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Sample records for flip angle gradient

  1. Magnetic resonance imaging of lumbar spine. Comparison of multiple spin echo and low flip angle gradient echo imaging

    Energy Technology Data Exchange (ETDEWEB)

    Murakami, Takamichi; Fujita, Norihiko; Harada, Koushi; Kozuka, Takahiro (Osaka Univ. (Japan). Faculty of Medicine)

    1989-07-01

    Sixteen patients including 13 cases with disk herniation and 3 cases with spondylosis of lumbar spine were examined on a resistive MRI system operating at 0.1 T. All lesions were studied with both multiple spin echo (MSE) and low flip angle gradient echo (LF) techniques to evaluate which technique is more effective in detecting the disk degeneration and the indentation on subarachnoid space. MSE images were obtained with repetition time (TR) of 1100-1500 ms or cardiac gating, an echo time (TE) of 30, 60, 90, 120, 150, and 180 ms symmetrical 6 echoes, and total acquisition time of more than 281 sec. LF images were obtained with TR of 500, 250, and 100 ms, TE of 18 ms, a flip angle of 30 degree, and total acquisition time of 128 sec. Eleven lesions of spinal disk degeneration and 12 of indentation on subarachnoid space were detected with LF. On the other hand, 26 lesions of spinal disk degeneration and 38 of indentation on subarachnoid space were detected with MSE. Although the parameters of LF employed in this study were relatively effective to emphasize T2{sup *}-based contrast, the ability of LF in detection of spinal disk degeneration and indentation on subarachnoid space is less than that of MSE. Signal contrast to noise ratios for normal disk and degenerative disk, epidural-fat and disk herniated material, CSF and disk herniated material, and epidural-fat and CSF were less than 4 with LF, but more than 4 with MSE. This difference of contrast to noise ratio between MSE and LF was one of the main causes of the difference of the detection rate of spinal disk degeneration and indentation on subarachnoid space. (author).

  2. Mapping of low flip angles in magnetic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Balezeau, Fabien; Saint-Jalmes, Herve [LTSI, INSERM U642, Universite Rennes 1 (France); Eliat, Pierre-Antoine [PRISM, IFR 140, Universite Rennes 1 (France); Cayamo, Alejandro Bordelois, E-mail: fabien.balezeau@gmail.com [Centro De BiofIsika Medica, Universidad de Oriente, Santiago de Cuba (Cuba)

    2011-10-21

    Errors in the flip angle have to be corrected in many magnetic resonance imaging applications, especially for T1 quantification. However, the existing methods of B1 mapping fail to measure lower values of the flip angle despite the fact that these are extensively used in dynamic acquisition and 3D imaging. In this study, the nonlinearity of the radiofrequency (RF) transmit chain, especially for very low flip angles, is investigated and a simple method is proposed to accurately determine both the gain of the RF transmitter and the B1 field map for low flip angles. The method makes use of the spoiled gradient echo sequence with long repetition time (TR), such as applied in the double-angle method. It uses an image acquired with a flip angle of 90{sup 0} as a reference image that is robust to B1 inhomogeneity. The ratio of the image at flip angle alpha to the image at a flip angle of 90{sup 0} enables us to calculate the actual value of alpha. This study was carried out at 1.5 and 4.7 T, showing that the linearity of the RF supply system is highly dependent on the hardware. The method proposed here allows us to measure the flip angle from 1{sup 0} to 60{sup 0} with a maximal uncertainty of 10% and to correct T1 maps based on the variable flip angle method.

  3. Gradient Descent Bit Flipping Algorithms for Decoding LDPC Codes

    OpenAIRE

    Wadayama, Tadashi; Nakamura, Keisuke; Yagita, Masayuki; Funahashi, Yuuki; Usami, Shogo; Takumi, Ichi

    2007-01-01

    A novel class of bit-flipping (BF) algorithms for decoding low-density parity-check (LDPC) codes is presented. The proposed algorithms, which are called gradient descent bit flipping (GDBF) algorithms, can be regarded as simplified gradient descent algorithms. Based on gradient descent formulation, the proposed algorithms are naturally derived from a simple non-linear objective function.

  4. Variable-flip-angle single-slab 3D GRASE imaging with phase-independent image reconstruction.

    Science.gov (United States)

    Kim, Hahnsung; Kim, Dong-Hyun; Park, Jaeseok

    2015-03-01

    To develop a single-slab three-dimensional variable-flip-angle gradient- and spin-echo pulse sequence with phase-independent reconstruction that is highly energy- or encoding-efficient for high resolution isotropic imaging at high magnetic field. Amplitude modulation in the proposed pulse sequence was alleviated using a variable-flip-angle induced smooth signal evolution along the long echo train. To avoid phase modulation, instead of directly interleaving phase encoding signals with different off-resonance induced phase accumulation over multiple echoes, phase-independent image reconstruction was performed, wherein each echo image was separately reconstructed using convolution-interpolation with echo-interleaving self-calibration and then combined. Numerical and experimental studies were performed at 3.0 T for generation of clinical T2 -weighted contrast to investigate the effectiveness of the proposed method over existing methods. Compared with conventional techniques, the proposed method produces smooth amplitude variation, no ghosting artifacts (no phase modulation), and competitive signal-to-noise ratio. An energy-efficient variable-flip-angle gradient- and spin-echo reduces specific absorption rate by 71% without significant loss of signal-to-noise ratio, while an encoding-efficient one decreases imaging time by 54% with a slight loss of signal-to-noise ratio. We successfully demonstrated that the proposed variable-flip-angle gradient- and spin-echo can be a highly promising energy- or encoding-efficient alternative for high resolution isotropic imaging. © 2014 Wiley Periodicals, Inc.

  5. Tailored RF Pulse Modulation for RF Refocussed Variable Flip Angle MRI

    Science.gov (United States)

    Shah, Ajit S.; Ortendahl, Douglas A.; Carlson, Joseph W.; Kramer, David M.; Crooks, Larry E.

    1989-05-01

    Advances in Magnetice Resonance Imaging (MRI) techniques have recently made MRI the imaging modality of choice for many applications of clinical imaging. MRI provides the diagnosing clinician a non-invasive method for obtaining soft tissue differentiation with sub-millimeter resolution. Clinical MRI techniques include 3-dimensional imaging, spectroscopic imaging, arterial angiography and cardiac imaging. One MRI technique which has recently gained popularity is a class of protocols known as variable/partial flip angle MRI. Partial flip angle MRI techniques are useful because of their ability to vary contrast between tissues and/or maintain a particular level of contrast with a reduction in acquisition time [1]. Variable flip angle techniques differ from conventional MRI protocols in that the initial RF excitation/rotation pulse is not constrained to a 90 degree rotation of the longitudinal magnetization. Instead, the initial excitation flip angle is calculated to provide improved contrast between two tissues and/or maximize the intensity of a particular tissue. For tissues with reduced TR/T1 ratios, variable flip angle techniques may also be used to increase the image signal to noise within a localized region.

  6. DCE-PWI 3D T1-measurement as function of time or flip angle

    DEFF Research Database (Denmark)

    Mikkelsen, Irene Klærke; Peters, David Alberg; Tietze, Anna

    Dynamic Contrast Enhanced Perfusion Weighted Imaging (DCE-PWI) and the preceding T1 measurement is usually performed with a FLASH sequence. For the sake of speed, the 3D T1 measurement is often performed by measuring the signal for a range of flip angles instead of as a function the inversion (or...

  7. Broadband RF-amplitude-dependent flip angle pulses with linear phase slope.

    Science.gov (United States)

    Koos, Martin R M; Feyrer, Hannes; Luy, Burkhard

    2017-09-01

    Pulse sequences in NMR spectroscopy sometimes require the application of pulses with effective flip angles different from 90° and 180°. Previously (Magn. Reson. Chem. 2015, 53, 886-893), offset-compensated broadband excitation pulses with RF-amplitude-dependent effective flip angles (RADFA) were introduced that are applicable in such cases. However, especially RF-amplitude-restricted RADFA pulses turned out to perform not as good as desired in terms of achievable bandwidths. Here, a class of RF-amplitude-restricted RADFA pulses with linear phase slope is introduced that allows excitation over much larger bandwidths with better performance. In this theoretical work, the basic principle of the pulse class is explained, their physical limits explored, and their properties, also compared with other pulse classes, discussed in detail. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  8. Scattering-angle based filtering of the waveform inversion gradients

    KAUST Repository

    Alkhalifah, Tariq Ali

    2014-11-22

    Full waveform inversion (FWI) requires a hierarchical approach to maneuver the complex non-linearity associated with the problem of velocity update. In anisotropic media, the non-linearity becomes far more complex with the potential trade-off between the multiparameter description of the model. A gradient filter helps us in accessing the parts of the gradient that are suitable to combat the potential non-linearity and parameter trade-off. The filter is based on representing the gradient in the time-lag normalized domain, in which the low scattering angle of the gradient update is initially muted out in the FWI implementation, in what we may refer to as a scattering angle continuation process. The result is a low wavelength update dominated by the transmission part of the update gradient. In this case, even 10 Hz data can produce vertically near-zero wavenumber updates suitable for a background correction of the model. Relaxing the filtering at a later stage in the FWI implementation allows for smaller scattering angles to contribute higher-resolution information to the model. The benefits of the extended domain based filtering of the gradient is not only it\\'s ability in providing low wavenumber gradients guided by the scattering angle, but also in its potential to provide gradients free of unphysical energy that may correspond to unrealistic scattering angles.

  9. Rapid spin-lattice relaxation time mapping incorporating flip angle calibration in quantitative magnetic resonance imaging

    Institute of Scientific and Technical Information of China (English)

    Zhongliang Zu; Qi Liu; Yanming Yu; Song Gao; Shanglian Bao

    2008-01-01

    Driven equilibrium single pulse observation of T1(DESPOT1)is a rapid spin-lattice relaxation constant(T1)mapping technique in magnetic resonance imaging(MRI).However,DESPOT1 is very sensitive to flip angle(FA)inhomogeneity,resulting in T1 inaccuracy.Here,a five-point DESPOTl method is proposed to reduce the sensitivity to FA inhomogeneity through FA measurement and calibra-tion.Phantom and in vivo experiments are performed to validate the technique.As a result.a rapid and accurate T1 mapping is acquired by using the proposed five-point DESPOT1 method.

  10. Task-based optimization of flip angle for texture analysis in MRI

    Science.gov (United States)

    Brand, Jonathan F.; Furenlid, Lars R.; Altbach, Maria I.; Galons, Jean-Phillippe; Bhattacharyya, Achyut; Sharma, Puneet; Bhattacharyya, Tulshi; Bilgin, Ali; Martin, Diego R.

    2016-03-01

    Chronic liver disease is a worldwide health problem, and hepatic fibrosis (HF) is one of the hallmarks of the disease. The current reference standard for diagnosing HF is biopsy followed by pathologist examination, however this is limited by sampling error and carries risk of complications. Pathology diagnosis of HF is based on textural change in the liver as a lobular collagen network that develops within portal triads. The scale of collagen lobules is characteristically on order of 1-5 mm, which approximates the resolution limit of in vivo gadolinium-enhanced magnetic resonance imaging in the delayed phase. We have shown that MRI of formalin fixed human ex vivo liver samples mimic the textural contrast of in vivo Gd-MRI and can be used as MRI phantoms. We have developed local texture analysis that is applied to phantom images, and the results are used to train model observers. The performance of the observer is assessed with the area-under-the-receiveroperator- characteristic curve (AUROC) as the figure of merit. To optimize the MRI pulse sequence, phantoms are scanned with multiple times at a range of flip angles. The flip angle that associated with the highest AUROC is chosen as optimal based on the task of detecting HF.

  11. Scattering angle base filtering of the inversion gradients

    KAUST Repository

    Alkhalifah, Tariq Ali

    2014-01-01

    Full waveform inversion (FWI) requires a hierarchical approach based on the availability of low frequencies to maneuver the complex nonlinearity associated with the problem of velocity inversion. I develop a model gradient filter to help us access the parts of the gradient more suitable to combat this potential nonlinearity. The filter is based on representing the gradient in the time-lag normalized domain, in which low scattering angles of the gradient update are initially muted. The result are long-wavelength updates controlled by the ray component of the wavefield. In this case, even 10 Hz data can produce near zero wavelength updates suitable for a background correction of the model. Allowing smaller scattering angle to contribute provides higher resolution information to the model.

  12. The effect of wok size and handle angle on the maximum acceptable weights of wok flipping by male cooks.

    Science.gov (United States)

    Wu, Swei-Pi; Ho, Cheng-Pin; Yen, Chin-Li

    2011-01-01

    A wok with a straight handle is one of the most common cooking utensils in the Asian kitchen. This common cooking instrument has seldom been examined by ergonomists. This research used a two-factor randomized complete block design to investigate the effects of wok size (with three diameters - 36 cm, 39 cm and 42 cm) and handle angle (25°, 10°, -5°, -20°, and -35°) on the task of flipping. The measurement criteria included the maximum acceptable weight of wok flipping (MAWF), the subjective rating and the subjective ranking. Twelve experienced males volunteered to take part in this study. The results showed that both the wok size and handle angle had a significant effect on the MAWF, the subjective rating and the subjective ranking. Additionally, there is a size-weight illusion associated with flipping tasks. In general, a small wok (36 cm diameter) with an ergonomically bent handle (-20° ± 15°) is the optimal design, for male cooks, for the purposes of flipping.

  13. Improved focal liver lesion detection by increasing flip angle during gadoxetic acid-enhancement in MRI

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Se Jy [Dept. of Medical science Graduate school, Chonnam National University, Kwangju (Korea, Republic of); Kim, Young Keun [Dept. of Radiotechnology, Gwang-ju Health university, Gwangju (Korea, Republic of)

    2015-06-15

    To study the differences of focal liver lesion image detection at 3 minute, 10 minute and 15 minute time points on gadoxetic acid (GA)’s enhanced MR imaging with a flip angle (FA) of 30° compared with a 11°. The subjects were 69 patients evaluated with GA enhanced MR imaging with 3.0T MR scanner. The patients are total 35(23 men and 7 women at the mean age of 60.4 years), hepatocellular carcinoma(23) and metastsis(12) except for normal, cyst and hemangioma. After GA was injected, FA 11° and 30° images were obtained at 3 minute, 10 minute and 15 minute time points respectively. After quantitative and qualitative assessment of each image was done, statistical analysis was performed by using the independent sample T-test. From both quantitative and qualitative assessment of 3 minute and 10 minute MR images after the injection of GA, FA 30° images was found to be superior than FA 11°, but there were no statistical significance. However, at 15 minute time point, Statistically significant FA 30° image(p<0.05) was better than FA 11° therefore, the FA 30° improves the focal liver lesion detection. FA 30° of MR image can detect liver lesion more sensitively than the existing FA11° image after GA contrast enhancement at 15 minute time point.

  14. 35Cl profiling using centric scan SPRITE with variable flip angle excitation

    Science.gov (United States)

    Romanenko, Konstantin V.; Cano-Barrita, P. F. de J.; Balcom, Bruce J.

    2009-05-01

    An efficient MRI technique for quantitative density profiling of samples with fast spin-lattice relaxation ( T1 technique. Strong excitation of the sample at the k-space origin improves the sensitivity with respect to the original centric scan SPRITE technique. Radio frequency pulse durations are defined so as to provide uniform excitation of the sample at every k-space point. For a particular k-space point the pulse duration is required to be less than the inverse sample bandwidth. Simulations permit one to examine distortions from ideal profile geometry due to flip angle and spin-lattice relaxation effects. The proposed technique is especially suitable for the observation of low sensitivity samples, in particular, low-γ nuclei like 35Cl. In some cases, this strategy permits one to reduce the number of scans, i.e. the experiment time, by a factor of 100, depending on hardware, sample length and tolerable resolution loss. The designed pulse scheme is tested on cylindrical agar gel and type 1 Portland cement paste phantoms prepared to provide 1H and 35Cl signals, respectively.

  15. Spontaneous changes in contact angle of water and oil on novel flip-flop-type hydrophobic multilayer coatings

    Science.gov (United States)

    Kawamura, Go; Ema, Tomoyuki; Sakamoto, Hisatoshi; Wei, Xing; Muto, Hiroyuki; Matsuda, Atsunori

    2014-04-01

    Multilayer structures composed of poly(allylamine hydrochloride) (PAH) and Nafion were fabricated on glass substrates by layer-by-layer assembly. Some of the multilayers demonstrated spontaneous changes in contact angle of water and oil due to flip-flop movements of free sulfo groups in the Nafion layer, and the multilayers eventually possessed water repellency in air and oil repellency in water. The repellencies were enhanced by applying primer layers that were formed using SiO2 fine particles to increase surface roughness. Compared to typical hydrophobic and oleophobic surfaces, the multilayers showed practical levels for a use as soil release coatings.

  16. Free-breathing variable flip angle balanced SSFP cardiac cine imaging with reduced SAR at 3T.

    Science.gov (United States)

    Srinivasan, Subashini; Kroeker, Randall M; Gabriel, Simon; Plotnik, Adam; Godinez, Sergio R; Hu, Peng; Halnon, Nancy; Finn, J Paul; Ennis, Daniel B

    2016-10-01

    To develop a free-breathing variable flip angle (VFA) balanced steady-state free precession (bSSFP) cardiac cine imaging technique with reduced specific absorption rate (SAR) at 3 Tesla. Free-breathing VFA (FB-VFA) images in the short-axis and four-chamber views were acquired using an optimal VFA scheme, then compared with conventional breath-hold constant flip angle (BH-CFA) acquisitions. Two cardiac MRI experts used a 5-point scale to score images from healthy subjects (N = 10). The left ventricular ejection fraction, end diastolic volume (LVEDV), end systolic volume, stroke volume (LVSV), and end diastolic myocardial mass (LVEDM) were determined by manual contour analysis for BH-CFA and FB-VFA. A pilot evaluation of FB-VFA was performed in one patient with Duchenne muscular dystrophy. FB-VFA SAR was 25% lower than BH-CFA with similar blood-myocardium contrast. The qualitative FB-VFA score was lower than the BH-CFA for the short-axis (3.1 ± 0.5 versus 4.3 ± 0.8; P cine imaging decreased the SAR at 3T with image quality sufficient to perform cardiac functional analysis. Magn Reson Med 76:1210-1216, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  17. Quantitative T1 and proton density mapping with direct calculation of radiofrequency coil transmit and receive profiles from two-point variable flip angle data.

    Science.gov (United States)

    Baudrexel, Simon; Reitz, Sarah C; Hof, Stephanie; Gracien, René-Maxime; Fleischer, Vinzenz; Zimmermann, Hilga; Droby, Amgad; Klein, Johannes C; Deichmann, Ralf

    2016-03-01

    Quantitative T1 mapping of brain tissue is frequently based on the variable flip angle (VFA) method, acquiring spoiled gradient echo (GE) datasets at different excitation angles. However, accurate T1 calculation requires a knowledge of the sensitivity profile B1 of the radiofrequency (RF) transmit coil. For an additional derivation of proton density (PD) maps, the receive coil sensitivity profile (RP) must also be known. Mapping of B1 and RP increases the experiment duration, which may be critical when investigating patients. In this work, a method is presented for the direct calculation of B1 and RP from VFA data. Thus, quantitative maps of T1 , PD, B1 and RP can be obtained from only two spoiled GE datasets. The method is based on: (1) the exploitation of the linear relationship between 1/PD and 1/T1 in brain tissue and (2) the assumption of smoothly varying B1 and RP, so that a large number of data points can be fitted across small volume elements where B1 and RP are approximately constant. The method is tested and optimized on healthy subjects. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  18. Characterization and flip angle calibration of 13C surface coils for hyperpolarization studies

    DEFF Research Database (Denmark)

    Hansen, Rie Beck; Gutte, Henrik; Larsen, Majbrit M E

    The aim of the present work is to address the challenge of optimal The aim of the present work is to address the challenge of optimal flflip angle calibration of ip angle calibration of C surface coils in C surface coils in hyperpolarization studies. To this end, we characterize the spatial pro h......-to-noise ratio for hyperpolarized C magnetic resonance C magnetic resonance spectroscopic imaging.......The aim of the present work is to address the challenge of optimal The aim of the present work is to address the challenge of optimal flflip angle calibration of ip angle calibration of C surface coils in C surface coils in hyperpolarization studies. To this end, we characterize the spatial pro...

  19. The solid angle and the Burgers formula in the theory of gradient elasticity: Line integral representation

    Energy Technology Data Exchange (ETDEWEB)

    Lazar, Markus, E-mail: lazar@fkp.tu-darmstadt.de [Heisenberg Research Group, Department of Physics, Darmstadt University of Technology, Hochschulstr. 6, D-64289 Darmstadt (Germany); Po, Giacomo [Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, CA 90095 (United States)

    2014-01-24

    A representation of the solid angle and the Burgers formula as line integral is derived in the framework of the theory of gradient elasticity of Helmholtz type. The gradient version of the Eshelby–deWit representation of the Burgers formula of a closed dislocation loop is given. Such a form is suitable for the numerical implementation in 3D dislocation dynamics (DD).

  20. Spectral editing of weakly coupled spins using variable flip angles in PRESS constant echo time difference spectroscopy: Application to GABA

    Science.gov (United States)

    Snyder, Jeff; Hanstock, Chris C.; Wilman, Alan H.

    2009-10-01

    A general in vivo magnetic resonance spectroscopy editing technique is presented to detect weakly coupled spin systems through subtraction, while preserving singlets through addition, and is applied to the specific brain metabolite γ-aminobutyric acid (GABA) at 4.7 T. The new method uses double spin echo localization (PRESS) and is based on a constant echo time difference spectroscopy approach employing subtraction of two asymmetric echo timings, which is normally only applicable to strongly coupled spin systems. By utilizing flip angle reduction of one of the two refocusing pulses in the PRESS sequence, we demonstrate that this difference method may be extended to weakly coupled systems, thereby providing a very simple yet effective editing process. The difference method is first illustrated analytically using a simple two spin weakly coupled spin system. The technique was then demonstrated for the 3.01 ppm resonance of GABA, which is obscured by the strong singlet peak of creatine in vivo. Full numerical simulations, as well as phantom and in vivo experiments were performed. The difference method used two asymmetric PRESS timings with a constant total echo time of 131 ms and a reduced 120° final pulse, providing 25% GABA yield upon subtraction compared to two short echo standard PRESS experiments. Phantom and in vivo results from human brain demonstrate efficacy of this method in agreement with numerical simulations.

  1. Analysis of the Precision of Variable Flip Angle T1 Mapping with Emphasis on the Noise Propagated from RF Transmit Field Maps.

    Science.gov (United States)

    Lee, Yoojin; Callaghan, Martina F; Nagy, Zoltan

    2017-01-01

    In magnetic resonance imaging, precise measurements of longitudinal relaxation time (T1) is crucial to acquire useful information that is applicable to numerous clinical and neuroscience applications. In this work, we investigated the precision of T1 relaxation time as measured using the variable flip angle method with emphasis on the noise propagated from radiofrequency transmit field ([Formula: see text]) measurements. The analytical solution for T1 precision was derived by standard error propagation methods incorporating the noise from the three input sources: two spoiled gradient echo (SPGR) images and a [Formula: see text] map. Repeated in vivo experiments were performed to estimate the total variance in T1 maps and we compared these experimentally obtained values with the theoretical predictions to validate the established theoretical framework. Both the analytical and experimental results showed that variance in the [Formula: see text] map propagated comparable noise levels into the T1 maps as either of the two SPGR images. Improving precision of the [Formula: see text] measurements significantly reduced the variance in the estimated T1 map. The variance estimated from the repeatedly measured in vivoT1 maps agreed well with the theoretically-calculated variance in T1 estimates, thus validating the analytical framework for realistic in vivo experiments. We concluded that for T1 mapping experiments, the error propagated from the [Formula: see text] map must be considered. Optimizing the SPGR signals while neglecting to improve the precision of the [Formula: see text] map may result in grossly overestimating the precision of the estimated T1 values.

  2. Rapid parametric mapping of the longitudinal relaxation time T1 using two-dimensional variable flip angle magnetic resonance imaging at 1.5 Tesla, 3 Tesla, and 7 Tesla.

    Science.gov (United States)

    Dieringer, Matthias A; Deimling, Michael; Santoro, Davide; Wuerfel, Jens; Madai, Vince I; Sobesky, Jan; von Knobelsdorff-Brenkenhoff, Florian; Schulz-Menger, Jeanette; Niendorf, Thoralf

    2014-01-01

    Visual but subjective reading of longitudinal relaxation time (T1) weighted magnetic resonance images is commonly used for the detection of brain pathologies. For this non-quantitative measure, diagnostic quality depends on hardware configuration, imaging parameters, radio frequency transmission field (B1+) uniformity, as well as observer experience. Parametric quantification of the tissue T1 relaxation parameter offsets the propensity for these effects, but is typically time consuming. For this reason, this study examines the feasibility of rapid 2D T1 quantification using a variable flip angles (VFA) approach at magnetic field strengths of 1.5 Tesla, 3 Tesla, and 7 Tesla. These efforts include validation in phantom experiments and application for brain T1 mapping. T1 quantification included simulations of the Bloch equations to correct for slice profile imperfections, and a correction for B1+. Fast gradient echo acquisitions were conducted using three adjusted flip angles for the proposed T1 quantification approach that was benchmarked against slice profile uncorrected 2D VFA and an inversion-recovery spin-echo based reference method. Brain T1 mapping was performed in six healthy subjects, one multiple sclerosis patient, and one stroke patient. Phantom experiments showed a mean T1 estimation error of (-63±1.5)% for slice profile uncorrected 2D VFA and (0.2±1.4)% for the proposed approach compared to the reference method. Scan time for single slice T1 mapping including B1+ mapping could be reduced to 5 seconds using an in-plane resolution of (2×2) mm2, which equals a scan time reduction of more than 99% compared to the reference method. Our results demonstrate that rapid 2D T1 quantification using a variable flip angle approach is feasible at 1.5T/3T/7T. It represents a valuable alternative for rapid T1 mapping due to the gain in speed versus conventional approaches. This progress may serve to enhance the capabilities of parametric MR based lesion detection and

  3. Faster pediatric 3-T abdominal magnetic resonance imaging: comparison between conventional and variable refocusing flip-angle single-shot fast spin-echo sequences

    Energy Technology Data Exchange (ETDEWEB)

    Ruangwattanapaisarn, Nichanan [Mahidol University, Department of Diagnostic and Therapeutic Radiology, Ramathibodi Hospital, Bangkok (Thailand); Stanford University, LPCH Department of Radiology, Stanford, CA (United States); Loening, Andreas M.; Saranathan, Manojkumar; Vasanawala, Shreyas S. [Stanford University, LPCH Department of Radiology, Stanford, CA (United States); Litwiller, Daniel V. [GE Healthcare, Rochester, MN (United States)

    2015-06-15

    Single-shot fast spin echo (SSFSE) is particularly appealing in pediatric patients because of its motion robustness. However radiofrequency energy deposition at 3 tesla forces long pauses between slices, leading to longer scans, longer breath-holds and more between-slice motion. We sought to learn whether modulation of the SSFSE refocusing flip-angle train could reduce radiofrequency energy deposition without degrading image quality, thereby reducing inter-slice pauses and overall scan times. We modulated the refocusing flip-angle train for SSFSE to minimize energy deposition while minimizing blurring and motion-related signal loss. In a cohort of 50 consecutive patients (25 boys, mean age 5.5 years, range 1 month to 17 years) referred for abdominal MRI we obtained standard SSFSE and variable refocusing flip-angle (vrfSSFSE) images and recorded sequence scan times. Two readers independently scored the images in blinded, randomized order for noise, tissue contrast, sharpness, artifacts and left lobe hepatic signal uniformity on a four-point scale. The null hypothesis of no difference between SSFSE and vrfSSFSE image-quality was assessed with a Mann-Whitney U test, and the null hypothesis of no scan time difference was assessed with the paired t-test. SSFSE and vrfSSFSE mean acquisition times were 54.3 and 26.2 s, respectively (P-value <0.0001). For each reader, SSFSE and vrfSSFSE noise, tissue contrast, sharpness and artifacts were not significantly different (P-values 0.18-0.86). However, SSFSE had better left lobe hepatic signal uniformity (P < 0.01, both readers). vrfSSFSE is twice as fast as SSFSE, with equivalent image quality with the exception of left hepatic lobe signal heterogeneity. (orig.)

  4. An increased flip angle in late phase Gd-EOB-DTPA MRI shows improved performance in bile duct visualization compared to T2w-MRCP

    Energy Technology Data Exchange (ETDEWEB)

    Stelter, Lars, E-mail: lars.stelter@charite.de [Klinik für Radiologie, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin (Germany); Freyhardt, Patrick, E-mail: patrick.freyhardt@charite.de [Klinik für Radiologie, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin (Germany); Grieser, Christian, E-mail: christian.grieser@charite.de [Klinik für Radiologie, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin (Germany); Walter, Thula, E-mail: thula.walter@charite.de [Klinik für Radiologie, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin (Germany); Geisel, Dominik, E-mail: dominik.geisel@charite.de [Klinik für Radiologie, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin (Germany); Baur, Alexander, E-mail: alexander.baur@charite.de [Klinik für Radiologie, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin (Germany); and others

    2014-10-15

    Highlights: • EOB-MRC acquired with a flip angle of 35° revealed a better diagnostic performance compared to T2w-MRCP. • EOB-MRC increased the readers’ confidence in identifying anatomic variations of the biliary tree. • As EOB-MRC comprises functional information it is a valuable adjunct to T2w-MRCP. - Abstract: Objectives: To estimate the additional value of an increased flip angle of 35° in late phase Gd-EOB-DTPA-enhanced magnetic resonance cholangiography, as compared to T2w-MRCP. Methods: 40 adult patients underwent Gd-EOB-DTPA enhanced MRI of the liver including a T2-weighted 3D TSE MRCP (T2w-MRCP) as well as a late phase T1-weighted THRIVE sequences applying a flip angle of 35° (fa35). Two experienced observers evaluated the images regarding the delineation of the different biliary regions using a three-point grading system. A five-point scale was applied to determine the readers’ confidence in identifying anatomical variations of the biliary tree. ROI analysis was performed to compare the signal-to-noise (SNR) and contrast-to-noise (CNR) ratios. Results: The quality for visualizing the biliary tree differed between T2w-MRCP and fa35 (p = <0.001). Late phase EOB-MRC was rated as good for delineating the entire biliary system, whereas T2w-MRCP received an overall poor rating. Especially the depiction of the intrahepatic bile ducts was estimated as problematic in T2w-MRCP. T2w-MRCP and fa35 revealed a discordant assessment of anatomical variations in 12.5% of the cases, comprising a generally higher confidence level for fa35 (4.0 ± 1.1 vs. 2.2 ± 1.2, p = <0.001). SNR proofed to be significantly higher in fa35 (p = <0.001), whereas T2w-MRCP revealed a significantly higher CNR (<0.001). Conclusions: Gd-EOB-DTPA enhanced magnetic resonance cholangiography acquired with a flip angle of 35° revealed a better diagnostic performance compared to T2w-MRCP and might be a valuable adjunct in assessing functional bile duct abnormalities.

  5. Intracranial cerebrospinal fluid spaces imaging using a pulse-triggered three-dimensional turbo spin echo MR sequence with variable flip-angle distribution

    Energy Technology Data Exchange (ETDEWEB)

    Hodel, Jerome [Unite Analyse et Restauration du Mouvement, UMR-CNRS, 8005 LBM ParisTech Ensam, Paris (France); University Paris Est Creteil (UPEC), Creteil (France); Assistance Publique-Hopitaux de Paris, Paris (France); Hopital Henri Mondor, Department of Neuroradiology, Creteil (France); Hopital Henri Mondor, Creteil (France); Silvera, Jonathan [University Paris Est Creteil (UPEC), Creteil (France); Assistance Publique-Hopitaux de Paris, Paris (France); Hopital Henri Mondor, Department of Neuroradiology, Creteil (France); Bekaert, Olivier; Decq, Philippe [Unite Analyse et Restauration du Mouvement, UMR-CNRS, 8005 LBM ParisTech Ensam, Paris (France); University Paris Est Creteil (UPEC), Creteil (France); Assistance Publique-Hopitaux de Paris, Paris (France); Hopital Henri Mondor, Department of Neurosurgery, Creteil (France); Rahmouni, Alain [University Paris Est Creteil (UPEC), Creteil (France); Assistance Publique-Hopitaux de Paris, Paris (France); Hopital Henri Mondor, Department of Radiology, Creteil (France); Bastuji-Garin, Sylvie [University Paris Est Creteil (UPEC), Creteil (France); Assistance Publique-Hopitaux de Paris, Paris (France); Hopital Henri Mondor, Department of Public Health, Creteil (France); Vignaud, Alexandre [Siemens Healthcare, Saint Denis (France); Petit, Eric; Durning, Bruno [Laboratoire Images Signaux et Systemes Intelligents, UPEC, Creteil (France)

    2011-02-15

    To assess the three-dimensional turbo spin echo with variable flip-angle distribution magnetic resonance sequence (SPACE: Sampling Perfection with Application optimised Contrast using different flip-angle Evolution) for the imaging of intracranial cerebrospinal fluid (CSF) spaces. We prospectively investigated 18 healthy volunteers and 25 patients, 20 with communicating hydrocephalus (CH), five with non-communicating hydrocephalus (NCH), using the SPACE sequence at 1.5T. Volume rendering views of both intracranial and ventricular CSF were obtained for all patients and volunteers. The subarachnoid CSF distribution was qualitatively evaluated on volume rendering views using a four-point scale. The CSF volumes within total, ventricular and subarachnoid spaces were calculated as well as the ratio between ventricular and subarachnoid CSF volumes. Three different patterns of subarachnoid CSF distribution were observed. In healthy volunteers we found narrowed CSF spaces within the occipital aera. A diffuse narrowing of the subarachnoid CSF spaces was observed in patients with NCH whereas patients with CH exhibited narrowed CSF spaces within the high midline convexity. The ratios between ventricular and subarachnoid CSF volumes were significantly different among the volunteers, patients with CH and patients with NCH. The assessment of CSF spaces volume and distribution may help to characterise hydrocephalus. (orig.)

  6. Numerical Study of Drop Motion on a Surface with Wettability Gradient and Contact Angle Hysteresis

    CERN Document Server

    Huang, Jun-Jie; Wang, Xinzhu

    2013-01-01

    In this work, the motion of a 2-D drop on a surface with given wettability gradient is studied numerically by a hybrid lattice-Boltzmann finite-difference method using the multiple-relaxation-time collision model. We incorporate the geometric wetting boundary condition that allows accurate implementation of a contact angle hysteresis model. The method is first validated through three benchmark tests, including the layered Poiseuille flow with a viscosity contrast, the motion of a liquid column in a channel with specified wettability gradient and the force balance for a static drop attached to a surface with hysteresis subject to a body force. Then, simulations of a drop on a wall with given wettability gradient are performed under different conditions. The effects of the Reynolds number, the viscosity ratio, the wettability gradient, as well as the contact angle hysteresis on the drop motion are investigated in detail. It is found that the capillary number of the drop in steady state is significantly affected...

  7. Color-gradient lattice Boltzmann model for simulating droplet motion with contact-angle hysteresis.

    Science.gov (United States)

    Ba, Yan; Liu, Haihu; Sun, Jinju; Zheng, Rongye

    2013-10-01

    Lattice Boltzmann method (LBM) is an effective tool for simulating the contact-line motion due to the nature of its microscopic dynamics. In contact-line motion, contact-angle hysteresis is an inherent phenomenon, but it is neglected in most existing color-gradient based LBMs. In this paper, a color-gradient based multiphase LBM is developed to simulate the contact-line motion, particularly with the hysteresis of contact angle involved. In this model, the perturbation operator based on the continuum surface force concept is introduced to model the interfacial tension, and the recoloring operator proposed by Latva-Kokko and Rothman is used to produce phase segregation and resolve the lattice pinning problem. At the solid surface, the color-conserving wetting boundary condition [Hollis et al., IMA J. Appl. Math. 76, 726 (2011)] is applied to improve the accuracy of simulations and suppress spurious currents at the contact line. In particular, we present a numerical algorithm to allow for the effect of the contact-angle hysteresis, in which an iterative procedure is used to determine the dynamic contact angle. Numerical simulations are conducted to verify the developed model, including the droplet partial wetting process and droplet dynamical behavior in a simple shear flow. The obtained results are compared with theoretical solutions and experimental data, indicating that the model is able to predict the equilibrium droplet shape as well as the dynamic process of partial wetting and thus permits accurate prediction of contact-line motion with the consideration of contact-angle hysteresis.

  8. Non-contrast-enhanced 4D MR angiography with STAR spin labeling and variable flip angle sampling: a feasibility study for the assessment of Dural Arteriovenous Fistula.

    Science.gov (United States)

    Jang, Jinhee; Schmitt, Peter; Kim, Bom-yi; Choi, Hyun Seok; Jung, So-Lyung; Ahn, Kook-Jin; Kim, Inseong; Paek, Munyoung; Kim, Bum-soo

    2014-04-01

    This study aimed to evaluate the feasibility of non-contrast-enhanced 4D magnetic resonance angiography (NCE 4D MRA) with signal targeting with alternative radiofrequency (STAR) spin labeling and variable flip angle (VFA) sampling in the assessment of dural arteriovenous fistula (DAVF) in the transverse sinus. Nine patients underwent NCE 4D MRA for the evaluation of DAVF in the transverse sinus at 3 T. One patient was examined twice, once before and once after the interventional treatment. All patients also underwent digital subtraction angiography (DSA) and/or contrast-enhanced magnetic resonance angiography (CEMRA). For the acquisition of NCE 4D MRA, a STAR spin tagging method was used, and a VFA sampling was applied in the data readout module instead of a constant flip angle. Two readers evaluated the NCE 4D MRA data for the diagnosis of DAVF and its type with consensus. The results were compared with those from DSA and/or CEMRA. All patients underwent NCE 4D MRA without any difficulty. Among seven patients with patent DAVFs, all cases showed an early visualization of the transverse sinus on NCE 4D MRA. Except for one case, the type of DAVF of NCE 4D MRA was agreed with that of reference standard study. Cortical venous reflux (CVR) was demonstrated in two cases out of three patients with CVR. NCE 4D MRA with STAR tagging and VFA sampling is technically and clinically feasible and represents a promising technique for assessment of DAVF in the transverse sinus. Further technical developments should aim at improvements of spatial and temporal coverage.

  9. Non-contrast-enhanced 4D MR angiography with STAR spin labeling and variable flip angle sampling: a feasibility study for the assessment of Dural Arteriovenous Fistula

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Jinhee; Kim, Bom-yi; Choi, Hyun Seok; Jung, So-Lyung; Ahn, Kook-Jin; Kim, Bum-soo [The Catholic University of Korea, Department of Radiology, Seoul St. Mary' s Hospital, College of Medicine, Seoul (Korea, Republic of); Schmitt, Peter [Siemens AG, Healthcare Sector, Erlangen (Germany); Kim, Inseong; Paek, Munyoung [Siemens AG, Healthcare, Seoul (Korea, Republic of)

    2014-04-15

    This study aimed to evaluate the feasibility of non-contrast-enhanced 4D magnetic resonance angiography (NCE 4D MRA) with signal targeting with alternative radiofrequency (STAR) spin labeling and variable flip angle (VFA) sampling in the assessment of dural arteriovenous fistula (DAVF) in the transverse sinus. Nine patients underwent NCE 4D MRA for the evaluation of DAVF in the transverse sinus at 3 T. One patient was examined twice, once before and once after the interventional treatment. All patients also underwent digital subtraction angiography (DSA) and/or contrast-enhanced magnetic resonance angiography (CEMRA). For the acquisition of NCE 4D MRA, a STAR spin tagging method was used, and a VFA sampling was applied in the data readout module instead of a constant flip angle. Two readers evaluated the NCE 4D MRA data for the diagnosis of DAVF and its type with consensus. The results were compared with those from DSA and/or CEMRA. All patients underwent NCE 4D MRA without any difficulty. Among seven patients with patent DAVFs, all cases showed an early visualization of the transverse sinus on NCE 4D MRA. Except for one case, the type of DAVF of NCE 4D MRA was agreed with that of reference standard study. Cortical venous reflux (CVR) was demonstrated in two cases out of three patients with CVR. NCE 4D MRA with STAR tagging and VFA sampling is technically and clinically feasible and represents a promising technique for assessment of DAVF in the transverse sinus. Further technical developments should aim at improvements of spatial and temporal coverage. (orig.)

  10. Flipped Learning

    DEFF Research Database (Denmark)

    Holmboe, Peter; Hachmann, Roland

    I FLIPPED LEARNING – FLIP MED VIDEO kan du læse om, hvordan du som underviser kommer godt i gang med at implementere video i undervisning, der har afsæt i tankerne omkring flipped learning. Bogen indeholder fire dele: I Del 1 fokuserer vi på det metarefleksive i at tænke video ind i undervisningen...

  11. Relation between magnetization and Faraday angles produced by ultrafast spin-flip processes within the three-level Λ-type system

    Energy Technology Data Exchange (ETDEWEB)

    Hinschberger, Y. [Departamento de Física e Astronomia, Instituto de Física dos Materiais da Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto (Portugal); Lavoine, J. P. [Departement of Ultrafast Optics and Nanophotonics, Institut de Physique et Chimie des Matériaux de Strasbourg, UMR 7504, CNRS, Université de Strasbourg, 23, Rue du Loess, BP 43, 67034 Strasbourg-Cedex 2 (France)

    2015-08-07

    Ultrafast magneto-optical (MO) experiments constitute a powerful tool to explore the magnetization dynamics of diverse materials. Over the last decade, there have been many theoretical and experimental developments on this subject. However, the relation between the magnetization dynamics and the transient MO response still remains unclear. In this work, we calculate the magnetization of a material, as well as the magneto-optical rotation and ellipticity angles measured in a single-beam experiment. Then, we compare the magnetization to the MO response. The magnetic material is modeled by a three-level Λ-type system, which represents a simple model to describe MO effects induced by an ultrafast laser pulse. Our calculations use the density matrix formalism, while the dynamics of the system is obtained by solving the Lindblad equation taking into account population relaxation and dephasing processes. Furthermore, we consider the Faraday rotation of the optical waves that simultaneously causes spin-flip. We show that the Faraday angles remain proportional to the magnetization only if the system has reached the equilibrium-state, and that this proportionality is directly related to the population and coherence decay rates. For the non-equilibrium situation, the previous proportionality relation is no longer valid. We show that our model is able to interpret some recent experimental results obtained in a single-pulse experiment. We further show that, after a critical pulse duration, the decrease of the ellipticity as a function of the absorbed energy is a characteristic of the system.

  12. A game of RF and gradient pulses: Obtaining an efficient homogeneous flip angle with strong inhomogeneous B1 fields

    NARCIS (Netherlands)

    van Kalleveen, IML

    2016-01-01

    Adiabatic RF pulses are useful pulses for inhomogeneous B1 fields caused by surface RF coils, however the increase in SAR will lengthen the TR, and possibly also the TE if the adiabatic pulses become too long. Using the superadiabaticity theorem the increase in SAR can already be reduced, making it

  13. Flipped Learning

    DEFF Research Database (Denmark)

    Hachmann, Roland; Holmboe, Peter

    arbejde med faglige problemstillinger gennem problembaserede og undersøgende didaktiske designs. Flipped Learning er dermed andet og mere end at distribuere digitale materialer til eleverne forud for undervisning. Flipped Learning er i lige så høj grad et syn på, hvordan undervisning med digitale medier...

  14. Two-voxel spectroscopy with dynamic B0 shimming and flip angle adjustment at 7 T in the human motor cortex.

    Science.gov (United States)

    Lemke, Clark; Hess, Aaron; Clare, Stuart; Bachtiar, Velicia; Stagg, Charlotte; Jezzard, Peter; Emir, Uzay

    2015-07-01

    The aim of this study was to acquire high-quality in vivo (1) H spectra concurrently from two voxels at ultra-high field (7 T) without specialized hardware. To this end, an acquisition scheme was developed in which first-order shims and flip angles are dynamically updated to acquire spectra from both of the brain's motor cortices in an alternating fashion. To validate this acquisition scheme, separate, static, single-voxel acquisitions were also performed for comparison. Six subjects were examined using semi-LASER spectroscopy at 7 T. Barium titanate pads were used to increase the extent of the effective transmit field (B1 (+) ). Spectra were obtained from the hand area of both motor cortices for both acquisition schemes. LCModel was used to determine neurochemical profiles in order to examine variations between acquisition schemes and volumes of interest. The dynamic two-voxel acquisition protocol produced water linewidths (full width at half-maximum between 11.6 and 12.8 Hz) and signal-to-noise ratios similar to those from static single-voxel measurements. The concentrations of 13 individual and 3 combined metabolites with Cramér-Rao lower bounds below 30% were reliably detected for both acquisition schemes, and agreed well with previous postmortem assay and spectroscopy studies. The results show that high spectral quality from two voxels can be acquired concurrently without specialized hardware. This practical technique can be applied to many neuroscience applications.

  15. MR imaging of pulmonary embolism: diagnostic accuracy of contrast-enhanced 3D MR pulmonary angiography, contrast-enhanced low-flip angle 3D GRE, and nonenhanced free-induction FISP sequences.

    Science.gov (United States)

    Kalb, Bobby; Sharma, Puneet; Tigges, Stefan; Ray, Gaye L; Kitajima, Hiroumi D; Costello, James R; Chen, Zhengjia; Martin, Diego R

    2012-04-01

    To evaluate relative detection of pulmonary embolism (PE) with standard bolus-triggered contrast-enhanced breath-hold magnetic resonance (MR) pulmonary angiography, contrast-enhanced recirculation-phase breath-hold low-flip angle three-dimensional (3D) gradient-echo (GRE), and nonenhanced free-induction cardiac- and respiratory-triggered true fast imaging with steady-state precession (FISP) MR sequences. The study was HIPAA compliant and institutional review board approved. Twenty-two patients with a computed tomographic (CT) angiography diagnosis of PE underwent MR imaging within 48 hours of CT. MR included three complementary techniques: MR pulmonary angiography, 3D GRE, and triggered true FISP. Each sequence was analyzed separately by two independent reviewers who recorded presence of emboli in categorized pulmonary artery anatomic territories. CT angiography results were analyzed by a third independent reviewer, who retrospectively recorded presence of emboli using the same format; these results served as the reference standard. Sensitivity, specificity, and positive and negative predictive values for PE detection were calculated for each MR technique on a per-embolus basis, and 95% confidence intervals were calculated according to the efficient-score method. A two-sample t test was used to compare values among MR techniques. Sensitivities for PE detection were 55% for MR pulmonary angiography, 67% for triggered true FISP, and 73% for 3D GRE MR imaging. Combining all three MR sequences improved overall sensitivity to 84%. Specificity was 100% for all detection methods except for MR pulmonary angiography (one false-positive). Agreement between readers was high (κ = 0.87). Embolus detection rates were lowest in the lingula branch for all MR sequences compared with remainder of the vascular territories (P = .07). There are complementary benefits to combining standard MR pulmonary angiography, 3D GRE, and triggered true FISP MR examinations for evaluation of PE.

  16. The effect of electron beam pitch angle and density gradient on solar type III radio bursts

    CERN Document Server

    Pechhacker, Roman

    2012-01-01

    1.5D Particle-In-Cell simulations of a hot, low density electron beam injected into magnetized, maxwellian plasma were used to further explore the alternative non-gyrotropic beam driven electromagnetic emission mechanism, first studied in Tsiklauri (2011). Variation of beam injection angle and background density gradient showed that the emission process is caused by the perpendicular component of the beam injection current, whereas the parallel component only produces Langmuir waves, which play no role in the generation of EM waves in our mechanism. Particular emphasis was put on the case, where the beam is injected perpendicularly to the background magnetic field, as this turned off any electrostatic wave generation along the field and left a purely electromagnetic signal in the perpendicular components. The simulations establish the following key findings: i) Initially waves at a few w_ce/gamma are excited, mode converted and emitted at w_pe ii) The emission intensity along the beam axis is proportional to ...

  17. T2‐Weighted intracranial vessel wall imaging at 7 Tesla using a DANTE‐prepared variable flip angle turbo spin echo readout (DANTE‐SPACE)

    Science.gov (United States)

    Viessmann, Olivia; Li, Linqing; Benjamin, Philip

    2016-01-01

    Purpose To optimize intracranial vessel wall imaging (VWI) at 7T for sharp wall depiction and high boundary contrast. Methods A variable flip angle turbo spin echo scheme (SPACE) was optimized for VWI. SPACE provides black‐blood contrast, but has less crushing effect on cerebrospinal fluid (CSF). However, a delay alternating with nutation for tailored excitation (DANTE) preparation suppresses the signal from slowly moving spins of a few mm per second. Therefore, we optimized a DANTE‐preparation module for 7T. Signal‐to‐noise ratio (SNR), contrast‐to‐noise ratio (CNR), and signal ratio for vessel wall, CSF, and lumen were calculated for SPACE and DANTE‐SPACE in 11 volunteers at the middle cerebral artery (MCA). An exemplar MCA stenosis patient was scanned with DANTE‐SPACE. Results The 7T‐optimized SPACE sequence improved the vessel wall point‐spread function by 17%. The CNR between the wall and CSF was doubled (12.2 versus 5.6) for the DANTE‐SPACE scans compared with the unprepared SPACE. This increase was significant in the right hemisphere (P = 0.016), but not in the left (P = 0.090). The CNR between wall and lumen was halved, but remained at a high value (24.9 versus 56.5). Conclusion The optimized SPACE sequence improves VWI at 7T. Additional DANTE preparation increases the contrast between the wall and CSF. Increased outer boundary contrast comes at the cost of reduced inner boundary contrast. Magn Reson Med 77:655–663, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. PMID:26890988

  18. Validation of 10-Minute Delayed Hepatocyte Phase Imaging with 30° Flip Angle in Gadoxetic Acid-Enhanced MRI for the Detection of Liver Metastasis.

    Directory of Open Access Journals (Sweden)

    Dahye Lee

    Full Text Available To compare 10-minute delayed hepatocyte phase imaging using a 30° flip angle (10 min-FA30 and 20-minute hepatocyte phase imaging using a 10° FA (20 min-FA10 in gadoxetic acid-enhanced MRI of patients with possible liver metastases, regarding lesion-to-liver contrast-to-noise ratio (CNR and focal hepatic lesion (FHL detection to evaluate whether 10 min-FA30 would be superior to 20 min-FA10.Eighty-three patients with 248 liver metastases and 78 benign FHLs who underwent gadoxetic acid-enhanced MRI with 10 min-FA30 and 20 min-FA10 were enrolled. Lesion-to-liver CNRs were compared between the two image groups. Two radiologists independently assessed the presence of FHLs using a four-point scale and detection sensitivity was calculated.The mean CNR for liver metastases on the 10 min-FA30 (248.5 ± 101.6 were significantly higher than that of the 20 min-FA10 (187.4 ± 77.4 (p < 0.001. The mean CNR difference between the two image groups was 61.2 ± 56.8. There was no significant difference in detection sensitivity of FHLs for two readers between 10 min-FA30 (mean 97.7% and 20 min-FA10 (mean 97.9%, irrespective of the lesion size or malignancy.10 min-FA30 yielded higher CNR with similar sensitivity compared to 20 min-FA10. This finding indicates that 10 min-FA30 can potentially replace 20 min-FA10 with higher diagnostic performance and save 10 minutes of time.

