WorldWideScience

Sample records for fluid phase dmpc

  1. Alternative methods of determining phase transition temperatures of phospholipids that constitute liposomes on the example of DPPC and DMPC

    Energy Technology Data Exchange (ETDEWEB)

    Pentak, Danuta, E-mail: danuta.pentak@us.edu.pl

    2014-05-01

    Highlights: • New phase transition for DMPC was found. • FT-IR method is an important addition to the DSC studies. • The proposed method for determining the T{sub C} give very consistent results. - Abstract: In this work, alternatives to differential scanning calorimetry (DSC) as a method of determining the main phospholipid phase transition temperature are presented. The bilayer phase transitions from the ripple gel phase (P{sub β{sup ′}}) to the liquid-crystal phase (L{sub α}) of 1,2-dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC) and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) were studied by differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR) methods. In this work, two correlations between the DSC and FT-IR methods, and NMR and EPR methods are shown. The proposed methods allow for determining the T{sub C} temperature with a high degree of accuracy. Furthermore, a comparison of results obtained using the DSC and FT-IR methods allowed for an observation of a new DMPC phase transition. The liposomes analyzed in this work were obtained by the modified reverse-phase evaporation method (mREV)

  2. Effects of Fatty Acid Inclusion in a DMPC Bilayer Membrane

    DEFF Research Database (Denmark)

    Peters, Günther H.J.; Hansen, Flemming Yssing; Møller, Martin S.

    2009-01-01

    Free fatty acids in biomembranes have been proposed to be a central component in several cellular control and regulatory mechanisms. To elucidate some fundamental elements underlying this, we have applied molecular dynamics simulations and experimental density measurements to study the molecular...... packing and structure of oleic acid (HOA) and stearic acid (HSA) in fluid bilayers of dimyristoylphosphatidylcholine (DMPC). The experimental data show a small but consistent positive excess volume for fatty acid concentrations below 10 mol %. At higher concentrations the fatty acids mix ideally...... with fluid DMPC. The simulations, which were benchmarked against the densitometric data, revealed interesting differences in the structure and location of the fatty acids depending on their protonation status. Thus, the protonated (uncharged) acid is located rather deeply in the membrane with an average...

  3. Two-phase cooling fluids; Les fluides frigoporteurs diphasiques

    Energy Technology Data Exchange (ETDEWEB)

    Lallemand, A. [Institut National des Sciences Appliquees (INSA), 69 - Lyon (France)

    1997-12-31

    In the framework of the diminution of heat transfer fluid consumption, the concept of indirect refrigerating circuits, using cooling intermediate fluids, is reviewed and the fluids that are currently used in these systems are described. Two-phase cooling fluids advantages over single-phase fluids are presented with their thermophysical characteristics: solid fraction, two-phase mixture enthalpy, thermal and rheological properties, determination of heat and mass transfer characteristics, and cold storage through ice slurry

  4. Structure and Conformational Dynamics of DMPC/Dicationic Surfactant and DMPC/Dicationic Surfactant/DNA Systems

    Directory of Open Access Journals (Sweden)

    Maciej Kozak

    2013-04-01

    Full Text Available Amphiphilic dicationic surfactants, known as gemini surfactants, are currently studied for gene delivery purposes. The gemini surfactant molecule is composed of two hydrophilic “head” groups attached to hydrophobic chains and connected via molecular linker between them. The influence of different concentrations of 1,5-bis (1-imidazolilo-3-decyloxymethyl pentane chloride (gemini surfactant on the thermotropic phase behaviour of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC bilayers with and without the presence of DNA was investigated using Fourier transformed infrared (FTIR and circular dichroism (CD spectroscopies, small angle scattering of synchrotron radiation and differential scanning calorimetry. With increasing concentration of surfactant in DMPC/DNA systems, a disappearance of pretransition and a decrease in the main phase transition enthalpy and temperature were observed. The increasing intensity of diffraction peaks as a function of surfactant concentration also clearly shows the ability of the surfactant to promote the organisation of lipid bilayers in the multilayer lamellar phase.

  5. Phase transitions of quadrupolar fluids

    International Nuclear Information System (INIS)

    OShea, S.F.; Dubey, G.S.; Rasaiah, J.C.

    1997-01-01

    Gibbs ensemble simulations are reported for Lennard-Jones particles with embedded quadrupoles of strength Q * =Q/(εσ 5 ) 1/2 =2.0 where ε and σ are the Lennard-Jones parameters. Calculations revealing the effect of the dispersive forces on the liquid endash vapor coexistence were carried out by scaling the attractive r -6 term in the Lennard-Jones pair potential by a factor λ ranging from 0 to 1. Liquid endash vapor coexistence is observed for all values of λ including λ=0 for Q * =2.0, unlike the corresponding dipolar fluid studied by van Leeuwen and Smit et al. [Phys. Rev. Lett. 71, 3991 (1993)] which showed no phase transition below λ=0.35 when the reduced dipole moment μ * =2.0. The simulation data are analyzed to estimate the critical properties of the quadrupolar fluid and their dependence on the strength λ of the dispersive force. The critical temperature and pressure show a clear quadratic dependence on λ, while the density is less confidently identified as being linear in λ. The compressibility is roughly linear in λ. copyright 1997 American Institute of Physics

  6. Thermal structural evolutions of DMPC-water biomimetic systems investigated by Raman Spectroscopy.

    Science.gov (United States)

    Fasanella, A; Cosentino, K; Beneduci, A; Chidichimo, G; Cazzanelli, E; Barberi, R C; Castriota, M

    2018-06-01

    Many cell membranes of living organisms can be represented as phospholipid bilayers immersed into a water environment. The physical-chemical interactions at the membranes/water interface are responsible for the stabilization of the membranes. In addition, the drug efficiency, the pharmaceutical mechanism and the improvement of the drug design can be addressed to the interactions between the membranes-water interface with the drug and to the membrane-drug interface. In this framework, it is important to find membranes models able to simulate and simultaneously simplify the biological systems to better understand both physical and chemical interactions at the interface level. Dimyristoylphosphatidylcholine (DMPC) is a synthetic phospholipid used in order to make Multilamellar Vesicle (MLV), Large Unilamellar Vesicle (LUV) and Giant Unilamellar Vesicle (GUV). In order to understand the mechanisms of vesicle formation, we have analyzed mixtures of DMPC and water by micro-Raman spectroscopy at different temperatures in the range between 10 and 35 °C. Particularly, we analyzed the temperature dependence of the CN vibrational frequency, which appears well correlated to the order degree of the various phases. These investigations, beyond the determination of phospholipid hydrocarbon chains order, provide information about the conformation of the lipid membranes. We have identified the mixture of DMPC/water that is best suited for Raman studies and can be used as an in-vitro model for biological systems. A peculiar frequency shift across the transition gel-ripple-liquid crystalline phases has been proposed as a useful diagnostic marker to detect the "order degree" and subsequently the phases of biomimetic membranes made by DMPC. Copyright © 2018 Elsevier B.V. All rights reserved.

  7. Phase space density representations in fluid dynamics

    International Nuclear Information System (INIS)

    Ramshaw, J.D.

    1989-01-01

    Phase space density representations of inviscid fluid dynamics were recently discussed by Abarbanel and Rouhi. Here it is shown that such representations may be simply derived and interpreted by means of the Liouville equation corresponding to the dynamical system of ordinary differential equations that describes fluid particle trajectories. The Hamiltonian and Poisson bracket for the phase space density then emerge as immediate consequences of the corresponding structure of the dynamics. For barotropic fluids, this approach leads by direct construction to the formulation presented by Abarbanel and Rouhi. Extensions of this formulation to inhomogeneous incompressible fluids and to fluids in which the state equation involves an additional transported scalar variable are constructed by augmenting the single-particle dynamics and phase space to include the relevant additional variable

  8. Synthesis and luminescent spectroscopy of lanthanide complexes with dimethylpyridine-2,6-dicarboxylate (dmpc)

    Energy Technology Data Exchange (ETDEWEB)

    Taha, Ziyad A., E-mail: tahaz33@just.edu.jo [Department of Applied Chemical Sciences, Faculty of Arts and Sciences, Jordan University of Science and Technology, Irbid 22110 (Jordan); Ajlouni, Abdulaziz M.; Hijazi, Ahmed K. [Department of Applied Chemical Sciences, Faculty of Arts and Sciences, Jordan University of Science and Technology, Irbid 22110 (Jordan); Al-Rawashdeh, Nathir A. [Department of Applied Chemical Sciences, Faculty of Arts and Sciences, Jordan University of Science and Technology, Irbid 22110 (Jordan); Department of Chemistry, United Arab Emirates University, Al Ain 15551 (United Arab Emirates); Al-Hassan, Khader A.; Al-Haj, Yaser A. [Department of Chemistry, Faculty of Science, Yarmouk University, 1163 Irbid (Jordan); Ebqa' ai, Mohammad A. [Al-Qunfudah Center For Scientific Research, Umm Al-Qura University, College in Al-Qunfudah, Makkah (Saudi Arabia); Altalafha, Ammar Y. [Department of Chemistry, Faculty of Science, Yarmouk University, 1163 Irbid (Jordan)

    2015-05-15

    A series of lanthanide complexes with the general formulae [Ln(dmpc)(NO{sub 3}){sub 2}(H{sub 2}O){sub 2}]NO{sub 3} (Ln=Pr, Nd, Sm, Eu, Gd, Tb, Dy, and Er) and [La(dmpc)(NO{sub 3}){sub 2}(H{sub 2}O){sub 2}]NO{sub 3} were prepared by direct reaction between hydrated lanthanide(III) nitrate and dimethylpyridine-2,6-dicarboxylate (dmpc) in a 1:1 M ratio in ethylacetate–chloroform mixture. The luminescence properties of the dmpc and its Ln(III) complexes were investigated in solid state and in methanol, DMF and DMSO solutions. The Tb–dmpc, Eu–dmpc, Sm–dmpc and Dy–dmpc complexes exhibit characteristic luminescence of Tb(III), Eu(III), Sm(III) and Dy(III) ions indicating energy transfer from the dmpc to the Ln(III) ions. Scavenging activities of the dmpc and its Ln(III) complexes on DPPH{sup •} free radical were investigated in DMSO solution at a different concentrations ranges. - Highlights: • Nine new lanthanide complexes with dmpc ligand are prepared and characterized. • Ln–dmpc {Ln=Eu, Tb, Sm, Dy} complexes exhibit characteristic emissions of Ln ions. • The solvent effect on the luminescence intensity is investigated. • The antioxidant activity of the dmpc is enhanced upon complexation with lanthanide.

  9. Thermodynamics phase changes of nanopore fluids

    KAUST Repository

    Islam, Akand W.; Patzek, Tadeusz; Sun, Alexander Y.

    2015-01-01

    The van der Waals (vdW) equation (Eq.) is modified to describe thermodynamic of phase behavior of fluids confined in nanopore. Our aim is to compute pressures exerted by the fluid molecules and to investigate how they change due to pore proximity by assuming the pore wall is inert. No additional scaling of model parameters is imposed and original volume and energy parameters are used in the calculations. Our results clearly show the phase changes due to confinement. The critical shifts of temperatures and pressures are in good agreement compared to the laboratory data and molecular simulation. Peng-Robinson (PR) equation-of-state (EOS) has resulted in different effect than the vdW. This work delivers insights into the nature of fluid behavior in extremely low-permeability nanoporous media, especially in the tight shale reservoirs, below the critical temperatures. © 2015 Elsevier B.V.

  10. Thermodynamics phase changes of nanopore fluids

    KAUST Repository

    Islam, Akand W.

    2015-07-01

    The van der Waals (vdW) equation (Eq.) is modified to describe thermodynamic of phase behavior of fluids confined in nanopore. Our aim is to compute pressures exerted by the fluid molecules and to investigate how they change due to pore proximity by assuming the pore wall is inert. No additional scaling of model parameters is imposed and original volume and energy parameters are used in the calculations. Our results clearly show the phase changes due to confinement. The critical shifts of temperatures and pressures are in good agreement compared to the laboratory data and molecular simulation. Peng-Robinson (PR) equation-of-state (EOS) has resulted in different effect than the vdW. This work delivers insights into the nature of fluid behavior in extremely low-permeability nanoporous media, especially in the tight shale reservoirs, below the critical temperatures. © 2015 Elsevier B.V.

  11. Phase equilibria in chemical reactive fluid mixtures

    International Nuclear Information System (INIS)

    Maurer, Gerd

    2011-01-01

    Downstream processing is a major part of nearly all processes in the chemical industries. Most separation processes in the chemical (and related) industries for fluid mixtures are based on phase equilibrium phenomena. The majority of separation processes can be modelled assuming that chemical reactions are of no (or very minor) importance, i.e., assuming that the overall speciation remains unchanged during a separation process. However, there are also a large number of industrially important processes where the thermodynamic properties are influenced by chemical reactions. The phase equilibrium of chemical reactive mixtures has been a major research area of the author's group over nearly 40 years. In this contribution, three examples from that research are discussed. The first example deals with the vapour phase dimerisation of carboxylic acids and its consequences on phase equilibrium phenomena and phase equilibrium predictions. The second example deals with the solubility of sour gases (e.g., carbon dioxide and sulfur dioxide) in aqueous solutions of ammonia. That topic has been of interest for many years, e.g., in relation with the gasification and liquefaction of coal and, more recently, with the removal of carbon dioxide from flue gas in the 'chilled ammonia process'. The third example deals with phase equilibrium phenomena in aqueous solutions of polyelectrolytes. It deals with the phenomenon of 'counter ion condensation' and methods to model the Gibbs free energy of such solutions.

  12. High-pressure fluid phase equilibria phenomenology and computation

    CERN Document Server

    Deiters, Ulrich K

    2012-01-01

    The book begins with an overview of the phase diagrams of fluid mixtures (fluid = liquid, gas, or supercritical state), which can show an astonishing variety when elevated pressures are taken into account; phenomena like retrograde condensation (single and double) and azeotropy (normal and double) are discussed. It then gives an introduction into the relevant thermodynamic equations for fluid mixtures, including some that are rarely found in modern textbooks, and shows how they can they be used to compute phase diagrams and related properties. This chapter gives a consistent and axiomatic approach to fluid thermodynamics; it avoids using activity coefficients. Further chapters are dedicated to solid-fluid phase equilibria and global phase diagrams (systematic search for phase diagram classes). The appendix contains numerical algorithms needed for the computations. The book thus enables the reader to create or improve computer programs for the calculation of fluid phase diagrams. introduces phase diagram class...

  13. Phase coexistence properties of polarizable Stockmayer fluids

    International Nuclear Information System (INIS)

    Kiyohara, K.; Gubbins, K.E.; Panagiotopoulos, A.Z.

    1997-01-01

    We report the phase coexistence properties of polarizable Stockmayer fluids of reduced permanent dipoles |m 0 * |= 1.0 and 2.0 and reduced polarizabilities α * = 0.00, 0.03, and 0.06, calculated by a series of grand canonical Monte Carlo simulations with the histogram reweighting method. In the histogram reweighting method, the distributions of density and energy calculated in Grand Canonical Monte Carlo simulations are stored in histograms and analyzed to construct the grand canonical partition function of the system. All thermodynamic properties are calculated from the grand partition function. The results are compared with Wertheim close-quote s renormalization perturbation theory. Deviations between theory and simulation results for the coexistence envelope are near 2% for the lower dipole moment and 10% for the higher dipole moment we studied. copyright 1997 American Institute of Physics

  14. Phase transitions of fluids in heterogeneous pores

    Directory of Open Access Journals (Sweden)

    A. Malijevský

    2016-03-01

    Full Text Available We study phase behaviour of a model fluid confined between two unlike parallel walls in the presence of long range (dispersion forces. Predictions obtained from macroscopic (geometric and mesoscopic arguments are compared with numerical solutions of a non-local density functional theory. Two capillary models are considered. For a capillary comprising two (differently adsorbing walls we show that simple geometric arguments lead to the generalized Kelvin equation locating very accurately capillary condensation, provided both walls are only partially wet. If at least one of the walls is in complete wetting regime, the Kelvin equation should be modified by capturing the effect of thick wetting films by including Derjaguin's correction. Within the second model, we consider a capillary formed of two competing walls, so that one tends to be wet and the other dry. In this case, an interface localized-delocalized transition occurs at bulk two-phase coexistence and a temperature T*(L depending on the pore width L. A mean-field analysis shows that for walls exhibiting first-order wetting transition at a temperature T_{w}, T_{s} > T*(L > T_{w}, where the spinodal temperature Ts can be associated with the prewetting critical temperature, which also determines a critical pore width below which the interface localized-delocalized transition does not occur. If the walls exhibit critical wetting, the transition is shifted below Tw and for a model with the binding potential W(l=A(Tl-2+B(Tl-3+..., where l is the location of the liquid-gas interface, the transition can be characterized by a dimensionless parameter κ=B/(AL, so that the fluid configuration with delocalized interface is stable in the interval between κ=-2/3 and κ ~ -0.23.

  15. Novel Fluid Preservation System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — To address NASA's need for a method to preserve blood and urine samples from astronauts collected during flight, Chromologic (CL) proposes to develop a novel Fluid...

  16. Fluid phases of hydrogen-bound states and thermodynamical properties

    International Nuclear Information System (INIS)

    Ebeling, W.; Kraeft, W.D.

    1985-08-01

    The fluid phases of hydrogen and especially the existence of two critical points, the density dependence of the two - particle states and the effective interactions are discussed. An effective Schroedinger equation and a Saha equation are given. (author)

  17. Thermo-Fluid Dynamics of Two-Phase Flow

    CERN Document Server

    Ishii, Mamrou

    2011-01-01

    "Thermo-fluid Dynamics of Two-Phase Flow, Second Edition" is focused on the fundamental physics of two-phase flow. The authors present the detailed theoretical foundation of multi-phase flow thermo-fluid dynamics as they apply to: Nuclear reactor transient and accident analysis; Energy systems; Power generation systems; Chemical reactors and process systems; Space propulsion; Transport processes. This edition features updates on two-phase flow formulation and constitutive equations and CFD simulation codes such as FLUENT and CFX, new coverage of the lift force model, which is of part

  18. Strong Static Magnetic Fields Increase the Gel Signal in Partially Hydrated DPPC/DMPC Membranes.

    Science.gov (United States)

    Tang, Jennifer; Alsop, Richard J; Schmalzl, Karin; Epand, Richard M; Rheinstädter, Maikel C

    2015-09-29

    NIt was recently reported that static magnetic fields increase lipid order in the hydrophobic membrane core of dehydrated native plant plasma membranes [Poinapen, Soft Matter 9:6804-6813, 2013]. As plasma membranes are multicomponent, highly complex structures, in order to elucidate the origin of this effect, we prepared model membranes consisting of a lipid species with low and high melting temperature. By controlling the temperature, bilayers coexisting of small gel and fluid domains were prepared as a basic model for the plasma membrane core. We studied molecular order in mixed lipid membranes made of dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) using neutron diffraction in the presence of strong static magnetic fields up to 3.5 T. The contribution of the hydrophobic membrane core was highlighted through deuterium labeling the lipid acyl chains. There was no observable effect on lipid organization in fluid or gel domains at high hydration of the membranes. However, lipid order was found to be enhanced at a reduced relative humidity of 43%: a magnetic field of 3.5 T led to an increase of the gel signal in the diffraction patterns of 5%. While all biological materials have weak diamagnetic properties, the corresponding energy is too small to compete against thermal disorder or viscous effects in the case of lipid molecules. We tentatively propose that the interaction between the fatty acid chains' electric moment and the external magnetic field is driving the lipid tails in the hydrophobic membrane core into a better ordered state.

  19. Strong Static Magnetic Fields Increase the Gel Signal in Partially Hydrated DPPC/DMPC Membranes

    Directory of Open Access Journals (Sweden)

    Jennifer Tang

    2015-09-01

    Full Text Available NIt was recently reported that static magnetic fields increase lipid order in the hydrophobic membrane core of dehydrated native plant plasma membranes [Poinapen, Soft Matter 9:6804-6813, 2013]. As plasma membranes are multicomponent, highly complex structures, in order to elucidate the origin of this effect, we prepared model membranes consisting of a lipid species with low and high melting temperature. By controlling the temperature, bilayers coexisting of small gel and fluid domains were prepared as a basic model for the plasma membrane core. We studied molecular order in mixed lipid membranes made of dimyristoyl-sn-glycero-3-phosphocholine (DMPC and dipalmitoyl-sn-glycero-3-phosphocholine (DPPC using neutron diffraction in the presence of strong static magnetic fields up to 3.5 T. The contribution of the hydrophobic membrane core was highlighted through deuterium labeling the lipid acyl chains. There was no observable effect on lipid organization in fluid or gel domains at high hydration of the membranes. However, lipid order was found to be enhanced at a reduced relative humidity of 43%: a magnetic field of 3.5 T led to an increase of the gel signal in the diffraction patterns of 5%. While all biological materials have weak diamagnetic properties, the corresponding energy is too small to compete against thermal disorder or viscous effects in the case of lipid molecules. We tentatively propose that the interaction between the fatty acid chains’ electric moment and the external magnetic field is driving the lipid tails in the hydrophobic membrane core into a better ordered state.

  20. Structural features and functional properties of water in model DMPC membranes: thermally stimulated depolarization currents (TSDCs) and Fourier transform infrared (FTIR) studies

    Science.gov (United States)

    Bridelli, M. G.; Capelletti, R.; Mora, C.

    2013-12-01

    Thermally stimulated depolarization currents (TSDCs) and Fourier transform infrared (FTIR) spectroscopies were employed to investigate the state of water incorporated in a model DMPC (dimyristoyl-phosphatidylcholine) membrane. The lipid multilayers, highly inhomogeneous from the dielectric point of view, originate complex TSDC spectra critically dependent on the sample water content and thermal history. Different temperature ranges were chosen to polarize the sample, i.e. 100-300 K (type I) and 100-285 K (type II). The purpose of the latter choice was to avoid any sample heating above the DMPC phase transition temperature (295 K) along the sample polarization. According to the results, water in a fully hydrated system (aw = 0.92) (1) is ordered around the hydrophilic head molecular groups, (2) is layered in the interbilayer space and (3) penetrates among the hydrocarbon chains. It can assume different local structural configurations depending on the lipid packing. Irreversible conformational transitions in the lipid array system were monitored as a consequence of different dehydration treatments. FTIR absorption measurements were performed to study the water sorption kinetics into a DMPC thin film. The water related OH band was decomposed into three components, describing three water states, with different propensity to the H-bond formation. The changes of the lipid characteristic groups (CH2/CH3, PO_{2}^{-} and C=O) absorption bands as a function of increasing hydration level were monitored and discussed.

  1. Structural features and functional properties of water in model DMPC membranes: thermally stimulated depolarization currents (TSDCs) and Fourier transform infrared (FTIR) studies

    International Nuclear Information System (INIS)

    Bridelli, M G; Capelletti, R; Mora, C

    2013-01-01

    Thermally stimulated depolarization currents (TSDCs) and Fourier transform infrared (FTIR) spectroscopies were employed to investigate the state of water incorporated in a model DMPC (dimyristoyl-phosphatidylcholine) membrane. The lipid multilayers, highly inhomogeneous from the dielectric point of view, originate complex TSDC spectra critically dependent on the sample water content and thermal history. Different temperature ranges were chosen to polarize the sample, i.e. 100–300 K (type I) and 100–285 K (type II). The purpose of the latter choice was to avoid any sample heating above the DMPC phase transition temperature (295 K) along the sample polarization. According to the results, water in a fully hydrated system (a w  = 0.92) (1) is ordered around the hydrophilic head molecular groups, (2) is layered in the interbilayer space and (3) penetrates among the hydrocarbon chains. It can assume different local structural configurations depending on the lipid packing. Irreversible conformational transitions in the lipid array system were monitored as a consequence of different dehydration treatments. FTIR absorption measurements were performed to study the water sorption kinetics into a DMPC thin film. The water related OH band was decomposed into three components, describing three water states, with different propensity to the H-bond formation. The changes of the lipid characteristic groups (CH 2 /CH 3 , PO 2 − and C=O) absorption bands as a function of increasing hydration level were monitored and discussed. (paper)

  2. A Thermodynamically Consistent Approach to Phase-Separating Viscous Fluids

    Science.gov (United States)

    Anders, Denis; Weinberg, Kerstin

    2018-04-01

    The de-mixing properties of heterogeneous viscous fluids are determined by an interplay of diffusion, surface tension and a superposed velocity field. In this contribution a variational model of the decomposition, based on the Navier-Stokes equations for incompressible laminar flow and the extended Korteweg-Cahn-Hilliard equations, is formulated. An exemplary numerical simulation using C1-continuous finite elements demonstrates the capability of this model to compute phase decomposition and coarsening of the moving fluid.

  3. Geometry-induced phase transition in fluids: Capillary prewetting

    OpenAIRE

    Yatsyshin, Petr; Savva, Nikos; Kalliadasis, Serafim

    2013-01-01

    We report a new first-order phase transition preceding capillary condensation and corresponding to the discontinuous formation of a curved liquid meniscus. Using a mean-field microscopic approach based on the density functional theory we compute the complete phase diagram of a prototypical two-dimensional system exhibiting capillary condensation, namely that of a fluid with long-ranged dispersion intermolecular forces which is spatially confined by a substrate forming a semi-infinite rectangu...

  4. Lattice Boltzmann model for three-phase viscoelastic fluid flow

    Science.gov (United States)

    Xie, Chiyu; Lei, Wenhai; Wang, Moran

    2018-02-01

    A lattice Boltzmann (LB) framework is developed for simulation of three-phase viscoelastic fluid flows in complex geometries. This model is based on a Rothman-Keller type model for immiscible multiphase flows which ensures mass conservation of each component in porous media even for a high density ratio. To account for the viscoelastic effects, the Maxwell constitutive relation is correctly introduced into the momentum equation, which leads to a modified lattice Boltzmann evolution equation for Maxwell fluids by removing the normal but excess viscous term. Our simulation tests indicate that this excess viscous term may induce significant errors. After three benchmark cases, the displacement processes of oil by dispersed polymer are studied as a typical example of three-phase viscoelastic fluid flow. The results show that increasing either the polymer intrinsic viscosity or the elastic modulus will enhance the oil recovery.

  5. Diffusion in porous structures containing three fluid phases

    International Nuclear Information System (INIS)

    Galani, A.N.; Kainourgiakis, M.E.; Stubos, A.K.; Kikkinides, E.S.

    2005-01-01

    In the present study, the tracer diffusion in porous media filled by three fluid phases (a non-wetting, an intermediate wetting and a wetting phase) is investigated. The disordered porous structure of porous systems like random sphere packing and the North Sea chalk, is represented by three-dimensional binary images. The random sphere pack is generated by a standard ballistic deposition procedure, while the chalk matrix by a stochastic reconstruction technique. Physically sound spatial distributions of the three phases filling the pore space are determined by the use of a simulated annealing algorithm, where those phases are initially randomly distributed in the pore space and trial-and-error swaps are performed in order to attain the global minimum of the total interfacial energy. The acceptance rule for a trial move during the annealing is modified properly improving the efficiency of the technique. The diffusivities of the resulting domains are computed by a random walk method. A parametric study with respect to the pore volume fraction occupied by each fluid phase and the ratio of the diffusivities in the fluid phases is performed. (authors)

  6. Mass transfer processes in crystalline aggregates containing a fluid phase

    NARCIS (Netherlands)

    Visser, H.J.M.

    1999-01-01

    Understanding mass transfer processes in porous crystalline aggregates containing a fluid phase is of major importance for modelling partially molten regions of the Earth's mantle, such as those under mid-ocean spreading ridges. Despite the fact that mid-ocean ridges can be considered the

  7. Mass transfer processes in crystalline aggregates containing a fluid phase

    NARCIS (Netherlands)

    Visser, H.J.M.

    1999-01-01

    Understanding mass transfer processes in porous crystalline aggregates containing a fluid phase is of major importance for modelling partially molten regions of the Earth's mantle, such as those under mid-ocean spreading ridges. Despite the fact that mid-ocean ridges can be considered the simplest

  8. Fluid-elastic vibration in two-phase cross flow

    International Nuclear Information System (INIS)

    Sasakawa, T.; Serizawa, A.; Kawara, Z.

    2003-01-01

    The present work aims at clarifying the mechanisms of fluid elastic vibration of tube bundles in two-phase cross flow. The experiment is conducted using air-water two-phase flow under atmospheric pressure. The test section is a 1.03m long transparent acrylic square duct with 128 x 128 mm 2 cross section, which consists of 3 rod-rows with 5 rods in each row. The rods are 125mm long aluminum rods with 22 mm in diameter (p/D=1.45). The natural frequency of rod vibration is about 30Hz. The result indicated a diversion of observed trend in vibration behavior depending on two-phase flow patterns either bubbly flow or churn flow. Specifically, in churn flow, the fluid elastic vibration has been observed to occur when the frequency in void fraction fluctuation approached to the natural frequency of the rods, but this was not the case in fluid elastic vibration in bubbly flow. This fact suggests the existence of mechanisms closely coupled with two-phase flow structures depending on the flow patterns, that is, static two-phase character-controlled mechanism in bubbly flow and dynamic character- controlled in churn flow

  9. Uniform phases in fluids of hard isosceles triangles: One-component fluid and binary mixtures

    Science.gov (United States)

    Martínez-Ratón, Yuri; Díaz-De Armas, Ariel; Velasco, Enrique

    2018-05-01

    We formulate the scaled particle theory for a general mixture of hard isosceles triangles and calculate different phase diagrams for the one-component fluid and for certain binary mixtures. The fluid of hard triangles exhibits a complex phase behavior: (i) the presence of a triatic phase with sixfold symmetry, (ii) the isotropic-uniaxial nematic transition is of first order for certain ranges of aspect ratios, and (iii) the one-component system exhibits nematic-nematic transitions ending in critical points. We found the triatic phase to be stable not only for equilateral triangles but also for triangles of similar aspect ratios. We focus the study of binary mixtures on the case of symmetric mixtures: equal particle areas with aspect ratios (κi) symmetric with respect to the equilateral one, κ1κ2=3 . For these mixtures we found, aside from first-order isotropic-nematic and nematic-nematic transitions (the latter ending in a critical point): (i) a region of triatic phase stability even for mixtures made of particles that do not form this phase at the one-component limit, and (ii) the presence of a Landau point at which two triatic-nematic first-order transitions and a nematic-nematic demixing transition coalesce. This phase behavior is analogous to that of a symmetric three-dimensional mixture of rods and plates.

  10. Fluid dynamics of cryogenic two-phase flows

    International Nuclear Information System (INIS)

    Verfondern, K.; Jahn, W.

    2004-01-01

    The objective of this study was to examine the flow behavior of a methane hydrate/methane-liquid hydrogen dispersed two-phase fluid through a given design of a moderator chamber for the ESS target system. The calculations under simplified conditions, e.g., taking no account of heat input from outside, have shown that the computer code used, CFX, was able to simulate the behavior of the two-phase flow through the moderator chamber, producing reasonable results up to a certain level of the solid phase fraction, that allowed a continuous flow process through the chamber. Inlet flows with larger solid phase fractions than 40 vol% were found to be a ''problem'' for the computer code. From the computer runs based on fractions between 20 and 40 vol%, it was observed that with increasing solid phase fraction at the inlet, the resulting flow pattern revealed a strong tendency for blockage within the chamber, supported by the ''heavy weight'' of the pellets compared to the carrying liquid. Locations which are prone to the development of such uneven flow behavior are the areas around the turning points in the semispheres and near the exit of the moderator. The considered moderator chamber with horizontal inlet and outlet flow for a solid-liquid two-phase fluid does not seem to be an appropriate design. (orig.)

  11. Geometry-induced phase transition in fluids: capillary prewetting.

    Science.gov (United States)

    Yatsyshin, Petr; Savva, Nikos; Kalliadasis, Serafim

    2013-02-01

    We report a new first-order phase transition preceding capillary condensation and corresponding to the discontinuous formation of a curved liquid meniscus. Using a mean-field microscopic approach based on the density functional theory we compute the complete phase diagram of a prototypical two-dimensional system exhibiting capillary condensation, namely that of a fluid with long-ranged dispersion intermolecular forces which is spatially confined by a substrate forming a semi-infinite rectangular pore exerting long-ranged dispersion forces on the fluid. In the T-μ plane the phase line of the new transition is tangential to the capillary condensation line at the capillary wetting temperature T(cw). The surface phase behavior of the system maps to planar wetting with the phase line of the new transition, termed capillary prewetting, mapping to the planar prewetting line. If capillary condensation is approached isothermally with T>T(cw), the meniscus forms at the capping wall and unbinds continuously, making capillary condensation a second-order phenomenon. We compute the corresponding critical exponent for the divergence of adsorption.

  12. Coupling two-phase fluid flow with two-phase darcy flow in anisotropic porous media

    KAUST Repository

    Chen, J.

    2014-06-03

    This paper reports a numerical study of coupling two-phase fluid flow in a free fluid region with two-phase Darcy flow in a homogeneous and anisotropic porous medium region. The model consists of coupled Cahn-Hilliard and Navier-Stokes equations in the free fluid region and the two-phase Darcy law in the anisotropic porous medium region. A Robin-Robin domain decomposition method is used for the coupled Navier-Stokes and Darcy system with the generalized Beavers-Joseph-Saffman condition on the interface between the free flow and the porous media regions. Obtained results have shown the anisotropic properties effect on the velocity and pressure of the two-phase flow. 2014 Jie Chen et al.

  13. Coupling Two-Phase Fluid Flow with Two-Phase Darcy Flow in Anisotropic Porous Media

    Directory of Open Access Journals (Sweden)

    Jie Chen

    2014-06-01

    Full Text Available This paper reports a numerical study of coupling two-phase fluid flow in a free fluid region with two-phase Darcy flow in a homogeneous and anisotropic porous medium region. The model consists of coupled Cahn-Hilliard and Navier-Stokes equations in the free fluid region and the two-phase Darcy law in the anisotropic porous medium region. A Robin-Robin domain decomposition method is used for the coupled Navier-Stokes and Darcy system with the generalized Beavers-Joseph-Saffman condition on the interface between the free flow and the porous media regions. Obtained results have shown the anisotropic properties effect on the velocity and pressure of the two-phase flow.

  14. Two-phase flow characteristics of HFC and HCFC fluid

    International Nuclear Information System (INIS)

    Ueno, T.; Matsuda, K.; Kusakabe, T.

    1998-01-01

    Some two-phase flow characteristics of HFC and HCFC fluid have been investigated experimentally. Fluids used in this experiment are HCFC22 (hereinafter called 'R22'), HCFC123 (hereinafter called 'R123') and Mixture of HFC fluid (hereinafter called 'R407C'). The fluid R407C are mixture of HFC32, HFC134a and HFC125, and their concentrations are 23wt%, 52wt% and 25wt%, respectively. This paper presents main flow parameters such as void fraction, interfacial velocities, bubble diameter distribution and pressure drop multiplier, which can characterize flow behavior. The void fractions and interfacial velocities were measured at some local positions in the single pipe using the bi-optical probe(hereinafter called 'BOP'). The procedure to calculate the void fraction from the void signals obtained by BOP were adopted the so-called slice method. The effects of slice levels on the void fraction were discussed taking into account bubble diameter. The new correlation of slice level as the function of void fraction has been proposed. The area-averaged void fractions obtained from BOP's void signals using new correlation were compared with void fractions obtained from pressure drops. The area-averaged interfacial velocities were also compared with the superficial gas velocities. It was concluded that the accuracy of BOP measurements are 5% for void fraction and less than 8.5% for interfacial velocity

  15. Immiscible two-phase fluid flows in deformable porous media

    Science.gov (United States)

    Lo, Wei-Cheng; Sposito, Garrison; Majer, Ernest

    Macroscopic differential equations of mass and momentum balance for two immiscible fluids in a deformable porous medium are derived in an Eulerian framework using the continuum theory of mixtures. After inclusion of constitutive relationships, the resulting momentum balance equations feature terms characterizing the coupling among the fluid phases and the solid matrix caused by their relative accelerations. These terms, which imply a number of interesting phenomena, do not appear in current hydrologic models of subsurface multiphase flow. Our equations of momentum balance are shown to reduce to the Berryman-Thigpen-Chen model of bulk elastic wave propagation through unsaturated porous media after simplification (e.g., isothermal conditions, neglect of gravity, etc.) and under the assumption of constant volume fractions and material densities. When specialized to the case of a porous medium containing a single fluid and an elastic solid, our momentum balance equations reduce to the well-known Biot model of poroelasticity. We also show that mass balance alone is sufficient to derive the Biot model stress-strain relations, provided that a closure condition for porosity change suggested by de la Cruz and Spanos is invoked. Finally, a relation between elastic parameters and inertial coupling coefficients is derived that permits the partial differential equations of the Biot model to be decoupled into a telegraph equation and a wave equation whose respective dependent variables are two different linear combinations of the dilatations of the solid and the fluid.

  16. Molecular packing in 1-hexanol-DMPC bilayers studied by molecular dynamics simulation

    DEFF Research Database (Denmark)

    Pedersen, U.R.; Peters, Günther H.j.; Westh, P.

    2007-01-01

    The structure and molecular packing density of a “mismatched” solute, 1-hexanol, in lipid membranes of dimyristoyl phosphatidylcholine (DMPC) was studied by molecular dynamics simulations. We found that the average location and orientation of the hexanol molecules matched earlier experimental data...... on comparable systems. The local density or molecular packing in DMPC–hexanol was elucidated through the average Voronoi volumes of all heavy (non-hydrogen) atoms. Analogous analysis was conducted on trajectories from simulations of pure 1-hexanol and pure (hydrated) DMPC bilayers. The results suggested...... of the alcohol upon partitioning and an even stronger loosening in the packing of the lipid. Furthermore, analysis of Voronoi volumes along the membrane normal identifies a distinctive depth dependence of the changes in molecular packing. The outer (interfacial) part of the lipid acyl chains (up to C8...

  17. SANS study of the unilamellar DMPC vesicles. The fluctuation model of lipid bilayer

    International Nuclear Information System (INIS)

    Kiselev, M.A.; Zemlyanaya, E.V.; Vinod, A.

    2003-01-01

    On the basis of the separated form-factors model, parameters of the polydispersed unilamellar DMPC vesicle population are analyzed. The neutron scattering length density across the membrane is simulated on the basis of fluctuated model of lipid bilayer. The hydration of vesicle is described by sigmoid distribution function of the water molecules. The results of fitting of the experimental data obtained at the small angle spectrometer SANS-I, PSI (Switzerland) are: average vesicle radius 272±0.4 Armstrong, polydispersity of the radius 27 %, membrane thickness 50.6± Armstrong, thickness of hydrocarbon chain region 21.4±2.8 Armstrong, number of water molecules located per lipid molecule 13±1, and DMPC surface area 59±2 Armstrong 2 . The calculated water distribution function across the bilayer directly explains why lipid membrane is easy penetrated by water molecules

  18. Phase separation in fluids exposed to spatially periodic external fields.

    Science.gov (United States)

    Vink, R L C; Archer, A J

    2012-03-01

    When a fluid is confined within a spatially periodic external field, the liquid-vapor transition is replaced by a different transition called laser-induced condensation (LIC) [Götze et al., Mol. Phys. 101, 1651 (2003)]. In d=3 dimensions, the periodic field induces an additional phase, characterized by large density modulations along the field direction. At the triple point, all three phases (modulated, vapor, and liquid) coexist. At temperatures slightly above the triple point and for low (high) values of the chemical potential, two-phase coexistence between the modulated phase and the vapor (liquid) is observed; by increasing the temperature further, both coexistence regions terminate in critical points. In this paper, we reconsider LIC using the Ising model to resolve a number of open issues. To be specific, we (1) determine the universality class of the LIC critical points and elucidate the nature of the correlations along the field direction, (2) present a mean-field analysis to show how the LIC phase diagram changes as a function of the field wavelength and amplitude, (3) develop a simulation method by which the extremely low tension of the interface between modulated and vapor or liquid phase can be measured, (4) present a finite-size scaling analysis to accurately extract the LIC triple point from finite-size simulation data, and (5) consider the fate of LIC in d=2 dimensions.

  19. Membrane self assembly in mixed DMPC/NaC systems by SANS

    International Nuclear Information System (INIS)

    Kiselev, M.A.; Lombardo, D.; Lesieur, P.; Kisselev, A.M.; Borbely, S.; Simonova, T.N.; Barsukov, L.I.

    2008-01-01

    Morphological transition in a mixed system of the dimyristoylphosphatidylcholine (DMPC)/sodium cholate (NaC) has been investigated by small-angle scattering of neutron (SANS) and X-ray (SAXS). Structural investigation, performed as a function of temperature and NaC concentration, show that the system containing 15 mM DMPC and 6 mM NaC reveals a strong dependence of SANS spectra on the temperature. The morphological transformations has been interpreted as a micelle-to-vesicle transition which is induced by the temperature variation (TI-MVT). The main features of the obtained results show that the temperature effect are far less profound in the system containing 2 or 12 mM NaC and can be assigned to small morfological changes within the same population of particles (vesicular or micellar, respectively). The main features of the structural analysis suggest that structural transformations at the TI-MVT proceed in the following sequence: globular micelles - rod-like micelles - polymer-like micelles - unilamellar vesicles. More specifically the globular and rod like micelles present an ellipsoidal cross-section rather than circular one, the former being geometrically more favourable for accommodation of bilayer-forming molecules like DMPC into the micellar structures

  20. Dynamic Studies of Lung Fluid Clearance with Phase Contrast Imaging

    International Nuclear Information System (INIS)

    Kitchen, Marcus J.; Williams, Ivan; Irvine, Sarah C.; Morgan, Michael J.; Paganin, David M.; Lewis, Rob A.; Pavlov, Konstantin; Hooper, Stuart B.; Wallace, Megan J.; Siu, Karen K. W.; Yagi, Naoto; Uesugi, Kentaro

    2007-01-01

    Clearance of liquid from the airways at birth is a poorly understood process, partly due to the difficulties of observing and measuring the distribution of air within the lung. Imaging dynamic processes within the lung in vivo with high contrast and spatial resolution is therefore a major challenge. However, phase contrast X-ray imaging is able to exploit inhaled air as a contrast agent, rendering the lungs of small animals visible due to the large changes in the refractive index at air/tissue interfaces. In concert with the high spatial resolution afforded by X-ray imaging systems (<100 μm), propagation-based phase contrast imaging is ideal for studying lung development. To this end we have utilized intense, monochromatic synchrotron radiation, together with a fast readout CCD camera, to study fluid clearance from the lungs of rabbit pups at birth. Local rates of fluid clearance have been measured from the dynamic sequences using a single image phase retrieval algorithm

  1. Coalescence preference and droplet size inequality during fluid phase segregation

    Science.gov (United States)

    Roy, Sutapa

    2018-02-01

    Using molecular dynamics simulations and scaling arguments, we investigate the coalescence preference dynamics of liquid droplets in a phase-segregating off-critical, single-component fluid. It is observed that the preferential distance of the product drop from its larger parent, during a coalescence event, gets smaller for large parent size inequality. The relative coalescence position exhibits a power-law dependence on the parent size ratio with an exponent q ≃ 3.1 . This value of q is in strong contrast with earlier reports 2.1 and 5.1 in the literature. The dissimilarity is explained by considering the underlying coalescence mechanisms.

  2. Density and Phase State of a Confined Nonpolar Fluid

    Science.gov (United States)

    Kienle, Daniel F.; Kuhl, Tonya L.

    2016-07-01

    Measurements of the mean refractive index of a spherelike nonpolar fluid, octamethytetracylclosiloxane (OMCTS), confined between mica sheets, demonstrate direct and conclusive experimental evidence of the absence of a first-order liquid-to-solid phase transition in the fluid when confined, which has been suggested to occur from previous experimental and simulation results. The results also show that the density remains constant throughout confinement, and that the fluid is incompressible. This, along with the observation of very large increases (many orders of magnitude) in viscosity during confinement from the literature, demonstrate that the molecular motion is limited by the confining wall and not the molecular packing. In addition, the recently developed refractive index profile correction method, which enables the structural perturbation inherent at a solid-liquid interface and that of a liquid in confinement to be determined independently, was used to show that there was no measurable excess or depleted mass of OMCTS near the mica surface in bulk films or confined films of only two molecular layers.

  3. Coupling two-phase fluid flow with two-phase darcy flow in anisotropic porous media

    KAUST Repository

    Chen, J.; Sun, S.; Chen, Z.

    2014-01-01

    in the free fluid region and the two-phase Darcy law in the anisotropic porous medium region. A Robin-Robin domain decomposition method is used for the coupled Navier-Stokes and Darcy system with the generalized Beavers-Joseph-Saffman condition

  4. Thermodynamic Property Model of Wide-Fluid Phase Propane

    Directory of Open Access Journals (Sweden)

    I Made Astina

    2007-05-01

    Full Text Available A new thermodynamic property model for propane is expressed in form of the Helmholtz free energy function. It consists of eight terms of the ideal-gas part and eighteen terms of the residual part. Accurate experimental data of fluid properties and theoretical approach from the intermolecular potential were simultaneously considered in the development to insure accuracy and to improve reliability of the equation of state over wide range of pressures and temperatures. Based on the state range of experimental data used in the model development, the validity range is judged from the triple-point of 85.48 K to temperature of 450 K and pressure up to 60 MPa. The uncertainties with respect to different properties are estimated to be 0.03% in ideal-gas isobaric specific heat, 0.2% in liquid phase density, 0.3% in gaseous phase density 1% in specific heats, 0.1% in vapor-pressure except at very low temperatures, 0.05% in saturated-liquid density, 0.02% in speed of sound of the gaseous phase and 1% in speed of sound of the liquid phase.

  5. Numerical simulation of complex multi-phase fluid of casting process and its applications

    Directory of Open Access Journals (Sweden)

    CHEN Li-liang

    2006-05-01

    Full Text Available The fluid of casting process is a typical kind of multi-phase flow. Actually, many casting phenomena have close relationship with the multi-phase flow, such as molten metal filling process, air entrapment, slag movement, venting process of die casting, gas escaping of lost foam casting and so on. Obviously, in order to analyze these phenomena accurately, numerical simulation of the multi-phase fluid is necessary. Unfortunately, so far, most of the commercial casting simulation systems do not have the ability of multi-phase flow modeling due to the difficulty in the multi-phase flow calculation. In the paper, Finite Different Method (FDM technique was adopt to solve the multi-phase fluid model. And a simple object of the muiti-phase fluid was analyzed to obtain the fluid rates of the liquid phase and the entrapped air phase.

  6. Dynamic dielectrophoresis model of multi-phase ionic fluids.

    Directory of Open Access Journals (Sweden)

    Ying Yan

    Full Text Available Ionic-based dielectrophoretic microchips have attracted significant attention due to their wide-ranging applications in electro kinetic and biological experiments. In this work, a numerical method is used to simulate the dynamic behaviors of ionic droplets in a microchannel under the effect of dielectrophoresis. When a discrete liquid dielectric is encompassed within a continuous fluid dielectric placed in an electric field, an electric force is produced due to the dielectrophoresis effect. If either or both of the fluids are ionic liquids, the magnitude and even the direction of the force will be changed because the net ionic charge induced by an electric field can affect the polarization degree of the dielectrics. However, using a dielectrophoresis model, assuming ideal dielectrics, results in significant errors. To avoid the inaccuracy caused by the model, this work incorporates the electrode kinetic equation and defines a relationship between the polarization charge and the net ionic charge. According to the simulation conditions presented herein, the electric force obtained in this work has an error exceeding 70% of the actual value if the false effect of net ionic charge is not accounted for, which would result in significant issues in the design and optimization of experimental parameters. Therefore, there is a clear motivation for developing a model adapted to ionic liquids to provide precise control for the dielectrophoresis of multi-phase ionic liquids.

  7. Dynamic dielectrophoresis model of multi-phase ionic fluids.

    Science.gov (United States)

    Yan, Ying; Luo, Jing; Guo, Dan; Wen, Shizhu

    2015-01-01

    Ionic-based dielectrophoretic microchips have attracted significant attention due to their wide-ranging applications in electro kinetic and biological experiments. In this work, a numerical method is used to simulate the dynamic behaviors of ionic droplets in a microchannel under the effect of dielectrophoresis. When a discrete liquid dielectric is encompassed within a continuous fluid dielectric placed in an electric field, an electric force is produced due to the dielectrophoresis effect. If either or both of the fluids are ionic liquids, the magnitude and even the direction of the force will be changed because the net ionic charge induced by an electric field can affect the polarization degree of the dielectrics. However, using a dielectrophoresis model, assuming ideal dielectrics, results in significant errors. To avoid the inaccuracy caused by the model, this work incorporates the electrode kinetic equation and defines a relationship between the polarization charge and the net ionic charge. According to the simulation conditions presented herein, the electric force obtained in this work has an error exceeding 70% of the actual value if the false effect of net ionic charge is not accounted for, which would result in significant issues in the design and optimization of experimental parameters. Therefore, there is a clear motivation for developing a model adapted to ionic liquids to provide precise control for the dielectrophoresis of multi-phase ionic liquids.

  8. Fluid dynamics of airlift reactors; Two-phase friction factors

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Calvo, E. (Ingenieria Quimica, Facultad de Ciencias, Univ. de Alcala, 28871 Alcala de Henares (Spain))

    1992-10-01

    Airlift loop reactors (ALR) are useful equipment in biotechnology in a wide range of uses, however their design is not a simple task since prediction of fluid dynamics in these reactors is difficult. Most of the different strategies found in the literature in order to predict two main parameters, namely, gas holdup and liquid velocity, are based on energy or momentum balances. The balances include frictional effects, and it is not yet clear how to predict these effects. The objective of this article is to show how criteria corresponding to one-phase flow may be used in order to predict the frictional effects in ALRs. Based on a model proposed by Garcia-Calvo (1989, 1991), we simulated experimental data of liquid velocity profiles and gas holdup obtained by Young et al. in an ALR with two different configurations. Experimental data obtained in other three external ALRs with different shapes and sizes are also simulated.

  9. Lennard-Jones fluids in two-dimensional nano-pores. Multi-phase coexistence and fluid structure

    Science.gov (United States)

    Yatsyshin, Petr; Savva, Nikos; Kalliadasis, Serafim

    2014-03-01

    We present a number of fundamental findings on the wetting behaviour of nano-pores. A popular model for fluid confinement is a one-dimensional (1D) slit pore formed by two parallel planar walls and it exhibits capillary condensation (CC): a first-order phase transition from vapour to capillary-liquid (Kelvin shift). Capping such a pore at one end by a third orthogonal wall forms a prototypical two-dimensional (2D) pore. We show that 2D pores possess a wetting temperature such that below this temperature CC remains of first order, above it becomes a continuous phase transition manifested by a slab of capillary-liquid filling the pore from the capping wall. Continuous CC exhibits hysteresis and can be preceded by a first-order capillary prewetting transition. Additionally, liquid drops can form in the corners of the 2D pore (remnant of 2D wedge prewetting). The three fluid phases, vapour, capillary-liquid slab and corner drops, can coexist at the pore triple point. Our model is based on the statistical mechanics of fluids in the density functional formulation. The fluid-fluid and fluid-substrate interactions are dispersive. We analyze in detail the microscopic fluid structure, isotherms and full phase diagrams. Our findings also suggest novel ways to control wetting of nano-pores. We are grateful to the European Research Council via Advanced Grant No. 247031 for support.

  10. Particles at fluid-fluid interfaces: A new Navier-Stokes-Cahn-Hilliard surface- phase-field-crystal model.

    Science.gov (United States)

    Aland, Sebastian; Lowengrub, John; Voigt, Axel

    2012-10-01

    Colloid particles that are partially wetted by two immiscible fluids can become confined to fluid-fluid interfaces. At sufficiently high volume fractions, the colloids may jam and the interface may crystallize. The fluids together with the interfacial colloids form an emulsion with interesting material properties and offer an important route to new soft materials. A promising approach to simulate these emulsions was presented in Aland et al. [Phys. Fluids 23, 062103 (2011)], where a Navier-Stokes-Cahn-Hilliard model for the macroscopic two-phase fluid system was combined with a surface phase-field-crystal model for the microscopic colloidal particles along the interface. Unfortunately this model leads to spurious velocities which require very fine spatial and temporal resolutions to accurately and stably simulate. In this paper we develop an improved Navier-Stokes-Cahn-Hilliard-surface phase-field-crystal model based on the principles of mass conservation and thermodynamic consistency. To validate our approach, we derive a sharp interface model and show agreement with the improved diffuse interface model. Using simple flow configurations, we show that the new model has much better properties and does not lead to spurious velocities. Finally, we demonstrate the solid-like behavior of the crystallized interface by simulating the fall of a solid ball through a colloid-laden multiphase fluid.

  11. Evaluating measurement uncertainty in fluid phase equilibrium calculations

    Science.gov (United States)

    van der Veen, Adriaan M. H.

    2018-04-01

    The evaluation of measurement uncertainty in accordance with the ‘Guide to the expression of uncertainty in measurement’ (GUM) has not yet become widespread in physical chemistry. With only the law of the propagation of uncertainty from the GUM, many of these uncertainty evaluations would be cumbersome, as models are often non-linear and require iterative calculations. The methods from GUM supplements 1 and 2 enable the propagation of uncertainties under most circumstances. Experimental data in physical chemistry are used, for example, to derive reference property data and support trade—all applications where measurement uncertainty plays an important role. This paper aims to outline how the methods for evaluating and propagating uncertainty can be applied to some specific cases with a wide impact: deriving reference data from vapour pressure data, a flash calculation, and the use of an equation-of-state to predict the properties of both phases in a vapour-liquid equilibrium. The three uncertainty evaluations demonstrate that the methods of GUM and its supplements are a versatile toolbox that enable us to evaluate the measurement uncertainty of physical chemical measurements, including the derivation of reference data, such as the equilibrium thermodynamical properties of fluids.

  12. Predicting phase shift effects for vibrating fluid-conveying pipes due to Coriolis forces and fluid pulsation

    DEFF Research Database (Denmark)

    Enz, Stephanie; Thomsen, Jon Juel

    2011-01-01

    to improve accuracy, precision, and robustness of CFMs. A simple mathematical model of a fluid-conveying pipe is formulated and the effect of pulsating fluid flow is analyzed using a multiple time scaling perturbation analysis. The results are simple analytical predictions for the transverse pipe...... and uncontrolled during CFM operation by feedback control. The analytical predictions offer an immediate insight into how fluid pulsation affects phase shift, which is a quantity measured by CFMs to estimate the mass flow, and lead to hypotheses for more complex geometries, i.e. industrial CFMs. The validity...... displacement and approximate axial shift in vibration phase. The analytical predictions are tested against pure numerical solution using representative examples, showing good agreement. Fluid pulsations are predicted not to influence CFM accuracy, since proper signal filtering is seen to allow...

  13. Comparison of liquid and supercritical fluid chromatography mobile phases for enantioselective separations on polysaccharide stationary phases.

    Science.gov (United States)

    Khater, Syame; Lozac'h, Marie-Anne; Adam, Isabelle; Francotte, Eric; West, Caroline

    2016-10-07

    Analysis and production of enantiomerically pure compounds is a major topic of interest when active pharmaceutical ingredients are concerned. Enantioselective chromatography has become a favourite both at the analytical and preparative scales. High-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC) are dominating the scene and are often seen as complementary techniques. Nowadays, for economic and ecologic reasons, SFC may be preferred over normal-phase HPLC (NPLC) as it allows significant reductions in solvent consumption. However, the transfer of NPLC methods to SFC is not always straightforward. In this study, we compare the retention of achiral molecules and separation of enantiomers under supercritical fluid (carbon dioxide with ethanol or isopropanol) and liquid normal-phase (heptane with ethanol or isopropanol) elution modes with polysaccharide stationary phases in order to explore the differences between the retention and enantioseparation properties between the two modes. Chemometric methods (namely quantitative structure-retention relationships and discriminant analysis) are employed to compare the results obtained on a large set of analytes (171 achiral probes and 97 racemates) and gain some understanding on the retention and separation mechanisms. The results indicate that, contrary to popular belief, carbon dioxide - solvent SFC mobile phases are often weaker eluents than liquid mobile phases. It appears that SFC and NPLC elution modes provide different retention mechanisms. While some enantioseparations are unaffected, facilitating the transfer between the two elution modes, other enantioseparations may be drastically different due to different types and strength of interactions contributing to enantioselectivity. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Timing, predictors, and progress of third space fluid accumulation during preliminary phase fluid resuscitation in adult patients with dengue.

    Science.gov (United States)

    Premaratna, R; Ragupathy, A; Miththinda, J K N D; de Silva, H J

    2013-07-01

    Fluid leakage remains the hallmark of dengue hemorrhagic fever (DHF). The applicability of currently recommended predictors of DHF for adults with dengue is questionable as these are based on studies conducted in children. One hundred and two adults with dengue were prospectively followed up to investigate whether home-based or hospital-based early phase fluid resuscitation has an impact on clinical and hematological parameters used for the diagnosis of early or critical phase fluid leakage. In the majority of subjects, third space fluid accumulation (TSFA) was detected on the fifth and sixth days of infection. The quantity and quality of fluids administered played no role in TSFA. A reduction in systolic blood pressure appeared to be more helpful than a reduction in pulse pressure in predicting fluid leakage. TSFA occurred with lower percentage rises in packed cell volume (PCV) than stated in the current recommendations. A rapid reduction in platelets, progressive reduction in white blood cells, percentage rises in Haemoglobin (Hb), and PCV, and rises in aspartate aminotransferase and alanine aminotransferase were observed in patients with TSFA and therefore with the development of severe illness. Clinicians should be aware of the limitations of currently recommended predictors of DHF in adult patients who are receiving fluid resuscitation. Copyright © 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  15. Fluid Phase Separation (FPS) experiment for flight on a space shuttle Get Away Special (GAS) canister

    Science.gov (United States)

    Peters, Bruce; Wingo, Dennis; Bower, Mark; Amborski, Robert; Blount, Laura; Daniel, Alan; Hagood, Bob; Handley, James; Hediger, Donald; Jimmerson, Lisa

    1990-01-01

    The separation of fluid phases in microgravity environments is of importance to environmental control and life support systems (ECLSS) and materials processing in space. A successful fluid phase separation experiment will demonstrate a proof of concept for the separation technique and add to the knowledge base of material behavior. The phase separation experiment will contain a premixed fluid which will be exposed to a microgravity environment. After the phase separation of the compound has occurred, small samples of each of the species will be taken for analysis on the Earth. By correlating the time of separation and the temperature history of the fluid, it will be possible to characterize the process. The experiment has been integrated into space available on a manifested Get Away Special (GAS) experiment, CONCAP 2, part of the Consortium for Materials Complex Autonomous Payload (CAP) Program, scheduled for STS-42. The design and the production of a fluid phase separation experiment for rapid implementation at low cost is presented.

  16. Reliable Actuator for Cryo Propellant Fluid Control, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Fluid handling applications in cryogenic and extreme environments require reliable actuation technology that can handle extreme temperatures, mechanical bind-up from...

  17. Principles of fluid management and stewardship in septic shock: it is time to consider the four D's and the four phases of fluid therapy.

    Science.gov (United States)

    Malbrain, Manu L N G; Van Regenmortel, Niels; Saugel, Bernd; De Tavernier, Brecht; Van Gaal, Pieter-Jan; Joannes-Boyau, Olivier; Teboul, Jean-Louis; Rice, Todd W; Mythen, Monty; Monnet, Xavier

    2018-05-22

    In patients with septic shock, the administration of fluids during initial hemodynamic resuscitation remains a major therapeutic challenge. We are faced with many open questions regarding the type, dose and timing of intravenous fluid administration. There are only four major indications for intravenous fluid administration: aside from resuscitation, intravenous fluids have many other uses including maintenance and replacement of total body water and electrolytes, as carriers for medications and for parenteral nutrition. In this paradigm-shifting review, we discuss different fluid management strategies including early adequate goal-directed fluid management, late conservative fluid management and late goal-directed fluid removal. In addition, we expand on the concept of the "four D's" of fluid therapy, namely drug, dosing, duration and de-escalation. During the treatment of patients with septic shock, four phases of fluid therapy should be considered in order to provide answers to four basic questions. These four phases are the resuscitation phase, the optimization phase, the stabilization phase and the evacuation phase. The four questions are "When to start intravenous fluids?", "When to stop intravenous fluids?", "When to start de-resuscitation or active fluid removal?" and finally "When to stop de-resuscitation?" In analogy to the way we handle antibiotics in critically ill patients, it is time for fluid stewardship.

  18. Reliable Actuator for Cryo Propellant Fluid Control, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Cryogenic fluid handling applications require a reliable actuation technology that can handle very low temperatures. A novel EM hammer drive technology is proposed...

  19. Passive Devices for Advanced Fluid Management aboard Spacecraft, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Acute challenges are faced by the designers of fluid systems for spacecraft because of the persistently unfamiliar and unforgiving low-g environment. For example,...

  20. Thermo-fluid dynamics of two-phase flow

    CERN Document Server

    Ishii, Mamoru; Ishii, Mamoru; Ishii, M

    2006-01-01

    Provides a very systematic treatment of two phase flow problems from a theoretical perspectiveProvides an easy to follow treatment of modeling and code devlopemnt of two phase flow related phenomenaCovers new results of two phase flow research such as coverage of fuel cells technology.

  1. Smoothed particle hydrodynamics model for phase separating fluid mixtures. I. General equations

    NARCIS (Netherlands)

    Thieulot, C; Janssen, LPBM; Espanol, P

    We present a thermodynamically consistent discrete fluid particle model for the simulation of a recently proposed set of hydrodynamic equations for a phase separating van der Waals fluid mixture [P. Espanol and C.A.P. Thieulot, J. Chem. Phys. 118, 9109 (2003)]. The discrete model is formulated by

  2. Plasma-treated carbonyl iron particles as a dispersed phase in magnetorheological fluids

    OpenAIRE

    Sedlačík, M.; Pavlínek, V.; Lehocký, M.; Mráček, A.; Grulich, O.; Švrčinová, P. (Petra); Filip, P. (Petr); Vesel, A.

    2011-01-01

    The aim of this paper is to document suitability of plasma-treated carbonyl iron particles as a dispersed phase in magnetorheological fluids. Surface-modified carbonyl iron particles were prepared via their exposure to 50% argon and 50% octafluorocyclobutane plasma. The X-ray photoelectron spectroscopy was used for analysis of chemical bonding states in the surface layer. Plasma-treated particles were adopted for a dispersed phase in magnetorheological (MR) fluids, and the MR behaviour was in...

  3. Fluid-elastic force measurements acting on a tube bundle in two-phase cross flow

    International Nuclear Information System (INIS)

    Inada, Fumio; Kawamura, Koji; Yasuo, Akira

    1996-01-01

    Fluid-elastic force acting on a square tube bundle of P/D = 1.47 in air-water two-phase cross flow was measured to investigate the characteristics and to clarify whether the fluid elastic vibration characteristics could be expressed using two-phase mixture characteristics. Measured fluid elastic forces were separated into fluid-elastic force coefficients such as added mass, added stiffness, and added damping coefficient. The added damping coefficient was separated into a two-phase damping and a flow-dependent component as in previous research (Carlucci, 1981 and 1983; Pettigrew, 1994). These coefficients were nondimensionalized with two-phase mixture characteristics such as void fraction, mixture density and mixture velocity, which were obtained using the drift-flux model with consideration given to the model. The result was compared with the result obtained with the homogeneous model. It was found that fluid-elastic force coefficients could be expressed with two-phase flow mixture characteristics very well in the experimental result, and that better result can be derived using the slip model as compared to the homogeneous model. Added two-phase flow, which could be expressed as a function of void fraction, where two-phase damping was nondimensionalized with the relative velocity between the gas and liquid phases used as a reference velocity. Using these, the added stiffness coefficient and flow-dependent component of damping could be expressed very well as a function of nondimensional mixture velocity

  4. Study of Mururoa's basaltic massif alteration (French Polynesia): solid and fluid phases analysis and thermodynamical modeling

    International Nuclear Information System (INIS)

    Destrigneville, Christine

    1991-01-01

    The alteration processes occurring in the volcanics of Mururoa have been studied using petrological data on secondary minerals, chemical analyses of the interstitial fluids and isotopic analyses on both minerals and fluids. Chemical and isotopic exchanges were first modelled, then thermodynamical modeling characterized the chemical evolution during the alteration of the secondary assemblage and of the fluid. The main secondary sequences which have been observed in Mururoa volcanics result from the alteration occurring during the lavas setting. Two different processes have been evidenced. The first one is the deuteric alteration with the CO_2-rich magmatic fluid exsolved from the magma and trapped in the vesicles and the olivine microcracks of the lava intrusions. This alteration in a closed system is dominated by the solid phases when the CO_2 molar fraction in the fluid is higher than 0.25. The second process is the alteration of the lavas by seawater or a meteoric fluid. The basaltic flows present alteration assemblages composed of clay minerals and zeolites whose chemical composition has been forced by the fluid composition. Shallowness emissions of lavas result in completely argillized levels. The present interstitial fluids chemistry result from the percolation of seawater in the volcano. In the argillized levels the fluids have interacted with the clay minerals and their chemical compositions have been modified. The important chemical changes in the present interstitial fluids show that the present alteration in the volcano is higher than the fluids circulation. (author) [fr

  5. Predicting phase shift of elastic waves in pipes due to fluid flow and imperfections

    DEFF Research Database (Denmark)

    Thomsen, Jon Juel; Dahl, Jonas; Fuglede, Niels

    2009-01-01

    . This is relevant for understanding wave propagation in elastic media in general, and for the design and trouble-shooting of phase-shift measuring devices such as Coriolis mass flowmeters in particular. A multiple time scaling perturbation analysis is employed for a simple model of a fluid-conveying pipe......Flexural vibrations of a fluid-conveying pipe is investigated, with special consideration to the spatial shift in phase caused by fluid flow and various imperfections, e.g., non-ideal supports, non-uniform stiffness or mass, non-proportional damping, weak nonlinearity, and flow pulsation...

  6. Study of the hard-disk system at high densities: the fluid-hexatic phase transition.

    Science.gov (United States)

    Mier-Y-Terán, Luis; Machorro-Martínez, Brian Ignacio; Chapela, Gustavo A; Del Río, Fernando

    2018-06-21

    Integral equations of uniform fluids have been considered unable to predict any characteristic feature of the fluid-solid phase transition, including the shoulder that arises in the second peak of the fluid-phase radial distribution function, RDF, of hard-core systems obtained by computer simulations, at fluid densities very close to the structural two-step phase transition. This reasoning is based on the results of traditional integral approximations, like Percus-Yevick, PY, which does not show such a shoulder in hard-core systems, neither in two nor three dimensions. In this work, we present results of three Ansätze, based on the PY theory, that were proposed to remedy the lack of PY analytical solutions in two dimensions. This comparative study shows that one of those Ansätze does develop a shoulder in the second peak of the RDF at densities very close to the phase transition, qualitatively describing this feature. Since the shoulder grows into a peak at still higher densities, this integral equation approach predicts the appearance of an orientational order characteristic of the hexatic phase in a continuous fluid-hexatic phase transition.

  7. Phase shift effects for fluid conveying pipes with non-ideal supports

    DEFF Research Database (Denmark)

    Dahl, Jonas; Thomsen, Jon Juel

    2008-01-01

    Vibrations of a fluid-conveying pipe with non-ideal supports are investigated with respect to phase shift effects. A numerical Galerkin approach is developed for this general problem, and the use of it exemplified with a investigation of phase shift effects from rotational damping at supports...

  8. MOLECULAR SIMULATION OF PHASE EQUILIBRIA FOR COMPLEX FLUIDS

    Energy Technology Data Exchange (ETDEWEB)

    Athanassios Z. Panagiotopoulos

    2009-09-09

    The general area of this project was the development and application of novel molecular simulation methods for prediction of thermodynamic and structural properties of complex polymeric, surfactant and ionic fluids. Over this project period, we have made considerable progress in developing novel algorithms to meet the computational challenges presented by the strong or long-range interactions in these systems and have generated data for well-defined mod-els that can be used to test theories and compare to experimental data. Overall, 42 archival papers and many invited and contributed presentations and lectures have been based on work supported by this project. 6 PhD, 1 M.S. and 2 postdoctoral students have been associated with this work, as listed in the body of the report.

  9. Molecular Simulation Of Phase Equilibria For Complex Fluids

    International Nuclear Information System (INIS)

    Panagiotopoulos, Athanassios Z.

    2009-01-01

    The general area of this project was the development and application of novel molecular simulation methods for prediction of thermodynamic and structural properties of complex polymeric, surfactant and ionic fluids. Over this project period, we have made considerable progress in developing novel algorithms to meet the computational challenges presented by the strong or long-range interactions in these systems and have generated data for well-defined mod-els that can be used to test theories and compare to experimental data. Overall, 42 archival papers and many invited and contributed presentations and lectures have been based on work supported by this project. 6 PhD, 1 M.S. and 2 postdoctoral students have been associated with this work, as listed in the body of the report.

  10. Phase portrait methods for verifying fluid dynamic simulations

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, H.B.

    1989-01-01

    As computing resources become more powerful and accessible, engineers more frequently face the difficult and challenging engineering problem of accurately simulating nonlinear dynamic phenomena. Although mathematical models are usually available, in the form of initial value problems for differential equations, the behavior of the solutions of nonlinear models is often poorly understood. A notable example is fluid dynamics: while the Navier-Stokes equations are believed to correctly describe turbulent flow, no exact mathematical solution of these equations in the turbulent regime is known. Differential equations can of course be solved numerically, but how are we to assess numerical solutions of complex phenomena without some understanding of the mathematical problem and its solutions to guide us

  11. Introduction to investigations of the negative corona and EHD flow in gaseous two-phase fluids

    Science.gov (United States)

    Jerzy, MIZERACZYK; Artur, BERENDT

    2018-05-01

    Research interests have recently been directed towards electrical discharges in multi-phase environments. Natural electrical discharges, such as lightning and coronas, occur in the Earth’s atmosphere, which is actually a mixture of gaseous phase (air) and suspended solid and liquid particulate matters (PMs). An example of an anthropogenic gaseous multi-phase environment is the flow of flue gas through electrostatic precipitators (ESPs), which are generally regarded as a mixture of a post-combustion gas with solid PM and microdroplets suspended in it. Electrical discharges in multi-phase environments, the knowledge of which is scarce, are becoming an attractive research subject, offering a wide variety of possible discharges and multi-phase environments to be studied. This paper is an introduction to electrical discharges in multi-phase environments. It is focused on DC negative coronas and accompanying electrohydrodynamic (EHD) flows in a gaseous two-phase fluid formed by air (a gaseous phase) and solid PM (a solid phase), run under laboratory conditions. The introduction is based on a review of the relevant literature. Two cases will be considered: the first case is of a gaseous two-phase fluid, initially motionless in a closed chamber before being subjected to a negative corona (with the needle-to-plate electrode arrangement), which afterwards induces an EHD flow in the chamber, and the second, of a gaseous two-phase fluid flowing transversely with respect to the needle-to-plate electrode axis along a chamber with a corona discharge running between the electrodes. This review-based introductory paper should be of interest to theoretical researchers and modellers in the field of negative corona discharges in single- or two-phase fluids, and for engineers who work on designing EHD devices (such as ESPs, EHD pumps, and smoke detectors).

  12. Scrutinization of thermal radiation, viscous dissipation and Joule heating effects on Marangoni convective two-phase flow of Casson fluid with fluid-particle suspension

    Science.gov (United States)

    Mahanthesh, B.; Gireesha, B. J.

    2018-03-01

    The impact of Marangoni convection on dusty Casson fluid boundary layer flow with Joule heating and viscous dissipation aspects is addressed. The surface tension is assumed to vary linearly with temperature. Physical aspects of magnetohydrodynamics and thermal radiation are also accounted. The governing problem is modelled under boundary layer approximations for fluid phase and dust particle phase and then Runge-Kutta-Fehlberg method based numeric solutions are established. The momentum and heat transport mechanisms are focused on the result of distinct governing parameters. The Nusselt number is also calculated. It is established that the rate of heat transfer can be enhanced by suspending dust particles in the base fluid. The temperature field of fluid phase and temperature of dust phase are quite reverse for thermal dust parameter. The radiative heat, viscous dissipation and Joule heating aspects are constructive for thermal fields of fluid and dust phases. The velocity of dusty Casson fluid dominates the velocity of dusty fluid while this trend is opposite in the case of temperature. Moreover qualitative behaviour of fluid phase and dust phase temperature/velocity are similar.

