CAPD) patients were randomized to either 7.5% icodextrin (ICO) or 2.5% glucose (GLU) solution for 4 wk. Peritoneal membrane function was measured to define PET category in baseline. Creatinine clearance (Ccr), urea nitrogen clearance (C(BUN)), ultrafiltration (UF) during the long night dwell, dialysate, and metabolic biomarkers were measured at baseline, 2, and 4 wk. UF, Ccr, and C(BUN) were compared among different PET categories. A total of 201 CAPD patients were enrolled in the study. There were no baseline differences between the groups. Following 2 and 4 wk of therapy, Ccr, C(BUN,) and UF were all significantly higher in the ICO versus the GLU group. Additionally, switching to ICO resulted in a significant increase in UF in high, high-average, and low-average transporters as compared with baseline. The extent of increased UF was more obvious in higher transporters. Blood cholesterol level in the ICO group decreased significantly than that in the GLU group. Compared with glucose-based solution, 7.5% icodextrin significantly improved UF and small solute clearance, even in patients with low-average peritoneal transport.

  18. Importância do exame do liquor de controle em meningite bacteriana como critério de alta Importance of cerebrospinal fluid control tests in bacterial meningitis cases as a discharge criterion

    Directory of Open Access Journals (Sweden)

    Diogo Buarque Cordeiro Cabral

    2008-04-01

    Full Text Available Há controvérsias sobre indicação do exame do liquor de controle em pacientes recuperados clinicamente de meningite bacteriana como critério de cura. Alguns autores defendem alta hospitalar após normalização clínica e liqüórica, outros que a análise do liquor não se justifica em todos os pacientes. Esta série de casos com comparação de grupos investiga alterações no exame liqüórico de controle e avalia a importância do exame na decisão da alta. De 297 pacientes estudados, em 89,9%, o liquor de controle não mudou a intenção de alta (liquor resolutivo, já em 10,1% a alta foi suspensa (liquor não-resolutivo. Destes, o esquema antibiótico foi trocado em 30%. Entre as variáveis que pudessem ser preditivas de liquor não-resolutivo, à admissão, proteinorraquia maior que 100mg/dL (p=0,04 e glicorraquia menor ou igual a 20mg/dL (p=0,03 associaram-se a chance 2,5 vezes maior, podendo ser úteis como critérios para indicar exame do liquor como controle de cura para alta.There is controversy regarding indications for cerebrospinal fluid control tests on patients who have clinically recovered from bacterial meningitis, as a cure criterion. Some authors advocate discharge after confirmation of clinical and cerebrospinal fluid normalization, while others maintain that cerebrospinal fluid analysis is not justified in all cases. This case series with group comparisons investigated changes seen in cerebrospinal fluid control tests and evaluated the importance of this for the discharge decision. Out of 297 patients studied, the cerebrospinal fluid control test did not change the discharge intention in 89.9% of the cases (healed cerebrospinal fluid, while in 10.1%, the discharge was suspended (non-healed cerebrospinal fluid. Of these, the antibiotic scheme was changed in 30%. Among the variables that might predict the presence of non-healed cerebrospinal fluid on admission, cerebrospinal fluid protein levels higher than 100mg/dl (p

  19. Investigation on Smoking Status and Tobacco Control Status of the Railway Workers%铁路职工吸烟状况及控烟能力调查

    Institute of Scientific and Technical Information of China (English)

    万雪; 陈继玮

    2015-01-01

    目的:调查了解长春市铁路职工吸烟状况及控烟能力,为深入开展铁路职工戒烟活动提供依据。方法采用系统整群抽样,调查了全市与站车工作关系紧密的2000名铁路职工,采用调查问卷的方法,对长春市铁路职工吸烟状况及控烟能力进行调查。结果调查的铁路职工中,男性吸烟率明显高于女性;高吸烟率主要集中在25~35岁和45~55岁两组中;小学及以下文化程度的吸烟率显著高于初高中以上文化程度及大专以上文化程度的职工;80.18%的人认为应当开展禁烟工作;大部分铁路职工对候车室及车厢内的空气不满意,表现出了对控烟的愿望。结论有必要在长春市铁路职工中开展吸烟危害、戒烟知识和戒烟方法的培训。积极开展创建无烟铁路活动,创建铁路无烟环境,有效控制长春市铁路职工吸烟成瘾的发生、发展。%Objective To understand the investigation on smoking status and tobacco control status of the railway workers in Changchun, and to provide science basis for investigation on smoking status. Methods The system cluster sampling method, investigated in the city railway station car works closely with 2000 employees, questionnaire method is used to Changchun Railway workers smoking status and smoking control ability in the investigation. Results The railway workers were sur-veyed, male smoking rate was significantly higher than females. High smoking rates are mainly concentrated in two groups 25~35 and 45~55 years of age. Educational level of primary schools and lower smoking rates are significantly higher than the beginning of high school or higher and tertiary education level above the staff. 80.18% believe work should be carried out smoking. The majority of railway workers not satisfied with waiting rooms and inside air, showed a desire for tobacco control. Conclusion It is necessary in Changchun Railway workers to carry out knowledge of

  20. Fluid Dynamical Control of Spacing and Symmetry Breaking in Orbital Wave Ripples

    Science.gov (United States)

    Nienhuis, J.; Perron, J.; Kao, J. C.; Myrow, P.

    2013-12-01

    Sand ripples in coastal environments and the rock record are a ubiquitous signature of the interaction of flows, bed topography and sediment transport. A common class of ripples, orbital wave ripples, exhibits a well-known linear relationship between the wavelength of the ripple pattern and the amplitude of wave-generated oscillatory flow. Based on this relationship, the ripple wavelength is often used as a paleoenvironmental indicator; and the height and spacing of modern ripples are major controls on bed roughness. However, the mechanism that selects the observed ratio of ripple wavelength to flow amplitude has not been explained. Orbital wave ripples are sustained by zones of reversed flow on the lee side of the crest that moves sand upslope toward the crest. Using a lattice Boltzmann numerical flow model to simulate two-dimensional flow over a rippled bed, we demonstrate a coupling of flow and ripples that leads to the observed equilibrium: if the ratio between the orbital diameter (double the flow amplitude) and ripple wavelength is 0.65 - the equilibrium ratio observed in laboratory experiments and in the field - the maximum length of the separation zone downstream of a ripple crest is exactly equal to the ripple wavelength. Longer separation zones, with vortices advected further, will erode the neighboring crest. Shorter separation zones will not be able to erode the adjacent troughs. In addition to this equilibrium morphology, orbital wave ripples display characteristic patterns as they evolve in response to changes in wave conditions. Multiple experiments have shown that large-scale symmetry is lost during adjustment to a new equilibrium. When the wave orbital diameter is shortened sufficiently, two new crests appear in every trough. Of these two, one decays, while the other keeps growing. Interestingly, the same side (right or left) is observed to 'win' in every trough. When the orbital diameter is lengthened, a 'bulging' instability occurs, in which

  1. Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome

    DEFF Research Database (Denmark)

    Jeppesen, P B; Gilroy, R; Pertkiewicz, M

    2011-01-01

    Teduglutide, a GLP-2 analogue, may restore intestinal structural and functional integrity by promoting repair and growth of the mucosa and reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS). This 24-week placebo-co......-controlled study evaluated the ability of teduglutide to reduce parenteral support in patients with SBS with intestinal failure....