  19. Potential for tunable static and dynamic contact angle anisotropy on gradient microscale patterned topographies.

    Science.gov (United States)

    Long, Christopher J; Schumacher, James F; Brennan, Anthony B

    2009-11-17

    Translationally symmetric topographies can be designed to induce anisotropy of static and dynamic contact angles. The validity of ignoring directionality of topography in contact angle characterization was evaluated using microscale patterned topographies. Seven patterned topographies comprising elongated discontinuous microfeatures oriented along parallel paths and one topography comprising ridges were fabricated in a poly(dimethyl siloxane) elastomer (PDMSe). The static contact angle, advancing contact angle, receding contact angle, contact angle hysteresis, and slip angle were measured using water on each surface at three in-plane perspectives, with respect to the feature orientation. Static and dynamic contact angle anisotropies were investigated on the topographies to evaluate the effect of discontinuities along the feature lengths on the anisotropy that has been shown on channels or ridges in previous reports. Discontinuous feature topographies exhibited a statistically significant anisotropy of 2 degrees-6 degrees between the perpendicular and parallel directions, with respect to the static and dynamic contact angles. The ridges topography exhibited much larger 5 degrees-42 degrees anisotropy in the contact angles. The discontinuities along the feature lengths greatly reduced, but did not eliminate, the anisotropies compared to the ridges. This evidence of contact angle anisotropy indicates a need to identify the orientation of topography, in relation to contact angle measurements. It also implies a need to consider directionality in the design of microfluidic devices and self-cleaning surfaces.

  20. Flipped Physics

    Science.gov (United States)

    Kettle, Maria

    2013-01-01

    This paper defines flipped learning and then examines its practical implementation in AS and A2 level physics classes, that is, classes for 16-18 year olds. The effect of this teaching style on student learning behaviour and its impact on test results are evaluated. The paper recounts the difficulties of implementing it and evaluates student…

  1. Flipped Physics

    Science.gov (United States)

    Kettle, Maria

    2013-01-01

    This paper defines flipped learning and then examines its practical implementation in AS and A2 level physics classes, that is, classes for 16-18 year olds. The effect of this teaching style on student learning behaviour and its impact on test results are evaluated. The paper recounts the difficulties of implementing it and evaluates student…

  2. Signal changes in gradient echo images of human brain induced by hypo- and hyperoxia

    DEFF Research Database (Denmark)

    Rostrup, Egill; Larsson, H B; Toft, P B;

    1995-01-01

    The effect of hypoxia (inspired oxygen fraction, FiO2 of 10% and 16%) and hyperoxia (FiO2) of 100%) on gradient echo images of the brain using long echo times was investigated in six healthy volunteers (age 24-28 years). Different flip angles were used with an FiO2 of 10% to assess the importance...

  3. Influences of hydraulic gradient, surface roughness, intersecting angle, and scale effect on nonlinear flow behavior at single fracture intersections

    Science.gov (United States)

    Li, Bo; Liu, Richeng; Jiang, Yujing

    2016-07-01

    Fluid flow tests were conducted on two crossed fracture models for which the geometries of fracture segments and intersections were measured by utilizing a visualization technique using a CCD (charged coupled device) camera. Numerical simulations by solving the Navier-Stokes equations were performed to characterize the fluid flow at fracture intersections. The roles of hydraulic gradient, surface roughness, intersecting angle, and scale effect in the nonlinear fluid flow behavior through single fracture intersections were investigated. The simulation results of flow rate agreed well with the experimental results for both models. The experimental and simulation results showed that with the increment of the hydraulic gradient, the ratio of the flow rate to the hydraulic gradient, Q/J, decreases and the relative difference of Q/J between the calculation results employing the Navier-Stokes equations and the cubic law, δ, increases. When taking into account the fracture surface roughness quantified by Z2 ranging 0-0.42 for J = 1, the value of δ would increase by 0-10.3%. The influences of the intersecting angle on the normalized flow rate that represents the ratio of the flow rate in a segment to the total flow rate, Ra, and the ratio of the hydraulic aperture to the mechanical aperture, e/E, are negligible when J 10-2. Based on the regression analysis on simulation results, a mathematical expression was proposed to quantify e/E, involving variables of J and Rr, where Rr is the radius of truncating circles centered at an intersection. For E/Rr > 10-2, e/E varies significantly and the scale of model has large impacts on the nonlinear flow behavior through intersections, while for E/Rr < 10-3, the scale effect is negligibly small. Finally, a necessary condition to apply the cubic law to fluid flow through fracture intersections is suggested as J < 10-3, E/Rr < 10-3, and Z2 = 0.

  4. Transmit and receive RF fields determination from a single low-tip-angle gradient-echo scan by scaling of SVD data.

    Science.gov (United States)

    Sbrizzi, Alessandro; Raaijmakers, Alexander J E; Hoogduin, Hans; Lagendijk, Jan J W; Luijten, Peter R; van den Berg, Cornelis A T

    2014-07-01

    A new method, called Transmit and Receive Patterns from Low-Tip-angle gradient-Echo Images (TRIPLET), is described which simultaneously maps the B1+ and B1- fields of a transmit/receive radiofrequency coil array. The input data are low-tip-angle gradient-echo images, which can be acquired in a relatively short scanning time. For each voxel in the field of view, a matrix can be assembled with the low-tip-angle gradient-echo image values of the radiofrequency coil array. Applying the singular value decomposition to those matrices, datasets are obtained which show a high resemblance with the true B1+ and B1- fields. These datasets are a voxel-wise scaled version of the true radiofrequency maps. The channel independent scaling parameters can be found by implicitly forcing the reconstructed fields to be solutions of the Maxwell equations. This is achieved by introducing a multipole expansion consisting of Bessel/Fourier functions. Two FDTD simulated radiofrequency fields for two coil array combinations at 7 T and a measured, in vivo dataset at 7 T are investigated to illustrate the singular value decomposition analysis of the low-tip-angle gradient-echo images and to show how the B1+ and B1- fields can be reconstructed by Transmit and Receive Patterns from Low-Tip-angle gradient-Echo Images. The Transmit and Receive Patterns from Low-Tip-angle gradient-Echo Images algorithm can convert the datasets from singular value decomposition analysis of low-tip-angle gradient-echo images to true B1+ and B1- fields. Copyright © 2013 Wiley Periodicals, Inc.

  5. High-spatial-resolution three-dimensional MR cholangiography using a high-sampling-efficiency technique (SPACE) at 3T: comparison with the conventional constant flip angle sequence in healthy volunteers.

    Science.gov (United States)

    Arizono, Shigeki; Isoda, Hiroyoshi; Maetani, Yoji S; Hirokawa, Yuusuke; Shimada, Kotaro; Nakamoto, Yuji; Togashi, Kaori

    2008-09-01

    To evaluate the image quality of high-spatial-resolution three-dimensional magnetic resonance cholangiography (MRC) with a high-sampling-efficiency technique (sampling perfection with application optimized contrasts using different flip angle evolutions [SPACE]) in comparison with a conventional constant flip angle (FA) sequence at 3T. Eighteen volunteers were examined on a 3T MR unit using MRC imaging performed with three different free-breathing three-dimensional T2-weighted turbo spin-echo (TSE) sequences: 1) SPACE (spatial resolution, 1.1x1.0x0.84 mm), 2) constant FA (1.1x1.0x0.84 mm), and 3) SPACE at a higher resolution (SPACE HR; 1.0x0.9x0.644 mm). A five-point scale was used to compare overall image quality and visualization of the third branches of the bile duct (B2, B6, and B8). Depictions of cystic duct insertion and the highest order of bile duct visible were also compared. MRC with SPACE and SPACE HR sequences produced significantly better overall image quality than the constant FA sequence. In all analyses of duct visibility, SPACE and SPACE HR sequences showed higher scores than the constant FA sequence. High-resolution three-dimensional MRC with SPACE at 3T allows high-quality imaging of the biliary tract, and has the ability to depict nondilated intrahepatic bile ducts (IHBD) in healthy volunteers. Copyright (c) 2008 Wiley-Liss, Inc.

  6. Flipping HCI

    Directory of Open Access Journals (Sweden)

    C. Evans

    2016-08-01

    Full Text Available This paper presents the results of two studies involving “flipping the classroom”. Teaching material was delivered via interactive “e-lectures”, allowing face-to-face sessions to focus instead on practice. The e-lectures were designed according to standard usability principles coupled with recent research into the effect of interactivity on learning. The effectiveness of the use of e-lectures was then evaluated using an online survey. The results suggest that students prefer the flexibility offered by e-lectures compared to conventional lectures. The results contribute to our understanding of how this technology fits with face-to-face teaching in the digital age.

  7. Mixture diffusion of adsorbed organic compounds in metal-organic frameworks as studied by magic-angle spinning pulsed-field gradient nuclear magnetic resonance

    Energy Technology Data Exchange (ETDEWEB)

    Gratz, Marcel; Hertel, Stefan; Wehring, Markus; Stallmach, Frank [Faculty of Physics and Earth Science, University of Leipzig, Linnestrasse 5, 04103 Leipzig (Germany); Galvosas, Petrik, E-mail: petrik.galvosas@vuw.ac.nz [MacDiarmid Institute for Advanced Materials and Nanotechnology, SCPS, Victoria University of Wellington, 6012 Wellington (New Zealand)

    2011-04-15

    The magic-angle spinning (MAS) and pulsed-field gradient nuclear magnetic resonance (PFG NMR) techniques have been combined using a commercially available microimaging system providing a gradient in the magic-angle direction of up to {+-}2.6 T m{sup -1}, together with a narrow bore MAS probe. By narrowing the spectral linewidths, detection of the single and mixed molecular species adsorbed in porous material and their respective mobilities becomes possible. Here, we report on protocols for MAS PFG NMR measurements, new methods for the indispensable sample alignment along the MAS rotational axis and gradient direction and first experimental results of diffusion studies on n-hexane and benzene adsorbed in the metal-organic framework MOF-5.

  8. Flip-chip light emitting diode with resonant optical microcavity

    Science.gov (United States)

    Gee, James M.; Bogart, Katherine H.A.; Fischer, Arthur J.

    2005-11-29

    A flip-chip light emitting diode with enhanced efficiency. The device structure employs a microcavity structure in a flip-chip configuration. The microcavity enhances the light emission in vertical modes, which are readily extracted from the device. Most of the rest of the light is emitted into waveguided lateral modes. Flip-chip configuration is advantageous for light emitting diodes (LEDs) grown on dielectric substrates (e.g., gallium nitride LEDs grown on sapphire substrates) in general due to better thermal dissipation and lower series resistance. Flip-chip configuration is advantageous for microcavity LEDs in particular because (a) one of the reflectors is a high-reflectivity metal ohmic contact that is already part of the flip-chip configuration, and (b) current conduction is only required through a single distributed Bragg reflector. Some of the waveguided lateral modes can also be extracted with angled sidewalls used for the interdigitated contacts in the flip-chip configuration.

  9. Flipped Classroom Approach

    Directory of Open Access Journals (Sweden)

    Fezile Ozdamli

    2016-07-01

    Full Text Available Flipped classroom is an active, student-centered approach that was formed to increase the quality of period within class. Generally this approach whose applications are done mostly in Physical Sciences, also attracts the attention of educators and researchers in different disciplines recently. Flipped classroom learning which wide-spreads rapidly in the world, is not well recognized in our country. That is why the aim of study is to attract attention to its potential in education field and provide to make it recognize more by educators and researchers. With this aim, in the study what flipped classroom approach is, flipped classroom technology models, its advantages and limitations were explained.

  10. Evaluation of diamagnetic susceptibility effect on magnetic resonance phase images using gradient echo. On the partial volume effect in calcification

    Energy Technology Data Exchange (ETDEWEB)

    Sakuma, Toshiharu; Yamada, Naoaki; Yamada, Yukinori; Doi, Toyozo [National Cardiovascular Center, Suita, Osaka (Japan)

    1995-02-01

    To examine the ability of magnetic resonance imaging to visualize the diamagnetic susceptibility effects of calcification, phantom experiments using small lead balls in a dilute solution of copper chloride in water were carried out. Gradient echo phase images of the phantoms were obtained using varying imaging parameters (TR, TE, flip angle, slice thickness), and phase shift due to the lead balls was measured. Five choroid plexuses and three pineal glands with calcification were also examined using gradient echo phase images. As a result, it could be seen that the phase shift increased in proportion to both echo time and the ratio held by lead and calcification in a voxel (partial volume effect), and was independent of repetition time and flip angle. It could be confirmed that the gradient echo phase images are useful for detecting the diamagnetic susceptibility effects of calcification. (author).

  11. Flip-invariant SIFT for copy and object detection.

    Science.gov (United States)

    Zhao, Wan-Lei; Ngo, Chong-Wah

    2013-03-01

    Scale-invariant feature transform (SIFT) feature has been widely accepted as an effective local keypoint descriptor for its invariance to rotation, scale, and lighting changes in images. However, it is also well known that SIFT, which is derived from directionally sensitive gradient fields, is not flip invariant. In real-world applications, flip or flip-like transformations are commonly observed in images due to artificial flipping, opposite capturing viewpoint, or symmetric patterns of objects. This paper proposes a new descriptor, named flip-invariant SIFT (or F-SIFT), that preserves the original properties of SIFT while being tolerant to flips. F-SIFT starts by estimating the dominant curl of a local patch and then geometrically normalizes the patch by flipping before the computation of SIFT. We demonstrate the power of F-SIFT on three tasks: large-scale video copy detection, object recognition, and detection. In copy detection, a framework, which smartly indices the flip properties of F-SIFT for rapid filtering and weak geometric checking, is proposed. F-SIFT not only significantly improves the detection accuracy of SIFT, but also leads to a more than 50% savings in computational cost. In object recognition, we demonstrate the superiority of F-SIFT in dealing with flip transformation by comparing it to seven other descriptors. In object detection, we further show the ability of F-SIFT in describing symmetric objects. Consistent improvement across different kinds of keypoint detectors is observed for F-SIFT over the original SIFT.

  12. Solvent Suppression in Intermolecular Multiple-Quantum Coherence Nuclear Magnetic Resonance Spectra with Only Z-axis Gradients

    Institute of Scientific and Technical Information of China (English)

    FENG Hai; ZHANG Sheng-Chun; CAI Shu-Hui; CHEN Zhong; FENG Ji

    2007-01-01

    The solvent peak in the intermolecular multiple-quantum coherence spectra can be suppressed by either applying pulse field gradients or spinning sample along the magic angle direction((δ)=54.7).However,these two methods also suppress the signals of the solute.We design two pulse sequences with only z-axis gradients to suppress the solvent peak without reducing the intensity of solute signals.Compared to the former pulse sequence,the latter pulse sequence is insensitive to the imperfection of pulse flip angles.When the flip angles of the second pulse sequence are purposely deviated 1/10 from the optimal values,the solvent peak is still weak.Theoretical expressions,experimental observations and computer simulations demonstrate that the two methods can be used to effectively suppress solvent peak in intermolecular multiple-quantum coherence spectra.

  13. 90°-Flip-angle three-dimensional double-echo steady-state (3D-DESS) magnetic resonance imaging of the knee: Isovoxel cartilage imaging at 3 T

    Energy Technology Data Exchange (ETDEWEB)

    Moriya, Susumu, E-mail: smoyari@yahoo.co.jp [Ishikawa Clinic, 46-1 Shimokamo-Umenoki-cho, Sakyo-ku, Kyoto-shi, Kyoto 606-0851 (Japan); Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa 920-0942 (Japan); Miki, Yukio, E-mail: yukio.miki@med.osaka-cu.ac.jp [Department of Radiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585 (Japan); Kanagaki, Mitsunori, E-mail: mitsuk@kuhp.kyoto-u.ac.jp [Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University, 54 Shogoin-kawahara-cho, Sakyo-ku, Kyoto-shi, Kyoto 606-8507 (Japan); Matsuno, Yukako, E-mail: ynoma2000jp@yahoo.co.jp [Oike Clinic, 11 Nishinokyo-Shimoai-cho, Nakagyo-ku, Kyoto-shi, Kyoto 604-8436 (Japan); Miyati, Tosiaki, E-mail: ramiyati@mhs.mp.kanazawa-u.ac.jp [Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa 920-0942 (Japan)

    2014-08-15

    Purpose: The purpose of this study was to investigate whether 3D-double echo steady state (3D-DESS) with improved contrast by setting the FA (Flip angle) at 90° is useful in 3D isotropic cartilage imaging of the knee at 3 T. Materials and methods: Imaging was performed in 10 healthy volunteers using 3 methods: with 3D-DESS using FA of 25° and 90°, and with true fast imaging with steady-state precession (True-FISP). The signal-to-noise ratio (SNR) of the synovial fluid and cartilage, and contrast-to-noise ratio (CNR) were measured, and mean values were compared. Visual assessment of artifacts was performed with the cartilage divided into 6 regions. Results: There were no significant differences in synovial fluid SNR in the comparison between FA-90° 3D-DESS and True-FISP (P = 0.364). A significantly higher cartilage SNR was observed with FA-90° 3D-DESS than with True-FISP (P = 0.031). There were no significant differences in synovial fluid-cartilage CNR between FA-90° 3D-DESS and True-FISP (P = 0.892). In the evaluation of artifacts, FA-90° 3D-DESS imaging showed a significantly higher score than True-FISP imaging in the patella and trochlea cartilage (P < 0.001, P < 0.002). Conclusions: FA-90° 3D-DESS is useful in 3D isotropic cartilage imaging of the knee at 3 T.

  14. Exact algebraization of the signal equation of spoiled gradient echo MRI

    Energy Technology Data Exchange (ETDEWEB)

    Dathe, Henning [Department of Orthodontics, Biomechanics Group, University Medical Centre, Goettingen (Germany); Helms, Gunther, E-mail: ghelms@gwdg.d [MR-Research in Neurology and Psychiatry, University Medical Centre, Goettingen (Germany)

    2010-08-07

    The Ernst equation for Fourier transform nuclear magnetic resonance (MR) describes the spoiled steady-state signal created by periodic partial excitation. In MR imaging (MRI), it is commonly applied to spoiled gradient-echo acquisition in the steady state, created by a small flip angle {alpha} at a repetition time TR much shorter than the longitudinal relaxation time T{sub 1}. We describe two parameter transformations of {alpha} and TR/T{sub 1}, which render the Ernst equation as a low-order rational function. Computer algebra can be readily applied for analytically solving protocol optimization, as shown for the dual flip angle experiment. These transformations are based on the half-angle tangent substitution and its hyperbolic analogue. They are monotonic and approach identity for small {alpha} and small TR/T{sub 1} with a third-order error. Thus, the exact algebraization can be readily applied to fast gradient echo MRI to yield a rational approximation in {alpha} and TR/T{sub 1}. This reveals a fundamental relationship between the square of the flip angle and TR/T{sub 1} which characterizes the Ernst angle, constant degree of T{sub 1}-weighting and the influence of the local radio-frequency field.

  15. Flipping Freshman Mathematics

    Science.gov (United States)

    Zack, Laurie; Fuselier, Jenny; Graham-Squire, Adam; Lamb, Ron; O'Hara, Karen

    2015-01-01

    Our study compared a flipped class with a standard lecture class in four introductory courses: finite mathematics, precalculus, business calculus, and calculus 1. The flipped sections watched video lectures outside of class and spent time in class actively working on problems. The traditional sections had lectures in class and did homework outside…

  16. The flipped classroom

    DEFF Research Database (Denmark)

    Triantafyllou, Evangelia

    2015-01-01

    class time is devoted to clarifications and application of this knowledge. The hypothesis is that there could be deep and creative discussions when teacher and students physically meet. This paper presents design considerations for flipped classrooms, and discusses how Moodle can facilitate...... with a discussion of the opportunities and challenges when implementing the flipped model in a virtual learning environment (VLE) like Moodle....

  17. Flipping Freshman Mathematics

    Science.gov (United States)

    Zack, Laurie; Fuselier, Jenny; Graham-Squire, Adam; Lamb, Ron; O'Hara, Karen

    2015-01-01

    Our study compared a flipped class with a standard lecture class in four introductory courses: finite mathematics, precalculus, business calculus, and calculus 1. The flipped sections watched video lectures outside of class and spent time in class actively working on problems. The traditional sections had lectures in class and did homework outside…

  18. Advanced flip chip packaging

    CERN Document Server

    Lai, Yi-Shao; Wong, CP

    2013-01-01

    Advanced Flip Chip Packaging presents past, present and future advances and trends in areas such as substrate technology, material development, and assembly processes. Flip chip packaging is now in widespread use in computing, communications, consumer and automotive electronics, and the demand for flip chip technology is continuing to grow in order to meet the need for products that offer better performance, are smaller, and are environmentally sustainable. This book also: Offers broad-ranging chapters with a focus on IC-package-system integration Provides viewpoints from leading industry executives and experts Details state-of-the-art achievements in process technologies and scientific research Presents a clear development history and touches on trends in the industry while also discussing up-to-date technology information Advanced Flip Chip Packaging is an ideal book for engineers, researchers, and graduate students interested in the field of flip chip packaging.

  19. Flipped Learning in the Workplace

    Science.gov (United States)

    Nederveld, Allison; Berge, Zane L.

    2015-01-01

    Purpose: The purpose of this paper is to serve as a summary of resources on flipped learning for workplace learning professionals. A recent buzzword in the training world is "flipped". Flipped learning and the flipped classroom are hot topics that have emerged in K-12 education, made their way to the university and are now being noticed…

  20. A study on the flip angle for an optimal T1-weighted image based on the 3D-THRIVE MRI technique: Focusing on the detection of a hepatocellular carcinoma (HCC)

    Science.gov (United States)

    Dong, Kyung-Rae; Goo, Eun-Hoe; Lee, Jae-Seung; Chung, Woon-Kwan; Kim, Young-Jae

    2014-04-01

    This study examined the optimal flip angle (FA) for a T1-weighted image in the detection of a hepatocellular carcinoma (HCC). A 3D-T1-weighted high-resolution isotropic volume examination (THRIVE) technique was used to determine the dependence of the signal to noise ratio (SNR) and the contrast-to-noise ratio (CNR) on the change in FA. This study targeted 40 liver cancer patients (25 men and 15 women aged 50 to 70 years with a mean age of 60.32 ± 6.2 years) who visited this hospital to undergo an abdominal MRI examination from January to June 2013. A 3.0 Tesla MRI machine (Philips, Medical System, Achieva) and a MRI receiver coil for data reception with a 16-channel multicoil were used in this study. The THRIVE (repetition time (TR): 8.1 ms, echo time (TE): 3.7 ms, matrix: 172 × 172, slice thickness: 4 mm, gap: 2 mm, field of view (FOV): 350 mm, and band width (BW): 380.1 Hz) technique was applied as a pulse sequence. The time required for the examination was 19 seconds, and the breath-hold technique was used. Axial images were obtained at five FAs: 5, 10, 15, 20 and 25°. The signal intensities of the liver, the lesion and the background noise were measured based on the acquired images before the SNR and the CNR were calculated. To evaluate the image at the FA, we used SPSS for Windows ver. 17.0 to conduct a one-way ANOVA test. A Bonferroni test was conducted as a post-hoc test. The SNRs of the hemorrhagic HCC in the 3D-THRIVE technique were 35.50 ± 4.12, 97.00 ± 10.24, 66.09 ± 7.29, 53.84 ± 5.43, and 42.92 ± 5.11 for FAs of 5, 10, 15, 20, and 25°, respectively (p = 0.0430), whereas the corresponding CNRs were 30.50 ± 3.84, 43.00 ± 5.42, 36.54 ± 4.09, 32.30 ± 2.79, and 31.69 ± 3.21 (p = 0.0003). At a small FA of 10, the SNR and the CNR showed the highest values. As the FA was increased, the SNR and the CNR values showed a decreasing tendency. In conclusion, the optimal T1-weighted image FA should be set to 10° to detect a HCC by using the 3D

  1. Studying nanostructure gradients in injection-molded polypropylene/montmorillonite composites by microbeam small-angle x-ray scattering

    DEFF Research Database (Denmark)

    Stribeck, Norbert; Schneider, Konrad; Zeinolebadi, Ahmad;

    2014-01-01

    The core–shell structure in oriented cylindrical rods of polypropylene (PP) and nanoclay composites (NCs) from PP and montmorillonite (MMT) is studied by microbeam small-angle x-ray scattering (SAXS). The structure of neat PP is almost homogeneous across the rod showing regular semicrystalline st...

  2. The flipped classroom

    DEFF Research Database (Denmark)

    Triantafyllou, Evangelia

    2015-01-01

    One of the novel ideas in teaching that heavily relies on current technology is the “flipped classroom” approach. In a flipped classroom the traditional lecture and homework sessions are inverted. Students are provided with online material in order to gain necessary knowledge before class, while...... class time is devoted to clarifications and application of this knowledge. The hypothesis is that there could be deep and creative discussions when teacher and students physically meet. This paper presents design considerations for flipped classrooms, and discusses how Moodle can facilitate...... communication and information sharing in such classrooms. Furthermore, it provides guidelines for supporting out-of-class instruction in the flipped model by using quizzes and feedback in Moodle, and comments on the potential to follow student use of resources by using Moodle reports. This paper concludes...

  3. Flip Video for Dummies

    CERN Document Server

    Hutsko, Joe

    2010-01-01

    The full-color guide to shooting great video with the Flip Video camera. The inexpensive Flip Video camera is currently one of the hottest must-have gadgets. It's portable and connects easily to any computer to transfer video you shoot onto your PC or Mac. Although the Flip Video camera comes with a quick-start guide, it lacks a how-to manual, and this full-color book fills that void! Packed with full-color screen shots throughout, Flip Video For Dummies shows you how to shoot the best possible footage in a variety of situations. You'll learn how to transfer video to your computer and then edi

  4. FLIPPED LEARNING: PRACTICAL ASPECTS

    Directory of Open Access Journals (Sweden)

    Olena Kuzminska

    2016-03-01

    Full Text Available The article is devoted to issues of implementation of the flipped learning technology in the practice of higher education institutions. The article defines the principles of technology and a model of the educational process, it notes the need to establish an information support system. The article defines online platforms and resources; it describes recommendations for the design of electronic training courses and organization of the students in the process of implementing the proposed model, as well as tools for assessing its effectiveness. The article provides a description of flipped learning implementation scenario and formulates suggestions regarding the use of this model as a mechanism to improve the efficiency of the learning process in the ICT-rich environment of high school: use of learning management systems (LMS and personal learning environments (PLE of participants in a learning process. The article provides an example of implementation of the flipped learning model as a part of the Information Technologies course in the National University of Life and Environmental Sciences of Ukraine (NULES. The article gives examples of tasks, resources and services, results of students’ research activity, as well as an example of the personal learning network, established in the course of implementation of the flipped learning model and elements of digital student portfolios. It presents the results of the monitoring of learning activities and students’ feedback. The author describes cautions against the mass introduction of the flipped learning model without monitoring of readiness of the participants of the educational process for its implementation

  5. Nursing education: Flipping the classroom.

    Science.gov (United States)

    Hessler, Karen L

    2016-02-18

    This article will introduce the innovative educational concept of the "flipped classroom." How to implement the flipped learning model will be addressed within the framework of The Intentional Instruction Environment Model.

  6. Flip-flopping binary black holes.

    Science.gov (United States)

    Lousto, Carlos O; Healy, James

    2015-04-10

    We study binary spinning black holes to display the long term individual spin dynamics. We perform a full numerical simulation starting at an initial proper separation of d≈25M between equal mass holes and evolve them down to merger for nearly 48 orbits, 3 precession cycles, and half of a flip-flop cycle. The simulation lasts for t=20 000M and displays a total change in the orientation of the spin of one of the black holes from an initial alignment with the orbital angular momentum to a complete antialignment after half of a flip-flop cycle. We compare this evolution with an integration of the 3.5 post-Newtonian equations of motion and spin evolution to show that this process continuously flip flops the spin during the lifetime of the binary until merger. We also provide lower order analytic expressions for the maximum flip-flop angle and frequency. We discuss the effects this dynamics may have on spin growth in accreting binaries and on the observational consequences for galactic and supermassive binary black holes.

  7. Spin flips in generic black hole binaries

    CERN Document Server

    Lousto, Carlos O

    2015-01-01

    We study the spin dynamics of individual black holes in a binary system. In particular we focus on the polar precession of spins and the possibility of a complete flip of spins with respect to the orbital plane. We perform a full numerical simulation that displays these characteristics. We evolve equal mass binary spinning black holes for $t=20,000M$ from an initial proper separation of $d=25M$ down to merger after 48.5 orbits. We compute the gravitational radiation from this system and compare it to 3.5 post-Newtonian generated waveforms finding close agreement. We then further use 3.5 post-Newtonian evolutions to show the extension of this spin {flip-flop} phenomenon to unequal mass binaries. We also provide analytic expressions to approximate the maximum {flip-flop} angle and frequency in terms of the binary spins and mass ratio parameters at a given orbital radius. Finally we discuss the effect this spin {flip-flop} would have on accreting matter and other potential observational effects.

  8. Flipping the Classroom

    Science.gov (United States)

    Riendeau, Diane

    2012-11-01

    A recent trend in education is the ``flipped'' or ``reversed'' classroom. In this educational model, students view videos of the lectures as their homework and class time is used for activities and solving problems that might have been assigned as homework in a traditional classroom. Although far from an expert on flipping the classroom, I can see some merit in the idea. When students watch the videos at home, they can start and restart the lecture as often as they like. The lectures are also available for review before the exam. Class time can be used for higher-order questioning, experiments, and problem solving.

  9. Self-diffusion of electrolyte species in model battery electrodes using Magic Angle Spinning and Pulsed Field Gradient Nuclear Magnetic Resonance

    Science.gov (United States)

    Tambio, Sacris Jeru; Deschamps, Michaël; Sarou-Kanian, Vincent; Etiemble, Aurélien; Douillard, Thierry; Maire, Eric; Lestriez, Bernard

    2017-09-01

    Lithium-ion batteries are electrochemical storage devices using the electrochemical activity of the lithium ion in relation to intercalation compounds owing to mass transport phenomena through diffusion. Diffusion of the lithium ion in the electrode pores has been poorly understood due to the lack of experimental techniques for measuring its self-diffusion coefficient in porous media. Magic-Angle Spinning, Pulsed Field Gradient, Stimulated-Echo Nuclear Magnetic Resonance (MAS-PFG-STE NMR) was used here for the first time to measure the self-diffusion coefficients of the electrolyte species in the LP30 battery electrolyte (i.e. a 1 M solution of LiPF6 dissolved in 1:1 Ethylene Carbonate - Dimethyl Carbonate) in model composites. These composite electrodes were made of alumina, carbon black and PVdF-HFP. Alumina's magnetic susceptibility is close to the measured magnetic susceptibility of the LP30 electrolyte thereby limiting undesirable internal field gradients. Interestingly, the self-diffusion coefficient of lithium ions decreases with increasing carbon content. FIB-SEM was used to describe the 3D geometry of the samples. The comparison between the reduction of self-diffusion coefficients as measured by PFG-NMR and as geometrically derived from FIB/SEM tortuosity values highlights the contribution of specific interactions at the material/electrolyte interface on the lithium transport properties.

  10. 'Flipping' the Classroom.

    Science.gov (United States)

    Billings, Diane M

    2016-09-01

    This article is one in a series on the roles of adjunct clinical faculty and preceptors, who teach nursing students and new graduates to apply knowledge in clinical settings. This article describes the benefits and challenges of using a "flipped" classroom to promote active engagement among learners and more meaningful interaction between learners and educators.

  11. Flipping the Classroom Revisited

    Science.gov (United States)

    Riendeau, Diane

    2013-02-01

    I received many emails following the first column on flipping the classroom. Many of my local colleagues also approached me at our physics alliance, Physics Northwest. Teachers are very interested in this new pedagogy. As I result, I wanted to share some more videos to inspire you.

  12. MICROELECTRONICS: Flip the Chip.

    Science.gov (United States)

    Wong, C P; Luo, S; Zhang, Z

    2000-12-22

    As integrated circuit fabrication advances rapidly and the market for faster, lighter, smaller, yet less expensive electronic products accelerates, electronic packaging faces its own challenges. In this Perspective, Wong, Luo, and Zhang describe recent advances in flip chip packaging. This technology has many advantages over the conventional wire bonding technology and offers the possibility of low-cost electronic assembly for modern electronic products.

  13. Flipped Classroom, active Learning?

    DEFF Research Database (Denmark)

    Andersen, Thomas Dyreborg; Levinsen, Henrik; Philipps, Morten

    2015-01-01

    Action research is conducted in three physics classes over a period of eighteen weeks with the aim of studying the effect of flipped classroom on the pupils agency and learning processes. The hypothesis is that flipped classroom teaching will potentially allocate more time to work actively...... with the teaching subject compared to more traditional teaching, where introductions and theoretical monologs conducted by the teacher prevail. In addition it is assumed that the pupils learning processes move towards more independency and metacognitive thinking.   During the study period interventions...... didactic workshop with the involved teachers. One of the demands of the didactic design is to include a video embedded in a formative evaluation sheet produced in Google Drive by the teachers themselves. The didactic analysis of the collected audio and video recordings will be presented at the NOFA 5...

  14. Flip the classroom.

    Science.gov (United States)

    Li, Simon

    2015-11-01

    Given the huge expansion in medical knowledge it is both practical and expedient to make better use of students' time with aids for effective learning, rather than by increasing the length of time it takes to earn a medical degree. Embracing a 'flipped classroom' approach is a way to free-up classroom time to promote active learning through opportunities such as case-based and team-based exercises.

  15. Magnetic resonance in cartilaginous lesions of the knee joint with three-dimensional gradient-echo imaging

    Energy Technology Data Exchange (ETDEWEB)

    Reiser, M.F.; Bongartz, G.; Erlemann, R.; Gaebert, K.; Stoeber, U.; Peters, P.E.; Strobel, M.; Pauly, T.

    1988-10-01

    Diagnosis of chondromalacia of the patellofemoral joint using three-dimensional gradient-echo sequences was investigated in 41 patients, with arthroscopic verification in 25 patients. In vitro examinations in human caderveric patellae were performed in order to determine optimal imaging parameters. FLASH (T/sub R/=40 ms, T/sub E/=10 ms, flip angle=30/sup 0/) and FISP (T/sub R/=40 ms, T/sub E/=10 ms, flip angle=40/sup 0/) were used in clinical studies. The therapeutically relevant differentiation of major and minor degrees of chondromalacia seems to be possible. 30/sup 0/ FLASH-images in the axial plane proved to be the most efficacious technique for the diagnosis of chondromalacia. (orig./GDG).

  16. Segment adaptive gradient angle interpolation.

    Science.gov (United States)

    Zwart, Christine M; Frakes, David H

    2013-08-01

    We introduce a new edge-directed interpolator based on locally defined, straight line approximations of image isophotes. Spatial derivatives of image intensity are used to describe the principal behavior of pixel-intersecting isophotes in terms of their slopes. The slopes are determined by inverting a tridiagonal matrix and are forced to vary linearly from pixel-to-pixel within segments. Image resizing is performed by interpolating along the approximated isophotes. The proposed method can accommodate arbitrary scaling factors, provides state-of-the-art results in terms of PSNR as well as other quantitative visual quality metrics, and has the advantage of reduced computational complexity that is directly proportional to the number of pixels.

  17. Clinical application of gradient echo sequences with prolonged repetition times

    Energy Technology Data Exchange (ETDEWEB)

    Tiling, R.; Fink, U.; Deimling, M.; Bauer, W.M.; Yousry, T.; Krauss, B.

    1988-09-01

    Studies designed to optimise image contrasts of gradient echo sequences showed, that especially repetition times between 250 and 500 ms in combination with adequate echo times and flip angles provide new image contrasts. The clinical purpose of gradient echo sequences with longer TR was systematically evaluated in 450 patients. A major advantage of GE sequences was the low signal intensity of fat and bone tissue. On the other hand differnt pathologic changes showed a high signal intensity in comparison to T/sub 2/ weighted spin echo sequences as well. With the possibility of multiple slices GE sequences were of outstanding diagnostic value especially in MR of soft tissue and of the musculoskeletal system. T/sub 2/ weighted SE sequences provided no additional informations and could therefore be omitted in a great number of examinations.

  18. Teaching Tip: The Flipped Classroom

    Science.gov (United States)

    Mok, Heng Ngee

    2014-01-01

    The flipped classroom has been gaining popularity in recent years. In theory, flipping the classroom appears sound: passive learning activities such as unidirectional lectures are pushed to outside class hours in the form of videos, and precious class time is spent on active learning activities. Yet the courses for information systems (IS)…

  19. Adventures in Flipping College Algebra

    Science.gov (United States)

    Van Sickle, Jenna

    2015-01-01

    This paper outlines the experience of a university professor who implemented flipped learning in two sections of college algebra courses for two semesters. It details how the courses were flipped, what technology was used, advantages, challenges, and results. It explains what students do outside of class, what they do inside class, and discusses…

  20. Flipped models in Trinification: A Comprehensive Approach

    CERN Document Server

    Rodríguez, Oscar; Ponce, William A; Rojas, Eduardo

    2016-01-01

    By considering the 3-3-1 and the left-right symmetric models as low energy effective theories of the trinification group, alternative versions of these models are found. The new neutral gauge bosons in the universal 3-3-1 model and its flipped versions are considered; also, the left-right symmetric model and the two flipped variants of it are also studied. For these models, the couplings of the $Z'$ bosons to the standard model fermions are reported. The explicit form of the null space of the vector boson mass matrix for an arbitrary Higgs tensor and gauge group is also presented. In the general framework of the trinification gauge group, and by using the LHC experimental results and EW precision data, limits on the $Z'$ mass and the mixing angle between $Z$ and the new gauge bosons $Z'$ are imposed. The general results call for very small mixing angles in the range $10^{-3}$ radians and $M_{Z'}$ > 2.5 TeV.

  1. A flipped 331 model

    CERN Document Server

    Fonseca, Renato M

    2016-01-01

    Models based on the extended $SU(3)_{C}\\times SU(3)_{L}\\times U(1)_{X}$ (331) gauge group usually follow a common pattern: two families of left-handed quarks are placed in anti-triplet representations of the $SU(3)_{L}$ group; the remaining quark family, as well as the left-handed leptons, are assigned to triplets (or vice-versa). In this work we present a flipped 331 model where this scheme is reversed: all three quarks families are in the same representation and it is the lepton families which are discriminated by the gauge symmetry. We discuss fermion masses and mixing, as well as $Z'$ interactions, in a minimal model implementing this idea.

  2. Crystallization by stochastic flips

    Science.gov (United States)

    Bodini, Olivier; Fernique, Thomas; Regnault, Damien

    2010-04-01

    Tilings are often used as a toy model for quasicrystals, with the ground states corresponding to the tilings satisfying some local properties (matching rules). In this context, a challenging problem is to provide a theory for quasicrystals growth. One of the proposed theories is the relaxation process. One assumes that the entropy of a tiling increases with the number of tilings which can be formed with the same tiles, while its energy is proportional to the ratio of satisfied matching rules. Then, by starting from an entropically stabilized tiling at high temperature and by decreasing the temperature, the phason flips which decrease (resp. increase) the energy would become more and more favoured (resp. inhibited). Ideally, the tiling eventually satisfies all the matching rules, and thus shows a quasicrystalline structure. This paper describes a stochastic process inspired by this and discusses its convergence rate.

  3. Practical Quantum Coin Flipping

    CERN Document Server

    Pappa, Anna; Diamanti, Eleni; Kerenidis, Iordanis

    2011-01-01

    In this article we show for the first time that quantum coin flipping with security guarantees that are strictly better than any classical protocol is possible to implement with current technology. Our protocol is tolerant to both loss and noise and takes into account all aspects of an experimental implementation like multi-photon pulses emitted by practical photon sources, channel noise, system loss, detector dark counts and finite quantum efficiency. We calculate the abort probability when both players are honest, as well as the probability of one player forcing his desired outcome. For channel length up to 21 km, we achieve a cheating probability that is better than in any classical protocol. Our protocol is easy to implement using attenuated laser pulses, with no need for entangled photons or any other specific resources.

  4. Spin flipping a stored polarized proton beam

    Science.gov (United States)

    Caussyn, D. D.; Derbenev, Ya. S.; Ellison, T. J.; Lee, S. Y.; Rinckel, T.; Schwandt, P.; Sperisen, F.; Stephenson, E. J.; von Przewoski, B.; Blinov, B. B.; Chu, C. M.; Courant, E. D.; Crandell, D. A.; Kaufman, W. A.; Krisch, A. D.; Nurushev, T. S.; Phelps, R. A.; Ratner, L. G.; Wong, V. K.; Ohmori, C.

    1994-11-01

    We recently studied the spin flipping of a vertically polarized, stored 139-MeV proton beam. To flip the spin, we induced an rf depolarizing resonance by sweeping our rf solenoid magnet's frequency through the resonance frequency. With multiple spin flips, we found a polarization loss of 0.0000+/-0.0005 per spin flip under the best conditions; this loss increased significantly for small changes in the conditions. Minimizing the depolarization during each spin flip is especially important because frequent spin flipping could significantly reduce the systematic errors in stored polarized-beam experiments.

  5. 流动质子NMR信号强度与梯度回波中翻转角间的关系%THE RELATIONSHIP BETWEEN SIGNAL INTENSITY OF FLOWING PROTONS AND FLIP ANGLE IN FLASH

    Institute of Scientific and Technical Information of China (English)

    汪家旺; 罗立民

    2002-01-01

    梯度回波脉冲序列对血流分布和血管结构极其敏感.当脉冲序列中的参数发生变化时,血流的NMR(Nuclear Magnetic Resonance)信号也发生改变.本文阐述了流动质子NMR信号强度与FLASH(fast low angle shot)序列中的射频翻转角间的关系.并通过模拟实验验证了此关系的有效性.这种关系对在临床应用NMR血管成像时选取梯度回波脉冲序列有一定的指导意义.

  6. To Flip or Not to Flip? An Exploratory Study Comparing Student Performance in Calculus I

    Science.gov (United States)

    Schroeder, Larissa B.; McGivney-Burelle, Jean; Xue, Fei

    2015-01-01

    The purpose of this exploratory, mixed-methods study was to compare student performance in flipped and non-flipped sections of Calculus I. The study also examined students' perceptions of the flipping pedagogy. Students in the flipped courses reported spending, on average, an additional 1-2 hours per week outside of class on course content.…

  7. To Flip or Not to Flip? An Exploratory Study Comparing Student Performance in Calculus I

    Science.gov (United States)

    Schroeder, Larissa B.; McGivney-Burelle, Jean; Xue, Fei

    2015-01-01

    The purpose of this exploratory, mixed-methods study was to compare student performance in flipped and non-flipped sections of Calculus I. The study also examined students' perceptions of the flipping pedagogy. Students in the flipped courses reported spending, on average, an additional 1-2 hours per week outside of class on course content.…

  8. Single-transistor-clocked flip-flop

    Science.gov (United States)

    Zhao, Peiyi; Darwish, Tarek; Bayoumi, Magdy

    2005-08-30

    The invention provides a low power, high performance flip-flop. The flip-flop uses only one clocked transistor. The single clocked transistor is shared by the first and second branches of the device. A pulse generator produces a clock pulse to trigger the flip-flop. In one preferred embodiment the device can be made as a static explicit pulsed flip-flop which employs only two clocked transistors.

  9. The Flipped Classroom in Counselor Education

    Science.gov (United States)

    Moran, Kristen; Milsom, Amy

    2015-01-01

    The flipped classroom is proposed as an effective instructional approach in counselor education. An overview of the flipped-classroom approach, including advantages and disadvantages, is provided. A case example illustrates how the flipped classroom can be applied in counselor education. Recommendations for implementing or researching flipped…

  10. A Flipped Classroom Redesign in General Chemistry

    Science.gov (United States)

    Reid, Scott A.

    2016-01-01

    The flipped classroom continues to attract significant attention in higher education. Building upon our recent parallel controlled study of the flipped classroom in a second-term general chemistry course ("J. Chem. Educ.," 2016, 93, 13-23), here we report on a redesign of the flipped course aimed at scaling up total enrollment while…

  11. Flipping a Calculus Class: One Instructor's Experience

    Science.gov (United States)

    Palmer, Katrina

    2015-01-01

    This paper describes one instructor's experiences during a year of flipping four calculus classes. The first exploration attempts to understand student expectations of a math class and their preference towards a flipped classroom. The second examines success of students from a flipped classroom, and the last investigates relationships with student…

  12. A Flipped Classroom Redesign in General Chemistry

    Science.gov (United States)

    Reid, Scott A.

    2016-01-01

    The flipped classroom continues to attract significant attention in higher education. Building upon our recent parallel controlled study of the flipped classroom in a second-term general chemistry course ("J. Chem. Educ.," 2016, 93, 13-23), here we report on a redesign of the flipped course aimed at scaling up total enrollment while…

  13. How To Prepare Effective Flip Charts.

    Science.gov (United States)

    National Audio-Visual Supply, East Rutherford, NJ.

    Designed to help create effective flip chart presentations, this guide contains the basic techniques and helpful hints necessary to produce professional, attention-getting flip charts in a step-by-step procedure format. Five topics are addressed in the guide: (1) eight steps to a successful meeting presentation; (2) advantages of flip chart…

  14. Flip-Flops: Avoid a Flip-Flop Fiasco

    Science.gov (United States)

    ... quality, soft leather. Leather minimizes the potential for blisters and other types of irritation. Do gently bend the flip-flop from end to end, ensuring it bends at the ball of the foot. Shoes of any kind should never fold in half. ...

  15. Advanced morphological 3D magnetic resonance observation of cartilage repair tissue (MOCART) scoring using a new isotropic 3D proton-density, turbo spin echo sequence with variable flip angle distribution (PD-SPACE) compared to an isotropic 3D steady-state free precession sequence (True-FISP) and standard 2D sequences.

    Science.gov (United States)

    Welsch, Goetz H; Zak, Lukas; Mamisch, Tallal C; Paul, Dominik; Lauer, Lars; Mauerer, Andreas; Marlovits, Stefan; Trattnig, Siegfried

    2011-01-01

    To evaluate a new isotropic 3D proton-density, turbo-spin-echo sequence with variable flip-angle distribution (PD-SPACE) sequence compared to an isotropic 3D true-fast-imaging with steady-state-precession (True-FISP) sequence and 2D standard MR sequences with regard to the new 3D magnetic resonance observation of cartilage repair tissue (MOCART) score. Sixty consecutive MR scans on 37 patients (age: 32.8 ± 7.9 years) after matrix-associated autologous chondrocyte transplantation (MACT) of the knee were prospectively included. The 3D MOCART score was assessed using the standard 2D sequences and the multiplanar-reconstruction (MPR) of both isotropic sequences. Statistical, Bonferroni-corrected correlation as well as subjective quality analysis were performed. The correlation of the different sequences was significant for the variables defect fill, cartilage interface, bone interface, surface, subchondral lamina, chondral osteophytes, and effusion (Pearson coefficients 0.514-0.865). Especially between the standard sequences and the 3D True-FISP sequence, the variables structure, signal intensity, subchondral bone, and bone marrow edema revealed lower, not significant, correlation values (0.242-0.383). Subjective quality was good for all sequences (P ≥ 0.05). Artifacts were most often visible on the 3D True-FISP sequence (P < 0.05). Different isotropic sequences can be used for the 3D evaluation of cartilage repair with the benefits of isotropic 3D MRI, MPR, and a significantly reduced scan time, where the 3D PD-SPACE sequence reveals the best results. Copyright © 2010 Wiley-Liss, Inc.

  16. Crack and flip phacoemulsification technique.

    Science.gov (United States)

    Fine, I H; Maloney, W F; Dillman, D M

    1993-11-01

    The crack and flip phacoemulsification technique combines the advantages of circumferential division of the nucleus and nucleofactis techniques. As such, it adds safety and control to the procedure. We describe each of the surgical maneuvers, including machine settings, and explain the rationale for maneuvers and machine settings.

  17. Neutron spin-flip scattering of nanocrystalline cobalt

    Energy Technology Data Exchange (ETDEWEB)

    Honecker, D; Doebrich, F; Michels, A [Laboratory for the Physics of Advanced Materials, University of Luxembourg, 162A Avenue de la Faiencerie, L-1511 Luxembourg (Luxembourg); Dewhurst, C D; Wiedenmann, A, E-mail: andreas.michels@uni.l [Institut Laue-Langevin, 6 Rue Jules Horowitz, BP 156, F-38042 Grenoble Cedex 9 (France)

    2011-01-12

    We report results of longitudinal (one-dimensional) neutron polarization analysis on polycrystalline bulk Co with an average crystallite size of D = 10 nm. The spin-flip small-angle neutron scattering (SANS) data are analyzed in the approach-to-saturation regime within the framework of micromagnetic theory. In particular, we provide a closed-form expression for the spin-flip SANS cross section d{Sigma}{sup {+-}-+}/d{Omega}. From the data analysis, we find a room-temperature value of A = (2.6 {+-} 0.1) x 10{sup -11} J m{sup -1} for the exchange-stiffness constant, which agrees well with earlier data.

  18. Laser textured surface gradients

    Science.gov (United States)

    Ta, Van Duong; Dunn, Andrew; Wasley, Thomas J.; Li, Ji; Kay, Robert W.; Stringer, Jonathan; Smith, Patrick J.; Esenturk, Emre; Connaughton, Colm; Shephard, Jonathan D.

    2016-05-01

    This work demonstrates a novel technique for fabricating surfaces with roughness and wettability gradients and their subsequent applications for chemical sensors. Surface roughness gradients on brass sheets are obtained directly by nanosecond laser texturing. When these structured surfaces are exposed to air, their wettability decreases with time (up to 20 days) achieving both spatial and temporal wettability gradients. The surfaces are responsive to organic solvents. Contact angles of a series of dilute isopropanol solutions decay exponentially with concentration. In particular, a fall of 132° in contact angle is observed on a surface gradient, one order of magnitude higher than the 14° observed for the unprocessed surface, when the isopropanol concentration increased from 0 to 15.6 wt%. As the wettability changes gradually over the surface, contact angle also changes correspondingly. This effect offers multi-sensitivity at different zones on the surface and is useful for accurate measurement of chemical concentration.

  19. Flipping the Graduate Qualitative Research Methods Classroom: Did It Lead to Flipped Learning?

    Science.gov (United States)

    Earley, Mark

    2016-01-01

    The flipped, or inverted, classroom has gained popularity in a variety of fields and at a variety of educational levels, from K-12 through higher education. This paper describes the author's positive experience flipping a graduate qualitative research methods classroom. After a review of the current literature on flipped classrooms in higher…

  20. How to Flip the Classroom--"Productive Failure or Traditional Flipped Classroom" Pedagogical Design?

    Science.gov (United States)

    Song, Yanjie; Kapur, Manu

    2017-01-01

    The paper reports a quasi-experimental study comparing the "traditional flipped classroom" pedagogical design with the "productive failure" (Kapur, 2016) pedagogical design in the flipped classroom for a 2-week curricular unit on polynomials in a Hong Kong Secondary school. Different from the flipped classroom where students…

  1. Supermassive black hole spin-flip during the inspiral

    Energy Technology Data Exchange (ETDEWEB)

    Gergely, Laszlo A [Department of Theoretical Physics, University of Szeged (Hungary); Biermann, Peter L [MPI for Radioastronomy, Bonn (Germany); Caramete, Laurentiu I, E-mail: gergely@physx.u-szeged.h, E-mail: plbiermann@mpifr-bonn.mpg.d, E-mail: lcaramete@gmail.co [Institute for Space Sciences, Bucharest (Romania)

    2010-10-07

    During post-Newtonian evolution of a compact binary, a mass ratio {nu} different from 1 provides a second small parameter, which can lead to unexpected results. We present a statistics of supermassive black hole candidates, which enables us first to derive their mass distribution, and then to establish a logarithmically even probability in {nu} of the mass ratios at their encounter. In the mass ratio range {nu} in (1/30, 1/3) of supermassive black hole mergers representing 40% of all possible cases, the combined effect of spin-orbit precession and gravitational radiation leads to a spin-flip of the dominant spin during the inspiral phase of the merger. This provides a mechanism for explaining a large set of observations on X-shaped radio galaxies. In another 40% with mass ratios {nu} in (1/30, 1/1000) a spin-flip never occurs, while in the remaining 20% of mergers with mass ratios {nu} in (1/3, 1) it may occur during the plunge. We analyze the magnitude of the spin-flip angle occurring during the inspiral as a function of the mass ratio and original relative orientation of the spin and orbital angular momentum. We also derive a formula for the final spin at the end of the inspiral in this mass ratio range.