  13. Application of Phase Shifted, Laser Feedback Interferometry to Fluid Physics

    Science.gov (United States)

    Ovryn, Ben; Eppell, Steven J.; Andrews, James H.; Khaydarov, John

    1996-01-01

    We have combined the principles of phase-shifting interferometry (PSI) and laser-feedback interferometry (LFI) to produce a new instrument that can measure both optical path length (OPL) changes and discern sample reflectivity variations. In LFI, coherent feedback of the incident light either reflected directly from a surface or reflected after transmission through a region of interest will modulate the output intensity of the laser. LFI can yield a high signal-to-noise ratio even for low reflectivity samples. By combining PSI and LFI, we have produced a robust instrument, based upon a HeNe laser, with high dynamic range that can be used to measure either static (dc) or oscillatory changes along the optical path. As with other forms of interferometry, large changes in OPL require phase unwrapping. Conversely, small phase changes are limited by the fraction of a fringe that can be measured. We introduce the phase shifts with an electro-optic modulator (EOM) and use either the Carre or Hariharan algorithms to determine the phase and visibility. We have determined the accuracy and precision of our technique by measuring both the bending of a cantilevered piezoelectric bimorph and linear ramps to the EOM. Using PSI, sub-nanometer displacements can be measured. We have combined our interferometer with a commercial microscope and scanning piezoelectric stage and have measured the variation in OPL and visibility for drops of PDMS (silicone oil) on coated single crystal silicon. Our measurement of the static contact angle agrees with the value of 68 deg stated in the literature.

  14. Validation of model predictions of pore-scale fluid distributions during two-phase flow

    Science.gov (United States)

    Bultreys, Tom; Lin, Qingyang; Gao, Ying; Raeini, Ali Q.; AlRatrout, Ahmed; Bijeljic, Branko; Blunt, Martin J.

    2018-05-01

    Pore-scale two-phase flow modeling is an important technology to study a rock's relative permeability behavior. To investigate if these models are predictive, the calculated pore-scale fluid distributions which determine the relative permeability need to be validated. In this work, we introduce a methodology to quantitatively compare models to experimental fluid distributions in flow experiments visualized with microcomputed tomography. First, we analyzed five repeated drainage-imbibition experiments on a single sample. In these experiments, the exact fluid distributions were not fully repeatable on a pore-by-pore basis, while the global properties of the fluid distribution were. Then two fractional flow experiments were used to validate a quasistatic pore network model. The model correctly predicted the fluid present in more than 75% of pores and throats in drainage and imbibition. To quantify what this means for the relevant global properties of the fluid distribution, we compare the main flow paths and the connectivity across the different pore sizes in the modeled and experimental fluid distributions. These essential topology characteristics matched well for drainage simulations, but not for imbibition. This suggests that the pore-filling rules in the network model we used need to be improved to make reliable predictions of imbibition. The presented analysis illustrates the potential of our methodology to systematically and robustly test two-phase flow models to aid in model development and calibration.

  15. Measurement of average density and relative volumes in a dispersed two-phase fluid

    Science.gov (United States)

    Sreepada, Sastry R.; Rippel, Robert R.

    1992-01-01

    An apparatus and a method are disclosed for measuring the average density and relative volumes in an essentially transparent, dispersed two-phase fluid. A laser beam with a diameter no greater than 1% of the diameter of the bubbles, droplets, or particles of the dispersed phase is directed onto a diffraction grating. A single-order component of the diffracted beam is directed through the two-phase fluid and its refraction is measured. Preferably, the refracted beam exiting the fluid is incident upon a optical filter with linearly varing optical density and the intensity of the filtered beam is measured. The invention can be combined with other laser-based measurement systems, e.g., laser doppler anemometry.

  16. Long-wave equivalent viscoelastic solids for porous rocks saturated by two-phase fluids

    Science.gov (United States)

    Santos, J. E.; Savioli, G. B.

    2018-04-01

    Seismic waves traveling across fluid-saturated poroelastic materials with mesoscopic-scale heterogeneities induce fluid flow and Biot's slow waves generating energy loss and velocity dispersion. Using Biot's equations of motion to model these type of heterogeneities would require extremely fine meshes. We propose a numerical upscaling procedure to determine the complex and frequency dependent P-wave and shear moduli of an effective viscoelastic medium long-wave equivalent to a poroelastic solid saturated by a two-phase fluid. The two-phase fluid is defined in terms of capillary pressure and relative permeability flow functions. The P-wave and shear effective moduli are determined using harmonic compressibility and shear experiments applied on representative samples of the bulk material. Each experiment is associated with a boundary value problem that is solved using the finite element method. Since a poroelastic solid saturated by a two-phase fluid supports the existence of two slow waves, this upscaling procedure allows to analyze their effect on the mesoscopic-loss mechanism in hydrocarbon reservoir formations. Numerical results show that a two-phase Biot medium model predicts higher attenuation than classic Biot models.

  17. Phase-Shifting Liquid Crystal Interferometers for Microgravity Fluid Physics

    Science.gov (United States)

    Griffin, DeVon W.; Marshall, Keneth L.

    2002-01-01

    The initial focus of this project was to eliminate both of these problems in the Liquid Crystal Point-Diffraction Interferometer (LCPDI). Progress toward that goal will be described, along with the demonstration of a phase shifting Liquid Crystal Shearing Interferometer (LCSI) that was developed as part of this work. The latest LCPDI, other than a lens to focus the light from a test section onto a diffracting microsphere within the interferometer and a collimated laser for illumination, the pink region contained within the glass plates on the rod-mounted platform is the complete interferometer. The total width is approximately 1.5 inches with 0.25 inches on each side for bonding the electrical leads. It is 1 inch high and there are only four diffracting microspheres within the interferometer. As a result, it is very easy to align, achieving the first goal. The liquid crystal electro-optical response time is a function of layer thickness, with thinner devices switching faster due to a reduction in long-range viscoelastic forces between the LC molecules. The LCPDI has a liquid crystal layer thickness of 10 microns, which is controlled by plastic or glass microspheres embedded in epoxy 'pads' at the corners of the device. The diffracting spheres are composed of polystyrene/divinyl benzene polymer with an initial diameter of 15 microns. The spheres deform slightly when the interferometer is assembled to conform to the spacing produced by the microsphere-filled epoxy spacer pads. While the speed of this interferometer has not yet been tested, previous LCPDIs fabricated at the Laboratory for Laser Energetics switched at a rate of approximately 3.3 Hz, a factor of 10 slower than desired. We anticipate better performance when the speed of these interferometers is tested since they are approximately three times thinner. Phase shifting in these devices is a function of the AC voltage level applied to the liquid crystal. As the voltage increases, the dye in the liquid crystal

  18. Scaling of two-phase flow transients using reduced pressure system and simulant fluid

    International Nuclear Information System (INIS)

    Kocamustafaogullari, G.; Ishii, M.

    1987-01-01

    Scaling criteria for a natural circulation loop under single-phase flow conditions are derived. Based on these criteria, practical applications for designing a scaled-down model are considered. Particular emphasis is placed on scaling a test model at reduced pressure levels compared to a prototype and on fluid-to-fluid scaling. The large number of similarty groups which are to be matched between modell and prototype makes the design of a scale model a challenging tasks. The present study demonstrates a new approach to this clasical problen using two-phase flow scaling parameters. It indicates that a real time scaling is not a practical solution and a scaled-down model should have an accelerated (shortened) time scale. An important result is the proposed new scaling methodology for simulating pressure transients. It is obtained by considerung the changes of the fluid property groups which appear within the two-phase similarity parameters and the single-phase to two-phase flow transition prameters. Sample calculations are performed for modeling two-phase flow transients of a high pressure water system by a low-pressure water system or a Freon system. It is shown that modeling is possible for both cases for simulation pressure transients. However, simulation of phase change transitions is not possible by a reduced pressure water system without distortion in either power or time. (orig.)

  19. Formation of structural steady states in lamellar/sponge phase-separating fluids under shear flow

    Science.gov (United States)

    Panizza, P.; Courbin, L.; Cristobal, G.; Rouch, J.; Narayanan, T.

    2003-05-01

    We investigate the effect of shear flow on a lamellar-sponge phase-separating fluid when subjected to shear flow. We show the existence of two different steady states (droplets and ribbons structures) whose nature does not depend on the way to reach the two-phase unstable region of the phase diagram (temperature quench or stirring). The transition between ribbons and droplets is shear thickening and its nature strongly depends on what dynamical variable is imposed. If the stress is fixed, flow visualization shows the existence of shear bands at the transition, characteristic of coexistence in the cell between ribbons and droplets. In this shear-banding region, the viscosity oscillates. When the shear rate is fixed, no shear bands are observed. Instead, the transition exhibits a hysteretic behavior leading to a structural bi-stability of the phase-separating fluid under flow.

  20. Phenomena at the QCD phase transition in nonequilibrium chiral fluid dynamics (NχFD)

    Energy Technology Data Exchange (ETDEWEB)

    Nahrgang, Marlene [Duke University, Department of Physics, Durham, NC (United States); Herold, Christoph [Suranaree University of Technology, School of Physics, Nakhon Ratchasima (Thailand)

    2016-08-15

    Heavy-ion collisions performed in the beam energy range accessible by the NICA collider facility are expected to produce systems of extreme net-baryon densities and can thus reach yet unexplored regions of the QCD phase diagram. Here, one expects the phase transition between the plasma of deconfined quarks and gluons and the hadronic matter to be of first order. A discovery of the first-order phase transition would as well prove the existence of the QCD critical point, a landmark in the phase diagram. In order to understand possible signals of the first-order phase transition in heavy-ion collision experiments it is very important to develop dynamical models of the phase transition. Here, we discuss the opportunities of studying dynamical effects at the QCD first-order phase transition within our model of nonequilibrium chiral fluid dynamics. (orig.)

  1. Study of Two-Phase Heat Transfer in Nano-fluids for Nuclear Applications

    International Nuclear Information System (INIS)

    Kim, S.J.; Truong, B.; Buongiorno, J.; Hu, L.W.; Bang, I.C.

    2006-01-01

    Nano-fluids are engineered colloidal suspensions of nano-particles in a base fluid. We are investigating the two-phase heat transfer behavior of water-based nano-fluids, to evaluate their potential use in nuclear applications, including the PWR primary coolant and PWR and BWR safety systems. A simple pool boiling wire experiment shows that a significant increase in Critical Heat Flux (CHF) can be achieved at modest nano-particle concentrations. For example, the CHF increases by 50% in nano-fluids with alumina nano-particles at 0.001%v concentration. The CHF enhancement appears to correlate with the presence of a layer of nano-particles that builds up on the heated surface during nucleate boiling. A review of the prevalent Departure from Nucleate Boiling (DNB) theories suggests that an alteration of the nucleation site density (brought about by the nano-particle layer) could plausibly explain the CHF enhancement. (authors)

  2. Phase diagram and transport properties for hydrogen-helium fluid planets

    International Nuclear Information System (INIS)

    Stevenson, D.J.; Salpeter, E.E.

    1977-01-01

    Hydrogen and helium are the major constituents of Jupiter and Saturn, and phase transitions can have important effects on the planetary structure. In this paper, the relevant phase diagrams and microscopic transport properties are analyzed in detail. The following paper (Paper II) applies these results to the evolution and present dynamic structure of the Jovian planets.Pure hydrogen is first discussed, especially the nature of the molecular-metallic transition and the melting curves for the two phases. It is concluded that at the temperatures and pressures of interest (Tapprox. =10 4 K, Papprox. =1--10 Mbar), both phases are fluid, but the transition between them might nevertheless be first-order. The insulator-metal transition in helium occurs at a much higher pressure (approx.70 Mbars) and is not of interest.The phase diagrams for both molecular and metallic hydrogen-helium mixtures are discussed. In the metallic mixture, calculations indicate a miscibility gap for T9 or approx. =10 4 K. Immiscibility in the molecular mixture is more difficult to predict but almost certainly occurs at much lower temperatures. A fluid-state model is constructed which predicts the likely topology of the three-dimensional phase diagram. The greater solubility of helium in the molecular phase leads to the prediction that the He/H mass ratio is typically twice as large in the molecular phase as in the coexisting metallic phase. Under these circumstances a ''density inversion'' is possible in which the molecular phase becomes more dense than the metallic phase.The partitioning of minor constituents is also considered: The deuterium/hydrogen mass ratio is essentially the same for all coexisting hydrogen-helium phases, at least for T> or approx. =5000 K. The partitioning of H 2 O, CH 4 , and NH 3 probably favors the molecular (or helium-rich) phase. Substances with high conduction electron density (e.g., Al) may partition into the metallic phase

  3. Phase Behaviors of Reservoir Fluids with Capillary Eff ect Using Particle Swarm Optimization

    KAUST Repository

    Ma, Zhiwei

    2013-05-06

    The study of phase behavior is important for the oil and gas industry. Many approaches have been proposed and developed for phase behavior calculation. In this thesis, an alternative method is introduced to study the phase behavior by means of minimization of Helmholtz free energy. For a system at fixed volume, constant temperature and constant number of moles, the Helmholtz free energy reaches minimum at the equilibrium state. Based on this theory, a stochastic method called Particle Swarm Optimization (PSO) algorithm, is implemented to compute the phase diagrams for several pure component and mixture systems. After comparing with experimental and the classical PT-ash calculation, we found the phase diagrams obtained by minimization of the Helmholtz Free Energy approach match the experimental and theoretical diagrams very well. Capillary effect is also considered in this thesis because it has a significant influence on the phase behavior of reservoir fluids. In this part, we focus on computing the phase envelopes, which consists of bubble and dew point lines. Both fixed and calculated capillary pressure from the Young-Laplace equation cases are introduced to study their effects on phase envelopes. We found that the existence of capillary pressure will change the phase envelopes. Positive capillary pressure reduces the dew point and bubble point temperatures under the same pressure condition, while the negative capillary pressure increases the dew point and bubble point temperatures. In addition, the change of contact angle and pore radius will affect the phase envelope. The effect of the pore radius on the phase envelope is insignificant when the radius is very large. These results may become reference for future research and study. Keywords: Phase Behavior; Particle Swarm Optimization; Capillary Pressure; Reservoir Fluids; Phase Equilibrium; Phase Envelope.

  4. Phase Behaviors of Reservoir Fluids with Capillary Eff ect Using Particle Swarm Optimization

    KAUST Repository

    Ma, Zhiwei

    2013-01-01

    The study of phase behavior is important for the oil and gas industry. Many approaches have been proposed and developed for phase behavior calculation. In this thesis, an alternative method is introduced to study the phase behavior by means of minimization of Helmholtz free energy. For a system at fixed volume, constant temperature and constant number of moles, the Helmholtz free energy reaches minimum at the equilibrium state. Based on this theory, a stochastic method called Particle Swarm Optimization (PSO) algorithm, is implemented to compute the phase diagrams for several pure component and mixture systems. After comparing with experimental and the classical PT-ash calculation, we found the phase diagrams obtained by minimization of the Helmholtz Free Energy approach match the experimental and theoretical diagrams very well. Capillary effect is also considered in this thesis because it has a significant influence on the phase behavior of reservoir fluids. In this part, we focus on computing the phase envelopes, which consists of bubble and dew point lines. Both fixed and calculated capillary pressure from the Young-Laplace equation cases are introduced to study their effects on phase envelopes. We found that the existence of capillary pressure will change the phase envelopes. Positive capillary pressure reduces the dew point and bubble point temperatures under the same pressure condition, while the negative capillary pressure increases the dew point and bubble point temperatures. In addition, the change of contact angle and pore radius will affect the phase envelope. The effect of the pore radius on the phase envelope is insignificant when the radius is very large. These results may become reference for future research and study. Keywords: Phase Behavior; Particle Swarm Optimization; Capillary Pressure; Reservoir Fluids; Phase Equilibrium; Phase Envelope.

  5. The constitutive distributed parameter model of multicomponent chemical processes in gas, fluid and solid phase

    International Nuclear Information System (INIS)

    Niemiec, W.

    1985-01-01

    In the literature of distributed parameter modelling of real processes is not considered the class of multicomponent chemical processes in gas, fluid and solid phase. The aim of paper is constitutive distributed parameter physicochemical model, constructed on kinetics and phenomenal analysis of multicomponent chemical processes in gas, fluid and solid phase. The mass, energy and momentum aspects of these multicomponent chemical reactions and adequate phenomena are utilized in balance operations, by conditions of: constitutive invariance for continuous media with space and time memories, reciprocity principle for isotropic and anisotropic nonhomogeneous media with space and time memories, application of definitions of following derivative and equation of continuity, to the construction of systems of partial differential constitutive state equations, in the following derivative forms for gas, fluid and solid phase. Couched in this way all physicochemical conditions of multicomponent chemical processes in gas, fluid and solid phase are new form of constitutive distributed parameter model for automatics and its systems of equations are new form of systems of partial differential constitutive state equations in sense of phenomenal distributed parameter control

  6. Computational fluid dynamics simulations of blood flow regularized by 3D phase contrast MRI

    DEFF Research Database (Denmark)

    Rispoli, Vinicius C; Nielsen, Jon; Nayak, Krishna S

    2015-01-01

    BACKGROUND: Phase contrast magnetic resonance imaging (PC-MRI) is used clinically for quantitative assessment of cardiovascular flow and function, as it is capable of providing directly-measured 3D velocity maps. Alternatively, vascular flow can be estimated from model-based computation fluid dyn...

  7. Mathematical well-posedness of a two-fluid equations for bubbly two-phase flows

    International Nuclear Information System (INIS)

    Okawa, Tomio; Kataoka, Isao

    2000-01-01

    It is widely known that two-fluid equations used in most engineering applications do not satisfy the necessary condition for being mathematical well-posed as initial-value problems. In the case of stratified two-phase flows, several researchers have revealed that differential models satisfying the necessary condition are to be derived if the pressure difference between the phases is related to the spatial gradient of the void fraction through the effects of gravity or surface tension. While, in the case of dispersed two-phase flows, no physically reasonable method to derive mathematically well-posed two-fluid model has been proposed. In the present study, particularly focusing on the effect of interfacial pressure terms, we derived the mathematically closed form of the volume-averaged two-fluid model for bubbly two-phase flows. As a result of characteristic analyses, it was shown that the proposed two-fluid equations satisfy the necessary condition of mathematical well-posedness if the void fraction is sufficiently small. (author)

  8. RELAP5 two-phase fluid model and numerical scheme for economic LWR system simulation

    International Nuclear Information System (INIS)

    Ransom, V.H.; Wagner, R.J.; Trapp, J.A.

    1981-01-01

    The RELAP5 two-phase fluid model and the associated numerical scheme are summarized. The experience accrued in development of a fast running light water reactor system transient analysis code is reviewed and example of the code application are given

  9. Ultrasound Microbubble Treatment Enhances Clathrin-Mediated Endocytosis and Fluid-Phase Uptake through Distinct Mechanisms.

    Directory of Open Access Journals (Sweden)

    Farnaz Fekri

    Full Text Available Drug delivery to tumors is limited by several factors, including drug permeability of the target cell plasma membrane. Ultrasound in combination with microbubbles (USMB is a promising strategy to overcome these limitations. USMB treatment elicits enhanced cellular uptake of materials such as drugs, in part as a result of sheer stress and formation of transient membrane pores. Pores formed upon USMB treatment are rapidly resealed, suggesting that other processes such as enhanced endocytosis may contribute to the enhanced material uptake by cells upon USMB treatment. How USMB regulates endocytic processes remains incompletely understood. Cells constitutively utilize several distinct mechanisms of endocytosis, including clathrin-mediated endocytosis (CME for the internalization of receptor-bound macromolecules such as Transferrin Receptor (TfR, and distinct mechanism(s that mediate the majority of fluid-phase endocytosis. Tracking the abundance of TfR on the cell surface and the internalization of its ligand transferrin revealed that USMB acutely enhances the rate of CME. Total internal reflection fluorescence microscopy experiments revealed that USMB treatment altered the assembly of clathrin-coated pits, the basic structural units of CME. In addition, the rate of fluid-phase endocytosis was enhanced, but with delayed onset upon USMB treatment relative to the enhancement of CME, suggesting that the two processes are distinctly regulated by USMB. Indeed, vacuolin-1 or desipramine treatment prevented the enhancement of CME but not of fluid phase endocytosis upon USMB, suggesting that lysosome exocytosis and acid sphingomyelinase, respectively, are required for the regulation of CME but not fluid phase endocytosis upon USMB treatment. These results indicate that USMB enhances both CME and fluid phase endocytosis through distinct signaling mechanisms, and suggest that strategies for potentiating the enhancement of endocytosis upon USMB treatment may

  10. A fluid biopsy as investigating technology for the fluid phase of solid tumors

    Science.gov (United States)

    Kuhn, Peter; Bethel, Kelly

    2012-02-01

    , which has shown predictive utility in several cancer types—the blurry outlines of things to come began to coalesce. The field of CTC research is in its adolescence; enumeration and characterization research effort is methodologically varied, vigorously individuated and rich in innovation. The high definition CTC (HD-CTC) assay described herein and applied to several currently relevant research questions about cancer spread represents a new measure of an internal biologic process that will hopefully lead to great advancements in cancer medicine. First, the paper entitled 'Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers' by Marrinucci et al, represents the initial technical and clinical validation of an enrichment-free assay and demonstrates our ability to identify significant numbers of HD-CTCs in a majority of patients with prostate, breast and pancreatic cancers. It demonstrates very high rates of detection (>50%) in breast, prostate and pancreatic cancer patients with no CTCs found in normal control subjects. The assay detects significantly higher numbers of CTCs than the FDA-approved Cellsearch® assay and shows the presence of clusters of CTCs in many patients. The nature of the clusters is further evaluated in 'Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors' by Cho et al, wherein CTC aggregates are identified in 43% of 86 patient samples. The fraction of CTC aggregation was investigated in blood draws from 24 breast, 14 non-small cell lung (NSCLC), 18 pancreatic, 15 prostate stage IV cancer patients and 15 normal blood donors (NBD). Cells contained in CTC aggregates had less area and length, on average, than single CTCs. The nuclear to cytoplasmic (N/C) ratio between single CTCs and CTC aggregates was similar. To assist with translating into patients the substantial cell biology work done using cell line cells instead of human tumor tissue, the paper entitled 'Cytometric

  11. The mechanism of reequilibration of solids in the presence of a fluid phase

    International Nuclear Information System (INIS)

    Putnis, Andrew; Putnis, Christine V.

    2007-01-01

    The preservation of morphology (pseudomorphism) and crystal structure during the transformation of one solid phase to another is regularly used as a criterion for a solid-state mechanism, even when there is a fluid phase present. However, a coupled dissolution-reprecipitation mechanism also preserves the morphology and transfers crystallographic information from parent to product by epitaxial nucleation. The generation of porosity in the product phase is a necessary condition for such a mechanism as it allows fluid to maintain contact with a reaction interface which moves through the parent phase from the original surface. We propose that interface-coupled dissolution-reprecipitation is a general mechanism for reequilibration of solids in the presence of a fluid phase. - Graphical abstract: A single crystal of KBr is transformed to a porous single crystal of KCl by immersion in saturated KCl solution. The image shows partial transformation of a crystal of KBr (core) to KCl (porous, milky rim) by an interface coupled dissolution-reprecipitation mechanism. The external dimensions and crystallographic orientation of the original crystal are preserved, while a reaction interface moves through the crystal

  12. Direct numerical simulations of fluid flow, heat transfer and phase changes

    Science.gov (United States)

    Juric, D.; Tryggvason, G.; Han, J.

    1997-01-01

    Direct numerical simulations of fluid flow, heat transfer, and phase changes are presented. The simulations are made possible by a recently developed finite difference/front tracking method based on the one-field formulation of the governing equations where a single set of conservation equations is written for all the phases involved. The conservation equations are solved on a fixed rectangular grid, but the phase boundaries are kept sharp by tracking them explicitly by a moving grid of lower dimension. The method is discussed and applications to boiling heat transfer and the solidification of drops colliding with a wall are shown.

  13. Dimple coalescence and liquid droplets distributions during phase separation in a pure fluid under microgravity.

    Science.gov (United States)

    Oprisan, Ana; Oprisan, Sorinel A; Hegseth, John J; Garrabos, Yves; Lecoutre-Chabot, Carole; Beysens, Daniel

    2014-09-01

    Phase separation has important implications for the mechanical, thermal, and electrical properties of materials. Weightless conditions prevent buoyancy and sedimentation from affecting the dynamics of phase separation and the morphology of the domains. In our experiments, sulfur hexafluoride (SF6) was initially heated about 1K above its critical temperature under microgravity conditions and then repeatedly quenched using temperature steps, the last one being of 3.6 mK, until it crossed its critical temperature and phase-separated into gas and liquid domains. Both full view (macroscopic) and microscopic view images of the sample cell unit were analyzed to determine the changes in the distribution of liquid droplet diameters during phase separation. Previously, dimple coalescences were only observed in density-matched binary liquid mixture near its critical point of miscibility. Here we present experimental evidences in support of dimple coalescence between phase-separated liquid droplets in pure, supercritical, fluids under microgravity conditions. Although both liquid mixtures and pure fluids belong to the same universality class, both the mass transport mechanisms and their thermophysical properties are significantly different. In supercritical pure fluids the transport of heat and mass are strongly coupled by the enthalpy of condensation, whereas in liquid mixtures mass transport processes are purely diffusive. The viscosity is also much smaller in pure fluids than in liquid mixtures. For these reasons, there are large differences in the fluctuation relaxation time and hydrodynamics flows that prompted this experimental investigation. We found that the number of droplets increases rapidly during the intermediate stage of phase separation. We also found that above a cutoff diameter of about 100 microns the size distribution of droplets follows a power law with an exponent close to -2, as predicted from phenomenological considerations.

  14. Two-phase flow modeling for low concentration spherical particle motion through a Newtonian fluid

    CSIR Research Space (South Africa)

    Smit GJF

    2010-11-01

    Full Text Available the necessity to model the discrete nature of sep- cite this article in press as: G.J.F. Smit et al., Two-phase flow modeling for low concentration spherical particle motion through a ian fluid, Appl. Math. Comput. (2010), doi:10.1016/j.amc.2010.07.055 2... and Ribberin large-scale and long term morphologica Please cite this article in press as: G.J.F. Smit Newtonian fluid, Appl. Math. Comput. (2010), � 2010 Elsevier Inc. All rights reserved. modeling of multiphase flow has increasingly become the subject...

  15. The investigation of a two-layer fluid soliton pair using phase plane analysis

    International Nuclear Information System (INIS)

    Momeni, M.; Moslehi-Fard, M.; Alinejad, H.; Mahmoodi, J.

    2004-01-01

    Nonlinear long waves theory in a two-layer fluid system has been studied. The dynamical equations according to the normalized heights in first order are obtained using the reductive perturbation method and the equations of shallow water in each fluid and taking boundary conditions appropriate into account. Conserve energy form by definition a independent variable is found. By definition a Lyapunov function, the condition for stability are shown. A new technique was used to prove stability as well as existence of soliton pair using phase plane analysis. (author)

  16. Equilibres de phases dans les systèmes fluides petroliers-eau Phase Equilibria in Oil-Water Systems

    Directory of Open Access Journals (Sweden)

    Peneloux A.

    2006-11-01

    Full Text Available Nous présentons quelques résultats obtenus à partir du logiciel FHYD qui permet le traitement des mélanges eau-fluides pétroliers, avec la détermination de la nature des phases (huile-gaz-eau-hydrate thermodynamiquement stables dans des conditions données de température et de pression, ainsi que de la quantité, de la composition de ces différentes phases et de leurs propriétés. Ce logiciel permet le tracé automatique des diagrammes de phases et nous présentons des exemples, depuis les systèmes binaires (eau-éthane, ternaires (eau-méthane-propane jusqu'aux fluides les plus complexes. La présence de sels (chlorure de sodium dissous est envisagée, ainsi que le calcul des conditions de dépôt du sel solide. Des exemples de problèmes pétroliers sont cités (gaz de séparateur saturé en eau, huile saturée en eau dans les conditions de gisement, huile en présence d'eau salée. Les estimations sur les quantités d'hydrate formées et leurs compositions sont comparées à des données expérimentales et aux résultats obtenus par d'autres logiciels. Le programme FHYD pourrait permettre une représentation plus réaliste de l'évolution des fluides pétroliers et des propriétés de transport de leurs différentes phases dans les modèles de simulation des conduites polyphasiques. This article presents a selection of results obtained with the FHYD program. This software allows simulation of mixtures composed of petroleum fluids and water, with determination of the nature of thermodynamically stable phases (oil-gas-water-hydrate under given conditions of temperature and pressure, along with the quantity, composition and properties of these different phases. Additionally, the program can automatically produce phase diagrams. Several examples of these have been included here, ranging from binary systems (water-ethane and ternary systems (water-methane-propane to the most complex petroleum fluids. The presence of dissolved salts

  17. Numerical modeling of two-phase binary fluid mixing using mixed finite elements

    KAUST Repository

    Sun, Shuyu

    2012-07-27

    Diffusion coefficients of dense gases in liquids can be measured by considering two-phase binary nonequilibrium fluid mixing in a closed cell with a fixed volume. This process is based on convection and diffusion in each phase. Numerical simulation of the mixing often requires accurate algorithms. In this paper, we design two efficient numerical methods for simulating the mixing of two-phase binary fluids in one-dimensional, highly permeable media. Mathematical model for isothermal compositional two-phase flow in porous media is established based on Darcy\\'s law, material balance, local thermodynamic equilibrium for the phases, and diffusion across the phases. The time-lag and operator-splitting techniques are used to decompose each convection-diffusion equation into two steps: diffusion step and convection step. The Mixed finite element (MFE) method is used for diffusion equation because it can achieve a high-order and stable approximation of both the scalar variable and the diffusive fluxes across grid-cell interfaces. We employ the characteristic finite element method with moving mesh to track the liquid-gas interface. Based on the above schemes, we propose two methods: single-domain and two-domain methods. The main difference between two methods is that the two-domain method utilizes the assumption of sharp interface between two fluid phases, while the single-domain method allows fractional saturation level. Two-domain method treats the gas domain and the liquid domain separately. Because liquid-gas interface moves with time, the two-domain method needs work with a moving mesh. On the other hand, the single-domain method allows the use of a fixed mesh. We derive the formulas to compute the diffusive flux for MFE in both methods. The single-domain method is extended to multiple dimensions. Numerical results indicate that both methods can accurately describe the evolution of the pressure and liquid level. © 2012 Springer Science+Business Media B.V.

  18. Simulation of horizontal pipe two-phase slug flows using the two-fluid model

    Energy Technology Data Exchange (ETDEWEB)

    Ortega Malca, Arturo J. [Pontificia Univ. Catolica do Rio de Janeiro, RJ (Brazil). Dept. de Engenharia Mecanica. Nucleo de Simulacao Termohidraulica de Dutos (SIMDUT); Nieckele, Angela O. [Pontificia Univ. Catolica do Rio de Janeiro, RJ (Brazil). Dept. de Engenharia Mecanica

    2005-07-01

    Slug flow occurs in many engineering applications, mainly in the transport of hydrocarbon fluids in pipelines. The intermittency of slug flow causes severe unsteady loading on the pipelines carrying the fluids, which gives rise to design problems. Therefore, it is important to be able to predict the onset and development of slug flow as well as slug characteristics. The present work consists in the simulation of two-phase flow in slug pattern through horizontal pipes using the two-fluid model in its transient and one-dimensional form. The advantage of this model is that the flow field is allowed to develop naturally from a given initial conditions as part of the transient calculation; the slug evolves automatically as a product of the computed flow development. Simulations are then carried out for a large number of flow conditions that lead a slug flow. (author)

  19. Phase-resolved fluid dynamic forces of a flapping foil energy harvester based on PIV measurements

    Science.gov (United States)

    Liburdy, James

    2017-11-01

    Two-dimensional particle image velocimetry measurements are performed in a wind tunnel to evaluate the spatial and temporal fluid dynamic forces acting on a flapping foil operating in the energy harvesting regime. Experiments are conducted at reduced frequencies (k = fc/U) of 0.05 - 0.2, pitching angle of, and heaving amplitude of A / c = 0.6. The phase-averaged pressure field is obtained by integrating the pressure Poisson equation. Fluid dynamic forces are then obtained through the integral momentum equation. Results are compared with a simple force model based on the concept of flow impulse. These results help to show the detailed force distributions, their transient nature and aide in understanding the impact of the fluid flow structures that contribute to the power production.

  20. General model of phospholipid bilayers in fluid phase within the single chain mean field theory

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Yachong; Baulin, Vladimir A. [Departament d’Enginyeria Química, Universitat Rovira i Virgili, Av. dels Paisos Catalans 26, 43007 Tarragona (Spain); Pogodin, Sergey [Institute of Chemical Research of Catalonia, ICIQ, Av. Paisos Catalans 16, 43007 Tarragona (Spain)

    2014-05-07

    Coarse-grained model for saturated phospholipids: 1,2-didecanoyl-sn-glycero-3-phosphocholine (DCPC), 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and unsaturated phospholipids: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1,2- dioleoyl-sn-glycero-3-phosphocholine (DOPC) is introduced within the single chain mean field theory. A single set of parameters adjusted for DMPC bilayers gives an adequate description of equilibrium and mechanical properties of a range of saturated lipid molecules that differ only in length of their hydrophobic tails and unsaturated (POPC, DOPC) phospholipids which have double bonds in the tails. A double bond is modeled with a fixed angle of 120°, while the rest of the parameters are kept the same as saturated lipids. The thickness of the bilayer and its hydrophobic core, the compressibility, and the equilibrium area per lipid correspond to experimentally measured values for each lipid, changing linearly with the length of the tail. The model for unsaturated phospholipids also fetches main thermodynamical properties of the bilayers. This model is used for an accurate estimation of the free energies of the compressed or stretched bilayers in stacks or multilayers and gives reasonable estimates for free energies. The proposed model may further be used for studies of mixtures of lipids, small molecule inclusions, interactions of bilayers with embedded proteins.

  1. A Two-Phase Solid/Fluid Model for Dense Granular Flows Including Dilatancy Effects

    Science.gov (United States)

    Mangeney, Anne; Bouchut, Francois; Fernandez-Nieto, Enrique; Narbona-Reina, Gladys

    2015-04-01

    We propose a thin layer depth-averaged two-phase model to describe solid-fluid mixtures such as debris flows. It describes the velocity of the two phases, the compression/dilatation of the granular media and its interaction with the pore fluid pressure, that itself modifies the friction within the granular phase (Iverson et al., 2010). The model is derived from a 3D two-phase model proposed by Jackson (2000) based on the 4 equations of mass and momentum conservation within the two phases. This system has 5 unknowns: the solid and fluid velocities, the solid and fluid pressures and the solid volume fraction. As a result, an additional equation inside the mixture is necessary to close the system. Surprisingly, this issue is inadequately accounted for in the models that have been developed on the basis of Jackson's work (Bouchut et al., 2014). In particular, Pitman and Le replaced this closure simply by imposing an extra boundary condition at the surface of the flow. When making a shallow expansion, this condition can be considered as a closure condition. However, the corresponding model cannot account for a dissipative energy balance. We propose here an approach to correctly deal with the thermodynamics of Jackson's equations. We close the mixture equations by a weak compressibility relation involving a critical density, or equivalently a critical pressure. Moreover, we relax one boundary condition, making it possible for the fluid to escape the granular media when compression of the granular mass occurs. Furthermore, we introduce second order terms in the equations making it possible to describe the evolution of the pore fluid pressure in response to the compression/dilatation of the granular mass without prescribing an extra ad-hoc equation for the pore pressure. We prove that the energy balance associated with this Jackson closure is dissipative, as well as its thin layer associated model. We present several numerical tests for the 1D case that are compared to the

  2. Immiscibility of Fluid Phases at Magmatic-hydrothermal Transition: Formation of Various PGE-sulfide Mineralization for Layered Basic Intrusions

    Science.gov (United States)

    Zhitova, L.; Borisenko, A.; Morgunov, K.; Zhukova, I.

    2007-12-01

    Fluid inclusions in quartz of the Merensky Reef (Bushveld Complex, South Africa) and the Chineisky Pluton (Transbaikal Region, Russia) were studied using cryometry, microthermometry, Raman-spectroscopy, LA ICP- MS, scanning electronic microscopy, gas-chromatography and isotopic methods. This allowed us to document some examples of fluid phase separation resulting in formation of different types of PGE-sulfide mineralization for layered basic intrusions. The results obtained show at least three generations of fluid separated from boiling residual alumosilicate intercumulus liquid of the Merensky Reef. The earliest fluid phase composed of homogenous high-dense methane and nitrogen gas mixture was identified in primary gas and co-existing anomalous fluid inclusions from symplectitic quartz. The next generation, heterophase fluid, composed of brines containing a free low-dense (mostly of carbon dioxide) gas phase, was observed in primary multiphase and coexisting gas-rich inclusions of miarolitic quartz crystals. The latest generation was also a heterophase fluid (low salinity water-salt solution and free low-dense methane gas phase) found in primary water-salt and syngenetic gas inclusions from peripheral zones of miarolitic quartz crystals. For the Chineisky Pluton reduced endocontact magmatogene fluids changed to oxidized low salinity hydrothermal fluids in exocontact zone. This resulted in formation of sulfide-PGE enrichment marginal zones of intrusion. The results obtained give us a possibility to suggest that: 1) Fluid phase separation is a typical feature of magmatogene fluids for layered basic intrusions. 2) Reduced fluids can extract and transport substantial PGE and sulfide concentrations. 3) Oxidation of reduced fluids is one of the most important geochemical barriers causing abundant PGE minerals and sulfides precipitation. This in turn results in both formation of PGE reefs or enriched contact zones of layered basic intrusions. This work was supported by

  3. Ex vivo characterization of pathologic fluids with quantitative phase-contrast computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Richter, Vivien, E-mail: vivien.richter@med.uni-tuebingen.de [Department of Diagnostic and Interventional Radiology, Eberhard Karls Universität Tübingen, Hoppe-Seyler-Weg 3, 72076 Tuebingen (Germany); Willner, Marian S., E-mail: marian.willner@ph.tum.de [Department of Physics & Institute of Medical Engineering, Technische Universität München, James-Franck-Strasse 1, 85748 Garching (Germany); Henningsen, John, E-mail: john.henningsen@tum.de [Department of Physics & Institute of Medical Engineering, Technische Universität München, James-Franck-Strasse 1, 85748 Garching (Germany); Birnbacher, Lorenz, E-mail: lorenz.birnbacher@ph.tum.de [Department of Physics & Institute of Medical Engineering, Technische Universität München, James-Franck-Strasse 1, 85748 Garching (Germany); Marschner, Mathias, E-mail: mathias.marschner@ph.tum.de [Department of Physics & Institute of Medical Engineering, Technische Universität München, James-Franck-Strasse 1, 85748 Garching (Germany); Herzen, Julia, E-mail: julia.herzen@ph.tum.de [Department of Physics & Institute of Medical Engineering, Technische Universität München, James-Franck-Strasse 1, 85748 Garching (Germany); Kimm, Melanie A., E-mail: melanie.kimm@tum.de [Department of Diagnostic and Interventional Radiology, Technische Universität München, Ismaninger Str. 22, 81675 Munich (Germany); and others

    2017-01-15

    Purpose: X-ray phase-contrast imaging (PCI) provides additional information beyond absorption characteristics by detecting the phase shift of the X-ray beam passing through material. The grating-based system works with standard polychromatic X-ray sources, promising a possible clinical implementation. PCI has been shown to provide additional information in soft-tissue samples. The aim of this study was to determine if ex vivo quantitative phase-contrast computed tomography (PCCT) may differentiate between pathologic fluid collections. Materials and methods: PCCT was performed with the grating interferometry method. A protein serial dilution, human blood samples and 17 clinical samples of pathologic fluid retentions were imaged and correlated with clinical chemistry measurements. Conventional and phase-contrast tomography images were reconstructed. Phase-contrast Hounsfield Units (HUp) were used for quantitative analysis analogously to conventional HU. The imaging was analyzed using overall means, ROI values as well as whole-volume-histograms and vertical gradients. Contrast to noise ratios were calculated between different probes and between imaging methods. Results: HUp showed a very good linear correlation with protein concentration in vitro. In clinical samples, HUp correlated rather well with cell count and triglyceride content. PCI was better than absorption imaging at differentiating protein concentrations in the protein samples as well as at differentiating blood plasma from cellular components. PCI also allowed for differentiation of watery samples (such as lymphoceles) from pus. Conclusion: Phase-contrast computed tomography is a promising tool for the differentiation of pathologic fluids that appear homogenous with conventional attenuation imaging.

  4. US-UK Phase 3 Task 1 Oxidation in Supercritical Fluids

    Energy Technology Data Exchange (ETDEWEB)

    Holcomb, Gordon R. [National Energy Technology Lab. (NETL), Albany, OR (United States)

    2017-03-20

    A presentation of the US-UK Phase 3 Task 1 Oxidation in Supercritical Fluids. Includes slides on Supercritical Steam, sCO2 Power Cycles – Indirect, sCO2 Power Cycles – Direct, Experimental Exposures, Alloys, Why Si, Results—Ni-xCr Alloys (5-24Cr), Fatigue Crack Growth$-$Experiment, and Alloys and Samples, Fatigue Crack Growth—Results (H282).

  5. Lattice Boltzmann simulations of liquid crystalline fluids: active gels and blue phases

    OpenAIRE

    Cates, M. E.; Henrich, O.; Marenduzzo, D.; Stratford, K.

    2010-01-01

    Lattice Boltzmann simulations have become a method of choice to solve the hydrodynamic equations of motion of a number of complex fluids. Here we review some recent applications of lattice Boltzmann to study the hydrodynamics of liquid crystalline materials. In particular, we focus on the study of (a) the exotic blue phases of cholesteric liquid crystals, and (b) active gels - a model system for actin plus myosin solutions or bacterial suspensions. In both cases lattice Boltzmann studies have...

  6. Phase Envelope Calculations for Reservoir Fluids in the Presence of Capillary Pressure

    DEFF Research Database (Denmark)

    Lemus, Diego; Yan, Wei; Michelsen, Michael L.

    2015-01-01

    the bubble and dew point curves but also other quality lines with vapor fractions between 0 and 1. The algorithm has been used to calculate the phase envelopes of binary, multicomponent and reservoir fluid systems for pore radius from 10 to 50 nm. The presence of capillary pressure changes the saturation...... pressures in the whole phase envelope except at the critical point. The bubble point curve shows a negative change while the dew point curve shows positive and negative changes in the upper dew point branch and the lower dew point branch, respectively. In particular, the cricondentherm is also shifted...

  7. Simulating the phosphorus fluid-liquid phase transition up to the critical point

    International Nuclear Information System (INIS)

    Ghiringhelli, Luca M; Meijer, Evert Jan

    2007-01-01

    We report a Car-Parrinello molecular dynamics study of the temperature dependence of the fluid-liquid phase transition in phosphorous, involving the transformation of a molecular fluid phase into a network-like phase. We employed density-functional theory (DFT) with a gradient-corrected functional (B-LYP) to describe the electronic structure and interatomic interactions and performed simulations in a constant pressure ensemble. We spanned a temperature interval ranging from 2500 to 3500 K. With increasing temperature, we found that the structural conversion from the molecular P 4 fluid into the network liquid occurs at decreasing pressures, consistent with experimental observations. At lower temperatures the transition is characterized by a sudden increase of density in the sample. The magnitude of the density change decreases with increasing temperature and vanishes at 3500 K. In the temperature range 3100-3500 K we found signals of near- and super-criticality. We identified local structural changes that serve as seeds triggering the overall structural transition

  8. Evaluation of the truncated perturbed chain-polar statistical associating fluid theory for complex mixture fluid phase equilibria

    DEFF Research Database (Denmark)

    Karakatsani, Eirini; Kontogeorgis, Georgios; Economou, Ioannis

    2006-01-01

    Perturbed chain-statistical associating fluid theory (PC-SAFT) was extended rigorously to polar fluids based on the theory of Stell and co-workers [Mol. Phys. 1977, 33, 987]. The new PC-PSAFT was simplified to truncated PC-PSAFT (tPC-PSAFT) so that it can be practical for real polar fluid...

  9. Prediction of transport phenomena in near and far field: interaction solid phase/fluid phase

    International Nuclear Information System (INIS)

    Mingarro, E.

    1995-01-01

    The prediction of transport phenomena in near and far field is presented in the present report. The study begins with the analysis of solid phases stability: solubility of storage waste: UO 2 and solubility of radionuclides the redox and sorption-desorption conditions are the last aspects studied to predict the transport phenomena

  10. A Coarse-Grained Molecular Dynamics Study of DLPC, DMPC, DPPC, and DSPC Mixtures in Aqueous Solution

    Directory of Open Access Journals (Sweden)

    Roghayeh Abedi Karjiban

    2013-01-01

    Full Text Available The structural and dynamics properties of the bilayer comprising 128 molecules of dipalmitoylphosphatidylcholine (DPPC, dilauroylphosphatidylcholine (DLPC, dimyristoylphosphatidylcholine (DMPC, and distearoylphosphatidylcholine (DSPC in water were investigated using a coarse-grained molecular dynamics (CG-MD simulation technique. The model mixture system was simulated at 298 K under semi-isotropic pressure conditions. The aggregation was initiated from the random configurations followed by the formation of a bilayer over a period of 500 ns. The calculated values of the area per lipid, thickness, and lateral diffusion for the mixed model were different from when a single lipid was used. Our results confirmed that the chain length of the lipid molecules strongly affects the phospholipid bilayer’s physical properties.

  11. Seismoelectric couplings in a poroelastic material containing two immiscible fluid phases

    Science.gov (United States)

    Jardani, A.; Revil, A.

    2015-08-01

    A new approach of seismoelectric imaging has been recently proposed to detect saturation fronts in which seismic waves are focused in the subsurface to scan its heterogeneous nature and determine saturation fronts. Such type of imaging requires however a complete modelling of the seismoelectric properties of porous media saturated by two immiscible fluid phases, one being usually electrically insulating (for instance water and oil). We combine an extension of Biot dynamic theory, valid for porous media containing two immiscible Newtonian fluids, with an extension of the electrokinetic theory based on the notion of effective volumetric charge densities dragged by the flow of each fluid phase. These effective charge densities can be related directly to the permeability and saturation of each fluid phase. The coupled partial differential equations are solved with the finite element method. We also derive analytically the transfer function connecting the macroscopic electrical field to the acceleration of the fast P wave (coseismic electrical field) and we study the influence of the water content on this coupling. We observe that the amplitude of the co-seismic electrical disturbance is very sensitive to the water content with an increase in amplitude with water saturation. We also investigate the seismoelectric conversions (interface effect) occurring at the water table. We show that the conversion response at the water table can be identifiable only when the saturation contrasts between the vadose and saturated zones are sharp enough. A relatively dry vadose zone represents the best condition to identify the water table through seismoelectric measurements. Indeed, in this case, the coseismic electrical disturbances are vanishingly small compared to the seismoelectric interface response.

  12. Fluid Phase Separation (FPS) experiment for flight on the shuttle in a Get Away Special (GAS) canister: Design and fabrication

    Science.gov (United States)

    1990-01-01

    The separation of fluid phases in microgravity environments is of importance to environmental control and life support systems (ECLSS) and materials processing in space. A successful fluid phase separation experiment will demonstrate a proof of concept for the separation technique and add to the knowledge base of material behavior. The phase separation experiment will contain a premixed fluid that will be exposed to a microgravity environment. After the phase separation of the compound has occurred, small samples of each of the species will be taken for analysis on Earth. By correlating the time of separation and the temperature history of the fluid, it will be possible to characterize the process. The phase separation experiment is totally self-contained, with three levels of containment on all fluids, and provides all necessary electrical power and control. The controller regulates the temperature of the fluid and controls data logging and sampling. An astronaut-activated switch will initiate the experiment and an unmaskable interrupt is provided for shutdown. The experiment has been integrated into space available on a manifested Get Away Special (GAS) experiment, CONCAP 2, part of the Consortium for Materials Complex Autonomous Payload (CAP) Program, scheduled for STS 42 in April 1991. Presented here are the design and the production of a fluid phase separation experiment for rapid implementation at low cost.

  13. Modeling mechanical properties of a shear thickening fluid damper based on phase transition theory

    Science.gov (United States)

    Wei, Minghai; Lin, Kun; Guo, Qian

    2018-03-01

    Shear thickening fluids (STFs) are highly concentrated colloidal suspensions consisting of monodisperse nano-particles suspended in a carrying fluid, and have the capacity to display both flowable and rigid behaviors, when subjected to sudden stimuli. In that process, the external energy that acts on an STF can be dissipated quickly. The aim of this study is to present a dynamic model of a damper filled with STF that can be directly used in control engineering fields. To this end, shear stress during phase transition of the STF material is chosen as an internal variable. A non-convex function with bifurcation behavior is used to describe the phase transitioning of STF by determining the relationship between the behavioral characteristics of the microscopic phase and macroscopic damping force. This model is able to predict force-velocity and force-displacement relationships as functions of the loading frequency. Efficacy of the model is demonstrated via comparison with experimental results from previous studies. In addition, the results confirm the hypothesis regarding the occurrence of STF phase transitioning when subject to shear stress.

  14. Anomalous interfacial tension temperature dependence of condensed phase drops in magnetic fluids

    Science.gov (United States)

    Ivanov, Aleksey S.

    2018-05-01

    Interfacial tension temperature dependence σ(T) of the condensed phase (drop-like aggregates) in magnetic fluids undergoing field induced phase transition of the "gas-liquid" type was studied experimentally. Numerical analysis of the experimental data has revealed the anomalous (if compared to ordinary one-component fluids) behavior of the σ(T) function for all tested magnetic colloid samples: the condensed phase drops at high T ≈ 75 C exhibit higher σ(T) than the drops condensed at low T ≈ 20 C. The σ(T) behavior is explained by the polydispersity of magnetic colloids: at high T, only the largest colloidal particles are able to take part in the field induced condensation; thus, the increase of T causes the growth of the average particle diameters inside the drop-like aggregates, what in its turn results in the growth of σ(T). The result is confirmed by qualitative theoretical estimations and qualitative experimental observation of the condensed phase "evaporation" process after the applied magnetic field is removed: the drops that are formed due to capillary instability of the drop-like aggregates retract by one order of magnitude faster at high T, and the evaporation of the drops slows down at high T.

  15. Assessment of fluid distribution and flow properties in two phase fluid flow using X-ray CT technology

    Science.gov (United States)

    Jiang, Lanlan; Wu, Bohao; Li, Xingbo; Wang, Sijia; Wang, Dayong; Zhou, Xinhuan; Zhang, Yi

    2018-04-01

    To study on microscale distribution of CO2 and brine during two-phase flow is crucial for understanding the trapping mechanisms of CO2 storage. In this study, CO2-brine flow experiments in porous media were conducted using X-ray computed tomography. The porous media were packed with glass beads. The pore structure (porosity/tortuosity) and flow properties at different flow rates and flow fractions were investigated. The results showed that porosity of the packed beads differed at different position as a result of heterogeneity. The CO2 saturation is higher at low injection flow rates and high CO2 fractions. CO2 distribution at the pore scale was also visualized. ∅ Porosity of porous media CT brine_ sat grey value of sample saturated with brine CT dry grey value of sample saturated with air CT brine grey value of pure brine CT air grey value of pure air CT flow grey values of sample with two fluids occupying the pore space {CT}_{CO_2_ sat} grey value of sample saturated with CO2 {f}_{CO_2}({S}_{CO_2}) CO2 fraction {q}_{CO_2} the volume flow rate for CO2 q brine the volume flow rate for brine L Thickness of the porous media, mm L e a bundle of capillaries of equal length, mm τ Tortuosity, calculated from L e / L.

  16. Enantioselective potential of polysaccharide-based chiral stationary phases in supercritical fluid chromatography.

    Science.gov (United States)

    Kucerova, Gabriela; Kalikova, Kveta; Tesarova, Eva

    2017-06-01

    The enantioselective potential of two polysaccharide-based chiral stationary phases for analysis of chiral structurally diverse biologically active compounds was evaluated in supercritical fluid chromatography using a set of 52 analytes. The chiral selectors immobilized on 2.5 μm silica particles were tris-(3,5-dimethylphenylcarmabate) derivatives of cellulose or amylose. The influence of the polysaccharide backbone, different organic modifiers, and different mobile phase additives on retention and enantioseparation was monitored. Conditions for fast baseline enantioseparation were found for the majority of the compounds. The success rate of baseline and partial enantioseparation with cellulose-based chiral stationary phase was 51.9% and 15.4%, respectively. Using amylose-based chiral stationary phase we obtained 76.9% of baseline enantioseparations and 9.6% of partial enantioseparations of the tested compounds. The best results on cellulose-based chiral stationary phase were achieved particularly with propane-2-ol and a mixture of isopropylamine and trifluoroacetic acid as organic modifier and additive to CO 2 , respectively. Methanol and basic additive isopropylamine were preferred on amylose-based chiral stationary phase. The complementary enantioselectivity of the cellulose- and amylose-based chiral stationary phases allows separation of the majority of the tested structurally different compounds. Separation systems were found to be directly applicable for analyses of biologically active compounds of interest. © 2017 Wiley Periodicals, Inc.

  17. Phase-space analysis of the cosmological 3-fluid problem: families of attractors and repellers

    International Nuclear Information System (INIS)

    Azreg-Aïnou, Mustapha

    2013-01-01

    We perform a phase-space analysis of the cosmological 3-fluid problem consisting of a barotropic fluid with an equation-of-state parameter γ − 1, a pressureless dark matter fluid, plus a scalar field ϕ (representing dark energy) coupled to an exponential potential V = V 0 exp ( − κλϕ). Besides the potential–kinetic scaling solutions, which are not the unique late-time attractors whenever they exist for λ 2 ⩾ 3γ, we derive new attractors where both dark energy and dark matter coexist and the final density is shared in a way independent of the value of γ > 1. The case of a pressureless barotropic fluid (γ = 1) has a one-parameter family of attractors where all components coexist. New one-parameter families of matter–dark matter saddle points and kinetic–matter repellers exist. We investigate the stability of the ten critical points by linearization and/or Lyapunov's theorems and a variant of the theorems formulated in this paper. A solution with two transient periods of acceleration and two transient periods of deceleration is derived. (paper)

  18. Even distribution/dividing of single-phase fluids by symmetric bifurcation of flow channels

    International Nuclear Information System (INIS)

    Liu, Hong; Li, Peiwen

    2013-01-01

    Highlights: ► We addressed an issue of distributing a flow to a number of flow channels uniformly. ► The flow distribution is accomplished through bifurcation of channels. ► Some key parameters to the flow distribution uniformity have been identified. ► Flow uniformity was studied for several versions of flow distributor designs. ► A novel fluid packaging device of high efficiency was provided. -- Abstract: This study addresses a fundamental issue of distributing a single-phase fluid flow into a number of flow channels uniformly. A basic mechanism of flow distribution is accomplished through bifurcation of channels that symmetrically split one flow channel into two downstream channels. Applying the basic mechanism, cascades flow distributions are designed to split one flow into a large number of downstream flows uniformly. Some key parameters decisive to the flow distribution uniformity in such a system have been identified, and the flow distribution uniformity of air was studied for several versions of flow distributor designs using CFD analysis. The effect of the key parameters of the flow channel designs to the flow distribution uniformity was investigated. As an example of industrial application, a novel fluid packaging device of high efficiency was proposed and some CFD analysis results for the device were provided. The optimized flow distributor makes a very good uniform flow distribution which will significantly improve the efficiency of fluid packaging. The technology is expected to be of great significance to many industrial devices that require high uniformity of flow distribution

  19. Conditions and phase shift of fluid resonance in narrow gaps of bottom mounted caissons

    Science.gov (United States)

    Zhu, Da-tong; Wang, Xing-gang; Liu, Qing-jun

    2017-12-01

    This paper studies the viscid and inviscid fluid resonance in gaps of bottom mounted caissons on the basis of the plane wave hypothesis and full wave model. The theoretical analysis and the numerical results demonstrate that the condition for the appearance of fluid resonance in narrow gaps is kh=(2 n+1)π ( n=0, 1, 2, 3, …), rather than kh= nπ ( n=0, 1, 2, 3, …); the transmission peaks in viscid fluid are related to the resonance peaks in the gaps. k and h stand for the wave number and the gap length. The combination of the plane wave hypothesis or the full wave model with the local viscosity model can accurately determine the heights and the locations of the resonance peaks. The upper bound for the appearance of fluid resonance in gaps is 2 b/ Lreason for the phase shift of the resonance peaks is the inductive factors. The number of resonance peaks in the spectrum curve is dependent on the ratio of the gap length to the grating constant. The heights and the positions of the resonance peaks predicted by the present models agree well with the experimental data.

  20. Thermal Marangoni convection in two-phase flow of dusty Casson fluid

    Science.gov (United States)

    Mahanthesh, B.; Gireesha, B. J.

    2018-03-01

    This paper deals with the thermal Marangoni convection effects in magneto-Casson liquid flow through suspension of dust particles. The transpiration cooling aspect is accounted. The surface tension is assumed to be fluctuating linearly with temperature. The fluid and dust particle's temperature of the interface is chosen as a quadratic function of interface arc length. The governing problem is modelled by conservation laws of mass, momentum and energy for fluid and dust particle phase. Stretching transformation technique is utilized to form ordinary differential equations from the partial differential equations. Later, the numerical solutions based on Runge-Kutta-Fehlberg method are established. The momentum and heat transport distributions are focused on the outcome of distinct governing parameters. The results of Nusselt number is also presented and discussed. It is established that the heat transfer rate is higher in the case of dusty non-Newtonian fluid than dusty Newtonian fluid. The rate of heat transfer can be enhanced by suspending dust particles in a base liquid.

  1. Phase behavior of the modified-Yukawa fluid and its sticky limit.

    Science.gov (United States)

    Schöll-Paschinger, Elisabeth; Valadez-Pérez, Néstor E; Benavides, Ana L; Castañeda-Priego, Ramón

    2013-11-14

    Simple model systems with short-range attractive potentials have turned out to play a crucial role in determining theoretically the phase behavior of proteins or colloids. However, as pointed out by D. Gazzillo [J. Chem. Phys. 134, 124504 (2011)], one of these widely used model potentials, namely, the attractive hard-core Yukawa potential, shows an unphysical behavior when one approaches its sticky limit, since the second virial coefficient is diverging. However, it is exactly this second virial coefficient that is typically used to depict the experimental phase diagram for a large variety of complex fluids and that, in addition, plays an important role in the Noro-Frenkel scaling law [J. Chem. Phys. 113, 2941 (2000)], which is thus not applicable to the Yukawa fluid. To overcome this deficiency of the attractive Yukawa potential, D. Gazzillo has proposed the so-called modified hard-core attractive Yukawa fluid, which allows one to correctly obtain the second and third virial coefficients of adhesive hard-spheres starting from a system with an attractive logarithmic Yukawa-like interaction. In this work we present liquid-vapor coexistence curves for this system and investigate its behavior close to the sticky limit. Results have been obtained with the self-consistent Ornstein-Zernike approximation (SCOZA) for values of the reduced inverse screening length parameter up to 18. The accuracy of SCOZA has been assessed by comparison with Monte Carlo simulations.

  2. Microtomography and pore-scale modeling of two-phase Fluid Distribution

    Energy Technology Data Exchange (ETDEWEB)

    Silin, D.; Tomutsa, L.; Benson, S.; Patzek, T.

    2010-10-19

    Synchrotron-based X-ray microtomography (micro CT) at the Advanced Light Source (ALS) line 8.3.2 at the Lawrence Berkeley National Laboratory produces three-dimensional micron-scale-resolution digital images of the pore space of the reservoir rock along with the spacial distribution of the fluids. Pore-scale visualization of carbon dioxide flooding experiments performed at a reservoir pressure demonstrates that the injected gas fills some pores and pore clusters, and entirely bypasses the others. Using 3D digital images of the pore space as input data, the method of maximal inscribed spheres (MIS) predicts two-phase fluid distribution in capillary equilibrium. Verification against the tomography images shows a good agreement between the computed fluid distribution in the pores and the experimental data. The model-predicted capillary pressure curves and tomography-based porosimetry distributions compared favorably with the mercury injection data. Thus, micro CT in combination with modeling based on the MIS is a viable approach to study the pore-scale mechanisms of CO{sub 2} injection into an aquifer, as well as more general multi-phase flows.

  3. Flow regime classification in air-magnetic fluid two-phase flow.

    Science.gov (United States)

    Kuwahara, T; De Vuyst, F; Yamaguchi, H

    2008-05-21

    A new experimental/numerical technique of classification of flow regimes (flow patterns) in air-magnetic fluid two-phase flow is proposed in the present paper. The proposed technique utilizes the electromagnetic induction to obtain time-series signals of the electromotive force, allowing us to make a non-contact measurement. Firstly, an experiment is carried out to obtain the time-series signals in a vertical upward air-magnetic fluid two-phase flow. The signals obtained are first treated using two kinds of wavelet transforms. The data sets treated are then used as input vectors for an artificial neural network (ANN) with supervised training. In the present study, flow regimes are classified into bubbly, slug, churn and annular flows, which are generally the main flow regimes. To validate the flow regimes, a visualization experiment is also performed with a glycerin solution that has roughly the same physical properties, i.e., kinetic viscosity and surface tension, as a magnetic fluid used in the present study. The flow regimes from the visualization are used as targets in an ANN and also used in the estimation of the accuracy of the present method. As a result, ANNs using radial basis functions are shown to be the most appropriate for the present classification of flow regimes, leading to small classification errors.

  4. Thermohydrodynamic analysis of cryogenic liquid turbulent flow fluid film bearings, phase 2

    Science.gov (United States)

    Sanandres, Luis

    1994-01-01

    The Phase 2 (1994) Annual Progress Report presents two major report sections describing the thermal analysis of tilting- and flexure-pad hybrid bearings, and the unsteady flow and transient response of a point mass rotor supported on fluid film bearings. A literature review on the subject of two-phase flow in fluid film bearings and part of the proposed work for 1995 are also included. The programs delivered at the end of 1994 are named hydroflext and hydrotran. Both codes are fully compatible with the hydrosealt (1993) program. The new programs retain the same calculating options of hydrosealt plus the added bearing geometries, and unsteady flow and transient forced response. Refer to the hydroflext & hydrotran User's Manual and Tutorial for basic information on the analysis and instructions to run the programs. The Examples Handbook contains the test bearing cases along with comparisons with experimental data or published analytical values. The following major tasks were completed in 1994 (Phase 2): (1) extension of the thermohydrodynamic analysis and development of computer program hydroflext to model various bearing geometries, namely, tilting-pad hydrodynamic journal bearings, flexure-pad cylindrical bearings (hydrostatic and hydrodynamic), and cylindrical pad bearings with a simple elastic matrix (ideal foil bearings); (2) improved thermal model including radial heat transfer through the bearing stator; (3) calculation of the unsteady bulk-flow field in fluid film bearings and the transient response of a point mass rotor supported on bearings; and (4) a literature review on the subject of two-phase flows and homogeneous-mixture flows in thin-film geometries.

  5. MR phase imaging and cerebrospinal fluid flow in the head and spine

    International Nuclear Information System (INIS)

    Levy, L.M.; Di Chiro, G.

    1990-01-01

    Motion of the cerebrospinal fluid (CSF) in and around the brain spinal cord was examined in healthy subjects and in a number of patients with abnormalities of the CSF circulation. The pulsatile motion of the CSF was determined by spin echo phase (velocity) imaging, sometimes in combination with gradient echo phase contrast cine. Differences in flow patterns across CSF spaces were observed: Flow reversal in the cerebellomedullary cistern and lumbar area relative to cervical CSF, and in the posterior versus the anterior subarachnoid space in the spinal canal. Flow communication was demonstrated in known communicating cysts or cavities. Differences in flow were also noted across spinal narrowing or block, and across the walls of a variety of cystic lesions in the brain and spinal cord. MR phase imaging of CSF flow provides pathophysiological information of potential clinical importance for the assessment of diseases affecting the CSF circulation. (orig.)

  6. Nonequilibrium phase transitions, fluctuations and correlations in an active contractile polar fluid.

    Science.gov (United States)

    Gowrishankar, Kripa; Rao, Madan

    2016-02-21

    We study the patterning, fluctuations and correlations of an active polar fluid consisting of contractile polar filaments on a two-dimensional substrate, using a hydrodynamic description. The steady states generically consist of arrays of inward pointing asters and show a continuous transition from a moving lamellar phase, a moving aster street, to a stationary aster lattice with no net polar order. We next study the effect of spatio-temporal athermal noise, parametrized by an active temperature TA, on the stability of the ordered phases. In contrast to its equilibrium counterpart, we find that the active crystal shows true long range order at low TA. On increasing TA, the asters dynamically remodel, concomitantly we find novel phase transitions characterized by bond-orientational and polar order upon "heating".

  7. Poly(butylene terephthalate) based novel achiral stationary phase investigated under supercritical fluid chromatography conditions.

    Science.gov (United States)

    Nagai, Kanji; Shibata, Tohru; Shinkura, Satoshi; Ohnishi, Atsushi

    2018-05-11

    Poly(butylene terephthalate) based novel stationary phase (SP), composed of planar aromatic phenyl group together with ester group monomer units, was designed for supercritical fluid chromatography (SFC) use. As expected from its structure, this phase shows planarity recognition of isomeric aromatics and closely similar compounds. Interestingly, for most analytes, the retention behavior of this SP is significantly distinct from that of the 2-ethylpyridine based SPs which is among the most well-known SFC dedicated phases. Although the poly(butylene terephthalate) is coated on silica gel, the performance of the column did not change by using extended range modifiers such as THF, dichloromethane or ethyl acetate and column robustness was confirmed by cycle durability testing. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  8. Two-Phase Fluid Simulation Using a Diffuse Interface Model with Peng--Robinson Equation of State

    KAUST Repository

    Qiao, Zhonghua; Sun, Shuyu

    2014-01-01

    In this paper, two-phase fluid systems are simulated using a diffusive interface model with the Peng-Robinson equation of state (EOS), a widely used realistic EOS for hydrocarbon fluid in the petroleum industry. We first utilize the gradient theory

  9. Poly(amidoamine) dendrimers on lipid bilayers II: Effects of bilayer phase and dendrimer termination.

    Science.gov (United States)

    Kelly, Christopher V; Leroueil, Pascale R; Orr, Bradford G; Banaszak Holl, Mark M; Andricioaei, Ioan

    2008-08-07

    The molecular structures and enthalpy release of poly(amidoamine) (PAMAM) dendrimers binding to 1,2-dimyristoyl- sn-glycero-3-phosphocholine (DMPC) bilayers were explored through atomistic molecular dynamics. Three PAMAM dendrimer terminations were examined: protonated primary amine, neutral acetamide, and deprotonated carboxylic acid. Fluid and gel lipid phases were examined to extract the effects of lipid tail mobility on the binding of generation-3 dendrimers, which are directly relevant to the nanoparticle interactions involving lipid rafts, endocytosis, lipid removal, and/or membrane pores. Upon binding to gel phase lipids, dendrimers remained spherical, had a constant radius of gyration, and approximately one-quarter of the terminal groups were in close proximity to the lipids. In contrast, upon binding to fluid phase bilayers, dendrimers flattened out with a large increase in their asphericity and radii of gyration. Although over twice as many dendrimer-lipid contacts were formed on fluid versus gel phase lipids, the dendrimer-lipid interaction energy was only 20% stronger. The greatest enthalpy release upon binding was between the charged dendrimers and the lipid bilayer. However, the stronger binding to fluid versus gel phase lipids was driven by the hydrophobic interactions between the inner dendrimer and lipid tails.

  10. Analysis and Design Tools for Fluid-Structure Interaction with Multi-Body Flexible Structures, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The overall objective of this proposal (Phases I and II) is to develop a robust and accurate solver for fluid-structure interaction computations capable of...

  11. Comparison of twin-fluid atomizers using a phase Doppler analyser

    Energy Technology Data Exchange (ETDEWEB)

    Zaremba, Matouš, E-mail: y116215@stud.fme.vutbr.cz, E-mail: y145527@stud.fme.vutbr.cz, E-mail: jedelsky@fme.vutbr.cz, E-mail: jicha@fme.vutbr.cz; Malý, Milan, E-mail: y116215@stud.fme.vutbr.cz, E-mail: y145527@stud.fme.vutbr.cz, E-mail: jedelsky@fme.vutbr.cz, E-mail: jicha@fme.vutbr.cz; Jedelský, Jan, E-mail: y116215@stud.fme.vutbr.cz, E-mail: y145527@stud.fme.vutbr.cz, E-mail: jedelsky@fme.vutbr.cz, E-mail: jicha@fme.vutbr.cz; Jícha, Miroslav, E-mail: y116215@stud.fme.vutbr.cz, E-mail: y145527@stud.fme.vutbr.cz, E-mail: jedelsky@fme.vutbr.cz, E-mail: jicha@fme.vutbr.cz [Brno University of technology, Technická 2896/2, 616 69 Brno (Czech Republic)

    2014-08-06

    The quality of atomization is crucial in combustion processes, especially in cases of highly viscous fuels. Twin-fluid atomizers have been developed for atomizing heavy and waste fuels and they have undergone significant development in the last decades. Nevertheless, in order to design an atomizer for a given industrial application, a comparison of different atomizers at similar operating conditions is required. This paper focuses on the description and comparison of two internally mixed twin-fluid atomizers at the same operating regime. The Y-jet and the Inverse-effervescent atomizers were examined. The phase-Doppler analyzer was used to measure the velocity and size of droplets in a radial profile in the spray. Data were sorted out into classes with respect to the droplet size and the motion analysis was done for both atomizers.

  12. Study of single- and two-phase fluid transfer between subchannels at Kumamoto University

    International Nuclear Information System (INIS)

    Sadatomi, Michio

    2004-01-01

    Firstly, the definitions of turbulent mixing, void drift and diversion cross-flow, which are three components of fluid transfer between subchannels, are given together with the relations of each component with equilibrium or non-equilibrium two-phase subchannel flows. Secondly, measuring techniques of the three components are briefly presented in turn together with typical measurement results. In turbulent mixing measurement, a tracer injection method has been adopted at Kumamoto University, while an isokinetic discharge method for both void drift an diversion cross-flow measurements. In the experiment of hydraulically non-equilibrium flow with both void drift and/or diversion cross-flow, experimental data on flow redistribution process have been obtained. The data include the axial variations of gas and liquid flow rates and void fraction in each subchannel and pressure difference between the subchannels. After analyzing these variations, some correlations on the void drift and the diversion cross-flow are obtained. Finally, a subchannel analysis code used at Kumamoto University is presented together with the results of its validation test against the experimental data on flow redistribution process mentioned above. The code is based on a two-phase two-fluid model, and is applicable to adiabatic two-phase flows under steady state condition. Basic equations in the code are the conservation equations of mass, axial momentum and lateral momentum, while the constitutive equations include the correlations of void diffusion coefficient, both interfacial and wall friction coefficients for the cross-flow, etc. (author)

  13. On heat transfer to pulsatile flow of a two-phase fluid

    Directory of Open Access Journals (Sweden)

    S. P. Chakraborty

    2005-09-01

    Full Text Available The problem of heat transfer to pulsatile flow of a two-phase fluid-particle system contained in a channel bounded by two infinitely long rigid impervious parallel walls has been studied in this paper. The solutions for the steady and the fluctuating temperature distributions are obtained. The rates of heat transfer at the walls are also calculated. The results are discussed numerically with graphical presentations. It is shown that the presence of the particles not only diminishes the steady and unsteady temperature fields but also decreases the reversal of heat flux at the hotter wall irrespective of the influences of other flow parameters.

  14. Parametric numerical investigaion of natural convection in a heat-generating fluid with phase transitions

    Energy Technology Data Exchange (ETDEWEB)

    Aksenova, A.E.; Chudanov, V.V.; Strizhov, V.F.; Vabishchevich, P.N. [Institute of Nuclear Safety Russian Academy Science, Moscow (Russian Federation)

    1995-09-01

    Unsteady natural convection of a heat-generating fluid with phase transitions in the enclosures of a square section with isothermal rigid walls is investigated numerically for a wide range of dimensionless parameters. The quasisteady state solutions of conjugate heat and mass transfer problem are compared with available experimental results. Correlation relations for heat flux distributions at the domain boundaries depending on Rayleigh and Ostrogradskii numbers are obtained. It is shown that generally heat transfer is governed both by natural circulation and crust formation phenomena. Results of this paper may be used for analysis of experiments with prototypic core materials.

  15. Prominin-2 expression increases protrusions, decreases caveolae and inhibits Cdc42 dependent fluid phase endocytosis

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Raman Deep, E-mail: Takhter.Ramandeep@mayo.edu; Schroeder, Andreas S.; Scheffer, Luana; Holicky, Eileen L.; Wheatley, Christine L.; Marks, David L., E-mail: Marks.david@mayo.edu; Pagano, Richard E.