  2. Inferior vena cava/aorta diameter index in the assessment of the body fluid status – a comparative study of measurements performed by experienced and inexperienced examiners in a group of young adults

    Science.gov (United States)

    Januszkiewicz, Emilia; Szmygel, Łukasz; Kosiak, Wojciech

    2014-01-01

    The assessment of the body fluid status is one the most challenging tasks in clinical practice. Although there are many methods to assess the body fluid status of patients, none of them is fully satisfactory in contemporary medical sciences. In the article below, we compare the results of measurements performed by experienced and inexperienced examiners based on the inferior vena cava/aorta diameter index in a sonographic hydration assessment. The study enrolled 50 young students at the age of 19–26 (the median age was 22.95) including 27 women and 23 men. The volunteers were examined in the supine position with GE Logiq 7 system and a convex transducer with the frequency of 2–5 MHz. The measurements were performed in the longitudinal and transverse planes by two inexperienced examiners – the authors of this paper, following a four-hour training conducted by an experienced sonographer. The longitudinal values of the inferior vena cava/aorta diameter index obtained in this study were similar to those found in the literature. The reference value for the inferior vena cava/aorta index determined by Kosiak et al., which constituted 1.2 ± 2 SD, for SD = 0.17, was similar to the values obtained by the authors of this paper which equaled 1.2286 ± 2 SD, for SD = 0.2. The article presented below proves that measuring the inferior vena cava/aorta diameter index is not a complex examination and it may be performed by physicians with no sonographic experience. Furthermore, the paper demonstrates that the inferior vena cava/aorta diameter index measured in the transverse plane is similar to the inferior vena cava/aorta diameter index determined in the longitudinal plane. Thus, both measurements may be used interchangeably to assess the hydration status of patients. PMID:26675322

  3. Inferior vena cava/aorta diameter index in the assessment of the body fluid status - a comparative study of measurements performed by experienced and inexperienced examiners in a group of young adults.

    Science.gov (United States)

    Durajska, Kaja; Januszkiewicz, Emilia; Szmygel, Łukasz; Kosiak, Wojciech

    2014-09-01

    The assessment of the body fluid status is one the most challenging tasks in clinical practice. Although there are many methods to assess the body fluid status of patients, none of them is fully satisfactory in contemporary medical sciences. In the article below, we compare the results of measurements performed by experienced and inexperienced examiners based on the inferior vena cava/aorta diameter index in a sonographic hydration assessment. The study enrolled 50 young students at the age of 19-26 (the median age was 22.95) including 27 women and 23 men. The volunteers were examined in the supine position with GE Logiq 7 system and a convex transducer with the frequency of 2-5 MHz. The measurements were performed in the longitudinal and transverse planes by two inexperienced examiners - the authors of this paper, following a four-hour training conducted by an experienced sonographer. The longitudinal values of the inferior vena cava/aorta diameter index obtained in this study were similar to those found in the literature. The reference value for the inferior vena cava/aorta index determined by Kosiak et al., which constituted 1.2 ± 2 SD, for SD = 0.17, was similar to the values obtained by the authors of this paper which equaled 1.2286 ± 2 SD, for SD = 0.2. The article presented below proves that measuring the inferior vena cava/aorta diameter index is not a complex examination and it may be performed by physicians with no sonographic experience. Furthermore, the paper demonstrates that the inferior vena cava/aorta diameter index measured in the transverse plane is similar to the inferior vena cava/aorta diameter index determined in the longitudinal plane. Thus, both measurements may be used interchangeably to assess the hydration status of patients.

  4. 基于FluidSIM-Hydraulic的注塑机液压回路控制分析%Control Analysis for Hydraulic Loop of Plastic Injection Molding Machine Based on FluidSIM-Hydraulic

    Institute of Scientific and Technical Information of China (English)

    叶金玲; 周钦河; 黄诚

    2015-01-01

    Hydraulic control system of plastic injection molding machine was designed using FluidSIM⁃Hydraulic software. The structure and working principle of the plastic injection molding machine were introduced, its hydraulic loop and electric loop were de⁃signed and optimized. The plastic injection molding machine has gained good affection in actual production.%基于FluidSIM⁃Hydraulic软件对注塑机液压回路控制系统进行分析。介绍了注塑机的结构原理,并优化设计了液压回路及电气控制系统,通过二者有效的结合成功地将模拟仿真后的模型应用到了实际生产中,取得了良好的效果。

  5. Electrically Controllable Microparticle Synthesis and Digital Microfluidic Manipulation by Electric-Field-Induced Droplet Dispensing into Immiscible Fluids

    Science.gov (United States)

    Um, Taewoong; Hong, Jiwoo; Kang, In Seok

    2016-11-01

    The dispensing of tiny droplets is a basic and crucial process in a myriad of applications, such as DNA/protein microarray, cell cultures, chemical synthesis of microparticles, and digital microfluidics. This work demonstrates the droplet dispensing into immiscible fluids through electric charge concentration (ECC) method. Three main modes (i.e., attaching, uniform and bursting modes) are exhibited as a function of flow rates, applied voltage and gap distance between the nozzle and the oil surface. Through a conventional nozzle with diameter of a few millimeters, charged droplets with volumes ranging from a few μL to a few tens of nL can be uniformly dispensed into the oil chamber without reduction in nozzle size. Based on the features of the proposed method (e.g., formation of droplets with controllable polarity and amount of electric charge in water and oil system), a simple and straightforward method is developed for microparticle synthesis, including preparation for colloidosomes and fabrication of Janus microparticles with anisotropic internal structures. Finally, a combined system consisting of ECC-induced droplet dispensing and electrophoresis of charged droplet (ECD)-driven manipulation systems is constructed. This work was supported by the BK21Plus Program for advanced education of creative chemical engineers of the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIP).