  2. Supermassive black hole spin-flip during the inspiral

    CERN Document Server

    Gergely, László Á; Caramete, Laurenţiu I

    2010-01-01

    During post-Newtonian evolution of a compact binary, a mass ratio different from one provides a second small parameter, which can lead to unexpected results. We present a statistics of supermassive black hole candidates, which enables us first to derive their mass distribution, then to establish a logarithmically even probability of the mass ratios at their encounter. In the mass ratio range (1/30,1/3) of supermassive black hole mergers representing 40% of all possible cases, the combined effect of spin-orbit precession and gravitational radiation leads to a spin-flip of the dominant spin during the inspiral phase of the merger. This provides a mechanism for explaining a large set of observations on X-shaped radio galaxies. In another 40%, with mass ratios (1/30,1/1000) a spin-flip never happens, while in the remaining 20% of mergers with mass ratios (1/3,1) it may occur during the plunge. We analyze the magnitude of the spin-flip angle occurring during the inspiral as function of the mass ratio and original ...

  3. To Flip or Not to Flip? Analysis of a Flipped Classroom Pedagogy in a General Biology Course

    Science.gov (United States)

    Heyborne, William H.; Perrett, Jamis J.

    2016-01-01

    In an attempt to better understand the flipped technique and evaluate its purported superiority in terms of student learning gains, the authors conducted an experiment comparing a flipped classroom to a traditional lecture classroom. Although the outcomes were mixed, regarding the superiority of either pedagogical approach, there does seem to be a…

  4. The Flipped Classroom: A Twist on Teaching

    Science.gov (United States)

    Schmidt, Stacy M. P.; Ralph, David L.

    2016-01-01

    The traditional classroom has utilized the "I Do", "We Do", "You Do" as a strategy for teaching for years. The flipped classroom truly flips that strategy. The teacher uses "You Do", "We Do", "I Do" instead. Homework, inquiry, and investigation happen in the classroom. At home students…

  5. Flipping Quantitative Classes: A Triple Win

    Science.gov (United States)

    Swart, William; Wuensch, Karl L.

    2016-01-01

    In the "flipped" class, students use online materials to learn what is traditionally learned by attending lectures, and class time is used for interactive group learning. A required quantitative business class was taught as a flipped classroom in an attempt to improve student satisfaction in the course and reduce the "transactional…

  6. Best Practices for Launching a Flipped Classroom

    Science.gov (United States)

    Hall, Ashley A.; DuFrene, Debbie D.

    2016-01-01

    Popularity is growing for flipped classroom instruction, which replaces lectures with out-of-class delivery of streaming video, reading materials, online chats, and other modalities. Face-to-face class time is spent on instructor-student and student-student interaction, including small group problem solving and discussion. Classroom flipping has…

  7. Technology: Differentiating Instruction by Flipping the Classroom

    Science.gov (United States)

    Siegle, Del

    2014-01-01

    Flipping the classroom can be an effective instructional strategy for differentiating instruction for gifted and talented students. The author presents a rationale for using the strategy with gifted students, possible problems educators might encounter, and practical tips for beginning the process of flipping the classroom.

  8. Just in Time to Flip Your Classroom

    Science.gov (United States)

    Lasry, Nathaniel; Dugdale, Michael; Charles, Elizabeth

    2014-01-01

    With advocates like Sal Khan and Bill Gates, flipped classrooms are attracting an increasing amount of media and research attention. We had heard Khan's TED talk and were aware of the concept of inverted pedagogies in general. Yet it really hit home when we accidentally flipped our classroom. Our objective was to better prepare our students…

  9. The Flipped Classroom. IDEA Paper #57

    Science.gov (United States)

    Braseby, Anne M.

    2014-01-01

    Use of the word "flipped" has become the latest buzzword in the educational world. This paper explores the different uses of the term "flipped," examines the research to date, and discusses how and why teachers are starting to use the new model. It offers suggestions for activities both inside and outside of the classroom to…

  10. Conceptualizing "Homework" in Flipped Mathematics Classes

    Science.gov (United States)

    de Araujo, Zandra; Otten, Samuel; Birisci, Salih

    2017-01-01

    Flipped instruction is becoming more common in the United States, particularly in mathematics classes. One of the defining characteristics of this increasingly popular instructional format is the homework teachers assign. In contrast to traditional mathematics classes in which homework consists of problem sets, homework in flipped classes often…

  11. Just in Time to Flip Your Classroom

    Science.gov (United States)

    Lasry, Nathaniel; Dugdale, Michael; Charles, Elizabeth

    2014-01-01

    With advocates like Sal Khan and Bill Gates, flipped classrooms are attracting an increasing amount of media and research attention. We had heard Khan's TED talk and were aware of the concept of inverted pedagogies in general. Yet it really hit home when we accidentally flipped our classroom. Our objective was to better prepare our students…

  12. Diverse Perspectives on a Flipped Biostatistics Classroom

    Science.gov (United States)

    Schwartz, Todd A.; Andridge, Rebecca R.; Sainani, Kirstin L.; Stangle, Dalene K.; Neely, Megan L.

    2016-01-01

    "Flipping" the classroom refers to a pedagogical approach in which students are first exposed to didactic content outside the classroom and then actively use class time to apply their newly attained knowledge. The idea of the flipped classroom is not new, but has grown in popularity in recent years as the necessary technology has…

  13. Just in Time to Flip Your Classroom

    Science.gov (United States)

    Lasry, Nathaniel; Dugdale, Michael; Charles, Elizabeth

    2014-01-01

    With advocates like Sal Khan and Bill Gates, flipped classrooms are attracting an increasing amount of media and research attention.2 We had heard Khan's TED talk and were aware of the concept of inverted pedagogies in general. Yet it really hit home when we accidentally flipped our classroom. Our objective was to better prepare our students for class. We set out to effectively move some of our course content outside of class and decided to tweak the Just-in-Time Teaching approach (JiTT).3 To our surprise, this tweak—which we like to call the flip-JiTT—ended up completely flipping our classroom. What follows is narrative of our experience and a procedure that any teacher can use to extend JiTT to a flipped classroom.

  14. Just in Time to Flip Your Classroom

    CERN Document Server

    Lasry, Nathaniel; Charles, Elizabeth

    2013-01-01

    With advocates like Sal Khan and Bill Gates, flipped classrooms are attracting an increasing amount of media and research attention. We had heard Khan's TED talk and were aware of the concept of inverted pedagogies in general. Yet, it really hit home when we accidentally flipped our classroom. Our objective was to better prepare our students for class. We set out to effectively move some of our course content outside of class and decided to tweak the Just-in-Time-Teaching approach (JiTT). To our surprise, this tweak - which we like to call the flip-JiTT - ended up completely flipping our classroom. What follows is narrative of our experience and a procedure that any teacher can use to extend JiTT to a flipped classroom.

  15. GRADIENT ENERGY DETECTION OF LSB STEGANOGRAPHY

    Institute of Scientific and Technical Information of China (English)

    Li Zhi; Sui Aifen; Niu Xinxin; Yang Yixian

    2005-01-01

    The spatial Least Significant Bit (LSB) steganography results in the alteration of the smooth characteristics between adjoining pixels of the raw image. The relation between the length of embedded message and the gradient energy is theoretically analyzed, and then a steganalysis and detection method, named Gradient Energy-Flipping Rate (GEFR) detection is proposed. Based on the analysis of the variation of the gradient energy, which results from the LSB steganography in color and grayscale image, the secret message embedded in the target image is detected, and the length of the embedded message is estimated. The method is proved effective and accurate by simulation (detection rate reaches 0.01bit per pixel).

  16. Design of an novel antenna for EBW heating in FLIPS

    Energy Technology Data Exchange (ETDEWEB)

    Rudischhauser, Lukas; Rumiantcev, Kirill; Kasparek, Walter [Institut fuer Grenzflaechenverfahrenstechnik und Plasmatechnologie, Universitaet Stuttgart (Germany)

    2015-05-01

    Electron Bernstein waves (EBW) are electrostatic waves which do not have an O-wave cutoff. This enables them to penetrate into overdense plasmas and be absorbed at multiples of the electron cyclotron resonance frequency. These waves cannot propagate in free space, necessitating generation of EBW within the plasma volume through O-X-B or X-B conversion processes only possible for certain plasma parameters and injection angles. The aim of this work is to design a high directivity antenna which can excite EBW in FLIPS (Flexible Linear Plasma Experiment Stuttgart). We use commercial and scientific software such as CST MS and PROFUSION to produce two designs, a Vlasov-type cut waveguide and a circular slotted waveguide antenna. This second design is to line the inside of the vessel with rotational symmetry, simplifying comparison to numerical results. To find optimal injection angles and polarisations extensive use is made of simulations using a FD3D code and previous work on the plasma configuration in FLIPS. In a first step radiation pattern measurements outside of the plasma will be performed, the antenna will then be installed and generation of EBW indirectly shown by increased heating in the overdense plasma region.

  17. Underfill process development for lead free flip chip assembly

    Science.gov (United States)

    Chaware, Raghunandan

    Underfills are used to enhance the long-term reliability of the flip-chip solder joints. More specifically, the function of the underfill is to couple the chip to the substrate, wherein the shear stresses experienced by the solder joints are converted to bending stresses. The underfill flows under the die due to the influence of strong capillary forces. The flow of the underfill under the chip depends on various factors such as the viscosity of the underfill, contact angle, surface tension, temperature, underfill gap, substrate design, bump pattern, bump density, and size of the chip. The flow of underfill is also influenced by the cleanliness of the substrate, the cleanliness of the underside of the chip, and the flux residues. The interaction between the underfill and the substrate affects not only gap filling, but also the filleting of the underfill. Similarly, the underfill-flux interaction directly affects the quality of underfilling and the reliability of the flip chip assembly. In the case of lead free flip chip assembly, the major concerns vis-a-vis process development for a large chip with a small bump pitch (less than 190 mum) include lower throughput, voiding under the chip, and critical reliability performance. The principal objective of this research endeavor was to investigate the fundamental issues that relate to the process and reliability aspects of underfilling of lead free flip chip assemblies. In order to develop a robust underfilling process, the effect of different process parameters and their interaction with the material properties were studied. In order to improve the compatibility between the underfill and the flux, a new epoxy flux that was compatible with the lead free assembly process was developed. The performance of the epoxy was also compared with the performance of various rosin based fluxes. This study also helped in identifying the critical parameters that can affect the assembly yields. This research endeavor successfully

  18. Flipped classroom: a review of recent literature

    Directory of Open Access Journals (Sweden)

    Huseyin Uzunboylu

    2015-07-01

    Full Text Available The use of learning technologies, especially multimedia provide varied facilities for students’ learning that are not possible with other media. Pedagogical literature has proved that individuals have different learning styles. Flipped classroom is a pedagogical approach which means that activities that have traditionally taken place inside the classroom take place outside the classroom and vice versa. Flipped classroom environment ensures that students become more active participants compared with the traditional classroom. The purpose of this paper is to fulfil the needs regarding the review of recent literature on the use of flipped classroom approach in education. The contribution of flipped classroom to education is discussed in relation to the change of students' and instructors' role. Subsequently, flipped classroom applications in various disciplines of education are illustrated. The recommendations made in the literature for design specifications that integrate flipped classrooms with technology are discussed. The paper concludes that a careful consideration of the warnings and recommendations made in the literature can help to produce effective flipped classroom environments and also this paper attempts to inform those who are thinking of using new technologies and approaches to deliver courses.

  19. FLIPS: Friendly Lisp Image Processing System

    Science.gov (United States)

    Gee, Shirley J.

    1991-08-01

    The Friendly Lisp Image Processing System (FLIPS) is the interface to Advanced Target Detection (ATD), a multi-resolutional image analysis system developed by Hughes in conjunction with the Hughes Research Laboratories. Both menu- and graphics-driven, FLIPS enhances system usability by supporting the interactive nature of research and development. Although much progress has been made, fully automated image understanding technology that is both robust and reliable is not a reality. In situations where highly accurate results are required, skilled human analysts must still verify the findings of these systems. Furthermore, the systems often require processing times several orders of magnitude greater than that needed by veteran personnel to analyze the same image. The purpose of FLIPS is to facilitate the ability of an image analyst to take statistical measurements on digital imagery in a timely fashion, a capability critical in research environments where a large percentage of time is expended in algorithm development. In many cases, this entails minor modifications or code tinkering. Without a well-developed man-machine interface, throughput is unduly constricted. FLIPS provides mechanisms which support rapid prototyping for ATD. This paper examines the ATD/FLIPS system. The philosophy of ATD in addressing image understanding problems is described, and the capabilities of FLIPS are discussed, along with a description of the interaction between ATD and FLIPS. Finally, an overview of current plans for the system is outlined.

  20. Comparing the Effectiveness of Blended, Semi-Flipped, and Flipped Formats in an Engineering Numerical Methods Course

    Science.gov (United States)

    Clark, Renee M.; Kaw, Autar; Besterfield-Sacre, Mary

    2016-01-01

    Blended, flipped, and semi-flipped instructional approaches were used in various sections of a numerical methods course for undergraduate mechanical engineers. During the spring of 2014, a blended approach was used; in the summer of 2014, a combination of blended and flipped instruction was used to deliver a semi-flipped course; and in the fall of…

  1. Small-tip-angle spokes pulse design using interleaved greedy and local optimization methods.

    Science.gov (United States)

    Grissom, William A; Khalighi, Mohammad-Mehdi; Sacolick, Laura I; Rutt, Brian K; Vogel, Mika W

    2012-11-01

    Current spokes pulse design methods can be grouped into methods based either on sparse approximation or on iterative local (gradient descent-based) optimization of the transverse-plane spatial frequency locations visited by the spokes. These two classes of methods have complementary strengths and weaknesses: sparse approximation-based methods perform an efficient search over a large swath of candidate spatial frequency locations but most are incompatible with off-resonance compensation, multifrequency designs, and target phase relaxation, while local methods can accommodate off-resonance and target phase relaxation but are sensitive to initialization and suboptimal local cost function minima. This article introduces a method that interleaves local iterations, which optimize the radiofrequency pulses, target phase patterns, and spatial frequency locations, with a greedy method to choose new locations. Simulations and experiments at 3 and 7 T show that the method consistently produces single- and multifrequency spokes pulses with lower flip angle inhomogeneity compared to current methods.

  2. Twelve tips for "flipping" the classroom.

    Science.gov (United States)

    Moffett, Jennifer

    2015-04-01

    The flipped classroom is a pedagogical model in which the typical lecture and homework elements of a course are reversed. The following tips outline the steps involved in making a successful transition to a flipped classroom approach. The tips are based on the available literature alongside the author's experience of using the approach in a medical education setting. Flipping a classroom has a number of potential benefits, for example increased educator-student interaction, but must be planned and implemented carefully to support effective learning.

  3. Suggestions for Implementing Flipped Classroom in China

    Institute of Scientific and Technical Information of China (English)

    周婷

    2016-01-01

    Educators in the twenty-first century are constantly adopting new technologies and pedagogies. Flipped Classroom Model is one of the most promising approaches to transforming learning experiences, which has been applied to both K-12 edu-cation and higher education at home and abroad. Influenced by culture and learning styles, the effectiveness and concrete imple-mentation strategies of this teaching model is different in different countries. How to localize the model in China is an important question for educators to think about. The paper makes suggestions for implementing Flipped Classroom in China, aiming at helping teachers to flip their classrooms successfully.

  4. Enhancing student engagement using the flipped classroom.

    Science.gov (United States)

    Gilboy, Mary Beth; Heinerichs, Scott; Pazzaglia, Gina

    2015-01-01

    The flipped classroom is an innovative pedagogical approach that focuses on learner-centered instruction. The purposes of this report were to illustrate how to implement the flipped classroom and to describe students' perceptions of this approach within 2 undergraduate nutrition courses. The template provided enables faculty to design before, during, and after class activities and assessments based on objectives using all levels of Bloom's taxonomy. The majority of the 142 students completing the evaluation preferred the flipped method compared with traditional pedagogical strategies. The process described in the report was successful for both faculty and students.

  5. FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP

    Directory of Open Access Journals (Sweden)

    Yuichi Tsuchiya

    2015-12-01

    Full Text Available cFLIP (cellular FLICE-like inhibitory protein is structurally related to caspase-8 but lacks proteolytic activity due to multiple amino acid substitutions of catalytically important residues. cFLIP protein is evolutionarily conserved and expressed as three functionally different isoforms in humans (cFLIPL, cFLIPS, and cFLIPR. cFLIP controls not only the classical death receptor-mediated extrinsic apoptosis pathway, but also the non-conventional pattern recognition receptor-dependent apoptotic pathway. In addition, cFLIP regulates the formation of the death receptor-independent apoptotic platform named the ripoptosome. Moreover, recent studies have revealed that cFLIP is also involved in a non-apoptotic cell death pathway known as programmed necrosis or necroptosis. These functions of cFLIP are strictly controlled in an isoform-, concentration- and tissue-specific manner, and the ubiquitin-proteasome system plays an important role in regulating the stability of cFLIP. In this review, we summarize the current scientific findings from biochemical analyses, cell biological studies, mathematical modeling, and gene-manipulated mice models to illustrate the critical role of cFLIP as a switch to determine the destiny of cells among survival, apoptosis, and necroptosis.

  6. Base flipping in tn10 transposition: an active flip and capture mechanism.

    Directory of Open Access Journals (Sweden)

    Julien Bischerour

    Full Text Available The bacterial Tn5 and Tn10 transposases have a single active site that cuts both strands of DNA at their respective transposon ends. This is achieved using a hairpin intermediate that requires the DNA to change conformation during the reaction. In Tn5 these changes are controlled in part by a flipped nucleoside that is stacked on a tryptophan residue in a hydrophobic pocket of the transposase. Here we have investigated the base flipping mechanism in Tn10 transposition. As in Tn5 transposition, we find that base flipping takes place after the first nick and is required for efficient hairpin formation and resolution. Experiments with an abasic substrate show that the role of base flipping in hairpin formation is to remove the base from the DNA helix. Specific interactions between the flipped base and the stacking tryptophan residue are required for hairpin resolution later in the reaction. We show that base flipping in Tn10 transposition is not a passive reaction in which a spontaneously flipped base is captured and retained by the protein. Rather, it is driven in part by a methionine probe residue that helps to force the flipped base from the base stack. Overall, it appears that base flipping in Tn10 transposition is similar to that in Tn5 transposition.

  7. How we flipped the medical classroom.

    Science.gov (United States)

    Sharma, Neel; Lau, C S; Doherty, Iain; Harbutt, Darren

    2015-04-01

    Flipping the classroom centres on the delivery of print, audio or video based material prior to a lecture or class session. The class session is then dedicated to more active learning processes with application of knowledge through problem solving or case based scenarios. The rationale behind this approach is that teachers can spend their face-to-face time supporting students in deeper learning processes. In this paper we provide a background literature review on the flipped classroom along with a three step approach to flipping the classroom comprising implementing, enacting and evaluating this form of pedagogy. Our three step approach is based on actual experience of delivering a flipped classroom at the University of Hong Kong. This initiative was evaluated with positive results. We hope our experience will be transferable to other medical institutions.

  8. En didaktisk model for Flipped Classroom

    DEFF Research Database (Denmark)

    Levinsen, Henrik; Foss, Kristian Kildemoes; Andersen, Thomas Dyreborg

    2016-01-01

    I artiklen præsenterer vi en model over flipped classroom som didaktisk metode udviklet med henblik på at stilladsere både de lærere, som gerne vil prøve kræfter med en flipped classroom-baseret praksis, og dem som allerede har erfaring, men kan have glæde af at bruge modellen til at kvalificere...... deres flipped classroom-undervisning. Modellen kan bidrage til erkendelsen af, at flipped classroom er noget nær et paradigmeskifte i forståelsen af god undervisning. Her tænkes på det skift i fokus metoden indebærer fra, at læreren er mest aktiv, til at eleverne er de mest aktive. Særligt for den...

  9. Effect of aluminum trace dimension on electro-migration failure in flip-chip package

    Science.gov (United States)

    Liu, Peisheng; Fan, Guangming; Liu, Yahong; Yang, Longlong; Miao, Xiaoyong

    2017-03-01

    A 3D model of flip-chip package is established and thermal-electrical coupling is analyzed. The effect of the width of Aluminum (Al) trace on electro-migration mechanism is also studied. Reducing rates of the hot-spot temperature, the max Joule heating, the max temperature gradient and the max current density are defined to research the effects of the Al trace thickness and the UBM thickness on electro-migration.

  10. Flip to Regular Triangulation and Convex Hull.

    Science.gov (United States)

    Gao, Mingcen; Cao, Thanh-Tung; Tan, Tiow-Seng

    2017-02-01

    Flip is a simple and local operation to transform one triangulation to another. It makes changes only to some neighboring simplices, without considering any attribute or configuration global in nature to the triangulation. Thanks to this characteristic, several flips can be independently applied to different small, non-overlapping regions of one triangulation. Such operation is favored when designing algorithms for data-parallel, massively multithreaded hardware, such as the GPU. However, most existing flip algorithms are designed to be executed sequentially, and usually need some restrictions on the execution order of flips, making them hard to be adapted to parallel computation. In this paper, we present an in depth study of flip algorithms in low dimensions, with the emphasis on the flexibility of their execution order. In particular, we propose a series of provably correct flip algorithms for regular triangulation and convex hull in 2D and 3D, with implementations for both CPUs and GPUs. Our experiment shows that our GPU implementation for constructing these structures from a given point set achieves up to two orders of magnitude of speedup over other popular single-threaded CPU implementation of existing algorithms.

  11. ConfChem Conference on Flipped Classroom: Flipping at an Open-Enrollment College

    Science.gov (United States)

    Butzler, Kelly B.

    2015-01-01

    The flipped classroom is a blended, constructivist learning environment that reverses where students gain and apply knowledge. Instructors from K-12 to the college level are interested in the prospect of flipping their classes, but are unsure how and with which students to implement this learning environment. There has been little discussion…

  12. Research on Flipping College Algebra: Lessons Learned and Practical Advice for Flipping Multiple Sections

    Science.gov (United States)

    Overmyer, Jerry

    2015-01-01

    This quantitative research compares five sections of College Algebra using flipped classroom methods with six sections using the traditional lecture/homework structure and its effect on student achievement as measured through a common final exam. Common final exam scores were the dependent variables. Instructors of flipped sections who had…

  13. Research on Flipping College Algebra: Lessons Learned and Practical Advice for Flipping Multiple Sections

    Science.gov (United States)

    Overmyer, Jerry

    2015-01-01

    This quantitative research compares five sections of College Algebra using flipped classroom methods with six sections using the traditional lecture/homework structure and its effect on student achievement as measured through a common final exam. Common final exam scores were the dependent variables. Instructors of flipped sections who had…

  14. Flip-chip integration of tilted VCSELs onto a silicon photonic integrated circuit.

    Science.gov (United States)

    Lu, Huihui; Lee, Jun Su; Zhao, Yan; Scarcella, Carmelo; Cardile, Paolo; Daly, Aidan; Ortsiefer, Markus; Carroll, Lee; O'Brien, Peter

    2016-07-25

    In this article we describe a cost-effective approach for hybrid laser integration, in which vertical cavity surface emitting lasers (VCSELs) are passively-aligned and flip-chip bonded to a Si photonic integrated circuit (PIC), with a tilt-angle optimized for optical-insertion into standard grating-couplers. A tilt-angle of 10° is achieved by controlling the reflow of the solder ball deposition used for the electrical-contacting and mechanical-bonding of the VCSEL to the PIC. After flip-chip integration, the VCSEL-to-PIC insertion loss is -11.8 dB, indicating an excess coupling penalty of -5.9 dB, compared to Fibre-to-PIC coupling. Finite difference time domain simulations indicate that the penalty arises from the relatively poor match between the VCSEL mode and the grating-coupler.

  15. An analysis of the uncertainty and bias in DCE-MRI measurements using the spoiled gradient-recalled echo pulse sequence

    Energy Technology Data Exchange (ETDEWEB)

    Subashi, Ergys [Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina 27710 and Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27710 (United States); Choudhury, Kingshuk R. [Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27710 (United States); Johnson, G. Allan, E-mail: gjohnson@duke.edu [Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina 27710 (United States); Medical Physics Graduate Program, Duke University Medical Center, Durham, North Carolina 27710 (United States); Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27710 (United States); Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710 (United States)

    2014-03-15

    Purpose: The pharmacokinetic parameters derived from dynamic contrast-enhanced (DCE) MRI have been used in more than 100 phase I trials and investigator led studies. A comparison of the absolute values of these quantities requires an estimation of their respective probability distribution function (PDF). The statistical variation of the DCE-MRI measurement is analyzed by considering the fundamental sources of error in the MR signal intensity acquired with the spoiled gradient-echo (SPGR) pulse sequence. Methods: The variance in the SPGR signal intensity arises from quadrature detection and excitation flip angle inconsistency. The noise power was measured in 11 phantoms of contrast agent concentration in the range [0–1] mM (in steps of 0.1 mM) and in onein vivo acquisition of a tumor-bearing mouse. The distribution of the flip angle was determined in a uniform 10 mM CuSO{sub 4} phantom using the spin echo double angle method. The PDF of a wide range of T1 values measured with the varying flip angle (VFA) technique was estimated through numerical simulations of the SPGR equation. The resultant uncertainty in contrast agent concentration was incorporated in the most common model of tracer exchange kinetics and the PDF of the derived pharmacokinetic parameters was studied numerically. Results: The VFA method is an unbiased technique for measuringT1 only in the absence of bias in excitation flip angle. The time-dependent concentration of the contrast agent measured in vivo is within the theoretically predicted uncertainty. The uncertainty in measuring K{sup trans} with SPGR pulse sequences is of the same order, but always higher than, the uncertainty in measuring the pre-injection longitudinal relaxation time (T1{sub 0}). The lowest achievable bias/uncertainty in estimating this parameter is approximately 20%–70% higher than the bias/uncertainty in the measurement of the pre-injection T1 map. The fractional volume parameters derived from the extended Tofts model

  16. Analytic derivative couplings for spin-flip configuration interaction singles and spin-flip time-dependent density functional theory.

    Science.gov (United States)

    Zhang, Xing; Herbert, John M

    2014-08-14

    We revisit the calculation of analytic derivative couplings for configuration interaction singles (CIS), and derive and implement these couplings for its spin-flip variant for the first time. Our algorithm is closely related to the CIS analytic energy gradient algorithm and should be straightforward to implement in any quantum chemistry code that has CIS analytic energy gradients. The additional cost of evaluating the derivative couplings is small in comparison to the cost of evaluating the gradients for the two electronic states in question. Incorporation of an exchange-correlation term provides an ad hoc extension of this formalism to time-dependent density functional theory within the Tamm-Dancoff approximation, without the need to invoke quadratic response theory or evaluate third derivatives of the exchange-correlation functional. Application to several different conical intersections in ethylene demonstrates that minimum-energy crossing points along conical seams can be located at substantially reduced cost when analytic derivative couplings are employed, as compared to use of a branching-plane updating algorithm that does not require these couplings. Application to H3 near its D(3h) geometry demonstrates that correct topology is obtained in the vicinity of a conical intersection involving a degenerate ground state.

  17. Development of gold based solder candidates for flip chip assembly

    DEFF Research Database (Denmark)

    Chidambaram, Vivek; Hald, John; Hattel, Jesper Henri

    2009-01-01

    Flip chip technology is now rapidly replacing the traditional wire bonding interconnection technology in the first level packaging applications due to the miniaturization drive in the microelectronics industry. Flip chip assembly currently involves the use of high lead containing solders for inte......Flip chip technology is now rapidly replacing the traditional wire bonding interconnection technology in the first level packaging applications due to the miniaturization drive in the microelectronics industry. Flip chip assembly currently involves the use of high lead containing solders...

  18. Use of Flipped Classroom Technology in Language Learning

    OpenAIRE

    Evseeva, Arina; Solozhenko, Anton

    2015-01-01

    The flipped classroom as a key component of blended learning arouses great interest among researchers and educators nowadays. The technology of flipped classroom implies such organization of the educational process in which classroom activities and homework assignments are reversed. The present paper gives the overview of the flipped classroom technology and explores its potential for both teachers and students. The authors present the results obtained from the experience of the flipped class...

  19. Bridging the gap with flipped classroom

    DEFF Research Database (Denmark)

    Selberg, Hanne; Topperzer, Martha

    2016-01-01

    Bridging the gap with flipped classroom Hanne Selberg, Metropolitan University College, Copenhagen, Martha Topperzer, University Hospital Rigshospitalet, Copenhagen, Denmark Background and aims Consistent with the strategy of increasing digitization and learner-centred teaching models...... in the nursing curriculum, we have reversed selected traditional lectures into simulation based teaching activities embedded in a ten week Pediatric Nursing module for third year nursing students. The current pilot study seeks to explore the impact on students’ learning and commitment when flipping the classroom...... using educational technologies such as online preparation contents and simulation based scenarios. Furthermore, the objective is to enhance theory-practice integration in the educational setting. Materials & Methods The flipped classroom model replaces three theoretical lectures addressing disease...

  20. Flipping the statistics classroom in nursing education.

    Science.gov (United States)

    Schwartz, Todd A

    2014-04-01

    Flipped classrooms are so named because they substitute the traditional lecture that commonly encompasses the entire class period with active learning techniques, such as small-group work. The lectures are delivered instead by using an alternative mode--video recordings--that are made available for viewing online outside the class period. Due to this inverted approach, students are engaged with the course material during the class period, rather than participating only passively. This flipped approach is gaining popularity in many areas of education due to its enhancement of student learning and represents an opportunity for utilization by instructors of statistics courses in nursing education. This article presents the author's recent experiences with flipping a statistics course for nursing students in a PhD program, including practical considerations and student outcomes and reaction. This transformative experience deepened the level of student learning in a way that may not have occurred using a traditional format.

  1. Experimental plug and play quantum coin flipping

    Science.gov (United States)

    Pappa, Anna; Jouguet, Paul; Lawson, Thomas; Chailloux, André; Legré, Matthieu; Trinkler, Patrick; Kerenidis, Iordanis; Diamanti, Eleni

    2014-04-01

    Performing complex cryptographic tasks will be an essential element in future quantum communication networks. These tasks are based on a handful of fundamental primitives, such as coin flipping, where two distrustful parties wish to agree on a randomly generated bit. Although it is known that quantum versions of these primitives can offer information-theoretic security advantages with respect to classical protocols, a demonstration of such an advantage in a practical communication scenario has remained elusive. Here we experimentally implement a quantum coin flipping protocol that performs strictly better than classically possible over a distance suitable for communication over metropolitan area optical networks. The implementation is based on a practical plug and play system, developed by significantly enhancing a commercial quantum key distribution device. Moreover, we provide combined quantum coin flipping protocols that are almost perfectly secure against bounded adversaries. Our results offer a useful toolbox for future secure quantum communications.

  2. Stochastic Flips on Two-letter Words

    CERN Document Server

    Bodini, Olivier; Regnault, Damien

    2010-01-01

    This paper introduces a simple Markov process inspired by the problem of quasicrystal growth. It acts over two-letter words by randomly performing \\emph{flips}, a local transformation which exchanges two consecutive different letters. More precisely, only the flips which do not increase the number of pairs of consecutive identical letters are allowed. Fixed-points of such a process thus perfectly alternate different letters. We show that the expected number of flips to converge towards a fixed-point is bounded by $O(n^3)$ in the worst-case and by $O(n^{5/2}\\ln{n})$ in the average-case, where $n$ denotes the length of the initial word.

  3. Coding Education in a Flipped Classroom

    Directory of Open Access Journals (Sweden)

    Vasfi Tugun

    2017-08-01

    Full Text Available The main purpose of this research is to determine the influence of the flipped classroom model on digital game development and student views on the model. 9th grade students attending Bilişim Teknolojiler II at secondary level participated in the study. The research is an experimental research, designed according to the pretest-posttest research model with experimental and control groups. In the experimental group, the lectures were carried out according to the flipped classroom model while the control group was taught with the traditional methods in the laboratory environment. As a result of the research, the success of the digital game development and the opinions of the students were favored by the experimental group students who were educated with the flipped classroom model. The results obtained in the last part of the study and suggestions for the results are discussed.

  4. The flipped classroom: strategies for an undergraduate nursing course.

    Science.gov (United States)

    Schlairet, Maura C; Green, Rebecca; Benton, Melissa J

    2014-01-01

    This article presents the authors' experience with flipping a fundamental concepts of nursing course for students in an undergraduate baccalaureate program. Authors describe implementing a flipped class, practical strategies to transform students' learning experience, and lessons learned. This article serves as a guide to faculty and programs seeking to develop and implement the flipped class model in nursing education.

  5. Impacts of Flipped Classroom in High School Health Education

    Science.gov (United States)

    Chen, Li-Ling

    2016-01-01

    As advanced technology increasingly infiltrated into classroom, the flipped classroom has come to light in secondary educational settings. The flipped classroom is a new instructional approach that intends to flip the traditional teacher-centered classroom into student centered. The purpose of this research is to investigate the impact of the…

  6. Deep Exploration of the Flipped Classroom before Implementing

    Science.gov (United States)

    Logan, Brenda

    2015-01-01

    This paper is a review of the literature that attempts to explain and document the literature on the flipped classroom. It examines 49 studies that explain the flipped approach in the classroom. This paper, particularly, delineates the history, the theory, benefits, criticisms, recommended practices, and what the research on flipping reveals.…

  7. Advanced Flip Chips in Extreme Temperature Environments

    Science.gov (United States)

    Ramesham, Rajeshuni

    2010-01-01

    The use of underfill materials is necessary with flip-chip interconnect technology to redistribute stresses due to mismatching coefficients of thermal expansion (CTEs) between dissimilar materials in the overall assembly. Underfills are formulated using organic polymers and possibly inorganic filler materials. There are a few ways to apply the underfills with flip-chip technology. Traditional capillary-flow underfill materials now possess high flow speed and reduced time to cure, but they still require additional processing steps beyond the typical surface-mount technology (SMT) assembly process. Studies were conducted using underfills in a temperature range of -190 to 85 C, which resulted in an increase of reliability by one to two orders of magnitude. Thermal shock of the flip-chip test articles was designed to induce failures at the interconnect sites (-40 to 100 C). The study on the reliability of flip chips using underfills in the extreme temperature region is of significant value for space applications. This technology is considered as an enabling technology for future space missions. Flip-chip interconnect technology is an advanced electrical interconnection approach where the silicon die or chip is electrically connected, face down, to the substrate by reflowing solder bumps on area-array metallized terminals on the die to matching footprints of solder-wettable pads on the chosen substrate. This advanced flip-chip interconnect technology will significantly improve the performance of high-speed systems, productivity enhancement over manual wire bonding, self-alignment during die joining, low lead inductances, and reduced need for attachment of precious metals. The use of commercially developed no-flow fluxing underfills provides a means of reducing the processing steps employed in the traditional capillary flow methods to enhance SMT compatibility. Reliability of flip chips may be significantly increased by matching/tailoring the CTEs of the substrate

  8. Blended Course with Flipped Classroom Approach

    DEFF Research Database (Denmark)

    Timcenko, Olga; Purwins, Hendrik; Triantafyllou, Evangelia

    2015-01-01

    This paper presents and analyses design decisions and development process of producing teaching materials for a blended course with flipped classroom approach at bachelor level at Aalborg University in Copenhagen, Denmark. Our experiences, as well as students’ reactions and opinions will be descr......This paper presents and analyses design decisions and development process of producing teaching materials for a blended course with flipped classroom approach at bachelor level at Aalborg University in Copenhagen, Denmark. Our experiences, as well as students’ reactions and opinions...

  9. Revisiting fermion helicity flip in Podolsky's Electromagnetism

    CERN Document Server

    Sales, Jorge Henrique; Thibes, Ronaldo

    2016-01-01

    The spin projection of a massive particle onto its direction of motion is called helicity (or "handedness"). It can therefore be positive or negative. When a particle's helicity changes from positive to negative (or vice-versa) due to its interaction with other particles or fields, we say there is a helicity flip. In this work we show that such helicity flip can be seen for an electron of $20 MeV$ of energy interacting with a charged scalar meson through the exchange of a virtual photon. This photon {\\it does not} necessarily need to be Podolsky's proposed photon; in fact, it is independent of it.

  10. Magnetization transfer prepared gradient echo MRI for CEST imaging.

    Directory of Open Access Journals (Sweden)

    Zhuozhi Dai

    Full Text Available Chemical exchange saturation transfer (CEST is an emerging MRI contrast mechanism that is capable of noninvasively imaging dilute CEST agents and local properties such as pH and temperature, augmenting the routine MRI methods. However, the routine CEST MRI includes a long RF saturation pulse followed by fast image readout, which is associated with high specific absorption rate and limited spatial resolution. In addition, echo planar imaging (EPI-based fast image readout is prone to image distortion, particularly severe at high field. To address these limitations, we evaluated magnetization transfer (MT prepared gradient echo (GRE MRI for CEST imaging. We proved the feasibility using numerical simulations and experiments in vitro and in vivo. Then we optimized the sequence by serially evaluating the effects of the number of saturation steps, MT saturation power (B1, GRE readout flip angle (FA, and repetition time (TR upon the CEST MRI, and further demonstrated the endogenous amide proton CEST imaging in rats brains (n = 5 that underwent permanent middle cerebral artery occlusion. The CEST images can identify ischemic lesions in the first 3 hours after occlusion. In summary, our study demonstrated that the readily available MT-prepared GRE MRI, if optimized, is CEST-sensitive and remains promising for translational CEST imaging.

  11. Flip-chip-type high-Tc gradiometer for biomagnetic measurements in unshielded environment

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    A flip-chip-type gradiometer has been constructed with a 10 mm×5 mm planar DC-SQUID gradiometer fabricated on a SrTiO3 bicrystal substrate and a flux transformer made from a YBCO*/YBCO/CeO2/YSZ multilayer on a φ50.8 mm Si wafer. The coupling coefficient between the flux transformer and the planar gradiometer is 0.18. The transformer increases effectively the resolution of the gradiometer. A magnetic field gradient resolution of 73 fT·cm-1·Hz-1/2 in the white region and 596 fT·cm-1Hz-1/2 at 1 Hz has been obtained. High quality magnetocardiogram signals have been successfully measured by using this flip-chip-type gradiometer in an unshielded environment.

  12. Flip-chip-type high- T_c gradiometer for biomagnetic measurements in unshielded environment

    Institute of Scientific and Technical Information of China (English)

    田永君; 王天生; 陈珂; 漆汉宏; 陈烈; 郑东宁; Sven; LINZEN; Frank; SCHMIDL; Paul; SEIDEL

    2000-01-01

    A flip-chip-type gradiometer has been constructed with a 10 mm × 5 mm planar DC-SQUID gradiometer fabricated on a SrTiO3 bicrystal substrate and a flux transformer made from a YB-CO* /YBCO/CeO2/YSZ multilayer on a φ50.8 mm Si wafer. The coupling coefficient between the flux transformer and the planar gradiometer is 0.18. The transformer increases effectively the resolution of the gradiometer. A magnetic field gradient resolution of 73 fT·cm-1·Hz-1/2 in the white region and 596 fT·cm-1Hz-1/2 at 1 Hz has been obtained. High quality magnetocardiogram signals have been successfully measured by using this flip-chip-type gradiometer in an unshielded environment.

  13. CODIMENSION 3 BIFURCATIONS OF HOMOCLINIC ORBITS WITH ORBIT FLIPS AND INCLINATION FLIPS

    Institute of Scientific and Technical Information of China (English)

    SHUI SHULIANG; ZHU DEMING

    2004-01-01

    The homoclinic bifurcations in four dimensional vector fields are investigated by setting up a local coordinates near the homoclinic orbit. This homoclinic orbit is nonprincipal in the meanings that its positive semi-orbit takes orbit flip and its unstable foliation takes inclination flip. The existence, nonexistence, uniqueness and coexistence of the 1-homoclinic orbit and the 1-periodic orbit are studied. The existence of the twofold periodic orbit and three-fold periodic orbit are also obtained.

  14. Performance and Perception in the Flipped Classroom

    Science.gov (United States)

    Blair, Erik; Maharaj, Chris; Primus, Simone

    2016-01-01

    Changes in the conceptualisation of higher education have led to instructional methods that embrace technology as a teaching medium. These changes have led to the flipped classroom phenomenon--where content is delivered outside class, through media such as video and podcast, and engagement with the content, through problem-solving and/or group…

  15. The Flipped Classroom in World History

    Science.gov (United States)

    Gaughan, Judy E.

    2014-01-01

    The flipped Classroom is one in which lectures are presented as homework outside of class in online videos so that class time is reserved for engaging directly with the materials. This technique offers more personalized guidance and interaction with students, instead of lecturing. In this article, Judy Gaughan details her journey through choosing…

  16. Flipped Classrooms for Advanced Science Courses

    Science.gov (United States)

    Tomory, Annette; Watson, Sunnie Lee

    2015-01-01

    This article explains how issues regarding dual credit and Advanced Placement high school science courses could be mitigated via a flipped classroom instructional model. The need for advanced high school courses will be examined initially, followed by an analysis of advanced science courses and the reform they are experiencing. Finally, it will…

  17. Exploring Flipped Classroom Instruction in Calculus III

    Science.gov (United States)

    Wasserman, Nicholas H.; Quint, Christa; Norris, Scott A.; Carr, Thomas

    2017-01-01

    In an undergraduate Calculus III class, we explore the effect of "flipping" the instructional delivery of content on both student performance and student perceptions. Two instructors collaborated to determine daily lecture notes, assigned the same homework problems, and gave identical exams; however, compared to a more traditional…

  18. 6 Expert Tips for Flipping the Classroom

    Science.gov (United States)

    Demski, Jennifer

    2013-01-01

    In a flipped classroom, professors assign pre-class homework consisting of brief, recorded lectures and presentations, digital readings with collaborative annotation capabilities, and discussion board participation. This frees up classroom time to promote active learning through collaborative, project-based activities using simple display and…

  19. Exploring Flipped Classroom Instruction in Calculus III

    Science.gov (United States)

    Wasserman, Nicholas H.; Quint, Christa; Norris, Scott A.; Carr, Thomas

    2017-01-01

    In an undergraduate Calculus III class, we explore the effect of "flipping" the instructional delivery of content on both student performance and student perceptions. Two instructors collaborated to determine daily lecture notes, assigned the same homework problems, and gave identical exams; however, compared to a more traditional…

  20. Flip-OFDM for Unipolar Communication Systems

    CERN Document Server

    Fernando, Nirmal; Viterbo, Emanuele

    2011-01-01

    Unipolar communications systems can transmit information using only real and positive signals. This includes a variety of physical channels ranging from optical (fiber or free-space), to RF wireless using amplitude modulation with non-coherent reception, to baseband single wire communications. Unipolar OFDM techniques enable to efficiently compensate frequency selective distortion in the unipolar communication systems. One of the leading examples of unipolar OFDM is asymmetric clipped optical OFDM (ACO-OFDM) originally proposed for optical communications. Flip-OFDM is an alternative approach that was proposed in a patent, but its performance and full potentials have never been investigated in the literature. In this paper, we first compare Flip-OFDM and ACO-OFDM, and show that both techniques have the same performance but different complexities (Flip-OFDM offers 50% saving). We then propose a new detection scheme, which enables to reduce the noise at the Flip-OFDM receiver by almost 3dB. The analytical perfor...

  1. Flipping an Agricultural Education Teaching Methods Course

    Science.gov (United States)

    Conner, Nathan W.; Stripling, Christopher T.; Blythe, Jessica M.; Roberts, T. Grady; Stedman, Nicole L. P.

    2014-01-01

    Flipping or inverting a course is a relatively new approach to structuring a course. Using this method, the lectures traditionally delivered during regularly scheduled class time are converted to a media for delivery online, often in the form of videos. Learners are expected to view the online lectures prior to class. Then in turn, in-class time…

  2. Using lightboard to flip the course

    DEFF Research Database (Denmark)

    Timcenko, Olga; Triantafyllou, Evangelia; Nilsson, Niels Chr.

    , and exercises for in-class work. However, the quality of videos that students have to watch before coming to the class is also important. In this paper, we will describe videos prepared for flipped classroom using light board, an invention from 2014. That allows natural flow of presentation, as it combines...

  3. Flip-flops of FK Comae Berenices

    DEFF Research Database (Denmark)

    Hackman, T.; Mantere, M.J.; Jetsu, L.

    2013-01-01

    -2010. The observations were carried out with two automated photometric telescopes, Phoenix-10 and Amadeus T7 located in Arizona. Results. We identify complex phase behaviour in 6 of the 15 analysed data segments. We identify five flip-flop events and two cases of phase jumps, where the phase shift is ¿f

  4. High tip angle approximation based on a modified Bloch-Riccati equation.

    Science.gov (United States)

    Boulant, Nicolas; Hoult, David I

    2012-02-01

    When designing a radio-frequency pulse to produce a desired dependence of magnetization on frequency or position, the small flip angle approximation is often used as a first step, and a Fourier relation between pulse and transverse magnetization is then invoked. However, common intuition often leads to linear scaling of the resulting pulse so as to produce a larger flip angle than the approximation warrants--with surprisingly good results. Starting from a modified version of the Bloch-Riccati equation, a differential equation in the flip angle itself, rather than in magnetization, is derived. As this equation has a substantial linear component that is an instance of Fourier's equation, the intuitive approach is seen to be justified. Examples of the accuracy of this higher tip angle approximation are given for both constant- and variable-phase pulses.

  5. Gradient networks

    Science.gov (United States)

    Toroczkai, Zoltán; Kozma, Balázs; Bassler, Kevin E.; Hengartner, N. W.; Korniss, G.

    2008-04-01

    Gradient networks are defined (Toroczkai and Bassler 2004 Nature 428 716) as directed graphs formed by local gradients of a scalar field distributed on the nodes of a substrate network G. We present the derivation for some of the general properties of gradient graphs and give an exact expression for the in-degree distribution R(l) of the gradient network when the substrate is a binomial (Erd{\\;\\kern -0.10em \\raise -0.35ex \\{{^{^{\\prime\\prime}}}}\\kern -0.57em \\o} s-Rényi) random graph, G_{N,p} , and the scalars are independent identically distributed (i.i.d.) random variables. We show that in the limit N \\to \\infty, p \\to 0, z = pN = \\mbox{const} \\gg 1, R(l)\\propto l^{-1} for l Bassler (2004 Nature 428 716).

  6. Toggling bistable atoms via mechanical switching of bond angle.

    Science.gov (United States)

    Sweetman, Adam; Jarvis, Sam; Danza, Rosanna; Bamidele, Joseph; Gangopadhyay, Subhashis; Shaw, Gordon A; Kantorovich, Lev; Moriarty, Philip

    2011-04-01

    We reversibly switch the state of a bistable atom by direct mechanical manipulation of bond angle using a dynamic force microscope. Individual buckled dimers at the Si(100) surface are flipped via the formation of a single covalent bond, actuating the smallest conceivable in-plane toggle switch (two atoms) via chemical force alone. The response of a given dimer to a flip event depends critically on both the local and nonlocal environment of the target atom-an important consideration for future atomic scale fabrication strategies.

  7. Reversal of Magnetisation in Ising Ferromagnet by the Field Having Gradient

    Science.gov (United States)

    Dhar, Abyaya; Acharyya, Muktish

    2016-11-01

    We have studied the reversal of magnetisation in Ising ferromagnet by the field having gradient along a particular direction. We employed the Monte Carlo simulation with Metropolis single spin flip algorithm. The average lifetime of the metastable state was observed to increase with the magnitude of the gradient of applied field. In the high gradient regime, the system was observed to show two distinct region of up and down spins. The interface or the domain wall was observed to move as one increases the gradient. The displacement of the mean position of the interface was observed to increase with the gradient as hyperbolic tangent function. The roughness of the interface was observed to decay exponentially as the gradient increases. The number of spin flip per site was observed to show a discontinuity in the vicinity of the domain wall. The amount of the discontinuity was found to diverge with the system size as a power law fashion with an exponent 5/3.

  8. Research on a Micro Flip Robot That Can Climb Stairs

    Directory of Open Access Journals (Sweden)

    Jianzhong Wang

    2016-03-01

    Full Text Available Micro mobile robots (MMRs can operate in rugged, narrow or dangerous regions; thus, they are widely used in numerous areas including surveillance, rescue and exploration. In urban environments, stairs are common obstacles, ones that such robots find difficult to manoeuvre over. The authors analysed the research status of MMRs, particularly in terms of difficulties when performing stair climbing and present a novel type of MMR called the micro flip robot (MFRobot. A support arm subassembly was added to the centre of a wheeled chassis; using this structure, the MFRobot can climb stairs when a flipping mode is utilized. Based on this structure, the authors established a kinematic model of the stair-climbing process and analysed the force conditions for the key status, contributing to the existing knowledge of robot design. An MFRobot prototype was produced and the stair-climbing experiments, as well as experiments on manoeuvring through rubble regions and slope surfaces, were conducted. The results show that the MFRobot can rapidly climb common stairs and can easily manoeuvre through a rubble region. The maximum slope angle the robot can climb was shown to be about 35° for concrete and wooden slope surfaces. In the case where the robot needed to be equipped with sensors, particularly a camera, the camera was equipped on the support arm of robot. The MFRobot prototype weighs 2.5 kg and is easily transportable. This structure can resolve contradictions between portability and performance in terms of overcoming obstacles; in addition, operational effectiveness can be improved using this structure.

  9. ANALYSIS ON INCLINATION ANGLE OF SHEAR BAND UNDER LOW CONFINING PRESSURE BASED ON GRADIENT-DEPENDENT PLASTICITY%围压对剪切带倾角影响的梯度塑性理论分析

    Institute of Scientific and Technical Information of China (English)

    王学滨; 姚再兴; 潘一山

    2004-01-01

    The inclination angle of shear band is analyzed considering heterogeneity of rock material when a single shear band is formed in the center of specimen under triaxial compression. The analytical solution of post-peak axial stress-axial strain curve is deduced using the assumption that the total post-peak deformation is composed of entire uniform elastic deformation and localized shear plastic deformation dependent on the thickness of shear band. The obtained solution shows that the post-peak stiffness is related to the inclination angle of shear band,confining pressure,thickness of shear band and elastic modulus,etc. Using the solution,the expression for the inclination angle of shear band can be presented easily and it is dependent on constitutive parameters of rock material and geometry parameters of rock specimen. Larger dilation angle or loading rate leads to increment of the inclination angle. In addition,the inclination angle increases with the thickness of the shear band,which cannot be explained or forecasted by other existing solutions,such as Coulomb inclination,Roscoe inclination and Arthur inclination,etc.

  10. Using a SPOC to flip the classroom

    OpenAIRE

    Martínez-Muñoz, Gonzalo; Pulido, Estrella

    2015-01-01

    Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. G. Martínez-Muñoz and E. Pulido, "Using a SPOC to flip the classroom," 2015 IEEE Global Engineering Education Conference (EDUC...