    2013-05-10

    Highlights: •Prominin-2 expression induced protrusions that co-localized with lipid raft markers. •Prominin-2 expression decreased caveolae, caveolar endocytosis and increased pCav1. •Prominin-2 expression inhibited fluid phase endocytosis by inactivation of Cdc42. •These endocytic effects can be reversed by adding exogenous cholesterol. •Caveolin1 knockdown restored fluid phase endocytosis in Prominin2 expressing cells. -- Abstract: Background: Membrane protrusions play important roles in biological processes such as cell adhesion, wound healing, migration, and sensing of the external environment. Cell protrusions are a subtype of membrane microdomains composed of cholesterol and sphingolipids, and can be disrupted by cholesterol depletion. Prominins are pentaspan membrane proteins that bind cholesterol and localize to plasma membrane (PM) protrusions. Prominin-1 is of great interest as a marker for stem and cancer cells, while Prominin-2 (Prom2) is reportedly restricted to epithelial cells. Aim: To characterize the effects of Prom-2 expression on PM microdomain organization. Methods: Prom2-fluorescent protein was transfected in human skin fibroblasts (HSF) and Chinese hamster ovary (CHO) cells for PM raft and endocytic studies. Caveolae at PM were visualized using transmission electron microscopy. Cdc42 activation was measured and caveolin-1 knockdown was performed using siRNAs. Results: Prom2 expression in HSF and CHO cells caused extensive Prom2-positive protrusions that co-localized with lipid raft markers. Prom2 expression significantly decreased caveolae at the PM, reduced caveolar endocytosis and increased caveolin-1 phosphorylation. Prom2 expression also inhibited Cdc42-dependent fluid phase endocytosis via decreased Cdc42 activation. Effects on endocytosis were reversed by addition of cholesterol. Knockdown of caveolin-1 by siRNA restored Cdc42 dependent fluid phase endocytosis in Prom2-expressing cells. Conclusions: Prom2 protrusions primarily

  16. A Well-Posed Two Phase Flow Model and its Numerical Solutions for Reactor Thermal-Fluids Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kadioglu, Samet Y. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Berry, Ray [Idaho National Lab. (INL), Idaho Falls, ID (United States); Martineau, Richard [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-08-01

    A 7-equation two-phase flow model and its numerical implementation is presented for reactor thermal-fluids applications. The equation system is well-posed and treats both phases as compressible flows. The numerical discretization of the equation system is based on the finite element formalism. The numerical algorithm is implemented in the next generation RELAP-7 code (Idaho National Laboratory (INL)’s thermal-fluids code) built on top of an other INL’s product, the massively parallel multi-implicit multi-physics object oriented code environment (MOOSE). Some preliminary thermal-fluids computations are presented.

  17. A Well-Posed Two Phase Flow Model and its Numerical Solutions for Reactor Thermal-Fluids Analysis

    International Nuclear Information System (INIS)

    Kadioglu, Samet Y.; Berry, Ray; Martineau, Richard

    2016-01-01

    A 7-equation two-phase flow model and its numerical implementation is presented for reactor thermal-fluids applications. The equation system is well-posed and treats both phases as compressible flows. The numerical discretization of the equation system is based on the finite element formalism. The numerical algorithm is implemented in the next generation RELAP-7 code (Idaho National Laboratory (INL)'s thermal-fluids code) built on top of an other INL's product, the massively parallel multi-implicit multi-physics object oriented code environment (MOOSE). Some preliminary thermal-fluids computations are presented.

  18. Numerical approximation of a binary fluid-surfactant phase field model of two-phase incompressible flow

    KAUST Repository

    Zhu, Guangpu

    2018-04-17

    In this paper, we consider the numerical approximation of a binary fluid-surfactant phase field model of two-phase incompressible flow. The nonlinearly coupled model consists of two Cahn-Hilliard type equations and incompressible Navier-Stokes equations. Using the Invariant Energy Quadratization (IEQ) approach, the governing system is transformed into an equivalent form, which allows the nonlinear potentials to be treated efficiently and semi-explicitly. we construct a first and a second-order time marching schemes, which are extremely efficient and easy-to-implement, for the transformed governing system. At each time step, the schemes involve solving a sequence of linear elliptic equations, and computations of phase variables, velocity and pressure are totally decoupled. We further establish a rigorous proof of unconditional energy stability for the semi-implicit schemes. Numerical results in both two and three dimensions are obtained, which demonstrate that the proposed schemes are accurate, efficient and unconditionally energy stable. Using our schemes, we investigate the effect of surfactants on droplet deformation and collision under a shear flow. The increase of surfactant concentration can enhance droplet deformation and inhibit droplet coalescence.

  19. Numerical approximation of a binary fluid-surfactant phase field model of two-phase incompressible flow

    KAUST Repository

    Zhu, Guangpu; Kou, Jisheng; Sun, Shuyu; Yao, Jun; Li, Aifen

    2018-01-01

    In this paper, we consider the numerical approximation of a binary fluid-surfactant phase field model of two-phase incompressible flow. The nonlinearly coupled model consists of two Cahn-Hilliard type equations and incompressible Navier-Stokes equations. Using the Invariant Energy Quadratization (IEQ) approach, the governing system is transformed into an equivalent form, which allows the nonlinear potentials to be treated efficiently and semi-explicitly. we construct a first and a second-order time marching schemes, which are extremely efficient and easy-to-implement, for the transformed governing system. At each time step, the schemes involve solving a sequence of linear elliptic equations, and computations of phase variables, velocity and pressure are totally decoupled. We further establish a rigorous proof of unconditional energy stability for the semi-implicit schemes. Numerical results in both two and three dimensions are obtained, which demonstrate that the proposed schemes are accurate, efficient and unconditionally energy stable. Using our schemes, we investigate the effect of surfactants on droplet deformation and collision under a shear flow. The increase of surfactant concentration can enhance droplet deformation and inhibit droplet coalescence.

  20. Geometric analysis of the solutions of two-phase flows: two-fluid model

    International Nuclear Information System (INIS)

    Kestin, J.; Zeng, D.L.

    1984-01-01

    This report contains a lightly edited draft of a study of the two-fluid model in two-phase flow. The motivation for the study stems from the authors' conviction that the construction of a computer code for any model should be preceded by a geometrical analysis of the pattern of trajectories in the phase space appropriate for the model. Such a study greatly facilitates the understanding of the phenomenon of choking and anticipates the computational difficulties which arise from the existence of singularities. The report contains a derivation of the six conservation equations of the model which includes a consideration of the simplifications imposed on a one-dimensional treatment by the presence of boundary layers at the wall and between the phases. The model is restricted to one-dimensional adiabatic flows of a single substance present in two phases, but thermodynamic equilibrium between the phases is not assumed. The role of closure conditions is defined but no specific closure conditions, or explicit equations of state, are introduced

  1. Evaluation of an amide-based stationary phase for supercritical fluid chromatography

    Science.gov (United States)

    Borges-Muñoz, Amaris C.; Colón, Luis A.

    2017-01-01

    A relatively new stationary phase containing a polar group embedded in a hydrophobic backbone (i.e., ACE® C18-amide) was evaluated for use in supercritical fluid chromatography. The amide-based column was compared with columns packed with bare silica, C18 silica, and a terminal-amide silica phase. The system was held at supercritical pressure and temperature with a mobile phase composition of CO2 and methanol as cosolvent. The linear solvation energy relationship model was used to evaluate the behavior of these stationary phases, relating the retention factor of selected probes to specific chromatographic interactions. A five-component test mixture, consisting of a group of drug-like molecules was separated isocratically. The results show that the C18-amide stationary phase provided a combination of interactions contributing to the retention of the probe compounds. The hydrophobic interactions are favorable; however, the electron donating ability of the embedded amide group shows a large positive interaction. Under the chromatographic conditions used, the C18-amide column was able to provide baseline resolution of all the drug-like probe compounds in a text mixture, while the other columns tested did not. PMID:27396487

  2. Characterization of Phase Transition in Heisenberg Fluids from Density Functional Theory

    International Nuclear Information System (INIS)

    Li Liangsheng; Li Li; Chen Xiaosong

    2009-01-01

    The phase transition of Heisenberg fluid has been investigated with the density functional theory in mean-field approximation (MF). The matrix of the second derivatives of the grand canonical potential Ω with respect to the particle density fluctuations and the magnetization fluctuations has been investigated and diagonalized. The smallest eigenvalue being 0 signalizes the phase instability and the related eigenvector characterizes this phase transition. We find a Curie line where the order parameter is pure magnetization and a spinodal where the order parameter is a mixture of particle density and magnetization. Along the spinodal, the character of phase instability changes continuously from predominant condensation to predominant ferromagnetic phase transition with the decrease of total density. The spinodal meets the Curie line at the critical endpoint with the reduced density ρ* = ρσ 3 = 0.224 and the reduced temperature T* = kT/ element of = 1.87 (σ is the diameter of Heisenberg hard sphere and element of is the coupling constant).

  3. Unsteady flow of two-phase fluid in circular pipes under applied external magnetic and electrical fields

    International Nuclear Information System (INIS)

    Gedik, Engin; Recebli, Ziyaddin; Kurt, Hueseyin; Kecebas, Ali

    2012-01-01

    The unsteady viscous incompressible and electrically conducting of two-phase fluid flow in circular pipes with external magnetic and electrical field is considered in this present study. Effects of both uniform transverse external magnetic and electrical fields applied perpendicular to the fluid and each other on the two-phase (solid/liquid) unsteady flow is investigated numerically. While iron powders are being used as the first phase of two-phase fluid, pure water was used as the second phase. The system of the derived governing equations, which are based on the Navier-Stokes equations including Maxwell equations, are solved numerically by using Pdex4 function on the Matlab for both phases. The originality of this study is that, in addition to magnetic field, the effect of electrical field on two-phase unsteady fluids is being examined. The magnetic field which is applied on flow decreases the velocity of both phases, whereas the electrical field applied along with magnetic field acted to increase and decrease the velocity values depending on the direction of electrical field. Electrical field alone did not display any impact on two-phase flow. On the other hand, analytical and numerical results are compared and favorable agreements have been obtained. (authors)

  4. CFD simulation of gas and non-Newtonian fluid two-phase flow in anaerobic digesters.

    Science.gov (United States)

    Wu, Binxin

    2010-07-01

    This paper presents an Eulerian multiphase flow model that characterizes gas mixing in anaerobic digesters. In the model development, liquid manure is assumed to be water or a non-Newtonian fluid that is dependent on total solids (TS) concentration. To establish the appropriate models for different TS levels, twelve turbulence models are evaluated by comparing the frictional pressure drops of gas and non-Newtonian fluid two-phase flow in a horizontal pipe obtained from computational fluid dynamics (CFD) with those from a correlation analysis. The commercial CFD software, Fluent12.0, is employed to simulate the multiphase flow in the digesters. The simulation results in a small-sized digester are validated against the experimental data from literature. Comparison of two gas mixing designs in a medium-sized digester demonstrates that mixing intensity is insensitive to the TS in confined gas mixing, whereas there are significant decreases with increases of TS in unconfined gas mixing. Moreover, comparison of three mixing methods indicates that gas mixing is more efficient than mixing by pumped circulation while it is less efficient than mechanical mixing.

  5. Workshop on Two-Phase Fluid Behavior in a Space Environment

    Science.gov (United States)

    Swanson, Theodore D. (Editor); Juhasz, AL (Editor); Long, W. Russ (Editor); Ottenstein, Laura (Editor)

    1989-01-01

    The Workshop was successful in achieving its main objective of identifying a large number of technical issues relating to the design of two-phase systems for space applications. The principal concern expressed was the need for verified analytical tools that will allow an engineer to confidently design a system to a known degree of accuracy. New and improved materials, for such applications as thermal storage and as heat transfer fluids, were also identified as major needs. In addition to these research efforts, a number of specific hardware needs were identified which will require development. These include heat pumps, low weight radiators, advanced heat pipes, stability enhancement devices, high heat flux evaporators, and liquid/vapor separators. Also identified was the need for a centralized source of reliable, up-to-date information on two-phase flow in a space environment.

  6. Rapid purification of diastereoisomers from Piper kadsura using supercritical fluid chromatography with chiral stationary phases.

    Science.gov (United States)

    Xin, Huaxia; Dai, Zhuoshun; Cai, Jianfeng; Ke, Yanxiong; Shi, Hui; Fu, Qing; Jin, Yu; Liang, Xinmiao

    2017-08-04

    Supercritical fluid chromatography (SFC) with chiral stationary phases (CSPs) is an advanced solution for the separation of achiral compounds in Piper kadsura. Analogues and stereoisomers are abundant in natural products, but there are obstacles in separation using conventional method. In this paper, four lignan diastereoisomers, (-)-Galbelgin, (-)-Ganschisandrin, Galgravin and (-)-Veraguensin, from Piper kadsura were separated and purified by chiral SFC. Purification strategy was designed, considering of the compound enrichment, sample purity and purification throughput. Two-step achiral purification method on chiral preparative columns with stacked automated injections was developed. Unconventional mobile phase modifier dichloromethane (DCM) was applied to improve the sample solubility. Four diastereoisomers was prepared at the respective weight of 103.1mg, 10.0mg, 152.3mg and 178.6mg from 710mg extract with the purity of greater than 98%. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. A Multi-Phase Based Fluid-Structure-Microfluidic interaction sensor for Aerodynamic Shear Stress

    Science.gov (United States)

    Hughes, Christopher; Dutta, Diganta; Bashirzadeh, Yashar; Ahmed, Kareem; Qian, Shizhi

    2014-11-01

    A novel innovative microfluidic shear stress sensor is developed for measuring shear stress through multi-phase fluid-structure-microfluidic interaction. The device is composed of a microfluidic cavity filled with an electrolyte liquid. Inside the cavity, two electrodes make electrochemical velocimetry measurements of the induced convection. The cavity is sealed with a flexible superhydrophobic membrane. The membrane will dynamically stretch and flex as a result of direct shear cross-flow interaction with the seal structure, forming instability wave modes and inducing fluid motion within the microfluidic cavity. The shear stress on the membrane is measured by sensing the induced convection generated by membrane deflections. The advantages of the sensor over current MEMS based shear stress sensor technology are: a simplified design with no moving parts, optimum relationship between size and sensitivity, no gaps such as those created by micromachining sensors in MEMS processes. We present the findings of a feasibility study of the proposed sensor including wind-tunnel tests, microPIV measurements, electrochemical velocimetry, and simulation data results. The study investigates the sensor in the supersonic and subsonic flow regimes. Supported by a NASA SBIR phase 1 contract.

  8. Preparation of nanoencapsulated phase change material as latent functionally thermal fluid

    Energy Technology Data Exchange (ETDEWEB)

    Fang Yutang; Kuang Shengyan; Gao Xuenong; Zhang Zhengguo, E-mail: ppytfang@scut.edu.c [Key Laboratory of Enhanced Heat Transfer and Energy Conservation, Ministry of Education, South China University of Technology, Guangzhou 510640 (China)

    2009-02-07

    Nanoencapsulated phase change material with polystyrene as the shell and n-octadecane as the core was synthesized using the ultrasonic technique and miniemulsion in situ polymerization. The influences of polymerization factors, including initiator, chain transfer agent (CTA), surfactant, n-octadecane/styrene ratio and hydrophilic co-monomer, on the morphology and thermophysical properties of nanocapsules were systematically investigated. The optimized polymerization conditions were 0.5 wt% of initiator (2,2-azobisisobutyronitrile), 0.4 wt% of CTA (n-dodecyl mercaptan), 2% of composite surfactants which were composed of sodium dodecyl sulfate and poly-(ethylene glycol) monooctylphenyl ether by 1 : 1 in weight ratio, 1 wt% of hydrophilic co-monomer butyl acrylate or 3 wt% of methyl methacrylate and 1 : 1 n-octadecane to styrene in weight ratio. Under these conditions, the z-average size of prepared nanocapsules was 124 nm and the phase change enthalpy was 124.4 kJ kg{sup -1}. The heat capacity was as high as 11.61 kJ kg{sup -1} K{sup -1} at the latex concentration of 20.6 wt%. Thermal stability and viscosity testing show that this fluid had excellent resistance to thermal shock (after 100 cycles, no liquid Oct was observed during heating) and low viscosity (only 3.61 mPa s at the latex concentration of 20.6 wt%), which seems to be promising as a latent functionally thermal fluid.

  9. An equivalent ground thermal test method for single-phase fluid loop space radiator

    Directory of Open Access Journals (Sweden)

    Xianwen Ning

    2015-02-01

    Full Text Available Thermal vacuum test is widely used for the ground validation of spacecraft thermal control system. However, the conduction and convection can be simulated in normal ground pressure environment completely. By the employment of pumped fluid loops’ thermal control technology on spacecraft, conduction and convection become the main heat transfer behavior between radiator and inside cabin. As long as the heat transfer behavior between radiator and outer space can be equivalently simulated in normal pressure, the thermal vacuum test can be substituted by the normal ground pressure thermal test. In this paper, an equivalent normal pressure thermal test method for the spacecraft single-phase fluid loop radiator is proposed. The heat radiation between radiator and outer space has been equivalently simulated by combination of a group of refrigerators and thermal electrical cooler (TEC array. By adjusting the heat rejection of each device, the relationship between heat flux and surface temperature of the radiator can be maintained. To verify this method, a validating system has been built up and the experiments have been carried out. The results indicate that the proposed equivalent ground thermal test method can simulate the heat rejection performance of radiator correctly and the temperature error between in-orbit theory value and experiment result of the radiator is less than 0.5 °C, except for the equipment startup period. This provides a potential method for the thermal test of space systems especially for extra-large spacecraft which employs single-phase fluid loop radiator as thermal control approach.

  10. Enantioseparation of novel chiral sulfoxides on chlorinated polysaccharide stationary phases in supercritical fluid chromatography.

    Science.gov (United States)

    West, Caroline; Konjaria, Mari-Luiza; Shashviashvili, Natia; Lemasson, Elise; Bonnet, Pascal; Kakava, Rusudan; Volonterio, Alessandro; Chankvetadze, Bezhan

    2017-05-26

    Asymmetric sulfoxides is a particular case of chirality that may be found in natural as well as synthetic products. Twenty-four original molecules containing a sulfur atom as a centre of chirality were analyzed in supercritical fluid chromatography on seven polysaccharide-based chiral stationary phases (CSP) with carbon dioxide - methanol mobile phases. While all the tested CSP provided enantioseparation for a large part of the racemates, chlorinated cellulosic phases proved to be both highly retentive and highly enantioselective towards these species. Favourable structural features were determined by careful comparison of the enantioseparation of the probe molecules. Molecular modelling studies indicate that U-shaped (folded) conformations were most favorable to achieve high enantioresolution on these CSP, while linear (extended) conformations were not so clearly discriminated. For a subset of these species adopting different conformations, a broad range of mobile phase compositions, ranging from 20 to 100% methanol in carbon dioxide, were investigated. While retention decreased continuously in this range, enantioseparation varied in a non-monotonous fashion. Abrupt changes in the tendency curves of retention and selectivity were observed when methanol proportion reaches about 60%, suggesting that a change in the conformation of the analytes and/or chiral selector is occurring at this point. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Phase II trial of isotonic fluid resuscitation in Kenyan children with severe malnutrition and hypovolaemia

    Directory of Open Access Journals (Sweden)

    Boga Mwanamvua

    2010-10-01

    Full Text Available Abstract Background Children with severe malnutrition who develop shock have a high mortality. Contrary to contemporaneous paediatric practice, current guidelines recommend use of low dose hypotonic fluid resuscitation (half-strength Darrows/5% dextrose (HSD/5D. We evaluated the safety and efficacy of this guideline compared to resuscitation with a standard isotonic solution. Methods A Phase II randomised controlled, safety and efficacy trial in Kenyan children aged over 6 months with severe malnutrition and shock including children with severe dehydration/shock and presumptive septic shock (non-diarrhoeal shock. Eligible children were randomised to HSD/5D or Ringer's Lactate (RL. A maximum of two boluses of 15 ml/kg of HSD/5D were given over two hours (as recommended by guidelines while those randomised to RL received 10 ml/kg aliquots half hourly (maximum 40 ml/kg. Primary endpoint was resolution of shock at 8 and 24 hours. Secondary outcomes included resolution of acidosis, adverse events and mortality. Results 61 children were enrolled: 41 had shock and severe dehydrating diarrhoea, 20 had presumptive septic shock; 69% had decompensated shock. By 8 hours response to volume resuscitation was poor with shock persisting in most children:-HSD/5D 15/22 (68% and RL14/25 (52%, p = 0.39. Oliguria was more prevalent at 8 hours in the HSD/5D group, 9/22 (41%, compared to RL-3/25 (12%, p = 0.02. Mortality was high, HSD/5D-15/26(58% and RL 13/29(45%; p = 0.42. Most deaths occurred within 48 hours of admission. Neither pulmonary oedema nor cardiogenic failure was detected. Conclusions Outcome was universally poor characterised by persistence of shock, oliguria and high case fatality. Isotonic fluid was associated with modest improvement in shock and survival when compared to HSD/5D but inconclusive due to the limitations of design and effectiveness of either resuscitation strategy. Although isotonic fluid resuscitation did not result in cardiogenic heart

  12. Unravelling the effects of mobile phase additives in supercritical fluid chromatography. Part I: Polarity and acidity of the mobile phase.

    Science.gov (United States)

    West, Caroline; Melin, Jodie; Ansouri, Hassna; Mengue Metogo, Maïly

    2017-04-07

    The mobile phases employed in current supercritical fluid chromatography (SFC) are usually composed of a mixture of pressurized carbon dioxide and a co-solvent. The co-solvent is most often an alcohol and may contain a third component in small proportions, called an additive (acid, base or salt). The polarity of such mobile phase compositions is here re-evaluated with a solvatochromic dye (Nile Red), particularly to assess the contribution of additives. It appears that additives, when employed in usual concentration range (0.1% or 20mM) do not modify the polarity in the immediate environment of the probe. In addition, the combination of carbon dioxide and an alcohol is known to form alkoxylcarbonic acid, supposedly conferring some acidic character to SFC mobile phases. Direct measurements of the apparent pH are impossible, but colour indicators of pH can be used to define the range of apparent pH provided by carbon dioxide-alcohol mixtures, with or without additives. Five colour indicators (Thymol Blue, Bromocresol Green, Methyl Red, Bromocresol Purple, and Bromothymol Blue) were selected to provide a wide range of aqueous pK a values (from 1.7 to 8.9). UV-vis absorption spectra measured in liquid phases of controlled pH were compared to those measured with a diode-array detector employed in SFC, with the help of chemometric methods. Based on these observations, it is concluded that the apparent pH range in carbon dioxide-methanol mobile phases is close to 5. Increasing the proportion of methanol (in the course of a gradient elution for instance) causes decreasing apparent pH. Strong acids can further decrease the apparent pH below 1.7; strong bases have little influence on the apparent pH, probably because, in this range of concentrations, they are titrated by alkoxylcarbonic acid or form ion pairs with alkoxycarbonate. However, bases and salts could stabilize the acidity in the course of gradient runs. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Liquid-vapour phase behaviour of a polydisperse Lennard-Jones fluid

    International Nuclear Information System (INIS)

    Wilding, Nigel B; Sollich, Peter

    2005-01-01

    We describe a simulation study of the liquid-vapour phase behaviour of a model polydisperse fluid. Particle interactions are given by a Lennard-Jones potential in which polydispersity features both in the particle sizes and the amplitude of their interactions. We address the computational problem of accurately locating the cloud curve for such a system using Monte Carlo simulations within the grand canonical ensemble. The strongly nonlinear variation of the fractional volumes of the phases across the coexistence region precludes naive extrapolation to determine the cloud point density. Instead we propose an improved estimator for the cloud point location and use scaling arguments to predicts its finite-size behaviour. Excellent agreement is found with the simulation results. Application of the method reveals that the measured cloud curve is highly sensitive to the presence of large particles, even when they are extremely rare. This finding is expected to have implications for the reproducibility of experimentally measured phase diagrams in colloids and polymers

  14. Liquid and vapor phase fluids visualization using an exciplex chemical sensor

    International Nuclear Information System (INIS)

    Kim, Jong Uk; Kim, Guang Hoon; Kim, Chang Bum; Suk, Hyyong

    2001-01-01

    Two dimensional slices of the cross-sectional distributions of fuel images in the combustion chamber were visualized quantitatively using a laser-induced exciplex (excited state complex) fluorescence technique. A new exciplex visualization system consisting of 5%DMA (N, N-dimethylaniline) · 5%1, 4,6-TMN (trimethylnaphthalene) in 90% isooctane (2,2,4-trimethylpentane) fuel was employed. In this method, the vapor phase was tagged by the monomer fluorescence while the liquid phase was tracked by the red-shifted exciplex fluorescence with good spectral and spatial resolution. The direct calibration of the fluorescence intensity as a function of the fluorescing dopant concentrations then permitted the determination of quantitative concentration maps of liquid and vapor phases in the fuel. The 308 nm (XeCl) line of the excimer laser was used to excite the doped molecules in the fuel and the resulting fluorescence images were obtained with an ICCD detector as a function time. In this paper, the spectroscopy of the exciplex chemical sensors as well as the optical diagnostic method of the fluid distribution is discussed in detail.

  15. Local composition shift of mixed working fluid in gas–liquid flow with phase transition

    International Nuclear Information System (INIS)

    Xu Xiongwen; Liu Jinping; Cao Le; Li Zeyu

    2012-01-01

    Local composition shift is an important characteristic of gas-liquid mixture flow with phase transition. It affects the heat transfer process, stream sonic velocity and the mixture distribution in the thermodynamic cycle. Presently, it is mainly calculated through the empirical models of the void fraction from pure fluid experiments. In this paper, we made efforts to obtain it and its rules basing on conservation equations derivation. The result calculated with propane/i-butane binary mixture was verified by the experiment in the evaporator of a refrigerator. As an extending, it was applied to a ternary mixture with components of methane, propane and butane and more information was presented and analyzed. The calculation approach presented in this paper can be applied any multicomponent mixture, and the rules will be helpful to improve the composition shift theory. - Highlights: ► Local composition shift of mixed working fluid in gas–liquid flow was modelled. ► A solution method for local composition of gas–liquid flow was proposed. ► The solution method was verified by the experimental result. ► Local composition shift mechanism of gas–liquid flow was studied

  16. An Accurate Estimate of the Free Energy and Phase Diagram of All-DNA Bulk Fluids

    Directory of Open Access Journals (Sweden)

    Emanuele Locatelli

    2018-04-01

    Full Text Available We present a numerical study in which large-scale bulk simulations of self-assembled DNA constructs have been carried out with a realistic coarse-grained model. The investigation aims at obtaining a precise, albeit numerically demanding, estimate of the free energy for such systems. We then, in turn, use these accurate results to validate a recently proposed theoretical approach that builds on a liquid-state theory, the Wertheim theory, to compute the phase diagram of all-DNA fluids. This hybrid theoretical/numerical approach, based on the lowest-order virial expansion and on a nearest-neighbor DNA model, can provide, in an undemanding way, a parameter-free thermodynamic description of DNA associating fluids that is in semi-quantitative agreement with experiments. We show that the predictions of the scheme are as accurate as those obtained with more sophisticated methods. We also demonstrate the flexibility of the approach by incorporating non-trivial additional contributions that go beyond the nearest-neighbor model to compute the DNA hybridization free energy.

  17. Fluid simulation of the conduction phase of the plasma erosion opening switch

    International Nuclear Information System (INIS)

    Grossmann, J.M.; Mosher, D.; Ottinger, P.F.

    1987-01-01

    The conduction phase of the plasma erosion openings switch (PEOS) is studied using a 1 1/2-D electromagnetic two-fluid code. The focus of this work is on understanding how two effects, a current-limiting model of electron emission, and the magnetic insulation of electrons at the cathode, determine current conduction in the plasma. Simulations are performed in the parameter regimes of the Gamble I, POP, and PBFA II pulsed power generators, and previous low-density, short-rise time simulations of the PEOS. Fluid code results are compared to a 1-D analytic theory and to the Gamble I and POP experiments. Good agreement between theory and simulation, but mixed agreement between simulation and experiment is found. Experimental Β-field measurements on POP show weaker j x Β compression than the simulation. Current penetration and plasma current channels qualitatively similar to experimental observation are found in the Gamble I regime. However, magnetic insulation of electrons emitted from the cathode bunches the electron flow into narrower current channels than observed experimentally. In several cases, the presence of an electron-scattering or energy-loss mechanism near the cathode must be invoked to overcome magnetic insulation and widen the current channels

  18. Headspace solid-phase microextraction procedures for gas chromatographic analysis of biological fluids and materials.

    Science.gov (United States)

    Mills, G A; Walker, V

    2000-12-01

    Solid-phase microextraction (SPME) is a new solventless sample preparation technique that is finding wide usage. This review provides updated information on headspace SPME with gas chromatographic separation for the extraction and measurement of volatile and semivolatile analytes in biological fluids and materials. Firstly the background to the technique is given in terms of apparatus, fibres used, extraction conditions and derivatisation procedures. Then the different matrices, urine, blood, faeces, breast milk, hair, breath and saliva are considered separately. For each, methods appropriate for the analysis of drugs and metabolites, solvents and chemicals, anaesthetics, pesticides, organometallics and endogenous compounds are reviewed and the main experimental conditions outlined with specific examples. Then finally, the future potential of SPME for the analysis of biological samples in terms of the development of new devices and fibre chemistries and its coupling with high-performance liquid chromatography is discussed.

  19. Thermophysical Properties and Phase Behavior of Fluids for Application in Carbon Capture and Storage Processes.

    Science.gov (United States)

    Trusler, J P Martin

    2017-06-07

    Phase behavior and thermophysical properties of mixtures of carbon dioxide with various other substances are very important for the design and operation of carbon capture and storage (CCS) processes. The available empirical data are reviewed, together with some models for the calculation of these properties. The systems considered in detail are, first, mixtures of carbon dioxide, water, and salts; second, carbon dioxide-rich nonelectrolyte mixtures; and third, mixtures of carbon dioxide with water and amines. The empirical data and the plethora of available models permit the estimation of key fluid properties required in the design and operation of CCS processes. The engineering community would benefit from the further development, and delivery in convenient form, of a small number of these models sufficient to encompass the component slate and operating conditions of CCS processes.

  20. Modeling and analysis of hydrodynamic instabilities in two-phase flow using two-fluid model

    International Nuclear Information System (INIS)

    Zhou, J.; Podowski, M.Z.

    2001-01-01

    Because of the practical importance of two-phase flow instabilities, especially in boiling water nuclear reactor technology, substantial efforts have been made to date to understand the physical phenomena governing such instabilities and to develop computational tools to model the dynamics of marginally-stable/unstable boiling systems. The purpose of this paper is to present an integrated methodology for the analysis of flow-induced instabilities in boiling channels and systems. The major novel aspects of the proposed approach are: (a) it is based on the combined frequency-domain and time-domain methods, the former used to quantify stability margins and to determine the onset of instability conditions, the latter to study the nonlinear system response outside the stability boundaries identified using the nearly-exact results of the frequency-domain analysis; (b) the two-fluid model of two-phase flow has been used for the first time to analytically derive the boiling channel transfer functions for the parallel-channel and channel-to-channel instability modes. In this way, the major characteristics of a boiling system, including the onset-of-instability conditions, can be readily evaluated by using the qualitative frequency-domain approach, whereas the explicit time-domain integration is performed, if necessary, only for the operating conditions that have already been identified as unstable. Both methods use the same physical two-fluid model that, in one case, is linearized and used to derive a rigorous analytical solution in the complex domain, and, in the other case, is solved numerically using an algorithm developed especially for this purpose. The results using both methods have been compared against each other and extensively tested. The testing and validation of the new model included comparisons of the predicted steady-state distributions of major parameters and of the transient channel response against experimental data

  1. Evaluation of two-phase flow solvers using Level Set and Volume of Fluid methods

    Science.gov (United States)

    Bilger, C.; Aboukhedr, M.; Vogiatzaki, K.; Cant, R. S.

    2017-09-01

    Two principal methods have been used to simulate the evolution of two-phase immiscible flows of liquid and gas separated by an interface. These are the Level-Set (LS) method and the Volume of Fluid (VoF) method. Both methods attempt to represent the very sharp interface between the phases and to deal with the large jumps in physical properties associated with it. Both methods have their own strengths and weaknesses. For example, the VoF method is known to be prone to excessive numerical diffusion, while the basic LS method has some difficulty in conserving mass. Major progress has been made in remedying these deficiencies, and both methods have now reached a high level of physical accuracy. Nevertheless, there remains an issue, in that each of these methods has been developed by different research groups, using different codes and most importantly the implementations have been fine tuned to tackle different applications. Thus, it remains unclear what are the remaining advantages and drawbacks of each method relative to the other, and what might be the optimal way to unify them. In this paper, we address this gap by performing a direct comparison of two current state-of-the-art variations of these methods (LS: RCLSFoam and VoF: interPore) and implemented in the same code (OpenFoam). We subject both methods to a pair of benchmark test cases while using the same numerical meshes to examine a) the accuracy of curvature representation, b) the effect of tuning parameters, c) the ability to minimise spurious velocities and d) the ability to tackle fluids with very different densities. For each method, one of the test cases is chosen to be fairly benign while the other test case is expected to present a greater challenge. The results indicate that both methods can be made to work well on both test cases, while displaying different sensitivity to the relevant parameters.

  2. Analysis of two-phase flow inter-subchannel mass and momentum exchanges by the two-fluid model approach

    Energy Technology Data Exchange (ETDEWEB)

    Ninokata, H. [Tokyo Institute of Technology (Japan); Deguchi, A. [ENO Mathematical Analysis, Tokyo (Japan); Kawahara, A. [Kumamoto Univ., Kumamoto (Japan)

    1995-09-01

    A new void drift model for the subchannel analysis method is presented for the thermohydraulics calculation of two-phase flows in rod bundles where the flow model uses a two-fluid formulation for the conservation of mass, momentum and energy. A void drift model is constructed based on the experimental data obtained in a geometrically simple inter-connected two circular channel test sections using air-water as working fluids. The void drift force is assumed to be an origin of void drift velocity components of the two-phase cross-flow in a gap area between two adjacent rods and to overcome the momentum exchanges at the phase interface and wall-fluid interface. This void drift force is implemented in the cross flow momentum equations. Computational results have been successfully compared to experimental data available including 3x3 rod bundle data.

  3. Computer analysis of an adiabatic Stirling cryocooler using a two-phase two-component working fluid

    International Nuclear Information System (INIS)

    Renfroe, D.A.; Cheung, C.M.

    1992-01-01

    This paper describes the performance and behavior of a Stirling cyrocooler incorporating a working fluid composed of helium and nitrogen. At the operating temperature of the cryocooler (80 K), the nitrogen component will condense in the freezer section. It is shown that the phase change in the working fluid increased the heat lifted for a given size and weight of machine and the coefficient of performance. The magnitude of these effects was dependent on the mass ratio of nitrogen to helium, phase angle between the compression and expansion processes, and the ratio of the compression space volume to the expansion space volume. The optimum heat lifted performance was obtained for a mass ratio of four parts of nitrogen to one part of helium, a phase angle of approximately 100 degrees, and a volume ratio of two which resulted in a heat lifted increase of 75% over the single phase, 90 degree phase angle configuration. The coefficient of performance showed a 20% improvement

  4. Influence of the pore fluid on the phase velocity in bovine trabecular bone In Vitro: Prediction of the biot model

    Science.gov (United States)

    Lee, Kang Il

    2013-01-01

    The present study aims to investigate the influence of the pore fluid on the phase velocity in bovine trabecular bone in vitro. The frequency-dependent phase velocity was measured in 20 marrow-filled and water-filled bovine femoral trabecular bone samples. The mean phase velocities at frequencies between 0.6 and 1.2 MHz exhibited significant negative dispersions for both the marrow-filled and the water-filled samples. The magnitudes of the dispersions showed no significant differences between the marrow-filled and the water-filled samples. In contrast, replacement of marrow by water led to a mean increase in the phase velocity of 27 m/s at frequencies from 0.6 to 1.2 MHz. The theoretical phase velocities of the fast wave predicted by using the Biot model for elastic wave propagation in fluid-saturated porous media showed good agreements with the measurements.

  5. Computational fluid dynamics modeling of two-phase flow in a BWR fuel assembly

    International Nuclear Information System (INIS)

    Andrey Ioilev; Maskhud Samigulin; Vasily Ustinenko; Simon Lo; Adrian Tentner

    2005-01-01

    Full text of publication follows: The goal of this project is to develop an advanced Computational Fluid Dynamics (CFD) computer code (CFD-BWR) that allows the detailed analysis of the two-phase flow and heat transfer phenomena in a Boiling Water Reactor (BWR) fuel bundle under various operating conditions. This code will include more fundamental physical models than the current generation of sub-channel codes and advanced numerical algorithms for improved computational accuracy, robustness, and speed. It is highly desirable to understand the detailed two-phase flow phenomena inside a BWR fuel bundle. These phenomena include coolant phase changes and multiple flow regimes which directly influence the coolant interaction with fuel assembly and, ultimately, the reactor performance. Traditionally, the best analysis tools for the analysis of two-phase flow phenomena inside the BWR fuel assembly have been the sub-channel codes. However, the resolution of these codes is still too coarse for analyzing the detailed intra-assembly flow patterns, such as flow around a spacer element. Recent progress in Computational Fluid Dynamics (CFD), coupled with the rapidly increasing computational power of massively parallel computers, shows promising potential for the fine-mesh, detailed simulation of fuel assembly two-phase flow phenomena. However, the phenomenological models available in the commercial CFD programs are not as advanced as those currently being used in the sub-channel codes used in the nuclear industry. In particular, there are no models currently available which are able to reliably predict the nature of the flow regimes, and use the appropriate sub-models for those flow regimes. The CFD-BWR code is being developed as a customized module built on the foundation of the commercial CFD Code STAR-CD which provides general two-phase flow modeling capabilities. The paper describes the model development strategy which has been adopted by the development team for the

  6. A Two-Phase Flow Solver for Incompressible Viscous Fluids, Using a Pure Streamfunction Formulation and the Volume of Fluid Technique

    DEFF Research Database (Denmark)

    Comminal, Raphaël; Spangenberg, Jon; Hattel, Jesper Henri

    Accurate multi-phase flow solvers at low Reynolds number are of particular interest for the simulation of interface instabilities in the co-processing of multilayered material. We present a two-phase flow solver for incompressible viscous fluids which uses the streamfunction as the primary variable...... of the flow. Contrary to fractional step methods, the streamfunction formulation eliminates the pressure unknowns, and automatically fulfills the incompressibility constraint by construction. As a result, the method circumvents the loss of temporal accuracy at low Reynolds numbers. The interface is tracked...

  7. A Two-Phase Flow Solver for Incompressible Viscous Fluids, Using a Pure Streamfunction Formulation and the Volume of Fluid Technique

    DEFF Research Database (Denmark)

    Comminal, Raphaël; Spangenberg, Jon; Hattel, Jesper Henri

    2014-01-01

    Accurate multi-phase flow solvers at low Reynolds number are of particular interest for the simulation of interface instabilities in the co-processing of multilayered material. We present a two-phase flow solver for incompressible viscous fluids which uses the streamfunction as the primary variable...... of the flow. Contrary to fractional step methods, the streamfunction formulation eliminates the pressure unknowns, and automatically fulfills the incompressibility constraint by construction. As a result, the method circumvents the loss of temporal accuracy at low Reynolds numbers. The interface is tracked...

  8. Dynamics of mineral crystallization from precipitated slab-derived fluid phase: first in situ synchrotron X-ray measurements

    Science.gov (United States)

    Malaspina, Nadia; Alvaro, Matteo; Campione, Marcello; Wilhelm, Heribert; Nestola, Fabrizio

    2015-03-01

    Remnants of the fluid phase at ultrahigh pressure (UHP) in subduction environments may be preserved as primary multiphase inclusions in UHP minerals. The mode of crystallization of daughter minerals during precipitation within the inclusion and/or the mechanism of interaction between the fluid at supercritical conditions and the host mineral are still poorly understood from a crystallographic point of view. A case study is represented by garnet-orthopyroxenites from the Maowu Ultramafic Complex (China) deriving from harzburgite precursors metasomatized at ~4 GPa, 750 °C by a silica- and incompatible trace element-rich fluid phase. This metasomatism produced poikilitic orthopyroxene and inclusion-rich garnet porphyroblasts. Solid multiphase primary inclusions in garnet display a size within a few tens of micrometres and negative crystal shapes. Infilling minerals (spinel: 10-20 vol%; amphibole, chlorite, talc, mica: 80-90 vol%) occur with constant volume proportions and derive from trapped solute-rich aqueous fluids. To constrain the possible mode of precipitation of daughter minerals, we performed for the first time a single-crystal X-ray diffraction experiment by synchrotron radiation at Diamond Light Source. In combination with electron probe microanalyses, this measurement allowed the unique identification of each mineral phase and reciprocal orientations. We demonstrated the epitaxial relationship between spinel and garnet and between some hydrous minerals. Such information is discussed in relation to the physico-chemical aspects of nucleation and growth, shedding light on the mode of mineral crystallization from a fluid phase trapped at supercritical conditions.

  9. Design of a Subscale Propellant Slag Evaluation Motor Using Two-Phase Fluid Dynamic Analysis

    Science.gov (United States)

    Whitesides, R. Harold; Dill, Richard A.; Purinton, David C.; Sambamurthi, Jay K.

    1996-01-01

    Small pressure perturbations in the Space Shuttle Reusable Solid Rocket Motor (RSRM) are caused by the periodic expulsion of molten aluminum oxide slag from a pool that collects in the aft end of the motor around the submerged nozzle nose during the last half of motor operation. It is suspected that some motors produce more slag than others due to differences in aluminum oxide agglomerate particle sizes that may relate to subtle differences in propellant ingredient characteristics such as particle size distributions or processing variations. A subscale motor experiment was designed to determine the effect of propellant ingredient characteristics on the propensity for slag production. An existing 5 inch ballistic test motor was selected as the basic test vehicle. The standard converging/diverging nozzle was replaced with a submerged nose nozzle design to provide a positive trap for the slag that would increase the measured slag weights. Two-phase fluid dynamic analyses were performed to develop a nozzle nose design that maintained similitude in major flow field features with the full scale RSRM. The 5 inch motor was spun about its longitudinal axis to further enhance slag collection and retention. Two-phase flow analysis was used to select an appropriate spin rate along with other considerations, such as avoiding bum rate increases due to radial acceleration effects. Aluminum oxide particle distributions used in the flow analyses were measured in a quench bomb for RSRM type propellants with minor variations in ingredient characteristics. Detailed predictions for slag accumulation weights during motor bum compared favorably with slag weight data taken from defined zones in the subscale motor and nozzle. The use of two-phase flow analysis proved successful in gauging the viability of the experimental program during the planning phase and in guiding the design of the critical submerged nose nozzle.

  10. Effects of solid/liquid phase fractionation on pH and aqueous species molality in subduction zone fluids

    Science.gov (United States)

    Zhong, X.; Galvez, M. E.

    2017-12-01

    Metamorphic fluids are a crucial ingredient of geodynamic evolution, i.e. heat transfer, rock mechanics and metamorphic/metasomatic reactions. During crustal evolution at elevated P and T, rock forming components can be effectively fractionated from the reactive rock system by at least two processes: 1. extraction from porous rocks by liquid phases such as solute-bearing (e.g. Na+, Mg2+) aqueous fluids or partial melts. 2. isolation from effective bulk rock composition due to slow intragranular diffusion in high-P refractory phases such as garnet. The effect of phase fractionation (garnet, partial melt and aqueous species) on fluid - rock composition and properties remain unclear, mainly due to a high demand in quantitative computations of the thermodynamic interactions between rocks and fluids over a wide P-T range. To investigate this problem, we build our work on an approach initially introduced by Galvez et al., (2015) with new functionalities added in a MATLAB code (Rubisco). The fluxes of fractionated components in fluid, melt and garnet are monitored along a typical prograde P-T path for a model crustal pelite. Some preliminary results suggest a marginal effect of fractionated aqueous species on fluid and rock properties (e.g. pH, composition), but the corresponding fluxes are significant in the context of mantle wedge metasomatism. Our work provides insight into the role of high-P phase fractionation on mass redistribution between the surface and deep Earth in subduction zones. Existing limitations relevant to our liquid/mineral speciation/fractionation model will be discussed as well. ReferencesGalvez, M.E., Manning, C.E., Connolly, J.A.D., Rumble, D., 2015. The solubility of rocks in metamorphic fluids: A model for rock-dominated conditions to upper mantle pressure and temperature. Earth Planet. Sci. Lett. 430, 486-498.

  11. Some numerical methods for two-fluid two-phase flows in oil pipes; Quelques methodes numeriques pour les ecoulements diphasiques bi-fluide en conduites petrolieres

    Energy Technology Data Exchange (ETDEWEB)

    Masella, J.M.

    1997-05-29

    This thesis is devoted to the numerical simulation of some two-fluid models describing gas-liquid two-phase flow in pipes. The numerical models developed here can be more generally used in the modelling of a wide class of physical models which can be put under an hyperbolic form. We introduce first two isothermal two-fluid models, composed of a mass balance equation and a momentum equation written in each phase, describing respectively a stratified two-phase flow and a dispersed two-phase flow. These models are hyperbolic under some physical assumptions and can be written under a nonconservative vectorial system. We define and analyse a new numerical finite volume scheme (v{integral}Roe) founded on a linearized Riemann solver. This scheme does not need any analytical calculation and gives good results in the tracking of shocks. We compare this new scheme with the classical Roe scheme. Then we propose and study some numerical models, with and without flux splitting method, which are adapted to the discretization of the two-fluid models. This numerical models are given by a finite volume integration of the equations, and lean on the v{integral} scheme. In order to reducing cpu time, due to the low Mach number of two-phase flows, acoustic waves are implicit. Afterwards we proposed a discretization of boundary conditions, which allows the generation of transient flows in pipe. Some numerical academic and more physical tests show the good behaviour of the numerical methods. (author) 77 refs.

  12. Implicit approximate Riemann solver for two fluid two phase flow models

    International Nuclear Information System (INIS)

    Raymond, P.; Toumi, I.; Kumbaro, A.

    1993-01-01

    This paper is devoted to the description of new numerical methods developed for the numerical treatment of two phase flow models with two velocity fields which are now widely used in nuclear engineering for design or safety calculations. These methods are finite volumes numerical methods and are based on the use of Approximate Riemann Solver's concepts in order to define convective flux versus mean cell quantities. The first part of the communication will describe the numerical method for a three dimensional drift flux model and the extensions which were performed to make the numerical scheme implicit and to have fast running calculations of steady states. Such a scheme is now implemented in the FLICA-4 computer code devoted to 3-D steady state and transient core computations. We will present results obtained for a steady state flow with rod bow effect evaluation and for a Steam Line Break calculation were the 3-D core thermal computation was coupled with a 3-D kinetic calculation and a thermal-hydraulic transient calculation for the four loops of a Pressurized Water Reactor. The second part of the paper will detail the development of an equivalent numerical method based on an approximate Riemann Solver for a two fluid model with two momentum balance equations for the liquid and the gas phases. The main difficulty for these models is due to the existence of differential modelling terms such as added mass effects or interfacial pressure terms which make hyperbolic the model. These terms does not permit to write the balance equations system in a conservative form, and the classical theory for discontinuity propagation for non-linear systems cannot be applied. Meanwhile, the use of non-conservative products theory allows the study of discontinuity propagation for a non conservative model and this will permit the construction of a numerical scheme for two fluid two phase flow model. These different points will be detailed in that section which will be illustrated by

  13. Self-Assembling, Stable Photonic Bend-Gap Phases in Emulsions of Chiral Nematics with Isotropic Fluids

    Science.gov (United States)

    Huang, Chien-Yueh; Petschek, R. G.

    1998-03-01

    We investigate the possible mesophases in emulsions of chiral nematic liquid crystals with immiscible isotropic fluids and surfactants. The interactions between the orientational fields of the chiral nematics and the surfactant membranes together with the topological constraints affect stability of micellar geometries and produce a new phase diagram. We compare the free energies of various candidate phases. Appropriate, likely realizable conditions on the surfactant and the pitch of the liquid crystal result in thermodynamically stable blue-phase like phases for a relatively wide range of parameters. Processing such emulsions may result in materials with photonic band gaps.

  14. Theory for added mass of a vibrating circular rod in a two-phase air-water fluid

    International Nuclear Information System (INIS)

    Kohgo, Osamu; Hara, Fumio

    1985-01-01

    It has been well known that there are added mass and attenuation effect due to surrounding fluid in a structure vibrating in the fluid, and those are different according to the density and viscosity of the fluid and the form of the structure. In this study, in order to clarify added mass, the model of the vapor-liquid two-phase fluid with discontinuous density distribution was made. That is, bubbles were assumed to be a bubble column without bending stiffness and mass, and potential analysis was applied to a two-dimensional fluid field composed of a round section beam and the bubble column, thus their relative motion was hydrodynamically analyzed, and the theory for evaluating added mass was developed. The added mass experimentally determined from the response gain of a single round section cantilever when it was oscillated steadily, uniformly and at random in the vapor-liquid two-phase fluid being stationary as a whole and the theoretical result were examined by comparison, and equivalent bubble diameter was considered, thereafter, the validity of the model was examined. (Kako, I.)

  15. Interface model coupling in fluid dynamics: application to two-phase flows

    International Nuclear Information System (INIS)

    Galie, Th.

    2009-03-01

    This thesis is devoted to the study of interface model coupling problems in space between different models of compressible flows. We consider one-dimensional problems where the interface is sharp, fixed and separating two regions of space corresponding to the two coupled models. Our goal is to define a coupling condition at the interface and to solve numerically the coupling problem with this condition. After a state of art on the interface model coupling of hyperbolic systems of conservation laws, we propose a new coupling condition by adding in the equations of the coupled problem a measure source term at the interface. We first suppose a given constant weight associated to this source term. Two Riemann solvers are developed and one of them is based on a relaxation approach preserving equilibrium solutions of the coupled problem. This relaxation method is then used in an optimization problem, defined by several motivations at the interface, which permits to calculate a time dynamical weight. In a second part, we develop an approached Riemann solver for a two-phase two-pressure model in the particular case of a two-phase isentropic flow. Such a model contains non conservative terms that we write under the form of measure source terms. The previous relaxation method is thus extended to the case of the two-phase two-pressure model with an a priori estimation of the non conservative term contributions. The method allows us to solve, in the next and last chapter, the coupling problem of a two-fluid two-pressure model with a drift-flux model thanks to the father model approach. (authors)

  16. Quantitative measurement of normal and hydrocephalic cerebrospinal fluid flow using phase contrast cine MR imaging

    International Nuclear Information System (INIS)

    Katayama, Shinji; Asari, Shoji; Ohmoto, Takashi

    1993-01-01

    Measurements of the cerebrospinal fluid (CSF) flow using phase contrast cine magnetic resonance (MR) imaging were performed on a phantom, 12 normal subjects and 20 patients with normal pressure hydrocephalus (NPH). The phantom study demonstrated the applicability of phase contrast in quantitative measurement of the slow flow. The CSF flows of the normal subjects showed a consistent pattern with a to-and-fro movement of the flow in the anterior subarachnoid space at the C2/3 level, and they were dependent on the cardiac cycle in all subjects. However, the patients with NPH showed variable patterns of the CSF pulsatile flow and these patterns could be divided into four types according to velocity and amplitude. The amplitudes of each type were as follows: type 0 (n=1), 87.6 mm; type I (n=2), 58.2 mm (mean); type II (n=6), 48.0±5.0 mm (mean±SEM); and type III (n=11), 19.9±1.8 mm (mean±SEM). The decrease of the amplitudes correlated to a worsening of the clinical symptoms. After the shunting operation, the amplitude of to-and-fro movement of the CSF increased again in the patients with NPH who improved clinically. Some of the type III cases were reclassified type II, I and 0 and also one of the type II cases changed type I after the shunting operation. We conclude that the phase contrast cine MR imaging is a practically and clinically applicable technique for the quantitative measurement of the CSF flow. (author)

  17. Determination and theoretical analysis of supercritical fluid chromatographic retention of polycyclic aromatic hydrocarbons in a polymeric smectic phase

    International Nuclear Information System (INIS)

    Chao Yan; Martire, D.E.

    1992-01-01

    A mean-field lattice model is used to describe the partitioning of blocklike molecules between an isotropic mobile phase and an anisotropic stationary phase in chromatography by applying it to supercritical fluid retention of polycyclic aromatic hydrocarbons in a polymeric smectic phase. This concludes that the logarithm of the capacity factor (1) increases linearly with increasing reciprocal temperature, (2) decreases with increasing mobile phase density more rapidly for solute molecules with a relatively larger contact area with the mobile phase, and (3) is a linear function of the minimum area. The van't Hoff plot slope is also determined to be more negative for solute molecules with a relatively larger ratio of contact area with the stationary phase versus the mobile phase. 18 refs., 9 figs., 5 tabs

  18. Binding of monoclonal antibody to protein antigen in fluid phase or bound to solid supports

    Energy Technology Data Exchange (ETDEWEB)

    Kennel, S J

    1982-01-01

    Rat monoclonal antibody (MoAb) to fragment D (FgD) of human fibrinogen was used to characterize the direct binding of antibody to protein in solution or bound to solid supports. Purified IgG, F(ab')/sub 2/ and Fab' were prepared from ascites fluid of hybridoma 104-14B which is a fusion product of spleen cells from a rat immunized with FgD and the mouse myeloma cell line, P3-X63-Ag8. Two-dimensional electrophoresis of radioiodinated antibody preparations demonstrated the presence of hybrid immunoglobulin molecules, but only structures having rat heavy and rat light chains had active antibody combinig sites. The affinity constant for IgG as well as F(ab')/sub 2/ and Fab', 6x10/sup 9/ M/sup -1/, was identical when tested using fluid phase antigen (/sup 125/I-labeled FgD). Affinity constants determined for direct binding of iodinated IgG using FgD immobilized on solid supports showed a slight dependence on the antigen concentration used in the measurement. These values ranged from 0.5x10/sup 9/ M/sup -1/ at high antigen concentrations (1.3x10/sup -7/ M) to 9x10/sup 9/ M/sup -1/ at low antigen concentration (1.3x10/sup -10/ M). Binding constants for F(ab')/sub 2/ and Fab' gave similar results indicating that binding was homogeneous and univalent. The capacity of solid state antigen to bind antibody varied with the method used to bind FgD to the solid support. FgD bound directly to polystyrene plates was least efficient at binding labeled antibody; FgD bound to plates through intermediate carriers poly(L-lysine) was only slightly more efficient, while antigen bound to Sepharose beads by cyanogen bromide activation was the most active.

  19. Effect of intra-membrane C60 fullerenes on the modulus of elasticity and the mechanical resistance of gel and fluid lipid bilayers

    Science.gov (United States)

    Zhou, Jihan; Liang, Dehai; Contera, Sonia

    2015-10-01

    Penetration and partition of C60 to the lipid bilayer core are both relevant to C60 toxicity, and useful to realise C60 biomedical potential. A key aspect is the effect of C60 on bilayer mechanical properties. Here, we present an experimental study on the mechanical effect of the incorporation of C60 into the hydrophobic core of fluid and gel phase zwitterionic phosphatidylcholine (PC) lipid bilayers. We demonstrate its incorporation inside the hydrophobic lipid core and the effect on the packing of the lipids and the vesicle size using a combination of infrared (IR) spectroscopy, atomic force microscopy (AFM) and laser light scattering. Using AFM we measured the Young's modulus of elasticity (E) of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) in the absence (presence) of intra-membranous C60 at 24.5 °C. E of fluid phase supported bilayers is not altered by C60, but E increases with incorporation of C60 in gel phase bilayers. The increase is higher for longer hydrocarbon chains: 1.6 times for DPPC and 2 times for DSPC. However the mechanical resistance of gel phase bilayers of curved bilayered structures decreases with the incorporation of C60. Our combined results indicate that C60 causes a decrease in gel phase lipid mobility, i.e. an increase in membrane viscosity.

  20. Can macular xanthophylls replace cholesterol in formation of the liquid-ordered phase in lipid-bilayer membranes?

    Science.gov (United States)

    Subczynski, Witold K; Wisniewska-Becker, Anna; Widomska, Justyna

    2012-01-01

    Lateral organization of membranes made from binary mixtures of dimyristoylphosphatidylcholine (DMPC) or dipalmitoylphosphatidylcholine (DPPC) and macular xanthophylls (lutein or zeaxanthin) was investigated using the saturation-recovery (SR) EPR spin-labeling discrimination by oxygen transport (DOT) method in which the bimolecular collision rate of molecular oxygen with the nitroxide spin label is measured. This work was undertaken to examine whether or not lutein and zeaxanthin, macular xanthophylls that parallel cholesterol in its function as a regulator of both membrane fluidity and hydrophobicity, can parallel other structural functions of cholesterol, including formation of the liquid-ordered phase in membranes. The DOT method permits discrimination of different membrane phases when the collision rates (oxygen transport parameter) differ in these phases. Additionally, membrane phases can be characterized by the oxygen transport parameter in situ without the need for separation, which provides information about the dynamics of each phase. In gel-phase membranes, two coexisting phases were discriminated in the presence of macular xanthophylls - namely, the liquid-ordered-like and solid-ordered-like phases. However, in fluid-phase membranes, xanthophylls only induce the solitary liquid-ordered-like phase, while at similar concentrations, cholesterol induces coexisting liquid-ordered and liquid-disordered phases. No significant differences between the effects of lutein and zeaxanthin were found.

  1. A numerical model of two-phase flow at the micro-scale using the volume-of-fluid method

    Science.gov (United States)

    Shams, Mosayeb; Raeini, Ali Q.; Blunt, Martin J.; Bijeljic, Branko

    2018-03-01

    This study presents a simple and robust numerical scheme to model two-phase flow in porous media where capillary forces dominate over viscous effects. The volume-of-fluid method is employed to capture the fluid-fluid interface whose dynamics is explicitly described based on a finite volume discretization of the Navier-Stokes equations. Interfacial forces are calculated directly on reconstructed interface elements such that the total curvature is preserved. The computed interfacial forces are explicitly added to the Navier-Stokes equations using a sharp formulation which effectively eliminates spurious currents. The stability and accuracy of the implemented scheme is validated on several two- and three-dimensional test cases, which indicate the capability of the method to model two-phase flow processes at the micro-scale. In particular we show how the co-current flow of two viscous fluids leads to greatly enhanced flow conductance for the wetting phase in corners of the pore space, compared to a case where the non-wetting phase is an inviscid gas.

  2. Modeling Temperature Development of Li-ion Battery Packs using Phase Change Materials (PCM) and Fluid Flow

    DEFF Research Database (Denmark)

    Coman, Paul Tiberiu; Veje, Christian

    2014-01-01

    This paper presents a dynamic model for simulating the heat generation and the impact of Phase Change Materials (PCMs) on the maximum temperature in LiFePO4 battery cells. The model is constructed by coupling a one-dimensional electro-chemical model with a two-dimensional thermal model and fluid...

  3. Debris transport evaluation during the blow-down phase of a LOCA using computational fluid dynamics

    International Nuclear Information System (INIS)

    Park, Jong Pil; Jeong, Ji Hwan; Kim, Won Tae; Kim, Man Woong; Park, Ju Yeop

    2011-01-01

    Highlights: → We conducted CFD simulation on the spreading of the coolant in the containment after a break of the hot leg. It is used to estimate the dispersion of the debris within the containment. → It was assumed that the small and fine debris is transported by the discharge flow so that a fraction of the small and fine debris transport can be estimated based on the amount of water. → The break flow was assumed to be a homogeneous two-phase mixture without phase separation. Isenthalpic expansion of the break flow was used to specify the inlet boundary condition of the break flow. → The fraction of the small and fine debris transported to the upper part is 73%; this value is close to the value calculated using 1D lumped-parameter codes by the USNRC and the KINS, respectively, while 48% more than the value shown in the NEI 04-07. - Abstract: The performance of the emergency recirculation water sump under the influence of debris accumulation following a loss-of-coolant accident (LOCA) has long been of safety concern. Debris generation and transport during a LOCA are significantly influenced by the characteristics of the ejected coolant flow. One-dimensional analyses previously have been attempted to evaluate the debris transport during the blow-down phase but the transport evaluation still has large uncertainties. In this work, a computational fluid dynamics (CFD) analysis was utilized to evaluate small and fine debris transport during the blow-down phase of a pressurized water reactor, OPR1000. The coolant ejected from the ruptured hot-leg was assumed to expand in an isenthalpic process. The transport of small and fine debris was assumed to be dominated by water-borne transport, and the transport fractions for the upper and lower parts of the containment were quantified based on the CFD analysis. It was estimated that 73% of small and fine debris is transported to the upper part of the containment. This value is close to the values estimated by nuclear

  4. Molecular theory of chromatography for blocklike solutes in isotropic stationary phases and its application to supercritical fluid chromatographic retention of PAHs

    International Nuclear Information System (INIS)

    Chao Yan; Martire, D.E.

    1992-01-01

    This report discusses a molecular theory of chromatography for blocklike solutes in isotropic stationary phases as an extension to the anisotopic phase approach. Its it applied to gas, liquid, and supercritical fluid chromatography

  5. Structural steady states and relaxation oscillations in a two-phase fluid under shear flow: Experiments and phenomenological model

    Science.gov (United States)

    Courbin, L.; Benayad, A.; Panizza, P.

    2006-01-01

    By means of several rheophysics techniques, we report on an extensive study of the couplings between flow and microstructures in a two-phase fluid made of lamellar (Lα) and sponge (L3) phases. Depending on the nature of the imposed dynamical parameter (stress or shear rate) and on the experimental conditions (brine salinity or temperature), we observe several different structural steady states consisting of either multilamellar droplets (with or without a long range order) or elongated (L3) phase domains. Two different astonishing phenomena, shear-induced phase inversion and relaxation oscillations, are observed. We show that (i) phase inversion is related to a shear-induced topological change between monodisperse multilamellar droplets and elongated structures and (ii) droplet size relaxation oscillations result from a shear-induced change of the surface tension between both coexisting (Lα) and (L3) phases. To explain these relaxation oscillations, we present a phenomenological model and compare its numerical predictions to our experimental results.

  6. Qualitative and quantitative analysis of different fluid phase in samples of glass beads by X-ray microtomography

    International Nuclear Information System (INIS)

    Marques, Leonardo C.; Nagata, Rodrigo; Appoloni, Carlos R.; Moreira, Anderson C.; Fernanades, Celso P.

    2011-01-01

    The X-ray microtomography has showed to be a useful tool for studies of inner structure of reservoir rocks. Moreover recent works have used this methodology to visualize different fluid phases present in these microstructures. In this paper X-ray microtomography has been applied to visualize three fluid phases, separately or simultaneously, in addition to a solid phase (glass beads). Two glass beads samples were manufactured and scanned, one with 0.8 mm (GB1) and other with 0.6 mm (GB2) diameter, respectively. The three fluid phases used were air, oil and a water-salt-potassium iodine solution. Two Skyscan scanners were used, both a 1172 model, which employs X-ray tube with W anode and cone beam. This laboratory based equipment is able to provide images of until 1 μm spatial resolution. One microtomograph is located at CENPES/PETROBRAS and has a CCD camera of 10 mega pixels resolution. It was used to measure the GB1 sample at 4.84 μm spatial resolution. The other one is located at LAMIR/UFPR and has a CCD camera of 11 mega pixels resolution. It was used to measure the GB2 sample at 4.99 μm spatial resolution. GB1 sample was set up with three fluid phases and presented 38.0 (2.7) % of total porosity before fluid presence and 3.5 % and 19.8 %, as lower and higher average porosity values, respectively, after to be filled with them. GB2 sample was set up with oil and water-salt-potassium iodine solution separated. It presented 36.7 (1.9) % of total porosity when dried, 18.7 (2.0) % when filled with oil and 0 % when filled with the solution. The 2D images clearly show the presence of the solution in addition to the air and solid phases. They also show that the presence of oil phase is less clear than the solution. When all the phases are present together in the sample it is possible to differentiate all of them. Individual 3D images are shown for each phase present in the sample. The 3D image containing all the phases is also shown. (author)

  7. Simulating single-phase and two-phase non-Newtonian fluid flow of a digital rock scanned at high resolution

    Science.gov (United States)

    Tembely, Moussa; Alsumaiti, Ali M.; Jouini, Mohamed S.; Rahimov, Khurshed; Dolatabadi, Ali

    2017-11-01

    Most of the digital rock physics (DRP) simulations focus on Newtonian fluids and overlook the detailed description of rock-fluid interaction. A better understanding of multiphase non-Newtonian fluid flow at pore-scale is crucial for optimizing enhanced oil recovery (EOR). The Darcy scale properties of reservoir rocks such as the capillary pressure curves and the relative permeability are controlled by the pore-scale behavior of the multiphase flow. In the present work, a volume of fluid (VOF) method coupled with an adaptive meshing technique is used to perform the pore-scale simulation on a 3D X-ray micro-tomography (CT) images of rock samples. The numerical model is based on the resolution of the Navier-Stokes equations along with a phase fraction equation incorporating the dynamics contact model. The simulations of a single phase flow for the absolute permeability showed a good agreement with the literature benchmark. Subsequently, the code is used to simulate a two-phase flow consisting of a polymer solution, displaying a shear-thinning power law viscosity. The simulations enable to access the impact of the consistency factor (K), the behavior index (n), along with the two contact angles (advancing and receding) on the relative permeability.

  8. An Overview of SBIR Phase 2 In-Space Propulsion and Cryogenic Fluids Management

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2015-01-01

    Technological innovation is the overall focus of NASA's Small Business Innovation Research (SBIR) program. The program invests in the development of innovative concepts and technologies to help NASA's mission directorates address critical research and development needs for agency projects. This report highlights innovative SBIR Phase II projects from 2007-2012 specifically addressing Areas in In-Space Propulsion and Cryogenic Fluids Management which is one of six core competencies at NASA Glenn Research Center. There are nineteen technologies featured with emphasis on a wide spectrum of applications such as high-performance Hall thruster support system, thruster discharge power converter, high-performance combustion chamber, ion thruster design tool, green liquid monopropellant thruster, and much more. Each article in this booklet describes an innovation, technical objective, and highlights NASA commercial and industrial applications. This report serves as an opportunity for NASA personnel including engineers, researchers, and program managers to learn of NASA SBIR's capabilities that might be crosscutting into this technology area. As the result, it would cause collaborations and partnerships between the small companies and NASA Programs and Projects resulting in benefit to both SBIR companies and NASA.

  9. Centrifuge - dewatering of oil sand fluid tailings: phase 2 field-scale test

    Energy Technology Data Exchange (ETDEWEB)

    Seto, Jack T.C. [BGC Engineering Inc (Canada); O' Kane, Mike [O' Kane Consultants Inc (Canada); Donahue, Robert [Applied Geochemical Solutions Engineering (Canada); Lahaie, Rick [Syncrude Canada Ltd (Canada)

    2011-07-01

    In order to reduce the accumulation of oil sand fluid fine tailings (FFT) and to create trafficable surfaces for reclamation, Syncrude Canada Ltd. has been studying several tailings technologies. Centrifuge-dewatering is one such technology. This paper discusses the phase 2 field-scale tests for centrifuge-dewatering of oil sand FFT. In centrifuge-dewatering, FFT is diluted and treated with flocculant, then processed through a centrifuge plant and the high-density underflow is transported to a tailings deposit. This technology has evolved since 2005 from laboratory bench scale tests. More than 10,000 cubic meters of centrifuge cake was treated, produced and transported to ten different deposits over a 12-week period from August to October 2010. The amount of solids in FFT was increased from 30% to 50% by centrifuging. Sampled deposits were tested and instrumented for in situ strength. It can be concluded that the deposits can be strengthened and densified by natural dewatering processes like freeze-thaw action and evaporative drying.

  10. Theoretical and numerical investigations of inverse patchy colloids in the fluid phase

    International Nuclear Information System (INIS)

    Kalyuzhnyi, Yurij V.; Bianchi, Emanuela; Ferrari, Silvano; Kahl, Gerhard

    2015-01-01

    We investigate the structural and thermodynamic properties of a new class of patchy colloids, referred to as inverse patchy colloids (IPCs) in their fluid phase via both theoretical methods and simulations. IPCs are nano- or micro- meter sized particles with differently charged surface regions. We extend conventional integral equation schemes to this particular class of systems: our approach is based on the so-called multi-density Ornstein-Zernike equation, supplemented with the associative Percus-Yevick approximation (APY). To validate the accuracy of our framework, we compare the obtained results with data extracted from NpT and NVT Monte Carlo simulations. In addition, other theoretical approaches are used to calculate the properties of the system: the reference hypernetted-chain (RHNC) method and the Barker-Henderson thermodynamic perturbation theory. Both APY and RHNC frameworks provide accurate predictions for the pair distribution functions: APY results are in slightly better agreement with MC data, in particular at lower temperatures where the RHNC solution does not converge

  11. Improved solid-phase extraction method for systematic toxicological analysis in biological fluids.

    Science.gov (United States)

    Soriano, T; Jurado, C; Menéndez, M; Repetto, M

    2001-03-01

    A method for the simultaneous qualitative and quantitative determination of drugs of abuse (opiates, cocaine, or amphetamines) and prescribed drugs (tricyclic antidepressants, phenotiazines, benzodiazepines, etc.) in biological fluids--blood, urine, bile, and gastric contents--was developed. This procedure involves solid-phase extraction with Bond-Elut Certify columns followed by analysis by gas chromatography-nitrogen-phosphorus detection (GC-NPD) and confirmation by gas chromatography-mass spectrometry (GC-MS), after derivatization, when necessary. Pretreatment was performed on all samples: sonication for 15 min plus enzymatic hydrolysis with beta-glucuronidase in urine. With respect to the internal standards, nalorphine and trihexylamine were used for basic substances, allobarbital for acidic drugs, and prazepam for benzodiazepines. Acidic and basic compounds were extracted from different aliquots of samples at different pH levels: 6-6.5 for the acidic and neutral and 8-8.5 for the basic and the benzodiazepines. Several areas of experimental design were considered in the process of method optimization. These included internal standards, pH, sonication, flow rate and washing solvents. It was found that systematic analysis could be reliably performed using optimized extraction conditions. The recovery rates for the compounds tested were always higher than 61.02%.

  12. Fluid Phase Lipid Areas and Bilayer Thicknesses of Commonly Used Phosphatidylcholines as a Function of Temperature

    International Nuclear Information System (INIS)

    Kucerka, Norbert; Nieh, Mu-Ping; Katsaras, John

    2011-01-01

    The structural parameters of fluid phase bilayers composed of phosphatidylcholines with fully saturated, mixed, and branched fatty acid chains, at several temperatures, have been determined by simultaneously analyzing small-angle neutron and X-ray scattering data. Bilayer parameters, such as area per lipid and overall bilayer thickness have been obtained in conjunction with intrabilayer structural parameters (e.g. hydrocarbon region thickness). The results have allowed us to assess the effect of temperature and hydrocarbon chain composition on bilayer structure. For example, we found that for all lipids there is, not surprisingly, an increase in fatty acid chain trans-gauche isomerization with increasing temperature. Moreover, this increase in trans-gauche isomerization scales with fatty acid chain length in mixed chain lipids. However, in the case of lipids with saturated fatty acid chains, trans-gauche isomerization is increasingly tempered by attractive chain-chain van der Waals interactions with increasing chain length. Finally, our results confirm a strong dependence of lipid chain dynamics as a function of double bond position along fatty acid chains.

  13. Increased levels of proteins of the acute inflammatory phase in the peritoneal fluid of women with advanced stages of endometriosis.

    Science.gov (United States)

    Polak, Grzegorz; Barczyński, Bartłomiej; Bednarek, Wiesława; Kwaśniewski, Wojciech; Wertell, Iwona; Derewianka-Polak, Magdalena; Makara-Studzińska, Marta; Kotarski, Jan

    2015-06-01

    Most investigators agree that endometriosis is associated with a state of subclinical, non-infectious peritoneal inflammation. The objective of the study was to assess concentrations of two markers of the acute inflammatory phase proteins, haptoglobin and ceruloplasmin, in peritoneal fluid of endometriotic women. 229 women who underwent diagnostic or therapeutic laparoscopy were included in the study Minimal, mild, moderate and severe endometriosis according to ASRM was confirmed in 119 women (study groups), whereas 110 patients suffered from simple serous or dermoid ovarian cysts (reference groups). Haptoglobin and ceruloplasmin concentrations in the peritoneal fluid samples aspirated during laparoscopy were measured using commercially available radial immunodiffusion kits. The concentration of haptoglobin in the peritoneal fluid of women with endometriosis was significantly higher as compared to patients with serous and dermoid ovarian cysts. Significantly higher haptoglobin level was observed in patients with severe and moderate endometriosis as compared to women from both reference groups. No significant difference in the peritoneal fluid ceruloplasmin levels was found between patients with endometriosis and women from reference groups. However, it was noted that ceruloplasmin levels are higher in the subgroup of patients with severe endometriosis as compared to both reference groups and women with mild disease. Our results support the hypothesis that endometriosis is associated with subclinical inflammation within the peritoneal cavity It may be speculated that pro-inflammatory stimuli strong enough to cause an increase in acute inflammatory phase proteins peritoneal fluid concentrations are observed only in the advanced stages of the disease.

  14. A Gas-Kinetic Method for Hyperbolic-Elliptic Equations and Its Application in Two-Phase Fluid Flow

    Science.gov (United States)

    Xu, Kun

    1999-01-01

    A gas-kinetic method for the hyperbolic-elliptic equations is presented in this paper. In the mixed type system, the co-existence and the phase transition between liquid and gas are described by the van der Waals-type equation of state (EOS). Due to the unstable mechanism for a fluid in the elliptic region, interface between the liquid and gas can be kept sharp through the condensation and evaporation process to remove the "averaged" numerical fluid away from the elliptic region, and the interface thickness depends on the numerical diffusion and stiffness of the phase change. A few examples are presented in this paper for both phase transition and multifluid interface problems.