  6. Nanostructured hydroxyapatite/poly(lactic-co-glycolic acid) composite coating for controlling magnesium degradation in simulated body fluid

    Science.gov (United States)

    Johnson, Ian; Akari, Khalid; Liu, Huinan

    2013-09-01

    Biodegradable magnesium (Mg) and its alloys have many attractive properties (e.g. comparable mechanical properties to cortical bone) for orthopedic implant applications, but they degrade too rapidly in the human body to meet clinical requirements. Nanostructured hydroxyapatite (nHA)/poly(lactic-co-glycolic acid) (PLGA) composite coatings provide synergistic properties for controlling degradation of Mg-based substrates and improving bone-implant integration. In this study, nHA/PLGA composites were spin coated onto Mg-based substrates and the results showed that the nHA/PLGA coatings retained nano-scale features with nHA dispersed in PLGA matrix. In comparison with non-coated Mg, the nHA/PLGA composite coated Mg increased the corrosion potential and decreased the corrosion current in revised simulated body fluid (rSBF). After 24 h of immersion in rSBF, increased calcium phosphate (CaP) deposition and formation of Mg-substituted CaP rosettes were observed on the surface of the nHA/PLGA coated Mg, indicating greater bioactivity. In contrast, no significant CaP was deposited on the PLGA coated Mg. Since both PLGA coating and nHA/PLGA coating showed some degree of delamination from Mg-based substrates during extended immersion in rSBF, the coating processing and properties should be further optimized in order to take full advantage of biodegradable Mg and nHA/PLGA nanocomposites for orthopedic applications.

  7. Proteome profiles of vaginal fluids from women affected by bacterial vaginosis and healthy controls: outcomes of rifaximin treatment.

    Science.gov (United States)

    Cruciani, Federica; Wasinger, Valerie; Turroni, Silvia; Calanni, Fiorella; Donders, Gilbert; Brigidi, Patrizia; Vitali, Beatrice

    2013-11-01

    This study was designed to characterize the proteome of vaginal fluid (VF) from women with bacterial vaginosis (BV) in comparison with that from healthy women, and to evaluate the effect exerted by rifaximin vaginal tablets. Women with BV (n = 39) and matched healthy controls (n = 41) were included in the study. BV patients were distributed among four groups receiving different doses of rifaximin. Vaginal rinsings were collected at the screening visit from all the participants and at a follow-up visit from BV-affected women. The VF proteome was analysed by tandem mass spectrometry using an Orbitrap mass analyser. A large number of human proteins were differentially expressed in women with BV in comparison with healthy women (n = 118) and in BV-affected women treated with rifaximin (n = 284). In both comparisons, a high proportion of the dysregulated proteins (∼20%) were involved in the innate immune response. Twenty-one of 24 proteins increased in abundance in women with BV versus healthy women and 31/59 proteins decreased after rifaximin treatment, suggesting a general reduction of the immune response resulting from the therapy. Major changes in protein abundance were found following treatment with 25 mg of rifaximin once daily for 5 days. BV is associated with a massive change in the VF proteome, mainly regarding the abundance of proteins involved in the innate immune response. Rifaximin at a dosage of 25 mg for 5 days modulated the vaginal proteome, counteracting the alterations associated with the BV condition.

  8. Women's Employment Status, Coercive Control, and Intimate Partner Violence in Mexico

    Science.gov (United States)

    Villarreal, Andres

    2007-01-01

    Findings from previous studies examining the relation between women's employment and the risk of intimate partner violence have been mixed. Some studies find greater violence toward women who are employed, whereas others find the opposite relation or no relation at all. I propose a new framework in which a woman's employment status and her risk of…

  9. Vitamin D Status among Pulmonary TB Patients and Non-TB Controls

    DEFF Research Database (Denmark)

    Friis, Henrik; Range, Nyagosya; Changalucha, John

    2013-01-01

    Little is known about vitamin D status in low-income populations burdened with infectious diseases. Hence, there is a need for data on correlates of serum 25-hydroxy vitamin D (S-25(OH)D) and its validity during infections....

  10. Hydrothermal Fluid Permeability, Temperature, and Nutrient Fluxes: Three Controls on the Structure and the Dynamics of Subsurface Extremophilic Microbe Communities

    Science.gov (United States)

    Ryan, M. P.; Yang, J.

    2002-05-01

    We continue to develop a set of models whose aim is to provide broad constraints on the range of possible community structures for subsurface thermally-tolerant microbes. We combine studies of the three-dimensional internal structure of the dike and sill complexes of active volcanoes, studies of the scale- and direction-dependent 3-D in-situ permeability of intrusive and extrusive rocks from in-situ and laboratory data, numerical modelling of hydrothermal convection in volcanic interiors, data on the optimal metabolic and life-limiting thermal requirements of extremophilic microbes, with the set of nutrients and nutrient pathways required for the survival of given species of thermophiles and hyperthermophiles. With this mix of data bases and analysis tools, we can begin to divine a set of broad theoretical guidelines for constraining the structure and dynamics of extremophilic communities in the subsurface environments of volcanoes. We are searching for the first-order controls on transport. The effects of mineral attachment, detachment, and microbial reproduction may be incorporated in refinements of this basic model. Critical thermal intervals and/or isotherms that correlate with (1) optimal metabolic and (2) life-limiting temperatures for thermophilic microbes are, e.g., in degrees Celcius: Thermus thermophilius [70, 85]; Thermomicrobium roseum [70-75, 85]; Thermus aquaticus [70, 79]; and Sulfolobus acidocaldarius [70-75, 90]. Numerical models of the convective migration of thermophilic (50-80 C), and hyperthermophilic (80-113 C) microbes and their macromolecular amino acid building blocks (113- ~200 C) have been developed that explicitly incorporate the roles of fractures and fluid properties. Fluid transport properties are evaluated through the optimal metabolic and life-limiting temperate ranges and beyond. These models quantify our intuition with respect to controls on community structure and dynamics. Important relationships appear to be: (1) Great

  11. Study of lipid status in the euglycemic offsprings of diabetic parents with sex, age matched controls among South Indian population.

    Science.gov (United States)

    Carlton Johnny, J; Anuratha, N

    2016-01-01

    Metabolic syndrome has a silent but a fatal course. So, if we are able to identify the subjects in the early course of the disease then we will be able to prevent them from fatal complications later. To study the lipid status among euglycemic offspring of diabetic parents by appropriately matching for sex, and age in controls. It is a case control study involving 52 subjects and 25 controls done in a tertiary care center in Chennai. Using inclusion and exclusion criteria 52 euglycemic offspring as subjects and 25 controls were taken. Serum high density lipoprotein (HDL), serum triglycerides, blood pressure and waist circumference we obtained. The results were tabulated and studied. Student t test was employed. Siblings of diabetic parents had lower levels of serum HDL. Odds ratio showed that offspring's of diabetic parents had the odds of having low HDL 4.67 times when compared to the controls with a confidence interval of 1.6001-13.6563, P value of 0.0048. The other parameters did not show any gross variation. Siblings of diabetic fathers had a more deranged profile than the siblings of diabetic mothers. There is significant association between parental diabetic status and dyslipidemia. If they are detected early then progress to complications can be delayed. Copyright © 2016. Published by Elsevier Ltd.

  12. Study of the structural control of fluid flow within the Cerro Prieto Geothermal Field, Baja California, Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Noble, J.E.; Manon, M.A.; Lippmann, M.J.; Witherspoon, P.A.