  11. 2-bit Flip Mutation Elementary Fitness Landscapes

    OpenAIRE

    Langdon, William

    2010-01-01

    Genetic Programming parity is not elementary. GP parity cannot be represented as the sum of a small number of elementary landscapes. Statistics, including fitness distance correlation, of Parity's fitness landscape are calculated. Using Walsh analysis the eigen values and eigenvectors of the Laplacian of the two bit flip fitness landscape are given and a ruggedness measure for elementary landscapes is proposed. An elementary needle in a haystack (NIH) landscape is g...

  12. Assessment of learning gains in a flipped biochemistry classroom.

    Science.gov (United States)

    Ojennus, Deanna Dahlke

    2016-01-01

    The flipped classroom has become an increasingly popular pedagogical approach to teaching and learning. In this study, learning gains were assessed in a flipped biochemistry course and compared to gains in a traditional lecture. Although measured learning gains were not significantly different between the two courses, student perception of learning gains did differ and indicates a higher level of satisfaction with the flipped lecture format. © 2015 The International Union of Biochemistry and Molecular Biology.

  13. Student experiences across multiple flipped courses in a single curriculum.

    Science.gov (United States)

    Khanova, Julia; Roth, Mary T; Rodgers, Jo Ellen; McLaughlin, Jacqueline E

    2015-10-01

    The flipped classroom approach has garnered significant attention in health professions education, which has resulted in calls for curriculum-wide implementations of the model. However, research to support the development of evidence-based guidelines for large-scale flipped classroom implementations is lacking. This study was designed to examine how students experience the flipped classroom model of learning in multiple courses within a single curriculum, as well as to identify specific elements of flipped learning that students perceive as beneficial or challenging. A qualitative analysis of students' comments (n = 6010) from mid-course and end-of-course evaluations of 10 flipped courses (in 2012-2014) was conducted. Common and recurring themes were identified through systematic iterative coding and sorting using the constant comparison method. Multiple coders, agreement through consensus and member checking were utilised to ensure the trustworthiness of findings. Several themes emerged from the analysis: (i) the perceived advantages of flipped learning coupled with concerns about implementation; (ii) the benefits of pre-class learning and factors that negatively affect these benefits, such as quality and quantity of learning materials, as well as overall increase in workload, especially in the context of multiple concurrent flipped courses; (iii) the role of the instructor in the flipped learning environment, particularly in engaging students in active learning and ensuring instructional alignment, and (iv) the need for assessments that emphasise the application of knowledge and critical thinking skills. Analysis of data from 10 flipped courses provided insight into common patterns of student learning experiences specific to the flipped learning model within a single curriculum. The study points to the challenges associated with scaling the implementation of the flipped classroom across multiple courses. Several core elements critical to the effective design

  14. The flipped classroom: practices and opportunities for health sciences librarians.

    Science.gov (United States)

    Youngkin, C Andrew

    2014-01-01

    The "flipped classroom" instructional model is being introduced into medical and health sciences curricula to provide greater efficiency in curriculum delivery and produce greater opportunity for in-depth class discussion and problem solving among participants. As educators employ the flipped classroom to invert curriculum delivery and enhance learning, health sciences librarians are also starting to explore the flipped classroom model for library instruction. This article discusses how academic and health sciences librarians are using the flipped classroom and suggests opportunities for this model to be further explored for library services.

  15. Characterisation of hybrid integrated all-optical flip-flop

    DEFF Research Database (Denmark)

    Liu, Y.; McDougall, R.; Seoane, Jorge

    2006-01-01

    We present a fully-packaged, hybrid-integrated all-optical flip-flop with separate optical set and reset operation. The flip-flop can control a wavelength converter to route 40 Gb/s data packets all-optically. The experimental results are given.......We present a fully-packaged, hybrid-integrated all-optical flip-flop with separate optical set and reset operation. The flip-flop can control a wavelength converter to route 40 Gb/s data packets all-optically. The experimental results are given....

  16. Immunohistopathological Study of c-FLIP Protein in Mycosis Fungoides

    Science.gov (United States)

    Rezk Hassan, Ghada Fawzy; Marey, Karima

    2017-09-27

    Background: Mycosis fungoides (MF) is the commonest variant of primary cutaneous T cell lymphoma with several clinicopathologic variants. Defective apoptotic mechanism may be important in the pathogenesis and progression of MF. c-FLIP protein is an important anti-apoptotic marker and chemotherapeutic resistant factor. This study aimed to evaluate the c-FLIP expression in MF and its role in the pathogenesis of MF. Methods: Twenty patients of MF and ten normal persons were included in this study. Skin biopsies were obtained from both patients and controls. They were studied and examined immunohistochemically for the expression of CD4 and c-FLIP. Results: c-FLIP expression was significantly increased in patients when compared to controls in both epidermis and dermis. There were positive correlations between c-FLIP expression and CD4+ expression in both epidermal and dermal lesions of patients group. There were statistically significant positive correlations between c-FLIP expression (in both dermal and epidermal lesions) and the age of patients. c-FLIP expression increased with the tumor progression but with no statistical significance. Conclusion: Defective regulation of apoptosis has been considered as a main cause for accumulation of clonal T cells, and it was related to an increased expression of c-FLIP which may have a role in the pathogenesis of MF. Also, c-FLIP may have prognostic information in MF as its level increased with both age of the patients and tumor progression. Creative Commons Attribution License

  17. Flipped classroom model for learning evidence-based medicine

    National Research Council Canada - National Science Library

    Rucker SY; Ozdogan Z; Al Achkar M

    2017-01-01

    .... A flipped classroom model appears to be an ideal strategy to meet the demands to connect evidence to practice while creating engaged, culturally competent, and technologically literate physicians...

  18. STUDY ON A HYDROPHOBIC-HYDROPHILIC GRADIENT ROD

    Institute of Scientific and Technical Information of China (English)

    Jun Ma; Bai-yu Li; Hai-yun Liu; Zhi-min Zheng; Jian Xu

    2004-01-01

    A hydrophobic-hydrophilic gradient rod with a length of 40 mm and a diameter of 3 mm was prepared by heating a polymethylsilsesquioxane rod in a cylindrical stove with temperature gradient. The rod was thus pyrolyzed under a temperature gradient condition. The organic end of the gradient rod appears hydrophobic with a contact angle of 109.9° while the other end is hydrophilic with a contact angle of 62.4°. The gradient chemical structure and the gradient microstructure along the rod were characterized by FTIR and SEM, respectively.

  19. Flip or Flop? Students' Perspectives of a Flipped Lecture in Mathematics

    Science.gov (United States)

    Novak, Julia; Kensington-Miller, Barbara; Evans, Tanya

    2017-01-01

    This paper describes students' perspectives of a one-off flipped lecture in a large undergraduate mathematics service course. The focus was on calculating matrix determinants and was designed specifically to introduce debate and argumentation into a mathematics lecture. The intention was to promote a deeper learning and understanding through…

  20. The effects of specific drills on the flip turns of freestyle swimmers based on a kinesiology analysis.

    Science.gov (United States)

    Wen, Yuhong; Peng, Yi; Zhao, Feng; Zhen, Kexin

    2016-09-01

    This research aimed to define the key factors in freestyle flip turns via a kinesiology analysis to diagnose swimmers. Hence, specially designed drills were created to improve swimmers' flip-turn skills and assess the effects of training. Nine Chinese national modern pentathlon athletes ranging in age from 20 to 26 years with an average of 10 years of training experience were tested and trained in this study. The Kistler Performance Analysis System for Swimming was used for the pre- and post-test analyses. A kinesiology analysis of the data from the pre-test was used for the diagnosis and specific drills were adopted for 10 weeks, 3 times per week before the post-test. The comparison of the pre- and post-test performances was used to assess the effects of training. After 10 weeks of specific drill training for flip turns, participants' turning skills significantly improved. Speed in approaching, somersaulting, pushing-off and gliding all increased. The angles of the knees and hips as well as the force applied improved, which contributed to swimmers' increased speed. Since the skills needed for a flip turn are complex and not easily diagnosed via observation alone, this kinesiology analysis will make diagnosis objective and easy.

  1. Students, Parents Give Thumbs-Up to Flipped Classroom

    Science.gov (United States)

    Pearson, George

    2012-01-01

    The Flipped Classroom isn't for everyone, but it's been well received by Math and Biology students and their parents at Okanagan Mission Secondary School (OKM) in Kelowna, B.C., and was strongly supported by the OKM principal, Scott Mclean. As teacher Graham Johnson noted in his personal account of his first year using the Flipped Classroom…

  2. Case Study: Case Studies and the Flipped Classroom

    Science.gov (United States)

    Herreid, Clyde Freeman; Schiller, Nancy A.

    2013-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue discusses the positive and negative aspects of the "flipped classroom." In the flipped classroom model, what is normally done in class and what is normally done as…

  3. Flipped Classroom Research and Trends from Different Fields of Study

    Science.gov (United States)

    Zainuddin, Zamzami; Halili, Siti Hajar

    2016-01-01

    This paper aims to analyse the trends and contents of flipped classroom research based on 20 articles that report on flipped learning classroom initiatives from 2013-2015. The content analysis was used as a methodology to investigate methodologies, area of studies, technology tools or online platforms, the most frequently used keywords and works…

  4. Flipped Classrooms and Student Learning: Not Just Surface Gains

    Science.gov (United States)

    McLean, Sarah; Attardi, Stefanie M.; Faden, Lisa; Goldszmidt, Mark

    2016-01-01

    The flipped classroom is a relatively new approach to undergraduate teaching in science. This approach repurposes class time to focus on application and discussion; the acquisition of basic concepts and principles is done on the students' own time before class. While current flipped classroom research has focused on student preferences and…

  5. Malaysian Students' Perceptions of Flipped Classroom: A Case Study

    Science.gov (United States)

    Zainuddin, Zamzami; Attaran, Mohammad

    2016-01-01

    The purpose of this study was to evaluate a class in University of Malaya where flipped learning was applied, and to examine students' perceptions and feedback towards flipped classroom. Data were collected using both quantitative and qualitative methods, i.e. survey, focus group and individual interviews. The results indicated that most students…

  6. Case Study: Guidelines for Producing Videos to Accompany Flipped Cases

    Science.gov (United States)

    Prud'homme-Généreux, Annie; Schiller, Nancy A.; Wild, John H.; Herreid, Clyde Freeman

    2017-01-01

    Three years ago, the "National Center for Case Study Teaching in Science" (NCCSTS) was inspired to merge the case study and flipped classroom approaches. The resulting project aimed to create the materials required to teach a flipped course in introductory biology by assigning videos as homework and case studies in the classroom. Three…

  7. Flipping College Algebra: Effects on Student Engagement and Achievement

    Science.gov (United States)

    Ichinose, Cherie; Clinkenbeard, Jennifer

    2016-01-01

    This study compared student engagement and achievement levels between students enrolled in a traditional college algebra lecture course and students enrolled in a "flipped" course. Results showed that students in the flipped class had consistently higher levels of achievement throughout the course than did students in the traditional…

  8. Student Perceptions of the Flipped Classroom in College Algebra

    Science.gov (United States)

    Ogden, Lori

    2015-01-01

    The flipped classroom approach was implemented across three semesters of a College Algebra course. This paper is part of a larger design and development research study and focuses on student perceptions of the flipped classroom teaching approach. Qualitative methodology was used to describe how students perceived the instruction of their College…

  9. Model studies of lipid flip-flop in membranes

    DEFF Research Database (Denmark)

    Parisio, Giulia; Ferrarini, Alberta; Sperotto, Maria Maddalena

    2016-01-01

    for the molecular-level understanding of flip-flop. In this review we present a summary of the state of the art of computational studies of spontaneous flip-flop of phospholipids, sterols and fatty acids. Also, we highlight critical issues and strategies that have been developed to solve them, and what remains...

  10. Flipping the Calculus Classroom: A Cost-Effective Approach

    Science.gov (United States)

    Young, Andrea

    2015-01-01

    This article discusses a cost-effective approach to flipping the calculus classroom. In particular, the emphasis is on low-cost choices, both monetarily and with regards to faculty time, that make the daunting task of flipping a course manageable for a single instructor. Student feedback and overall impressions are also presented.

  11. Flipping a College Calculus Course: A Case Study

    Science.gov (United States)

    Sahin, Alpaslan; Cavlazoglu, Baki; Zeytuncu, Yunus E.

    2015-01-01

    As online videos have become more easily available and more attractive to the new generation of students, and as new student-learning approaches tend to have more technology integration, the flipped classroom model has become very popular. The purpose of this study was to understand college students' views on flipped courses and investigate how…

  12. Flipping the Calculus Classroom: A Cost-Effective Approach

    Science.gov (United States)

    Young, Andrea

    2015-01-01

    This article discusses a cost-effective approach to flipping the calculus classroom. In particular, the emphasis is on low-cost choices, both monetarily and with regards to faculty time, that make the daunting task of flipping a course manageable for a single instructor. Student feedback and overall impressions are also presented.

  13. On Flipping First-Semester Calculus: A Case Study

    Science.gov (United States)

    Petrillo, Joseph

    2016-01-01

    High failure rates in calculus have plagued students, teachers, and administrators for decades, while science, technology, engineering, and mathematics programmes continue to suffer from low enrollments and high attrition. In an effort to affect this reality, some educators are "flipping" (or inverting) their classrooms. By flipping, we…

  14. On Flipping First-Semester Calculus: A Case Study

    Science.gov (United States)

    Petrillo, Joseph

    2016-01-01

    High failure rates in calculus have plagued students, teachers, and administrators for decades, while science, technology, engineering, and mathematics programmes continue to suffer from low enrollments and high attrition. In an effort to affect this reality, some educators are "flipping" (or inverting) their classrooms. By flipping, we…

  15. A Flipped Spoon and Chin Prompt to Increase Mouth Clean

    Science.gov (United States)

    Dempsey, Jack; Piazza, Cathleen C.; Groff, Rebecca A.; Kozisek, Jennifer M.

    2011-01-01

    We treated the liquid refusal of a 15-month-old girl using 2 antecedent manipulations: flipped spoon and chin prompt. Use of the chin prompt in the absence of the flipped spoon failed to produce increases in mouth clean (a product measure of swallowing). By contrast, modest increases in mouth clean resulted from the implementation of the flipped…

  16. Flipping to Teach the Conceptual Foundations of Successful Workplace Writing

    Science.gov (United States)

    Campbell, Kim Sydow

    2016-01-01

    Flipping originated in science, technology, engineering, and mathematics fields, where didactic transmission of conceptual knowledge has been the standard pedagogy. Flipping has resulted in additional focus on procedural knowledge within class meetings. This article argues that business and professional writing pedagogy, which already focuses…

  17. Application of Flipped Classroom to Vocational College English Teaching

    Institute of Scientific and Technical Information of China (English)

    宋薇

    2014-01-01

    Unlike traditional teaching method,flipped classroom is a form of blended learning in which students learn content online by watching video lecture,usually at home,and students and teachers discuss and solve questions by more personalized guidance and interaction in class,instead of lecturing.Flipped classroom is very useful to vocational college English teaching.

  18. The Perceived Effects of Flipped Teaching on Knowledge Acquisition

    Science.gov (United States)

    Newman, Galen; Kim, Jun-Hyun; Lee, Ryun Jung; Brown, Brandy A.; Huston, Sharon

    2016-01-01

    Increased demands for technological integration in higher education have resulted in new forms of course instruction. Under a flipped approach, students learn course materials outside the classroom while active learning methods are employed inside. This study focuses on the perceived effects of flipped instruction on knowledge acquisition in…

  19. The Implementation of a Flipped Classroom in Foreign Language Teaching

    Science.gov (United States)

    Basal, Ahmet

    2015-01-01

    Alongside the rise of educational technology, many teachers have been taking gradual but innovative steps to redesign their teaching methods. For example, in flipped learning or a flipped classroom, students watch instructional videos outside the classroom and do assignments or engage in activities inside the classroom. Language teachers are one…

  20. Examining Student Perceptions of Flipping an Agricultural Teaching Methods Course

    Science.gov (United States)

    Conner, Nathan W.; Rubenstein, Eric D.; DiBenedetto, Cathy A.; Stripling, Christopher T.; Roberts, T. Grady; Stedman, Nicole L. P.

    2014-01-01

    To meet the needs of the 21st century student, college instructors have been challenged to transform their classrooms from passive to active, "minds-on" learning environments. This qualitative study examined an active learning approach known as a flipped classroom and sought to explore student perceptions of flipping a teaching methods…

  1. Assessment of Learning Gains in a Flipped Biochemistry Classroom

    Science.gov (United States)

    Ojennus, Deanna Dahlke

    2016-01-01

    The flipped classroom has become an increasingly popular pedagogical approach to teaching and learning. In this study, learning gains were assessed in a flipped biochemistry course and compared to gains in a traditional lecture. Although measured learning gains were not significantly different between the two courses, student perception of…

  2. Flipping College Algebra: Effects on Student Engagement and Achievement

    Science.gov (United States)

    Ichinose, Cherie; Clinkenbeard, Jennifer

    2016-01-01

    This study compared student engagement and achievement levels between students enrolled in a traditional college algebra lecture course and students enrolled in a "flipped" course. Results showed that students in the flipped class had consistently higher levels of achievement throughout the course than did students in the traditional…

  3. Curriculum Design of a Flipped Classroom to Enhance Haematology Learning

    Science.gov (United States)

    Porcaro, Pauline A.; Jackson, Denise E.; McLaughlin, Patricia M.; O'Malley, Cindy J.

    2016-01-01

    A common trend in higher education is the "flipped" classroom, which facilitates active learning during class. The flipped approach to teaching was instituted in a haematology "major" class and the students' attitudes and preferences for the teaching materials were surveyed. The curriculum design was explicit and involved four…

  4. Assessing the Flipped Classroom in Operations Management: A Pilot Study

    Science.gov (United States)

    Prashar, Anupama

    2015-01-01

    The author delved into the results of a flipped classroom pilot conducted for an operations management course module. It assessed students' perception of a flipped learning environment after making them experience it in real time. The classroom environment was construed using a case research approach and students' perceptions were studied using…

  5. The Flipped Class: Experience in a University Business Communication Course

    Science.gov (United States)

    Sherrow, Tammy; Lang, Brenda; Corbett, Rod

    2016-01-01

    Business, like many other programs in higher education, continues to rely largely on traditional classroom environments. In this article, another approach to teaching and learning, the flipped classroom, is explored. After a review of relevant literature, the authors present their experience with the flipped classroom approach to teaching and…

  6. Using Presentation Software to Flip an Undergraduate Analytical Chemistry Course

    Science.gov (United States)

    Fitzgerald, Neil; Li, Luisa

    2015-01-01

    An undergraduate analytical chemistry course has been adapted to a flipped course format. Course content was provided by video clips, text, graphics, audio, and simple animations organized as concept maps using the cloud-based presentation platform, Prezi. The advantages of using Prezi to present course content in a flipped course format are…

  7. Exploring Flipped Classroom Effects on Second Language Learners' Cognitive Processing

    Science.gov (United States)

    Kim, Jeong-eun; Park, Hyunjin; Jang, Mijung; Nam, Hosung

    2017-01-01

    This study investigated the cognitive effects of the flipped classroom approach in a content-based instructional context by comparing second language learners' discourse in flipped vs. traditional classrooms in terms of (1) participation rate, (2) content of comments, (3) reasoning skills, and (4) interactional patterns. Learners in two intact…

  8. Partially Flipped Linear Algebra: A Team-Based Approach

    Science.gov (United States)

    Carney, Debra; Ormes, Nicholas; Swanson, Rebecca

    2015-01-01

    In this article we describe a partially flipped Introductory Linear Algebra course developed by three faculty members at two different universities. We give motivation for our partially flipped design and describe our implementation in detail. Two main features of our course design are team-developed preview videos and related in-class activities.…

  9. Application of Flipped Classroom to Vocational College English Teaching

    Institute of Scientific and Technical Information of China (English)

    宋薇

    2014-01-01

    Unlike traditional teaching method,flipped classroom is a form of blended learning in which students learn content online by watching video lecture,usually at home,and students and teachers discuss and solve questions by more personalized guidance and interaction in class,instead of lecturing. Flipped classroom is very useful to vocational college English teaching.

  10. The Flipped Class: Experience in a University Business Communication Course

    Science.gov (United States)

    Sherrow, Tammy; Lang, Brenda; Corbett, Rod

    2016-01-01

    Business, like many other programs in higher education, continues to rely largely on traditional classroom environments. In this article, another approach to teaching and learning, the flipped classroom, is explored. After a review of relevant literature, the authors present their experience with the flipped classroom approach to teaching and…

  11. Flipping photons backward: reversed Cherenkov radiation

    Directory of Open Access Journals (Sweden)

    Hongsheng Chen

    2011-01-01

    Full Text Available Charged particles moving faster than light in a medium produce Cherenkov radiation. In traditional, positive index-of-refraction materials this radiation travels forward. Metamaterials, with negative indices of refraction, flip the radiation backward. This readily separates it from the particles, providing higher flexibility in photon manipulation and is useful for particle identification and counting. Here we review recent advances in reversed Cherenkov radiation research, including the first demonstration of backward emission. We also discuss the potential for developing new types of devices, such as ones that pierce invisibility cloaks.

  12. uFlip: Understanding Flash IO Patterns

    DEFF Research Database (Denmark)

    Bouganim, Luc; Jonsson, Bjørn; Bonnet, Philippe

    2009-01-01

    want to establish what kind of IOs should be favored (or avoided) when designing algorithms and architectures for flash-based systems. In this paper, we focus on flash IO patterns, that capture relevant distribution of IOs in time and space, and our goal is to quantify their performance. We define u......FLIP, a benchmark for measuring the response time of flash IO patterns. We also present a benchmarking methodology which takes into account the particular characteristics of flash devices. Finally, we present the results obtained by measuring eleven flash devices, and derive a set of design hints that should drive...

  13. Pass transistor Based Negative Edge Trigged D Flip Flop (PTDFF

    Directory of Open Access Journals (Sweden)

    S. P. Nagamani Bai

    2014-04-01

    Full Text Available In this paper a new technique is proposed based on the comparison between Conventional Transistorized Flipflopand Data transition Look ahead D flip flop here we are checking the working of DLDFF and the conventional D Flip-flop after that we are analyzing the characteristic comparison using power & area constraints after that we are proposing a Negative Edge triggered flip-flop named as Passtransistor based negative edge trigged D Flip Flop(PTDFF with reduced number of transistors which will reduce the overall power area as well as delay. The simulations are done using Microwind& DSCH analysis software tools and the result between all those types are listed below. Our proposed system simulations are done under 50nm technology and the results are tabulated below. In that our proposed system is showing better output than the other flip-flops compared here.

  14. A Quasi Experiment to Determine the Effectiveness of a "Partially Flipped" versus "Fully Flipped" Undergraduate Class in Genetics and Evolution

    Science.gov (United States)

    Adams, Alison E. M.; Garcia, Jocelyn; Traustadóttir, Tinna

    2016-01-01

    Two sections of Genetics and Evolution were taught by one instructor. One group (the fully flipped section) had the entire class period devoted to active learning (with background material that had to be watched before class), and the other group (the partially flipped section) had just a portion of class time spent on active learning (with the…

  15. Application of Flipped Classroom in English Majors' Grammar Teaching%Application of Flipped Classroom in English Majors'Grammar Teaching

    Institute of Scientific and Technical Information of China (English)

    滕丽梅

    2016-01-01

    This paper analyzed how flipped classroom facilitated grammar teaching for English majors by indicating the principle status of students in class, shaping good classroom atmosphere of grammar learning and expanding English grammar teaching. Meanwhile, it raised strategies of flipped classroom applied in English majors' grammar teaching such as preparations before class and abundant teaching methods.

  16. Comparison of thermomigration behaviors between Pb-free flip chip solder joints and microbumps in three dimensional integrated circuits: Bump height effect

    Science.gov (United States)

    Ouyang, Fan-Yi; Jhu, Wei-Cheng

    2013-01-01

    Packaging technology is currently transition from flip chip technology to three dimensional integrated circuits (3D ICs) to meet the requirements of consumer electronic products. Compared to flip chip technology, the dimension of microbumps in 3D ICs is shrunk by a factor of 10. In this study, the behaviors of thermomigration in Pb-free solders of flip chip and 3D ICs are presented. When the bump height is 100 μm in the flip chip samples, the Sn protrusion was observed at the hot end and voids formation at the cold end. However, when the bump height is reduced to 5.8 μm in the 3D IC samples, no significant microstructural evolution of Sn was found; instead, the dissolution of Ni under-bump metallization at hot end was observed. We propose that discrepancy between flip chip solder joints and 3D IC microbumps is mainly attributed to the effect of back stress and the presence of thicker Ni under-bump metallization in the 3D IC packaging. Moreover, the critical temperature gradient in terms of different bump heights is discussed, showing below which there will be no net effect of thermomigration of Sn.

  17. Observations of Langmuir Circulation From FLIP

    Science.gov (United States)

    Smith, J. A.

    2002-12-01

    Langmuir circulation has significance across the marine disciplines. Enhanced deepening and inhibited re-stratification can alter the surface temperature and hence net air-sea exchanges. Organization of bubbles into windrows introduces dramatic sound speed variability and also affects air/sea gas fluxes. Organization of seaweed and plankton affects marine life, including pelagic fisheries. Finally, dispersal by Langmuir circulation is a major component in models for oil-spill tracking and for search-and-rescue operations. To get an adequate picture of the forcing and response of Langmuir circulation (and the wind-mixed layer in general), the observations needed include windstress, directional waves, wave breaking, heat and moisture fluxes, stratification (temperature and salinity profiles), velocity profiles across the mixed layer and thermocline, spacing and orientation of windrows, and a measure of the strength of the circulation (e.g., surface rms velocities). These measurements span both the air/sea interface and the thermocline, and must be maintained continuously for many days to span storms and daily, tidal, and inertial cycles. In addition, the total power requirements exceed that comfortably supplied by batteries or local generation by wind or solar energy. It appears that FLIP is uniquely qualified as a platform from which the required range of measurements may all be made. Findings concerning the evolution and dynamics of Langmuir circulation that were facilitated by FLIP are reviewed and summarized, with emphasis on observations from 1990, 1995, and 2002.

  18. 重力梯度法中台阶倾角的确定与实际应用%Step Angle of Gravity Gradient Method Determining and the Practical Application

    Institute of Scientific and Technical Information of China (English)

    孙鹏飞; 吴燕冈

    2011-01-01

    在计算重力梯度时使用波数域,引入别列兹金滤波因子来压制求导过程的误差放大,理论模型试验表明其空间参量图更接近实际;通过对谐波数N和滤波因子指数n的选择,压制复杂地形中干扰源的影响,并阐述了N和n的关系;通过对Vzz和Vxz沿测线方向的水平求导来精确确定台阶转折点位置,并根据重力异常曲线和地质资料剔除无意义的波峰和波谷,减少计算工作量.%This article used wave number space in the calculation of the gravity gradient, the introduction of B. M derivative filter factor to suppress the error amplification process. Model experiments show that the spatial parameters is closer to the actual figure; Filtering the harmonic number N and the choice of filter factor index n to suppress interference sources in the complex terrain, and describe the relationship between N and re; Gravity gradient method is usually the peak and trough for V zz choice with the subjectivity of human experience, Author think by Vzz and Vzz of the lateral line along the horizontal direction of the derivative position to accurately determine the level turning point,using gravity anomalies curves and geological data to eliminate meaningless peaks and troughs,to reduce the computational workload.

  19. Perceptions of Senior-Year ELT Students for Flipped Classroom: A Materials Development Course

    Science.gov (United States)

    Adnan, Müge

    2017-01-01

    This paper describes a structured attempt to integrate the flipped classroom model into a senior-level course at the higher education level. This study's purpose is to examine and compare the impact of flipped classrooms versus non-flipped as a means to contribute to the growing line of research on flipped teaching through an evaluation of both…

  20. Studenters erfaringer med Flipped Classroom i en helsefagutdanning

    Directory of Open Access Journals (Sweden)

    Christine Tørris

    2015-12-01

    Full Text Available Background: The flipped classroom approach has gained increased attention in educational research literature. The purpose of this study was to investigate how students experience a flipped classroom approach in health education, compared to ordinary lectures. Method: Bachelor students (n=25 who watched the video-based material in the flipped classrooms pre-session, answered a questionnaire to evaluate their flipped classroom experience. The questionnaire consisted of both closed and open questions. Results: Ninety six per cent (24/25 of respondents found the video-based material in the pre-session useful. Seventy six per cent (19/25 of respondents found that the flipped classroom approach resulted in the highest learning outcome, over the traditional approach (16%, 4/25. Barriers to the flipped classroom approach was technical problems with the video-based material, such as screen view. Conclusion: The flipped classroom approach is promising as an acceptable approach for teaching in health science curricular in higher education.

  1. Magnetic flipping - Reconnection in three dimensions without null points

    Science.gov (United States)

    Priest, E. R.; Forbes, T. G.

    1992-01-01

    In three dimensions, magnetic reconnection may take place in a sheared magnetic field at any singular field line, where the nearby field has X-type topology in planes perpendicular to the field line and where an electric field is present parallel to the field line. In the ideal region around the singular line there will, in general, be singularities in the plasma flow and electric field, both at the singular line and at 'magnetic flipping layers', which are remnants of local magnetic separatrices. In the absence of a three-dimensional magnetic neutral point or null point, reconnection of field lines can still occur by a process of magnetic flipping, in which the plasma crosses the flipping layers but the field lines rapidly flip along them by magnetic diffusion. Depending on the boundary conditions, there may be two or four flipping layers which converge on the singular line. A boundary layer analysis of a flipping layer is given, in which the magnetic field parallel to the layer decreases as one crosses it while the plasma pressure (or magnetic pressure associated with the field along the singular line) increases. The width of the flipping layer decreases with distance from the singular line.

  2. Magnetic flipping: Reconnection in three-dimensions without null points

    Energy Technology Data Exchange (ETDEWEB)

    Priest, E.R.; Forbes, T.G. (Univ. of New Hampshire, Durham (United States))

    1992-02-01

    In three dimensions, magnetic reconnection may take place in a sheared magnetic field at any singular field line, where the nearby field has X-type topology in planes perpendicular to the field line and where an electric field is present parallel to the field line. In the ideal region around the singular line there will, in general, be singularities in the plasma flow and electric field, both at the singular line and at magnetic flipping layers, which are remnants of local magnetic separatrices. In the absence of a three-dimensional magnetic point or null point, reconnection of field lines can still occur by a process of magnetic flipping, in which the plasma crosses the flipping layers but the field lines rapidly flip along them by magnetic diffusion. Depending on the boundary conditions, there may be two or four flipping layers which converge on the singular line. A boundary layer analysis of a flipping layer is given, in which the magnetic field parallel to the layer decreases as one crosses it while the plasma pressure (or magnetic pressure associated with the field along the singular line) increases. The width of the flipping layer decreases with distance from the singular line.

  3. Studenters erfaringer med Flipped Classroom i en helsefagutdanning

    Directory of Open Access Journals (Sweden)

    Christine Tørris

    2015-12-01

    Full Text Available Background: The flipped classroom approach has gained increased attention in educational research literature. The purpose of this study was to investigate how students experience a flipped classroom approach in health education, compared to ordinary lectures. Method: Bachelor students (n=25 who watched the video-based material in the flipped classrooms pre-session, answered a questionnaire to evaluate their flipped classroom experience. The questionnaire consisted of both closed and open questions. Results: Ninety six per cent (24/25 of respondents found the video-based material in the pre-session useful. Seventy six per cent (19/25 of respondents found that the flipped classroom approach resulted in the highest learning outcome, over the traditional approach (16%, 4/25. Barriers to the flipped classroom approach was technical problems with the video-based material, such as screen view. Conclusion: The flipped classroom approach is promising as an acceptable approach for teaching in health science curricular in higher education.

  4. Secular precessing compact binary dynamics, spin and orbital angular momentum flip-flops

    CERN Document Server

    Tápai, Márton; Gergely, László Árpád

    2016-01-01

    We derive the conservative secular evolution of precessing compact binaries to second post-Newtonian order accuracy, with leading-order spin-orbit, spin-spin and mass quadrupole-monopole contributions included. The emerging closed system of first-order differential equations evolves the pairs of polar and azimuthal angles of the spin and orbital angular momentum vectors together with the periastron angle. In contrast with the instantaneous dynamics, the secular dynamics is autonomous. This secular dynamics reliably characterizes the system over timescales starting from a few times the radial period to several precessional periods, but less than the radiation reaction timescale. We numerically compare the instantaneous and secular evolutions and estimate the number of periods for which dissipation has no significant effect, e.g. the conservative timescale. We apply the analytic equations to study the spin flip-flop effect, recently found by numerical relativity methods. Our investigations show that the effect ...

  5. The Phenomenology of Flipped SU(5)

    Science.gov (United States)

    Abel, S. A.

    1990-01-01

    Available from UMI in association with The British Library. In this thesis, I examine the phenomenology of the supersymmetric flipped SU(5) model. Such a model has been derived as a low energy approximation to heterotic string theory, probably with a 'no-scale' supersymmetry breaking mechanism. It is found that a large region of the flipped SU(5) parameter space predicts a satisfactory breaking down to the standard model on renormalization down to low energies. In particular it contains a number of phenomenological advantages over other GUT schemes, such as a natural Higg's doublet-triplet mass splitting, and a neutrino see-saw mechanism. Analysis of the neutrino sector shows that this model may allow rapid decays of the heavy neutrinos into lighter electron-neutrinos. This is due to new flavour changing couplings in the superpotential, which are included in the neutrino mass matrix. Such fast decays may be able to evade certain cosmological bounds, based on the standard inflationary scenarios and the observation of the 3K background radiation. Thus it is possible that neutrinos could form a substantial proportion of the dark matter in the Universe. Rare processes may be significantly enhanced in the flipped SU(5) scenario, due to new couplings whose off diagonal Kobayashi-Maskawa matrix elements need not be small. In particular, the gaugino-fermion-sfermion coupling may give important new flavour changing diagrams, since, after supersymmetry is broken, the fermions and sfermions are no longer simultaneously diagonalizable. This leads to the possibility of decays such as Z to bs and muto egamma being detected in the near future. In addition to this there are significant new contributions to the electric dipole moment of the neutron which may be as high as the present day limit of | d_ n| < 10^{-25}ecm. Support for this model may come from neutralino contributions to the number of 'neutrino species' measured in Z decays. Finally, the anomalous magnetic moment of the

  6. Research, Perspectives, and Recommendations on Implementing the Flipped Classroom.

    Science.gov (United States)

    Rotellar, Cristina; Cain, Jeff

    2016-03-25

    Flipped or inverted classrooms have become increasingly popular, and sometimes controversial, within higher education. Many educators have touted the potential benefits of this model and initial research regarding implementation has been primarily positive. The rationale behind the flipped classroom methodology is to increase student engagement with content, increase and improve faculty contact time with students, and enhance learning. This paper presents a summary of primary literature regarding flipped classrooms, discusses concerns and unanswered questions from both a student and faculty member perspective, and offers recommendations regarding implementation.

  7. Integral Optimization of Systematic Parameters of Flip-Flow Screens

    Institute of Scientific and Technical Information of China (English)

    翟宏新

    2004-01-01

    The synthetic index Ks for evaluating flip-flow screens is proposed and systematically optimized in view of the whole system. A series of optimized values of relevant parameters are found and then compared with those of the current industrial specifications. The results show that the optimized value Ks approaches the one of those famous flip-flow screens in the world. Some new findings on geometric and kinematics parameters are useful for improving the flip-flow screens with a low Ks value, which is helpful in developing clean coal technology.

  8. Polarizing a stored proton beam by spin flip?

    CERN Document Server

    Oellers, D; Barsov, S; Bechstedt, U; Benati, P; Bertelli, S; Chiladze, D; Ciullo, G; Contalbrigo, M; Dalpiaz, P F; Dietrich, J; Dolfus, N; Dymov, S; Engels, R; Erven, W; Garishvili, A; Gebel, R; Goslawski, P; Grigoryev, K; Hadamek, H; Kacharava, A; Khoukaz, A; Kulikov, A; Langenberg, G; Lehrach, A; Lenisa, P; Lomidze, N; Lorentz, B; Macharashvili, G; Maier, R; Martin, S; Merzliakov, S; Meshkov, I N; Meyer, H O; Mielke, M; Mikirtychiants, M; Mikirtychiants, S; Nass, A; Nekipelov, M; Nikolaev, N N; Nioradze, M; d'Orsaneo, G; Papenbrock, M; Prasuhn, D; Rathmann, F; Sarkadi, J; Schleichert, R; Smirnov, A; Seyfarth, H; Sowinski, J; Spoelgen, D; Stancari, G; Stancari, M; Statera, M; Steffens, E; Stein, H J; Stockhorst, H; Straatmann, H; Ströher, H; Tabidze, M; Tagliente, G; Engblom, P Thoerngren; Trusov, S; Vasilyev, A; Weidemann, Chr; Welsch, D; Wieder, P; Wüstner, P; Zupranski, P

    2009-01-01

    We discuss polarizing a proton beam in a storage ring, either by selective removal or by spin flip of the stored ions. Prompted by recent, conflicting calculations, we have carried out a measurement of the spin flip cross section in low-energy electron-proton scattering. The experiment uses the cooling electron beam at COSY as an electron target. The measured cross sections are too small for making spin flip a viable tool in polarizing a stored beam. This invalidates a recent proposal to use co-moving polarized positrons to polarize a stored antiproton beam.

  9. Introducing a Flipped Classroom for a Statistics Course

    DEFF Research Database (Denmark)

    Triantafyllou, Eva; Timcenko, Olga

    2014-01-01

    One of the novel ideas in teaching that heavily relies on current technology is the “flipped classroom” approach, or “inverse teaching”. In a flipped classroom the traditional lecture and homework sessions are inverted. Students are provided with online material in order to gain necessary knowledge...... students in a Bachelor program in Media Technology. The results of the experiment revealed some strengths and weaknesses of this instructional model. We conclude that the flipped classroom can be beneficial for students, provided that it is based on a careful design....

  10. Assisted crack tip flipping under Mode I thin sheet tearing

    DEFF Research Database (Denmark)

    Felter, Christian Lotz; Nielsen, Kim Lau

    2017-01-01

    such as slanting, cup-cone (rooftop), or cup-cup (bathtub) the flipping crack never settles in a steady-state as the near tip stress/strain field continuously change when the flip successively initiates and develops shear-lips. A recent experimental investigation has revealed new insight by exploiting 3D X...... type loading) on the tip of a slant Mode I crack can provoke it to flip to the opposite side. Both experiments and micro-mechanics based modeling support this hypothesis....

  11. Operation and Maintenance of the Research Platform FLIP

    Science.gov (United States)

    2015-07-01

    operate safety in sup^urt uf uNk fcSedieh. \\ uiiJin^ ficts also cuveieJ the cust uf a ruutlnc dry docking of FLIP in 2013. Dry dockings occur at 3...support of ONR research. ONR funding has also covered the cost of an 18 June to 18 July 2013 routine dry docking , of FLIP. Dry dockings occur at a 3-year...18 July 2013, FLIP underwent a routine dry dockings in the navy floating dry dock USS ARCO ARDM 5 at the Naval Base Point Loma, San Diego. Routine

  12. [Flipped classroom in basic medical education].

    Science.gov (United States)

    Merenmies, Jussi; Niemi-Murola, Leila; Pyörälä, Eeva

    2015-01-01

    Medical education is facing changes in order to improve young doctors' competency to respond better to current needs of the patients and the society. Both curriculum content and teaching methods are revised. In addition to vibrant research in academic medical education, teachers are supported by the improved web-based learning environments and novel technical tools. Flipped classroom, a new paradigm that benefits from technical development, provides many opportunities for medical education. This teaching method always consists of two mutually complementary parts. The first part of the learning action takes place independently off classroom with video lectures or other stimuli for learning. The second part takes place in conjunction with the teacher and other students, and requires student group interactions.

  13. Front propagation and rejuvenation in flipping processes

    Energy Technology Data Exchange (ETDEWEB)

    Ben-naim, Eli [Los Alamos National Laboratory; Krapivsky, P I [BOSTON UNIV; Antal, T [HARVARD UNIV; Ben - Avrahm, D [HARVARD UNIV

    2008-01-01

    We study a directed flipping process that underlies the performance of the random edge simplex algorithm. In this stochastic process, which takes place on a one-dimensional lattice whose sites may be either occupied or vacant, occupied sites become vacant at a constant rate and simultaneously cause all sites to the right to change their state. This random process exhibits rich phenomenology. First, there is a front, defined by the position of the leftmost occupied site, that propagates at a nontrivial velocity. Second, the front involves a depletion zone with an excess of vacant sites. The total excess {Delta}{sub k} increases logarithmically, {Delta}{sub k} {approx_equal}ln k, with the distance k from the front. Third, the front exhibits ageing -- young fronts are vigorous but old fronts are sluggish. We investigate these phenomena using a quasi-static approximation, direct solutions of small systems and numerical simulations.

  14. Bridging the gap with flipped classroom

    DEFF Research Database (Denmark)

    Selberg, Hanne; Topperzer, Martha

    2016-01-01

    using educational technologies such as online preparation contents and simulation based scenarios. Furthermore, the objective is to enhance theory-practice integration in the educational setting. Materials & Methods The flipped classroom model replaces three theoretical lectures addressing disease...... are designed according to Dieckmann´s model (2009) consisting of a pre-briefing with the possibility to reflect on and clarify uncertainties relating to theory and physiology relating to the simulation themes, which are then followed by setting intro, simulator briefing, scenarios and debriefing...... • Challenges the students´ performance • Facilitates an enhanced level of reflection and engagement in debriefing • The concept allows theoretical knowledge to be translated into practical application • The theory-practice integration enhances the learning outcome and helps memorize the content • Applying...

  15. Selection of the new position for the instrumented fuel Flip type; Seleccion de la nueva posicion para el combustible instrumentado tipo Flip

    Energy Technology Data Exchange (ETDEWEB)

    Paredes G, L.C

    1991-12-15

    It was selected and proved the new position for the instrumented fuel, in function of the smallest influence on the temperature of the fuel due to movements of the control bars, as well as to its functionality regarding their geometric localization in the core. Therefore, it intends that the instrumented fuel Flip type, pass from the position C-9 to the C-6. It was selected the turn angle of the fuel of 180 C, for to be the one that presents a smaller influence of the control bars and it allows to register the values of temperature but high. It was as the movements of the control bars they produce local interferences of the neutron flow in the fuels and that in the case of the ring C, these interferences became maximum variations of the fuel temperature of 125 C, for operations to 1 MW in the thermal column. (Author)

  16. Flipping the classroom to improve student performance and satisfaction.

    Science.gov (United States)

    Missildine, Kathy; Fountain, Rebecca; Summers, Lynn; Gosselin, Kevin

    2013-10-01

    This study aimed to determine the effects of a flipped classroom (i.e., reversal of time allotment for lecture and homework) and innovative learning activities on academic success and the satisfaction of nursing students. A quasi-experimental design was used to compare three approaches to learning: traditional lecture only (LO), lecture and lecture capture back-up (LLC), and the flipped classroom approach of lecture capture with innovative classroom activities (LCI). Examination scores were higher for the flipped classroom LCI group (M = 81.89, SD = 5.02) than for both the LLC group (M = 80.70, SD = 4.25), p = 0.003, and the LO group (M = 79.79, SD = 4.51), p flipped classroom method than with either of the other methods (p classroom activities can result in improved learning but not necessarily improved student satisfaction.

  17. Evaluation of a Flipped Drug Literature Evaluation Course.

    Science.gov (United States)

    Giuliano, Christopher Alan; Moser, Lynette R

    2016-05-25

    Objective. To evaluate a flipped drug literature evaluation course for first-year pharmacy students. Design. A drug literature evaluation course was flipped during the 2014 winter semester. Homework from 2013 was transformed into activities and lectures were transformed into multiple short YouTube videos. Assessment. Average examination scores increased from 75.6% to 86.1%. Eighty-two of 94 students completed the postcourse survey in 2014. Compared to traditional lecture, 59.8% of students indicated they preferred the flipped course. Additionally, students felt the course was important, the in-class activities were helpful, and some of the YouTube videos could be improved. We found length of the video to be significantly correlated with the percentage of videos viewed. Conclusion. The flipped model should be considered in drug literature evaluation courses that seek to increase the amount of active learning in the classroom.

  18. What millennial medical students say about flipped learning.

    Science.gov (United States)

    Pettit, Robin K; McCoy, Lise; Kinney, Marjorie

    2017-01-01

    Flipped instruction is gaining popularity in medical schools, but there are unanswered questions such as the optimum amount of the curriculum to flip and whether flipped sessions should be mandatory. We were in a unique position to evaluate feedback from first-year medical students who had experienced both flipped and lecture-based courses during their first semester of medical school. A key finding was that the students preferred a variety of different learning formats over an "all or nothing" learning format. Learning format preferences did not necessarily align with perceptions of which format led to better course exam performance. Nearly 70% of respondents wanted to make their own decisions regarding attendance. Candid responses to open-ended survey prompts reflected millennial preferences for choice, flexibility, efficiency, and the ability to control the pace of their learning, providing insight to guide curricular improvements.

  19. Online Learning Room for ”Flipped Classroom”

    DEFF Research Database (Denmark)

    Bugge, Ellen Margrethe; Nielsen, Linda Susanna Hauschildt

    2014-01-01

    working actively and innovatively to create a didactic design in our online learning rooms in our LMS that satisfy the demands for flipped learning and at the same time adapted to the special needs of each learning module at the nursing education programme. Keywords: Online learning, flipped classroom......Abstract The “flipped classroom” learning concept is an alternative way of teaching & learning. The fundamental idea of the "flipped classroom" is to change the way students prepare for classes and the work that takes place when the students are together in the classroom. This integrates online...... learning with learning in the classroom. The learning room must support the students’ unassisted learning, their preparation for class and their preparation for supervision in both a motivating and clear way. At the Nursing Education Programme at University College Lillebaelt in Denmark, we have been...

  20. Flipped classroom model for learning evidence-based medicine.

    Science.gov (United States)

    Rucker, Sydney Y; Ozdogan, Zulfukar; Al Achkar, Morhaf

    2017-01-01

    Journal club (JC), as a pedagogical strategy, has long been used in graduate medical education (GME). As evidence-based medicine (EBM) becomes a mainstay in GME, traditional models of JC present a number of insufficiencies and call for novel models of instruction. A flipped classroom model appears to be an ideal strategy to meet the demands to connect evidence to practice while creating engaged, culturally competent, and technologically literate physicians. In this article, we describe a novel model of flipped classroom in JC. We present the flow of learning activities during the online and face-to-face instruction, and then we highlight specific considerations for implementing a flipped classroom model. We show that implementing a flipped classroom model to teach EBM in a residency program not only is possible but also may constitute improved learning opportunity for residents. Follow-up work is needed to evaluate the effectiveness of this model on both learning and clinical practice.

  1. What millennial medical students say about flipped learning

    Science.gov (United States)

    Pettit, Robin K; McCoy, Lise; Kinney, Marjorie

    2017-01-01

    Flipped instruction is gaining popularity in medical schools, but there are unanswered questions such as the optimum amount of the curriculum to flip and whether flipped sessions should be mandatory. We were in a unique position to evaluate feedback from first-year medical students who had experienced both flipped and lecture-based courses during their first semester of medical school. A key finding was that the students preferred a variety of different learning formats over an “all or nothing” learning format. Learning format preferences did not necessarily align with perceptions of which format led to better course exam performance. Nearly 70% of respondents wanted to make their own decisions regarding attendance. Candid responses to open-ended survey prompts reflected millennial preferences for choice, flexibility, efficiency, and the ability to control the pace of their learning, providing insight to guide curricular improvements. PMID:28769600

  2. Polymer Flip Chips with Extreme Temperature Stability in Space Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The objective of the proposed SBIR Phase I program is to develop highly thermally and electrically conductive nanocomposites for space-based flip chips for...

  3. Flipped classroom model for learning evidence-based medicine

    Science.gov (United States)

    Rucker, Sydney Y; Ozdogan, Zulfukar; Al Achkar, Morhaf

    2017-01-01

    Journal club (JC), as a pedagogical strategy, has long been used in graduate medical education (GME). As evidence-based medicine (EBM) becomes a mainstay in GME, traditional models of JC present a number of insufficiencies and call for novel models of instruction. A flipped classroom model appears to be an ideal strategy to meet the demands to connect evidence to practice while creating engaged, culturally competent, and technologically literate physicians. In this article, we describe a novel model of flipped classroom in JC. We present the flow of learning activities during the online and face-to-face instruction, and then we highlight specific considerations for implementing a flipped classroom model. We show that implementing a flipped classroom model to teach EBM in a residency program not only is possible but also may constitute improved learning opportunity for residents. Follow-up work is needed to evaluate the effectiveness of this model on both learning and clinical practice. PMID:28919831

  4. Step to improve neural cryptography against flipping attacks.

    Science.gov (United States)

    Zhou, Jiantao; Xu, Qinzhen; Pei, Wenjiang; He, Zhenya; Szu, Harold

    2004-12-01

    Synchronization of neural networks by mutual learning has been demonstrated to be possible for constructing key exchange protocol over public channel. However, the neural cryptography schemes presented so far are not the securest under regular flipping attack (RFA) and are completely insecure under majority flipping attack (MFA). We propose a scheme by splitting the mutual information and the training process to improve the security of neural cryptosystem against flipping attacks. Both analytical and simulation results show that the success probability of RFA on the proposed scheme can be decreased to the level of brute force attack (BFA) and the success probability of MFA still decays exponentially with the weights' level L. The synchronization time of the parties also remains polynomial with L. Moreover, we analyze the security under an advanced flipping attack.

  5. PENGARUH FLIPPED MASTERY CLASSROM TERHADAP PEROLEHAN HASIL BELAJAR KOGNITIF MAHASISWA

    Directory of Open Access Journals (Sweden)

    Muhammad Ridha

    2016-04-01

    Tujuan dari penelitian ini adalah untuk mengetahui pengaruh penerapan strategi flipped mastery classroom terhadap perolehan hasil belajar kognitif mahasiswa pada matakuliah psikologi pendidikan. Subjek dalam penelitian ini adalah mahasiswa Jurusan Teknologi Pendidikan Universitas Negeri Malang semester genap tahun ajaran 2015/2016 pada kelas utuh. Kelas eksperimen dibelajarkan dengan strategi flipped-mastery classroom dan kelas kontrol dibelajarkan dengan strategi tradisional.  Penelitian ini menggunakan rancangan kuasi eksperimen Non Equivalent Control Group Design. Hasil penelitian menunjukkan bahwa penerapan strategi flipped mastery classroom memberikan pengaruh positif terhadap perolehan hasil belajar kognitif mahasiswa. Perolehan hasil belajar kognitif mahasiswa yang dibelajarkan dengan strategi flipped-mastery lebih tinggi secara signifikan dari pada perolehan hasil belajar mahasiswa yang dibelajarkan dengan strategi tradisional.

  6. Implementing the Flipped Classroom in Teacher Education: Evidence from Turkey

    National Research Council Canada - National Science Library

    Gökçe Kurt

    2017-01-01

    The flipped classroom, a form of blended learning, is an emerging instructional strategy reversing a traditional lecture-based teaching model to improve the quality and efficiency of the teaching and learning process...