  15. Thermal regulation in terrestrial environment using a two-phase fluid loop with capillary pumping; Regulation thermique en environnement terrestre par boucle fluide diphasique a pompage capillaire

    Energy Technology Data Exchange (ETDEWEB)

    Butto, C [Universite Paul Sabatier, LESETH, 31 - Toulouse (France)

    1997-12-31

    Two-phase fluid loops with capillary pumping are particularly interesting silent devices which allow energy savings and do not create any noise pollution (no mechanical vibrations). In terrestrial environment, the gravity field, when judiciously used, allows to improve their performances and thus, their use in thermal regulation of big computers, power electronic components, transformers, etc, is particularly interesting. In this study, the main results concerning the functioning of such a loop in the gravity field are presented and used to highlight the conditions that allow to take advantage of this field and the improvements obtained. (J.S.) 5 refs.

  16. Thermal regulation in terrestrial environment using a two-phase fluid loop with capillary pumping; Regulation thermique en environnement terrestre par boucle fluide diphasique a pompage capillaire

    Energy Technology Data Exchange (ETDEWEB)

    Butto, C. [Universite Paul Sabatier, LESETH, 31 - Toulouse (France)

    1996-12-31

    Two-phase fluid loops with capillary pumping are particularly interesting silent devices which allow energy savings and do not create any noise pollution (no mechanical vibrations). In terrestrial environment, the gravity field, when judiciously used, allows to improve their performances and thus, their use in thermal regulation of big computers, power electronic components, transformers, etc, is particularly interesting. In this study, the main results concerning the functioning of such a loop in the gravity field are presented and used to highlight the conditions that allow to take advantage of this field and the improvements obtained. (J.S.) 5 refs.

  17. Fluid-elastic Instability of Helical Tubes Subjected to Single-Phase External Flow and Two-Phase Internal Flow

    International Nuclear Information System (INIS)

    Jong Chull Jo; Myung Jo Jhung; Woong Sik Kim; Hho Jung Kim

    2004-01-01

    This study investigates the fluid-elastic instability characteristics of steam generator helical type tubes in operating nuclear power plants. The thermal-hydraulic conditions of both tube side and shell side flow fields are predicted by a general purpose computational fluid dynamics code employing the finite volume element modeling. To get the natural frequency, corresponding mode shape and participation factor, modal analyses are performed for helical type tubes with various conditions. Investigated are the effects of the helix angle, the number of supports and the status of the inner fluid on the modal, and fluid-elastic instability characteristics of the tubes, which are expressed in terms of the natural frequency, corresponding mode shape, and stability ratio. (authors)

  18. An adaptive meshfree method for phase-field models of biomembranes. Part II: A Lagrangian approach for membranes in viscous fluids

    OpenAIRE

    Peco, C.; Rosolen, A.; Arroyo, M.

    2013-01-01

    We present a Lagrangian phase-field method to study the low Reynolds number dynamics of vesicles embedded in a viscous fluid. In contrast to previous approaches, where the field variables are the phase-field and the fluid velocity, here we exploit the fact that the phasefield tracks a material interface to reformulate the problem in terms of the Lagrangian motion of a background medium, containing both the biomembrane and the fluid. We discretize the equations in space with maximum-entr...

  19. Cryogenic Fluid Transfer Components Using Single Crystal Piezoelectric Actuators, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Cryogenic fluid transfer components using single crystal piezoelectric actuators are proposed to enable low thermal mass, minimal heat leak, low power consumption...

  20. An Automated High Aspect Ratio Mesher for Computational Fluid Dynamics, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Computational fluid dynamics (CFD) simulations are routinely used while designing, analyzing, and optimizing air- and spacecraft. An important component of CFD...

  1. Cryogenic Fluid Transfer Components Using Single Crystal Piezoelectric Actuators, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Cryogenic fluid transfer components using single crystal piezoelectric actuators are proposed to enable low thermal mass, minimal heat leak, low power consumption...

  2. Two-Phase Flow in Wire Coating with Heat Transfer Analysis of an Elastic-Viscous Fluid

    Directory of Open Access Journals (Sweden)

    Zeeshan Khan

    2016-01-01

    Full Text Available This work considers two-phase flow of an elastic-viscous fluid for double-layer coating of wire. The wet-on-wet (WOW coating process is used in this study. The analytical solution of the theoretical model is obtained by Optimal Homotopy Asymptotic Method (OHAM. The expression for the velocity field and temperature distribution for both layers is obtained. The convergence of the obtained series solution is established. The analytical results are verified by Adomian Decomposition Method (ADM. The obtained velocity field is compared with the existing exact solution of the same flow problem of second-grade fluid and with analytical solution of a third-grade fluid. Also, emerging parameters on the solutions are discussed and appropriate conclusions are drawn.

  3. Are separate-phase thermal-hydraulic models better than mixture-fluid approaches? It depends. Rather not

    International Nuclear Information System (INIS)

    Hoeld, A.

    2004-01-01

    The thermal-hydraulic theory of single- and especially two-phase flow systems used for plant transient analysis is dominated by separate-phase models. The corresponding mostly very comprehensive codes (TRAC, RELAP, CATHARE, ATHLET etc.) are looked as to be by far more efficient than a 3 eq. mixture-fluid approach and code also if they show deficiencies in describing flow situations within inner loops as for example the distribution into parallel channels (and thus the simulation of 3D thermal-hydraulic phenomena). This may be justified if comparing them to the very simple 'homogeneous equilibrium models (HEM)', but not if looking to the more refined non-homogeneous 'separate-region' mixture-fluid approaches based on appropriate drift-flux correlation packages which can have, on the contrary, enormous advantages with respect to such separate-phase models. Especially if comparing the basic (and starting) eqs. of such theoretical models of both types the differences are remarkable. Single-phase and mixture-fluid models start from genuine conservation eqs. for mass, energy and momentum, demanding (in case of two-phase flow) additionally an adequate drift flux package (in order to get a relation for a fourth independent variable), a heat transfer coefficients package (over the whole range of the possible fields of application) and correlations for single- and two-phase friction. The other types of models are looking at each phase separately with corresponding 'field' eqs. for each phase, connected by exchange (=closure) terms which substitute the classical constitutive packages for drift, heat transfer and friction. That the drift-flux, heat transfer into a coolant channel and friction along a wall and between the phases is described better by a separate-phase approach is at least doubtful. The corresponding mixture-fluid correlations are based over a wide range on a treasure of experience and measurements, their pseudo-stationary treatment can (due to their small time

  4. Multiparticle imaging technique for two-phase fluid flows using pulsed laser speckle velocimetry

    Energy Technology Data Exchange (ETDEWEB)

    Hassan, T.A.

    1992-12-01

    The practical use of Pulsed Laser Velocimetry (PLV) requires the use of fast, reliable computer-based methods for tracking numerous particles suspended in a fluid flow. Two methods for performing tracking are presented. One method tracks a particle through multiple sequential images (minimum of four required) by prediction and verification of particle displacement and direction. The other method, requiring only two sequential images uses a dynamic, binary, spatial, cross-correlation technique. The algorithms are tested on computer-generated synthetic data and experimental data which was obtained with traditional PLV methods. This allowed error analysis and testing of the algorithms on real engineering flows. A novel method is proposed which eliminates tedious, undersirable, manual, operator assistance in removing erroneous vectors. This method uses an iterative process involving an interpolated field produced from the most reliable vectors. Methods are developed to allow fast analysis and presentation of sets of PLV image data. Experimental investigation of a two-phase, horizontal, stratified, flow regime was performed to determine the interface drag force, and correspondingly, the drag coefficient. A horizontal, stratified flow test facility using water and air was constructed to allow interface shear measurements with PLV techniques. The experimentally obtained local drag measurements were compared with theoretical results given by conventional interfacial drag theory. Close agreement was shown when local conditions near the interface were similar to space-averaged conditions. However, theory based on macroscopic, space-averaged flow behavior was shown to give incorrect results if the local gas velocity near the interface as unstable, transient, and dissimilar from the average gas velocity through the test facility.

  5. Analytical predictions for vibration phase shifts along fluid-conveying pipes due to Coriolis forces and imperfections

    DEFF Research Database (Denmark)

    Thomsen, Jon Juel; Dahl, Jonas

    2010-01-01

    -shift measuring devices such as Coriolis mass flowmeters in particular. Small imperfections related to elastic and dissipative support conditions are specifically addressed, but the suggested approach is readily applicable to other kinds of imperfection, e.g. non-uniform stiffness or mass, non......-proportional damping, weak nonlinearity, and flow pulsation. A multiple time scaling perturbation analysis is employed for a simple model of an imperfect fluid-conveying pipe. This leads to simple analytical expressions for the approximate prediction of phase shift, providing direct insight into which imperfections...... the symmetric part of damping as well as non-uniformity in mass or stiffness do not affect phase shift. The validity of such hypotheses can be tested using detailed fluid-structure interaction computer models or laboratory experiments....

  6. Numerical modeling of two-phase binary fluid mixing using mixed finite elements

    KAUST Repository

    Sun, Shuyu; Firoozabadi, Abbas; Kou, Jisheng

    2012-01-01

    -phase flow in porous media is established based on Darcy's law, material balance, local thermodynamic equilibrium for the phases, and diffusion across the phases. The time-lag and operator-splitting techniques are used to decompose each convection

  7. Effect of wortmannin and phorbol ester on Paramecium fluid-phase uptake in the presence of transferrin

    Directory of Open Access Journals (Sweden)

    J Wiejak

    2009-12-01

    Full Text Available The kinetics of the uptake of the fluid phase marker Lucifer Yellow (LY, and its alteration by wortmannin, an inhibitor of phosphatidylinositol-3 kinase (PI-3K, and the PKC modulators: GF 109203 X, an inhibitor, and phorbol ester, an activator was studied in eukaryotic model Paramecium aurelia. Spectrophotometric quantification of LY accumulation was performed in the presence or absence of transferrin, a marker of receptor-mediated endocytosis. Internalization of LY showed a curvilinear kinetics: the high initial rate of LYuptake (575 ng LY/ mg protein /hr decreased almost 5-fold within 15 min, reaching plateau at 126 ng/ mg protein /hr. Transferrin induced a small increase (7.5% in the fluid phase uptake rate (after 5 min followed by a small decrease at longer incubation times. Lucifer Yellow and transferrin (visualized by streptavidin– FITC were localized in Paramecium by 3-D reconstruction by confocal microscopy. LY showed a scattered, diffuse fluorescence typical of fluid phase uptake whereas transferrin accumulated in membrane-surrounded endosomes. Wortmannin did not affect LY accumulation but decreased it when transferrin was present in the incubation medium. This suggests an effect on the transferrin uptake pathway, presumably on the stage of internalization in “mixing” endosomes to which transferrin and LY were targeted. Phorbol ester diminished LY accumulation by 22% and this effect persisted up to 25 min of incubation. PKC inhibitor did not affect LY uptake. However, in the presence of transferrin, the LY uptake increased within the first 15 minutes followed by a rapid 20% decrease in comparison to the control. Such an effect of PKC modulators suggests that PMA action on fluid phase uptake is not directly mediated by PKC.

  8. Investigating the Relationship between Cerebrospinal Fluid and Magnetic Induction Phase Shift in Rabbit Intracerebral hematoma expansion Monitoring by MRI

    OpenAIRE

    Chen, Mingsheng; Yan, Qingguang; Sun, Jian; Jin, Gui; Qin, Mingxin

    2017-01-01

    In a prior study of intracerebral hemorrhage monitoring using magnetic induction phase shift (MIPS), we found that MIPS signal changes occurred prior to those seen with intracranial pressure. However, the characteristic MIPS alert is not yet fully explained. Combining the brain physiology and MIPS theory, we propose that cerebrospinal fluid (CSF) may be the primary factor that leads to hematoma expansion being alerted by MIPS earlier than with intracranial pressure monitoring. This paper inve...

  9. The complete information for phenomenal distributed parameter control of multicomponent chemical processes in gas, fluid and solid phase

    International Nuclear Information System (INIS)

    Niemiec, W.

    1985-01-01

    A constitutive mathematical model of distributed parameters of multicomponent chemical processes in gas, fluid and solid phase is utilized to the realization of phenomenal distributed parameter control of these processes. Original systems of partial differential constitutive state equations, in the following derivative forms /I/, /II/ and /III/ are solved in this paper from the point of view of information for phenomenal distributed parameter control of considered processes. Obtained in this way for multicomponent chemical processes in gas, fluid and solid phase: -dynamical working space-time characteristics/analytical solutions in working space-time of chemical reactors/, -dynamical phenomenal Green functions as working space-time transfer functions, -statical working space characteristics /analytical solutions in working space of chemical reactors/, -statical phenomenal Green functions as working space transfer functions, are applied, as information for realization of constitutive distributed parameter control of mass, energy and momentum aspects of above processes. Two cases are considered by existence of: A/sup o/ - initial conditions, B/sup o/ - initial and boundary conditions, for multicomponent chemical processes in gas, fluid and solid phase

  10. Dynamics of snap-off and pore-filling events during two-phase fluid flow in permeable media.

    Science.gov (United States)

    Singh, Kamaljit; Menke, Hannah; Andrew, Matthew; Lin, Qingyang; Rau, Christoph; Blunt, Martin J; Bijeljic, Branko

    2017-07-12

    Understanding the pore-scale dynamics of two-phase fluid flow in permeable media is important in many processes such as water infiltration in soils, oil recovery, and geo-sequestration of CO 2 . The two most important processes that compete during the displacement of a non-wetting fluid by a wetting fluid are pore-filling or piston-like displacement and snap-off; this latter process can lead to trapping of the non-wetting phase. We present a three-dimensional dynamic visualization study using fast synchrotron X-ray micro-tomography to provide new insights into these processes by conducting a time-resolved pore-by-pore analysis of the local curvature and capillary pressure. We show that the time-scales of interface movement and brine layer swelling leading to snap-off are several minutes, orders of magnitude slower than observed for Haines jumps in drainage. The local capillary pressure increases rapidly after snap-off as the trapped phase finds a position that is a new local energy minimum. However, the pressure change is less dramatic than that observed during drainage. We also show that the brine-oil interface jumps from pore-to-pore during imbibition at an approximately constant local capillary pressure, with an event size of the order of an average pore size, again much smaller than the large bursts seen during drainage.

  11. Free energy and phase equilibria for the restricted primitive model of ionic fluids from Monte Carlo simulations

    International Nuclear Information System (INIS)

    Orkoulas, G.; Panagiotopoulos, A.Z.

    1994-01-01

    In this work, we investigate the liquid--vapor phase transition of the restricted primitive model of ionic fluids. We show that at the low temperatures where the phase transition occurs, the system cannot be studied by conventional molecular simulation methods because convergence to equilibrium is slow. To accelerate convergence, we propose cluster Monte Carlo moves capable of moving more than one particle at a time. We then address the issue of charged particle transfers in grand canonical and Gibbs ensemble Monte Carlo simulations, for which we propose a biased particle insertion/destruction scheme capable of sampling short interparticle distances. We compute the chemical potential for the restricted primitive model as a function of temperature and density from grand canonical Monte Carlo simulations and the phase envelope from Gibbs Monte Carlo simulations. Our calculated phase coexistence curve is in agreement with recent results of Caillol obtained on the four-dimensional hypersphere and our own earlier Gibbs ensemble simulations with single-ion transfers, with the exception of the critical temperature, which is lower in the current calculations. Our best estimates for the critical parameters are T * c =0.053, ρ * c =0.025. We conclude with possible future applications of the biased techniques developed here for phase equilibrium calculations for ionic fluids

  12. Flow rate impacts on capillary pressure and interface curvature of connected and disconnected fluid phases during multiphase flow in sandstone

    Science.gov (United States)

    Herring, Anna L.; Middleton, Jill; Walsh, Rick; Kingston, Andrew; Sheppard, Adrian

    2017-09-01

    We investigate capillary pressure-saturation (PC-S) relationships for drainage-imbibition experiments conducted with air (nonwetting phase) and brine (wetting phase) in Bentheimer sandstone cores. Three different flow rate conditions, ranging over three orders of magnitude, are investigated. X-ray micro-computed tomographic imaging is used to characterize the distribution and amount of fluids and their interfacial characteristics. Capillary pressure is measured via (1) bulk-phase pressure transducer measurements, and (2) image-based curvature measurements, calculated using a novel 3D curvature algorithm. We distinguish between connected (percolating) and disconnected air clusters: curvatures measured on the connected phase interfaces are used to validate the curvature algorithm and provide an indication of the equilibrium condition of the data; curvature and volume distributions of disconnected clusters provide insight to the snap-off processes occurring during drainage and imbibition under different flow rate conditions.

  13. Variation in supratentorial cerebrospinal fluid production rate in one day. Measurement by nontriggered phase-contrast magnetic resonance imaging

    International Nuclear Information System (INIS)

    Takahashi, Hiroto; Tanaka, Hisashi; Fujita, Norihiko; Murase, Kenya; Tomiyama, Noriyuki

    2011-01-01

    Measuring the cerebrospinal fluid (CSF) production rate is important for understanding the physiology related to normal conditions and neurological disorders. Triggered phase-contrast magnetic resonance imaging (MRI) has been used to measure CSF production rate, but the use of nontriggered phase-contrast MRI has not been reported. The purposes of this study were to assess the feasibility of using nontriggered phase-contrast MRI to measure CSF flow and to determine whether CSF production exhibits circadian rhythm. The feasibility of phase-contrast MRI was assessed with a phantom simulated human cerebral aqueduct. CSF flow through the cerebral aqueduct was measured with nontriggered phase-contrast MRI four times during 1 day in 10 normal volunteers. In the phantom study, linear regression analysis gave the following measured values (ml/h): 0.80 x (value of steady flow)-10.0 for triggered phase-contrast MRI and 1.27 x (value of steady flow)-12.2 for nontriggered phase-contrast MRI. One-factor analysis of variance showed no significant effect of the time of the measurements (P=0.47). The supratentorial CSF production rate was 510±549 ml/day (mean ± SD). Nontriggered phase-contrast MRI provided good estimates of the flow rate in the phantom study. We observed no circadian rhythm in CSF production. (author)

  14. Two-fluid model of two-phase flow in a pin bundle of a nuclear reactor

    International Nuclear Information System (INIS)

    Chawla, T.C.; Ishii, M.

    1980-01-01

    By considering two-phase flow as a field which is subdivided into two turbulent single-phase regions with moving boundaries separating the two constituent phases, such that the differential balances for three-dimensional turbulent flow hold for each subregion and for the interface, we perform the Eulerian area averaging over the cross-sectional area of each phase in a given channel and segment averaging of transverse momentum equation along the phase intercepts at the interchannel boundaries. To simplify the governing equations obtained as a result of these operations, we invoke the assumption that the motion of the fluid in each phase is dominantly in axial direction, that is the transverse components of velocity are small compared to axial components. We further assume that the variation of axial component of velocity within a channel is much stronger than the variation along the axial direction. We also assume that similar arguments can also be applied to the variation of enthalpy in a channel. As a result of these considerations, we obtain two sets of continuity, momentum, and energy equations describing motion of each phase in the axial direction. The phasic interaction terms which appear in these equations are governed by interfacial transfer conditions obtained from interface balances. The segment-averaged transverse-momentum equation for each phase provides the governing equation for cross flow. (author)

  15. Integrated Reacting Fluid Dynamics and Predictive Materials Degradation Models for Propulsion System Conditions, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Computational fluid dynamics (CFD) simulations are routinely used by NASA to optimize the design of propulsion systems. Current methods for CFD modeling rely on...

  16. Effectiveness of Nitrous Oxide as a Liquid Injection Thrust Vector Control Fluid, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Nitrous Oxide is proposed as an energetic liquid injection thrust vector control fluid for vehicle attitude control during dynamic vehicle maneuvers. Pulled from the...

  17. Plasma-treated carbonyl iron particles as a dispersed phase in magnetorheological fluids

    Czech Academy of Sciences Publication Activity Database

    Sedlačík, M.; Pavlínek, V.; Lehocký, M.; Mráček, A.; Grulich, O.; Švrčinová, Petra; Filip, Petr; Vesel, A.

    2011-01-01

    Roč. 387, 1-3 (2011), s. 99-103 ISSN 0927-7757 Grant - others:GA ČR(CZ) GD104/09/H080; OP VaVpI(XE) CZ.1.05/2.1.00/03.0111 Program:GD Institutional research plan: CEZ:AV0Z20600510 Keywords : carbonyl iron * magnetorheological fluid * plasma * viscoelasticity Subject RIV: BK - Fluid Dynamics Impact factor: 2.236, year: 2011

  18. Analysis of the two-fluid model in fully-developed two-phase flow

    International Nuclear Information System (INIS)

    Azpitarte, Osvaldo Enrique

    2003-01-01

    The two fluid model is analysed and applied to solve vertical fully-developed bubbly two-phase flows, both in laminar and turbulent conditions.The laminar model is reduced to two differential equations to solve the gas fraction (ε G ) and the velocity (υ L ).For the turbulent condition, a k - ε model for low Reynolds number is implemented, resulting in a set of differential equations to solve the four variables (ε G , υ L , k and ε) along the whole radial domain (including the laminar sub layer).For laminar condition, the system is initially reduced to a single non-dimensional ordinary equation (O D E) to solve ε G in the central region of the duct, without considering the effect of the wall.The equation is solved using Mathematic a.Analysing the solutions it can be concluded that an exact compensation of the applied pressure gradient with the hydrostatic force ρ e ff g occurs (ρ e ff : effective density of the mixture).This compensation implies that the value of ε G at the center of the duct only depends on the applied pressure gradient (dependency is linear), and that the ε G and υ L profiles are necessarily fl ato The complete problem is dealt numerically through the implementation of a finite element co deo The effect of the walls is included via a model of wall force.When the code is applied to a laminar condition, the conclusions previously obtained solving the O D E are confirmed.It is also possible to analyse the regime in which the pressure gradient is greater than the weight of the pure liquid, in which case a region of strictly zero void fraction develops surrounding the axis of the duct (in upward flow).When the code is applied to a turbulent condition, it is shown that the conclusions obtained for laminar condition can also be applied, but within a range of pressure gradient limited by two transition values (θ 1 and θ 2 ).An analysis of transitions θ 1 and θ 2 allows u s to conclude that their origin is a sudden increase of lateral

  19. Design of Accumulators and Liquid/Gas Charging of Single Phase Mechanically Pumped Fluid Loop Heat Rejection Systems

    Science.gov (United States)

    Bhandari, Pradeep; Dudik, Brenda; Birur, Gajanana; Karlmann, Paul; Bame, David; Mastropietro, A. J.

    2012-01-01

    For single phase mechanically pumped fluid loops used for thermal control of spacecraft, a gas charged accumulator is typically used to modulate pressures within the loop. This is needed to accommodate changes in the working fluid volume due to changes in the operating temperatures as the spacecraft encounters varying thermal environments during its mission. Overall, the three key requirements on the accumulator to maintain an appropriate pressure range throughout the mission are: accommodation of the volume change of the fluid due to temperature changes, avoidance of pump cavitation and prevention of boiling in the liquid. The sizing and design of such an accumulator requires very careful and accurate accounting of temperature distribution within each element of the working fluid for the entire range of conditions expected, accurate knowledge of volume of each fluid element, assessment of corresponding pressures needed to avoid boiling in the liquid, as well as the pressures needed to avoid cavitation in the pump. The appropriate liquid and accumulator strokes required to accommodate the liquid volume change, as well as the appropriate gas volumes, require proper sizing to ensure that the correct pressure range is maintained during the mission. Additionally, a very careful assessment of the process for charging both the gas side and the liquid side of the accumulator is required to properly position the bellows and pressurize the system to a level commensurate with requirements. To achieve the accurate sizing of the accumulator and the charging of the system, sophisticated EXCEL based spreadsheets were developed to rapidly come up with an accumulator design and the corresponding charging parameters. These spreadsheets have proven to be computationally fast and accurate tools for this purpose. This paper will describe the entire process of designing and charging the system, using a case study of the Mars Science Laboratory (MSL) fluid loops, which is en route to

  20. In Situ Decommissioning Sensor Network, Meso-Scale Test Bed - Phase 3 Fluid Injection Test Summary Report

    International Nuclear Information System (INIS)

    Serrato, M. G.

    2013-01-01

    located at the Florida International University Applied Research Center, Miami, FL (FIU-ARC). A follow-on fluid injection test was developed to detect fluid and ion migration in a cementitious material/grouted test cube using a limited number of existing embedded sensor systems. This In Situ Decommissioning Sensor Network, Meso-Scale Test Bed (ISDSN-MSTB) - Phase 3 Fluid Injection Test Summary Report summarizes the test implementation, acquired and processed data, and results from the activated embedded sensor systems used during the fluid injection test. The ISDSN-MSTB Phase 3 Fluid Injection Test was conducted from August 27 through September 6, 2013 at the FIU-ARC ISDSN-MSTB test cube. The fluid injection test activated a portion of the existing embedded sensor systems in the ISDSN-MSTB test cube: Electrical Resistivity Tomography-Thermocouple Sensor Arrays, Advance Tensiometer Sensors, and Fiber Loop Ringdown Optical Sensors. These embedded sensor systems were activated 15 months after initial placement. All sensor systems were remotely operated and data acquisition was completed through the established Sensor Remote Access System (SRAS) hosted on the DOE D&D Knowledge Management Information Tool (D&D DKM-IT) server. The ISDN Phase 3 Fluid Injection Test successfully demonstrated the feasibility of embedding sensor systems to assess moisture-fluid flow and resulting transport potential for contaminate mobility through a cementitious material/grout monolith. The ISDSN embedded sensor systems activated for the fluid injection test highlighted the robustness of the sensor systems and the importance of configuring systems in-depth (i.e., complementary sensors and measurements) to alleviate data acquisition gaps

  1. In Situ Decommissioning Sensor Network, Meso-Scale Test Bed - Phase 3 Fluid Injection Test Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Serrato, M. G.

    2013-09-27

    located at the Florida International University Applied Research Center, Miami, FL (FIU-ARC). A follow-on fluid injection test was developed to detect fluid and ion migration in a cementitious material/grouted test cube using a limited number of existing embedded sensor systems. This In Situ Decommissioning Sensor Network, Meso-Scale Test Bed (ISDSN-MSTB) - Phase 3 Fluid Injection Test Summary Report summarizes the test implementation, acquired and processed data, and results from the activated embedded sensor systems used during the fluid injection test. The ISDSN-MSTB Phase 3 Fluid Injection Test was conducted from August 27 through September 6, 2013 at the FIU-ARC ISDSN-MSTB test cube. The fluid injection test activated a portion of the existing embedded sensor systems in the ISDSN-MSTB test cube: Electrical Resistivity Tomography-Thermocouple Sensor Arrays, Advance Tensiometer Sensors, and Fiber Loop Ringdown Optical Sensors. These embedded sensor systems were activated 15 months after initial placement. All sensor systems were remotely operated and data acquisition was completed through the established Sensor Remote Access System (SRAS) hosted on the DOE D&D Knowledge Management Information Tool (D&D DKM-IT) server. The ISDN Phase 3 Fluid Injection Test successfully demonstrated the feasibility of embedding sensor systems to assess moisture-fluid flow and resulting transport potential for contaminate mobility through a cementitious material/grout monolith. The ISDSN embedded sensor systems activated for the fluid injection test highlighted the robustness of the sensor systems and the importance of configuring systems in-depth (i.e., complementary sensors and measurements) to alleviate data acquisition gaps.

  2. Isostructural solid-solid phase transition in monolayers of soft core-shell particles at fluid interfaces: structure and mechanics.

    Science.gov (United States)

    Rey, Marcel; Fernández-Rodríguez, Miguel Ángel; Steinacher, Mathias; Scheidegger, Laura; Geisel, Karen; Richtering, Walter; Squires, Todd M; Isa, Lucio

    2016-04-21

    We have studied the complete two-dimensional phase diagram of a core-shell microgel-laden fluid interface by synchronizing its compression with the deposition of the interfacial monolayer. Applying a new protocol, different positions on the substrate correspond to different values of the monolayer surface pressure and specific area. Analyzing the microstructure of the deposited monolayers, we discovered an isostructural solid-solid phase transition between two crystalline phases with the same hexagonal symmetry, but with two different lattice constants. The two phases corresponded to shell-shell and core-core inter-particle contacts, respectively; with increasing surface pressure the former mechanically failed enabling the particle cores to come into contact. In the phase-transition region, clusters of particles in core-core contacts nucleate, melting the surrounding shell-shell crystal, until the whole monolayer moves into the second phase. We furthermore measured the interfacial rheology of the monolayers as a function of the surface pressure using an interfacial microdisk rheometer. The interfaces always showed a strong elastic response, with a dip in the shear elastic modulus in correspondence with the melting of the shell-shell phase, followed by a steep increase upon the formation of a percolating network of the core-core contacts. These results demonstrate that the core-shell nature of the particles leads to a rich mechanical and structural behavior that can be externally tuned by compressing the interface, indicating new routes for applications, e.g. in surface patterning or emulsion stabilization.

  3. Fluid-Elastic Instability of U-Tube Bundle in Air-Water Two-Phase Flow

    International Nuclear Information System (INIS)

    Chu, In Cheol; Lee, Chang Hee; Yun, Young Jung; Chung, Heung June

    2007-03-01

    Using steam generator U-tube flow-induced vibration test facility, the flow-induced vibration characteristics of U-tube in row 34-44 and line 71-77 were investigated. Air and water at room temperature and near atmospheric pressure were used as working fluids. In the present experiments, followings were evaluated under two-phase cross-flow condition: the fundamental vibration responses and the critical gap velocity for a fluid-elastic instability of U-tubes, the damping ratio and hydrodynamic mass of U-tubes. In addition, the fluid-elastic instability factor, K, was preliminary assessed using Connors' relation. In the case of the U-tubes which are not supported by partial egg-crate in OPR100 steam generator, it has been found that the vibration displacement of those U-tubes are highly possible to exceed the design limit even by a turbulent excitation mechanism. The damping ratio of U-tubes measured in the present experiments was significantly higher than the OPR1000 steam generator design value. The fluid-elastic instability factor of U-tube bundle obtained in the present experiments were preliminary evaluated to be mostly in the range of 6.5-10.5

  4. The analysis of two-phase flow and heat transfer using a multidimensional, four field, two-fluid model

    International Nuclear Information System (INIS)

    Lahey, Richard T.; Drew, Donald A.

    2001-01-01

    This paper reviews the state-of-the-art in the prediction of multidimensional multiphase flow and heat transfer phenomena using a four field, two-fluid model. It is shown that accurate mechanistic computational fluid dynamic (CFD) predictions are possible for a wide variety of adiabatic and diabatic flows using this computational model. In particular, the model is able to predict the bubbly air/water upflow data of Serizawa (Serizawa, A., 1974. Fluid dynamic characteristics of two-phase flow. Ph.D. thesis, (Nuclear Engineering), Kyoto University, Japan), the downflow data of Wang et al. (Wang, S.K., Lee, S.J., Lahey Jr., R.T., Jones, O.C., 1987. 3-D turbulence structure and phase distribution measurements in bubbly two-phase flows. Int. J. Multiphase Flow 13 (3), 327-343), the isosceles triangle upflow data of Lopez de Bertodano et al. (Lopez de Bertodano, M., Lahey Jr., R.T., Jones, O.C., 1994b. Phase distribution in bubbly two-phase flow in vertical ducts. Int. J. Multiphase Flow 20 (5), 805-818), the heated annular R-113 subcooled boiling data of Velidandala, et al. (Velidandla, V., Pulta, S., Roy, P., Kaira, S.P., 1995. Velocity field in turbulent subcooled boiling flow. ASME Preprint HTD-314, 107-123) and the R-113 CHF data of Hino and Ueda (Hino, R., Ueda, T., 1985. Studies on heat transfer and flow characteristics in subcooled boiling-part 2, flow characteristics. Int. J. Multiphase Flow 11, 283-297). It can also predict external two-phase flows, such as those for spreading two-phase jets (Bonetto, F., Lahey Jr., R.T., 1993. An experimental study on air carryunder due to a plunging liquid jet. Int. J. Multiphase Flow 19 (2), 281-294) and multiphase flows around the hull of naval surface ships (Carrica, P.M., Bonetto, F., Drew, D.A., Lahey, R.T., 1999. A polydispersed model for bubbly two-phase flow around a surface ship. Int. J. Multiphase Flow 25 (2), 257-305)

  5. Effect of phase behavior, density, and isothermal compressibility on the constant-volume heat capacity of ethane + n-pentane mixed fluids in different phase regions

    International Nuclear Information System (INIS)

    Mu, Tiancheng; Liu, Zhimin; Han, Buxing.; Li, Zhonghao; Zhang, Jianling; Zhang, Xiaogang

    2003-01-01

    The phase behavior, density, and constant-volume molar heat capacity (C v,m ) of ethane + n-pentane binary mixtures have been measured in the supercritical region and subcritical region at T=309.45 K. In addition, the isothermal compressibility (κ T ) has been calculated using the density data determined. For a mixed fluid with a composition close to the critical composition, C v,m and κ T increase sharply as the pressure approaches the critical point (CP), the dew point (DP), or the bubble point (BP). However, C v,m is not sensitive to pressure in the entire pressure range if the composition of the mixed fluid is far from the critical composition. To tune the properties of the binary mixtures effectively by pressure, both the composition and the pressure should be close to the critical point of the mixture. The intermolecular interactions in the mixture are also discussed on the basis of the experimental results

  6. Fluid phase equilibria during propylene carbonate synthesis from propylene oxide in carbon dioxide medium

    DEFF Research Database (Denmark)

    Gharnati, Loubna; Musko, Nikolai; Jensen, Anker Degn

    2013-01-01

    -cyclic guanidinium bromide on SBA-15 (HEPCGBr/SBA-15) as catalyst in the absence of any co-catalyst. It was found that the yield was strongly dependent on the amount of CO2 added to the system and that the phase behavior strongly changes along the reaction pathway. The Cubic-Plus-Association (CPA) equation of state...... was used to predict the phase behavior during the reaction and the number and composition of coexisting phases in the multicomponent reaction system were determined. In accordance with the experimental data, the maximum conversion was achieved in the transition region between the two- and the one-phase...... region where a CO2-expanded reactant/product phase (larger volume due to the dissolution of carbon dioxide in the liquid phase) is present. Optimal conditions for performing the reaction have been derived which requires consideration not only of the phase behavior of the starting phase but also...

  7. Circumferential-wave phase velocities for empty, fluid-immersed spherical metal shells

    DEFF Research Database (Denmark)

    Überall, Herbert; Claude Ahyi, A.; Raju, P. K.

    2001-01-01

    Our earlier studies regarding acoustic scattering resonances and the dispersive phase velocities of the surface waves that generate them, have demonstrated the effectiveness of obtaining phase velocity dispersion curves from the known acoustic resonance frequencies, and their accuracy. This possi...

  8. Validation of two-phase CFD models for propellant tank self-pressurization: Crossing fluid types, scales, and gravity levels

    Science.gov (United States)

    Kassemi, Mohammad; Kartuzova, Olga; Hylton, Sonya

    2018-01-01

    This paper examines our computational ability to capture the transport and phase change phenomena that govern cryogenic storage tank pressurization and underscores our strengths and weaknesses in this area in terms of three computational-experimental validation case studies. In the first study, 1g pressurization of a simulant low-boiling point fluid in a small scale transparent tank is considered in the context of the Zero-Boil-Off Tank (ZBOT) Experiment to showcase the relatively strong capability that we have developed in modelling the coupling between the convective transport and stratification in the bulk phases with the interfacial evaporative and condensing heat and mass transfer that ultimately control self-pressurization in the storage tank. Here, we show that computational predictions exhibit excellent temporal and spatial fidelity under the moderate Ra number - high Bo number convective-phase distribution regimes. In the second example, we focus on 1g pressurization and pressure control of the large-scale K-site liquid hydrogen tank experiment where we show that by crossing fluid types and physical scales, we enter into high Bo number - high Ra number flow regimes that challenge our ability to predict turbulent heat and mass transfer and their impact on the tank pressurization correctly, especially, in the vapor domain. In the final example, we examine pressurization results from the small scale simulant fluid Tank Pressure Control Experiment (TCPE) performed in microgravity to underscore the fact that in crossing into a low Ra number - low Bo number regime in microgravity, the temporal evolution of the phase front as affected by the time-dependent residual gravity and impulse accelerations becomes an important consideration. In this case detailed acceleration data are needed to predict the correct rate of tank self-pressurization.

  9. Mathematical modelling and numerical resolution of multi-phase compressible fluid flows problems

    International Nuclear Information System (INIS)

    Lagoutiere, Frederic

    2000-01-01

    This work deals with Eulerian compressible multi-species fluid dynamics, the species being either mixed or separated (with interfaces). The document is composed of three parts. The first parts devoted to the numerical resolution of model problems: advection equation, Burgers equation, and Euler equations, in dimensions one and two. The goal is to find a precise method, especially for discontinuous initial conditions, and we develop non dissipative algorithms. They are based on a downwind finite-volume discretization under some stability constraints. The second part treats of the mathematical modelling of fluids mixtures. We construct and analyse a set of multi-temperature and multi-pressure models that are entropy, symmetrizable, hyperbolic, not ever conservative. In the third part, we apply the ideas developed in the first part (downwind discretization) to the numerical resolution of the partial differential problems we have constructed for fluids mixtures in the second part. We present some numerical results in dimensions one and two. (author) [fr

  10. Modeling Two-Phase Flow and Vapor Cycles Using the Generalized Fluid System Simulation Program

    Science.gov (United States)

    Smith, Amanda D.; Majumdar, Alok K.

    2017-01-01

    This work presents three new applications for the general purpose fluid network solver code GFSSP developed at NASA's Marshall Space Flight Center: (1) cooling tower, (2) vapor-compression refrigeration system, and (3) vapor-expansion power generation system. These systems are widely used across engineering disciplines in a variety of energy systems, and these models expand the capabilities and the use of GFSSP to include fluids and features that are not part of its present set of provided examples. GFSSP provides pressure, temperature, and species concentrations at designated locations, or nodes, within a fluid network based on a finite volume formulation of thermodynamics and conservation laws. This paper describes the theoretical basis for the construction of the models, their implementation in the current GFSSP modeling system, and a brief evaluation of the usefulness of the model results, as well as their applicability toward a broader spectrum of analytical problems in both university teaching and engineering research.

  11. Equation-of-State Modeling of Phase Equilibria in Petroleum Fluids

    DEFF Research Database (Denmark)

    Jørgensen, Marianne

    1996-01-01

    The Soave-Redlich-Kwong (SRK) equation of state was used to investigate and develop several aspects of the modeling of natural petroleum fluids.A new method was presented for numerical evaluation of PVT experiments. This method was used in the estimation of binary interaction parameters. A comphr......The Soave-Redlich-Kwong (SRK) equation of state was used to investigate and develop several aspects of the modeling of natural petroleum fluids.A new method was presented for numerical evaluation of PVT experiments. This method was used in the estimation of binary interaction parameters....... A comphrensive study of pseudoization procedures is presented. It is concluded that the compared methods exhibit results of comparable accuracy, and that six to eight pseudocomponents are needed for optimal representation of petroleum fluids.Finally, it is investigated how well the EOS can represent the VLLE...

  12. Derivation of simplified basic equations of gas-liquid two-phase dispersed flow based on two-fluid model

    International Nuclear Information System (INIS)

    Kataoka, Isao; Tomiyama, Akio

    2004-01-01

    The simplified and physically reasonable basic equations for the gas-liquid dispersed flow were developed based on some appropriate assumptions and the treatment of dispersed phase as isothermal rigid particles. Based on the local instant formulation of mass, momentum and energy conservation of the dispersed flow, time-averaged equations were obtained assuming that physical quantities in the dispersed phase are uniform. These assumptions are approximately valid when phase change rate and/or chemical reaction rate are not so large at gas-liquid interface and there is no heat generation in within the dispersed phase. Detailed discussions were made on the characteristics of obtained basic equations and physical meanings of terms consisting the basic equations. It is shown that, in the derived averaged momentum equation, the terms of pressure gradient and viscous momentum diffusion do not appear and, in the energy equation, the term of molecular thermal diffusion heat flux does not appear. These characteristics of the derived equations were shown to be very consistent concerning the physical interpretation of the gas-liquid dispersed flow. Furthermore, the obtained basic equations are consistent with experiments for the dispersed flow where most of averaged physical quantities are obtained assuming that the distributions of those are uniform within the dispersed phase. Investigation was made on the problem whether the obtained basic equations are well-posed or ill-posed for the initial value problem. The eigenvalues of the simplified mass and momentum equations are calculated for basic equations obtained here and previous two-fluid basic equations with one pressure model. Well-posedness and ill-posedness are judged whether the eigenvalues are real or imaginary. The result indicated the newly developed basic equations always constitute the well-posed initial value problem while the previous two-fluid basic equations based on one pressure model constitutes ill

  13. Solid-Phase Extraction Strategies to Surmount Body Fluid Sample Complexity in High-Throughput Mass Spectrometry-Based Proteomics

    Science.gov (United States)

    Bladergroen, Marco R.; van der Burgt, Yuri E. M.

    2015-01-01

    For large-scale and standardized applications in mass spectrometry- (MS-) based proteomics automation of each step is essential. Here we present high-throughput sample preparation solutions for balancing the speed of current MS-acquisitions and the time needed for analytical workup of body fluids. The discussed workflows reduce body fluid sample complexity and apply for both bottom-up proteomics experiments and top-down protein characterization approaches. Various sample preparation methods that involve solid-phase extraction (SPE) including affinity enrichment strategies have been automated. Obtained peptide and protein fractions can be mass analyzed by direct infusion into an electrospray ionization (ESI) source or by means of matrix-assisted laser desorption ionization (MALDI) without further need of time-consuming liquid chromatography (LC) separations. PMID:25692071

  14. Determination of amphetamine-type stimulants in oral fluid by solid-phase microextraction and gas chromatography-mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Daniele Z., E-mail: daniele.dzs@dpf.gov.br [Setor Tecnico-Cientifico, Superintendencia Regional do Departamento de Policia Federal no Rio Grande do Sul, 1365 Ipiranga Avenue, Azenha, Zip Code 90160-093 Porto Alegre, Rio Grande do Sul (Brazil); Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, 2752 Ipiranga Avenue, Santana, Zip Code 90610-000 Porto Alegre, Rio Grande do Sul (Brazil); Boehl, Paula O.; Comiran, Eloisa; Mariotti, Kristiane C. [Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, 2752 Ipiranga Avenue, Santana, Zip Code 90610-000 Porto Alegre, Rio Grande do Sul (Brazil); Pechansky, Flavio [Centro de Pesquisa em Alcool e Drogas (CPAD), Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 2350, Ramiro Barcelos Street, Zip Code 90035-903 Porto Alegre, Rio Grande do Sul (Brazil); Duarte, Paulina C.A.V. [Secretaria Nacional de Politicas sobre Drogas (SENAD), Esplanada dos Ministerios, Block ' A' , 5th floor, Zip Code 70050-907 Brasilia, Distrito Federal (Brazil); De Boni, Raquel [Centro de Pesquisa em Alcool e Drogas (CPAD), Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, 2350, Ramiro Barcelos Street, Zip Code 90035-903 Porto Alegre, Rio Grande do Sul (Brazil); Froehlich, Pedro E.; Limberger, Renata P. [Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, 2752 Ipiranga Avenue, Santana, Zip Code 90610-000 Porto Alegre, Rio Grande do Sul (Brazil)

    2011-06-24

    Graphical abstract: Highlights: > Propylchloroformate derivatization of amphetamine-type stimulants in oral fluid. > Direct immersion solid-phase microextraction/gas chromatography-mass spectrometry. > Linear range 2(4)-256 ng mL{sup -1}, detection limits 0.5-2 ng mL{sup -1}. > Accuracy 98-112%, precision <15% of RSD, recovery 77-112%. > Importance of residual evaluation in checking model goodness-of-fit. - Abstract: A method for the simultaneous identification and quantification of amphetamine (AMP), methamphetamine (MET), fenproporex (FEN), diethylpropion (DIE) and methylphenidate (MPH) in oral fluid collected with Quantisal{sup TM} device has been developed and validated. Thereunto, in-matrix propylchloroformate derivatization followed by direct immersion solid-phase microextraction and gas chromatography-mass spectrometry were employed. Deuterium labeled AMP was used as internal standard for all the stimulants and analysis was performed using the selected ion monitoring mode. The detector response was linear for the studied drugs in the concentration range of 2-256 ng mL{sup -1} (neat oral fluid), except for FEN, whereas the linear range was 4-256 ng mL{sup -1}. The detection limits were 0.5 ng mL{sup -1} (MET), 1 ng mL{sup -1} (MPH) and 2 ng mL{sup -1} (DIE, AMP, FEN), respectively. Accuracy of quality control samples remained within 98.2-111.9% of the target concentrations, while precision has not exceeded 15% of the relative standard deviation. Recoveries with Quantisal{sup TM} device ranged from 77.2% to 112.1%. Also, the goodness-of-fit concerning the ordinary least squares model in the statistical inference of data has been tested through residual plotting and ANOVA. The validated method can be easily automated and then used for screening and confirmation of amphetamine-type stimulants in drivers' oral fluid.

  15. Phase Equilibrium Calculations for Multi-Component Polar Fluid Mixtures with tPC-PSAFT

    DEFF Research Database (Denmark)

    Karakatsani, Eirini; Economou, Ioannis

    2007-01-01

    The truncated Perturbed-Chain Polar Statistical Associating Fluid Theory (tPC-PSAFT) is applied to a number of different mixtures, including binary, ternary and quaternary mixtures of components that differ substantially in terms of intermolecular interactions and molecular size. In contrast to m...

  16. An experimental study of the latent functionally thermal fluid with micro-encapsulated phase change material particles flowing in microchannels

    International Nuclear Information System (INIS)

    Wang, Yan; Chen, Zhenqian; Ling, Xiang

    2016-01-01

    Graphical abstract: Fig. 1. Relationship between Nu and Re for MEPCM slurry with various particle volume fractions. The interrupt of the well dispersed particles would destroy the thermal boundary layer and reduces its thickness, resulting in large Nusselt number for the suspension with 2% volume fraction of MEPCM. Large amount of heat could be absorbed and transferred rapidly during MEPCM melting process, which would result in remarkable increase of Nusselt number. The heat transfer performance of latent thermal fluid would be enhanced as 1.34 times of that of pure water. With smaller particle volume fraction (1% in this context), phase change occurs at lower temperature and more intensive heat flux is required for higher concentration suspension to induce the phase change occurrence, which is useful for application of the thermal management design. - Highlights: • The experiments of latent fluid flowing in parallel microchannels were conducted. • The performance of water with well dispersed micro-encapsulated phase change material particles was examined. • The Nusselt number of MEPCM slurry could achieve 1.36 times as that of pure water. - Abstract: Phase change material holds a good promise as a media of thermal energy storage and intensive heat flux removal. In this context, experiments were conducted to investigate the hydrodynamic and thermodynamic properties of a latent thermal fluid, which consisted of water and well dispersed micro-encapsulated phase change material (MEPCM) particles, flowing in parallel microchannels. It is suggested that MEPCM particles loading induces much higher pressure drop, which is very sensitive to temperature. Compared against water, the heat transfer performance of MEPCM slurry performs much better owing to particles aggregation, collision and micro-convective around the particles. Besides these, latent heat absorbed during phase change process makes the key contribution. It is found that with melting occurrence, Nusselt

  17. Textural and fluid phase analysis of rock salt subjected to the combined effects of pressure, heat and gamma radiation

    International Nuclear Information System (INIS)

    Huertas, F.; Major, J.C.; Del Olmo, C.

    1992-01-01

    The formation of colloidal sodium by radiolytic processes is a main concern with respect to the safety of disposal of high-level radioactive waste in salt formations. The research work seeks to assess the irradiation damage in natural rock salt when exposed to a different dose, dose rate, temperature and time of gamma irradiation. The work encompasses four major tasks: (i) detailed characterization of both solid and fluid phases of natural rock salt; (ii) gamma irradiation of salt samples; (iii) determination of the amount of colloidal sodium present in irradiated samples; (iv) calculation of radiation damage. 40 refs., 36 figs., 34 tabs

  18. Results of the Workshop on Two-Phase Flow, Fluid Stability and Dynamics: Issues in Power, Propulsion, and Advanced Life Support Systems

    Science.gov (United States)

    McQuillen, John; Rame, Enrique; Kassemi, Mohammad; Singh, Bhim; Motil, Brian

    2003-01-01

    The Two-phase Flow, Fluid Stability and Dynamics Workshop was held on May 15, 2003 in Cleveland, Ohio to define a coherent scientific research plan and roadmap that addresses the multiphase fluid problems associated with NASA s technology development program. The workshop participants, from academia, industry and government, prioritized various multiphase issues and generated a research plan and roadmap to resolve them. This report presents a prioritization of the various multiphase flow and fluid stability phenomena related primarily to power, propulsion, fluid and thermal management and advanced life support; and a plan to address these issues in a logical and timely fashion using analysis, ground-based and space-flight experiments.

  19. In-Space technology experiments program. A high efficiency thermal interface (using condensation heat transfer) between a 2-phase fluid loop and heatpipe radiator: Experiment definition phase

    Science.gov (United States)

    Pohner, John A.; Dempsey, Brian P.; Herold, Leroy M.

    1990-01-01

    Space Station elements and advanced military spacecraft will require rejection of tens of kilowatts of waste heat. Large space radiators and two-phase heat transport loops will be required. To minimize radiator size and weight, it is critical to minimize the temperature drop between the heat source and sink. Under an Air Force contract, a unique, high-performance heat exchanger is developed for coupling the radiator to the transport loop. Since fluid flow through the heat exchanger is driven by capillary forces which are easily dominated by gravity forces in ground testing, it is necessary to perform microgravity thermal testing to verify the design. This contract consists of an experiment definition phase leading to a preliminary design and cost estimate for a shuttle-based flight experiment of this heat exchanger design. This program will utilize modified hardware from a ground test program for the heat exchanger.

  20. Computational fluid dynamics modeling of two-phase flow in a BWR fuel assembly. Final CRADA Report

    International Nuclear Information System (INIS)

    Tentner, A.

    2009-01-01

    A direct numerical simulation capability for two-phase flows with heat transfer in complex geometries can considerably reduce the hardware development cycle, facilitate the optimization and reduce the costs of testing of various industrial facilities, such as nuclear power plants, steam generators, steam condensers, liquid cooling systems, heat exchangers, distillers, and boilers. Specifically, the phenomena occurring in a two-phase coolant flow in a BWR (Boiling Water Reactor) fuel assembly include coolant phase changes and multiple flow regimes which directly influence the coolant interaction with fuel assembly and, ultimately, the reactor performance. Traditionally, the best analysis tools for this purpose of two-phase flow phenomena inside the BWR fuel assembly have been the sub-channel codes. However, the resolution of these codes is too coarse for analyzing the detailed intra-assembly flow patterns, such as flow around a spacer element. Advanced CFD (Computational Fluid Dynamics) codes provide a potential for detailed 3D simulations of coolant flow inside a fuel assembly, including flow around a spacer element using more fundamental physical models of flow regimes and phase interactions than sub-channel codes. Such models can extend the code applicability to a wider range of situations, which is highly important for increasing the efficiency and to prevent accidents.

  1. Circumferential-wave phase velocities for empty, fluid-immersed spherical metal shells

    DEFF Research Database (Denmark)

    Überall, Herbert; Ahyi, A. C.; Raju, P. K.

    2002-01-01

    In earlier studies of acoustic scattering resonances and of the dispersive phase velocities of surface waves that generate them [see, e.g., Talmant et al., J. Acoust. Soc. Am. 86, 278–289 (1989) for spherical aluminum shells] we have demonstrated the effectiveness and accuracy of obtaining phase ...

  2. In-line Microwave Warmer for Blood and Intravenous Fluids. Phase 2.

    Science.gov (United States)

    1988-02-15

    occuring in the battlefield often requires restoring normothermia and infusion of fluids, such as saline or blood, into the patient. These two...elevation is required to restore normal body temperature in response to hypothermic cardioplegic arrest induced prior to the operation. 6 1.2 System... Microfiltration Devices," Acta Annaesth Scand, 23:40- 45, 1979. [20] K Linko, K Hynynen, "Erythrocyte Damage Caused by the Haemotherm Microwave Blood Warmer

  3. On the late phase of relaxation of two-dimensional fluids: turbulence of unitons

    International Nuclear Information System (INIS)

    Spineanu, F; Vlad, M

    2017-01-01

    The two-dimensional ideal fluid and the plasma confined by a strong magnetic field exhibit an intrinsic tendency to organization due to the inverse spectral cascade. In the asymptotic states reached at relaxation the turbulence has vanished and there are only coherent vortical structures. We are interested in the regime that precedes these ordered flow patterns, in which there still is turbulence and imperfect but robust structures have emerged. To develop an analytical description we propose to start from the stationary coherent states and (in the direction opposite to relaxation) explore the space of configurations before the extremum of the functional that defines the structures has been reached. We find necessary to assemble different but related models: point-like vortices, its field theoretical formulation as interacting matter and gauge fields, chiral model and surfaces with constant mean curvature. These models are connected by the similar ability to described randomly interacting coherent structures. They derive exactly the same equation for the asymptotic state (sinh-Poisson equation, confirmed by numerical calculation of fluid flows). The chiral model, to which one can arrive from self-duality equation of the field theoretical model for fluid and from constant mean curvature surface equations, appears to be the suitable analytical framework. Its solutions, the unitons, aquire dynamics when the system is not at the extremum of the action. In the present work we provide arguments that the underlying common nature of these models can be used to develop an approach to fluid and plasma states of turbulence interacting with structures. (paper)

  4. Gas-liquid Two Phase Flow Modelling of Incompressible Fluid and Experimental Validation Studies in Vertical Centrifugal Casting

    International Nuclear Information System (INIS)

    Zhou, J X; Shen, X; Yin, Y J; Guo, Z; Wang, H

    2015-01-01

    In this paper, Gas-liquid two phase flow mathematic models of incompressible fluid were proposed to explore the feature of fluid under certain centrifugal force in vertical centrifugal casting (VCC). Modified projection-level-set method was introduced to solve the mathematic models. To validate the simulation results, two methods were used in this study. In the first method, the simulation result of basic VCC flow process was compared with its analytic solution. The relationship between the numerical solution and deterministic analytic solution was presented to verify the correctness of numerical algorithms. In the second method, systematic water simulation experiments were developed. In this initial experiment, special experimental vertical centrifugal device and casting shapes were designed to describe typical mold-filling processes in VCC. High speed camera system and data collection devices were used to capture flow shape during the mold-filling process. Moreover, fluid characteristic at different rotation speed (from 40rpm, 60rpmand 80rpm) was discussed to provide comparative resource for simulation results. As compared with the simulation results, the proposed mathematical models could be proven and the experimental design could help us advance the accuracy of simulation and further studies for VCC. (paper)

  5. Determination of amphetamine-type stimulants in oral fluid by solid-phase microextraction and gas chromatography-mass spectrometry.

    Science.gov (United States)

    Souza, Daniele Z; Boehl, Paula O; Comiran, Eloisa; Mariotti, Kristiane C; Pechansky, Flavio; Duarte, Paulina C A V; De Boni, Raquel; Froehlich, Pedro E; Limberger, Renata P

    2011-06-24

    A method for the simultaneous identification and quantification of amphetamine (AMP), methamphetamine (MET), fenproporex (FEN), diethylpropion (DIE) and methylphenidate (MPH) in oral fluid collected with Quantisal™ device has been developed and validated. Thereunto, in-matrix propylchloroformate derivatization followed by direct immersion solid-phase microextraction and gas chromatography-mass spectrometry were employed. Deuterium labeled AMP was used as internal standard for all the stimulants and analysis was performed using the selected ion monitoring mode. The detector response was linear for the studied drugs in the concentration range of 2-256 ng mL(-1) (neat oral fluid), except for FEN, whereas the linear range was 4-256 ng mL(-1). The detection limits were 0.5 ng mL(-1) (MET), 1 ng mL(-1) (MPH) and 2 ng mL(-1) (DIE, AMP, FEN), respectively. Accuracy of quality control samples remained within 98.2-111.9% of the target concentrations, while precision has not exceeded 15% of the relative standard deviation. Recoveries with Quantisal™ device ranged from 77.2% to 112.1%. Also, the goodness-of-fit concerning the ordinary least squares model in the statistical inference of data has been tested through residual plotting and ANOVA. The validated method can be easily automated and then used for screening and confirmation of amphetamine-type stimulants in drivers' oral fluid. Copyright © 2011 Elsevier B.V. All rights reserved.

  6. Two-Phase Acto-Cytosolic Fluid Flow in a Moving Keratocyte: A 2D Continuum Model.

    Science.gov (United States)

    Nikmaneshi, M R; Firoozabadi, B; Saidi, M S

    2015-09-01

    The F-actin network and cytosol in the lamellipodia of crawling cells flow in a centripetal pattern and spout-like form, respectively. We have numerically studied this two-phase flow in the realistic geometry of a moving keratocyte. Cytosol has been treated as a low viscosity Newtonian fluid flowing through the high viscosity porous medium of F-actin network. Other involved phenomena including myosin activity, adhesion friction, and interphase interaction are also discussed to provide an overall view of this problem. Adopting a two-phase coupled model by myosin concentration, we have found new accurate perspectives of acto-cytosolic flow and pressure fields, myosin distribution, as well as the distribution of effective forces across the lamellipodia of a keratocyte with stationary shape. The order of magnitude method is also used to determine the contribution of forces in the internal dynamics of lamellipodia.

  7. Continued development of a semianalytical solution for two-phase fluid and heat flow in a porous medium

    Energy Technology Data Exchange (ETDEWEB)

    Doughty, C.; Pruess, K. [Lawrence Berkeley Lab., CA (United States)

    1991-06-01

    Over the past few years the authors have developed a semianalytical solution for transient two-phase water, air, and heat flow in a porous medium surrounding a constant-strength linear heat source, using a similarity variable {eta} = r/{radical}t. Although the similarity transformation approach requires a simplified geometry, all the complex physical mechanisms involved in coupled two-phase fluid and heat flow can be taken into account in a rigorous way, so that the solution may be applied to a variety of problems of current interest. The work was motivated by adverse to predict the thermohydrological response to the proposed geologic repository for heat-generating high-level nuclear wastes at Yucca Mountain, Nevada, in a partially saturated, highly fractured volcanic formation. The paper describes thermal and hydrologic conditions near the heat source; new features of the model; vapor pressure lowering; and the effective-continuum representation of a fractured/porous medium.

  8. A study to investigate viscous coupling effects on the hydraulic conductance of fluid layers in two-phase flow at the pore level.

    Science.gov (United States)

    Shams, Mosayeb; Raeini, Ali Q; Blunt, Martin J; Bijeljic, Branko

    2018-07-15

    This paper examines the role of momentum transfer across fluid-fluid interfaces in two-phase flow. A volume-of-fluid finite-volume numerical method is used to solve the Navier-Stokes equations for two-phase flow at the micro-scale. The model is applied to investigate viscous coupling effects as a function of the viscosity ratio, the wetting phase saturation and the wettability, for different fluid configurations in simple pore geometries. It is shown that viscous coupling effects can be significant for certain pore geometries such as oil layers sandwiched between water in the corner of mixed wettability capillaries. A simple parametric model is then presented to estimate general mobility terms as a function of geometric properties and viscosity ratio. Finally, the model is validated by comparison with the mobilities computed using direct numerical simulation. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  9. Strongly coupled fluid-particle flows in vertical channels. I. Reynolds-averaged two-phase turbulence statistics

    International Nuclear Information System (INIS)

    Capecelatro, Jesse; Desjardins, Olivier; Fox, Rodney O.

    2016-01-01

    Simulations of strongly coupled (i.e., high-mass-loading) fluid-particle flows in vertical channels are performed with the purpose of understanding the fundamental physics of wall-bounded multiphase turbulence. The exact Reynolds-averaged (RA) equations for high-mass-loading suspensions are presented, and the unclosed terms that are retained in the context of fully developed channel flow are evaluated in an Eulerian–Lagrangian (EL) framework for the first time. A key distinction between the RA formulation presented in the current work and previous derivations of multiphase turbulence models is the partitioning of the particle velocity fluctuations into spatially correlated and uncorrelated components, used to define the components of the particle-phase turbulent kinetic energy (TKE) and granular temperature, respectively. The adaptive spatial filtering technique developed in our previous work for homogeneous flows [J. Capecelatro, O. Desjardins, and R. O. Fox, “Numerical study of collisional particle dynamics in cluster-induced turbulence,” J. Fluid Mech. 747, R2 (2014)] is shown to accurately partition the particle velocity fluctuations at all distances from the wall. Strong segregation in the components of granular energy is observed, with the largest values of particle-phase TKE associated with clusters falling near the channel wall, while maximum granular temperature is observed at the center of the channel. The anisotropy of the Reynolds stresses both near the wall and far away is found to be a crucial component for understanding the distribution of the particle-phase volume fraction. In Part II of this paper, results from the EL simulations are used to validate a multiphase Reynolds-stress turbulence model that correctly predicts the wall-normal distribution of the two-phase turbulence statistics.

  10. Strongly coupled fluid-particle flows in vertical channels. I. Reynolds-averaged two-phase turbulence statistics

    Science.gov (United States)

    Capecelatro, Jesse; Desjardins, Olivier; Fox, Rodney O.

    2016-03-01

    Simulations of strongly coupled (i.e., high-mass-loading) fluid-particle flows in vertical channels are performed with the purpose of understanding the fundamental physics of wall-bounded multiphase turbulence. The exact Reynolds-averaged (RA) equations for high-mass-loading suspensions are presented, and the unclosed terms that are retained in the context of fully developed channel flow are evaluated in an Eulerian-Lagrangian (EL) framework for the first time. A key distinction between the RA formulation presented in the current work and previous derivations of multiphase turbulence models is the partitioning of the particle velocity fluctuations into spatially correlated and uncorrelated components, used to define the components of the particle-phase turbulent kinetic energy (TKE) and granular temperature, respectively. The adaptive spatial filtering technique developed in our previous work for homogeneous flows [J. Capecelatro, O. Desjardins, and R. O. Fox, "Numerical study of collisional particle dynamics in cluster-induced turbulence," J. Fluid Mech. 747, R2 (2014)] is shown to accurately partition the particle velocity fluctuations at all distances from the wall. Strong segregation in the components of granular energy is observed, with the largest values of particle-phase TKE associated with clusters falling near the channel wall, while maximum granular temperature is observed at the center of the channel. The anisotropy of the Reynolds stresses both near the wall and far away is found to be a crucial component for understanding the distribution of the particle-phase volume fraction. In Part II of this paper, results from the EL simulations are used to validate a multiphase Reynolds-stress turbulence model that correctly predicts the wall-normal distribution of the two-phase turbulence statistics.

  11. Large Lattice Discretization Effects on the Phase Coexistence of Ionic Fluids

    International Nuclear Information System (INIS)

    Panagiotopoulos, A.Z.; Kumar, S.K.

    1999-01-01

    We examine the phase behavior of lattice restricted primitive models for integer values of the ratio of ionic diameter to lattice spacing, ξ . For ξ≤2 , there is coexistence between a disordered phase and an antiferromagnetic phase, but no vapor-liquid equilibrium. For ξ≥3 , a region of normal vapor-liquid coexistence is found, with critical temperatures and densities which are very close to their continuous space counterparts. Our findings stress that lattice structure can result in qualitatively different physics from continuous space models, but that the two models converge even for relatively coarsely discretized lattices. copyright 1999 The American Physical Society

  12. Visualization of Two-Phase Fluid Distribution Using Laser Induced Exciplex Fluorescence

    Science.gov (United States)

    Kim, J. U.; Darrow, J.; Schock, H.; Golding, B.; Nocera, D.; Keller, P.

    1998-03-01

    Laser-induced exciplex (excited state complex) fluorescence has been used to generate two-dimensional images of dispersed liquid and vapor phases with spectrally resolved two-color emissions. In this method, the vapor phase is tagged by the monomer fluorescence while the liquid phase is tracked by the exciplex fluorescence. A new exciplex visualization system consisting of DMA and 1,4,6-TMN in an isooctane solvent was developed.(J.U. Kim et al., Chem. Phys. Lett. 267, 323-328 (1997)) The direct ca

  13. Evaluation of innovative stationary phase ligand chemistries and analytical conditions for the analysis of basic drugs by supercritical fluid chromatography.

    Science.gov (United States)

    Desfontaine, Vincent; Veuthey, Jean-Luc; Guillarme, Davy

    2016-03-18

    Similar to reversed phase liquid chromatography, basic compounds can be highly challenging to analyze by supercritical fluid chromatography (SFC), as they tend to exhibit poor peak shape, especially those with high pKa values. In this study, three new stationary phase ligand chemistries available in sub -2 μm particle sizes, namely 2-picolylamine (2-PIC), 1-aminoanthracene (1-AA) and diethylamine (DEA), were tested in SFC conditions for the analysis of basic drugs. Due to the basic properties of these ligands, it is expected that the repulsive forces may improve peak shape of basic substances, similarly to the widely used 2-ethypyridine (2-EP) phase. However, among the 38 tested basic drugs, less of 10% displayed Gaussian peaks (asymmetry between 0.8 and 1.4) using pure CO2/methanol on these phases. The addition of 10mM ammonium formate as mobile phase additive, drastically improved peak shapes and increased this proportion to 67% on 2-PIC. Introducing the additive in the injection solvent rather than in the organic modifier, gave acceptable results for 2-PIC only, with 31% of Gaussian peaks with an average asymmetry of 1.89 for the 38 selected basic drugs. These columns were also compared to hybrid silica (BEH), DIOL and 2-EP stationary phases, commonly employed in SFC. These phases commonly exhibit alternative retention and selectivity. In the end, the two most interesting ligands used as complementary columns were 2-PIC and BEH, as they provided suitable peak shapes for the basic drugs and almost orthogonal selectivities. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Estimation of the reactive mineral surface area during CO2-rich fluid-rock interaction: the influence of neogenic phases

    Science.gov (United States)

    Scislewski, A.; Zuddas, P.

    2010-12-01

    Mineral dissolution and precipitation reactions actively participate to control fluid chemistry during water-rock interaction. It is however, difficult to estimate and well normalize bulk reaction rates if the mineral surface area exposed to the aqueous solution and effectively participating on the reactions is unknown. We evaluated the changing of the reactive mineral surface area during the interaction between CO2-rich fluids and Albitite/Granitoid rocks (similar mineralogy but different abundances), reacting under flow-through conditions. Our methodology, adopting an inverse modeling approach, is based on the estimation of dissolution rate and reactive surface area of the different minerals participating in the reactions by the reconstruction the chemical evolution of the interacting fluids. The irreversible mass-transfer processes is defined by a fractional degree of advancement, while calculations were carried out for Albite, Microcline, Biotite and Calcite assuming that the ion activity of dissolved silica and aluminium ions was limited by the equilibrium with quartz and kaolinite. Irrespective of the mineral abundance in granite and albitite, we found that mineral dissolution rates did not change significantly in the investigated range of time where output solution’s pH remained in the range between 6 and 8, indicating that the observed variation in fluid composition depends not on pH but rather on the variation of the parent mineral’s reactive surface area. We found that the reactive surface area of Albite varied by more than 2 orders of magnitude, while Microcline, Calcite and Biotite surface areas changed by 1-2 orders of magnitude. We propose that parent mineral chemical heterogeneity and, particularly, the stability of secondary mineral phases may explain the observed variation of the reactive surface area of the minerals. Formation of coatings at the dissolving parent mineral surfaces significantly reduced the amount of surface available to react

  15. Fluid simulation of the phase-shift effect in hydrogen capacitively coupled plasmas: II. Radial uniformity of the plasma characteristics

    International Nuclear Information System (INIS)

    Zhang Yuru; Xu Xiang; Wang Younian; Bogaerts, Annemie

    2012-01-01

    A two-dimensional fluid model, including the full set of Maxwell equations, has been developed and applied to investigate the effect of a phase shift between two power sources on the radial uniformity of several plasma characteristics in a hydrogen capacitively coupled plasma. This study was carried out at various frequencies in the range 13.56-200 MHz. When the frequency is low, at 13.56 MHz, the plasma density is characterized by an off-axis peak when both power sources are in-phase (φ = 0), and the best radial uniformity is obtained at φ = π. This trend can be explained because the radial nonuniformity caused by the electrostatic edge effect can be effectively suppressed by the phase-shift effect at a phase difference equal to π. When the frequency rises to 60 MHz, the plasma density profiles shift smoothly from edge-peaked over uniform to centre-peaked as the phase difference increases, due to the pronounced standing-wave effect, and the best radial uniformity is reached at φ = 0.3π. At a frequency of 100 MHz, a similar behaviour is observed, except that the maximum of the plasma density moves again towards the radial edge at the reverse-phase case (φ = π), because of the dominant skin effect. When the frequency is 200 MHz, the bulk plasma density increases significantly with increasing phase-shift values, and a better uniformity is obtained at φ = 0.4π. This is because the density in the centre increases faster than at the radial edge as the phase difference rises, due to the increasing power deposition P z in the centre and the decreasing power density P r at the radial edge. As the phase difference increases to π, the maximum near the radial edge becomes obvious again. This is because the skin effect has a predominant influence on the plasma density under this condition, resulting in a high density at the radial edge. Moreover, the axial ion flux increases monotonically with phase difference, and exhibits similar profiles to the plasma density

  16. Rule-Based Multidisciplinary Tool for Unsteady Reacting Real-Fluid Flows, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Loci-STREAM is a CFD-based, multidisciplinary, high-fidelity design and analysis tool resulting from Phase I work whose objectives were: (a) to demonstrate the...

  17. Statistical and Fractal Processing of Phase Images of Human Biological Fluids

    Directory of Open Access Journals (Sweden)

    MARCHUK, Y. I.

    2010-11-01

    Full Text Available Performed in this work are complex statistical and fractal analyses of phase properties inherent to birefringence networks of liquid crystals consisting of optically-thin layers prepared from human bile. Within the framework of a statistical approach, the authors have investigated values and ranges for changes of statistical moments of the 1-st to 4-th orders that characterize coordinate distributions for phase shifts between orthogonal components of amplitudes inherent to laser radiation transformed by human bile with various pathologies. Using the Gramm-Charlie method, ascertained are correlation criteria for differentiation of phase maps describing pathologically changed liquid-crystal networks. In the framework of the fractal approach, determined are dimensionalities of self-similar coordinate phase distributions as well as features of transformation of logarithmic dependences for power spectra of these distributions for various types of human pathologies.

  18. Density-functional theory for fluid-solid and solid-solid phase transitions.

    Science.gov (United States)

    Bharadwaj, Atul S; Singh, Yashwant

    2017-03-01

    We develop a theory to describe solid-solid phase transitions. The density functional formalism of classical statistical mechanics is used to find an exact expression for the difference in the grand thermodynamic potentials of the two coexisting phases. The expression involves both the symmetry conserving and the symmetry broken parts of the direct pair correlation function. The theory is used to calculate phase diagram of systems of soft spheres interacting via inverse power potentials u(r)=ε(σ/r)^{n}, where parameter n measures softness of the potential. We find that for 1/nfcc) structure while for 1/n≥0.154 the body-centred-cubic (bcc) structure is preferred. The bcc structure transforms into the fcc structure upon increasing the density. The calculated phase diagram is in good agreement with the one found from molecular simulations.

  19. Determination of amphetamine-type stimulants in oral fluid by solid-phase microextraction and gas chromatography-mass spectrometry

    International Nuclear Information System (INIS)

    Souza, Daniele Z.; Boehl, Paula O.; Comiran, Eloisa; Mariotti, Kristiane C.; Pechansky, Flavio; Duarte, Paulina C.A.V.; De Boni, Raquel; Froehlich, Pedro E.; Limberger, Renata P.

    2011-01-01

    Graphical abstract: Highlights: → Propylchloroformate derivatization of amphetamine-type stimulants in oral fluid. → Direct immersion solid-phase microextraction/gas chromatography-mass spectrometry. → Linear range 2(4)-256 ng mL -1 , detection limits 0.5-2 ng mL -1 . → Accuracy 98-112%, precision TM device has been developed and validated. Thereunto, in-matrix propylchloroformate derivatization followed by direct immersion solid-phase microextraction and gas chromatography-mass spectrometry were employed. Deuterium labeled AMP was used as internal standard for all the stimulants and analysis was performed using the selected ion monitoring mode. The detector response was linear for the studied drugs in the concentration range of 2-256 ng mL -1 (neat oral fluid), except for FEN, whereas the linear range was 4-256 ng mL -1 . The detection limits were 0.5 ng mL -1 (MET), 1 ng mL -1 (MPH) and 2 ng mL -1 (DIE, AMP, FEN), respectively. Accuracy of quality control samples remained within 98.2-111.9% of the target concentrations, while precision has not exceeded 15% of the relative standard deviation. Recoveries with Quantisal TM device ranged from 77.2% to 112.1%. Also, the goodness-of-fit concerning the ordinary least squares model in the statistical inference of data has been tested through residual plotting and ANOVA. The validated method can be easily automated and then used for screening and confirmation of amphetamine-type stimulants in drivers' oral fluid.