    1977-10-01

    The Lawrence Berkeley Laboratory and the Comision Federal de Electricidad of Mexico are conducting a joint investigation of the Cerro Prieto Geothermal Field, located approximately 35 km south of Mexicali, Baja California, Mexico, in the Sea of Cortez-Salton Trough. Recent analyses of various geophysical/electrical logs, temperature logs, production and geochemical data and the subsequently developed preliminary model of the structure of the geothermal system and the distribution of geothermal fluids are presented. Techniques routinely applied to petroleum exploration were successfully used in the development of a preliminary model of this water-dominated system. The study indicates the upwelling of geothermal fluids along an east bounding fault from a deep, as yet unexplored source. The fluids dissipate into various sand horizons at various depths. The resulting stratigraphic and fluid flow model is of importance in planning additional developments of the Cerro Prieto Geothermal Field.

  13. The effect of insurance status and parental education on glycemic control and cardiovascular disease risk profile in youth with Type 1 Diabetes

    OpenAIRE

    Majidi, Shideh; Wadwa, R. Paul; Bishop, Franziska K.; Klingensmith, Georgeanna J; Rewers, Marian; McFann, Kim; Maahs, David M.

    2014-01-01

    Background Adult studies have shown a correlation between low socioeconomic status and Type 1 Diabetes complications, but studies have not been done in children to examine the effect of socioeconomic status on risk for future complications. This study investigates the relationship between insurance status and parental education and both glycemic control and cardiovascular disease (CVD) risk factors in youth with type 1 diabetes. Methods A cross-sectional study of 295 youth with established ty...

  14. Seasonal-dependent variations in metabolic status of spermatozoa and antioxidant enzyme activity in the reproductive tract fluids of wild boar/domestic pig hybrids.

    Science.gov (United States)

    Dziekońska, A; Fraser, L; Koziorowska-Gilun, M; Strzezek, J; Koziorowski, M; Kordan, W

    2014-01-01

    This study investigated seasonal changes in the metabolic performance of spermatozoa and activity of the antioxidant enzymes in the seminal plasma of three wild boar/domestic pigs (aged 1.5 to 2.5 years) and the activity of the antioxidant enzymes in fluids of the cauda epididymidis and vesicular glands from 16 wild boar/domestic pig hybrids (aged 1 to 3 years). Parameters of the sperm metabolic activity, such as total motility, mitochondrial functions, and measurements of oxygen uptake, ATP content and L-lactate production, were analyzed during the spring-summer and autumn-winter periods. Besides these sperm metabolic parameters, the sperm membrane integrity was also assessed. Total protein content and activity of the antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), were measured in the reproductive tract fluids. There were no marked significant differences (P > 0.05) between the seasonal periods in terms of sperm motility, mitochondrial function and oxygen uptake; however, spermatozoa collected during the autumn-winter period exhibited higher (P pig hybrids.

  15. Understanding controls on biotic assemblages and ecological status in Zambian rivers for the development of sustainable monitoring protocols

    Science.gov (United States)

    Kennedy, Michael; Gibbins, Chris; Lowe, Steven; Dallas, Helen; Taylor, Jonathan; Lang, Pauline; Saili, Kothelani; Sichingabula, Henry; Murphy, Kevin

    2014-05-01

    The water resources of Zambia are likely to experience increasing multiple pressures in the future as a result of very high predicted population growth, industrial development, land use change, and potentially, altered regional rainfall patterns. It is well known that rivers in tropical regions typically have a rich biodiversity, controlled in part by inter-annual variability in climate and discharge, and in part by local catchment conditions. However, till recently little country-wide work had had been carried out on the biota of Zambian rivers, and little was therefore known about the ecological status, or degree of catchment alteration of many of the rivers. To underpin sustainable water management, protocols have been developed to assess the ecological status of Zambian rivers. This paper describes the development of the protocols and their application to provide the first extensive assessment of the ecological status of rivers in the country. The protocols were designed to be simple, and hence rapid, easy and relatively inexpensive to apply. Status scores were derived for individual sites using sensitivity weightings from 3 major groups (macrophytes, diatoms and macroinvertebrates). The general approach was based on schemes used successfully elsewhere, with species and family sensitivity weightings modified so as be appropriate to Zambia. Modifications were based on a survey of 140 Zambian rivers, incorporating data on species distributions, physical habitat conditions and water quality. Analysis of historical data suggests that established Freshwater Ecoregions reflect hydro-climatic variability across Zambia. Survey data indicate that most of the spatial variation in biological assemblages across the country reflects these same hydro-climatic gradients, in addition to hydrochemical differences linked to geology. Site status scores suggest that rivers are generally in good health, although exceptions occur in some large urban areas and a small number of

  16. Status, Vision, and Challenges of an Intelligent Distributed Engine Control Architecture (Postprint)

    Science.gov (United States)

    2007-09-18

    same regardless of application; a DCS ( networked control system ) is significantly more powerful, flexible, and scaleable than a non- networked ... control system (centralized control), and businesses can save and make more money building distributed control over the long term than they can with

  17. Patient-Physician Communication About Code Status Preferences: A Randomized Controlled Trial

    Science.gov (United States)

    Rhondali, Wadih; Perez-Cruz, Pedro; Hui, David; Chisholm, Gary B.; Dalal, Shalini; Baile, Walter; Chittenden, Eva; Bruera, Eduardo

    2013-01-01

    Purpose Code status discussions are important in cancer care. The best modality for such discussions has not been established. Our objective was to determine the impact of a physician ending a code status discussion with a question (autonomy approach) versus a recommendation (beneficence approach) on patients' do-not-resuscitate (DNR) preference. Methods Patients in a supportive care clinic watched two videos showing a physician-patient discussion regarding code status. Both videos were identical except for the ending: one ended with the physician asking for the patient's code status preference and the other with the physician recommending DNR. Patients were randomly assigned to watch the videos in different sequences. The main outcome was the proportion of patients choosing DNR for the video patient. Results 78 patients completed the study. 74% chose DNR after the question video, 73% after the recommendation video. Median physician compassion score was very high and not different for both videos. 30/30 patients who had chosen DNR for themselves and 30/48 patients who had not chosen DNR for themselves chose DNR for the video patient (100% v/s 62%). Age (OR=1.1/year) and white ethnicity (OR=9.43) predicted DNR choice for the video patient. Conclusion Ending DNR discussions with a question or a recommendation did not impact DNR choice or perception of physician compassion. Therefore, both approaches are clinically appropriate. All patients who chose DNR for themselves and most patients who did not choose DNR for themselves chose DNR for the video patient. Age and race predicted DNR choice. PMID:23564395

  18. Archetypal and rearranged sequences of human polyomavirus JC transcription control region in peripheral blood leukocytes and in cerebrospinal fluid.