  7. Using the flipped classroom in graduate nursing education.

    Science.gov (United States)

    Critz, Catharine M; Knight, Diane

    2013-01-01

    A flipped classroom is a pedagogical model that involves having students view online lectures, read current evidence-based articles, and complete text readings prior to class. Students then come to class ready to actively engage in collaborative learning through case scenarios, small group discussion, or other meaningful, interactive activities. The flipped classroom model described here was an overwhelming success for both students and faculty.

  8. The Implementation of A Flipped Classroom in Foreign Language Teaching

    Directory of Open Access Journals (Sweden)

    Ahmet BASAL

    2015-10-01

    Full Text Available Alongside the rise of educational technology, many teachers have been taking gradual but innovative steps to redesign their teaching methods. For example, in flipped learning or a flipped classroom, students watch instructional videos outside the classroom and do assignments or engage in activities inside the classroom. Language teachers are one group of educators exploring the flipped classroom. In foreign language classes, such an approach may offer great benefits for both the teachers and students since classroom time can be applied to more interactive tasks. By extending classroom hours in this way, language teachers can focus on successfully addressing all subjects in the curriculum. The aim of this study is (a to gain insights into the perceptions of prospective English language teachers at a state university in Turkey on flipped classrooms and (b to introduce the implementation of a flipped classroom into an English language class. A total of 47 prospective English teachers participated in the study. Qualitative research design was used and data were collected via an open-ended question. Findings of the study indicated that pre-service English teachers had positive perceptions towards the use of the flipped classroom as an integral part of face-to-face courses. It can be concluded that flipped classroom was beneficial in terms of 4 categories based on the content analysis of the responses: learning at one’s own pace, advance student preparation, overcoming the limitations of class time, increasing the participation in the classroom. The study also provides recommendations towards LMS integration into courses in other English language teaching departments and for implementing flipped classrooms in language teaching.

  9. Spin-flip noise in a multiterminal spin valve

    OpenAIRE

    Belzig, Wolfgang; Zareyan, Malek

    2004-01-01

    We study shot noise and cross-correlations in a four terminal spin-valve geometry using a Boltzmann-Langevin approach. The Fano factor (shot noise to current ratio) depends on the magnetic configuration of the leads and the spin-flip processes in the normal metal. In a four-terminal geometry, spin-flip processes are particularly prominent in the cross-correlations between terminals with opposite magnetization.

  10. Optimization of nuclear magnetic resonance refocusing pulses to enhance signal intensity in gradient B0 field∗%优化重聚脉冲提高梯度场核磁共振信号强度*

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    It is an efficient protocol to use the refocusing flip angle pulse optimization technique to solve special engineering technical problems in nuclear magnetic resonance (NMR) measurements. By reducing RF pulse duration, the low refocusing flip angle pulses can consume lower power, satisfy specific absorption rate of samples, and improve signal-to-noise ratio as well. To further analyze the function mechanism of pulse angles, the dependence of signal intensity on RF pulse is studied in homogenous magnetic field and constant gradient magnetic field respectively. Afterwards, echo amplitudes with various tip angles and flip angles ranging from 0◦ to 180◦ are compared with conventional sequence of 90◦ pulse followed by 180◦ pulses theoretically and experimentally. For the constant gradient field, the refocusing pulse of flip angle can be as low as 140◦, defined as the optimum herein, to obtain the strongest signal intensity, enhanced by 13%compared with that of 180◦. Moreover, T1 distributions measured by the conventional and optimal sequences for distilled water at room temperature are compared, and good conformances of T1 between the two pulse sequences are obtained, which demonstrates the optimal refocusing pulse can be directly applied to T1 measurement. The results provide constructive suggestion for designing pulse sequences for signal intensity enhancement in NMR logging while drilling and NMR online quick analysis.%  缩短射频脉冲宽度,有助于解决脉冲电力消耗大、样品吸收率高、信噪比低等极端条件核磁共振探测的关键问题。本文首先分析射频脉冲角度对核磁共振自旋回波信号强度的影响机理,基于Bloch方程推导了回波信号幅度与扳转角、重聚角的关系。在特制核磁共振分析仪上采用变脉冲角度技术,分别在均匀磁场和梯度磁场条件下实现对扳转角和重聚角与回波信号强度关系的数值模拟和实验测量。结果表明,

  11. Do hummingbirds use a different mechanism than insects to flip and twist their wings?

    Science.gov (United States)

    Song, Jialei; Luo, Haoxiang; Hedrick, Tyson

    2014-11-01

    Hovering hummingbirds flap their wings in an almost horizontal stroke plane and flip the wings to invert the angle of attack after stroke reversal, a strategy also utilized by many hovering insects such as fruit flies. However, unlike insects whose wing actuation mechanism is only located at the base, hummingbirds have a vertebrate musculoskeletal system and their wings contain bones and muscles and thus, they may be capable of both actively flipping and twisting their wings. To investigate this issue, we constructed a hummingbird wing model and study its pitching dynamics. The wing kinematics are reconstructed from high-speed imaging data, and the inertial torques are calculated in a rotating frame of reference using mass distribution data measured from dissections of hummingbird wings. Pressure data from a previous CFD study of the same wing kinematics are used to calculate the aerodynamic torque. The results show that like insect wings, the hummingbird wing pitching is driven by its own inertia during reversal, and the aerodynamic torque is responsible for wing twist during mid-stroke. In conclusion, our study suggests that their wing dynamics are very similar even though their actuation systems are entirely different. This research was supported by the NSF.

  12. The flipped classroom: now or never?

    Science.gov (United States)

    Hawks, Sharon J

    2014-08-01

    Pedagogical changes and new models of delivering educational content should be considered in the effort to address the recommendations of the 2007 Institute of Medicine report and Benner's recommendations on the radical transformation of nursing. Transition to the nurse anesthesia practice doctorate addresses the importance of these recommendations, but educational models and specific strategies on how to implement changes in educational models and systems are still emerging. The flipped classroom (FC) is generating a considerable amount of buzz in academic circles. The FC is a pedagogical model that employs asynchronous video lectures, reading assignments, practice problems, and other digital, technology-based resources outside the classroom, and interactive, group-based, problem-solving activities in the classroom. This FC represents a unique combination of constructivist ideology and behaviorist principles, which can be used to address the gap between didactic education and clinical practice performance. This article reviews recent evidence supporting use of the FC in health profession education and suggests ways to implement the FC in nurse anesthesia educational programs.

  13. Flipping organic chemistry course: Possibilities and challenges

    Science.gov (United States)

    Cha, J.; Kim, H. B.

    2016-06-01

    The flipped classroom approach was applied to an introductory organic chemistry course. A total of 76 video clips (15 hours of running time) were developed and delivered to 41 sophomores (21 females and 20 males) through Youtube in addition to the university's learning management system. The students were asked to preview the lecture contents before each class by watching a pre-class video. For in-class activities, exercise problems were presented to groups of 3-5 students. An instructor and a teaching assistant guided each group to solve problems cooperatively, monitored the students’ group activity and answered their questions. At the end of every chapter, the students were asked to evaluate their group work and personal preparedness for the class and also to write a short reflective journal. The muddiest point of each chapter, i.e., the topic posing the most difficulty to students’ understanding, was surveyed through Google Forms®. The students liked watching the videos before each class and performing student-centered, in-class group activities but a few limitations were also found and reported.

  14. Flipped classroom or an active lecture?

    Science.gov (United States)

    Pickering, James D; Roberts, David J H

    2017-08-31

    Recent changes in anatomy education have seen the introduction of flipped classrooms as a replacement to the traditional didactic lecture. This approach utilizes the increasing availability of digital technology to create learning resources that can be accessed prior to attending class, with face-to-face sessions then becoming more student-centered via discussion, collaborative learning, and problem-solving activities. Although this approach may appear intuitive, this viewpoint commentary presents a counter opinion and highlights a simple alternative that utilizes evidence-based active learning approaches as part of the traditional lecture. The active lecture takes the traditional lecture, and (1) ensures the lecture content is relevant and has clear objectives, (2) contains lecture material that is designed according to the latest evidence-base, (3) complements it with additional supplementary material, (4) creates space to check prior understanding and knowledge levels, and (5) utilizes suitable technology to facilitate continual engagement and interaction. Clin. Anat., 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  15. Droplet Motion on a Shape Gradient Surface.

    Science.gov (United States)

    Zheng, Yanfen; Cheng, Jiang; Zhou, Cailong; Xing, Haiting; Wen, Xiufang; Pi, Pihui; Xu, Shouping

    2017-05-02

    We demonstrate a facile method to induce water droplet motion on an wedge-shaped superhydrophobic copper surface combining with a poly(dimethylsiloxane) (PDMS) oil layer on it. The unbalanced interfacial tension from the shape gradient offers the actuating force. The superhydrophobicity critically eliminates the droplet contact line pinning and the slippery PDMS oil layer lubricates the droplet motion, which makes the droplet move easily. The maximum velocity and furthest position of droplet motion were recorded and found to be influenced by the gradient angle. The mechanism of droplet motion on the shape gradient surface is systematically discussed, and the theoretical model analysis is well matched with the experimental results.

  16. On flipping first-semester calculus: a case study

    Science.gov (United States)

    Petrillo, Joseph

    2016-05-01

    High failure rates in calculus have plagued students, teachers, and administrators for decades, while science, technology, engineering, and mathematics programmes continue to suffer from low enrollments and high attrition. In an effort to affect this reality, some educators are 'flipping' (or inverting) their classrooms. By flipping, we mean administering course content outside of the classroom and replacing the traditional in-class lectures with discussion, practice, group work, and other elements of active learning. This paper presents the major results from a three-year study of a flipped, first-semester calculus course at a small, comprehensive, American university with a well-known engineering programme. The data we have collected help quantify the positive and substantial effects of our flipped calculus course on failure rates, scores on the common final exam, student opinion of calculus, teacher impact on measurable outcomes, and success in second-semester calculus. While flipping may not be suitable for every teacher, every student, and in every situation, this report provides some evidence that it may be a viable option for those seeking an alternative to the traditional lecture model.

  17. Active Longitudes and Flip-Flops in Binary Stars

    Science.gov (United States)

    Korhonen, Heidi; Järvinen, Silva P.

    2007-08-01

    In many active stars the spots concentrate on two permanent active longitudes which are 180 degrees apart. In some of these stars the dominant part of the spot activity changes the longitude every few years. This so-called flip-flop phenomenon was first reported in the early 1990's in the single, late type giant FK Com. Since then flip-flops have been reported also on binary stars, young solar type stars and the Sun itself. Even though this phenomenon has been detected on many different kinds of active stars, still less than ten stars are known to exhibit this effect. Therefore no statistically significant correlation between the stellar parameters and the flip-flop phenomenon can be carried out. Here we present results from investigation where we have studied the long-term photometry of several magnetically active RS CVn binaries to see whether or not they show permanent active longitudes and the flip-flop phenomenon. We find that it is very common for the active regions to occur on permanent active longitudes, and some of these stars also show clear flip-flop phenomenon.

  18. [Flipped classroom as a strategy to enhance active learning].

    Science.gov (United States)

    Wakabayashi, Noriyuki

    2015-03-01

    This paper reviews the introduction of a flipped class for fourth grade dentistry students, and analyzes the characteristics of the learning method. In fiscal 2013 and 2014, a series of ten three-hour units for removable partial prosthodontics were completed with the flipped class method; a lecture video of approximately 60 minutes was made by the teacher (author) and uploaded to the university's e-learning website one week before each class. Students were instructed to prepare for the class by watching the streaming video on their PC, tablet, or smartphone. In the flipped class, students were not given a lecture, but were asked to solve short questions displayed on screen, to make a short presentation about a part of the video lecture, and to discuss a critical question related to the main subject of the day. An additional team-based learning (TBL) session with individual and group answers was implemented. The average individual scores were considerably higher in the last two years, when the flipped method was implemented, than in the three previous years when conventional lectures were used. The following learning concepts were discussed: the role of the flipped method as an active learning strategy, the efficacy of lecture videos and short questions, students' participation in the class discussion, present-day value of the method, cooperation with TBL, the significance of active learning in relation with the students' learning ability, and the potential increase in the preparation time and workload for students.

  19. Flipped classroom model for learning evidence-based medicine

    Directory of Open Access Journals (Sweden)

    Rucker SY

    2017-08-01

    Full Text Available Sydney Y Rucker,1 Zulfukar Ozdogan,1 Morhaf Al Achkar2 1School of Education, Indiana University, Bloomington, IN, 2Department of Family Medicine, School of Medicine, University of Washington, Seattle, WA, USA Abstract: Journal club (JC, as a pedagogical strategy, has long been used in graduate medical education (GME. As evidence-based medicine (EBM becomes a mainstay in GME, traditional models of JC present a number of insufficiencies and call for novel models of instruction. A flipped classroom model appears to be an ideal strategy to meet the demands to connect evidence to practice while creating engaged, culturally competent, and technologically literate physicians. In this article, we describe a novel model of flipped classroom in JC. We present the flow of learning activities during the online and face-to-face instruction, and then we highlight specific considerations for implementing a flipped classroom model. We show that implementing a flipped classroom model to teach EBM in a residency program not only is possible but also may constitute improved learning opportunity for residents. Follow-up work is needed to evaluate the effectiveness of this model on both learning and clinical practice. Keywords: evidence-based medicine, flipped classroom, residency education

  20. What millennial medical students say about flipped learning

    Directory of Open Access Journals (Sweden)

    Pettit RK

    2017-07-01

    Full Text Available Robin K Pettit, Lise McCoy, Marjorie Kinney School of Osteopathic Medicine in Arizona, A. T. Still University, Mesa, AZ, USA Abstract: Flipped instruction is gaining popularity in medical schools, but there are unanswered questions such as the optimum amount of the curriculum to flip and whether flipped sessions should be mandatory. We were in a unique position to evaluate feedback from first-year medical students who had experienced both flipped and lecture-based courses during their first semester of medical school. A key finding was that the students preferred a variety of different learning formats over an “all or nothing” learning format. Learning format preferences did not necessarily align with perceptions of which format led to better course exam performance. Nearly 70% of respondents wanted to make their own decisions regarding attendance. Candid responses to open-ended survey prompts reflected millennial preferences for choice, flexibility, efficiency, and the ability to control the pace of their learning, providing insight to guide ­curricular improvements. Keywords: flipped classroom, mandatory attendance, medical education, lecture-based, variety

  1. Developments of optimum flip-chip bonding process

    Science.gov (United States)

    Jang, Dong H.; Kang, Sa Y.; Lee, Y. M.; Oh, S. Y.

    1997-08-01

    Flip-chip soldering is the critical technology for solving the current issues of electronic packaging industries that require the high I/O's. In order to increase the manufacturing ability of flip-chip technology, however, yield and reliability tissues should overcome. In this study, optimum flip-chip bonding process has been developed by using the test chips that had the electroplated solder bumps. Test chips are composed of three different types that are i) peripheral array pad chip, ii) peripheral array pad chip, and iii) area array pad chip. Each test chip has the daisy chain to consider the effect of reliability test. The electrical resistance was measured before and after reliability test. Based on these measurement, failure mode resulted from the moisture absorption was studied using scanning acoustic microscope. To achieve an optimum reflow profile of solder bump, correct temperature profile was set up with respect to the resin base flux. Different bonding forces were tested. Four underfill encapsulants were evaluated for minimum voids that caused the severe defects after reliability test. Also, the gap heights were measured with respect to applied bonding force after underfill was performed. Results from the moisture absorption and thermal cycling were discussed for flip-chip bonding on BT-resin substrates. The test vehicles using flip-chip technology have passed moisture preconditioning and temperature cycling tests.

  2. Experiences in flip chip production of radiation detectors

    Science.gov (United States)

    Savolainen-Pulli, Satu; Salonen, Jaakko; Salmi, Jorma; Vähänen, Sami

    2006-09-01

    Modern imaging devices often require heterogeneous integration of different materials and technologies. Because of yield considerations, material availability, and various technological limitations, an extremely fine pitch is necessary to realize high-resolution images. Thus, there is a need for a hybridization technology that is able to join together readout amplifiers and pixel detectors at a very fine pitch. This paper describes radiation detector flip chip production at VTT. Our flip chip technology utilizes 25-μm diameter tin-lead solder bumps at a 50-μm pitch and is based on flux-free bonding. When preprocessed wafers are used, as is the case here, the total yield is defined only partly by the flip chip process. Wafer preprocessing done by a third-party silicon foundry and the flip chip process create different process defects. Wafer-level yield maps (based on probing) provided by the customer are used to select good readout chips for assembly. Wafer probing is often done outside of a real clean room environment, resulting in particle contamination and/or scratches on the wafers. Factors affecting the total yield of flip chip bonded detectors are discussed, and some yield numbers of the process are given. Ways to improve yield are considered, and finally guidelines for process planning and device design with respect to yield optimization are given.

  3. Experiences in flip chip production of radiation detectors

    Energy Technology Data Exchange (ETDEWEB)

    Savolainen-Pulli, Satu [VTT, MEMS- and Micropackaging, P.O. Box 1000, Tietotie 3, Espoo, FI-02044 VTT (Finland)]. E-mail: satu.savolainen-pulli@vtt.fi; Salonen, Jaakko [VTT, MEMS- and Micropackaging, P.O. Box 1000, Tietotie 3, Espoo, FI-02044 VTT (Finland); Salmi, Jorma [VTT, MEMS- and Micropackaging, P.O. Box 1000, Tietotie 3, Espoo, FI-02044 VTT (Finland); Vaehaenen, Sami [VTT, MEMS- and Micropackaging, P.O. Box 1000, Tietotie 3, Espoo, FI-02044 VTT (Finland)

    2006-09-01

    Modern imaging devices often require heterogeneous integration of different materials and technologies. Because of yield considerations, material availability, and various technological limitations, an extremely fine pitch is necessary to realize high-resolution images. Thus, there is a need for a hybridization technology that is able to join together readout amplifiers and pixel detectors at a very fine pitch. This paper describes radiation detector flip chip production at VTT. Our flip chip technology utilizes 25-{mu}m diameter tin-lead solder bumps at a 50-{mu}m pitch and is based on flux-free bonding. When preprocessed wafers are used, as is the case here, the total yield is defined only partly by the flip chip process. Wafer preprocessing done by a third-party silicon foundry and the flip chip process create different process defects. Wafer-level yield maps (based on probing) provided by the customer are used to select good readout chips for assembly. Wafer probing is often done outside of a real clean room environment, resulting in particle contamination and/or scratches on the wafers. Factors affecting the total yield of flip chip bonded detectors are discussed, and some yield numbers of the process are given. Ways to improve yield are considered, and finally guidelines for process planning and device design with respect to yield optimization are given.

  4. An Experiential Learning Perspective on Students’ Satisfaction Model in a Flipped Classroom Context

    National Research Council Canada - National Science Library

    Xuesong Zhai; Jibao Gu; Hefu Liu; Jyh-Chong Liang; Chin-Chung Tsai

    2017-01-01

    ...’ perceptions of flipped settings. In order to fill this gap, in this study, a students’ satisfaction model for the flipped classroom was constructed based on the experiential learning theory...

  5. Electroplated solder alloys for flip chip interconnections

    Science.gov (United States)

    Annala, P.; Kaitila, J.; Salonen, J.

    1997-01-01

    Flip chip mounting of bare dice is gaining widespread use in microelectronics packaging. The main drivers for this technology are high packaging density, improved performance at high frequency, low parasitic effects and potentially high reliability and low cost. Many companies have made significant efforts to develop a technology for bump processing, bare die testing and underfill encapsulation to gain the benefit of all potential advantages. We have focussed on low cost bumping of fully processed silicon wafers to develop a flexible scheme for various reflow requirements. The bumping process is based on galvanic plating from an alloy solution or, alternatively, from several elemental plating baths. Sputtered Mo/Cu or Cr/Cu is used as a wettable base for electroplating. Excess base metal is removed by using the bumps as an etching mask. Variation of the alloy composition or the layer structure, allows the adjustment of the bump reflow temperature for the specific requirements of the assembly. Using binary tin-lead and ternary tin-lead-bismuth alloys, reflow temperatures from 100 °C (bismuth rich alloys) to above 300 °C (lead rich alloys) can be covered. The influence of the plating current density on the final alloy composition has been established by ion beam analysis of the plated layers and a series of reflow experiments. To control the plating uniformity and the alloy composition, a new cup plating system has been built with a random flow pattern and continuous adjustment of the current density. A well-controlled reflow of the bumps has been achieved in hot glycerol up to the eutectic point of tin-lead alloys. For high temperature alloys, high molecular weight organic liquids have been used. A tensile pull strength of 20 g per bump and resistance of 5 mΩ per bump have been measured for typical eutectic tin-lead bumps of 100 μm in diameter.

  6. Using 3DClass To Flip Biochemistry Classroom

    Directory of Open Access Journals (Sweden)

    T. Silva

    2014-08-01

    Full Text Available The flipped classroom inverts traditional teaching methods, in order to have studentsprepared for topics and techniques covered in the following meeting. This approach wasadopted in a biochemistry course taught to biology freshmen students at the University ofCampinas, using a Virtual Learning Environment called 3DClass. Before each classroomsession, a quiz was delivered covering the following topic and students were allowed totake quizzes as many times as they wanted. This approach was utilized in order to betterprepare students in classes and to perform lab experiments. Every student attempt wasrecorded in a database. Before each classroom session, the instructors were provided witha summary of the class answers, highlighting questions where students had more difficultyand the ones that scored higher. This kind of information was helpful to design activities tocover the topics where students had more difficulties. Based on the 3DClass records thestudents behaviors were mapped, such as students taking the quizzes seriously, studentsguessing, students answering a quiz until scoring 100%, students that continue answeringafter scoring 100% in order to increase their grades, students that never score 100%.However, the most relevant information 3DClass brought us was the possibility to identifystudent’s confidence in their answers, which could be observed by the analysis of theirattempts for each question. If they had made different choices each try, it would haveindicated a low confidence level, while always providing the same answer indicated ahigher confidence level, even whilst picking incorrect answers. This experiment haverevealed that students coming to the classroom better prepared reflected positively on thedeveloped activities, but the number of students taking the quizzes seriously were not asgreat as we had expected, indicating that more actions should be taken to improvestudents engagement with these activities.

  7. Assessing temperature changes in cortical bone using variable flip-angle ultrashort echo-time MRI

    Science.gov (United States)

    Han, Misung; Scott, Serena J.; Ozhinsky, Eugene; Salgaonakar, Vasant A.; Jones, Peter D.; Larson, Peder E. Z.; Diederich, Chris J.; Rieke, Viola; Krug, Roland

    2017-03-01

    MR-guided high-intensity focused ultrasound ablation is a promising, noninvasive method for treatment of bone tumors and palliation of pain. During thermal therapy, temperature mapping is necessary to ensure proper heat deposition in targeted tumors as well as to prevent unnecessary heating in surrounding tissues. Conventional MR thermometry exploits the proton resonant frequency shift of water protons, which normally requires a long echo time; therefore, this method is not appropriate for cortical bone due to its short T2* relaxation time. This work demonstrates that ultrashort echo-time MRI can characterize T1 changes in cortical bone caused by temperature changes. Ex vivo experiments were performed to heat diaphysis segments of bovine femurs with an interstitial ultrasound applicator. The T1 increase in the heated parts of cortical bone was observed. The temerature dependence of T1 in cortical born was also assessed by heating bovine bone samples in a temperature-controlled water bath. T1 mapping of cortical bone enabled by ultrashort echo-time MRI might allow for more accurate characterization of thermal dose during treatment of bone tumors.

  8. High flip angle imaging of metallic stents: Implications for MR angiography and intraluminal signal interpretation

    NARCIS (Netherlands)

    Brück, E.H.; van Holten, J.; Wielopolski, P.; Pattynama, P.M.T.; van Dijk, L.C.

    2003-01-01

    Intraluminal stent signal characterization by MRI is generally hampered by signal loss from the metallic stent material. This signal loss is related to magnetic susceptibility and RF shielding. Even when stent materials with low magnetic susceptibility are used, RF shielding can still be problematic

  9. Flipped Instruction in a High School Science Classroom

    Science.gov (United States)

    Leo, Jonathan; Puzio, Kelly

    2016-10-01

    This paper reports on a quasi-experimental study examining the effectiveness of flipped instruction in a 9th grade biology classroom. This study included four sections of freshmen-level biology taught by the first author at a private secondary school in the Pacific Northwest. Using a block randomized design, two sections were flipped and two remained traditional. The quiz and posttest data were adjusted for pretest differences using ANCOVA. The results suggest that flipped instruction had a positive effect student achievement, with effect sizes ranging from +0.16 to +0.44. In addition, some students reported that they preferred watching video lectures outside of class and appreciated more active approaches to learning.

  10. Out of Classroom Instruction in the Flipped Classroom

    DEFF Research Database (Denmark)

    Triantafyllou, Evangelia; Timcenko, Olga

    2015-01-01

    This article presents experiences and student perceptions on the introduction of the flipped classroom model in two consecutive semesters at Media Technology department of Aalborg University, Copenhagen, Denmark. We introduced the flipped instruction model to a statistics course and a mathematics...... workshop. We collected data by two online survey studies, which show support for student perceptions that out-of-classroom instruction with online resources enhances learning, by providing visual and in depth explanations, and can engage the learner. However, students stated that they miss just......-in-time explanations when learning with online resources and they questioned the quality and validity of some of them. Based on these findings and our own experience, we discuss requirements for resources and activities in flipped classrooms in order for the student to engage and learn. Finally, we present a framework...

  11. Graphene Layer Growth Chemistry: Five-Six-Ring Flip Reaction

    Energy Technology Data Exchange (ETDEWEB)

    Whitesides, R.; Domin, D.; Salomon-Ferrer, R.; Lester Jr., W.A.; Frenklach, M.

    2007-12-01

    Reaction pathways are presented for hydrogen-mediated isomerization of a five and six member carbon ring complex on the zigzag edge of a graphene layer. A new reaction sequence that reverses orientation of the ring complex, or 'flips' it, was identified. Competition between the flip reaction and 'ring separation' was examined. Ring separation is the reverse of the five and six member ring complex formation reaction, previously reported as 'ring collision'. The elementary steps of the pathways were analyzed using density-functional theory (DFT). Rate coefficients were obtained by solution of the energy master equation and classical transition state theory utilizing the DFT energies, frequencies, and geometries. The results indicate that the flip reaction pathway dominates the separation reaction and should be competitive with other pathways important to the graphene zigzag edge growth in high temperature environments.

  12. Spin flip of multiqubit states in discrete phase space

    Science.gov (United States)

    Srinivasan, K.; Raghavan, G.

    2017-02-01

    Time reversal and spin flip are discrete symmetry operations of substantial importance to quantum information and quantum computation. Spin flip arises in the context of separability, quantification of entanglement and the construction of universal NOT gates. The present work investigates the relationship between the quantum state of a multiqubit system represented by the discrete Wigner function (DWFs) and its spin-flipped counterpart. The two are shown to be related through a Hadamard matrix that is independent of the choice of the quantum net used for the tomographic reconstruction of the DWF. These results are of interest to cases involving the direct tomographic reconstruction of the DWF from experimental data, and in the analysis of entanglement related properties purely in terms of the DWF.

  13. Fully simulatable quantum-secure coin-flipping and applications

    DEFF Research Database (Denmark)

    Lunemann, Carolin; Nielsen, Jesper Buus

    2011-01-01

    We propose a coin-flip protocol which yields a string of strong, random coins and is fully simulatable against poly-sized quantum adversaries on both sides. It can be implemented with quantum-computational security without any set-up assumptions, since our construction only assumes mixed commitment...... schemes which we show how to construct in the given setting. We then show that the interactive generation of random coins at the beginning or during outer protocols allows for quantum-secure realizations of classical schemes, again without any set-up assumptions. As example applications we discuss quantum...... zero-knowledge proofs of knowledge and quantum-secure two-party function evaluation. Both applications assume only fully simulatable coin-flipping and mixed commitments. Since our framework allows to construct fully simulatable coin-flipping from mixed commitments, this in particular shows that mixed...

  14. Two-Bit Bit Flipping Decoding of LDPC Codes

    CERN Document Server

    Nguyen, Dung Viet; Marcellin, Michael W

    2011-01-01

    In this paper, we propose a new class of bit flipping algorithms for low-density parity-check (LDPC) codes over the binary symmetric channel (BSC). Compared to the regular (parallel or serial) bit flipping algorithms, the proposed algorithms employ one additional bit at a variable node to represent its "strength." The introduction of this additional bit increases the guaranteed error correction capability by a factor of at least 2. An additional bit can also be employed at a check node to capture information which is beneficial to decoding. A framework for failure analysis of the proposed algorithms is described. These algorithms outperform the Gallager A/B algorithm and the min-sum algorithm at much lower complexity. Concatenation of two-bit bit flipping algorithms show a potential to approach the performance of belief propagation (BP) decoding in the error floor region, also at lower complexity.

  15. The flipped classroom for professional development: part I. Benefits and strategies.

    Science.gov (United States)

    McDonald, Katie; Smith, Charlene M

    2013-10-01

    Individualizing the educational encounter is supported by flipping the classroom experience. This column offers an overview and describes the benefits of flipping the classroom. Part II will explore the practicalities and pedagogy of lecture capture using podcasts and videos, a technology strategy used in flipping the classroom.

  16. [Evaluation of flipped classroom teaching model in undergraduates education of oral and maxillofacial surgery].

    Science.gov (United States)

    Cai, Ming; Cao, Xia; Fang, Xiao; Wang, Xu-dong; Zhang, Li-li; Zheng, Jia-wei; Shen, Guo-fang

    2015-12-01

    Flipped classroom is a new teaching model which is different from the traditional teaching method. The history and characteristics of flipped classroom teaching model were introduced in this paper. A discussion on how to establish flipped classroom teaching protocol in oral and maxillofacial surgery education was carried out. Curriculum transformation, construction of education model and possible challenges were analyzed and discussed.

  17. Scaffolded Semi-Flipped General Chemistry Designed to Support Rural Students' Learning

    Science.gov (United States)

    Lenczewski, Mary S.

    2016-01-01

    Students who lack academic maturity can sometimes feel overwhelmed in a fully flipped classroom. Here an alternative, the Semi-Flipped method, is discussed. Rural students, who face unique challenges in transitioning from high school learning to college-level learning, can particularly profit from the use of the Semi-Flipped method in the General…

  18. K-12 Teacher Perceptions Regarding the Flipped Classroom Model for Teaching and Learning

    Science.gov (United States)

    Gough, Evan; DeJong, David; Grundmeyer, Trent; Baron, Mark

    2017-01-01

    A great deal of evidence can be cited from higher education literature on the effectiveness of the flipped classroom; however, very little research was discovered on the flipped classroom at the K-12 level. This study examined K-12 teachers' perceptions regarding the flipped classroom and differences in teachers' perceptions based on grade level…

  19. Present Research on the Flipped Classroom and Potential Tools for the EFL Classroom

    Science.gov (United States)

    Mehring, Jeff

    2016-01-01

    The flipped classroom can support the implementation of a communicative, student-centered learning environment in the English as a foreign language classroom. Unfortunately, there is little research which supports the incorporation of flipped learning in the English as a foreign language classroom. Numerous studies have focused on flipped learning…

  20. Identifying Professional Competencies of the Flip-Chip Packaging Engineer in Taiwan

    Science.gov (United States)

    Guu, Y. H.; Lin, Kuen-Yi; Lee, Lung-Sheng

    2014-01-01

    This study employed a literature review, expert interviews, and a questionnaire survey to construct a set of two-tier competencies for a flip-chip packaging engineer. The fuzzy Delphi questionnaire was sent to 12 flip-chip engineering experts to identify professional competencies that a flip-chip packaging engineer must have. Four competencies,…

  1. Student learning and perceptions in a flipped linear algebra course

    Science.gov (United States)

    Love, Betty; Hodge, Angie; Grandgenett, Neal; Swift, Andrew W.

    2014-04-01

    The traditional lecture style of teaching has long been the norm in college science, technology, engineering, and mathematics (STEM) courses, but an innovative teaching model, facilitated by recent advances in technology, is gaining popularity across college campuses. This new model inverts or 'flips' the usual classroom paradigm, in that students learn initial course concepts outside of the classroom, while class time is reserved for more active problem-based learning and practice activities. While the flipped classroom model shows promise for improving STEM learning and increasing student interest in STEM fields, discussions to date of the model and its impact are more anecdotal than data driven - very little research has been undertaken to rigorously assess the potential effects on student learning that can result from the flipped classroom environment. This study involved 55 students in 2 sections of an applied linear algebra course, using the traditional lecture format in one section and the flipped classroom model in another. In the latter, students were expected to prepare for the class in some way, such as watching screencasts prepared by the instructor, or reading the textbook or the instructor's notes. Student content understanding and course perceptions were examined. Content understanding was measured by the performance on course exams, and students in the flipped classroom environment had a more significant increase between the sequential exams compared to the students in the traditional lecture section, while performing similarly in the final exam. Course perceptions were represented by an end-of-semester survey that indicated that the flipped classroom students were very positive about their experience in the course, and particularly appreciated the student collaboration and instructional video components.

  2. All-optical flip-flop and control methods thereof

    Science.gov (United States)

    Maywar, Drew; Agrawal, Govind P.

    2010-03-23

    Embodiments of the invention pertain to remote optical control of holding beam-type, optical flip-flop devices, as well as to the devices themselves. All-optical SET and RE-SET control signals operate on a cw holding beam in a remote manner to vary the power of the holding beam between threshold switching values to enable flip-flop operation. Cross-gain modulation and cross-polarization modulation processes can be used to change the power of the holding beam.

  3. Flipped version of the supersymmetric strongly coupled preon model

    Science.gov (United States)

    Fajfer, S.; Mileković, M.; Tadić, D.

    1989-12-01

    In the supersymmetric SU(5) [SUSY SU(5)] composite model (which was described in an earlier paper) the fermion mass terms can be easily constructed. The SUSY SU(5)⊗U(1), i.e., flipped, composite model possesses a completely analogous composite-particle spectrum. However, in that model one cannot construct a renormalizable superpotential which would generate fermion mass terms. This contrasts with the standard noncomposite grand unified theories (GUT's) in which both the Georgi-Glashow electrical charge embedding and its flipped counterpart lead to the renormalizable theories.

  4. A new angle on the Euler angles

    Science.gov (United States)

    Markley, F. Landis; Shuster, Malcolm D.

    1995-01-01

    We present a generalization of the Euler angles to axes beyond the twelve conventional sets. The generalized Euler axes must satisfy the constraint that the first and the third are orthogonal to the second; but the angle between the first and third is arbitrary, rather than being restricted to the values 0 and pi/2, as in the conventional sets. This is the broadest generalization of the Euler angles that provides a representation of an arbitrary rotation matrix. The kinematics of the generalized Euler angles and their relation to the attitude matrix are presented. As a side benefit, the equations for the generalized Euler angles are universal in that they incorporate the equations for the twelve conventional sets of Euler angles in a natural way.

  5. Nasolacrimal system: evaluation with gadolinium-enhanced MR dacryocystography with a three-dimensional fast spoiled gradient-recalled technique

    Energy Technology Data Exchange (ETDEWEB)

    Karaguelle, Tuba; Erden, Ayse; Erden, Ilhan [Department of Radiology, Medical School, Ankara University, Sihhiye, 06100 Ankara (Turkey); Zilelioglu, Gueler [Department of Ophthalmology, Medical School, Ankara University, Sihhiye, 06100 Ankara (Turkey)

    2002-09-01

    The aim of this study was to determine the diagnostic accuracy of gadolinium-enhanced three-dimensional (3D) fast spoiled gradient-recalled (FSPGR) MR dacryocystography in patients with epiphora. Bilateral nasolacrimal systems of 19 patients suspected of having nasolacrimal canal obstruction were evaluated with MR dacryocystography. A sterile 0.9% NaCl solution containing 1:100 diluted gadolinium chelate was instilled into the bilateral conjunctival sacs of the patients. The 3D FSPGR sequence was used with 1.0-T scanner with the following parameters: TR 9.3 ms; TE 2 ms; flip angle 20; 256 x 224 matrix; 13- or 26-cm field of view; and 1-mm slice thickness. Seventeen patients had digital dacryocystography for comparison which we considered standard of reference. Thirty-four nasolacrimal systems were evaluated with MR and digital dacryocystography. Discrepancies between the findings of both methods were detected in 2 patients. The overall sensitivity of MR in detecting the obstruction was 100%. Magnetic resonance helped to determine the canalicular and ductal obstruction in 100% of the patients and the saccular obstruction in 80% of the patients. We conclude that 3D FSGR technique for MR dacryocystography is a reliable and noninvasive method in the evaluation of the obstruction level in the lacrimal system in patients with epiphora. (orig.)

  6. Glaucoma, Open-Angle

    Science.gov (United States)

    ... Programs Home > Statistics and Data > Glaucoma, Open-angle Glaucoma, Open-angle Open-angle Glaucoma Defined In open-angle glaucoma, the fluid passes ... 2010 2010 U.S. Age-Specific Prevalence Rates for Glaucoma by Age and Race/Ethnicity The prevalence of ...

  7. Evaluation of small ({<=}2 cm) dysplastic nodules and well-differentiated hepatocellular carcinomas with ferucarbotran-enhanced MRI in a 1.0-T MRI unit: Utility of T2*-weighted gradient echo sequences with an intermediate-echo time

    Energy Technology Data Exchange (ETDEWEB)

    Tonan, Tatsuyuki [Department of Radiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011 (Japan); Fujimoto, Kiminori [Department of Radiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011 (Japan)], E-mail: kimichan@med.kurume-u.ac.jp; Azuma, Sanae [Department of Radiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011 (Japan); Ono, Noriyuki [Department of Internal Medicine, Chikugo City Hospital, Chikugo (Japan); Matsushita, Sunao [Department of Radiology, Chikugo City Hospital, 917-1 Izumi, Chikugo 833-0041 (Japan); Kojiro, Masamichi [Department of Pathology, Kurume University School of Medicine, Kurume (Japan); Hayabuchi, Naofumi [Department of Radiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011 (Japan)

    2007-10-15

    Purpose: To evaluate the detectability and signal intensities of small ({<=}2 cm) dysplastic nodules (DNs) and well-differentiated hepatocellular carcinomas (w-HCCs) by T2*-weighted gradient echo (GRE) sequences using an intermediate echo-time (TE) with ferucarbotran in a 1.0-T magnetic resonance imaging (MRI) unit. Materials and methods: Pathologically confirmed DNs (n = 13) and w-HCCs (n = 31) with a median largest dimension of 1.1 cm were scanned using ferucarbotran-enhanced MRI. Conventional T2*-weighted GRE sequences (conventional-T2*-GRE: repetition time, 280 ms; echo time, 14 ms; flip angle, 60 deg.) and specific T2*-weighted GRE sequences using an intermediate-TE (specific-T2*-GRE: repetition time, 140 ms; echo time, 8 ms; flip angle, 30 deg.) were obtained before and after ferucarbotran administration. Two independent observers scored all nodules for visibility and assigned confidence level scores to their observations. To assess the effect of ferucarbotran, the tumor-liver signal contrast-to-noise ratio (tumor-liver-CNR) was also calculated for detected nodules by the same two observers with consensus. Results: There was good interobserver agreement regarding the presence of nodules for both sequence types. Qualitative and quantitative analyses indicated that specific-T2*GRE sequences were superior to conventional-T2*-GRE sequences for detecting DNs and w-HCCs with hypointense signals. The tumor-liver-CNR of DNs was significantly different between specific-T2*-GRE sequences and conventional-T2*-GRE sequences (Mann-Whitney test, P < 0.001). Both qualitative and quantitative analyses indicated that conventional-T2*-GRE sequences were superior to specific-T2*-GRE sequences for detecting w-HCCs with heterogeneous and hyperintense signals. Conclusion: Specific-T2*-GRE sequences with ferucarbotran are useful for detecting DNs and w-HCCs that produce hypointense signals on a 1.0-T MRI unit.

  8. Flipping the Science Classroom: Exploring Merits, Issues and Pedagogy

    Science.gov (United States)

    Ng, Wan

    2014-01-01

    Educators are continually being challenged to think about how best to integrate digital technologies meaningfully and effectively in their classrooms. A current trend in educational technology which has the potential to enable this in a pragmatic manner is the flipped classroom concept. This paper aims to explore the idea in Science teaching and…

  9. Case Study: Student-Produced Videos for the Flipped Classroom

    Science.gov (United States)

    Prud'homme-Genereux, Annie

    2016-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue describes a way of building a library of student-produced videos to use in the flipped classroom.

  10. Adult Students' Experiences of a Flipped Mathematics Classroom

    Science.gov (United States)

    Larsen, Judy

    2015-01-01

    The flipped classroom is a flexible blended learning model that is growing in popularity due to the emergent accessibility to online content delivery technology. By delivering content outside of class time asynchronously, teachers are able to dedicate their face to face class time for student-centred teaching approaches. The flexibility in…

  11. Implementation and Critical Assessment of the Flipped Classroom Experience

    Science.gov (United States)

    Scheg, Abigail G., Ed.

    2015-01-01

    In the past decade, traditional classroom teaching models have been transformed in order to better promote active learning and learner engagement. "Implementation and Critical Assessment of the Flipped Classroom Experience" seeks to capture the momentum of non-traditional teaching methods and provide a necessary resource for individuals…

  12. Successful EFL Teaching Using Mobile Technologies in a Flipped Classroom

    Science.gov (United States)

    Obari, Hiroyuki; Lambacher, Stephen

    2015-01-01

    Two case studies evaluating the effectiveness of a flipped classroom compared to a traditional classroom were performed. The studies were conducted from April 2014 to January 2015 at a private university in Tokyo, targeting 60 first-year and 25 third-year undergraduates, respectively. In the first study, an assessment of pre- and post-treatment…

  13. On flipping the classroom in large first year calculus courses

    Science.gov (United States)

    Jungić, Veselin; Kaur, Harpreet; Mulholland, Jamie; Xin, Cindy

    2015-05-01

    Over the course of two years, 2012--2014, we have implemented a 'flipping' the classroom approach in three of our large enrolment first year calculus courses: differential and integral calculus for scientists and engineers. In this article we describe the details of our particular approach and share with the reader some experiences of both instructors and students.

  14. Microlectures in a Flipped Classroom: Application, Creation and Resources

    Science.gov (United States)

    Sweet, Dawn

    2014-01-01

    Using microlectures in a flipped classroom is a growing trend. In this media review, the benefits of microlectures for such classrooms are discussed, including how they can be used to help students become more responsible for their learning, as well as how they can be used by teachers to provide differentiated instruction. A list of resources for…

  15. Reflections on a Flipped Classroom in First Year Higher Education

    Science.gov (United States)

    McCarthy, Josh

    2016-01-01

    This paper explores the efficacy of a flipped classroom model for teaching first year students three-dimensional (3D) animation, and analyses the advantages and disadvantages when compared to traditional teaching mechanisms. In 2015, within the course "Introduction to CGI" at the University of South Australia, two different tutorial…

  16. Using Digital Learning Platforms to Extend the Flipped Classroom

    Science.gov (United States)

    Balzotti, Jonathan M.; McCool, Lynn B.

    2016-01-01

    Although digital environments already play a vital role in the flipped classroom model, this research project shows that in university writing classrooms, innovative content design and delivery systems can extend the walls of the classroom to areas beyond, in which students transfer and connect course content with the professional world. In this…

  17. Inquiry-Based Learning and the Flipped Classroom Model

    Science.gov (United States)

    Love, Betty; Hodge, Angie; Corritore, Cynthia; Ernst, Dana C.

    2015-01-01

    The flipped classroom model of teaching can be an ideal venue for turning a traditional classroom into an engaging, inquiry-based learning (IBL) environment. In this paper, we discuss how two instructors at different universities made their classrooms come to life by moving the acquisition of basic course concepts outside the classroom and using…

  18. Flipping & Clicking Your Way to Higher-Order Learning

    Science.gov (United States)

    Garver, Michael S.; Roberts, Brian A.

    2013-01-01

    This innovative system of teaching and learning includes the implementation of two effective learning technologies: podcasting ("flipping") and classroom response systems ("clicking"). Students watch lectures in podcast format before coming to class, which allows the "entire" class period to be devoted to active…

  19. Using Flip Camcorders for Active Classroom Metacognitive Reflection

    Science.gov (United States)

    Hargis, Jace; Marotta, Sebastian M.

    2011-01-01

    A Center for Teaching and Learning provided Flip camcorders to a group of 10 new faculty members, who were asked to use this teaching tool in their classroom instruction. The classes included mathematics, political science, computer engineering, psychology, business, music and dance. The qualitative results indicate that all faculty members and…

  20. University and Flipped Learning TIC & DIL Project: Framework and Design

    Science.gov (United States)

    Pinnelli, Stefania; Fiorucci, Andrea

    2015-01-01

    The flipped classroom approach (FC) is for the educational world a chance of recovery and improvement of pedagogical student-centered model and collaborative teaching methods aimed at optimizing the time resource and to promote personalization and self-learning in a perspective of autonomy. The paper moving from a pedagogical reflection on…

  1. Fermion helicity flip in higher-derivative electromagnetism

    Energy Technology Data Exchange (ETDEWEB)

    Accioly, A.J. [Instituto de Fisica Teorica (IFT), Sao Paulo, SP (Brazil); Mukai, H. [Universidade Estadual de Maringa, PR (Brazil). Dept. de Fisica

    1996-10-01

    It is shown that massive fermions have their helicity flipped on account of their interaction with an electromagnetic field described by Podolsky`s generalized electrodynamics. Massless fermions, in turn, seem to be unaffected by the electromagnetic field as far as their helicity is concerned. (author).

  2. On Flipping the Classroom in Large First Year Calculus Courses

    Science.gov (United States)

    Jungic, Veselin; Kaur, Harpreet; Mulholland, Jamie; Xin, Cindy

    2015-01-01

    Over the course of two years, 2012-2014, we have implemented a "flipping" the classroom approach in three of our large enrolment first year calculus courses: differential and integral calculus for scientists and engineers. In this article we describe the details of our particular approach and share with the reader some experiences of…

  3. The Effectiveness of a Technology-Enhanced Flipped Science Classroom

    Science.gov (United States)

    Sezer, Baris

    2017-01-01

    This study examined the effect on the learning and motivation of students of a flipped classroom environment enriched with technology. A mixed research design using a pretest or posttest experimental model, combined with qualitative data, was conducted in a public middle school in Turkey for 2 weeks (three class hours) within a science course.…

  4. On Flipping the Classroom in Large First Year Calculus Courses

    Science.gov (United States)

    Jungic, Veselin; Kaur, Harpreet; Mulholland, Jamie; Xin, Cindy

    2015-01-01

    Over the course of two years, 2012-2014, we have implemented a "flipping" the classroom approach in three of our large enrolment first year calculus courses: differential and integral calculus for scientists and engineers. In this article we describe the details of our particular approach and share with the reader some experiences of…

  5. Can Flipping the Classroom Work? Evidence from Undergraduate Chemistry

    Science.gov (United States)

    Casasola, Timothy; Nguyen, Tutrang; Warschauer, Mark; Schenke, Katerina

    2017-01-01

    Our study describes student outcomes from an undergraduate chemistry course that implemented a flipped format: a pedagogical model that consists of students watching recorded video lectures outside of the classroom and engaging in problem solving activities during class. We investigated whether (1) interest, study skills, and attendance as…

  6. Preparing Students for Flipped or Team-Based Learning Methods

    Science.gov (United States)

    Balan, Peter; Clark, Michele; Restall, Gregory

    2015-01-01

    Purpose: Teaching methods such as Flipped Learning and Team-Based Learning require students to pre-learn course materials before a teaching session, because classroom exercises rely on students using self-gained knowledge. This is the reverse to "traditional" teaching when course materials are presented during a lecture, and students are…

  7. Periodicals Price Survey 2002: Doing the Digital Flip.

    Science.gov (United States)

    Van Orsdel, Lee; Born, Kathleen

    2002-01-01

    Presents the annual periodicals price study. Highlights include average prices; cost histories; cost projections for future budgeting; electronic journal issues; flip pricing, defined as online access at the core of pricing negotiations; various pricing models; purchasing print at deeply discounted prices; and current trends in pricing and in the…

  8. The Flipped Classroom Model: When Technology Enhances Professional Skills

    Science.gov (United States)

    Baytiyeh, Hoda

    2017-01-01

    Purpose: The purpose of this paper is to investigate the effectiveness of the flipped classroom model in teaching and learning as well as the skills that can be acquired by students after being exposed to this learning style. Design/methodology/approach: This paper uses a qualitative case study design. In total, 20 students, from various majors,…

  9. Student Learning and Perceptions in a Flipped Linear Algebra Course

    Science.gov (United States)

    Love, Betty; Hodge, Angie; Grandgenett, Neal; Swift, Andrew W.

    2014-01-01

    The traditional lecture style of teaching has long been the norm in college science, technology, engineering, and mathematics (STEM) courses, but an innovative teaching model, facilitated by recent advances in technology, is gaining popularity across college campuses. This new model inverts or "flips" the usual classroom paradigm, in…

  10. Using Flip Camcorders for Active Classroom Metacognitive Reflection

    Science.gov (United States)

    Hargis, Jace; Marotta, Sebastian M.

    2011-01-01

    A Center for Teaching and Learning provided Flip camcorders to a group of 10 new faculty members, who were asked to use this teaching tool in their classroom instruction. The classes included mathematics, political science, computer engineering, psychology, business, music and dance. The qualitative results indicate that all faculty members and…

  11. The Flipped Classroom Model: When Technology Enhances Professional Skills

    Science.gov (United States)

    Baytiyeh, Hoda

    2017-01-01

    Purpose: The purpose of this paper is to investigate the effectiveness of the flipped classroom model in teaching and learning as well as the skills that can be acquired by students after being exposed to this learning style. Design/methodology/approach: This paper uses a qualitative case study design. In total, 20 students, from various majors,…

  12. Homoclinic Bifurcation of Orbit Flip with Resonant Principal Eigenvalues

    Institute of Scientific and Technical Information of China (English)

    Tian Si ZHANG; De Ming ZHU

    2006-01-01

    Codimension-3 bifurcations of an orbit-flip homoclinic orbit with resonant principal eigenvalues are studied for a four-dimensional system. The existence, number, co-existence and non-coexistence of 1-homoclinic orbit, 1-periodic orbit, 2n-homoclinic orbit and 2n-periodic orbit are obtained. The bifurcation surfaces and existence regions are also given.

  13. Degenerate Orbit Flip Homoclinic Bifurcations with Higher Dimensions

    Institute of Scientific and Technical Information of China (English)

    Ran Chao WU; Jian Hua SUN

    2006-01-01

    Bifurcations of a degenerate homoclinic orbit with orbit flip in high dimensional system are existence and uniqueness of 1-homoclinic orbit and 1-periodic orbit are given. Also considered is the existence of 2-homoclinic orbit and 2-periodic orbit. In additon, the corresponding bifurcation surfaces are given.

  14. Student and Instructor Perceptions of a Flipped College Algebra Classroom

    Science.gov (United States)

    Jaster, Robert W.

    2017-01-01

    Each year about half a million students fail to make planned academic progress due to college algebra, hence the need for researchers to find ways of improving the quality of instruction in the course. Recent research suggests that flipping college algebra to allow time for active learning in the classroom may improve student performance. Also,…

  15. How do medical students prepare for flipped classrooms?

    NARCIS (Netherlands)

    Bouwmeester, RAM; de Kleijn, R.A.M.; ten Cate, TJ; van Rijen, HVM; Westerveld, HE

    A flipped classroom, an approach abandoning traditional lectures and having students come together to apply acquired knowledge, requires students to come to class well prepared. The nature of this preparation is currently being debated. Watching web lectures as a preparation has typically been

  16. Flipped Top-Down is Systematic Bottom-Up

    NARCIS (Netherlands)

    Zaytsev, V.; Sturm, A.; Clark, T.