  20. High-pressure fluid-phase equilibria: Experimental methods and systems investigated (2005-2008)

    DEFF Research Database (Denmark)

    Fonseca, José; Dohrn, Ralf; Peper, Stephanie

    2011-01-01

    %) have carbon dioxide as one of the components. Information on 206 pure components, 535 ternary systems of which 355 (66%) contain carbon dioxide, 163 multicomponent and complex systems, and 207 systems with hydrates is given. A continuation of the review series is planned, covering the years from 2009...... points, the solubility of high-boiling substances in supercritical fluids, the solubility of gases in liquids and the solubility (sorption) of volatile components in polymers are included. Most of experimental data in the literature has been given for binary systems. Of the 1469 binary systems, 796 (54...

  1. An energy stable evolution method for simulating two-phase equilibria of multi-component fluids at constant moles, volume and temperature

    KAUST Repository

    Kou, Jisheng; Sun, Shuyu; Wang, Xiuhua

    2016-01-01

    In this paper, we propose an energy-stable evolution method for the calculation of the phase equilibria under given volume, temperature, and moles (VT-flash). An evolution model for describing the dynamics of two-phase fluid system is based on Fick

  2. Separating the effects of repulsive and attractive forces on the phase diagram, interfacial, and critical properties of simple fluids.

    Science.gov (United States)

    Fuentes-Herrera, M; Moreno-Razo, J A; Guzmán, O; López-Lemus, J; Ibarra-Tandi, B

    2016-06-07

    Molecular simulations in the canonical and isothermal-isobaric ensembles were performed to study the effect of varying the shape of the intermolecular potential on the phase diagram, critical, and interfacial properties of model fluids. The molecular interactions were modeled by the Approximate Non-Conformal (ANC) theory potentials. Unlike the Lennard-Jones or Morse potentials, the ANC interactions incorporate parameters (called softnesses) that modulate the steepness of the potential in their repulsive and attractive parts independently. This feature allowed us to separate unambiguously the role of each region of the potential on setting the thermophysical properties. In particular, we found positive linear correlation between all critical coordinates and the attractive and repulsive softness, except for the critical density and the attractive softness which are negatively correlated. Moreover, we found that the physical properties related to phase coexistence (such as span of the liquid phase between the critical and triple points, variations in the P-T vaporization curve, interface width, and surface tension) are more sensitive to changes in the attractive softness than to the repulsive one. Understanding the different roles of attractive and repulsive forces on phase coexistence may contribute to developing more accurate models of liquids and their mixtures.

  3. Fluid-Phase Pinocytosis of Native Low Density Lipoprotein Promotes Murine M-CSF Differentiated Macrophage Foam Cell Formation

    Science.gov (United States)

    Xu, Qing; Bohnacker, Thomas; Wymann, Matthias P.; Kruth, Howard S.

    2013-01-01

    During atherosclerosis, low-density lipoprotein (LDL)-derived cholesterol accumulates in macrophages to form foam cells. Macrophage uptake of LDL promotes foam cell formation but the mechanism mediating this process is not clear. The present study investigates the mechanism of LDL uptake for macrophage colony-stimulating factor (M-CSF)-differentiated murine bone marrow-derived macrophages. LDL receptor-null (LDLR−/−) macrophages incubated with LDL showed non-saturable accumulation of cholesterol that did not down-regulate for the 24 h examined. Incubation of LDLR−/− macrophages with increasing concentrations of 125I-LDL showed non-saturable macrophage LDL uptake. A 20-fold excess of unlabeled LDL had no effect on 125I-LDL uptake by wild-type macrophages and genetic deletion of the macrophage scavenger receptors CD36 and SRA did not affect 125I-LDL uptake, showing that LDL uptake occurred by fluid-phase pinocytosis independently of receptors. Cholesterol accumulation was inhibited approximately 50% in wild-type and LDLR−/− mice treated with LY294002 or wortmannin, inhibitors of all classes of phosphoinositide 3-kinases (PI3K). Time-lapse, phase-contrast microscopy showed that macropinocytosis, an important fluid-phase uptake pathway in macrophages, was blocked almost completely by PI3K inhibition with wortmannin. Pharmacological inhibition of the class I PI3K isoforms alpha, beta, gamma or delta did not affect macrophage LDL-derived cholesterol accumulation or macropinocytosis. Furthermore, macrophages from mice expressing kinase-dead class I PI3K beta, gamma or delta isoforms showed no decrease in cholesterol accumulation or macropinocytosis when compared with wild-type macrophages. Thus, non-class I PI3K isoforms mediated macropinocytosis in these macrophages. Further characterization of the components necessary for LDL uptake, cholesterol accumulation, and macropinocytosis identified dynamin, microtubules, actin, and vacuolar type H(+)-ATPase as

  4. Mathematical modeling of planar and spherical vapor–liquid phase interfaces for multicomponent fluids

    Directory of Open Access Journals (Sweden)

    Celný David

    2016-01-01

    Full Text Available Development of methods for accurate modeling of phase interfaces is important for understanding various natural processes and for applications in technology such as power production and carbon dioxide separation and storage. In particular, prediction of the course of the non-equilibrium phase transition processes requires knowledge of the properties of the strongly curved phase interfaces of microscopic droplets. In our work, we focus on the spherical vapor–liquid phase interfaces for binary mixtures. We developed a robust computational method to determine the density and concentration profiles. The fundamentals of our approach lie in the Cahn-Hilliard gradient theory, allowing to transcribe the functional formulation into a system of ordinary Euler-Langrange equations. This system is then split and modified into a shape suitable for iterative computation. For this task, we combine the Newton-Raphson and the shooting methods providing a good convergence speed. For the thermodynamic roperties, the PC–SAFT equation of state is used. We determine the density and concentration profiles for spherical phase interfaces at various saturation factors for the binary mixture of CO2 and C9H20. The computed concentration profiles allow to the determine the work of formation and other characteristics of the microscopic droplets.

  5. Two-Phase Fluid Simulation Using a Diffuse Interface Model with Peng--Robinson Equation of State

    KAUST Repository

    Qiao, Zhonghua

    2014-01-01

    In this paper, two-phase fluid systems are simulated using a diffusive interface model with the Peng-Robinson equation of state (EOS), a widely used realistic EOS for hydrocarbon fluid in the petroleum industry. We first utilize the gradient theory of thermodynamics and variational calculus to derive a generalized chemical equilibrium equation, which is mathematically a second-order elliptic partial differential equation (PDE) in molar density with a strongly nonlinear source term. To solve this PDE, we convert it to a time-dependent parabolic PDE with the main interest in its final steady state solution. A Lagrange multiplier is used to enforce mass conservation. The parabolic PDE is then solved by mixed finite element methods with a semi-implicit time marching scheme. Convex splitting of the energy functional is proposed to construct this time marching scheme, where the volume exclusion effect of an EOS is treated implicitly while the pairwise attraction effect of EOS is calculated explicitly. This scheme is proved to be unconditionally energy stable. Our proposed algorithm is able to solve successfully the spatially heterogeneous two-phase systems with the Peng-Robinson EOS in multiple spatial dimensions, the first time in the literature. Numerical examples are provided with realistic hydrocarbon components to illustrate the theory. Furthermore, our computational results are compared with laboratory experimental data and verified with the Young-Laplace equation with good agreement. This work sets the stage for a broad extension of efficient convex-splitting semi-implicit schemes for numerical simulation of phase field models with a realistic EOS in complex geometries of multiple spatial dimensions.

  6. Observation of Droplet Size Oscillations in a Two-Phase Fluid under Shear Flow

    Science.gov (United States)

    Courbin, Laurent; Panizza, Pascal; Salmon, Jean-Baptiste

    2004-01-01

    Experimental observations of droplet size sustained oscillations are reported in a two-phase flow between a lamellar and a sponge phase. Under shear flow, this system presents two different steady states made of monodisperse multilamellar droplets, separated by a shear-thinning transition. At low and high shear rates, the droplet size results from a balance between surface tension and viscous stress, whereas for intermediate shear rates it becomes a periodic function of time. A possible mechanism for such kinds of oscillations is discussed.

  7. Phase autowaves in the near-electrode layer in the electrochemical cell with a magnetic fluid

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, V.V.; Kandaurova, N.V., E-mail: candaur18@yandex.ru; Chekanov, V.S.

    2017-06-01

    A change in color of the thin pellicle when light is reflected from the surface of the magnetic fluid at the interface with the transparent electrode in the electric field was observed. The formation of variable thickness near-electrode layer leads to a change in the spectrum of the reflected light depending on the applied voltage. Autowaves, that were observed in the layer are a unique object for the study of self-organization process. - Highlights: • A change of the thin pellicle color in the electric field was observed. • Formation of layer leads to a change in the spectrum of reflected light. • Autowaves with the typical leading centers and spiral waves were observed.

  8. Observation of Droplet Size Oscillations in a Two Phase Fluid under Shear Flow

    Science.gov (United States)

    Courbin, Laurent; Panizza, Pascal

    2004-11-01

    It is well known that complex fluids exhibit strong couplings between their microstructure and the flow field. Such couplings may lead to unusual non linear rheological behavior. Because energy is constantly brought to the system, richer dynamic behavior such as non linear oscillatory or chaotic response is expected. We report on the observation of droplet size oscillations at fixed shear rate. At low shear rates, we observe two steady states for which the droplet size results from a balance between capillary and viscous stress. For intermediate shear rates, the droplet size becomes a periodic function of time. We propose a phenomenological model to account for the observed phenomenon and compare numerical results to experimental data.

  9. High-pressure fluid-phase equilibria: Experimental methods and systems investigated (2000-2004)

    DEFF Research Database (Denmark)

    Dohrn, Ralf; Peper, Stephanie; Fonseca, José

    2010-01-01

    As a part of a series of reviews, a compilation of systems for which high-pressure phase-equilibrium data were published between 2000 and 2004 is given. Vapor-liquid equilibria, liquid-liquid equilibria, vapor-liquid-liquid equilibria,solid-liquid equilibria, solid-vapor equilibria, solid-vapor-l...

  10. Focal junctions retard lateral movement and disrupt fluid phase connectivity in the plasma membrane

    DEFF Research Database (Denmark)

    Vind-Kezunovic, D.; Wojewodzka, U.; Gniadecki, R.

    2008-01-01

    ,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI-C-18:0), which specifically partitions to the liquid-disordered (L-d), non-raft phase, was also enriched in focal junctions and its mobility was slightly retarded. Cross-linking of GM(1) by CTB or raft aggregation by methyl...

  11. On the Interplay between Sedimentation and Phase Separation Phenomena in Two-Dimensional Colloidal Fluids

    Czech Academy of Sciences Publication Activity Database

    Archer, J.A.; Malijevský, Alexandr

    2011-01-01

    Roč. 109, 7-10 SI (2011), s. 1087-1099 ISSN 0026-8976 R&D Projects: GA AV ČR IAA400720710 Institutional research plan: CEZ:AV0Z40720504 Keywords : colloids * sedimentation * phase transitions Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.819, year: 2011

  12. Effects of elongation on the phase behavior of the Gay-Berne fluid

    Science.gov (United States)

    Brown, Julian T.; Allen, Michael P.; Martín del Río, Elvira; Miguel, Enrique De

    1998-06-01

    In this paper we present a computer simulation study of the phase behavior of the Gay-Berne liquid crystal model, concentrating on the effects of varying the molecular elongation κ. We study a range of length-to-width parameters 3moves to lower temperature until it falls below the I-SB coexistence line, around κ=3.4, where liquid-vapor coexistence proves hard to establish. The liquid-vapor critical point seems to be completely absent at κ=4.0. Another dramatic effect is the growth of a stable SA ``island'' in the phase diagram at elongations slightly above κ=3.0. The SA range extends to both higher and lower temperatures as κ is increased. Also as κ is increased, the I-N transition is seen to move to lower density (and pressure) at given temperature. The lowest temperature at which the nematic phase is stable does not vary dramatically with κ. On cooling, no SB-crystal transition can be identified in the equation of state for any of these elongations; we suggest that, on the basis of simulation evidence, SB and crystal are really the same phase for these models.

  13. Formation of organic solid phases in hydrocarbon reservoir fluids. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, S.I.; Lindeloff, N.; Stenby, E.H.

    1998-12-31

    The occurrence of solid phases during oil recovery is a potential problem. The present work has mainly been concerned with wax formation due to cooling of oils with a large paraffin content. 8 oils have been included in this project, although only a few of these have till now been subject to all the experimental techniques applied. The oils and wax fractions from these have been characterized using techniques such as GC-MS and Ftir. The goal has in part been to get a detailed description of the oil composition for use in model evaluation and development and in part to get a fundamental understanding of waxy oil properties and behaviour. A high pressure (200 bar) equipment has been developed for automatic detection of wax appearance using a filtration technique and laser light turbidimetry. The latter was found to be far superior to the filtration. The filtration was used to sample the incipient solid phase for characterization. However entrapment of liquid in the filters currently used have hampered this part. A number of model systems and one gas condensate have been investigated. The GC-MS procedure was found only to been able to detect molecules up to n-C45 and the group type analysis was not accurate enough for modelling purposes. Using Ftir it was obvious that incipient phases may contain very complex molecules (asphaltenes) which are not captured by GC-MS especially when fractionation is done using the acetone precipitation at elevated temperature. The latter fractionation procedure has been investigated thoroughly as a tool for understanding wax distribution etc. Within thermodynamic modelling a delta lattice parameter model has been developed which incorporates the non-ideality of the solid phases into the calculation of SLE. The non-ideality is estimated from pure component properties. A new algorithm for phase equilibria involving gas-liquid-solid has been developed. Currently both the model work and the experimental works are continued. (au)

  14. Coupled Model for CO2 Leaks from Geological Storage: Geomechanics, Fluid Flow and Phase Transitions

    Science.gov (United States)

    Gor, G.; Prevost, J.

    2013-12-01

    Deep saline aquifers are considered as a promising option for long-term storage of carbon dioxide. However, risk of CO2 leakage from the aquifers through faults, natural or induced fractures or abandoned wells cannot be disregarded. Therefore, modeling of various leakage scenarios is crucial when selecting a site for CO2 sequestration and choosing proper operational conditions. Carbon dioxide is injected into wells at supercritical conditions (t > 31.04 C, P > 73.82 bar), and these conditions are maintained in the deep aquifers (at 1-2 km depth) due to hydrostatic pressure and geothermal gradient. However, if CO2 and brine start to migrate from the aquifer upward, both pressure and temperature will decrease, and at the depth of 500-750 m, the conditions for CO2 will become subcritical. At subcritical conditions, CO2 starts boiling and the character of the flow changes dramatically due to appearance of the third (vapor) phase and latent heat effects. When modeling CO2 leaks, one needs to couple the multiphase flow in porous media with geomechanics. These capabilities are provided by Dynaflow, a finite element analysis program [1]; Dynaflow has already showed to be efficient for modeling caprock failure causing CO2 leaks [2, 3]. Currently we have extended the capabilities of Dynaflow with the phase transition module, based on two-phase and three-phase isenthalpic flash calculations [4]. We have also developed and implemented an efficient method for solving heat and mass transport with the phase transition using our flash module. Therefore, we have developed a robust tool for modeling CO2 leaks. In the talk we will give a brief overview of our method and illustrate it with the results of simulations for characteristic test cases. References: [1] J.H. Prevost, DYNAFLOW: A Nonlinear Transient Finite Element Analysis Program. Department of Civil and Environmental Engineering, Princeton University, Princeton, NJ. http://www.princeton.edu/~dynaflow/ (last update 2013

  15. Single-phase CFD applicability for estimating fluid hot-spot locations in a 5 x 5 fuel rod bundle

    International Nuclear Information System (INIS)

    Ikeda, Kazuo; Makino, Yasushi; Hoshi, Masaya

    2006-01-01

    High-thermal performance PWR spacer grids require both of low pressure loss and high critical heat flux (CHF) properties. Therefore, a numerical study using computational fluid dynamics (CFD) was carried out to estimate pressure loss in strap and mixing vane structures. Moreover, a CFD simulation under single-phase flow condition was conducted for one specific condition in a water departure from nucleate boiling (DNB) test to examine the applicability of the CFD model for predicting the CHF rod position. Energy flux around the rod surface in a water DNB test is the sum of the intrinsic energy flux from a rod and the extrinsic energy flux from other rods, and increments of the enthalpy and decrements of flow velocity near the rod surface are assumed to affect CHF performance. CFD makes it possible to model the complicated flow field consisting of a spacer grid and a rod bundle and evaluate the local velocity and enthalpy distribution around the rod surface, which are assumed to determine the initial conditions for the two-phase structure. The results of this study indicate that single-phase CFD can play a significant role in designing PWR spacer grids for improved CHF performance

  16. Determining solid-fluid interface temperature distribution during phase change of cryogenic propellants using transient thermal modeling

    Science.gov (United States)

    Bellur, K.; Médici, E. F.; Hermanson, J. C.; Choi, C. K.; Allen, J. S.

    2018-04-01

    Control of boil-off of cryogenic propellants is a continuing technical challenge for long duration space missions. Predicting phase change rates of cryogenic liquids requires an accurate estimation of solid-fluid interface temperature distributions in regions where a contact line or a thin liquid film exists. This paper described a methodology to predict inner wall temperature gradients with and without evaporation using discrete temperature measurements on the outer wall of a container. Phase change experiments with liquid hydrogen and methane in cylindrical test cells of various materials and sizes were conducted at the Neutron Imaging Facility at the National Institute of Standards and Technology. Two types of tests were conducted. The first type of testing involved thermal cycling of an evacuated cell (dry) and the second involved controlled phase change with cryogenic liquids (wet). During both types of tests, temperatures were measured using Si-diode sensors mounted on the exterior surface of the test cells. Heat is transferred to the test cell by conduction through a helium exchange gas and through the cryostat sample holder. Thermal conduction through the sample holder is shown to be the dominant mode with the rate of heat transfer limited by six independent contact resistances. An iterative methodology is employed to determine contact resistances between the various components of the cryostat stick insert, test cell and lid using the dry test data. After the contact resistances are established, inner wall temperature distributions during wet tests are calculated.

  17. A multilevel simulation approach to derive the slip boundary condition of the solid phase in two-fluid models

    Science.gov (United States)

    Feng, Zhi-Gang; Michaelides, Efstathios; Mao, Shaolin

    2011-11-01

    The simulation of particulate flows for industrial applications often requires the use of a two-fluid model (TFM), where the solid particles are considered as a separate continuous phase. One of the underlining uncertainties in the use of aTFM in multiphase computations comes from the boundary condition of the solid phase. The no-slip condition at a solid boundary is not a valid assumption for the solid phase. Instead, several researchers advocate a slip condition as a more appropriate boundary condition. However, the question on the selection of an exact slip length or a slip velocity coefficient is still unanswered. In the present work we propose a multilevel simulation approach to compute the slip length that is applicable to a TFM. We investigate the motion of a number of particles near a vertical solid wall, while the particles are in fluidization using a direct numerical simulation (DNS); the positions and velocities of the particles are being tracked and analyzed at each time step. It is found that the time- and vertical-space averaged values of the particle velocities converge, yielding velocity profiles that can be used to deduce the particle slip length close to a solid wall. This work was supported by a grant from the DOE-NETL (DE-NT0008064) and by a grant from NSF (HRD-0932339).

  18. Fluid phase passivation and polymer encapsulation of InP/InGaAs heterojunction bipolar transistors

    International Nuclear Information System (INIS)

    Oxland, R K; Rahman, F

    2008-01-01

    This paper reports on the development of effective passivation techniques for improving and stabilizing the characteristics of InP/InGaAs heterojunction bipolar transistors. Two different methods for carrying out sulfur-based surface passivations are compared. These include exposure to gaseous hydrogen sulfide and immersion treatment in an ammonium sulfide solution. The temporal behaviour of effects resulting from such passivation treatments is reported. It is shown that liquid phase passivation has a larger beneficial effect on device performance than gas phase passivation. This is explained in terms of the polarity of passivating species and the exposed semiconductor surface. Finally, device encapsulation in a novel chalcogenide polymer is shown to be effective in preserving the benefits of surface passivation treatments. The relevant properties of this encapsulation material are also discussed

  19. Effect of phase transition on QGP fluid in ultra-relativistic heavy ion collision

    International Nuclear Information System (INIS)

    Nonaka, Chiho; Miyamura, Osamu; Muroya, Shin

    2001-01-01

    A full (3+1)-dimensional calculation using the Lagrangian hydrodynamics is proposed for relativistic nuclear collisions. The calculation enables us to evaluate anisotropic flow of hot and dense matter which appears in non-central and/or asymmetrical relativistic nuclear collisions. The relativistic hydrodynamical model is related to the equation of the state and the useful for the verification of quark-gluon plasma state. By virtue of the Lagrangian hydrodynamics we can easily trace the trajectory which corresponds to the adiabatic paths in the T-μ plane. We evaluate the directly of the influence of the phase transition to physical phenomena in the ultra-relativistic nuclear collisions. Using our relativistic hydrodynamical model, we discuss the effect of the phase transition on the collective flow. (author)

  20. Use of a solid-phase radioimmunoassay and formalin-fixed whole bacterial antigen in the detection of antigen-specific immunoglobulin in prostatic fluid.

    OpenAIRE

    Shortliffe, L M; Wehner, N; Stamey, T A

    1981-01-01

    The prostatic fluid of two patients with Escherichia coli bacterial prostatitis was analyzed for evidence of a local immune response to bacterial infection. A solid-phase radioimmunoassay was modified to measure the immunoglobulin (Ig)A and IgG antigen-specific antibody responses to infecting bacteria in serum and prostatic fluid from patient. Formalin-fixed whole E. coli were used as antigen. In one patient with acute E. coli prostatic infection, measurements of antigen-specific antibody con...

  1. Two-phase fluid flow measurements in small diameter channels using real-time neutron radiography

    International Nuclear Information System (INIS)

    Carlisle, B.S.; Johns, R.C.; Hassan, Y.A.

    2004-01-01

    A series of real-time, neutron radiography, experiments are ongoing at the Texas A and M Nuclear Science Center Reactor (NSCR). These tests determine the resolving capabilities for radiographic imaging of two phase water and air flow regimes through small diameter flow channels. Though both film and video radiographic imaging is available, the real-time video imaging was selected to capture the dynamic flow patterns with results that continue to improve. (author)

  2. Efficiency in supercritical fluid chromatography with different superficially porous and fully porous particles ODS bonded phases.

    Science.gov (United States)

    Lesellier, E

    2012-03-09

    The chromatographic efficiency, in terms of plate number per second, was dramatically improved by the introduction of sub-two microns particles with ultra-high pressure liquid chromatography (UHPLC). On the other hand, the recent development of superficially porous particles, called core-shell or fused-core particles, appears to allow the achievement of the same efficiency performances at higher speed without high pressure drops. CO₂-based mobile phases exhibiting much lower viscosities than aqueous based mobile phases allow better theoretical efficiencies, even with 3-5 μm particles, but with relative low pressure drops. They also allow much higher flow rates or much longer columns while using conventional instruments capable to operate below 400 bar. Moreover, the use of superficially porous particles in SFC could enhance the chromatographic performances even more. The kinetic behavior of ODS phases bonded on these particles was studied, with varied flow rates, outlet (and obviously inlet) pressures, temperatures, by using a homologous series (alkylbenzenes) with 10% modifier (methanol or acetonitrile) in the carbon dioxide mobile phase. Results were also compared with classical fully porous particles, having different sizes, from 2.5 to 5 μm. Superior efficiency (N) and reduced h were obtained with these new ODS-bonded particles in regards to classical ones, showing their great interest for use in SFC. However, surprising behavior were noticed, i.e. the increase of the theoretical plate number vs. the increase of the chain length of the compounds. This behavior, opposite to the one classically reported vs. the retention factor, was not depending on the outlet pressure, but on the flow rate and the temperature changes. The lower radial trans-column diffusion on this particle types could explain these results. This diffusion reduction with these ODS-bonded superficially porous particles seems to decrease with the increase of the residence time of compounds

  3. Study of three-phase fluid dynamics in a surging production system

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Rodolfo; Assuncao, Pablo Morelato; Ressel, Fabio de Assis [Universidade Federal do Espirito Santo, Sao Mateus, ES (Brazil)

    2010-07-01

    Among others factors, petroleum extraction is subordinate to the reservoir pressure and the required pressure to rise it to the surface production facilities. Reservoir deliverability equations tied production rate with reservoir driving force (Economides, 1994). The Inflow Performance Relationship (IPR) is obtained by measuring the production rates under various drawdown pressures, and is used to assess well performance by plotting the well production rate against the flowing bottonhole pressure. Others limiting rate of production factors are imposed by wellhead required pressure and the production tubing performance. The tubing performance is sensitive to several parameters among which we can highlight the production tubing geometry and the properties of the produced fluids (Guo, 2007). Therewith we can define the Tubing Performance Relationship (TPR) similarly to the IPR. Thus the present work aims the hydraulic performance analysis of a production system with a flowing well without artificial elevation methods. Furthermore the triphasic (water-oil-gas) flow studies, both in the production string and the production line, allowed the inspection of the main variables of the system, fluid properties, operation conditions and geometric parameters, on the head loss. In order obtain all these, several methods were developed, each one with specifics limitations to include all flow patterns. The most common biphasic horizontal flow patterns according to Brill and Beggs (1975) are: mist flow, bubble flow, plug flow, slug flow, stratified flow, wavy flow and annular flow. Yet according to Brill and Beggs (1975) the most common biphasic vertical flow patterns are: bubbly flow, slug flow, churn flow, and annular flow. Accordingly to these, another outbreak discussed is the pattern flow sensibility on the head loss. The methodology used in the present work is based on the discretization of the system in several discrete counterparts cells, in which was where it was applied

  4. A stochastic asymptotic-preserving scheme for a kinetic-fluid model for disperse two-phase flows with uncertainty

    Energy Technology Data Exchange (ETDEWEB)

    Jin, Shi, E-mail: sjin@wisc.edu [Department of Mathematics, University of Wisconsin–Madison, Madison, WI 53706 (United States); Institute of Natural Sciences, School of Mathematical Science, MOELSEC and SHL-MAC, Shanghai Jiao Tong University, Shanghai 200240 (China); Shu, Ruiwen, E-mail: rshu2@math.wisc.edu [Department of Mathematics, University of Wisconsin–Madison, Madison, WI 53706 (United States)

    2017-04-15

    In this paper we consider a kinetic-fluid model for disperse two-phase flows with uncertainty. We propose a stochastic asymptotic-preserving (s-AP) scheme in the generalized polynomial chaos stochastic Galerkin (gPC-sG) framework, which allows the efficient computation of the problem in both kinetic and hydrodynamic regimes. The s-AP property is proved by deriving the equilibrium of the gPC version of the Fokker–Planck operator. The coefficient matrices that arise in a Helmholtz equation and a Poisson equation, essential ingredients of the algorithms, are proved to be positive definite under reasonable and mild assumptions. The computation of the gPC version of a translation operator that arises in the inversion of the Fokker–Planck operator is accelerated by a spectrally accurate splitting method. Numerical examples illustrate the s-AP property and the efficiency of the gPC-sG method in various asymptotic regimes.

  5. Numerical simulation of transient, adiabatic, two-dimensional two-phase flow using the two-fluid model

    International Nuclear Information System (INIS)

    Neves Conti, T. das.

    1983-01-01

    A numerical method is developed to simulate adiabatic, transient, two-dimensional two-phase flow. The two-fluid model is used to obtain the mass and momentum conservation equations. These are solved by an iterative algorithm emphoying a time-marching scheme. Based on the corrective procedure of Hirt and Harlow a poisson equation is derived for the pressure field. This equation is finite-differenced and solved by a suitable matrix inversion technique. In the absence of experiment results several numerical tests were made in order to chec accuracy, convergence and stability of the proposed method. Several tests were also performed to check whether the behavior of void fraction and phasic velocities conforms with previous observations. (Author) [pt

  6. Density functional formulation of the random-phase approximation for inhomogeneous fluids: Application to the Gaussian core and Coulomb particles.

    Science.gov (United States)

    Frydel, Derek; Ma, Manman

    2016-06-01

    Using the adiabatic connection, we formulate the free energy in terms of the correlation function of a fictitious system, h_{λ}(r,r^{'}), in which interactions λu(r,r^{'}) are gradually switched on as λ changes from 0 to 1. The function h_{λ}(r,r^{'}) is then obtained from the inhomogeneous Ornstein-Zernike equation and the two equations constitute a general liquid-state framework for treating inhomogeneous fluids. The two equations do not yet constitute a closed set. In the present work we use the closure c_{λ}(r,r^{'})≈-λβu(r,r^{'}), known as the random-phase approximation (RPA). We demonstrate that the RPA is identical with the variational Gaussian approximation derived within the field-theoretical framework, originally derived and used for charged particles. We apply our generalized RPA approximation to the Gaussian core model and Coulomb charges.

  7. Influence of liquid phase on nanoparticle-based giant electrorheological fluid.

    Science.gov (United States)

    Gong, Xiuqing; Wu, Jinbo; Huang, Xianxiang; Wen, Weijia; Sheng, Ping

    2008-04-23

    We show that the chemical structures of silicone oils can have an important role in the giant electrorheological (GER) effect. The interaction between silicone oils and solid nanoparticles is found to significantly influence the ER effect. By increasing the kinematic viscosity of silicone oils, which is a function of siloxane chain length, sol-like, gel-like and clay-like appearances of the constituted ER fluids were observed. Different functional-group-terminated silicone oils were also employed as the dispersing media. Significant differences of yield stress were found. We systematically study the effect of siloxane chain lengths on the permeability of oils traveling through the porous spaces between the particles (using the Washburn method), oils adsorbed on the particles' surface (using FT-IR spectra), as well as their particle size distribution (using dynamic light scattering). Our results indicate the hydrogen bonds are instrumental in linking the silicone oil to GER solid particles, and long chain lengths can enhance the agglomeration of the GER nanoparticles to form large clusters. An optimal oil structure, with hydroxyl-terminated silicone oil and a suitable viscosity, was chosen which can create the highest yield stress of ∼300 kPa under a 5 kV mm(-1) DC electric field.

  8. Strong cation exchange-type chiral stationary phase for enantioseparation of chiral amines in subcritical fluid chromatography.

    Science.gov (United States)

    Wolrab, Denise; Kohout, Michal; Boras, Mario; Lindner, Wolfgang

    2013-05-10

    A new strong cation exchange type chiral stationary phase (SCX CSP) based on a syringic acid amide derivative of trans-(R, R)-2-aminocyclohexanesulfonic acid was applied to subcritical fluid chromatography (SFC) for separation of various chiral basic drugs and their analogues. Mobile phase systems consisting of aliphatic alcohols as polar modifiers and a broad range of amines with different substitution patterns and lipophilicity were employed to evaluate the impact on the SFC retention and selectivity characteristics. The observed results point to the existence of carbonic and carbamic acid salts formed as a consequence of reactions occurring between carbon dioxide, the alcoholic modifiers and the amine species present in the sub/supercritical fluid medium, respectively. Evidence is provided that these species are essential for affecting ion exchange between the strongly acidic chiral selector units and the basic analytes, following the well-established stoichiometric displacement mechanisms. Specific trends were observed when different types of amines were used as basic additives. While ammonia gave rise to the formation of the most strongly eluting carbonic and carbamic salt species, simple tertiary amines consistently provided superior levels of enantioselectivity. Furthermore, trends in the chiral SFC separation characteristics were investigated by the systematic variation of the modifier content and temperature. Different effects of additives are interpreted in terms of changes in the relative concentration of the transient ionic species contributing to analyte elution, with ammonia-derived carbamic salts being depleted at elevated temperatures by decomposition. Additionally, in an effort to optimize SFC enantiomer separation conditions for selected analytes, the impact of the type of the organic modifier, temperature, flow rate and active back pressure were also investigated. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. Thermodynamic analysis of a thermal storage unit under the influence of nano-particles added to the phase change material and/or the working fluid

    Science.gov (United States)

    Abolghasemi, Mehran; Keshavarz, Ali; Mehrabian, Mozaffar Ali

    2012-11-01

    The thermal storage unit consists of two concentric cylinders where the working fluid flows through the internal cylinder and the annulus is filled with a phase change material. The system carries out a cyclic operation; each cycle consists of two processes. In the charging process the hot working fluid enters the internal cylinder and transfers heat to the phase change material. In the discharging process the cold working fluid enters the internal cylinder and absorbs heat from the phase change material. The differential equations governing the heat transfer between the two media are solved numerically. The numerical results are compared with the experimental results available in the literature. The performance of an energy storage unit is directly related to the thermal conductivity of nano-particles. The energy consumption of a residential unit whose energy is supplied by a thermal storage system can be reduced by 43 % when using nano-particles.

  10. Evaluation of the thermal performance of a solar water heating thermosyphon versus a two-phase closed thermosyphon using different working fluids

    Energy Technology Data Exchange (ETDEWEB)

    Ordaz-Flores, A. [Posgrado en Ingenieria (Energia), Univ. Nacional Autonoma de Mexico, Temixco, Morelos (Mexico); Garcia-Valladares, O.; Gomez, V.H. [Centro de Investigacion en Energia, Univ. Nacional Autonoma de Mexico, Temixco, Morelos (Mexico)

    2008-07-01

    A water heating closed two-phase thermosyphon solar system was designed and built. The system consists of a flat plate solar collector coupled to a thermotank by a continuous copper tubing in which the working fluid circulates. The working fluid evaporates in the collector and condensates in the thermotank transferring its latent heat to the water through a coil heat exchanger. The tested fluids are acetone and R134a. The thermal performance of the proposed systems is compared with a conventional solar water thermosyphon under the same operating conditions. Advantages of a two-phase system include the elimination of freezing, fouling, scaling and corrosion. Geometry and construction materials are the same except for the closed circuit presented in the two-phase system. Data were collected from temperature and pressure sensors throughout the two systems. Early results suggest that R134a may provide a better performance than acetone for this kind of systems. (orig.)

  11. Fluid sensitive nanoscale switching with quantum levitation controlled by $\\alpha$-Sn/$\\beta$-Sn phase transition

    OpenAIRE

    Boström, Mathias; Dou, Maofeng; Malyi, Oleksandr I.; Parashar, Prachi; Parsons, Drew F.; Brevik, Iver; Persson, Clas

    2018-01-01

    We analyze the Lifshitz pressure between silica and tin separated by a liquid mixture of bromobenzene and chlorobenzene. We show that the phase transition from semimetallic α−Sn to metallic β−Sn can switch Lifshitz forces from repulsive to attractive. This effect is caused by the difference in dielectric functions of α−Sn and β−Sn, giving both attractive and repulsive contributions to the total Lifshitz pressure in different frequency regions controlled by the composition of the intervening l...

  12. Determination of parathion in biological fluids by means of direct Solid Phase Microextraction.

    OpenAIRE

    Gallardo, Eugenia; Barroso, Mário; Margalho, C.; Cruz, Angelines; Vieira, Duarte Nuno; López-Rivadulla, Manuel

    2010-01-01

    A new and simple procedure for the determination of parathion in human whole blood and urine using direct immersion (DI) solid-phase microextraction (SPME) and gas chromatography/mass spectrometry (GC/MS) is presented. This technique was developed using only 100 ìL of sample, and ethion was used as internal standard (IS). A 65-ìm Carbowax/divinylbenzene (CW/DVB) SPME fibre was selected for sampling, and the main parameters affecting the SPME process such as extraction ...

  13. Sequential, solid-phase assay for biotin in physiologic fluids that correlates with expected biotin status

    International Nuclear Information System (INIS)

    Mock, D.M.; DuBois, D.B.

    1986-01-01

    Interest in accurate measurement of biotin concentrations in plasma and urine has been stimulated by recent advances in the understanding of biotin-responsive inborn errors of metabolism and by several reports describing acquired biotin deficiency during parenteral alimentation. This paper presents a biotin assay utilizing radiolabeled avidin in a sequential, solid-phase method; the assay has increased sensitivity compared to previous methods (greater than or equal to 10 fmol/tube), correlates with expected trends in biotin concentrations in blood and urine in a rat model of biotin deficiency, and can utilize commercially available radiolabeled avidin

  14. Magmatic Vapor Phase Transport of Copper in Reduced Porphyry Copper-Gold Deposits: Evidence From PIXE Microanalysis of Fluid Inclusions

    Science.gov (United States)

    Rowins, S. M.; Yeats, C. J.; Ryan, C. G.

    2002-05-01

    Nondestructive proton-induced X-ray emission (PIXE) studies of magmatic fluid inclusions in granite-related Sn-W deposits [1] reveal that copper transport out of reduced felsic magmas is favored by low-salinity vapor and not co-existing high-salinity liquid (halite-saturated brine). Copper transport by magmatic vapor also has been documented in oxidized porphyry Cu-Au deposits, but the magnitude of Cu partitioning into the vapor compared to the brine generally is less pronounced than in the reduced magmatic Sn-W systems [2]. Consideration of these microanalytical data leads to the hypothesis that Cu and, by inference, Au in the recently established "reduced porphyry copper-gold" (RPCG) subclass should partition preferentially into vapor and not high-salinity liquid exsolving directly from fluid-saturated magmas [3-4]. To test this hypothesis, PIXE microanalysis of primary fluid inclusions in quartz-sulfide (pyrite, pyrrhotite & chalcopyrite) veins from two RPCG deposits was undertaken using the CSIRO-GEMOC nuclear microprobe. PIXE microanalysis for the ~30 Ma San Anton deposit (Mexico) was done on halite-saturated aqueous brine (deposit (W. Australia) was done on halite-saturated "aqueous" inclusions, which contain a small (deposits of the new RPCG subclass demonstrate the greater potential of these systems, compared to the classically oxidized porphyry Cu-Au systems, to transport Cu and probably precious metals in a magmatic aqueous vapor phase. These PIXE data also support the possibility that Cu partitions preferentially into an immiscible CO2-rich magmatic fluid. References: [1] Heinrich, C.A. et al. (1992) Econ. Geol., 87, 1566-1583. [2] Heinrich, C.A. et al. (1999) Geology, 27, 755-758. [3] Rowins, S.M. (2000) Geology, 28, 491-494. [4] Rowins, S.M. (2000) The Gangue, GAC-MDD Newsletter, 67, 1-7 (www.gac.ca). [5] Rowins, S.M. et al. (1993) Geol. Soc. Australia Abs., 34, 68-70.

  15. Computational Fluid Dynamics Simulations of Gas-Phase Radial Dispersion in Fixed Beds with Wall Effects

    Directory of Open Access Journals (Sweden)

    Anthony G. Dixon

    2017-10-01

    Full Text Available The effective medium approach to radial fixed bed dispersion models, in which radial dispersion of mass is superimposed on axial plug flow, is based on a constant effective dispersion coefficient, DT. For packed beds of a small tube-to-particle diameter ratio (N, the experimentally-observed decrease in this parameter near the tube wall is accounted for by a lumped resistance located at the tube wall, the wall mass transfer coefficient km. This work presents validated computational fluid dynamics (CFD simulations to obtain detailed radial velocity and concentration profiles for eight different computer-generated packed tubes of spheres in the range 5.04 ≤ N ≤ 9.3 and over a range of flow rates 87 ≤ Re ≤ 870 where Re is based on superficial velocity and the particle diameter dp. Initial runs with pure air gave axial velocity profiles vz(r averaged over the length of the packing. Then, simulations with the tube wall coated with methane yielded radial concentration profiles. A model with only DT could not describe the radial concentration profiles. The two-parameter model with DT and km agreed better with the bed-center concentration profiles, but not with the sharp decreases in concentration close to the tube wall. A three-parameter model based on classical two-layer mixing length theory, with a wall-function for the decrease in transverse radial convective transport in the near-wall region, showed greatly improved ability to reproduce the near-wall concentration profiles.

  16. Nonideal mixing of phosphatidylserine and phosphatidylcholine in the fluid lamellar phase.

    Science.gov (United States)

    Huang, J; Swanson, J E; Dibble, A R; Hinderliter, A K; Feigenson, G W

    1993-02-01

    The mixing of phosphatidylserine (PS) and phosphatidylcholine (PC) in fluid bilayer model membranes was studied by measuring binding of aqueous Ca2+ ions. The measured [Ca2+]aq was used to derive the activity coefficient for PS, gamma PS, in the lipid mixture. For (16:0, 18:1) PS in binary mixtures with either (16:0, 18:1)PC, (14:1, 14:1)PC, or (18:1, 18:1)PC, gamma PS > 1; i.e., mixing is nonideal, with PS and PC clustered rather than randomly distributed, despite the electrostatic repulsion between PS headgroups. To understand better this mixing behavior, Monte Carlo simulations of the PS/PC distributions were performed, using Kawasaki relaxation. The excess energy was divided into an electrostatic term Uel and one adjustable term including all other nonideal energy contributions, delta Em. Uel was calculated using a discrete charge theory. Kirkwood's coupling parameter method was used to calculate the excess free energy of mixing, delta GEmix, hence In gamma PS,calc. The values of In gamma PS,calc were equalized by adjusting delta Em in order to find the simulated PS/PC distribution that corresponded to the experimental results. We were thus able to compare the smeared charge calculation of [Ca2+]surf with a calculation ("masked evaluation method") that recognized clustering of the negatively charged PS: clustering was found to have a modest effect on [Ca2+]surf, relative to the smeared charge model. Even though both PS and PC tend to cluster, the long-range nature of the electrostatic repulsion reduces the extent of PS clustering at low PS mole fraction compared to PC clustering at an equivalent low PC mole fraction.

  17. Interacting cosmic fluids and phase transitions under a holographic modeling for dark energy

    Energy Technology Data Exchange (ETDEWEB)

    Lepe, Samuel [Pontificia Universidad Catolica de Valparaiso, Instituto de Fisica, Facultad de Ciencias, Valparaiso (Chile); Pena, Francisco [Universidad de La Frontera, Departamento de Ciencias Fisicas, Facultad de Ingenieria y Ciencias, Temuco (Chile)

    2016-09-15

    We discuss the consequences of possible sign changes of the Q-function which measures the transfer of energy between dark energy and dark matter. We investigate this scenario from a holographic perspective by modeling dark energy by a linear parametrization and CPL-parametrization of the equation of state (ω). By imposing the strong constraint of the second law of thermodynamics, we show that the change of sign for Q, due to the cosmic evolution, imply changes in the temperatures of dark energy and dark matter. We also discuss the phase transitions, in the past and future, experienced by dark energy and dark matter (or, equivalently, the sign changes of their heat capacities). (orig.)

  18. Heating of a fully saturated darcian half-space: Pressure generation, fluid expulsion, and phase change

    Science.gov (United States)

    Delaney, P.

    1984-01-01

    Analytical solutions are developed for the pressurization, expansion, and flow of one- and two-phase liquids during heating of fully saturated and hydraulically open Darcian half-spaces subjected to a step rise in temperature at its surface. For silicate materials, advective transfer is commonly unimportant in the liquid region; this is not always the case in the vapor region. Volume change is commonly more important than heat of vaporization in determining the position of the liquid-vapor interface, assuring that the temperatures cannot be determined independently of pressures. Pressure increases reach a maximum near the leading edge of the thermal front and penetrate well into the isothermal region of the body. Mass flux is insensitive to the hydraulic properties of the half-space. ?? 1984.

  19. Interacting cosmic fluids and phase transitions under a holographic modeling for dark energy

    International Nuclear Information System (INIS)

    Lepe, Samuel; Pena, Francisco

    2016-01-01

    We discuss the consequences of possible sign changes of the Q-function which measures the transfer of energy between dark energy and dark matter. We investigate this scenario from a holographic perspective by modeling dark energy by a linear parametrization and CPL-parametrization of the equation of state (ω). By imposing the strong constraint of the second law of thermodynamics, we show that the change of sign for Q, due to the cosmic evolution, imply changes in the temperatures of dark energy and dark matter. We also discuss the phase transitions, in the past and future, experienced by dark energy and dark matter (or, equivalently, the sign changes of their heat capacities). (orig.)

  20. Energetics of the multi-phase fluid flow in a narrow kerf in laser cutting conditions

    Science.gov (United States)

    Golyshev, A. A.; Orishich, A. M.; Shulyatyev, V. B.

    2016-10-01

    The energy balance of the multi-phase medium flow is studied experimentally under the laser cutting. Experimental data are generalized due to the condition of minimal roughness of the created surface used as a quality criterion of the melt flow, and also due to the application of dimensionless parameters: Peclet number and dimensionless absorbed laser power. For the first time ever it is found that, regardless the assistant gas (oxygen or nitrogen), laser type (the fiber one with the wavelength of 1.07 µm or CO2-laser with the wavelength of 10.6 µm), the minimal roughness is provided at a certain energy input in a melt unit, about 26 J/mm3. With oxygen, 50% of this input is provided by the radiation, the other 50% - by the exothermic reaction of iron oxidation.

  1. Maximizing performance in supercritical fluid chromatography using low-density mobile phases.

    Science.gov (United States)

    Gritti, Fabrice; Fogwill, Michael; Gilar, Martin; Jarrell, Joseph A

    2016-10-14

    The performance of a 3.0mm×150mm column packed with 1.8μm fully porous HSS-SB-C 18 particles was investigated in supercritical fluid chromatography (SFC) with low-density, highly expansible carbon dioxide. These conditions are selected for the analysis of semi-volatile compounds. Elevated temperatures (>100°C) were then combined with low column back pressures (<100bar). In this work, the inlet temperature of pure carbon dioxide was set at 107°C, the active back pressure regulator (ABPR) pressure was fixed at 100bar, and the flow rate was set at 2.1mL/min at 12°C (liquefied carbon dioxide) and at an inlet column pressure close to 300bar. Nine n-alkylbenzenes (from benzene to octadecylbenzene) were injected under linear (no sample overload) conditions. The severe steepness of the temperature gradients across the column diameter were predicted from a simplified heat transfer model. Such conditions dramatically lower the column performance by affecting the symmetry of the peak shape. In order to cope with this problem, three different approaches were experimentally tested. They include (1) the decoupling and the proper selection of the inlet eluent temperature with respect to the oven temperature, (2) the partial thermal insulation of the column using polyethylene aerogel, and (3) the application of a high vacuum (10 -5 Torr provided by a turbo-molecular pump) in a housing chamber surrounding the whole column body. The results reveal that (1) the column efficiency can be maximized by properly selecting the difference between the eluent and the oven temperatures, (2) the mere wrapping of the column with an excellent insulating material is insufficient to fully eliminate heat exchanges by conduction and the undesirable radial density gradients across the column i.d., and (3) the complete thermal insulation of the SFC column under high vacuum allows to maximize the column efficiency by maintaining the integrity of the peak shape. Copyright © 2016 Elsevier B.V. All

  2. Dynamics of mineral crystallization at inclusion-garnet interface from precipitated slab-derived fluid phase: first in-situ synchrotron x-ray measurements

    Science.gov (United States)

    Malaspina, Nadia; Alvaro, Matteo; Campione, Marcello; Nestola, Fabrizio

    2015-04-01

    Remnants of the fluid phase at ultrahigh pressure (UHP) in subduction environments may be preserved as primary multiphase inclusions in UHP minerals. These inclusions are frequently hosted by minerals stable at mantle depths, such as garnet, and show the same textural features as fluid inclusions. The mineral infillings of the solid multiphase inclusions are generally assumed to have crystallized by precipitation from the solute load of dense supercritical fluids equilibrating with the host rock. Notwithstanding the validity of this assumption, the mode of crystallization of daughter minerals during precipitation within the inclusion and/or the mechanism of interaction between the fluid at supercritical conditions and the host mineral are still poorly understood from a crystallographic point of view. A case study is represented by garnet orthopyroxenites from the Maowu Ultramafic Complex (China) deriving from harzburgite precursors metasomatised at ~ 4 GPa, 750 °C by a silica- and incompatible trace element-rich fluid phase. This metasomatism produced poikilitic orthopyroxene and inclusion-rich garnet porphyroblasts. Solid multiphase primary inclusions in garnet display a size within a few tens of micrometers and negative crystal shapes. Infilling minerals (spinel: 10-20 vol.%; amphibole, chlorite, talc, mica: 80- 90 vol.%) occur with constant volume ratios and derive from trapped solute-rich aqueous fluids. To constrain the possible mode of precipitation of daughter minerals, we performed for the first time a single-crystal X-ray diffraction experiment by means of Synchrotron Radiation at DLS-Diamond Light Source. In combination with electron probe microanalyses, this measurement allowed the unique identification of each mineral phase and their reciprocal orientations. We demonstrated the epitaxial relationship between spinel and garnet and between some hydrous minerals. Epitaxy drives a first-stage nucleation of spinel under near-to-equilibrium conditions

  3. The Uhlenbeck-Ford model: Exact virial coefficients and application as a reference system in fluid-phase free-energy calculations

    Science.gov (United States)

    Paula Leite, Rodolfo; Freitas, Rodrigo; Azevedo, Rodolfo; de Koning, Maurice

    2016-11-01

    The Uhlenbeck-Ford (UF) model was originally proposed for the theoretical study of imperfect gases, given that all its virial coefficients can be evaluated exactly, in principle. Here, in addition to computing the previously unknown coefficients B11 through B13, we assess its applicability as a reference system in fluid-phase free-energy calculations using molecular simulation techniques. Our results demonstrate that, although the UF model itself is too soft, appropriately scaled Uhlenbeck-Ford (sUF) models provide robust reference systems that allow accurate fluid-phase free-energy calculations without the need for an intermediate reference model. Indeed, in addition to the accuracy with which their free energies are known and their convenient scaling properties, the fluid is the only thermodynamically stable phase for a wide range of sUF models. This set of favorable properties may potentially put the sUF fluid-phase reference systems on par with the standard role that harmonic and Einstein solids play as reference systems for solid-phase free-energy calculations.

  4. Two-phase pressurized thermal shock investigations using a 3D two-fluid modeling of stratified flow with condensation

    International Nuclear Information System (INIS)

    Yao, W.; Coste, P.; Bestion, D.; Boucker, M.

    2003-01-01

    In this paper, a local 3D two-fluid model for a turbulent stratified flow with/without condensation, which can be used to predict two-phase pressurized thermal shock, is presented. A modified turbulent K- model is proposed with turbulence production induced by interfacial friction. A model of interfacial friction based on a interfacial sublayer concept and three interfacial heat transfer models, namely, a model based on the small eddies controlled surface renewal concept (HDM, Hughes and Duffey, 1991), a model based on the asymptotic behavior of the Eddy Viscosity (EVM), and a model based on the Interfacial Sublayer concept (ISM) are implemented into a preliminary version of the NEPTUNE code based on the 3D module of the CATHARE code. As a first step to apply the above models to predict the two-phase thermal shock, the models are evaluated by comparison of calculated profiles with several experiments: a turbulent air-water stratified flow without interfacial heat transfer; a turbulent steam-water stratified flow with condensation; turbulence induced by the impact of a water jet in a water pool. The prediction results agree well with the experimental data. In addition, the comparison of three interfacial heat transfer models shows that EVM and ISM gave better prediction results while HDM highly overestimated the interfacial heat transfers compared to the experimental data of a steam water stratified flow

  5. Three-dimensional fluid mechanics of particulate two-phase flows in U-bend and helical conduits

    Science.gov (United States)

    Tiwari, Prashant; Antal, Steven P.; Podowski, Michael Z.

    2006-04-01

    The results of numerous studies performed to date have shown that the performance of various hydraulic systems can be significantly improved by using curved conduit geometries instead of straight tubes. In particular, the formation of Dean vortices, which enhance the development of centrifugal instabilities, has been identified as a factor behind reducing the near-wall concentration buildup in particulate flow devices (e.g., in membrane filtration modules). Still, several issues regarding the effect of conduit curvature on local multidimensional phenomena governing fluid flow still remain open. A related issue is concerned with the impact that conduit geometry makes on the concentration distribution of a dispersed phase in two-phase flows in general, and in particulate flows (solid/liquid or solid/gas suspensions) in particular. It turns out that only very limited efforts have been made in the past to understand the fluid mechanics of such flows via advanced computer simulations. The purpose of this paper is to present the results of full three-dimensional (3D) theoretical and numerical analyses of single- and two-phase dilute particle/liquid flows in U-bend and helical curved conduits. The numerical analysis is based on computational fluid dynamics (CFD) simulations performed using a state-of-the-art multiphase flow computer code, NPHASE. The major issues discussed in the first part of the paper are concerned with the effect of curved/coiled geometry on the evolution of flow field and the associated wall shear. It has been demonstrated that the primary curvature (a common factor for both the U-bend and helix geometries) may cause a substantial asymmetry in the radial distribution of the main flow velocity. This, in turn, leads to a significant, albeit highly nonuniform, increase in the wall shear stress. Specifically, the wall shear around the outer half of tube circumference may become twice the corresponding value for a straight tube, and gradually decrease to

  6. Two-phase flows during a discharge of liquefied gases, initially at saturation. Effect of the nature of the fluid; Ecoulements diphasiques lors de la vidange de gaz liquefies initialement a saturation. Influence de la nature du fluide

    Energy Technology Data Exchange (ETDEWEB)

    Alix, P.

    1997-10-03

    In the case of a confinement loss (breakage of a connection piece) on a pressurized liquefied gas tank, a critical two-phase (liquid-vapour) flow is generated. This thesis is aimed at the validation of models describing these flows with various fluids (water, R 11, methanol, ethyl acetate, pure butane, commercial butane), using a pilot experimental plant. Results show that reduced upstream pressure is the main parameter, thus indicating that a model can be validated using minimal fluids. The homogenous models DEM and HRM appear to be more precise

  7. Preparation and flow characteristic of a novel phase change fluid for latent heat transfer

    Energy Technology Data Exchange (ETDEWEB)

    Zou, Deqiu [Marine College of Ningbo University, Ningbo 315211, Zhejiang (China); Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640 (China); Feng, Ziping; Xiao, Rui; Qin, Kun; Zhang, Jianjun; Song, Wenji; Tu, Qiu [Guangzhou Institute of Energy Conversion, Chinese Academy of Sciences, Guangzhou 510640 (China)

    2010-12-15

    A novel phase change emulsion (PCE) was prepared and its latent heat was measured by DSC. To analyze its feasibility in heat transportation through a piping system, an experimental system was built. The pressure drop of the PCE for turbulent flow was measured and the effects of such facts as the paraffin concentration and flow velocity were discussed. According to the pressure characteristic and latent heat of the PCE, the pumping power consumption rates of PCE to water under the same pipe diameter and a given heat transportation quantity can be obtained. The results show that mass flow rate and pumping power consumption of the PCE decrease greatly compared with water. For example, the decrease can be up to about 73% at V=0.6 m/s (20 and 30 wt%). Furthermore, the results show that PCE of 20 wt% can obtain almost the same pumping power consumption savings as PCE of 30 wt% in a certain flow velocity range. Finally, the applications of the PCE in the area of waste heat usage, electrical boiler and solar energy usage were commented. (author)

  8. Prediction of fluid phase behaviors in a CO{sub 2}-EOR process in Weyburn Field, Saskatchewan, Canada

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, L.; Law, D.H.S. [Alberta Research Council, Edmonton, AB (Canada); Freitag, N.; Huang, S. [Saskatchewan Research Council, Regina, SK (Canada)

    2005-07-01

    The mechanisms of enhanced oil recovery (EOR) and carbon dioxide (CO{sub 2}) storage in an oil depleted reservoir are being studied at the International Energy Agency's (IEA) Weyburn CO2 Monitoring and Storage Project in Saskatchewan. One of the objectives of this multi-disciplinary project has been to develop a Pressure-Volume-Temperature (PVT) model for the CO{sub 2}-Weyburn oil system that can be coupled with compositional reservoir models for short- and long-term field-scale reservoir simulations. In order to assess the long term risk of carbon dioxide (CO{sub 2}) injection for the purpose of EOR, it is important to accurately predict the CO{sub 2} distribution in different phases in the reservoir (aqueous, oleic and gaseous). The newly developed seven-component PVT model for Weyburn oil was based on measurements of phase-behavior properties such as oil density, viscosity, gas-oil ratio, saturation pressure and minimum miscibility pressure from oil samples collected from wells in different parts of the reservoir. The Peng-Robinson equation of state was used for the PVT model development and CO{sub 2} solubility in water was described by Henry's Law. Estimations of mineral trapping, ionic trapping and solubility trapping of CO{sub 2} are based on the amount of CO{sub 2} stored in the aqueous phase, but the amount of CO{sub 2} stored in the gaseous phase, which is the most mobile phase of CO{sub 2} in the reservoir, is essential in the estimation of CO{sub 2} leakage. The model was continuously modified as the field process proceeded in order to identify the dynamic change in fluid properties and the effect of contaminants in the injecting CO{sub 2}. The model, coupled with a compositional reservoir model, was used to predict the CO{sub 2} distribution and storage performance in the Weyburn field. 2 refs., 4 tabs., 8 figs.

  9. A highly self-adaptive cold plate for the single-phase mechanically pumped fluid loop for spacecraft thermal management

    International Nuclear Information System (INIS)

    Wang, Ji-Xiang; Li, Yun-Ze; Zhang, Hong-Sheng; Wang, Sheng-Nan; Liang, Yi-Hao; Guo, Wei; Liu, Yang; Tian, Shao-Ping

    2016-01-01

    Highlights: • A highly self-adaptive cold plate integrated with paraffin-based actuator is proposed. • Higher operating economy is attained due to an energy-efficient strategy. • A greater compatibility of the current space control system is obtained. • Model was entrenched theoretically to design the system efficiently. • A strong self-adaptability of the cold plate is observed experimentally. - Abstract: Aiming to improve the conventional single-phase mechanically pumped fluid loop applied in spacecraft thermal control system, a novel actively-pumped loop using distributed thermal control strategy was proposed. The flow control system for each branch consists primarily of a thermal control valve integrated with a paraffin-based actuator residing in the front part of each corresponding cold plate, where both coolant’s flow rate and the cold plate’s heat removal capability are well controlled sensitively according to the heat loaded upon the cold plate due to a conversion between thermal and mechanical energies. The operating economy enhances remarkably owing to no energy consumption in flow control process. Additionally, realizing the integration of the sensor, controller and actuator systems, it simplifies structure of the traditional mechanically pumped fluid loop as well. Revolving this novel scheme, mathematical model regarding design process of the highly specialized cold plate was entrenched theoretically. A validating system as a prototype was established on the basis of the design method and the scheduled objective of the controlled temperature (43 °C). Then temperature control performances of the highly self-adaptive cold plate under various operating conditions were tested experimentally. During almost all experiments, the controlled temperature remains within a range of ±2 °C around the set-point. Conclusions can be drawn that this self-driven control system is stable with sufficient fast transient responses and sufficient small steady

  10. Direct deposition of gas phase generated aerosol gold nanoparticles into biological fluids--corona formation and particle size shifts.

    Directory of Open Access Journals (Sweden)

    Christian R Svensson

    Full Text Available An ongoing discussion whether traditional toxicological methods are sufficient to evaluate the risks associated with nanoparticle inhalation has led to the emergence of Air-Liquid interface toxicology. As a step in this process, this study explores the evolution of particle characteristics as they move from the airborne state into physiological solution. Airborne gold nanoparticles (AuNP are generated using an evaporation-condensation technique. Spherical and agglomerate AuNPs are deposited into physiological solutions of increasing biological complexity. The AuNP size is characterized in air as mobility diameter and in liquid as hydrodynamic diameter. AuNP:Protein aggregation in physiological solutions is determined using dynamic light scattering, particle tracking analysis, and UV absorption spectroscopy. AuNPs deposited into homocysteine buffer form large gold-aggregates. Spherical AuNPs deposited in solutions of albumin were trapped at the Air-Liquid interface but was readily suspended in the solutions with a size close to that of the airborne particles, indicating that AuNP:Protein complex formation is promoted. Deposition into serum and lung fluid resulted in larger complexes, reflecting the formation of a more complex protein corona. UV absorption spectroscopy indicated no further aggregation of the AuNPs after deposition in solution. The corona of the deposited AuNPs shows differences compared to AuNPs generated in suspension. Deposition of AuNPs from the aerosol phase into biological fluids offers a method to study the protein corona formed, upon inhalation and deposition in the lungs in a more realistic way compared to particle liquid suspensions. This is important since the protein corona together with key particle properties (e.g. size, shape and surface reactivity to a large extent may determine the nanoparticle effects and possible translocation to other organs.

  11. Direct Deposition of Gas Phase Generated Aerosol Gold Nanoparticles into Biological Fluids - Corona Formation and Particle Size Shifts

    Science.gov (United States)

    Svensson, Christian R.; Messing, Maria E.; Lundqvist, Martin; Schollin, Alexander; Deppert, Knut; Pagels, Joakim H.; Rissler, Jenny; Cedervall, Tommy

    2013-01-01

    An ongoing discussion whether traditional toxicological methods are sufficient to evaluate the risks associated with nanoparticle inhalation has led to the emergence of Air-Liquid interface toxicology. As a step in this process, this study explores the evolution of particle characteristics as they move from the airborne state into physiological solution. Airborne gold nanoparticles (AuNP) are generated using an evaporation-condensation technique. Spherical and agglomerate AuNPs are deposited into physiological solutions of increasing biological complexity. The AuNP size is characterized in air as mobility diameter and in liquid as hydrodynamic diameter. AuNP:Protein aggregation in physiological solutions is determined using dynamic light scattering, particle tracking analysis, and UV absorption spectroscopy. AuNPs deposited into homocysteine buffer form large gold-aggregates. Spherical AuNPs deposited in solutions of albumin were trapped at the Air-Liquid interface but was readily suspended in the solutions with a size close to that of the airborne particles, indicating that AuNP:Protein complex formation is promoted. Deposition into serum and lung fluid resulted in larger complexes, reflecting the formation of a more complex protein corona. UV absorption spectroscopy indicated no further aggregation of the AuNPs after deposition in solution. The corona of the deposited AuNPs shows differences compared to AuNPs generated in suspension. Deposition of AuNPs from the aerosol phase into biological fluids offers a method to study the protein corona formed, upon inhalation and deposition in the lungs in a more realistic way compared to particle liquid suspensions. This is important since the protein corona together with key particle properties (e.g. size, shape and surface reactivity) to a large extent may determine the nanoparticle effects and possible translocation to other organs. PMID:24086363

  12. Assessment of myeloperoxidase activity at different force levels in gingival crevicular fluid during initial phase of orthodontic tooth movement

    Directory of Open Access Journals (Sweden)

    Honey Gurbaxani

    2017-01-01

    Full Text Available Background: Orthodontic movements promote remodeling of the alveolar bone, which is mediated by inflammatory reactions such as characterized by vascular changes and infiltration of leukocytes. Changes in the periodontium occur, depending on the magnitude, duration, and direction of applied force. These changes are often seen in the saliva and gingival fluids through the various substances secreted in them. Aim: The present study aimed to assess myeloperoxidase (MPO activity at different force levels in gingival crevicular fluid (GCF during the initial phase of orthodontic tooth movement by varying the effective force levels to 50, 75, 100, and 150 g. Materials and Methods: A total of thirty participants between the age groups of 18–25 years requiring upper first premolar extractions were included in the study. They were divided into three groups (I, II, and III of ten individuals each, again subdivided into two Subgroups A and B depending on the amount of force applied to the canine. Subgroup A of all the three groups used 150 g, whereas Subgroup B used 50, 75, and 100 g of force, respectively. GCF was collected at 2 h, 7 days, and 14 days of force application. Statistical Analysis: Paired t-test and ANOVA test were used to provide the descriptive statistics of mean optical density to detect the presence of MPO in GCF. Results and Conclusion: There was a highly significant increase in the MPO levels in the GCF at 14th day after force application which can be correlated to the onset of inflammatory reactions in the periodontium.

  13. Density induced crossover of electron mobilities in fluid C3 hydrocarbons; liquid phase behavior

    International Nuclear Information System (INIS)

    Gee, N.; Freeman, G.R.

    1980-01-01

    At n = 2 x 10 20 mol/cm 3 in the saturated vapors, the density normalized mobility (μn) of electrons equalled 2.4 x 10 23 mol/cmVs in cyclopropane, 1.5 x 10 23 in propane and 5.4 x 10 22 in propene. In cyclopropane and propene μn decreased due to quasilocalization at n > 4 x 10 20 mol/cm 3 . In propane quasilocalization occurred at n > 8 x 10 20 mol/cm 3 . The more extensive quasilocalization in cyclopropane caused mobilities to be lower than those in propane at the same density when the densities were greater than 1.3 x 10 21 mol/cm 3 . In propylene, μn remained below those in the other compounds at all gas densities. In the liquid phase the mobilities were affected more by the changes of temperature than by those of density. The mobilities at a given temperature decreased in the order propane > propene > cyclopropane. It is curious that the electron traps are deeper in cyclopropane than in propene. The energies of both thermal and optical excitation of solvated electrons may be expressed by equations of the form E 0 = E(0) - aT over considerable ranges of temperature T. The thermal value of a/E(0) is 1.7 x 10 -3 K -1 in many hydrocarbons, estimated from the mobilities. The equivalent ratio of the optical parameters also equals 1.7 x 10 -3 K -1 in ethers and in ammonia. (author)

  14. Determination of parathion in biological fluids by means of direct solid-phase microextraction.

    Science.gov (United States)

    Gallardo, E; Barroso, M; Margalho, C; Cruz, A; Vieira, D N; López-Rivadulla, M

    2006-11-01

    A new and simple procedure for the determination of parathion in human whole blood and urine using direct immersion (DI) solid-phase microextraction (SPME) and gas chromatography/mass spectrometry (GC/MS) is presented. This technique was developed using only 100 microL of sample, and ethion was used as internal standard (IS). A 65-microm Carbowax/divinylbenzene (CW/DVB) SPME fibre was selected for sampling, and the main parameters affecting the SPME process such as extraction temperature, adsorption and desorption time, salt addition, agitation and pH effect were optimized to enhance the sensitivity of the method. This optimization was also performed to allow the qualitative determination of parathion's main metabolite, paraoxon, in blood. The limits of detection and quantitation for parathion were 3 and 10 ng/mL for urine and 25 and 50 ng/mL for blood, respectively. For paraoxon, the limit of detection was 50 ng/mL in blood. The method showed linearity between the LOQ and 50 microg/mL for both matrices, with correlation coefficients ranging from 0.9954 to 0.9999. Precision and accuracy were in conformity with the criteria normally accepted in bioanalytical method validation. The mean absolute recoveries were 35.1% for urine and 6.7% for blood. Other parameters such as dilution of sample and stability were also validated. Its simplicity and the fact that only 100 microL of sample is required to accomplish the analysis make this method useful in forensic toxicology laboratories to determine this compound in intoxications, and it can be considered an alternative to other methods normally used for the determination of this compound in biological media.

  15. Computational fluid dynamics simulations of single-phase flow in a filter-press flow reactor having a stack of three cells

    International Nuclear Information System (INIS)

    Sandoval, Miguel A.; Fuentes, Rosalba; Walsh, Frank C.; Nava, José L.; Ponce de León, Carlos

    2016-01-01

    Highlights: • Computational fluid dynamic simulations in a filter-press stack of three cells. • The fluid velocity was different in each cell due to local turbulence. • The upper cell link pipe of the filter press cell acts as a fluid mixer. • The fluid behaviour tends towards a continuous mixing flow pattern. • Close agreement between simulations and experimental data was achieved. - Abstract: Computational fluid dynamics (CFD) simulations were carried out for single-phase flow in a pre-pilot filter press flow reactor with a stack of three cells. Velocity profiles and streamlines were obtained by solving the Reynolds-Averaged Navier-Stokes (RANS) equations with a standard k − ε turbulence model. The flow behaviour shows the appearance of jet flow at the entrance to each cell. At lengths from 12 to 15 cm along the cells channels, a plug flow pattern is developed at all mean linear flow rates studied here, 1.2 ≤ u ≤ 2.1 cm s −1 . The magnitude of the velocity profiles in each cell was different, due to the turbulence generated by the change of flow direction in the last fluid manifold. Residence time distribution (RTD) simulations indicated that the fluid behaviour tends towards a continuous mixing flow pattern, owing to flow at the output of each cell across the upper cell link pipe, which acts as a mixer. Close agreement between simulations and experimental RTD was obtained.

  16. Application of the cubic-plus-association (CPA) equation of state to model the fluid phase behaviour of binary mixtures of water and tetrahydrofuran

    DEFF Research Database (Denmark)

    Herslund, Peter Jørgensen; Thomsen, Kaj; Abildskov, Jens

    2013-01-01

    The complex fluid phase behaviour, of the binary system comprised of water and tetrahydrofuran (THF) is modelled by use of the cubic-plus-association (CPA) equation of state. A total of seven modelling approaches are analysed, differing only in their way of describing THF and its interactions...

  17. Solid-phase classical complement activation by C-reactive protein (CRP) is inhibited by fluid-phase CRP-C1q interaction

    International Nuclear Information System (INIS)

    Sjoewall, Christopher; Wetteroe, Jonas; Bengtsson, Torbjoern; Askendal, Agneta; Almroth, Gunnel; Skogh, Thomas; Tengvall, Pentti

    2007-01-01

    C-reactive protein (CRP) interacts with phosphorylcholine (PC), Fcγ receptors, complement factor C1q and cell nuclear constituents, yet its biological roles are insufficiently understood. The aim was to characterize CRP-induced complement activation by ellipsometry. PC conjugated with keyhole limpet hemocyanin (PC-KLH) was immobilized to cross-linked fibrinogen. A low-CRP serum with different amounts of added CRP was exposed to the PC-surfaces. The total serum protein deposition was quantified and deposition of IgG, C1q, C3c, C4, factor H, and CRP detected with polyclonal antibodies. The binding of serum CRP to PC-KLH dose-dependently triggered activation of the classical pathway. Unexpectedly, the activation was efficiently down-regulated at CRP levels >150 mg/L. Using radial immunodiffusion, CRP-C1q interaction was observed in serum samples with high CRP concentrations. We propose that the underlying mechanism depends on fluid-phase interaction between C1q and CRP. This might constitute another level of complement regulation, which has implications for systemic lupus erythematosus where CRP is often low despite flare-ups

  18. Measurement of the membrane dipole electric field in DMPC vesicles using vibrational shifts of p-cyanophenylalanine and molecular dynamics simulations.

    Science.gov (United States)

    Shrestha, Rebika; Cardenas, Alfredo E; Elber, Ron; Webb, Lauren J

    2015-02-19

    The magnitude of the membrane dipole field was measured using vibrational Stark effect (VSE) shifts of nitrile oscillators placed on the unnatural amino acid p-cyanophenylalanine (p-CN-Phe) added to a peptide sequence at four unique positions. These peptides, which were based on a repeating alanine-leucine motif, intercalated into small unilamellar DMPC vesicles which formed an α-helix as confirmed by circular dichroic (CD) spectroscopy. Molecular dynamics simulations of the membrane-intercalated helix containing two of the nitrile probes, one near the headgroup region of the lipid (αLAX(25)) and one buried in the interior of the bilayer (αLAX(16)), were used to examine the structure of the nitrile with respect to the membrane normal, the assumed direction of the dipole field, by quantifying both a small tilt of the helix in the bilayer and conformational rotation of the p-CN-Phe side chain at steady state. Vibrational absorption energies of the nitrile oscillator at each position showed a systematic blue shift as the nitrile was stepped toward the membrane interior; for several different concentrations of peptide, the absorption energy of the nitrile located in the middle of the bilayer was ∼3 cm(-1) greater than that of the nitrile closest to the surface of the membrane. Taken together, the measured VSE shifts and nitrile orientations within the membrane resulted in an absolute magnitude of 8-11 MV/cm for the dipole field, at the high end of the range of possible values that have been accumulated from a variety of indirect measurements. Implications for this are discussed.

  19. Cerebrospinal fluid flow waveforms: effect of altered cranial venous outflow. A phase-contrast MR flow imaging study

    International Nuclear Information System (INIS)

    Bhadelia, R.A.; Wolpert, S.M.

    1998-01-01

    Our purpose was to assess the effect of alterations in the cranial venous outflow on cerebrospinal fluid (CSF) flow waveforms using phase-contrast MRI. Thirteen healthy subjects were assessed for CSF flow and cerebral vascular flow at the C2-3 level, both before and after jugular venous compression (JVC). The flow waveforms were assessed both as an aggregate, and after dividing subjects in two groups based on percent jugular venous flow (PJVF) i. e. jugular outflow expressed as percent of cerebral arterial inflow. Group 1: 7 subjects with PJVF more than and including median (predominantly jugular outflow); Group 2: 6 subjects with PJVF less than median (predominantly extra-jugular outflow). CSF waveforms: JVC produced rounding of contours and flattening of dicrotic waves, with the effect being greater in group 1 than group 2. In group 1, systolic upslopes of the waveforms increased. No significant aggregate amplitude changes were noted; amplidutes increased in group 1 (P = 0.001), and decreased in group 2 (P = 0.03). Temporal interval to the maximum CSF systolic flow significantly increased in group 1. Vascular flow: Arterial flow significantly decreased in group 1. Jugular flow significantly decreased in both groups. The results suggest that CSF flow waveforms are sensitive to alterations in the cranial venous outflow. Changes in group 1 are most likely because of an elevation in intracranial pressure. Analysis of CSF flow waveforms appears a promising noninvasive tool for assessment of cranial compartment. (orig.)

  20. Blood flow in cerebral aneurysms: comparison of phase contrast magnetic resonance and computational fluid dynamics - preliminary experience

    Energy Technology Data Exchange (ETDEWEB)

    Karmonik, C.; Benndorf, G. [The Methodist Hospital Research Inst., Houston (United States). Radiology; Klucznik, R. [The Methodist Hospital, Houston (United States). Radiology

    2008-03-15

    Purpose: computational fluid dynamics (CFD) simulations are increasingly used to model cerebral aneurysm hemodynamics. We investigated the capability of phase contrast magnetic resonance imaging (pcMRI), guided by specialized software for optimal slice definition (NOVA, Vassol Inc.) as a non-invasive method to measure intra-aneurysmal blood flow patterns in-vivo. In a novel approach, these blood flow patterns measured with pcMRI were qualitatively compared to the ones calculated with CFD. Materials end methods: the volumetric inflow rates into three unruptured cerebral aneurysms and the temporal variations of the intra-aneurysmal blood flow patterns were recorded with pcMRI. Transient CFD simulations were performed on geometric models of these aneurysms derived from 3D digital subtraction angiograms. Calculated intra-aneurysmal blood flow patterns were compared at the times of maximum and minimum arterial inflow to the ones measured with pcMRI and the temporal variations of these patterns during the cardiac cycle were investigated. Results: in all three aneurysms, the main features of intra-aneurysmal flow patterns obtained with pcMRI consisted of areas with positive velocities components and areas with negative velocities components. The measured velocities ranged from approx. {+-}60 to {+-}100 cm/sec. Comparison with calculated CFD simulations showed good correlation with regard to the spatial distribution of these areas, while differences in calculated magnitudes of velocities were found. (orig.)

  1. Modeling and investigation of refrigeration system performance with two-phase fluid injection in a scroll compressor

    Science.gov (United States)

    Gu, Rui

    Vapor compression cycles are widely used in heating, refrigerating and air-conditioning. A slight performance improvement in the components of a vapor compression cycle, such as the compressor, can play a significant role in saving energy use. However, the complexity and cost of these improvements can block their application in the market. Modifying the conventional cycle configuration can offer a less complex and less costly alternative approach. Economizing is a common modification for improving the performance of the refrigeration cycle, resulting in decreasing the work required to compress the gas per unit mass. Traditionally, economizing requires multi-stage compressors, the cost of which has restrained the scope for practical implementation. Compressors with injection ports, which can be used to inject economized refrigerant during the compression process, introduce new possibilities for economization with less cost. This work focuses on computationally investigating a refrigeration system performance with two-phase fluid injection, developing a better understanding of the impact of injected refrigerant quality on refrigeration system performance as well as evaluating the potential COP improvement that injection provides based on refrigeration system performance provided by Copeland.

  2. An Overview of In-Space Propulsion and Cryogenics Fluids Management Efforts for 2014 SBIR Phases I and II

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2016-01-01

    NASA's Small Business Innovation Research (SBIR) program focuses on technological innovation by investing in the development of innovative concepts and technologies to help NASA's mission directorates address critical research and development needs for Agency programs. This report highlights 11 of the innovative SBIR 2014 Phase I and II projects from 2010 to 2012 that focus on one of NASA Glenn Research Center's six core competencies-In-Space Propulsion and Cryogenic Fluids Management. The technologies cover a wide spectrum of applications such as divergent field annular ion engines, miniature nontoxic nitrous oxide-propane propulsion, noncatalytic ignition systems for high-performance advanced monopropellant thrusters, nontoxic storable liquid propulsion, and superconducting electric boost pumps for nuclear thermal propulsion. Each article describes an innovation and technical objective and highlights NASA commercial and industrial applications. This report provides an opportunity for NASA engineers, researchers, and program managers to learn how NASA SBIR technologies could help their programs and projects, and lead to collaborations and partnerships between the small SBIR companies and NASA that would benefit both.

  3. Fabrication of fluorographene nanosheets with high yield and good quality based on supercritical fluid-phase exfoliation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Qi; Ji, Yan; Zhang, Danying; Shi, Jia [Nanjing University of Science and Technology, Key Laboratory of Soft Chemistry and Functional Materials, College of Chemical Engineering (China); Xiao, Yinghong, E-mail: yhxiao@njnu.edu.cn [Nanjing Normal University, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science (China); Che, Jianfei, E-mail: xiaoche@mail.njust.edu.cn [Nanjing University of Science and Technology, Key Laboratory of Soft Chemistry and Functional Materials, College of Chemical Engineering (China)

    2016-07-15

    This article presents a novel and simple method of supercritical fluid-phase exfoliation to fabricate fluorographene (FG) nanosheets with high yield and good quality. After soaking with supercritical CO{sub 2} and glycol at 10 MPa and 50 °C for 24 h, fluoride graphite powder was exfoliated by the intercalated CO{sub 2} and glycol molecules during an abrupt depressurization step. Here, supercritical CO{sub 2} acted as a penetrant and glycol acted as a “molecular wedge” to exfoliate fluoride graphite very well. The properties of FG nanosheets were detected by TEM, AFM, UV spectra, FTIR, XPS, Raman spectra, and XRD, which show the possibility of producing thickness-controlled FG nanosheets by varying numbers of supercritical CO{sub 2} process and the high yield of pure FG nanosheets of 32 wt%, four times higher than that of the sample treated only by the traditional method of sonication. Its simplicity, high productivity, low cost, and short processing time make this technique suitable for large-scale manufacturing of FG nanosheets.

  4. Blood flow in cerebral aneurysms: comparison of phase contrast magnetic resonance and computational fluid dynamics - preliminary experience

    International Nuclear Information System (INIS)

    Karmonik, C.; Benndorf, G.; Klucznik, R.

    2008-01-01

    Purpose: computational fluid dynamics (CFD) simulations are increasingly used to model cerebral aneurysm hemodynamics. We investigated the capability of phase contrast magnetic resonance imaging (pcMRI), guided by specialized software for optimal slice definition (NOVA, Vassol Inc.) as a non-invasive method to measure intra-aneurysmal blood flow patterns in-vivo. In a novel approach, these blood flow patterns measured with pcMRI were qualitatively compared to the ones calculated with CFD. Materials end methods: the volumetric inflow rates into three unruptured cerebral aneurysms and the temporal variations of the intra-aneurysmal blood flow patterns were recorded with pcMRI. Transient CFD simulations were performed on geometric models of these aneurysms derived from 3D digital subtraction angiograms. Calculated intra-aneurysmal blood flow patterns were compared at the times of maximum and minimum arterial inflow to the ones measured with pcMRI and the temporal variations of these patterns during the cardiac cycle were investigated. Results: in all three aneurysms, the main features of intra-aneurysmal flow patterns obtained with pcMRI consisted of areas with positive velocities components and areas with negative velocities components. The measured velocities ranged from approx. ±60 to ±100 cm/sec. Comparison with calculated CFD simulations showed good correlation with regard to the spatial distribution of these areas, while differences in calculated magnitudes of velocities were found. (orig.)

  5. Investigating the Relationship between Cerebrospinal Fluid and Magnetic Induction Phase Shift in Rabbit Intracerebral hematoma expansion Monitoring by MRI.

    Science.gov (United States)

    Chen, Mingsheng; Yan, Qingguang; Sun, Jian; Jin, Gui; Qin, Mingxin

    2017-09-11

    In a prior study of intracerebral hemorrhage monitoring using magnetic induction phase shift (MIPS), we found that MIPS signal changes occurred prior to those seen with intracranial pressure. However, the characteristic MIPS alert is not yet fully explained. Combining the brain physiology and MIPS theory, we propose that cerebrospinal fluid (CSF) may be the primary factor that leads to hematoma expansion being alerted by MIPS earlier than with intracranial pressure monitoring. This paper investigates the relationship between CSF and MIPS in monitoring of rabbit intracerebral hemorrhage models, which is based on the MIPS measurements data, the quantified data on CSF from medical images and the amount of injected blood in the rabbit intracerebral hemorrhage model. In the investigated results, a R value of 0.792 with a significance of 0.019 is observed between the MIPS and CSF, which is closer than MIPS and injected blood. Before the reversal point of MIPS, CSF is the leading factor in MIPS signal changing in an early hematoma expansion stage. Under CSF compensation, CSF reduction compensates for hematoma expansion in the brain to keep intracranial pressure stable. MIPS decrease results from the reducing CSF volume. This enables MIPS to detect hematoma expansion earlier than intracranial pressure.

  6. Fluorescently labeled methyl-beta-cyclodextrin enters intestinal epithelial Caco-2 cells by fluid-phase endocytosis.

    Directory of Open Access Journals (Sweden)

    Ferenc Fenyvesi

    Full Text Available Cyclodextrins are widely used excipients for increasing the bioavailability of poorly water-soluble drugs. Their effect on drug absorption in the gastrointestinal tract is explained by their solubility- and permeability-enhancement. The aims of this study were to investigate penetration properties of fluorescently labeled randomly methylated-beta-cyclodextrin (FITC-RAMEB on Caco-2 cell layer and examine the cellular entry of cyclodextrins on intestinal cells. The permeability of FITC-RAMEB through Caco-2 monolayers was very limited. Using this compound in 0.05 mM concentration the permeability coefficient was 3.35±1.29×10(-8 cm/s and its permeability did not change in the presence of 5 mM randomly methylated-beta-cyclodextrin. Despite of the low permeability, cellular accumulation of FITC-RAMEB in cytoplasmic vesicles was significant and showed strong time and concentration dependence, similar to the characteristics of the macropinocytosis marker Lucifer Yellow. The internalization process was fully inhibited at 0°C and it was drastically reduced at 37°C applying rottlerin, an inhibitor of macropinocytosis. Notably, FITC-RAMEB colocalized with the early endosome organizer Rab5a. These results have revealed that FITC-RAMEB is able to enter intestinal epithelial cells by fluid-phase endocytosis from the apical side. This mechanism can be an additional process which helps to overcome the intestinal barrier and contributes to the bioavailability enhancement of cyclodextrins.

  7. Simultaneous achiral-chiral analysis of pharmaceutical compounds using two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography.

    Science.gov (United States)

    Venkatramani, C J; Al-Sayah, Mohammad; Li, Guannan; Goel, Meenakshi; Girotti, James; Zang, Lisa; Wigman, Larry; Yehl, Peter; Chetwyn, Nik

    2016-02-01

    A new interface was designed to enable the coupling of reversed phase liquid chromatography (RPLC) and supercritical fluid chromatography (SFC). This online two-dimensional chromatographic system utilizing RPLC in the first dimension and SFC in the second was developed to achieve simultaneous achiral and chiral analysis of pharmaceutical compounds. The interface consists of an eight-port, dual-position switching valve with small volume C-18 trapping columns. The peaks of interest eluting from the first RPLC dimension column were effectively focused as sharp concentration pulses on small volume C-18 trapping column/s and then injected onto the second dimension SFC column. The first dimension RPLC separation provides the achiral purity result, and the second dimension SFC separation provides the chiral purity result (enantiomeric excess). The results are quantitative enabling simultaneous achiral, chiral analysis of compounds. The interface design and proof of concept demonstration are presented. Additionally, comparative studies to conventional SFC and case studies of the applications of 2D LC-SFC in pharmaceutical analysis is presented. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Vapor-liquid phase behavior of a size-asymmetric model of ionic fluids confined in a disordered matrix: The collective-variables-based approach

    Science.gov (United States)

    Patsahan, O. V.; Patsahan, T. M.; Holovko, M. F.

    2018-02-01

    We develop a theory based on the method of collective variables to study the vapor-liquid equilibrium of asymmetric ionic fluids confined in a disordered porous matrix. The approach allows us to formulate the perturbation theory using an extension of the scaled particle theory for a description of a reference system presented as a two-component hard-sphere fluid confined in a hard-sphere matrix. Treating an ionic fluid as a size- and charge-asymmetric primitive model (PM) we derive an explicit expression for the relevant chemical potential of a confined ionic system which takes into account the third-order correlations between ions. Using this expression, the phase diagrams for a size-asymmetric PM are calculated for different matrix porosities as well as for different sizes of matrix and fluid particles. It is observed that general trends of the coexistence curves with the matrix porosity are similar to those of simple fluids under disordered confinement, i.e., the coexistence region gets narrower with a decrease of porosity and, simultaneously, the reduced critical temperature Tc* and the critical density ρi,c * become lower. At the same time, our results suggest that an increase in size asymmetry of oppositely charged ions considerably affects the vapor-liquid diagrams leading to a faster decrease of Tc* and ρi,c * and even to a disappearance of the phase transition, especially for the case of small matrix particles.

  9. Fluid-flow pressure measurements and thermo-fluid characterization of a single loop two-phase passive heat transfer device

    Science.gov (United States)

    Ilinca, A.; Mangini, D.; Mameli, M.; Fioriti, D.; Filippeschi, S.; Araneo, L.; Roth, N.; Marengo, M.

    2017-11-01

    A Novel Single Loop Pulsating Heat Pipe (SLPHP), with an inner diameter of 2 mm, filled up with two working fluids (Ethanol and FC-72, Filling Ratio of 60%), is tested in Bottom Heated mode varying the heating power and the orientation. The static confinement diameter for Ethanol and FC-72, respectively 3.4 mm and 1.7mm, is above and slightly under the inner diameter of the tube. This is important for a better understanding of the working principle of the device very close to the limit between the Loop Thermosyphon and Pulsating Heat Pipe working modes. With respect to previous SLPHP experiments found in the literature, such device is designed with two transparent inserts mounted between the evaporator and the condenser allowing direct fluid flow visualization. Two highly accurate pressure transducers permit local pressure measurements just at the edges of one of the transparent inserts. Additionally, three heating elements are controlled independently, so as to vary the heating distribution at the evaporator. It is found that peculiar heating distributions promote the slug/plug flow motion in a preferential direction, increasing the device overall performance. Pressure measurements point out that the pressure drop between the evaporator and the condenser are related to the flow pattern. Furthermore, at high heat inputs, the flow regimes recorded for the two fluids are very similar, stressing that, when the dynamic effects start to play a major role in the system, the device classification between Loop Thermosyphon and Pulsating Heat Pipe is not that sharp anymore.

  10. Effect of Porous Media and Fluid Properties on Dense Non-Aqueous Phase Liquid Migration and Dilution Mass Flux

    National Research Council Canada - National Science Library

    Totten, Christian T

    2005-01-01

    .... Media grain size and NAPL wettability were varied for relative comparisons. Fluid properties including density differential and interfacial tension between NAPL and water were varied for relative comparisons...

  11. Molecular Simulations As a Tool for Predicting Phase Equilibria and Transport Properties of Fluids Les simulations moléculaires comme outils pour prédire les équilibres de phases et les propriétés de transport des fluides

    Directory of Open Access Journals (Sweden)

    Fuchs A.

    2006-12-01

    Full Text Available koWe briefly review the molecular simulation methods which can be used to predict thermophysical properties of fluids and fluid mixtures. It is shown in this paper, on the one hand, how the Gibbs Ensemble Monte Carlo Method allows phase behavior predictions for real fluids under conditions for which experimental data are difficult or impossible to obtain. On the other hand, the molecular dynamics methods used for predicting transport properties of molecular fluids are described. Finally we discuss possible future applications of these methods. Dans cet article, nous passons brièvement en revue les méthodes de simulation moléculaire applicables à la prédiction des propriétés thermophysiques des fluides et des mélanges. Nous montrons, d'une part, comment la méthode de Monte-Carlo dans l'ensemble de Gibbs permet de prédire le comportement de phase de fluides réels dans des conditions telles que l'acquisition de données expérimentales serait difficile, voire impossible. D'autre part, nous décrivons les méthodes de dynamique moléculaire utilisées pour prédire les propriétés de transport de fluides moléculaires. Enfin, nous discutons le potentiel de ces méthodes pour les applications futures.

  12. Multiparticle imaging technique for two-phase fluid flows using pulsed laser speckle velocimetry. Final report, September 1988--November 1992

    Energy Technology Data Exchange (ETDEWEB)

    Hassan, T.A.

    1992-12-01

    The practical use of Pulsed Laser Velocimetry (PLV) requires the use of fast, reliable computer-based methods for tracking numerous particles suspended in a fluid flow. Two methods for performing tracking are presented. One method tracks a particle through multiple sequential images (minimum of four required) by prediction and verification of particle displacement and direction. The other method, requiring only two sequential images uses a dynamic, binary, spatial, cross-correlation technique. The algorithms are tested on computer-generated synthetic data and experimental data which was obtained with traditional PLV methods. This allowed error analysis and testing of the algorithms on real engineering flows. A novel method is proposed which eliminates tedious, undersirable, manual, operator assistance in removing erroneous vectors. This method uses an iterative process involving an interpolated field produced from the most reliable vectors. Methods are developed to allow fast analysis and presentation of sets of PLV image data. Experimental investigation of a two-phase, horizontal, stratified, flow regime was performed to determine the interface drag force, and correspondingly, the drag coefficient. A horizontal, stratified flow test facility using water and air was constructed to allow interface shear measurements with PLV techniques. The experimentally obtained local drag measurements were compared with theoretical results given by conventional interfacial drag theory. Close agreement was shown when local conditions near the interface were similar to space-averaged conditions. However, theory based on macroscopic, space-averaged flow behavior was shown to give incorrect results if the local gas velocity near the interface as unstable, transient, and dissimilar from the average gas velocity through the test facility.

  13. The differences in matrix effect between supercritical fluid chromatography and reversed phase liquid chromatography coupled to ESI/MS.

    Science.gov (United States)

    Svan, Alfred; Hedeland, Mikael; Arvidsson, Torbjörn; Pettersson, Curt E

    2018-02-13

    For many sample matrices, matrix effects are a troublesome phenomenon using the electrospray ionization source. The increasing use of supercritical fluid chromatography with CO 2 in combination with the electrospray ionization source for MS detection is therefore raising questions: is the matrix effect behaving differently using SFC in comparison with reversed phase LC? This was investigated using urine, plasma, influent- and effluent-wastewater as sample matrices. The matrix effect was evaluated using the post-extraction addition method and through post-column infusions. Matrix effect profiles generated from the post-column infusions in combination with time of flight-MS detection provided the most valuable information for the study. The combination of both qualitative and semi-quantitative information with the ability to use HRMS-data for identifying interfering compounds from the same experiment was very useful, and has to the authors' knowledge not been used this way before. The results showed that both LC and SFC are affected by matrix effects, however differently depending on sample matrix. Generally, both suppressions and enhancements were seen, with a higher amount of enhancements for LC, where 65% of all compounds and all sample matrices were enhanced, compared to only 7% for SFC. Several interferences were tentatively identified, with phospholipids, creatinine, and metal ion clusters as examples of important interferences, with different impact depending on chromatographic technique. SFC needs a different strategy for limiting matrix interferences, owing to its almost reverse retention order compared to RPLC. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. An interfacial shear term evaluation study for adiabatic dispersed air–water two-phase flow with the two-fluid model using CFD

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, S.L., E-mail: sharma55@purdue.edu [School of Nuclear Engineering, Purdue University, West Lafayette, IN (United States); Hibiki, T.; Ishii, M. [School of Nuclear Engineering, Purdue University, West Lafayette, IN (United States); Schlegel, J.P. [Department of Mining and Nuclear Engineering, Missouri University of Science and Technology, Rolla, MO (United States); Buchanan, J.R.; Hogan, K.J. [Bettis Laboratory, Naval Nuclear Laboratory, West Mifflin, PA (United States); Guilbert, P.W. [ANSYS UK Ltd, Oxfordshire (United Kingdom)

    2017-02-15

    Highlights: • Closure form of the interfacial shear term in three-dimensional form is investigated. • Assessment against adiabatic upward bubbly air–water flow data using CFD. • Effect of addition of the interfacial shear term on the phase distribution. - Abstract: In commercially available Computational Fluid Dynamics (CFD) codes such as ANSYS CFX and Fluent, the interfacial shear term is missing in the field momentum equations. The derivation of the two-fluid model (Ishii and Hibiki, 2011) indicates the presence of this term as a momentum source in the right hand side of the field momentum equation. The inclusion of this term is considered important for proper modeling of the interfacial momentum coupling between phases. For separated flows, such as annular flow, the importance of the shear term is understood in the one-dimensional (1-D) form as the major mechanism by which the wall shear is transferred to the gas phase (Ishii and Mishima, 1984). For gas dispersed two-phase flow CFD simulations, it is important to assess the significance of this term in the prediction of phase distributions. In the first part of this work, the closure of this term in three-dimensional (3-D) form in a CFD code is investigated. For dispersed gas–liquid flow, such as bubbly or churn-turbulent flow, bubbles are dispersed in the shear layer of the continuous phase. The continuous phase shear stress is mainly due to the presence of the wall and the modeling of turbulence through the Boussinesq hypothesis. In a 3-D simulation, the continuous phase shear stress can be calculated from the continuous fluid velocity gradient, so that the interfacial shear term can be closed using the local values of the volume fraction and the total stress of liquid phase. This form also assures that the term acts as an action-reaction force for multiple phases. In the second part of this work, the effect of this term on the volume fraction distribution is investigated. For testing the model two-phase

  15. The Computational Fluid Dynamics Rupture Challenge 2013--Phase II: Variability of Hemodynamic Simulations in Two Intracranial Aneurysms.

    Science.gov (United States)

    Berg, Philipp; Roloff, Christoph; Beuing, Oliver; Voss, Samuel; Sugiyama, Shin-Ichiro; Aristokleous, Nicolas; Anayiotos, Andreas S; Ashton, Neil; Revell, Alistair; Bressloff, Neil W; Brown, Alistair G; Chung, Bong Jae; Cebral, Juan R; Copelli, Gabriele; Fu, Wenyu; Qiao, Aike; Geers, Arjan J; Hodis, Simona; Dragomir-Daescu, Dan; Nordahl, Emily; Bora Suzen, Yildirim; Owais Khan, Muhammad; Valen-Sendstad, Kristian; Kono, Kenichi; Menon, Prahlad G; Albal, Priti G; Mierka, Otto; Münster, Raphael; Morales, Hernán G; Bonnefous, Odile; Osman, Jan; Goubergrits, Leonid; Pallares, Jordi; Cito, Salvatore; Passalacqua, Alberto; Piskin, Senol; Pekkan, Kerem; Ramalho, Susana; Marques, Nelson; Sanchi, Stéphane; Schumacher, Kristopher R; Sturgeon, Jess; Švihlová, Helena; Hron, Jaroslav; Usera, Gabriel; Mendina, Mariana; Xiang, Jianping; Meng, Hui; Steinman, David A; Janiga, Gábor

    2015-12-01

    With the increased availability of computational resources, the past decade has seen a rise in the use of computational fluid dynamics (CFD) for medical applications. There has been an increase in the application of CFD to attempt to predict the rupture of intracranial aneurysms, however, while many hemodynamic parameters can be obtained from these computations, to date, no consistent methodology for the prediction of the rupture has been identified. One particular challenge to CFD is that many factors contribute to its accuracy; the mesh resolution and spatial/temporal discretization can alone contribute to a variation in accuracy. This failure to identify the importance of these factors and identify a methodology for the prediction of ruptures has limited the acceptance of CFD among physicians for rupture prediction. The International CFD Rupture Challenge 2013 seeks to comment on the sensitivity of these various CFD assumptions to predict the rupture by undertaking a comparison of the rupture and blood-flow predictions from a wide range of independent participants utilizing a range of CFD approaches. Twenty-six groups from 15 countries took part in the challenge. Participants were provided with surface models of two intracranial aneurysms and asked to carry out the corresponding hemodynamics simulations, free to choose their own mesh, solver, and temporal discretization. They were requested to submit velocity and pressure predictions along the centerline and on specified planes. The first phase of the challenge, described in a separate paper, was aimed at predicting which of the two aneurysms had previously ruptured and where the rupture site was located. The second phase, described in this paper, aims to assess the variability of the solutions and the sensitivity to the modeling assumptions. Participants were free to choose boundary conditions in the first phase, whereas they were prescribed in the second phase but all other CFD modeling parameters were not

  16. Fluid phases contemporary with sandstone diagenesis tectonic movements and the activity of the natural nuclear reactors in the Oklo deposit, Republic of Gabon

    International Nuclear Information System (INIS)

    Poty, B.

    1979-12-01

    A research contract was agreed between the IAEA and the Centre de Recherches Petrographiques et Geochimiques of Nancy (France) to analyze some aspects of the fluid phases present during diagenesis of the Precambrian Francevillean sandstones of Gabon, which include the Oklo uranium deposit in which because of the geometry of the ore body, the high ore grade, etc., a natural uranium reactor was formed. The investigation was orientated to define some special characteristics of the fluid inclusions and two main methods were applied for this purpose: The Raman spectroscopy (MOLE microsonde) and microthermometric analysis. The main conclusions of the research are the following: 1. The Francevillean sandstones were buried up to a depth of 4-5 km where the corresponding geothermal temperature was of around 240 0 C but during the Oklo nuclear reaction, the fluid temperatures were higher than 450 0 C and in at least one case (Zone II) up to 600 0 C. 2. The tectonic fracturing has favoured the fluid circulation, which was possibly the responsible of the mineral re-concentration after the Oklo nuclear reaction. 3. The diagenetic fluids were essentially aqueous solutions and no sulphur components were identified. 4. The hydrogen presence in a quartz veinlet is surprising and possibly due to water decomposition by strong irradiation

  17. Reconciling structural and thermodynamic predictions using all-atom and coarse-grain force fields: the case of charged oligo-arginine translocation into DMPC bilayers.

    Science.gov (United States)

    Hu, Yuan; Sinha, Sudipta Kumar; Patel, Sandeep

    2014-10-16

    Using the translocation of short, charged cationic oligo-arginine peptides (mono-, di-, and triarginine) from bulk aqueous solution into model DMPC bilayers, we explore the question of the similarity of thermodynamic and structural predictions obtained from molecular dynamics simulations using all-atom and Martini coarse-grain force fields. Specifically, we estimate potentials of mean force associated with translocation using standard all-atom (CHARMM36 lipid) and polarizable and nonpolarizable Martini force fields, as well as a series of modified Martini-based parameter sets. We find that we are able to reproduce qualitative features of potentials of mean force of single amino acid side chain analogues into model bilayers. In particular, modifications of peptide-water and peptide-membrane interactions allow prediction of free energy minima at the bilayer-water interface as obtained with all-atom force fields. In the case of oligo-arginine peptides, the modified parameter sets predict interfacial free energy minima as well as free energy barriers in almost quantitative agreement with all-atom force field based simulations. Interfacial free energy minima predicted by a modified coarse-grained parameter set are -2.51, -4.28, and -5.42 for mono-, di-, and triarginine; corresponding values from all-atom simulations are -0.83, -3.33, and -3.29, respectively, all in units of kcal/mol. We found that a stronger interaction between oligo-arginine and the membrane components and a weaker interaction between oligo-arginine and water are crucial for producing such minima in PMFs using the polarizable CG model. The difference between bulk aqueous and bilayer center states predicted by the modified coarse-grain force field are 11.71, 14.14, and 16.53 kcal/mol, and those by the all-atom model are 6.94, 8.64, and 12.80 kcal/mol; those are of almost the same order of magnitude. Our simulations also demonstrate a remarkable similarity in the structural aspects of the ensemble of

  18. Kinetics and mechanism of transitions involving the lamellar, cubic, inverted hexagonal, and fluid isotropic phases of hydrated monoacylglycerides monitored by time-resolved X-ray diffraction

    International Nuclear Information System (INIS)

    Caffrey, M.

    1987-01-01

    A study of the dynamics and mechanism of the various thermotropic phase transitions undergone by the hydrated monoacylglycerides monoolein and monoelaidin, in the temperature range of 20-120 0 C and from 0 to 5 M NaCl, has been undertaken. Measurements were made by using time-resolved X-ray diffraction at the Cornell High-Energy Synchrotron Source. The lamellar chain order/disorder, lamellar/cubic (body centered, space group No.8), cubic (body centered, No.8)/cubic (primitive No.4), cubic (body centered, No.12)/cubic (primitive, No.4), cubic (primitive, No.4)/fluid isotropic, cubic (body centered, No.12)/inverted hexagonal, cubic (primitive, No.4)/inverted hexagonal, and hexagonal/fluid isotropic transitions were examined under active heating and passive cooling by using a jump in temperature to effect phase transformation. All of the transitions with the exception of the cubic (body centered, No.8)/cubic (primitive, No.4) and the cubic (body centered, No.12)/cubic (primitive, No.4) cooling transitions were found (1) to be repeatable, (2) to be reversible, and (3) to have an upper bound on the transit time (time required to complete the transition) of ≤ 3s. In addition to the time-resolved measurements, data were obtained on the stability of the various phases in the temperature range of 20-120 0 C and from 0 to 5 M NaCl. In the case of fully hydrated monoolein, high salt strongly favors the hexagonal over the cubic (body centered, No.8) phase and slightly elevates the hexagonal/fluid isotropic transition temperature. With fully hydrated monoelaidin, the hexagonal phase which is not observed in the absence of salt becomes the dominant phase at high salt concentration

  19. A Designer Fluid For Aluminum Phase Change Devices. Performance Enhancement in Copper Heat Pipes Performance Enhancement in Copper Heat Pipes. Volume 3

    Science.gov (United States)

    2016-11-17

    comprised of a hollow metal shell filled with a small amount of working fluid creating a device that is extremely lightweight. Phase change devices...critical angle, the droplet unpins and the diameter decreases with a constant contact angle as the liquid core shrinks toward the center. Deegan et al...measurement system The thermocouple switch was encased in a box with fiberglass insulation to create an isothermal environment for the switch leads

  20. Comparison of hemodynamics of intracranial aneurysms between MR fluid dynamics using 3D cine phase-contrast MRI and MR-based computational fluid dynamics

    International Nuclear Information System (INIS)

    Isoda, Haruo; Sakahara, Harumi; Ohkura, Yasuhide; Kosugi, Takashi; Hirano, Masaya; Alley, Marcus T.; Bammer, Roland; Pelc, Norbert J.; Namba, Hiroki

    2010-01-01

    Hemodynamics is thought to play a very important role in the initiation, growth, and rupture of intracranial aneurysms. The purpose of our study was to compare hemodynamics of intracranial aneurysms of MR fluid dynamics (MRFD) using 3D cine PC MR imaging (4D-Flow) at 1.5 T and MR-based computational fluid dynamics (CFD). 4D-Flow was performed for five intracranial aneurysms by a 1.5 T MR scanner. 3D TOF MR angiography was performed for geometric information. The blood flow in the aneurysms was modeled using CFD simulation based on the finite element method. We used MR angiographic data as the vascular models and MR flow information as boundary conditions in CFD. 3D velocity vector fields, 3D streamlines, shearing velocity maps, wall shear stress (WSS) distribution maps and oscillatory shear index (OSI) distribution maps were obtained by MRFD and CFD and were compared. There was a moderate to high degree of correlation in 3D velocity vector fields and a low to moderate degree of correlation in WSS of aneurysms between MRFD and CFD using regression analysis. The patterns of 3D streamlines were similar between MRFD and CFD. The small and rotating shearing velocities and higher OSI were observed at the top of the spiral flow in the aneurysms. The pattern and location of shearing velocity in MRFD and CFD were similar. The location of high oscillatory shear index obtained by MRFD was near to that obtained by CFD. MRFD and CFD of intracranial aneurysms correlated fairly well. (orig.)

  1. Incorporation of poly-saccharidic derivatives in model biological systems: monolayers, lamellar phases and vesicles

    International Nuclear Information System (INIS)

    Deme, Bruno

    1995-01-01

    Our aim is to introduce a soluble polymer in a lyotropic lamellar phase, and to modify the force balance in the case of a collapsed system where no repulsive contribution overcomes the van der Waals attraction, except at very short distances where hydration forces dominate (i.e. a collapsed stack of membranes). Mixed layers of a synthetic lecithin (DMPC) and a hydrophobically modified polysaccharide (cholesteryl-pullulan, CHP) have been investigated at the air-water interface by surface tension experiments and by specular reflection of neutrons. The DMPC/CHP/water ternary phase diagram has been determined by small angle X-ray scattering (SAXS) and small angle neutron scattering (SANS). CHP derivatives are associative polymers bearing lateral cholesterol groups that interact with a polar phases such as phospholipid monolayers and biological membranes. These derivatives are surface active and self-aggregate in solution leading to the formation of soluble micellar type aggregates. The interaction of CHP derivatives with lipidic structures involves the anchoring of the cholesterol groups that yields to the tethering of the poly-saccharidic backbones at lipid/water interfaces. These poly-saccharidic backbones are flexible chains in good solvent in water. Using these derivatives and a new preparation procedure, we show that it is possible to avoid the depletion of the polysaccharide due to its steric exclusion by the collapsed DMPC lamellar phase. We are able to prepare samples at thermodynamic equilibrium with the polysaccharide solubilized in the lamellar phase, a situation opposed to the well known behavior of mixed polysaccharide/lecithin Systems commonly used in osmotic stress experiments. Here, the osmotic pressure of the chains confined in the lamellar lattice acts as a new long range repulsive contribution in the DMPC lyotropic L_α phase and results in the swelling of the lamellar phase at large membrane separations (570 A). Such bilayer separations allow out of

  2. Etude d'un modele de Boltzmann sur reseau pour la simulation assistee par ordinateur des fluides a plusieurs phases immiscibles

    Science.gov (United States)

    Leclaire, Sebastien

    The computer assisted simulation of the dynamics of fluid flow has been a highly rewarding topic of research for several decades now, in terms of the number of scientific problems that have been solved as a result, both in the academic world and in industry. In the fluid dynamics field, simulating multiphase immiscible fluid flow remains a challenge, because of the complexity of the interactions at the flow phase interfaces. Various numerical methods are available to study these phenomena, and, the lattice Boltzmann method has been shown in recent years to be well adapted to solving this type of complex flow. In this thesis, a lattice Boltzmann model for the simulation of two-phase immiscible flows is studied. The main objective of the thesis is to develop this promising method further, with a view to enhancing its validity. To achieve this objective, the research is divided into five distinct themes. The first two focus on correcting some of the deficiencies of the original model. The third generalizes the model to support the simulation of N-phase immiscible fluid flows. The fourth is aimed at modifying the model itself, to enable the simulation of immiscible fluid flows in which the density of the phases varies. With the lattice Boltzmann class of models studied here, this density variation has been inadequately modeled, and, after 20 years, the issue still has not been resolved. The fifth, which complements this thesis, is connected with the lattice Boltzmann method, in that it generalizes the theory of 2D and 3D isotropic gradients for a high order of spatial precision. These themes have each been the subject of a scientific article, as listed in the appendix to this thesis, and together they constitute a synthesis that explains the links between the articles, as well as their scientific contributions, and satisfy the main objective of this research. Globally, a number of qualitative and quantitative test cases based on the theory of multiphase fluid flows

  3. Turbulent mixing between subchannels in a gas-liquid two-phase flow. For the equilibrium flow without net fluid transfer between subchannels

    International Nuclear Information System (INIS)

    Kawahara, Akimaro; Sadatomi, Michio; Sato, Yoshifusa; Saito, Hidetoshi.

    1995-01-01

    To provide data necessary for modeling turbulent mixing between subchannels in a nuclear fuel rod bundle, three experiments were made in series for equilibrium two-phase flows, in which net mass exchange does not occur between subchannels for each phase. The first one was the measurement of turbulent mixing rates of both gas and liquid phases by a tracer technique, using air and water as the working fluids. Three kinds of vertical test channels consisting of two subchannels were used. The data have shown that the turbulent mixing rate of each phase in a two-phase flow is strongly dependent on flow regime. So, to see the relation between turbulent mixing and two-phase flow configuration in the subchannels, the second experiment, flow visualization, was made. It was observed in slug and churn flows that a lateral inter-subchannel liquid flow of a large scale is caused by the successive axial transit of large gas bubbles in each subchannel, and the turbulent mixing for the liquid phase is dominated by this lateral flow. To investigate a driving force of such large scale lateral flow, the third experiment, the measurement of an instantaneous pressure differential between the subchannels, was made. The result showed that there is a close relationship between the liquid phase mixing rate and the magnitude of the pressure differential fluctuation. (author)

  4. Basic study on an energy conversion system using boiling two-phase flows of temperature-sensitive magnetic fluid. Theoretical analysis based on thermal nonequilibrium model and flow visualization using ultrasonic echo

    International Nuclear Information System (INIS)

    Ishimoto, Jun; Kamiyama, Shinichi; Okubo, Masaaki.

    1995-01-01

    Effects of magnetic field on the characteristics of boiling two-phase pipe flow of temperature-sensitive magnetic fluid are clarified in detail both theoretically and experimentally. Firstly, governing equations of two-phase magnetic fluid flow based on the thermal nonequilibrium two-fluid model are presented and numerically solved considering evaporation and condensation between gas- and liquid-phases. Next, behaviour of vapor bubbles is visualized with ultrasonic echo in the region of nonuniform magnetic field. This is recorded and processed with an image processor. As a result, the distributions of void fraction in the two-phase flow are obtained. Furthermore, detailed characteristics of the two-phase magnetic fluid flow are investigated using a small test loop of the new energy conversion system. From the numerical and experimental results, it is known that the precise control of the boiling two-phase flow and bubble generation is possible by using the nonuniform magnetic field effectively. These fundamental studies on the characteristics of two-phase magnetic fluid flow will contribute to the development of the new energy conversion system using a gas-liquid boiling two-phase flow of magnetic fluid. (author)

  5. An energy stable algorithm for a quasi-incompressible hydrodynamic phase-field model of viscous fluid mixtures with variable densities and viscosities

    Science.gov (United States)

    Gong, Yuezheng; Zhao, Jia; Wang, Qi

    2017-10-01

    A quasi-incompressible hydrodynamic phase field model for flows of fluid mixtures of two incompressible viscous fluids of distinct densities and viscosities is derived by using the generalized Onsager principle, which warrants the variational structure, the mass conservation and energy dissipation law. We recast the model in an equivalent form and discretize the equivalent system in space firstly to arrive at a time-dependent ordinary differential and algebraic equation (DAE) system, which preserves the mass conservation and energy dissipation law at the semi-discrete level. Then, we develop a temporal discretization scheme for the DAE system, where the mass conservation and the energy dissipation law are once again preserved at the fully discretized level. We prove that the fully discretized algorithm is unconditionally energy stable. Several numerical examples, including drop dynamics of viscous fluid drops immersed in another viscous fluid matrix and mixing dynamics of binary polymeric solutions, are presented to show the convergence property as well as the accuracy and efficiency of the new scheme.

  6. Modelling of fluid flow phenomenon in laser+GMAW hybrid welding of aluminum alloy considering three phase coupling and arc plasma shear stress

    Science.gov (United States)

    Xu, Guoxiang; Li, Pengfei; Cao, Qingnan; Hu, Qingxian; Gu, Xiaoyan; Du, Baoshuai

    2018-03-01

    The present study aims to develop a unified three dimensional numerical model for fiber laser+GMAW hybrid welding, which is used to study the fluid flow phenomena in hybrid welding of aluminum alloy and the influence of laser power on weld pool dynamic behavior. This model takes into account the coupling of gas, liquid and metal phases. Laser heat input is described using a cone heat source model with changing peak power density, its height being determined based on the keyhole size. Arc heat input is modeled as a double ellipsoid heat source. The arc plasma flow and droplet transfer are simulated through the two simplified models. The temperature and velocity fields for different laser powers are calculated. The computed results are in general agreement with the experimental data. Both the peak and average values of fluid flow velocity during hybrid welding are much higher than those of GMAW. At a low level of laser power, both the arc force and droplet impingement force play a relatively large role on fluid flow in the hybrid welding. Keyhole depth always oscillates within a range. With an increase in laser power, the weld pool behavior becomes more complex. An anti-clockwise vortex is generated and the stability of keyhole depth is improved. Besides, the effects of laser power on different driving forces of fluid flow in weld pool are also discussed.

  7. A Finite-Volume approach for compressible single- and two-phase flows in flexible pipelines with fluid-structure interaction

    Science.gov (United States)

    Daude, F.; Galon, P.

    2018-06-01

    A Finite-Volume scheme for the numerical computations of compressible single- and two-phase flows in flexible pipelines is proposed based on an approximate Godunov-type approach. The spatial discretization is here obtained using the HLLC scheme. In addition, the numerical treatment of abrupt changes in area and network including several pipelines connected at junctions is also considered. The proposed approach is based on the integral form of the governing equations making it possible to tackle general equations of state. A coupled approach for the resolution of fluid-structure interaction of compressible fluid flowing in flexible pipes is considered. The structural problem is solved using Euler-Bernoulli beam finite elements. The present Finite-Volume method is applied to ideal gas and two-phase steam-water based on the Homogeneous Equilibrium Model (HEM) in conjunction with a tabulated equation of state in order to demonstrate its ability to tackle general equations of state. The extensive application of the scheme for both shock tube and other transient flow problems demonstrates its capability to resolve such problems accurately and robustly. Finally, the proposed 1-D fluid-structure interaction model appears to be computationally efficient.

  8. Comparative Analysis of the Solid Phases of Bronchoalveolar Lavage and Oral Fluid in Children with Acute Necrotizing Pneumonia

    Directory of Open Access Journals (Sweden)

    V.N. Grona

    2014-05-01

    Full Text Available The growing number of acute lung abscesses, and pleural empyema, high invalidization and mortality determine the necessity for search of new methods of its diagnosis and treatment. The aim of this research was to study the morphological characteristics of in bronchoalveolar lavage and oral fluid facies in children with acute destructive pneumonias and to find out correlations between them. We examined 24 patients of department of purulent surgery in age from 1 to 14 years. Collection of mixed unstimulated oral fluid was carried out by spitting into special tubes, bronchoalveolar lavage was obtained by bronchoscopy. There has been revealed a correlation between morphological pattern of bronchoalveolar lavage and oral fluid in children depending on the pathological condition of the body.

  9. Cellulose tris-(3,5-dimethylphenylcarbamate)-based chiral stationary phase for the enantioseparation of drugs in supercritical fluid chromatography: comparison with HPLC.

    Science.gov (United States)

    Kalíková, Květa; Martínková, Monika; Schmid, Martin G; Tesařová, Eva

    2018-03-01

    A cellulose tris-(3,5-dimethylphenylcarbamate)-based chiral stationary phase was studied as a tool for the enantioselective separation of 21 selected analytes with different pharmaceutical and physicochemical properties. The enantioseparations were performed using supercritical fluid chromatography. The effect of the mobile phase composition was studied. Four different additives (diethylamine, triethylamine, isopropylamine, and trifluoroacetic acid) and isopropylamine combined with trifluoroacetic acid were tested and their influence on enantioseparation was compared. The influence of two different mobile phase co-solvents (methanol and propan-2-ol) combined with all the additives was also evaluated. The best mobile phase compositions for the separation of the majority of enantiomers were CO 2 /methanol/isopropylamine 80:20:0.1 v/v/v or CO 2 /propan-2-ol/isopropylamine/trifluoroacetic acid 80:20:0.05:0.05 v/v/v/v. The best results were obtained from the group of basic β-blockers. A high-performance liquid chromatography separation system composed of the same stationary phase and mobile phase of similar properties prepared as a mixture of hexane/propan-2-ol/additive 80:20:0.1 v/v/v was considered for comparison. Supercritical fluid chromatography was found to yield better results, i.e. better enantioresolution for shorter analysis times than high-performance liquid chromatography. However, examples of enantiomers better resolved under the optimized conditions in high-performance liquid chromatography were also found. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Experimental investigation of the fluid dynamic efficiency of a high performance multi-valve internal combustion engine during the intake phase: Influence of valve-valve interference phenomena

    Directory of Open Access Journals (Sweden)

    Algieri Angelo

    2013-01-01

    Full Text Available The purpose of the present work is the analysis of the fluid dynamic behavior of a high performance internal combustion engine during the intake phase. In particular, a four-valve spark-ignition engine has been characterized at the steady flow rig. Dimensionless discharge coefficients have been used to define the global fluid dynamic efficiency of the intake system, while the Laser Doppler Anemometry (LDA technique has been employed to evaluate the mean flow in the valve curtain area and to characterise the interference phenomena between the two intake valves. The investigation has shown the significant influence of the valve lift on the volumetric efficiency of the intake apparatus. Moreover, the experimental analysis has highlighted that the valve-valve interference phenomena have a relevant impact on the head breathability, on the flow development within the combustion chamber and on the velocity standard deviations.

  11. Equations of state for the fully flexible WCA chains in the fluid and solid phases based on Wertheims-TPT2

    Science.gov (United States)

    Mirzaeinia, Ali; Feyzi, Farzaneh; Hashemianzadeh, Seyed Majid

    2018-03-01

    Based on Wertheim's second order thermodynamic perturbation theory (TPT2), equations of state (EOSs) are presented for the fluid and solid phases of tangent, freely jointed spheres. It is considered that the spheres interact with each other through the Weeks-Chandler-Anderson (WCA) potential. The developed TPT2 EOS is the sum of a monomeric reference term and a perturbation contribution due to bonding. MC NVT simulations are performed to determine the structural properties of the reference system in the reduced temperature range of 0.6 ≤ T* ≤ 4.0 and the packing fraction range of 0.1 ≤ η ≤ 0.72. Mathematical functions are fitted to the simulation results of the reference system and employed in the framework of Wertheim's theory to develop TPT2 EOSs for the fluid and solid phases. The extended EOSs are compared to the MC NPT simulation results of the compressibility factor and internal energy of the fully flexible chain systems. Simulations are performed for the WCA chain system for chain lengths of up to 15 at T* = 1.0, 1.5, 2.0, 3.0. Across all the reduced temperatures, the agreement between the results of the TPT2 EOS and MC simulations is remarkable. Overall Average Absolute Relative Percent Deviation at T* = 1.0 for the compressibility factor in the entire chain lengths we covered is 0.51 and 0.77 for the solid and fluid phases, respectively. Similar features are observed in the case of residual internal energy.

  12. Equations of state for the fully flexible WCA chains in the fluid and solid phases based on Wertheims-TPT2.

    Science.gov (United States)

    Mirzaeinia, Ali; Feyzi, Farzaneh; Hashemianzadeh, Seyed Majid

    2018-03-14

    Based on Wertheim's second order thermodynamic perturbation theory (TPT2), equations of state (EOSs) are presented for the fluid and solid phases of tangent, freely jointed spheres. It is considered that the spheres interact with each other through the Weeks-Chandler-Anderson (WCA) potential. The developed TPT2 EOS is the sum of a monomeric reference term and a perturbation contribution due to bonding. MC NVT simulations are performed to determine the structural properties of the reference system in the reduced temperature range of 0.6 ≤ T* ≤ 4.0 and the packing fraction range of 0.1 ≤ η ≤ 0.72. Mathematical functions are fitted to the simulation results of the reference system and employed in the framework of Wertheim's theory to develop TPT2 EOSs for the fluid and solid phases. The extended EOSs are compared to the MC NPT simulation results of the compressibility factor and internal energy of the fully flexible chain systems. Simulations are performed for the WCA chain system for chain lengths of up to 15 at T* = 1.0, 1.5, 2.0, 3.0. Across all the reduced temperatures, the agreement between the results of the TPT2 EOS and MC simulations is remarkable. Overall Average Absolute Relative Percent Deviation at T* = 1.0 for the compressibility factor in the entire chain lengths we covered is 0.51 and 0.77 for the solid and fluid phases, respectively. Similar features are observed in the case of residual internal energy.

  13. Supercritical fluid chromatographic resolution of water soluble isomeric carboxyl/amine terminated peptides facilitated via mobile phase water and ion pair formation.

    Science.gov (United States)

    Patel, M A; Riley, F; Ashraf-Khorassani, M; Taylor, L T

    2012-04-13

    Both analytical scale and preparative scale packed column supercritical fluid chromatography (SFC) have found widespread applicability for chiral separations of multiple polar pharmaceutical candidates. However, SFC is rapidly becoming an achiral technique. More specifically, ion pair SFC is finding greater utility for separation of ionic analytes such as amine salts and organic sulfonates. The key to this success is, in part, the incorporation of additives such as trifluoroacetic acid and ammonium acetate into the mobile phase in association with a wide variety of both bonded silica stationary phases and high purity bare silica. Ion pairing SFC coupled with evaporative light scattering detection and mass spectrometric detection is presented here for the separation of water soluble, uncapped, isomeric peptide pairs that differ in amino acid arrangement. The separation is best achieved on either diol-bonded silica or bare silica with 1-5% (w/w) water as a significant ingredient in the mobile phase. Nitrogenous stationary phases such as 2-ethylpyridine, which had been very successful for the separation of capped peptides failed to yield the desired separation regardless of the mobile phase composition. A HILIC type retention mechanism is postulated for the separation of both isomeric uncapped peptide pairs. Copyright © 2012 Elsevier B.V. All rights reserved.

  14. A review of solid-fluid selection options for optical-based measurements in single-phase liquid, two-phase liquid-liquid and multiphase solid-liquid flows

    Science.gov (United States)

    Wright, Stuart F.; Zadrazil, Ivan; Markides, Christos N.

    2017-09-01

    Experimental techniques based on optical measurement principles have experienced significant growth in recent decades. They are able to provide detailed information with high-spatiotemporal resolution on important scalar (e.g., temperature, concentration, and phase) and vector (e.g., velocity) fields in single-phase or multiphase flows, as well as interfacial characteristics in the latter, which has been instrumental to step-changes in our fundamental understanding of these flows, and the development and validation of advanced models with ever-improving predictive accuracy and reliability. Relevant techniques rely upon well-established optical methods such as direct photography, laser-induced fluorescence, laser Doppler velocimetry/phase Doppler anemometry, particle image/tracking velocimetry, and variants thereof. The accuracy of the resulting data depends on numerous factors including, importantly, the refractive indices of the solids and liquids used. The best results are obtained when the observational materials have closely matched refractive indices, including test-section walls, liquid phases, and any suspended particles. This paper reviews solid-liquid and solid-liquid-liquid refractive-index-matched systems employed in different fields, e.g., multiphase flows, turbomachinery, bio-fluid flows, with an emphasis on liquid-liquid systems. The refractive indices of various aqueous and organic phases found in the literature span the range 1.330-1.620 and 1.251-1.637, respectively, allowing the identification of appropriate combinations to match selected transparent or translucent plastics/polymers, glasses, or custom materials in single-phase liquid or multiphase liquid-liquid flow systems. In addition, the refractive indices of fluids can be further tuned with the use of additives, which also allows for the matching of important flow similarity parameters such as density and viscosity.

  15. Flow Characterization of Vapor Phase of Geothermal Fluid in Pipe Using Isotope 85Kr and Residence Time Distribution Modeling

    Directory of Open Access Journals (Sweden)

    S. Sugiharto

    2014-08-01

    Full Text Available Measurement of vapor flow in geothermal pipe faces great challenges due to fast fluids flow in high-temperature and high-pressure environment. In present study the flow rate measurement has been performed to characterization the geothermal vapor flow in a pipe. The experiment was carried out in a pipe which is connected to a geothermal production well, KMJ-14. The pipe has a 10” outside diameter and contains dry vapor at a pressure of 8 kg/cm2 and a temperature of 170 oC. Krypton-85 gas isotope (85Kr has been injected into the pipe. Three collimated radiation detectors positioned respectively at 127, 177 and 227m from injection point were used to obtain experimental data which represent radiotracer residence time distribution (RTD in the pipe. The last detector at the position of 227 m did not respond, which might be due to problems in cable connections. Flow properties calculated using mean residence time (MRT shows that the flow rate of the vapor in pipe is 10.98 m/s, much faster than fluid flow commonly found in various industrial process plants. Best fitting evaluated using dedicated software developed by IAEA expert obtained the Péclet number Pe as 223. This means that the flow of vapor of geothermal fluids in pipe is plug flow in character. The molecular diffusion coefficient is 0.45 m2/s, calculated from the axial dispersion model.

  16. A study on the performance of condensation heat transfer for various working fluid of two-phase closed thermosyphons with various helical grooves

    International Nuclear Information System (INIS)

    Han, Kyu Il; Cho, Dong Hyun

    2005-01-01

    This study concerns the performance of condensing heat transfer in two-phase closed thermosyphons with various helical grooves. Distilled water, methanol, ethanol have been used as the working fluid. In the present work, a copper tube of the length of 1200mm and 14.28mm of inside diameter is used as the container of the thermosyphon. Each of the evaporator and the condenser section has a length of 550mm, while the remaining part of the thermosyphon tube is adiabatic section. A experimental study was carried out for analyzing the performances of having 50, 60, 70, 80, 90 helical grooves. A plain thermosyphon having the same inner and outer diameter as the grooved thermosyphons is also tested for the comparison. The type of working fluid and the numbers of grooves of the thermosyphons with various helical grooves have been used as the experimental parameters. The experimental results have been assessed and compared with existing theories. The results show that the type of working fluids are very important factors for the operation of thermosyphons. And the maximum enhancement (i.e. the ratio of the heat transfer coefficients the helical thermosyphons to plain thermosyphons) is 1.5∼2 for condensation

  17. An energy stable evolution method for simulating two-phase equilibria of multi-component fluids at constant moles, volume and temperature

    KAUST Repository

    Kou, Jisheng

    2016-02-25

    In this paper, we propose an energy-stable evolution method for the calculation of the phase equilibria under given volume, temperature, and moles (VT-flash). An evolution model for describing the dynamics of two-phase fluid system is based on Fick’s law of diffusion for multi-component fluids and the Peng-Robinson equation of state. The mobility is obtained from diffusion coefficients by relating the gradient of chemical potential to the gradient of molar density. The evolution equation for moles of each component is derived using the discretization of diffusion equations, while the volume evolution equation is constructed based on the mechanical mechanism and the Peng-Robinson equation of state. It is proven that the proposed evolution system can well model the VT-flash problem, and moreover, it possesses the property of total energy decay. By using the Euler time scheme to discretize this evolution system, we develop an energy stable algorithm with an adaptive choice strategy of time steps, which allows us to calculate the suitable time step size to guarantee the physical properties of moles and volumes, including positivity, maximum limits, and correct definition of the Helmhotz free energy function. The proposed evolution method is also proven to be energy-stable under the proposed time step choice. Numerical examples are tested to demonstrate efficiency and robustness of the proposed method.

  18. Purification of lignans from Fructus Arctii using off-line two-dimensional supercritical fluid chromatography/reversed-phase liquid chromatography.

    Science.gov (United States)

    Yang, Bichao; Xin, Huaxia; Wang, Feier; Cai, Jianfeng; Liu, Yanfang; Fu, Qing; Jin, Yu; Liang, Xinmiao

    2017-08-01

    As a common traditional Chinese medicine, Fructus Arctii has important clinical medical values. Its main components are lignans, which are difficult to separate and analyze because of the complex composition, similar chemical structures, and close properties. In this study, an off-line two-dimensional supercritical fluid chromatography/reversed-phase liquid chromatography method, as well as an effective sample pretreatment method based on hydrophilic interaction chromatography material, was developed to enrich the minor lignan fractions and obtain high-purity compounds. In total, 12 high-purity compounds were isolated from Fructus Arctii. Their structures were identified by using high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy, which showed that all were lignans and that most of them were isomers. The results demonstrated the effective off-line two-dimensional supercritical fluid chromatography/reversed-phase liquid chromatography method for the purification of lignans from Fructus Arctii. The separation protocol established here will be beneficial for the separation of complex samples from other kinds of natural products. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Phase-coexistence simulations of fluid mixtures by the Markov Chain Monte Carlo method using single-particle models

    KAUST Repository

    Li, Jun; Calo, Victor M.

    2013-01-01

    models although its deviation in the liquid phase is greater. Since the single-particle model reduces the particle number and avoids the time-consuming Ewald summation used to evaluate Coulomb interactions, the proposed model improves the computational

  20. Integration of two-phase solid fluid equations in a catchment model for flashfloods, debris flows and shallow slope failures

    KAUST Repository

    Bout, B.; Lombardo, Luigi; van Westen, C.J.; Jetten, V.G.

    2018-01-01

    An integrated, modeling method for shallow landslides, debris flows and catchment hydrology is developed and presented in this paper. Existing two-phase debris flow equations and an adaptation on the infinite slope method are coupled with a full

  1. ANALYSIS OF BASIC PSYCHOTROPIC DRUGS IN BIOLOGICAL FLUIDS AND TISSUES BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY.

    Science.gov (United States)

    Petruczynik, Anna; Waksmundzka-Hajnos, Monika

    2017-03-01

    The review of the RP HPLC analysis of basic psychotropic drugs is presented. It contains sample preparation methods with centrifugation, protein precipitation, liquid-liquid extraction (LLE), dispersive liquid-liquid microextraction (DLLME), solid-phase extraction (SPE), solid-phase microextraction (SPME), microwave-assisted extraction (MAE) and RP-HPLC analysis. Chromatographic behavior of basic drugs in aqueous media - eluents used in reversed phase systems is discussed. Methods of blocking of residue surface silanols' interaction are mentioned. Analytical methods used for the analysis are divided into parts according with the above methods: the use of low-pH eluents, the use of high-pH eluents, the use of silanol blockers, special stationary phases for basic analytes. Literature connected with the sample preparation methods and analytical systems for the drug analysis are cited in details and presented also in Table 1.

  2. Study of the phenomena of crystallization of paraffin in the fluid-dynamic behavior of paraffinic crude - Phase 1

    International Nuclear Information System (INIS)

    Rodriguez, L; Castaneda, M

    2001-01-01

    The results obtained by relating the formation of wax crystals using traditional measurements such as cloud point, pour point and viscosity show the importance of analyzing the interactions among the chemical nature of crude oils, the physical-chemical variables and the fluid dynamics that cause different shapes and rates of crystallization. In addition, the specific value of viscosity should be measured at a certain temperature, as well as the rheological behavior of the crude oils during the process of formation and destruction of crystals due to shear rate. In order to carry out this study, a group of waxy crude oils was chosen. They were characterized considering the parameters mentioned above, and they were subjected to different cooling rates to microscopically observe the resulting morphologies, and to relate them to rheological behavior in a range of similar conditions that are obtained during hydrocarbon transport through pipelines. For this effect, laboratory tests were carried out, in addition to the scaling of results at the pilot plant level in a simulator to analyze the behavior of the fluids in dynamic or static conditions, in relation to prolonged pipeline downtime. This type of studies improves operational safety, offers considerable savings on additives, power, an increase in pumping capacity, and it also facilitates the selection of the most appropriate technology to control wax deposition

  3. Phase separation of a Lennard-Jones fluid interacting with a long, condensed polymer chain: implications for the nuclear body formation near chromosomes.

    Science.gov (United States)

    Oh, Inrok; Choi, Saehyun; Jung, YounJoon; Kim, Jun Soo

    2015-08-28

    Phase separation in a biological cell nucleus occurs in a heterogeneous environment filled with a high density of chromatins and thus it is inevitably influenced by interactions with chromatins. As a model system of nuclear body formation in a cell nucleus filled with chromatins, we simulate the phase separation of a low-density Lennard-Jones (LJ) fluid interacting with a long, condensed polymer chain. The influence of the density variation of LJ particles above and below the phase boundary and the role of attractive interactions between LJ particles and polymer segments are investigated at a fixed value of strong self-interaction between LJ particles. For a density of LJ particles above the phase boundary, phase separation occurs and a dense domain of LJ particles forms irrespective of interactions with the condensed polymer chain whereas its localization relative to the polymer chain is determined by the LJ-polymer attraction strength. Especially, in the case of moderately weak attractions, the domain forms separately from the polymer chain and subsequently associates with the polymer chain. When the density is below the phase boundary, however, the formation of a dense domain is possible only when the LJ-polymer attraction is strong enough, for which the domain grows in direct contact with the interacting polymer chain. In this work, different growth behaviors of LJ particles result from the differences in the density of LJ particles and in the LJ-polymer interaction, and this work suggests that the distinct formation of activity-dependent and activity-independent nuclear bodies (NBs) in a cell nucleus may originate from the differences in the concentrations of body-specific NB components and in their interaction with chromatins.

  4. Fluid phase equilibria of the reaction mixture during the selective hydrogenation of 2-butenal in dense carbon dioxide

    DEFF Research Database (Denmark)

    Musko, Nikolai; Jensen, Anker Degn; Baiker, Alfons

    2012-01-01

    Knowledge of the phase behaviour and composition is of paramount importance for understanding multiphase reactions. We have investigated the effect of the phase behaviour in the palladium-catalysed selective hydrogenation of 2-butenal to saturated butanal in dense carbon dioxide. The reactions were...... cell. The results of the catalytic experiments showed that small amounts of carbon dioxide added to the system significantly decrease the conversion, whereas at higher loadings of CO2 the reaction rate gradually increases reaching a maximum. The CPA calculations revealed that this maximum is achieved...... performed using a 5wt% Pd on activated carbon in custom-designed high pressure autoclaves at 323K. The Cubic-Plus-Association (CPA) equation of state was employed to model the phase behaviour of the experimentally studied systems. CPA binary interaction parameters were estimated based on the experimental...

  5. Fluid-sensitive nanoscale switching with quantum levitation controlled by α -Sn/β -Sn phase transition

    Science.gov (United States)

    Boström, Mathias; Dou, Maofeng; Malyi, Oleksandr I.; Parashar, Prachi; Parsons, Drew F.; Brevik, Iver; Persson, Clas

    2018-03-01

    We analyze the Lifshitz pressure between silica and tin separated by a liquid mixture of bromobenzene and chlorobenzene. We show that the phase transition from semimetallic α -Sn to metallic β -Sn can switch Lifshitz forces from repulsive to attractive. This effect is caused by the difference in dielectric functions of α -Sn and β -Sn , giving both attractive and repulsive contributions to the total Lifshitz pressure in different frequency regions controlled by the composition of the intervening liquid mixture. In this way, one may be able to produce phase-transition-controlled quantum levitation in a liquid medium.

  6. Exploration of the phase diagram of liquid water in the low-temperature metastable region using synthetic fluid inclusions

    DEFF Research Database (Denmark)

    Qiu, Chen; Krüger, Yves; Wilke, Max

    2016-01-01

    water with a density of 0.921 kg/m3 remains in a homogeneous state during cooling down to the temperaure of −30.5 °C, where it is transformed into ice whose density corresponds to zero pressure. iii) ice melting. Ice melting temperatures of up to 6.8 °C were measured in absence of the vapour bubble, i......We present new experimental data of the low-temperature metastable region of liquid water derived from high-density synthetic fluid inclusions (996−916 kg/m3) in quartz. Microthermometric measurements include: i) Prograde (upon heating) and retrograde (upon cooling) liquid-vapour homogenisation. We...

  7. Critical phenomena in binary fluid mixtures : Classification of phase equilibria with the simplified-perturbed-hard-chain theory

    NARCIS (Netherlands)

    Van Pelt, A.

    1992-01-01

    I. INTRODUCTION AND THEORY This PhD research is mainly concerned with the global phase behaviour, that is calculated from the Simplified-Perturbed-Hard-Chain equation. This equation distinguishes itself from many other equations of state by a sound theoretical background. We enter the field of the

  8. Generic solid phase extraction-liquid chromatography-tandem mass spectrometry method for fast determination of drugs in biological fluids

    NARCIS (Netherlands)

    Schellen, A.; Ooms, B.; Lagemaat, D. van de; Vreeken, R.; Dongen, W.D. van

    2003-01-01

    A generic method was developed for the fast determination of a wide range of drugs in serum or plasma. The methodology comprises generic solid-phase extraction, on-line coupled to gradient HPLC with tandem mass spectrometric detection (SPE-LC-MS/MS). The individual components of the SPE-LC-MS/MS

  9. Drift flux model as approximation of two fluid model for two phase dispersed and slug flow in tube

    Energy Technology Data Exchange (ETDEWEB)

    Nigmatulin, R.I.

    1995-09-01

    The analysis of one-dimensional schematizing for non-steady two-phase dispersed and slug flow in tube is presented. Quasi-static approximation, when inertia forces because of the accelerations of the phases may be neglected, is considered. Gas-liquid bubbly and slug vertical upward flows are analyzed. Non-trivial theoretical equations for slip velocity for these flows are derived. Juxtaposition of the derived equations for slip velocity with the famous Zuber-Findlay correlation as cross correlation coefficients is criticized. The generalization of non-steady drift flux Wallis theory taking into account influence of wall friction on the bubbly or slug flows for kinematical waves is considered.

  10. Drift flux model as approximation of two fluid model for two phase dispersed and slug flow in tube

    International Nuclear Information System (INIS)

    Nigmatulin, R.I.

    1995-01-01

    The analysis of one-dimensional schematizing for non-steady two-phase dispersed and slug flow in tube is presented. Quasi-static approximation, when inertia forces because of the accelerations of the phases may be neglected, is considered. Gas-liquid bubbly and slug vertical upward flows are analyzed. Non-trivial theoretical equations for slip velocity for these flows are derived. Juxtaposition of the derived equations for slip velocity with the famous Zuber-Findlay correlation as cross correlation coefficients is criticized. The generalization of non-steady drift flux Wallis theory taking into account influence of wall friction on the bubbly or slug flows for kinematical waves is considered

  11. Solid-phase/supercritical-fluid extraction for liquid chromatography of phenolic compounds in freshwater microalgae and selected cyanobacterial species

    Czech Academy of Sciences Publication Activity Database

    Klejdus, B.; Kopecký, Jiří; Benešová, L.; Vacek, J.

    2009-01-01

    Roč. 1216, č. 5 (2009), s. 763-771 ISSN 0021-9673 R&D Projects: GA ČR GA525/07/0338 Grant - others:CZ(CZ) GP525/08/P540 Institutional research plan: CEZ:AV0Z50200510 Keywords : methanol * solid-phase extraction * phenolic compounds Subject RIV: EE - Microbiology, Virology Impact factor: 4.101, year: 2009

  12. A Designer Fluid for Aluminum Phase Change Devices, Vol. 1 of 3: General Inorganic Aqueous Solution (IAS) Chemistry

    Science.gov (United States)

    2016-11-17

    out in wicked phase change heat transfer devices. Wen [18] used nanoparticle suspensions to successfully increase the boiling heat transfer...Aqueous Solution of an Anionic Surfactant,” Journal of Heat Transfer 122, No. 4: 708. [18] Wen , D. and Ding, Y., 2005, “Experimental Investigation...Li, Y., 1974, “Diffusion of Ions in Sea Water and in Deep -Sea Sediments,” Geochimica et Cosmochimica Acta, Vol. 88, pp. 703-714. [36] Negishi, K

  13. Phase-coexistence simulations of fluid mixtures by the Markov Chain Monte Carlo method using single-particle models

    KAUST Repository

    Li, Jun

    2013-09-01

    We present a single-particle Lennard-Jones (L-J) model for CO2 and N2. Simplified L-J models for other small polyatomic molecules can be obtained following the methodology described herein. The phase-coexistence diagrams of single-component systems computed using the proposed single-particle models for CO2 and N2 agree well with experimental data over a wide range of temperatures. These diagrams are computed using the Markov Chain Monte Carlo method based on the Gibbs-NVT ensemble. This good agreement validates the proposed simplified models. That is, with properly selected parameters, the single-particle models have similar accuracy in predicting gas-phase properties as more complex, state-of-the-art molecular models. To further test these single-particle models, three binary mixtures of CH4, CO2 and N2 are studied using a Gibbs-NPT ensemble. These results are compared against experimental data over a wide range of pressures. The single-particle model has similar accuracy in the gas phase as traditional models although its deviation in the liquid phase is greater. Since the single-particle model reduces the particle number and avoids the time-consuming Ewald summation used to evaluate Coulomb interactions, the proposed model improves the computational efficiency significantly, particularly in the case of high liquid density where the acceptance rate of the particle-swap trial move increases. We compare, at constant temperature and pressure, the Gibbs-NPT and Gibbs-NVT ensembles to analyze their performance differences and results consistency. As theoretically predicted, the agreement between the simulations implies that Gibbs-NVT can be used to validate Gibbs-NPT predictions when experimental data is not available. © 2013 Elsevier Inc.

  14. [Models for quantification of fluid saturation in two-phase flow system by light transmission method and its application].

    Science.gov (United States)

    Zhang, Yan-Hong; Ye, Shu-Jun; Wu, Ji-Chun

    2014-06-01

    Based on light transmission method in quantification of liquid saturation and its application in two-phase flow system, two groups of sandbox experiments were set up to study the migration of gas or Dense Non-Aqueous Phase Liquids (DNAPLs) in water saturated porous media. The migration of gas or DNAPL was monitored in the study. Two modified Light Intensity-Saturation (LIS) models for water/gas two-phase system were applied and verified by the experiment data. Moreover two new LIS models for NAPL/water system were developed and applied to simulate the DNAPL infiltration experiment data. The gas injection experiment showed that gas moved upward to the top of the sandbox in the form of 'fingering' and finally formed continuous distribution. The results of DNAPL infiltration experiment showed that TCE mainly moved downward as the result of its gravity, eventually formed irregular plume and accumulated at the bottom of the sandbox. The outcomes of two LIS models for water/gas system (WG-A and WG-B) were consistent to the measured data. The results of two LIS models for NAPL/water system (NW-A and NW-B) fit well with the observations, and Model NW-A based on assumption of individual drainage gave better results. It could be a useful reference for quantification of NAPL/water saturation in porous media system.

  15. [Determination of ferulic acid in chuanxiong and in animal serum and cerebrospinal fluid by reversed-phase high performance liquid chromatography].

    Science.gov (United States)

    Lü, K; Ding, M Y; Li, H X; Liu, D L

    2000-11-01

    An easy, rapid and sensitive method for the determination of ferulic acid(FA) in Chuanxiong extracts, animal (mouse) serum and cerebrospinal fluid by RP-HPLC has been developed. The FA was separated on an ODS column, Nova-Pak C18(3.9 mm i.d. x 150 mm) and detected at the wavelength of 320 nm. The mobile phase was methanol-water-acetic acid (35:65:0.5, V/V), with a flow rate of 0.8 mL/min. The detection limit of FA was 1.7 micrograms/L(S/N = 3) and the calibration curve was linear within the range of 0.85 mg/L-4.00 mg/L(r = 0.99904, n = 6). The mean recovery from animal serum and cerebrospinal was 95%-102%.

  16. Sensitive, automatic method for the determination of diazepam and its five metabolites in human oral fluid by online solid-phase extraction and liquid chromatography with tandem mass spectrometry

    DEFF Research Database (Denmark)

    Jiang, Fengli; Rao, Yulan; Wang, Rong

    2016-01-01

    A novel and simple online solid-phase extraction liquid chromatography-tandem mass spectrometry method was developed and validated for the simultaneous determination of diazepam and its five metabolites including nordazepam, oxazepam, temazepam, oxazepam glucuronide, and temazepam glucuronide...... in human oral fluid. Human oral fluid was obtained using the Salivette(®) collection device, and 100 μL of oral fluid samples were loaded onto HySphere Resin GP cartridge for extraction. Analytes were separated on a Waters Xterra C18 column and quantified by liquid chromatography with tandem mass...

  17. Tumor interstitial fluid

    DEFF Research Database (Denmark)

    Gromov, Pavel; Gromova, Irina; Olsen, Charlotta J.

    2013-01-01

    Tumor interstitial fluid (TIF) is a proximal fluid that, in addition to the set of blood soluble phase-borne proteins, holds a subset of aberrantly externalized components, mainly proteins, released by tumor cells and tumor microenvironment through various mechanisms, which include classical...

  18. Supercritical fluid reverse micelle separation

    Science.gov (United States)

    Fulton, J.L.; Smith, R.D.

    1993-11-30

    A method of separating solute material from a polar fluid in a first polar fluid phase is provided. The method comprises combining a polar fluid, a second fluid that is a gas at standard temperature and pressure and has a critical density, and a surfactant. The solute material is dissolved in the polar fluid to define the first polar fluid phase. The combined polar and second fluids, surfactant, and solute material dissolved in the polar fluid is maintained under near critical or supercritical temperature and pressure conditions such that the density of the second fluid exceeds the critical density thereof. In this way, a reverse micelle system defining a reverse micelle solvent is formed which comprises a continuous phase in the second fluid and a plurality of reverse micelles dispersed in the continuous phase. The solute material is dissolved in the polar fluid and is in chemical equilibrium with the reverse micelles. The first polar fluid phase and the continuous phase are immiscible. The reverse micelles each comprise a dynamic aggregate of surfactant molecules surrounding a core of the polar fluid. The reverse micelle solvent has a polar fluid-to-surfactant molar ratio W, which can vary over a range having a maximum ratio W[sub o] that determines the maximum size of the reverse micelles. The maximum ratio W[sub o] of the reverse micelle solvent is then varied, and the solute material from the first polar fluid phase is transported into the reverse micelles in the continuous phase at an extraction efficiency determined by the critical or supercritical conditions. 27 figures.

  19. Cold distribution networks. Cold distribution by two-phase refrigerant fluid. Case of ice slurries; Reseaux de distribution de froid. Distribution de froid par fluide frigoporteur diphasique. Cas du coulis de glace stabilisee (2002 - 2004). Rapport final (1er juillet 2004). Programme energie. PRI 9.1

    Energy Technology Data Exchange (ETDEWEB)

    Lallemand, A. [Institut National des Sciences Appliquees (INSA), Centre de Thermique de Lyon (CETHIL), UMR 5008, 69 - Villeurbanne (France); Mercier, P. [CEA Grenoble, Groupement pour la Recherche sur les Echangeurs Thermiques (GRETH), 38 (France); Royon, L. [Paris-1 Univ., Lab. de Biorheologie et d' Hydrodynamique Physico-Chimique, 75 (France); Dumas, J.P. [L' Ecole Nationale Superieure en Genie des Technologies Industrielles, Lab. de Thermique Energetique et Procedes, 64 - Pau (France); Guilpart, J. [URGPAN/CEMAGRE, 33 - Bordeaux (France)

    2004-07-01

    This PRI aims to participate to the development of alternate solutions for refrigerant fluids, for the cold transport and more specially a two phase refrigerant fluid: the stabilized ice slurry. The research program presented three main axis: design, realization and characterization of stabilized ice slurry, experimental studies of transport and transfer properties, study of online measurement process of the solid content. A simulation has been realized to evaluate the energy efficiency of this refrigerant use. (A.L.B.)

  20. ECO2M: A TOUGH2 Fluid Property Module for Mixtures of Water, NaCl, and CO2, Including Super- and Sub-Critical Conditions, and Phase Change Between Liquid and Gaseous CO2

    Energy Technology Data Exchange (ETDEWEB)

    Pruess, K.

    2011-04-01

    ECO2M is a fluid property module for the TOUGH2 simulator (Version 2.0) that was designed for applications to geologic storage of CO{sub 2} in saline aquifers. It includes a comprehensive description of the thermodynamics and thermophysical properties of H{sub 2}O - NaCl - CO{sub 2} mixtures, that reproduces fluid properties largely within experimental error for temperature, pressure and salinity conditions in the range of 10 C {le} T {le} 110 C, P {le} 600 bar, and salinity from zero up to full halite saturation. The fluid property correlations used in ECO2M are identical to the earlier ECO2N fluid property package, but whereas ECO2N could represent only a single CO{sub 2}-rich phase, ECO2M can describe all possible phase conditions for brine-CO{sub 2} mixtures, including transitions between super- and sub-critical conditions, and phase change between liquid and gaseous CO{sub 2}. This allows for seamless modeling of CO{sub 2} storage and leakage. Flow processes can be modeled isothermally or non-isothermally, and phase conditions represented may include a single (aqueous or CO{sub 2}-rich) phase, as well as two-and three-phase mixtures of aqueous, liquid CO{sub 2} and gaseous CO{sub 2} phases. Fluid phases may appear or disappear in the course of a simulation, and solid salt may precipitate or dissolve. TOUGH2/ECO2M is upwardly compatible with ECO2N and accepts ECO2N-style inputs. This report gives technical specifications of ECO2M and includes instructions for preparing input data. Code applications are illustrated by means of several sample problems, including problems that had been previously solved with TOUGH2/ECO2N.

  1. Reflooding phase of the LOCA - state of the art I. Heat transfer and fluid flow during reflooding

    International Nuclear Information System (INIS)

    Yadigaroglu, G.

    1977-01-01

    Complex heat transfer processes take place during the reflooding phase of the Loss-of-Coolant Accident in Light-Water Reactors. Reflooding experiments conducted with simple single-channel geometries (round tubes and annuli) and with rod bundles are reviewed. The experimental findings and various parametric trends are critically discussed, explained, and summarized. Analytical methods that are in use in safety analysis and features of advanced models that have been proposed are outlined. These advanced models attempt to solve the conservation equations in the core channels in order to find the local coolant conditions. The values of the heat transfer coefficients are related to local parameters to arrive at cladding temperature predictions

  2. Contribution to numerical methods for all Mach flow regimes and to fluid-porous coupling for the simulation of homogeneous two-phase flows in nuclear reactors

    International Nuclear Information System (INIS)

    Zaza, Chady

    2015-01-01

    The numerical simulation of steam generators of pressurized water reactors is a complex problem, involving different flow regimes and a wide range of length and time scales. An accidental scenario may be associated with very fast variations of the flow with an important Mach number. In contrast in the nominal regime the flow may be stationary, at low Mach number. Moreover whatever the regime under consideration, the array of U-tubes is modelled by a porous medium in order to avoid taking into account the complex geometry of the steam generator, which entails the issue of the coupling conditions at the interface with the free-fluid. We propose a new pressure-correction scheme for cell-centered finite volumes for solving the compressible Navier-Stokes and Euler equations at all Mach number. The existence of a discrete solution, the consistency of the scheme in the Lax sense and the positivity of the internal energy were proved. Then the scheme was extended to the homogeneous two-phase flow models of the GENEPI code developed at CEA. Lastly a multigrid-AMR algorithm was adapted for using our pressure-correction scheme on adaptive grids. Regarding the second issue addressed in this work, the numerical simulation of a fluid flow over a porous bed involves very different length scales. Macroscopic interface models - such as Ochoa-Tapia-Whitaker or Beavers-Joseph law for a viscous flow - represent the transition region between the free-fluid and the porous region by an interface of discontinuity associated with specific transmission conditions. An extension to the Beavers-Joseph law was proposed for the convective regime. By introducing a jump in the kinetic energy at the interface, we recover an interface condition close to the Beavers-Joseph law but with a non-linear slip coefficient, which depends on the free-fluid velocity at the interface and on the Darcy velocity. The validity of this new transmission condition was assessed with direct numerical simulations at

  3. Analysis of linear stability in nuclear systems associated to two-phase fluid flow and in thermodynamic balance

    International Nuclear Information System (INIS)

    Galvao, O.B.; Amorim, E.S. do; D'Oliveira, A.B.

    1981-03-01

    Under special conditions a water-cooled reactor or other multiphase process can be subject to instabilities as the so called density-wave oscillations phenomenon. The purpose of this investigation is to derive the stability limits of a boiling channel for the dynamic response to an inlet velocity perturbation. The solution scheme allowed a coupling for the single and two-phase regions together with a model for the dynamic thermal response of the heated surface. The frequency response of a rational transfer function is obtained and a Nyquist plot is used for stability analysis. The model is, although simplified, quite capable of predicting the threshold for self-excited system or the trends given by more exact solution. (Author) [pt

  4. Generic solid phase extraction-liquid chromatography-tandem mass spectrometry method for fast determination of drugs in biological fluids.

    Science.gov (United States)

    Schellen, Anniek; Ooms, Bert; van de Lagemaat, Dick; Vreeken, Rob; van Dongen, William D

    2003-05-25

    A generic method was developed for the fast determination of a wide range of drugs in serum or plasma. The methodology comprises generic solid-phase extraction, on-line coupled to gradient HPLC with tandem mass spectrometric detection (SPE-LC-MS/MS). The individual components of the SPE-LC-MS/MS system were optimized in an integrated approach to maximize the application range and minimize the method development time. The optimized generic SPE-LC-MS/MS protocol was evaluated for 11 drugs with different physicochemical properties. Good quantification for 10 out of 11 of the pharmaceuticals in serum or plasma could be readily achieved. The quantitative assays gave recoveries better than 95%, lower quantification limits of 0.2-2.0 ng/ml, acceptable precision and accuracy and good linearity over 2-4 orders of magnitude. Carry-over was determined to be in the range of 0.02-0.10%, without optimization.

  5. Integration of two-phase solid fluid equations in a catchment model for flashfloods, debris flows and shallow slope failures

    KAUST Repository

    Bout, B.

    2018-04-09

    An integrated, modeling method for shallow landslides, debris flows and catchment hydrology is developed and presented in this paper. Existing two-phase debris flow equations and an adaptation on the infinite slope method are coupled with a full hydrological catchment model. We test the approach on the 4 km2 Scaletta catchment, North-Eastern Sicily, where the 1-10-2009 convective storm caused debris flooding after 395 shallow landslides. Validation is done based on the landslide inventory and photographic evidence from the days after the event. Results show that the model can recreate the impact of both shallow landslides, debris flow runout, and debris floods with acceptable accuracy (91 percent inventory overlap with a 0.22 Cohens Kappa). General patterns in slope failure and runout are well-predicted, leading to a fully physically based prediction of rainfall induced debris flood behavior in the downstream areas, such as the creation of a debris fan at the coastal outlet.

  6. Fluid-phase immunoradiometric assay for the detection of qualitative abnormalities of factor VIII/von Willebrand factor in variants of von Willebrand's disease

    International Nuclear Information System (INIS)

    Girma, J.P.; Ardaillou, N.; Meyer, D.; Lavergne, J.M.; Larrieu, M.J.

    1979-01-01

    Antigenic reactivity of F.VIII/WF in variants of von Willebrand's disease (vWd) was studied with both fluid-phase and solid-phase immunoradiometric assays. Two different (rabbit and goat) 125 I-labeled specific antibodies against purified F.VIII/WF were used in both their divalent (lgG) and their monovalent (Fab fragment) forms. Dose-response curves obtained by reacting a constant amount of antibody with serial dilutions of plasmas from normal or homozygous vWd demonstrated the specificity of the test. The accuracy was significantly higher with 125 I-Fab fragments of goat anti-F.VIII/WF antiserum than intact goat lgG or rabbit lgG or Fab fragments. The significant decrease of the slope of the dose-response curves obtained with plasma from variants of vWd has been interpreted as due to the presence of abnormal F.VIII/WF molecules with decreased antigenic reactivity. A similar anomaly was found in cryosupernatant prepared from normal plasma, paralleling similarities demonstrated between variants of vWd and cryosupernatant. Results of experiments performed by reacting constant plasma dilutions from control or variants of vWd and varying concentrations of anti-F.VIII/WF Fab fragments (rabbit or goat) confirmed the decreased antigenic reactivity of variant F.VIII/WF

  7. Design and Development of a Sub-Zero Fluid System for Demonstration of Orion's Phase Change Material Heat Exchangers on ISS

    Science.gov (United States)

    Sheth, Rubik B.; Ahlstrom, Thomas D.; Le, Hung V.

    2016-01-01

    NASA's Orion Multipurpose Crew Vehicle's Exploration Mission 2 is expected to loiter in Lunar orbit for a relatively long period of time. In low Lunar orbit (LLO) the thermal environment is cyclic - extremely cold in the eclipse and relatively hot near the subsolar point. Phase change material heat exchangers (PCM HXs) are the best option for long term missions in these environments. A PCM HX allows a vehicle to store excess waste energy by thawing a phase change material such as n-pentadecane wax. During portions of the orbit that are extremely cold, the excess energy is rejected, resolidifying the wax. Due to the inherent risk of compromising the heat exchanger during multiple freeze and thaw cycles, a unique payload was designed for the International Space Station to test and demonstration the functions of a PCM HX. The payload incorporates the use of a pumped fluid system and a thermoelectric heat exchanger to promote the freezing and thawing of the PCM HX. This paper shall review the design and development undertaken to build such a system.

  8. Vertical pneumatic conveying in dilute and dense-phase flows: experimental study of the influence of particle density and diameter on fluid dynamic behavior

    Directory of Open Access Journals (Sweden)

    Narimatsu C.P.

    2001-01-01

    Full Text Available In this work, the effects of particle size and density on the fluid dynamic behavior of vertical gas-solid transport of Group D particles in a 53.4 mm diameter transport tube were studied. For the conditions tested, the experimental curves of pressure gradient versus air velocity presented a minimum pressure gradient point, which is associated with a change in the flow regime from dense to dilute phase. The increases in particle size from 1.00 to 3.68 mm and in density from 935 to 2500 kg/m³ caused an increase in pressure gradient for the dense-phase transport region, but were not relevant in dilute transport. The transition velocity between dense and dilute flow (Umin also increased with increasing particle density and diameter. An empirical equation was fitted for predicting transition air velocity for the transport of glass spheres. Additional experiments, covering a wider range of conditions and particles properties, are still needed to allow the fitting of a generalized equation for prediction of Umin.

  9. Formation of intermetallic phases in AlSi7Fe1 alloy processed under microgravity and forced fluid flow conditions and their influence on the permeability

    Science.gov (United States)

    Steinbach, S.; Ratke, L.; Zimmermann, G.; Budenkova, O.

    2016-03-01

    Ternary Al-6.5wt.%Si-0.93wt.%Fe alloy samples were directionally solidified on-board of the International Space Station ISS in the ESA payload Materials Science Laboratory (MSL) equipped with Low Gradient Furnace (LGF) under both purely diffusive and stimulated convective conditions induced by a rotating magnetic field. Using different analysis techniques the shape and distribution of the intermetallic phase β-Al5SiFe in the dendritic microstructure was investigated, to study the influence of solidification velocity and fluid flow on the size and spatial arrangement of intermetallics. Deep etching as well as 3-dimensional computer tomography measurements characterized the size and the shape of β-Al5SiFe platelets: Diffusive growth results in a rather homogeneous distribution of intermetallic phases, whereas forced flow promotes an increase in the amount and the size of β-Al5SiFe platelets in the centre region of the samples. The β-Al5SiFe intermetallics can form not only simple platelets, but also be curved, branched, crossed, interacting with dendrites and porosity located. This leads to formation of large and complex groups of Fe-rich intermetallics, which reduce the melt flow between dendrites leading to lower permeability of the mushy zone and might significantly decrease feeding ability in castings.

  10. Magnetic micro-solid-phase extraction based on magnetite-MCM-41 with gas chromatography-mass spectrometry for the determination of antidepressant drugs in biological fluids.

    Science.gov (United States)

    Kamaruzaman, Sazlinda; Sanagi, Mohd Marsin; Yahaya, Noorfatimah; Wan Ibrahim, Wan Aini; Endud, Salasiah; Wan Ibrahim, Wan Nazihah

    2017-11-01

    A new facile magnetic micro-solid-phase extraction coupled to gas chromatography and mass spectrometry detection was developed for the extraction and determination of selected antidepressant drugs in biological fluids using magnetite-MCM-41 as adsorbent. The synthesized sorbent was characterized by several spectroscopic techniques. The maximum extraction efficiency for extraction of 500 μg/L antidepressant drugs from aqueous solution was obtained with 15 mg of magnetite-MCM-41 at pH 12. The analyte was desorbed using 100 μL of acetonitrile prior to gas chromatography determination. This method was rapid in which the adsorption procedure was completed in 60 s. Under the optimized conditions using 15 mL of antidepressant drugs sample, the calibration curve showed good linearity in the range of 0.05-500 μg/L (r 2  = 0.996-0.999). Good limits of detection (0.008-0.010 μg/L) were obtained for the analytes with good relative standard deviations of solid-phase extraction with gas chromatography and mass spectrometry is a convenient, fast, and economical method for the extraction and determination of amitriptyline and chlorpromazine in biological samples. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Supercritical fluid chromatography versus high performance liquid chromatography for enantiomeric and diastereoisomeric separations on coated polysaccharides-based stationary phases: Application to dihydropyridone derivatives.

    Science.gov (United States)

    Hoguet, Vanessa; Charton, Julie; Hecquet, Paul-Emile; Lakhmi, Chahinaze; Lipka, Emmanuelle

    2018-05-11

    For analytical applications, SFC has always remained in the shadow of LC. Analytical enantioseparation of eight dihydropyridone derivatives, was run in both High Performance Liquid Chromatography and Supercritical Fluid Chromatography. Four polysaccharide based chiral stationary phases namely amylose and cellulose tris(3, 5-dimethylphenylcarbamate), amylose tris((S)-α-phenylethylcarbamate) and cellulose tris(4-methylbenzoate) with four mobile phases consisted of either n-hexane/ethanol or propan-2-ol (80:20 v:v) or carbon dioxide/ethanol or propan-2-ol (80:20 v:v) mixtures were investigated under same operatory conditions (temperature and flow-rate). The elution strength, enantioselectivity and resolution were compared in the two methodologies. For these compounds, for most of the conditions, HPLC afforded shorter retention times and a higher resolution than SFC. HPLC appears particularly suitable for the separation of the compounds bearing two chiral centers. For instance compound 7 was baseline resolved on OD-H CSP under n-Hex/EtOH 80/20, with resolution values equal to 2.98, 1.55, 4.52, between the four stereoisomers in less than 17 min, whereas in SFC, this latter is not fully separated in 23 min under similar eluting conditions. After analytical screenings, the best conditions were transposed to semi-preparative scale. Copyright © 2018 Elsevier B.V. All rights reserved.

  12. A Phase of Liposomes with Entangled Tubular Vesicles

    Science.gov (United States)

    Chiruvolu, Shivkumar; Warriner, Heidi E.; Naranjo, Edward; Idziak, Stefan H. J.; Radler, Joachim O.; Plano, Robert J.; Zasadzinski, Joseph A.; Safinya, Cyrus R.

    1994-11-01

    An equilibrium phase belonging to the family of bilayer liposomes in ternary mixtures of dimyristoylphosphatidylcholine (DMPC), water, and geraniol (a biological alcohol derived from oil-soluble vitamins that acts as a cosurfactant) has been identified. Electron and optical microscopy reveal the phase, labeled Ltv, to be composed of highly entangled tubular vesicles. In situ x-ray diffraction confirms that the tubule walls are multilamellar with the lipids in the chain-melted state. Macroscopic observations show that the Ltv phase coexists with the well-known L_4 phase of spherical vesicles and a bulk L_α phase. However, the defining characteristic of the Ltv phase is the Weissenberg rod climbing effect under shear, which results from its polymer-like entangled microstructure.

  13. Correlation and Prediction of Phase Equilibria and Volumetric Behaviour of Hyperbaric Binary Fluids Corrélation et prédiction des équilibres de phases et du comportement volumétrique de fluides hyperbares binaires

    Directory of Open Access Journals (Sweden)

    Stamataki S. K.

    2006-11-01

    Full Text Available The capabilities of cubic Equations of State (EoS in the correlation and the prediction of phase equilibria at hyperbaric conditions is examined. PVT data of pure compounds as well as VLE and volumetric data of binary mixtures up to 2000 bar are used. Correlation and prediction results are presented with the translated and modified Peng-Robinson (t - mPR EoS and EoS/GE models. The performance of cubic EoS with a single interaction parameter (kij in describing VLE is remarkable considering the level of pressures involved. The same is valid for the PVT results including the relative liquid volumes of the C1/nC24 system. With typical errors of about 10% deviations in pressure of 100 - 200 bar are, of course, encountered which can be eliminated by the use of second interaction coefficient in the covolume combining rule. Predicted kij values obtained from generalized correlations developed from low pressure VLE data provide reasonable results for systems with hydrocarbons up to nC16 even at high pressures, but fail for higher asymmetric ones. Volume translation is essential for PVT predictions. The temperature independent translation of t - mPR and that of Jhaveri and Yougren give very satisfactory results. LCVM provides the best results of the EoS/GE models studied and gives very good predictions for rather symmetric systems which become poorer with asymmetric ones at very high pressures. La capacité des équations d'état (EoS cubiques pour corréler et prédire les équilibres de phases en conditions hyperbares est analysée. Les données PVT de corps purs ainsi que les données d'équilibres liquide-vapeur (VLE et volumétriques pour des mélanges binaires, jusqu'à 2000 bar sont utilisées. Les résultats des corrélations et des prédictions sont présentés pour l'équation de Peng-Robinson translatée et modifiée (t - mPR, ainsi que pour les modèles EoS/GE. Les performances des EoS cubiques avec un paramètre d'interaction unique (kij pour

  14. Gas phase synthesis of core-shell Fe@FeO{sub x} magnetic nanoparticles into fluids

    Energy Technology Data Exchange (ETDEWEB)

    Aktas, Sitki, E-mail: aksitki61@gmail.com; Thornton, Stuart C.; Binns, Chris [University of Leicester, Department of Physics and Astronomy (United Kingdom); Denby, Phil [Ensol As, Nesttun (Norway)

    2016-12-15

    Sorbitol, short chain molecules, have been used to stabilise of Fe@FeO{sub x} nanoparticles produced in the gas phase under the ultra-high vacuum (UHV) conditions. The sorbitol coated Fe@FeO{sub x} nanoparticles produced by our method have a narrow size distribution with a hydrodynamic diameter of 35 nm after NaOH is added to the solution. Magnetisation measurement shows that the magnetic nanoparticles are superparamagnetic at 100 K and demonstrate hysteresis at 5 K with an anisotropy constant of 5.31 × 10{sup 4} J/m{sup 3} (similar to bulk iron). Also, it is shown that sorbitol is only suitable for stabilising the Fe@FeO{sub x} suspensions, and it does not prevent further oxidation of the metallic Fe core. According to MRI measurement, the nanoparticles have a high transverse relaxation rate of 425 mM{sup −1} s{sup −1}.

  15. Structure of the ripple phase of phospholipid multibilayers

    International Nuclear Information System (INIS)

    Sengupta, Kheya; Raghunathan, V.A.; Katsaras, John

    2003-01-01

    We present electron density maps (EDMs) of the ripple phase formed by phosphorylcholine lipids such as dimyristoyl phosphatidylcholine (DMPC), palmitoyl-oleoyl phosphatidylcholine (POPC), dihexadecyl phosphatidylcholine, and dilauroyl phosphatidylcholine (DLPC). With the exception of DLPC, the rippled bilayers have a sawtooth shape in all the systems, with one arm being almost twice as long as the other. For DMPC and POPC bilayers, EDMs have been obtained at different temperatures at a fixed relative humidity, and the overall shape of the ripples and the ratio of the lengths of the two arms are found to be insensitive to temperature. EDMs of all the systems with saturated hydrocarbon chains suggest the existence of a mean chain tilt along the ripple wave vector. In the literature it is generally assumed that the asymmetry of the rippled bilayers (absence of a mirror plane normal to the ripple wave vector) arises from a sawtoothlike height profile. However, in the case of DLPC, the height profile is found to be almost symmetric and the asymmetry results mainly from different bilayer thicknesses in the two arms of the ripple. We also present EDMs of the metastable ripple phase of dipalmitoyl phosphatidylcholine, formed on cooling from the L α phase

  16. Determination of 18 beta-glycyrrhetinic acid in biological fluids from humans and rats by solid-phase extraction and high-performance liquid chromatography.

    Science.gov (United States)

    Hasler, F; Krapf, R; Brenneisen, R; Bourquin, D; Krähenbühl, S

    1993-10-22

    Methods have been developed and characterized allowing rapid isolation and quantification of 18 beta-glycyrrhetinic acid (GRA) in biological fluids from both humans and rats. Sample preparation includes extraction with urea-methanol for plasma samples, and solid-phase extraction (SPE) for urine and bile samples. Hydrolysis of GRA glucuronides in urine and bile was performed by treatment with beta-glucuronidase. MGRA, the 3-O-methyl derivative of GRA was synthesized as an internal standard resistant to hydrolysis. High-performance liquid chromatography (HPLC) was performed with an isocratic system using methanol-water-acetic acid (83:16.8:0.2, v/v/v) as solvent on a Lichrocart RP-18 column at 30 degrees C with ultraviolet detection. The methods allowed base line separation of GRA and MGRA from all biological fluids tested, with a detection limit of 0.15 mg/l. Validation of the methods included determination of recovery, accuracy and precision in plasma, bile and urine from humans and rats. The methods were further evaluated by investigating the pharmacokinetics of GRA in normal rats and in rats with a bile fistula. Following an intravenous dose of 10 mg/kg, the plasma concentration-time curve of GRA could be fitted to a one compartment model both in control and bile fistula rats. The elimination half life averaged 15.0 +/- 2.2 versus 16.8 +/- 2.4 min in control and bile fistula rats (difference not significant). Within 90 min following administration of GRA, urinary elimination of GRA and GRA glucuronides was less than 1% in both groups whereas biliary elimination averaged 51.3 +/- 3.1%. The results show that the methods developed allow pharmacokinetic studies of GRA in humans and rats.

  17. Dissolvable layered double hydroxide as an efficient nanosorbent for centrifugeless air-agitated dispersive solid-phase extraction of potentially toxic metal ions from bio-fluid samples

    Energy Technology Data Exchange (ETDEWEB)

    Rajabi, Maryam, E-mail: mrajabi@semnan.ac.ir; Arghavani-Beydokhti, Somayeh; Barfi, Behruz; Asghari, Alireza

    2017-03-08

    In the present work, a novel nanosorbent namely layered double hydroxides with 4-amino-5-hydroxyl-2,7-naphthalendisulfonic acid monosodium salt interlayer anion (Mg-Al-AHNDA-LDH) was synthesized and applied as a dissolvable nanosorbent in a centrifugeless ultrasound-enhanced air-agitated dispersive solid-phase extraction (USE-AA-D-SPE) method. This method was used for the separation and preconcentration of some metal ions including Cd{sup 2+}, Cr{sup 6+}, Pb{sup 2+}, Co{sup 2+}, and Ni{sup 2+} prior to their determination using the micro-sampling flame atomic absorption spectrometry (MS-FAAS) technique. The most interesting aspect of this nanosorbent is its immediate dissolvability at pH values lower than 4. This capability drastically eliminates the elution step, leading to a great improvement in the extraction efficiency and a decrease in the extraction time. Also in this method, the use of a syringe nanofilter eliminates the need for the centrifugation step, which is time-consuming and essentially causes the analysis to be off-line. Several effective parameters governing the extraction efficiency including the sample solution pH, amount of nanosorbent, eluent condition, number of air-agitation cycles, and sonication time were investigated and optimized. Under the optimized conditions, the good linear dynamic ranges of 2–70, 6–360, 7–725, 7–370, and 8–450 ng mL{sup −1} for the Cd{sup 2+}, Cr{sup 6+}, Pb{sup 2+}, Co{sup 2+}and Ni{sup 2+} ions, respectively, with the correlation of determinations (R{sup 2}s) higher than 0.997 were obtained. The limits of detection (LODs) were found to be 0.6, 1.7, 2.0, 2.1, and 2.4 for the Cd{sup 2+}, Cr{sup 6+}, Pb{sup 2+}, Co{sup 2+}, and Ni{sup 2+} ions, respectively. The intra-day and inter-day precisions (percent relative standard deviations (%RSDs) (n = 5)) were below 7.8%. The proposed method was also successfully applied for the extraction and determination of the target ions in different biological fluid

  18. Dissolvable layered double hydroxide as an efficient nanosorbent for centrifugeless air-agitated dispersive solid-phase extraction of potentially toxic metal ions from bio-fluid samples

    International Nuclear Information System (INIS)

    Rajabi, Maryam; Arghavani-Beydokhti, Somayeh; Barfi, Behruz; Asghari, Alireza

    2017-01-01

    In the present work, a novel nanosorbent namely layered double hydroxides with 4-amino-5-hydroxyl-2,7-naphthalendisulfonic acid monosodium salt interlayer anion (Mg-Al-AHNDA-LDH) was synthesized and applied as a dissolvable nanosorbent in a centrifugeless ultrasound-enhanced air-agitated dispersive solid-phase extraction (USE-AA-D-SPE) method. This method was used for the separation and preconcentration of some metal ions including Cd 2+ , Cr 6+ , Pb 2+ , Co 2+ , and Ni 2+ prior to their determination using the micro-sampling flame atomic absorption spectrometry (MS-FAAS) technique. The most interesting aspect of this nanosorbent is its immediate dissolvability at pH values lower than 4. This capability drastically eliminates the elution step, leading to a great improvement in the extraction efficiency and a decrease in the extraction time. Also in this method, the use of a syringe nanofilter eliminates the need for the centrifugation step, which is time-consuming and essentially causes the analysis to be off-line. Several effective parameters governing the extraction efficiency including the sample solution pH, amount of nanosorbent, eluent condition, number of air-agitation cycles, and sonication time were investigated and optimized. Under the optimized conditions, the good linear dynamic ranges of 2–70, 6–360, 7–725, 7–370, and 8–450 ng mL −1 for the Cd 2+ , Cr 6+ , Pb 2+ , Co 2+ and Ni 2+ ions, respectively, with the correlation of determinations (R 2 s) higher than 0.997 were obtained. The limits of detection (LODs) were found to be 0.6, 1.7, 2.0, 2.1, and 2.4 for the Cd 2+ , Cr 6+ , Pb 2+ , Co 2+ , and Ni 2+ ions, respectively. The intra-day and inter-day precisions (percent relative standard deviations (%RSDs) (n = 5)) were below 7.8%. The proposed method was also successfully applied for the extraction and determination of the target ions in different biological fluid and tap water samples. - Highlights: • A novel centrifugeless dispersive

  19. A rapid MCM-41 dispersive micro-solid phase extraction coupled with LC/MS/MS for quantification of ketoconazole and voriconazole in biological fluids.

    Science.gov (United States)

    Yahaya, Noorfatimah; Sanagi, Mohd Marsin; Abd Aziz, Noorizan; Wan Ibrahim, Wan Aini; Nur, Hadi; Loh, Saw Hong; Kamaruzaman, Sazlinda

    2017-02-01

    A rapid dispersive micro-solid phase extraction (D-μ-SPE) combined with LC/MS/MS method was developed and validated for the determination of ketoconazole and voriconazole in human urine and plasma samples. Synthesized mesoporous silica MCM-41 was used as sorbent in d-μ-SPE of the azole compounds from biological fluids. Important D-μ-SPE parameters, namely type desorption solvent, extraction time, sample pH, salt addition, desorption time, amount of sorbent and sample volume were optimized. Liquid chromatographic separations were carried out on a Zorbax SB-C 18 column (2.1 × 100 mm, 3.5 μm), using a mobile phase of acetonitrile-0.05% formic acid in 5 mm ammonium acetate buffer (70:30, v/v). A triple quadrupole mass spectrometer with positive ionization mode was used for the determination of target analytes. Under the optimized conditions, the calibration curves showed good linearity in the range of 0.1-10,000 μg/L with satisfactory limit of detection (≤0.06 μg/L) and limit of quantitation (≤0.3 μg/L). The proposed method also showed acceptable intra- and inter-day precisions for ketoconazole and voriconazole from urine and human plasma with RSD ≤16.5% and good relative recoveries in the range 84.3-114.8%. The MCM-41-D-μ-SPE method proved to be rapid and simple and requires a small volume of organic solvent (200 μL); thus it is advantageous for routine drug analysis. Copyright © 2016 John Wiley & Sons, Ltd.

  20. SPAMM, cine phase contrast imaging and fast spin-echo T2-weighted imaging in the study of intracranial cerebrospinal fluid (CSF) flow

    International Nuclear Information System (INIS)

    Connor, S.E.J.; O'Gorman, R.; Summers, P.; Simmons, A.; Moore, E.M.; Chandler, C.; Jarosz, J.M.

    2001-01-01

    AIM: To compare the qualitative assessment of cerebrospinal fluid (CSF) flow using a SPAMM (spatial modulation of magnetization) technique with cine phase contrast images (cine PC) and fast spin echo (FSE) T2-weighted images. MATERIALS AND METHODS: SPAMM, PC and T2-weighted sequences were performed on 22 occasions in 19 patients. Eleven of the studies were performed following a neuroendoscopic third ventriculostomy (NTV), and in these cases, the success of the NTV was determined by clinical follow-up. Two observers used consensus to grade the presence of CSF flow at nine different sites for each study. RESULTS: At 14 of the 178 matched sites, which could be assessed by both SPAMM and cine PC, SPAMM CSF flow grade was higher than that of cine PC. At a further 14/178 matched sites, the cine PC grade was higher than that of SPAMM. There was definite CSF flow at 113/182 (62%) of all the cine PC sites assessed, and 110/181 (61%) of all SPAMM sites assessed whilst 108/198 (54%) of FSE T2-weighted image sites demonstrated flow voids. Cine PC grades were higher than SPAMM at the cerebral aqueduct (P < 0.05, Wilcoxon sign rank test). Definite CSF flow within the anterior third ventricle was present in 4/5 (SPAMM) and 3/5 (cine PC) successful NTVs, 0/2 (SPAMM and cine PC) unsuccessful NTVs and 1/10 (SPAMM and cine PC) patients without NTV. CONCLUSION: SPAMM provides a comparable assessment of intracranial CSF flow to that of cine phase contrast imaging at all CSF sites except the cerebral aqueduct. Connor, S.E.J. et al. (2001)

  1. In vivo hemodynamic analysis of intracranial aneurysms obtained by magnetic resonance fluid dynamics (MRFD) based on time-resolved three-dimensional phase-contrast MRI

    International Nuclear Information System (INIS)

    Isoda, Haruo; Takeda, Hiroyasu; Yamashita, Shuhei; Takehara, Yasuo; Sakahara, Harumi; Ohkura, Yasuhide; Kosugi, Takashi; Hirano, Masaya; Hiramatsu, Hisaya; Namba, Hiroki; Alley, Marcus T.; Bammer, Roland; Pelc, Norbert J.

    2010-01-01

    Hemodynamics is thought to play a very important role in the initiation, growth, and rupture of intracranial aneurysms. The purpose of our study was to perform in vivo hemodynamic analysis of unruptured intracranial aneurysms of magnetic resonance fluid dynamics using time-resolved three-dimensional phase-contrast MRI (4D-Flow) at 1.5 T and to analyze relationships between hemodynamics and wall shear stress (WSS) and oscillatory shear index (OSI). This study included nine subjects with 14 unruptured aneurysms. 4D-Flow was performed by a 1.5-T magnetic resonance scanner with a head coil. We calculated in vivo streamlines, WSS, and OSI of intracranial aneurysms based on 4D-Flow with our software. We evaluated the number of spiral flows in the aneurysms and compared the differences in WSS or OSI between the vessel and aneurysm and between whole aneurysm and the apex of the spiral flow. 3D streamlines, WSS, and OSI distribution maps in arbitrary direction during the cardiac phase were obtained for all intracranial aneurysms. Twelve aneurysms had one spiral flow each, and two aneurysms had two spiral flows each. The WSS was lower and the OSI was higher in the aneurysm compared to the vessel. The apex of the spiral flow had a lower WSS and higher OSI relative to the whole aneurysm. Each intracranial aneurysm in this study had at least one spiral flow. The WSS was lower and OSI was higher at the apex of the spiral flow than the whole aneurysmal wall. (orig.)

  2. In vivo hemodynamic analysis of intracranial aneurysms obtained by magnetic resonance fluid dynamics (MRFD) based on time-resolved three-dimensional phase-contrast MRI.

    Science.gov (United States)

    Isoda, Haruo; Ohkura, Yasuhide; Kosugi, Takashi; Hirano, Masaya; Takeda, Hiroyasu; Hiramatsu, Hisaya; Yamashita, Shuhei; Takehara, Yasuo; Alley, Marcus T; Bammer, Roland; Pelc, Norbert J; Namba, Hiroki; Sakahara, Harumi

    2010-10-01

    Hemodynamics is thought to play a very important role in the initiation, growth, and rupture of intracranial aneurysms. The purpose of our study was to perform in vivo hemodynamic analysis of unruptured intracranial aneurysms of magnetic resonance fluid dynamics using time-resolved three-dimensional phase-contrast MRI (4D-Flow) at 1.5 T and to analyze relationships between hemodynamics and wall shear stress (WSS) and oscillatory shear index (OSI). This study included nine subjects with 14 unruptured aneurysms. 4D-Flow was performed by a 1.5-T magnetic resonance scanner with a head coil. We calculated in vivo streamlines, WSS, and OSI of intracranial aneurysms based on 4D-Flow with our software. We evaluated the number of spiral flows in the aneurysms and compared the differences in WSS or OSI between the vessel and aneurysm and between whole aneurysm and the apex of the spiral flow. 3D streamlines, WSS, and OSI distribution maps in arbitrary direction during the cardiac phase were obtained for all intracranial aneurysms. Twelve aneurysms had one spiral flow each, and two aneurysms had two spiral flows each. The WSS was lower and the OSI was higher in the aneurysm compared to the vessel. The apex of the spiral flow had a lower WSS and higher OSI relative to the whole aneurysm. Each intracranial aneurysm in this study had at least one spiral flow. The WSS was lower and OSI was higher at the apex of the spiral flow than the whole aneurysmal wall.

  3. Analysis of the two-fluid model and the drift-flux model for numerical calculation of two-phase flow

    Energy Technology Data Exchange (ETDEWEB)

    Munkejord, Svend Tollak

    2006-05-11

    This thesis analyses models for two-phase flows and methods for the numerical resolution of these models. It is therefore one contribution to the development of reliable design tools for multiphase applications. Such tools are needed and expected by engineers in a range of fields, including in the oil and gas industry. The approximate Riemann solver of Roe has been studied. Roe schemes for three different two-phase flow models have been implemented in the framework of a standard numerical algorithm for the solution of hyperbolic conservation laws. The schemes have been analysed by calculation of benchmark tests from the literature, and by comparison with each other. A Roe scheme for the four-equation one-pressure two-fluid model has been implemented, and a second-order extension based on wave decomposition and flux-difference splitting was shown to work well and to give improved results compared to the first-order scheme. The convergence properties of the scheme were tested on smooth and discontinuous solutions. A Roe scheme has been proposed for a five-equation two-pressure two-fluid model with pressure relaxation. The use of analogous numerical methods for the five-equation and four-equation models allowed for a direct comparison of a method with and without pressure relaxation. Numerical experiments demonstrated that the two approaches converged to the same results, but that the five-equation pressure-relaxation method was significantly more dissipative, particularly for contact discontinuities. Furthermore, even though the five-equation model with instantaneous pressure relaxation has real eigenvalues, the calculations showed that it produced oscillations for cases where the four-equation model had complex eigenvalues. A Roe scheme has been constructed for the drift-flux model with general closure laws. For the case of the Zuber-Findlay slip law describing bubbly flows, the Roe matrix is completely analytical. Hence the present Roe scheme is more efficient than

  4. An experimental validation of the influence of flow profiles and stratified two-phase flow to Lorentz force velocimetry for weakly conducting fluids

    Science.gov (United States)

    Wiederhold, Andreas; Ebert, Reschad; Resagk, Christian; Research Training Group: "Lorentz Force Velocimetry; Lorentz Force Eddy Current Testing" Team

    2016-11-01

    We report about the feasibility of Lorentz force velocimetry (LFV) for various flow profiles. LFV is a contactless non-invasive technique to measure flow velocity and has been developed in the last years in our institute. This method is advantageous if the fluid is hot, aggressive or opaque like glass melts or liquid metal flows. The conducted experiments shall prove an increased versatility for industrial applications of this method. For the force measurement we use an electromagnetic force compensation balance. As electrolyte salty water is used with an electrical conductivity in the range of 0.035 which corresponds to tap water up to 20 Sm-1. Because the conductivity is six orders less than that of liquid metals, here the challenging bottleneck is the resolution of the measurement system. The results show only a slight influence in the force signal at symmetric and strongly asymmetric flow profiles. Furthermore we report about the application of LFV to stratified two-phase flows. We show that it is possible to detect interface instabilities, which is important for the dimensioning of liquid metal batteries. Deutsche Forschungsgemeinschaft DFG.

  5. Cerebrospinal fluid pulsation amplitude and its quantitative relationship to cerebral blood flow pulsations: a phase-contrast MR flow imaging study

    International Nuclear Information System (INIS)

    Bhadelia, R.A.; Bogdan, A.R.; Kaplan, R.F.; Wolpert, S.M.

    1997-01-01

    Our purpose in this investigation was to explain the heterogeneity in the cerebrospinal fluid (CSF) flow pulsation amplitudes. To this end, we determined the contributions of the cerebral arterial and jugular venous flow pulsations to the amplitude of the CSF pulsation. We examined 21 healthy subjects by cine phase-contrast MRI at the C2-3 disc level to demonstrate the CSF and vascular flows as waveforms. Multiple regression analysis was performed to calculate the contributions of (a) the arterial and venous waveform amplitudes and (b) the delay between the maximum systolic slopes of the arterial and venous waveforms (AV delay), in order to predict the amplitude of the CSF waveform. The contribution of the arterial waveform amplitude was positive (r = 0.61; p 0.003) to the CSF waveform amplitude and that of the venous waveform amplitude was negative (r = -0.50; p = 0.006). Both in combination accounted for 56 % of the variance in predicting the CSF waveform amplitude (p < 0.0006). The contribution of AV delay was not significant. The results show that the variance in the CSF flow pulsation amplitudes can be explained by concurrent evaluation of the CSF and vascular flows. Improvement in the techniques, and controlled experiments, may allow use of CSF flow pulsation amplitudes for clinical applications in the non-invasive assessment of intracranial dynamics by MRI. (orig.). With 3 figs., 2 tabs

  6. [Application of off-line two dimensional reversed-phase liquid chromatography/supercritical fluid chromatography to the separation of the seeds of Trichosanthes kirilowii Maxim].

    Science.gov (United States)

    Yuan, Yun; Xin, Huaxia; Peng, Ziyue; Fu, Qing; Jin, Yu

    2017-07-08

    An off-line two dimensional reversed-phase liquid chromatography/supercritical fluid chromatography (2D RPLC/SFC) method was developed for the separation of the seeds of Trichosanthes kirilowii Maxim . ( T. kirilowii .). In the experiment, RPLC was used in the first dimension to analyze the samples. And 12 fractions (F 1 -F 12 ) were obtained according to the chromatographic peak collection mode, the fractions were re-analyzed in both RPLC and SFC modes. The results clearly showed that this 2D method had good orthogonality. The SFC was used as the second dimension. Ethanol- n -hexane (3:7, v/v) was used as a modifier in SFC. The modifier could provide appropriate elution power. When the sample load increased, it could also ensure the solubility of samples. The 2D RPLC/SFC method had obvious advantages for separating the compounds with similar properties, enriching and purifying the trace components. Finally, 150 peaks could be detected. The off-line 2D RPLC/SFC method will be further enlarged to a preparative level for preparation of compounds. The method can provide a practical reference for the purification of chemical constituents and material basis research of the seeds of T. kirilowii . in the future.

  7. A novel application of Recursive Equation Method for determining thermodynamic properties of single phase fluids from density and speed-of-sound measurements

    International Nuclear Information System (INIS)

    Lago, S.; Giuliano Albo, P.A.

    2013-01-01

    Highlights: ► A novel method for calculating the isobaric specific heat capacity is presented. ► Heat capacity (C p ) was determined only by speed-of-sound and density measurements. ► (C p ) temperature dependence has been related to speed-of-sound by a new expression. ► Heat capacity for water, nonane, undecane, and rapeseed oil methyl ester are obtained. -- Abstract: The determination of thermal quantities from mechanical properties is still a challenge in the thermodynamic field. In this work, the authors suggest a preliminary numerical calculation which allows to determine the constant pressure specific heat capacity, starting from density and speed-of-sound experimental values, as input data. This method is a variant of the well characterized Recursive Equation Method (REM) [1] and permits to develop empirical equations of state for single phase fluids. In particular, the isobaric specific heat capacity has been obtained, in a wide range of temperatures and pressures, for pure water, n-nonane, n-undecane, and rapeseed oil methyl ester. The results have been compared with those available in the literature, when it was possible. Moreover, the typical uncertainty of heat capacity has been estimated to be in the order of 1.5%; however it has been shown that it can be improved when proper distributions of the experimental points are available

  8. Rapid and Green Separation of Mono- and Diesters of Monochloropropanediols by Ultrahigh Performance Supercritical Fluid Chromatography-Mass Spectrometry Using Neat Carbon Dioxide as a Mobile Phase.

    Science.gov (United States)

    Jumaah, Firas; Jędrkiewicz, Renata; Gromadzka, Justyna; Namieśnik, Jacek; Essén, Sofia; Turner, Charlotta; Sandahl, Margareta

    2017-09-20

    This study demonstrates the effect of column selectivity and density of supercritical carbon dioxide (SC-CO 2 ) on the separation of monochloropropanediol (MCPD) esters, known as food toxicants, using SC-CO 2 without addition of cosolvent in ultrahigh performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS). This study shows that over 20 2-monochloropropanediol (2-MCPD) and 3-monochloropropanediol (3-MCPD) mono- and diesters are separated on a 2-picolylamine column in less than 12 min. The presence and position of a hydroxyl group in the structure, the number of unsaturated bonds, and the acyl chain length play a significant role in the separation of MCPD esters. The flow rate, backpressure, and column oven temperature, which affect the density of the mobile phase, were shown to have a substantial impact on retention, efficiency, and selectivity. The developed method was successfully applied for the determination of MCPD esters in refined oils and showed a close to excellent green analysis score using the Analytical Eco-Scale.

  9. Relativistic thermodynamics of fluids

    International Nuclear Information System (INIS)

    Souriau, J.-M.

    1977-05-01

    The relativistic covariant definition of a statistical equilibrium, applied to a perfect gas, involves a 'temperature four-vector', whose direction is the mean velocity of the fluid, and whose length is the reciprocal temperature. The hypothesis of this 'temperature four-vector' being a relevant variable for the description of the dissipative motions of a simple fluid is discussed. The kinematics is defined by using a vector field and measuring the number of molecules. Such a dissipative fluid is subject to motions involving null entropy generation; the 'temperature four-vector' is then a Killing vector; the equations of motion can be completely integrated. Perfect fluids can be studied by this way and the classical results of Lichnerowicz are obtained. In weakly dissipative motions two viscosity coefficient appear together with the heat conductibility coefficient. Two other coefficients perharps measurable on real fluids. Phase transitions and shock waves are described with using the model [fr

  10. Thermodynamics of Fluid Polyamorphism

    Directory of Open Access Journals (Sweden)

    Mikhail A. Anisimov

    2018-01-01

    Full Text Available Fluid polyamorphism is the existence of different condensed amorphous states in a single-component fluid. It is either found or predicted, usually at extreme conditions, for a broad group of very different substances, including helium, carbon, silicon, phosphorous, sulfur, tellurium, cerium, hydrogen, and tin tetraiodide. This phenomenon is also hypothesized for metastable and deeply supercooled water, presumably located a few degrees below the experimental limit of homogeneous ice formation. We present a generic phenomenological approach to describe polyamorphism in a single-component fluid, which is completely independent of the molecular origin of the phenomenon. We show that fluid polyamorphism may occur either in the presence or in the absence of fluid phase separation depending on the symmetry of the order parameter. In the latter case, it is associated with a second-order transition, such as in liquid helium or liquid sulfur. To specify the phenomenology, we consider a fluid with thermodynamic equilibrium between two distinct interconvertible states or molecular structures. A fundamental signature of this concept is the identification of the equilibrium fraction of molecules involved in each of these alternative states. However, the existence of the alternative structures may result in polyamorphic fluid phase separation only if mixing of these structures is not ideal. The two-state thermodynamics unifies all the debated scenarios of fluid polyamorphism in different areas of condensed-matter physics, with or without phase separation, and even goes beyond the phenomenon of polyamorphism by generically describing the anomalous properties of fluids exhibiting interconversion of alternative molecular states.

  11. Supercritical fluid chromatography

    Science.gov (United States)

    Vigdergauz, M. S.; Lobachev, A. L.; Lobacheva, I. V.; Platonov, I. A.

    1992-03-01

    The characteristic features of supercritical fluid chromatography (SCFC) are examined and there is a brief historical note concerning the development of the method. Information concerning the use of supercritical fluid chromatography in the analysis of objects of different nature is presented in the form of a table. The roles of the mobile and stationary phases in the separation process and the characteristic features of the apparatus and of the use of the method in physicochemical research are discussed. The bibliography includes 364 references.

  12. Heat transfer study of a two-phase refrigerant with liquid-solid phase change inside a smooth plates heat exchanger; Etude des transferts de chaleur d'un fluide frigoporteur diphasique a changement de phase liquide-solide dans un echangeur a plaques lisses

    Energy Technology Data Exchange (ETDEWEB)

    Demasles, H.

    2002-05-15

    The purpose of the work is to study two-phase mixture heat exchange composed of water particles suspended in silicone oil circulating in a closed loop. Water, contained in polymer porous matrix, is freezing by successive passages in plane plate heat exchanger. Thermo-hydraulic literature data analysis about these fluids in exchangers shows important blanks in exchange coefficient and pressure drop forecast methods and in experimental data. Experimental results, issued of global energy balance on a test section specifically conceived and made for this study, show doping effect on exchange coefficient. Before phase change, micro-convective effects of rotating particles improve exchange coefficient of 2,3 factor. Supplementary enhancement included between 2 and 16 appeared during phase change. Trial measured discrepancy are certainly induced by bed layer formation due to low flow speed. At the end of particle freezing, when latent heat is not involved anymore in exchange enhancement, important heat transfer reduction is observed. This is attributed to the cooling suspension rheological evolution and the change of flow particle distribution. Modelling results corroborate heat exchange improvement due to phase change: particles act as sources when discharging there latent heat. They stop fluid temperature dropping and enable to keep a high wall temperature gradient. A deepened suspension rheological study is necessary for a better understanding of observed phenomenon, nevertheless these first results show already an important energetic profit brings by particles in range temperature of 0 and -6 deg C. (author)

  13. Fluid Mechanics.

    Science.gov (United States)

    Drazin, Philip

    1987-01-01

    Outlines the contents of Volume II of "Principia" by Sir Isaac Newton. Reviews the contributions of subsequent scientists to the physics of fluid dynamics. Discusses the treatment of fluid mechanics in physics curricula. Highlights a few of the problems of modern research in fluid dynamics. Shows that problems still remain. (CW)

  14. Synchrotron x-ray spectroscopy of EuHN O3 aqueous solutions at high temperatures and pressures and Nb-bearing silicate melt phases coexisting with hydrothermal fluids using a modified hydrothermal diamond anvil cell and rail assembly

    Science.gov (United States)

    Mayanovic, Robert A.; Anderson, Alan J.; Bassett, William A.; Chou, I.-Ming

    2007-01-01

    A modified hydrothermal diamond anvil cell (HDAC) rail assembly has been constructed for making synchrotron x-ray absorption spectroscopy, x-ray fluorescence, and x-ray mapping measurements on fluids or solid phases in contact with hydrothermal fluids up to ???900??C and 700 MPa. The diamond anvils of the HDAC are modified by laser milling grooves or holes, for the reduction of attenuation of incident and fluorescent x rays and sample cavities. The modified HDAC rail assembly has flexibility in design for measurement of light elements at low concentrations or heavy elements at trace levels in the sample and the capability to probe minute individual phases of a multiphase fluid-based system using focused x-ray microbeam. The supporting rail allows for uniform translation of the HDAC, rotation and tilt stages, and a focusing mirror, which is used to illuminate the sample for visual observation using a microscope, relative to the direction of the incident x-ray beam. A structure study of Eu(III) aqua ion behavior in high-temperature aqueous solutions and a study of Nb partitioning and coordination in a silicate melt in contact with a hydrothermal fluid are described as applications utilizing the modified HDAC rail assembly. ?? 2007 American Institute of Physics.

  15. Hazards of organic working fluids

    International Nuclear Information System (INIS)

    Silberstein, S.

    1977-08-01

    We present several brief reviews on working fluids proposed for use in organic Rankine and bi-phase bottoming cycles. There are several general problems with many organic working fluids: flammability, toxicity, and a tendency to leak through seals. Besides, two of the proposed working fluids are to be used at temperatures above the manufacturer's maximum recommended temperature, and one is to be used in a way different from its customary usage. It may, in some cases, be more profitable to first seek alternative working fluids before committing large amounts of time and money to research projects on unsafe working fluids

  16. Fluids engineering

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Fluids engineering has played an important role in many applications, from ancient flood control to the design of high-speed compact turbomachinery. New applications of fluids engineering, such as in high-technology materials processing, biotechnology, and advanced combustion systems, have kept up unwaining interest in the subject. More accurate and sophisticated computational and measurement techniques are also constantly being developed and refined. On a more fundamental level, nonlinear dynamics and chaotic behavior of fluid flow are no longer an intellectual curiosity and fluid engineers are increasingly interested in finding practical applications for these emerging sciences. Applications of fluid technology to new areas, as well as the need to improve the design and to enhance the flexibility and reliability of flow-related machines and devices will continue to spur interest in fluids engineering. The objectives of the present seminar were: to exchange current information on arts, science, and technology of fluids engineering; to promote scientific cooperation between the fluids engineering communities of both nations, and to provide an opportunity for the participants and their colleagues to explore possible joint research programs in topics of high priority and mutual interest to both countries. The Seminar provided an excellent forum for reviewing the current state and future needs of fluids engineering for the two nations. With the Seminar ear-marking the first formal scientific exchange between Korea and the United States in the area of fluids engineering, the scope was deliberately left broad and general

  17. Dissolvable layered double hydroxide as an efficient nanosorbent for centrifugeless air-agitated dispersive solid-phase extraction of potentially toxic metal ions from bio-fluid samples.

    Science.gov (United States)

    Rajabi, Maryam; Arghavani-Beydokhti, Somayeh; Barfi, Behruz; Asghari, Alireza

    2017-03-08

    In the present work, a novel nanosorbent namely layered double hydroxides with 4-amino-5-hydroxyl-2,7-naphthalendisulfonic acid monosodium salt interlayer anion (Mg-Al-AHNDA-LDH) was synthesized and applied as a dissolvable nanosorbent in a centrifugeless ultrasound-enhanced air-agitated dispersive solid-phase extraction (USE-AA-D-SPE) method. This method was used for the separation and preconcentration of some metal ions including Cd 2+ , Cr 6+ , Pb 2+ , Co 2+ , and Ni 2+ prior to their determination using the micro-sampling flame atomic absorption spectrometry (MS-FAAS) technique. The most interesting aspect of this nanosorbent is its immediate dissolvability at pH values lower than 4. This capability drastically eliminates the elution step, leading to a great improvement in the extraction efficiency and a decrease in the extraction time. Also in this method, the use of a syringe nanofilter eliminates the need for the centrifugation step, which is time-consuming and essentially causes the analysis to be off-line. Several effective parameters governing the extraction efficiency including the sample solution pH, amount of nanosorbent, eluent condition, number of air-agitation cycles, and sonication time were investigated and optimized. Under the optimized conditions, the good linear dynamic ranges of 2-70, 6-360, 7-725, 7-370, and 8-450 ng mL -1 for the Cd 2+ , Cr 6+ , Pb 2+ , Co 2+ and Ni 2+ ions, respectively, with the correlation of determinations (R 2 s) higher than 0.997 were obtained. The limits of detection (LODs) were found to be 0.6, 1.7, 2.0, 2.1, and 2.4 for the Cd 2+ , Cr 6+ , Pb 2+ , Co 2+ , and Ni 2+ ions, respectively. The intra-day and inter-day precisions (percent relative standard deviations (%RSDs) (n = 5)) were below 7.8%. The proposed method was also successfully applied for the extraction and determination of the target ions in different biological fluid and tap water samples. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Buffer fluid

    Energy Technology Data Exchange (ETDEWEB)

    Mirzadzhanzade, A Kh; Dedusanko, G Ya; Dinaburg, L S; Markov, Yu M; Rasizade, Ya N; Rozov, V N; Sherstnev, N M

    1979-08-30

    A drilling fluid is suggested for separating the drilling and plugging fluids which contains as the base increased solution of polyacrylamide and additive. In order to increase the viscoelastic properties of the liquid with simultaneous decrease in the periods of its fabrication, the solution contains as an additive dry bentonite clay. In cases of the use of a buffer fluid under conditions of negative temperatures, it is necessary to add to it table salt or ethylene glycol.

  19. Schroedinger fluid

    International Nuclear Information System (INIS)

    Kan, K.K.

    1983-01-01

    The relationship of nuclear internal flow and collective inertia, the difference of this flow from that of a classical fluid, and the approach of this flow to rigid flow in independent-particle model rotation are elucidated by reviewing the theory of Schroedinger fluid and its implications for collective vibration and rotation. (author)

  20. Clusters in simple fluids

    International Nuclear Information System (INIS)

    Sator, N.

    2003-01-01

    This article concerns the correspondence between thermodynamics and the morphology of simple fluids in terms of clusters. Definitions of clusters providing a geometric interpretation of the liquid-gas phase transition are reviewed with an eye to establishing their physical relevance. The author emphasizes their main features and basic hypotheses, and shows how these definitions lead to a recent approach based on self-bound clusters. Although theoretical, this tutorial review is also addressed to readers interested in experimental aspects of clustering in simple fluids

  1. Two-phase characteristics of the feeding fluid of Cerro Prieto IV wells (Mexico) obtained by gas equilibrium; Caracteristicas bifasicas del fluido de alimentacion de pozos de Cerro Prieto IV (Mexico), obtenidas por equilibrio gaseoso

    Energy Technology Data Exchange (ETDEWEB)

    Barragan-Reyes, Rosa Maria; Arellano-Gomez, Victor Manuel; Portugal-Marin, Enrique [Instituto de Investigaciones Electricas (Mexico); De Leon-Vivar, Jesus [Comision Federal de Electricidad, Residencia General de Cerro Prieto, B.C (Mexico)

    2008-10-15

    The gas composition of fluids produced by CP IV geothermal wells from the Cerro Prieto field was studied in order to identify different types of fluids entering the wells by estimating their temperature and excess steam. A method based on the Fischer Tropsch reaction and H2S equilibrium with pyrite-pyrrhotite as mineral buffer (FTHSH3) was used. The results for the reservoir natural state indicated the presence of fluids with heterogeneous reservoir temperature (between 275 and 310 degrees Celsius) and excess steam values, which were found from negative (boiled liquid that has lost steam when flowing to the well) to one (steam phase with zero liquid saturation). The study for individual wells in which boiling processes were identified, showed that through time, the feeding fluids consist of a two-phase mixture with different liquid/steam proportions. Also, the results suggested that a steam phase could occur at CP IV which is added to the feeding fluid, depending on the operation conditions of the wells. The origin of this steam could be the boiling of the deeper liquid due to a pressure drop. [Spanish] Se estudio la composicion gaseosa de los fluidos producidos por pozos geotermicos del sector CP IV del campo de Cerro Prieto para tratar de distinguir aportes de fluidos diferentes mediante la estimacion de su temperatura de yacimiento y del exceso de vapor. Se utilizo un metodo de equilibrio gaseoso basado en la reaccion de Fischer Tropsch y el equilibrio combinado pirita-pirrotita (FT-HSH3). Los resultados obtenidos indican que en el estado inicial del yacimiento existen fluidos que muestran heterogeneidad en los valores de temperatura de yacimiento (entre 275 y 310 grados Celsius), asi como en el exceso de vapor con valores desde negativos (liquido que despues de ebullir ha perdido vapor en su trayecto hacia el pozo) hasta uno (vapor con cero saturacion de liquido). El estudio individual de los pozos con fenomenos de ebullicion muestra que a traves del tiempo

  2. Fluid dynamics

    CERN Document Server

    Bernard, Peter S

    2015-01-01

    This book presents a focused, readable account of the principal physical and mathematical ideas at the heart of fluid dynamics. Graduate students in engineering, applied math, and physics who are taking their first graduate course in fluids will find this book invaluable in providing the background in physics and mathematics necessary to pursue advanced study. The book includes a detailed derivation of the Navier-Stokes and energy equations, followed by many examples of their use in studying the dynamics of fluid flows. Modern tensor analysis is used to simplify the mathematical derivations, thus allowing a clearer view of the physics. Peter Bernard also covers the motivation behind many fundamental concepts such as Bernoulli's equation and the stream function. Many exercises are designed with a view toward using MATLAB or its equivalent to simplify and extend the analysis of fluid motion including developing flow simulations based on techniques described in the book.

  3. Different Diversity and Distribution of Archaeal Community in the Aqueous and Oil Phases of Production Fluid From High-Temperature Petroleum Reservoirs

    Directory of Open Access Journals (Sweden)

    Bo Liang

    2018-04-01

    Full Text Available To get a better knowledge on how archaeal communities differ between the oil and aqueous phases and whether environmental factors promote substantial differences on microbial distributions among production wells, we analyzed archaeal communities in oil and aqueous phases from four high-temperature petroleum reservoirs (55–65°C by using 16S rRNA gene based 454 pyrosequencing. Obvious dissimilarity of the archaeal composition between aqueous and oil phases in each independent production wells was observed, especially in production wells with higher water cut, and diversity in the oil phase was much higher than that in the corresponding aqueous phase. Statistical analysis further showed that archaeal communities in oil phases from different petroleum reservoirs tended to be more similar, but those in aqueous phases were the opposite. In the high-temperature ecosystems, temperature as an environmental factor could have significantly affected archaeal distribution, and archaeal diversity raised with the increase of temperature (p < 0.05. Our results suggest that to get a comprehensive understanding of petroleum reservoirs microbial information both in aqueous and oil phases should be taken into consideration. The microscopic habitats of oil phase, technically the dispersed minuscule water droplets in the oil could be a better habitat that containing the indigenous microorganisms.

  4. Ecotoxicological testing of performance fluids

    International Nuclear Information System (INIS)

    Kallqvist, T.

    1990-05-01

    The report deals with a project comprising the testing of drilling fluids concerning ecotoxicology, biological degradation, and toxicity. Two types of drilling fluids were tested for toxic effects on marine algae and biological degradability. A fluid based on mineral oil was readily degradable (98% DOC removal in 28 days) while an ether based oil degraded more slowly (56% DOC removal in 28 days). The toxicity of both fluids was tested after emulsification of the oils in water and separating the oil and water phase after equilibration. The EC 50 values obtained with this approach were 8.15 g/l for the oil based fluid and 116 g/l for the ether fluid. 9 figs., 8 tabs

  5. A two-phase debris-flow model that includes coupled evolution of volume fractions, granular dilatancy, and pore-fluid pressure

    Science.gov (United States)

    George, David L.; Iverson, Richard M.

    2011-01-01

    Pore-fluid pressure plays a crucial role in debris flows because it counteracts normal stresses at grain contacts and thereby reduces intergranular friction. Pore-pressure feedback accompanying debris deformation is particularly important during the onset of debrisflow motion, when it can dramatically influence the balance of forces governing downslope acceleration. We consider further effects of this feedback by formulating a new, depth-averaged mathematical model that simulates coupled evolution of granular dilatancy, solid and fluid volume fractions, pore-fluid pressure, and flow depth and velocity during all stages of debris-flow motion. To illustrate implications of the model, we use a finite-volume method to compute one-dimensional motion of a debris flow descending a rigid, uniformly inclined slope, and we compare model predictions with data obtained in large-scale experiments at the USGS debris-flow flume. Predictions for the first 1 s of motion show that increasing pore pressures (due to debris contraction) cause liquefaction that enhances flow acceleration. As acceleration continues, however, debris dilation causes dissipation of pore pressures, and this dissipation helps stabilize debris-flow motion. Our numerical predictions of this process match experimental data reasonably well, but predictions might be improved by accounting for the effects of grain-size segregation.

  6. The effect of increasing membrane curvature on the phase transition and mixing behavior of a dimyristoyl-sn-glycero-3-phosphatidylcholine/distearoyl-sn-glycero-3-phosphatidylcholine lipid mixture as studied by Fourier transform infrared spectroscopy and differential scanning calorimetry

    DEFF Research Database (Denmark)

    Brumm, T.; Jørgensen, Kent; Mouritsen, Ole G.

    1996-01-01

    The phase transition behavior of a lipid bilayer of dimyristoyl-sn-glycero-3-phosphalidylcholine/distearoyl-sn- glycero-3-phosphatidylcholine (DMPC-d54/DSPC) (1:1) on a solid support with varying curvatures was investigated with differential scanning calorimetry, infrared spectroscopy, and model...... of the liquidus point can be understood as a reduction of the lateral pressure in the bilayer with increasing curvature. The shift of the solidus line is interpreted as a result of the increased demixing of the two components in the two-phase region with increasing curvature due to lowering of the lateral...

  7. Rheological study of an hydrate slurry as secondary two-phase refrigerant. Experimental results and modelling; Etude rheologique d'une suspension d'hydrates en tant que fluide frigoporteur diphasique: resultats experimentaux et modelisation

    Energy Technology Data Exchange (ETDEWEB)

    Darbouret, M.

    2005-12-15

    Secondary two-phase fluids are suspensions of solid crystals. Thanks to the melting latent heat, they present a great interest for cold transportation. Moreover, they are a mean of reducing the amount of classical refrigerant. In the refrigeration field, ice slurries are already used. The goal is now to extend this technology to other temperature ranges suitable for other applications like freezing or air-conditioning. For an air-conditioning application, a TBAB (Tetra-Butyl-Ammonium Bromide) aqueous solution is studied. Under atmospheric pressure and for positive temperatures, this solution crystallizes into ice-like compounds named 'hydrates'. First, the physical properties of the aqueous solution and its crystallisation conditions were studied. Two different types of hydrates can appear. The goal of the experimental set-up is to study the rheological behaviour of two-phase fluids. Slurries are made in brushed-surface heat exchanger and pumped into pipes where flow rates and pressure drops are measured. The rheological behaviour of TBAB hydrates slurries can be described using a Bingham fluid model. We highlight that the two rheological parameters, which are the apparent viscosity and the yield shear stress, depend on the volume fraction of crystal of course, but also on the hydrate type, and on the initial concentration of the solution. The yield shear stress is interpreted as the consequence of the Van der Waals inter-particle interaction forces. Finally, possible stratification effects are modelled with a finite difference method. The principle is to calculate particle concentration and velocity profiles following the flow of the slurry. Calculations are validated with experimental velocity profiles published by P. Reghem (2002). This model underlines the influence of the particle distribution in the pipe on pressure drops. (author)

  8. Development of a Front Tracking Method for Two-Phase Micromixing of Incompressible Viscous Fluids with Interfacial Tension in Solvent Extraction

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Yijie [ORNL; Lim, Hyun-Kyung [ORNL; de Almeida, Valmor F [ORNL; Navamita, Ray [State University of New York, Stony Brook; Wang, Shuqiang [State University of New York, Stony Brook; Glimm, James G [ORNL; Li, Xiao-lin [State University of New York, Stony Brook; Jiao, Xiangmin [ORNL

    2012-06-01

    This progress report describes the development of a front tracking method for the solution of the governing equations of motion for two-phase micromixing of incompressible, viscous, liquid-liquid solvent extraction processes. The ability to compute the detailed local interfacial structure of the mixture allows characterization of the statistical properties of the two-phase mixture in terms of droplets, filaments, and other structures which emerge as a dispersed phase embedded into a continuous phase. Such a statistical picture provides the information needed for building a consistent coarsened model applicable to the entire mixing device. Coarsening is an undertaking for a future mathematical development and is outside the scope of the present work. We present here a method for accurate simulation of the micromixing dynamics of an aqueous and an organic phase exposed to intense centrifugal force and shearing stress. The onset of mixing is the result of the combination of the classical Rayleigh- Taylor and Kelvin-Helmholtz instabilities. A mixing environment that emulates a sector of the annular mixing zone of a centrifugal contactor is used for the mathematical domain. The domain is small enough to allow for resolution of the individual interfacial structures and large enough to allow for an analysis of their statistical distribution of sizes and shapes. A set of accurate algorithms for this application requires an advanced front tracking approach constrained by the incompressibility condition. This research is aimed at designing and implementing these algorithms. We demonstrate verification and convergence results for one-phase and unmixed, two-phase flows. In addition we report on preliminary results for mixed, two-phase flow for realistic operating flow parameters.

  9. Experimental study of arsenic speciation in vapor phase to 500°C: Implications for As transport and fractionation in low-density crustal fluids and volcanic gases.

    OpenAIRE

    Pokrovski , Gleb S.; Zakirov , Ildar V.; Roux , Jacques; Testemale , Denis; Hazemann , Jean-Louis; Y. U. Bychkov , Andrew; V. Golikova , Galina

    2002-01-01

    The stoichiometry and stability of arsenic gaseous complexes were determined in the system As-H2O ± NaCl ± HCl ± H2S at temperatures up to 500°C and pressures up to 600 bar, from both measurements of As(III) and As(V) vapor-liquid and vapor-solid partitioning, and X-ray absorption fine structure (XAFS) spectroscopic study of As(III)-bearing aqueous fluids. Vapor-aqueous solution partitioning for As(III) was measured from 250 to 450°C at the saturated vapor pressure of the system (Psat) with a...

  10. Temperature-controlled structure and kinetics of ripple phases in one- and two-component supported lipid bilayers

    DEFF Research Database (Denmark)

    Kaasgaard, Thomas; Leidy, Chad; Crowe, J.H.

    2003-01-01

    Temperature-controlled atomic force microscopy (AFM) has been used to visualize and study the structure and kinetics of ripple phases in one-component dipalmitoylphosphaticlylcholine (DPPC) and two-component dimyristoylphosphatidylcholine-distearoylphosphatidylcholine (DMPC-DSPC) lipid bilayers....... The lipid bilayers are mica-supported double bilayers in which ripple-phase formation occurs in the top bilayer. In one-component DPPC lipid bilayers, the stable and metastable ripple phases were observed. In addition, a third ripple structure with approximately twice the wavelength of the metastable...... ripples was seen. From height profiles of the AFM images, estimates of the amplitudes of the different ripple phases are reported. To elucidate the processes of ripple formation and disappearance, a ripple-phase DPPC lipid bilayer was taken through the pretransition in the cooling and the heating...

  11. Fluid Shifts

    Science.gov (United States)

    Stenger, M. B.; Hargens, A. R.; Dulchavsky, S. A.; Arbeille, P.; Danielson, R. W.; Ebert, D. J.; Garcia, K. M.; Johnston, S. L.; Laurie, S. S.; Lee, S. M. C.; hide

    2017-01-01

    Introduction. NASA's Human Research Program is focused on addressing health risks associated with long-duration missions on the International Space Station (ISS) and future exploration-class missions beyond low Earth orbit. Visual acuity changes observed after short-duration missions were largely transient, but now more than 50 percent of ISS astronauts have experienced more profound, chronic changes with objective structural findings such as optic disc edema, globe flattening and choroidal folds. These structural and functional changes are referred to as the visual impairment and intracranial pressure (VIIP) syndrome. Development of VIIP symptoms may be related to elevated intracranial pressure (ICP) secondary to spaceflight-induced cephalad fluid shifts, but this hypothesis has not been tested. The purpose of this study is to characterize fluid distribution and compartmentalization associated with long-duration spaceflight and to determine if a relation exists with vision changes and other elements of the VIIP syndrome. We also seek to determine whether the magnitude of fluid shifts during spaceflight, as well as any VIIP-related effects of those shifts, are predicted by the crewmember's pre-flight status and responses to acute hemodynamic manipulations, specifically posture changes and lower body negative pressure. Methods. We will examine a variety of physiologic variables in 10 long-duration ISS crewmembers using the test conditions and timeline presented in the figure below. Measures include: (1) fluid compartmentalization (total body water by D2O, extracellular fluid by NaBr, intracellular fluid by calculation, plasma volume by CO rebreathe, interstitial fluid by calculation); (2) forehead/eyelids, tibia, and calcaneus tissue thickness (by ultrasound); (3) vascular dimensions by ultrasound (jugular veins, cerebral and carotid arteries, vertebral arteries and veins, portal vein); (4) vascular dynamics by MRI (head/neck blood flow, cerebrospinal fluid

  12. Fluid mechanics

    International Nuclear Information System (INIS)

    Granger, R.A.

    1985-01-01

    This text offers the most comprehensive approach available to fluid mechanics. The author takes great care to insure a physical understanding of concepts grounded in applied mathematics. The presentation of theory is followed by engineering applications, helping students develop problem-solving skills from the perspective of a professional engineer. Extensive use of detailed examples reinforces the understanding of theoretical concepts

  13. A study of multi-phase flow through the cathode side of an interdigitated flow field using a multi-fluid model

    DEFF Research Database (Denmark)

    Berning, Torsten; Odgaard, Madeleine; Kær, Søren Knudsen

    2010-01-01

    This work presents a study of multi-phase flow through the cathode side of a polymer electrolyte membrane fuel cell employing an interdigitated flow field plate. A previously published model has been extended in order to account for phase change kinetics, and a comparison between the interdigitated...... flow field design and a conventional straight channel design has been conducted. It is found that the parasitic pressure drop in the interdigitated design is in the range of a few thousand Pa and could be reduced to a few hundred Pa by choosing diffusion media with high in-plane permeability....... In the interdigitated design more product water is carried out of the cell in the vapor phase compared to the straight channel design which indicates that liquid water management might be less problematic. This effect also leads to the finding that in the interdigitated design more waste heat is carried out of the cell...

  14. Mesoscopic model for binary fluids

    Science.gov (United States)

    Echeverria, C.; Tucci, K.; Alvarez-Llamoza, O.; Orozco-Guillén, E. E.; Morales, M.; Cosenza, M. G.

    2017-10-01

    We propose a model for studying binary fluids based on the mesoscopic molecular simulation technique known as multiparticle collision, where the space and state variables are continuous, and time is discrete. We include a repulsion rule to simulate segregation processes that does not require calculation of the interaction forces between particles, so binary fluids can be described on a mesoscopic scale. The model is conceptually simple and computationally efficient; it maintains Galilean invariance and conserves the mass and energy in the system at the micro- and macro-scale, whereas momentum is conserved globally. For a wide range of temperatures and densities, the model yields results in good agreement with the known properties of binary fluids, such as the density profile, interface width, phase separation, and phase growth. We also apply the model to the study of binary fluids in crowded environments with consistent results.

  15. Hollow fiber-based liquid phase microextraction combined with high-performance liquid chromatography for extraction and determination of some antidepressant drugs in biological fluids.

    Science.gov (United States)

    Esrafili, Ali; Yamini, Yadollah; Shariati, Shahab

    2007-12-05

    The applicability of hollow fiber-based liquid phase microextraction (HF-LPME) was evaluated for the extraction and preconcentration of three antidepressant drugs (amitriptyline, imipramine and sertraline) prior to their determination by HPLC-UV. The target drugs were extracted from 11.0 mL of aqueous solution with pH 12.0 (source phase) into an organic extracting solvent (n-dodecane) impregnated in the pores of a hollow fiber and finally back extracted into 24 microL of aqueous solution located inside the lumen of the hollow fiber and adjusted to pH 2.1 using 0.1M of H3PO4 (receiving phase). The extraction was performed due to pH gradient between the inside and outside of the hollow fiber membrane. In order to obtain high extraction efficiency, the parameters affecting the HF-LPME including pH of the source and receiving phases, the type of organic phase, ionic strength and volume of the source phase, stirring rate and extraction time were studied and optimized. Under the optimized conditions, enrichment factors up to 300 were achieved and the relative standard deviation (R.S.D.%) of the method was in the range of 2-12%. The calibration curves were obtained in the range of 5-500 microg L(-1) with reasonable linearity (R2>0.998) and the limits of detection (LODs) ranged between 0.5 and 0.7 microg L(-1) (based on S/N=3). Finally, the applicability of the proposed method was evaluated by extraction and determination of the drugs in urine, plasma and tap water samples. The results indicated that hollow fiber microextraction method has excellent clean-up and high-preconcentration factor and can be served as a simple and sensitive method for monitoring of antidepressant drugs in the biological samples.

  16. Investigating sub-2 μm particle stationary phase supercritical fluid chromatography coupled to mass spectrometry for chemical profiling of chamomile extracts.

    Science.gov (United States)

    Jones, Michael D; Avula, Bharathi; Wang, Yan-Hong; Lu, Lu; Zhao, Jianping; Avonto, Cristina; Isaac, Giorgis; Meeker, Larry; Yu, Kate; Legido-Quigley, Cristina; Smith, Norman; Khan, Ikhlas A

    2014-10-17

    Roman and German chamomile are widely used throughout the world. Chamomiles contain a wide variety of active constituents including sesquiterpene lactones. Various extraction techniques were performed on these two types of chamomile. A packed-column supercritical fluid chromatography-mass spectrometry method was designed for the identification of sesquiterpenes and other constituents from chamomile extracts with no derivatization step prior to analysis. Mass spectrometry detection was achieved by using electrospray ionization. All of the compounds of interest were separated within 15 min. The chamomile extracts were analyzed and compared for similarities and distinct differences. Multivariate statistical analysis including principal component analysis and orthogonal partial least squares-discriminant analysis (OPLS-DA) were used to differentiate between the chamomile samples. German chamomile samples confirmed the presence of cis- and trans-tonghaosu, chrysosplenols, apigenin diglucoside whereas Roman chamomile samples confirmed the presence of apigenin, nobilin, 1,10-epioxynobilin, and hydroxyisonobilin. Copyright © 2014 Elsevier B.V. All rights reserved.

  17. Influence of fluid-mechanical characteristics of the system on the volumetric mass transfer coefficient and gas dispersion in three-phase system

    Directory of Open Access Journals (Sweden)

    Knežević Milena M.

    2014-01-01

    Full Text Available Distribution of gas bubbles and volumetric mass transfer coefficient, Kla, in a three phase system, with different types of solid particles at different operation conditions were studied in this paper. The ranges of superficial gas and liquid velocities used in this study were 0,03-0,09 m/s and 0-0,1 m/s, respectively. The three different types of solid particles were used as a bed in the column (glass dp=3 mm, dp=6 mm; ceramic dp=6 mm. The experiments were carried out in a 2D plexiglas column, 278 x 20,4 x 500 mm and in a cylindrical plexiglas column, with a diameter of 64 mm and a hight of 2000 mm. The Kla coefficient increased with gas and liquid velocities. Results showed that the volumetric mass transfer coefficient has a higher values in three phase system, with solid particles, compared with two phase system. The particles properties (diameter and density have a major impact on oxygen mass transfer in three phase systems.

  18. SEMIAUTOMATED SOLID-PHASE EXTRACTION PROCEDURE FOR DRUG SCREENING IN BIOLOGICAL-FLUIDS USING THE ASPEC SYSTEM IN COMBINATION WITH CLEAN SCREEN DAU COLUMNS

    NARCIS (Netherlands)

    CHEN, XH; FRANKE, JP; ENSING, K; WIJSBEEK, J; DEZEEUW, RA

    1993-01-01

    The use of a semi-automated solid-phase extraction system (ASPEC) for the screening of drugs in plasma and urine on a single mixed-mode column (Clean Screen DAU) is described. The processes of column preconditioning, sample application, column wash, pH adjustment and elution of the drugs were

  19. Association of peripheral arterial disease with periodontal disease: analysis of inflammatory cytokines and an acute phase protein in gingival crevicular fluid and serum.

    Science.gov (United States)

    Çalapkorur, M Unlu; Alkan, B A; Tasdemir, Z; Akcali, Y; Saatçi, E

    2017-06-01

    Inflammation is a common feature of both peripheral arterial disease (PAD) and periodontal disease. The aim of this study was to evaluate the relationship between PAD and periodontal disease by examining the levels of inflammatory cytokines (pentraxin 3 and interleukin 1β) and high sensitive C-reactive protein from gingival crevicular fluid and serum. A total of 60 patients were included in this cross-sectional study. Patients were divided into two groups based on ankle-brachial index values: with PAD (test group) and non-PAD (control group). Demographic evaluations, clinical periodontal examinations and biochemical analysis for pentraxin 3, interleukin 1β and high sensitive C-reactive protein were performed to compare the two groups. There were no significant differences with respect to gender, age, body mass index, or smoking history (duration, amount) between the two groups (p > 0.05). There were no significant differences between the two groups in terms of clinical periodontal parameters (p > 0.05). Neither gingival crevicular fluid nor serum levels of the cytokines showed differences between the two groups. Logistic regression analysis revealed that, after adjusting for confounding factors (age, gender, diabetes, hypertension and body mass index), periodontitis raised the odds ratio for having PAD to 5.842 (95% confidence interval: 1.558-21.909). Although there were no significant differences with respect to clinical periodontal parameters and biochemical analyses between the study group and control, periodontitis did raise the odds ratio for having PAD. To clarify this possible relationship, future prospective studies are needed. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. Bioanalytical method development and validation for the determination of glycine in human cerebrospinal fluid by ion-pair reversed-phase liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Jiang, Jian; James, Christopher A; Wong, Philip

    2016-09-05

    A LC-MS/MS method has been developed and validated for the determination of glycine in human cerebrospinal fluid (CSF). The validated method used artificial cerebrospinal fluid as a surrogate matrix for calibration standards. The calibration curve range for the assay was 100-10,000ng/mL and (13)C2, (15)N-glycine was used as an internal standard (IS). Pre-validation experiments were performed to demonstrate parallelism with surrogate matrix and standard addition methods. The mean endogenous glycine concentration in a pooled human CSF determined on three days by using artificial CSF as a surrogate matrix and the method of standard addition was found to be 748±30.6 and 768±18.1ng/mL, respectively. A percentage difference of -2.6% indicated that artificial CSF could be used as a surrogate calibration matrix for the determination of glycine in human CSF. Quality control (QC) samples, except the lower limit of quantitation (LLOQ) QC and low QC samples, were prepared by spiking glycine into aliquots of pooled human CSF sample. The low QC sample was prepared from a separate pooled human CSF sample containing low endogenous glycine concentrations, while the LLOQ QC sample was prepared in artificial CSF. Standard addition was used extensively to evaluate matrix effects during validation. The validated method was used to determine the endogenous glycine concentrations in human CSF samples. Incurred sample reanalysis demonstrated reproducibility of the method. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. Dynamics, Surface Electrostatics and Phase Properties of Nanoscale Curved Lipid Bilayers

    Science.gov (United States)

    Koolivand, Amir

    Surface electrostatic potential of a lipid bilayer governs many vital functions of living cells. Several classes of proteins are known of exhibiting strong binding preferences to curved lipid bilayer surfaces. In this project we employed electron paramagnetic resonance (EPR) of a recently introduced phospholipid (IMTSL-PTE) bearing a pH-sensitive nitroxide covalently attached to the lipid head group to measure the surface electrostatics of the lipid membrane and nanopore-confined lipid bilayers as a function of the bilayer curvature. The pKa of the ionizable group of this lipid-based spin probe is reporting on the bilayer surface electrostatics potential by changes in the EPR spectra. Specifically, both rotational dynamics and magnetic parameters of the nitroxide are affected by the probe protonation. Effect of curvature on the surface electrostatic potential and dynamics of lipid bilayer was studied for POPG and DMPG unilamellar vesicles (ULVs). It was found that the magnitude of the negative surface electrostatic potential increased upon decrease in the vesicle diameter for the bilayers in the fluid phase; however, no significant changes were observed for DMPG ULVs in a gel phase. We speculate that biologically relevant fluid bilayer phase allows for a larger variability in the lipid packing density in the lipid polar head group region than a more ordered gel phase and it is likely that the lipid flip-flop is responsible for pH equilibration of IMTSL-PTE. The kinetic EPR study of nitroxide reduction showed that the rate of flip-flop is in the order of 10-5 s-1. The flip-flop rate constant increases when vesicle size deceases. Oxygen permeability measured by X-ban EPR decreases in higher curved vesicles---an observation that is consistent with a tighter packing in smaller vesicles. Partitioning of a small nitroxide molecule TEMPO into ULVs was measured by X-band (9 GHz) and W-band (95 GHz) EPR spectroscopy. The partitioning coefficient of this probe in the lipid

  2. Fluid dynamics of dilatant fluid

    DEFF Research Database (Denmark)

    Nakanishi, Hiizu; Nagahiro, Shin-ichiro; Mitarai, Namiko

    2012-01-01

    of the state variable, we demonstrate that the model can describe basic features of the dilatant fluid such as the stress-shear rate curve that represents discontinuous severe shear thickening, hysteresis upon changing shear rate, and instantaneous hardening upon external impact. An analysis of the model...

  3. Modelling and numerical simulation of two-phase flows using the two-fluid two-pressure approach; Modelisation et simulation numerique des ecoulements diphasiques par une approche bifluide a deux pressions

    Energy Technology Data Exchange (ETDEWEB)

    Guillemaud, V

    2007-03-15

    This thesis is devoted to the modelling and numerical simulation of liquid-vapor flows. In order to describe these phase transition flows, a two-fluid two-pressure approach is considered. This description of the liquid-vapor mixing is associated to the seven-equation model introduced by Baer and Nunziato. This work investigates the properties of this model in order to simulate the phase transition flows occurring in nuclear engineering. First, a theoretical thermodynamic framework is constructed to describe the liquid-vapor mixing. Provided with this framework, various modelling choices are suggested for the interaction terms between the phases. These closure laws comply with an entropy inequality. The mathematical properties of this model are thereafter examined. The convective part is associated to a nonconservative hyperbolic system. First, we focus on the definition of its weak solutions. Several flow regimes for the two-phase mixing derive from this analysis. Such regimes for the two-phase flows are analogous to the torrential and fluvial regimes for the shallow-water equations. Furthermore, we establish the linear and nonlinear stabilities of the liquid-vapor equilibrium. Finally, the implementation of a turbulence model and the introduction of a reconstruction process for the interfacial area are investigated in order to refine the description of the interfacial transfers. Using a fractional step approach, a Finite Volume method is at last constructed to simulate this model. First, various nonconservative adaptations of standard Riemann solvers are developed to approach the convective part. Unlike the classic nonconservative framework, these schemes converge towards the same solution. Furthermore, a new relaxation scheme is proposed to approach the interfacial transfers. Provided with these schemes, the whole numerical method preserves the liquid-vapor equilibria. Using this numerical method, a careful comparison between the one- and two-pressure two-fluid

  4. Coulombic Fluids Bulk and Interfaces

    CERN Document Server

    Freyland, Werner

    2011-01-01

    Ionic liquids have attracted considerable interest in recent years. In this book the bulk and interfacial physico-chemical characteristics of various fluid systems dominated by Coulomb interactions are treated which includes molten salts, ionic liquids as well as metal-molten salt mixtures and expanded fluid metals. Of particular interest is the comparison of the different systems. Topics in the bulk phase concern the microscopic structure, the phase behaviour and critical phenomena, and the metal-nonmetal transition. Interfacial phenomena include wetting transitions, electrowetting, surface freezing, and the electrified ionic liquid/ electrode interface. With regard to the latter 2D and 3D electrochemical phase formation of metals and semi-conductors on the nanometer scale is described for a number of selected examples. The basic concepts and various experimental methods are introduced making the book suitable for both graduate students and researchers interested in Coulombic fluids.

  5. Fluid flow and radionuclide transport in complex repository mines. Synthesis report part 1/2. Two-phase flow in a saline repository using the example ERAM; Fluidstroemung und Radionuklidtransport in komplexen Endlagerbergwerken. Synthesebericht Teil 1/2. Zweiphasenfluss in einem salinaren Endlager am Beispiel des ERAM

    Energy Technology Data Exchange (ETDEWEB)

    Kock, Ingo; Frieling, Gerd; Navarro, Martin

    2016-10-15

    The aim of the project is the understanding of two-phase flow processes in a complex final repository system. The consideration of two-phase flow processes for calculations concerning the modeled final repository system induces processes and effects that influence the fluid and radionuclide transport significantly. Two-phase flow processes cover not only capillary pressures and the relative permeability but also a basic competition of phases for the pore volume with respect to storage and transport and density driven vertical phase separation.

  6. Phase-contrast cerebrospinal fluid flow magnetic resonance imaging in qualitative evaluation of patency of CSF flow pathways prior to infusion of chemotherapeutic and other agents into the fourth ventricle.

    Science.gov (United States)

    Patel, Rajan P; Sitton, Clark W; Ketonen, Leena M; Hou, Ping; Johnson, Jason M; Romo, Seferino; Fletcher, Stephen; Shah, Manish N; Kerr, Marcia; Zaky, Wafik; Rytting, Michael E; Khatua, Soumen; Sandberg, David I

    2018-03-01

    Nuclear medicine studies have previously been utilized to assess for blockage of cerebrospinal fluid (CSF) flow prior to intraventricular chemotherapy infusions. To assess CSF flow without nuclear medicine studies, we obtained cine phase-contrast MRI sequences that assess CSF flow from the fourth ventricle down to the sacrum. In three clinical trials, 18 patients with recurrent malignant posterior fossa tumors underwent implantation of a ventricular access device (VAD) into the fourth ventricle, either with or without simultaneous tumor resection. Prior to infusing therapeutic agents into the VAD, cine MRI phase-contrast CSF flow sequences of the brain and total spine were performed. Velocity encoding (VENC) of 5 and 10 cm/s was used to confirm CSF flow from the fourth ventricular outlets to the cervical, thoracic, and lumbar spine. Qualitative CSF flow was characterized by neuroradiologists as present or absent. All 18 patients demonstrated CSF flow from the outlets of the fourth ventricle down to the sacrum with no evidence of obstruction. One of these patients, after disease progression, subsequently showed obstruction of CSF flow. No patient required a nuclear medicine study to assess CSF flow prior to initiation of infusions. Fourteen patients have received infusions to date, and none has had neurological toxicity. CSF flow including the fourth ventricle and the total spine can be assessed noninvasively with phase-contrast MRI sequences. Advantages over nuclear medicine studies include avoiding both an invasive procedure and radiation exposure.

  7. Cryogenic Fluid Management Facility

    Science.gov (United States)

    Eberhardt, R. N.; Bailey, W. J.

    1985-01-01

    The Cryogenic Fluid Management Facility is a reusable test bed which is designed to be carried within the Shuttle cargo bay to investigate the systems and technologies associated with the efficient management of cryogens in space. Cryogenic fluid management consists of the systems and technologies for: (1) liquid storage and supply, including capillary acquisition/expulsion systems which provide single-phase liquid to the user system, (2) both passive and active thermal control systems, and (3) fluid transfer/resupply systems, including transfer lines and receiver tanks. The facility contains a storage and supply tank, a transfer line and a receiver tank, configured to provide low-g verification of fluid and thermal models of cryogenic storage and transfer processes. The facility will provide design data and criteria for future subcritical cryogenic storage and transfer system applications, such as Space Station life support, attitude control, power and fuel depot supply, resupply tankers, external tank (ET) propellant scavenging, and ground-based and space-based orbit transfer vehicles (OTV).

  8. Fluid dynamics

    CERN Document Server

    Ruban, Anatoly I

    This is the first book in a four-part series designed to give a comprehensive and coherent description of Fluid Dynamics, starting with chapters on classical theory suitable for an introductory undergraduate lecture course, and then progressing through more advanced material up to the level of modern research in the field. The present Part 1 consists of four chapters. Chapter 1 begins with a discussion of Continuum Hypothesis, which is followed by an introduction to macroscopic functions, the velocity vector, pressure, density, and enthalpy. We then analyse the forces acting inside a fluid, and deduce the Navier-Stokes equations for incompressible and compressible fluids in Cartesian and curvilinear coordinates. In Chapter 2 we study the properties of a number of flows that are presented by the so-called exact solutions of the Navier-Stokes equations, including the Couette flow between two parallel plates, Hagen-Poiseuille flow through a pipe, and Karman flow above an infinite rotating disk. Chapter 3 is d...

  9. Alfvén wave filamentation and dispersive phase mixing in a high-density channel: Landau fluid and hybrid simulations

    Czech Academy of Sciences Publication Activity Database

    Borgogno, D.; Hellinger, Petr; Passot, T.; Sulem, P. L.; Trávníček, Pavel M.

    2009-01-01

    Roč. 16, č. 2 (2009), s. 275-285 ISSN 1023-5809 R&D Projects: GA AV ČR IAA300420702 Institutional research plan: CEZ:AV0Z30420517; CEZ:AV0Z10030501 Keywords : Alfven wave * phase mixing * filamentation Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.152, year: 2009 http://www.nonlin-processes-geophys.net/16/275/2009/npg-16-275-2009.pdf

  10. A numerical analysis of an anisotropic phase-field model for binary-fluid mixtures in the presence of magnetic-field

    OpenAIRE

    Belmiloudi , Aziz; Rasheed , Amer

    2015-01-01

    In this paper we propose a numerical scheme and perform its numerical analysis devoted to an anisotropic phase-field model with convection under the influence of magnetic field for the isother-mal solidification of binary mixtures in two-dimensional geometry. Precisely, the numerical stability and error analysis of this approximation scheme which is based on mixed finite-element method are performed. The particular application of a nickelcopper (NiCu) binary alloy, with real physical paramete...

  11. Computational Fluid Dynamics-Population Balance Model Simulation of Effects of Cell Design and Operating Parameters on Gas-Liquid Two-Phase Flows and Bubble Distribution Characteristics in Aluminum Electrolysis Cells

    Science.gov (United States)

    Zhan, Shuiqing; Wang, Junfeng; Wang, Zhentao; Yang, Jianhong

    2018-02-01

    The effects of different cell design and operating parameters on the gas-liquid two-phase flows and bubble distribution characteristics under the anode bottom regions in aluminum electrolysis cells were analyzed using a three-dimensional computational fluid dynamics-population balance model. These parameters include inter-anode channel width, anode-cathode distance (ACD), anode width and length, current density, and electrolyte depth. The simulations results show that the inter-anode channel width has no significant effect on the gas volume fraction, electrolyte velocity, and bubble size. With increasing ACD, the above values decrease and more uniform bubbles can be obtained. Different effects of the anode width and length can be concluded in different cell regions. With increasing current density, the gas volume fraction and electrolyte velocity increase, but the bubble size keeps nearly the same. Increasing electrolyte depth decreased the gas volume fraction and bubble size in particular areas and the electrolyte velocity increased.

  12. A mixed markers and volume-of-fluid method for the reconstruction and advection of interfaces in two-phase and free-boundary flows

    International Nuclear Information System (INIS)

    Aulisa, Eugenio; Manservisi, Sandro; Scardovelli, Ruben

    2003-01-01

    In this work we present a new mixed markers and volume-of-fluid (VOF) algorithm for the reconstruction and advection of interfaces in the two-dimensional space. The interface is described by using both the volume fraction function C, as in VOF methods, and surface markers, which locate the interface within the computational cells. The C field and the markers are advected by following the streamlines. New markers are determined by computing the intersections of the advected interface with the grid lines, then other markers are added inside each cut cell to conserve the volume fraction C. A smooth motion of the interface is obtained, typical of the marker approach, with a good volume conservation, as in standard VOF methods. In this article we consider a few typical two-dimensional tests and compare the results of the mixed algorithm with those obtained with VOF methods. Translations, rotations and vortex tests are performed showing that many problems of the VOF technique can be solved and a good accuracy in the geometrical motion and mass conservation can be achieved

  13. Simultaneous high speed digital cinematographic and X-ray radiographic imaging of a intense multi-fluid interaction with rapid phase changes

    Energy Technology Data Exchange (ETDEWEB)

    Hansson, Roberta Concilio; Park, Hyun Sun; Dinh, Truc-Nam [Royal Institute of Technology, Division of Nuclear Power Safety, AlbaNova, Stockholm SE-106 91 (Sweden)

    2009-04-15

    As typical for the study of the vapor explosions, the qualitative and quantitative understanding of the phenomena requires visualization of both material and interface dynamics. A new approach to multi-fluid multiphase visualization is presented with the focus on the development of a synchronized high-speed visualization by digital cinematography and X-ray radiography. The developed system, named SHARP (simultaneous high-speed acquisition of X-ray radiography and photography), and its image processing methodology, directed to an image synchronization procedure and a separate quantification of vapor and molten material dynamics, is presented in this paper. Furthermore, we exploit an intrinsic property of the X-ray radiation, namely the differences in linear mass attenuation coefficients over the beam path through a multi-component system, to characterize the evolution of molten material distribution. Analysis of the data obtained by the SHARP system and image processing procedure developed granted new insights into the physics of the vapor explosion phenomena, as well as, quantitative information of the associated dynamic micro-interactions. (author)

  14. Graphene-coated polystyrene-divinylbenzene dispersive solid-phase extraction coupled with supercritical fluid chromatography for the rapid determination of 10 allergenic disperse dyes in industrial wastewater samples.

    Science.gov (United States)

    Lou, Chaoyan; Wu, Can; Zhang, Kai; Guo, Dandan; Jiang, Lei; Lu, Yang; Zhu, Yan

    2018-05-18

    Allergenic disperse dyes are a group of environmental contaminants, which are toxic and mutagenic to human beings. In this work, a method of dispersive solid-phase extraction (d-SPE) using graphene-coated polystyrene-divinylbenzene (G@PS-DVB) microspheres coupled with supercritical fluid chromatography (SFC) was proposed for the rapid determination of 10 allergenic disperse dyes in industrial wastewater samples. G@PS-DVB microspheres were synthesized by coating graphene (G) sheets onto polystyrene-divinylbenzene (PS-DVB) polymers. Such novel sorbents were employed in d-SPE for the purification and concentration of allergenic disperse dyes in wastewater samples prior to the determination by SFC with UV detection. To achieve the maximum extraction efficiency for the target dyes, several parameters influencing d-SPE process such as sorbent dosage, extraction time, desorption conditions were investigated. SFC conditions including stationary phase, modifier composition and percentage, column temperature, backpressure and flow rate were optimized to well separate the allergenic disperse dyes. Under the optimum conditions, satisfactory linear relationship (R ≥ 0.9989) was observed with the concentration of dyes ranging from 0.02 to 10.0 μg/mL. The limits of detection (LOD, S/N = 3) for the ten dyes were in the range of 1.1-15.6 ng/mL. Recoveries for the spiked samples were between 89.1% and 99.7% with relative standard deviations (RSD) lower than 10.5% in all cases. The proposed method is time-saving, green, precise and repeatable for the analysis of the target dyes. Furthermore, the application of G@PS-DVB based d-SPE process can be potentially expanded to isolate and concentrate other aromatic compounds in various matrices and supercritical fluid chromatography methodology featuring rapidity, accuracy and green will be an ideal candidate for the analysis of these compounds. Copyright © 2018 Elsevier B.V. All rights reserved.

  15. Correlation between protein kinase C alpha activity and membrane phase behavior.

    Science.gov (United States)

    Micol, V; Sánchez-Piñera, P; Villalaín, J; de Godos, A; Gómez-Fernández, J C

    1999-02-01

    Lipid activation of protein kinase C alpha (PKC alpha) was studied by using a model mixture containing 1, 2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC), 1, 2-dimyristoyl-sn-glycero-3-phosphoserine (DMPS), and 1, 2-dimyristoyl-sn-glycerol (1,2-DMG). This lipid mixture was physically characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and 31P-nuclear magnetic resonance (31P-NMR). Based on these techniques, a phase diagram was constructed by keeping a constant DMPC/DMPS molar ratio of 4:1 and changing the concentration of 1,2-DMG. This phase diagram displayed three regions and two compounds: compound 1 (C1), with 45 mol% 1,2-DMG, and compound 2 (C2), with 60 mol% 1,2-DMG. When the phase diagram was elaborated in the presence of Ca2+ and Mg2+, at concentrations similar to those used in the PKC alpha activity assay, the boundaries between the regions changed slightly and C1 had 35 mol% 1,2-DMG. The activity of PKC alpha was studied at several temperatures and at different concentrations of 1,2-DMG, with a maximum of activity reached at 30 mol% 1,2-DMG and lower values at higher concentrations. In the presence of Ca2+ and Mg2+, maximum PKC alpha activity occurred at concentrations of 1,2-DMG that were close to the boundary in the phase diagram between region 1, where compound C1 and the pure phospholipid coexisted in the gel phase, and region 2, where compounds C1 and C2 coexisted. These results suggest that the membrane structure corresponding to a mixture of 1,2-DMG/phospholipid complex and free phospholipid is better able to support the activity of PKC alpha than the 1,2-DMG/phospholipid complex alone.

  16. Formation of intermetallic phases in AlSi7Fe1 alloy processed under microgravity and forced fluid flow conditions and their influence on the permeability

    OpenAIRE

    Steinbach, Sonja; Ratke, Lorenz; Zimmermann, Gerhard; Budenkova, Olga

    2016-01-01

    Ternary Al-6.5wt.%Si-0.93wt.%Fe alloy samples were directionally solidified on-board of the International Space Station ISS in the ESA payload Materials Science Laboratory (MSL) equipped with Low Gradient Furnace (LGF) under both purely diffusive and stimulated convective conditions induced by a rotating magnetic field. Using different analysis techniques the shape and distribution of the intermetallic phase β-Al 5 SiFe in the dendritic microstructure was investigated, to study the influence ...

  17. A simple computational method for predicting magnetic field in the vicinity of a three-phase underground cable with a fluid-filled steel-pipe enclosure

    International Nuclear Information System (INIS)

    Xu, X.B.; Yang, X.M.

    1994-01-01

    This paper presents a simple computational method for predicting the magnetic field above ground, generated by an underground three-phase pipe-type cable. In the computation, an approximation is made to simplify the problem a Fourier series technique and an iterative procedure are employed to handle the nonlinear B-H characteristic of the steel pipe. To validate the computational method, measurements were made and the numerical results are compared with the measurement data. Also, data of magnetic fields generated by the pipe type cable are compared with those due to the cable in absence of the pipe. The advantages and disadvantages of this simple method are discussed

  18. An UHPLC-MS/MS method for simultaneous quantification of human amyloid beta peptides Aβ1-38, Aβ1-40 and Aβ1-42 in cerebrospinal fluid using micro-elution solid phase extraction.

    Science.gov (United States)

    Lin, Ping-Ping; Chen, Wei-Li; Yuan, Fei; Sheng, Lei; Wu, Yu-Jia; Zhang, Wei-Wei; Li, Guo-Qing; Xu, Hong-Rong; Li, Xue-Ning

    2017-12-01

    Amyloid beta (Aβ) peptides in cerebrospinal fluid are extensively estimated for identification of Alzheimer's disease (AD) as diagnostic biomarkers. Unfortunately, their pervasive application is hampered by interference from Aβ propensity of self-aggregation, nonspecifically bind to surfaces and matrix proteins, and by lack of quantitive standardization. Here we report on an alternative Ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for simultaneous measurement of human amyloid beta peptides Aβ1-38, Aβ1-40 and Aβ1-42 in cerebrospinal fluid (CSF) using micro-elution solid phase extraction (SPE). Samples were pre-processing by the mixed-mode micro-elution solid phase extraction and quantification was performed in the positive ion multiple reaction monitoring (MRM) mode using electrospray ionization. The stable-isotope labeled Aβ peptides 15 N 51 - Aβ1-38, 15 N 53 - Aβ1-40 and 15 N 55 - Aβ1-42 peptides were used as internal standards. And the artificial cerebrospinal fluid (ACSF) containing 5% rat plasma was used as a surrogate matrix for calibration curves. The quality control (QC) samples at 0.25, 2 and 15ng/mL were prepared. A "linear" regression (1/x 2 weighting): y=ax+b was used to fit the calibration curves over the concentration range of 0.1-20ng/mL for all three peptides. Coefficient of variation (CV) of intra-batch and inter-batch assays were all less than 6.44% for Aβ1-38, 6.75% for Aβ1-40 and 10.74% for Aβ1-42. The precision values for all QC samples of three analytes met the acceptance criteria. Extract recoveries of Aβ1-38, Aβ1-40 and Aβ1-42 were all greater than 70.78%, both in low and high QC samples. The stability assessments showed that QC samples at both low and high levels could be stable for at least 24h at 4°C, 4h at room temperature and through three freeze-thaw cycles without sacrificing accuracy or precision. And no significant carryover effect was observed. This validated UHPLC

  19. Fluid mechanics

    International Nuclear Information System (INIS)

    Paraschivoiu, I.; Prud'homme, M.; Robillard, L.; Vasseur, P.

    2003-01-01

    This book constitutes at the same time theoretical and practical base relating to the phenomena associated with fluid mechanics. The concept of continuum is at the base of the approach developed in this work. The general advance proceeds of simple balances of forces as into hydrostatic to more complex situations or inertias, the internal stresses and the constraints of Reynolds are taken into account. This advance is not only theoretical but contains many applications in the form of solved problems, each chapter ending in a series of suggested problems. The major part of the applications relates to the incompressible flows

  20. Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. I: Investigation of mobile phase and MS conditions.

    Science.gov (United States)

    Nováková, Lucie; Grand-Guillaume Perrenoud, Alexandre; Nicoli, Raul; Saugy, Martial; Veuthey, Jean-Luc; Guillarme, Davy

    2015-01-01

    The conditions for the analysis of selected doping substances by UHPSFC-MS/MS were optimized to ensure suitable peak shapes and maximized MS responses. A representative mixture of 31 acidic and basic doping agents was analyzed, in both ESI+ and ESI- modes. The best compromise for all compounds in terms of MS sensitivity and chromatographic performance was obtained when adding 2% water and 10mM ammonium formate in the CO2/MeOH mobile phase. Beside mobile phase, the nature of the make-up solvent added for interfacing UHPSFC with MS was also evaluated. Ethanol was found to be the best candidate as it was able to compensate for the negative effect of 2% water addition in ESI- mode and provided a suitable MS response for all doping agents. Sensitivity of the optimized UHPSFC-MS/MS method was finally assessed and compared to the results obtained in conventional UHPLC-MS/MS. Sensitivity was improved by 5-100-fold in UHPSFC-MS/MS vs. UHPLC-MS/MS for 56% of compounds, while only one compound (bumetanide) offered a significantly higher MS response (4-fold) under UHPLC-MS/MS conditions. In the second paper of this series, the optimal conditions for UHPSFC-MS/MS analysis will be employed to screen >100 doping agents in urine matrix and results will be compared to those obtained by conventional UHPLC-MS/MS. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Determination of Biogenic Amines in Rumen Fluid by Reverse Phase-High Performance Liquid Chromatography%反相高效液相色谱法测定瘤胃液中的生物胺

    Institute of Scientific and Technical Information of China (English)

    王东升; 霍文婕; 朱伟云; 毛胜勇

    2011-01-01

    This study was conducted to establish a method of simultaneously detecting concentration of biogenic amine in rumen fluid by reverse phase-high performance liquid chromatography ( RP-HPLC). Samples were extracted by hydrochloric acid (0. 5 mol/L) , and then derived using dansyl chloride, the mobile phase was a gradient elution program with a binary mixture of acetonitrile and 0. 1 mol/L ammonium acetate and the flow rate was 1 mL/min; the wavelength of UV detector was 254 nm, and the column temperature was 30 t. The method was then used to investigate the effect of diet forage-to-concentrate ratio on concentrations of the five biogenic amines in rumen fluid of goats. The results showed that a good separation of tryptamine, putrescine, methylamine, histamine and tyramine was seen within 40 min, and the average recovery were ranged from 88. 46% to 98. 49% , and the relative standard deviations were less than 10% ; Compared with goats fed low concentrate diet, tryptamine and histamine concentrations in rumen fluid of goats fed high concentrate diet were significantly higher (P 0. 05). The results indicate that this method presented here can be used to determine biogenic amine concentrations in rumen fluid, and concentrations of biogenic amine in rumen fluid of goats can be affected by diet forage-to-concentrate ratio.%本文旨在应用反相高效液相色谱法建立瘤胃液中生物胺的测定方法.样品经0.5 mol/L盐酸提取后,用丹磺酰氯柱前衍生,流动相为乙腈和0.1 mol/L乙酸铵溶液;采用梯度洗脱,流速为1.0 mL/min;紫外检测器波长254 nm,柱温30℃.应用该方法,研究高精料和低精料饲粮条件下瘤胃液中5种生物胺浓度的差异.结果表明:采用该方法,色胺、腐胺、甲胺、组胺和酪胺5种生物胺能在40 min内得到良好地分离,回收率为88.46%~98.49%,相对标准偏差小于10%.在高精料饲粮条件下,饲喂前山羊瘤胃液中的酪胺和甲胺浓度

  2. On the efficiency of a fluid-fluid centrifugal separation

    International Nuclear Information System (INIS)

    Apazidis, N.

    1984-05-01

    Efficiency of a separation process of two immiscible incompressible fluids of different densities occuring under the influence of a combined centrifugal and gravitational force field is investigated. The analysis is based on the set of equations for a rotating two-phase flow of a mixture as presented by Greenspan (1983). The geometry of the separation process is considered and the total flow of the separated phases evaluated. (author)

  3. Principles of fluid mechanics

    International Nuclear Information System (INIS)

    Kreider, J.F.

    1985-01-01

    This book is an introduction on fluid mechanics incorporating computer applications. Topics covered are as follows: brief history; what is a fluid; two classes of fluids: liquids and gases; the continuum model of a fluid; methods of analyzing fluid flows; important characteristics of fluids; fundamentals and equations of motion; fluid statics; dimensional analysis and the similarity principle; laminar internal flows; ideal flow; external laminar and channel flows; turbulent flow; compressible flow; fluid flow measurements

  4. Proceedings of the users meeting on structure and phase transition of phospholipid membrane

    International Nuclear Information System (INIS)

    Hatta, Ichiro; Amemiya, Yoshiyuki

    1994-06-01

    On the occasion that the persons of three groups that have carried out the research on the structure and the phase transition of phospholipid membranes have carried out the experiment successively, the users meeting was held on November 1, 1993 at National Laboratory for High Energy Physics. Lectures were given on the L βI structure of DPPC/alcohol system, the self gathering and intermolecular cooperation phenomenon of glycero phospholipid, the phase transition of DEPE/water system, the structure of DMPA/polylysine, the development of X-ray television, the ripple structure of DMPC/cholesterol system and the simultaneous measurement of X-ray diffraction/DSC. To have the chance like this is very meaningful because sufficient discussion can be done among usually busy researchers at the synchrotron radiation experiment facility. (K.I.)

  5. Proceedings of the users meeting on structure and phase transition of phospholipid membrane

    Energy Technology Data Exchange (ETDEWEB)

    Hatta, Ichiro [Nagoya Univ. (Japan). School of Engineering; Amemiya, Yoshiyuki [eds.

    1994-06-01

    On the occasion that the persons of three groups that have carried out the research on the structure and the phase transition of phospholipid membranes have carried out the experiment successively, the users meeting was held on November 1, 1993 at National Laboratory for High Energy Physics. Lectures were given on the L{sub {beta}I} structure of DPPC/alcohol system, the self gathering and intermolecular cooperation phenomenon of glycero phospholipid, the phase transition of DEPE/water system, the structure of DMPA/polylysine, the development of X-ray television, the ripple structure of DMPC/cholesterol system and the simultaneous measurement of X-ray diffraction/DSC. To have the chance like this is very meaningful because sufficient discussion can be done among usually busy researchers at the synchrotron radiation experiment facility. (K.I.).

  6. Isostructural solid-solid transition of (colloidal) simple fluids

    International Nuclear Information System (INIS)

    Tejero, C.F.; Daanoun, A.; Lakkerkerker, H.N.W.; Baus, M.

    1995-01-01

    A variational approach based on the Gibbs-Bogoliubov inequality is used in order to evaluate the free energy of simple fluids described by a double-Yukawa pair potential. A hard-sphere reference fluid is used to describe the fluid phases, and an Einstein reference crystal to describe the solid phases. Apart from the usual type of phase diagram, typical of atomic simple fluids with long-ranged attractions, we find two types of phase diagrams, specific to colloidal systems with intermediate and short-ranged attractions. One of the latter phase diagrams exhibits an isostructural solid-solid transition, which has not yet been observed experimentally

  7. Disappearing fluid?

    International Nuclear Information System (INIS)

    Graney, K.; Chu, J.; Lin, P.C.

    2002-01-01

    Full text: A 78-year old male in end stage renal failure (ESRF) with a background of NIDDM retinopathy, nephropathy, and undergoing continuous ambulatory peritoneal dialysis (CAPD) presented with anorexia, clinically unwell, decreased mobility and right scrotal swelling. There was no difficulty during CAPD exchange except there was a positive fluid balance Peritoneal dialysates remained clear A CAPD peritoneal study was requested. 100Mbq 99mTc Sulphur Colloid was injected into a standard dialysate bag containing dialysate. Anterior dynamic images were acquired over the abdomen pelvis while the dialysate was infused Static images with anatomical markers were performed 20 mins post infusion, before and after patient ambulation and then after drainage. The study demonstrated communication between the peritoneal cavity and the right scrotal sac. Patient underwent right inguinal herniaplasty with a marlex mesh. A repeat CAPD flow study was performed as follow up and no abnormal connection between the peritoneal cavity and the right scrotal sac was demonstrated post operatively. This case study shows that CAPD flow studies can be undertaken as a simple, minimally invasive method to evaluate abnormal peritoneal fluid flow dynamics in patients undergoing CAPD, and have an impact on dialysis management. Copyright (2002) The Australian and New Zealand Society of Nuclear Medicine Inc

  8. Auxillary Fluid Flowmeter

    DEFF Research Database (Denmark)

    RezaNejad Gatabi, Javad; Forouzbakhsh, Farshid; Ebrahimi Darkhaneh, Hadi

    2010-01-01

    The Auxiliary Fluid Flow meter is proposed to measure the fluid flow of any kind in both pipes and open channels. In this kind of flow measurement, the flow of an auxiliary fluid is measured Instead of direct measurement of the main fluid flow. The auxiliary fluid is injected into the main fluid ...

  9. Temperature measurements in fluid flows (eventually reactive, multi-phase...) using optical methods; Mesure des temperatures dans les ecoulements (eventuellement reactifs, multiphasiques...) par methodes optiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-12-31

    This conference day was organized by the `radiations` section of the French association of thermal engineers. This book of proceedings contains 8 papers entitled: `simultaneous temperature and NO concentration measurements in a hydrogen-air turbulent flame`; `application of iodine laser induced fluorescence to temperature, pressure and velocity measurements`; `Doppler phase measurement of refractive index and temperature`; `experimental and numerical study of temperature fields of particulates in plasma jets`; `measurement and determination of temperatures and concentrations of hot exhaust gases with FTIR emission spectroscopy`; `combustion control in gas turbines using CO{sub 2} emission spectroscopy`; `analysis of gases temperature fields and particulate jets. Application to hydrogen-air, kerosene stato-reactors and to solid propellant jets`; `restitution of temperature and species profiles in pre-mixing flames by inversion of transmission and IR emission data. (J.S.)

  10. Thermodynamic properties of fluid mixtures at high pressures and high temperatures. Application to high explosives and to phase diagrams of binary mixtures

    International Nuclear Information System (INIS)

    Pittion-Rossillon, Gerard

    1982-01-01

    The free energy for mixtures of about ten species which are chemically reacting is calculated. In order to have accurate results near the freezing line, excess properties are deduced from a modern statistical mechanics theory. Intermolecular potentials for like molecules are fitted to give good agreement with shock experiments in pure liquid samples, and mixture properties come naturally from the theory. The stationary Chapman-Jouguet detonation wave is calculated with a chemical equilibrium computer code and results are in good agreement with experiment for a lot of various explosives. One then study gas-gas equilibria in a binary mixture and show the extreme sensitivity of theoretical phase diagrams to the hypothesis of the model (author) [fr

  11. Temperature measurements in fluid flows (eventually reactive, multi-phase...) using optical methods; Mesure des temperatures dans les ecoulements (eventuellement reactifs, multiphasiques...) par methodes optiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    This conference day was organized by the `radiations` section of the French association of thermal engineers. This book of proceedings contains 8 papers entitled: `simultaneous temperature and NO concentration measurements in a hydrogen-air turbulent flame`; `application of iodine laser induced fluorescence to temperature, pressure and velocity measurements`; `Doppler phase measurement of refractive index and temperature`; `experimental and numerical study of temperature fields of particulates in plasma jets`; `measurement and determination of temperatures and concentrations of hot exhaust gases with FTIR emission spectroscopy`; `combustion control in gas turbines using CO{sub 2} emission spectroscopy`; `analysis of gases temperature fields and particulate jets. Application to hydrogen-air, kerosene stato-reactors and to solid propellant jets`; `restitution of temperature and species profiles in pre-mixing flames by inversion of transmission and IR emission data. (J.S.)

  12. Simultaneous Screening and Quantification of 29 Drugs of Abuse in Oral Fluid by Solid-Phase Extraction and Ultraperformance LC-MS/MS

    DEFF Research Database (Denmark)

    Linnet, Kristian; Badawi, Nora; Simonsen, Kirsten W.

    2009-01-01

    performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method for detection of 29 drugs and illicit compounds in OF. The drugs detected were opioids, amphetamines, cocaine, benzodiazepines, and {Delta}-9-tetrahydrocannabinol. Method: Solid-phase extraction was performed with a Gilson ASPEC XL......4 system equipped with Bond Elut Certify sample cartridges. OF samples (200 mg) diluted with 5 mL of ammonium acetate/methanol (vol/vol 90:10) buffer were applied to the columns and eluted with 3 mL of acetonitrile with aqueous ammonium hydroxide. Target drugs were quantified by use of a Waters...... of amphetamine, cocaine, codeine, {Delta}-9-tetrahydrocannabinol, tramadol, and zopiclone. Conclusions: The UPLC-MS/MS method makes it possible to detect all 29 analytes in 1 chromatographic run (15 min), including {Delta}-9-tetrahydrocannabinol and benzoylecgonine, which previously have been difficult...

  13. Solid-phase extraction based on hydrophilic interaction liquid chromatography with acetone as eluent for eliminating matrix effects in the analysis of biological fluids by LC-MS.

    Science.gov (United States)

    Van Damme, T; Lachová, M; Lynen, F; Szucs, R; Sandra, P

    2014-01-01

    Analysis of drugs and metabolites in biological matrices such as blood or plasma by LC-MS is routinely challenged by the presence of large quantities of competing molecules for ionization in soft ionization sources, such as proteins and phospholipids. While the former can easily be removed by protein precipitation, pre-analytical extraction of the latter is necessary because they show very high retention in reversed-phase LC resulting in long analysis times or in ion suppression effects when not eluted before the next runs. A novel HILIC-based SPE approach, making use of silica cartridges and of acetone as organic solvent, is introduced as a potent alternative to current commercial methods for phospholipid removal. The methodology was developed and tested for a broad polarity range of pharmaceutical solutes (log P from 0 to 6.6) and broad applicability can therefore be envisaged.

  14. Electrokinetic effects and fluid permeability

    International Nuclear Information System (INIS)

    Berryman, J.G.

    2003-01-01

    Fluid permeability of porous media depends mainly on connectivity of the pore space and two physical parameters: porosity and a pertinent length-scale parameter. Electrical imaging methods typically establish connectivity and directly measure electrical conductivity, which can then often be related to porosity by Archie's law. When electrical phase measurements are made in addition to the amplitude measurements, information about the pertinent length scale can then be obtained. Since fluid permeability controls the ability to flush unwanted fluid contaminants from the subsurface, inexpensive maps of permeability could improve planning strategies for remediation efforts. Detailed knowledge of fluid permeability is also important for oil field exploitation, where knowledge of permeability distribution in three dimensions is a common requirement for petroleum reservoir simulation and analysis, as well as for estimates on the economics of recovery

  15. Multidomain multiphase fluid mechanics

    International Nuclear Information System (INIS)

    Sha, W.T.; Soo, S.L.

    1976-10-01

    A set of multiphase field equations--conversion of mass, momentum and energy--based on multiphase mechanics is developed. Multiphase mechanics applies to mixtures of phases which are separated by interfaces and are mutually exclusive. Based on the multiphase mechanics formulation, additional terms appear in the field equations when the physical size of the dispersed phase (bubble or droplet) is many times larger than the inter-molecular spacing. These terms are the inertial coupling due to virtual mass and the additional viscous coupling due to unsteadiness of the flow field. The multiphase formulation given here takes into account the discreteness of particles of dispersed phases and, at the same time, the necessity of the distributive representation of field variables via space-time averaging when handling a large number of particles. The provision for multidomain transition further permits us to treat dispersed phases which are large compared to the characteristic dimension of the flow system via interdomain relations. The multidomain multiphase approach provides a framework for us to model the various flow regimes. Because some of the transport parameters associated with the system equations are not well known at the present time, an idealized two-domain two-phase solution approach is proposed as a first step. Finally, comparisons are made between the field equations formulated based on the multidomain-multiphase fluid mechanics and the pertinent existing models, and their relative significances are discussed. The desirability of consistent approximation and simplifications possible for dilute suspensions are discussed

  16. Turbine lubrication fluid varnish mitigation

    Energy Technology Data Exchange (ETDEWEB)

    Farooq, Khalid [Pall Corporation, Port Washington, NY (United States)

    2010-04-15

    Varnish deposits on internal surfaces in turbine lube systems result in a number of adverse operational issues, especially the restriction and sticking of the moving parts of servo- or directional control valves, resulting in their malfunction. The lubrication fluid has limited solvency for the varnish-forming material, hence a typical turbine will have the majority of this material as deposits and a relatively small portion as suspension in the fluid phase, in quasi-equilibrium with the deposits. The lube system needs to be cleaned by removing the suspended varnish-forming material from the fluid phase, which allows the deposits to re-entrain into the fluid phase, until the majority of the transferable deposits are removed and the fluid carries no significant amount of the material to have any adverse effect. The methods used for the removal of varnish from turbine lube systems include chemical cleaning/flushing, electrostatic charge induced agglomeration/retention, and the adsorption of the varnish suspended in the oil on an adsorbent medium. The paper discusses an absorption-based removal method that utilizes a fibrous medium that has pronounced affinity for the removal and retention of the varnish-forming material from the fluid as well as the deposits from surfaces that are in quasi-equilibrium with the varnish precursors in the fluid. The filtration medium is a composite, made with cellulose bonded by specially formulated, temperature-cured resins. The absorptive medium exhibits high structural and chemical integrity and has been thoroughly tested on operating turbines, showing reduction in varnish levels from the critical range to below normal range in a relatively short time. The experience with the utilization of the absorptive medium in laboratory tests and in two operating turbines is presented. (orig.)

  17. Gyroelastic fluids

    Energy Technology Data Exchange (ETDEWEB)

    Kerbel, G.D.

    1981-01-20

    A study is made of a scale model in three dimensions of a guiding center plasma within the purview of gyroelastic (also known as finite gyroradius-near theta pinch) magnetohydrodynamics. The (nonlinear) system sustains a particular symmetry called isorrhopy which permits the decoupling of fluid modes from drift modes. Isorrhopic equilibria are analyzed within the framework of geometrical optics resulting in (local) dispersion relations and ray constants. A general scheme is developed to evolve an arbitrary linear perturbation of a screwpinch equilibrium as an invertible integral transform (over the complete set of generalized eigenfunctions defined naturally by the equilibrium). Details of the structure of the function space and the associated spectra are elucidated. Features of the (global) dispersion relation owing to the presence of gyroelastic stabilization are revealed. An energy principle is developed to study the stability of the tubular screwpinch.

  18. Gyroelastic fluids

    International Nuclear Information System (INIS)

    Kerbel, G.D.

    1981-01-01

    A study is made of a scale model in three dimensions of a guiding center plasma within the purview of gyroelastic (also known as finite gyroradius-near theta pinch) magnetohydrodynamics. The (nonlinear) system sustains a particular symmetry called isorrhopy which permits the decoupling of fluid modes from drift modes. Isorrhopic equilibria are analyzed within the framework of geometrical optics resulting in (local) dispersion relations and ray constants. A general scheme is developed to evolve an arbitrary linear perturbation of a screwpinch equilibrium as an invertible integral transform (over the complete set of generalized eigenfunctions defined naturally by the equilibrium). Details of the structure of the function space and the associated spectra are elucidated. Features of the (global) dispersion relation owing to the presence of gyroelastic stabilization are revealed. An energy principle is developed to study the stability of the tubular screwpinch

  19. Surfactant-coated graphitized multiwalled carbon nanotubes as the pseudostationary phase in electrokinetic chromatography for the analysis of phytochemical compounds in biological fluids.

    Science.gov (United States)

    Cao, Wan; Hu, Shuai-Shuai; Ying, Xue-Zhen; Ye, Li-Hong; Cao, Jun

    2015-04-01

    This report describes the use of surfactant-coated graphitized multiwalled carbon nanotubes (SC-GMWNTs) as a novel pseudostationary phase in CE with diode array detection for the determination of phenolic acids and tanshinones in herbal and urine samples. Several parameters influencing the separation were studied, such as the concentrations of SDS, GMWNTs, and isopropanol; choice of carbon nanotubes; sodium borate content; and buffer pH. The results revealed that the presence of SC-GMWNTs in buffer enhanced the separation efficiency for the target analytes relative to conventional micelles due to the strong interaction between the surface of the GMWNTs and the target compounds. Under the optimum conditions, the method showed good linearity, with correlation coefficients higher than 0.9950. LODs were in the range of 0.71-3.10 μg/mL. Furthermore, satisfactory separations were achieved with good recovery values in the range of 89.97 and 103.30% when 10 mM borate, 30 mM SDS, 10% isopropanol, and 6 μg/mL SC-GMWNTs were introduced into the buffer solution. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Three-dimensional multi-phase flow computational fluid dynamics model for analysis of transport phenomena and thermal stresses in PEM fuel cells

    Energy Technology Data Exchange (ETDEWEB)

    Maher, A.R.; Al-Baghdadi, S. [International Technological Univ., London (United Kingdom). Dept. of Mechanical Engineering; Haroun, A.K.; Al-Janabi, S. [Babylon Univ., Babylon (Iraq). Dept. of Mechanical Engineering

    2007-07-01

    Fuel cell technology is expected to play an important role in meeting the growing demand for distributed generation because it can convert the chemical energy of a clean fuel directly into electrical energy. An operating fuel cell has varying local conditions of temperature, humidity, and power generation across the active area of the fuel cell in 3D. This paper presented a model that was developed to improve the basic understanding of the transport phenomena and thermal stresses in PEM fuel cells, and to investigate the behaviour of polymer membrane under hygro and thermal stresses during the cell operation. This comprehensive 3D, multiphase, non-isothermal model accounts for the major transport phenomena in a PEM fuel cell, notably convective and diffusive heat and mass transfer; electrode kinetics; transport and phase change mechanism of water; and potential fields. The model accounts for the liquid water flux inside the gas diffusion layers by viscous and capillary forces and can therefore predict the amount of liquid water inside the gas diffusion layers. This study also investigated the key parameters affecting fuel cell performance including geometry, materials and operating conditions. The model considers the many interacting, complex electrochemical, transport phenomena, thermal stresses and deformation that cannot be studied experimentally. It was concluded that the model can provide a computer-aided tool for the design and optimization of future fuel cells with much higher power density and lower cost. 21 refs., 2 tabs., 14 figs.

  1. In situ production of titanium dioxide nanoparticles in molten salt phase for thermal energy storage and heat-transfer fluid applications

    Energy Technology Data Exchange (ETDEWEB)

    Lasfargues, Mathieu, E-mail: m.lasfargues@outlook.com; Bell, Andrew, E-mail: A.bell@leeds.ac.uk [University of Leeds, School of Chemical and Process Engineering (United Kingdom); Ding, Yulong, E-mail: y.ding@bham.ac.uk [University of Birmingham, School of Chemical Engineering (United Kingdom)

    2016-06-15

    In this study, TiO{sub 2} nanoparticles (average particle size 16 nm) were successfully produced in molten salt phase and were showed to significantly enhance the specific heat capacity of a binary eutectic mixture of sodium and potassium nitrate (60/40) by 5.4 % at 390 °C and 7.5 % at 445 °C for 3.0 wt% of precursors used. The objective of this research was to develop a cost-effective alternate method of production which is potentially scalable, as current techniques utilized are not economically viable for large quantities. Enhancing the specific heat capacity of molten salt would promote more competitive pricing for electricity production by concentrating solar power plant. Here, a simple precursor (TiOSO{sub 4}) was added to a binary eutectic mixture of potassium and sodium nitrate, heated to 450 °C, and cooled to witness the production of nanoparticles.

  2. Mixed hemimicelles solid-phase extraction based on sodium dodecyl sulfate (SDS)-coated nano-magnets for the spectrophotometric determination of Fingolomid in biological fluids

    Science.gov (United States)

    Azari, Zhila; Pourbasheer, Eslam; Beheshti, Abolghasem

    2016-01-01

    In this study, mixed hemimicelles solid-phase extraction (SPE) based on sodium dodecyl sulfate (SDS)-coated nano-magnets Fe3O4 was investigated as a novel method for the separation and determination of Fingolimod (FLM) in water, urine and plasma samples prior to spectrophotometeric determination. Due to the high surface area of these new sorbents and the excellent adsorption capacity after surface modification by SDS, satisfactory extraction recoveries can be produced. The main factors affecting the adsolubilization of analysts, such as pH, surfactant and adsorbent amounts, ionic strength, extraction time and desorption conditions were studied and optimized. Under the selected conditions, FLM has been quantitatively extracted. The accuracy of the method was evaluated by recovery measurements on spiked samples, and good recoveries of 96%, 95% and 88% were observed for water, urine and plasma respectively. Proper linear behaviors over the investigated concentration ranges of 2-26, 2-17 and 2-13 mg/L with good coefficients of determination, 0.998, 0.997 and 0.995 were achieved for water, urine and plasma samples, respectively. To the best of our knowledge, this is the first time that a mixed hemimicelles SPE method based on magnetic separation and nanoparticles has been used as a simple and sensitive method for monitoring of FLM in water and biological samples.

  3. On the constitutive laws of 1-D, two-fluid, two-phase flow models: possible mathematical forms, restrictions resulting from basic principles

    International Nuclear Information System (INIS)

    Boure, J.A.

    1981-01-01

    From both the theoretical and the practical points of view, the problem of constitutive laws is part and parcel of the modeling problem. In particular, the necessity to restore in the model, through topological laws, some of the information lost during the usual averaging process is emphasized. A new void fraction topological law is proposed. The limitations of the current assumption of uniform pressure within each phase in any cross section are also illustrated. The importance of proximity effects (neighborhood and history effects, related to characteristic lengths and times) is brought out. It results in the importance of the mathematical form of the constitutive laws. Possible mathematical forms for the transfer laws are reviewed. The last part of the paper is devoted to some restrictions, which are imposed on the transfer terms because of some basic principles: Indifference to Galilean changes of frame and to some changes of origins, second law of thermodynamics and hypothesis of local thermodynamic equilibrium, closure constraints. Practical recommendations are formulated

  4. In situ production of titanium dioxide nanoparticles in molten salt phase for thermal energy storage and heat-transfer fluid applications

    International Nuclear Information System (INIS)

    Lasfargues, Mathieu; Bell, Andrew; Ding, Yulong

    2016-01-01

    In this study, TiO_2 nanoparticles (average particle size 16 nm) were successfully produced in molten salt phase and were showed to significantly enhance the specific heat capacity of a binary eutectic mixture of sodium and potassium nitrate (60/40) by 5.4 % at 390 °C and 7.5 % at 445 °C for 3.0 wt% of precursors used. The objective of this research was to develop a cost-effective alternate method of production which is potentially scalable, as current techniques utilized are not economically viable for large quantities. Enhancing the specific heat capacity of molten salt would promote more competitive pricing for electricity production by concentrating solar power plant. Here, a simple precursor (TiOSO_4) was added to a binary eutectic mixture of potassium and sodium nitrate, heated to 450 °C, and cooled to witness the production of nanoparticles.

  5. The constitutive laws of one-dimensional, two-fluid models for two-phase flows - Possible mathematical forms - Restrictions resulting from basic principles

    International Nuclear Information System (INIS)

    Boure, Jean.

    1978-05-01

    From both the theoretical and the practical points of view, the problem of constitutive laws is a part and parcel of the modeling problem. In particular, the necessity to restore in the model, through topological laws, some of the information lost during the usual averaging process is emphasized. It is shown that the customary 'void fraction' topological law Psub(V)=Psub(L) should be proscribed whenever propagation phenomena are involved. A new void fraction topological law is proposed. The limitations of the current assumption of constant pressure within any phase in any cross section are also illustrated. The importance of proximity effects (neighborhood and history effects, related to characteristic lengths and times) is brought out. It results in the importance of the mathematical form of the constitutive laws. Various approaches to the constitutive law problem and possible mathematical forms for the transfer laws are reviewed. The simplest form (transfert terms as functions of the dependent variables only) may have some usefulness if interpretation of the results in terms of propagation phenomena is banned. A good compromise between the necessity to take proximity effects into account and to obtain a tractable set of equations is carried out when so called 'differential terms' are introduced in the transfer laws. The last part of the paper is devoted to some restrictions, which are imposed to the transfer terms because of some basic principles: indifference to Galilean changes of frame and to some changes of origins, second law of thermodynamics and assumption of local thermodynamic equilibrium, closure constraints. Practical recommendations are formulated [fr

  6. Polypyrrole/magnetic nanoparticles composite as an efficient sorbent for dispersive micro-solid-phase extraction of antidepressant drugs from biological fluids.

    Science.gov (United States)

    Asgharinezhad, Ali Akbar; Karami, Sara; Ebrahimzadeh, Homeira; Shekari, Nafiseh; Jalilian, Niloofar

    2015-10-15

    In this study, polypyrrole/magnetic nanoparticles composites in the presence of two different dopants were synthesized with the aid of chemical oxidative polymerization process for dispersive-μ-solid phase extraction (D-μ-SPE). The synthesized magnetic sorbents were characterized by various techniques. The results exhibited that the nanocomposite modified by polypyrrole with sodium perchlorate as a dopant demonstrated higher extraction efficiency for citalopram (CIT) and sertraline (STR) as the model compounds. This nanosorbent in combination with high performance liquid chromatography-UV detection was applied for extraction, preconcentration and determination of CIT and STR in urine and plasma samples. The effect of various parameters on the extraction efficiency including: sample pH, amount of sorbent, sorption time, eluent and its volume, salt content, and elution time were investigated and optimized. The opted conditions were: sample pH, 9.0; sorbent dosage, 10mg; sorption time, 7 min; elution solvent and its volume, 0.06 mol L(-1) HCl in methanol, 120 μL; elution time, 2 min and without addition of salt to the sample. The calibration curves were linear in the concentration range of 1-800 μg L(-1). The limits of detection (LODs) were obtained in the range of 0.2-1.0 μg L(-1) for CIT and 0.3-0.7 μg L(-1) for STR, respectively. The percent of extraction recoveries and relative standard deviations (n=5) were in the range of 93.4-99, 4.8-8.4 for CIT and 94-98.4, 4.3-9.2 for STR, respectively. Finally, the applicability of the method was successfully confirmed by the extraction and determination of CIT and STR in human urine and plasma samples. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. Supercritical fluids technology. Pt. 1 General topics

    International Nuclear Information System (INIS)

    Marongiu, B.; De Giorgi, M. R.; Porcedda, S.; Cadoni, E.

    1998-01-01

    Supercritical fluids technology is among the emerging 'clean' technologies, that allows the minimization in the use of chemical and thermic treatments and products irradiation, diminishing the quantity of liquid wastes to be treated. In this first article phase equilibria thermodynamics and fluid mechanics of transport phenomena are reviewed [it

  8. Magnetic nanoparticles based dispersive micro-solid-phase extraction as a novel technique for coextraction of acidic and basic drugs from biological fluids and waste water.

    Science.gov (United States)

    Asgharinezhad, Ali Akbar; Mollazadeh, Narges; Ebrahimzadeh, Homeira; Mirbabaei, Fatemeh; Shekari, Nafiseh

    2014-04-18

    The coextraction of acidic and basic drugs from different samples is a considerable and disputable concept in sample preparation strategies. In this study, for the first time, simultaneous extraction of acidic and basic drugs with magnetic nanoparticles based dispersive micro-solid phase extraction followed by high performance liquid chromatography-ultraviolet detection was introduced. Cetyltrimethyl ammonium bromide-coated Fe3O4@decanoic acid as an efficient sorbent was successfully applied to adsorb diclofenac (DIC) as an acidic and diphenhydramine (DPH) as a basic model compound. First, appropriate amount of synthetic Fe3O4@decanoic acid nanoparticles was added to aqueous solution of drugs. After adjusting the pH of the solution, cetyltrimethyl ammonium bromide (CTAB) was added to the mixture being stirred at a constant rate. After the adsorption of drugs and decantation of supernatant with a magnetic field, the sorbent was eluted with methanol by fierce vortex. The parameters affecting the extraction efficiency were optimized and obtained as: pH of the sample=9, concentration of CTAB=0.2mmolL(-1), amount of sorbent=10mg, extraction time=5min, no salt addition to sample, type and volume of the eluent=50μL methanol, and desorption time=1min. Under the optimum conditions detection limits and linear dynamic ranges were achieved in the range of 1.8-3.0, 5-1500μgL(-1) for DPH and 1.5-3.5, 5-1500μgL(-1) for DIC, respectively. The percent of extraction recovery and relative standard deviations (n=5) were in the range of 47.3-60, 5.2-9.0 for DPH and 64-76.7, 5.1-5.8 for DIC, respectively. Ultimately, the applicability of the method was successfully confirmed by the extraction and determination of DIC and DPH in human urine, plasma and waste water samples in the range of microgram per liter and satisfactory results were obtained. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Standardization of Thermo-Fluid Modeling in Modelica.Fluid

    Energy Technology Data Exchange (ETDEWEB)

    Franke, Rudiger; Casella, Francesco; Sielemann, Michael; Proelss, Katrin; Otter, Martin; Wetter, Michael

    2009-09-01

    This article discusses the Modelica.Fluid library that has been included in the Modelica Standard Library 3.1. Modelica.Fluid provides interfaces and basic components for the device-oriented modeling of onedimensional thermo-fluid flow in networks containing vessels, pipes, fluid machines, valves and fittings. A unique feature of Modelica.Fluid is that the component equations and the media models as well as pressure loss and heat transfer correlations are decoupled from each other. All components are implemented such that they can be used for media from the Modelica.Media library. This means that an incompressible or compressible medium, a single or a multiple substance medium with one or more phases might be used with one and the same model as long as the modeling assumptions made hold. Furthermore, trace substances are supported. Modeling assumptions can be configured globally in an outer System object. This covers in particular the initialization, uni- or bi-directional flow, and dynamic or steady-state formulation of mass, energy, and momentum balance. All assumptions can be locally refined for every component. While Modelica.Fluid contains a reasonable set of component models, the goal of the library is not to provide a comprehensive set of models, but rather to provide interfaces and best practices for the treatment of issues such as connector design and implementation of energy, mass and momentum balances. Applications from various domains are presented.

  10. Development of an achiral supercritical fluid chromatography method with ultraviolet absorbance and mass spectrometric detection for impurity profiling of drug candidates. Part II. Selection of an orthogonal set of stationary phases.

    Science.gov (United States)

    Lemasson, Elise; Bertin, Sophie; Hennig, Philippe; Boiteux, Hélène; Lesellier, Eric; West, Caroline

    2015-08-21

    Impurity profiling of organic products that are synthesized as possible drug candidates requires complementary analytical methods to ensure that all impurities are identified. Supercritical fluid chromatography (SFC) is a very useful tool to achieve this objective, as an adequate selection of stationary phases can provide orthogonal separations so as to maximize the chances to see all impurities. In this series of papers, we have developed a method for achiral SFC-MS profiling of drug candidates, based on a selection of 160 analytes issued from Servier Research Laboratories. In the first part of this study, focusing on mobile phase selection, a gradient elution with carbon dioxide and methanol comprising 2% water and 20mM ammonium acetate proved to be the best in terms of chromatographic performance, while also providing good MS response [1]. The objective of this second part was the selection of an orthogonal set of ultra-high performance stationary phases, that was carried out in two steps. Firstly, a reduced set of analytes (20) was used to screen 23 columns. The columns selected were all 1.7-2.5μm fully porous or 2.6-2.7μm superficially porous particles, with a variety of stationary phase chemistries. Derringer desirability functions were used to rank the columns according to retention window, column efficiency evaluated with peak width of selected analytes, and the proportion of analytes successfully eluted with good peak shapes. The columns providing the worst performances were thus eliminated and a shorter selection of columns (11) was obtained. Secondly, based on 160 tested analytes, the 11 columns were ranked again. The retention data obtained on these columns were then compared to define a reduced set of the best columns providing the greatest orthogonality, to maximize the chances to see all impurities within a limited number of runs. Two high-performance columns were thus selected: ACQUITY UPC(2) HSS C18 SB and Nucleoshell HILIC. Copyright © 2015

  11. Analysis of Odorants in Marking Fluid of Siberian Tiger (Panthera tigris altaica) Using Simultaneous Sensory and Chemical Analysis with Headspace Solid-Phase Microextraction and Multidimensional Gas Chromatography-Mass Spectrometry-Olfactometry.

    Science.gov (United States)

    Soso, Simone B; Koziel, Jacek A

    2016-06-25

    Scent-marking is the most effective method of communication in the presence or absence of a signaler. These complex mixtures result in a multifaceted interaction triggered by the sense of smell. The objective was to identify volatile organic compound (VOC) composition and odors emitted by total marking fluid (MF) associated with Siberian tigers (Panthera tigris altaica). Siberian tiger, an endangered species, was chosen because its MF had never been analyzed. Solid phase microextraction (SPME) for headspace volatile collection combined with multidimensional gas chromatography-mass spectrometry-olfactometry for simultaneous chemical and sensory analyses were used. Thirty-two VOCs emitted from MF were identified. 2-acetyl-1-pyrroline, the sole previously identified compound responsible for the "characteristic" odor of P. tigris MF, was identified along with two additional compounds confirmed with standards (urea, furfural) and four tentatively identified compounds (3-methylbutanamine, (R)-3-methylcyclopentanone, propanedioic acid, and 3-hydroxybutanal) as being responsible for the characteristic aroma of Siberian tiger MF. Simultaneous chemical and sensory analyses improved characterization of scent-markings and identified compounds not previously reported in MF of other tiger species. This research will assist animal ecologists, behaviorists, and zookeepers in understanding how scents from specific MF compounds impact tiger and wildlife communication and improve management practices related to animal behavior. Simultaneous chemical and sensory analyses is applicable to unlocking scent-marking information for other species.

  12. Analysis of Odorants in Marking Fluid of Siberian Tiger (Panthera tigris altaica Using Simultaneous Sensory and Chemical Analysis with Headspace Solid-Phase Microextraction and Multidimensional Gas Chromatography-Mass Spectrometry-Olfactometry

    Directory of Open Access Journals (Sweden)

    Simone B. Soso

    2016-06-01

    Full Text Available Scent-marking is the most effective method of communication in the presence or absence of a signaler. These complex mixtures result in a multifaceted interaction triggered by the sense of smell. The objective was to identify volatile organic compound (VOC composition and odors emitted by total marking fluid (MF associated with Siberian tigers (Panthera tigris altaica. Siberian tiger, an endangered species, was chosen because its MF had never been analyzed. Solid phase microextraction (SPME for headspace volatile collection combined with multidimensional gas chromatography-mass spectrometry-olfactometry for simultaneous chemical and sensory analyses were used. Thirty-two VOCs emitted from MF were identified. 2-acetyl-1-pyrroline, the sole previously identified compound responsible for the “characteristic” odor of P. tigris MF, was identified along with two additional compounds confirmed with standards (urea, furfural and four tentatively identified compounds (3-methylbutanamine, (R-3-methylcyclopentanone, propanedioic acid, and 3-hydroxybutanal as being responsible for the characteristic aroma of Siberian tiger MF. Simultaneous chemical and sensory analyses improved characterization of scent-markings and identified compounds not previously reported in MF of other tiger species. This research will assist animal ecologists, behaviorists, and zookeepers in understanding how scents from specific MF compounds impact tiger and wildlife communication and improve management practices related to animal behavior. Simultaneous chemical and sensory analyses is applicable to unlocking scent-marking information for other species.

  13. A microsphere suspension model of metamaterial fluids

    Directory of Open Access Journals (Sweden)

    Qian Duan

    2017-05-01

    Full Text Available Drawing an analogy to the liquid phase of natural materials, we theoretically propose a microsphere suspension model to realize a metamaterial fluid with artificial electromagnetic indexes. By immersing high-ε, micrometer-sized dielectric spheres in a low-ε insulating oil, the structured fluid exhibits liquid-like properties from dispersing phase as well as the isotropic negative electromagnetic parameters caused by Mie resonances from dispersed microspheres. The work presented here will benefit the development of structured fluids toward metamaterials.

  14. Synovial fluid analysis

    Science.gov (United States)

    Joint fluid analysis; Joint fluid aspiration ... El-Gabalawy HS. Synovial fluid analysis, synovial biopsy, and synovial pathology. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelly's Textbook of ...

  15. Self lubricating fluid bearings

    International Nuclear Information System (INIS)

    Kapich, D.D.

    1980-01-01

    The invention concerns self lubricating fluid bearings, which are used in a shaft sealed system extending two regions. These regions contain fluids, which have to be isolated. A first seal is fluid tight for the first region between the carter shaft and the shaft. The second seal is fluid tight between the carter and the shaft, it communicates with the second region. The first fluid region is the environment surrounding the shaft carter. The second fluid region is a part of a nuclear reactor which contains the cooling fluid. The shaft is conceived to drive a reactor circulating and cooling fluid [fr

  16. Modern fluid dynamics

    CERN Document Server

    Kleinstreuer, Clement

    2018-01-01

    Modern Fluid Dynamics, Second Edition provides up-to-date coverage of intermediate and advanced fluids topics. The text emphasizes fundamentals and applications, supported by worked examples and case studies. Scale analysis, non-Newtonian fluid flow, surface coating, convection heat transfer, lubrication, fluid-particle dynamics, microfluidics, entropy generation, and fluid-structure interactions are among the topics covered. Part A presents fluids principles, and prepares readers for the applications of fluid dynamics covered in Part B, which includes computer simulations and project writing. A review of the engineering math needed for fluid dynamics is included in an appendix.

  17. Ultrasonic techniques for fluids characterization

    CERN Document Server

    Povey, Malcolm J W

    1997-01-01

    This book is a comprehensive and practical guide to the use of ultrasonic techniques for the characterization of fluids. Focusing on ultrasonic velocimetry, the author covers the basic topics and techniques necessaryfor successful ultrasound measurements on emulsions, dispersions, multiphase media, and viscoelastic/viscoplastic materials. Advanced techniques such as scattering, particle sizing, and automation are also presented. As a handbook for industrial and scientific use, Ultrasonic Techniques for Fluids Characterization is an indispensable guide to chemists and chemical engineers using ultrasound for research or process monitoring in the chemical, food processing, pharmaceutical, cosmetic, biotechnology,and fuels industries. Key Features * Appeals to anyone using ultrasound to study fluids * Provides the first detailed description of the ultrasound profiling technique for dispersions * Describes new techniques for measuring phase transitions and nucleation, such as water/ice and oil/fat * Presents the l...

  18. Advanced Heat Transfer Fluids, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Future NASA instrumentation will requir