    Science.gov (United States)

    Ciappi, S; Azzi, A; De Santis, R; Leoncini, F; Sterrantino, G; Mazzotta, F; Mecocci, L

    1999-04-01

    Two forms of human polyomavirus JC (JCV) genome are known based upon the structure of the transcriptional control region (TCR) of the virus: the archetypal form, which is commonly detected in urine, and the rearranged form, which was first detected in brain tissue from progressive multifocal leukoencephalopathy (PML) patients. The latter actually includes a group of TCR variants that, relative to the former, are characterized by various deletions and/or duplications. The aim of this study was to establish whether or not a correlation exists among the TCR type, the spreading of the virus within the host and its ability to cause PML. JCV TCR sequences from peripheral blood leukocytes (PBL) and cerebrospinal fluid (CSF) obtained from various groups of patients were compared. JCV with archetypal TCR was detected in CSF and PBL specimens from patients without neurological disorders or who eventually received a diagnosis of a non-PML neurological disorder. Rearranged TCR sequences were detected in all the CSF and PBL specimens from PML patients. The high similarity observed between the TCR structure detected in PBL and CSF specimens from individual patients could strengthen the hypothesis that PBL has a role in spreading JCV to the brain. Moreover, heterogeneous TCR patterns have been shown in individual PBL specimens from PML patients. This supports the hypothesis that, in PBL, JCV may replicate and undergo rearrangements of the TCR. The detection of JCV DNA by PCR in CSF independently from PML, although rare, could suggest that this assay is not sufficient for a virological diagnosis of PML. Further studies are required to assess the usefulness of quantitative assays or TCR typing in combination with PCR for diagnostic purposes.

  19. Fluid Mechanics.

    Science.gov (United States)

    Drazin, Philip

    1987-01-01

    Outlines the contents of Volume II of "Principia" by Sir Isaac Newton. Reviews the contributions of subsequent scientists to the physics of fluid dynamics. Discusses the treatment of fluid mechanics in physics curricula. Highlights a few of the problems of modern research in fluid dynamics. Shows that problems still remain. (CW)

  20. Fluid Interfaces

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius

    2001-01-01

    Fluid interaction, interaction by the user with the system that causes few breakdowns, is essential to many user interfaces. We present two concrete software systems that try to support fluid interaction for different work practices. Furthermore, we present specificity, generality, and minimality...... as design goals for fluid interfaces....

  1. Fluid Mechanics.

    Science.gov (United States)

    Drazin, Philip

    1987-01-01

    Outlines the contents of Volume II of "Principia" by Sir Isaac Newton. Reviews the contributions of subsequent scientists to the physics of fluid dynamics. Discusses the treatment of fluid mechanics in physics curricula. Highlights a few of the problems of modern research in fluid dynamics. Shows that problems still remain. (CW)

  2. Drilling Fluid Technique Status and Games in Tahe Oilfield%塔河油田钻井液技术现状及对策

    Institute of Scientific and Technical Information of China (English)

    魏新勇; 刘庆来

    2001-01-01

    Field applications of drilling fluids in Tahe oilfield are introduced in detail.The basic problems during re-drilling operations are summarized,such as serious stuck pipes and hole enlargement in re-drilling intervals.The primary technical problems and measures are also put forward in this paper.%详细介绍了塔河油田现场钻井液应用情况,分析归纳出了二开及三开井段钻井液存在的主要问题,即二开井段的严重阻卡及三开井段的井径扩大,并系统地提出了应注意的主要技术问题和解决方案。

  3. Gamma oscillatory power is impaired during cognitive control independent of medication status in first-episode schizophrenia.

    Science.gov (United States)

    Minzenberg, Michael J; Firl, Alana J; Yoon, Jong H; Gomes, Glenn C; Reinking, Celeste; Carter, Cameron S

    2010-12-01

    Schizophrenia is characterized by impaired cognitive control associated with prefrontal cortex dysfunction, but the underlying pathophysiological mechanisms remain unknown. Higher cognitive processes are associated with cortical oscillations in the gamma range, which are also impaired in chronic schizophrenia. We tested whether cognitive control-related gamma deficits are observed in first-episode patients, and whether they are associated with antipsychotic medication exposure. Fifty-three first-episode schizophrenia patients (21 without antipsychotic medication treatment) and 29 healthy control subjects underwent electroencephalography (EEG) during performance of a preparatory cognitive control task (preparing to overcome prepotency or POP task). The first-episode schizophrenia patient group was impaired (relative to the control group) on task performance and on delay-period gamma power at each of the three subgroups of frontal electrodes. The unmedicated patient subgroup was similarly impaired compared with controls, and was not different on these measures compared with the medicated patient subgroup. In contrast, delay-period theta power was not impaired in the full patient group nor in the unmedicated patient subgroup. Impaired cognitive control-related gamma cortical oscillatory activity is present at the first psychotic episode in schizophrenia, and is independent of medication status. This suggests that altered local circuit function supporting high-frequency oscillatory activity in prefrontal cortex ensembles may serve as the pathophysiological substrate of cognitive control deficits in schizophrenia.

  4. Maternal vitamin D status in type 1 diabetic pregnancy: impact on neonatal vitamin D status and association with maternal glycaemic control.

    Directory of Open Access Journals (Sweden)

    Sarah E Bennett

    Full Text Available OBJECTIVE: The first aim of this study was to assess 25-hydroxy vitamin D (25OHD concentrations in women with type 1 diabetes (T1DM during pregnancy, post-delivery and also foetal (cord blood 25OHD concentrations and to examine relationships between these. The second aim of the study was to investigate potential interactions between maternal body mass index (BMI and foetal vitamin D status. A further study aim was to examine potential relationships between maternal 25OHD and glycosylated haemoglobin (HbA1c throughout pregnancy. RESEARCH DESIGN AND METHODS: This was an observational study of 52 pregnant controls without diabetes and 65 pregnant women with T1DM in a university teaching hospital. Maternal serum 25OHD was measured serially throughout the pregnancy and post-delivery. Cord blood 25OHD was measured at delivery. 25OHD was measured by liquid chromatography tandem mass spectrometry (LC-MS/MS. RESULTS: Vitamin D deficiency (25OHD 30 kg/m(2 (nmol/L ± SD; 19.93 ± 11.15 vs. 13.73 ± 4.74, p=0.026]. In the T1DM group, HbA1c at booking was significantly negatively correlated with maternal 25OHD at all 3 trimesters (p=0.004; p=0.001; p=0.05. CONCLUSION: In T1DM pregnancy, low vitamin D levels persist throughout gestation and post-delivery. Cord blood vitamin D levels correlate with those of the mother, and are significantly lower in obese women than in their normal weight counterparts. Maternal vitamin D levels exhibit a significant negative relationship with HbA1c levels, supporting a potential role for this vitamin in maintaining glycaemic control.