    2016-01-01

    The paper presents an experience report in course design for a versatile group of computer science students where their needs were surfaced and met by the combination of strict top-down exposure to course material and the flipped classroom model of lecturing.

  17. Applying a learning design methodology in the flipped classroom approach – empowering teachers to reflect

    DEFF Research Database (Denmark)

    Triantafyllou, Evangelia; Kofoed, Lise; Purwins, Hendrik

    2016-01-01

    One of the recent developments in teaching that heavily relies on current technology is the “flipped classroom” approach. In a flipped classroom the traditional lecture and homework sessions are inverted. Students are provided with online material in order to gain necessary knowledge before class...... through flipped classroom designs. In order to discuss the opportunities arising by this approach, the different components of the Learning Design – Conceptual Map (LD-CM) are presented and examined in the context of the flipped classroom. It is shown that viewing the flipped classroom through the lens......, tools and resources used in specific flipped classroom models, and it can make educators more aware of the decisions that have to be taken and people who have to be involved when designing a flipped classroom. By using the LD-CM, this paper also draws attention to the importance of characteristics...

  18. The Ins and Outs of Lipid Flip-Flop.

    Science.gov (United States)

    Allhusen, John S; Conboy, John C

    2017-01-17

    Our current view of cellular membranes centers on the fluid-mosaic model, which envisions the cellular membrane as a "liquidlike" bilayer of lipids, cholesterol, and proteins that freely diffuse in two dimensions. In stark contrast, the exchange of materials between the leaflets of a bilayer was presumed to be prohibited by the large enthalpic barrier associated with translocating hydrophilic materials, such as a charged lipid headgroup, through the hydrophobic membrane core. This static picture with regard to lipid translocation (or "flip-flop" as it is affectionately known) has been a long-held belief in the study of membrane dynamics. The current accepted membrane model invokes specific protein flippase (inward moving), floppase (outward moving), and scramblase (bidirectional) enzymes that assist in the movement of lipids between the leaflets of cellular membranes. The low rate of protein-free lipid flip-flop has also been a cornerstone of our understanding of the bilateral organization of cellular membrane components, specifically the asymmetric distribution of lipid species found in the luminal and extracellular leaflets of the plasma membrane of eukaryotic cells. Much of the previous work contributing to our current understanding of lipid flip-flop has utilized fluorescent- or spin-labeled lipids. However, there is growing evidence that these lipid probes do not accurately convey the dynamics and thermodynamics of native (unlabeled) lipid motion. This Account summarizes our research efforts directed toward developing a deep physical and chemical understanding of protein-free lipid flip-flop in phospholipid membrane models using sum-frequency vibrational spectroscopy (SFVS). Our use of SFVS enables the direct measurement of native lipid flip-flop in model membranes. In particular, we have explored the kinetic rates and activation thermodynamics of lipid translocation as a means of deciphering the underlying chemical and physical directors governing this

  19. Polarizing a stored proton beam by spin-flip?

    Energy Technology Data Exchange (ETDEWEB)

    Oellers, Dieter Gerd Christian

    2010-04-15

    The present thesis discusses the extraction of the electron-proton spin-flip cross-section. The experimental setup, the data analysis and the results are pictured in detail. The proton is described by a QCD-based parton model. In leading twist three functions are needed. The quark distribution, the helicity distribution and the transversity distribution. While the first two are well-known, the transversity distribution is largely unknown. A self-sufficient measurement of the transversity is possible in double polarized proton-antiproton scattering. This rises the need of a polarized antiproton beam. So far spin filtering is the only tested method to produce a polarized proton beam, which may be capable to hold also for antiprotons. In-situ polarization build-up of a stored beam either by selective removal or by spin-flip of a spin-(1)/(2) beam is mathematically described. A high spin-flip cross-section would create an effective method to produce a polarized antiproton beam by polarized positrons. Prompted by conflicting calculations, a measurement of the spin-flip cross-section in low-energy electron-proton scattering was carried out. This experiment uses the electron beam of the electron cooler at COSY as an electron target. The depolarization of the stored proton beam is detected. An overview of the experiment is followed by detailed descriptions of the cycle setup, of the electron target and the ANKE silicon tracking telescopes acting as a beam polarimeter. Elastic protondeuteron scattering is the analyzing reaction. The event selection is depicted and the beam polarization is calculated. Upper limits of the two electron-proton spin-flip cross-sections {sigma} {sub parallel} and {sigma} {sub perpendicular} {sub to} are deduced using the likelihood method. (orig.)

  20. Flipping the Learning: An Investigation into the Use of the Flipped Classroom Model in an Introductory Teaching Course

    Science.gov (United States)

    Vaughan, Michelle

    2014-01-01

    With a classroom full of millennial learners, it is essential that teacher educators adjust their pedagogy to meet their students' needs. This study explores the use of a flipped classroom model to engage preservice teachers in an Introduction to the Teaching Profession course. In addition, it explores the need for teacher education…

  1. Element nodes of sports equipment double back flip factions and double back flip hunched performed gymnast in floor exercise

    Directory of Open Access Journals (Sweden)

    Potop V.A.

    2014-04-01

    Full Text Available Purpose: to identify the node elements of sports equipment double back somersault tuck and double back flip bent. To compare the two types of nodes for double somersault. Material : the study involved eight gymnasts (age 12 - 14 years. All finalists in the competition floor exercise - reserve team Romania. The method of video - computer research and method of postural orientation movements. Results : identified nodal elements of sports equipment double back somersault tuck and double back flip bent. In the preparatory phase of motor actions - launcher body posture for reaching is repulsive to flip. In the phase of basic motor action - animation body postures (double back somersault tuck and bent (bent double back flip. Exercises are performed on the ascending and descending parts of the flight path of the demonstration of individual maximum lift height common center of mass. In the final phase of motor actions - final body posture - steady landing. Conclusions : indicators of key elements of sports equipment acrobatic exercises contain new scientific facts kinematic and dynamic structures of motor actions. They are necessary for the development of modern training programs acrobatic exercises in step specialized base preparation.

  2. Electromigration and thermomigration studies in composite high lead and eutectic tin-lead flip chip solder joint

    Science.gov (United States)

    Huang, Annie Tzuyu

    The effect of thermomigration and the combination effect of thermomigration and electromigration have been studied in composite SnPb flip chip solder joints. Because Al line on the silicon chip side is the major heat source exerted on flip chip solder joint, temperature gradient across the joint is induced when a long Al line is stressed with high current density. Under a estimated temperature gradient of 1000°C/cm, Sn-rich and Pb-rich phase separation is found to occur. Experimental results have shown that Sn-rich phase accumulates at the hot side and Pb-rich phase accumulates at the cold side after thermomigration. When solder bumps are current high current density, thermomigration was found to accompany electromigration. Not only Pb-rich phase migrated toward the anode side and Sn-rich phase migrated toward the cathode side due to electromigration, Sn-rich phase was found to migrate along the top of solder joint due to thermomigration. It was found that as void propagates along the top of the solder joint, current crowding region shifts with the tip of the void. This created a local hot spot and thus a lateral temperature gradient was induced for thermomigration to occur. To isolate the thermal effect from the current effect, ac stressing at 60 Hz was also utilized. Interestingly, ac seems to have an effect other than thermal effect due to the difference in microstructure evolution between pure thermomigration and ac case after stressing. Further investigation at different frequency is needed to fully understand the effect of ac. Furthermore, analysis was performed to explain the phenomena of phase separation and phase reversal in the solder joint considering a constraint volume within underfill. Both Kirkendall effect and back stress were considered. Finally, detail morphological change after thermomigration and electromigration were investigated. Grain refinement was found to occur at a certain stressing condition. Production of entropy and morphological

  3. Flipped versions of the universal 3-3-1 and the left-right symmetric models in [S U (3 )]3 : A comprehensive approach

    Science.gov (United States)

    Rodríguez, Oscar; Benavides, Richard H.; Ponce, William A.; Rojas, Eduardo

    2017-01-01

    By considering the 3-3-1 and the left-right symmetric models as low-energy effective theories of the S U (3 )C⊗S U (3 )L⊗S U (3 )R (for short [S U (3 )]3 ) gauge group, alternative versions of these models are found. The new neutral gauge bosons of the universal 3-3-1 model and its flipped versions are presented; also, the left-right symmetric model and its flipped variants are studied. Our analysis shows that there are two flipped versions of the universal 3-3-1 model, with the particularity that both of them have the same weak charges. For the left-right symmetric model, we also found two flipped versions; one of them is new in the literature and, unlike those of the 3-3-1, requires a dedicated study of its electroweak properties. For all the models analyzed, the couplings of the Z' bosons to the standard model fermions are reported. The explicit form of the null space of the vector boson mass matrix for an arbitrary Higgs tensor and gauge group is also presented. In the general framework of the [S U (3 )]3 gauge group, and by using the LHC experimental results and EW precision data, limits on the Z' mass and the mixing angle between Z and the new gauge bosons Z' are obtained. The general results call for very small mixing angles in the range 1 0-3 radians and MZ'>2.5 TeV .

  4. Contact Angle Goniometer

    Data.gov (United States)

    Federal Laboratory Consortium — Description:The FTA32 goniometer provides video-based contact angle and surface tension measurement. Contact angles are measured by fitting a mathematical expression...

  5. Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Safa, Ahmad R., E-mail: asafa@iupui.edu [Department of Pharmacology and Toxicology, Indiana University School of Medicine, 980 W. Walnut Street, R3-C524, Indianapolis, IN 46202 (United States); Indiana University Simon Cancer Center, Indiana University School of Medicine, 980 W. Walnut Street, R3-C524, Indianapolis, IN 46202 (United States); Pollok, Karen E. [Department of Pharmacology and Toxicology, Indiana University School of Medicine, 980 W. Walnut Street, R3-C524, Indianapolis, IN 46202 (United States); Indiana University Simon Cancer Center, Indiana University School of Medicine, 980 W. Walnut Street, R3-C524, Indianapolis, IN 46202 (United States); Herman B. Wells Center for Pediatric Research, 980 W. Walnut Street, R3-C524, Indianapolis, IN 46202 (United States)

    2011-03-29

    Cellular FLICE (FADD-like IL-1beta-converting enzyme)-inhibitory protein (c-FLIP) is a major resistance factor and critical anti-apoptotic regulator that inhibits tumor necrosis factor-alpha (TNF-alpha), Fas-L, and TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis as well as chemotherapy-triggered apoptosis in malignant cells. c-FLIP is expressed as long (c-FLIP{sub L}), short (c-FLIP{sub S}), and c-FLIP{sub R} splice variants in human cells. c-FLIP binds to FADD and/or caspase-8 or -10 in a ligand-dependent and-independent fashion, which in turn prevents death-inducing signaling complex (DISC) formation and subsequent activation of the caspase cascade. Moreover, c-FLIP{sub L} and c-FLIP{sub S} are known to have multifunctional roles in various signaling pathways, as well as activating and/or upregulating several cytoprotective signaling molecules. Upregulation of c-FLIP has been found in various tumor types, and its downregulation has been shown to restore apoptosis triggered by cytokines and various chemotherapeutic agents. Hence, c-FLIP is an important target for cancer therapy. For example, small interfering RNAs (siRNAs) that specifically knockdown the expression of c-FLIP{sub L} in diverse human cancer cell lines augmented TRAIL-induced DISC recruitment and increased the efficacy of chemotherapeutic agents, thereby enhancing effector caspase stimulation and apoptosis. Moreover, small molecules causing degradation of c-FLIP as well as decreasing mRNA and protein levels of c-FLIP{sub L} and c-FLIP{sub S} splice variants have been found, and efforts are underway to develop other c-FLIP-targeted cancer therapies. This review focuses on (1) the functional role of c-FLIP splice variants in preventing apoptosis and inducing cytokine and drug resistance; (2) the molecular mechanisms that regulate c-FLIP expression; and (3) strategies to inhibit c-FLIP expression and function.

  6. A novel role of c-FLIP protein in regulation of ER stress response.

    Science.gov (United States)

    Conti, Silvia; Petrungaro, Simonetta; Marini, Elettra Sara; Masciarelli, Silvia; Tomaipitinca, Luana; Filippini, Antonio; Giampietri, Claudia; Ziparo, Elio

    2016-09-01

    Cellular-Flice-like inhibitory protein (c-FLIP) is an apoptosis modulator known to inhibit the extrinsic apoptotic pathway thus blocking Caspase-8 processing in the Death Inducing Signalling Complex (DISC). We previously demonstrated that c-FLIP localizes at the endoplasmic reticulum (ER) and that c-FLIP-deficient mouse embryonic fibroblasts (MEFs) display an enlarged ER morphology. In the present study, we have addressed the consequences of c-FLIP ablation in the ER stress response by investigating the effects of pharmacologically-induced ER stress in Wild Type (WT) and c-FLIP-/- MEFs. Surprisingly, c-FLIP-/- MEFs were found to be strikingly more resistant than WT MEFs to ER stress-mediated apoptosis. Analysis of Unfolded Protein Response (UPR) pathways revealed that Pancreatic ER Kinase (PERK) and Inositol-Requiring Enzyme 1 (IRE1) branch signalling is compromised in c-FLIP-/- cells when compared with WT cells. We found that c-FLIP modulates the PERK pathway by interfering with the activity of the serine threonine kinase AKT. Indeed, c-FLIP-/- MEFs display higher levels of active AKT than WT MEFs upon ER stress, while treatment with a specific AKT inhibitor of c-FLIP-/- MEFs subjected to ER stress restores the PERK but not the IRE1 pathway. Importantly, the AKT inhibitor or dominant negative AKT transfection sensitizes c-FLIP-/- cells to ER stress-induced cell death while the expression of a constitutively active AKT reduces WT cells sensitivity to ER stress-induced death. Thus, our results demonstrate that c-FLIP modulation of AKT activity is crucial in controlling PERK signalling and sensitivity to ER stress, and highlight c-FLIP as a novel molecular player in PERK and IRE1-mediated ER stress response.

  7. Signal changes in gradient echo images of human brain induced by hypo- and hyperoxia

    DEFF Research Database (Denmark)

    Rostrup, Egill; Larsson, H B; Toft, P B

    1995-01-01

    degrees the values of delta R2* for cortical grey matter, central grey matter, white matter and the sagittal sinus were 0.79, 0.41, 0.26 and 3.00/s; with a flip angle of 10 degrees the corresponding values were 0.70, 0.37, 0.24 and 3.15/s. The total cerebral blood flow increased by 41% during inhalation...

  8. Information Literacy and the Flipped Classroom: Examining the Impact of a One-Shot Flipped Class on Student Learning and Perceptions

    Science.gov (United States)

    Brooks, Andrea Wilcox

    2014-01-01

    This article examines the flipped classroom approach in higher education and its use in one -shot information literacy instruction sessions. The author presents findings from a pilot study of student learning and student perceptions pertaining to flipped model IL instruction. Students from two sections of the same course participated in this…

  9. Information Literacy and the Flipped Classroom: Examining the Impact of a One-Shot Flipped Class on Student Learning and Perceptions

    Directory of Open Access Journals (Sweden)

    Andrea Wilcox Brooks

    2014-12-01

    Full Text Available This article examines the flipped classroom approach in higher education and its use in one-shot information literacy instruction sessions. The author presents findings from a pilot study of student learning and student perceptions pertaining to flipped model IL instruction. Students from two sections of the same course participated in this study. One section received one-shot information literacy instruction using a flipped approach, while the other section received traditional one-shot instruction. No difference was found between the two groups on a pre- and post-test analysis; however, an analysis of students’ final papers from the flipped section showed more bibliography citations to scholarly journal articles. In addition, a survey was conducted showing the majority of students preferred the flipped approach.

  10. Systematically Asymmetric Heliospheric Magnetic Field: Evidence for a Quadrupole Mode and Non-Axisymmetry with Polarity Flip-Flops

    Science.gov (United States)

    Mursula, K.; Hiltula, T.

    2004-10-01

    Recent studies of the heliospheric magnetic field (HMF) have detected interesting, systematic hemispherical and longitudinal asymmetries which have a profound significance for the understanding of solar magnetic fields. The in situ HMF measurements since the 1960s show that the heliospheric current sheet (HCS) is systematically shifted (coned) southward during solar minimum times, leading to the concept of a bashful ballerina. While temporary shifts can be considerably larger, the average HCS shift (coning) angle is a few degrees, less than the 7.2∘ tilt of the solar rotation axis. Recent solar observations during the last two solar cycles verify these results and show that the magnetic areas in the northern solar hemisphere are larger and their intensity weaker than in the south during long intervals in the late declining to minimum phase. The multipole expansion reveals a strong quadrupole term which is oppositely directed to the dipole term. These results imply that the Sun has a symmetric quadrupole S0 dynamo mode that oscillates in phase with the dominant dipole A0 mode. Moreover, the heliospheric magnetic field has a strong tendency to produce solar tilts that are roughly opposite in longitudinal phase. This implies is a systematic longitudinal asymmetry and leads to a “flip-flop” type behaviour in the dominant HMF sector whose period is about 3.2 years. This agrees very well with the similar flip-flop period found recently in sunspots, as well as with the observed ratio of three between the activity cycle period and the flip-flop period of sun-like stars. Accordingly, these results require that the solar dynamo includes three modes, A0, S0 and a non-axisymmetric mode. Obviously, these results have a great impact on solar modelling.

  11. Flipping the classroom to teach population health: Increasing the relevance.

    Science.gov (United States)

    Simpson, Vicki; Richards, Elizabeth

    2015-05-01

    In recent years, there have been multiple calls to enhance the population health and health promotion aspects of nursing programs. Further impetus has been provided by passage of the Affordable Care Act in 2010 with its focus on prevention. The need to develop students who can critically think and apply knowledge learned is crucial to the development of nurses who can integrate and apply the concepts of population-focused practice in society and a healthcare system undergoing transformation. This coupled with the ever changing needs of learners requires a different approach to content delivery and presentation. Flipped classroom courses, with an online component, offer the flexibility and technology desired by current undergraduate students. The use of a flipped classroom approach to re-design a population health course in a Midwestern nursing program resulted in stronger course evaluations from students and reflected better student understanding of the relevance of such content in a nursing curriculum.

  12. Pharmacists correcting schedule II prescriptions: DEA flip-flops continue.

    Science.gov (United States)

    Abood, Richard R

    2010-12-01

    The Drug Enforcement Administration (DEA) has in recent years engaged in flip-flopping over important policy decisions. The most recent example involved whether a pharmacist can correct a written schedule II prescription upon verification with the prescriber. For several years the DEA's policy permitted this practice. Then the DEA issued a conflicting policy statement in 2007 in the preamble to the multiple schedule II prescription regulation, causing a series of subsequent contradictory statements ending with the policy that pharmacists should follow state law or policy until the Agency issues a regulation. It is doubtful that the DEA's opinion in the preamble would in itself constitute legal authority, or that the Agency would try to enforce the opinion. Nonetheless, these flip-flop opinions have confused pharmacists, caused some pharmacies to have claims rejected by third party payors, and most likely have inconvenienced patients.

  13. The ideal flip-through impact: experimental and numerical investigation

    DEFF Research Database (Denmark)

    Bredmose, Henrik; Hunt-Raby, A.; Jayaratne, R.

    2010-01-01

    , with the focus location adjusted to produce a near-breaking wave impact with no discernible air entrainment or entrapment. Details of the resultant impact are presented in the form of high-speed video, pressure transducer and wave gauge records. Numerical reproduction of the wave transformation and impact...... is achieved by application of a linear wave-analysis model and a fully nonlinear potential-flow solver. Although more advanced models exist, use of the latter model type is interesting as (1) it was applied by Cooker and Peregrine (Proceedings of the 22nd International Conference on Coastal Engineering, 164......-176, 1990) in their original numerical discovery of the flip-through impact and (2) the assumptions behind the potential-flow model remain reasonably valid, until the flip-through jet begins to break into droplets. In the present study, the potential-flow model has been extended with the Schwarz...

  14. Comments on Flipped SU(5) (and F-theory)

    CERN Document Server

    Kuflik, Eric

    2010-01-01

    We study the impact of nonrenormalizable operators in flipped SU(5) that can generate a large mu term, R-parity violation, and rapid proton decay. While our motivation is to determine whether F-theory can naturally realize flipped SU(5), this analysis is general and leads to a characterization of symmetries capable of controlling such operators and should be independent of F-theory. We then discuss some specific implications for F-theory model building, where a significant mu problem is unavoidable. Finally, we mention previously noted difficulties associated to engineering GUT-Higgs fields in F-theory, suggest a direct engineering of SU(5) \\times U(1)_{\\chi} as an alternative, and present a sample construction of this type.

  15. Empowering Pre-Service Teachers to Produce Ubiquitous Flipped Classes

    Directory of Open Access Journals (Sweden)

    Soraya García-Sánchez

    2017-01-01

    Full Text Available This work focuses on technological and educational outcomes that resulted from the production of foreign language educational videos by 90 pre-service instructors enrolled in an official Master’s Degree in Secondary Education programme. This teaching practice, conducted during two consecutive years, was set in a ubiquitous learning environment with the intention of effectively linking digital technology with pedagogy by means of producing flipped classroom units. The findings reveal that these pre-service teachers successfully combined instructional dynamics with digital skills to produce flipped classes adapted to the young generation’s needs. The classroom becomes, therefore, a more participatory learner-centred scenario with a variety of interactive and collaborative activities performed by foreign language students.

  16. Nonlinear self-flipping of polarization states in asymmetric waveguides

    CERN Document Server

    Zhang, Wen Qi; Monro, Tanya M; Afshar, V Shahraam

    2012-01-01

    Waveguides of subwavelength dimensions with asymmetric geometries, such as rib waveguides, can display nonlinear polarization effects in which the nonlinear phase difference dominates the linear contribution, provided the birefringence is sufficiently small. We demonstrate that self-flipping polarization states can appear in such rib waveguides at low (mW) power levels. We describe an optical power limiting device with optimized rib waveguide parameters that can operate at low powers with switching properties.

  17. On Teacher's Teaching Behavior Based on the Flipped Classroom

    Institute of Scientific and Technical Information of China (English)

    Yang Haili; Huang Yumei

    2016-01-01

    Teacher’s teaching behavior refers to dominant behavior and invisible behaviors conducted by teachers during the process of teaching. The teaching process includes teaching preparation, lead-in, presentation and surveillance.Teacher’s teaching behavior has a vital effect on classroom teaching and students’ English learning. Therefore, the thesis analyzes and discusses the teacher’s behavior on the base of the flipped classroom and aims to make the teacher’s behavior have positive impact on students’ English learning.

  18. Surgical Outcome of Acetabular Fracture Using Trochanteric Flip Osteotomy

    Directory of Open Access Journals (Sweden)

    Espandar R

    2012-01-01

    Full Text Available Background: One of the difficulties in acetabulum surgery is appropriate exposure of the site of surgery. Trochanteric flip osteotomy is one of the surgical methods for superoposterior and posterior acetabulum exposure. However, due to possible complications some surgeons prefer to avoid this procedure. This study was undertaken to determine the outcome of surgical treatment of acetabular fracture using trochanteric flip osteotomy. Methods : In this prospective cohort study, 14 patients with acetabular fracture who had been admitted in Imam Khomeini Hospital in Tehran, Iran, during 2003-2006 underwent trochanteric flip osteotomy. The patients were followed for at least one year post-surgically. Demographics, radiologic findings, intensity of pain using visual analogue scale (VAS, Harris hip score (HHS, force of hip abductors and complications were noted. Data analysis was performed using SPSS ver. 13.Results : The mean HHS was 82.5 (55-95. Heterotopic ossification was observed in three patients. There were no cases of postoperative infection or nonunion. Only two patients showed displacement of osteotomized fragments. Reduction was anatomic in 10 patients. In one patient, the force of hip abductors was three-fifth. The mean hip pain was 3.4 based on VAS. There were no cases of femoral head osteonecrosis. With respect to HHS, the final hip status was excellent and good in four and six patients, respectively. Three patients had fair and only one patient had poor condition.Conclusion: It seems that trochanteric flip osteotomy has much fewer complications in comparison to other methods justifying its use in such cases.

  19. Spin flips and quantum information for anti-parallel spins

    CERN Document Server

    Gisin, Nicolas

    1999-01-01

    We consider two different ways to encode quantum information, by parallel or anti-parallel pairs of spins. We find that there is more information in the anti-parallel ones. This purely quantum mechanical effect is due to entanglement, not of the states but occuring in the course of the measuring process. We also introduce a range of quantum information processing machines, such as spin-flip and anti-cloning.

  20. Nonparaxial propagation of phase-flipped Gaussian beams

    Institute of Scientific and Technical Information of China (English)

    Gao Zeng-Hui; Lü Bai-Da

    2008-01-01

    This paper derives the closed-form expressions for nonparaxial phase flipped Gaussian (PFG) beams propagating in free space, through a knife edge and an aperture, which enable us to study nonparaxial propagation properties of PFG beams and to compare nonparaxial results with paraxial ones. It is found that the f parameter, offsetting distance of the knife edge and truncation parameter affect the nonparaxial beam propagation properties. Only under certain conditions the paraxial approximation is applicable. The results are illustrated by numerical examples.

  1. The worldline approach to helicity flip in plane waves

    CERN Document Server

    Ilderton, Anton

    2016-01-01

    We apply worldline methods to the study of vacuum polarisation effects in plane wave backgrounds, in both scalar and spinor QED. We calculate helicity-flip probabilities to one loop order and treated exactly in the background field, and provide a toolkit of methods for use in investigations of higher-order processes. We also discuss the connections between the worldline, S-matrix, and lightfront approaches to vacuum polarisation effects.

  2. A New Pixels Flipping Method for Huge Watermarking Capacity of the Invoice Font Image

    Directory of Open Access Journals (Sweden)

    Li Li

    2014-01-01

    Full Text Available Invoice printing just has two-color printing, so invoice font image can be seen as binary image. To embed watermarks into invoice image, the pixels need to be flipped. The more huge the watermark is, the more the pixels need to be flipped. We proposed a new pixels flipping method in invoice image for huge watermarking capacity. The pixels flipping method includes one novel interpolation method for binary image, one flippable pixels evaluation mechanism, and one denoising method based on gravity center and chaos degree. The proposed interpolation method ensures that the invoice image keeps features well after scaling. The flippable pixels evaluation mechanism ensures that the pixels keep better connectivity and smoothness and the pattern has highest structural similarity after flipping. The proposed denoising method makes invoice font image smoother and fiter for human vision. Experiments show that the proposed flipping method not only keeps the invoice font structure well but also improves watermarking capacity.

  3. Comparison of Pharmaceutical Calculations Learning Outcomes Achieved Within a Traditional Lecture or Flipped Classroom Andragogy.

    Science.gov (United States)

    Anderson, H Glenn; Frazier, Lisa; Anderson, Stephanie L; Stanton, Robert; Gillette, Chris; Broedel-Zaugg, Kim; Yingling, Kevin

    2017-05-01

    Objective. To compare learning outcomes achieved from a pharmaceutical calculations course taught in a traditional lecture (lecture model) and a flipped classroom (flipped model). Methods. Students were randomly assigned to the lecture model and the flipped model. Course instructors, content, assessments, and instructional time for both models were equivalent. Overall group performance and pass rates on a standardized assessment (Pcalc OSCE) were compared at six weeks and at six months post-course completion. Results. Student mean exam scores in the flipped model were higher than those in the lecture model at six weeks and six months later. Significantly more students passed the OSCE the first time in the flipped model at six weeks; however, this effect was not maintained at six months. Conclusion. Within a 6 week course of study, use of a flipped classroom improves student pharmacy calculation skill achievement relative to a traditional lecture andragogy. Further study is needed to determine if the effect is maintained over time.

  4. Spin flipping a stored vertically polarized proton beam with an RF solenoid

    Science.gov (United States)

    Phelps, R. A.; Blinov, B. B.; Chu, C. M.; Courant, E. D.; Crandell, D. A.; Kaufman, W. A.; Krisch, A. D.; Nurushev, T. S.; Ratner, L. G.; Wong, V. K.; Caussyn, D. D.; Derbenev, Ya. S.; Ellison, T. J. P.; Lee, S. Y.; Rinckel, T.; Schwandt, P.; Sperisen, F.; Stephenson, E. J.; Przewoski, B. von; Ohmori, C.

    1995-09-01

    A recent experiment in the IUCF cooler ring studied the spin flip of a stored vertically polarized 139 MeV proton beam. This spin flip was accomplished by using an RF solenoid to induce an artificial depolarizing resonance in the ring, and then varying the solenoid's frequency through this resonance value to induce spin flip. We found a polarization loss after multiple spin flips of about 0.00±0.05% per flip and also losses for very long flip times. This device will be useful for reducing systematic errors in polarized beam-internal target scattering asymmetry experiments by enabling experimenters to perform frequent beam polarization reversals in the course of the experiment.

  5. A new pixels flipping method for huge watermarking capacity of the invoice font image.

    Science.gov (United States)

    Li, Li; Hou, Qingzheng; Lu, Jianfeng; Xu, Qishuai; Dai, Junping; Mao, Xiaoyang; Chang, Chin-Chen

    2014-01-01

    Invoice printing just has two-color printing, so invoice font image can be seen as binary image. To embed watermarks into invoice image, the pixels need to be flipped. The more huge the watermark is, the more the pixels need to be flipped. We proposed a new pixels flipping method in invoice image for huge watermarking capacity. The pixels flipping method includes one novel interpolation method for binary image, one flippable pixels evaluation mechanism, and one denoising method based on gravity center and chaos degree. The proposed interpolation method ensures that the invoice image keeps features well after scaling. The flippable pixels evaluation mechanism ensures that the pixels keep better connectivity and smoothness and the pattern has highest structural similarity after flipping. The proposed denoising method makes invoice font image smoother and fiter for human vision. Experiments show that the proposed flipping method not only keeps the invoice font structure well but also improves watermarking capacity.

  6. Dancing droplets: Contact angle, drag, and confinement

    Science.gov (United States)

    Benusiglio, Adrien; Cira, Nate; Prakash, Manu

    2015-11-01

    When deposited on a clean glass slide, a mixture of water and propylene glycol forms a droplet of given contact angle, when both pure liquids spread. (Cira, Benusiglio, Prakash: Nature, 2015). The droplet is stabilized by a gradient of surface tension due to evaporation that induces a Marangoni flow from the border to the apex of the droplets. The apparent contact angle of the droplets depends on both their composition and the external humidity as captured by simple models. These droplets present remarkable properties such as lack of a large pinning force. We discuss the drag on these droplets as a function of various parameters. We show theoretical and experimental results of how various confinement geometries change the vapor gradient and the dynamics of droplet attraction.

  7. Seamless integration of CMOS and microfluidics using flip chip bonding

    Science.gov (United States)

    Welch, David; Blain Christen, Jennifer

    2013-03-01

    We demonstrate the microassembly of PDMS (polydimethylsiloxane) microfluidics with integrated circuits made in complementary metal-oxide-semiconductor (CMOS) processes. CMOS-sized chips are flip chip bonded to a flexible polyimide printed circuit board (PCB) with commercially available solder paste patterned using a SU-8 epoxy. The average resistance of each flip chip bond is negligible and all connections are electrically isolated. PDMS is attached to the flexible polyimide PCB using a combination of oxygen plasma treatment and chemical bonding with 3-aminopropyltriethoxysilane. The total device has a burst pressure of 175 kPA which is limited by the strength of the flip chip attachment. This technique allows the sensor area of the die to act as the bottom of the microfluidic channel. The SU-8 provides a barrier between the pad ring (electrical interface) and the fluids; post-processing is not required on the CMOS die. This assembly method shows great promise for developing analytic systems which combine the strengths of microelectronics and microfluidics into one device.

  8. Curriculum Design of a Flipped Classroom to Enhance Haematology Learning

    Science.gov (United States)

    Porcaro, Pauline A.; Jackson, Denise E.; McLaughlin, Patricia M.; O'Malley, Cindy J.

    2016-06-01

    A common trend in higher education is the "flipped" classroom, which facilitates active learning during class. The flipped approach to teaching was instituted in a haematology `major' class and the students' attitudes and preferences for the teaching materials were surveyed. The curriculum design was explicit and involved four major components (1) the preparation of the students; (2) the weekly pre-class work; (3) the in-class active learning strategies and (4) closing the learning loop using formative quizzes. Each of these components is discussed in detail and was informed by sound pedagogical strategies. Several different sources of information and several freely available software tools to engage the students are discussed. Two iterations are reported here, with improved pass rate for the final examination from 47 to 48 % in the traditional class to 56-65 % in the flipped classroom approach. The majority of students (93 and 89 %) came to the class prepared, after viewing the screencasts and engaged fully with the activities within the face-to-face time. The students perceived that solving case studies (93 %) was the most beneficial activity for their learning and this was closely followed by the production of essay plans (71 %). The majority of students recommended that this approach be repeated the following year (69 and 75 %).

  9. Classification of flipped SU(5) heterotic-string vacua

    Science.gov (United States)

    Faraggi, Alon E.; Rizos, John; Sonmez, Hasan

    2014-09-01

    We extend the classification of free fermionic heterotic-string vacua to models in which the SO(10) GUT symmetry is reduced at the string level to the flipped SU(5) subgroup. In our classification method the set of boundary condition basis vectors is fixed and the enumeration of string vacua is obtained in terms of the Generalised GSO (GGSO) projection coefficients entering the one-loop partition function. We derive algebraic expressions for the GGSO projections for all the physical states appearing in the sectors generated by the set of basis vectors. This enables the programming of the entire spectrum analysis in a computer code. For that purpose we developed two independent codes, based on FORTRAN95 and JAVA, and all results presented are confirmed by the two independent routines. We perform a statistical sampling in the space of 244∼1013 flipped SU(5) vacua, and scan up to 1012 GGSO configurations. Contrary to the corresponding Pati-Salam classification results, we do not find exophobic flipped SU(5) vacua with an odd number of generations. We study the structure of exotic states appearing in the three generation models, that additionally contain a viable Higgs spectrum, and demonstrate the existence of models in which all the exotic states are confined by a hidden sector non-Abelian gauge symmetry, as well as models that may admit the racetrack mechanism.

  10. "Flipping" educational technology professional development for K-12 educators

    Science.gov (United States)

    Spencer, Daniel

    As the demand for more effective professional development increases in K-12 schools, trainers must adjust their training methods to meet the needs of their teacher learners. Just as lecture-heavy, teacher-centered instruction only meet the learning needs of a small minority of students, "sit and get" professional development rarely results in the teachers gaining the skills and confidence necessary to use technology effectively in their instruction. To resolve the frustrations of teachers related to ineffective professional development, a "Flipped PD" training model was developed based on the learning needs of adult learners, the integration of technological, pedagogical, and content knowledge (TPACK), learning activities, and the Flipped Classroom concept. Under this model, training shifts from a passive, trainer-centered format, to an active, learner-centered format where teachers learn to use technology in their classrooms by first focusing on pedagogical issues, then choosing the options that work best for addressing those issues in their unique situation, and completing "learn-by-doing" projects. Those who participate in "Flipped PD" style trainings tend to have more confidence upon completion that they can use the tools they were trained on in their teaching, as well as believe that the PD was engaging and a good use of their time.

  11. Perforin rapidly induces plasma membrane phospholipid flip-flop.

    Directory of Open Access Journals (Sweden)

    Sunil S Metkar

    Full Text Available The cytotoxic cell granule secretory pathway is essential for host defense. This pathway is fundamentally a form of intracellular protein delivery where granule proteases (granzymes from cytotoxic lymphocytes are thought to diffuse through barrel stave pores generated in the plasma membrane of the target cell by the pore forming protein perforin (PFN and mediate apoptotic as well as additional biological effects. While recent electron microscopy and structural analyses indicate that recombinant PFN oligomerizes to form pores containing 20 monomers (20 nm when applied to liposomal membranes, these pores are not observed by propidium iodide uptake in target cells. Instead, concentrations of human PFN that encourage granzyme-mediated apoptosis are associated with pore structures that unexpectedly favor phosphatidylserine flip-flop measured by Annexin-V and Lactadherin. Efforts that reduce PFN mediated Ca influx in targets did not reduce Annexin-V reactivity. Antigen specific mouse CD8 cells initiate a similar rapid flip-flop in target cells. A lipid that augments plasma membrane curvature as well as cholesterol depletion in target cells enhance flip-flop. Annexin-V staining highly correlated with apoptosis after Granzyme B (GzmB treatment. We propose the structures that PFN oligomers form in the membrane bilayer may include arcs previously observed by electron microscopy and that these unusual structures represent an incomplete mixture of plasma membrane lipid and PFN oligomers that may act as a flexible gateway for GzmB to translocate across the bilayer to the cytosolic leaflet of target cells.

  12. Classification of flipped SU(5 heterotic-string vacua

    Directory of Open Access Journals (Sweden)

    Alon E. Faraggi

    2014-09-01

    Full Text Available We extend the classification of free fermionic heterotic-string vacua to models in which the SO(10 GUT symmetry is reduced at the string level to the flipped SU(5 subgroup. In our classification method the set of boundary condition basis vectors is fixed and the enumeration of string vacua is obtained in terms of the Generalised GSO (GGSO projection coefficients entering the one-loop partition function. We derive algebraic expressions for the GGSO projections for all the physical states appearing in the sectors generated by the set of basis vectors. This enables the programming of the entire spectrum analysis in a computer code. For that purpose we developed two independent codes, based on FORTRAN95 and JAVA, and all results presented are confirmed by the two independent routines. We perform a statistical sampling in the space of 244∼1013 flipped SU(5 vacua, and scan up to 1012 GGSO configurations. Contrary to the corresponding Pati–Salam classification results, we do not find exophobic flipped SU(5 vacua with an odd number of generations. We study the structure of exotic states appearing in the three generation models, that additionally contain a viable Higgs spectrum, and demonstrate the existence of models in which all the exotic states are confined by a hidden sector non-Abelian gauge symmetry, as well as models that may admit the racetrack mechanism.

  13. Classification of flipped SU(5) heterotic-string vacua

    Energy Technology Data Exchange (ETDEWEB)

    Faraggi, Alon E., E-mail: alon.faraggi@liv.ac.uk [Department of Mathematical Sciences, University of Liverpool, Liverpool L69 7ZL (United Kingdom); Rizos, John, E-mail: irizos@uoi.gr [Department of Physics, University of Ioannina, GR45110 Ioannina (Greece); Sonmez, Hasan, E-mail: Hasan.Sonmez@liv.ac.uk [Department of Mathematical Sciences, University of Liverpool, Liverpool L69 7ZL (United Kingdom)

    2014-09-15

    We extend the classification of free fermionic heterotic-string vacua to models in which the SO(10) GUT symmetry is reduced at the string level to the flipped SU(5) subgroup. In our classification method the set of boundary condition basis vectors is fixed and the enumeration of string vacua is obtained in terms of the Generalised GSO (GGSO) projection coefficients entering the one-loop partition function. We derive algebraic expressions for the GGSO projections for all the physical states appearing in the sectors generated by the set of basis vectors. This enables the programming of the entire spectrum analysis in a computer code. For that purpose we developed two independent codes, based on FORTRAN95 and JAVA, and all results presented are confirmed by the two independent routines. We perform a statistical sampling in the space of 2{sup 44}∼10{sup 13} flipped SU(5) vacua, and scan up to 10{sup 12} GGSO configurations. Contrary to the corresponding Pati–Salam classification results, we do not find exophobic flipped SU(5) vacua with an odd number of generations. We study the structure of exotic states appearing in the three generation models, that additionally contain a viable Higgs spectrum, and demonstrate the existence of models in which all the exotic states are confined by a hidden sector non-Abelian gauge symmetry, as well as models that may admit the racetrack mechanism.

  14. Base Flipping in Open Complex Formation at Bacterial Promoters

    Directory of Open Access Journals (Sweden)

    Mary E. Karpen

    2015-04-01

    Full Text Available In the process of transcription initiation, the bacterial RNA polymerase binds double-stranded (ds promoter DNA and subsequently effects strand separation of 12 to 14 base pairs (bp, including the start site of transcription, to form the so-called “open complex” (also referred to as RPo. This complex is competent to initiate RNA synthesis. Here we will review the role of σ70 and its homologs in the strand separation process, and evidence that strand separation is initiated at the −11A (the A of the non-template strand that is 11 bp upstream from the transcription start site of the promoter. By using the fluorescent adenine analog, 2-aminopurine, it was demonstrated that the −11A on the non-template strand flips out of the DNA helix and into a hydrophobic pocket where it stacks with tyrosine 430 of σ70. Open complexes are remarkably stable, even though in vivo, and under most experimental conditions in vitro, dsDNA is much more stable than its strand-separated form. Subsequent structural studies of other researchers have confirmed that in the open complex the −11A has flipped into a hydrophobic pocket of σ70. It was also revealed that RPo was stabilized by three additional bases of the non-template strand being flipped out of the helix and into hydrophobic pockets, further preventing re-annealing of the two complementary DNA strands.

  15. Digital Storytelling in a Flipped Classroom for Effective Learning

    Directory of Open Access Journals (Sweden)

    Clemens Bechter

    2017-06-01

    Full Text Available Conclusive empirical evidence on whether virtual classrooms result in higher performance, satisfaction, or an improvement in problem solving skills when compared with traditional face-to-face lecturing does not exist. Various studies point in different directions. However, blended learning outperforms the traditional classroom in student performance and satisfaction. A flipped classroom is one type of blended learning. For more than 20 years, this approach has been used at a European executive MBA (EMBA program delivering online content combined with six residential weeks where students collaborate and reflect upon their online learning. Our research examined the overall setup of this program, and assessed one course in depth. As part of the course—International Management—an intercultural negotiation project was chosen to highlight the integration of online and offline activities. The flipped classroom is a demonstration of the reform-based teaching approach. The power of reform-based learning in executive education is the engaging combination of practice and theory, which improves the performance of executives. The participants considered the flipped approach exciting, dynamic, and insightful. The emphasis on a negotiation process involving classmates from around the world increased their global understanding. Beginning with a negotiation experience in the digital story project gave them a better appreciation of the relevant theories, techniques, and applications. Focusing on the practice of international negotiation and a cross-cultural analysis with reflection on cultural intelligence improved the competencies of the participants both during the course and after it.

  16. Comparative analysis of learning gains and students attitudes in a flipped precalculus classroom

    OpenAIRE

    Voigt, Matthew

    2016-01-01

    International audience; Flipped classrooms are becoming increasingly prevalent at the undergraduate level as institutions seek cost-saving measures while also desiring to implement technological innovations to attract 21st century learners. This study examined undergraduate pre-calculus students' (N=427) experiences, attitudes and mathematical knowledge in a flipped classroom format compared to students in a traditional lecture format. Our initial results indicate students in the flipped form...

  17. Curvature Gradient Driving Droplets in Fast Motion

    CERN Document Server

    Lv, Cunjing; Yin, Yajun; Tseng, Fan-gang; Zheng, Quanshui

    2011-01-01

    Earlier works found out spontaneous directional motion of liquid droplets on hydrophilic conical surfaces, however, not hydrophobic case. Here we show that droplets on any surface may take place spontaneous directional motion without considering contact angle property. The driving force is found to be proportional to the curvature gradient of the surface. Fast motion can be lead at surfaces with small curvature radii. The above discovery can help to create more effective transportation technology of droplets, and better understand some observed natural phenomena.

  18. Nondestructive diagnosis of flip chips based on vibration analysis using PCA-RBF

    Science.gov (United States)

    Su, Lei; Shi, Tielin; Liu, Zhiping; Zhou, Hongdi; Du, Li; Liao, Guanglan

    2017-02-01

    Flip chip technology combined with solder bump interconnection has been widely applied in IC package. The solder bumps are sandwiched between dies and substrates, leading to conventional techniques being difficult to diagnose the flip chips. Meanwhile, these conventional diagnosis methods are usually performed by human visual judgment. The human eye-fatigue can easily cause fault detection. Thus, it is difficult and crucial to detect the defects of flip chips automatically. In this paper, a nondestructive diagnosis system based on vibration analysis is proposed. The flip chip is excited by air-coupled ultrasounds and raw vibration signals are measured by a laser scanning vibrometer. Forty-two features are extracted for analysis, including ten time domain features, sixteen frequency domain features and sixteen wavelet packet energy features. Principal component analysis is used for feature reduction. Radial basis function neural network is adopted for classification and recognition. Flip chips in three states (good flip chips, flip chips with missing solder bumps and flip chips with open solder bumps) are utilized to validate the proposed method. The results demonstrate that this method is effective for defect inspection in flip chip package.

  19. The Flipped Classroom Teaching Model and Its Use for Information Literacy Instruction

    Directory of Open Access Journals (Sweden)

    Sara Arnold-Garza

    2014-07-01

    Full Text Available The “flipped classroom” teaching model has emerged in a variety of educational settings. It provides many advantages for students and exploits the affordances of modern technology. This article describes some of the pedagogical and logistical characteristics of the flipped teaching model. It situates the flipped classroom in higher education and library instruction, and make the case that there are characteristics of information literacy instruction that fit well with the flipped teaching model, in addition to providing some unique challenges.

  20. EXPRESSION OF FLIP IN HUMAN COLON CARCINOMAS:A NEW MECHANISM OF IMMUNE EVASION

    Institute of Scientific and Technical Information of China (English)

    XING Bao-cai; S. Wimmenauer; EH. Farthmann

    2005-01-01

    Objective: It has been proposed that Fas ligand (FasL) may play an important role in immune escape of tumors and FLIP is an important mediator of Fas/FasL pathway. In this study, the expression of FLIP was determined in human colon carcinoma cell lines and tissue to investigate the new mechanism of immune evasion of human colon carcinomas. Methods:RT-PCR and immunohistochemistry (IHC) were performed to investigate the expression of FLIP in human colon carcinoma cell lines SW480, LS174 and twenty human primary colon carcinoma specimens. Results: It was shown that SW480 cells,LS174 cells and primary colon carcinoma specimen constitutively expressed FLIP at the mRNA and protein level. The expression of FLIP was not found in the epithelial cells of normal colon mucosa. Conclusion: FLIP was expressed in human primary colon carcinoma specimens but not in the normal counterpart. It suggested that the expression of FLIP may occur during the malignant transformation from normal colon epithelial cells to colon carcinoma cells. Tumor cells might obtain the ability to resist the Fas-mediated apoptosis by expressing FLIP. The expression of FLIP might contribute to the formation of colon carcinomas.

  1. Effect of transgenic overexpression of FLIP on lymphocytes on development and resolution of experimental autoimmune thyroiditis.

    Science.gov (United States)

    Fang, Yujiang; Sharp, Gordon C; Braley-Mullen, Helen

    2011-09-01

    In our previous studies, resolution of granulomatous experimental autoimmune thyroiditis (G-EAT) was promoted when thyroid epithelial cells were protected from Fas-mediated apoptosis due to transgenic overexpression of FLIP. We hypothesized that if FLIP were overexpressed on lymphocytes, CD4(+) effector cells would be protected from Fas-mediated apoptosis, and resolution would be delayed. To test this hypothesis, we generated transgenic (Tg) mice overexpressing FLIP under the CD2 promoter. Transgenic FLIP was expressed on CD4(+) and CD8(+) T cells and B cells. Transgenic overexpression of FLIP protected cultured splenocytes from Fas-mediated, but not irradiation-induced, apoptosis in vitro. Unexpectedly, Tg(+) donor cells transferred minimal G-EAT, which was partially overcome by depleting donor CD8(+) T cells. When Tg(+) and Tg(-) donors transferred equivalent disease, G-EAT resolution was delayed in FLIP transgenic mice. However, CD2-FLIP Tg(+) donors often transferred less severe G-EAT, even after depletion of CD8(+) T cells. This influenced the rate of G-EAT resolution, resulting in little difference in G-EAT resolution between groups. Tg(+) mice always had reduced anti-mouse thyroglobulin autoantibody responses, compared with Tg(-) littermates, presumably because of FLIP overexpression on B cells. These results suggest that effects of transgenic FLIP on a particular autoimmune disease vary, depending on what cells express the transgene and whether those cells are effector cells or if they function to modulate disease.

  2. Gradients are shaping up.

    Science.gov (United States)

    Bollenbach, Tobias; Heisenberg, Carl-Philipp

    2015-04-23

    In animal embryos, morphogen gradients determine tissue patterning and morphogenesis. Shyer et al. provide evidence that, during vertebrate gut formation, tissue folding generates graded activity of signals required for subsequent steps of gut growth and differentiation, thereby revealing an intriguing link between tissue morphogenesis and morphogen gradient formation.

  3. Fast Distributed Gradient Methods

    CERN Document Server

    Jakovetic, Dusan; Moura, Jose M F

    2011-01-01

    The paper proposes new fast distributed optimization gradient methods and proves convergence to the exact solution at rate O(\\log k/k), much faster than existing distributed optimization (sub)gradient methods with convergence O(1/\\sqrt{k}), while incurring practically no additional communication nor computation cost overhead per iteration. We achieve this for convex (with at least one strongly convex,) coercive, three times differentiable and with Lipschitz continuous first derivative (private) cost functions. Our work recovers for distributed optimization similar convergence rate gains obtained by centralized Nesterov gradient and fast iterative shrinkage-thresholding algorithm (FISTA) methods over ordinary centralized gradient methods. We also present a constant step size distributed fast gradient algorithm for composite non-differentiable costs. A simulation illustrates the effectiveness of our distributed methods.

  4. Preparation of gradient polyacrylate brushes in microchannels.

    Science.gov (United States)

    Lee, Seongyeol; Youm, Sang Gil; Song, Yeari; Yi, Whikum; Sohn, Daewon

    2012-05-01

    Gradient poly(2-hydroxyethyl methacrylate) brushes were synthesized by surface-initiated atom transfer radical polymerization (ATRP) confined within a microfluidic system on a silicon wafer. For ATRP, surface initiator, 11-((2-bromo, 2-methyl) propionyloxy) undecyltrichlorosilane (BUC), was synthesized, and allowed to self-assemble in a monolayer on the Si wafer, as analyzed by XPS to confirm the presence of an ester group of BUC. A solution containing 2-hydroxyethylmethacrylate, Cu catalyst, and bipyridin was allowed to flow in a microchannel and polymerize, resulting in the brushes with a gradient of thickness on the Si wafer. Using ellipsometry and ATR-IR, we verified the gradients of well established brushes on the Si wafer. AFM and contact angle data showed that wettability of the brushes did not exhibit a linear relationship with hydrophilicity.

  5. Liquid droplet movement on horizontal surface with gradient surface energy

    Institute of Scientific and Technical Information of China (English)

    LIAO Qiang; WANG Hong; ZHU Xun; LI Mingwei

    2006-01-01

    A surface with gradient surface energy was fabricated on a silicon wafer by using the chemical vapor deposition (CVD) technology with the dodecyltrichlorosilane (C12H25Cl3Si) vapor which was adsorbed chemically on the surface of the silicon wafer to form a self-assemble monolayer (ASM) and thus a gradient profile of wettability. The microscopic contours of the gradient surface were measured with Seiko SPA400 atom force microscope (AFM). And the surface wettability profile was characterized by the sessile drop method, measuring the contact angle of fine water droplets that lay on the gradient surface, to represent the distribution of the surface energy on the surface. Using a high-speed video imaging system, the motion of water droplet on the horizontal gradient surface was visualized and the transient velocity was measured under ambient condition. The experimental results show that the liquid droplets can be driven to move from hydrophobic side to hydrophilic side on the horizontal gradient surface and the velocity of droplet can reach up to 40 mm/s. In addition, the motion of the water droplet can be generally divided into two stages: an acceleration stage and a deceleration stage. The droplet presents a squirming movement on the surface with a lower peak velocity and a larger extent of deceleration motion. And the static advancing contact angle of the droplet is obviously larger than the dynamic advancing contact angle on the gradient energy surface.

  6. Dropwise Condensation on a Radial Gradient Surface

    Science.gov (United States)

    Macner, Ashley; Daniel, Susan; Steen, Paul

    2013-11-01

    In transient dropwise condensation from steam onto a cool surface, distributions of drops evolve by nucleation, growth, and coalescence. This study examines how surface functionalization affects drop growth and coalescence. Surfaces are treated by silanization to deliver either a spatially uniform contact-angle (hydrophilic, neutral, and hydrophobic) or a radial gradient of contact-angles. The time evolution of number-density and associated drop-size distributions are reported. For a typical condensation experiment on a uniform angle surface, the number-density curves show two regimes: an initial increase in number-density as a result of nucleation and a subsequent decrease in number-density as a result of larger scale coalescence events. Without a removal mechanism, the fractional coverage, regardless of treatment, approaches unity. For the same angle-surface, the associated drop-size distributions progress through four different shapes along the growth curve. In contrast, for a radial gradient surface where removal by sweeping occurs, the number-density increases and then levels off to a value close to the maximum number-density that is well below unity coverage and only two shapes of distributions are observed. Implications for heat transfer will be discussed. This work was supported by a NASA Office of the Chief Technologist's Space Technology Research Fellowship.

  7. Reading Angles in Maps

    Science.gov (United States)

    Izard, Véronique; O'Donnell, Evan; Spelke, Elizabeth S.

    2014-01-01

    Preschool children can navigate by simple geometric maps of the environment, but the nature of the geometric relations they use in map reading remains unclear. Here, children were tested specifically on their sensitivity to angle. Forty-eight children (age 47:15-53:30 months) were presented with fragments of geometric maps, in which angle sections…

  8. Gradient change in the acquisition of phonology.

    Science.gov (United States)

    Hewlett, Nigel; Waters, Daphne

    2004-01-01

    The prevailing view of phonological development is that changes in pronunciation are driven by phonological changes. This view (it is argued here) derives from the particular form of the data that has most often been used in studies of phonological development, namely broad phonetic transcriptions. Transcribing an earlier pronunciation with one phoneme symbol and a later pronunciation with a different symbol encourages the interpretation that the child has made a flip from one category to another. However, broad transcriptions may have misrepresented the facts of speech development. We review some auditory-based studies which have used a more fine-grained phonetic transcription and discuss the significance of findings on the development of long-lag plosives. We argue that gradient change is the typical fashion in which children's speech output development progresses; that it is therefore not appropriate to use rules of the sort that are employed for morphophonemic alternations in adult phonology to explain revisions over time in children's pronunciations; and that a child's speech output is not the best guide to their phonology.

  9. Second gradient poromechanics

    CERN Document Server

    Sciarra, Giulio; Coussy, Olivier

    2010-01-01

    Second gradient theories have been developed in mechanics for treating different phenomena as capillarity in fluids, plasticity and friction in granular materials or shear band deformations. Here, there is an attempt of formulating a second gradient Biot like model for porous materials. In particular the interest is focused in describing the local dilatant behaviour of a porous material induced by pore opening elastic and capillary interaction phenomena among neighbouring pores and related micro-filtration phenomena by means of a continuum microstructured model. The main idea is to extend the classical macroscopic Biot model by including in the description second gradient effects. This is done by assuming that the surface contribution to the external work rate functional depends on the normal derivative of the velocity or equivalently assuming that the strain work rate functional depends on the porosity and strain gradients. According to classical thermodynamics suitable restrictions for stresses and second g...

  10. Turning the Classroom Upside Down: Experimenting with the Flipped Classroom in American Government

    Science.gov (United States)

    Whitman Cobb, Wendy N.

    2016-01-01

    With the concept of the flipped classroom taking the teaching world by storm, research into its effectiveness, particularly in higher education, has been lacking. This research aims to rectify this by detailing the results of an experiment comparing student success in American Federal Government in a flipped classroom, a traditional, lecture-based…

  11. Content Planning and Delivery in a Flipped Classroom: A Qualitative Examination

    Science.gov (United States)

    Oyola, Michelle

    2016-01-01

    The problem this qualitative case study addressed is the lack of a clear model for flipping all content planning and delivery in elementary classrooms. The purpose of this study was to create a model of how to flip all aspects of content planning and delivery in an elementary classroom. A total of 11 teachers were recruited to participate. All…

  12. A Quantitative Evaluation of the Flipped Classroom in a Large Lecture Principles of Economics Course

    Science.gov (United States)

    Balaban, Rita A.; Gilleskie, Donna B.; Tran, Uyen

    2016-01-01

    This research provides evidence that the flipped classroom instructional format increases student final exam performance, relative to the traditional instructional format, in a large lecture principles of economics course. The authors find that the flipped classroom directly improves performance by 0.2 to 0.7 standardized deviations, depending on…

  13. Motivation and Cognitive Load in the Flipped Classroom: Definition, Rationale and a Call for Research

    Science.gov (United States)

    Abeysekera, Lakmal; Dawson, Phillip

    2015-01-01

    Flipped classroom approaches remove the traditional transmissive lecture and replace it with active in-class tasks and pre-/post-class work. Despite the popularity of these approaches in the media, Google search, and casual hallway chats, there is very little evidence of effectiveness or consistency in understanding what a flipped classroom…

  14. The Flipped Classroom and Cooperative Learning: Evidence from a Randomised Experiment

    Science.gov (United States)

    Foldnes, Njål

    2016-01-01

    This article describes a study which compares the effectiveness of the flipped classroom relative to the traditional lecture-based classroom. We investigated two implementations of the flipped classroom. The first implementation did not actively encourage cooperative learning, with students progressing through the course at their own pace. With…

  15. Biology Teacher's Flipped Classroom: "A Simple Thing, But It's so Powerful"

    Science.gov (United States)

    Pearson, George

    2012-01-01

    Carolyn Durley is a veteran Biology teacher who adopted the Flipped Classroom in the 2011-2012 school year, the same year as Graham Johnson adopted it for Math. They both teach in Okanagan Mission Secondary School in Kelowna , B.C. This paper offers Durley's observations regarding her adoption of Flipped Classroom. She narrates her teaching…

  16. Improvements from a Flipped Classroom May Simply Be the Fruits of Active Learning

    Science.gov (United States)

    Jensen, Jamie L.; Kummer, Tyler A.; Godoy, Patricia D. d. M.

    2015-01-01

    The "flipped classroom" is a learning model in which content attainment is shifted forward to outside of class, then followed by instructor-facilitated concept application activities in class. Current studies on the flipped model are limited. Our goal was to provide quantitative and controlled data about the effectiveness of this model.…

  17. Using Flipped Classroom Components in Blended Courses to Maximize Student Learning

    Science.gov (United States)

    Heinerichs, Scott; Pazzaglia, Gina; Gilboy, Mary Beth

    2016-01-01

    Context: The flipped classroom is an educational approach that has become popular in higher education because it is student centered. Objective: To provide a rationale for a specific way of approaching the flipped classroom using a blended course design and resources necessary to help instructors be successful. Main Outcome Measure(s): Three class…

  18. Comparative Case Study on Designing and Applying Flipped Classroom at Universities

    Science.gov (United States)

    Lim, Cheolil; Kim, Sunyoung; Lee, Jihyun; Kim, Hyeonsu; Han, Hyeongjong

    2014-01-01

    There have been many reports on cases where flipped classroom was applied which put greater emphasis on conducting various learning activities during class. However, there is a limitation in redesigning existing university lectures as flipped classrooms merely based on reports that describe the learning activities of and their effects on…

  19. Search Strategy Development in a Flipped Library Classroom: A Student-Focused Assessment

    Science.gov (United States)

    Goates, Michael C.; Nelson, Gregory M.; Frost, Megan

    2017-01-01

    Librarians at Brigham Young University compared search statement development between traditional lecture and flipped instruction sessions. Students in lecture sessions scored significantly higher on developing search statements than those in flipped sessions. However, student evaluations show a strong preference for pedagogies that incorporate…

  20. A Controlled Study of the Flipped Classroom with Numerical Methods for Engineers

    Science.gov (United States)

    Bishop, Jacob L.

    2013-01-01

    Recent advances in technology and ideology have unlocked entirely new directions for education research. Mounting pressure from increasing tuition costs and free, online course offerings are opening discussion and catalyzing change in the physical classroom. The flipped classroom is at the center of this discussion. The flipped classroom is a new…

  1. Implementing Flipped Classroom in Blended Learning Environments: A Proposal Based on the Cognitive Flexibility Theory

    Science.gov (United States)

    Andrade, Mariel; Coutinho, Clara

    2017-01-01

    Flipped Classroom is an issue that gains increased attention in Blended Learning models. Generally, in the traditional classroom, the teacher uses the time in the classroom to explain the theoretical and conceptual body content and leaves the practices and exercises as extracurricular activities. In the Flipped Classroom, students study at home…

  2. Flipped Classrooms: A Review of Key Ideas and Recommendations for Practice

    Science.gov (United States)

    DeLozier, Sarah J.; Rhodes, Matthew G.

    2017-01-01

    Flipped classrooms refer to the practice of assigning lectures outside of class and devoting class time to a variety of learning activities. In this review, we discuss the range of approaches to the flipped classroom and focus on activities frequently used in these settings. Amongst these, we examine both out-of-class activities (e.g., video…

  3. Academic Achievements and Satisfaction of the Clicker-Aided Flipped Business English Writing Class

    Science.gov (United States)

    Zhonggen, Yu; Guifang, Wang

    2016-01-01

    The flipped classroom has been achieving a great success in teaching innovation. This study, aiming to determine the effectiveness of the flipped model in business English writing course, combined the quantitative with the qualitative research methods. Participants were randomly selected from undergraduate students majoring in business English.…

  4. Flipping a Math Content Course for Pre-Service Elementary School Teachers

    Science.gov (United States)

    Ford, Pari

    2015-01-01

    In this paper I will share my experience with flipping a math content course for pre-service elementary teachers. The flipped class format involves students receiving instruction outside the classroom through readings and/or video lectures and working on "homework" inside the classroom. I will share strategies for creating lessons for my…

  5. The Flipped Classroom Teaching Model and Its Use for Information Literacy Instruction

    Science.gov (United States)

    Arnold-Garza, Sara

    2014-01-01

    The flipped classroom, a teaching method that delivers lecture content to students at home through electronic means and uses class time for practical application activities, may be useful for information literacy instruction. This article describes many of the characteristics of the flipped classroom teaching model, illustrated with examples from…

  6. Flipping the Classroom for English Language Learners to Foster Active Learning

    Science.gov (United States)

    Hung, Hsiu-Ting

    2015-01-01

    This paper describes a structured attempt to integrate flip teaching into language classrooms using a WebQuest active learning strategy. The purpose of this study is to examine the possible impacts of flipping the classroom on English language learners' academic performance, learning attitudes, and participation levels. Adopting a…

  7. Coordinated Implementation and Evaluation of Flipped Classes and Peer-Led Team Learning in General Chemistry

    Science.gov (United States)

    Robert, Jenay; Lewis, Scott E.; Oueini, Razanne; Mapugay, Andrea

    2016-01-01

    The research-based pedagogical strategy of flipped classes has been shown to be effective for increasing student achievement and retention in postsecondary chemistry classes. The purpose of flipped classes is to move content delivery (e.g., lecture) outside of the classroom, freeing more face-to-face time for active learning strategies. The…

  8. Flipping the Composing Process: Collaborative Drafting and Résumé Writing

    Science.gov (United States)

    Anders, Abram

    2016-01-01

    This article argues for a flipped learning approach to business and professional communication composing processes. Flipped learning sequences can scaffold more robust engagement with prewriting activities and support opportunities for in-class collaborative and facilitated drafting exercises. These types of learning experiences offer numerous…

  9. The Flipped Classroom Impact in Grammar Class on EFL Saudi Secondary School Students' Performances and Attitudes

    Science.gov (United States)

    Al-Harbi, Sarah S.; Alshumaimeri, Yousif A.

    2016-01-01

    The aim of this study was to apply the flipped classroom strategy in teaching English grammar to examine its impact on secondary school students' performances, perceptions, and attitudes toward learning English independently. The researcher implemented the flipped classroom strategy by selecting videos based on the students' textbook and uploading…

  10. Flipped Classrooms: An Agenda for Innovative Marketing Education in the Digital Era

    Science.gov (United States)

    Green, Teegan

    2015-01-01

    Flipped classrooms reverse traditional lecturing because students learn content before class through readings and prerecorded videos, freeing lectures for hands-on activities and discussion. However, there is a dearth of literature in marketing education addressing flipped classrooms. This article fills this void using grounded theory to develop a…

  11. Using Flipped Classroom Approach to Explore Deep Learning in Large Classrooms

    Science.gov (United States)

    Danker, Brenda

    2015-01-01

    This project used two Flipped Classroom approaches to stimulate deep learning in large classrooms during the teaching of a film module as part of a Diploma in Performing Arts course at Sunway University, Malaysia. The flipped classes utilized either a blended learning approach where students first watched online lectures as homework, and then…

  12. Flipped Classrooms: An Agenda for Innovative Marketing Education in the Digital Era

    Science.gov (United States)

    Green, Teegan

    2015-01-01

    Flipped classrooms reverse traditional lecturing because students learn content before class through readings and prerecorded videos, freeing lectures for hands-on activities and discussion. However, there is a dearth of literature in marketing education addressing flipped classrooms. This article fills this void using grounded theory to develop a…

  13. CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells.

    Science.gov (United States)

    Llobet, D; Eritja, N; Encinas, M; Llecha, N; Yeramian, A; Pallares, J; Sorolla, A; Gonzalez-Tallada, F J; Matias-Guiu, X; Dolcet, X

    2008-04-17

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has emerged as a promising antineoplastic agent because of its ability to selectively kill tumoral cells. However, some cancer cells are resistant to TRAIL-induced apoptosis. We have previously demonstrated that in endometrial carcinoma cells such resistance is caused by elevated FLICE-inhibitory protein (FLIP) levels. The present study focuses on the mechanisms by which FLIP could be modulated to sensitize endometrial carcinoma cells to TRAIL-induced apoptosis. We find that inhibition of casein kinase (CK2) sensitizes endometrial carcinoma cells to TRAIL- and Fas-induced apoptosis. CK2 inhibition correlates with a reduction of FLIP protein, suggesting that CK2 regulates resistance to TRAIL and Fas by controlling FLIP levels. FLIP downregulation correlates with a reduction of mRNA and is prevented by addition of the MG-132, suggesting that CK2 inhibition results in a proteasome-mediated degradation of FLIP. Consistently, forced expression of FLIP restores resistance to TRAIL and Fas. Moreover, knockdown of either FADD or caspase-8 abrogates apoptosis triggered by inhibition of CK2, indicating that CK2 sensitization requires formation of functional DISC. Finally, because of the possible role of both TRAIL and CK2 in cancer therapy, we demonstrate that CK2 inhibition sensitizes primary endometrial carcinoma explants to TRAIL apoptosis. In conclusion, we demonstrate that CK2 regulates endometrial carcinoma cell sensitivity to TRAIL and Fas by regulating FLIP levels.

  14. The Effect of Flipped Learning (Revised Learning) on Iranian Students' Learning Outcomes

    Science.gov (United States)

    Yousefzadeh, Malahat; Salimi, Asghar

    2015-01-01

    The purpose of this study was to investigate whether the flipped (revised) learning had effect on student learning outcome. Lage et al (2000) describes the flipped classroom as " Inverting the classroom means that events that have traditionally take place inside the classroom now take place outside the class and vice versa" (p.32). The…

  15. A Half-Flipped Classroom or an Alternative Approach?: Primary Sources and Blended Learning

    Science.gov (United States)

    Westermann, Edward B.

    2014-01-01

    This paper examines an alternate approach to the "flipped" classroom paradigm for an upper level history class using a blended on-line and in-class format. The concept of the flipped classroom has received increasing emphasis based on its potential to create a student-centered learning environment that incorporates practical instruction…

  16. Academic Achievements and Satisfaction of the Clicker-Aided Flipped Business English Writing Class

    Science.gov (United States)

    Zhonggen, Yu; Guifang, Wang

    2016-01-01

    The flipped classroom has been achieving a great success in teaching innovation. This study, aiming to determine the effectiveness of the flipped model in business English writing course, combined the quantitative with the qualitative research methods. Participants were randomly selected from undergraduate students majoring in business English.…

  17. Flipping the Classroom: A Case Study of a Mathematics Methods Class

    Science.gov (United States)

    Muir, Tracey; Chick, Helen

    2014-01-01

    The "flipped classroom" is gaining popularity in a number of settings, including secondary schools, reflecting a belief that the approach is more engaging and effective for students. This paper reports on a senior secondary mathematics class's experience with adopting a flipped classroom approach. The findings indicate that the teacher…

  18. An Application of Flipped Classroom Method in the Instructional Technologies and Material Development Course

    Science.gov (United States)

    Özpinar, Ilknur; Yenmez, Arzu Aydogan; Gökçe, Semirhan

    2016-01-01

    A natural outcome of change in technology, new approaches towards teaching and learning have emerged and the applicability of the flipped classroom method, a new educational strategy, in the field of education has started to be discussed. It was aimed with the study to examine the effect of using flipped classroom method in academic achievements…

  19. The Effect of Flipped Model of Instruction on EFL Learners' Reading Comprehension: Learners' Attitudes in Focus

    Science.gov (United States)

    Karimi, Mehrnoosh; Hamzavi, Raouf

    2017-01-01

    The present study aimed at investigating the effect of flipped model of instruction on EFL learners' reading comprehension ability. Moreover, this study aimed at identifying EFL students' attitudes toward flipped model of instruction. To this end, 60 EFL learners studying at an accredited private language institute in Isfahan were first…

  20. How A Flipped Learning Environment Affects Learning In A Course On Theoretical Computer Science

    DEFF Research Database (Denmark)

    Gnaur, Dorina; Hüttel, Hans

    2014-01-01

    This paper reports initial experiences with flipping the classroom in an undergraduate computer science course as part of an overall attempt to enhance the pedagogical support for student learning. Our findings indicate that, just as the flipped classroom implies, a shift of focus in the learning...

  1. Wikis, Workshops and Writing: Strategies for Flipping a College Community Engagement Course

    Science.gov (United States)

    Maloy, Robert W.; Edwards, Sharon A.; Evans, Allison

    2014-01-01

    This paper describes utilizing wiki technology, small group workshops, and reflective writing assignments to "flip" a community engagement/service-learning course for college undergraduates who are tutoring culturally and linguistically diverse students in K-12 schools. Flipped classrooms are gaining popularity in the teaching of…

  2. Implementing a Flipped Instructional Model in College Algebra: Profiles of Student Activity

    Science.gov (United States)

    Lesseig, Kristin; Krouss, Paul

    2017-01-01

    Flipped instruction is increasing in popularity, however research that moves beyond descriptions of its implementation in mathematics classes is lacking. We sought to better understand how students taking an introductory college algebra course used the resources provided within a flipped instructional model and how students viewed such resources…

  3. Flipped Statistics Class Results: Better Performance than Lecture over One Year Later

    Science.gov (United States)

    Winquist, Jennifer R.; Carlson, Keith A.

    2014-01-01

    In this paper, we compare an introductory statistics course taught using a flipped classroom approach to the same course taught using a traditional lecture based approach. In the lecture course, students listened to lecture, took notes, and completed homework assignments. In the flipped course, students read relatively simple chapters and answered…

  4. Using a Flipped Spoon to Decrease Packing in Children with Feeding Disorders

    Science.gov (United States)

    Volkert, Valerie M.; Vaz, Petula C. M.; Piazza, Cathleen C.; Frese, Jana; Barnett, Lara

    2011-01-01

    We evaluated the effects of redistribution and swallow facilitation with a flipped spoon on packing in 2 children with a feeding disorder. For both participants, packing decreased when we implemented the flipped spoon treatment package. Mechanisms responsible for behavior change and areas of future research are discussed. (Contains 1 figure.)

  5. The Impact of the Flipped Classroom on Mathematics Concept Learning in High School

    Science.gov (United States)

    Bhagat, Kaushal Kumar; Chang, Cheng-Nan; Chang, Chun-Yen

    2016-01-01

    The present study aimed to examine the effectiveness of the flipped classroom learning environment on learner's learning achievement and motivation, as well as to investigate the effects of flipped classrooms on learners with different achievement levels in learning mathematics concepts. The learning achievement and motivation were measured by the…

  6. The Flipped Classroom: Implementing Technology to Aid in College Mathematics Student's Success

    Science.gov (United States)

    Buch, George R.; Warren, Carryn B.

    2017-01-01

    August 2016 there was a call (Braun, Bremser, Duval, Lockwood & White, 2017) for post-secondary instructors to use active learning in their classrooms. Once such example of active learning is what is called the "flipped" classroom. This paper presents the need for, and the methodology of the flipped classroom, results of…

  7. Quality-Improving Strategies of College English Teaching Based on Microlesson and Flipped Classroom

    Science.gov (United States)

    Zhang, Fan

    2017-01-01

    Microlesson and flipped classroom, which incorporate the educational information technologies, are a new trend of college English teaching. Exploration on how the flipped classroom and microlesson promote innovation and application of educational information technology are of great significance. According to a survey among teachers, strategies…

  8. A Quantitative Evaluation of the Flipped Classroom in a Large Lecture Principles of Economics Course

    Science.gov (United States)

    Balaban, Rita A.; Gilleskie, Donna B.; Tran, Uyen

    2016-01-01

    This research provides evidence that the flipped classroom instructional format increases student final exam performance, relative to the traditional instructional format, in a large lecture principles of economics course. The authors find that the flipped classroom directly improves performance by 0.2 to 0.7 standardized deviations, depending on…

  9. The Role of Flipped Learning in Managing the Cognitive Load of a Threshold Concept in Physiology

    Science.gov (United States)

    Akkaraju, Shylaja

    2016-01-01

    To help students master challenging, threshold concepts in physiology, I used the flipped learning model in a human anatomy and physiology course with very encouraging results in terms of student motivation, preparedness, engagement, and performance. The flipped learning model was enhanced by pre-training and formative assessments that provided…

  10. Exploring a Flipped Classroom Approach in a Japanese Language Classroom: A Mixed Methods Study

    Science.gov (United States)

    Prefume, Yuko Enomoto

    2015-01-01

    A flipped classroom approach promotes active learning and increases teacher-student interactions by maximizing face-to-face class time (Hamdan, McKnight, Mcknight, Arfstrom, & Arfstrom, 2013). In this study, "flipped classroom" is combined with the use of technology and is described as an instructional approach that provides lectures…

  11. E-Learning and Flipped Instruction Integration in Business Education: A Proposed Pedagogical Model

    Science.gov (United States)

    King, Chula; Piotrowski, Chris

    2015-01-01

    While Blended pedagogical approaches are a ubiquitous feature in higher education, the Flipped class is a rather recent instructional format in undergraduate-level instruction. The Flipped paradigm blends together many of the benefits of E-Learning courses, with many of the benefits of face-to-face instruction. At the same time, the disadvantages…

  12. A Study on the Motivational Strategies in College English Flipped Classroom

    Science.gov (United States)

    Suo, Jia; Hou, Xiuying

    2017-01-01

    Flipped classroom is a great reform that brings a huge impact on the classroom teaching. Its essence is autonomous leaning, whose effect is determined by students' motivation. Therefore, to bring the advantages of the flipped classroom into full play, the top priority is to stimulate students' motivation. The paper makes a study on the…

  13. Flipping an Introductory Biostatistics Course: A Case Study of Student Attitudes and Confidence

    Science.gov (United States)

    Loux, Travis M.; Varner, Sara Emily; VanNatta, Matthew

    2016-01-01

    Flipped classrooms have become an interesting alternative to traditional lecture-based courses throughout the undergraduate curriculum. In this article, we compare a flipped classroom approach to the traditional lecture-based approach to teaching introductory biostatistics to first-year graduate students in public health. The traditional course…

  14. Four Perspectives on Flipping the Statistics Classroom: Changing Pedagogy to Enhance Student-Centered Learning

    Science.gov (United States)

    Kuiper, Shonda R.; Carver, Robert H.; Posner, Michael A.; Everson, Michelle G.

    2015-01-01

    The term "flipped" or "inverted" classroom includes a broad range of pedagogical innovations, and has recently received a significant amount of press. Although flipping an entire course might be a more extreme step than most are able to take, we discuss modular ideas for change that can be more easily implemented. This paper…

  15. Diphoton resonance in F-theory inspired flipped SO(10)

    Energy Technology Data Exchange (ETDEWEB)

    Leontaris, George K. [Ioannina University, Physics Department, Theory Division, Ioannina (Greece); Shafi, Qaisar [University of Delaware, Department of Physics and Astronomy, Bartol Research Institute, Newark, DE (United States)

    2016-10-15

    Motivated by the di-photon excess at 750 GeV reported by the ATLAS and CMS experiments, we present an F-theory inspired flipped SO(10) model embedded in E{sub 6}. The low energy spectrum includes the three MSSM chiral families, vector-like colour triplets, several pairs of charged SU(2){sub L} singlet fields (E{sup c}, anti E{sup c}), as well as MSSM singlets, one or more of which could contribute to the di-photon resonance. A total decay width in the multi-GeV range can arise from couplings involving the singlet and MSSM fields. (orig.)

  16. Repositioning of malpositioned or flipped central venous catheters

    Energy Technology Data Exchange (ETDEWEB)

    Thalhammer, A.; Jacobi, V.; Balzer, J.; Vogl, T.J. [Institute for Diagnostic and Interventional Radiology, Central Radiology Clinic, J.W. Goethe University, Frankfurt am Main (Germany)

    2002-03-01

    Primary misplaced or secondary flipped implanted catheters are located mostly in the right jugular vein. We demonstrate an effective method to replace fix implanted catheters such as Ports, Grochomg or Hickman catheters. Using a femoral venous approach, replacement into the superior vena cava can easily be done with a Sidewinder 1 catheter which is hooked over the misplaced central venous approach. In all our patients the method was successful. The repositioning technique described is simple, fast and has low costs. We can keep sterile conditions and do not need to solve the catheters' fixation. (orig.)

  17. Spin flipping in ring-coupled-cluster-doubles theory

    DEFF Research Database (Denmark)

    Klopper, Wim; M. Teale, Andrew; Coriani, Sonia

    2011-01-01

    We report a critical analysis and comparison of a variety of random-phase-approximation (RPA) based approaches to determine the electronic ground-state energy. Interrelations between RPA variants are examined by numerical examples with particular attention paid to the role of spin-flipped excitat......We report a critical analysis and comparison of a variety of random-phase-approximation (RPA) based approaches to determine the electronic ground-state energy. Interrelations between RPA variants are examined by numerical examples with particular attention paid to the role of spin...

  18. Periodic solutions and flip bifurcation in a linear impulsive system

    Institute of Scientific and Technical Information of China (English)

    Jiang Gui-Rong; Yang Qi-Gui

    2008-01-01

    In this paper,the dynamical behaviour of a linear impulsive system is discussed both theoretically and numerically.The existence and the stability of period-one solution are discussed by using a discrete map.The conditions of existence for flip bifurcation are derived by using the centre manifold theorem and bifurcation theorem.The bifurcation analysis shows that chaotic solutions appear via a cascade of period-doubling in some interval of parameters.Moreover,the periodic solutions,the bifurcation diagram,and the chaotic attractor,which show their consistence with the theoretical analyses,are given in an example.中图分类:O547

  19. Simulation des Underfill-Prozesses bei Flip Chip-Anwendungen

    OpenAIRE

    Häußermann, Tanja

    2009-01-01

    Flip Chips sind elektronische Bauteile, die über leitfähige Höcker, so genannte Bumps, mit der aktiven Seite nach unten direkt auf dem Träger kontaktiert werden. Am häufigsten werden die Chips mit Hilfe von Lotbumps mit organischen Substraten verbunden. Nach dem Löten wird der Spalt zwischen Chip und Substrat komplett mit einem nicht leitfähigen Klebstoff, dem so genannten Underfiller, aufgefüllt. Der flüssige Underfiller wird entlang einer oder mehrerer Chipkanten appliziert, durch Kapillarw...

  20. Realizing quantum controlled phase flip through cavity QED

    Science.gov (United States)

    Xiao, Yun-Feng; Lin, Xiu-Min; Gao, Jie; Yang, Yong; Han, Zheng-Fu; Guo, Guang-Can

    2004-10-01

    We propose a scheme to realize quantum controlled phase flip (CPF) between two rare-earth ions embedded in the respective microsphere cavity via interacting with a single-photon pulse in sequence. The numerical simulations illuminate that the CPF gate between ions is robust and scalable with extremely high fidelity and low error rate. Our scheme is more applicable than other schemes presented before based on current laboratory cavity-QED technology, and it is possible to be used as an applied unit gate in future quantum computation and quantum communication.

  1. Realizing Quantum Controlled Phase Flip through Cavity-QED

    CERN Document Server

    Xiao, Y F; Gao, J; Yang, Y; Han, Z F; Guo, G C; Xiao, Yun-Feng; Lin, Xiu-Min; Gao, Jie; Yang, Yong; Han, Zheng-Fu; Guo, Guang-Can

    2004-01-01

    We propose a scheme to realize quantum controlled phase flip (CPF) between two rare earth ions embedded in respective microsphere cavity via interacting with a single-photon pulse in sequence. The numerical simulations illuminate that the CPF gate between ions is robust and scalable with extremely high fidelity and low error rate. Our scheme is more applicable than other schemes presented before based on current laboratory cavity-QED technology, and it is possible to be used as an applied unit gate in future quantum computation and quantum communication.

  2. Impact of the Flipped Classroom on Student Performance and Retention: A Parallel Controlled Study in General Chemistry

    Science.gov (United States)

    Ryan, Michael D.; Reid, Scott A.

    2016-01-01

    Despite much recent interest in the flipped classroom, quantitative studies are slowly emerging, particularly in the sciences. We report a year-long parallel controlled study of the flipped classroom in a second-term general chemistry course. The flipped course was piloted in the off-semester course in Fall 2014, and the availability of the…

  3. Impact of the Flipped Classroom on Student Performance and Retention: A Parallel Controlled Study in General Chemistry

    Science.gov (United States)

    Ryan, Michael D.; Reid, Scott A.

    2016-01-01

    Despite much recent interest in the flipped classroom, quantitative studies are slowly emerging, particularly in the sciences. We report a year-long parallel controlled study of the flipped classroom in a second-term general chemistry course. The flipped course was piloted in the off-semester course in Fall 2014, and the availability of the…

  4. Photoelectric angle converter

    Science.gov (United States)

    Podzharenko, Volodymyr A.; Kulakov, Pavlo I.

    2001-06-01

    The photo-electric angle transmitter of rotation is offered, at which the output voltage is linear function of entering magnitude. In a transmitter the linear phototransducer is used on the basis of pair photo diode -- operating amplifier, which output voltage is linear function of the area of an illuminated photosensitive stratum, and modulator of a light stream of the special shape, which ensures a linear dependence of this area from an angle of rotation. The transmitter has good frequent properties and can be used for dynamic measurements of an angular velocity and angle of rotation, in systems of exact drives and systems of autocontrol.

  5. Student Performance in a Pharmacotherapy Oncology Module Before and After Flipping the Classroom.

    Science.gov (United States)

    Bossaer, John B; Panus, Peter; Stewart, David W; Hagemeier, Nick E; George, Joshua

    2016-03-25

    Objective. To determine if a flipped classroom improved student examination performance in a pharmacotherapy oncology module. Design. Third-year pharmacy students in 2012 experienced the oncology module as interactive lectures with optional case studies as supplemental homework. In 2013, students experienced the same content in a primarily flipped classroom. Students were instructed to watch vodcasts (video podcasts) before in-class case studies but were not held accountable (ie, quizzed) for preclass preparation. Examination questions were identical in both cohorts. Performance on examination questions was compared between the two cohorts using analysis of covariance (ANCOVA), with prior academic performance variables (grade point average [GPA]) as covariates. Assessment. The students who experienced the flipped classroom approach performed poorer on examination questions than the cohort who experienced interactive lecture, with previous GPA used as a covariate. Conclusion. A flipped classroom does not necessarily improve student performance. Further research is needed to determine optimal classroom flipping techniques.

  6. Nursing students’ experiences, perceptions and behavior in a flipped-classroom anatomy and physiology course

    DEFF Research Database (Denmark)

    Mikkelsen, Thomas Raundahl

    2015-01-01

    Objective: The aim of this study was to explore nursing students’ experiences, perceptions and behavior during a course on kidney and urinary system anatomy and physiology designed according to the flipped-classroom approach. In flipped-classroom teaching, students prepare for class by engaging...... with teacher-produced learning material, typically videos. This frees up time in class, which can instead be spent on various student-centered, active-learning activities. Only very few studies on the use of flipped classroom in nursing education have been published. Methods: Videos and active...... believed that the videos were better than face-to-face lectures with regard to learning outcome, 56% felt they were of equal benefit, and only 18% benefited most from face-to-face lectures. Only a small minority (18%) preferred traditional teaching over flipped classroom teaching, 41% preferred flipped...

  7. All-optical flip-flop based on vertical cavity semiconductor optical amplifiers.

    Science.gov (United States)

    Song, Deqiang; Gauss, Veronica; Zhang, Haijiang; Gross, Matthias; Wen, Pengyue; Esener, Sadik

    2007-10-15

    We report the operation of an all-optical set-reset (SR) flip-flop based on vertical cavity semiconductor optical amplifiers (VCSOAs). This flip-flop is cascadable, has low optical switching power (~10 microW), and has the potential to be integrated on a small footprint (~100 microm(2)). The flip-flop is composed of two cross-coupled electrically pumped VCSOA inverters and uses the principles of cross-gain modulation, polarization gain anisotropy, and highly nonlinear gain characteristics to achieve flip-flop functionality. We believe that, when integrated on chip, this type of all-optical flip-flop opens new prospects for implementing all-optical fast memories and timing regeneration circuits.

  8. Applying a learning design methodology in the flipped classroom approach – empowering teachers to reflect

    DEFF Research Database (Denmark)

    Triantafyllou, Evangelia; Kofoed, Lise; Purwins, Hendrik

    2016-01-01

    , while class time is devoted to clarifications and application of this knowledge. The hypothesis is that there could be deep and creative discussions when teacher and students physically meet. This paper discusses how the learning design methodology can be applied to represent, share and guide educators......One of the recent developments in teaching that heavily relies on current technology is the “flipped classroom” approach. In a flipped classroom the traditional lecture and homework sessions are inverted. Students are provided with online material in order to gain necessary knowledge before class...... through flipped classroom designs. In order to discuss the opportunities arising by this approach, the different components of the Learning Design – Conceptual Map (LD-CM) are presented and examined in the context of the flipped classroom. It is shown that viewing the flipped classroom through the lens...

  9. Design of ternary low-power Domino JKL flip-flop and its application

    Institute of Scientific and Technical Information of China (English)

    Wang Pengjun; Yang Qiankun; Zheng Xuesong

    2012-01-01

    By researching the ternary flip-flop and the adiabatic Domino circuit,a novel design of low-power ternary Domino JKL flip-flop on the switch level is proposed.First,the switch-level structure of the ternary adiabatic Domino JKL flip-flop is derived according to the switch-signal theory and its truth table.Then the ternary loop operation circuit and ternary reverse loop operation circuit are achieved by employing the ternary JKL flip-flop.Finally,the circuit is simulated by using the Spice tool and the results show that the logic function is correct.The energy consumption of the ternary adiabatic Domino JKL flip-flop is 69% less than its conventional Domino counterpart.

  10. Spin-polarized free electron beam interaction with radiation and superradiant spin-flip radiative emission

    Directory of Open Access Journals (Sweden)

    A. Gover

    2006-06-01

    Full Text Available The problems of spin-polarized free-electron beam interaction with electromagnetic wave at electron-spin resonance conditions in a magnetic field and of superradiant spin-flip radiative emission are analyzed in the framework of a comprehensive classical model. The spontaneous emission of spin-flip radiation from electron beams is very weak. We show that the detectivity of electron spin resonant spin-flip and combined spin-flip/cyclotron-resonance-emission radiation can be substantially enhanced by operating with ultrashort spin-polarized electron beam bunches under conditions of superradiant (coherent emission. The proposed radiative spin-state modulation and the spin-flip radiative emission schemes can be used for control and noninvasive diagnostics of polarized electron/positron beams. Such schemes are of relevance in important scattering experiments off nucleons in nuclear physics and off magnetic targets in condensed matter physics.

  11. The flipped classroom: A learning model to increase student engagement not academic achievement

    Directory of Open Access Journals (Sweden)

    Masha Smallhorn

    2017-07-01

    Full Text Available A decrease in student attendance at lectures both nationally and internationally, has prompted educators to re-evaluate their teaching methods and investigate strategies which promote student engagement. The flipped classroom model, grounded in active learning pedagogy, transforms the face-to-face classroom. Students prepare for the flipped classroom in their own time by watching short online videos and completing readings. Face-to-face time is used to apply learning through problem-solving with peers. To improve the engagement and learning outcomes of our second year cohort, lectures were replaced with short online videos and face-to-face time was spent in a flipped classroom. The impact of the flipped classroom was analysed through surveys, attendance records, learning analytics and exam data before and after the implementation of the flipped classroom. Results suggest an increase in student engagement and a positive attitude towards the learning method. However, there were no measurable increases in student learning outcomes.

  12. Shock-induced poration, cholesterol flip-flop and small interfering RNA transfection in a phospholipid membrane: Multimillion atom, microsecond molecular dynamics simulations

    Science.gov (United States)

    Choubey, Amit

    Biological cell membranes provide mechanical stability to cells and understanding their structure, dynamics and mechanics are important biophysics problems. Experiments coupled with computational methods such as molecular dynamics (MD) have provided insight into the physics of membranes. We use long-time and large-scale MD simulations to study the structure, dynamics and mechanical behavior of membranes. We investigate shock-induced collapse of nanobubbles in water using MD simulations based on a reactive force field. We observe a focused jet at the onset of bubble shrinkage and a secondary shock wave upon bubble collapse. The jet length scales linearly with the nanobubble radius, as observed in experiments on micron-to-millimeter size bubbles. Shock induces dramatic structural changes, including an ice-VII-like structural motif at a particle velocity of 1 km/s. The incipient ice VII formation and the calculated Hugoniot curve are in good agreement with experimental results. We also investigate molecular mechanisms of poration in lipid bilayers due to shock-induced collapse of nanobubbles. Our multimillion-atom MD simulations reveal that the jet impact generates shear flow of water on bilayer leaflets and pressure gradients across them. This transiently enhances the bilayer permeability by creating nanopores through which water molecules translocate rapidly across the bilayer. Effects of nanobubble size and temperature on the porosity of lipid bilayers are examined. The second research project focuses on cholesterol (CHOL) dynamics in phospholipid bilayers. Several experimental and computational studies have been performed on lipid bilayers consisting of dipalmitoylphosphatidylcholine (DPPC) and CHOL molecules. CHOL interleaflet transport (flip-flop) plays an important role in interleaflet coupling and determining CHOL flip-flop rate has been elusive. Various studies report that the rate ranges between milliseconds to seconds. We calculate CHOL flip-flop rates by

  13. killerFLIP: a novel lytic peptide specifically inducing cancer cell death.

    Science.gov (United States)

    Pennarun, B; Gaidos, G; Bucur, O; Tinari, A; Rupasinghe, C; Jin, T; Dewar, R; Song, K; Santos, M T; Malorni, W; Mierke, D; Khosravi-Far, R

    2013-10-31

    One of the objectives in the development of effective cancer therapy is induction of tumor-selective cell death. Toward this end, we have identified a small peptide that, when introduced into cells via a TAT cell-delivery system, shows a remarkably potent cytoxicity in a variety of cancer cell lines and inhibits tumor growth in vivo, whereas sparing normal cells and tissues. This fusion peptide was named killerFLIP as its sequence was derived from the C-terminal domain of c-FLIP, an anti-apoptotic protein. Using structure activity analysis, we determined the minimal bioactive core of killerFLIP, namely killerFLIP-E. Structural analysis of cells using electron microscopy demonstrated that killerFLIP-E triggers cell death accompanied by rapid (within minutes) plasma membrane permeabilization. Studies of the structure of the active core of killerFLIP (-E) indicated that it possesses amphiphilic properties and self-assembles into micellar structures in aqueous solution. The biochemical properties of killerFLIP are comparable to those of cationic lytic peptides, which participate in defense against pathogens and have also demonstrated anticancer properties. We show that the pro-cell death effects of killerFLIP are independent of its sequence similarity with c-FLIPL as killerFLIP-induced cell death was largely apoptosis and necroptosis independent. A killerFLIP-E variant containing a scrambled c-FLIPL motif indeed induced similar cell death, suggesting the importance of the c-FLIPL residues but not of their sequence. Thus, we report the discovery of a promising synthetic peptide with novel anticancer activity in vitro and in vivo.

  14. Investigating Flipped Learning: Student Self-Regulated Learning, Perceptions, and Achievement in an Introductory Biology Course

    Science.gov (United States)

    Sletten, Sarah Rae

    2017-01-01

    In flipped classrooms, lectures, which are normally delivered in-class, are assigned as homework in the form of videos, and assignments that were traditionally assigned as homework, are done as learning activities in class. It was hypothesized that the effectiveness of the flipped model hinges on a student's desire and ability to adopt a self-directed learning style. The purpose of this study was twofold; it aimed at examining the relationship between two variables—students' perceptions of the flipped model and their self-regulated learning (SRL) behaviors—and the impact that these variables have on achievement in a flipped class. For the study, 76 participants from a flipped introductory biology course were asked about their SRL strategy use and perceptions of the flipped model. SRL strategy use was measured using a modified version of the Motivated Strategies for Learning Questionnaire (MSLQ; Wolters et al. 2005), while the flipped perceptions survey was newly derived. Student letter grades were collected as a measure of achievement. Through regression analysis, it was found that students' perceptions of the flipped model positively predict students' use of several types of SRL strategies. However, the data did not indicate a relationship between student perceptions and achievement, neither directly nor indirectly, through SRL strategy use. Results suggest that flipped classrooms demonstrate their successes in the active learning sessions through constructivist teaching methods. Video lectures hold an important role in flipped classes, however, students may need to practice SRL skills to become more self-directed and effectively learn from them.

  15. Investigating Flipped Learning: Student Self-Regulated Learning, Perceptions, and Achievement in an Introductory Biology Course

    Science.gov (United States)

    Sletten, Sarah Rae

    2017-06-01

    In flipped classrooms, lectures, which are normally delivered in-class, are assigned as homework in the form of videos, and assignments that were traditionally assigned as homework, are done as learning activities in class. It was hypothesized that the effectiveness of the flipped model hinges on a student's desire and ability to adopt a self-directed learning style. The purpose of this study was twofold; it aimed at examining the relationship between two variables—students' perceptions of the flipped model and their self-regulated learning (SRL) behaviors—and the impact that these variables have on achievement in a flipped class. For the study, 76 participants from a flipped introductory biology course were asked about their SRL strategy use and perceptions of the flipped model. SRL strategy use was measured using a modified version of the Motivated Strategies for Learning Questionnaire (MSLQ; Wolters et al. 2005), while the flipped perceptions survey was newly derived. Student letter grades were collected as a measure of achievement. Through regression analysis, it was found that students' perceptions of the flipped model positively predict students' use of several types of SRL strategies. However, the data did not indicate a relationship between student perceptions and achievement, neither directly nor indirectly, through SRL strategy use. Results suggest that flipped classrooms demonstrate their successes in the active learning sessions through constructivist teaching methods. Video lectures hold an important role in flipped classes, however, students may need to practice SRL skills to become more self-directed and effectively learn from them.

  16. Flipping around the classroom: Accelerated Bachelor of Science in Nursing students' satisfaction and achievement.

    Science.gov (United States)

    El-Banna, Majeda M; Whitlow, Malinda; McNelis, Angela M

    2017-09-01

    The flipped classroom approach is based on shared responsibility for learning by students and teachers, and empowers students to take an active role in the learning process. While utilization of this approach has resulted in higher exam scores compared to traditional approaches in prior studies, the flipped classroom has not included learners in Accelerated Bachelor of Science in Nursing (ABSN) programs. To examine differences on exam scores and satisfaction of teaching between a 3-week flipped and traditional classroom approach. Mixed methods, crossover repeated measures design. Private school of nursing located in the eastern United States. 76 ABSN students. Two separate sections of a Pharmacology course received either 3-weeks of flipped or traditional classroom during Period 1, then switched approaches during Period 2. Two exam scores measuring knowledge and a questionnaire assessing satisfaction of teaching were collected. Focus groups were conducted to learn about students' experience in the flipped classroom. Descriptive statistics, Wilcoxon rank sum test, and stepwise linear mixed model were used to analyze quantitative data. Focus group data were transcribed, coded, and categorized in themes. Students in the flipped classroom achieved significantly higher scores on the first Pharmacology exam than students in the traditional classroom, but there was no significant difference on the second exam. Three themes emerged from focus groups on student perception of integrating the flipped approach: don't fix what isn't broken; treat me as an adult; and remember the work is overwhelming. Both traditional and flipped classroom approaches successfully prepared students for the Pharmacology exams. While results support the use of the flipped approach, judicious use of this instructional pedagogy with dense or difficult content, particularly in accelerated programs, is recommended. Instructors should also provide students with enough information and rationale for using

  17. Angle-Ply Weaving

    Science.gov (United States)

    Farley, Gary L.

    1990-01-01

    Bias-direction or angle-ply weaving is proposed new process for weaving fibers along bias in conventional planar fabric or in complicated three-dimensional multilayer fabric preform of fiber-reinforced composite structure. Based upon movement of racks of needles and corresponding angle yarns across fabric as fabric being formed. Fibers woven along bias increases shear stiffness and shear strength of preform, increasing value of preform as structural member.

  18. Towards a Data Reduction for the Minimum Flip Supertree Problem

    CERN Document Server

    Böcker, Sebastian

    2011-01-01

    In computational phylogenetics, the problem of constructing a supertree of a given set of rooted input trees can be formalized in different ways, to cope with contradictory information in the input. We consider the Minimum Flip Supertree problem, where the input trees are transformed into a 0/1/?-matrix, such that each row represents a taxon, and each column represents an inner node of one of the input trees. Our goal is to find a perfect phylogeny for the input matrix requiring a minimum number of 0/1-flips, that is, corrections of 0/1-entries in the matrix. The problem is known to be NP-complete. Here, we present a parameterized data reduction with polynomial running time. The data reduction guarantees that the reduced instance has a solution if and only if the original instance has a solution. We then make our data reduction parameter-independent by using upper bounds. This allows us to preprocess an instance, and to solve the reduced instance with an arbitrary method. Different from an existing data reduc...

  19. Just do it: flipped lecture, determinants and debate

    Science.gov (United States)

    Kensington-Miller, Barbara; Novak, Julia; Evans, Tanya

    2016-08-01

    This paper describes a case study of two pure mathematicians who flipped their lecture to teach matrix determinants in two large mathematics service courses (one at Stage I and the other at Stage II). The purpose of the study was to transform the passive lecture into an active learning opportunity and to introduce valuable mathematical skills, such as debate, argument and disagreement. The students were told in advance to use the online material to prepare, which had a short handout on matrix determinants posted, as the lesson would be interactive and would rely on them having studied this. At the beginning of the lesson, the two mathematicians worked together to model the skill of professional disagreement, one arguing for the cofactor expansion method and the other for the row reduction method. After voting for their preferred method, the students worked in small groups on examples to defend their choice. Each group elected a spokesperson and a political style debate followed as the students argued the pros and cons of each technique. Although one lecture does not establish whether the flipped lecture model is preferable for student instruction, the paper presents a case study for pursuing this approach and for further research on incorporating this style of teaching in Science, Technology, Engineering and Mathematics subjects.

  20. Rare B decays in the flip SU(5) Model

    CERN Document Server

    Li, Tianjun; Wang, Wenyu; Wang, Xiao-Chuan; Xiong, Zhao-Hua

    2012-01-01

    In the testable Flipped $SU(5)\\times U(1)_X$ model with TeV-scale vector-like particles from F-theory model building dubbed as the flip SU(5) model, we study the vector-like quark contributions to B physics processes, including the quark mass spectra, Feynman rules, new operators and Wilson coefficients, etc. We focus on the implications of the vector-like quark mass scale on B physics. We find that there exists the $\\bar{s}bZ$ interaction at tree level, and the Yukawa interactions are changed. Interestingly, different from many previous models, the effects of vector-like quarks on rare B decays such as $B\\to X_s\\gamma$ and $B\\to X_s\\ell^+\\ell^-$ do not decouple in some viable parameter space, especially when the vector-like quark masses are comparable to the charged Higgs boson mass. Under the constraints from $B\\to X_s\\gamma$ and $\\ B\\to X_s\\ell^+\\ell^-$, the latest measurement for $B_s\\to \\mu^+\\mu^-$ can be explained naturally, and the branching ratio of $B_s\\to \\ell^+\\ell^-\\gamma$ can be up to $(4\\sim5)\\t...

  1. Classification of Flipped SU(5) Heterotic-String Vacua

    CERN Document Server

    Faraggi, Alon; Sonmez, Hasan

    2014-01-01

    We extend the classification of free fermionic heterotic-string vacua to models in which the SO(10) GUT symmetry is reduced at the string level to the flipped SU(5) subgroup. In our classification method the set of boundary condition basis vectors is fixed and the enumeration of string vacua is obtained in terms of the Generalised GSO (GGSO) projection coefficients entering the one-loop partition function. We derive algebraic expressions for the GGSO projections for all the physical states appearing in the sectors generated by the set of basis vectors. This enables the programming of the entire spectrum analysis in a computer code. For that purpose we developed two independent codes, based on FORTRAN95 and JAVA, and all resulted presented are confirmed by the two independent routines. We perform a statistical sampling in the space of 2^{44} ~ 10^{13} flipped SU(5) vacua, and scan up to 10^{12} GGSO configurations. Contrary to the corresponding Pati-Salam classification results, we do not find exophobic flippe...

  2. Flip chip bumping technology-Status and update

    Energy Technology Data Exchange (ETDEWEB)

    Juergen Wolf, M. [Fraunhofer IZM, Gustav-Meyer-Allee 25, 13355 Berlin (Germany)]. E-mail: juergen.Wolf@izm.fraunhofer.de; Engelmann, Gunter [Fraunhofer IZM, Gustav-Meyer-Allee 25, 13355 Berlin (Germany); Dietrich, Lothar [Fraunhofer IZM, Gustav-Meyer-Allee 25, 13355 Berlin (Germany); Reichl, Herbert [Fraunhofer IZM, Gustav-Meyer-Allee 25, 13355 Berlin (Germany)

    2006-09-01

    Flip chip technology is a key driver for new complex system architectures and high-density packaging, e.g. sensor or pixel devices. Bumped wafers/dice as key elements become very important in terms of general availability at low cost, high yield and quality level. Today, different materials, e.g. Au, Ni, AuSn, SnAg, SnAgCu, SnCu, etc., are used for flip chip interconnects and different bumping approaches are available. Electroplating is the technology of choice for high-yield wafer bumping for small bump sizes and pitches. Lead-free solder bumps require an increase in knowledge in the field of under bump metallization (UBM) and the interaction of bump and substrate metallization, the formation and growth of intermetallic compounds (IMCs) during liquid- and solid-phase reactions. Results of a new bi-layer UBM of Ni-Cu which is especially designed for small-sized lead-free solder bumps will be discussed.