  5. Status of infection control policies and organisation in European hospitals, 2001: the ARPAC study.

    NARCIS (Netherlands)

    Struelens, M.J.; Wagner, D.; Bruce, J.; MacKenzie, F.M.; Cookson, B.; Voss, A.; Broek, P.J.J.A. van den; Gould, I.

    2006-01-01

    Patient safety in hospital care depends on effective infection control (IC) programmes. The Antimicrobial Resistance Prevention and Control (ARPAC) study assessed the organisation, components and human resources of IC programmes in European hospitals. A questionnaire survey of policies and procedure

  6. [The present status and development of thermal control system of spacesuits for extravehicular activity].

    Science.gov (United States)

    Zhao, C Y; Sun, J B; Yuan, X G

    1999-04-01

    With the extension of extravehicular activity (EVA) duration, the need for more effective thermal control of EVA spacesuits is required. The specific schemes investigated in heat sink system for EVA are discussed, including radiator, ice storage, metal hydride heat pump, phase-change storage/radiator and sublimator. The importance and requirements of automatic thermal control for EVA are also discussed. Existed automatic thermal control for EVA are reviewed. Prospects of further developments of thermal control of spacesuits for EVA are proposed.

  7. Nutritional status, glycemic control and its associated risk factors among a sample of type 2 diabetic individuals, a pilot study

    Directory of Open Access Journals (Sweden)

    Somayyeh Firouzi

    2015-01-01

    Full Text Available Background: The prevalence of type 2 diabetes is increasing in Malaysia, with most patients poorly controlled. Hence, this study aimed to determine nutritional and metabolic status as well as blood pressure of Malaysian patients with type 2 diabetes mellitus and identify associated risk factors for poor glycemic control. Materials and Methods: A total of 104 type 2 diabetic patients were recruited and completed a questionnaire covering socio-demographic status, 3-day diet records, and physical activity. Anthropometry and glycemic control parameters, lipid profile and blood pressure were also measured. Results: Subjects were on average 56.7±9.9 years old with a mean duration of diabetes of 6.5 ± 5.0 years. The mean hemoglobin A1c of the subjects was 7.6% ± 1.4%, with only 20.2% achieving the target goal of <6.5% with no significant differences between genders. The mean body mass index was 26.9 ± 4.7 kg/m 2 , with 86.5% either were overweight or obese. Only 10.6% of the subjects exercised daily. The proportions of macronutrients relative to total energy intake were consistent with the recommendations of most diabetes associations. The adjusted odds of having poor glycemic control were 3.235 (1.043-10.397 (P < 0.05 higher among those who had high density lipoprotein cholesterol levels below the normal range. Those taking one or two types of oral anti-diabetic drugs had 19.9 (2.959-87.391 (P < 0.01 and 14.3 (2.647-77.500 (P < 0.01 higher odds of poor glycemic control respectively compared to those who were being treated by diet alone. Conclusion: Poor glycemic control was prevalent among Malaysian diabetic patients, and this could be associated with low levels of HDL and being treated with oral anti-diabetes agents.

  8. Status of a digital integrated propulsion/flight control system for the YF-12 airplane

    Science.gov (United States)

    Reukauf, P. J.; Burcham, F. W., Jr.; Holzman, J. K.

    1975-01-01

    The NASA Flight Research Center is engaged in a program with the YF-12 airplane to study the control of interactions between the airplane and the propulsion system. The existing analog air data computer, autothrottle, autopilot, and inlet control system are to be converted to digital systems by using a general purpose airborne computer and interface unit. First, the existing control laws will be programmed in the digital computer and flight tested. Then new control laws are to be derived from a dynamic propulsion model and a total force and moment aerodynamic model to integrate the systems. These control laws are to be verified in a real time simulation and flight tested.

  9. Integrating remote sensing, field studies and CO2 surveys to unravel structural controls on fluid pathways at a young rift volcano

    Science.gov (United States)

    Hutchison, W.; Mather, T. A.; Pyle, D. M.; Biggs, J.; Yirgu, G.

    2014-12-01

    In volcanically and seismically active rift systems, pre-existing faults can play a significant role in the development of a volcanic complex, ultimately providing high permeability pathways that magma, hydrothermal fluids and gas can ascend to the surface. The Main Ethiopian Rift (MER) provides an ideal natural laboratory to investigate how pre-existing structures influence active volcanic processes because it hosts a number of young volcanic complexes within an active extensional tectonic setting. In this presentation we bring together observations from new high spatial resolution airborne imagery, field campaigns and CO2 degassing surveys to examine how magma, hydrothermal fluid and gas pathways are coupled to the major structural features on Aluto, a typical young silicic volcanic complex of the MER. Digital mapping of the volcanic complex using new LiDAR DEMs (2-m pixel) reveal that a significant number of lava flow vents and explosion craters on Aluto may be linked to a structural control by either rift-aligned faults that dissect the complex or a volcanic ring fracture. Mapping of surface hydrothermal alteration with aerial photos (geothermal fluid upwellings and confirms their links to the main structures. Results of volcanic CO2 degassing surveys also confirm elevated fluxes (>>100 g m-2 d-1) along major faulting and volcanic structures. There are, however, significant variations in CO2 flux along the fault zones, which can be linked to differences in near surface permeability caused by changes in topography and surface lithology. Overall these different observations of how lava, hydrothermal fluids and gas reach the surface are complementary and provide a strong case for the overarching structural controls on volcanic fluid pathways at present and throughout the evolution of the complex.

  10. Description, validation, and modification of the Guyton model for space-flight applications. Part A. Guyton model of circulatory, fluid and electrolyte control. Part B. Modification of the Guyton model for circulatory, fluid and electrolyte control

    Science.gov (United States)

    Leonard, J. I.

    1985-01-01

    The mathematical model that has been a cornerstone for the systems analysis of space-flight physiological studies is the Guyton model describing circulatory, fluid and electrolyte regulation. The model and the modifications that are made to permit simulation and analysis of the stress of weightlessness are described.

  11. Association of Arsenic Methylation Capacity with Developmental Delays and Health Status in Children: A Prospective Case-Control Trial

    Science.gov (United States)

    Hsueh, Yu-Mei; Chen, Wei-Jen; Lee, Chih-Ying; Chien, Ssu-Ning; Shiue, Horng-Sheng; Huang, Shiau-Rung; Lin, Ming-I.; Mu, Shu-Chi; Hsieh, Ru-Lan

    2016-11-01

    This case-control study identified the association between the arsenic methylation capacity and developmental delays and explored the association of this capacity with the health status of children. We recruited 120 children with developmental delays and 120 age- and sex-matched children without developmental delays. The health status of the children was assessed using the Pediatric Quality of Life Inventory (PedsQL) and Pediatric Outcomes Data Collection Instrument (PODCI). The arsenic methylation capacity was determined by the percentages of inorganic arsenic (InAs%), monomethylarsonic acid (MMAV%), and dimethylarsinic acid (DMAV%) through liquid chromatography and hydride generation atomic absorption spectrometry. Developmental delays were significantly positively associated with the total urinary arsenic concentration, InAs%, and MMAV%, and was significantly negatively associated with DMAV% in a dose-dependent manner. MMAV% was negatively associated with the health-related quality of life (HRQOL; -1.19 to -1.46, P children and in those with developmental delays. The arsenic methylation capacity is dose-dependently associated with developmental delays and with the health status of children, particularly those with developmental delays.

  12. Status and Development Trend of Ultra-High Temperature and High Density Drilling Fluid at Home and Abroad%国内外超高温高密度钻井液技术现状与发展趋势

    Institute of Scientific and Technical Information of China (English)

    王中华

    2011-01-01

    drilling fluids with high efficiency and low cost. This paper describes the status and development trend of oil based, synthetic and water based high-density drilling fluids being used in super-high temperature wells at home and abroad.

  13. Status of serum magnesium in Egyptian children with type 1 diabetes and its correlation to glycemic control and lipid profile.

    Science.gov (United States)

    Shahbah, Doaa; El Naga, Amr Abo; Hassan, Tamer; Zakaria, Marwa; Beshir, Mohamed; Al Morshedy, Salah; Abdalhady, Mohamed; Kamel, Ezzat; Rahman, Doaa Abdel; Kamel, Lamiaa; Abdelkader, May

    2016-11-01

    Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency, having 25% to 39% prevalence. This deficit could be associated with the development of late diabetic complications, especially macroangiopathy.We aimed to evaluate the status of serum Mg in children with type 1 diabetes and assess its relation to glycemic control and lipid profile.We included 71 Egyptian children with type 1diabetes having their follow-up at Pediatric Endocrinology outpatient clinic, Zagazig University Hospital and 71 age- and sex-matched control. We measured Serum magnesium, HbA1c, and lipid profile in all study subjects.Diabetic children had significantly lower serum magnesium level compared to control children (1.83 ± .27 mg/dL in diabetic children versus 2.00 ± .16 mg/dL in control children). Taking cut-off level of serum magnesium lipid profile. Hypomagnesemia was more evident in patients with poor diabetic control and those with higher atherogenic lipid parameters. We suggest that low serum magnesium may be included in pathogenesis of poor glycemic control and abnormal lipid profile in children with type 1 diabetes. We need to perform further studies on giving magnesium supplements in diabetic children with hypomagnesemia to observe the effect of correction of serum magnesium on glycemic control, lipid profile, and the risk of diabetic complications.

  14. Knowledge, Attitude, Practice, and Status of Infection Control among Iranian Dentists and Dental Students: A Systematic Review

    Science.gov (United States)

    Moradi Khanghahi, Behnam; Jamali, Zahra; Pournaghi Azar, Fatemeh; Naghavi Behzad, Mohammad; Azami-Aghdash, Saber

    2013-01-01

    Background and aims Infection control is an important issue in dentistry, and the dentists are primarily responsible for observing the relevant procedures. Therefore, the present study evaluated knowledge, attitude, practice, and status of infection control among Iranian dentists through systematic review of published results. Materials and methods In this systematic review, the required data was collected searching for keywords including infection, infection control, behavior, performance, practice, attitude, knowledge, dent*, prevention, Iran* and their Persian equivalents in PubMed, Science Direct, Iranmedex, SID, Medlib, and Magiran databases with a time limit of 1985 to 2012. Out of 698 articles, 15 completely related articles were finally considered and the rest were excluded due to lake of relev-ance to the study goals. The required data were extracted and summarized in an Extraction Table and were analyzed ma-nually. Results Evaluating the results of studies indicated inappropriate knowledge, attitude, and practice regarding infection control among Iranian dentists and dental students. Using personal protection devices and observing measures required for infection control were not in accordance with global standards. Conclusion The knowledge, attitudes, and practice of infection control in Iranian dental settings were found to be inadequate. Therefore, dentists should be educated more on the subject and special programs should be in place to monitor the dental settings for observing infection control standards. PMID:23875081

  15. Oral Fluid with Three Modes of Collection and Plasma Methamphetamine and Amphetamine Enantiomer Concentrations After Controlled Intranasal l-Methamphetamine Administration

    OpenAIRE

    Newmeyer, Matthew N.; Concheiro, Marta; da Costa, Jose Luiz; Flegel, Ronald; Gorelick, David A.; Huestis, Marilyn A.

    2015-01-01

    Methamphetamine is included in drug testing programs due to its high abuse potential. d-Methamphetamine is a scheduled potent central nervous system stimulant, while l-methamphetamine is the unscheduled active ingredient in the over-the-counter nasal decongestant Vicks® VapoInhaler™. No data are available in oral fluid (OF) and few in plasma after controlled Vicks VapoInhaler administration. We quantified methamphetamine and amphetamine enantiomers in OF collected with two different devices a...

  16. Weight Self-Regulation Process in Adolescence: The Relationship between Control Weight Attitudes, Behaviors, and Body Weight Status

    OpenAIRE

    Jordi ePich; Maria del Mar eBibiloni; Antoni ePons; Tur, Josep A

    2015-01-01

    Adolescents’ self-control weight behaviors were assessed (N = 1961; 12–17 years old; 2007–2008) in the Balearic Islands, Spain. The study analyzed the relationships between body weight status, body image, and self-weight concern, and actual attempts to lose weight by restrained eating and/or increased exercising. In terms of regulatory focus theory (RFT), we considered that efforts to lose or to maintain weight (successful or failed) would be motivated either by a “promotion focus” (to show a...

  17. Resistance exercise improves muscle strength, health status and pain intensity in fibromyalgia--a randomized controlled trial.

    Science.gov (United States)

    Larsson, Anette; Palstam, Annie; Löfgren, Monika; Ernberg, Malin; Bjersing, Jan; Bileviciute-Ljungar, Indre; Gerdle, Björn; Kosek, Eva; Mannerkorpi, Kaisa

    2015-06-18

    Fibromyalgia (FM) is characterized by persistent widespread pain, increased pain sensitivity and tenderness. Muscle strength in women with FM is reduced compared to healthy women. The aim of this study was to examine the effects of a progressive resistance exercise program on muscle strength, health status, and current pain intensity in women with FM. A total of 130 women with FM (age 22-64 years, symptom duration 0-35 years) were included in this assessor-blinded randomized controlled multi-center trial examining the effects of progressive resistance group exercise compared with an active control group. A person-centred model of exercise was used to support the participants' self-confidence for management of exercise because of known risks of activity-induced pain in FM. The intervention was performed twice a week for 15 weeks and was supervised by experienced physiotherapists. Primary outcome measure was isometric knee-extension force (Steve Strong®), secondary outcome measures were health status (FIQ total score), current pain intensity (VAS), 6MWT, isometric elbow-flexion force, hand-grip force, health related quality of life, pain disability, pain acceptance, fear avoidance beliefs, and patient global impression of change (PGIC). Outcomes were assessed at baseline and immediately after the intervention. Long-term follow up comprised the self-reported questionnaires only and was conducted after 13-18 months. Between-group and within-group differences were calculated using non-parametric statistics. Significant improvements were found for isometric knee-extension force (p = 0.010), health status (p = 0.038), current pain intensity (p = 0.033), 6MWT (p = 0.003), isometric elbow flexion force (p = 0.02), pain disability (p = 0.005), and pain acceptance (p = 0.043) in the resistance exercise group (n = 56) when compared to the control group (n = 49). PGIC differed significantly (p = 0.001) in favor of the resistance exercise group at post-treatment examinations

  18. Conditions of Mytilus edulis extracellular body fluids and shell composition in a pH-treatment experiment: Acid-base status, trace elements and δ11B

    Science.gov (United States)

    Heinemann, Agnes; Fietzke, Jan; Melzner, Frank; BöHm, Florian; Thomsen, JöRn; Garbe-SchöNberg, Dieter; Eisenhauer, Anton

    2012-01-01

    Mytilus edulis were cultured for 3 months under six different seawater pCO2 levels ranging from 380 to 4000 μatm. Specimen were taken from Kiel Fjord (Western Baltic Sea, Germany) which is a habitat with high and variable seawater pCO2 and related shifts in carbonate system speciation (e.g., low pH and low CaCO3 saturation state). Hemolymph (HL) and extrapallial fluid (EPF) samples were analyzed for pH and total dissolved inorganic carbon (CT) to calculate pCO2 and [HCO3-]. A second experiment was conducted for 2 months with three different pCO2 levels (380, 1400 and 4000 μatm). Boron isotopes (δ11B) were investigated by LA-MC-ICP-MS (Laser Ablation-Multicollector-Inductively Coupled Plasma-Mass Spectrometry) in shell portions precipitated during experimental treatment time. Additionally, elemental ratios (B/Ca, Mg/Ca and Sr/Ca) in the EPF of specimen from the second experiment were measured via ICP-OES (Inductively Coupled Plasma-Optical Emission Spectrometry). Extracellular pH was not significantly different in HL and EPF but systematically lower than ambient water pH. This is due to high extracellular pCO2 values, a prerequisite for metabolic CO2 excretion. No accumulation of extracellular [HCO3-] was measured. Elemental ratios (B/Ca, Mg/Ca and Sr/Ca) in the EPF increased slightly with pH which is in accordance with increasing growth and calcification rates at higher seawater pH values. Boron isotope ratios were highly variable between different individuals but also within single shells. This corresponds to a high individual variability in fluid B/Ca ratios and may be due to high boron concentrations in the organic parts of the shell. The mean δ11B value shows no trend with pH but appears to represent internal pH (EPF) rather than ambient water pH.

  19. Effects of vitamin A supplementation on iron status indices and iron deficiency anaemia: a randomized controlled trial.

    Science.gov (United States)

    Al-Mekhlafi, Hesham M; Al-Zabedi, Ebtesam M; Al-Maktari, Mohamed T; Atroosh, Wahib M; Al-Delaimy, Ahmed K; Moktar, Norhayati; Sallam, Atiya A; Abdullah, Wan Ariffin; Jani, Rohana; Surin, Johari

    2013-12-31

    Iron deficiency anaemia (IDA) is the most common nutritional deficiency in the world including developed and developing countries. Despite intensive efforts to improve the quality of life of rural and aboriginal communities in Malaysia, anaemia and IDA are still major public health problems in these communities particularly among children. A randomized, double-blind, placebo-controlled trial was conducted on 250 Orang Asli (aboriginal) schoolchildren in Malaysia to investigate the effects of a single high-dose of vitamin A supplementation (200,000 IU) on iron status indices, anaemia and IDA status. The effect of the supplement was assessed after 3 months of receiving the supplements; after a complete 3-day deworming course of 400 mg/day of albendazole tablets. The prevalence of anaemia was found to be high: 48.5% (95% CI=42.3, 54.8). Moreover, 34% (95% CI=28.3, 40.2) of the children had IDA, which accounted for 70.1% of the anaemic cases. The findings showed that the reduction in serum ferritin level and the increments in haemoglobin, serum iron and transferrin saturation were found to be significant among children allocated to the vitamin A group compared to those allocated to the placebo group (psupplementation showed a significant impact on iron status indices and IDA among Orang Asli children. Hence, providing vitamin A supplementation and imparting the knowledge related to nutritious food should be considered in the efforts to improve the nutritional and health status of these children as a part of efforts to improve the quality of life in rural and aboriginal communities.

  20. Effects of Vitamin A Supplementation on Iron Status Indices and Iron Deficiency Anaemia: A Randomized Controlled Trial

    Science.gov (United States)

    Al-Mekhlafi, Hesham M.; Al-Zabedi, Ebtesam M.; Al-Maktari, Mohamed T.; Atroosh, Wahib M.; Al-Delaimy, Ahmed K.; Moktar, Norhayati; Sallam, Atiya A.; Abdullah, Wan Ariffin; Jani, Rohana; Surin, Johari

    2013-01-01

    Iron deficiency anaemia (IDA) is the most common nutritional deficiency in the world including developed and developing countries. Despite intensive efforts to improve the quality of life of rural and aboriginal communities in Malaysia, anaemia and IDA are still major public health problems in these communities particularly among children. A randomized, double-blind, placebo-controlled trial was conducted on 250 Orang Asli (aboriginal) schoolchildren in Malaysia to investigate the effects of a single high-dose of vitamin A supplementation (200,000 IU) on iron status indices, anaemia and IDA status. The effect of the supplement was assessed after 3 months of receiving the supplements; after a complete 3-day deworming course of 400 mg/day of albendazole tablets. The prevalence of anaemia was found to be high: 48.5% (95% CI = 42.3, 54.8). Moreover, 34% (95% CI = 28.3, 40.2) of the children had IDA, which accounted for 70.1% of the anaemic cases. The findings showed that the reduction in serum ferritin level and the increments in haemoglobin, serum iron and transferrin saturation were found to be significant among children allocated to the vitamin A group compared to those allocated to the placebo group (p < 0.01). Moreover, a significant reduction in the prevalence of IDA by almost 22% than prevalence at baseline was reported among children in the vitamin A group compared with only 2.3% reduction among children in the placebo group. In conclusion, vitamin A supplementation showed a significant impact on iron status indices and IDA among Orang Asli children. Hence, providing vitamin A supplementation and imparting the knowledge related to nutritious food should be considered in the efforts to improve the nutritional and health status of these children as a part of efforts to improve the quality of life in rural and aboriginal communities. PMID:24384995