  3. High Gradient Accelerator Research

    Energy Technology Data Exchange (ETDEWEB)

    Temkin, Richard [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States). Dept. of Physics. Plasma Science and Fusion Center

    2016-07-12

    The goal of the MIT program of research on high gradient acceleration is the development of advanced acceleration concepts that lead to a practical and affordable next generation linear collider at the TeV energy level. Other applications, which are more near-term, include accelerators for materials processing; medicine; defense; mining; security; and inspection. The specific goals of the MIT program are: • Pioneering theoretical research on advanced structures for high gradient acceleration, including photonic structures and metamaterial structures; evaluation of the wakefields in these advanced structures • Experimental research to demonstrate the properties of advanced structures both in low-power microwave cold test and high-power, high-gradient test at megawatt power levels • Experimental research on microwave breakdown at high gradient including studies of breakdown phenomena induced by RF electric fields and RF magnetic fields; development of new diagnostics of the breakdown process • Theoretical research on the physics and engineering features of RF vacuum breakdown • Maintaining and improving the Haimson / MIT 17 GHz accelerator, the highest frequency operational accelerator in the world, a unique facility for accelerator research • Providing the Haimson / MIT 17 GHz accelerator facility as a facility for outside users • Active participation in the US DOE program of High Gradient Collaboration, including joint work with SLAC and with Los Alamos National Laboratory; participation of MIT students in research at the national laboratories • Training the next generation of Ph. D. students in the field of accelerator physics.

  4. Dropwise condensation on a cold gradient substrate

    Science.gov (United States)

    Macner, Ashley; Daniel, Susan; Steen, Paul

    2012-11-01

    Distributions of drops that arise from dropwise condensation evolve by nucleation, growth, and coalescence of drops. An understanding of how surface-energy gradients applied to the substrate affect drop growth and coalescence is needed for design of effective surfaces for large-scale dropwise condensation. Transient dropwise condensation from a vapor phase onto a cold and chemically treated surface is reported. The surfaces were treated to deliver either a uniform contact-angle or a gradient of contact-angles by silanization. The time evolution of drop-size and number-density distributions is reported. For a typical condensation experiment, the drop distributions advance through two stages: an increase in drop density as a result of nucleation and a decrease in drop density as a result of larger scale coalescence events. Because the experiment is transient in nature, the shape of the distribution can be used to predict the number of drop generations and their stage of development. Preliminary results for gradient surfaces will be discussed and compared against observations of behavior on uniformly coated surfaces. NASA Space Technology Research Fellowship (NSTRF).

  5. Design of non-selective refocusing pulses with phase-free rotation axis by gradient ascent pulse engineering algorithm in parallel transmission at 7T.

    Science.gov (United States)

    Massire, Aurélien; Cloos, Martijn A; Vignaud, Alexandre; Le Bihan, Denis; Amadon, Alexis; Boulant, Nicolas

    2013-05-01

    At ultra-high magnetic field (≥ 7T), B1 and ΔB0 non-uniformities cause undesired inhomogeneities in image signal and contrast. Tailored radiofrequency pulses exploiting parallel transmission have been shown to mitigate these phenomena. However, the design of large flip angle excitations, a prerequisite for many clinical applications, remains challenging due the non-linearity of the Bloch equation. In this work, we explore the potential of gradient ascent pulse engineering to design non-selective spin-echo refocusing pulses that simultaneously mitigate severe B1 and ΔB0 non-uniformities. The originality of the method lays in the optimization of the rotation matrices themselves as opposed to magnetization states. Consequently, the commonly used linear class of large tip angle approximation can be eliminated from the optimization procedure. This approach, combined with optimal control, provides additional degrees of freedom by relaxing the phase constraint on the rotation axis, and allows the derivative of the performance criterion to be found analytically. The method was experimentally validated on an 8-channel transmit array at 7T, using a water phantom with B1 and ΔB0 inhomogeneities similar to those encountered in the human brain. For the first time in MRI, the rotation matrix itself on every voxel was measured by using Quantum Process Tomography. The results are complemented with a series of spin-echo measurements comparing the proposed method against commonly used alternatives. Both experiments confirm very good performance, while simultaneously maintaining a low energy deposition and pulse duration compared to well-known adiabatic solutions. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Uniform gradient expansions

    Directory of Open Access Journals (Sweden)

    Massimo Giovannini

    2015-06-01

    Full Text Available Cosmological singularities are often discussed by means of a gradient expansion that can also describe, during a quasi-de Sitter phase, the progressive suppression of curvature inhomogeneities. While the inflationary event horizon is being formed the two mentioned regimes coexist and a uniform expansion can be conceived and applied to the evolution of spatial gradients across the protoinflationary boundary. It is argued that conventional arguments addressing the preinflationary initial conditions are necessary but generally not sufficient to guarantee a homogeneous onset of the conventional inflationary stage.

  7. Uniform gradient expansions

    Energy Technology Data Exchange (ETDEWEB)

    Giovannini, Massimo, E-mail: massimo.giovannini@cern.ch [Department of Physics, Theory Division, CERN, 1211 Geneva 23 (Switzerland); INFN, Section of Milan-Bicocca, 20126 Milan (Italy)

    2015-06-30

    Cosmological singularities are often discussed by means of a gradient expansion that can also describe, during a quasi-de Sitter phase, the progressive suppression of curvature inhomogeneities. While the inflationary event horizon is being formed the two mentioned regimes coexist and a uniform expansion can be conceived and applied to the evolution of spatial gradients across the protoinflationary boundary. It is argued that conventional arguments addressing the preinflationary initial conditions are necessary but generally not sufficient to guarantee a homogeneous onset of the conventional inflationary stage.

  8. Gradient systems and mechanical systems

    Institute of Scientific and Technical Information of China (English)

    Fengxiang Mei; Huibin Wu

    2016-01-01

    All types of gradient systems and their properties are discussed. Two problems connected with gradient sys-tems and mechanical systems are studied. One is the direct problem of transforming a mechanical system into a gradi-ent system, and the other is the inverse problem, which is transforming a gradient system into a mechanical system.

  9. Students' Perceptions and Emotions Toward Learning in a Flipped General Science Classroom

    Science.gov (United States)

    Jeong, Jin Su; González-Gómez, David; Cañada-Cañada, Florentina

    2016-10-01

    Recently, the inverted instruction methodologies are gaining attentions in higher educations by claiming that flipping the classroom engages more effectively students with the learning process. Besides, students' perceptions and emotions involved in their learning process must be assessed in order to gauge the usability of this relatively new instruction methodology, since it is vital in the educational formation. For this reason, this study intends to evaluate the students' perceptions and emotions when a flipped classroom setting is used as instruction methodology. This research was conducted in a general science course, sophomore of the Primary Education bachelor degree in the Training Teaching School of the University of Extremadura (Spain). The results show that the students have the overall positive perceptions to a flipped classroom setting. Particularly, over 80 % of them considered that the course was a valuable learning experience. They also found this course more interactive and were willing to have more courses following a flipped model. According to the students' emotions toward a flipped classroom course, the highest scores were given to the positive emotions, being fun and enthusiasm along with keyword frequency test. Then, the lowest scores were corresponded to negative emotions, being boredom and fear. Therefore, the students attending to a flipped course demonstrated to have more positive and less negative emotions. The results obtained in this study allow drawing a promising tendency about the students' perceptions and emotions toward the flipped classroom methodology and will contribute to fully frame this relatively new instruction methodology.

  10. The flipped classroom allows for more class time devoted to critical thinking.

    Science.gov (United States)

    DeRuisseau, Lara R

    2016-12-01

    The flipped classroom was utilized in a two-semester, high-content science course that enrolled between 50 and 80 students at a small liberal arts college. With the flipped model, students watched ~20-min lectures 2 days/wk outside of class. These videos were recorded via screen capture and included a detailed note outline, PowerPoint slides, and review questions. The traditional format included the same materials, except that lectures were delivered in class each week and spanned the entire period. During the flipped course, the instructor reviewed common misconceptions and asked questions requiring higher-order thinking, and five graded case studies were performed each semester. To determine whether assessments included additional higher-order thinking skills in the flipped vs. traditional model, questions across course formats were compared via Blooms Taxonomy. Application-level questions that required prediction of an outcome in a new scenario comprised 38 ± 3 vs. 12 ± 1% of summative assessment questions (classroom) compared with their major GPA. These data demonstrate that assessments transitioned to more application-level compared with factual knowledge-based questions with this particular flipped model, and students performed better in their final letter grade compared with the traditional lecture format. Although the benefits to a flipped classroom are highlighted, student evaluations did suffer. More detailed studies comparing the traditional and flipped formats are warranted.

  11. Moving toward heutagogical learning: Illuminating undergraduate nursing students' experiences in a flipped classroom.

    Science.gov (United States)

    Green, Rebecca D; Schlairet, Maura C

    2017-02-01

    Nurse educators rely on the tenets of educational theory and evidence-based education to promote the most effective curriculum and facilitate the best outcomes. The flipped classroom model, in which students assume personal responsibility for knowledge acquisition in a highly engaging and interactive environment, supports self-directed learning and the unique needs of clinical education. To understand how students perceived their experiences in the flipped classroom and how students' learning dispositions were affected by the flipped classroom experience. A phenomenological approach was used to gain deeper understanding about students' perspectives, perceptions and subjective experiences of the flipped classroom model. The focus of the study was on characteristics of student learning. Fourteen Bachelors of Science of Nursing (BSN) students at a regional university in the southeastern United States. Using data transcribed from face-to-face, semi-structured interviews, experiential themes were extracted from the qualitative data (student-reported experiences, attributes, thoughts, values, and beliefs regarding teaching and learning in the context of their experience of the flipped classroom) using Graneheim's and Lundman's (2004) guidelines; and were coded and analyzed within theoretical categories based on pedagogical, andragogical or heutagogical learning dispositions. Experiential themes that emerged from students' descriptions of their experiences in the flipped classroom included discernment, challenge, relevance, responsibility, and expertise. The flipped classroom model offers promising possibilities for facilitating students' movement from learning that is characteristic of pedagogy and andragogy toward heutagogical learning. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. The "flipped classroom" approach: Stimulating positive learning attitudes and improving mastery of histology among medical students.

    Science.gov (United States)

    Cheng, Xin; Ka Ho Lee, Kenneth; Chang, Eric Y; Yang, Xuesong

    2017-07-01

    Traditional medical education methodologies have been dramatically impacted by the introduction of new teaching approaches over the past few decades. In particular, the "flipped classroom" format has drawn a great deal of attention. However, evidence regarding the effectiveness of the flipped model remains limited due to a lack of outcome-based studies. In the present study, a pilot histology curriculum of the organ systems was implemented among 24 Traditional Chinese Medicine (TCM) students in a flipped classroom format at Jinan University. As a control, another 87 TCM students followed a conventional histology curriculum. The academic performance of the two groups was compared. In addition, a questionnaire was administered to the flipped classroom group. The test scores for the flipped classroom participants were found to be significantly higher compared to non-participants in the control group. These results suggest that students may benefit from using the flipped classroom format. Follow-up questionnaires also revealed that most of the flipped classroom participants undertook relatively more earnest preparations before class and were actively involved in classroom learning activities. The teachers were also found to have more class time for leading discussions and delivering quizzes rather than repeating rote didactics. Consequently, the increased teaching and learning activities contributed to a better performance among the flipped classroom group. This pilot study suggests that a flipped classroom approach can be used to improve histology education among medical students. However, future studies employing randomization, larger numbers of students, and more precise tracking methods are needed before definitive conclusions can be drawn. Anat Sci Educ 10: 317-327. © 2016 American Association of Anatomists. © 2016 American Association of Anatomists.

  13. Limited Angle Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ho Kyung; Cho, Min Kook; Kim, Seong Sik [Pusan National University, Busan (Korea, Republic of)

    2007-07-01

    In computed tomography (CT), many situations are restricted to obtain enough number of projections or views to avoid artifacts such as streaking and geometrical distortion in the reconstructed images. Speed of motion of an object to be imaged can limit the number of views. Cardiovascular imaging is a representative example. Size of an object can also limit the complete traverse motion or geometrical complexity can obscure to be imaged at certain range of angles. These situations are frequently met in industrial nondestructive testing and evaluation. Dental CT also suffers from similar situation because cervical spine causes less x-ray penetration from some directions such that the available information is not sufficient for standard reconstruction algorithms. The limited angle tomography is now greatly paid attention as a new genre in medical and industrial imaging, popularly known as digital tomosynthesis. In this study, we introduce a modified filtered backprojection method in limited angle tomography and demonstrate its application for the dental imaging.

  14. Dynamical angled brane

    Science.gov (United States)

    Maeda, Kei-ichi; Uzawa, Kunihito

    2016-12-01

    We discuss the dynamical D p -brane solutions describing any number of D p branes whose relative orientations are given by certain SU(2) rotations. These are the generalization of the static angled D p -brane solutions. We study the collision of the dynamical D3 brane with angles in type-II string theory, and show that the particular orientation of the smeared D3-brane configuration can provide an example of colliding branes if they have the same charges. Otherwise a singularity appears before D3 branes collide.

  15. The flipped classroom, putting learning back into the hands of students

    Science.gov (United States)

    Torkelson, Virginia

    Flipping the classroom is a new style of teaching that puts learning back into the hands of the student and allows the teacher to facilitate each child's learning based on their individual needs. Three units of Chemistry were flipped to give the researcher experience and skill in this new ideology. Technology was used to create podcasts for student's to watch outside of the classroom. Student's used classroom time for problem-solving, activities, discussions and labs. From this experience as well as conferences, classroom observations of the flipping process in action and discussions with other teachers also using this new style of teaching, a handbook was written.

  16. From spin flip excitations to the spin susceptibility enhancement of a two-dimensional electron gas.

    Science.gov (United States)

    Perez, F; Aku-leh, C; Richards, D; Jusserand, B; Smith, L C; Wolverson, D; Karczewski, G

    2007-07-13

    The g-factor enhancement of the spin-polarized two-dimensional electron gas was measured directly over a wide range of spin polarizations, using spin flip resonant Raman scattering spectroscopy on two-dimensional electron gases embedded in Cd(1-x)Mn(x)Te semimagnetic quantum wells. At zero Raman transferred momentum, the single-particle spin flip excitation, energy Z*, coexists in the Raman spectrum with the spin flip wave of energy Z, the bare giant Zeeman splitting. We compare the measured g-factor enhancement with recent spin-susceptibility enhancement theories and deduce the spin-polarization dependence of the mass renormalization.

  17. Rabi oscillation induced $\\pi$-phase flip in an unbalanced Ramsey atom interferometer

    CERN Document Server

    Li, R B; Wang, K; Lu, S B; Cao, L; Wang, J; Zhan, M S

    2016-01-01

    We present an observation of zero to $\\pi$ phase flips induced by Rabi oscillation in an unbalanced Ramsey atom interferometer. The phase shift and visibility are experimentally investigated by modulating either the polarization or the pulse duration of Raman lasers, and they are well explained by a theoretical model. In an atom interferometer, the $\\pi$-phase flips are caused not only by the sign of Rabi frequency but also by the amplitude of Rabi oscillation. Considering these $\\pi$-phase flips, we propose a composite-light-pulse sequence for realizing cold atom interferometers, which has advantages of the large momentum transfer and the better noise immunity.

  18. The impact of Flipped Classroom on the motivation and learning of students in Operations Management

    Directory of Open Access Journals (Sweden)

    Eloísa Díaz Garrido

    2017-06-01

    Full Text Available The objective of this work is to analyze the effectiveness of the Flipped Classroom methodology in the discipline of Operations Management, analyzing for this the motivation of the students and their learning results in terms of the acquisition of skills and qualifications obtained. Specifically, a comparative analysis is carried out with two teaching groups, having applied the methodology of Flipped Classroom only in one of them. -------------- El impacto del flipped classroom en la motivación y en el aprendizaje de los estudiantes en la asignatura Dirección de Operaciones

  19. Picoliter water contact angle measurement on polymers.

    Science.gov (United States)

    Taylor, Michael; Urquhart, Andrew J; Zelzer, Mischa; Davies, Martyn C; Alexander, Morgan R

    2007-06-19

    Water contact angle measurement is the most common method for determining a material's wettability, and the sessile drop approach is the most frequently used. However, the method is generally limited to macroscopic measurements because the base diameter of the droplet is usually greater than 1 mm. Here we report for the first time on a dosing system to dispense smaller individual droplets with control of the position and investigate whether water contact angles determined from picoliter volume water droplets are comparable with those obtained from the conventional microliter volume water droplets. This investigation was conducted on a group of commonly used polymers. To demonstrate the higher spatial resolution of wettability that can be achieved using picoliter volume water droplets, the wettability of a radial plasma polymer gradient was mapped using a 250 microm interval grid.

  20. The Flipped Classroom: Fertile Ground for Nursing Education Research.

    Science.gov (United States)

    Bernard, Jean S

    2015-07-16

    In the flipped classroom (FC) students view pre-recorded lectures or complete pre-class assignments to learn foundational concepts. Class time involves problem-solving and application activities that cultivate higher-level cognitive skills. A systematic, analytical literature review was conducted to explore the FC's current state of the science within higher education. Examination of this model's definition and measures of student performance, student and faculty perceptions revealed an ill-defined educational approach. Few studies confirmed FC effectiveness; many lacked rigorous design, randomized samples, or control of extraneous variables. Few researchers conducted longitudinal studies to determine sufficiently trends related to FC practice. This study proves relevant to nurse educators transitioning from traditional teaching paradigms to learner-centered models, and provides insight from faculty teaching across disciplines around the world. It reveals pertinent findings and identifies current knowledge gaps that call for further inquiry.

  1. Stability of Flip and Exchange Symmetric Entangled State Classes

    Science.gov (United States)

    Zafer Gedik, Mehmet

    2010-03-01

    Flip and exchange symmetric (FES) many-qubit states, which can be obtained from a state with the same symmetries by means of invertible local operations (ILO), constitute a one-parameter family of curves in the Hilbert space. Eigenstates of FES ILOs correspond to vectors that cannot be transformed to other FES states. Therefore, equivalence classes of states under ILO can be determined in a systematic way for an arbitrary number of qubits. More important, for entangled states, at the boundaries of neighboring equivalence classes, one can show that when the fidelity between the final state after an ILO and a state of the neighboring class approaches unity, probability of success decreases to zero. In other words, the classes are stable under ILOs.

  2. Current-type flipped-Γ-source inverters

    DEFF Research Database (Denmark)

    Loh, Poh Chiang; Li, Ding; Blaabjerg, Frede

    2012-01-01

    Z-source inverters are innovative single-stage topologies proposed for flexible buck-boost energy conversion. To raise their gains and modulation ratios further, a number of variations have been introduced with some using magnetically coupled transformers or inductors. These variants are of inter......Z-source inverters are innovative single-stage topologies proposed for flexible buck-boost energy conversion. To raise their gains and modulation ratios further, a number of variations have been introduced with some using magnetically coupled transformers or inductors. These variants...... are of interest since they use lesser components. Their winding turns might however become too excessive for higher demanded gains. Avoiding this usual trend, a new family of current-type flipped-Γ-source inverters are proposed, whose common gain is raised by lowering, and not increasing, the winding turns...

  3. Minimal supersymmetric hybrid inflation, flipped SU(5) and proton decay

    Energy Technology Data Exchange (ETDEWEB)

    Rehman, Mansoor Ur; Shafi, Qaisar [Bartol Research Institute, Department of Physics and Astronomy, University of Delaware, Newark, DE 19716 (United States); Wickman, Joshua R., E-mail: jwickman@udel.ed [Bartol Research Institute, Department of Physics and Astronomy, University of Delaware, Newark, DE 19716 (United States)

    2010-04-26

    Minimal supersymmetric hybrid inflation utilizes a canonical Kaehler potential and a renormalizable superpotential which is uniquely determined by imposing a U(1) R-symmetry. In computing the scalar spectral index n{sub s} we take into account modifications of the tree level potential caused by radiative and supergravity corrections, as well as contributions from the soft supersymmetry breaking terms with a negative soft mass-squared term allowed for the inflaton. All of these contributions play a role in realizing n{sub s} values in the range 0.96-0.97 preferred by WMAP. The U(1) R-symmetry plays an important role in flipped SU(5) by eliminating the troublesome dimension five proton decay. The proton decays into e{sup +}pi{sup 0} via dimension six operators arising from the exchange of superheavy gauge bosons with a lifetime of order 10{sup 34}-10{sup 36} years.

  4. Inverted Classroom an der Hochschule Karlsruhe - ein nicht quantisierter Flip

    CERN Document Server

    Braun, Isabel; Ritter, Stefan; Vasko, Mikko; Voss, Hans-Peter

    2012-01-01

    When does a course count as 'inverted'? When first faced with a new teaching method, deliberate lectures may want to test it without abandoning the advantages of the established method. Aftes the experiment they have to evaluate additional benefits of the new system for teacher and student. Considering the high workload of lecturers, the help of a third party may be useful to obtain an objective assessment of the results during such a transition. At the University of Applied Sciences 'Hochschule Karlsruhe - Technik und Wirtschaft' in Germany, the SKATING project, funded by the German Federal Ministry of Education and Research (BMBF), offers among other things individual technical and didactic advice. This includes practical help with the development, implementation and testing of innovative lecture formats like the Inverted Classroom Method (also known as flipped class). When Professors at the University stated their interest in this approach, varying teaching projects on its implementation and evaluation wer...

  5. Hierarchical neutrino masses and mixing in flipped-SU(5)

    Energy Technology Data Exchange (ETDEWEB)

    Rizos, J. [Physics Department, University of Ioannina, 45110 Ioannina (Greece); Tamvakis, K., E-mail: tamvakis@uoi.g [Physics Department, University of Ioannina, 45110 Ioannina (Greece); Physics Department, CERN, CH-1211, Geneva 23 (Switzerland)

    2010-02-22

    We consider the problem of neutrino masses and mixing in the framework of flipped SU(5). The right-handed neutrino mass, generated through the operation of a seesaw mechanism by a sector of gauge singlets, leads naturally, at a subsequent level, to the standard seesaw mechanism resulting into three light neutrino states with masses of the desired phenomenological order of magnitude. In this framework we study simple Ansaetze for the singlet couplings for which hierarchical neutrino masses emerge naturally as lambda{sup n}:lambda:1 or lambda{sup n}:lambda{sup 2}:1, parametrized in terms of the Cabbibo parameter. The resulting neutrino mixing matrices are characterized by a hierarchical structure, in which theta{sub 13} is always predicted to be the smallest. Finally, we discuss a possible factorized parametrization of the neutrino mass that, in addition to Cabbibo mixing, encodes also mixing due to the singlet sector.

  6. Low-energy lepton violation from supersymmetric flipped SU(5)

    Science.gov (United States)

    Brahm, David E.; Hall, Lawrence J.

    1989-10-01

    We construct a supersymmetric flipped SU(5)⊗U(1) model which violates R parity and electron number at low energies, through a superpotential term (1/2CijkLiLjEck. Rotation of the electron and Higgs superfields makes this term also responsible for charged-lepton masses. The model employs a missing-partners mechanism for the Higgs fields and a seesaw mechanism for the neutrinos. It correctly predicts the approximate electron mass and several mass relations, as well as numerical values for the grand unification scale and the Cijk coefficients. The electron-neutrino Majorana mass is close to experimental limits, and provides constraints. Interesting Z0 decays are predicted: e.g., Z0-->e-μ+e+μ- with invariant-mass peaks in the (e,μ) channels.

  7. Codimension 2 reversible heteroclinic bifurcations with inclination flips

    Institute of Scientific and Technical Information of China (English)

    XU YanCong; ZHU DeMing; DENG GuiFeng

    2009-01-01

    In this paper,the heteroclinic bifurcation problem with real eigenvalues and two inclination-flips is investigated in a four-dimensional reversible system.We perform a detailed study of this case by using the method originally established in the papers "Problems in Homoclinic Bifurcation with Higher Dimensions" and "Bifurcation of Heteroclinic Loops," and obtain fruitful results,such as the existence and coexistence of R-symmetric homoclinic orbit and R-symmetric heteroclinic loops,R-symmetric homoclinic orbit and R-symmetric periodic orbit.The double R-symmetric homoclinic bifurcation (i.e.,two-fold R-symmetric homoclinic bifurcation) for reversible heteroclinic loops is found,and the existence of infinitely many R-symmetric periodic orbits accumulating onto a homoclinic orbit is demonstrated.The relevant bifurcation surfaces and the existence regions are also located.

  8. Computational device design: measuring esophageal distensibility using EndoFLIP

    Science.gov (United States)

    Acharya, Shashank; Kou, Wenjun; Kahrilas, Peter J.; Pandolfino, John E.; Patankar, Neelesh A.

    2016-11-01

    Characterizing the strength of sphincters in the human body is valuable from a diagnostic and surgical standpoint. We develop a numerical model for the EndoFLIP device (Endolumenal Functional Lumen Imaging Probe) that is crucial to the biomechanical study of the Lower Esophageal Sphincter (LES). The simulations demonstrate how the device operates in vivo. From this model, we suggest additional use cases for the device that can give insight into the state of the esophageal wall. Currently, the device measures a single steady quantity (distensibility) that is calculated from pressure and area. Our analysis shows that by capturing and analyzing spatio-temporal pressure variations during peristalsis, the effectiveness of the contractions and health of the surrounding tissue can be quantified. Furthermore, there is an opportunity to validate tissue models by comparing dilation results with clinical data from the device. This work is supported by the Cabell Fellowship at Northwestern Unviersity.

  9. Transmutation Scheme of Coin Flipping Protocol and Utilization

    Institute of Scientific and Technical Information of China (English)

    XIE Yumin; MING Yang; SHI Feng; MUHAMMAD Kamran

    2006-01-01

    Coin flipping by telephone protocol(CFP) is utilized in a system to exchange a binary sequence at random between two person apart far from each other. However, CFP cannot be used in a system with many users like in a group environment system. A transmutation of CFP named T-CFP is proposed in this paper. The precondition of T-CFP is the system's user trusts the system center and center's cheating is meaningless at the same time. The significant difference between CFP and T-CFP is that CFP supports only two users while T-CFP can support many users to exchange special information. The security and efficiency of T-CFP are discussed with a detailed example on T-CFP utilization is demonstrated in this paper.

  10. uFLIP: Understanding the Energy Consumption of Flash Devices

    DEFF Research Database (Denmark)

    Bjørling, Matias; Bonnet, Philippe; Bouganim, Luc

    2010-01-01

    Understanding the energy consumption of flash devices is important for two reasons. First, energy is emerging as a key metric for data management systems. It is thus important to understand how we can reason about the energy consumption of flash devices beyond their approximate aggregate...... consumption (low power consumption in idle mode, average Watt consumption from the data sheets). Second, when measured at a sufficiently fine granularity, the energy consumption of a given device might complement the performance characteristics derived from its response time profile. Indeed, background work...... which is not directly observable with a response time profile appears clearly when energy is used as a metric. In this paper, we discuss the results from the {uFLIP} benchmark applied to four different {SSD} devices using both response time and energy as metric....

  11. Codimension 2 reversible heteroclinic bifurcations with inclination flips

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In this paper, the heteroclinic bifurcation problem with real eigenvalues and two incli- nation-flips is investigated in a four-dimensional reversible system. We perform a detailed study of this case by using the method originally established in the papers "Problems in Homoclinic Bifurcation with Higher Dimensions" and "Bifurcation of Heteroclinic Loops," and obtain fruitful results, such as the existence and coexistence of R-symmetric homoclinic orbit and R-symmetric heteroclinic loops, R-symmetric homoclinic orbit and R-symmetric periodic orbit. The double R-symmetric homoclinic bifurcation (i.e., two-fold R-symmetric homoclinic bifurcation) for reversible heteroclinic loops is found, and the existence of infinitely many R-symmetric periodic orbits accumulating onto a homoclinic orbit is demonstrated. The relevant bifurcation surfaces and the existence regions are also located.

  12. Bifurcations of double homoclinic flip orbits with resonant eigenvalues

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Concerns double homoclinic loops with orbit flips and two resonant eigenvalues in a four-dimensional system. We use the solution of a normal form system to construct a singular map in some neighborhood of the equilibrium, and the solution of a linear variational system to construct a regular map in some neighborhood of the double culation gives explicitly an expression of the associated successor function. By a delicate analysis of the bifurcation equation, we obtain the condition that the original double homoclinic loops are kept, and prove the existence and the existence regions of the large 1-homoclinic orbit bifurcation surface, 2-fold large 1-periodic orbit bifurcation surface,large 2-homoclinic orbit bifurcation surface and their approximate expressions. We also locate the large periodic orbits and large homoclinic orbits and their number.

  13. uFLIP: Understanding the Energy Consumption of Flash Devices

    DEFF Research Database (Denmark)

    Bjørling, Matias; Bonnet, Philippe; Bouganim, Luc

    2010-01-01

    Understanding the energy consumption of flash devices is important for two reasons. First, energy is emerging as a key metric for data management systems. It is thus important to understand how we can reason about the energy consumption of flash devices beyond their approximate aggregate...... consumption (low power consumption in idle mode, average Watt consumption from the data sheets). Second, when measured at a sufficiently fine granularity, the energy consumption of a given device might complement the performance characteristics derived from its response time profile. Indeed, background work...... which is not directly observable with a response time profile appears clearly when energy is used as a metric. In this paper, we discuss the results from the {uFLIP} benchmark applied to four different {SSD} devices using both response time and energy as metric....

  14. FLIPPED CLASSROOM TECHNOLOGY IN DISTANCE AND FULL-TIME TRAINING

    Directory of Open Access Journals (Sweden)

    Oleksandr I. Volnevych

    2013-09-01

    Full Text Available In the present paper there are considered some aspects of the application of new technology of learning process «flipped classroom» formation on the basis of dynamic video lectures in full-time and distance learning. The considered technology is aimed at enhancing the value of students’ independent work, primarily — through creative approach to creation of the lecture material conspectus. Reallocation of learning hours in the direction of increasing time of practical work contributes to the development of students' skills in applying the acquired knowledge. It is presented brief information about the implementation of this technology: definition of screencast, which is actually the base for creation of dynamic video lectures, the main characteristics of the existing software designed for the implementation of training video courses.

  15. Teaching Astronomy using a Flipped Classroom Model of Instruction

    Science.gov (United States)

    Wenger, Matthew; Impey, Chris D.; Rivera Chavez, Wendy

    2014-11-01

    Astronomy: State of the Art is a MOOC specifically developed to study student participation in an online learning environment. The project aims to serve multiple audiences of learners. For this project we focused on college students who use the online environment for lectures and quizzes but whose classroom time is devoted to hands-on activities and group work; this is the “flipped classroom” model.In spring 2014, Astronomy: State of the Art was co-convened with “The Physical Universe,” a Natural Sciences course taught at the University of Arizona that satisfies a General Education requirement for non-science majors. Using the same core material as Astronomy - State of the Art (with additional modules on the physics of radiation, atomic structure, energy, and gravity that are not necessary for the informal learners), the local course employed a “flipped” model where the students access lectures and podcasts online but are in a face-to-face classroom two times a week for labs and hands-on activities, lecture tutorials, group discussions, and other research-validated tools for enhancing learning. A flipped or hybrid model gives students flexibility, uses the online medium for the aspects of instruction where interaction with an instructor isn’t required, and optimizes the scarce resource of time in a large classroom.Final student grades were closely related to their attendance, however, performance in this class was not correlated with completion of the online video lectures, even though the quizzes were closely tied to the content of these videos. The course will next be taught using Coursera which allow instructors to more closely examine the relationship between students use of course materials and understanding of course topics. The eventual goal is to recruit undergraduates from anywhere in the United States and award them transferrable credit for completing the class.

  16. The quadriceps angle

    DEFF Research Database (Denmark)

    Miles, James Edward; Frederiksen, Jane V.; Jensen, Bente Rona

    2012-01-01

    : Pelvic limbs from red foxes (Vulpes vulpes). METHODS: Q angles were measured on hip dysplasia (HD) and whole limb (WL) view radiographs of each limb between the acetabular rim, mid-point (Q1: patellar center, Q2: femoral trochlea), and tibial tuberosity. Errors of 0.5-2.0 mm at measurement landmarks...

  17. Recent advancements of wide-angle polarization analysis with 3He neutron spin filters

    Science.gov (United States)

    Chen, W. C.; Gentile, T. R.; Ye, Q.; Kirchhoff, A.; Watson, S. M.; Rodriguez-Rivera, J. A.; Qiu, Y.; Broholm, C.

    2016-09-01

    Wide-angle polarization analysis with polarized 3He based neutron spin filters (NSFs) has recently been employed on the Multi-Axis Crystal Spectrometer (MACS) at the National Institute of Standards and Technology Center for Neutron Research (NCNR). Over the past several years, the apparatus has undergone many upgrades to address the fundamental requirements for wide angle polarization analysis using spin exchange optical pumping based 3He NSFs. In this paper, we report substantial improvements in the on-beam-line performance of the apparatus and progress toward routine user capability. We discuss new standard samples used for 3He NSF characterization and the flipping ratio measurement on MACS. We further discuss the management of stray magnetic fields produced by operation of superconducting magnets on the MACS instrument, which can significantly reduce the 3He polarization relaxation time. Finally, we present the results of recent development of horseshoe-shaped wide angle cells.

  18. Bigravity from gradient expansion

    Energy Technology Data Exchange (ETDEWEB)

    Yamashita, Yasuho [Yukawa Institute for Theoretical Physics, Kyoto University,606-8502, Kyoto (Japan); Tanaka, Takahiro [Yukawa Institute for Theoretical Physics, Kyoto University,606-8502, Kyoto (Japan); Department of Physics, Kyoto University,606-8502, Kyoto (Japan)

    2016-05-04

    We discuss how the ghost-free bigravity coupled with a single scalar field can be derived from a braneworld setup. We consider DGP two-brane model without radion stabilization. The bulk configuration is solved for given boundary metrics, and it is substituted back into the action to obtain the effective four-dimensional action. In order to obtain the ghost-free bigravity, we consider the gradient expansion in which the brane separation is supposed to be sufficiently small so that two boundary metrics are almost identical. The obtained effective theory is shown to be ghost free as expected, however, the interaction between two gravitons takes the Fierz-Pauli form at the leading order of the gradient expansion, even though we do not use the approximation of linear perturbation. We also find that the radion remains as a scalar field in the four-dimensional effective theory, but its coupling to the metrics is non-trivial.

  19. The flipped classroom for professional development: part II. making podcasts and videos.

    Science.gov (United States)

    Smith, Charlene M; McDonald, Katie

    2013-11-01

    As described in Part I, podcasts and videos are educational technologies used to flip the classroom. This column describes the technology options for creating podcasts and videos and offers tips on developing podcasts and videos.

  20. Do quantum strategies always win? A case study in the entangled quantum penny flip game

    CERN Document Server

    Anand, Namit

    2014-01-01

    In a seminal paper, Meyer\\cite{Meyer} described the advantages of quantum game theory by looking at the classical penny flip game. A player using quantum strategy can win against a classical player almost 100% of the time. Here we make a slight modification of the quantum game in which the two players share an entangled state to begin with. We then analyse two different scenarios one in which the quantum player makes unitary transformations to her qubit while classical player uses a pure strategy of either flipping or not flipping the state of his qubit. In the second scenario we have the quantum player making similar unitary transformations while the classical player makes use of a mixed strategy wherein he either flips or not with some probability "p". We show that in the second scenario 100% win record of a quantum player is drastically reduced and for a particular probability "p" the classical player may even win against the quantum player.

  1. Increasing SLEDed Linac Gradient

    Energy Technology Data Exchange (ETDEWEB)

    Farkas, Zoltan D

    2001-11-08

    This note will show how to increase the SLED [1] gradient by varying Q{sub e}, the external Q of the SLED cavity, by increasing its Q{sub 0} and by increasing the compression ratio. If varying the external Q is to be effective, then the copper losses should be small so that Q{sub 0} >> Q{sub e}. Methods of varying Q{sub e} will be indicated but no experimental data will be presented. If we increase the klystron pulse width from 3.5 to 5 {micro}S and increase Q{sub 0} from the present 100000 to 300000, then the gradient increases by 19% and the beam energy increases from 50 to 60 GeV. This note will also discuss SLED operation at 11424 MHz, the NLC frequency. Without Q{sub e} switching, using SLED at 11424 MHz increases the SLAC gradient from 21 MV/m to 34 MV/m, and at the same repetition rate, uses about 1/5 of rf average power. If we also double the compression ratio, we reach 47 MV/m and over 100 GeV beam energy.

  2. Facing the challenges in ophthalmology clerkship teaching: Is flipped classroom the answer?

    Science.gov (United States)

    Lin, Ying; Zhu, Yi; Chen, Chuan; Wang, Wei; Chen, Tingting; Li, Tao; Li, Yonghao; Liu, Bingqian; Lian, Yu; Lu, Lin; Zou, Yuxian; Liu, Yizhi

    2017-01-01

    Recent reform of medical education highlights the growing concerns about the capability of the current educational model to equip medical school students with essential skills for future career development. In the field of ophthalmology, although many attempts have been made to address the problem of the decreasing teaching time and the increasing load of course content, a growing body of literature indicates the need to reform the current ophthalmology teaching strategies. Flipped classroom is a new pedagogical model in which students develop a basic understanding of the course materials before class, and use in-class time for learner-centered activities, such as group discussion and presentation. However, few studies have evaluated the effectiveness of the flipped classroom in ophthalmology education. This study, for the first time, assesses the use of flipped classroom in ophthalmology, specifically glaucoma and ocular trauma clerkship teaching. A total number of 44 international medical school students from diverse background were enrolled in this study, and randomly divided into two groups. One group took the flipped glaucoma classroom and lecture-based ocular trauma classroom, while the other group took the flipped ocular trauma classroom and lecture-based glaucoma classroom. In the traditional lecture-based classroom, students attended the didactic lecture and did the homework after class. In the flipped classroom, students were asked to watch the prerecorded lectures before the class, and use the class time for homework discussion. Both the teachers and students were asked to complete feedback questionnaires after the classroom. We found that the two groups did not show differences in the final exam scores. However, the flipped classroom helped students to develop skills in problem solving, creative thinking and team working. Also, compared to the lecture-based classroom, both teachers and students were more satisfied with the flipped classroom

  3. Flipping the classroom with team-based learning in undergraduate nursing education.

    Science.gov (United States)

    Della Ratta, Carol B

    2015-01-01

    This article describes the use of team-based learning (TBL) within a flipped classroom setting in an undergraduate nursing course. TBL facilitates active learning through the use of small group, classroom activities. Students used classroom time to solve problems while developing important professional competencies. A preclass PowerPoint lecture with narration, a component of the flipped classroom, was added to address student feedback. Despite mediocre course evaluations, improved student performance on the final course examination was noted.

  4. The efficiency of the "flipped classroom" technology in the lecturers teaching process

    Directory of Open Access Journals (Sweden)

    Nataliya Prykhodkina

    2015-04-01

    Full Text Available The concept of the flipped classroom which is described in the article is based on the ideas of active learning, students' occupation in the general activity, combined learning system, podcast. The flipped classroom is important because the learning time is used for a group study, where the students can discuss the contents of a lecture, check their knowledge and interact with each other practically

  5. Implementation of an optical S-R flip-flop with polarization encoded light signal

    Institute of Scientific and Technical Information of China (English)

    Debajyoti; Samanta; Sourangshu; Mukhopadhyay

    2009-01-01

    A new method is proposed to implement an optical S-R flip-flop by polarization encoded light signal,necessary optical nonlinear material and half-wave plate.In this system the real time speed of operation can be achieved,and at the time of transmission the average power of a byte remains constant.This polarization encoded flip-flop can act as a memory cell.

  6. Quantifying the Impact of Single Bit Flips on Floating Point Arithmetic

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, James J [ORNL; Mueller, Frank [North Carolina State University; Stoyanov, Miroslav K [ORNL; Webster, Clayton G [ORNL

    2013-08-01

    In high-end computing, the collective surface area, smaller fabrication sizes, and increasing density of components have led to an increase in the number of observed bit flips. If mechanisms are not in place to detect them, such flips produce silent errors, i.e. the code returns a result that deviates from the desired solution by more than the allowed tolerance and the discrepancy cannot be distinguished from the standard numerical error associated with the algorithm. These phenomena are believed to occur more frequently in DRAM, but logic gates, arithmetic units, and other circuits are also susceptible to bit flips. Previous work has focused on algorithmic techniques for detecting and correcting bit flips in specific data structures, however, they suffer from lack of generality and often times cannot be implemented in heterogeneous computing environment. Our work takes a novel approach to this problem. We focus on quantifying the impact of a single bit flip on specific floating-point operations. We analyze the error induced by flipping specific bits in the most widely used IEEE floating-point representation in an architecture-agnostic manner, i.e., without requiring proprietary information such as bit flip rates and the vendor-specific circuit designs. We initially study dot products of vectors and demonstrate that not all bit flips create a large error and, more importantly, expected value of the relative magnitude of the error is very sensitive on the bit pattern of the binary representation of the exponent, which strongly depends on scaling. Our results are derived analytically and then verified experimentally with Monte Carlo sampling of random vectors. Furthermore, we consider the natural resilience properties of solvers based on the fixed point iteration and we demonstrate how the resilience of the Jacobi method for linear equations can be significantly improved by rescaling the associated matrix.

  7. Analysis of spin flip data in rings with nearly full Siberian Snakes

    Energy Technology Data Exchange (ETDEWEB)

    Mane, S.R. [Convergent Computing Inc., P.O. Box 561, Shoreham, NY 11786 (United States)], E-mail: srmane@optonline.net

    2009-04-01

    I calculate theoretical values to fit experimental measurements of spin flip resonance widths in rings with nearly full strength Siberian Snakes. Some measurements were made using an rf solenoid, and others using vertical field rf dipoles. In particular, the staff of the MIT-Bates Linear Accelerator Laboratory kindly made available to me additional unpublished data for the spin flipping of stored polarized electrons at 850 MeV using a vertical field rf dipole spin flipper.

  8. Spin-Flip Process through Double Quantum Dots Coupled to Ferromagnetic Leads

    Institute of Scientific and Technical Information of China (English)

    YAN Cong-Hua; WU Shao-Quan; HUANG Rui; SUN Wei-Li

    2006-01-01

    @@ We investigate the spin-flip process through double quantum dots coupled to two ferromagnetic leads in series.By means of the slave-boson mean-field approximation, we calculate the density of states in the Kondo regime for two different configurations of the leads. It is found that transport shows some remarkable properties depending on the spin-flip strength. These effects may be useful in exploiting the role of electronic correlation in spintronics.

  9. All-optical D and T flip-flops based on polarization switch of SOA

    Science.gov (United States)

    Wang, Lina; Wang, Yongjun; Wu, Chen

    2016-11-01

    The semiconductor optical amplifier (SOA) plays an important role in the development of the all-optical signal processing because of the advantages of simple structure, easy integration and strong non-linearity. Especially the nonlinear polarization rotation effect of SOA is receiving considerable interest by many researchers nowadays. The all-optical flip-flop using the properties of SOA also obtains widespread attention by researchers, as all-optical flip-flop is an important part in the field of all-optical signal processing. In this paper, a new all-optical flip-flop structure using polarization switch (PSW) based on polarization rotation effect of SOA is presented. The main work of the paper is the simulation of all-optical logic gates and optical SR latch. The logic gate setup only uses one SOA, but it can get two different logic gates through a simulation. The extinction ratio of the logic gate is about 30dB. The structure of optical SR latch utilizes the two coupled polarization rotation switch of SOA. The structure of the flip-flop is based on these two parts. To demonstrate the feasibility of the structure, we analyze two types of flip-flops, including all-optical D and T flip-flops, whose clock pulse repetition rate is 1GHz with the pulse width of 0.3ns. The quality of all-optical flip-flop in this paper is measured by the falling and rising edge time. In the simulation, the falling edge time is about 50ps, while the rising edge time is higher than the falling edge time, because the gain increases slowly to the recovery time after the decrease of the gain of SOA. The results are useful for the development of all-optical flip-flop based on SOA.

  10. Flips from 4-folds with isolated complete intersection singularities whose downstairs have rational bi-elephants

    CERN Document Server

    Kachi, Y

    1996-01-01

    We shall investigate a flipping contraction g : X -> Y from a 4-fold X with at most isolated complete intersection singularities. If Y has an anti-bi-canonical divisor (=bi-elephant) with only rational singularities, then g carries an inductive structure chained up by blow-ups (La Torre Pendente), and in particular the flip exists. This naturally contains Miles Reid's `Pagoda' as an anti-canonical divisor (=elephant) and its proper transforms.

  11. Implementation of tristate logic based all optical flip-flop with nonlinear material

    Institute of Scientific and Technical Information of China (English)

    Partha Ghosh; Sourangshu Mukhopadhyay

    2005-01-01

    @@ The advantages of multivalued logic in optical parallel computation need no introduction. There are lots of proposals, already reported, where tristate, quarternary state logic operations can be performed with optics. Here we report a new approach to implement tristate logic based all optical flip-flop using optical nonlinear material. The concept and the principle of operation of this type of flip-flop are different from that of the conventional binary one.

  12. Euclidean Geometry Codes, minimum weight words and decodable error-patterns using bit-flipping

    DEFF Research Database (Denmark)

    Høholdt, Tom; Justesen, Jørn; Jonsson, Bergtor

    2005-01-01

    We determine the number of minimum wigth words in a class of Euclidean Geometry codes and link the performance of the bit-flipping decoding algorithm to the geometry of the error patterns.......We determine the number of minimum wigth words in a class of Euclidean Geometry codes and link the performance of the bit-flipping decoding algorithm to the geometry of the error patterns....

  13. Flipped classroom model and its implementation in a computer programming course

    OpenAIRE

    Chen, Eric Zhi

    2014-01-01

    The flipped classroom approach provides implementation of a student-centered learning environment. By changing the traditional classroom lectures and homework elements of a course, it facilitates active learning and higher-order understanding. This paper presents initial experiments on a flipped classroom approach and its application in a programming course. The course results and evaluation show that this approach is rewarding, and why it deserves further investigation.

  14. Effect of Dzyaloshinski-Moriya interaction on elastic small-angle neutron scattering

    Science.gov (United States)

    Michels, Andreas; Mettus, Denis; Honecker, Dirk; Metlov, Konstantin L.

    2016-08-01

    For magnetic materials containing many lattice imperfections (e.g., nanocrystalline magnets), the relativistic Dzyaloshinski-Moriya (DM) interaction may result in nonuniform spin textures due to the lack of inversion symmetry at interfaces. Within the framework of the continuum theory of micromagnetics, we explore the impact of the DM interaction on the elastic magnetic small-angle neutron scattering (SANS) cross section. It is shown that the DM interaction gives rise to a polarization-dependent asymmetric term in the spin-flip SANS cross section. Analysis of this feature may provide a means to determine the DM constant.

  15. Protein adsorption on gradient surfaces on polyethylene prepared in a shielded gas plasma

    NARCIS (Netherlands)

    Spijker, Hendrikje; Bos, Roelof; van Oeveren, Willem; de Vries, Jacob; Busscher, Hendrik

    1999-01-01

    In this study, a new and simple method is described to prepare wettability gradients on polymers by means of glow discharge in a partly shielded argon plasma. The surface characteristics of thus prepared gradients on low density polyethylene were determined by contact angle measurements and electron

  16. Contact angle hysteresis explained.

    Science.gov (United States)

    Gao, Lichao; McCarthy, Thomas J

    2006-07-04

    A view of contact angle hysteresis from the perspectives of the three-phase contact line and of the kinetics of contact line motion is given. Arguments are made that advancing and receding are discrete events that have different activation energies. That hysteresis can be quantified as an activation energy by the changes in interfacial area is argued. That this is an appropriate way of viewing hysteresis is demonstrated with examples.

  17. The lateral angle revisited

    DEFF Research Database (Denmark)

    Morgan, Jeannie; Lynnerup, Niels; Hoppa, R.D.

    2013-01-01

    measurements taken from computed tomography (CT) scans. Previous reports have observed that the lateral angle size in females is significantly larger than in males. The method was applied to an independent series of 77 postmortem CT scans (42 males, 35 females) to validate its accuracy and reliability...... method appears to be of minimal practical use in forensic anthropology and archeology. © 2013 American Academy of Forensic Sciences....

  18. General Review of"Flipped Classroom"%“翻转课堂”面面观

    Institute of Scientific and Technical Information of China (English)

    顾一凡

    2014-01-01

    "Flipped classroom"is catching on in China's primary and secondary schools in recent years, actively advocated by teachers and schools. In accordance with domestic and foreign teaching cases as well as the consensus of flipped classroom re-search experts, the writer elaborated the definition of "flipped classroom",summarized the specific application of"flipped class-room" in teaching practice, and dialectically analyzed the pros and cons of "flipped classroom" and the countermeasures for it, with an attempt to construct a framework for"flipped classroom".%“翻转课堂”近年来风行于我国各中小学,受到教师与学校的热捧。由是,笔者根据国内外教学案例及翻转课堂研究专家的共识,在本文中详细阐明何为“翻转课堂”,概括归纳出“翻转课堂”的具体教学实践运用,辩证分析“翻转课堂”的利弊及出路,试图建构起关于“翻转课堂”的框架。

  19. The Effect of Flipped Learning (Revised Learning on Iranian Students’ Learning Outcomes

    Directory of Open Access Journals (Sweden)

    Asghar Salimi

    2015-10-01

    Full Text Available The purpose of this study was to investigate whether the flipped (revised learning had effect on student learning outcome. Lage et al (2000 describes the flipped classroom as  " Inverting the classroom means that events that have traditionally take place inside the classroom now take place outside the class and vice versa" (p.32. The participants in this study were 250 students and five teachers from a secondary school in Ardabil. Homogenous students were selected on the basis of their scores in the last year.  Ten classes were considered for investigation. There were 25 students in each class and each teacher taught two classes that one of classes was flipped class and another was ordinary class. T-test was used to compare the overall performances of two classes in each subject in order to determine the effect of flipped learning on students’ learning outcomes. The findings of this research demonstrated that there were significant differences between flipped and ordinary classes in students’ learning outcomes. Keywords: flipped class, tradition class, learning outcomes

  20. Acceptability of the flipped classroom approach for in-house teaching in emergency medicine.

    Science.gov (United States)

    Tan, Eunicia; Brainard, Andrew; Larkin, Gregory L

    2015-10-01

    To evaluate the relative acceptability of the flipped classroom approach compared with traditional didactics for in-house teaching in emergency medicine. Our department changed its learning model from a 'standard' lecture-based model to a 'flipped classroom' model. The 'flipped classroom' included provided pre-session learning objectives and resources before each 2 h weekly session. In-session activities emphasised active learning strategies and knowledge application. Feedback was sought from all medical staff regarding the acceptability of the new approach using an online anonymous cross-sectional qualitative survey. Feedback was received from 49/57 (86%) medical staff. Ninety-eight per cent (48/49) of respondents preferred the flipped classroom over the traditional approach. Aspects of the flipped classroom learners liked most included case-based discussion, interaction with peers, application of knowledge, self-directed learning and small-group learning. Barriers to pre-session learning include work commitments, 'life', perceived lack of time, family commitments, exam preparation and high volume of learning materials. Reported motivational factors promoting pre-session learning include formal assessment, participation requirements, more time, less material, more clinical relevance and/or more interesting material. Case studies and 'hands-on' activities were perceived to be the most useful in-session activities. The flipped classroom shows promise as an acceptable approach to in-house emergency medicine teaching. © 2015 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine.