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  1. Optimizing the patient transport function at Mayo Clinic.

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    Kuchera, Dustin; Rohleder, Thomas R

    2011-01-01

    In this article, we report on the implementation of a computerized scheduling tool to optimize staffing for patient transport at the Mayo Clinic. The tool was developed and implemented in Microsoft Excel and Visual Basic for Applications and includes an easy-to-use interface. The tool allows transport management to consider the trade-offs between patient waiting time and staffing levels. While improved staffing efficiency was a desire of the project, it was important that patient service quality was also maintained. The results show that staffing could be reduced while maintaining historical patient service levels.

  2. Case Study: Review of Operating Room Utilization at Mayo Clinic Arizona (MCA)

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    2008-05-01

    offers. The premier programs of the hospital are cancer treatment and solid organ /bone marrow transplant . (Mayo Clinic, 2007) Problem Statement In...improve revenue streams (Overdyl, Harvey, Fishman , & Shippey, 1998). Organizations have seen reduced revenues from operating room care because of lower...TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) RESIDENCY SITE ADDRESS Mayo Clinic Arizona 5777 East Mayo

  3. Current Perspectives on Desmoid Tumors: The Mayo Clinic Approach

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    Scott Okuno

    2011-08-01

    Full Text Available Desmoid tumors are a rare group of locally aggressive, non malignant tumors of fibroblastic origin that can lead to significant morbidity due to local invasion. Despite advances in the understanding of these tumors, their natural history is incompletely understood and the optimal treatment is still a matter of debate. Local control is the main goal of treatment and there has been a change in philosophy regarding the management of these tumors from aggressive surgical resection to function preservation. A multidisciplinary approach is essential to plan local control with acceptable morbidity. The current Mayo Clinic algorithm for the treatment of these tumors is based on institutional experience and the available evidence in the literature: asymptomatic/non progressive lesions away from vital structures are managed with observation and regular imaging; primary or recurrent desmoid tumors which are symptomatic or progressive or near vital structures are managed with wide surgical resection when wide surgical margins are possible with minimal functional and cosmetic loss. When positive or close surgical margins are likely, surgical resection with adjuvant radiotherapy or definitive radiotherapy is preferred. If likely functional or cosmetic deficit is unacceptable, radiotherapy is the treatment of choice. Unresectable lesions are considered for radiotherapy, chemotherapy or newer modalities however an unresectable lesion associated with a painful, functionless, infected extremity is managed with an amputation.

  4. Postradiation sarcoma of bone: review of 78 Mayo Clinic cases

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    Weatherby, R.P.; Dahlin, D.C.; Ivins, J.C.

    1981-05-01

    Postradiation sarcoma of bone is an uncommon but serious sequela of radiation therapy. Seventy-eight Mayo Clinic patients have been treated for sarcomas arising in irradiated bones. They received their initial radiotherapy for a wide variety of nonneoplastic and neoplastic conditions, both benign and malignant. Thirty-five sarcomas arose in bone that was normal at the time of radiotherapy, and 43 arose in irradiated preexisting osseous lesions. The latent period between radiotherapy and diagnosis of sarcoma averaged 14.3 years. Ninety percent of the postradiation sarcomas were either osteosarcomas or fibrosarcomas; chondrosarcoma, malignant (fibrous) histiocytoma, malignant lymphoma, Ewing's tumor, and metastasizing chondroblastoma also occurred. Prompt radical surgery, when feasible, is usually the treatment of choice for the sarcoma. About 30% of patients with sarcomas of the extremities or craniofacial bones survived 5 years without recurrence; there were no disease-free survivors among patients with tumors of the vertebral column, pelvis, or shoulder girdle. The low risk of sarcoma following radiotherapy for the treatment of cancer should not be a contraindication to its use in these patients; however, radiation therapy for benign bone tumors should be reserved for lesions that are not amenable to surgical treatment. An unusual case is also reported herein in which a fibrosarcoma was discovered in the humerus of a patient who had received radiotherapy 55 years previously for a verified osteosarcoma in the same site.

  5. Autoimmune Hemolytic Anemia in Children: Mayo Clinic Experience.

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    Sankaran, Janani; Rodriguez, Vilmarie; Jacob, Eapen K; Kreuter, Justin D; Go, Ronald S

    2016-04-01

    We studied 35 pediatric patients with autoimmune hemolytic anemia seen at Mayo Clinic from 1994 to 2014. The median age was 10.0 years and 65.7% were males. Most had warm antibodies (80.0%) and some secondary to viral (14.3%) or autoimmune disorders (31.4%). Seven (20.0%) patients presented with Evans syndrome, 3 of whom also had common variable immunodeficiency. The median hemoglobin at diagnosis was 6.1 g/dL and 62.8% patients required red cell transfusions. The severity of anemia was worse among children below 10 years (median 5.5 vs. 7.0 g/dL, P=0.01). Steroid was the initial treatment for 88.5% patients, with overall response rate of 82.7% (68.5% complete, 14.2% partial) and median response duration of 10.7 months (range, 0.2 to 129.7+ mo). After median follow-up of 26.6 months, 8 (22.8%) patients relapsed. Salvage treatments included splenectomy, intravenous immunoglobulin, rituximab, and mycophenolate mofetil. Infectious complications occurred in 9 (25.7%) patients and 1 patient died of cytomegalovirus infection. Four patients had cold agglutinin disease and 3 (75.0%) responded to steroids. Autoimmune hemolytic anemia is a rare disorder in pediatric population and most respond well to steroids regardless of the type of antibody. Infectious complications are common and screening for immunodeficiency is recommended among those with Evans syndrome.

  6. Current Perspectives on Desmoid Tumors: The Mayo Clinic Approach

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    Joglekar, Siddharth B. [Musculoskeletal Oncology, Mayo Clinic, Rochester, MN55905 (United States); Rose, Peter S.; Sim, Franklin, E-mail: sim.franklin@mayo.edu [Department of Orthopedics, Mayo Clinic, 200 1st ST SW, Rochester, MN 55905 (United States); Okuno, Scott [Department of Oncology, Mayo Clinic, Rochester, MN55905 (United States); Petersen, Ivy [Department of Radiation Oncology, Mayo Clinic, Rochester, MN55905 (United States)

    2011-08-08

    Desmoid tumors are a rare group of locally aggressive, non malignant tumors of fibroblastic origin that can lead to significant morbidity due to local invasion. Despite advances in the understanding of these tumors, their natural history is incompletely understood and the optimal treatment is still a matter of debate. Local control is the main goal of treatment and there has been a change in philosophy regarding the management of these tumors from aggressive surgical resection to function preservation. A multidisciplinary approach is essential to plan local control with acceptable morbidity. The current Mayo Clinic algorithm for the treatment of these tumors is based on institutional experience and the available evidence in the literature: asymptomatic/non progressive lesions away from vital structures are managed with observation and regular imaging; primary or recurrent desmoid tumors which are symptomatic or progressive or near vital structures are managed with wide surgical resection when wide surgical margins are possible with minimal functional and cosmetic loss. When positive or close surgical margins are likely, surgical resection with adjuvant radiotherapy or definitive radiotherapy is preferred. If likely functional or cosmetic deficit is unacceptable, radiotherapy is the treatment of choice. Unresectable lesions are considered for radiotherapy, chemotherapy or newer modalities however an unresectable lesion associated with a painful, functionless, infected extremity is managed with an amputation.

  7. Twenty years of human immunodeficiency virus care at the Mayo Clinic: Past, present and future

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    Cummins, Nathan W; Badley, Andrew D; Kasten, Mary J; Sampath, Rahul; Temesgen, Zelalem; Whitaker, Jennifer A; Wilson, John W; Yao, Joseph D; Zeuli, John; Rizza, Stacey A

    2016-01-01

    The Mayo human immunodeficiency virus (HIV) Clinic has been providing patient centered care for persons living with HIV in Minnesota and beyond for the past 20 years. Through multidisciplinary engagement, vital clinical outcomes such as retention in care, initiation of antiretroviral therapy and virologic suppression are maximized. In this commentary, we describe the history of the Mayo HIV Clinic and its best practices, providing a “Mayo Model” of HIV care that exceeds national outcomes and may be applicable in other settings. PMID:27175350

  8. The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data.

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    Chute, Christopher G; Beck, Scott A; Fisk, Thomas B; Mohr, David N

    2010-01-01

    Mayo Clinic's Enterprise Data Trust is a collection of data from patient care, education, research, and administrative transactional systems, organized to support information retrieval, business intelligence, and high-level decision making. Structurally it is a top-down, subject-oriented, integrated, time-variant, and non-volatile collection of data in support of Mayo Clinic's analytic and decision-making processes. It is an interconnected piece of Mayo Clinic's Enterprise Information Management initiative, which also includes Data Governance, Enterprise Data Modeling, the Enterprise Vocabulary System, and Metadata Management. These resources enable unprecedented organization of enterprise information about patient, genomic, and research data. While facile access for cohort definition or aggregate retrieval is supported, a high level of security, retrieval audit, and user authentication ensures privacy, confidentiality, and respect for the trust imparted by our patients for the respectful use of information about their conditions.

  9. The Enterprise Data Trust at Mayo Clinic: a semantically integrated warehouse of biomedical data

    Science.gov (United States)

    Beck, Scott A; Fisk, Thomas B; Mohr, David N

    2010-01-01

    Mayo Clinic's Enterprise Data Trust is a collection of data from patient care, education, research, and administrative transactional systems, organized to support information retrieval, business intelligence, and high-level decision making. Structurally it is a top-down, subject-oriented, integrated, time-variant, and non-volatile collection of data in support of Mayo Clinic's analytic and decision-making processes. It is an interconnected piece of Mayo Clinic's Enterprise Information Management initiative, which also includes Data Governance, Enterprise Data Modeling, the Enterprise Vocabulary System, and Metadata Management. These resources enable unprecedented organization of enterprise information about patient, genomic, and research data. While facile access for cohort definition or aggregate retrieval is supported, a high level of security, retrieval audit, and user authentication ensures privacy, confidentiality, and respect for the trust imparted by our patients for the respectful use of information about their conditions. PMID:20190054

  10. Management of Endometrial Cancer at Mayo Clinic: Intensive Surgical Staging and Disease-based Postoperative Treatment

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    Mariani, A.

    2006-01-01

    Chapter 1 is a general introduction, while chapter 8 is the final discussion and conclusions. The remaining chapters (from 2 to 7) are composed by a brief introduction, followed by the published article(s) that form(s) the structure of the chapter. Management of Endometrial Cancer at Mayo Clinic: I

  11. Management of Endometrial Cancer at Mayo Clinic: Intensive Surgical Staging and Disease-based Postoperative Treatment

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    Mariani, A.

    2006-01-01

    Chapter 1 is a general introduction, while chapter 8 is the final discussion and conclusions. The remaining chapters (from 2 to 7) are composed by a brief introduction, followed by the published article(s) that form(s) the structure of the chapter. Management of Endometrial Cancer at Mayo Clinic: I

  12. Fecal microbiota transplant for recurrent Clostridium difficile infection: Mayo Clinic in Arizona experience.

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    Patel, Neal C; Griesbach, Cheryl L; DiBaise, John K; Orenstein, Robert

    2013-08-01

    To report the initial experience of treating recurrent Clostridium difficile infection (CDI) with fecal microbiota transplant (FMT) at Mayo Clinic in Arizona. The study retrospectively reviewed FMTs performed at Mayo Clinic in Arizona between January 1, 2011, and January 31, 2013. All the recipients had multiple recurrent CDIs unresponsive to traditional antibiotic drug therapy. A standardized protocol was developed to identify patients, screen donors, perform FMT, and determine outcomes via telephone surveys. Thirty-one patients (mean ± SD age, 61.26±19.34 years) underwent FMT. Median time from index infection to FMT was 340 days. Ninety-seven percent (29 of 30) of patients reported substantial improvement or resolution of diarrhea (median time to improvement, 3 days), 74% (17 of 23) reported improvement or resolution of abdominal pain (median time to improvement, 3 days), and 55% (16 of 29) had improvement or resolution of fatigue (median time to improvement, 6 days). Three patients underwent repeated FMT owing to persistent symptoms; 2 reported improvement in diarrhea with the second therapy. No serious adverse events directly related to FMT were reported. A standardized regimen of FMT for recurrent CDI is safe, is highly effective, and can be provided using a relatively simple protocol. Copyright © 2013 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  13. Patient quality of life in the Mayo Clinic Care Transitions program: a survey study

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    Faucher J

    2016-08-01

    Full Text Available Joshua Faucher,1 Jordan Rosedahl,2 Dawn Finnie,3 Amy Glasgow,3 Paul Takahashi4 1Mayo Medical School, Mayo Clinic College of Medicine, 2Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, 3Center for the Science of Health Care Delivery, 4Division of Primary Care Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN, USA Background: Transitional care programs are common interventions aimed at reducing medical complications and associated readmissions for patients recently discharged from the hospital. While organizations strive to reduce readmissions, another important related metric is patient quality of life (QoL. Aims: To compare the relationship between QoL in patients enrolled in the Mayo Clinic Care Transitions (MCCT program versus usual care, and to determine if QoL changed in MCCT participants between baseline and 1-year follow-up. Methods: A baseline survey was mailed to MCCT enrollees in March 2013. Those who completed a baseline survey were sent a follow-up survey 1 year later. A cross-sectional survey of usual care participants was mailed in November 2013. We included in our analysis 199 participants (83 in the MCCT and 116 in usual care aged over 60 years with multiple comorbidities and receiving primary care. Primary outcomes were self-rated QoL; secondary outcomes included self-reported general, physical, and mental health. Intra- and intergroup comparisons of patients were evaluated using Pearson’s chi-squared analysis. Results: MCCT participants had more comorbidities and higher elder risk assessment scores than those receiving usual care. At baseline, 74% of MCCT participants reported responses of good-to-excellent QoL compared to 64% after 1 year (P=0.16. Between MCCT and usual care, there was no significant difference in self-reported QoL (P=0.21. Between baseline and follow-up in MCCT patients, and compared to usual care, there were no significant

  14. Clinical diagnostic testing for the cytogenetic and molecular causes of male infertility: the Mayo Clinic experience.

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    Hofherr, Sean E; Wiktor, Anne E; Kipp, Benjamin R; Dawson, D Brian; Van Dyke, Daniel L

    2011-11-01

    Approximately 8% of couples attempting to conceive are infertile and male infertility accounts for approximately 50% of infertility among couples. Up to 25% of males with non-obstructive infertility have chromosomal abnormalities and/or microdeletions of the long arm of the Y-chromosome. These are detected by conventional chromosome and Y-microdeletion analysis. In this study, we reviewed the results of testing performed in the Mayo Clinic Cytogenetics and Molecular Genetics Laboratories and compared our findings with previously published reports. This study includes 2,242 chromosome studies from males ≥18 years of age referred for infertility between 1989 and 2000 and 2,749 Y-deletion molecular studies performed between 2002 and 2009. 14.3% of infertile males tested by karyotyping had abnormalities identified. These include: (258) 47,XXY and variants consistent with Klinefelter syndrome, (3) combined 47,XXY and balanced autosomal rearrangements, (9) 47,XYY, (9) Y-deletions, (7) 46,XX males, (32) balanced rearrangements, and (1) unbalanced rearrangement. 3.6% of males tested for Y-microdeletion analysis had abnormalities identified, 90% of which included a deletion of the AZFc region. This study highlights the need of males suffering from non-obstructive infertility to have laboratory genetic testing performed. An abnormal finding can have significant consequences to assisted reproductive techniques and fertility treatment, and provide a firm diagnosis to couples with longstanding infertility.

  15. Building a protocol expressway: the case of Mayo Clinic Cancer Center.

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    McJoynt, Terre A; Hirzallah, Muhanad A; Satele, Daniel V; Pitzen, Jason H; Alberts, Steven R; Rajkumar, S Vincent

    2009-08-10

    Inconsistencies and errors resulting from nonstandard processes, together with redundancies, rework, and excess workload, lead to extended time frames for clinical trial protocol development. This results in dissatisfaction among sponsors, investigators, and staff and restricts the availability of novel treatment options for patients. A team of experts from Mayo Clinic formed, including Protocol Development Unit staff and management from the three Mayo Clinic campuses (Florida, Minnesota, and Arizona), a systems and procedures analyst, a quality office analyst, and two physician members to address the identified deficiencies. The current-state process was intensively reviewed, and improvement steps were taken to accelerate the development and approval of cancer-related clinical trials. The primary goal was to decrease the time from receipt of a new protocol through submission to an approving authority, such as the National Cancer Institute or institutional review board. Using the Define, Measure, Analyze, Improve, Control (DMAIC) framework infused with Lean waste-reduction methodologies, areas were identified for improvement, including enhancing first-time quality and processing new studies on a first-in/first-out basis. The project was successful in improving the mean turnaround time for internally authored protocols (P Lean methodologies is an effective tool to structure the definition, planning, analysis, and implementation of significant process changes.

  16. Bringing human resources to the table: utilization of an HR balanced scorecard at Mayo Clinic.

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    Fottler, Myron D; Erickson, Eric; Rivers, Patrick A

    2006-01-01

    Rather than viewing HR as a critical driver of organizational strategy and outcomes, most health care organizations see HR as a drain on the organization's bottom line. Only by aligning HR with the organizational strategy will HR leaders truly get a seat at the leadership table. HR professionals can overcome impediments and gain a seat at the table by learning the language of business and the ways in which organizational leaders use data to drive their decisions. This article shows how Mayo Clinic uses the popular Balanced Scorecard approach to align its measures of HR performance to the organization's strategic plan.

  17. Physician-Organization Collaboration Reduces Physician Burnout and Promotes Engagement: The Mayo Clinic Experience.

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    Swensen, Stephen; Kabcenell, Andrea; Shanafelt, Tait

    2016-01-01

    The process of creating healthy organization-physician relationships is critical to organizational success. Partnerships in process improvement can nurture these relationships and mitigate burnout by meeting physicians' psychological needs. To flourish, physicians need some degree of choice (control over their lives), camaraderie (social connectedness), and an opportunity for excellence (being part of something meaningful). Organizations can provide these opportunities by establishing constructive organization-physician relationships and developing physician leaders. We present a case study from the Mayo Clinic that supports the foundational principles of a physician-engagement model. We developed the Listen-Act-Develop model as an integrated strategy to reduce burnout and engage physicians in the mission of the organization. The intent of the model is to maximize physician wellness by fostering engagement and mitigating the drivers of burnout. This model provides a path to increase physician satisfaction and meaning in work and to improve organizational effectiveness.

  18. Children Thyroid Cancer treatment in Saint-Petersburg Endocrine SurgeryCenter and Mayo Clinic

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    Aleksandr Filippovich Romanchishen

    2015-02-01

    Full Text Available IntroductionThyroid cancer (TC is the most often malignant tumor in childhood and made 1.5 – 3.0% of all children population or 45.3% of pediatric endocrine epithelial cancers. A lot of questions concerning to volume of thyroid surgery, postoperative radio iodine therapy (RIT needs to be discussed.AimEstimation of childhood sporadic thyroid cancer specificity and comparison of children and adolescents treatment in Saint-Petersburg Endocrine Surgery Center (Russia and Mayo Clinic (USA.Material and methodsDuring 1970 –2011 in the Saint-Petersburg Center (1 group were operated 105 TC children and adolescent (up to 20 yeas and in Mayo Clinic – 188 (2 group in  1940 – 2000 period. Since of 80-s in those clinics were used the same perioperative examinations, like TSH, T4, T3 blood levels, USG, fine needles aspiration biopsy, CT and morphological examinations.Results and discussionAverage age of the Saint-Petersburg Center and Rochester patients was the same and achieve 16.3±0.3 and 16.0±0.5, accordingly. In both groups has prevailed girls: in the 1 group they made 73.3% (M:F 1:2.7 and in the 2 – 70.7% (M:F 1:2.4. Childhood differentiated TC were associated with aggressive behavior: regional metastases were found in 53.0% and 81.4%, extrathyroid TC spreading – in 9.6 and 19.7%, distant metastases - in 9.6 and 4.8%, accordingly. In our Center (1 group we have performed hemithyroidectomies and subtotal Thyroidectomies in 58.1% with ipsilateral central neck dissection (CND. In Mayo Clinic in all TC cases were performed thyroidectomy (TE since 1950. TC relapses we have no   observed in 1 group and they have place in 6.9% 2 group patients, recurring lymphatic metastases – in 8.4% and 20.7%, accordingly. Radioiodine therapy (RIT has performed in 21.1% and 25.5% operated children.In 1 group 95 (96.0 % of 99 operated were alive during 5 – 36 years, in the 2– only in two cases reason of death was TC, but in 14 – other malignant tumor

  19. Long-term outcome of patients with POEMS syndrome: An update of the Mayo Clinic experience.

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    Kourelis, Taxiarchis V; Buadi, Francis K; Kumar, Shaji K; Gertz, Morie A; Lacy, Martha Q; Dingli, David; Go, Ronald S; Kapoor, Prashant; Lust, John A; Hayman, Suzanne R; Hwa, Yi; Rajkumar, S Vincent; Zeldenrust, Steven R; Russell, Stephen J; Lin, Yi; Leung, Nelson; Kyle, Robert A; Gonsalves, Wilson I; Dispenzieri, Angela

    2016-06-01

    Over the past decade, a number of changes have occurred in the diagnostic evaluation, management, and long-term follow-up of patients with POEMS syndrome at our institution. This study included 291 patients with POEMS syndrome diagnosed at the Mayo Clinic between 1974 and 2014. Patients diagnosed after 2003 had more features of the syndrome identified at diagnosis and were more likely to receive an autologous transplant (49% versus 8%, P complete response (CR) to treatment (41% vs 25%, P C.I., 56%, 67%). On multivariate analysis, the three factors associated with superior OS were younger age (RR 0.98 [0.96-1.00]), albumin greater-than 3.2 g/dL (RR 0.5 [0.32-0.89]) and attainment of complete hematologic response (RR 0.4 [0.2, 0.9]). This study confirms the very good long-term outcomes of patients with POEMS syndrome and identifies two new prognostic risk factors: albumin at diagnosis and attainment of complete hematologic response. Am. J. Hematol. 91:585-589, 2016. © 2016 Wiley Periodicals, Inc.

  20. Eluation of adjuvant chemoradiation therapy for ampullary adenocarcinoma: the Johns Hopkins Hospital - Mayo Clinic collaborative study

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    Zhou Jessica

    2011-09-01

    Full Text Available Abstract Background The role of adjuvant chemoradiation therapy for ampullary carcinoma is unknown. Previous literature suggests that certain populations with high risk factors for recurrence may benefit from adjuvant chemoradiation. We combined the experience of two institutions to better delineate which patients may benefit from adjuvant chemoradiation. Methods Patients who underwent curative surgery for ampullary carcinoma at the Johns Hopkins Hospital (n = 290; 1992-2007 and at the Mayo Clinic (n = 130; 1977-2005 were reviewed. Patients with Results Median overall-survival was 39.9 months with 2- and 5-year survival rates of 62.4% and 39.1%. On univariate analysis, adverse prognostic factors for overall survival included T3/T4 stage disease (RR = 1.86, p = 0.002, node positive status (RR = 3.18, p Conclusions Node-positive patients with resected ampullary adenocarcinoma may benefit from 5-FU based adjuvant chemoradiation. Since a significant proportion of patients develop metastatic disease, there is a need for more effective systemic treatment.

  1. Delusional infestation is typically comorbid with other psychiatric diagnoses: review of 54 patients receiving psychiatric evaluation at Mayo Clinic.

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    Hylwa, Sara A; Foster, Ashley A; Bury, Jessica E; Davis, Mark D P; Pittelkow, Mark R; Bostwick, J Michael

    2012-01-01

    Delusional infestation, which encompasses both delusions of parasitosis and delusions of infestation with inanimate objects (sometimes called Morgellons disease), has been said to represent a distinct and encapsulated delusion, that is, a stand-alone diagnosis. Anecdotally, we have observed that patients with delusional infestation often have one or more psychiatric comorbid conditions and that delusional infestation should not be regarded as a stand-alone diagnosis. The purpose of this study was to identify whether patients with delusional infestation have psychiatric comorbid conditions. We therefore identified patients who had been formally evaluated in the Department of Psychiatry during their visit to Mayo Clinic. We retrospectively searched for and reviewed the cases of all patients with delusional infestation seen from 2001 through 2007 at Mayo Clinic, Rochester, Minnesota, and who underwent psychiatric evaluation. The diagnoses resulting from psychiatric evaluation were analyzed. During the 7-year study period, 109 patients seen for delusional infestation at Mayo Clinic were referred to the Department of Psychiatry, 54 (50%) of whom actually followed through with psychiatric consultation. Of these 54 patients, 40 (74%) received additional active psychiatric diagnoses; 14 patients (26%) had delusional infestation alone. Abnormal personality traits were rarely documented. Most patients with delusional infestation have multiple coexisting or underlying psychiatric disorders. Therefore, evaluation by a psychiatrist, when possible, is advised for all patients with delusional infestation. Copyright © 2012 The Academy of Psychosomatic Medicine. Published by Elsevier Inc. All rights reserved.

  2. Complex fibroadenoma and breast cancer risk: a Mayo Clinic Benign Breast Disease Cohort Study.

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    Nassar, Aziza; Visscher, Daniel W; Degnim, Amy C; Frank, Ryan D; Vierkant, Robert A; Frost, Marlene; Radisky, Derek C; Vachon, Celine M; Kraft, Ruth A; Hartmann, Lynn C; Ghosh, Karthik

    2015-09-01

    The purpose of this study is to examine the breast cancer risk overall among women with simple fibroadenoma or complex fibroadenoma and to examine the association of complex fibroadenoma with breast cancer through stratification of other breast cancer risks. The study included women aged 18-85 years from the Mayo Clinic Benign Breast Disease Cohort who underwent excisional breast biopsy from 1967 through 1991. Within this cohort, women who had fibroadenoma were compared to women who did not have fibroadenoma. Breast cancer risk (observed versus expected) across fibroadenoma levels was assessed through standardized incidence ratios (SIRs) by using age- and calendar-stratified incidence rates from the Iowa Surveillance, Epidemiology, and End Results registry. Analyses were performed overall, within subgroups of involution status, with other demographic characteristics (age, year of biopsy, indication for biopsy, and family history), and with histologic characteristics, including overall impression [nonproliferative disease, proliferative disease without atypia (PDWA), or atypical hyperplasia]. Fibroadenoma was identified in 2136 women [noncomplex, 1835 (85.9%); complex, 301 (14.1%)]. SIR for noncomplex fibroadenoma was 1.49 (95% CI 1.26-1.74); for complex fibroadenoma, it was 2.27 (95% CI 1.63-3.10) (test for heterogeneity in SIR, P = .02). However, women with complex fibroadenoma were more likely to have other, concomitant high-risk histologic characteristics (e.g., incomplete involution and PDWA). In analyses stratified by involution status and PDWA, complex fibroadenoma was not an independent risk marker for breast cancer. Complex fibroadenoma does not confer increased breast cancer risk beyond other established histologic characteristics.

  3. Syndrome of rapid onset end stage renal disease in incident Mayo Clinic chronic hemodialysis patient

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    M. A. C. Onuigbo

    2014-01-01

    Full Text Available Despite decades of research, a full understanding of chronic kidney disease (CKD-end stage renal disease (ESRD progression remains elusive. The common consensus is a predictable, linear, progressive and time-dependent decline of CKD to ESRD. Acute kidney injury (AKI on CKD is usually assumed to be transient, with recovery as the expected outcome. AKI-ESRD association in current nephrology literature is blamed on the so-called "residual confounding." We had previously described a relationship between AKI events and rapid onset yet irreversible ESRD happening in a continuum in a high-risk CKD cohort. However, the contribution of the syndrome of rapid onset-ESRD (SORO-ESRD to incident United States ESRD population remained conjectural. In this retrospective analysis, we analyzed serum creatinine trajectories of the last 100 consecutive ESRD patients in 4 Mayo Clinic chronic hemodialysis units to determine the incidence of SORO-ESRD. Excluding 9 patients, 31 (34% patients, including two renal transplant recipients, had SORO-ESRD: 18 males and 13 females age 72 (range 50-92 years. Precipitating AKI followed pneumonia (8, acutely decompensated heart failure (7, pyelonephritis (4, post-operative (5, sepsis (3, contrast-induced nephropathy (2, and others (2. Time to dialysis was shortest following surgical procedures. Concurrent renin angiotensin aldosterone system blockade was higher with SORO-ESRD - 23% versus 5%, P = 0.0113. In conclusion, SORO-ESRD is not uncommon among the incident general US ESRD population. The implications for ESRD care planning, AV-fistula-first programs, general CKD care and any associations with renal ageing/senescence warrant further study.

  4. Long-term outcomes of radiotherapy for stage II testicular seminoma--the Mayo Clinic experience.

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    Hallemeier, Christopher L; Pisansky, Thomas M; Davis, Brian J; Choo, Richard

    2013-11-01

    To report long-term outcomes of patients with stage II testicular seminoma treated with radiotherapy (RT). A retrospective review was performed of 52 patients who received megavoltage RT for stage II testicular seminoma at Mayo Clinic between 1974 and 2007. Forty-eight patients (92%) had computed tomography staging. Overall survival (OS), relapse-free survival (RFS), and cause-specific survival (CSS) were determined using the Kaplan-Meier method. Major cardiac event (MCE) was defined as myocardial infarction, coronary artery bypass grafting or stenting, or valve replacement. Second malignancy (SM) was defined as biopsy-confirmed malignancy occurring in the RT field. The median patient age at diagnosis was 36 years. Stage was IIA (n = 24), IIB (n = 7), IIC (n = 17), and II not otherwise specified (NOS, n = 4). The median infradiaphragmatic RT dose was 30.7 Gy. Twenty-six patients (50%) received prophylactic mediastinal/supraclavicular (MSCV) RT. The median follow-up was 19 years. Estimates of OS, RFS, and CSS were 94%, 80%, and 96% at 10 years, and 83%, 72%, and 96% at 20 years, respectively. RFS at 10 years for stage IIA, IIB, IIC, and II NOS were 83%, 54%, 81%, and 100%, respectively (log-rank P = 0.21). Ten patients (19%) experienced disease relapse in the MSCV region (n = 7), para-aortic lymph nodes (n = 1), lung (n = 1), or peritoneal cavity (n = 1). Eight patients were successfully salvaged with chemotherapy and/or surgery, while 2 died of seminoma. Risk of MSCV relapse was significantly lower in patients who received MSCV RT vs. those who did not (10-year estimates: 4% vs. 21%, respectively, log-rank P = 0.01). MCE occurred in 10 patients (19%) at a median of 18 years (range 7-30) after RT. SM occurred in 5 patients (10%) at a median of 27 years (range 20-34) after RT. In patients with stage II testicular seminoma treated with RT, relapse in the irradiated site was uncommon. Infradiaphragmatic RT alone was associated with a significant risk of MSCV failure

  5. Patient quality of life in the Mayo Clinic Care Transitions program: a survey study

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    Faucher, Joshua; Rosedahl, Jordan; Finnie, Dawn; Glasgow, Amy; Takahashi, Paul

    2016-01-01

    Background Transitional care programs are common interventions aimed at reducing medical complications and associated readmissions for patients recently discharged from the hospital. While organizations strive to reduce readmissions, another important related metric is patient quality of life (QoL). Aims To compare the relationship between QoL in patients enrolled in the Mayo Clinic Care Transitions (MCCT) program versus usual care, and to determine if QoL changed in MCCT participants between baseline and 1-year follow-up. Methods A baseline survey was mailed to MCCT enrollees in March 2013. Those who completed a baseline survey were sent a follow-up survey 1 year later. A cross-sectional survey of usual care participants was mailed in November 2013. We included in our analysis 199 participants (83 in the MCCT and 116 in usual care) aged over 60 years with multiple comorbidities and receiving primary care. Primary outcomes were self-rated QoL; secondary outcomes included self-reported general, physical, and mental health. Intra- and intergroup comparisons of patients were evaluated using Pearson’s chi-squared analysis. Results MCCT participants had more comorbidities and higher elder risk assessment scores than those receiving usual care. At baseline, 74% of MCCT participants reported responses of good-to-excellent QoL compared to 64% after 1 year (P=0.16). Between MCCT and usual care, there was no significant difference in self-reported QoL (P=0.21). Between baseline and follow-up in MCCT patients, and compared to usual care, there were no significant differences in self-reported general, physical, or mental health. Conclusion We detected no difference over time in QoL between MCCT patients and those receiving usual care, and a nonsignificant QoL decline in MCCT participants after 1 year. Progression of chronic disease may overwhelm any QoL improvement attributable to the MCCT intervention. The MCCT interventions may blunt expected declines in QoL, producing

  6. Long term outcomes of cardiac transplant for immunoglobulin light chain amyloidosis: The Mayo Clinic experience

    Science.gov (United States)

    Grogan, Martha; Gertz, Morie; McCurdy, Arleigh; Roeker, Lindsey; Kyle, Robert; Kushwaha, Sudhir; Daly, Richard; Dearani, Joseph; Rodeheffer, Richard; Frantz, Robert; Lacy, Martha; Hayman, Suzanne; McGregor, Christopher; Edwards, Brooks; Dispenzieri, Angela

    2016-01-01

    AIM: To determine the outcome of orthotopic heart transplantation (OHT) in immunoglobulin light chain (AL) amyloidosis. METHODS: The medical records of patients with AL who underwent orthotopic heart transplantation at the Mayo Clinic in Rochester Minnesota from 1992 to 2011 were reviewed. Patients met at least one of the following at: New York Heart Association class IV heart failure, ventricular thickness > 15 mm, ejection fraction < 40%. Selection guidelines for heart transplant included age < 60 years, absence of multiple myeloma and significant extra-cardiac organ involvement. Baseline characteristics including age, gender, organ involvement, and New York Heart Association functional class were recorded. Laboratory data, waiting time until heart transplant, and type of treatment of the underlying plasma cell disorder were recorded. Survival from the time of OHT was calculated using Kaplan-Meier survival curves. Survival of patients undergoing OHT for AL was compared to that of non-amyloid patients undergoing OHT during the same time period. RESULTS: Twenty-three patients (median age 53 years) with AL received OHT. There were no deaths in the immediate perioperative period. Twenty patients have died post OHT. For the entire cohort, the median overall survival was 3.5 years (95%CI: 1.2, 8.2 years). The 1-year survival post OHT was 77%, the 2-year survival 65%, and the 5-year survival 43%. The 5-year survival for non-amyloid patients undergoing OHT during the same era was 85%. Progressive amyloidosis contributed to death in twelve patients. Of those without evidence of progressive amyloidosis, the cause of death included complications of autologous hematopoietic stem cell transplantation for 3 patients, post-transplant lymphoproliferative disorder for 2 patients; and for the remaining one death was related to each of the following causes: acute rejection; cardiac vasculopathy; metastatic melanoma; myelodysplastic syndrome; and unknown. Eight patients had

  7. What makes a Catholic hospital "Catholic" in an age of religious-secular collaboration? The case of the Saint Marys hospital and the Mayo Clinic.

    Science.gov (United States)

    Swetz, Keith M; Crowley, Mary E; Maines, T Dean

    2013-06-01

    Mayo Clinic is recognized as a worldwide leader in innovative, high-quality health care. However, the Catholic mission and ideals from which this organization was formed are not widely recognized or known. From partnership with the Sisters of St. Francis in 1883, through restructuring of the Sponsorship Agreement in 1986 and current advancements, this Catholic mission remains vital today at Saint Marys Hospital. This manuscript explores the evolution and growth of sponsorship at Mayo Clinic, defined as "a collaboration between the Sisters of St. Francis and Mayo Clinic to preserve and promote key values that the founding Franciscan sisters and Mayo physicians embrace as basic to their mission, and to assure the Catholic identity of Saint Marys Hospital." Historical context will be used to frame the evolution and preservation of Catholic identity at Saint Marys Hospital; and the shift from a "sponsorship-by-governance" to a "sponsorship-by-influence" model will be highlighted. Lastly, using the externally-developed Catholic Identity Matrix (developed by Ascension Health and the University of St. Thomas, Minnesota), specific examples of Catholic identity will be explored in this joint venture of Catholic health care institution and a secular, nonprofit corporation (Mayo Clinic).

  8. Harmonizing and consolidating the measurement of patient-reported information at health care institutions: a position statement of the Mayo Clinic

    Directory of Open Access Journals (Sweden)

    Eton DT

    2014-02-01

    Full Text Available David T Eton,1,2 Timothy J Beebe,1,2 Philip T Hagen,3 Michele Y Halyard,4 Victor M Montori,1,5 James M Naessens,1,2 Jeff A Sloan,6 Carrie A Thompson,7 Douglas L Wood1,81Division of Heath Care Policy and Research, Department of Health Sciences Research, 2Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, 3Department of Preventive, Occupational, and Aerospace Medicine, Mayo Clinic, Rochester, MN, 4Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, 5Knowledge and Evaluation Research Unit, 6Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, 7Division of Hematology, Department of Medicine, 8Center for Innovation, Mayo Clinic, Rochester, MN, USAAbstract: Patient-reported outcomes (PROs capture how patients perceive their health and their health care; their use in clinical research is longstanding. Today, however, PROs increasingly are being used to inform the care of individual patients, and document the performance of health care entities. We recently wrote and internally distributed an institutional position statement titled "Harmonizing and Consolidating the Measurement of Patient-Reported Outcomes at Mayo Clinic: A Position Statement for the Center for the Science of Health Care Delivery". The statement is meant to educate clinicians, clinical teams, and institutional administrators about the merits of using PROs in a systematic manner for clinical care and quality measurement throughout the institution. The present article summarizes the most important messages from the statement, describing PROs and their use, identifying practical considerations for implementing them in routine practice, elucidating potential barriers to their use, and formulating strategies to overcome these barriers. The lessons learned from our experience – including pitfalls, challenges, and successes – may inform other health care institutions that are interested in

  9. How well do whole exome sequencing results correlate with medical findings? A study of 89 Mayo Clinic Biobank samples

    Directory of Open Access Journals (Sweden)

    Sumit eMiddha

    2015-07-01

    Full Text Available Whole Exome Sequencing (WES is increasingly being used for diagnosis without adequate information on predictive characteristics of reportable variants typically found on any given individual and correlation with clinical phenotype. In this study, we performed WES on 89 deceased individuals (mean age at death 74 years, range 28-93 from the Mayo Clinic Biobank. Significant clinical diagnoses were abstracted from electronic-medical-record via chart review. Variants (Single Nucleotide Variant and insertion/deletion were filtered based on quality (accuracy >99%, read-depth >20, alternate-allele read-depth >5, minor-allele-frequency 0.19. Evaluating genotype-phenotype correlations across the exome, 202 (3% of 7046 filtered variants had some evidence for phenotypic correlation in medical-records, while 3710 (53% variants had no phenotypic correlation. The phenotype associated with the remaining 44% could not be assessed from a typical medical record review. These data highlight significant continued challenges in the ability to extract medically meaningful predictive results from WES.

  10. Early experience of a fall and fracture prevention clinic at Mayo General Hospital.

    LENUS (Irish Health Repository)

    Hanley, A

    2010-06-01

    Falls in the elderly are a significant public health problem. Previous studies have shown that most falls are multifactorial and an efficacious way of reducing the risk of falling is provided by a falls clinic.

  11. Thrombotic Microangiopathy Care Pathway: A Consensus Statement for the Mayo Clinic Complement Alternative Pathway-Thrombotic Microangiopathy (CAP-TMA) Disease-Oriented Group.

    Science.gov (United States)

    Go, Ronald S; Winters, Jeffrey L; Leung, Nelson; Murray, David L; Willrich, Maria A; Abraham, Roshini S; Amer, Hatem; Hogan, William J; Marshall, Ariela L; Sethi, Sanjeev; Tran, Cheryl L; Chen, Dong; Pruthi, Rajiv K; Ashrani, Aneel A; Fervenza, Fernando C; Cramer, Carl H; Rodriguez, Vilmarie; Wolanskyj, Alexandra P; Thomé, Stephan D; Hook, C Christopher

    2016-09-01

    Thrombotic microangiopathies (TMAs) comprise a heterogeneous set of conditions linked by a common histopathologic finding of endothelial damage resulting in microvascular thromboses and potentially serious complications. The typical clinical presentation is microangiopathic hemolytic anemia accompanied by thrombocytopenia with varying degrees of organ ischemia. The differential diagnoses are generally broad, while the workup is frequently complex and can be confusing. This statement represents the joint recommendations from a multidisciplinary team of Mayo Clinic physicians specializing in the management of TMA. It comprises a series of evidence- and consensus-based clinical pathways developed to allow a uniform approach to the spectrum of care including when to suspect TMA, what differential diagnoses to consider, which diagnostic tests to order, and how to provide initial empiric therapy, as well as some guidance on subsequent management. Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  12. Comparison of MMPI Scores of Drug Abusers and Mayo Clinic Normative Groups.

    Science.gov (United States)

    Patalano, Frank

    1980-01-01

    Compared MMPIs of 80 male and 80 female drug abusers with MMPIs of 550 male and 695 female medical patients. Male drug abusers obtained significantly higher scores than male medical patients on all clinical scales. Female drug abusers obtained significantly higher scores than female medical patients on seven scales. (Author)

  13. Patterns in deer-related traffic injuries over a decade: the Mayo clinic experience

    Directory of Open Access Journals (Sweden)

    Smoot Dustin L

    2010-08-01

    Full Text Available Abstract Background Our American College of Surgeons Level 1 Trauma Center serves a rural population. As a result, there is a unique set of accidents that are not present in an urban environment such as deer related motor vehicle crashes (dMVC. We characterized injury patterns between motorcycle/all-terrain vehicles (MCC and automobile (MVC crashes related to dMVC (deer motor vehicle crash with the hypotheses that MCC will present with higher Injury Severity Score (ISS and that it would be related to whether the driver struck the deer or swerved. Methods The records of 157 consecutive patients evaluated at our institution for injury related to dMVC from January 1st, 1997 to December 31st, 2006 were reviewed from our prospectively collected trauma database. Demographic, clinical, and crash specific parameters were abstracted. Injury severity was analyzed by the Abbreviated Injury Scale score for each body region as well as the overall Injury Severity Score (ISS. Results Motorcycle crashes presented with a higher median ISS than MVCs (14 vs 5, p Within the MVC group, there was no difference between swerving and hitting the deer in any AIS group. Forty-seven percent of drivers were not wearing seat belts which resulted in similar median ISS (6 vs 5 and AIS of all body regions. Conclusions Motorcycle operators suffered higher ISS. There were no significant differences in median ISS if a driver involved in a deer-related motor vehicle crash swerved rather than collided, was helmeted, or restrained.

  14. Subacute Cutaneous Lupus Erythematosus: Clinical Characteristics, Disease Associations, Treatments, and Outcomes in a Series of 90 Patients at Mayo Clinic, 1996-2011.

    Science.gov (United States)

    Alniemi, Dema T; Gutierrez, Albert; Drage, Lisa A; Wetter, David A

    2017-03-01

    To characterize the clinical presentation, laboratory studies, disease associations, and treatments of subacute cutaneous lupus erythematosus (SCLE). A retrospective review of 90 patients with SCLE at Mayo Clinic from January 1, 1996, through October 28, 2011, was performed. The mean patient age at diagnosis was 61 years; 64 patients (71%) were women, and 11 cases (12%) were drug induced (1996-2000, no drug-induced cases; 2001-2005, 2 cases; 2006-2011, 9 cases). Seventeen of 59 patients (29%) with available data were smokers at the time of diagnosis. The SCLE lesions were photodistributed in 75 patients (83%), and 52 (58%) had papulosquamous morphologic findings. Anti-Ro/SS-A positivity was present in 84 of 85 patients tested (99%), whereas 32 of the 85 patients (38%) tested positive for anti-La/SS-B. Associated autoimmune connective tissue diseases included Sjögren syndrome (n=13, 14%) and systemic lupus erythematosus (SLE) (n=8, 9%). Eighteen patients (20%) had at least 4 American College of Rheumatology criteria for SLE; 1 had lupus nephritis, and none had neurologic or notable hematologic sequelae. The most common therapy was hydroxychloroquine, with a complete response noted in 34 of 46 patients (74%) with available follow-up data. Twenty-eight percent of patients with SCLE (n=25) had an associated autoimmune connective tissue disease, although the severe sequelae of SLE, such as nephritis, were rare. The frequency of drug-induced SCLE increased during the study. Most patients responded to treatment with hydroxychloroquine. Copyright © 2016 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  15. The beginnings of Orthopedic Surgery at the Mayo Clinic: A Review of the First Orthopedic Patients who Presented Over 100 Years Ago.

    Science.gov (United States)

    Camp, Christopher L; Morrey, Bernard F; Trousdale, Robert T

    2016-01-01

    Formalized training in the specialty of orthopedic surgery began at the Mayo Clinic nearly 100 years ago, and treatment of patients with musculoskeletal injuries and disease began even earlier. A robust historical patient database provides the opportunity for review of the first recorded orthopedic cases at our institution, which date back to 1907. The first 400 sequential medical charts of the Mayo Clinic's patient record database were comprehensively reviewed in order to identify the first documented orthopedic cases. Of the first 400 patients reviewed, 15 (4%) received specific orthopedic diagnoses. All presented during a three week period in 1907, and they traveled from all over the region for evaluation. The diagnoses included skeletal tuberculosis (n=6), traumatic fracture (n=3), osteomyelitis (n=2), syphilitic pathologic fracture (n=1), syphilitic ostitis of the tibia and radius (n=1), painful flat foot (n=1), and Morton's toe (n=1). Included with the records are patient demographics, diagnoses, symptoms, physical examination findings, radiograph reports, operative reports, and detailed drawings of symptomatology. Although the technology and science has advanced since the early practice of orthopedic surgery that took place over a century ago, we consider ourselves to be merely an extension of those who established the field before us. Just as the past relies on the future for the continuation of what it began so many years ago, we rely on our founders for the groundwork that they laid in creating this field of surgical medicine.

  16. 2013 Suwannee River Water Management District Lidar: Mayo (FL)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Light Detection and Ranging (LiDAR) dataset is a survey of Suwannee River G12PD00242 1.0 Meter LiDAR Survey Area 4, Classified Point Cloud, in north-central...

  17. Phase I/II study of first-line irinotecan combined with 5-fluorouracil and folinic acid Mayo Clinic schedule in patients with advanced colorectal cancer

    Directory of Open Access Journals (Sweden)

    Davidson Neville

    2004-07-01

    Full Text Available Abstract Background This multicentre phase I/II study was designed to determine the maximum tolerated dose of irinotecan when combined with 5-fluorouracil and folinic acid according to the Mayo Clinic schedule and to evaluate the activity of this combination as first-line therapy in patients with advanced colorectal cancer. Methods Sixty-three patients received irinotecan (250 or 300 mg/m2, 30- to 90-minute intravenous infusion on day 1, immediately followed by folinic acid (20 mg/m2/day and 5-fluorouracil (425 mg/m2, 15-minute bolus infusion days 1 to 5, every four weeks. Results Diarrhoea was dose limiting at 300 mg/m2 irinotecan in combination with 5-fluorouracil and folinic acid, and this was determined to be the maximum tolerated dose. Grade 3–4 neutropenia was the most frequently reported toxicity. The recommended dose of irinotecan for the phase II part of the study was 250 mg/m2. The response rate for the evaluable patient population was 36% (13/36, and 44% (16 patients had stable disease (including 19% of minor response. For the intention-to-treat population, the response rate was 29% (14/49 and 35% (17 patients stable disease (including 14% of minor response. The median time to progression was 7.0 months and the median survival was 12.0 months. Grade 3–4 non-haematological drug-related toxicities included delayed diarrhoea, stomatitis, fatigue, and nausea/vomiting. There were three deaths due to septic shock that were possibly or probably treatment-related. Conclusions This regimen of irinotecan in combination with the Mayo Clinic schedule of bolus 5-fluorouracil/folinic acid every four weeks showed activity as first-line therapy in patients with advanced colorectal cancer. In keeping with other published results of studies using bolus 5-fluorouracil combined with irinotecan, the use of this regimen is limited by a relatively high rate of grade 3–4 neutropenia, and the combination of irinotecan and infusional 5-fluorouracil

  18. Effects of different hormone therapies on breast pain in recently postmenopausal women: findings from the Mayo Clinic KEEPS breast pain ancillary study.

    Science.gov (United States)

    Files, Julia A; Miller, Virginia M; Cha, Stephen S; Pruthi, Sandhya

    2014-10-01

    Abstract Background: It is estimated that 70% of women in Western societies experience breast pain at least once during their lifetime. In the Women's Health Initiative (WHI), women treated with oral conjugated equine estrogen (0.625 mg) with or without continuous oral medroxyprogesterone acetate (2.5 mg) had a higher incidence of breast pain than those who received placebo. The effect of other hormone therapy regimens on breast pain is unknown. We compared breast pain among healthy, recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS) at Mayo Clinic. Women were randomized to: 0.45 mg/day oral conjugated equine estrogen (o-CEE) plus 200 mg/day micronized progesterone (m-P) for the first 12 days of the month, 50 μg/day transdermal 17β estradiol (t-E2) plus m-P for 12 days, or placebo pills and patch. Participants completed the Mayo Clinic breast pain questionnaire at baseline and yearly for the duration of the study. Participants (116) averaged 53.0 years of age and 1.6 years past their last menses at baseline. At baseline, 12 women (10%) reported breast pain with an average worst pain score [from 0 (no pain) to 10 (worst pain)] of 0.39±1.28. With treatment, the number of women reporting pain did not increase, and with either intention-to-treat or per-protocol analyses, breast pain scores did not differ significantly (p=0.39) among groups: t-E2 (0.53±1.21), o-CEE (0.32±0.78), placebo (0.23±0.87). Four years of treatment with o-CEE at a lower dose than that studied in the WHI with cyclic m-P or transdermal E2 with cyclic m-P did not increase breast pain in healthy, recently menopausal women.

  19. In newly diagnosed breast cancer, screening MRI of the contralateral breast detects mammographically occult cancer, even in elderly women: the mayo clinic in Florida experience.

    Science.gov (United States)

    Bernard, Johnny Ray; Vallow, Laura A; DePeri, Elizabeth R; McNeil, Rebecca B; Feigel, Deborah G; Amar, Surabhi; Buskirk, Steven J; Perez, Edith A

    2010-01-01

    The role of magnetic resonance imaging (MRI) in patients with newly diagnosed breast cancer is somewhat controversial. The purpose of this study was to evaluate the prevalence of synchronous, occult contralateral breast cancer detected by MRI but not by mammography or clinical breast examination in women with newly diagnosed breast cancer, including those aged 70 years or older at our institution. MRI results for women with newly diagnosed breast cancer who underwent bilateral breast MRI after negative mammography and clinical examination between February 2003 and November 2007 at Mayo Clinic in Florida were reviewed. The prevalence of pathologically confirmed contralateral carcinoma diagnosed solely by MRI was determined and analyzed in the context of age, family history, menopausal status, breast density, and primary-tumor characteristics. Logistic regression was used to explore the association between contralateral carcinoma and potential patient risk factors. A total of 425 women were evaluated, of whom 129 (30%) were aged 70 years or older. A contralateral biopsy was recommended and performed solely on the basis of MRI in 72 of the 425 women (17%). Sixteen of these 72 women (22%) had pathologically confirmed carcinoma, including seven in the older subgroup. The prevalence of clinically and mammographically occult contralateral carcinoma detected by MRI was 3.8% (16/425) overall and 5.4% (7/129) in the group of older women. When potential risk factors for contralateral breast cancer were evaluated, postmenopausal status was the only significant predictor of contralateral cancer detected by MRI (p = 0.016). We concluded that contralateral breast screening with MRI should be considered in postmenopausal women with newly diagnosed breast cancer, even those aged 70 years or older at diagnosis.

  20. Mayo Registry for Telemetry Efficacy in Arrest Study: An Assessment of the Utility of Telemetry in Predicting Clinical Decompensation.

    Science.gov (United States)

    Snipelisky, David; Ray, Jordan; Matcha, Gautam; Roy, Archana; Harris, Dana; Bosworth, Veronica; Dumitrascu, Adrian; Clark, Brooke; Vadeboncoeur, Tyler; Kusumoto, Fred; Bowman, Cammi; Burton, M Caroline

    2016-02-17

    Our study assesses the utility of telemetry in identifying decompensation in patients with documented cardiopulmonary arrest. A retrospective review of inpatients who experienced a cardiopulmonary arrest from May 1, 2008, until June 30, 2014, was performed. Telemetry records 24 hours prior to and immediately preceding cardiopulmonary arrest were reviewed. Patient subanalyses based on clinical demographics were made as well as analyses of survival comparing patients with identifiable rhythm changes in telemetry to those without. Of 242 patients included in the study, 75 (31.0%) and 110 (45.5%) experienced telemetry changes at the 24-hour and immediately preceding time periods, respectively. Of the telemetry changes, the majority were classified as nonmalignant (n = 50, 66.7% and n = 66, 55.5% at 24 hours prior and immediately preceding, respectively). There was no difference in telemetry changes between intensive care unit (ICU) and non-ICU patients and among patients stratified according to the American Heart Association telemetry indications. There was no difference in survival when comparing patients with telemetry changes immediately preceding and at 24 hours prior to an event (n = 30, 27.3% and n = 15, 20.0%) to those without telemetry changes during the same periods (n = 27, 20.5% and n = 42, 25.2%; P = .22 and .39). Telemetry has limited utility in predicting clinical decompensation in the inpatient setting. © The Author(s) 2016.

  1. Editorial REDVET Mayo/2009

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    veterinaria.org

    2009-05-01

    Full Text Available ResumenUn mes más y de manera puntual presentamos el número deREDVET correspondiente a Mayo.El brote de influenza H1N1 ha inundado los medios, tantos losespecializados como la prensa general y sensacionalista conabundante información. En REDVET a ello le dedicamos la otraeditorial (“Sobre la Gripe porcina A (H1N1 notificados en personas”y un par de artículos cortos de tipo divulgativo (“La Gripe Mexicana”y “Algunos aspectos ligados a la Influenza porcina”, que se unen a“Siglo XXI: ¿Era de las Zoonosis?” y “Foca arpa, un mundoinsostenible, sordo y ciego”, en el mismo apartado de divulgación.

  2. African American Women's Perceptions and Attitudes Regarding Participation in Medical Research: The Mayo Clinic/The Links, Incorporated Partnership

    Science.gov (United States)

    Brewer, LaPrincess C.; Parker, Monica W.; Balls-Berry, Joyce E.; Halyard, Michele Y.; Pinn, Vivian W.; Radecki Breitkopf, Carmen

    2014-01-01

    Abstract Objective: To examine perceptions and attitudes toward health-related research participation among professional African American women. Methods: Participants were members of an African American women's service organization, The Links, Incorporated. Data were collected via self-administered questionnaires at The Links, Incorporated 2012 National Assembly. Sociodemographics, prior research experience, intention to participate (ITP), willingness to participate (WTP) in a variety of research studies and attitudes about research participation were measured. Results: A total of 381 surveys were analyzed. A majority of respondents were married (66%), employed (69%), and college educated (96%). Median age was 59; 38% reported prior research participation. Overall, 78% agreed with the statement, “Participation in research will mean better care,” 24% agreed “Participation in research is risky” and 3% agreed “Scientists cannot be trusted.” Fifty-two percent agreed with the statement, “Research conducted in the U.S. is ethical.” Mean ITP in research was 4.9±1.7 on a rating scale of 1 (“definitely no”) to 7 (“definitely yes”). WTP was highest for an interview study and providing a blood sample, and lowest for clinical trial and medical record review. Conclusion: Attitudes toward research participation were generally favorable among professional African American women; many expressed WTP in a variety of research study types. PMID:25046058

  3. William and Charles Mayo: their influence on American medicine.

    Science.gov (United States)

    Anaya-Prado, Roberto; Rubí, Marisol Godínez

    2007-01-01

    In a little-known Midwest town named Rochester, Minnesota, a talented physician grew in fame and respect: Dr. William Worrall Mayo, who was influential in the evolution of medicine. He was a steadfast learner and raised two sons, William and Charles, to follow in his footsteps and further medical knowledge. They were leaders in surgery and in the creation of advanced and sophisticated medical facilities. Their talents, the issues surrounding medical practice, and unexpected opportunity all came into play for the Mayos. Two hospitals, St. Mary's Hospital and later the Methodist Hospital, witnessed and influenced the advancement of medicine through the Mayo Clinic heritage and dynasty in Minnesota and the rest of the world. In this article, we focus on the role of the Mayo brothers and their influence over the increasing acceptance of hospital care in America and abroad.

  4. Mayo de Los Capomos, Sinaloa (Mayo of Los Capomos, Sinaloa).

    Science.gov (United States)

    Freeze, Ray A.

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Mayo, an indigenous language of Mexico spoken in Los Capomos, in the state of Sinaloa. The objective of collecting such a representative sampling of the…

  5. Carlos Mayo and Argentine historiography

    Directory of Open Access Journals (Sweden)

    Sara E. Mata

    2012-11-01

    Full Text Available The work of Carlos Mayo is distinguished by its originality and academic excellence. Our goal has been to briefly address their valuable contributions to the Argentine historiography, particularly that relating to the agricultural history of the Río de la Plata

  6. The Mayo Innovation Scholars Program: Undergraduates Explore the Science and Economics of Medical Innovations

    Science.gov (United States)

    Pellegrini, John J.; Jansen, Elizabeth

    2013-01-01

    The Mayo Innovation Scholars Program introduces undergraduates to technology transfer in biomedical sciences by having teams of students from multiple disciplines (e.g., biology, chemistry, economics, and business) analyze inventions in development at the Mayo Clinic. Over 6 months, teams consult with inventors, intellectual property experts, and…

  7. Mayo v. Prometheus: A Year Later.

    Science.gov (United States)

    Dorn, Brian R

    2013-07-11

    Last year's U.S. Supreme Court decision in Mayo v. Prometheus regarding the patent eligibility of diagnostic method claims will probably have the most profound lasting effect of any recent court decision on the biopharmaceutical industry. The Mayo decision changed the evaluation of patent eligibility of a method claim under 35 U.S.C. § 101. The new evaluation is a more difficult standard to clear and needs to be considered prior to filing a patent application.

  8. Test Reviews: Bracken, B. A., & Howell, K. (2004). "Clinical Assessment of Depression." Odessa, FL: Psychological Assessment Resources

    Science.gov (United States)

    Aghakhani, Anoosha; Chan, Eric K.

    2007-01-01

    In this article, the authors review the Clinical Assessment of Depression (CAD), a 50-item self-report measure of depressive symptoms designed for children, adolescents, adults, and elderly adults from 8 to 79 years of age. Purporting to be sensitive to depressive symptomatology across the lifespan, the test items were written to reflect the…

  9. Transforming Research Management Systems at Mayo Clinic

    Science.gov (United States)

    Smith, Steven C.; Gronseth, Darren L.

    2011-01-01

    In order for research programs at academic medical centers and universities to survive and thrive in the increasingly challenging economic, political and regulatory environment, successful transformation is extremely important. Transformation and quality management techniques are increasingly well established in medical practice organizations. In…

  10. Elton Mayo and Carl Rogers: A Tale of Two Techniques.

    Science.gov (United States)

    Mahoney, Kevin T.; Baker, David B.

    2002-01-01

    Compares the simultaneous emergence of Mayo's nonauthoritarian interviewing approach and Rogers' nondirective counseling approach. Examines the influence of Piaget on Mayo and reviews the Hawthorne studies. Concludes that differences in the approaches outweigh similarities. (Contains 21 references.) (SK)

  11. Brookvale Manor, Hazelhill, Ballyhaunis, Mayo

    LENUS (Irish Health Repository)

    Hawkes, C P

    2010-01-01

    Egg allergy is incorrectly considered to constitute a contraindication to MMR in the community, despite a long history of its safe administration to egg allergic children. The product insert perpetuates this misinformation but the Irish guidelines from the RCPI are unequivocal. We reviewed all paediatric cases vaccinated in our hospital in 2007-2008. Forty seven of 91 children receiving vaccinations in hospital, had been referred for MMR due to concerns regarding egg allergy. In 32% (n=15), GP referral for vaccination was made despite correspondence from the clinic advising routine vaccination in the community. Nineteen were second MMR immunisations, which should all have occurred in the community. Unnecessary hospital referral for MMR vaccination is an extra burden on hospital resources, and causes unwarranted anxiety amongst parents of children with egg allergy. A change in practice seems difficult to achieve, as many referrals happen despite individualised correspondence to GPs and other referring clinicians outlining the current guidelines.

  12. FL Writing Plays a Significant Role in FL Learning

    Institute of Scientific and Technical Information of China (English)

    HouTianzhen

    2004-01-01

    The view of writing as a tool for learning and not just a means to demonstrate learning is one of the major contributions of the research into the writing process (Emig1977). No matter what teaching approaches are applied, the four basic languages kills are interactive and cooperative. In our traditional FL teaching, however, FL writing was always regarded as the most

  13. Time-trend analysis on the Framingham risk score and prevalence of cardiovascular risk factors in patients undergoing percutaneous coronary intervention without prior history of coronary vascular disease over the last 17 years: a study from the Mayo Clinic PCI registry.

    Science.gov (United States)

    Lee, Moo-Sik; Flammer, Andreas J; Li, Jing; Lennon, Ryan J; Singh, Mandeep; Holmes, David R; Rihal, Charanjit S; Lerman, Amir

    2014-07-01

    There is a paucity of data on the temporal trends of cardiovascular risk factors in patients undergoing percutaneous coronary intervention (PCI). We investigated the secular trends of risk profiles of patients undergoing PCI without prior history of cardiovascular disease (CVD). CVD risk factors are changed over time. This time-trend analysis from 1994 to 2010 was performed within the Mayo Clinic PCI Registry. Outcome measures were prevalence of CVD risk factors, including the Framingham risk score (FRS), at the time of admission for PCI. During this period, 12,055 patients without a history of CVD (mean age, 65.0 ± 12.4 years, 67% male) underwent PCI at the Mayo Clinic. Age distribution slightly shifted toward older age (P for trend trend trend trend trend <0.001), whereas smoking prevalence did not change. The current study demonstrates that although traditional FRS and its associated predicted 10-year cardiovascular risk declined over time, the prevalence of risk factors increased in patients undergoing PCI. The study suggests the need for a new risk-factor assessment in this patient population. © 2014 Wiley Periodicals, Inc.

  14. Follicular lymphoma (FL): Immunological tolerance theory in FL.

    Science.gov (United States)

    García-Muñoz, Ricardo; Panizo, Carlos

    2017-02-01

    The ultimate cause of follicular lymphoma (FL) remains unknown. Remarkably, almost nothing is known about immunological tolerance mechanisms that might contribute to FL development. Immunological tolerance mechanisms, like other stimuli, also induce persistent changes of B cell receptors that induce genetic instability and molecular aberrations promoting the development of a neoplasm. Using the same method as Burnet, we provide a new perspective taking advantage of the comparison of a normal linear B cell differentiation process and FL development within the framework of clonal selection theory. We propose that FL is a malignancy of cells that acquire both translocation t(14;18) and self-BCR, inducing them to proliferate and mature, resistant to negative selection. Additional genetic damage induced by non-apoptotic tolerance mechanisms, such as receptor editing, may transform a self-reactive B cell with t(14;18) into an FL. The result of tolerogenic mechanisms and genetic aberrations is the survival of FL B cell clones with similar markers and homogenous gene expression signatures despite the different stages of maturation at which the molecular damage occurs. To antagonize further growth advantage due to self-antigen recognition and chronic activation of tolerance mechanisms in the apoptosis-resistant background of FL B cells, inhibitors of BCR signaling may be promising therapeutic options.

  15. Le nonne di Plaza de Mayo

    Directory of Open Access Journals (Sweden)

    Benedetta Calandra

    2006-11-01

    Full Text Available The article is focused on a specific case study of ‘motherist movement’ in Argentina during the last military rule (1976-1983: the Grandmothers of Plaza de Mayo. Blurring the boundaries between public and private realm, these old women, without a previous, soundly-based political conscience, were able to set up a transnational human rights movement, well known all over the world, while looking for their abducted grandchildren. A crucial issue, still, is: how far did this group go in terms of advocating womens’ rights? Could we really find a correspondence, as Jelin puts it, between ‘women for human rights’ and ‘women for women’s rights’? The answer, as the Argentinean case shows, seems to be not so straightforward.

  16. Against the Corporate Culture Ideology: An Interview with Peter Mayo

    Science.gov (United States)

    Suoranta, Juha

    2010-01-01

    This article presents an interview with Peter Mayo, author and expert in the field of sociology of adult education, on his major influences in this area, his books, and his views on the role of radical adult education and radical scholarship in the future. In the interview, Peter Mayo states that his initial view of adult education was quite a…

  17. Against the Corporate Culture Ideology: An Interview with Peter Mayo

    Science.gov (United States)

    Suoranta, Juha

    2010-01-01

    This article presents an interview with Peter Mayo, author and expert in the field of sociology of adult education, on his major influences in this area, his books, and his views on the role of radical adult education and radical scholarship in the future. In the interview, Peter Mayo states that his initial view of adult education was quite a…

  18. El paro estudiantil de mayo de 1938

    Directory of Open Access Journals (Sweden)

    Orlando Moreno Martínez

    2010-10-01

    Full Text Available El presente artículo tiene como propósito analizar los sucesos ocurridos en la ciudad de Bogotá durante el paro estudiantil de mayo de 1938, programado para oponerse a algunas medidas de modernización y secularización educativa impuestas por el gobierno liberal del presidente Alfonso López Pumarejo. Específicamente, los estudiantes se levantaron contra el examen de revisión que se aplicaba al terminar la secundaria y el curso preparatorio que era un requisito para poder ingresar a la universidad. El escrito aborda la problemática suscitada por la reforma educativa, el desencadenamiento de la protesta estudiantil, las acciones desarrolladas por los estudiantes en la capital de la República, el impacto del movimiento en otras partes del país y las tendencias ideológicas que apoyaron el paro de estudiantes. A propósito de este último punto, si bien fue evidente el respaldo de la oposición conservadora, muchos estudiantes universitarios y de secundaria lucharon con convicción por lo que consideraron en su momento una arbitrariedad por parte del gobierno liberal.

  19. Estadísticas culturales de Colombia: mayo de 1969

    Directory of Open Access Journals (Sweden)

    Fernán Torres León

    1969-05-01

    Full Text Available El documento presenta un cuadro comparativo de las actividades culturales del pais, así como las exposiciones de artes plasticas y otras inauguradas en el pais en el mes de mayo de 1969

  20. Fløng-modellerne

    DEFF Research Database (Denmark)

    Karnøe, Jonatan Kolding

    2014-01-01

    Artiklen giver indblik i, hvilke kompetencer lærerne på Fløng Skole oplever som forudsætning for, at eleverne har gavn af deres iPad i en læringssammenhæng. Herudfra er der udviklet to redskaber – F-KO-modellen og F-KOP-modellen.......Artiklen giver indblik i, hvilke kompetencer lærerne på Fløng Skole oplever som forudsætning for, at eleverne har gavn af deres iPad i en læringssammenhæng. Herudfra er der udviklet to redskaber – F-KO-modellen og F-KOP-modellen....

  1. Las actividades de la Comisión Europea en materia de Derecho internacional privado en el periodo mayo 2015– mayo 2016

    OpenAIRE

    Lafuente Sánchez, Raúl

    2016-01-01

    El presente trabajo tiene por objeto informar sobre las actividades desarrolladas por la Comisión Europea en materias relacionadas con el Derecho internacional privado durante el periodo comprendido entre mayo 2015 y mayo 2016.

  2. 33 CFR 80.727 - Cape Canaveral, FL to Miami Beach, FL.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Cape Canaveral, FL to Miami Beach, FL. 80.727 Section 80.727 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND..., FL to Miami Beach, FL. (a) A line drawn across the seaward extremity of the Port Canaveral...

  3. 46 CFR 7.95 - St. Johns Point, FL to Miami Beach, FL.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false St. Johns Point, FL to Miami Beach, FL. 7.95 Section 7.95 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Atlantic Coast § 7.95 St. Johns Point, FL to Miami Beach, FL. (a) A line drawn from the...

  4. Specialized consultant in radiological safety to the Reforma peripheral clinic, PEMEX. - I. - May-June of 2003; Asesoria especializada en seguridad radiologica a la clinica periferica Reforma, PEMEX.- I.- Mayo-Junio de 2003

    Energy Technology Data Exchange (ETDEWEB)

    Torres P, A.; Garcia A, J.; Rodriguez A, F

    2003-07-15

    The Reforma peripheral clinic, dependent of PEMEX, It request consultant of the ININ to be able to maintain their sanitary license for the use of X-ray equipment for the radiologic diagnostic.The proposal of the ININ was to be a program of technical attendance, schedule monthly to be able to solve the observations that are presented in the use of those equipment, and that the clinic can conserve its respective sanitary license.(Author)

  5. Clinical utilities of aromatase inhibitors in breast cancer

    Directory of Open Access Journals (Sweden)

    Chumsri S

    2015-05-01

    Full Text Available Saranya Chumsri Department of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA Abstract: Aromatase is an enzyme that converts testosterones to estrogens. Inhibition of this enzyme has been shown to have several clinical utilities in breast cancer. Currently, there are three aromatase inhibitors (AIs in clinical use, namely anastrozole, letrozole, and exemestane. AIs have been used in various clinical settings for breast cancer, ranging from chemoprevention in breast cancer to treating breast cancer in both early stage in the adjuvant setting and metastatic disease. This article reviews mechanism of action, AI classification, and clinical utilities of AIs in various clinical settings in the context of breast cancer. Keywords: aromatase inhibitor, endocrine therapy, breast cancer

  6. Estadísticas culturales de Colombia: mayo de 1966

    Directory of Open Access Journals (Sweden)

    Fernán Torres León

    1966-05-01

    Full Text Available El documento presenta un cuadro comparativo de las actividades culturales del pais, así como las exposiciones de artes plasticas y otras inauguradas, recitales poéticos, conciertos y recitales de música, libros de autores colombianos publicados y representaciones teatrales realizadas en el pais en el mes de mayo de 1966.

  7. Estadísticas culturales de Colombia: mayo de 1967

    Directory of Open Access Journals (Sweden)

    Fernán Torres León

    1967-05-01

    Full Text Available El documento presenta un cuadro comparativo de las actividades culturales del pais, así como las exposiciones de artes plasticas y otras inauguradas, recitales poéticos, conciertos y recitales de música, libros de autores colombianos publicados y representaciones teatrales realizadas en el pais en el mes de mayo de 1967

  8. Estadísticas culturales de Colombia: Mayo de 1968

    Directory of Open Access Journals (Sweden)

    Fernán Torres León

    1968-05-01

    Full Text Available El documento presenta un cuadro comparativo de las actividades culturales del país. Además, se presenta información sobre las exposiciones de artes plasticas y otras inauguradas en el país durante el mes de mayo de 1968.

  9. "Quadruple whammy"- a preventable newly described syndrome of post-operative AKI in CKD II and CKD III patients on combination "Triple whammy" medications: a Mayo Clinic Health System, Eau Claire, Wisconsin experience.

    Science.gov (United States)

    Onuigbo, M A; Agbasi, N

    2014-01-01

    The potential combination of diuretics- angiotensin-converting enzyme inhibitors- Non-steroidal anti-inflammatory drugs (diuretics-ACEIs-NSAIDs), the so-called 'triple whammy', to produce clinically significant nephrotoxicity in chronic kidney disease (CKD) is often unrecognized. In 2013, in the British Medical Journal, we described accelerated post-operative acute kidney injury (AKI) in CKD patients concurrently on 'triple whammy' medications, a new syndrome that we aptly named 'quadruple whammy'. Two case reports. I. A 59-year-old Caucasian male, hypertensive CKD III, serum creatinine (SCr) 1.42 mg/dL, developed accelerated oliguric AKI after elective right nephrectomy. Outpatient medications included Lisinopril-Hydrochlorothiazide and Nabumetone (NSAID). SCr rapidly more than doubled with metabolic acidosis and hyperkalemia within 24 hours, peaking at 4.02 mg/dL. 'Triple whammy' medications were promptly stopped and the hypotension was corrected. SCr was 1.64 mg/dL and stable, after three months. II. A 46-year-old Caucasian male, hypertensive CKD II, SCr 1.21 mg/dL, developed accelerated AKI after elective right hip arthroplasty. Outpatient medications included Lisinopril and Hydrochlorothiazide. Celecoxib (200 mg) was given pre-operatively. Within 36 hours, SCr rapidly more than doubled to 2.58 mg/dL, with metabolic acidosis. 'Triple whammy' medications were promptly stopped and the hypotension was corrected. SCr was 0.99 mg/dL, and stable, after one month. We have described two cases of preventable accelerated AKI following post-operative hypotension in CKD patients concurrently on 'triple whammy' medications. We dubbed this new syndrome "Quadruple Whammy". It is not uncommon. 'Renoprevention', the pre-emptive withholding of (potentially nephrotoxic) medications, including 'triple whammy' medications, pre-operatively, in CKD patients, together with the simultaneous avoidance of peri-operative hypotension would help reduce, if not eliminate such AKI - a call

  10. 光固化流体树脂美容修复乳前牙龋的疗效观察%Clinical effect of light curing fl uid resin in the treatment of dental caries in primary teeth

    Institute of Scientific and Technical Information of China (English)

    高艳蕾; 李凌; 袁昌青

    2015-01-01

    ObjectiveTo explore the clinical effect of light curing fluid resin used in cosmetic restoration of dental caries.MethodsFrom February 2014 to April 2015, 92 patients with dental caries were selected. The patients were divided into observation group and control group with 40 cases, 52 cases were treated by light curing fl uid resin and the control group was treated with light cured composite resin. The effect and complications of two groups were compared.ResultsThe total recovery rate of the observation group was higher than that of the control group, and the incidence of complications was lower than that of the control group(P<0.05).ConclusionThe clinical effect of light curing fluid resin used in cosmetic restoration of anterior teeth is signifi cant. Worthy of clinical popularization and Application.%目的:观察光固化流体树脂用于美容修复乳前牙龋的疗效。方法选取2014年2月~2015年4月某院收治的乳前牙龋患儿92例,将其按照治疗所用方法分为观察组52例与对照组40例,观察组行光固化流体树脂修复,对照组行光固化复合树脂修复,比较两组修复效果及并发症情况。结果观察组总修复率比对照组高,且并发症发生率比对照组低,差异有统计学意义(P<0.05)。结论光固化流体树脂用于美容修复乳前牙的疗效显著。值得临床推广应用。

  11. Pilgrim's Rest, Barley Hill, Westport, Mayo.

    LENUS (Irish Health Repository)

    Stack, Austin G

    2014-01-01

    Chronic Kidney Disease (CKD) is a major non-communicable chronic disease that is associated with adverse clinical and economic outcomes. Passive surveillance systems are likely to improve efforts for prevention of chronic kidney disease (CKD) and inform national service planning. This study was conducted to determine the overall prevalence of CKD in the Irish health system, assess period trends and explore patterns of variation as part of a novel surveillance initiative.

  12. An Academic Healthcare Twitter Account: The Mayo Clinic Experience.

    Science.gov (United States)

    Widmer, R Jay; Engler, Nicole B; Geske, Jeffrey B; Klarich, Kyle W; Timimi, Farris K

    2016-06-01

    With more than 300 million monthly active users, Twitter is a powerful social media tool in healthcare, yet the characterization of an academic healthcare Twitter account remains poor to date. We assessed basic gender and geographic data on the account's "followers," as well as categorization of each tweet based on content type. We analyzed the impressions, engagements, retweets, favorites, replies, hashtag clicks, and detail expansions using both Sprinklr and Twitter Analytics. Over a period of 12 months, the account amassed 1,235 followers, with 54 percent being male and 68 percent residing in the United States. Of the 1,635 tweets sent out over the life of the account, we report more than 382,464 impressions, 6,023 engagements, 1,255 retweets, 776 favorites, and 1,654 embedded media clicks in this period. When broken down by tweet category, publication tweets garnered the highest engagement with an estimated mean number of clicks per tweet of 8.2 ± 81.9. Original content had higher total engagement per tweet than retweeted material (2.8 ± 9.2 vs. 0.2 ± 0.9 engagements per tweet; p importance of combining physician-led knowledge with intermittent marketing messages.

  13. Australian influences on Elton Mayo: the construct of Revery in industrial society.

    Science.gov (United States)

    Griffin, Mark A; Landy, Frank J; Mayocchi, Lisa

    2002-11-01

    Elton Mayo was born in Australia and spent most of his first 42 years living in that country. This article explores the Australian context in which he developed his views views of Australia compared with that of the United States during the time that Mayo developed his approach to psychology and the role of workers in industry. In addition, the social context in which Mayo established his career was shaped by significant political events in Australia. The construct of revery, which describes a specific state of consciousness, is central to Mayo's early theorizing and was developed by Mayo partly in reaction to political and industrial conflict occurring in Australia.

  14. Remembering Joseph Mayo and His Contributions to Animal Science | Poster

    Science.gov (United States)

    By Carolynne Keenan, Guest Writer In the 1990s, when Joseph Mayo, D.V.M, ran out of gas leading coworkers home from a meeting in Bethesda, he pulled over to the side of the road on I-270 and waited for help. He didn’t have to wait long; within a few minutes a passing motorist took pity on the group of scientists and offered them a lift back to Fort Detrick.

  15. Estadísticas culturales de Colombia: mayo de 1964

    Directory of Open Access Journals (Sweden)

    Fernán Torres León

    1964-05-01

    Full Text Available El documento presenta un cuadro comparativo de las actividades culturales del país, así como las exposiciones de artes plásticas y otras inauguradas, recitales poéticos, conciertos y recitales de música, libros de autores colombianos publicados y representaciones teatrales realizadas en el país en el mes de mayo de 1964

  16. Estadísticas culturales de Colombia: mayo de 1965

    Directory of Open Access Journals (Sweden)

    Fernán Torres León

    1965-05-01

    Full Text Available El documento presenta un cuadro comparativo de las actividades culturales del país, así como las exposiciones de artes plásticas y otras inauguradas, recitales poéticos, conciertos y recitales de música, libros de autores colombianos publicados y representaciones teatrales realizadas en el país en el mes de mayo de 1965.

  17. 2008 St. Johns County, FL Countywide Lidar

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Airborne terrestrial LiDAR was collected for St. Johns County, FL. System Parameters/Flight Plan. The LiDAR system acquisition parameters were developed based on a...

  18. Mayo's Older African Americans Normative Studies: WMS-R norms for African American elders.

    Science.gov (United States)

    Lucas, John A; Ivnik, Robert J; Smith, Glenn E; Ferman, Tanis J; Willis, Floyd B; Petersen, Ronald C; Graff-Radford, Neill R

    2005-06-01

    Norms for African American elders on the Wechsler Memory Scale-Revised (WMS-R) were derived from a sample of 309 community-dwelling individuals participating in Mayo's Older African Americans Normative Studies (MOAANS). Normative estimates are provided for traditional WMS-R subtest scores and for supplemental procedures to evaluate forgetting rates and recognition memory. Tables are provided to convert raw WMS-R subtest and supplemental scores to age-corrected scaled scores. These may be further adjusted for years of education, if desired, by applying regression-based corrections. We anticipate that these data will enhance the diagnostic utility and clinical interpretation of WMS-R performance in older African Americans.

  19. 77 FR 66083 - Florida Disaster # FL-00076

    Science.gov (United States)

    2012-11-01

    ... ADMINISTRATION Florida Disaster FL-00076 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the... Kingsport Road, Fort Worth, TX 76155. FOR FURTHER INFORMATION CONTACT: A. Escobar, Office of...

  20. 77 FR 42352 - Florida Disaster #FL-00072

    Science.gov (United States)

    2012-07-18

    ... ADMINISTRATION Florida Disaster FL-00072 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... loan applications to: U.S. Small Business Administration, Processing and Disbursement Center, 14925... Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington, DC...

  1. 78 FR 48763 - Florida Disaster #FL-00090

    Science.gov (United States)

    2013-08-09

    ... ADMINISTRATION Florida Disaster FL-00090 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY... completed loan applications to: U.S. Small Business Administration, Processing and Disbursement Center... Disaster Assistance, U.S. Small Business Administration, 409 3rd Street SW., Suite 6050, Washington,...

  2. Draft Genome Sequence of Mycobacterium chimaera Type Strain Fl-0169

    Science.gov (United States)

    We report the draft genome sequence of the type strain Mycobacterium chimaera Fl-0169T, a member of the Mycobacterium avium complex (MAC). M. chimaera Fl-0169T was isolated from a patient in Italy and is highly similar to strains of M. chimaera isolated in Ireland, though Fl-016...

  3. 76 FR 35966 - Amendment of Class E Airspace; Cocoa, FL

    Science.gov (United States)

    2011-06-21

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Cocoa, FL AGENCY: Federal... Cocoa, FL, as the Merritt Island Non-Directional Beacon (NDB) has been decommissioned and new Standard... Merritt Island Airport, Cocoa, FL (75 FR 21266) Docket No. FAA-2011-0070. Interested parties were...

  4. Immunotherapeutic Strategies in Breast Cancer: Preclinical and Clinical Trials

    Science.gov (United States)

    2008-09-01

    Study Co-chairs: James N. Ingle , M.D (Mayo Clinic, Rochester) Pinku Mukherjee, Ph. D (Mayo Clinic, Scottsdale) √ Tom Fitch, M.D (Mayo Clinic...Not reported: Patient refused or not available ___ Unknown: Patient unsure Ethnicity (check one) ___ Not Hispanic or Latino ___ Hispanic or... Latino ___ Not reported: Refused or data not available ___ Unknown: Unsure of their ethnicity 55 MCCC Pre-Registration (Step 1) Eligibility Checklist

  5. Study on Mobile Augmented Reality Adoption for Mayo Language Learning

    Directory of Open Access Journals (Sweden)

    Erasmo Miranda Bojórquez

    2016-01-01

    Full Text Available This paper presents the results of a study applied to undergraduates in order to know how the cultural dimensions affect their perceptions of the acceptance and use of new technologies in a student-centered learning environment. A total of 85 undergraduate students from the Autonomous Indigenous University of Mexico (UAIM participated in the study. Each student was asked to use a mobile augmented reality (MAR application designed to learn Mayo language (language spoken in Northwestern Mexico. Afterwards, the students responded to a survey with items concerning the use and technology acceptance and about cultural dimensions of individualism and uncertainty avoidance. Structural equation modeling (SEM was used to analyze the data collected from students. Results provide evidence that the individualism contributes positively to perceived ease of use of the MAR app, and uncertainty avoidance has no impact. The findings showed that the MAR system could be easily used if it includes a natural way to promote collaborative work. In addition, to gain the trust of students, the uncertainty avoidance needs to be reduced by enriching the help information offered for app use.

  6. Drilling optimization methodology - 25 de Mayo El Medanito - Neuquen - Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Aguero, Guillermo [Smith International, Inc., Houston, TX (United States); Lugones, Juan M. [PETROBRAS Argentina S.A. (Argentina); Marzialetti, Humberto [Pride San Antonio (Argentina)

    2004-07-01

    This paper was prepared based on the optimization of the performance and wear pattern of Polycrystalline Diamond Cutter (PDC) bits used in 25 de Mayo S.E. El Medanito Field, Neuquen/Argentina out of a joint effort done by the operator and the service company. The main objective was to reach the casing point in a single bit run at a reasonable penetration rate of the 8 1/2'' section (Choiyoi Formation - Igneous Rock), in order to avoid the use of an extra tungsten carbide insert roller cone bit to reach (4400 ft) which increases the drilling costs as well as allows to a higher exposure to accidents during trips in and out of the hole. A methodology was introduced to the field operations enabling a close follow-up to optimize the drill bit cutting structures, operating conditions, as well as the incorporation of state-of-the-art technology regarding cutters and its geometry. This proved less wear on cutting structures of PDC bits, leading to the achievement of the established casing set depth with reduction of drilling hours and being cost effective to the Operator. (author)

  7. Psychometric properties of the Mayo Elbow Performance Score.

    Science.gov (United States)

    Celik, Derya

    2015-06-01

    To translate and culturally adapt the Mayo Elbow Performance Score (MEPS), a widely used instrument for evaluating disability associated with elbow injuries, into Turkish (MEPS-T) and to determine psychometric properties of the translated version. The MEPS was translated into Turkish using published methodological guidelines. The measurement properties of the MEPS-T (construct validity and floor and ceiling effects) were tested in 91 patients with elbow pathology. The reproducibility of the MEPS-T was tested in 59 patients over 7-14 days. The responsiveness of the MEPS-T was tested in a subgroup of 46 patients diagnosed with lateral epicondylitis and who received conservative treatment for 6 weeks. The interclass correlation coefficient (ICC) was used to estimate the test-retest reliability. The construct validity was analyzed with the disabilities of the arm, shoulder and hand (DASH), Visual Analog Scale (VAS) and the Short Form 36 (SF-36). Effect size (ES) was used to assess the responsiveness. The distribution of floor and ceiling effects was determined. The MEPS-T showed very good test-retest reliability (ICC 0.89). The correlation coefficients between the MEPS-T and DASH and VAS were -0.61 and -0.53, respectively (p elbow disease.

  8. Mida mõtleb professor Andrew Mayo? / Anne-Mari Ernesaks

    Index Scriptorium Estoniae

    Ernesaks, Anne-Mari

    2005-01-01

    PARE koordinaator tutvustab tuntud inimkapitali ideoloogi Andrew Mayo raamatut "Ettevõtte inimväärtus". Raamatu autori hinnangul on tänapäeva organisatsioonides juhtimise olulisim ülesanne inimese juhtimine varana. Lisa: Konverents

  9. Mida mõtleb professor Andrew Mayo? / Anne-Mari Ernesaks

    Index Scriptorium Estoniae

    Ernesaks, Anne-Mari

    2005-01-01

    PARE koordinaator tutvustab tuntud inimkapitali ideoloogi Andrew Mayo raamatut "Ettevõtte inimväärtus". Raamatu autori hinnangul on tänapäeva organisatsioonides juhtimise olulisim ülesanne inimese juhtimine varana. Lisa: Konverents

  10. PARPi-FL - a Fluorescent PARP1 Inhibitor for Glioblastoma Imaging

    Directory of Open Access Journals (Sweden)

    Christopher P. Irwin

    2014-05-01

    Full Text Available New intravital optical imaging technologies have revolutionized our understanding of mammalian biology and continue to evolve rapidly. However, there are only a limited number of imaging probes available to date. In this study, we investigated in mouse models of glioblastoma whether a fluorescent small molecule inhibitor of the DNA repair enzyme PARP1, PARPi-FL, can be used as an imaging agent to detect glioblastomas in vivo. We demonstrated that PARPi-FL has appropriate biophysical properties, low toxicity at concentrations used for imaging, high stability in vivo, and accumulates selectively in glioblastomas due to high PARP1 expression. Importantly, subcutaneous and orthotopic glioblastoma xenografts were imaged with high contrast clearly defining tumor tissue from normal surrounding tissue. This research represents a step toward exploring and developing PARPi-FL as an optical intraoperative imaging agent for PARP1 in the clinic.

  11. FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity

    OpenAIRE

    Rehana Qureshi; Onur Yildirim; Adeline Gasser; Christine Basmadjian; Qian Zhao; Jean-Philippe Wilmet; Laurent Désaubry; Nebigil, Canan G.

    2015-01-01

    Aims The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. Flavaglines are natural products that have both potent anticancer and cardioprotective properties. A synthetic analog of flavaglines, FL3, efficiently protects mice from the cardiotoxicity of doxorubicin. The mechanism underlying this cardioprotective effect has yet to be elucidated. Methods and Results Here, we show that FL3 binds to the scaffold proteins prohibitins (PHBs) and thus promotes th...

  12. 33 CFR 80.805 - Rock Island, FL to Cape San Blas, FL.

    Science.gov (United States)

    2010-07-01

    ... to Cape San Blas, FL. (a) A south-north line drawn from the Econfina River Light to the opposite shore. (b) A line drawn from Gamble Point Light to the southernmost extremity of Cabell Point. (c) A line drawn from St. Mark's Range Rear Light to St. Mark's Channel Light 11; thence to the...

  13. Therapy for Relapsed Multiple Myeloma: Guidelines From the Mayo Stratification for Myeloma and Risk-Adapted Therapy.

    Science.gov (United States)

    Dingli, David; Ailawadhi, Sikander; Bergsagel, P Leif; Buadi, Francis K; Dispenzieri, Angela; Fonseca, Rafael; Gertz, Morie A; Gonsalves, Wilson I; Hayman, Susan R; Kapoor, Prashant; Kourelis, Taxiarchis; Kumar, Shaji K; Kyle, Robert A; Lacy, Martha Q; Leung, Nelson; Lin, Yi; Lust, John A; Mikhael, Joseph R; Reeder, Craig B; Roy, Vivek; Russell, Stephen J; Sher, Taimur; Stewart, A Keith; Warsame, Rahma; Zeldenrust, Stephen R; Rajkumar, S Vincent; Chanan Khan, Asher A

    2017-04-01

    Life expectancy in patients with multiple myeloma is increasing because of the availability of an increasing number of novel agents with various mechanisms of action against the disease. However, the disease remains incurable in most patients because of the emergence of resistant clones, leading to repeated relapses of the disease. In 2015, 5 novel agents were approved for therapy for relapsed multiple myeloma. This surfeit of novel agents renders management of relapsed multiple myeloma more complex because of the occurrence of multiple relapses, the risk of cumulative and emergent toxicity from previous therapies, as well as evolution of the disease during therapy. A group of physicians at Mayo Clinic with expertise in the care of patients with multiple myeloma regularly evaluates the evolving literature on the biology and therapy for multiple myeloma and issues guidelines on the optimal care of patients with this disease. In this article, the latest recommendations on the diagnostic evaluation of relapsed multiple myeloma and decision trees on how to treat patients at various stages of their relapse (off study) are provided together with the evidence to support them. Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  14. Exploring the uncertainties of early detection results: model-based interpretation of mayo lung project

    Directory of Open Access Journals (Sweden)

    Berman Barbara

    2011-03-01

    Full Text Available Abstract Background The Mayo Lung Project (MLP, a randomized controlled clinical trial of lung cancer screening conducted between 1971 and 1986 among male smokers aged 45 or above, demonstrated an increase in lung cancer survival since the time of diagnosis, but no reduction in lung cancer mortality. Whether this result necessarily indicates a lack of mortality benefit for screening remains controversial. A number of hypotheses have been proposed to explain the observed outcome, including over-diagnosis, screening sensitivity, and population heterogeneity (initial difference in lung cancer risks between the two trial arms. This study is intended to provide model-based testing for some of these important arguments. Method Using a micro-simulation model, the MISCAN-lung model, we explore the possible influence of screening sensitivity, systematic error, over-diagnosis and population heterogeneity. Results Calibrating screening sensitivity, systematic error, or over-diagnosis does not noticeably improve the fit of the model, whereas calibrating population heterogeneity helps the model predict lung cancer incidence better. Conclusions Our conclusion is that the hypothesized imperfection in screening sensitivity, systematic error, and over-diagnosis do not in themselves explain the observed trial results. Model fit improvement achieved by accounting for population heterogeneity suggests a higher risk of cancer incidence in the intervention group as compared with the control group.

  15. Correlation of plasma FL expression with bone marrow irradiation dose.

    Directory of Open Access Journals (Sweden)

    Mary Sproull

    Full Text Available PURPOSE: Ablative bone marrow irradiation is an integral part of hematopoietic stem cell transplantation. These treatment regimens are based on classically held models of radiation dose and the bone marrow response. Flt-3 ligand (FL has been suggested as a marker of hematopoiesis and bone marrow status but the kinetics of its response to bone marrow irradiation has yet to be fully characterized. In the current study, we examine plasma FL response to total body and partial body irradiation in mice and its relationship with irradiation dose, time of collection and pattern of bone marrow exposure. MATERIALS/METHODS: C57BL6 mice received a single whole body or partial body irradiation dose of 1-8 Gy. Plasma was collected by mandibular or cardiac puncture at 24, 48 and 72 hr post-irradiation as well as 1-3 weeks post-irradiation. FL levels were determined via ELISA assay and used to generate two models: a linear regression model and a gated values model correlating plasma FL levels with radiation dose. RESULTS: At all doses between 1-8 Gy, plasma FL levels were greater than control and the level of FL increased proportionally to the total body irradiation dose. Differences in FL levels were statistically significant at each dose and at all time points. Partial body irradiation of the trunk areas, encompassing the bulk of the hematopoietically active bone marrow, resulted in significantly increased FL levels over control but irradiation of only the head or extremities did not. FL levels were used to generate a dose prediction model for total body irradiation. In a blinded study, the model differentiated mice into dose received cohorts of 1, 4 or 8 Gy based on plasma FL levels at 24 or 72 hrs post-irradiation. CONCLUSION: Our findings indicate that plasma FL levels might be used as a marker of hematopoietically active bone marrow and radiation exposure in mice.

  16. 77 FR 34210 - Amendment of Class E Airspace; Orlando, FL

    Science.gov (United States)

    2012-06-11

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; Orlando, FL AGENCY: Federal... Orlando, FL, as new Standard Instrument Approach Procedures have been developed at Orlando Executive... coordinates of Orlando Executive Airport, Orlando International Airport, and Kissimmee Municipal...

  17. FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity.

    Directory of Open Access Journals (Sweden)

    Rehana Qureshi

    Full Text Available The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. Flavaglines are natural products that have both potent anticancer and cardioprotective properties. A synthetic analog of flavaglines, FL3, efficiently protects mice from the cardiotoxicity of doxorubicin. The mechanism underlying this cardioprotective effect has yet to be elucidated.Here, we show that FL3 binds to the scaffold proteins prohibitins (PHBs and thus promotes their translocation to mitochondria in the H9c2 cardiomyocytes. FL3 induces heterodimerization of PHB1 with STAT3, thereby ensuring cardioprotection from doxorubicin toxicity. This interaction is associated with phosphorylation of STAT3. A JAK2 inhibitor, WP1066, suppresses both the phosphorylation of STAT3 and the protective effect of FL3 in cardiomyocytes. The involvement of PHBs in the FL3-mediated cardioprotection was confirmed by means of small interfering RNAs (siRNAs targeting PHB1 and PHB2. The siRNA knockdown of PHBs inhibits both phosphorylation of STAT3 and the cardioprotective effect of FL3.Activation of mitochondrial STAT3/PHB1 complex by PHB ligands may be a new strategy against doxorubicin-induced cardiotoxicity and possibly other cardiac problems.

  18. FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity

    Science.gov (United States)

    Gasser, Adeline; Basmadjian, Christine; Zhao, Qian; Wilmet, Jean-Philippe; Désaubry, Laurent; Nebigil, Canan G.

    2015-01-01

    Aims The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. Flavaglines are natural products that have both potent anticancer and cardioprotective properties. A synthetic analog of flavaglines, FL3, efficiently protects mice from the cardiotoxicity of doxorubicin. The mechanism underlying this cardioprotective effect has yet to be elucidated. Methods and Results Here, we show that FL3 binds to the scaffold proteins prohibitins (PHBs) and thus promotes their translocation to mitochondria in the H9c2 cardiomyocytes. FL3 induces heterodimerization of PHB1 with STAT3, thereby ensuring cardioprotection from doxorubicin toxicity. This interaction is associated with phosphorylation of STAT3. A JAK2 inhibitor, WP1066, suppresses both the phosphorylation of STAT3 and the protective effect of FL3 in cardiomyocytes. The involvement of PHBs in the FL3-mediated cardioprotection was confirmed by means of small interfering RNAs (siRNAs) targeting PHB1 and PHB2. The siRNA knockdown of PHBs inhibits both phosphorylation of STAT3 and the cardioprotective effect of FL3. Conclusion Activation of mitochondrial STAT3/PHB1 complex by PHB ligands may be a new strategy against doxorubicin-induced cardiotoxicity and possibly other cardiac problems. PMID:26536361

  19. Memorabilia: del grito de Córdoba al mayo francés

    OpenAIRE

    Biagini, Hugo Edgardo

    2009-01-01

    Al mayo francés puede asignársele una trascendencia semejante al de una verdadera revolución. No por ello cabe desconocer el carácter anticipador que tuvieron distintas proposiciones y efectividades de la juventud universitaria latinoamericana en los inicios del siglo XX, la cual, entre sus tantos aportes generacionales, ha defendido la ciudadanía supranacional y ha armado una legión de redes intelectuales y sindicales. Como el mismo Mayo francés, la Reforma Universitaria de 1918 cabe ser res...

  20. Spontaneous fission of superheavy nucleus $^{286}$Fl

    CERN Document Server

    Poenaru, Dorin N

    2016-01-01

    The decimal logarithm of spontaneous fission half-life of the superheavy nucleus $^{286}$Fl experimentally determined is $\\log_{10} T_f^{exp} (s) = -0.632$. We present a method to calculate the half-life based on the cranking inertia and the deformation energy, functions of two independent surface coordinates, using the best asymmetric two center shell model. In the first stage we study the statics. At a given mass asymmetry up to about $\\eta=0.5$ the potential barrier has a two hump shape, but for larger $\\eta$ it has only one hump. The touching point deformation energy versus mass asymmetry shows the three minima, produced by shell effects, corresponding to three decay modes: spontaneous fission, cluster decay and $\\alpha$~decay. The least action trajectory is determined in the plane $(R,\\eta)$ where $R$ is the separation distance of the fission fragments and $\\eta$ is the mass asymmetry. We may find a sequence of several trajectories one of which gives the least action. The parametrization with two deforma...

  1. 78 FR 14528 - Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and...

    Science.gov (United States)

    2013-03-06

    ... Energy Regulatory Commission Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On November 20, 2012, Mayo Hydropower, LLC (transferor) and Avalon Hydropower, LLC (transferee) filed an application for transfer of license...

  2. Prácticas de crianza y educación inicial en la etnia Mayo

    Directory of Open Access Journals (Sweden)

    Ángel Vera Noriega

    2010-01-01

    Full Text Available En el artículo se describen las características de las prácticas de crianza en una comunidad mayo y se realiza un análisis documental del Modelo de Educación Inicial no Escolarizada del CONAFE. Ello con la finalidad de contrastar los resultados de la práctica de crianza con las competencias esperadas de los padres y niños que asisten al programa y con base en ello, identificar la eficacia de la implementación del programa para la reproducción social en la etnia mayo. Participaron cincuenta madres y niños de la comunidad indígena mayo "El Júpare" ubicada en el municipio de Huatabampo, al sur de Sonora. Los instrumentos utilizados fueron Índice de Estrés Parental (Abidin, 1990, Interacción Padre-Hijo-Madre (Peña, 2004, Estimulación del Niño en el Hogar (Caldwell y Bradley, 1967 y Escala del Desarrollo Integral del niño (Atkin, 1987. En la evaluación del desarrollo, 54% de los niños presentan un desarrollo normal, 26% rrollo en riesgo y en 20% se detectan problemas. El programa de Educación Inicial no Escolarizado requiere de modificaciones sustantivas para responder a las prácticas de crianza que se desarrollan en la etnia mayo.

  3. Primary biliary cirrhosis : Dutch application of the Mayo model before and after orthotopic liver transplantation

    NARCIS (Netherlands)

    vanDam, GM; Verbaan, BW; Therneau, TM; Dickson, ER; Malinchoc, M; Murtaugh, PA; Huizenga, [No Value; Gips, CH

    1997-01-01

    Background/Aims: A retrospective study of primary biliary cirrhosis (PBC) was performed to study the Original Mayo Model for predicting survival by a Dutch data-set of patients, presentation of disease progression; assessment of liver transplantation, prediction of post-transplantation survival; and

  4. Matters of Priority: Herbert Mayo, Charles Bell and Discoveries in the Nervous System

    Science.gov (United States)

    Bradley, James

    2014-01-01

    Between 1822 and the late 1830s a highly personal priority dispute was fought between the celebrated surgeon and anatomist Sir Charles Bell and his ex-student Herbert Mayo. The dispute was over the motor and sensory functions of the Vth and VIIth cranial nerves. Over the course of the 1820s and the 1830s, the competing claims of Bell and Mayo were presented in newspapers, journals, and textbooks. But by the time of Bell’s death in 1842, Mayo had been discredited, a seemingly tragic footnote in the history of nervous discovery. And yet, with the benefit of hindsight, Bell’s case was at best disingenuous. His success was not due to any intrinsic scientific merit in his argument, but rather his ability to create a narrative that undermined the credibility of Mayo. However, only when Mayo’s public performances elided with Bell’s descriptions did this ploy succeed. As a result, the dispute illuminates the importance of credibility to the creation of an idealised scientific medical practitioner. PMID:25284895

  5. Hollymount Private Nursing and Retirement Home, Kilrush, Hollymount, Mayo.

    LENUS (Irish Health Repository)

    Naasan, M

    2012-05-01

    Information on the outcomes of ART treatments in Ireland is not readily available to Irish practitioners. The data for hospital affiliated clinics has been made available for many years and is included in the hospital reports. We present a 10-year analysis of the Irish ART results voluntarily reported by six out of seven IVF clinics. The data was collected from published ESHRE reports and from results (2007-8) not yet published. Data collected included: number of clinics and ART cycles, female age, clinical and multiple pregnancy rates and treatment complications. The clinical pregnancy rate per embryo transfer was 31.7% for IVF and 29.8% for ICSI. The proportion of singleton, twin and triplet deliveries for IVF and ICSI combined was 75%, 23.35% and 1.64%. The rate of ovarian hyperstimulation was 0.8%. ART practice in Ireland is safe, effective and responsible. Financial and societal savings could result from the introduction of state funded IVF with compulsory eSET where recommended.

  6. Panama City/U. of West FL spotted seatrout study

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These data sets contain raw and processed data, including collection location (bay) date, individual data for all trout collected, including FL, TL, whole weight,...

  7. D'Alton Community Nursing Unit, Claremorris, Mayo.

    LENUS (Irish Health Repository)

    Cahir, Caitriona

    2012-01-01

    There are concerns that proton pump inhibitors (PPI) are being over prescribed in both primary and secondary care. This study aims to establish potential cost savings in a community drug scheme for a one year period according to published clinical and cost-effective guidelines for PPI prescribing.

  8. Queen of Peace Nursing Home, Churchfield, Knock, Mayo.

    LENUS (Irish Health Repository)

    Holland, Deirdre M

    2015-04-01

    Medication reconciliation is a basic principle of good medicines management. With the establishment of the National Acute Medicines Programme in Ireland, medication reconciliation has been mandated for all patients at all transitions of care. The clinical pharmacist is widely credited as the healthcare professional that plays the most critical role in the provision of medication reconciliation services.

  9. Mac Bride Community Nursing Unit, St. Mary's Crescent, Westport, Mayo.

    LENUS (Irish Health Repository)

    Holland, Deirdre M

    2015-04-01

    Medication reconciliation is a basic principle of good medicines management. With the establishment of the National Acute Medicines Programme in Ireland, medication reconciliation has been mandated for all patients at all transitions of care. The clinical pharmacist is widely credited as the healthcare professional that plays the most critical role in the provision of medication reconciliation services.

  10. Flor de Mayo Eugenia, nueva variedad de frijol para riego y temporal en el centro de México Flor de Mayo Eugenia, new bean cultivar for irrigated and rainfall conditions in Central Mexico

    OpenAIRE

    Jorge Alberto Acosta Gallegos; Yanet Jiménez Hernández; Bertha María Sánchez García; Francisco M. Mendoza Hernández; María Guadalupe Herrera Hernández; Rafael A. Salinas Pérez; Mario González Chavira

    2010-01-01

    Dentro del frijol tipo Flor de Mayo, el subtipo 'media oreja' esta cobrando importancia en el norte-centro de México, éste es de tamaño mediano, forma alargada y color rosa atractivo. Se describe una nueva variedad de este tipo de frijol, Flor de Mayo Eugenia (FME). FME se derivó de una cruza interracial entre Flor de Mayo Anita (FMA) (raza Jalisco) y Rayado Rojo (raza Nueva Granada). El rendimiento promedio de FME en temporal varia de 0.8 a 2.0 t ha-1 y bajo riego el máximo rendimiento ha si...

  11. Evaluación positiva de medicamentos: marzo/abril/mayo 2016

    Directory of Open Access Journals (Sweden)

    R. Aparicio Hernández

    Full Text Available Se reseñan los medicamentos evaluados y con dictamen positivo por la comisión de expertos de la Agencia Española de Medicamentos y Productos Sanitarios o de la Agencia Europea del Medicamento hechos públicos en marzo, abril y mayo de 2016. Se trata de opiniones técnicas positivas previas a la autorización y puesta en el mercado del medicamento.

  12. Mayo Older Americans Normative Studies: Factor Analysis of an Expanded Neuropsychological Battery

    OpenAIRE

    Greenaway, Melanie C.; Smith, Glenn E.; Tangalos, Eric G.; Geda, Yonas E.; Ivnik, Robert J.

    2008-01-01

    The Mayo Cognitive Factor Scores were derived from a “core battery” consisting of the WAIS-R, WMS-R, and Auditory Verbal Learning Test. The present study sought to clarify the factor structure of an expanded neuropsychological battery in normal elderly controls. Confirmatory factor analysis was performed on the WAIS-III, WRAT-3 Reading, Boston Naming Test, Controlled Oral Word Association Test, Category Fluency, Rey-Osterrieth Complex Figure, Visual Form Discrimination, and Trail Making Test ...

  13. Evaluación positiva de medicamentos: marzo/abril/mayo 2015

    Directory of Open Access Journals (Sweden)

    R. Aparicio Hernández

    2015-09-01

    Full Text Available Se reseñan los medicamentos evaluados y con dictamen positivo por comisión de expertos de la Agencia Española de Medicamentos y Productos Sanitarios o de la Agencia Europea del Medicamento hechos públicos en marzo, abril y mayo de 2015. Se trata de opiniones técnicas positivas previas a la autorización y puesta en el mercado del medicamento.

  14. Investidura de doctor Honoris Causa de Gonzalo Torrente Ballester. Universidad de Salamanca, 23 de mayo de 1987

    OpenAIRE

    1987-01-01

    Cincuenta y cinco fotografías de la ceremonia de investidura de doctor Honoris Causa de Gonzalo Torrente Ballester. Acto celebrado en el Paraninfo de la Universidad de Salamanca el 23 de mayo de 1987.

  15. Penderecki: Konzert für Flöte und Kammerorchester; Eespere: Konzert für Flöte und Kammerorchester / Gero Schliess

    Index Scriptorium Estoniae

    Schliess, Gero

    1997-01-01

    Uuest heliplaadist "Penderecki: Konzert für Flöte und Kammerorchester; Eespere: Konzert für Flöte und Kammerorchester; Bartok: Suite paysanne hongroise für Flöte und Streichorchester. Estonian National Symphony Orchestra / Arvo Volmer". Signum/Note 1 CD X72-00 (WD:54'30")DDD

  16. Penderecki: Konzert für Flöte und Kammerorchester; Eespere: Konzert für Flöte und Kammerorchester / Gero Schliess

    Index Scriptorium Estoniae

    Schliess, Gero

    1997-01-01

    Uuest heliplaadist "Penderecki: Konzert für Flöte und Kammerorchester; Eespere: Konzert für Flöte und Kammerorchester; Bartok: Suite paysanne hongroise für Flöte und Streichorchester. Estonian National Symphony Orchestra / Arvo Volmer". Signum/Note 1 CD X72-00 (WD:54'30")DDD

  17. 76 FR 68117 - Television Broadcasting Services; Panama City, FL

    Science.gov (United States)

    2011-11-03

    ...-140; RM-11683, DA 11-1735] Television Broadcasting Services; Panama City, FL AGENCY: Federal... Gray Television Licensee, LLC (``Gray''), the licensee of WJHG-TV, channel 7, Panama City, Florida...)(A). List of Subjects in 47 CFR Part 73 Television. Federal Communications Commission. Barbara...

  18. Danskhed er pizza, kebab og flæskesteg

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2010-01-01

    Dannebrog. Kongehuset. Flæskesteg. Folkeskolen. Fodbold og øl. En lang række symboler og fortællinger kendetegner danskhed, men det er en myte, at danskerne er en homogen gruppe, fortæller professor Richard Jenkins....

  19. Antibacterial activity and therapeutic efficacy of Fl-PRPRPL-5, a cationic amphiphilic polyproline helix, in a mouse model of staphylococcal skin infection

    Directory of Open Access Journals (Sweden)

    Thangamani S

    2015-10-01

    Full Text Available Shankar Thangamani,1 Manish Nepal,2 Jean Chmielewski,2 Mohamed N Seleem11Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN, USA; 2Department of Chemistry, Purdue University, West Lafayette, IN, USAAbstract: The antibacterial activities and therapeutic efficacy of the cationic, unnatural proline-rich peptide Fl-PRPRPL-5 were evaluated against multidrug-resistant Staphylococcus aureus in a mouse model of skin infection. Fl-PRPRPL-5 showed potent activity against all clinical isolates of S. aureus tested, including methicillin- and vancomycin-resistant S. aureus (MRSA and VRSA, respectively. Fl-PRPRPL-5 was also superior in clearing established in vitro biofilms of S. aureus and Staphylococcus epidermidis, compared with the established antimicrobials mupirocin and vancomycin. Additionally, topical treatment of an MRSA-infected wound with Fl-PRPRPL-5 enhanced wound closure and significantly reduced bacterial load. Finally, 0.5% Fl-PRPRPL-5 significantly reduced the levels of the inflammatory cytokines tumor necrosis factor-α (TNF-α, interleukin-6 (IL-6, and interleukin-1 beta (IL-1β in wounds induced by MRSA skin infection. In conclusion, the results of this study suggest the potential application of Fl-PRPRPL-5 in the treatment of staphylococcal skin infections.Keywords: antimicrobial peptides, Staphylococcus aureus, biofilms, anti-inflammatory, skin infection

  20. Antibacterial activity and therapeutic efficacy of Fl-P(R)P(R)P(L)-5, a cationic amphiphilic polyproline helix, in a mouse model of staphylococcal skin infection.

    Science.gov (United States)

    Thangamani, Shankar; Nepal, Manish; Chmielewski, Jean; Seleem, Mohamed N

    2015-01-01

    The antibacterial activities and therapeutic efficacy of the cationic, unnatural proline-rich peptide Fl-P(R)P(R)P(L)-5 were evaluated against multidrug-resistant Staphylococcus aureus in a mouse model of skin infection. Fl-P(R)P(R)P(L)-5 showed potent activity against all clinical isolates of S. aureus tested, including methicillin- and vancomycin-resistant S. aureus (MRSA and VRSA, respectively). Fl-P(R)P(R)P(L)-5 was also superior in clearing established in vitro biofilms of S. aureus and Staphylococcus epidermidis, compared with the established antimicrobials mupirocin and vancomycin. Additionally, topical treatment of an MRSA-infected wound with Fl-P(R)P(R)P(L)-5 enhanced wound closure and significantly reduced bacterial load. Finally, 0.5% Fl-P(R)P(R)P(L)-5 significantly reduced the levels of the inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β) in wounds induced by MRSA skin infection. In conclusion, the results of this study suggest the potential application of Fl-P(R)P(R)P(L)-5 in the treatment of staphylococcal skin infections.

  1. Antibacterial activity and therapeutic efficacy of Fl-PRPRPL-5, a cationic amphiphilic polyproline helix, in a mouse model of staphylococcal skin infection

    Science.gov (United States)

    Thangamani, Shankar; Nepal, Manish; Chmielewski, Jean; Seleem, Mohamed N

    2015-01-01

    The antibacterial activities and therapeutic efficacy of the cationic, unnatural proline-rich peptide Fl-PRPRPL-5 were evaluated against multidrug-resistant Staphylococcus aureus in a mouse model of skin infection. Fl-PRPRPL-5 showed potent activity against all clinical isolates of S. aureus tested, including methicillin- and vancomycin-resistant S. aureus (MRSA and VRSA, respectively). Fl-PRPRPL-5 was also superior in clearing established in vitro biofilms of S. aureus and Staphylococcus epidermidis, compared with the established antimicrobials mupirocin and vancomycin. Additionally, topical treatment of an MRSA-infected wound with Fl-PRPRPL-5 enhanced wound closure and significantly reduced bacterial load. Finally, 0.5% Fl-PRPRPL-5 significantly reduced the levels of the inflammatory cytokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β) in wounds induced by MRSA skin infection. In conclusion, the results of this study suggest the potential application of Fl-PRPRPL-5 in the treatment of staphylococcal skin infections. PMID:26543355

  2. Resumen de sismos reportados por los meses de mayo, junio, julio, agosto setiembre 2003

    OpenAIRE

    Costa Rica. Comisión Nacional de Prevención de Riesgos y Atención de Emergencias

    2003-01-01

    Se presenta un resumen de datos recolectados sobre los sismos reportados en Costa Rica, durante el periodo comprendido entre mayo y setiembre del 2003. Comprende el mes, la fecha, la hora, la magnitud, la ubicación, la profundidad, los sitios donde fue sentido y su origen. Incluye un mapa con la ubicación de los sismos reportados It presents a summary of the data collected about the earthquakes reported in Costa Rica between May and September 2003. It includes month, date, time, magnitude...

  3. Relaciones hídricas y temperaturas altas en frijol del tipo "flor de mayo"

    OpenAIRE

    2010-01-01

    Se estudió el efecto del déficit hídrico del suelo y temperatura alta del aire en las relaciones hídricas y temperatura del dosel del cultivo (Tc), rendimiento de semilla (RS) y sus componentes en 8 variedades de frijol del tipo ?Flor de Mayo? (FM) y una variedad criolla. Se realizaron 3 experimentos de campo; Montecillo en riego (MR) con la aplicación de agua de la siembra a la madurez, Montecillo en secano (MS) con la lluvia como fuente única de humedad y Celaya en secano (CS) con lluvia y ...

  4. Resumen de sismos reportados por los meses de mayo, junio, julio, agosto setiembre 2003

    Directory of Open Access Journals (Sweden)

    Costa Rica. Comisión Nacional de Prevención de Riesgos y Atención de Emergencias

    2003-09-01

    Full Text Available Se presenta un resumen de datos recolectados sobre los sismos reportados en Costa Rica, durante el periodo comprendido entre mayo y setiembre del 2003. Comprende el mes, la fecha, la hora, la magnitud, la ubicación, la profundidad, los sitios donde fue sentido y su origen. Incluye un mapa con la ubicación de los sismos reportados It presents a summary of the data collected about the earthquakes reported in Costa Rica between May and September 2003. It includes month, date, time, magnitude, location, depth, places where it was felt and origin. It includes a map with the location of the earthquakes reported

  5. Salida de campo a Fuensaldaña (Valladolid) el 29 de mayo de 1953

    OpenAIRE

    Valverde Gómez, José Antonio, 1926-2003

    2008-01-01

    Salida de campo a Fuensaldaña (Valladolid) el 29 de mayo de 1953, de la que se anotaron observaciones sobre una Malpolon monspessulanus (Culebra bastarda, llamada Coleopeltis mouspessulanus por el autor) hallada muerta, los siguientes mamíferos: Apodemus sp. (Ratón), Crocidura sp. (Musaraña), Eliomys quercinus (Lirón careto, también llamado Ratón ojalbo por el autor) y "Pytimis" (llamado así por el autor, siendo posiblemente el actual género Microtus), hallados dentro de egagrópilas de Lechu...

  6. Del testimonio al Best-seller en la Plaza de Mayo

    OpenAIRE

    Araujo, Helena; Pontificia Universidad Javeriana, Bogotá

    2014-01-01

    Con vida los trajimos, con vida los queremos, gritaban las mujeres en la Plaza de Mayo durante la dictadura militar argentina, "haciendo de la maternidad un derecho político y utilizando el cuerpo maternal como una táctica contra el poder fascista" (Guerra, 1989: 158). Desde los años setenta, su terca, desesperada, heroica denuncia, constituiría un referente en la producción textual, no sólo con respecto a obras documentales, sino a novelas como la recientemente publicada por Elsa Osorio. A v...

  7. Three-dimensional Physical Modeling: Applications and Experience at Mayo Clinic.

    Science.gov (United States)

    Matsumoto, Jane S; Morris, Jonathan M; Foley, Thomas A; Williamson, Eric E; Leng, Shuai; McGee, Kiaran P; Kuhlmann, Joel L; Nesberg, Linda E; Vrtiska, Terri J

    2015-01-01

    Radiologists will be at the center of the rapid technologic expansion of three-dimensional (3D) printing of medical models, as accurate models depend on well-planned, high-quality imaging studies. This article outlines the available technology and the processes necessary to create 3D models from the radiologist's perspective. We review the published medical literature regarding the use of 3D models in various surgical practices and share our experience in creating a hospital-based three-dimensional printing laboratory to aid in the planning of complex surgeries.

  8. Falls prevention at Mayo Clinic Rochester: a path to quality care.

    Science.gov (United States)

    Sulla, Stephanie J; McMyler, Eileen

    2007-01-01

    Falls prevention is a complex problem. Following in the footsteps of an earlier fall prevention team, the Safe Landings Fall Prevention Team used many strategies for implementing a fall prevention/reduction program. The tactics we used to prevent falls combined with the adoption of a fall assessment risk model are shared.

  9. Animal-assisted therapy at Mayo Clinic: The time is now.

    Science.gov (United States)

    Creagan, Edward T; Bauer, Brent A; Thomley, Barbara S; Borg, Jessica M

    2015-05-01

    The animal-human bond refers to an emotional, almost existential, relationship between animals and people. From the time of antiquity, domestic animals were an important source of economic vitality, but with the changing cultural landscape, the companion animal has become a faithful friend. Overwhelming anecdotal evidence supports the healing power of this relationship. We summarize the emerging literature on the neurobiochemical and cardiovascular benefits of companion pet ownership. We address the peer-reviewed data from myriad journal articles assessing the impact of the companion animal on the quality and often the length of life of select patients.

  10. Culture-Proven Thorn-Associated Infections in Arizona: 10-Year Experience at Mayo Clinic.

    Science.gov (United States)

    Simmons, Sierra C; Budavari, Adriane I; Kusne, Shimon; Zhang, Nan; Vikram, Holenarasipur R; Blair, Janis E

    2017-01-01

    Thorn injuries are common in the desert Southwest; however, the frequency and microbiology of thorn-associated infections have not been systematically described. Most information comes from case reports describing infections from atypical or environmental microorganisms. Our aim was to summarize the spectrum of thorn-associated infections. We conducted a retrospective review of electronic health records for patients presenting to our institution from January 1, 2005 to December 31, 2014 for treatment of thorn-associated injuries and then focused on the patients with cultures. Of 2758 records reviewed, 1327 patients had thorn-associated injuries; however, only 58 (4.4%) had cultures. Of these patients, 37 (64%) had positive findings; 5 had polymicrobial infection. The most commonly identified organisms were Staphylococcus aureus (n = 22, 59.0%) and coagulase-negative Staphylococcus species (n = 8, 21.6%). Other pathogens included Nocardia species (n = 3, 8.1%), Streptococcus species (n = 2, 5.4%), Gram-negative bacteria (n = 2, 5.4%), Aspergillus species (n = 2, 5.4%), Paecilomyces lilacinus (n = 1, 2.7%), and Candida species (n = 1, 2.7%). There were no infections caused by Pantoea agglomerans, Sporothrix schenckii, or Coccidioides spp. In contrast to most published case reports, we found that typical cutaneous microorganisms, such as Staphylococcus species, caused the majority of culture-positive, thorn-related infections.

  11. Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of GN.

    Science.gov (United States)

    Sethi, Sanjeev; Haas, Mark; Markowitz, Glen S; D'Agati, Vivette D; Rennke, Helmut G; Jennette, J Charles; Bajema, Ingeborg M; Alpers, Charles E; Chang, Anthony; Cornell, Lynn D; Cosio, Fernando G; Fogo, Agnes B; Glassock, Richard J; Hariharan, Sundaram; Kambham, Neeraja; Lager, Donna J; Leung, Nelson; Mengel, Michael; Nath, Karl A; Roberts, Ian S; Rovin, Brad H; Seshan, Surya V; Smith, Richard J H; Walker, Patrick D; Winearls, Christopher G; Appel, Gerald B; Alexander, Mariam P; Cattran, Daniel C; Casado, Carmen Avila; Cook, H Terence; De Vriese, An S; Radhakrishnan, Jai; Racusen, Lorraine C; Ronco, Pierre; Fervenza, Fernando C

    2016-05-01

    Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aim of standardizing the kidney biopsy report of GN. On the basis of etiology/pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basement membrane GN, monoclonal Ig GN, and C3 glomerulopathy. The pathogenesis-based classification forms the basis of the kidney biopsy report. To standardize the report, the diagnosis consists of a primary diagnosis and a secondary diagnosis. The primary diagnosis should include the disease entity/pathogenic type (if disease entity is not known) followed in order by pattern of injury (mixed patterns may be present); score/grade/class for disease entities, such as IgA nephropathy, lupus nephritis, and ANCA GN; and additional features as detailed herein. A pattern diagnosis as the sole primary diagnosis is not recommended. Secondary diagnoses should be reported separately and include coexisting lesions that do not form the primary diagnosis. Guidelines for the report format, light microscopy, immunofluorescence microscopy, electron microscopy, and ancillary studies are also provided. In summary, this consensus report emphasizes a pathogenesis-based classification of GN and provides guidelines for the standardized reporting of GN.

  12. «Mayo Teatral 2008»: o teatro contemporâneo em Havana – Cuba

    Directory of Open Access Journals (Sweden)

    Marcos Antônio Alexandre

    2011-10-01

    Full Text Available Resumo: Este artigo traz para discussão o panorama artístico cubano a partir da análise crítica de alguns textos espetaculares que foram apresentados no evento 8ª Temporada de Teatro Latinoamericano y Caribeño Mayo Teatral 2008. Para esta reflexão, são utilizadas as contribuições da semiótica teatral e são discutidas temáticas relacionadas, entre outras questões, à memória, à cultura cubana e afrocubana e às identidades.  Palavras-chave: Teatro; semiótica teatral; Cuba; memória; cultura; identidade.Resumen: Este artículo se propone a discutir el panorama artístico cubano a través del análisis de algunos textos espectaculares que fueron presentados en el evento 8ª Temporada de Teatro Latinoamericano y Caribeño – Mayo Teatral 2008. Para esta reflexión son utilizados los aportes de la semiótica teatral y son discutidas temáticas relacionadas, entre otras cuestiones, a la memoria, a la cultura cubana y afro-cubana y a las identidades.Palabras-clave: Teatro; semiótica teatral; Cuba; memoria; cultura; identidad.Keywords: Theater; theater semiotics; Cuba; memory; culture; identity.

  13. Fracturas del tercio medio facial: experiencia en el Hospital Nacional Dos de Mayo, 1999 - 2009

    Directory of Open Access Journals (Sweden)

    Francisco Avello Canisto

    2013-04-01

    Full Text Available Introducción: Correspondiendo a una patología frecuente en la especialidad de cabeza, cuello y máxilo-facial, consecuencia de traumatismos severos, es importante determinar las características de las fracturas del tercio medio facial, para su manejo. Objetivo: Determinar la presentación de las fracturas del tercio medio facial por edad, sexo, agente causal. Diseño: Estudio observacional descriptivo. Lugar: Servicio de Cirugía de Cabeza, Cuello y Máxilo-Facial del Hospital Nacional Dos de Mayo, Lima, Perú. Participantes: Pacientes con fractura del tercio medio facial. Intervenciones: Recolección de datos registrados en las historias clínicas, entre junio 1999 y mayo 2009. Principales medidas de resultados: Edad, sexo, agente causal y clasificación. Resultados: De 471 pacientes, 83% fue de sexo masculino, 72,5% tenía entre 21 y 40 años de edad, 48% fue por accidentes de tránsito y 25% por robos; 83% correspondió solamente a fracturas del tercio medio y 88% a trazo unilateral. Conclusiones: Las fracturas del tercio medio facial son las más frecuentes de la región facial; el diagnóstico clínico depende de la estructura afectada. Se debe actuar oportunamente para evitar secuelas y complicaciones.

  14. Study of Rayleigh-backscattering induced coherence collapse in an asymmetric DFB FL sensor

    Science.gov (United States)

    Liu, Wen; Ma, Lina; Hu, Zhengliang; Feng, Ying; Yang, Huayong

    2016-09-01

    Rayleigh-back scattering induced coherence collapse of an asymmetric distributed feedback fiber laser (DFB FL) sensor is investigated using a composite cavity model. The coherence collapse threshold condition of the asymmetric DFB FL sensor is measured. The DFB FL sensor shows different dynamic behaviors in different pump configurations. According to the asymmetric behavior to the external optical feedback, a novel method to find the actual phase shift position of the asymmetric DFB FL sensor is presented.

  15. Social Bilingualism and FL Teaching: The Case of Catalan

    Directory of Open Access Journals (Sweden)

    Amalia Llombart-Huesca

    2005-01-01

    Full Text Available Learning a foreign language entails acquiring competence on what is expected socially and culturally by users of the target language. However, in this paper I show how adoption of the sociolinguistics norms of certain languages conflicts with some principles of Foreign Language (FL instruction and Communicative Language Teaching. This paper focuses on a group of languages that share a particular sociolinguistic context: "languages without a country" or regional languages, such as Catalan, Basque or Irish, among others. I show how some phenomena typical in bilingual communities, such as diglossia, code-switching, language interference and language attitudes present a challenge in some areas of FL instruction, such as creation of task-based activities, syllabus design, dealing with language registers and dialects in the classroom, and integration of language and culture. This study suggests the needs for further research in the area in which sociolinguistic issues of languages in their homeland interact with the teaching of those languages as FLs.

  16. 77 FR 22667 - Amendment of Restricted Area R-2917, De Funiak Springs, FL

    Science.gov (United States)

    2012-04-17

    ... Funiak Springs, FL AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This... vertical dimensions of restricted area R-2917, De Funiak Springs, FL, which surrounds an FPS-85 radar... dimensions of R-2917, De Funiak Springs, FL, from the current 2.5-nautical mile radius circle, extending...

  17. 78 FR 17085 - Amendment of Multiple Restricted Areas; Eglin AFB, FL

    Science.gov (United States)

    2013-03-20

    ... within the Eglin Range Complex was changed from ``Armament Center'' to ``Test Wing.'' This action is an..., FL, from ``U.S. Air Force, Commander, Air Armament Center, Eglin AFB, FL,'' to ``U.S. Air Force... the words ``Using agency. U.S. Air Force, Commander, Air Armament Center, Eglin AFB, FL,''...

  18. 78 FR 25383 - Amendment of Class E Airspace; West Palm Beach, FL

    Science.gov (United States)

    2013-05-01

    ... Beach County Park Airport, West Palm Beach, FL (78 FR 6258). Interested parties were invited to... Federal Aviation Administration 14 CFR Part 71 Amendment of Class E Airspace; West Palm Beach, FL AGENCY... Airspace in the West Palm Beach, FL area, as new Standard Instrument Approach Procedures (SIAPs) have...

  19. Cross-Cultural Perspective of FL Teaching and Learning in the Polish Context

    Science.gov (United States)

    Sobkowiak, Pawel

    2012-01-01

    This study examines whether learners' capacity to use a foreign language (FL) successfully in the global world is developed in the FL classroom in Polish high schools. The article reports results of the quantitative research which aimed at assessing whether and to what extent homogeneous FL classes in Poland are conducive to developing learners'…

  20. 77 FR 21662 - Amendment of Class D Airspace; Cocoa Beach, FL

    Science.gov (United States)

    2012-04-11

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D Airspace; Cocoa Beach, FL AGENCY... amends Class D airspace at Cape Canaveral Skid Strip, Cocoa Beach, FL, by correcting the geographic... of Cape Canaveral Skid Strip, Cocoa Beach, FL. Also, the geographic coordinates for the airport...

  1. 76 FR 30298 - Proposed Amendment of Class E Airspace; Cocoa, FL

    Science.gov (United States)

    2011-05-25

    ... Class E Airspace; Cocoa, FL AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed rulemaking (NPRM). SUMMARY: This action proposes to amend Class E Airspace at Cocoa, FL, as the... at Merritt Island Airport, Cocoa, FL. Airspace reconfiguration is necessary due to...

  2. 77 FR 28243 - Amendment of Class D Airspace; Cocoa Beach, FL

    Science.gov (United States)

    2012-05-14

    ... Federal Aviation Administration 14 CFR Part 71 Amendment of Class D Airspace; Cocoa Beach, FL AGENCY... in the Federal Register on April 11, 2012 that amends Class D airspace at Cocoa Beach, FL. DATES... D airspace at Cape Canaveral Skid Strip, Cocoa Beach, FL. A typographical error was made in...

  3. Deluges of Grandeur: Water, Territory, and Power on Northwest Mexico’s Río Mayo, 1880-1910

    OpenAIRE

    Jeffrey M. Banister

    2011-01-01

    Northwest Mexico’s irrigation landscape, known today as El Distrito de Riego 038, or El Valle del Mayo, issues from historical struggles to build an official order out of a diverse world of signs, symbols, processes, places, and peoples. It is the ancestral home of the Yoreme (Mayo), an indigenous group for whom colonisation and agricultural development have meant the loss of autonomy and of the seasonal mobility required to subsist in an arid land. It is also the birthplace of President Álva...

  4. Optimierung von ionischen Flüssigkeiten als selektive Zusatzstoffe in der thermischen Trenntechnik

    OpenAIRE

    Jork, Carsten

    2006-01-01

    Ziel dieser Arbeit ist die Klärung der Frage, in welchen Fällen sich Vertreter der ionischen Flüssigkeiten (IL) aus thermodynamischer Sicht als selektive Zusatzstoffe in der thermischen Trenntechnik einsetzen lassen sowie die Entwicklung einer Methode zur Auswahl von wirksamen ionischen Zusatzstoffen. Deshalb wird die Wirkungsweise ionischer Flüssigkeiten auf die für die Destillation und Extraktion maßgeblichen Dampf-Flüssig-Phasengleichgewichte (Vapor Liquid Equilibrium: VLE) bzw. Flüssig-Fl...

  5. Mayo Adhesive Probability Score Is an Independent Computed Tomography Scan Predictor of Adherent Perinephric Fat in Open Partial Nephrectomy.

    Science.gov (United States)

    Martin, Logan; Rouviere, Olivier; Bezza, Riadh; Bailleux, Jérôme; Abbas, Fatima; Schott-Pethelaz, Anne-Marie; Ruffion, Alain; Paparel, Philippe

    2017-05-01

    To evaluate predictive radiological elements for adherent perinephric fat (APF) and the Mayo adhesive probability (MAP) score in the setting of open partial nephrectomy, and to assess their reproducibility. We performed a retrospective case-control study involving 86 patients who had open partial nephrectomies performed by a single surgeon between January 1, 2009 and April 1, 2015. Radiological elements were assessed by 4 readers blinded to patient APF status. Univariate and multivariate analyses were performed for all radiological and clinical factors. Reproducibility was analyzed using agreement coefficients. On univariate analysis for radiological findings, lateral and posterior fat thickness (odds ratio [OR]: 1.084 [1.033, 1.138], P < .001), stranding (OR: 2.179 [1.431, 3.318], P < .001), -80 HU fat area, and the MAP score (OR: 1.797 [1.332, 2.424], P < .001) were predictive of APF. On multivariate analysis, only age and the MAP score remained statistically significant (OR: 1.060 [1.005, 1.118], P = .03; and OR: 1.560 [1.137, 2.139], P = .0058, respectively). The reproducibility of the MAP score was fair (AC1 = 0.367 and kappa F = 0.353), as was that of stranding (AC1 = 0.499, kappa F = 0.376). The agreement was important if we defined a "low" (0 to 3) or "high" (4 or 5) score (AC1 = 0.706 and kappa F = 0.681). The MAP score was the element that best predicted APF in our study, although its reproducibility among our readers was only fair. The agreement becomes important if we defined "low or high" score. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. El poder de la palabra: o la "mirada inversa" de Michel de Certeau sobre el mayo francés

    Directory of Open Access Journals (Sweden)

    Luis Ignacio Sierra Gutiérrez

    2008-01-01

    Full Text Available Este comentario pretende reflexionar sobre la "mirada inversa" de Michel de Certeau, a partir de la "toma de la palabra" como eje central de las acciones simbólicas de mayo del 68 y su resonancia en la realidad sociopolítica de la nación colombiana.

  7. Incisional hernia recurrence following 'vest-over-pants' or vertical mayo repair of primary hernias of the midline

    NARCIS (Netherlands)

    R.W. Luijendijk; M.H.M. Lemmen (M. H M); W.C.J. Hop (Wim); J.C.J. Wereldsma

    1997-01-01

    textabstractA series of 68 primary midline incisional hernias with a vertical Mayo repair was evaluated retrospectively. Patients without documented hernia recurrence following this repair were invited for physical examination. Life- table methods were used for statistical analysis. The 1-, 3-, 5-,

  8. Major clinical events, signs and severity assessment scores related to actual survival in patients who died from primary biliary cirrhosis. A long-term historical cohort study

    NARCIS (Netherlands)

    van Dam, GM; Gips, CH; Reisman, Y; Maas, KW; Purmer, IM; Huizenga, [No Value; Verbaan, BW

    1999-01-01

    BACKGROUND/AIMS: One of the prognostic methods for survival in primary biliary cirrhosis (PBC) is the Mayo model, with a time-scale limited to 7 years. The aim of our study was to assess how major clinical events, signs, several severity assessment methods and Mayo survival probabilities fit in with

  9. Petrology of suprasubductive mantle xenoliths from Estancia Sol De Mayo (Central Patagonia, Argentina)

    Science.gov (United States)

    Melchiorre, M.; Coltorti, M.; Gregoire, M.; Benoit, M.

    2012-04-01

    A new suite of mantle xenoliths from Estancia Sol de Mayo (Patagonia) has been investigated. They were entrained in alkaline lavas from the south western sector of Meseta Lago Buenos Aires. Trace element abundances of these lavas are well comparable with those of the main and post-plateau lavas from the Triple Junction Province and resemble those of OIB. Xenoliths are spinel-bearing harzburgites and dunites, with minor lherzolites and one wehrlite. They are characterized by a coarse grained protogranular texture and devoid of modal metasomatic features and hydrated minerals. They show two texturally different clinopyroxenes. One is protogranular (cpx1), while the second surrounds, and is genetically related to, spinel (cpx2). Three different types of orthopyroxenes are also recognized: the first one is represented by large protogranular crystals with exsolution lamellae (opx1), the second one by small clean and undeformed grains without exsolution lamellae (opx2) and the last one occurs as small grains filling veins (opx3). Major element compositions of both clinopyroxenes and orthopyroxenes highlight two different trends. The first one is characterized by high Al2O3 (high-Al trend) content at almost constant mg# [MgO/(MgO+FeO) mol %], while the second shows a slight increase in Al2O3 (low-Al trend) content with decreasing mg#. Trace element contents of cpx are enriched in LREE and characterized by prominent to slightly negative Nb, Zr and Ti anomalies. No differences are observed between cpx1 and cpx2. The three groups of orthopyroxenes are variably depleted in LREE, with opx1 and opx2 always showing prominent to slightly negative Ti and Zr anomalies, while opx3 is characterized by a prominent positive Zr anomaly. Al2O3 in cpx is inversely correlated with LREE and LILE suggesting that a refertilization event occur within the upper mantle beneath Estancia Sol de Mayo. The most likely melt which can account for this event has a tholeiitic affinity, as supported by i

  10. An Exo-Jupiter candidate in the eclipsing binary FL Lyr

    Science.gov (United States)

    Kozyreva, V. S.; Bogomazov, A. I.; Demkov, B. P.; Zotov, L. V.; Tutukov, A. V.

    2015-11-01

    Light curves of the eclipsing binary FL Lyr acquired by the Kepler space telescope are analyzed. Eclipse timing measurements for FL Lyr testify to the presence of a third body in the system. Preliminary estimates of its mass and orbital period are ≳2MJ and ≳7 yrs. The times of primary minimum in the light curve of FL Lyr during the operation of the Kepler mission are presented.

  11. An Exo-Jupiter Candidate in the Eclipsing Binary FL Lyr

    CERN Document Server

    Kozyreva, V S; Demkov, B P; Zotov, L V; Tutukov, A V

    2015-01-01

    Light curves of the eclipsing binary FL Lyr acquired by the Kepler space telescope are analyzed. Eclipse timing measurements for FL Lyr testify to the presence of a third body in the system. Preliminary estimates of its mass and orbital period are > 2M_Jupiter and > 7 yrs. The times of primary minimum in the light curve of FL Lyr during the operation of the Kepler mission are presented.

  12. El movimiento estudiantil reformista frente al primer episodio de la 'laica o libre' [mayo de 1956

    Directory of Open Access Journals (Sweden)

    Juan Sebastián Califa

    2009-11-01

    Full Text Available En mayo de 1956 se libró en la Argentina el primer episodio del conflicto "laica o libre". Así se llamó al enfrentamiento entre reformistas, contrarios al artículo 28 del decreto-ley 6.403 que permitía a las universidades privadas otorgar títulos habilitantes, y católicos favorables al mismo. En este contexto, se registró un ascendente proceso de tomas estudiantiles de secundarios y universidades. El conflicto le costó el cargo al católico ministro de Educación nacional Atilio Dell'Oro Maini y a los rectores de las universidades de Buenos Aires [UBA] y de Córdoba [UNC]. No obstante las tensas implicancias que el mismo deparó dentro del gobierno de la autoproclamada "Revolución Libertadora", poco se conoce sobre él. En este artículo iniciaré su estudio. Para ello reconstruiré los hechos a través de los diarios La Nación y La Prensa, entre otras fuentes y bibliografía. Particularmente concentraré mi atención en el estudiantado reformista de la UBA

  13. Polyphenolic substrates and dyes degradation by yeasts from 25 de Mayo/King George Island (Antarctica).

    Science.gov (United States)

    Rovati, José I; Pajot, Hipólito F; Ruberto, Lucas; Mac Cormack, Walter; Figueroa, Lucía I C

    2013-11-01

    Antarctica offers a range of extreme climatic conditions, such as low temperatures, high solar radiation and low nutrient availability, and constitutes one of the harshest environments on Earth. Despite that, it has been successfully colonized by ’cold-loving’ fungi, which play a key role in decomposition cycles in cold ecosystems. However, knowledge about the ecological role of yeasts in nutrient or organic matter recycling/mineralization remains highly fragmentary. The aim of this work was to study the yeast microbiota in samples collected on 25 de Mayo/King George Island regarding the scope of their ability to degrade polyphenolic substrates such as lignin and azo dyes. Sixty-one yeast isolates were obtained from 37 samples, including soil, rocks, wood and bones. Molecular analyses based on rDNA sequences revealed that 35 yeasts could be identified at the species level and could be classified in the genera Leucosporidiella, Rhodotorula, Cryptococcus, Bullera and Candida. Cryptococcus victoriae was by far the most ubiquitous species. In total, 33% of the yeast isolates examined showed significant activity for dye decolorization, 25% for laccase activity and 38% for ligninolytic activity. Eleven yeasts did not show positive activity in any of the assays performed and no isolates showed positive activity across all tested substrates. A high diversity of yeasts were isolated in this work, possibly including undescribed species and conspicuous Antarctic yeasts, most of them belonging to oligotrophic, slow-growing and metabolically diverse basidiomycetous genera.

  14. Académico Fernando Serpa Flórez

    Directory of Open Access Journals (Sweden)

    José Felix Patiño Restrepo

    2001-12-01

    Full Text Available

    Brillante, generoso, noble, escritor prolífico, un completo caballero, Fernando Serpa Flórez fue el prototipo del médico intelectual, humanista y humanitario. Su vocación por la salud pública lo llevó a ocupar altos cargos en el ramo: Secretario General del Ministerio de Salud, Secretario de Salud de Bogotá, Director del Instituto Nacional de Salud, Director del Ministerio de Salud y Ministro Encargado de Salud. Como Asesor de la Organización Mundial de la Salud, trabajó en Afganistán en el programa de erradicación de la viruela.
    Fue médico, jefe de Ecopetrol. Desde su elevada posición como Magistrado del Tribunal Nacional de Etica Médica, y con el ejemplo de su vida personal, como uno de los miembros más distinguidos de la Academia Nacional de Medicina, Fernando Serpa Flórez ocupa un lugar de particular distinción en la historia
    contemporánea de la medicina colombiana.

    Tuve el privilegio de su amistad por más de medio siglo, como condiscípulo en la Facultad de Medicina de la Universidad Nacional y luego a través de los años compartiendo afectos e intereses. Me acompaño con talento, lealtad y dedicación como Director del Ministerio cuando ocupé el cargo de Ministro en el Gobierno del eximio Presidente Guillermo León Valencia. Para quienes lo conocimos de cerca, este vástago de
    una brillante familia de médicos, sobrevivirá en nuestra memoria y en sus obras...

  15. The December 2012 Mayo River debris flow triggered by Super Typhoon Bopha in Mindanao, Philippines: lessons learned and questions raised

    Science.gov (United States)

    Rodolfo, Kelvin S.; Lagmay, A. Mahar F.; Eco, Rodrigo C.; Herrero, Tatum Miko L.; Mendoza, Jerico E.; Minimo, Likha G.; Santiago, Joy T.

    2016-12-01

    Category 5 Super Typhoon Bopha, the world's worst storm of 2012, formed abnormally close to the Equator, and its landfall on Mindanao set the record proximity to the Equator for its category. Its torrential rains generated an enormous debris flow in the Mayo River watershed that swept away much of the village Andap in the New Bataan municipality, burying areas under rubble as thick as 9 m and killing 566 people. Established in 1968, New Bataan had never experienced super typhoons and debris flows. This unfamiliarity compounded the death and damage. We describe Bopha's history, debris flows and the Mayo River disaster, and then we discuss how population growth contributed to the catastrophe, as well as the possibility that climate change may render other near-Equatorial areas vulnerable to hazards brought on by similar typhoons. Finally, we recommend measures to minimize the loss of life and damage to property from similar future events.

  16. Seroprevalence and correlates of Toxoplasma gondii infection in Yoremes (Mayos) in Mexico: a cross-sectional study

    Science.gov (United States)

    Alvarado-Esquivel, Cosme; Rascón-Careaga, Antonio; Hernández-Tinoco, Jesús; Corella-Madueño, María Alba Guadalupe; Sánchez-Anguiano, Luis Francisco; Aldana-Madrid, María Lourdes; Almada-Balderrama, Gerardo Javier; Nuñez-Aguirre, Alan Daniel; Liesenfeld, Oliver

    2016-01-01

    Objectives We sought to determine the prevalence of anti-Toxoplasma gondii antibodies in Yoremes and to identify associations of T. gondii exposure with sociodemographic, clinical and behavioural characteristics of Yoremes. Design A cross-sectional survey. Setting Yoremes were enrolled in the locality of Tierra Blanca in the municipality of Navojoa in Sonora State, Mexico. Participants We studied 200 Yoremes (Mayos); they are an indigenous ethnic group living in a coastal region in northwestern Mexico. Primary and secondary outcome measures We assessed the prevalence of anti-Toxoplasma IgG and IgM antibodies in participants using enzyme-linked immunoassays. We used a standardised questionnaire to obtain the characteristics of Yoremes. The association of T. gondii exposure and Yoremes’ characteristics was assessed by bivariate and multivariate analyses. Results Of the 200 Yoremes studied (mean age: 31.50±18.43 years), 26 (13.0%) were positive for anti-T. gondii IgG antibodies and 19 (73.1%) of them were also positive for anti-T. gondii IgM antibodies. Seroprevalence of T. gondii infection did not vary with sex, educational level, occupation or socioeconomic status. In contrast, multivariate analysis of sociodemographic and behavioural characteristics showed that T. gondii exposure was associated with increasing age (OR=1.02; 95% CI 1.00 to 1.04; p=0.03) and consumption of squirrel meat (OR=4.99; 95% CI 1.07 to 23.31; p=0.04). Furthermore, seroprevalence of T. gondii infection was significantly higher in Yoremes with a history of lymphadenopathy (p=0.03) and those suffering from frequent abdominal pain (p=0.03). In women, T. gondii exposure was associated with a history of caesarean sections (p=0.03) and miscarriages (p=0.02). Conclusions We demonstrate, for the first time, serological evidence of T. gondii exposure among Yoremes in Mexico. Results suggest that infection with T. gondii might be affecting the health of Yoremes. Results may be useful for an

  17. Síndrome de Hopkins no diagnóstico diferencial das paralisias flácidas na infância: aspectos clínicos e neurofisiológicos. Relato de caso Hopkins' syndrome in the differential diagnosis of flaccid paralysis in children: clinical and neurophysiological features. Case report

    Directory of Open Access Journals (Sweden)

    Daniel B. Nora

    2003-06-01

    Full Text Available INTRODUÇÃO: A síndrome de Hopkins (SH é caracterizada por monoplegia ou diplegia, decorrente de lesão no corno anterior da medula, que se segue a um ataque agudo de asma, ocorre geralmente em crianças e sua etiologia ainda não está definida. Há 34 casos descritos no mundo, sendo este o primeiro relato na América do Sul e durante o primeiro ano de vida. CASO: Criança internada aos 4 meses de idade com quadro de sibilância e insuficiência respiratória. Cerca de 3 dias após melhora do quadro respiratório, observou-se perda de força nos membros inferiores. Teve alta hospitalar com regressão do quadro respiratório mantendo a paraparesia. Reinternada aos 9 meses de idade por novo quadro de broncoespasmo, demonstrando paralisia flácida assimétrica (E>D e atrofia nos membros inferiores. EXAME NEUROLÓGICO: força e reflexos miotáticos normais nos membros superiores, arreflexia miotática nos membros inferiores e sensibilidade preservada. Exames de líquor, ressonância magnética de coluna lombossacra e potencial evocado somatossensitivo dos membros inferiores: normais. BIÓPSIA MUSCULAR: Grupamento de fibras. A eletroneuromiografia demonstrou sinais de lesão do neurônio motor do corno anterior da medula nos metâmeros lombossacros. CONCLUSÃO: A Síndrome de Hopkins, apesar de rara, deve ser lembrada no diagnóstico diferencial de paralisias flácidas, quando houver concomitância com asma.INTRODUCTION: Hopkins syndrome is a motor neuron disease which leads to a flaccid paralysis affecting one or more limbs resembling poliomyelites. It follows an asthmatic attack and the prognosis is poor. All the 34 related cases occured after 13 months of age and there is no report in South America. Our objective is to describe a case of Hopkins Syndrome in Brazil affecting a patient younger than 1 year. CASE: Male 4 months-old infant, started presenting wheezing that turned into respiratory failure which required mecanical ventilation. Three

  18. 77 FR 16668 - Amendment of Class D and E Airspace; Brooksville, FL

    Science.gov (United States)

    2012-03-22

    ... amends Class D and E airspace at Hernando County Airport, Brooksville, FL. The geographic coordinates of... Hernando County Airport, Brooksville, FL, to be in concert with the FAAs aeronautical database, which shows..., and Class E airspace extending upward from 700 feet above the surface, for Hernando County...

  19. L2/FL Teacher Education: Bridging the complexities of Teaching and the Learning of Teaching

    Directory of Open Access Journals (Sweden)

    Karen E. Johnson

    2015-06-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2015v68n1p11 Research on approaches to and the complexities of second and foreign language (L2/FL teaching has dominated the field of L2/FL teacher education for much of its history. (...

  20. 33 CFR 100.736 - Annual Fort Myers Beach air show; Fort Myers Beach, FL.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Annual Fort Myers Beach air show; Fort Myers Beach, FL. 100.736 Section 100.736 Navigation and Navigable Waters COAST GUARD, DEPARTMENT... Fort Myers Beach air show; Fort Myers Beach, FL. (a)(1) Regulated Area. The regulated area is formed...

  1. 76 FR 21266 - Proposed Amendment of Class E Airspace; Cocoa, FL

    Science.gov (United States)

    2011-04-15

    ... Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Cocoa, FL AGENCY... action proposes to amend Class E Airspace at Cocoa, FL, as ] the Merritt Island Non-Directional Beacon... surface to support new standard instrument approach procedures developed at Merritt Island Airport,...

  2. Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator.

    Science.gov (United States)

    Poutiainen, Pekka K; Huhtala, Tuulia; Jääskeläinen, Tiina; Petsalo, Aleksanteri; Küblbeck, Jenni; Kaikkonen, Sanna; Palvimo, Jorma J; Raunio, Hannu; Närvänen, Ale; Peräkylä, Mikael; Juvonen, Risto O; Honkakoski, Paavo; Laatikainen, Reino; Pulkkinen, Juha T

    2014-04-25

    The preclinical profiles of two most potent compounds of our recently published cycloalkane[d]isoxazole pharmacophore-based androgen receptor (AR) modulators, FL442 (4-(3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazol-3-yl)-2-(trifluoromethyl)benzonitrile) and its nitro analog FL425 (3-(4-nitro-3-(trifluoromethyl)phenyl)-3a,4,5,6,7,7a-hexahydrobenzo[d]isoxazole), were explored to evaluate their druggability for the treatment of AR dependent prostate cancer. The studies revealed that both compounds are selective to AR over other closely related steroid hormone receptors and that FL442 exhibits equal inhibition efficiency towards the androgen-responsive LNCaP prostate cancer cell line as the most widely used antiandrogen bicalutamide and the more recently discovered enzalutamide. Notably, FL442 maintains antiandrogenic activity with enzalutamide-activated AR mutant F876L. In contrast to bicalutamide, FL442 does not stimulate the VCaP prostate cancer cells which express elevated levels of the AR. Distribution analyses showed that [(14)CN]FL442 accumulates strongly in the mouse prostate. In spite of its low plasma concentration obtained by intraperitoneal administration, FL442 significantly inhibited LNCaP xenograft tumor growth. These findings provide a preclinical proof for FL442 as a promising AR targeted candidate for a further optimization.

  3. 77 FR 16783 - Proposed Amendment of Class E Airspace; Orlando, FL

    Science.gov (United States)

    2012-03-22

    ... TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 Proposed Amendment of Class E Airspace; Orlando, FL...: This action proposes to amend Class E Airspace at Orlando, FL, as new Standard Instrument Approach Procedures have been developed at Orlando Executive Airport. This action would enhance the safety...

  4. 77 FR 4394 - Release of Airport Property: Orlando Executive Airport, Orlando, FL

    Science.gov (United States)

    2012-01-27

    ... Federal Aviation Administration Release of Airport Property: Orlando Executive Airport, Orlando, FL AGENCY... provides notice of intent to release certain airport properties 12.4 acres at the Orlando Executive Airport, Orlando, FL from the conditions, release certain properties from all terms, conditions, reservations...

  5. Variation der Gehalte an flüchtigen stickstoffhaltigen Basen und "TVB-N" in Rotbarsch

    OpenAIRE

    Oehlenschläger, Jörg

    1989-01-01

    Die Gehalte an den flüchtigen stickstoffhaltigen Aminen, Amoniak, Dimethylamin (DMA), Trimethylamin (TMA) sowie Trimethylaminoxid (TMAO) und der durch Direktdestillation nach milder Alkalisierung mit Magnesiumoxid erhaltende Wert an sogenanntem flüchtigen Basenstickstoff (TVB-N) wurden an fangfrischen Exemplaren von Rotbarsch untersucht.

  6. 33 CFR 100.720 - Annual Suncoast Offshore Grand Prix; Gulf of Mexico, Sarasota, FL.

    Science.gov (United States)

    2010-07-01

    ... Prix; Gulf of Mexico, Sarasota, FL. 100.720 Section 100.720 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.720 Annual Suncoast Offshore Grand Prix; Gulf of Mexico, Sarasota, FL. (a) Regulated area. The regulated area...

  7. 33 CFR 100.719 - Annual Suncoast Offshore Challenge; Gulf of Mexico, Sarasota, FL.

    Science.gov (United States)

    2010-07-01

    ... Challenge; Gulf of Mexico, Sarasota, FL. 100.719 Section 100.719 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.719 Annual Suncoast Offshore Challenge; Gulf of Mexico, Sarasota, FL. (a) Regulated area. The regulated area...

  8. Recursos florísticos de la cuenca baja del río mayo, Sonora

    Directory of Open Access Journals (Sweden)

    Julio César Duarte Ruiz

    2014-06-01

    Full Text Available En México se presentan prácticamente todos los grandes tipos de vegetación que existen en el mundo y su distribución a menudo es compleja. El objetivo del trabajo consistió en realizar un listado de la flora silvestre ribereña del Río Mayo, localizado en el sur del estado de Sonora, para conocer su composición. La recolección de especímenes se realizó mediante la técnica de intercepción o línea de Canfield (1941, en 15 sitios con dos repeticiones sumando 30 transectos. Se encontraron un total de 40 familias, 79 géneros y 99 especies. Las familias mejor representadas fueron: Leguminoseae, Cactaceae, Gramineae, Compositae, Chenopodiaceae, Salicaceae, Solanaceae, Euphorbiaceae, Amaranthaceae y Asteraceae. La dominante fue Leguminoseae con vegetación de bosque espinoso compuesta por Acacia cymbispina, Acacia farnesiana, Parkinsonia aculeata y Prosopis juliflora. Resulta perceptible la pérdida de flora debido al cambio de uso de suelo. Especies representativas de la zona riparia como Populus fremontii y Salix bonplandiana están desapareciendo por alteración del ecosistema. Poblaciones de mangle como Rhizophora mangle y Conocarpus erectus están disminuidas. El área estudiada es rica en especies a pesar de la perturbación. La diversidad varía de acuerdo al gradiente altitudinal y el número de especies guarda relación con los géneros y familias recolectadas. La agricultura, acuicultura, ganadería, la industria pesquera y la urbanización, son los giros que causan mayor afectación en los ecosistemas

  9. Los acontecimientos de mayo del 68 y la lucha antipsiquiátrica

    Directory of Open Access Journals (Sweden)

    Valentín Galván García

    2009-12-01

    Full Text Available Los movimientos de detracción a la psiquiatría clásica no nacieron hasta la década de los años 60. Las reflexiones comunes de sociólogos, filósofos, políticos, psiquiatras y enfermos mentales coincidieron en un severo replanteamiento del saber psiquiátrico y de las prácticas propugnadas. El término propuesto en 1967 por David Cooper fue el estandarte de estos nuevos planteamientos. Con anterioridad al movimiento psiquiátrico, en 1961, se publicaron dos textos fundamentales: Internados de Erving Goffman y la Historia de la locura de Michel Foucault. Ambas obras, hasta entonces, conocidas exclusivamente en el ámbito académico, por lo que sus enfoques y problemáticas tuvieron escasa repercusión hasta los acontecimientos de Mayo del 68, los cuales propiciaron unas condiciones más favorables para su discurso.________________________ABSTRACT:The movements back to the classical psychiatry weren’t born until the 60 ths decade. The common thoughts of sociologists, philosophers, politicians, psychiatrists and mentally sick people joined together a strict reconsideration of the phychiatric knowledge and the proposed training. The word “antipsychiatry” proposed in 1967 by David Cooper was the flagship of these new thoughts. Before the psychiatric movement, in 1961, two main books were published: Asylums by Erving Goffman and History of mandess by Michel Foucault. Both books, until then, were known exclusively in the academic field, for its focus and problems had little repercussion until the May 68 events, which encouraged more favourable conditions for its speech.  

  10. Hill Receives 2003 F.L. Scarf Award

    Science.gov (United States)

    Matthew Hill was awarded the F.L. Scarf Award for his thesis titled Transport phenomena of anomalous cosmic rays during the recovery phase of solar cycle 22. He will be formally presented the award during the AGU 2003 Fall Meeting, which will be held 8-12 December in San Francisco, California, The award is given annually to a recent Ph.D. recipient for outstanding dissertation research that contributes directly to solar-planetary science. Matthew received his B.S. in physics, with high honors, from Rutgers University, New Brunswick, New Jersey, in 1996. He was then granted a Distinguished Research Fellowship for graduate studies in the Department of Physics at the University of Maryland, College Park. Supervised by Douglas C. Hamilton, Matthew earned his M.S. in 1998 and his Ph.D. in physics in 2001. He is currently a research associate at the University of Maryland, where he continues his heliospheric research on the transport of anomalous cosmic rays using particle measurements from the Voyager deep-space probes. Last year, he also joined investigations involving the imaging of magnetospheric neutral atoms with instruments aboard the IMAGE spacecraft.

  11. FL-FN-MOGA Based Traffic Signal Control

    Institute of Scientific and Technical Information of China (English)

    魏武; 张毅

    2003-01-01

    In this paper, a traffic signal control method based on fuzzy logic (FL), fuzzy-neuro (FN) and multi-objective genetic algorithms (MOGA) for an isolated four-approach intersection with through and left-turning movements is presented. This method has an adaptive signal timing ability, and can make adjustments to signal timing in response to observed changes. The "urgency degree" term, which can describe the different user's demand for green time is used in decision-making by which strategy of signal timing can be determined. Using a fuzzy logic controller, we can determine whether to extend or terminate the current signal phase and select the sequences of phases. In this paper, a method based on fuzzy-neuro can be used to predict traffic parameters used in fuzzy logic controller. The feasibility of using a multi-objective genetic algorithm (MOGA) to find a group of optimizing sets of parameters for fuzzy logic controller depending on different objects is also demonstrated. Simulation results show that the proposed methed is effecfive to adjust the signal timing in response to changing traffic conditions on a real-time basis, and the controller can produce lower vehicle delays and percentage of stopped vehicles than a traffic-actuated controller.

  12. Flor de Mayo Eugenia, nueva variedad de frijol para riego y temporal en el centro de México Flor de Mayo Eugenia, new bean cultivar for irrigated and rainfall conditions in Central Mexico

    Directory of Open Access Journals (Sweden)

    Jorge Alberto Acosta Gallegos

    2010-12-01

    Full Text Available Dentro del frijol tipo Flor de Mayo, el subtipo 'media oreja' esta cobrando importancia en el norte-centro de México, éste es de tamaño mediano, forma alargada y color rosa atractivo. Se describe una nueva variedad de este tipo de frijol, Flor de Mayo Eugenia (FME. FME se derivó de una cruza interracial entre Flor de Mayo Anita (FMA (raza Jalisco y Rayado Rojo (raza Nueva Granada. El rendimiento promedio de FME en temporal varia de 0.8 a 2.0 t ha-1 y bajo riego el máximo rendimiento ha sido de 3.8 t ha-1. El peso de 100 semillas promedio de diferentes localidades de FME es significativamente superior al de FMA en condiciones de temporal, 32 vs 26 g 100 semillas, y riego 35 vs 31 g 100 semillas. En cuanto la calidad del grano, el tiempo promedio de cocción de FME en cocedor tipo Mattson es 97 min, mientras que el de FMA es de 109 min; el contenido promedio de proteína del grano de FME es 19% en base a peso seco, similar al de FMA, mientras que el contenido de hierro de FME resultó superior al de FMA con 6.1 vs 5 mg 100 g. FME es tolerante a las razas de roya presentes en el Altiplano de México, a la raza 292 de antracnosis y tolerante a los tizones común y de halo.Within 'Flor de Mayo' bean type, the 'media oreja' subtype is becoming important in North-Central México; this last type has a mid-size elongated seed with showy pink color. A new bean cv. of 'media oreja' subtype is described: Flor de Mayo Eugenia (FME. FME was derived from an interracial cross between Flor de Mayo Anita (FMA (Jalisco breed and Rayado Rojo (Nueva Granada breed. The seed yield of FME under rainfall conditions varied from 0.8 to 2.0 t ha-1 and under irrigation the highest yield recorded was 3.8 t ha-1. The 100-seed weight of FME across different locations was significantly superior to the weight of FMA, 32 vs 26 g per 100 seeds under rainfall conditions and 35 vs 31 g per 100 seeds under irrigation conditions. In regard to seed quality, cooking time average of

  13. Identifying the spatial parameters for differences in gender behaviour in built environments The flâneur and flâneuse of the 21st century

    Directory of Open Access Journals (Sweden)

    Akkelies van Ness

    2013-06-01

    Full Text Available The aim of this research is to show how the spatial features of urban environments affect women and men’s behaviour pattern. The paper’s first part reveals the concept flâneuse in the relationship with the flâneur. Then the spatial parameters of built environments are discussed. As the results from this inquiry show, correlations between the spatial configurative structures and how men and women use urban space were found on the one hand. In spatially integrated streets, an equal number of women and men were found. The more segregated the streets tend to be the more they were dominated by men. On the other hand, as soon as the shops were closed, men dominated the streets. Women are using the street as corridor and not as a destination itself. When women are using the squares in the evening or at night, they are usually accompanied by others. The use of space syntax showed that liveliness could be predicted by the structure of the city. Not only do the crowd provide the flâneuse a valid excuse to wander around the streets, a sense of security, but it’s also a component of flânerie: to see and to be seen. Namely, for the flâneuse liveliness is one of the conditions to stroll around. Hence, knowledge provided from research seems to be essential for designing urban environment attractive for women as well for men. 

  14. La jornada de reconciliación nacional del 5 de mayo de 1958

    Directory of Open Access Journals (Sweden)

    Félix Hernández

    2008-01-01

    Full Text Available En la segunda mitad de la década de los cincuenta la dictadura franquista atravesaba un período de crisis, ante la gravedad de la situación socio-económica que atravesaba el país, es en este contexto en el que el Partido Comunista de España decidió convocar una jornada de movilización contra la dictadura, a la que denominó Jornada de Reconciliación Nacional, para el 5 de mayo de 1958, pese a estar precedida de un período de fuertes protestas sociales los resultados de la misma fueron muy modestos, en este hecho influyeron el propio aislamiento en que se encontraban los comunistas dentro de la oposición antifranquista, como el miedo a la represión, mientras el franquismo continuaría recibiendo el apoyo de las instituciones políticas y grupos sociales sobre las que se asentaba asi como sus apoyos exteriores, lo que le permitiría imponer sus propias soluciones y sobrevivir hasta la muerte del dictador.In the second half of the fifties, the Franco dictatorship was going through a period of crisis given the gravity of the socioeconomic situation that the country was facing. It is in this context that the Spanish Communist Party decided to call mobilization day against dictatorship, which he called National Reconciliation Day, for the 5th of May 1958. Although it was preceded by a period of strong social protest, the results of it were very modest.In this event influenced the isolation itself in which the Communists were inside the anti-Franco opposition, as the fear of repression. While the Franco´s regime would continue receiving the support of political institutions and social groups on which was laid down as well as their external supports, which would enable it to impose its own solutions and survive until the dictator’s death.

  15. Refertilization process in the Patagonian subcontinental lithospheric mantle of Estancia Sol de Mayo (Argentina)

    Science.gov (United States)

    Melchiorre, Massimiliano; Coltorti, Massimo; Gregoire, Michel; Benoit, Mathieu

    2015-05-01

    Anhydrous mantle xenoliths equilibrated at 1003-1040 °C from Estancia Sol de Mayo (ESM, Central Patagonia, Argentina) and entrained in post-plateau alkaline lavas belonging to Meseta Lago Buenos Aires have been investigated aiming at reconstructing the depletion and enrichment processes that affected this portion of the Patagonia lithospheric mantle. Xenoliths are characterized by a coarse-grained protogranular texture and are devoid of evident modal metasomatism. They show two texturally different clinopyroxenes: protogranular (cpx1) and texturally related to spinel (cpx2). Three different types of orthopyroxenes are also recognized: large protogranular crystals with exsolution lamellae (opx1); small clean and undeformed grains without exsolution lamellae (opx2) and small grains arranged in a vein (opx3). Major element composition of clinopyroxenes and orthopyroxenes highlights two different trends characterized by i) a high Al2O3 content at almost constant mg# and ii) a slight increase in Al2O3 content with decreasing mg#. Clinopyroxenes are enriched in LREE and are characterized by prominent to slightly negative Nb, Zr and Ti anomalies. No geochemical differences are observed between cpx1 and cpx2, while a discrimination can be observed between opx1 and opx2 (LREE-depleted; prominent to slightly negative Ti and Zr anomalies) and opx3 (prominent positive Zr anomaly). Partial melting modeling using both major and trace elements indicates a melting degree between ~ 5% and ~ 13% (up to ~ 23% according to major element modeling) for lherzolites and between ~ 20% and ~ 30% for harzburgites (down to ~ 5% according to trace element modeling). La/Yb and Al2O3, as well as Sr and Al2O3 negative correlations in clinopyroxenes point to a refertilization event affecting this lithospheric mantle. The agent was most probably a transitional alkaline/subalkaline melt, as indicated by the presence of orthopyroxene in the vein and the similar geochemical features of ESM

  16. Geografiske forskelle i fløjtrepertoire fra hvidnæsede delfiner?

    DEFF Research Database (Denmark)

    Schmidt, Maria-Louise; Rasmussen, Marianne H.; Miller, Lee

    2009-01-01

    Fløjt fra hvidnæsede delfiner, Lagenorhynchus albirostris optaget i Skjálfandibugten i den nordlige del af Island (2008) blev sammenlignet med fløjt fra Faxaflóibugten fra den sydlige del af Island (1997). Optagelserne fra Skjálfandibugten blev optaget med et specialbygget vertikalt lineært array1...... være at de Islandske hvidnæser bruger samme fløjt repertoire bl.a. fordi det forekommer usandsynligt, at delfiner fra 2008 optagelser er de samme som fra 1997....

  17. Deluges of Grandeur: Water, Territory, and Power on Northwest Mexico’s Río Mayo, 1880-1910

    Directory of Open Access Journals (Sweden)

    Jeffrey M. Banister

    2011-02-01

    Full Text Available Northwest Mexico’s irrigation landscape, known today as El Distrito de Riego 038, or El Valle del Mayo, issues from historical struggles to build an official order out of a diverse world of signs, symbols, processes, places, and peoples. It is the ancestral home of the Yoreme (Mayo, an indigenous group for whom colonisation and agricultural development have meant the loss of autonomy and of the seasonal mobility required to subsist in an arid land. It is also the birthplace of President Álvaro Obregón, a one-time chickpea farmer who transformed late-19th century irrigation praxis into the laws and institutions of 20th century water management. Reshaping territory for the ends of centralising ('federalising' water resources has always proved exceedingly difficult in the Mayo. But this was particularly so in the beginning of the federalisation process, a time of aggressive modernisation under the direction of President Porfirio Díaz (1876-1910. Research on Mexican hydraulic politics and policy, with some important exceptions, has tended to focus on the scale and scope of centralisation. Scholars have paid less attention to the moments and places where water escapes officials’ otherwise ironclad grasp. This paper explores water governance (and state formation more broadly in the late 19th century, on the eve of Mexico’s 1910 Revolution, as an ongoing, ever-inchoate series of territorial claims and projects. Understanding the weaknesses and incompleteness of such projects offers critical insight into post-revolutionary and/or contemporary hydraulic politics.

  18. Los programas de desarrollo Micro-Regional: Caso de la Micro-Región Dos de Mayo

    OpenAIRE

    Rosales Albornoz, Edmundo

    1990-01-01

    Los Programas de Desarrollo Micro-Regional están siendo ejecutados por el actual Gobierno Constitucional con la finalidad de impulsar el desarrollo socio-económico de las zonas deprimidas y coordinar las acciones del sector público. El objetivo central de este trabajo es conocer cómo se están ejecutándose dichos Programas, en especial el Programa de Desarrollo Micro-Regional Dos de Mayo en el Departamento de Huánuco, con la finalidad de formular las recomendaciones del caso.

  19. Recursos naturales y género : el caso de la comunidad Once de Mayo (Campeche, México)

    OpenAIRE

    Flecha Legaz, Carla

    2013-01-01

    Este estudio pretende realizar una aproximación al papel de la cooperación en el empoderamiento femenino sobre los recursos naturales en la comunidad rural mexicana Once de Mayo. Para ello se analizan las experiencias de doce participantes en proyectos destinados a mujeres utilizando como medios la historia de vida, la observación participativa y los talleres. De todo ello se desprende la importancia de que los programas y/o proyectos aborden las necesidades prácticas de las mujeres, vinculad...

  20. The diocese of Astorga, father Flórez and medieval epigraphy

    National Research Council Canada - National Science Library

    Alejandro Celso García Morilla

    2017-01-01

    .... Today we work on Father Flórez through a particular sample, though certainly representative, as it is the diocese of Astorga, corresponding to the XVI volume of his masterpiece “España Sagrada...

  1. EnviroAtlas - Tampa, FL - Meter-Scale Urban Land Cover (MULC) Data (2010)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EnviroAtlas Tampa, FL Meter-Scale Urban Land Cover (MULC) data was generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue...

  2. EnviroAtlas - Tampa, FL - One Meter Resolution Urban Land Cover (2010) Web Service

    Data.gov (United States)

    U.S. Environmental Protection Agency — This EnviroAtlas web service supports research and online mapping activities related to EnviroAtlas (https://www.epa.gov/enviroatlas). The EnviroAtlas Tampa, FL land...

  3. 2008 Northwest Florida Water Management District (NWFWMD) Lidar: Eglin Air Force Base, Walton County, FL

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In the summer of 2008, the Northwest Florida Water Management District collected lidar data over a portion of Walton County, FL (Eglin Air force Base) to support...

  4. Friend or foe? First language (L1 in second/foreign language (L2/FL instruction

    Directory of Open Access Journals (Sweden)

    Channa Liaquat A.

    2017-05-01

    Full Text Available This theoretical review paper investigates the role of first language (L1 in the mainstream scholarship of second/foreign (L2/FL language education in the context of language learning, teaching, and bilingual education. The term ‘mainstream’ refers here to the scholarship that is not informed by sociocultural theory in general and Vygotskian sociocultural theory in particular. The paper later explains a Vygotskian perspective on the use of L1 in L2/FL language education and discusses how the perspective may help content teachers in (a employing L1 in teaching L2/FL content and (b helping L2/FL students to become self-regulative users of the target language.

  5. 78 FR 729 - Ellman Battery Superfund Site; Orlando, Orange County, FL; Notice of Settlement

    Science.gov (United States)

    2013-01-04

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Ellman Battery Superfund Site; Orlando, Orange County, FL; Notice of Settlement AGENCY... concerning a previous Removal Action at the Ellman Battery Superfund Site located in Orlando, Orange...

  6. EnviroAtlas -Tampa, FL- One Meter Resolution Urban Land Cover (2010)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The EnviroAtlas Tampa, FL land cover map was generated from USDA NAIP (National Agricultural Imagery Program) four band (red, green, blue and near infrared) aerial...

  7. 2008 Northwest Florida Water Management District Lidar: Eglin Air Force Base, Walton County, FL

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — In the summer of 2008, the Northwest Florida Water Management District collected lidar data over a portion of Walton County, FL (Eglin Air force Base) to support...

  8. Comentarios a la ponencia de Luis Bernardo Flórez

    Directory of Open Access Journals (Sweden)

    Misas Arango Gabriel

    2001-08-01

    Full Text Available Crítica e interpretación a la ponencia expuesta por Luis Bernardo Flórez en el IV Congreso de Economistas de la Universidad Nacional de Colombia: ponencias y comentarios.

  9. Regional Sediment Management (RSM) Assessment of Longboat Pass, Manatee County, FL

    Science.gov (United States)

    2016-06-01

    Pass , Manatee County, FL by Kelly R. Legault PURPOSE: This Coastal and Hydraulics Engineering Technical Note (CHETN) describes the history of...ebb shoal morphology at Longboat Pass , Manatee County, FL, based on a review of the history and the recent inlet management studies for proposed...navigational dredging of the Pass . The study area is located on the southwest Gulf of Mexico coast of Florida (Figure 1). The goals of the study were to

  10. Schools of language teaching methodology and teacher's roles in SL/FL classroom

    Institute of Scientific and Technical Information of China (English)

    李垂佳

    2009-01-01

    This paper presents the teaching methods employed by different schools of language teaching respectively and the historical trend of the roles of language teacher in SL/FL classroom. The purpose of this paper is to survey the dif-ferent roles language teachers play with the advent of a new teaching method so as to supply a better interpretation of the language teachers' behaviors in the SL/FL classroom and to indicate the likely developments in language pedagogy in the future.

  11. Actitud del gobierno ante el 1º de mayo, desde 1890 hasta la Segunda República

    Directory of Open Access Journals (Sweden)

    Lucía Rivas Lara

    1988-01-01

    Full Text Available El 1° de Mayo, cuyo origen estuvo en la aspiración obrera a la jornada de ocho horas, se celebró por primera vez en Estados Unidos en 1886, después de muchos años de lucha de los trabajadores en los diversos países por el acortamiento de las jornadas, dado que hasta entonces habían sido de 12 a 16 horas según los lugares. Pero este 1° de mayo de 1886 tuvo un nacimiento espontáneo entre los trabajadores anarquistas norteamericanos, merced a la decisión de un congreso de la Federación Americana del Trabajo (AFL, sin perspectiva de continuidad ni trascendencia más allá de sus fronteras. No obstante, en el marco de su país tuvo un notable éxito consiguiendo con él muchos trabajadores la jornada de ocho horas, y sirviendo de precedente.

  12. E2fl1 is a meiosis-specific transcription factor in the protist Tetrahymena thermophila.

    Science.gov (United States)

    Zhang, Jing; Tian, Miao; Yan, Guan-Xiong; Shodhan, Anura; Miao, Wei

    2017-01-02

    Members of the E2F family of transcription factors have been reported to regulate the expression of genes involved in cell cycle control, DNA replication, and DNA repair in multicellular eukaryotes. Here, E2FL1, a meiosis-specific E2F transcription factor gene, was identified in the model ciliate Tetrahymena thermophila. Loss of this gene resulted in meiotic arrest prior to anaphase I. The cytological experiments revealed that the meiotic homologous pairing was not affected in the absence of E2FL1, but the paired homologous chromosomes did not separate and assumed a peculiar tandem arrangement. This is the first time that an E2F family member has been shown to regulate meiotic events. Moreover, BrdU incorporation showed that DSB processing during meiosis was abnormal upon the deletion of E2FL1. Transcriptome sequencing analysis revealed that E2FL1 knockout decreased the expression of genes involved in DNA replication and DNA repair in T. thermophila, suggesting that the function of E2F is highly conserved in eukaryotes. In addition, E2FL1 deletion inhibited the expression of related homologous chromosome segregation genes in T. thermophila. The result may explain the meiotic arrest phenotype at anaphase I. Finally, by searching for E2F DNA-binding motifs in the entire T. thermophila genome, we identified 714 genes containing at least one E2F DNA-binding motif; of these, 235 downregulated represent putative E2FL1 target genes.

  13. CONTRA LA DESPOLITIZACIÓN DE LA MEMORIA. ENTREVISTA CON CARLOS ANTONIO AGUIRRE ROJAS, A PROPÓSITO DE LOS 40 AÑOS DE MAYO DEL 68

    Directory of Open Access Journals (Sweden)

    John Jaime Correa Ramírez

    2008-01-01

    Full Text Available Con motivo de la celebración de los 40 años de mayo del 68, se realizaron algunas conferencias con invitados internacionales en la Universidad Tecnológica de Pereira. Se aprovecho la visita del historiador mexicano Carlos Antonio Aguirre Rojas, para realizar una entrevista en la que ampliara sus conceptos respecto al significado histórico de Mayo del 68, su pervivencia en los imaginarios de muchos movimientos estudiantiles del presente, y al mismo tiempo, sus diferentes percepciones respecto a la historiografía tradicional y al movimiento zapatista.

  14. Salinity monitoring using remote sensing in the 038 Rio Mayo Irrigation District. Sonora, Mexico, by remote sensing; Monitoreo de la salinidad en el Distrito de Riego 038 Rio Mayo Sonora, Mexico, mediante sensores remotos

    Energy Technology Data Exchange (ETDEWEB)

    Pulido Madrigal, L.; Gonzalez Meraz, J.

    2009-07-01

    a soil salinity survey was carried out in the Rio Mayo irrigation district (ID) in 1996, using satellite imagery along with and EM-38 electromagnetic (EM) device. Data from Landsat TM imagery were calibrated with field data, according to the Plant Indicator methodology. This methodology yielded a partial salinity map of the ID, but including only those areas where indicator crops were cultivated. The remaining non-mapped areas were surveyed with an EM-38 electromagnetic device, generating a second partial salinity map. Both partial maps were integrated to get a complete soil salinity map of the ID. In 2001, another soil salinity survey was carried out using solely the EM device. The results of both methodologies were analyzed, resulting in less affected areas in 2001 compared too those obtained in 1996. (Author) 4 refs.

  15. Making Canada a destination for medical tourists: why Canadian provinces should not try to become "Mayo Clinics of the North".

    Science.gov (United States)

    Turner, Leigh

    2012-05-01

    When Canadian researchers examine the subject of medical tourism, they typically focus on ethical, social, public health and health policy issues related to Canadians seeking health services in other countries. They emphasize study of Canada as a departure point for medical tourists rather than as a potential destination for international patients. Several influential voices have recently argued that provincial healthcare systems in Canada should market health services to international patients. Proponents of marketing Canada as a destination for medical tourists argue that attracting international patients will generate revenue for provincial healthcare systems. Responding to such proposals, I argue that there are at least seven reasons why provincial health systems in Canada should not dedicate institutional, financial and health human resources to promoting themselves as destinations for medical tourists.

  16. Quality initiatives: improving patient flow for a bone densitometry practice: results from a Mayo Clinic radiology quality initiative.

    Science.gov (United States)

    Aakre, Kenneth T; Valley, Timothy B; O'Connor, Michael K

    2010-03-01

    Lean Six Sigma process improvement methodologies have been used in manufacturing for some time. However, Lean Six Sigma process improvement methodologies also are applicable to radiology as a way to identify opportunities for improvement in patient care delivery settings. A multidisciplinary team of physicians and staff conducted a 100-day quality improvement project with the guidance of a quality advisor. By using the framework of DMAIC (define, measure, analyze, improve, and control), time studies were performed for all aspects of patient and technologist involvement. From these studies, value stream maps for the current state and for the future were developed, and tests of change were implemented. Comprehensive value stream maps showed that before implementation of process changes, an average time of 20.95 minutes was required for completion of a bone densitometry study. Two process changes (ie, tests of change) were undertaken. First, the location for completion of a patient assessment form was moved from inside the imaging room to the waiting area, enabling patients to complete the form while waiting for the technologist. Second, the patient was instructed to sit in a waiting area immediately outside the imaging rooms, rather than in the main reception area, which is far removed from the imaging area. Realignment of these process steps, with reduced technologist travel distances, resulted in a 3-minute average decrease in the patient cycle time. This represented a 15% reduction in the initial patient cycle time with no change in staff or costs. Radiology process improvement projects can yield positive results despite small incremental changes.

  17. Validation of the revised International Prognostic Score of Thrombosis for Essential Thrombocythemia (IPSET-thrombosis) in 585 Mayo Clinic patients.

    Science.gov (United States)

    Haider, Mahnur; Gangat, Naseema; Lasho, Terra; Abou Hussein, Ahmed K; Elala, Yoseph C; Hanson, Curtis; Tefferi, Ayalew

    2016-06-01

    The primary objective of treatment in essential thrombocythemia (ET) is to prevent thromboembolic complications. In this regard, advanced age and thrombosis history have long distinguished "low" from "high" risk patients. More recently, JAK2V617F and cardiovascular (CV) risk factors were identified as additional modifiers, leading to the development of a 3-tiered International Prognostic Score of Thrombosis for ET (IPSET-thrombosis): "low," "intermediate," and "high". The international data set used to develop IPSET-thrombosis was recently re-analyzed in order to quantify the additional pro-thrombotic effect of JAK2V617F and CV risk factors in specific risk subcategories. The revised IPSET-thrombosis identified four risk categories based on three adverse variables (thrombosis history, age >60 years and JAK2V617F): very low (no adverse features), low (presence of JAK2V617F), intermediate (age >60 years) and high (presence of thrombosis history or presence of both advanced age and JAK2V617F). In this study of 585 patients with ET (median age 68 years; 61% female), we validated the revised IPSET-thrombosis by confirming significant differences in thrombosis risk between "very low" and "low" (HR 2.4, 95% CI 1.1 - 5.3) and between "intermediate" and "high" (HR 2.3, 95% CI 1.1 - 5.2) risk patients. Furthermore, in multivariable analysis, only JAK2V617F (HR=1.8, CI= 1.07 - 2.94) and history of thrombosis (HR=2.1, CI= 1.20 - 3.58) were independently predictive of future thrombotic events. The revised IPSET-thrombosis needs confirmation in prospective studies, especially in terms of risk-adapted therapy that includes the need for aspirin therapy in very low risk, twice-daily aspirin therapy for low risk and cytoreductive therapy for low or intermediate risk patients.

  18. Sex and ethnic differences in 47 candidate proteomic markers of cardiovascular disease: the Mayo Clinic proteomic markers of arteriosclerosis study.

    Directory of Open Access Journals (Sweden)

    Charles X Kim

    Full Text Available BACKGROUND: Cardiovascular disease (CVD susceptibility differs between men and women and varies with ethnicity. This variability is not entirely explained by conventional CVD risk factors. We examined differences in circulating levels of 47 novel protein markers of CVD in 2561 men and women of African-American (AA and non-Hispanic White (NHW ethnicity, enrolled at geographically distinct sites. METHODOLOGY/PRINCIPAL FINDINGS: Participants (1,324 AAs, mean age 63.5 y, 71% women; 1,237 NHWs, mean age 58.9 y, 57% women belonged to sibships ascertained on the basis of hypertension. Solid-phase immunoassays and immunoturbidometric, clot-based, chromogenic, and electrophoretic assays were used to measure the 47 protein markers in plasma or serum. Marker levels were log transformed and outliers were adjusted to within 4 SD. To identify markers independently associated with sex or ethnicity, we employed multivariable regression analyses that adjusted for conventional risk factors, prior history of CVD, medication use and lifestyle factors (physical activity, alcohol consumption and education. Generalized estimating equations were used to correct for intrafamilial correlations. After adjustment for the above covariates, female sex was associated with higher levels of 29 markers and lower levels of 6 markers. Female sex was independently associated with higher levels of several inflammatory markers as well as lipoproteins, adipokines, natriuretic peptides, vasoconstrictor peptides and markers of calcification and thrombosis. AA ethnicity was associated with higher levels of 19 markers and lower levels of 6 markers, including higher levels of several inflammatory makers, higher leptin and lower adiponectin levels, lower levels of vasodilator-natriuretic peptides, higher levels of vasoconstrictor-antidiuretic peptides and markers of calcification and thrombosis. CONCLUSIONS/SIGNIFICANCE: Plasma levels of several novel protein markers of CVD differ significantly in the context of sex and ethnicity. These results have implications for individualized CVD risk assessment.

  19. Conhecimento de alunos do Curso de Odontologia sobre o uso racional do flúor

    Directory of Open Access Journals (Sweden)

    Solane Domingues Leal

    Full Text Available INTRODUÇÃO: O uso do flúor sob a forma de fluoreto é o principal fator de proteção no controle da cárie dentária, em todo o mundo. O flúor pode ser oferecido à população de diversas formas, sendo as mais utilizadas a fluoretação da água de abastecimento e os dentifrícios fluoretados. Entretanto, a exposição ao flúor também pode ocorrer por meio das soluções para bochechos; de géis e materiais de uso odontológico, e da dieta, por meio de alimentos e bebidas industrializados. OBJETIVO: Este estudo objetivou verificar o conhecimento dos alunos de diferentes semestres do curso de Odontologia da Universidade Estadual do Sudoeste da Bahia sobre o uso racional do flúor. MATERIAL E MÉTODO: Realizou-se um estudo transversal, sendo a amostra composta por acadêmicos de diferentes semestres do curso de Odontologia, que responderam a um questionário para verificar seus conhecimentos em relação ao flúor. RESULTADO: Dos acadêmicos entrevistados, 58,16% consideraram o alto risco à cárie e a hipersensibilidade dentinária como os principais fatores para a indicação do flúor. Para 64,29%, o gel foi o produto fluoretado mais indicado na sua prática diária, e 67,35% indicaram o dentifrício fluoretado para crianças com idade superior a seis anos. Parte significativa da amostra afirmou saber sobre a presença de flúor em alimentos industrializados (91,84% e reconhecer que o flúor é tóxico (93,88%. CONCLUSÃO: Apesar das informações sobre flúor adquiridas no decorrer do curso, expressiva parte dos alunos ainda não possui domínio sobre o assunto e mostrou-se insegura para poder recomendá-lo na sua prática clínica diária.

  20. A brief report on WAIS-R normative data collection in Mayo's Older African Americans Normative Studies.

    Science.gov (United States)

    Lucas, John A; Ivnik, Robert J; Smith, Glenn E; Ferman, Tanis J; Willis, Floyd B; Petersen, Ronald C; Graff-Radford, Neill R

    2005-06-01

    Historically, neuropsychological measures such as the Wechsler Adult Intelligence Scale-Revised (WAIS-R) have yielded unacceptably high rates of misdiagnosis of impairment among cognitively normal African Americans, primarily due to poor test specificity and inadequate representation of ethnic minorities in the normative sample. In this report, we briefly review these issues and describe efforts by investigators in Mayo's Older African Americans Normative Studies (MOAANS) to develop more appropriate norms for African American elders on the WAIS-R. During MOAANS data collection, the third edition of the WAIS (WAIS-III) was introduced with updated representation of ethnic minorities in the normative database. More recently, specific demographic corrections for African Americans have been derived for WAIS-III subtest scores and indices. As such, WAIS-R normative estimates are not presented here. Interested readers who wish to obtain a full set of MOAANS WAIS-R norms, however, are invited to contact the authors for these data.

  1. Gastrointestinal helminths of Gentoo penguins (Pygoscelis papua) from Stranger Point, 25 de Mayo/King George Island, Antarctica.

    Science.gov (United States)

    Diaz, Julia Inés; Fusaro, Bruno; Longarzo, Lucrecia; Coria, Néstor Rubén; Vidal, Virginia; Jerez, Silvia; Ortiz, Juana; Barbosa, Andrés

    2013-05-01

    The aim of this work is to contribute to the knowledge of gastrointestinal parasites of the Gentoo penguin (Pygoscelis papua) from 25 de Mayo/King George Island (South Shetlands, Antarctica). Gastrointestinal tracts of 37 fresh dead individuals (21 chicks, 10 juveniles, and 6 adults) were collected from December 2006 to February 2012 and examined for macroparasites. Four adult parasite species were found: one Cestoda species (Parorchites zederi), two Nematoda species (Stegophorus macronectes and Tetrameres wetzeli), and one Acanthocephalan (Corynosoma shackletoni). Two species of immature acanthocephalans, Corynosoma hamanni and Corynosoma bullosum, were found in a single host. This is the first record of Tetrameres wetzeli in Gentoo penguins. The low parasite richness observed could be related to the stenophagic and pelagic diet of this host species which feeds almost exclusively on krill.

  2. A look into the 21st century as viewed by a Mayo Health System patient care executive.

    Science.gov (United States)

    McBeth, A

    2000-01-01

    The 21st century needs to be dedicated to the broader vision of building healthy communities. The challenge for us as leaders in the communities in which we live and work will be to develop a nondisparate shared vision of health that serves all populations from birth to death. Disparity benchmarks and indicators will be key in order to achieve the U.S. Surgeon General's commitment to eliminate the disparities in health in this new century. Florence Nightingale's 19th century vision of creating an environment of healing--together with the Mayo brothers' primary value that the needs of the patient come first, which were set forth during the same time period--needs to guide us as we embark upon our 21st century journey.

  3. The US Supreme Court in Mayo v. Prometheus - Taking the fire from or to biotechnology and personalized medicine?

    DEFF Research Database (Denmark)

    Minssen, Timo; Nilsson, David

    2012-01-01

    On 20 March 2012, the US Supreme Court handed down its much awaited patent eligibility- ruling in the dispute between Prometheus Laboratories Inc (“Prometheus”), acting as plaintiffs, and Mayo Medical Laboratories (“Mayo”), as alleged infringers of Prometheus’ licensed patents. This case review w...... including some comparative European views (4). The paper concludes with general remarks (5)....

  4. SIGNIFICANCE OF RHYTHMIC CULTURAL INPUT IN DEALING WITH FOSSILIZATION IN L2/FL TEACHING

    Institute of Scientific and Technical Information of China (English)

    LiYan

    2004-01-01

    Based on research carried out on four pilot classes,this paper makes surveys how intercultural factors can lead to fossilization in second language learning and foreign language (L2/FL) learning process, so as to highlight the magnificent value of deep-structure cultural transfer in L2/FL teaching and learning procedure. Furthermore. the paper goes deeper into the significance of rhythmic and contrastive cultural input in L2/FL class via analysis on results of sampled items. The paper reaches a conclusion that contrastive deep-structure cultural transfer is basically “I+I” approach in cultural instruction in nature, but the point is how it goes is in accordance with human knowledge/skill acquisition principle.

  5. Cross-cultural perspective of FL teaching and learning in the Polish context

    Directory of Open Access Journals (Sweden)

    Paweł Sobkowiak

    2012-10-01

    Full Text Available This study examines whether learners’ capacity to use a foreign language (FL successfully in the global world is developed in the FL classroom in Polish high schools. The article reports results of the quantitative research which aimed at assessing whether and to what extent homogeneous FL classes in Poland are conducive to developing learners’ intercultural (IC sensitivity and competence. The results obtained from the two study samples, namely learners and teachers, are contradictory: In the students’ opinion, IC teaching/learning plays a marginal role, whereas the teacher respondents claim they practice IC teaching moderately. Thus, to be able to get a broader picture of IC teaching/learning in Poland the current research should be complemented by a separate qualitative study, that is, lesson observations and interviews with teachers and students. Only then could more valid conclusions be drawn.

  6. Flüchtlingskrise im Nahen Osten : Syrien und Jordanien überfordert

    OpenAIRE

    Zorob, Anja

    2007-01-01

    "Täglich berichten deutsche und internationale Medien über Anschläge und Tote im Irak. Relativ verborgen vor dem Auge der Öffentlichkeit blieb bislang jedoch das, was durch Besetzung, Gewalt und Zerstörung ausgelöst wurde - die seit 1948 größte Flüchtlingskrise im Nahen Osten. Laut Angaben des UN-Flüchtlingswerks (United Nations High Commissioner for Refugees - UNHCR) haben seit 2003, als US-amerikanische und britische Truppen in das Land einmarschierten, um das Regime von Saddam Hussein zu s...

  7. In the city of Sylvia or the Flâneur´s city

    Directory of Open Access Journals (Sweden)

    Luz Marina ORTIZ AVILÉS

    2015-12-01

    Full Text Available The flâneur, a figure mainly related to artistic disciplines such as literature, painting and photography, has been scarcely approached in cinema. Although it is possible to find some films where this figure has been slightly insinuated, up to now we had not been able to find a cinematographic work that we can take as an obvious reference. We think José Luis Guerin’s En la ciudad de Sylvia manages to fill that referential gap. Therefore our analysis and reflections try to shed light on the relations between the main character of the film and the flâneur.

  8. Rendimiento y reacción a enfermedades en frijol tipo Flor de Mayo en riego y temporal Seed yield and disease reaction in Flor de Mayo bean type grown under irrigation and rainfed conditions

    Directory of Open Access Journals (Sweden)

    Jorge Alberto Acosta Gallegos

    Full Text Available El frijol tipo Flor de Mayo es de alta demanda entre los consumidores del centro de México, su producción se realiza en las regiones de la Mesa Central, El Bajío y Semiárida. El objetivo fue determinar el rendimiento, peso de la semilla y reacción a enfermedades de un grupo de 14 líneas y dos testigos a través de 14 ambientes, 10 de temporal y cuatro de riego. Los ensayos se condujeron durante los ciclos primavera-verano 2008 y otoño-invierno 2008-2009. Se realizaron análisis de conjunto y por ensayos de temporal y de riego en forma independiente. Diferentes enfermedades atacaron al cultivo a través de los sitios de prueba; bajo temporal, las de mayor distribución fueron la bacteriosis común (Xanthomonas campestris pv phaseoli y la mancha angular (Phaeoisariopsis griseola; mientras que la antracnosis (Colletotrichum lindemuthianum y el mildiú velloso (Phythohpthora phaseoli mostraron un fuerte ataque en Calera, Zacatecas y Celaya, Guanajuato, respectivamente. El ambiente de mayor rendimiento promedio fue Celaya bajo riego (4.15 t ha-1 y el menor se obtuvo en Texcoco bajo temporal (0.90 t ha-1. El análisis conjunto detecto diferencias significativas (pThe 'Flor de Mayo' bean type is highly demanded by consumers in Central Mexico, its production takes place at the semiarid, El Bajio and the central plateau regions. The aim was to test a set of 14 bred lines plus two checks across 10 rainfed locations and four irrigated sites on the basis of seed yield, 100-seeds weight and disease reaction. Trials were conducted in the spring-summer season 2008 and fall-winter season 2008-2009. Data analyses were conducted including all test sites, and independently rainfed and irrigated sites. Different diseases attacked the crop across test sites; those widely distributed were common bacterial blight (Xanthomonas campestris pv phaseoli and angular leaf spot (Phaeoisariopsis griseola; whereas anthracnose (Colletotrichum lindemuthianum and downy

  9. A designated centre for people with disabilities operated by Western Care Association, Mayo

    LENUS (Irish Health Repository)

    Fitzgerald, C

    2016-04-27

    In an era when clinical microbiology laboratories are under increasing financial pressure, there is a need for inexpensive, yet effective, rapid microbiology tests. The aim of this study was to evaluate a novel modification of standard methodology for the identification and antimicrobial susceptibility testing (AST) of pathogens in positive blood cultures, reducing the turnaround time of laboratory results by 24 h.

  10. Insight, Automatization and Creativity as a Strategy in F-L Learning

    Science.gov (United States)

    Keuleers, Alfons

    1974-01-01

    Part I reviews foreign language teaching methodologies and suggests extracting the most effective aspects of each to be synthesized into the Cognitive-Active-Situational (CAS) Method. Part II presents results of an experiment done to find the best way of achieving optimum balance between thinking and doing within the CAS Method. See FL 507 969 for…

  11. 77 FR 63722 - Special Local Regulations; Palm Beach World Championship, Atlantic Ocean; Jupiter, FL

    Science.gov (United States)

    2012-10-17

    ..., Atlantic Ocean; Jupiter, FL AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast... Indiantown Road and Donald Ross Road, just offshore of Jupiter, Florida during the Palm Beach World... will be held on the waters of the Atlantic Ocean, just offshore of Jupiter, Florida. The high...

  12. Phylogenetic inferences in Avena based on analysis of FL intron2 sequences.

    Science.gov (United States)

    Peng, Yuan-Ying; Wei, Yu-Ming; Baum, Bernard R; Yan, Ze-Hong; Lan, Xiu-Jin; Dai, Shou-Fen; Zheng, You-Liang

    2010-09-01

    The development and application of molecular methods in oats has been relatively slow compared with other crops. Results from the previous analyses have left many questions concerning species evolutionary relationships unanswered, especially regarding the origins of the B and D genomes, which are only known to be present in polyploid oat species. To investigate the species and genome relationships in genus Avena, among 13 diploid (A and C genomes), we used the second intron of the nuclear gene FLORICAULA/LEAFY (FL int2) in seven tetraploid (AB and AC genomes), and five hexaploid (ACD genome) species. The Avena FL int2 is rather long, and high levels of variation in length and sequence composition were found. Evidence for more than one copy of the FL int2 sequence was obtained for both the A and C genome groups, and the degree of divergence of the A genome copies was greater than that observed within the C genome sequences. Phylogenetic analysis of the FL int2 sequences resulted in topologies that contained four major groups; these groups reemphasize the major genomic divergence between the A and C genomes, and the close relationship among the A, B, and D genomes. However, the D genome in hexaploids more likely originated from a C genome diploid rather than the generally believed A genome, and the C genome diploid A. clauda may have played an important role in the origination of both the C and D genome in polyploids.

  13. 75 FR 11936 - Radisys Corporation, Boca Raton, FL; Notice of Termination of Investigation

    Science.gov (United States)

    2010-03-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Radisys Corporation, Boca Raton, FL; Notice of Termination of... Corporation, Boca Raton, Florida. The petitioning worker group is covered by an earlier petition (TA-...

  14. 76 FR 78151 - Special Local Regulations; Boca Raton Holiday Boat Parade, Intracoastal Waterway, Boca Raton, FL

    Science.gov (United States)

    2011-12-16

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations; Boca Raton Holiday Boat Parade, Intracoastal Waterway, Boca Raton, FL AGENCY: Coast Guard, DHS. ACTION: Temporary final rule... Waterway in Boca Raton, Florida during the Boca Raton Holiday Boat Parade on Saturday, December 17,...

  15. 77 FR 75550 - Special Local Regulations; 2013 Orange Bowl Paddle Championship, Biscayne Bay, Miami, FL

    Science.gov (United States)

    2012-12-21

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations; 2013 Orange Bowl Paddle... in Miami, FL during the 2013 Orange Bowl Paddle Championship. The event will take place on January 13... Paddle Championship. C. Discussion of the Final Rule On January 13, 2013, the Orange Bowl Committee...

  16. 77 FR 26035 - St. Vincent National Wildlife Refuge, FL; Draft Comprehensive Conservation Plan and Environmental...

    Science.gov (United States)

    2012-05-02

    ...; FXRS12650400000S3-123-FF04R02000] St. Vincent National Wildlife Refuge, FL; Draft Comprehensive Conservation Plan... principles of fish and wildlife management, conservation, legal mandates, and our policies. In addition to... wildlife biologist student through the Student Career Experience Program, continue the Youth...

  17. 77 FR 27792 - Chassahowitzka National Wildlife Refuge, FL; Draft Comprehensive Conservation Plan and...

    Science.gov (United States)

    2012-05-11

    ... and the cause of waterfowl population declines on the refuge since the 1970s; (3) evaluating the... Fish and Wildlife Service Chassahowitzka National Wildlife Refuge, FL; Draft Comprehensive Conservation... Chassahowitzka National Wildlife Refuge (NWR) in Citrus and Hernando Counties, Florida, for public review and...

  18. 77 FR 50062 - Safety Zone; Embry-Riddle Wings and Waves, Atlantic Ocean; Daytona Beach, FL

    Science.gov (United States)

    2012-08-20

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Embry-Riddle Wings and Waves, Atlantic... Daytona Beach, Florida during the Embry-Riddle Wings and Waves air show. The event is scheduled to take...: Sec. 165.T07-0653 Safety Zone; Embry Riddle Wings and Waves, Atlantic Ocean, Daytona Beach, FL. (a...

  19. 78 FR 67209 - Florida Disaster #FL-00094 Declaration of Economic Injury

    Science.gov (United States)

    2013-11-08

    ... From the Federal Register Online via the Government Publishing Office SMALL BUSINESS ADMINISTRATION Florida Disaster FL-00094 Declaration of Economic Injury AGENCY: U.S. Small Business...: 07/31/2014. ADDRESSES: Submit completed loan applications to: U.S. Small Business...

  20. 75 FR 79293 - Amendment and Revocation of Class E Airspace; Vero Beach, FL

    Science.gov (United States)

    2010-12-20

    ... a notice of proposed rulemaking to amend and remove Class E airspace at Vero Beach, FL (75 FR 65581... Federal Aviation Administration 14 CFR Part 71 Amendment and Revocation of Class E Airspace; Vero Beach... removes Class E airspace designated as an extension to Class D surface area at Vero Beach...

  1. Liberación de iones flúor en materiales dentales

    OpenAIRE

    Salmeron-Váldes, Elías Nahum

    2016-01-01

    Tesis de Doctorado que contiene el análisis y la cuantificación del flúor liberado en algunos materiales dentales como lo son Cementos de Ionómero de vidrio, Selladores de fosas y fisuras, pastas dentales y barnices.

  2. 76 FR 69222 - Radio Broadcasting Services; Evergreen, AL, and Shalimar, FL

    Science.gov (United States)

    2011-11-08

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Evergreen, AL, and Shalimar, FL AGENCY: Federal Communications Commission. ACTION: Dismissal. ] SUMMARY: The Audio Division, at the request of Qantum of...

  3. 78 FR 13339 - Florida Petroleum Reprocessors Site; Davie, Broward County, FL; Notice of Settlement

    Science.gov (United States)

    2013-02-27

    ... AGENCY Florida Petroleum Reprocessors Site; Davie, Broward County, FL; Notice of Settlement AGENCY... Agency has entered into a settlement with 2238 NW. 86th Street Inc. concerning the Florida Petroleum... Ms. Paula V. Painter. Submit your comments by Site name Florida Petroleum Reprocesssors Site by one...

  4. 75 FR 53694 - Florida Petroleum Reprocessors Superfund Site; Davie, Broward County, FL; Notice of Settlement

    Science.gov (United States)

    2010-09-01

    ...] Florida Petroleum Reprocessors Superfund Site; Davie, Broward County, FL; Notice of Settlement AGENCY... Florida Petroleum Reprocessors Superfund Site located in Davie, Broward County, Florida for publication..., identified by Docket ID No. EPA-RO4- SFUND-2010-0729 or Site name Florida Petroleum Reprocessors Superfund...

  5. 77 FR 16548 - Florida Petroleum Reprocessors Superfund Site; Davie, Broward County, FL; Notice of Settlements

    Science.gov (United States)

    2012-03-21

    ...] Florida Petroleum Reprocessors Superfund Site; Davie, Broward County, FL; Notice of Settlements AGENCY... entered into four (4) settlements for past response costs concerning the Florida Petroleum Reprocessors... settlement are available from Ms. Paula V. Painter. Submit your comments by Site name Florida Petroleum...

  6. Moving beyond flat earth: dense 3D scene reconstruction from a single FL-LWIR camera

    Science.gov (United States)

    Stone, K.; Keller, J. M.; Anderson, D. T.

    2013-06-01

    In previous work an automatic detection system for locating buried explosive hazards in forward-looking longwave infrared (FL-LWIR) and forward-looking ground penetrating radar (FL-GPR) data was presented. This system consists of an ensemble of trainable size-contrast filters prescreener coupled with a secondary classification step which extracts cell-structured image space features, such as local binary patterns (LBP), histogram of oriented gradients (HOG), and edge histogram descriptors (EHD), from multiple looks and classifies the resulting feature vectors using a support vector machine. Previously, this system performed image space to UTM coordinate mapping under a flat earth assumption. This limited its applicability to flat terrain and short standoff distances. This paper demonstrates a technique for dense 3D scene reconstruction from a single vehicle mounted FL-LWIR camera. This technique utilizes multiple views and standard stereo vision algorithms such as polar rectification and optimal correction. Results for the detection algorithm using this 3D scene reconstruction approach on data from recent collections at an arid US Army test site are presented. These results are compared to those obtained under the flat earth assumption, with special focus on rougher terrain and longer standoff distance than in previous experiments. The most recent collection also allowed comparison between uncooled and cooled FL-LWIR cameras for buried explosive hazard detection.

  7. 78 FR 79061 - Noise Exposure Map Notice; Key West International Airport, Key West, FL

    Science.gov (United States)

    2013-12-27

    ... Federal Aviation Administration Noise Exposure Map Notice; Key West International Airport, Key West, FL... Administration (FAA) announces its determination that the Noise Exposure Maps submitted by Monroe County for the Key West International Airport under the provisions of the Aviation Safety and Noise Abatement Act...

  8. 75 FR 76067 - Noise Exposure Map Notice, Naples Municipal Airport, Naples, FL

    Science.gov (United States)

    2010-12-07

    ... Federal Aviation Administration Noise Exposure Map Notice, Naples Municipal Airport, Naples, FL AGENCY...) announces its determination that the Noise Exposure Maps submitted by Naples Airport Authority for Naples Municipal Airport under the provisions of 49 U.S.C. 47501 et. seq (Aviation Safety and Noise Abatement...

  9. 76 FR 68314 - Special Local Regulations; Key West World Championship, Atlantic Ocean; Key West, FL

    Science.gov (United States)

    2011-11-04

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations; Key West World Championship, Atlantic Ocean; Key West, FL AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast... Key West, Florida during the Key West World Championship, a series of high-speed boat races. The...

  10. 33 CFR 100.718 - Annual Suncoast Kilo Run; Sarasota Bay, Sarasota, FL.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Annual Suncoast Kilo Run; Sarasota Bay, Sarasota, FL. 100.718 Section 100.718 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.718...

  11. Comentarios a la ponencia de Luis Bernardo Flórez

    Directory of Open Access Journals (Sweden)

    González Muñoz César

    2001-08-01

    Full Text Available Crítica e interpretación a la ponencia expuesta por Luis Bernardo Flórez en el IV Congreso de Economistas de la Universidad Nacional de Colombia: ponencias y comentarios.

     

  12. Amphibian antimicrobial peptide fallaxin analogue FL9 affects virulence gene expression and DNA replication in Staphylococcus aureus

    DEFF Research Database (Denmark)

    Gottschalk, Sanne; Gottlieb, Caroline Trebbien; Vestergaard, Martin

    2015-01-01

    the MIC, FL9 bound DNA, inhibited DNA synthesis and induced the SOS DNA damage response, whereas at concentrations above the MIC the interaction between S. aureus and FL9 led to membrane disruption. The antibacterial activity of the peptide was maintained over a wide range of NaCl and MgCl2 concentrations...

  13. 76 FR 78529 - Establishment of Class D and E Airspace and Amendment of Class E; Brooksville, FL

    Science.gov (United States)

    2011-12-19

    ... Brooksville, FL, to accommodate a new air traffic control tower at Hernando County Airport This action... accommodate a new air traffic control tower at Hernando County Airport (76 FR 55298). Interested parties were... including 1,500 feet MSL within a 5.1-mile radius of Hernando County Airport, Brooksville, FL, and Class...

  14. 76 FR 55298 - Proposed Establishment of Class D and E Airspace and Amendment of Class E; Brooksville, FL

    Science.gov (United States)

    2011-09-07

    ... existing Class E airspace at Brooksville, FL. to accommodate a new air traffic control tower at Hernando County Airport. Controlled airspace is necessary for the support of air traffic operations at Hernando... surface at Hernando County Airport, Brooksville, FL. Controlled airspace is necessary to support...

  15. Lighting up Protons with MorphFl, a Fluorescein-Morpholine Dyad: An Experiment for the Organic Laboratory

    Science.gov (United States)

    Miller, Tyson A.; Spangler, Michael; Burdette, Shawn C.

    2011-01-01

    A two-period organic laboratory experiment that includes fluorescence sensing is presented. The pH-sensitive sensor MorphFl is prepared using a Mannich reaction between a fluorescein derivative and the iminium ion of morpholine. During the first laboratory, students prepare MorphFl. The second session begins with characterizing the sensor using…

  16. 77 FR 14032 - John H. Chafee Coastal Barrier Resources System; Lee County, FL, and Newport County, RI...

    Science.gov (United States)

    2012-03-08

    ... by Lee County, and 1 restaurant. The Service's assessment of 2011 aerial imagery estimates that the... Unit FL-70P. A new discrete segment is proposed for inclusion within Unit FL-70P to add lands owned by the Gasparilla Island Conservation and Improvement Association. This new discrete segment is located...

  17. 75 FR 20364 - Public Buildings Service; Key Largo Beacon Annex Site; Key Largo, FL; Transfer of Property

    Science.gov (United States)

    2010-04-19

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Public Buildings Service; Key Largo Beacon Annex Site; Key Largo, FL; Transfer of Property..., identified as Key Largo Beacon Annex Site, Key Largo, FL to the U.S. Fish and Wildlife Service, Department...

  18. A designated centre for people with disabilities operated by The Cheshire Foundation in Ireland, Mayo

    LENUS (Irish Health Repository)

    Hogan, A E

    2011-11-01

    The innate immune cells, invariant natural killer T cells (iNKT cells), are implicated in the pathogenesis of psoriasis, an inflammatory condition associated with obesity and other metabolic diseases, such as diabetes and dyslipidaemia. We observed an improvement in psoriasis severity in a patient within days of starting treatment with an incretin-mimetic, glucagon-like peptide-1 (GLP-1) receptor agonist. This was independent of change in glycaemic control. We proposed that this unexpected clinical outcome resulted from a direct effect of GLP-1 on iNKT cells.

  19. Holoceno marino en la península Potter, Isla 25 de Mayo, Antártida

    Directory of Open Access Journals (Sweden)

    R.A. del Valle

    2007-03-01

    Full Text Available La sucesión sedimentaria del Holoceno temprano expuesta en la terraza marina de 3,77 m s.n.m. en la costa sur de la caleta Potter (Isla 25 de Mayo/King George Island, islas Shetland del Sur, Antártida contiene invertebrados marinos, algas y huesos de foca y pingüino. Dataciones por radiocarbono de huesos de pingüino obtenidos en esta sucesión dieron edades de 7.562 a cal AP (años calibrados antes del Presente y 7.414 a cal AP. Las dataciones indican que los huesos están entre los restos de vertebrados más antiguos del Holoceno hallados en las Islas Shetland del Sur, y pueden ser consideradas como edades mínimas de ocupación por estas aves de las costas de las islas en el Holoceno temprano. Esto indica condiciones interglaciales en esa época, con situación clima/hielo marino similar a la presente y condiciones marinas estacionalmente abiertas.

  20. El primero de mayo en la ciudad de México en los tiempos de la revolución.

    Directory of Open Access Journals (Sweden)

    Anna Ribera Carb\\u00F3

    2006-01-01

    Full Text Available De entre las tradiciones inventadas por los trabajadores del mundo, la más exitosa es, sin duda, la del Primero de Mayo que sirvió para cohesionar a grupos obreros de distinta denominación ideológica y a crear entre ellos conciencia de clase como ninguna otra. En México la conmemoración empezó a realizarse de manera tardía. Fue en 1913 cuando se organizó en la ciudad de México la primera manifestación masiva a partir de la iniciativa de la Casa del Obrero Mundial fundada un año antes y vinculada al pensamiento anarcosindicalista. Fue justamente con esta manifestación que la clase obrera empezó a construir su propio espacio en la capital del país y convirtió a la Casa del Obrero Mundial en un elemento fundamental del entramado político de la Revolución Mexicana.

  1. Outcome prediction in home- and community-based brain injury rehabilitation using the Mayo-Portland Adaptability Inventory.

    Science.gov (United States)

    Malec, James F; Parrot, Devan; Altman, Irwin M; Swick, Shannon

    2015-01-01

    The objective of the study was to develop statistical formulas to predict levels of community participation on discharge from post-hospital brain injury rehabilitation using retrospective data analysis. Data were collected from seven geographically distinct programmes in a home- and community-based brain injury rehabilitation provider network. Participants were 642 individuals with post-traumatic brain injury. Interventions consisted of home- and community-based brain injury rehabilitation. The main outcome measure was the Mayo-Portland Adaptability Inventory (MPAI-4) Participation Index. Linear discriminant models using admission MPAI-4 Participation Index score and log chronicity correctly predicted excellent (no to minimal participation limitations), very good (very mild participation limitations), good (mild participation limitations), and limited (significant participation limitations) outcome levels at discharge. Predicting broad outcome categories for post-hospital rehabilitation programmes based on admission assessment data appears feasible and valid. Equations to provide patients and families with probability statements on admission about expected levels of outcome are provided. It is unknown to what degree these prediction equations can be reliably applied and valid in other settings.

  2. The cosmic background: evolution of infrared galaxies and dust properties. A lecture dedicated to the memory of Mayo Greenberg

    CERN Document Server

    Puget, J L; Dole, H; Puget, Jean-Loup; Lagache, Guilaine; Dole, Herve

    2004-01-01

    In recent years it became clear that a population of galaxies radiating most of their power in the far-infrared contribute an important part of the whole star formation activity in the universe. These galaxies emit up to 99% of their energy output in the infrared by dust. The optical properties of dust in galaxies are thus very important to understand this population. Mayo Greenberg who has brought many of the ideas underlying our understanding of the physics of interstellar dust has been a pioneer in predicting the important role of organic solid material formed on dust grains in molecular clouds and of potential importance of transient heating of very small particles. It appeared with the ISO data on galaxies and even more today with the first Spitzer data that these mechanisms are important globally for the observations of infrared galaxies at significant redshifts. The understanding of their evolution is one of the keys to the understanding of galaxy built up and evolution.

  3. Age-dependent vitreous separation from the macula in a clinic population

    Directory of Open Access Journals (Sweden)

    Syed Z

    2016-07-01

    Full Text Available Zahid Syed,1 Michael W Stewart2 1Georgetown University, Washington, DC, 2Department of Ophthalmology, Mayo School of Medicine, Jacksonville, FL, USA Background: Vitreous degeneration begins soon after birth and accelerates throughout life. Vitreous liquefaction with a slowly progressive separation of the posterior hyaloid from the peripheral macula usually leads to complete posterior vitreous detachment. The purpose of this study is to measure the age-related prevalence of partial vitreous separation and the length of residual vitreous adhesion in an ophthalmology clinic population. Methods: Patients examined by the senior author (MWS during a 6-month period were included in a retrospective chart review. Demographic data and spectral domain optical coherence tomography scan results were gathered. Data analysis with descriptive statistics focused on the prevalence and extent of partial vitreous separation. Results: The mean age of the study patients was 69.9 years, and 62% were phakic. The highest prevalence of partial posterior hyaloid separation from the internal limiting membrane (71.2% was seen in the 50- to 54-year age group. This prevalence rate steadily decreased to 5.6% in the 95- to 99-year age group. The prevalence of complete vitreous detachment as determined by slit-lamp biomicroscopy increased from 1.7% in the <50-year age group to a maximum of 29.2% in the 75- to 79-year group. The length of vitreomacular adhesion averaged 4.6 mm in the 50- to 54-year age group and steadily decreased to 2.1 mm in the 90- to 95-year group. Conclusion: Vitreomacular separation affects the majority of eyes in the sixth decade of life. The prevalence of partial vitreous separation decreases with advancing age, probably because an increasing number of these patients progress to complete posterior vitreous detachment. Keywords: optical coherence tomography, posterior hyaloid, posterior vitreous detachment, syneresis, vitreomacular adhesion, vitreous

  4. Los movimientos sociales en la transición democrática. El caso de las Madres de Plaza de Mayo: sentimiento y discurso

    Directory of Open Access Journals (Sweden)

    Martín D'ALESSANDRO

    2009-11-01

    Full Text Available RESUMEN: El presente artículo hace un repaso por el surgimiento y consolidación de Madres de Plaza de Mayo como movimiento social que inició sus actividades cuestionando la lucha antisubversiva emprendida por la dictadura militar argentina. Plantea además como este movimiento ha sufrido una radicalización de su discurso en la época de la transición a la democracia, cuando se desarrolla el enjuiciamiento de las Juntas Militares, y a partir de ese momento deciden enfrentarse al "sistema burgués". El discurso de Madres de Plaza de Mayo es inicialmente ético y moral para posteriormente adquirir matices de izquierda.ABSTRACT: This article analyzes the emergence and consolidation of the "Madres de Plaza de Mayo" as a social movement which initiated its action questioning the repressive policies led by the Argentine military dictatorship. It shows how the "Madres" undertook a radicalization of its discourse during the democratic transition, as the military "Juntas" were tried by Argentine courts. At this moment, the "Madres" dcided to struggle against the "bourgeois system." The discourse of the Madres was initially ethical and moral, and it became later left wing oriented.

  5. A designated centre for people with disabilities operated by Western Care Association, Mayo

    LENUS (Irish Health Repository)

    Brennan, Gráinne I

    2012-03-01

    Sequence type 22 (ST22) methicillin-resistant Staphylococcus aureus (MRSA) harboring staphylococcal cassette chromosome mec (SCCmec) IV (ST22-MRSA-IV) has predominated in Irish hospitals since the late 1990s. Six distinct clones of community-associated MRSA (CA-MRSA) have also been identified in Ireland. A new strain of CA-MRSA, ST772-MRSA-V, has recently emerged and become widespread in India and has spread into hospitals. In the present study, highly similar MRSA isolates were recovered from seven colonized neonates in a neonatal intensive care unit (NICU) in a maternity hospital in Ireland during 2010 and 2011, two colonized NICU staff, one of their colonized children, and a NICU environmental site. The isolates exhibited multiantibiotic resistance, spa type t657, and were assigned to ST772-MRSA-V by DNA microarray profiling. All isolates encoded resistance to macrolides [msr(A) and mpb(BM)] and aminoglycosides (aacA-aphD and aphA3) and harbored the Panton-Valentine leukocidin toxin genes (lukF-PV and lukS-PV), enterotoxin genes (sea, sec, sel, and egc), and one of the immune evasion complex genes (scn). One of the NICU staff colonized by ST772-MRSA-V was identified as the probable index case, based on recent travel to India. Seven additional hospital and CA-ST772-MRSA-V isolates recovered from skin and soft tissue infections in Ireland between 2009 and 2011 exhibiting highly similar phenotypic and genotypic characteristics to the NICU isolates were also identified. The clinical details of four of these patients revealed connections with India through ethnic background or travel. Our study indicates that hospital-acquired and CA-ST772-MRSA-V is currently emerging in Ireland and may have been imported from India on several occasions.

  6. Reglamento del Instituto para el Desarrollo Empresarial (INDEM), aprobado por el Consejo de Gobierno en sesión de 3 de diciembre de 2004 y modificado en sesión de 16 de mayo de 2013

    OpenAIRE

    2013-01-01

    El "Instituto universitario Carmen Vidal Ballester sobre desarrollo empresarial" pasó a denominarse "Instituto para el desarrollo empresarial (INDEM)" tras la sesión del Consejo de Gobierno de 16 de mayo de 2013.

  7. Influence of Fatty Liver on the Severity and Clinical Outcome in Acute Pancreatitis.

    Directory of Open Access Journals (Sweden)

    Chunfang Xu

    Full Text Available Acute pancreatitis (AP is a common disease in the department of gastroenterology with variable severity, from being mild and self-limited to severe and fatal. The early diagnosis and accurate prediction of AP severity are of great importance. Our primary observation showed that fatty liver (FL was frequently detected in patients with AP. In this retrospective study, we aimed to evaluate the relation between FL and the severity and outcomes of AP. The medical records of 2671 patients with AP were reviewed retrospectively, and characteristics of AP patients were recorded. FL was assessed by abdominal CT scan, and AP patients were categorized by the occurrence of FL for the analysis. The variation of mortality, clinical severity and the appearance of CT were analyzed between the non-FL group and FL groups. Compared with patients without FL, an obviously higher rate of death and higher frequency of severe AP (SAP and necrotizing AP (ANP were observed in patients with FL, as well as the incidence of local complications and systemic complications. Taking obesity into consideration, a higher rate of death and more severe AP were found in patients with FL, no matter whether they were obese or not. Alcoholic fatty liver (AFL and non-alcoholic fatty liver (NAFL were also separated for comparison in this study; the incidence of ANP and the clinical severity had no significant difference between the AFL and NAFL groups. In conclusion, FL could influence the severity and clinical outcome and may play a prognostic role in AP. This study is of clinical significance, because few reports have been previously issued on FL and AP.

  8. 75 FR 80372 - Proposed Amendment of Restricted Areas R-2907A and R-2907B, Lake George, FL; and R-2910...

    Science.gov (United States)

    2010-12-22

    ... Federal Aviation Administration 14 CFR Part 73 Proposed Amendment of Restricted Areas R-2907A and R-2907B, Lake George, FL; and R-2910, Pinecastle, FL AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... limits of restricted areas R-2907A and R-2907B, Lake George, FL; and restricted area R-2910, Pinecastle...

  9. St. Johns County, St. Augustine Inlet, FL, Report 1: Historical Analysis and Sediment Budget

    Science.gov (United States)

    2012-08-01

    Fenster and Dolan (1996) describe four criteria to identify the spatial extent of inlet processes on adjacent shorelines:  The cessation of...accretionary (or vice versa);  A change in slope of the cumulative shoreline change or volume change computed along the shoreline. Fenster and Dolan...Johns County; Office of Beaches & Coastal Systems. Florida Dept. of Environmental Protection Tallahassee, FL. Report No. BCS-00-03. Fenster , M., and R

  10. Utility of the Mayo End-Stage Liver Disease (MELD score in assessing prognosis of patients with alcoholic hepatitis

    Directory of Open Access Journals (Sweden)

    Patel Tushar

    2002-01-01

    Full Text Available Abstract Background Alcoholic hepatitis is characterized by acute, or acute-on-chronic hepatic failure and associated with a high mortality. Specific therapies should be considered for those at high risk of mortality. The Mayo End-Stage Liver Disease (MELD score is a marker of disease severity and mortality in persons with chronic alcoholic liver disease. Our aims were to assess the utility of the MELD score as a predictor of short-term mortality in persons with alcoholic hepatitis. Methods We assessed the utility of the MELD score and compared it with the Discriminant Function (DF as a predictor of mortality in 34 patients hospitalized with alcoholic hepatitis. Results The area under the curve of a receiver operating characteristic curve for the MELD score was 0.82 (confidence intervals 0.65–0.98, and for the DF was 0.86 (confidence intervals 0.70–1.00. However, the sensitivity and specificity in predicting 30-day mortality for a MELD score of greater than 11 was 86% and 81%, but for a DF greater than 32 was 86% and 48% respectively. The presence of ascites and bilirubin greater than 8 mg/dL were also highly predictive of mortality with a sensitivity of 71% and a specificity of 96%. Conclusions Alcoholic hepatitis remains associated with a high mortality in hospitalized patients. The MELD score performs as well as the DF in predicting mortality at 30 days. A MELD score of greater than 11, or the presence of both ascites and an elevated bilirubin greater than 8 mg/dL should prompt consideration of specific therapeutic interventions to reduce mortality.

  11. Cephalopoda as prey of juvenile Southern elephant seals at Isla 25 de Mayo/King George, South Shetland Islands

    Directory of Open Access Journals (Sweden)

    Luciana Burdman

    2015-03-01

    Full Text Available The aim of the present study was to enhance the knowledge of the feeding habits of the juvenile component of the population of Southern elephant seals [Mirounga leonina (Linnaeus, 1758] from Isla 25 de Mayo, South Shetland Islands, age class whose diet information is scarce. A total of 60 individuals were stomach lavaged in the spring - summer seasons of three consecutive years (2003, 2004 and 2005 of which 53.3 % (n = 32 presented food remnants. The Antarctic glacial squid Psychroteuthis glacialis Thiele, 1921 was the dominant prey taxon in terms of frequency of occurrence (68.7%, numerical abundance (60.1% and biomass (51.5%, contributing 84.1% to the total relative importance index. Other squid prey species of importance were Slosarczykovia circumantartica Lipinski, 2001 in terms of occurrence (37.5% and numerical abundance (14% and Moroteuthis knipovitchi Filippova, 1972 in terms of biomass (16%. All identified cephalopod prey taxa are distributed south of the Antarctic Polar Front, except for the squid Martialia hyadesi Rochebrune & Mabille, 1889 which has a circumpolar distribution associated to the Polar Frontal Zone. No significant differences in the sizes of P. glacialis preyed upon by elephant seals were found between sexes and years. However, significant interannual differences were found in the taxonomical composition of their diet. This would be associated with temporal changes in food availability at the foraging areas of seals, which in turn may have been influenced by changes in oceanographic conditions as a result of the El Niño Southern Oscillation (ENSO phenomenon that occurred during part of the study period. Furthermore, a differential response of males and females to this temporal variation was observed, with the former being also associated to a predation on octopods. This would suggest a sexual segregation in foraging habits of this species from the early stages of its life cycle.

  12. Photometry and Multipolar Magnetic Field Modeling of Polars: BY Camelopardalis and FL Ceti

    Directory of Open Access Journals (Sweden)

    P. A. Mason

    2015-02-01

    Full Text Available We present new broad band optical photometry of two magnetic cataclysmic variable stars, the asynchronous polar BY Camelopardalis and the short period polar FL Ceti. Observations were obtained at the 2.1-m Otto Struve Telescope of McDonald Observatory with 3s and 1s integration times respectively. In an attempt to understand the observed complex changes in accretion flow geometry observed in BY Cam, we performed full 3D MHD simulations assuming a variety of white dwarf magnetic field structures. We investigate fields with increasing complexity including both aligned and non-aligned dipole plus quadrupole field components. We compare model predictions with photometry at various phases of the beat cycle and find that synthetic light curves derived from a multipolar field structure are broadly consistent with optical photometry. FL Ceti is observed to have two very small accretion regions at the foot-points of the white dwarf’s magnetic field. Both accretion regions are visible at the same time in the high state and are about 100 degrees apart. MHD modeling using a dipole plus quadrupole field structure yields quite similar accretion regions as those observed in FL Ceti. We conclude that accretion flows calculated from MHD modeling of multi-polar magnetic fields produce synthetic light curves consistent with photometry of these magnetic cataclysmic variables.

  13. Clinical and differential utility of VEGF inhibitors in wet age-related macular degeneration: focus on aflibercept

    Directory of Open Access Journals (Sweden)

    Stewart MW

    2012-07-01

    Full Text Available Michael W StewartCollege of Medicine, Mayo Clinic, Jacksonville, FL, USAAbstract: Age-related macular degeneration (AMD has become a major public health problem and a leading cause of blindness in industrialized nations. AMD results from the ageing eye's inability to metabolize and dispose completely of photoreceptor outer segments and other waste products. As a result, lipids, particularly apolipoproteins, accumulate within Bruch's membrane, leading to chronic ischemia and inflammation. The subsequent upregulation of inflammatory cytokines and growth factors, including vascular endothelial growth factor (VEGF, induces the growth of neovascular membranes from the choriocapillaris into the subretinal or subretinal pigment epithelium spaces. To counter this, intravitreally administered drugs (pegaptanib, bevacizumab, ranibizumab that specifically target VEGF have become the standard treatment for exudative AMD. Aflibercept, a recently approved fusion protein, binds to all isoforms of both VEGF-A and placental growth factor with high affinity. Phase III trials showed that monthly or every other month injections of aflibercept prevent vision loss (fewer than 15 letters in 95% of patients. Additionally, aflibercept injections every 4 or 8 weeks produce average vision gains of 6.9 letters to 10.9 letters, comparable with those achieved with monthly ranibizumab. After one year of regularly administered aflibercept injections, patients required an average of only 4.2 injections during the second year. Aflibercept promises to decrease the injection frequency required for many patients and appears to serve as an effective “salvage” therapy for patients who respond poorly to other anti-VEGF drugs.Keywords: age-related macular degeneration, choroidal neovascularization, vascular endothelial growth factor, aflibercept, ranibizumab, bevacizumab, VEGF trap

  14. Validation of the AmpFlSTR« SEfiler Plus(TM) PCR Amplification kit for forensic STR analysis

    DEFF Research Database (Denmark)

    Fredslund, Stine Frisk; Mogensen, Helle Smidt; Morling, Niels

    2009-01-01

    Validation of the AmpFlSTR« SEfiler Plus(TM) PCR Amplification kit with 29 and 30 PCR cycles for forensic STR analysis demonstrated that the kit had fewer artefacts than the AmpFlSTR« SGM Plus(TM) kit (28 PCR cycles). The SEfiler Plus kit was more sensitive and devoid of colour artefacts, but sho......, but showed more stutters, drop-ins, drop-outs and allelic imbalances...

  15. Evaluation of afoxolaner chewables to control flea populations in naturally infested dogs in private residences in Tampa FL, USA

    OpenAIRE

    Dryden, Michael W.; Smith, Vicki; Chwala, Monica; Jones, Emery; Crevoiserat, Lisa; McGrady, Jennifer C.; Foley, Kaitlin M.; Patton, Paula R.; Hawkins, Anthony,; Carithers, Doug

    2015-01-01

    Background A study was conducted to evaluate the effectiveness of afoxolaner chewables to control flea populations in naturally infested dogs in private residences in Tampa FL, USA. Evaluations of on-animal and premises flea burdens, flea sex structure and fed-unfed premises flea populations were conducted to more accurately assess flea population dynamics in households. Methods Thirty seven naturally flea infested dogs in 23 homes in Tampa, FL were enrolled in the study and treated with afox...

  16. Topoisomerase I (Top1): a major target of FL118 for its antitumor efficacy or mainly involved in its side effects of hematopoietic toxicity?

    Science.gov (United States)

    Li, Fengzhi; Ling, Xiang; Harris, Danni L; Liao, Jianqun; Wang, Yuping; Westover, David; Jiang, Guohui; Xu, Bo; Boland, Patrick M; Jin, Chunyang

    2017-01-01

    FL118 is a novel camptothecin (CPT) analogue that possesses exceptional antitumor efficacy in human tumor animal models. To date, two CPT analogues, irinotecan and topotecan, have been approved by the FDA for cancer treatment. FL118 exhibits superior antitumor activity over irinotecan and topotecan, and effectively overcomes the irinotecan- or topotecan-resistant human tumors in animal models. Accordingly, FL118 selectively inhibits the expression of multiple cancer-associated proteins (survivin, Mcl-1, XIAP, cIAP2, MdmX). However, FL118 has hematopoietic toxicity similar to irinotecan and topotecan, suggesting that FL118’s hematopoietic toxicity may share a mechanism similar to irinotecan and topotecan. It is known that CPTs including irinotecan, SN-38 (active metabolite of irinotecan) and topotecan are topoisomerase I (Top1) inhibitors. However, the evidence from our studies failed to reveal that FL118 is a better Top1 inhibitor than SN-38. It was documented that Top1 expression level is positively associated with CPTs’ sensitivity. Low Top1 expression links to CPTs’ resistance. In contrast to these findings, we found that human colorectal tumor sensitivity to FL118 is irrelevant to the expression level of Top1 protein. FL118 can show high antitumor efficacy in Top1-negative tumors, while Top1 highly positive tumors can exhibit FL118 resistance. This suggests that the presence of Top1 target is not critical for FL118 antitumor activity. In other words, targeting Top1 by FL118 may not play a major role for its antitumor efficacy. However, studies indicate that FL118 can bind to, and inhibit Top1 activity. This raises the possibility that inhibition of Top1 by FL118 may predominantly be involved in hematopoietic toxicity, but not in FL118 antitumor activity. In this article, we will summarize existing observations and provide our up-to-date research results to support our opinion on this important topic.

  17. Salida de campo a La Tour du Valat y La Capeliére (La Camarga, Francia) el 21 de mayo de 1954

    OpenAIRE

    Valverde Gómez, José Antonio, 1926-2003

    2008-01-01

    Salida de campo a La Tour du Valat y La Capeliére (La Camarga, Francia) el 21 de mayo de 1954, de la que se anotaron observaciones sobre ranas, los siguientes peces: Anguilla anguilla (Anguila), "Carp. sol", Cyprinus carpio (Carpa) y Gambusia holbrooki (Gambusia), el reptil Natrix natrix (Culebra de collar, llamada Tropidonotus natrix por el autor), los siguientes mamíferos: Mus spicilegus (Ratón), Mustela nivalis (Comadreja) y Rattus norvegicus (Rata parda, llamada E.norvegicus por el autor)...

  18. Una aproximación a la demanda de los principales agregados monetarios en el Perú : Junio 1991-mayo 1997

    OpenAIRE

    Quispe Misaico, Zenón

    1998-01-01

    El presente informe resume los resultados de la estimación de la demanda por los principales agregados monetarios en el Perú en el período comprendido entre junio de 1991 y mayo de 1997. Luego de un examen exhaustivo de especificaciones alternativas para agregados monetarios de distintos grados de liquidez y para varios períodos muestrales se ha podido identificar al menos una relación de equilibrio de largo plazo para cada agregado monetario con relación al producto bruto interno (PBI), a la...

  19. Tratamiento de la escuela de las relaciones humanas (trabajos paralelos y posteriores a Elton Mayo) desde algunas perspectivas contemporáneas

    OpenAIRE

    Caicedo Botero, Natalia

    2010-01-01

    Se realizó una investigación de tipo exploratoria-descriptiva, con el objetivo primordial de analizar comparativamente desde un enfoque cualitativo el tratamiento que se le ha dado a la escuela de las relaciones humanas (trabajos paralelos y posteriores a Elton Mayo), desde algunas perspectivas contemporáneas y rescatar su papel protagónico en el surgimiento, desarrollo y evolución de la teoría organizacional, al igual que sus limitaciones y distorsiones; lo cual, implica un recorrido hist...

  20. ¿Quién ganó las elecciones autonómicas y municipales celebradas el 27 de mayo de 2007 en España?

    Directory of Open Access Journals (Sweden)

    Gema Sánchez Medero

    2008-01-01

    Full Text Available A lo largo de este artículo se analizan las elecciones municipales y autonómicas celebradas en España el 27 de mayo de 2007 para conocer cuál partido realmente salió reforzado para las próximas elecciones legislativas a celebrarse el 9 de marzo de 2008. Aunque en un principio pareciera que el gran ganador ha sido el Partido Popular, otros partidos, sin alcanzar las cifras de los dos grandes partidos nacionales, han obtenido resultados que les han convertido en piezas claves dentro del sistema político español.

  1. Prevalencia de fluorosis en niños de 10 a 14 años en el municipio de Cajibio de marzo a mayo de 2011

    OpenAIRE

    González Varona, María Andrea; Pazos Vivas, Gloria Alexandra

    2011-01-01

    Generar un informe dirigido a las entidades pertinentes (Secretaria de Salud) acerca de la prevalencia del estado de fluorosis de los niños de 10 - 14 años en el Municipio de Cajibio, que asisten a la consulta odontológica entre Marzo 1 a Mayo 30 de 2011, para con los hallazgos encontrados, iniciar el diseño de ideas que por medio de un trabajo conjunto, a largo plazo, permitan marcar las directrices en la prevención de la fluorosis y sus consecuencias.

  2. Bebidas embotelladas como fuentes adicionales de exposición a flúor

    Directory of Open Access Journals (Sweden)

    Loyola-Rodríguez Juan Pablo

    1998-01-01

    Full Text Available Objetivo. Evaluar y notificar la concentración de fluoruro en bebidas embotelladas que se consumen en la ciudad de San Luis Potosí, S.L.P., México y su implicación como factor de riesgo a fluorosis dental. Material y métodos. Se estudió el contenido de algunos productos de las dos compañías refresqueras más importantes de México y de otras dos locales. Las muestras se recolectaron de 10 lotes diferentes en el caso de los refrescos y de cinco lotes en el de los jugos, con tres muestras por lote, durante tres meses. La determinación de concentración de fluoruro se realizó mediante el método del electrodo de ión selectivo. Resultados. La concentración de flúor de muestras de diferentes plantas de compañías nacionales presentaron diferencias estadísticas significativas entre grupos (p< 0.05. La comparación de resultados entre compañías nacionales y locales también mostró diferencia estadística significativa (p< 0.05. Los diferentes jugos presentaron concentraciones de flúor elevadas. Conclusiones. La mayoría de las bebidas embotelladas que se consumen en San Luis Potosí presentaron niveles de flúor por arriba de la norma mexicana (0.7 ppm y pueden ser un factor de riesgo adicional de fluorosis dental en su población.

  3. Fortifi cation of white fl at bread with sprouted red kidney bean (Phaseolus vulgaris

    Directory of Open Access Journals (Sweden)

    Kiruthika Viswanathan

    2014-03-01

    Full Text Available Background. Protein quantity in diet including the digestibility and bioavailability of protein is of importance to eradicate undernutrition in developing countries. Bread protein is an incomplete source as it lacks an essential amino acid lysine. When they are combined with other plant foods like pulses and legumes, they become a complete source of protein. Since bread is most common staple food the objective of this study is to fortify bread with legumes in order to increase the total protein content of bread to 13-15% which is required to meet at least 1/3rd of protein requirement of an adult recommended daily allowance. Material and methods. Fortifi cation of fl at bread was done by adding sprouted red kidney bean flour (Phaseolus vulgaris at 5, 15 and 25% to white fl our. The composite bread was analysed for crude protein and in vitro protein digestibility using the Kjeldahl and pepsin-pancreatin method. Results. The protein content of raw beans showed trivial increase on soaking for 17h and sprouting for 3 days. On the other hand, a remarkable increase was observed in protein digestibility i.e., 8% and 11% respectively. The protein content of control and composite breads increased gradually at 1% and protein digestibility decreased by 12% from control. This is due to the presence of dietary fi bers which bind with protein and inhibit its digestibility. Conclusion. The study infers that sprouting the beans for 72 h did not show any remarkable increase in protein content but a signifi cant increase in invitro protein digestibility was observed. Overall, breads made using 15% legume fl our was comparatively equal in protein content, with overall acceptable quality.

  4. Flávio Suplicy de Lacerda: genealogia de um integrante da elite paranaense

    Directory of Open Access Journals (Sweden)

    Névio de Campos

    2013-09-01

    Full Text Available Este artigo objetiva discutir alguns aspectos da trajetória de Flávio Suplicy de Lacerda, enfatizando sua genealogia familiar (capital social e o capital cultural herdado e adquirido como trunfos utilizados para ocupar a reitoria da Universidade do Paraná, e as funções de Secretário do Estado paranaense, e de Ministro da Educação no governo militar de Castelo Branco. A hipótese afirma que o espírito de família e a herança cultural, se constituíram em estratégias utilizadas por Flávio de Lacerda para assumir funções de destaque no cenário cultural e político do Paraná e do Brasil, e foi discutida à luz dos conceitos de trajetória, estratégia, espírito de família e capital cultural herdado e adquirido, a partir de dados biográficos e autobiográficos. Esses dados foram tomados como produção de uma memória ou/e uma representação que buscava sacralizar essa personagem. As descrições biográficas, por sua vez, foram cruzadas com os contextos social e cultural, permitindo pôr em jogo o aparato teórico e o objeto empírico. Esta análise permite afirmar que as estruturas estruturadas se converteram em estruturas estruturantes na trajetória de Flávio de Lacerda, isto é, esse intelectual, ao interiorizar as estruturas estruturadas, incorporou o senso prático como sentido de jogo, como estratégia para ingressar no campo intelectual, assim como para ampliar seus espaços de ação nesse próprio campo. Em síntese, ao tomar os dados como tentativa de sacralização da trajetória de Flávio de Lacerda e convertê-los em produtos do processo dos contextos social e cultural, este artigo contribui ao entendimento da complexa relação entre o indivíduo e a sociedade, isto é, evidencia que os trunfos sociais e culturais funcionam como poderosas estratégias para assumir papeis de liderança nos campos político e cultural.

  5. Longitudinal Structure Function FL from Charm Structure Function F2c

    Institute of Scientific and Technical Information of China (English)

    B.Rezaei; G.R.Boroun

    2013-01-01

    We predict the effect of the charm structure function on the longitudinal structure function at small x.In NLO analysis we find that the hard Pomeron behavior gives a good description of FL and Fkc (k =2,L) at small x values.We conclude that a direct relation between FL∝ F2c would provide useful information on how to measure longitudinal structure function at high Q2 values.Having checked that this model gives a good description of the data,when compared with other models.

  6. Flüchtige Spuren in arabischen Quellen: Writing the Feminine

    Directory of Open Access Journals (Sweden)

    Barbara Winckler

    2002-11-01

    Full Text Available Writing the Feminine versammelt 13 Beiträge zur Frauengeschichte der arabischen Welt, insbesondere Andalusiens und des Maghreb der klassischen Zeit. Eine Vielzahl von Primärquellen werden daraufhin analysiert, welche Aussagen zu Handlungsspielräumen von Frauen – und ihren Grenzen – sich aus ihnen herauslesen lassen. Die unterschiedlichen Textsorten erhellen sich zum Teil auf überraschende Weise. Mag der Ertrag auch zunächst gering und die weiblichen Spuren flüchtig erscheinen, so stellt der Band doch einen wichtigen ersten Schritt dar, dem weitere folgen sollten.

  7. Electron structure of superheavy elements Uut, Fl and Uup ($Z$=113 to 115)

    CERN Document Server

    Dzuba, V A

    2016-01-01

    We use recently developed method of accurate atomic calculations which combines linearized single-double coupled cluster method with the configuration interaction technique to calculate ionisation potentials, excitation energies, static polarizabilities and valence electron densities for superheavy elements Uut, Fl and Uup ($Z$=113 to 115) and their ions. The accuracy of the calculations is controlled by comparing similar calculations for lighter analogs of the superheavy elements, Tl, Pb and Bi with experiment. The role of relativistic effects and correlations is discussed and comparison with earlier calculations is presented.

  8. Amphibian antimicrobial peptide fallaxin analogue FL9 affects virulence gene expression and DNA replication in Staphylococcus aureus.

    Science.gov (United States)

    Gottschalk, Sanne; Gottlieb, Caroline T; Vestergaard, Martin; Hansen, Paul R; Gram, Lone; Ingmer, Hanne; Thomsen, Line E

    2015-12-01

    The rapid rise in antibiotic-resistant pathogens is causing increased health concerns, and consequently there is an urgent need for novel antimicrobial agents. Antimicrobial peptides (AMPs), which have been isolated from a wide range of organisms, represent a very promising class of novel antimicrobials. In the present study, the analogue FL9, based on the amphibian AMP fallaxin, was studied to elucidate its mode of action and antibacterial activity against the human pathogen Staphylococcus aureus. Our data showed that FL9 may have a dual mode of action against S. aureus. At concentrations around the MIC, FL9 bound DNA, inhibited DNA synthesis and induced the SOS DNA damage response, whereas at concentrations above the MIC the interaction between S. aureus and FL9 led to membrane disruption. The antibacterial activity of the peptide was maintained over a wide range of NaCl and MgCl(2) concentrations and at alkaline pH, while it was compromised by acidic pH and exposure to serum. Furthermore, at subinhibitory concentrations of FL9, S. aureus responded by increasing the expression of two major virulence factor genes, namely the regulatory rnaIII and hla, encoding α-haemolysin. In addition, the S. aureus-encoded natural tolerance mechanisms included peptide cleavage and the addition of positive charge to the cell surface, both of which minimized the antimicrobial activity of FL9. Our results add new information about FL9 and its effect on S. aureus, which may aid in the future development of analogues with improved therapeutic potential.

  9. Study of neutron-deficient isotopes of Fl in the 239Pu, 240Pu + 48Ca reactions

    Science.gov (United States)

    Voinov, A. A.; Utyonkov, V. K.; Brewer, N. T.; Oganessian, Yu Ts; Rykaczewski, K. P.; Abdullin, F. Sh; Dmitriev, S. N.; Grzywacz, R. K.; Itkis, M. G.; Miernik, K.; Polyakov, A. N.; Roberto, J. B.; Sagaidak, R. N.; Shirokovsky, I. V.; Shumeiko, M. V.; Tsyganov, Yu S.; Subbotin, V. G.; Sukhov, A. M.; Sabelnikov, A. V.; Vostokin, G. K.; Hamilton, J. H.; Stoyer, M. A.; Strauss, S. Y.

    2016-07-01

    The results of the experiments aimed at the synthesis of Fl isotopes in the 239Pu + 48Ca and 240Pu + 48Ca reactions are presented. The experiment was performed using the Dubna gas-filled recoil separator at the U400 cyclotron. In the 239Pu+48Ca experiment one decay of spontaneously fissioning 284Fl was detected at 245-MeV beam energy. In the 240Pu+48Ca experiment three decay chains of 285Fl were detected at 245 MeV and four decays were assigned to 284Fl at the higher 48Ca beam energy of 250 MeV. The α-decay energy of 285Fl was measured for the first time and decay properties of its descendants 281Cn, 277Ds, 273Hs, 269Sg, and 265Rf were determined more precisely. The cross section of the 239Pu(48Ca,3n)284Fl reaction was observed to be about 20 times lower than those predicted by theoretical models and 50 times less than the value measured in the 244Pu+48Ca reaction. The cross sections of the 240Pu(48Ca,4-3n)284,285Fl at both 48Ca energies are similar and exceed that observed in the reaction with lighter isotope 239Pu by a factor of 10. The decay properties of the synthesized nuclei and their production cross sections indicate rapid decrease of stability of superheavy nuclei with departing from the neutron number N=184 predicted to be the next magic number.

  10. Crippin’ the Flâneur: Cosmopolitanism, and Landscapes of Tolerance

    Directory of Open Access Journals (Sweden)

    Fiona Kumari Campbell

    2010-04-01

    Full Text Available Cosmopolitanism, desire and the contracting of social relationships are enduring themes in both philosophy and social theory. In this paper I seek to explore these themes in order to ascertain what they might mean to disabled people and the ethos of ableism more generally. Modern Westernized life has since the Industrial Revolution been sited in cities fostering the growth of urban culture and an ethos of cosmopolitanism (Agamben, 2009; Beck, 2002; Cheah, 2006. The cosmopolitan outlook has become the signifier of that which is developed, advanced and civilized in society. The liberal project of the melting pot, of social tolerance is cast against the backdrop of city life (Brown, 2006.  The paper will first examine the trope of cosmopolitanism and disability including the place of ‘spaces’ for marginal peoples. Second, it will provide a perspective on the disabled flâneur (Campbell, 2009; Simmel, 1908; Young, 2005 who ambivalently claims ‘outsider-insidedness’ and finally the paper moves to consider the significant question of social inclusion and the government of aversion through the deployment of discourses of tolerance. Keywords: cosmopolitanism; social inclusion, community, flâneur, tolerance; biopolitics; disability

  11. The impact of Myriad and Mayo: will advancements in the biological sciences be spurred or disincentivized? (Or was biotech patenting not complicated enough?).

    Science.gov (United States)

    Gordon, Jennifer

    2014-12-11

    For years, purified and isolated naturally occurring biological substances of great medical importance--including genes--have been the subject of U.S. patents. Similarly, methods in which the detection of a biological substance (e.g., in a blood sample) dictates subsequent actions, as in disease diagnostics and treatment, have long enjoyed patent protection. However, two recent Supreme Court cases, Association for Molecular Pathology v. Myriad Genetics, Inc. (133 S. Ct. 2107) (2013) and Mayo Collaborative Services v. Prometheus Laboratories, Inc. (132 S. Ct. 1289) (2012), have shaken up the status quo of biotech patenting. The highest court in our land unanimously agreed with patent challengers that much of what we took for granted as patentable subject matter is not, as a matter of law, eligible for patenting after all. This review discusses the Myriad and Mayo cases, their impact on which biology-based innovations we may or may not continue to patent, and whether the altered status quo is benignly corrective or gravely disruptive. Is what happened here a good thing or not?

  12. Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.

    Science.gov (United States)

    Dias, Marcio V B; Huang, Fanglu; Chirgadze, Dimitri Y; Tosin, Manuela; Spiteller, Dieter; Dry, Emily F V; Leadlay, Peter F; Spencer, Jonathan B; Blundell, Tom L

    2010-07-16

    The thioesterase FlK from the fluoroacetate-producing Streptomyces cattleya catalyzes the hydrolysis of fluoroacetyl-coenzyme A. This provides an effective self-defense mechanism, preventing any fluoroacetyl-coenzyme A formed from being further metabolized to 4-hydroxy-trans-aconitate, a lethal inhibitor of the tricarboxylic acid cycle. Remarkably, FlK does not accept acetyl-coenzyme A as a substrate. Crystal structure analysis shows that FlK forms a dimer, in which each subunit adopts a hot dog fold as observed for type II thioesterases. Unlike other type II thioesterases, which invariably utilize either an aspartate or a glutamate as catalytic base, we show by site-directed mutagenesis and crystallography that FlK employs a catalytic triad composed of Thr(42), His(76), and a water molecule, analogous to the Ser/Cys-His-acid triad of type I thioesterases. Structural comparison of FlK complexed with various substrate analogues suggests that the interaction between the fluorine of the substrate and the side chain of Arg(120) located opposite to the catalytic triad is essential for correct coordination of the substrate at the active site and therefore accounts for the substrate specificity.

  13. Identification and positional distribution analysis of transcription factor binding sites for genes from the wheat fl-cDNA sequences.

    Science.gov (United States)

    Chen, Zhen-Yong; Guo, Xiao-Jiang; Chen, Zhong-Xu; Chen, Wei-Ying; Wang, Ji-Rui

    2017-06-01

    The binding sites of transcription factors (TFs) in upstream DNA regions are called transcription factor binding sites (TFBSs). TFBSs are important elements for regulating gene expression. To date, there have been few studies on the profiles of TFBSs in plants. In total, 4,873 sequences with 5' upstream regions from 8530 wheat fl-cDNA sequences were used to predict TFBSs. We found 4572 TFBSs for the MADS TF family, which was twice as many as for bHLH (1951), B3 (1951), HB superfamily (1914), ERF (1820), and AP2/ERF (1725) TFs, and was approximately four times higher than the remaining TFBS types. The percentage of TFBSs and TF members showed a distinct distribution in different tissues. Overall, the distribution of TFBSs in the upstream regions of wheat fl-cDNA sequences had significant difference. Meanwhile, high frequencies of some types of TFBSs were found in specific regions in the upstream sequences. Both TFs and fl-cDNA with TFBSs predicted in the same tissues exhibited specific distribution preferences for regulating gene expression. The tissue-specific analysis of TFs and fl-cDNA with TFBSs provides useful information for functional research, and can be used to identify relationships between tissue-specific TFs and fl-cDNA with TFBSs. Moreover, the positional distribution of TFBSs indicates that some types of wheat TFBS have different positional distribution preferences in the upstream regions of genes.

  14. Hematopoietic transcription factor GATA-2 promotes upregulation of alpha globin and cell death in FL5.12 cells.

    Science.gov (United States)

    Brecht, K; Simonen, M; Kamke, M; Heim, J

    2005-10-01

    Recently we showed that alpha globin is a novel pro-apoptotic factor in programmed cell death in the pro-B cell line, FL5.12. Alpha globin was also upregulated in various other cell lines after different apoptotic stimuli. Under withdrawal of IL-3, overexpression of alpha globin accelerated apoptosis in FL5.12. Here, we have studied how transcription of alpha globin is placed in the broader context of apoptosis. We used Affymetrix chip technology and RT QPCR to compare expression patterns of FL5.12 cells growing with or without IL-3 to search for transcription factors which were concomitantly upregulated with alpha globin. The erythroid-specific transcription factor GATA-2 was the earliest and most prominently upregulated candidate. GATA-1 was expressed at low levels and was weakly induced while GATA-3 was completely absent. To evaluate the influence of GATA-2 on alpha globin expression and cell viability we overexpressed GATA-2 in FL5.12 cells. Interestingly, high expression of GATA-2 resulted in cell death and elevated alpha globin levels in FL5.12 cells. Transduction of antisense GATA-2 prevented both increase of GATA-2 and alpha globin under apoptotic conditions and delayed cell death. We suggest a role of GATA-2 in apoptosis besides its function in maintenance and proliferation of immature hematopoietic progenitors.

  15. Amphibian antimicrobial peptide fallaxin analogue FL9 affects virulence gene expression and DNA replication in Staphylococcus aureus

    DEFF Research Database (Denmark)

    Gottschalk, Sanne; Gottlieb, Caroline Trebbien; Vestergaard, Martin;

    2015-01-01

    antimicrobials. In the present study, the analogue FL9, based on the amphibian AMP fallaxin, was studied to elucidate its mode of action and antibacterial activity against the human pathogen Staphylococcus aureus. Our data showed that FL9 may have a dual mode of action against S. aureus. At concentrations around...... the MIC, FL9 bound DNA, inhibited DNA synthesis and induced the SOS DNA damage response, whereas at concentrations above the MIC the interaction between S. aureus and FL9 led to membrane disruption. The antibacterial activity of the peptide was maintained over a wide range of NaCl and MgCl2 concentrations......-encoded natural tolerance mechanisms included peptide cleavage and the addition of positive charge to the cell surface, both of which minimized the antimicrobial activity of FL9. Our results add new information about FL9 and its effect on S. aureus, which may aid in the future development of analogues...

  16. Stemcell Information: SKIP000919 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available a Thatava Tayaramma Thatava Department of Molecular Medicine, Mayo Clinic Department... of Molecular Medicine, Mayo Clinic ... Information Only Department of Molecular Medicine, Mayo Clinic Department

  17. Stemcell Information: SKIP000918 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available a Thatava Tayaramma Thatava Department of Molecular Medicine, Mayo Clinic Department... of Molecular Medicine, Mayo Clinic ... Information Only Department of Molecular Medicine, Mayo Clinic Department

  18. Ponce de Leon Inlet, FL: An Integrated Hydrodynamic and Morphologic Assessment of Design Alternatives using the U.S. Army Corps of Engineers’ Coastal Modeling System

    Science.gov (United States)

    2009-07-01

    Ponce de Leon Inlet, FL: An Integrated Hydrodynamic and Morphologic Assessment of Design Alternatives using the U.S. Army Corps of Engineers...DATES COVERED - 4. TITLE AND SUBTITLE Ponce de Leon Inlet, FL: An Integrated Hydrodynamic and Morphologic Assessment of Design Alternatives...SUPPLEMENTARY NOTES 14. ABSTRACT Shoaling and channel migration at Ponce de Leon Inlet, FL, have caused persistently hazardous navigation conditions

  19. The eff ect of addition of selected vegetables on the microbiological, textural and fl avour profi le properties of yoghurts

    Directory of Open Access Journals (Sweden)

    Dorota Najgebauer-Lejko

    2015-03-01

    Full Text Available Background. Vegetables, apart from having high nutritional value, also contain considerable amounts of dietary fi bre and other components, which may affect physico-chemical properties of fermented milks, e.g. viscosity, texture, susceptibility to syneresis, fl avour profi le etc. The present work was established to study the effect of selected vegetables addition on the rheological, textural, microbiological and fl avour profi le parameters of yoghurts. Material and methods. The vegetable preparations (carrot, pumpkin, broccoli and red sweet pepper were added (10% w/w to the processed cow’s milk fermented with DVS yoghurt culture. Texture profi le analysis, determination of viscosity, susceptibility to syneresis and descriptive fl avour evaluation were conducted at the 1st, 7th and 14th day after production. Additionally, microbiological studies were performed for 28 days, at 7-day intervals. Results. The highest apparent viscosity and adhesiveness were obtained for the carrot yoghurt, whereas yoghurt with pumpkin was the least susceptible to syneresis. The other texture parameters were not affected by the addition of vegetables. Broccoli and red sweet pepper fl avours were dominating in the fermented milks fortifi ed with these vegetables, whereas carrot and pumpkin fl avours were less distinctive. Yoghurt supplemented with red sweet pepper got the highest sensoric acceptability. The number of starter bacteria was not infl uenced by the vegetable additives, except for pumpkin yoghurt, which contained lower population of lactobacilli. Conclusions. Among all tested vegetables, carrot additive had the greatest potential to improve yoghurt structure, whereas red sweet pepper imparted the most acceptable fl avour.

  20. Flüssiges unterkühltes Grenzflächenwasser in der Marsoberfläche

    OpenAIRE

    Lorek, Andreas

    2008-01-01

    Diese Arbeit befasst sich mit den noch ungeklärten aber zentralen Fragen der Marsforschung, wie viel flüssiges Grenzflächenwasser sich in den oberen Schichten mittlerer und niederer Breiten befinden kann und wie viel davon bei Temperaturen unter 0 °C in flüssiger Form vorliegt. Die Erfassung des Wassergehaltes und des Aggregatzustandes in Böden erfolgte über die Messung der Dielektrizitätskonstante der Böden im Temperaturbereich 25 °C bis -70 °C. Zwei dielektrische Messsysteme wurden zur B...

  1. Diluvios de grandeza: agua, territorio y poder en el río Mayo en el noroeste de México, 1880-1910

    Directory of Open Access Journals (Sweden)

    Jeffrey M. Banister

    2012-01-01

    Full Text Available El actual distrito de riego 038 o valle del Mayo, que forma parte del espacio de riego del noroeste de México, surge de luchas históricas por construir un orden oficial en un mundo diverso de signos, símbolos, procesos, lugares y personas. Es el hogar ancestral de los yoremes (mayos, un grupo indígena para el que la colonización y el desarrollo agrícola han significado la pérdida de autonomía y de la movilidad estacional que requieren para subsistir en un terreno árido. Es el lugar donde nació el presidente Álvaro Obregón, otrora productor de garbanzo, que transformó las prácticas de riego de fines del siglo xix en las leyes e instituciones para la administración del agua del siglo xx. Reconfigurar el territorio con el fin de centralizar ("federalizar" los recursos hídricos ha probado ser excesivamente difícil en la zona del Mayo, pero esto fue así en particular al inicio del proceso de federalización, una época de modernización dinámica bajo la dirección del presidente Porfirio Díaz (1876-1910. La investigación sobre la política hidráulica de México, con algunas importantes excepciones, ha tendido a enfocarse en la centraliza- ción. Los estudiosos le han prestado menor atención a los momentos y lugares en los que el agua escapa al control de las autoridades. Este trabajo explora la importancia de la administración del agua (y más ampliamente la formación del Estado a finales del siglo xix, en vísperas de la Revolución Mexicana de 1910, como una serie continua, siempre incipiente de derechos y proyectos relativos a las tierras. Entender las debilidades e incompetencias de dichos proyectos ofrece un discernimiento crucial acerca de la política hidráulica posrevolucionaria o contemporánea.

  2. SU-E-J-171: Evaluation of Cervical Spine and Mandible Reproducibility of the CDR Mayo Mold and Civco Type-S Head and Neck Immobilization Systems.

    Science.gov (United States)

    Chungbin, S

    2012-06-01

    To evaluate the cervical spine (c-spine) and mandible reproducibility of the CDR Mayo Mold and Civco Type-S head and neck immobilization system using Mosaiq Setup Intelligence Curve Image Registration Methods: Patients were immobilized with either the Mayo Mold or Civco Type-S head and neck immobilization systems. Using curve image registration tools in Mosaiq, the c-spine and mandible were outlined. For each lateral image, two separate image registrations were performed using an initial kV image as reference - 1) c-spine only 2) mandible only. To evaluate the relative difference between the c-spine and mandible position, the mandible image registration results were subtracted from the c-spine image registration results. To evaluate whether the initial difference between the planning CT and the first kV setup image is larger than subsequent daily imaging variations, the difference in the image registration of the DRR was compared to the variation in subsequent image registrations. The degree of neck flexion was determined by observing the amount of mismatch between the upper and lower cervical spine after the pitch correction. During the first weeks of treatment, there was minimal difference in the image registration results for both the c-spine and mandible individually, and in the relative difference between them. For neck flexion, the Mayo Mold system demonstrated 82.6% minimal difference and 3.8% significant difference between the alignment of upper and lower c spine, vs. 84% and 5.2% for the S frame. For some patients, there is a greater difference between the DRR and the initial kV image registration than the variation in registrations for subsequent daily imaging. Preliminary results indicate minimal difference in the c-spine and mandible reproducibility between the two immobilization systems during the first weeks of treatment. Further analysis of whether this minimal difference remains consistent throughout the entire course and treatment and with greater

  3. ¿Agua de consumo humano con o sin flúor?

    Directory of Open Access Journals (Sweden)

    Jaime-Gonzáles-Murillo

    2013-01-01

    Full Text Available Los beneficios de la utilización de Flúor en la salud dental han sido convencionalmente aceptados, sinembargo en la actualidad nuevas investigaciones en salud humana revelan la urgencia por evitar la ingestión de Fluor al punto de inclusive modificar programas de salud e implementar nuevas investigaciones. Los gobiernos como Canadá, Estados Unidos Chile, Países Europeos y Asiáticos que han invertido cifras millonarias en Fluorización pública; ahora deben modificar sus programas e investigar daños causados. Por este motivo la dotación de agua deberá seguir estas directrices.

  4. Impacts of the 2010 Haitian earthquake in the diaspora: findings from Little Haiti, Miami, FL.

    Science.gov (United States)

    Kobetz, Erin; Menard, Janelle; Kish, Jonathan; Bishop, Ian; Hazan, Gabrielle; Nicolas, Guerda

    2013-04-01

    In January 2010, a massive earthquake struck Haiti resulting in unprecedented damage. Little attention, however, has focused on the earthquake's mental health impact in the Haitian diaspora community. As part of an established community-based participatory research initiative in Little Haiti, the predominately Haitian neighborhood in Miami, FL, USA, community health workers conducted surveys with neighborhood residents about earthquake-related losses, coping strategies, and depressive/traumatic symptomology. Findings reveal the earthquake strongly impacted the diaspora community and highlights prominent coping strategies. Following the earthquake, only a small percentage of participants self-reported engaging in any negative health behaviors. Instead, a majority relied on their social networks for support. This study contributes to the discourse on designing culturally-responsive mental health initiatives for the Haitian diaspora and the ability of existing community-academic partnerships to rapidly adapt to community needs.

  5. Alligator diet in relation to alligator mortality on Lake Griffin, FL

    Science.gov (United States)

    Rice, A.N.; Ross, J.P.; Woodward, A.R.; Carbonneau, D.A.; Percival, H.F.

    2007-01-01

    Alligator mississippiensis (American Alligators) demonstrated low hatch-rate success and increased adult mortality on Lake Griffin, FL, between 1998 and 2003. Dying Lake Griffin alligators with symptoms of poor motor coordination were reported to show specific neurological impairment and brain lesions. Similar lesions were documented in salmonines that consumed clupeids with high thiaminase levels. Therefore, we investigated the diet of Lake Griffin alligators and compared it with alligator diets from two lakes that exhibited relatively low levels of unexplained alligator mortality to see if consumption of Dorosoma cepedianum (gizzard shad) could be correlated with patterns of mortality. Shad in both lakes Griffin and Apopka had high levels of thiaminase and Lake Apopka alligators were consuming greater amounts of shad relative to Lake Griffin without showing mortality rates similar to Lake Griffin alligators. Therefore, a relationship between shad consumption alone and alligator mortality is not supported.

  6. Péptido derivado de TrkB-FL y su uso como neuroprotector

    OpenAIRE

    Díaz-Guerra, Margarita; Sánchez Tejeda, Gonzalo; Gómez Vidaurre, Oscar; Ayuso Dolado, Sara

    2015-01-01

    [ES] La presente invención hace referencia a un péptido neuroprotector, caracterizado por que consiste en15 aminoácidos de la secuencia de TrkB-FL humana correspondiente a las posiciones 458 hasta 472 de la secuencia canónica y que es capaz de ejercer un efecto neuroprotector al aumentar el tiempode respuesta pro-supervivencia. Asímismo, en la presente invención, se protege el uso de dicho péptido para prevenir y/o tratar el daño neuronal en mamíferos causado por una patología del sistema ner...

  7. A Internet das Coisas Vistas: medianeras, flâneur, zappeur

    Directory of Open Access Journals (Sweden)

    Émile Cardoso Andrade

    2013-12-01

    Full Text Available Extensão do curta-metragem homônimo escrito por Gustavo Taretto em 2004 e filmado em 2005, Medianeras é uma reflexão simples e espirituosa sobre a falta de sincronia do destino das pessoas e sobre o impacto da tecnologia no dia a dia delas. Narrar a experiência solitária e anônima dentro da cidade é uma tradição da sociedade industrial que não se perdeu com a explosão e popularização da rede mundial de computadores a partir da década de 1990. Mas, agora, estamos diante do flâneur digital.

  8. Fenilefrina intracamerular en el síndrome del iris flácido intraoperatorio

    OpenAIRE

    Ruiz Vargas, Arturo

    2011-01-01

    La incidència d'hipertròfia benigna de pròstata és aproximadament d'un 50 % en pacients majors de 50 anys. La Tamsulosina és el medicament més prescrit per aquesta dolència i la principal causa del síndrome d'iris flàccid intraoperatori a la cirurgia de cataractes. Els nostres dos estudis han sigut; per una banda, avaluar la toxicitat corneal i afectació cardíaca de Fenilefrina intracamerular a una concentració de 2,5% respecte la pauta de dilatació tòpica estàndard al nostre centre, i per l'...

  9. Expression of Trypanosoma cruzi surface antigen FL-160 is controlled by elements in the 3' untranslated, the 3' intergenic, and the coding regions.

    Science.gov (United States)

    Weston, D; La Flamme, A C; Van Voorhis, W C

    1999-07-30

    The FL-160 surface antigen gene family of T. cruzi consists of hundreds of members of 160 kDa glycoproteins expressed in trypomastigotes, but not in epimastigotes. Steady-state levels of FL-160 mRNA were 80 to 100-fold higher in trypomastigotes than in epimastigotes, yet transcription rates were equivalent between the lifecycle stages. Luciferase reporter constructs demonstrated that the 3' untranslated region (UTR) and intergenic region (IR) following the coding sequence of FL-160 was sufficient to generate 8-fold higher luciferase expression in trypomastigotes compared with epimastigotes. Transfection of 3' UTR/IR deletion constructs revealed cis-acting elements which conferred a trypomastigote-specific expression pattern similar to that of FL-160. Parasites treated with translation and transcription inhibitors, cyclohexamide and Actinomycin D, respectively, displayed a stage-specific pattern of FL-160 mRNA degradation. Epimastigotes, but not trypomastigotes, treated with the inhibitors accumulated a 1.4 Kb FL-160 cleavage product. The cleavage site mapped to a 31 base poly-purine tract in the FL-160 coding region. The first 526 aa of FL-160, containing the 31 base poly-purine tract and several smaller tracts, were fused to green fluorescent protein (GFP) and expressed from the T. cruzi tubulin locus. Stable transformants expressed 4-fold more FL-160:GFP fusion mRNA and 12-fold more fusion protein in the trypomastigote stage than in the epimastigote stage suggesting post-transcriptional and translational control elements. These data reveal at least two distinct control mechanisms for trypomastigote-specific expression of FL-160 surface glycoproteins, one involving the 3' UTR/IR and one involving the coding region of FL-160.

  10. La violencia de género y el principio de igualdad ante la Ley (Comentario a la STC 59/2008, de 14 de mayo)

    OpenAIRE

    2010-01-01

    En este artículo se examina la sentencia del Tribunal Constitucional español 59/2008, de 14 de mayo, que desestima la cuestión de inconstitucionalidad por vulneración del mandato de igualdad en relación a la discriminación por razón de sexo que contempla el artículo 153.1 del Código Penal, en su redacción dada por el artículo 37 de la Ley Orgánica 1/2004, de 28 de diciembre, de Medidas de Protección Integral contra la Violencia de Género. Para llevar a cabo este análisis, se realizará una bre...

  11. Chemistry and origin of the Mayo Kila sapphires, NW region Cameroon (Central Africa): Their possible relationship with the Cameroon volcanic line

    Science.gov (United States)

    Paul Mbih, Kemeng; Meffre, Sebastien; Yongue, Rose Fouateu; Kanouo, Nguo Sylvestre; Jay, Thomson

    2016-06-01

    Mineralogical, chemical and geochronological studies constrained the origin of sapphires from Mayo Kila, Northwest Cameroon. The sapphires are mostly blue, with sizes ranging from 2 to 5 mm. The pale blue grains are transparent, whereas, other corundums are transparent to translucent and/or opaque. The sapphires are dominantly euhedral to sub-hedral with few polished lustrous grains, acquired features during moderate to short distance transport from a proximal source rock. Solid inclusions are limited to rutile and zircon. Trace element analysis of sapphires shows significant concentration (in ppm) in some elements: Fe (2208-14,473), Ti (82-1783), Ga (77-512), Mg (0.9-264.9), Cr (b.d.l -168) and V (1.3-82). The other elements (e.g. Sn, Nb, Ta, Th, Zr, Ni, Ce) are generally below 10 ppm. The calculated ratios for some of the selected elements show an extreme variation: Fe/Mg (43-3043), Fe/Ti (2-76), Ti/Mg (1-328), and Ga/Mg (0.4-363). They are dominantly corundum crystallized in alkaline magma (s) with few from metamorphic source (s). Trace elemental features with Hf (13,354-26,238 ppm), Th (4018-45,584 ppm) and U (7825-17,175 ppm), and Th/U (0.39-2.65) found in zircon inclusions are compatible with quantified values in magmatic crystallized zircons. The Cenozoic age (mean of 30.78 ± 0.28 Ma) obtained for zircon inclusions is close to the age of some igneous rocks found within the Cameroon Volcanic Line (e.g. rocks of the Mount Oku: 31-22 Ma), showing the same period of formation. The most probable source of the zircon host sapphires is the Oku Mountain located SW of Mayo Kila.

  12. De la resistencia a la integración. Las transformaciones de la Asociación Madres de Plaza de Mayo en la "era Kirchner" From the Resistance to the Integration. The Transformations of the Mothers of Plaza de Mayo in the "Age Kirchner"

    Directory of Open Access Journals (Sweden)

    Enrique Andriotti Romanin

    2012-12-01

    Full Text Available A partir de la presidencia de Néstor Kirchner algunos organismos del movimiento de derechos humanos de Argentina decidieron progresivamente acompañar las políticas de Estado y, en algunos casos, incorporarse a las estructuras gubernamentales. Entre estos se destaca la Asociación Madres de Plaza de Mayo de Argentina, que históricamente ha confrontado con el Estado y los distintos gobiernos, tras el retorno de la democracia en 1983. En este trabajo se analizan algunos aspectos de los cambios en las estrategias, marcos de acción colectiva y claves interpretativas acerca del Estado y la política que elabora esta asociación durante el periodo 2003-2010, con el objetivo de comprender los factores que explican el pasaje de una estrategia dominante de confrontación a una de integración al Estado por parte de esta organización, tal vez la más emblemática del movimiento de derechos humanos de Argentina. Para su realización se utilizan fuentes de información primaria, especialmente discursos y documentos de la organización seleccionados entre la enorme cantidad de material que ha producido la Asociación Madres de Plaza de Mayo, y fuentes secundarias como diarios y revistas argentinas de circulación nacional.From the presidency of Nestor Kirchner some agencies of the human rights movement in Argentina decided to progressively follow state politics and, in some cases, be incorporated into government structures. These highlighted the Mothers of Plaza de Mayo, which had historically confronted with the state and the various governments since the return of democracy in 1983.This paper discusses some aspects of the changes in strategies, collective action frames and key interpretations about state and politics that produced this association during the period 2003-2010 with the aim of: Understanding the factors behind the passage of a dominant strategy of confrontation to one of integration to the state by the organization, perhaps, the most

  13. 76 FR 30822 - Technical Amendment to List of User Fee Airports: Addition of Naples Municipal Airport, Naples, FL

    Science.gov (United States)

    2011-05-27

    ... Airports: Addition of Naples Municipal Airport, Naples, FL AGENCY: U.S. Customs and Border Protection... user fee airports to reflect the recent user fee airport designation for Naples Municipal Airport, in Naples, Florida. User fee airports are those airports which, while not qualifying for designation...

  14. Increasing Language Awareness and Self-Efficacy of FL Students Using Self-Assessment and the ACTFL Proficiency Guidelines

    Science.gov (United States)

    Kissling, Elizabeth M.; O'Donnell, Mary E.

    2015-01-01

    This study describes how oral language was assessed in an advanced-level college foreign language (FL) conversation course. Learners used the American Council on the Teaching of Foreign Languages Proficiency Guidelines to guide self-analyses of their oral production at intervals throughout the course. The intent was to provide opportunities for…

  15. Assessment of Intercultural Communicative Competence in FL Education: A Survey on EFL Teachers' Perception and Practice in China

    Science.gov (United States)

    Gu, Xiaole

    2016-01-01

    The intercultural approach to language teaching, intercultural communicative language teaching, has emerged in response to the limitations of communicative language teaching. As a result, the ultimate goal of foreign language (FL) education is being shifted from communicative competence to intercultural communicative competence (ICC). In China,…

  16. Exploring Language Learning Strategy Transfer between Greek L2 and English FL in Case of Early Adolescent Multilinguals

    Science.gov (United States)

    Mitits, Lydia; Gavriilidou, Zoe

    2016-01-01

    This study compares language learning strategy (LLS) use between Greek L2 and English FL and a possible variation in the frequency and type of LLSs employed in the two languages in order to depict the strategic profiles of the multilingual learners aged 12-15 (n = 307). It also observes the effect of gender in relation to a second vs. foreign…

  17. How Spanish Teachers and Their Beginning-Level University Students Perceive FL Teaching Practices--Ideally and Concretely

    Science.gov (United States)

    Brown, Alan V.

    2009-01-01

    The increased dependence on student evaluations to assess instructional effectiveness at the post-secondary level manifests the growing importance the field places on students' perspectives of teaching and learning (Seldin 1993). Horwitz (1990), Kern (1995), and Schulz (1996) claim that mismatches between FL students' and teachers' expectations of…

  18. 78 FR 19194 - P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying Export Privileges

    Science.gov (United States)

    2013-03-29

    ... Bureau of Industry and Security P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying... Division, P&P Computers (``P&P'') was convicted of violating the International Emergency Economic Powers... IEEPA and the Iranian Transactions Regulations by exporting computer and related equipment from...

  19. 78 FR 33969 - Special Local Regulations; Daytona Beach Grand Prix of the Sea, Atlantic Ocean; Daytona Beach, FL

    Science.gov (United States)

    2013-06-06

    ... SECURITY Coast Guard 33 CFR Part 100 RIN 1625-AA08 Special Local Regulations; Daytona Beach Grand Prix of the Sea, Atlantic Ocean; Daytona Beach, FL AGENCY: Coast Guard, DHS. ACTION: Temporary final rule... east of Daytona Beach, Florida, during the Daytona Beach Grand Prix of the Sea, a series of...

  20. Exploring Language Learning Strategy Transfer between Greek L2 and English FL in Case of Early Adolescent Multilinguals

    Science.gov (United States)

    Mitits, Lydia; Gavriilidou, Zoe

    2016-01-01

    This study compares language learning strategy (LLS) use between Greek L2 and English FL and a possible variation in the frequency and type of LLSs employed in the two languages in order to depict the strategic profiles of the multilingual learners aged 12-15 (n = 307). It also observes the effect of gender in relation to a second vs. foreign…

  1. 33 CFR 334.595 - Atlantic Ocean off Cape Canaveral; 45th Space Wing, Cape Canaveral Air Force Station, FL...

    Science.gov (United States)

    2010-07-01

    ...; 45th Space Wing, Cape Canaveral Air Force Station, FL; restricted area. 334.595 Section 334.595.... The regulations in this section shall be enforced by the Commander, 45th Space Wing, Patrick Air Force... AND RESTRICTED AREA REGULATIONS § 334.595 Atlantic Ocean off Cape Canaveral; 45th Space Wing,...

  2. 76 FR 26931 - Safety Zone; Second Annual Space Coast Super Boat Grand Prix, Atlantic Ocean, Cocoa Beach, FL

    Science.gov (United States)

    2011-05-10

    ... Prix, Atlantic Ocean, Cocoa Beach, FL AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY... Cocoa Beach, Florida during the Second Annual Space Coast Super Boat Grand Prix. The Second Annual Space... will be held on the waters of the Atlantic Ocean east of Cocoa Beach, Florida. Approximately 30...

  3. How Spanish Teachers and Their Beginning-Level University Students Perceive FL Teaching Practices--Ideally and Concretely

    Science.gov (United States)

    Brown, Alan V.

    2009-01-01

    The increased dependence on student evaluations to assess instructional effectiveness at the post-secondary level manifests the growing importance the field places on students' perspectives of teaching and learning (Seldin 1993). Horwitz (1990), Kern (1995), and Schulz (1996) claim that mismatches between FL students' and teachers' expectations of…

  4. Assessment of Intercultural Communicative Competence in FL Education: A Survey on EFL Teachers' Perception and Practice in China

    Science.gov (United States)

    Gu, Xiaole

    2016-01-01

    The intercultural approach to language teaching, intercultural communicative language teaching, has emerged in response to the limitations of communicative language teaching. As a result, the ultimate goal of foreign language (FL) education is being shifted from communicative competence to intercultural communicative competence (ICC). In China,…

  5. 78 FR 19195 - RH International, LLC, 2531 West Maryland Avenue, Tampa, FL 33629, Respondent, Mohammad Reza (a/k...

    Science.gov (United States)

    2013-03-29

    ... Bureau of Industry and Security RH International, LLC, 2531 West Maryland Avenue, Tampa, FL 33629...; Order Denying Export Privileges A. Denial of Export Privileges of RH International, LLC On October 18, 2012, in the U.S. District Court, Middle District of Florida Tampa Division, RH International, LLC...

  6. Characterization of an Alginate Lyase, FlAlyA, from Flavobacterium sp. Strain UMI-01 and Its Expression in Escherichia coli

    Science.gov (United States)

    Inoue, Akira; Takadono, Kohei; Nishiyama, Ryuji; Tajima, Kenji; Kobayashi, Takanori; Ojima, Takao

    2014-01-01

    A major alginate lyase, FlAlyA, was purified from the periplasmic fraction of an alginate-assimilating bacterium, Flavobacterium sp. strain UMI-01. FlAlyA showed a single band of ~30 kDa on SDS-PAGE and exhibited the optimal temperature and pH at 55 °C and pH 7.7, respectively. Analyses for substrate preference and reaction products indicated that FlAlyA was an endolytic poly(mannuronate) lyase (EC 4.2.2.3). A gene fragment encoding the amino-acid sequence of 288 residues for FlAlyA was amplified by inverse PCR. The N-terminal region of 21 residues except for the initiation Met in the deduced sequence was predicted as the signal peptide and the following region of six residues was regarded as propeptide, while the C-terminal region of 260 residues was regarded as the polysaccharide-lyase-family-7-type catalytic domain. The entire coding region for FlAlyA was subjected to the pCold I—Escherichia coli BL21(DE3) expression system and ~eight times higher yield of recombinant FlAlyA (recFlAlyA) than that of native FlAlyA was achieved. The recFlAlyA recovered in the periplasmic fraction of E. coli had lost the signal peptide region along with the N-terminal 3 residues of propeptide region. This suggested that the signal peptide of FlAlyA could function in part in E. coli. PMID:25153766

  7. Characterization of an Alginate Lyase, FlAlyA, from Flavobacterium sp. Strain UMI-01 and Its Expression in Escherichia coli

    Directory of Open Access Journals (Sweden)

    Akira Inoue

    2014-08-01

    Full Text Available A major alginate lyase, FlAlyA, was purified from the periplasmic fraction of an alginate-assimilating bacterium, Flavobacterium sp. strain UMI-01. FlAlyA showed a single band of ~30 kDa on SDS-PAGE and exhibited the optimal temperature and pH at 55 °C and pH 7.7, respectively. Analyses for substrate preference and reaction products indicated that FlAlyA was an endolytic poly(mannuronate lyase (EC 4.2.2.3. A gene fragment encoding the amino-acid sequence of 288 residues for FlAlyA was amplified by inverse PCR. The N-terminal region of 21 residues except for the initiation Met in the deduced sequence was predicted as the signal peptide and the following region of six residues was regarded as propeptide, while the C-terminal region of 260 residues was regarded as the polysaccharide-lyase-family-7-type catalytic domain. The entire coding region for FlAlyA was subjected to the pCold I—Escherichia coli BL21(DE3 expression system and ~eight times higher yield of recombinant FlAlyA (recFlAlyA than that of native FlAlyA was achieved. The recFlAlyA recovered in the periplasmic fraction of E. coli had lost the signal peptide region along with the N-terminal 3 residues of propeptide region. This suggested that the signal peptide of FlAlyA could function in part in E. coli.

  8. A flânerie hipermoderna em uma urbis simulada: os novos vagabundos iluminados digitais

    Directory of Open Access Journals (Sweden)

    Ana Paula Perissé

    2014-04-01

    Full Text Available O objetivo deste trabalho é discutir a nova reconfiguração de uma prática social moderna, a avatar-flânerie, que emerge em função do surgimento de um novo espaço urbano e virtual, que se configura para além da emergência das cidades digitais, cibercidades, cidades ciborgues (LEMOS, 2003 e suas implicações com a instância do real, assim como o seu impacto nas subjetividades contemporâneas. A idéia de metacibercidades expressa com maestria exatamente o que está em questão: uma mudança, uma sucessão, que se coloca no além daquilo que ainda está em análise: o surgimento das cibercidades em concomitância com a emergência de novos espaços urbanos-arquitetônicos-virtuais simulados, construídos e reconfigurados cotidianamente por mais de 2 milhões de pessoas, jogadores do MMPORPG ( massive multiplayer on line role playing game -  Second Life.Para tanto, discutiremos rapidamente o conceito de cibercidade, a partir de uma rápida historiografia da idéia de cidade moderna, contextualizando-a como um artifício técnico onde novas redes de sociabilidade entram em cena a partir do surgimento das novas tecnologias móveis.Num segundo momento, migramos para o ambiente da nova urbis virtual, entendida aqui como uma extensão–protética-tecnológica das cidades digitais, onde novos atores sociais – netizens- exteriorizam neste novo espaço uma possibilidade-hipótese de uma nova flânerie criativa na figura de um  sujeito-jogador-avatar.  À luz das idéias de Walter Benjamin em sua obra “Passagens”, construiremos uma análise das novíssimas práticas hipermodernas de percepção/observação flaneuse e possíveis respectivas alterações dos espaços urbanos virtuais no limite da experiência orgânica/digital, da vida vivida influenciada pela experiência do viver no ciber design urbano.

  9. Comparison of Chloroflexus aurantiacus strain J-10-fl proteomes of cells grown chemoheterotrophically and photoheterotrophically

    Energy Technology Data Exchange (ETDEWEB)

    Cao, Li; Bryant, Donald A.; Schepmoes, Athena A.; Vogl, Kajetan; Smith, Richard D.; Lipton, Mary S.; Callister, Stephen J.

    2012-01-17

    Chloroflexus aurantiacus J-10-fl is a thermophilic green bacterium, a filamentous anoxygenic phototroph, and the model organism of the phylum Chloroflexi. We applied high-throughput, liquid chromatography-mass spectrometry in a global quantitative proteomics investigation of C. aurantiacus cells grown under oxic (chemoorganoheterotrophically) and anoxic (photoorganoheterotrophically) redox states. Our global analysis identified 13,524 high-confidence peptides that matched to 1,286 annotated proteins, 242 of which were either uniquely identified or significantly increased in abundance under anoxic culture conditions. Fifty-three of the 242 proteins are previously characterized photosynthesis-related proteins, including chlorosome proteins, proteins involved in the bacteriochlorophyll biosynthesis, 3-hydroxypropionate (3-OHP) CO2 fixation pathway, and components of electron transport chains. The remaining 190 proteins have not previously been reported. Of these, five proteins were found to be encoded by genes from a novel operon and observed only in photoheterotrophically grown cells. These proteins candidates may prove useful in further deciphering the phototrophic physiology of C. aurantiacus and other filamentous anoxygenic phototrophs.

  10. Flüchtige Spuren in arabischen Quellen: Writing the Feminine Women in Arabic Sources

    Directory of Open Access Journals (Sweden)

    Barbara Winckler

    2002-11-01

    Full Text Available Writing the Feminine versammelt 13 Beiträge zur Frauengeschichte der arabischen Welt, insbesondere Andalusiens und des Maghreb der klassischen Zeit. Eine Vielzahl von Primärquellen werden daraufhin analysiert, welche Aussagen zu Handlungsspielräumen von Frauen – und ihren Grenzen – sich aus ihnen herauslesen lassen. Die unterschiedlichen Textsorten erhellen sich zum Teil auf überraschende Weise. Mag der Ertrag auch zunächst gering und die weiblichen Spuren flüchtig erscheinen, so stellt der Band doch einen wichtigen ersten Schritt dar, dem weitere folgen sollten.The thirteen essays featured in this anthology deal with women’s history in the Arabic world, particularly Andalusia and classical Maghreb. The authors examine numerous primary sources for their ideas about women’s spaces (as well as their limits. Occasionally the different kinds of texts under investigation turn out to be full of surprises While the results may seem meagre at first, the anthology nonetheless represents a first step in an important direction.

  11. Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator.

    Science.gov (United States)

    Tour, Oded; Adams, Stephen R; Kerr, Rex A; Meijer, Rene M; Sejnowski, Terrence J; Tsien, Richard W; Tsien, Roger Y

    2007-07-01

    Intracellular Ca(2+) regulates numerous proteins and cellular functions and can vary substantially over submicron and submillisecond scales, so precisely localized fast detection is desirable. We have created a approximately 1-kDa biarsenical Ca(2+) indicator, called Calcium Green FlAsH (CaGF, 1), to probe [Ca(2+)] surrounding genetically targeted proteins. CaGF attached to a tetracysteine motif becomes ten-fold more fluorescent upon binding Ca(2+), with a K(d) of approximately 100 microM, <1-ms kinetics and good Mg(2+) rejection. In HeLa cells expressing tetracysteine-tagged connexin 43, CaGF labels gap junctions and reports Ca(2+) waves after injury. Total internal reflection microscopy of tetracysteine-tagged, CaGF-labeled alpha(1C) L-type calcium channels shows fast-rising depolarization-evoked Ca(2+) transients, whose lateral nonuniformity suggests that the probability of channel opening varies greatly over micron dimensions. With moderate Ca(2+) buffering, these transients decay surprisingly slowly, probably because most of the CaGF signal comes from closed channels feeling Ca(2+) from a tiny minority of clustered open channels. With high Ca(2+) buffering, CaGF signals decay as rapidly as the calcium currents, as expected for submicron Ca(2+) domains immediately surrounding active channels. Thus CaGF can report highly localized, rapid [Ca(2+)] dynamics.

  12. Media Optimization for Production of Saccharomyces cerevisiae FL-1 by Response Surface Method%响应面法优化Saccharomyces cerevisiae FL-1培养基

    Institute of Scientific and Technical Information of China (English)

    王亚军; 姚善泾; 吴天星

    2003-01-01

    以筛选得到的Saccharomyces cerevisiae (面包酵母) FL-1菌株作为研究对象,考察了培养基中碳、氮源和酵母浸出物对该酵母生物量的影响,通过响应面法建立了生物量和蔗糖、硫酸铵及酵母浸出物浓度之间的关系,实现培养基的优化.摇瓶发酵结果表明,由蔗糖、硫酸铵和酵母浸出物为主要成分的培养基能满足S. cerevisiae FL-1生长繁殖对营养物质的需求,拟合得到的模型较好地符合实际,在考察范围内,酵母浸出物对生物量收率影响程度最高,蔗糖次之,硫酸铵最弱.最后,次氯酸钠氧化S. cerevisiae FL-1的自溶体可制备目标产物(1→3)-β-D-葡聚糖.

  13. Descriptive Analysis of Medication Administration During Inpatient Cardiopulmonary Arrest Resuscitation (from the Mayo Registry for Telemetry Efficacy in Arrest Study).

    Science.gov (United States)

    Snipelisky, David; Ray, Jordan; Matcha, Gautam; Roy, Archana; Dumitrascu, Adrian; Harris, Dana; Bosworth, Veronica; Clark, Brooke; Thomas, Colleen S; Heckman, Michael G; Vadeboncoeur, Tyler; Kusumoto, Fred; Burton, M Caroline

    2016-05-15

    Advanced cardiovascular life support guidelines exist, yet there are variations in clinical practice. Our study aims to describe the utilization of medications during resuscitation from in-hospital cardiopulmonary arrest. A retrospective review of patients who suffered a cardiopulmonary arrest from May 2008 to June 2014 was performed. Clinical and resuscitation data, including timing and dose of medications used, were extracted from the electronic medical record and comparisons made. A total of 94 patients were included in the study. Patients were divided into different groups based on the medication combination used during resuscitation: (1) epinephrine; (2) epinephrine and bicarbonate; (3) epinephrine, bicarbonate, and calcium; (4) epinephrine, bicarbonate, and epinephrine drip; and (5) epinephrine, bicarbonate, calcium, and epinephrine drip. No difference in baseline demographics or clinical data was present, apart from history of dementia and the use of calcium channel blockers. The number of medications given was correlated with resuscitation duration (Spearman's rank correlation = 0.50, p <0.001). The proportion of patients who died during the arrest was 12.5% in those who received epinephrine alone, 30.0% in those who received only epinephrine and bicarbonate, and 46.7% to 57.9% in the remaining groups. Patients receiving only epinephrine had shorter resuscitation durations compared to that of the other groups (p <0.001) and improved survival (p = 0.003). In conclusion, providers frequently use nonguideline medications in resuscitation efforts for in-hospital cardiopulmonary arrests. Increased duration and mortality rates were found in those resuscitations compared with epinephrine alone, likely due to the longer resuscitation duration in the former groups. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Expanding the thermodynamical potential and the analysis of the possible phase diagram of deconfinement in FL model

    CERN Document Server

    Shu, Song

    2011-01-01

    The deconfinement phase transition is studied in the FL model at finite temperature and chemical potential. At MFT approximation, the phase transition can only be the first order in the whole $\\mu-T$ phase plane. By a Landau expansion we further study the phase transition order and the possible phase diagram of deconfinement. We discuss the possibilities of second order phase transitions in FL model. By our analysis the cubic term in the Landau expansion could be cancelled by the high order fluctuations. By an ansatz of the Landau parameters, we obtain the possible phase diagram with both first and second order phase transition including the tricritical point which is similar to that of the chiral phase transition.

  15. MYB-FL controls gain and loss of floral UV absorbance, a key trait affecting pollinator preference and reproductive isolation.

    Science.gov (United States)

    Sheehan, Hester; Moser, Michel; Klahre, Ulrich; Esfeld, Korinna; Dell'Olivo, Alexandre; Mandel, Therese; Metzger, Sabine; Vandenbussche, Michiel; Freitas, Loreta; Kuhlemeier, Cris

    2016-02-01

    Adaptations to new pollinators involve multiple floral traits, each requiring coordinated changes in multiple genes. Despite this genetic complexity, shifts in pollination syndromes have happened frequently during angiosperm evolution. Here we study the genetic basis of floral UV absorbance, a key trait for attracting nocturnal pollinators. In Petunia, mutations in a single gene, MYB-FL, explain two transitions in UV absorbance. A gain of UV absorbance in the transition from bee to moth pollination was determined by a cis-regulatory mutation, whereas a frameshift mutation caused subsequent loss of UV absorbance during the transition from moth to hummingbird pollination. The functional differences in MYB-FL provide insight into the process of speciation and clarify phylogenetic relationships between nascent species.

  16. Expanding the thermodynamical potential and analysis of the possible phase diagram of deconfinement in the FL model

    Institute of Scientific and Technical Information of China (English)

    SHU Song; LI Jia-Rong

    2012-01-01

    Deconfinement phase transition is studied in the FL model at finite temperature and chemical potential.At MFT approximation,phase transition can only be first order in the whole μ-T phase plane.Using a Landau expansion,we further study the phase transition order and the possible phase diagram of deconfinement. We discuss the possibilities of second order phase transitions in the FL model. From our analysis,if the cubic term in the Landau expansion could be cancelled by the higher order fluctuations,second order phase transition may occur.By an ansatz of the Landau parameters,we obtain a possible phase diagram with both the first and second order phase transitions,including the tri-critical point which is similar to that of the chiral phase transition.

  17. Proof for part of the Sttla flow experimental conclusion and the improvement of Flügel formula

    Institute of Scientific and Technical Information of China (English)

    张春发; 崔映红; 杨文滨; 张德成; 宋之平

    2002-01-01

    Based on steam turbine's basic working principle,we draw the conclusion that at the critical state,critical pressure is proportional to its critical flow and square root of initial temperature.Part of the Sttla flow experimental curve is verified theoretically and an improved Flügel formula with a higher accuracy is proposed.As a result,not only the calculation is simplified,but also the theory of steam turbine's varying operation conditions is enriched.

  18. Final Environmental Assessment: For Immediate Storm Surge Protection for Santa Rosa Island Facilities, Eglin Air Force Base, FL

    Science.gov (United States)

    2006-06-01

    allowable atmospheric concentration that may occur and still protect public health and welfare with a reasonable margin of safety. The NAAQS...federal agencies to make every effort to reduce the risk of flood loss, minimize the impact of floods on human health, safety, and welfare , and preserve...Protection for Santa Rosa Island Facilities, Eglin Air Force Base, FL Davis et al., 2000 Davis, R. W., W. E. Evans, B. Würsig (eds), 2000. Cetaceans

  19. Can lexical errors inform about word class acquisition in FL?: evidence from greek learners of Spanish as a foreign language

    OpenAIRE

    Kiriaki Palapanidi; María Pilar Agustín Llach

    2014-01-01

    This research examines the order of acquisition of words of four different classes: verbs, nouns, adjectives, and adverbs in three different levels of proficiency in the FL. We apply the procedure of Error Analysis to a corpus of written compositions and analyze the interlingual and intralingual lexical errors (formal and semantic) of the Greek students of Spanish as a Foreign Language (SFL). Our results have shown us that there is relationship between the type of word and the production of l...

  20. Free antibiotic and vaccination programmes in community pharmacies of Miami-Dade County, FL, USA.

    Science.gov (United States)

    Gauthier, Timothy P; Suda, Katie J; Mathur, Sunil Kumar; Harriman, David; Pham, Jenny; Aragon, Laura; Abbo, Lilian M; Hooton, Thomas M

    2015-02-01

    Some community pharmacies provide prescribed oral antibiotics for free to incentivize customers. This can influence prescribing practices and may increase inappropriate antibiotic use. Thus, pleas to incorporate education and/or vaccinations into these initiatives have been made by the CDC and IDSA. This study aims to investigate the prevalence and characteristics of free antibiotic programmes (FAPs) and free vaccination programmes (FVPs) offered by community pharmacies within a major US county. Additionally, we evaluated the association between FAP location and proximate socioeconomic status. A telephone survey was administered to all community pharmacies in operation and located in Miami-Dade County, FL, USA (n=668). Population characteristics at the five-digit ZIP code level were acquired from the 2010 US Census and American Communities Survey. An independent t-test, Kruskal-Wallis and logistic regression were used for statistical analysis. A total of 660 community pharmacies agreed to the telephone survey (response rate=98.8%). FAPs were present in 6.8% of pharmacies (n=45) and none incorporated an educational component targeted at patients or prescribers. Ciprofloxacin and amoxicillin were offered by all FAPs and 84.4% provided up to a 14 day supply (n=38). Thirty-four of 72 ZIP codes had an FAP and those with a programme had larger populations and higher incomes (P≤0.05). Family income≥$75,000 (P=0.0002) was an independent predictor of FAP availability. None of the surveyed pharmacies offered a FVP. Frequently provided by chain pharmacies and located in areas of higher income, FAPs within Miami-Dade County offer broad-spectrum antibiotics for long durations without additional education to patients or prescribers. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  1. Magnetic Fabrics and their Application to Basal Crevasse Fills, Flàajökull, Iceland

    Science.gov (United States)

    Jacobson, W. R., Jr.; Hooyer, T.

    2014-12-01

    Long, linear features consisting of sediment and ice, approximately 100 m long and 20 cm wide, run transverse to the margin of Flàajökull, an outlet glacier of Vatnajökull Ice Cap. These features, interpreted as basal crevasse fills, are thought to have formed by debris and water injected into a void under pure tension or a combination of tension and shear in response to an ice pressure drop at the bed. The debris content of these basal crevasse fills are between 5 to 10% by volume. The formation of these basal crevasse fills is uncertain, because direct observation is difficult. To study these basal crevasse fills, we used the orientation of magnetic grains using anisotropy of magnetic susceptibility (AMS) to guide us in understanding their kinematics. The AMS technique is superior over other fabric methods because a three-dimensional susceptibility ellipsoid is used to determine strain. We sampled two basal crevasse fills and obtained 86 ice core samples for AMS analyses. We also cut nine blocks of ice to determine the magnetic mineralogy, grain size of the magnetic carrier and c-axis orientation of the ice. The AMS results demonstrate that at one fill, the fabric was most likely formed by a combination of pure shear and simple shear. At the second site the AMS results were not well clustered possibly due to insufficient strain. Hysteresis and high temperature susceptibility tests indicate a magnetite carrier that was silt-sized or smaller. Thin sections used to evaluate c-axis fabrics display several multi-maximums that suggested that the fabric developed through recrystallization during deformation. It is inferred that grain scale processes reveal deformation by grain-boundary migration and grain nucleation. Magnetic particles appear to have behaved as passive markers following the March model (1932). Given this data set, we argue that the crevasse fills were formed by multiple processes including injection of turbid waters followed by in situ-freezing and

  2. Cold Sore

    Science.gov (United States)

    ... fluid-filled blisters typically break out along the border where the outside edge of the lips meets ... MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo ...

  3. Postherpetic Neuralgia

    Science.gov (United States)

    ... possibly touching it in places to determine the borders of the affected area. In most cases, no ... MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo ...

  4. Breast Lumps

    Science.gov (United States)

    ... You might notice: A distinct lump with definite borders A firm, hard area within your breast A ... MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo ...

  5. Livedo Reticularis: When Is It a Concern?

    Science.gov (United States)

    ... in sort of a netlike pattern with distinct borders. Sometimes livedo reticularis is simply the result of ... MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo ...

  6. Mayo Registry for Telemetry Efficacy in Arrest (MR TEA) study: An analysis of code status change following cardiopulmonary arrest.

    Science.gov (United States)

    Snipelisky, David; Ray, Jordan; Matcha, Gautam; Roy, Archana; Chirila, Razvan; Maniaci, Michael; Bosworth, Veronica; Whitman, Anastasia; Lewis, Patricia; Vadeboncoeur, Tyler; Kusumoto, Fred; Burton, M Caroline

    2015-07-01

    Code status discussions are important during a hospitalization, yet variation in its practice exists. No data have assessed the likelihood of patients to change code status following a cardiopulmonary arrest. A retrospective review of all patients that experienced a cardiopulmonary arrest between May 1, 2008 and June 30, 2014 at an academic medical center was performed. The proportion of code status modifications to do not resuscitate (DNR) from full code was assessed. Baseline clinical characteristics, resuscitation factors, and 24-h post-resuscitation, hospital, and overall survival rates were compared between the two subsets. A total of 157 patients survived the index event and were included. One hundred and fifteen (73.2%) patients did not have a change in code status following the index event, while 42 (26.8%) changed code status to DNR. Clinical characteristics were similar between subsets, although patients in the change to DNR subset were older (average age 67.7 years) compared to the full code subset (average age 59.2 years; p = 0.005). Patients in the DNR subset had longer overall resuscitation efforts with less attempts at defibrillation. Compared to the DNR subset, patients that remained full code demonstrated higher 24-h post-resuscitation (n = 108, 93.9% versus n = 32, 76.2%; p = 0.001) and hospital (n = 50, 43.5% versus n = 6, 14.3%; p = 0.001) survival rates. Patients in the DNR subset were more likely to have neurologic deficits on discharge and shorter overall survival. Patient code status wishes do tend to change during critical periods within a hospitalization, adding emphasis for continued code status evaluation. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. Hoy hace: la erupción del Rincón de la Vieja el 8 de mayo de 1991

    Directory of Open Access Journals (Sweden)

    Soto Bonilla, Gerardo

    2005-08-01

    Full Text Available Uno de los eventos volcánicos importantes del siglo XX en Costa Rica fue el ocurrido el 8 de mayo del año 1991 en el Volcán Rincón de la Vieja. A continuación, se muestra la información recopilada en la serie Hoy hace. concerniente a la emergencia suscitada en esa ocasión. Se incluye una relación de las principales observaciones reportadas con respecto al Volcán desde el año 1765 hasta el año 1998. El documento explica el mecanismo de la erupción principal y enlista las actividades posteriores que se dieron One of the important volcanic events of the 20th Century in Costa Rica was the one of May 8, 1991 at the Rincón de la Vieja Volcano. Following, it shows the information collected in the series Today in History (Hoy hace related to the emergency generated at that moment. It includes a relation to the main observations reported in regards to the Volcano from the year 1765 to the year 1998. The document explains the mechanism of the main eruption and lists the posterior activities

  8. El asedio de Manila (mayo-agosto 1898. «Diario de los sucesos ocurridos durante la guerra de España con Estados Unidos, 1898»

    Directory of Open Access Journals (Sweden)

    Togores Sánchez, Luis E.

    1998-08-01

    Full Text Available There are two landmarks in the loss of Philippines in 1898: the Cavite naval battle and the subsequent siege of Manila. Between May and August 1898 the Tagalo independentist forces under Aguinaldo, and the Northamerican soldiers under Commodore Dewey and General Merrit, laid siege to and took over the capital city of the Colony after a long and hard siege, full of struggles. A Jesuit's personal diary found in the Rome archives provides a day-by-day chronicle of the siege. By contrasting this Information with other existing documentation it has been possible to reconstruct one of the historical keys to the understanding of Spain's defeat in the Pacific.

    La pérdida de Filipinas en 1898 tiene dos hitos, la batalla naval de Cavite y el subsiguiente asedio de Manila. Entre mayo y agosto de 1898 las fuerzas independentistas tagalas de Aguinaldo y los soldados norteamericanos del comodoro Dewey y el general Merrit sitiaron la capital de la colonia para finalmente rendirla el 13 de agosto tras un duro y largo asedio repleto de combates. El diario de un jesuita encontrado en los archivos de Roma, el cual narra día a día aquellos sucesos, nos permite reconstruir —contrastándolo con otra documentación existente— una de las claves históricas para comprender la derrota de España ante los Estados Unidos en el Pacífico.

  9. Las primeras declaraciones de los profesionales de la salud del Hospital de Campo de Mayo. Una aproximación a las actitudes sociales en la última Dictadura

    Directory of Open Access Journals (Sweden)

    Clara Sarsale

    2016-08-01

    Full Text Available En los primeros meses del gobierno de Raúl Alfonsín, en 1984, la Comisión Nacional sobre la Desaparición de Personas comenzó a recibir testimonios de todo aquel que tuviera información sobre lo acontecido en los años de dictadura. Entre los declarantes se encontraron familiares de desaparecidos, sobrevivientes, entre otros testigos menos usuales. Allí residirá el foco de este trabajo: en el testimonio de algunos de los profesionales de la salud del Hospital Militar de Campo de Mayo frente a la CONADEP. Estos profesionales, asistieron los partos de mujeres que se encontraban secuestradas por la dictadura. Como se verá en el artículo, ubicados en el corazón del sistema represivo, estos profesionales tuvieron diversas respuestas frente a lo que estaba ocurriendo. Su estudio, permite abrir nuevas preguntas sobre las actitudes sociales en dictadura.

  10. La identidad en la encrucijada: la comunidad galesa del Chubut y las conmemoraciones del Centenario y Bicentenario de la Revolución de Mayo

    Directory of Open Access Journals (Sweden)

    Geraldine Lublin

    2013-12-01

    Full Text Available El presente artículo se propone rastrear a grandes rasgos la relación ―especial‖ entre el estado nacional argentino y, a partir de 1958, la provincia de Chubut por una parte y los colonos galeses que se establecieron en Chubut desde 1865 y sus descendientes por otra, a través del análisis de la posición de la colectividad galesa del Chubut en dos momentos históricos destacados: el Centenario y el Bicentenario de la Revolución de Mayo (1810. Al corresponderse el perfil de los galeses con la idea de poblaciones "civilizadas" que las autoridades pretendían impulsar en desmedro de los legítimos pobladores originales, estas políticas dieron lugar a una fuerte identificación histórica de la Provincia de Chubut con la llamada "gesta galesa". Se generó asimismo una peculiar dinámica triangular de las relaciones estatales, cuya evolución a través del tiempo ha desembocado en la actual promoción de la identidad chubutense como el resultado de la fusión de las culturas de los tehuelches originarios y los colonos galeses.

  11. Hydatidiform mole clinical and pathological characteristics

    OpenAIRE

    Pacheco D., José; Instituto de Patología, UNMSM; Instituto de Medicina Legal; Alegre, Jaime; Hospital Nacional Dos de Mayo, Lima, Perú; Paniagua, Gissela; Instituto de Patología de la UNMSM

    2013-01-01

    Objective: To determine clinical and pathological findings in hydatidiform mole. Design: Descriptive retrospective study. Material and methods: All cases de molar pregnancy attended at Dos de Mayo National Hospital (HNDM) between 1998 and 2001 were reviewed. Results: Twenty-four cases of hydatidiform mole were attended; mean age was 26,4 years ± 6,4 and gestational age 13,1 weeks ± 3,3. Past history only showed 1 and 3 cases of hyperemesis gravidarum and previous abortions, respectively; 18 p...

  12. Lesão do bíceps distal: avaliação funcional e dinamometria digital da sua reconstrução pela técnica da minidupla via de mayo Isokinetic and functional: evaluation of the distal biceps reconstruction by using the mayo technique

    Directory of Open Access Journals (Sweden)

    José Carlos Garcia Júnior

    2012-10-01

    Full Text Available OBJETIVO: Avaliar o resultado funcional de pacientes com lesão do bíceps distal, operados pela técnica da minidupla via de Mayo, com seguimento mínimo de seis meses pós-cirurgia através de dinamometria digital isocinética, goniometria e escores subjetivos a fim de estabelecer padrões objetivos e subjetivos de melhora e discutir a efetividade do procedimento. MÉTODOS: Foram avaliados nove pacientes submetidos à cirurgia para tratamento de lesão do bíceps distal através de dinamometria digital com Cybex® utilizando velocidade angular de 30°/s, cinco repetições e 120°/s, 15 repetições, comparando com o lado não lesado. Foram utilizados também DASH (Disabilities of the Arm, Shoulder and Hand, MayoElbow Score e goniometria convencional. RESULTADOS: A dinamometria digital mostrou que à velocidade angular de 30°/s com cinco repetições a flexão apresentou déficit médio de 9,6% e a supinação déficit médio de -28,97%. Com velocidade angular de 120°/s com 15 repetições, a flexão teve déficit médio de 4,43%; a supinação de -24,1%. CONCLUSÕES: A Perda de flexão segue o padrão já demonstrado na literatura; entretanto, em nossa série houve ganho de força para supinação, possivelmente devido ao protocolo rígido de reabilitação. A técnica empregada neste estudo mostrou-se segura, de baixo custo e com poucas complicações, apresentando bons resultados funcionais.OBJECTIVE: To evaluate the functional outcome among patients with distal biceps injuries who were operated using the Mayo mini-double route technique, with a minimum follow-up of six months after surgery, through digital isokinetic dynamometry, goniometry and subjective scores in order to establish objective and subjective improvement patterns and discuss the effectiveness of the procedure. METHODS: Nine patients who underwent surgery to treat distal biceps injury were evaluated by means of Cybex digital dynamometry using an angular velocity of 30

  13. Agresión infantil como problema social en Costa Rica, desde enero de 2005 hasta mayo de 2006 Child Abuse as a Social Problem in Costa Rica, from January 2005 to May 2006

    Directory of Open Access Journals (Sweden)

    Carlos Abarca Campos

    2006-09-01

    Full Text Available La agresión infantil es un problema social que ha persistido a lo largo de la historia. La problemática abarca lesiones tanto a nivel físico como psicológico. La clínica, en la mayor parte de las veces, es el eje principal en el diagnóstico acertado y el posterior manejo. En este trabajo se analizaron 192 casos de agresión infantil durante el periodo comprendido entre enero de 2005 y mayo de 2006 y se presentan sus resultados donde la mayoría de los maltratos infantiles incluye abuso sexual, no es común la atención médica luego de la agresión, las víctimas consultan mucho tiempo después y se presentan más casos de maltrato infantil en el mes de Diciembre lo cual podemos asociar con las conductas del mes que suelen ser más irresponsables (fiestas, alcohol, etc.. Es importante que el médico tenga claro los signos de abuso sexual y sus repercusiones tanto físicas como psicológicas ya que es el tipo de agresión más frecuente y muchas veces puede pasar desapercibida.Child abuse is an issue which has persisted through history. This problem includes not only physical, but psychological damage. Clinical report, most of the times, is the principal axis in the correct diagnosis and the posterior treatment. In this study, 192 cases of child abuse were analyzed between January 2005 and May 2006, and the results presented most of the cases include child molesting, occasional medical attention after the assault, the victims receive medical attention long time after the assault, and most of the cases occur during December, which can be associated with irresponsible behavior (alcohol, parties, etc.. It is very important that the physician is very clear about the signs of sexual abuse and its physical and psychological consequences, since it is the most common type of aggression and in many cases can be unnoticed.

  14. Invocación de motivos religiosos en propaganda política Análisis de la resolución n° 3281-E1-2010 del 3 de mayo de 2010

    Directory of Open Access Journals (Sweden)

    Gustavo Román Jacobo

    2011-01-01

    Full Text Available Describe los aspectos esenciales de la resolución del Tribunal Supremo de Elecciones de Costa Rica, número 3281-E1-2010 del 3 de mayo de 2010, en la cual se resuelve el tema sobre la invocación de motivos religiosos en la propagranda política. A la vez explica la lógica básica que lo sustenta conceptualmente.

  15. Avaliação da concentração de flúor em águas minerais comercializadas no Brasil

    Directory of Open Access Journals (Sweden)

    Rita S. Villena

    1996-12-01

    Full Text Available A utilização de flúor sistêmico deve ser controlada em termos de risco/benefício, pois enquanto a subdosagem não trouxer benefício anticárie, a sobredosagem estará associada com fluorose dental. Assim, uma das preocupações é o consumo de águas minerais, o qual tem aumentado nos últimos anos. Deste modo, foi realizado estudo com o objetivo de analisar a concentração de flúor em águas minerais comercializadas no Brasil. Foram analisadas 104 marcas comerciais, de diferentes regiões do País. Utilizou-se eletrodo específico Orion 96-09 e analisador de íons Orion EA 940, previamente calibrados com soluções padrões de flúor. Foram observadas concentrações de flúor variando de 0,0 a 4,4 ppm. Constataram-se: 1 Concentrações significativas de flúor não relatadas pelo produtor; 2 Concentrações de flúor sem significado preventivo anti-cárie, embora o produtor destaque na embalagem "Água Mineral Fluoretada"; 3 Concentrações de flúor capazes de provocar fluorose dental severa, embora o produtor não faça nenhuma referência que o mesmo existe. Conclui-se ser necessário um Sistema de Vigilância Sanitária para o controle de flúor nas águas minerais oferecidas à população brasileira, quer seja em termos de benefício como de risco.

  16. Biomarkers for Early Detection a nd Screening in Pancreatic Cancer Highlights from the “45 th ASCO Annual Meeting”. Orlando, FL, USA. May 29 - June 2, 2009

    Directory of Open Access Journals (Sweden)

    Christopher J Hoimes

    2009-07-01

    Full Text Available Pancreatic cancer is the second most frequent gastrointestinal malignancy with an unabated mortality that reflects the advanced stage of presentation. Detection of early disease through screening likely is the best way to meaningfully prolong survival. The development of biomarkers for screening holds enormous promise for increasing early detection and impacting mortality. Many biomarkers have been studied including the serum protein carbohydrate antigen 19-9, vascular endothelial growth factor, and nuclear factor kappa B, however, still no blood test or other fluid analysis reliably predicts patients with disease. The authors review abstracts from the 2009 annual meeting of the American Society of Clinical Oncology, Orlando, FL, U.S.A., that report evidence for early detection using a salivary biomarker array (#4630; a mucin epitope to PAM4 (#4613; a plasma nucleotide marker of hypoxia, miR-210 (#4624; and a cleavage product of complement pathway component C3b, iC3b (#4626. The meeting featured pancreatic cancer in over 100 research abstracts, of which, four are reviewed that focus on potential markers for early detection. When applied to a population of high risk patients, biomarkers of early pancreatic cancer could provide a minimally invasive way of identifying patients that require further evaluation using endoscopic tools. These molecular beacons may even be found to be sufficiently sensitive, specific, and cost effective to be applied to a broader population of patients.

  17. Drivers of phytoplankton dynamics in old Tampa Bay, FL (USA), a subestuary lagging in ecosystem recovery

    Science.gov (United States)

    Corcoran, Alina A.; Wolny, Jennifer; Leone, Erin; Ivey, James; Murasko, Susan

    2017-02-01

    In the past four decades, consistent and coordinated management actions led to the recovery of Tampa Bay, FL (USA) - an estuary that was declared dead in the 1970s. An exception to this success story is Old Tampa Bay, the northernmost subestuary of the system. Compared to the other bay segments, Old Tampa Bay is characterized by poorer water quality and spring and summer blooms of cyanobacteria, picoplankton, diatoms, and the saxitoxin-producing dinoflagellate Pyrodinium bahamense. Together, these blooms contribute to light attenuation and lagging recovery of seagrass beds. Yet, studies of phytoplankton dynamics within Old Tampa Bay have been limited - both in number and in their spatiotemporal resolution. In this study, we used field sampling and continuous monitoring to (1) characterize temporal and spatial variability in phytoplankton biomass and community composition and (2) identify key drivers of the different phytoplankton blooms in Old Tampa Bay. Overall, temporal variability in phytoplankton biomass (using chlorophyll a as a proxy) and community composition surpassed spatial variability of these parameters. We found a base community of small diatoms and flagellates, as well as certain dinoflagellates, that persisted year round in the system. Seasonally, freshwater runoff stimulated phytoplankton growth, specifically that of chlorophytes, cyanobacteria and other dinoflagellates - consistent with predictions based on ecological theory. On shorter time scales, salinity, visibility, and freshwater inflows were important predictors of phytoplankton biomass. With respect to P. bahamense, environmental drivers including salinity, temperature and dissolved nutrient concentrations explained ∼24% of the variability in cell abundance, indicating missing explanatory parameters in our study for this taxon, such as cyst density and location of cyst beds. Spatially, we found differences in community trajectories across north-south and west-east gradients, with the

  18. Suscetibilidade do capim-colonião e de cultivares de milho ao flúor

    Directory of Open Access Journals (Sweden)

    Rimena Ramos Domingues

    2011-01-01

    Full Text Available A emissão de fluoretos à atmosfera oriunda da produção de superfosfatos e de cerâmica tem causado preocupação pelo efeito tóxico às plantas, contudo são poucos os estudos desenvolvidos acerca do problema com espécie de interesse econômico agrícola. Desenvolveu-se o estudo para avaliar o efeito do flúor (F atmosférico em plantas de capim-colonião e de cultivares de milho, utilizando como referência espécies bioindicadoras do tipo sensível e tolerante. As plantas foram expostas à contaminação pelo F atmosférico por curtos períodos durante 32 dias em sistema de nebulização com 0,16 mol L-1 de ácido fluorídrico no ambiente interno de uma câmara (~0,20 mmol m-3 de F, havendo um controle não exposto, com quatro repetições. A exposição das plantas ao F causou aumento da concentração do elemento nas folhas até 60 mg kg-1 para o capim-colonião, e entre 100 mg kg-1 nas folhas novas e 170 mg kg-1 nas folhas velhas para quatro cultivares de milho, o que demonstrou o efeito cumulativo do elemento no ambiente. Sintomas visuais da toxicidade foram observados nas plantas e se caracterizaram pela ocorrência de cloroses e necroses na lâmina foliar. O capim-colonião é uma espécie bastante sensível ao poluente no ar. As cultivares de milho DKB 390 e Ômega 8315 também são mais sensíveis ao F quando comparadas às AG7088 e 2B707. Os teores de clorofila a nas plantas foram mais afetados pelo F em relação aos teores de clorofila b.

  19. Liberação de flúor de materiais restauradores Fluoride releasing of restorative materials

    Directory of Open Access Journals (Sweden)

    Adriana Silva de CARVALHO

    1998-10-01

    Full Text Available Atualmente no mercado odontológico existem diversos tipos de materiais restauradores que liberam flúor com o objetivo de diminuir ou eliminar as cáries recorrentes. Considerando-se a diferença de composição desses materiais, foi avaliada sua capacidade de liberação de flúor. Foram avaliados os materiais restauradores: Chelon-fil (ESPE, Vitremer (3M, Variglass (Dentsply, Dyract (Dentsply e Tetric (Vivadent. Confeccionaram-se seis amostras cilíndricas (área = 1,65 cm2 de cada material, as quais foram imersas individualmente em 2,0 ml de água deionizada, que foi trocada diariamente durante 15 dias. A liberação de flúor foi determinada após adição de volume igual de tampão TISAB II às soluções. Para a análise da concentração de flúor foi utilizado um eletrodo específico para flúor Orion 96-09, acoplado a um analisador de íons Orion EA-940. Todos os materiais seguiram o mesmo padrão de liberação de flúor. As maiores médias de flúor liberado dentro de cada material foram encontradas no 1º dia, decrescendo bruscamente no 2º e 3º dias, e a quantidade de flúor liberado apresentou um decréscimo com o passar dos dias até atingir um nível quase constante. A liberação média de flúor durante o período de avaliação (média e desvio padrão em µg F/cm2 foi: CHE = 7,62 ± 0,76A, VIT = 5,91 ± 0,79B, VAR = 2,72 ± 0,25C, DYR = 1,50 ± 0,17 D, TET = 0,136 ± 0,016 E. Médias seguidas por letras distintas diferem entre si ao nível de significância de 5% (Tukey. Os resultados mostraram que a composição dos materiais restauradores influencia de maneira significativa sua liberação de flúor.Nowadays there are several types of restorative materials with fluoride release properties. Thus, the purpose of this study was to analyze the fluoride release from the following restorative materials, considering their different compositions. The materials used were: Chelon Fil-ESPE (CHE, Vitremer-3M (VIT, Variglass

  20. “Barba Azul”: de Perrault a Wenceslao Fernández Flórez / “Bluebeard”: from Perrault to Wenceslao Fernández Flórez

    OpenAIRE

    Fermín Ezpeleta Aguilar

    2012-01-01

    Resumen: En este artículo se pone de manifiesto la amalgama de datos de historia real y de elementos míticos con los que se conforma literariamente el motivo literario de Barba Azul a lo largo del tiempo. Se deslindan, sobre todo, las dos versiones más importantes que hacen del motivo un cuento popular: la de Perrault y la de los hermanos Grimm, para analizar a continuación la reescritura que hace Wenceslao Fernández Flórez en su narración El secreto de Barba Azul (1923). Esta novela de form...

  1. Microbial synthesis of gold nanoparticles using the fungus Penicillium brevicompactum and their cytotoxic effects against mouse mayo blast cancer C 2 C 12 cells.

    Science.gov (United States)

    Mishra, Amrita; Tripathy, Suraj Kumar; Wahab, Rizwan; Jeong, Song-Hoon; Hwang, Inho; Yang, You-Bing; Kim, Young-Soon; Shin, Hyung-Shik; Yun, Soon-Il

    2011-11-01

    Microorganisms, their cell filtrates, and live biomass have been utilized for synthesizing various gold nanoparticles. The shape, size, stability as well as the purity of the bio synthesized nanoparticles become very essential for application purpose. In the present study, gold nanoparticles have been synthesized from the supernatant, live cell filtrate, and biomass of the fungus Penicillium brevicompactum. The fungus has been grown in potato dextrose broth which is also found to synthesize gold nanoparticles. The size of the particles has been investigated by Bio-TEM before purification, following purification and after storing the particles for 3 months under refrigerated condition. Different characterization techniques like X-ray diffraction, Fourier transform infrared spectroscopy, and UV-visible spectroscopy have been used for analysis of the particles. The effect of reaction parameters such as pH and concentration of gold salt have also been monitored to optimize the morphology and dispersity of the synthesized gold nanoparticles. A pH range of 5 to 8 has favored the synthesis process whereas increasing concentration of gold salt (beyond 2 mM) has resulted in the formation of bigger sized and aggregated nanoparticles. Additionally, the cytotoxic nature of prepared nanoparticles has been analyzed using mouse mayo blast cancer C(2)C(12) cells at different time intervals (24, 48, and 72 h) of incubation period. The cells are cultivated in Dulbecco's modified Eagle's medium supplemented with fetal bovine serum with antibiotics (streptopenicillin) at 37°C in a 5% humidified environment of CO(2). The medium has been replenished every other day, and the cells are subcultured after reaching the confluence. The viability of the cells is analyzed with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide method.

  2. Development of an Educational Game to Set Up Surgical Instruments on the Mayo Stand or Back Table: Applied Research in Production Technology.

    Science.gov (United States)

    Paim, Crislaine Pires Padilha; Goldmeier, Silvia

    2017-01-10

    Existing research suggests that digital games can be used effectively for educational purposes at any level of training. Perioperative nursing educators can use games to complement curricula, in guidance and staff development programs, to foster team collaboration, and to give support to critical thinking in nursing practice because it is a complex environment. To describe the process of developing an educational game to set up surgical instruments on the Mayo stand or back table as a resource to assist the instructor in surgical instrumentation training for students and nursing health professionals in continued education. The study was characterized by applied research in production technology. It included the phases of analysis and design, development, and evaluation. The objectives of the educational game were developed through Bloom's taxonomy. Parallel to the physical development of the educational game, a proposed model for the use of digital elements in educational game activities was applied to develop the game content. The development of the game called "Playing with Tweezers" was carried out in 3 phases and was evaluated by 15 participants, comprising students and professional experts in various areas of knowledge such as nursing, information technology, and education. An environment was created with an initial screen, menu buttons containing the rules of the game, and virtual tour modes for learning and assessment. The "digital" nursing student needs engagement, stimulation, reality, and entertainment, not just readings. "Playing with Tweezers" is an example of educational gaming as an innovative teaching strategy in nursing that encourages the strategy of involving the use of educational games to support theoretical or practical classroom teaching. Thus, the teacher does not work with only 1 type of teaching methodology, but with a combination of different methodologies. In addition, we cannot forget that skill training in an educational game does not

  3. Development of an Educational Game to Set Up Surgical Instruments on the Mayo Stand or Back Table: Applied Research in Production Technology

    Science.gov (United States)

    2017-01-01

    Background Existing research suggests that digital games can be used effectively for educational purposes at any level of training. Perioperative nursing educators can use games to complement curricula, in guidance and staff development programs, to foster team collaboration, and to give support to critical thinking in nursing practice because it is a complex environment. Objective To describe the process of developing an educational game to set up surgical instruments on the Mayo stand or back table as a resource to assist the instructor in surgical instrumentation training for students and nursing health professionals in continued education. Methods The study was characterized by applied research in production technology. It included the phases of analysis and design, development, and evaluation. The objectives of the educational game were developed through Bloom’s taxonomy. Parallel to the physical development of the educational game, a proposed model for the use of digital elements in educational game activities was applied to develop the game content. Results The development of the game called “Playing with Tweezers” was carried out in 3 phases and was evaluated by 15 participants, comprising students and professional experts in various areas of knowledge such as nursing, information technology, and education. An environment was created with an initial screen, menu buttons containing the rules of the game, and virtual tour modes for learning and assessment. Conclusions The “digital” nursing student needs engagement, stimulation, reality, and entertainment, not just readings. “Playing with Tweezers” is an example of educational gaming as an innovative teaching strategy in nursing that encourages the strategy of involving the use of educational games to support theoretical or practical classroom teaching. Thus, the teacher does not work with only 1 type of teaching methodology, but with a combination of different methodologies. In addition, we

  4. Burmese Refugee Transnationalism: What Is the Effect? Die Auswirkungen der transnationalen Verbindungen von birmanischen Flüchtlingen

    Directory of Open Access Journals (Sweden)

    Inge Brees

    2009-07-01

    Full Text Available Burmese refugees in Thailand maintain economic, social and political links with their country of origin, but these transnational activities are influenced by the politics and level of development of the country of origin and the host country. Through transnational activities, refugees can have a positive impact on the home country by contributing to peace-building and development or they can enhance conflict, as the discussion on community engagement and political transnationalism will illustrate. Clearly, the increased capacity and networks of the Burmese diaspora have bestowed it with a large (future potential to influence peace-building, development and conflict. Therefore, it is argued here that the various civil, political and military groups in exile should be included in the peace-building process initiated by international actors, next to stakeholders inside the country. Birmanische Flüchtlinge in Thailand haben ökonomische, soziale und politische Verbindungen zu ihrem Herkunftsland. Diese transnationalen Aktivitäten sind von der Politik und Entwicklungsstufe ihres Ursprungs- und ihres Gastlandes abhängig. Mit Hilfe transnationaler Aktivitäten können Flüchtlinge eine positive Wirkung auf ihr Heimatland haben, indem sie zur Friedenserhaltung und Entwicklung beitragen. Sie können jedoch auch den Konflikt weiter verschärfen, wie die Diskussion über Gemeinschaftsengagement und politischen Transnationalismus zeigt. Die wachsenden Fähigkeiten und Netzwerke der burmesischen Diaspora haben sie mit einem großen zukünftigen Potenzial ausgestattet, Friedensinitiativen, Entwicklungen und Konflikte zu beeinflussen. Der Artikel behauptet deshalb, dass die unterschiedlichen zivilen, politischen und militärischen Gruppen im Exil in einen Friedensprozess eingeschlossen werden sollen, der von internationalen Akteuren und nationalen Stakeholders im Land angestoßen werden sollte. Schlüsselwörter: Burma/ Myanmar, Flüchtlinge, Diaspora

  5. Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase FlK.

    Science.gov (United States)

    Weeks, Amy M; Keddie, Neil S; Wadoux, Rudy D P; O'Hagan, David; Chang, Michelle C Y

    2014-04-01

    The fluoroacetate-producing bacterium Streptomyces cattleya has evolved a fluoroacetyl-CoA thioesterase (FlK) that exhibits a remarkably high level of discrimination for its cognate substrate compared to the cellularly abundant analogue acetyl-CoA, which differs only by the absence of the fluorine substitution. A major determinant of FlK specificity derives from its ability to take advantage of the unique properties of fluorine to enhance the reaction rate, allowing fluorine discrimination under physiological conditions where both substrates are likely to be present at saturating concentrations. Using a combination of pH-rate profiles, pre-steady-state kinetic experiments, and Taft analysis of wild-type and mutant FlKs with a set of substrate analogues, we explore the role of fluorine in controlling the enzyme acylation and deacylation steps. Further analysis of chiral (R)- and (S)-[(2)H1]fluoroacetyl-CoA substrates demonstrates that a kinetic isotope effect (1.7 ± 0.2) is observed for only the (R)-(2)H1 isomer, indicating that deacylation requires recognition of the prochiral fluoromethyl group to position the α-carbon for proton abstraction. Taken together, the selectivity for the fluoroacetyl-CoA substrate appears to rely not only on the enhanced polarization provided by the electronegative fluorine substitution but also on molecular recognition of fluorine in both formation and breakdown of the acyl-enzyme intermediate to control active site reactivity. These studies provide insights into the basis of fluorine selectivity in a naturally occurring enzyme-substrate pair, with implications for drug design and the development of fluorine-selective biocatalysts.

  6. Meta-analysis comparing same-day versus delayedvitrectomy clinical outcomes for intravitreal retained lens fragments after age-relatedcataract surgery

    Directory of Open Access Journals (Sweden)

    Vanner EA

    2014-11-01

    Full Text Available Elizabeth A Vanner,1 Michael W Stewart21Department of Preventive Medicine, Pathology and Bioinformatics, Stony Brook University, Stony Brook, NY, USA; 2Department of Ophthalmology, Mayo Clinic College of Medicine, Jacksonville, FL, USAPurpose/design: We aimed to perform a systematic review and meta-analysis comparing the risk difference of clinical outcomes for same-day (SD vs delayed (DEL pars plana vitrectomy (PPV.Methods: We searched MEDLINE (English; January 1, 1985 to July 16, 2013 and article reference lists, for patients with crystalline retained lens fragments and discussion of SD-PPV vs DEL-PPV. For the meta-analysis, articles needed the number of patients receiving SD-PPV and DEL-PPV, and the number, in each group, who experienced one or more of the outcomes: not good visual acuity (VA (<20/40, bad VA (≤20/200, retinal detachment, increased intraocular pressure/glaucoma, intraocular infection/inflammation, cystoid macular edema, and corneal edema.Results: Of 304 articles identified, 23 provided data for the meta-analysis. Results were mixed, indicating 1 neither vitrectomy time produced better outcomes in all studies (not good VA risk difference =10.3% [positive numbers favored SD-PPV; negative numbers favored DEL-PPV], 95% confidence interval [CI] = [-0.4% to 21.0%], P=0.059; and bad VA risk difference =-0.3%, 95% CI = [-10.7% to 10.1%], P=0.953; 2 better outcomes with immediate SD-PPV compared with all DEL-PPV (not good VA risk difference =16.2%, 95% CI = [0.8% to 31.5%], P=0.039; and bad VA risk difference =8.5%; 95% CI = [0.8% to 16.2%], P=0.030; and 3 immediate SD-PPV and prompt DEL-PPV (3 to 14 days after cataract surgery had no significant differences and so may produce similar outcomes (not good VA risk differences range = [-19.9% to 6.5%], 95% CI = [-59.9% to 36.4%]; and bad VA risk differences range = [-6.9% to 7.4%], 95% CI = [-33.1% to 31.8%].Conclusion: Perhaps SD-PPV should be limited to facilities at which a

  7. Rayleigh-Ritz Vibrational Analysis of Multiwalled Carbon Nanotubes Based on the Nonlocal Flügge Shell Theory

    Directory of Open Access Journals (Sweden)

    H. Rouhi

    2015-01-01

    Full Text Available A nonlocal elastic shell model considering the small scale effects is developed to study the free vibrations of multiwalled carbon nanotubes subject to different types of boundary conditions. Based on the nonlocal elasticity and the Flügge shell theory, the governing equations are derived which include the interaction of van der Waals forces between adjacent and nonadjacent layers. To analytically solve the problem, the Rayleigh-Ritz method is employed. In the present analysis, different combinations of layerwise boundary conditions are taken into account. Some new intertube resonant frequencies and the associated noncoaxial vibrational modes are identified owing to incorporating circumferential modes into the shell model.

  8. Patient satisfaction and acceptability: a journey through an ambulatory gynaecology clinic in the West of Ireland

    LENUS (Irish Health Repository)

    Uzochukwu, I

    2016-06-01

    Ambulatory Gynaecology allows a “see-and-treat” approach to managing gynaecological conditions, providing a more streamlined, integrated care pathway than the traditional gynaecology clinic and inpatient care model. This study was designed to assess patient satisfaction and acceptability of Ambulatory Gynaecology services in Mayo University Hospital, Castlebar, Ireland. It also provided for feedback from patients as to how the service might be improved. \\r\

  9. Microvesicle Production After Trauma and its Clinical Impact on Veno-thrombolism

    Science.gov (United States)

    2012-10-01

    Department of Medicine, Mayo Clinic, Rochester Introduction: Trauma is an independent risk factor for venous thromboembolism (VTE; odds ratio ~12...all major trauma patients receive VTE chemoprophylaxis. This practice exposes those not at risk for thrombosis to potentially serious bleeding and...our military personnel. The patients who have polytrauma are at increased risk of developing either bleeding and/or a clot in their veins which

  10. “Barba Azul”: de Perrault a Wenceslao Fernández Flórez / “Bluebeard”: from Perrault to Wenceslao Fernández Flórez

    Directory of Open Access Journals (Sweden)

    Fermín Ezpeleta Aguilar

    2012-01-01

    Full Text Available Resumen: En este artículo se pone de manifiesto la amalgama de datos de historia real y de elementos míticos con los que se conforma literariamente el motivo literario de Barba Azul a lo largo del tiempo. Se deslindan, sobre todo, las dos versiones más importantes que hacen del motivo un cuento popular: la de Perrault y la de los hermanos Grimm, para analizar a continuación la reescritura que hace Wenceslao Fernández Flórez en su narración El secreto de Barba Azul (1923. Esta novela de formación tan representativa del autor se pone en conexión con el resto de su producción literaria y se comentan en ella aquellos aspectos temáticos y estructurales que inciden en la cuestión educativa, señalando intertextualidades con las versiones del cuento popular.Abstract: This article shows the historical data of real and mythical elements about Bluebeard motif over time. We identify in particular the two most important versions which make the topic a folktale: Perrault and Grimm Brothers, to discuss then the rewriting by Wenceslao Fernández Flórez, El secreto de Barba Azul (1923. This Bildungsroman connects strongly with the rest of his literature. We comment on the thematic and structural aspects that are closely related to education, noting intertextualities with versions of the folktale.

  11. A pilot study assessing social support among cancer patients enrolled on clinical trials: a comparison of younger versus older adults

    Directory of Open Access Journals (Sweden)

    Paul J Novotny

    2010-05-01

    Full Text Available Paul J Novotny1, Denise J Smith1, Lorna Guse2, Teresa A Rummans3, Lynn Hartmann4, Steven Alberts4, Richard Goldberg5, David Gregory6, Mary Johnson7, Jeff A Sloan11Health Sciences Research, Mayo Clinic, Rochester, MN, USA; 2Faculty of Nursing, University of Manitoba, Winnipeg, Manitoba, Canada; 3Psychiatry, Mayo Clinic, Rochester, MN, USA; 4Medical Oncology, Mayo Clinic, Rochester, MN, USA; 5Oncology Services, University of North Carolina, Chapel Hill, NC, USA; 6Faculty of Health Sciences Nursing, University of Lethbridge, Lethbridge, Alberta, Canada; 7Chaplain Services, Mayo Clinic, Rochester, MN, USAPurpose: This study tested the logistical feasibility of obtaining data on social support systems from cancer patients enrolled on clinical trials and compared the social support of older adults (age ≥65 and younger adults (<50 years of age with cancer.Methods: Patients had to be eligible for a phase II or phase III oncology clinical trial and enter the study prior to treatment. Patients filled out the Lubben Social Network Scale (LSNS at baseline. The Symptom Distress Scale (SDS and single-item overall quality of life (QOL Uniscale were assessed at baseline and weekly for 4 weeks.Results: There was no significant difference in overall mean Lubben social support levels by age. Older patients had more relatives they felt close to (85% versus 53% with 5 or more relatives, P = 0.02, heard from more friends monthly (84% versus 53% with 3 or more friends, P = 0.02, less overall symptom distress (P = 0.03, less insomnia (P = 0.003, better concentration (P = 0.005, better outlook (P = 0.01, and less depression (P = 0.005 than younger patients.Conclusions: Younger subjects reported worse symptoms, a smaller social support network, and fewer close friends and relatives than older subjects. Having someone to discuss decisions and seeing friends or relatives often was associated with longer survival. Keywords: social support, Lubben scale, QOL, elderly

  12. Eventos de Mayo (May Events).

    Science.gov (United States)

    Toro, Leonor; Pla, Myrna

    Designed as a resource for teachers, this booklet, written in Spanish, contains brief information on seven May events: La Semana de la Educacion (first Friday in May), Harry S. Truman (May 8), Dia de las Madres (second Sunday in May), Luis Llorens Torres (May 14), La Cruz Roja (May 21), John F. Kennedy (May 29), and El Dia De Conmemoracion (May…

  13. Blackrocks Nursing Home, Foxford, Mayo.

    LENUS (Irish Health Repository)

    Joyce, C W

    2014-01-01

    We compared the tensile strength of a novel knotless barbed suture method with a traditional four-strand Adelaide technique for flexor tendon repairs. Forty fresh porcine flexor tendons were transected and randomly assigned to one of the repair groups before repair. Biomechanical testing demonstrated that the tensile strengths between both tendon groups were very similar. However, less force was required to create a 2 mm gap in the four-strand repair method compared with the knotless barbed technique. There was a significant reduction in the cross-sectional area in the barbed suture group after repair compared with the Adelaide group. This would create better gliding within the pulley system in vivo and could decrease gapping and tendon rupture.

  14. Eventos de Mayo (May Events).

    Science.gov (United States)

    Toro, Leonor; Pla, Myrna

    Designed as a resource for teachers, this booklet, written in Spanish, contains brief information on seven May events: La Semana de la Educacion (first Friday in May), Harry S. Truman (May 8), Dia de las Madres (second Sunday in May), Luis Llorens Torres (May 14), La Cruz Roja (May 21), John F. Kennedy (May 29), and El Dia De Conmemoracion (May…

  15. Information to go: Kommunikation im Prozess der Migration am Beispiel syrischer und irakischer Flüchtlinge auf ihrem Weg nach Deutschland

    Directory of Open Access Journals (Sweden)

    Anke Fiedler

    2016-07-01

    Full Text Available Vor dem Hintergrund der Flüchtlingsdebatte in Deutschland 2015 wird in diesem Beitrag danach gefragt, welche (Massen-Kommunikationskanäle Flüchtlinge vor, während und nach der Flucht nutzen, um sich über migrationsrelevante Themen zu informieren und sich darüber mit anderen Migrationswilligen auszutauschen. Dabei wird nicht nur die Frage nach der subjektiven Bewertung der genutzten Quellen gestellt, sondern auch untersucht, ob die Flüchtlinge eine informierte Entscheidung in den verschiedenen Phasen der Migration treffen. Auf Basis des Uses-and-Gratifications-Ansatzes und der Handlungstheorie (symbolischer Interaktionismus wurden zwischen November 2015 und Februar 2016 vier Fokusgruppen und 36 Tiefeninterviews mit syrischen und irakischen Flüchtlingen durchgeführt. Die Ergebnisse verdeutlichen, dass sich die befragten Flüchtlinge vor und während der Flucht gut informiert fühlten, da persönliche Kontakte und soziale Medien die Informationsbedürfnisse weitgehend befriedigen konnten. Informationsdefizite zeigten sich vor allem nach der Ankunft in Deutschland.

  16. Virus influenza y el diagnóstico diferencial de sintomáticos febriles en la costa norte del Perú (Mayo, 2001

    Directory of Open Access Journals (Sweden)

    Yvonne Torres de Yon

    2004-01-01

    Full Text Available Objetivo: Identificar el virus influenza y otros agentes etiológicos relacionados con la presentación de síndrome febril en los departamentos de Piura, Tumbes, Lambayeque y La Libertad, en mayo de 2001. Material y Métodos: Estudio descriptivo, transversal. Incluye pacientes febriles que acudieron a los puestos de salud centinelas y que presentaban fiebre mayor de 38°C y gota gruesa negativa. Se obtuvieron dos muestras de sangre con un intervalo de 15-45 días. Se registró la sintomatología asociada a fiebre, y se determinó la presencia de anticuerpos mediante pruebas serológicas para dengue, influenza, sarampión y rubéola, además de pruebas para aislamiento y tipificación viral. Resultados: Se registraron 174 pacientes, 58,6% de ellos mujeres, siendo el grupo etáreo más frecuente de menores de 16 años (32,2%. Además de la fiebre se informaron como síntomas más frecuentes el dolor de cabeza (90,1% y dolor de huesos (81,9%. En 89 pacientes (51,1% se pudo obtener muestras de sueros pareados, los cuales fueron incluidos en el estudio serológico; 62 pacientes (69,6% presentaron serología positiva para dengue, 53 (59,5% para influenza y sólo uno (1,1% para rubéola. Conclusiones: El diagnóstico diferencial de pacientes sintomáticos febriles en los departamentos de la costa norte del Perú, luego de descartarse malaria, debe incluir además entre otras etiologías al virus influenza. Un diagnóstico diferencial adecuado permitirá un tratamiento precoz y efectivo. Se hace necesario implementar la vigilancia epidemiológica para mejorar el diagnóstico diferencial en sintomáticos febriles, que incluya a influenza.

  17. Pygoscelis antarcticus feathers as bioindicator of trace element risk in marine environments from Barton Peninsula, 25 de Mayo (King George) Island, Antarctica.

    Science.gov (United States)

    Catán, Soledad Perez; Bubach, Debora; Di Fonzo, Carla; Dopchiz, Laura; Arribére, Maria; Ansaldo, Martin

    2017-04-01

    We report the contents of elements in feathers of Chinstrap penguin (Pygoscelis antarcticus), which had not been informed up to now, such as silver and bromine and others listed as hazardous by the United States Environmental Protection Agency as arsenic, cobalt, chromium, and mercury. Analyses of the element concentrations in feathers, adult and chicken, from Barton Peninsulas at 25 de Mayo (King George) Island, South Shetlands, were made by Instrumental Neutron Activation Analysis. Samarium, lanthanum a, thorium, and uranium concentrations in Chinstrap penguin feathers were below 0.1 mg/kg. This suggests that the elements in feather do not come from atmospheric particles surface deposition. Arsenic (0.120 ± 0.050 mg/kg) and cobalt (0.030 ± 0.020 mg/kg) concentrations were lower than the reports for other colony of Chinstrap penguins, and essential elements as iron (26 ± 12 mg/kg), zinc (78.0 ± 5.3 mg/kg), and chromium (0.51 ± 0.27 mg/kg) were in the same range while Se (2.90 ± 0.65 mg/kg) content were the lowest reported. Mercury (0.43 ± 0.21 mg/kg), chromium (0.210 ± 0.060 mg/kg), and silver (0.083 ± 0.003 mg/kg) in chicks tended to be lower than in adults. Iron, cobalt, and arsenic concentrations in feathers found in this study were the lowest compared to measurements were in several penguin species in Antarctica. These results confirm to feathers like effective indicators for the trace elements incorporated in the penguins and it provide a data set which can adds to the baseline for bioindication studies using feathers.

  18. Cambios morfológicos recientes en lagos de la península Potter, isla 25 de Mayo, islas Shetland del Sur, Antártida

    Directory of Open Access Journals (Sweden)

    R.A. del Valle

    2004-09-01

    Full Text Available Aunque la historia ambiental del Holoceno-Reciente de los lagos antárticos informada en este trabajo es menos espectacular que la historia de los grandes paleolagos patagónicos formados al este de los Andes durante el Pleistoceno tardío-Holoceno temprano, la evidencia paleoambiental sugiere que recurrentes cambios de las vías de drenaje acompañados por descensos escalonados del nivel de lagos proglaciales antárticos también fueron probablemente disparados por episodios de desglaciación. Este trabajo está enfocado en los lagos mayores de la península Potter (62°15´S, 58°40´O, isla 25 de Mayo (Islas Shetland del Sur, Antártida, los cuales se formaron entre morenas neoglaciales depositadas por el frente retrocedente del campo de hielo de la península, durante el Holoceno tardío-Reciente. Después de alcanzar su altura máxima, el nivel de estos lagos descendió en forma escalonada por la apertura de canales de drenaje ubicados progresivamente a menor altitud. Estos drenajes ocuparon antiguos valles sucesivamente abandonados por glaciares de descarga del campo de hielo de la península. Testigos sedimentarios obtenidos en las cuencas lacustres estudiadas indican que allí la depositación glaciaria alternó con la formación de varves clásticos, lo cual probablemente refleja las rápidas fluctuaciones del frente de los glaciares que caracterizan a la parte más reciente del Holoceno en la región. Sólo se pudo acotar imprecisamente en <5500 años antes del presente, la edad máxima de uno de los cambios de drenaje del lago más antiguo estudiado en este trabajo. El cambio de drenaje del lago más joven ocurrió en el verano austral de 1999-2000, lo cual sugiere que el proceso de desglaciación y la consecuente desestabilización del permafrost y los diques morénicos de los lagos en la península Potter probablemente continúan activos.

  19. ¿Retirarse a tiempo? La visión del Mayo del 68 francés en la España Contemporánea

    Directory of Open Access Journals (Sweden)

    Álvaro Fleites Marcos

    2009-12-01

    Full Text Available El presente artículo tiene por objeto examinar la imagen de los acontecimientos franceses conocidos en su conjunto como la “crisis de mayo de 1968” en la España franquista contemporánea. En primer lugar, las autoridades franquistas mostraron un gran temor ante la posible extensión de las revueltas a España e intentaron establecer un cordón sanitario sobre las noticias procedentes de Francia, que la prensa española no tardó en romper aprovechando la nueva libertad consecuencia de la ley Fraga de 1966. Sin embargo, si los diferentes diarios adoptaron posturas inicialmente divergentes ante los acontecimientos, con la significativa excepción de Calvo Serer y Madrid terminaron por apoyar la restauración del orden llevada a cabo por el régimen gaullista. Por último, los informes de los diplomáticos galos en misión en España, conservados en los Archives du Ministère français des Affaires Étrangères muestran a una opinión pública española mayoritariamente favorable al gobierno francés y comprensiva con su situación, lo que se contradice con la postura del Partido Comunista Español, favorable a las revueltas._____________________ABSTRACT:This article examines the image of the French events known as the May 1968 crisis in contemporary Spain. The Franco government was frightened by the possibility of the revolts spreading to Spain so that it tried to establish a cordon sanitaire to prevent the news of the gravity of the French events from reaching the Spanish people. However, the Spanish press profited from the theoretical freedom brought by the new Fraga press law of 1966 and initially continued to inform about the seriousness of the revolts. Anyway, all the journals but Calvo Serer´s Madrid supported in the end the French government and its policy of restoring order. Finally, the reports from the French diplomats in Madrid, conserved in the Archives du Ministère français des Affaires Étrangères, show a Spanish public

  20. Abbreviation and acronym disambiguation in clinical discourse.

    Science.gov (United States)

    Pakhomov, Sergeui; Pedersen, Ted; Chute, Christopher G

    2005-01-01

    Use of abbreviations and acronyms is pervasive in clinical reports despite many efforts to limit the use of ambiguous and unsanctioned abbreviations and acronyms. Due to the fact that many abbreviations and acronyms are ambiguous with respect to their sense, complete and accurate text analysis is impossible without identification of the sense that was intended for a given abbreviation or acronym. We present the results of an experiment where we used the contexts harvested from the Internet through Google API to collect contextual data for a set of 8 acronyms found in clinical notes at the Mayo Clinic. We then used the contexts to disambiguate the sense of abbreviations in a manually annotated corpus.

  1. Acción colectiva, visibilidad y espacio público en la construcción de la ciudadanía. Los cortes de puentes de mayo del 97 en San Salvador de Jujuy

    Directory of Open Access Journals (Sweden)

    Lic. Alejandra García Vargas

    2000-01-01

    Full Text Available Salvador de Jujuy es la ciudad capital de la provincia de Jujuy, Argentina. En mayo de 1997, y paralelamente a cortes de rutas en todo el territorio provincial, parte de sus habitantes interrumpieron el tránsito sobre los puentes del río Chico o Xibi Xibi, que atraviesa la ciudad. Este trabajo propone analizar, a partir de entrevistas a participantes de los cortes y artículos de la prensa gráfica local, las características de esta acción colectiva y su vinculación con la construcción de la ciudadanía.

  2. Aplicabilidad de los aportes de Elton Mayo en la gestión de las pequeñas y medianas organizaciones de la ciudad de Bahía Blanca

    OpenAIRE

    Cabrera, Cecilia; Schwerdt, Fabio Adrián

    2014-01-01

    La presente ponencia se orienta a identificar los aportes más significativos de la Escuela de Relaciones Humanas iniciada por el psicólogo austríaco Elton Mayo, y compararlos con su actual aplicabilidad en la gestión de Pequeñas y Medianas organizaciones de la localidad de Bahía Blanca. Se intenta averiguar cuáles de los aportes de este autor se emplean en el contexto actual, signado por cambiantes circunstancias políticas, económicas, sociales y culturales, que generan un ambiente externo...

  3. Procedimiento de obtención de nanopartículas de fosfato de calcio amorfo recubiertas de citrato y dopadas con flúor

    OpenAIRE

    Delgado López, José Manuel; J. Gómez-Morales; Fernández Penas, Raquel; Iafisco, Michele; Tampieri, Anna; Panseri, Silvia

    2014-01-01

    Procedimiento de obtención de nanopartículas de fosfato de calcio amorfo recubiertas de citrato y dopadas con flúor. Este material presenta aplicaciones en biomedicina por su excelente biodegradabilidad y bioactividad; además promueve la adhesión celular y osteogeneración. En odontología, puede utilizarse en pastas dentales, enjuagues bucales, goma de mascar, geles y barnices de flúor como agente remineralizante de dentina y esmalte. Parte de dos disoluciones formadas por cloruro cálcico y ci...

  4. Procedimiento de obtención de nanopartículas de fosfato de calcio amorfo recubiertas de citrato y dopadas con flúor

    OpenAIRE

    Delgado López, José Manuel; Gómez-Morales, J.; Fernández Penas, Raquel; Iafisco, Michele; Tampieri, Anna; Panseri, Silvia

    2014-01-01

    Procedimiento de obtención de nanopartículas de fosfato de calcio amorfo recubiertas de citrato y dopadas con flúor. Este material presenta aplicaciones en biomedicina por su excelente biodegradabilidad y bioactividad; además promueve la adhesión celular y osteogeneración. En odontología, puede utilizarse en pastas dentales, enjuagues bucales, goma de mascar, geles y barnices de flúor como agente remineralizante de dentina y esmalte. Parte de dos disoluciones formadas por cloruro cálcico y ci...

  5. Identification of a 4-Deoxy-l-erythro-5-hexoseulose Uronic Acid Reductase, FlRed, in an Alginolytic Bacterium Flavobacterium sp. Strain UMI-01

    Directory of Open Access Journals (Sweden)

    Akira Inoue

    2015-01-01

    Full Text Available In alginate-assimilating bacteria, alginate is depolymerized to unsaturated monosaccharide by the actions of endolytic and exolytic alginate lyases (EC 4.2.2.3 and EC 4.2.2.11. The monosaccharide is non-enzymatically converted to 4-deoxy-l-ery thro-5-hexoseulose uronic acid (DEH, then reduced to 2-keto-3-deoxy-d-gluconate (KDG by a specific reductase, and metabolized through the Entner–Doudoroff pathway. Recently, the NADPH-dependent reductase A1-R that belongs to short-chain dehydrogenases/reductases (SDR superfamily was identified as the DEH-reductase in Sphingomonas sp. A1. We have subsequently noticed that an SDR-like enzyme gene, flred, occurred in the genome of an alginolytic bacterium Flavobacterium sp. strain UMI-01. In the present study, we report on the deduced amino-acid sequence of flred and DEH-reducing activity of recombinant FlRed. The deduced amino-acid sequence of flred comprised 254 residues and showed 34% amino-acid identities to that of A1-R from Sphingomonas sp. A1 and 80%–88% to those of SDR-like enzymes from several alginolytic bacteria. Common sequence motifs of SDR-superfamily enzymes, e.g., the catalytic tetrad Asn-Lys-Tyr-Ser and the cofactor-binding sequence Thr-Gly-x-x-x-Gly-x-Gly in Rossmann fold, were completely conserved in FlRed. On the other hand, an Arg residue that determined the NADPH-specificity of Sphingomonas A1-R was replaced by Glu in FlRed. Thus, we investigated cofactor-preference of FlRed using a recombinant enzyme. As a result, the recombinant FlRed (recFlRed was found to show high specificity to NADH. recFlRed exhibited practically no activity toward variety of aldehyde, ketone, keto ester, keto acid and aldose substrates except for DEH. On the basis of these results, we conclude that FlRed is the NADH-dependent DEH-specific SDR of Flavobacterium sp. strain UMI-01.

  6. New Cosmic Center Universe Model Matches Eight of Big Bang's Major Predictions Without The F-L Paradigm

    CERN Document Server

    Gentry, R V

    2003-01-01

    Accompanying disproof of the F-L expansion paradigm eliminates the basis for expansion redshifts, which in turn eliminates the basis for the Cosmological Principle. The universe is not the same everywhere. Instead the spherical symmetry of the cosmos demanded by the Hubble redshift relation proves the universe is isotropic about a nearby universal Center. This is the foundation of the relatively new Cosmic Center Universe (CCU) model, which accounts for, explains, or predicts: (i) The Hubble redshift relation, (ii) a CBR redshift relation that fits all current CBR measurements, (iii) the recently discovered velocity dipole distribution of radiogalaxies, (iv) the well-known time dilation of SNeIa light curves, (v) the Sunyaev-Zeldovich thermal effect, (vi) Olber's paradox, (vii) SN dimming for z 1 an enhanced brightness that fits SN 1997ff measurements, (ix) the existence of extreme redshift (z > 10) objects which, when observed, will further distinguish it from the big bang. The CCU model also plausibly expl...

  7. Bodipy-FL-Verapamil: A Fluorescent Probe for the Study of Multidrug Resistance Proteins

    Directory of Open Access Journals (Sweden)

    Anna Rosati

    2004-01-01

    Full Text Available Most of the substances used as fluorescent probes to study drug transport and the effect of efflux blockers in multidrug resistant cells have many drawbacks, such as toxicity, unspecific background, accumulation in mitochondria. New fluorescent compounds, among which Bodipy‐FL‐verapamil (BV, have been therefore proposed as more useful tools. The uptake of BV has been evaluated by cytofluorimetry and fluorescence microscopy using cell lines that overexpress P‐glycoprotein (P388/ADR and LLC‐PK1/ADR or MRP (multidrug resistance‐related protein (PANC‐1 and clinical specimens from patients. The effect of specific inhibitors for P‐glycoprotein (verapamil and vinblastine or MRP (MK571 and probenecid has been also studied. BV intracellular concentrations were significantly lower in the two P‐glycoprotein overexpressing cell lines in comparison with the parental lines. In addition, verapamil and vinblastine increased the intracellular concentrations of the dye; MK571 and probenecid, two MRP inhibitors, increased BV levels in PANC‐1 cells, that express this protein. These findings were confirmed in clinical specimens from patients. Fluorescence microscopy revealed a faint fluorescence emission in P‐glycoprotein or MRP expressing cell lines; however, treatment with specific inhibitors significantly increased the fluorescence. BV is a useful tool for studying multidrug resistance proteins with different techniques such as cytofluorimetry and fluorescence microscopy, but does not discriminate between P‐glycoprotein and MRP. In comparison with other classic fluorescent probes, the assay with this dye is extremely rapid, simple, not toxic for cells, devoid of fluorescent background, and can be useful in the clinical settings.

  8. Cambios morfológicos recientes en lagos de la península Potter, isla 25 de Mayo, islas Shetland del Sur, Antártida Recent morphological changes in the Peninsula Potter lakes, 25 de Mayo Island, Southern Shetland Islands, Antarctica

    Directory of Open Access Journals (Sweden)

    R.A. del Valle

    2004-09-01

    Full Text Available Aunque la historia ambiental del Holoceno-Reciente de los lagos antárticos informada en este trabajo es menos espectacular que la historia de los grandes paleolagos patagónicos formados al este de los Andes durante el Pleistoceno tardío-Holoceno temprano, la evidencia paleoambiental sugiere que recurrentes cambios de las vías de drenaje acompañados por descensos escalonados del nivel de lagos proglaciales antárticos también fueron probablemente disparados por episodios de desglaciación. Este trabajo está enfocado en los lagos mayores de la península Potter (62°15´S, 58°40´O, isla 25 de Mayo (Islas Shetland del Sur, Antártida, los cuales se formaron entre morenas neoglaciales depositadas por el frente retrocedente del campo de hielo de la península, durante el Holoceno tardío-Reciente. Después de alcanzar su altura máxima, el nivel de estos lagos descendió en forma escalonada por la apertura de canales de drenaje ubicados progresivamente a menor altitud. Estos drenajes ocuparon antiguos valles sucesivamente abandonados por glaciares de descarga del campo de hielo de la península. Testigos sedimentarios obtenidos en las cuencas lacustres estudiadas indican que allí la depositación glaciaria alternó con la formación de varves clásticos, lo cual probablemente refleja las rápidas fluctuaciones del frente de los glaciares que caracterizan a la parte más reciente del Holoceno en la región. Sólo se pudo acotar imprecisamente en Although the Holocene-Recent environmental history of the Antarctic lakes reported in this paper is less spectacular than that of the big proglacial palaeolakes formed on the eastern flank of the Andes of southern Patagonia during the late Pleistocene-early Holocene, palaeoenvironmental evidence suggests that recurrent changes in drainage accompanied by the stepped descent of Antarctic proglacial lakes were also probably triggered by the deglaciation event, which may have shifted southward in high

  9. The Influence of Technology in the Classroom: An Analysis of an iPad and Video Intervention on JHS Students' Confidence, Anxiety, and FL WTC

    Science.gov (United States)

    Ockert, David Michael

    2014-01-01

    This small-scale, longitudinal study tested for the influence of video recording with a camcorder, and recording and self-viewing with an iPad. The study tested for changes in confidence, anxiety and foreign language (FL) willingness to communicate (WTC; McCroskey & Baer, 1985) using self-report measures before and after the intervention (N =…

  10. 76 FR 16637 - J.N. “Ding” Darling NWR, Lee County, FL; Final Comprehensive Conservation Plan and Finding of No...

    Science.gov (United States)

    2011-03-24

    ... Fish and Wildlife Service J.N. ``Ding'' Darling NWR, Lee County, FL; Final Comprehensive Conservation... impact (FONSI) for the environmental assessment for J.N. ``Ding'' Darling National Wildlife Refuge (NWR... INFORMATION: Introduction With this notice, we finalize the CCP process for J.N. ``Ding'' Darling NWR....

  11. Indicios futuristas en la estética y la obra literaria de Wenceslao Fernández Flórez

    OpenAIRE

    Couto Cantero, Pilar

    2016-01-01

    El presente artículo estudia la conexión existente entre el escritor Wenceslao Fernández Flórez y la corriente futurista de principios del siglo XX. Los dos primeros apartados abordan el estado de la cuestión en Galicia y el modo en que los escritore

  12. 33 CFR 334.540 - Banana River at the Eastern Range, 45th Space Wing, Cape Canaveral Air Force Station, FL...

    Science.gov (United States)

    2010-07-01

    ..., 45th Space Wing, Cape Canaveral Air Force Station, FL; restricted area. 334.540 Section 334.540... enforced by the Commander, 45th Space Wing, Patrick Air Force Base, Florida and/or such persons or agencies... AND RESTRICTED AREA REGULATIONS § 334.540 Banana River at the Eastern Range, 45th Space Wing,...

  13. Enhanced immune response and protective effects of nano-chitosan-based DNA vaccine encoding T cell epitopes of Esat-6 and FL against Mycobacterium tuberculosis infection.

    Directory of Open Access Journals (Sweden)

    Ganzhu Feng

    Full Text Available Development of a novel and effective vaccine against Mycobacterium tuberculosis (M.tb is a challenging for preventing TB infection. In this study, a novel nanoparticle-based recombinant DNA vaccine was developed, which contains Esat-6 three T cell epitopes (Esat-6/3e and fms-like tyrosine kinase 3 ligand (FL genes (termed Esat-6/3e-FL, and was enveloped with chitosan (CS nanoparticles (nano-chitosan. The immunologic and protective efficacy of the nano-chitosan-based DNA vaccine (termed nano-Esat-6/3e-FL was assessed in C57BL/6 mice after intramuscular prime vaccination with the plasmids DNA and nasal boost with the Esat-6/3e peptides. The results showed that the immunized mice remarkably elicited enhanced T cell responses and protection against M.tb H37Rv challenge. These findings indicate that the nano-chitosan can significantly elevate the immunologic and protective effects of the DNA vaccine, and the nano-Esat-6/3e-FL is a useful vaccine for preventing M.tb infection in mice.

  14. STR data for the AmpFlSTR Profiler loci from the three main ethnic population groups (Malay, Chinese and Indian) in Malaysia.

    Science.gov (United States)

    Lim, K B; Jeevan, N H; Jaya, P; Othman, M I; Lee, Y H

    2001-06-01

    Allele frequencies for the nine STRs genetic loci included in the AmpFlSTR Profiler kit were obtained from samples of unrelated individuals comprising 139-156 Malays, 149-153 Chinese and 132-135 Indians, residing in Malaysia.

  15. Avaliação da concentração de flúor e do consumo de água mineral

    Directory of Open Access Journals (Sweden)

    Ramires Irene

    2004-01-01

    Full Text Available OBJETIVO: Considerando a água como importante fonte de ingestão de flúor, o aumento da prevalência de fluorose dentária e do consumo de água mineral, o estudo realizado teve como objetivo avaliar o consumo de água mineral e sua concentração de flúor. MÉTODOS: A pesquisa foi realizada nos bairros do município de Bauru, SP. Foram visitadas mil residências que compunham uma amostra estratificada, obtida por conglomerados. Cada conglomerado correspondia a um quarteirão. Para efeito de sorteio os quarteirões foram numerados dentro das 17 regiões estabelecidas no plano diretor do município. Para coleta das amostras de água mineral foram usados frascos plásticos de 50 ml, previamente identificados. Na análise de flúor utilizou-se eletrodo íon sensível (Orion 9609 após tamponamento com TISAB II. Informações a respeito do consumo de água mineral foram obtidas com a aplicação de um questionário. RESULTADOS: Constatou-se que cerca de 29,7% da população do município consome água mineral. Nas 260 amostras analisadas, das 29 diferentes águas, a concentração de flúor variou de 0,045 a 1,515 mg/l. Em uma das águas, constava no rótulo o valor de 0,220 mg/l, mas na análise constatou-se 1,515 mg/l de flúor. Além disso, algumas águas não traziam especificado a concentração de flúor; e, na análise constataram-se valores variando entre 0,049 e 0,924 mg/l. CONCLUSÕES: Os resultados mostraram uma grande variação na concentração de flúor e reforçam a importância do controle dessas águas por parte da vigilância sanitária.

  16. Orthodontic cements: immediate protection and fluoride release Cimentos ortodônticos: proteção imediata e liberação de flúor

    Directory of Open Access Journals (Sweden)

    Rogério Lacerda dos Santos

    2012-08-01

    Full Text Available OBJECTIVES: The objective of the authors was to evaluate fluoride release of 3 glass ionomer cements with immediate protection of fluoride varnish (Cavitine, SS White, divided into 3 groups: Group M (Meron, VOCO, Group V (Vidrion C, SS White and Group KC (Ketac-Cem, 3M ESPE. METHODS: Fluoride release was measured during 60 days by means of an ion-selective electrode connected to an ion analyzer. After 4 weeks, the test specimens were exposed to a solution of 0.221% sodium fluoride (1000 ppm of fluoride. RESULTS: Results showed that the cements reached a maximum peak of fluoride release in a period of 24 h. There was a statistically significant difference between the amount of fluoride released after the applications of fluoride among the groups from the 31st to 60th day (p> 0.05. CONCLUSION: The Vidrion C and Meron cements showed better performance to uptake and release fluoride when compared with Ketac-Cem cement.OBJETIVO: o objetivo desse estudo foi avaliar a liberação de flúor dos seguintes três cimentos de ionômero de vidro, com proteção imediata de verniz fluoretado (Cavitine, S. S. White: Meron / VOCO (Grupo M; Vidrion C / S. S. White (Grupo V; e Ketac Cem / 3M ESPE (Grupo KC. MÉTODOS: a liberação de flúor foi medida durante 60 dias, através de eletrodo íon seletivo conectado a um analisador de íons. Após quatro semanas, os corpos de prova foram expostos a uma solução de fluoreto de sódio a 0,221% (1.000ppm de flúor. RESULTADOS: os resultados evidenciaram que os cimentos atingiram o pico máximo de liberação de flúor com 24h após a presa inicial. Houve diferença estatisticamente significativa entre os grupos, quanto à quantidade de flúor liberado após as aplicações de flúor, do 31º ao 60° dia (p > 0,05. CONCLUSÃO: os cimentos Meron e Vidrion apresentaram maior capacidade de captação e liberação de flúor, em comparação ao cimento Ketac Cem.

  17. Fluoride content of several breakfast cereals and snacks found in Brazil Conteúdo de flúor em diversos cereais matinais e salgadinhos encontrados no Brasil

    Directory of Open Access Journals (Sweden)

    Vanessa Eid da Silva Cardoso

    2003-12-01

    Full Text Available Breakfast cereals and snacks are foodstuffs highly appreciated by children, and the possibility that they contain substantial amounts of fluoride, associated with their widespread consume, may make them important contributors to the total daily fluoride intake. The aim of this study was to analyze the fluoride content on several breakfast cereals (A and snacks (B purchased in Brazil. The analysis were made after HMDS-facilitated diffusion (Taves using the ion-specific electrode (9609. Mean fluoride concentrations ± SD (range, unit mg F/g were: A= 0.76 ± 0.60 (0.08-1.86, n=15 and B= 0.32 ± 0.09 (0.22-0.55, n=18. Our results suggest that the total amount of fluoride available in some products may contribute to the total daily fluoride intake. The product labels should provide information on their fluoride content to prevent fluorosis at the age of risk.Cereais matinais e salgadinhos são guloseimas altamente apreciadas pelas crianças, e a possibilidade de conterem quantidades substanciais de flúor, associada ao seu indiscriminado consumo, pode torná-los importantes contribuintes para a ingestão diária total de flúor. O objetivo deste estudo foi analisar o conteúdo de flúor em diversos cereais matinais (A e salgadinhos (B adquiridos no Brasil. As análises foram feitas após difusão facilitada por HMDS (Taves, usando o eletrodo íon específico (9609. As concentrações médias de flúor ± SD (amplitude, unidade mg F/g foram: A= 0,76 ± 0,60 (0,08-1,86, n=15 e B= 0,32 ± 0,09 (0,22-0,55, n=18. Nossos resultados sugerem que a quantidade de flúor presente em alguns produtos pode contribuir com a ingestão diária total de flúor. Os rótulos dos produtos deveriam informar seu conteúdo de flúor para prevenir fluorose no período de risco.

  18. Flávio Damm, profissão fotógrafo de imprensa: o fotojornalismo e a escrita da história contemporânea Flávio Damn, profession press photographer

    Directory of Open Access Journals (Sweden)

    Ana Maria Mauad

    2005-01-01

    Full Text Available O artigo tem como proposta analisar a relação entre a fotografia de imprensa e a escrita da história contemporânea. Apóia-se nos estudos sobre a história da memória do fotojornalismo brasileiro, orientados pela metodologia da história oral e do uso da fotografia na análise historiográfica. O foco central incide sobre a trajetória do fotógrafo gaúcho Flávio Damm e sua primeira reportagem de impacto, publicada na Revista do Globo, em 1948, sobre o retorno de Getúlio Vargas à cena política após o Estado Novo. Discute-se, a partir deste estudo de caso, as relações entre as palavras e as imagens na elaboração das chamadas fontes de memória, a produção do acontecimento pela mídia e sua repercussão na memória contemporânea, e por fim, a capacidade narrativa da imagem fotográfica e sua relação com a escrita da história renovada pela introdução de fontes não tradicionais - orais e visuais.The article discusses the relationship between press photographs and the writing of contemporary history. Based upon the studies about history of the Brazilian memory, photojournalism, this work is methodologically oriented by oral history researches and the uses of photography in history. The central focus relied on the analysis of the Brazilian photographer Flávio Damm, and his first impact reportage, published at Revista do Globo, in 1948, about the return of Getulio Vargas to the political scene after the Estado Novo. From this case study the article analyses the relationship between words and images, and its contribution on the building of the so-called sources of memory; the impact of the media on the contemporary memory; and finally, the capacity of the photography image in narrating and building a historical writing, renewed by the uses of non-traditional sources - oral and visual.

  19. Bernard de Gordon (fl. 1270-1330): medieval physician and teacher.

    Science.gov (United States)

    Pearn, John

    2013-02-01

    The Montpellier physician Bernard de Gordon flourished in the late Middle Ages in the era when university education first evolved in the training of European physicians. Fragmentary details of his life and medical influence are known from seven books, particularly his extensive (163 chapters) text Lilium Medicine and from Chaucer's reference to him in the Canterbury Tales. Chaucer lists Bernard de Gordon as one whose writings were part of the core curriculum of the best-trained European doctors of medieval Europe. Bernard de Gordon was one of that small group of medieval physicians who reverently followed Galenic lore which had endured for a thousand years yet who began to challenge its details and to experiment clinically with new methods of treatment. In his writings, Bernard de Gordon made the first reference to spectacles and to the hernial truss. His writings also contained detailed desiderata for the ethical best practice of medicine of his day, extending the principles of both Hippocrates and Haly ibn Abbas. Unlike many of the surviving writings of other medieval medical teachers, his texts have within them a tone of humility and acknowledged fallibility. Bernard de Gordon holds a small but significant place in the evolving pre-Renaissance chronology of medical professionalism.

  20. Expression analysis of antioxidant genes in response to drought stress in the fl ag leaf of two Indonesian rice cultivars

    Directory of Open Access Journals (Sweden)

    Refli R

    2015-12-01

    Full Text Available The objective of this study was to analysis the expression of antioxidant genes in response to droughtstress in Indonesian rice. The malondialdehyde (MDA content and the expression of Cu-ZnSod1, cCu-ZnSod2,MnSod1, cApxa, cApxb, chl-sApx, Cat1, Cat2, Cat3, Gr1, Gr2, and Gr3 genes were assayed in the rice fl ag leaf ofCiherang and Situ Bagendit cultivars subjected to control, mild and severe drought during the grain fi llingphase. Increase in MDA content of Ciherang treated to mild and severe drought was almost two-fold andthree-fold respectively, while MDA content in Situ Bagendit subjected to mild and severe drought increasedapproximately one-fold and two-fold as compared to the control. The semi quantitative reverse transcriptionpolymerase chain reaction (sqRT-PCR analysis showed that the expression of cCu-ZnSod1, MnSod1, Cat2, Gr3genes of Ciherang, and cCu-ZnSod2, MnSod1, cApxa, cApxb, chl-sAPX, Cat2 and Gr1 genes of Situ Bagendit increasedin fl ag leaf of plant treated to drought. Expressions of cApxb, chl-sApx, Cat3 of Ciherang and Cu-ZnSod1 and Gr2genes of Situ Bagendit were not changed signifi cantly by drought stress. Decreased expression was shownby cCu-ZnSod2, cApxa, Cat1, Gr1 and Gr2 genes of Ciherang, and Cat1, Cat3 and Gr3 genes of Situ Bagendit. Theresults indicated that the activity of oxidative defense was regulated by four genes; cCu-ZnSod1, MnSod1, Cat2,Gr3 in Ciherang, and eight genes; cCu-ZnSod1, cCu-ZnSod2, MnSod1, cApxa, cApxb, chl-sApx, Cat2 and Gr1 in SituBagendit. Therefore, differences in the number of antioxidant genes controlling oxidative defense systemmight determine the difference of the oxidative defense capacity between both cultivars in response to droughtstress during grain fi lling.

  1. Prácticas de estimulación y promoción del desarrollo infantil en la etnia Mayo Stimulation practices and promotion of child development in Maya ethnicity

    Directory of Open Access Journals (Sweden)

    José Ángel Vera Noriega

    2010-12-01

    Full Text Available En este estudio se identificaron las características de las prácticas de estimulación y promoción del desarrollo en una comunidad indígena Mayo del estado de Sonora y Sinaloa en el noroeste de México. Se evaluaron dos grupos de 50 madres cada uno: un primer grupo que llamaremos de resistencia étnica, hablaba la lengua mayo a sus hijos y participaba en un programa educativo no escolarizado cuyo objeto es estimular el desarrollo. Un segundo grupo de madres que llamaremos de asimilación étnica, no hablaba la lengua mayo y no pertenecía al programa educativo. Se realizó mediante la aplicación de entrevistas a las madres y con escalas de desarrollo psicológico para niños de 0 y 5 años de edad. Los resultados indican que la población no hablante y sin educación inicial (asimilación étnica presenta baja frecuencia en el rango de problemas en el desarrollo y estimulación del niño en el hogar, comparado con la población hablante y con educación inicial (resistencia étnica. Se concluye en términos de un modelo intercultural de educación inicial para población indígena.In this study the characteristics of stimulation practices and developmental practices in an indigenous Maya community from the state of Sonora and Sinaloa in the northwestern part of Mexico have been evaluated. Two groups of 50 mothers each: the first group, which we will call ethnic resistance, spoke the Mayan language to their children and participated in a non-schooled educational program of development stimulation. A second group of mothers which we will call ethnic assimilation did not speak the Mayan language and didn't belong to the initial educational program. It was accomplished by the application of interviews to mothers with the scales of psychological development for children ranging from 0 to 5 years of age. The results indicate that the non-speaking population and without the initial education (ethnic assimilation present low frequency in the range

  2. Colloqium on Pathogenes, to be held November 6-9, 2003 in Key Largo, FL

    Energy Technology Data Exchange (ETDEWEB)

    Richard J Roberts, PI; Karen C. Cone, Program Director and Report Preparer

    2004-01-01

    The American Academy of Microbiology convened a colloquium November 6-7, 2003, in Key Largo, Florida, to discuss the application of genomic methods to the study of pathogenesis. Professionals in the fields of genomics, bacteriology, virology, eukaryotic microbiology, medicine, clinical diagnostics, bioinformatics, and forensics contributed their expertise to discussions on the recent advancements in the field and the outlook for future research. A number of recommendations were made for ensuring that progress in the field continues. The availability of genome sequences from pathogenic bacteria, viruses, and fungi and other eukaryotes has opened new horizons for the field of pathogenesis. The genomes of over 100 bacterial pathogens have been fully sequenced, and scientists are busy investigating the mechanisms that regulate the diversity of bacterial pathogens and their myriad abilities to evade host defenses. Close to 1,200 viral genomes have been sequenced, and virologists are now beginning to examine the genomes of those viruses that cause undetected, cryptic infections. These virus-host interactions can serve as a reservoir of viral genes that later emerge in novel pathogens with the potential to infect humans, economically important animals, or crops. A number of eukaryotic microbes, including several pathogenic fungi, have also been sequenced, revealing unimagined diversity among these important pathogens. Certain themes have emerged from analyses of pathogen genome sequences, and the possibility exists that a sequence-based “common thread” may be found linking pathogens from different taxa. The results of genome sequencing efforts have also informed the study of pathogenesis, helping to identify the ways in which pathogens bring about disease. The advances of the past several years have been great, and we are closer than ever to a comprehensive understanding of pathogenesis, but much work lies ahead. If the science is to move forward, the genome sequences

  3. Implications for operational control of adult mosquito production in cisterns and wells in St. Augustine, FL using attractive sugar baits.

    Science.gov (United States)

    Qualls, Whitney A; Xue, Rudy; Revay, Edita E; Allan, Sandra A; Müller, Günter C

    2012-11-01

    The aim of this study was to further investigate the use of attractive sugar baits as an effective, inexpensive, and environmentally friendly tool for integrated mosquito management programs. Mosquitoes were offered dyed sugar bait in wells and cisterns in an urban tourist area in St. Augustine, FL. Exit traps were constructed to cover the well and cistern openings so the number of resting and emerging mosquitoes stained by feeding on the sugar bait could be monitored. Four mosquito species were collected from these structures: Aedes albopictus (Skuse), Anopheles crucians (Wiedemann), Culex quinquefasciatus Say, and Toxorhynchites rutilus rutilus (Coquillett). Overall, 90% (1482/1644) of the mosquitoes trapped were stained. In general, the number of mosquitoes stained was significantly greater in wells (Pcisterns (P<0.0001) than the numbers that were not stained by the colored bait. Based on the number of mosquitoes stained, we would have expected considerable mosquito mortality had the sugar bait contained an oral toxin. The results of this study support the concept of using attractive toxic sugar baits as an effective tool for integrated mosquito management.

  4. Ecology of Culiseta Melanura and Other Mosquitoes (Diptera: Culicidae) from Walton County, FL, During Winter Period 2013–2014

    Science.gov (United States)

    Burkett-Cadena, Nathan D.; Bingham, Andrea M.; Hunt, Brenda; Morse, Gary; Unnasch, Thomas R.

    2015-01-01

    Winter ecology of putative vectors of eastern equine encephalomyelitis virus (EEEV) in northern Florida was investigated at field locations with evidence of historic EEEV winter transmission. Light traps and resting shelters were used to sample the mosquito community in the vicinity of eight sentinel flocks throughout the winter period (November–April) of 2013 and 2014 in Walton County, FL. Overall mosquito activity was relatively low, although mosquitoes were captured during each week of the study period. Mosquito activity was linked to morning temperature, and females were captured when ambient morning temperatures were quite low (1–5°C). Anopheles crucians Wiedemann, Culex erraticus (Dyar and Knab), Culex territans Walker, and Culiseta melanura (Coquillett) were the most commonly collected mosquito species (of 20 total species). Analysis of blood-engorged mosquitoes revealed a number of mosquito species feeding upon chickens, other birds, amphibians, and domestic and wild mammals. Cs. melanura fed primarily upon chickens and songbirds (Passeriformes), suggesting that this mosquito species is the likely winter vector of EEEV to sentinel chickens in northern Florida. Both resident and nonresident songbird species were fed upon, constituting 63.9 and 36.1% of total songbird meals, respectively. Our results suggest important roles for Cs. melanura and songbird hosts for the winter transmission of EEEV in northern Florida. PMID:26336227

  5. Conversion of spent mushroom substrate to biofertilizer using a stress-tolerant phosphate-solubilizing Pichia farinose FL7.

    Science.gov (United States)

    Zhu, Hong-Ji; Sun, Li-Fan; Zhang, Yan-Fei; Zhang, Xiao-Li; Qiao, Jian-Jun

    2012-05-01

    To develop high-efficient biofertilizer, an environmental stress-tolerant phosphate-solubilizing microorganism (PSM) was isolated from agricultural wastes compost, and then applied to spent mushroom substrate (SMS). The isolate FL7 was identified as Pichia farinose with resistance against multiple environmental stresses, including 5-45°C temperature, 3-10 pH range, 0-23% (w/v) NaCl and 0-6M ammonium ion. Under the optimized cultivation condition, 852.8 mg/l total organic acids can be produced and pH can be reduced to 3.8 after 60 h, meanwhile, the soluble phosphate content reached 816.16 mg/l. The P. farinose was used to convert SMS to a phosphate biofertilizer through a semi-solid fermentation (SSF) process. After fermentation of 10 days, cell density can be increased to 5.6 × 10(8)CFU/g in biomass and pH in this medium can be decreased to 4.0. SMS biofertilizer produced by P. farinose significantly improved the growth of soybean in pot experiments, demonstrating a tremendous potential in agricultural application. Copyright © 2012 Elsevier Ltd. All rights reserved.

  6. Holoceno marino en la península Potter, Isla 25 de Mayo, Antártida Marine sediments of the early Holocene in the Potter Península, King George Island, Southern Shetland, Antarctica

    Directory of Open Access Journals (Sweden)

    R.A. del Valle

    2007-11-01

    Full Text Available La sucesión sedimentaria del Holoceno temprano expuesta en la terraza marina de 3,77 m s.n.m. en la costa sur de la caleta Potter (Isla 25 de Mayo/King George Island, islas Shetland del Sur, Antártida contiene invertebrados marinos, algas y huesos de foca y pingüino. Dataciones por radiocarbono de huesos de pingüino obtenidos en esta sucesión dieron edades de 7.562 a cal AP (años calibrados antes del Presente y 7.414 a cal AP. Las dataciones indican que los huesos están entre los restos de vertebrados más antiguos del Holoceno hallados en las Islas Shetland del Sur, y pueden ser consideradas como edades mínimas de ocupación por estas aves de las costas de las islas en el Holoceno temprano. Esto indica condiciones interglaciales en esa época, con situación clima/hielo marino similar a la presente y condiciones marinas estacionalmente abiertas.The early Holocene sedimentary succession exposed at the 3.77 m-high marine terrace on the south coast of Potter Cove (King George Island/Isla 25 de Mayo, South Shetland Islands, Antarctica contains marine invertebrates, seaweed and bones of seals and penguins. Radiocarbon dating on penguin bones from this succession yielded 7,562 cal yr BP and 7,414 cal yr BP. These dates suggest that the bones are among the oldest remains of Holocene vertebrates found in South Shetland Islands, and may be considered as minimum ages of penguin occupation of coastal areas on the islands during the early Holocene. This indicates interglacial conditions in this time, with climate/sea ice situation similar to the present and seasonally open marine conditions.

  7. Dynamic Test Mechanism of Weapon Cabin’s Door in FL-24 Wind Tunnel%FL-24风洞武器舱舱门动态试验装置

    Institute of Scientific and Technical Information of China (English)

    黄存栋; 徐来武; 吴继飞; 高鹏

    2014-01-01

    针对先进作战飞机发射或投放武器后,武器舱舱门的高速运动将对周围流场产生强烈干扰的问题,在FL-24风洞中建立了舱门开闭动态模拟试验装置。介绍试验装置的构成,利用舱门和舱内布置的动态及静态压力传感器对如舱门动态载荷特性、舱内气动噪声特性、以及St数变化影响等进行研究,并通过预先分析运动历程,估算驱动舱门所需力矩和电机功率,进行机电系统优化设计,反复调试控制程序,达到舱门转动高速响应、精确定位的目的。试验结果表明:试验装置设计合理,运行可靠,舱门最短开/闭时间约为0.15 s,能够准确模拟舱门高速开闭历程,并可拓展到其他多项试验研究。%Aiming at intense interference on fluid field close to weapon cabin’s door, which takes place before/after launching or injecting of fighting plane’s weapon, a dynamic test mechanism of weapon cabin’s door was established successfully in FL-24 wind tunnel. Constituent of the mechanism is introduced. It was used to research aerodynamic loads of weapon cabin’s door, and aero-acoustic noise of weapon bay, and the influence of theirs with variable St, with dynamic and static pressure sensors that were planted in the door and weapon cavity of the test equipment. The model door can turn responsively and accurately by analysis of rotating process, and calculating of drive torque, and estimate motor power, and optimization design of mechanical-electronic system, and a lot of adjusting on control program. The experimental results indicate that the dynamic test mechanism is designed reasonably and can run reliably. The shortest opening/closing time is about 0.15s of weapon cabin’s door. The system has capacity to simulate opening or closing process of the door precisely. At the same time, more test ability of the mechanism can be expanded.

  8. Mayo肺脏计划关于肺癌发生率的进一步随访及过度诊断结果的评价%Evaluation of Extended Lung Cancer Incidence Follow-up in the Mayo Lung Project and Overdiagnosis

    Institute of Scientific and Technical Information of China (English)

    徐向英; 徐崇锐

    2007-01-01

    @@ 1 文献类型 诊断. 2证据水平 2b. 3文献来源 Marcus PM,Bergstralh EJ,Zweig MH,et al.Extended lung cancer incidence follow-up in the Mayo Lung Project and overdiagnosis[J].J Natl Cancer Inst,2006,98(11):748-756.

  9. Review of Immanuel Kant, Primera Introducción a la Crítica del Juicio, Edición bilingüe. Introducción, edición crítica y traducción de Nuria Sánchez Madrid (Ed. Escolar y mayo: Madrid, 2011).

    OpenAIRE

    Clara Benito Ortiz

    2015-01-01

    Review of   Immanuel Kant, Primera Introducción a la Crítica del Juicio, Edición bilingüe. Introducción, edición crítica y traducción de Nuria Sánchez Madrid (Ed. Escolar y mayo: Madrid, 2011).

  10. Evaluation of the content coverage of SNOMED CT: ability of SNOMED clinical terms to represent clinical problem lists.

    Science.gov (United States)

    Elkin, Peter L; Brown, Steven H; Husser, Casey S; Bauer, Brent A; Wahner-Roedler, Dietlind; Rosenbloom, S Trent; Speroff, Ted

    2006-06-01

    To evaluate the ability of SNOMED CT (Systematized Nomenclature of Medicine Clinical Terms) version 1.0 to represent the most common problems seen at the Mayo Clinic in Rochester, Minn. We selected the 4996 most common nonduplicated text strings from the Mayo Master Sheet Index that describe patient problems associated with inpatient and outpatient episodes of care. From July 2003 through January 2004, 2 physician reviewers compared the Master Sheet Index text with the SNOMED CT terms that were automatically mapped by a vocabulary server or that they identified using a vocabulary browser and rated the "correctness" of the match. If the 2 reviewers disagreed, a third reviewer adjudicated. We evaluated the specificity, sensitivity, and positive predictive value of SNOMED CT. Of the 4996 problems in the test set, SNOMED CT correctly identified 4568 terms (true-positive results); 36 terms were true negatives, 9 terms were false positives, and 383 terms were false negatives. SNOMED CT had a sensitivity of 92.3%, a specificity of 80.0%, and a positive predictive value of 99.8%. SNOMED CT, when used as a compositional terminology, can exactly represent most (92.3%) of the terms used commonly in medical problem lists. Improvements to synonymy and adding missing modifiers would lead to greater coverage of common problem statements. Health care organizations should be encouraged and provided incentives to begin adopting SNOMED CT to drive their decision-support applications.

  11. Noninvasive Detection of AR-FL/AR-V7 as a Predictive Biomarker for Therapeutic Resistance in Men with Metastatic Castration-Resistant Prostate Cancer

    Science.gov (United States)

    2016-10-01

    Accomplishments 4 4. Impact 9 5. Changes /Problems 11 6. Products 12 7. Participants & Other Collaborating Organizations 15 8. Special Reporting...AWARD NUMBER: W81XWH-15-2-0052 TITLE: Noninvasive Detection of AR-FL/AR-V7 as a Predictive Biomarker for Therapeutic Resistance in Men with...Metastatic Castration- Resistant Prostate Cancer PRINCIPAL INVESTIGATOR: Stephen Plymate RECIPIENT: University of Washington Seattle, WA 98195

  12. Automatisierte Flüssigchromatographie mit Säulenschaltung und Ultraviolettspektroskopie oder Massenspektrometrie für therapeutisches Drug Monitoring von Antipsychotika und Antidepressiva

    OpenAIRE

    Sachse, Julia

    2005-01-01

    Therapeutisches Drug Monitoring (TDM) wird zur individuellen Dosiseinstellung genutzt, um die Effizienz der Medikamentenwirkung zu steigern und das Auftreten von Nebenwirkungen zu senken. Für das TDM von Antipsychotika und Antidepressiva besteht allerdings das Problem, dass es mehr als 50 Medikamente gibt. Ein TDM-Labor muss dementsprechend über 50 verschiedene Wirkstoffe und zusätzlich aktive Metaboliten messen. Mit der Flüssigchromatographie (LC oder HPLC) ist die Analyse vieler unterschied...

  13. Algunas novelas de Darío Fernández-Flórez: de Zarabanda (1944 a Alta Costura (1954. Temas escabrosos en tiempos de restricciones moralistas

    Directory of Open Access Journals (Sweden)

    Montejo Gurruchaga, Lucía

    2008-06-01

    Full Text Available Dario Fernández-Flórez begins in 1944 with Zarabanda a narrative style of intellectual eroticism and inmoral atmosphere which attracted no attention. Six years later he published Lola, espejo oscuro the recollections of a high prostitute. The novel was an scandal and an immediate success. Although the topic and its treatment were odd at the time because the strict moral values which mantained Franco´s regime were ignored, the novel was published with no cuts at all. Censorship was deaf to all the voices that warned of its dangers. This had an explanation: Darío Fernández-Flórez held an important post in the Propaganda National Service. After his dismissal censors were less lenient.Darío Fernández-Flórez inicia en 1944 con Zarabanda una narrativa de erotismo intelectualizado y ambiente amoral que no tuvo ningún eco. Seis años después publicará Lola, espejo oscuro, las memorias de una prostituta de alto copete. La novela suscitó un gran escándalo y su éxito fue inmediato. Aunque el tema y su tratamiento eran inusitados en aquellos momentos porque la obra daba al traste con los estrictos valores morales que sustentaban el régimen franquista, la novela fue publicada sin recortes; la censura hizo oídos sordos a todas las voces que alertaban de su peligro. Este hecho tiene una explicación: Darío Fernández-Flórez ocupaba un cargo importante en el Servicio Nacional de Propaganda. Tras su cese, los censores serán menos benevolentes.

  14. Optimization and validation of a fast amplification protocol for AmpFlSTR® Profiler Plus® for rapid forensic human identification.

    Science.gov (United States)

    Laurin, Nancy; Frégeau, Chantal

    2012-01-01

    The goal of this work was to optimize and validate a fast amplification protocol for the multiplex amplification of the STR loci included in AmpFlSTR(®) Profiler Plus(®) to expedite human DNA identification. By modifying the cycling conditions and by combining the use of a DNA polymerase optimized for high speed PCR (SpeedSTAR™ HS) and a more efficient thermal cycler instrument (Bio-RAD C1000™), we were able to reduce the amplification process from 4h to 26 min. No modification to the commercial AmpFlSTR(®) Profiler Plus(®) primer mix was required. When compared to the current Royal Canadian Mounted Police (RCMP) amplification protocol, no differences with regards to specificity, sensitivity, heterozygote peak height ratios and overall profile balance were noted. Moreover, complete concordance was obtained with profiles previously generated with the standard amplification protocol and minor alleles in mixture samples were reliably typed. An increase in n-4 stutter ratios (2.2% on average for all loci) was observed for profiles amplified with the fast protocol compared to the current procedure. Our results document the robustness of this rapid amplification protocol for STR profiling using the AmpFlSTR(®) Profiler Plus(®) primer set and demonstrate that comparable data can be obtained in substantially less time. This new approach could provide an alternative option to current multiplex STR typing amplification protocols in order to increase throughput or expedite time-sensitive cases.

  15. Demanda hídrica de la variedad de tomate Fl 5 en condiciones de organopónico

    Directory of Open Access Journals (Sweden)

    Melba Cabrera L.

    2004-01-01

    Full Text Available El objetivo de este trabajo fue determinar la demanda hídrica por fase de desarrollo de la variedad de tomate FL-5, en condiciones de organopónico, así como algunos aspectos de la fisiología del cultivo, lo cual contribuirá al desarrollo de una tecnología de riego, que es necesaria crear en los organopónicos y huertos intensivos. Esto permitirá hacer un manejo adecuado del riego, así como un uso mas eficiente del agua, lo que evidentemente proporcionará un ahorro del consumo del agua en nuestro país. Los experimentos se desarrollaron en, en condiciones de canaletas y los tratamientos de humedad fueron: 100, 85 y 50% de la Evapotranspiración (ETM . El sistema de riego localizado utilizado fue por goteros de 4l/h. La norma se determino por el método bioclimático (ETM= K x e. Se realizaron mediciones morfológicas y fonológicas en las plantas, y al final se evaluaron los índices de cosecha. Se determino el Contenido relativo de Agua CRA y el Potencial Osmótico (PO. Los resultados muestran los requerimientos hídricos por fase de desarrollo del cultivo, donde la mayor demanda ocurre para todos los tratamientos en el periodo de floración-fructificación. No se presentaron diferencias significativas en los rendimientos, entre los tratamientos de 100 y 85% de la ETM, pero ambos si difieren con el 50%

  16. Multibeam observations of mine burial near Clearwater, FL, including comparisons to predictions of wave-induced burial

    Science.gov (United States)

    Wolfson, M.L.; Naar, D.F.; Howd, P.A.; Locker, S.D.; Donahue, B.T.; Friedrichs, Carl T.; Trembanis, A.C.; Richardson, M.D.; Wever, T.F.

    2007-01-01

    A Kongsberg Simrad EM 3000 multibeam sonar (Kongsberg Simrad, Kongsberg, Norway) was used to conduct a set of six repeat high-resolution bathymetric surveys west of Indian Rocks Beach (IRB), just to the south of Clearwater, FL, between January and March 2003, to observe in situ scour and burial of instrumented inert mines and mine-like cylinders. Three closely located study sites were chosen: two fine-sand sites, a shallow one located in ??? 13 m of water depth and a deep site located in ???14 m of water depth; and a coarse-sand site in ???13 m. Results from these surveys indicate that mines deployed in fine sand are nearly buried within two months of deployment (i.e., they sunk 74.5% or more below the ambient seafloor depth). Mines deployed in coarse sand showed a lesser amount of scour, burying until they present roughly the same hydrodynamic roughness as the surrounding rippled bedforms. These data were also used to test the validity of the Virginia Institute of Marine Science (VIMS, Gloucester Point, VA) 2-D burial model. The model worked well in areas of fine sand, sufficiently predicting burial over the course of the experiment. In the area of coarse sand, the model greatly overpredicted the amount of burial. This is believed to be due to the presence of rippled bedforms around the mines, which affect local bottom morphodynamics and are not accounted for in the model, an issue currently being addressed by the modelers. This paper focuses specifically on two instrumented mines: an acoustic mine located in fine sand and an optical instrumented mine located in coarse sand. ?? 2007 IEEE.

  17. Concept Design of Trailor Ferry Service to Carry 150 Trailers Between Jacksonville, FL and Bridgeport, CT of USA

    Science.gov (United States)

    Sindagi, S. C.; Sandhu, B. S.

    2015-04-01

    With the increased load on highways, today there is a need to develop alternate ways to transport goods within the sovereignty. The use of ships to transport goods has always been the primary method of transporting goods across the seas but it can also be used to transport goods within the country. This way we can reduce the load on highways which at this point of time serve as the primary method of transportation. Worldwide very few ferries are in operation which transports 100-150 Trailers between two ports. Catching on this opportunity for design, construction and operation of vessels, a survey for possible routes in United States of America which will transport 150 Trailers has been conducted by various authorities and organizations. The challenge here is to determine the parameters of the vessel and design a fleet of vessels that could carry trailers along with their tractors within the least possible time and in with least possible freight between Jacksonville, FL and Bridgeport, CT of United States of America. The primary aim of the work presented here is to propose a design with fleet in such a way that each day 150 trailers could be loaded and unloaded at each of the two mentioned ports. An analysis of the route between the ports brought out various primary parameters like the distance, weather, different load lines to be encountered and also several size constraints that the vessel needs to adhere to, in order to ply smoothly on this route. The vessel is designed as per the Guidelines for ships operating in international waters. The economic analysis of the project was performed spanning over 20 years and the best freight was found out which would be most profitable for the company as well as be a good value for money for the customers.

  18. Assessment of estuarine water-quality indicators using MODIS medium-resolution bands: initial results from Tampa Bay, FL

    Science.gov (United States)

    Hu, Chuanmin; Chen, Zhiqiang; Clayton, Tonya D.; ,; Brock, John C.; Muller-Karger, Frank E.

    2004-01-01

    Using Tampa Bay, FL as an example, we explored the potential for using MODIS medium-resolution bands (250- and 500-m data at 469-, 555-, and 645-nm) for estuarine monitoring. Field surveys during 21–22 October 2003 showed that Tampa Bay has Case-II waters, in that for the salinity range of 24–32 psu, (a) chlorophyll concentration (11 to 23 mg m−3), (b) colored dissolved organic matter (CDOM) absorption coefficient at 400 nm (0.9 to 2.5 m−1), and (c) total suspended sediment concentration (TSS: 2 to 11 mg L−1) often do not co-vary. CDOM is the only constituent that showed a linear, inverse relationship with surface salinity, although the slope of the relationship changed with location within the bay. The MODIS medium-resolution bands, although designed for land use, are 4–5 times more sensitive than Landsat-7/ETM+ data and are comparable to or higher than those of CZCS. Several approaches were used to derive synoptic maps of water constituents from concurrent MODIS medium-resolution data. We found that application of various atmospheric-correction algorithms yielded no significant differences, due primarily to uncertainties in the sensor radiometric calibration and other sensor artifacts. However, where each scene could be groundtruthed, simple regressions between in situ observations of constituents and at-sensor radiances provided reasonable synoptic maps. We address the need for improvements of sensor calibration/characterization, atmospheric correction, and bio-optical algorithms to make operational and quantitative use of these medium-resolution bands.

  19. HYDROLOGY, LAKE COUNTY, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

  20. HYDROLOGY, GILCHRIST COUNTY, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

  1. Broward County, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  2. HYDRAULICS, OSCEOLA COUNTY, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  3. HYDRAULICS, LAKE COUNTY, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  4. HYDRAULICS, CITRUS COUNTY, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  5. SURVEY, CITRUS County, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Survey data includes spatial datasets and data tables necessary to digitally represent data collected in the survey phase of the study. (Source: FEMA Guidelines and...

  6. FL studio cookbook

    CERN Document Server

    Friedman, Shaun

    2014-01-01

    This book is built on recipes written in an easy-to-follow manner accompanied by diagrams and crucial insights and knowledge on what they mean in the real world. This book is ideal for musicians and producers who want to take their music creation skills to the next level, learn tips and tricks, and understand the key elements and nuances in building inspirational music. It's good to have some knowledge about music production, but if you have creativity and a good pair of ears, you are already ahead of the curve and well on your way.

  7. BASEMAP, JEFFERSON, FL, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  8. ORTHOIMAGERY, HIGHLANDS COUNTY, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Digital orthographic imagery datasets contain georeferenced images of the Earth's surface, collected by a sensor in which object displacement has been removed for...

  9. HYDRAULICS, LAKE COUNTY, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  10. HYDRAULICS, OSCEOLA COUNTY, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  11. HYDRAULICS, CLAY COUNTY, FL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  12. Mineralogía y termo-barometría de los Complejos máficos Sol de Mayo y Suya Taco, Norte de las Sierras de Comechingones, Córdoba Mineralogy and thermo-barometry of the Sol de Mayo and Suya Taco mafic complexes from northern Sierra de Comechingones, Córdoba

    Directory of Open Access Journals (Sweden)

    Alina M. Tibaldi

    2008-03-01

    the latter method may be not applicable to rocks crystallized from Fe-rich magmas. Amphibole-plagioclase thermometry estimates, which use typical core compositions, yield equilibrium temperature in the range of 750-850ºC. Whereas using rim compositions, Amph-pl thermometry estimates significantly give lower temperatures (< 600ºC, suggesting that amphiboles mostly crystallized at post-magmatic stages. Orthopyroxene-biotite Fe-Mg exchange thermometry shows that these minerals tend to equilibrate within two distinct thermal ranges (430-650ºC and 740-1030ºC. This indicates that biotites might have crystallized at both late-magmatic and post-magmatic stages. Barometric estimates have some variability in function of the type of calibration used, however they show a systematic pattern in which the equilibrium pressure determined in the Suya Taco complex are lower (5.5 ± 1 kbar than those obtained in the Sol de Mayo complex (8 ± 1 kbar. Overall, this result is consistent with barometry already performed in granulitic xenoliths. The P-T conditions deduced from igneous rocks indicate that the hosting regional metasedimentary sequence were experiencing amphibolite-facies temperatures and residing at middle crustal levels.

  13. Engagement für Flüchtlinge. Die Aufnahme vietnamesischer »Boat People« in der Bundesrepublik

    Directory of Open Access Journals (Sweden)

    Frank Bösch

    2017-03-01

    Full Text Available In the late 1970s, the Federal Republic of Germany witnessed a period of committed public outreach for Vietnamese refugees. While West Germany had not accepted significant numbers of non-European refugees before then, now tens of thousands of ›Boat People‹ rescued from the sea or flown out of camps found shelter as ›quota refugees‹. This article analyses the role civil society groups and political parties, media, and bureaucracy played in this. It shows that it was initially increasing public and international pressure that persuaded the social-liberal administration to accept refugees from Indochina, and that the concurrence of civic and state action subsequently reinforced the decision. Public pressure was created in large part by media campaigns and initiatives by Christian Democrats, who took a decisive stand in favour of taking in the refugees. A critical factor here was that the ›Boat People‹ were connected discursively with German post-war history. The article shows how refugee admission methods and new forms of humanitarian aid developed, both of which can be interpreted as civic and bureaucratic change. Rising xenophobia in the early 1980s eventually curbed this support. * * * In der Bundesrepublik entfaltete sich Ende der 1970er-Jahre eine engagierte Hilfe für Flüchtlinge aus Vietnam. Während Westdeutschland bis dahin kaum außereuropäische Flüchtlinge aufgenommen hatte, fanden nun mehrere zehntausend »Boat People« Schutz als »Kontingentflüchtlinge«, die im Meer gerettet und aus Lagern eingeflogen wurden. Der Aufsatz analysiert, welche Rolle dabei zivilgesellschaftliche Gruppen, politische Parteien, Medien und Bürokratie spielten. Anfangs bewegte vor allem öffentlicher und internationaler Druck die sozialliberale Regierung zur Aufnahme der Indochina-Flüchtlinge; später ergänzten sich zivilgesellschaftliches und staatliches Handeln aber wechselseitig. Der öffentliche Druck entstand insbesondere durch mediale

  14. Comparison between the amino acid, fatty acid, mineral and nutritional quality of raw, germinated and fermented African locust bean (Parkia biglobosa fl our

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    Oluwole Steve Ijarotimi

    2012-06-01

    Full Text Available Background. The most popular form of utilization of African locust bean (ALB is in its traditional fermentation food condiment (iru/dawadawa, which adds protein to a protein-poor diet and also as Medicine. In view of the nutritive values of ALB, the present study therefore aimed at investigating the effect of germination and fermentation on the nutritional quality of ALB fl our. Material and methods. The ALB was obtained from a local market in Akure, Nigeria. The seeds were divided into three portions, and treated as raw African locust bean (RALB, germinated African locust bean (GALB and fermented African locust bean (FALB respectively. Each of the samples was milled, sieved and analysed for chemical, functional properties and nutritional qualities using standard methods. Results. Some most important results of the chemical analysis were as follows: protein content range between 33.64 ±0.41 – 41.49 ±1.89 g/100 g, while the energy value was between 442.79 ±2.32 – 457.20 ±2.15 kcal. The P/Ca and Na/K ratio of the RALB were higher than other fl our samples respectively. Total essential amino acid was between 29.960-27.514 mg/100 g. Protein effi ciency ratio (PER was between 1.78-1.87; essential amino acid index 31.43-34.75%; while biological values were 22.56-26.18%. The dominant fatty acid (FA composition of the samples was linoleic with 33.687%, 31.578% and 28.7% for RALB, GALB and FALB respectively; while the least was lauric acid. The polyunsaturated/saturated FA ratio ranges between 0.589-0.718. The antinutrient concentration of fermented fl our sample was signifi cantly reduced than other food samples. Conclusion. The present study investigated the effect of germination and fermentation on the nutritional quality of ALB fl our. The fi nding showed that fermentation technique signifi cantly reduced antinutrient concentration and also improved the nutrient composition, particularly amino acid profi le of ALB fl our.

  15. tmunro_50m - swath bathymetry collected by the U.S. Geological Survey in Woods Hole, MA and St. Petersburg, FL offshore of the Gulf Islands, MS, 2010 (ESRI binary grid)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — In 2010, the U.S. Geological Survey in Woods Hole, MA and St. Petersburg, FL, in partnership with the U.S. Army Corps of Engineers, Mobile District conducted...

  16. tmunro_1m_bathycontours_MLLW.shp - 1-meter contours produced from swath bathymetry collected by the U.S. Geological Survey in Woods Hole, MA and St. Petersburg, FL offshore of the Gulf Islands, MS, 2010 (ESRI polyline shapefile)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — In 2010, the U.S. Geological Survey in Woods Hole, MA and St. Petersburg, FL, in partnership with the U.S. Army Corps of Engineers, Mobile District conducted...

  17. Current strategies for the prevention of breast cancer

    OpenAIRE

    Advani P; Moreno-Aspitia A

    2014-01-01

    Pooja Advani, Alvaro Moreno-AspitiaDepartment of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USAAbstract: Due to the high incidence of breast cancer in the United States, optimal strategies for its prevention are imperative. This entails identification of women who are at an increased risk for breast cancer and an integrative approach that includes effective screening methods as well as nutritional, pharmacologic, and surgical management. Several breast cancer risk-assessment tool...

  18. Pérdida de flúor en piezas dentarias permanentes expuestas a refrescos: estudio comparativo in vitro Fluor loss in permanent teeth exposed to beverages: Comparative study in vitro

    Directory of Open Access Journals (Sweden)

    P Núñez

    2006-04-01

    Full Text Available Introducción: La exposición a refrescos y zumos de frutas se encuentra en constante aumento, siendo su principal característica la elevada acidez que presentan. Con estas alteraciones del equilibrio oral, la perdida mineral de la estructura dentaria es muy frecuente. Nuestro objetivo fue identificar la cantidad de flúor perdido de una pieza dentaria y comparar el efecto de dos bebidas presentes en el mercado. Metodología: Se formaron dos grupos con 15 premolares cada uno, extraídos por indicación de ortodoncia; las piezas no presentaban patologías clínicas. El experimento consistió en la aplicación de un amortiguador de fuerza iónica para posteriormente llevarlo a una curva de calibración. Luego con un pH metro (ORION, modelo 920 A se obtuvo los datos de pH de las bebidas; luego, durante 30 minutos se sumergió en la respectiva bebida para que con el electrodo se obtuviera los resultados de flúor presente. Se realizo la prueba estadística T test para muestras independientes. Resultados: cada vez más estudios confirman el impacto de los ácidos en la cavidad oral y su papel en la erosión dentaria. En nuestro estudio se aprecio un pH de 3,1 para la bebida de naranja y 2,5 para la bebida cola. Además arrojo diferencia significativa de la pérdida de flúor según la bebida aplicada (pIntroduction: The exposure of soft drinks and fruit juices is constantly increasing and the main caracteristic of these beverages is the high acidity. This alteration of oral balance causes a more frequent loss of dental minerals. Our main objective was to identify the quantity loss of fluor of a tooth and compare this effect caused by two different kinds of soft drinks. Methodology: 30 bicuspids were put in two different groups, 15 in each, extracted by ortodontics indication The tooth did not have evidence of clinical pathology. The experiment consisted in applying an ionic buffer, and later put the results in a calibration curve. So with a p

  19. Comparative clinical and haematological investigations in lactating cows with subclinical and clinical ketosis

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    Vania Marutsova

    2015-10-01

    Full Text Available Ketosis of lactating cows is among the most common metabolic diseases in modern dairy farms. The economic importance of the disease is caused by the reduced milk yield and body weight loss, poor feed conversion, lower conception rates, culling and increased mortality of affected animals. In the present study, a total of 47 high-yielding dairy cows up to 45 days in milk (DIM are included. All animals were submitted to physical examination wich included checking the rectal body temperature, heart rate, respiratory and rumen contraction rates, and inspection of visible mucous coats. The body condition was scored, and blood β-hydroxybutyrate (BHBA concentrations were assayed. The cows were divided into 3 groups: first group (control (n=24 with blood β-hydroxybutyrate level 2.6 mmol/l (clinical ketosis. Whole blood samples were obtained and analyzed for Red Blood Cell (RBC, 1012/l, Hemoglobin (HGB, g/l, Hematocrit (HCT, %, Mean Corpuscular Volume (MCV, fl, Mean Corpuscular Hemoglobin (MCH, pg, Mean Corpuscular Hemoglobin Concentration (MCHC, g/l, White Blood Cell (WBC, 109/l, Lymphocytes (LYM, 109/l, Monocytes (MON, 109/l, Granulocytes (GRA, 109/l, Red Blood Distribution Width (RDW, %, Red Blood Cell Distribution Width Absolute (RDWa, fl, Platelets (PLT, 109/l and Mean Platelet Volume (MPV, fl. In this study, deviations in the clinical parameters in the control group and in those with subclinical ketosis were not identified. The cows from the third group (clinical ketosis exhibited hypotonia, anorexia and body weight loss vs. control group. Hematological analysis showed leukocytosis and lymphocytosis in cows with subclinical ketosis vs. control group. In cows with clinical ketosis WBC counts decreased (leukopenia, while hemoglobin content and hematocrit values are higher vs. control group. Blood BHBA values are higher in both groups of ketotic cows vs. the control group. The other analyzed parameters (RBC, MCH, MCHC, MCV, RDW, RDWa, MON, GRA, PLT

  20. Detection and characterization of silver nanoparticles and dissolved species of silver in culture medium and cells by AsFlFFF-UV-Vis-ICPMS: application to nanotoxicity tests.

    Science.gov (United States)

    Bolea, E; Jiménez-Lamana, J; Laborda, F; Abad-Álvaro, I; Bladé, C; Arola, L; Castillo, J R

    2014-03-07

    A methodology based on Asymmetric Flow Field-Flow Fractionation (AsFlFFF) coupled with UV-Vis absorption spectrometry and ICP mass spectrometry (ICPMS) has been developed and applied to the study of silver nanoparticles (AgNPs) and dissolved species of silver in culture media and cells used in cytotoxicity tests. The effect of a nano-silver based product (protein stabilized silver nanoparticles ca. 15 nm average diameter) on human hepatoma (HepG2) cell viability has been studied. UV-Vis absorption spectrometry provided information about the nature (organic vs. nanoparticle) of the eluted species, whereas the silver was monitored by ICPMS. A shift towards larger hydrodynamic diameters was observed in the AgNPs after a 24 hour incubation period in the culture medium, which suggests a "protein corona" effect. Silver(I) associated with proteins present in the culture medium has also been detected, as a consequence of the oxidation process experimented by the AgNPs. However, the Ag(I) released into the culture medium did not justify the toxicity levels observed. AgNPs associated with the cultured HepG2 cells were also identified by AsFlFFF, after applying a solubilisation process based on the use of tetramethylammonium hydroxide (TMAH) and Triton X-100. These results have been confirmed by transmission electronic microscopy (TEM) analysis of the fractions collected from the AsFlFFF. The effect of AgNPs on HepG2 cells has been compared to that caused by silver(I) as AgNO3 under the same conditions. The determination of the total content of silver in the cells confirms that a much larger mass of silver as AgNPs with respect to AgNO3 (16 to 1) is needed to observe a similar toxicity.

  1. "SUMAR Y NO SER SUMADOS": CULTURAS JUVENILES REVOLUCIONARIAS. MAYO DE 1968 Y DIVERSIFICACIÓNIDENTITARIA EN CHILE "To add but not to be added": Youth cultures Revolutionaries. May 1968 and identitary diversification in Chile

    Directory of Open Access Journals (Sweden)

    Yanko González

    2010-07-01

    Full Text Available El trabajo analiza y discute la génesis y diversificación identitaria de las y los jóvenes en Chile a partir de su articulación y secularización con los movimientos estudiantiles. Para ello se centra en algunos referentes que posibilitaron la emergencia de la juventud como sujeto y actor social, para llegar a la expansión y diversificación de las culturas juveniles en sincronía tanto con los procesos de reforma universitaria en el país (1967 como con el imaginario emancipatorio y juvenilizante emanado de la revolución de mayo de 1968 en Francia.This paper analyzes and discusses the genesis and the identity diversification of Chilean youth, starting from their articulation and secularization with regard to the student movements. In order to do so, it is centered in some referents that made possible the emergency of youth as subject and social actor, so as to arrive to the expansion and diversification of youth cultures in synchrony with the Chilean university reform (1967, and with the emancipationist and juvenilized imaginary that came along with the French revolution of May 68'.

  2. Ingestão de flúor por crianças pela água e dentifrício

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    Lima Ynara Bosco de Oliveira

    2001-01-01

    Full Text Available OBJETIVO: Determinar a dose total de flúor proporcionada por dieta (líquidos e sólidos e escovação com dentifrícios fluoretados a crianças na idade crítica para o desenvolvimento da fluorose dental em uma região de água fluoretada. MÉTODOS: Para realização de um estudo-piloto, foram selecionadas 39 crianças (20 a 30 meses de idade de uma creche de Piracicaba, SP, Brasil. Elas bebiam água fluoretada de abastecimento e comiam alimentos preparados com ela. Foi feita a coleta da dieta-duplicada e dos produtos da escovação por dois dias seguidos, em quatro períodos do ano. A concentração de flúor nas amostras foi determinada utilizando-se eletrodo específico. Foi realizada análise de variância (Anova com nível de 5% de significância. RESULTADOS: A dose total média encontrada foi de 0,090 mg F/dia/kg, tendo a dieta contribuído com 45%, e o dentifrício, com 55%. CONCLUSÕES: Aceitando-se o limite de 0,07 mg F/kg para exposição sistêmica ao flúor, conclui-se que as crianças estão expostas a uma dose total de risco em termos de fluorose dental clinicamente aceitável. Entre as várias medidas de precaução que poderiam ser tomadas para diminuir a ingestão de flúor, a redução da quantidade de dentifrício utilizada para escovar os dentes foi considerada a mais apropriada, contemplando risco/benefício para a saúde pública.

  3. Quercetin 3-O-methyl ether protects FL83B cells from copper induced oxidative stress through the PI3K/Akt and MAPK/Erk pathway

    Energy Technology Data Exchange (ETDEWEB)

    Tseng, Hsiao-Ling, E-mail: lily1001224@gmail.com [Department of Life Sciences, Tzu Chi University, Hualien, Taiwan (China); Li, Chia-Jung, E-mail: 97751101@stmail.tcu.edu.tw [Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan (China); Huang, Lin-Huang, E-mail: yg1236@yahoo.com.tw [School of Medicine, Institute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan (China); Chen, Chun-Yao, E-mail: cychen@mail.tcu.edu.tw [Department of Life Sciences, Tzu Chi University, Hualien, Taiwan (China); Tsai, Chun-Hao, E-mail: 100726105@stmail.tcu.edu.tw [Department of Life Sciences, Tzu Chi University, Hualien, Taiwan (China); Lin, Chun-Nan, E-mail: lincna@cc.kmu.edu.tw [Faculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan (China); Department of Biological Science and Technology, School of Medicine, China Medical University, Taichung, Taiwan (China); Hsu, Hsue-Yin, E-mail: hsueyin@mail.tcu.edu.tw [Department of Life Sciences, Tzu Chi University, Hualien, Taiwan (China)

    2012-10-01

    Quercetin is a bioflavonoid that exhibits several biological functions in vitro and in vivo. Quercetin 3-O-methyl ether (Q3) is a natural product reported to have pharmaceutical activities, including antioxidative and anticancer activities. However, little is known about the mechanism by which it protects cells from oxidative stress. This study was designed to investigate the mechanisms by which Q3 protects against Cu{sup 2+}-induced cytotoxicity. Exposure to Cu{sup 2+} resulted in the death of mouse liver FL83B cells, characterized by apparent apoptotic features, including DNA fragmentation and increased nuclear condensation. Q3 markedly suppressed Cu{sup 2+}-induced apoptosis and mitochondrial dysfunction, characterized by reduced mitochondrial membrane potential, caspase-3 activation, and PARP cleavage, in Cu{sup 2+}-exposed cells. The involvement of PI3K, Akt, Erk, FOXO3A, and Mn-superoxide dismutase (MnSOD) was shown to be critical to the survival of Q3-treated FL83B cells. The liver of both larval and adult zebrafish showed severe damage after exposure to Cu{sup 2+} at a concentration of 5 μM. Hepatic damage induced by Cu{sup 2+} was reduced by cotreatment with Q3. Survival of Cu{sup 2+}-exposed larval zebrafish was significantly increased by cotreatment with 15 μM Q3. Our results indicated that Cu{sup 2+}-induced apoptosis in FL83B cells occurred via the generation of ROS, upregulation and phosphorylation of Erk, overexpression of 14-3-3, inactivation of Akt, and the downregulation of FOXO3A and MnSOD. Hence, these results also demonstrated that Q3 plays a protective role against oxidative damage in zebrafish liver and remarked the potential of Q3 to be used as an antioxidant for hepatocytes. Highlights: ► Protective effects of Q3 on Cu{sup 2+}-induced oxidative stress in vitro and in vivo. ► Cu{sup 2+} induced apoptosis in FL83B cells via ROS and the activation of Erk. ► Q3 abolishes Cu{sup 2+}-induced apoptosis through the PI3K/Akt and MAPK

  4. Semantic characteristics of NLP-extracted concepts in clinical notes vs. biomedical literature.

    Science.gov (United States)

    Wu, Stephen; Liu, Hongfang

    2011-01-01

    Natural language processing (NLP) has become crucial in unlocking information stored in free text, from both clinical notes and biomedical literature. Clinical notes convey clinical information related to individual patient health care, while biomedical literature communicates scientific findings. This work focuses on semantic characterization of texts at an enterprise scale, comparing and contrasting the two domains and their NLP approaches. We analyzed the empirical distributional characteristics of NLP-discovered named entities in Mayo Clinic clinical notes from 2001-2010, and in the 2011 MetaMapped Medline Baseline. We give qualitative and quantitative measures of domain similarity and point to the feasibility of transferring resources and techniques. An important by-product for this study is the development of a weighted ontology for each domain, which gives distributional semantic information that may be used to improve NLP applications.

  5. Effect of Platelet-Rich Plasma (PRP versus Autologous Whole Blood on Pain and Function Improvement in Tennis Elbow: A Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Seyed Ahmad Raeissadat

    2014-01-01

    Full Text Available Background. Autologous whole blood and platelet-rich plasma (PRP have been both suggested to treat chronic tennis elbow. The aim of the present study was to compare the effects of PRP versus autologous whole blood local injection in chronic tennis elbow. Methods. Forty patients with tennis elbow were randomly divided into 2 groups. Group 1 was treated with a single injection of 2 mL of autologous PRP and group 2 with 2 mL of autologous blood. Tennis elbow strap, stretching, and strengthening exercises were administered for both groups during a 2-month followup. Pain and functional improvements were assessed using visual analog scale (VAS, modified Mayo Clinic performance index for the elbow, and pressure pain threshold (PPT at 0, 4, and 8 weeks. Results. All pain and functional variables including VAS, PPT, and Mayo scores improved significantly in both groups 4 weeks after injection. No statistically significant difference was noted between groups regarding pain scores in 4-week follow-up examination (P>0.05. At 8-week reevaluations, VAS and Mayo scores improved only in PRP group (P<0.05. Conclusion. PRP and autologous whole blood injections are both effective to treat chronic lateral epicondylitis. PRP might be slightly superior in 8-week followup. However, further studies are suggested to get definite conclusion.

  6. Clinical utility of varenicline for smokers with medical and psychiatric comorbidity

    Directory of Open Access Journals (Sweden)

    Jon O Ebbert

    2009-11-01

    Full Text Available Jon O Ebbert, Kirk D Wyatt, Ali Zirakzadeh, Michael V Burke, JT HaysMayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USAAbstract: Chronic obstructive pulmonary disease (COPD is a costly and deadly disease afflicting an estimated 210 million people and accounting for 5% of all global deaths. Exposure to cigarette smoke is the greatest risk factor for COPD in the developed world. Smoking cessation improves respiratory symptoms and lung function and reduces mortality among patients with COPD. Cigarette smokers with COPD and other co-morbid conditions such as cardiovascular disease and psychiatric illnesses should receive comprehensive tobacco treatment interventions incorporating efficacious pharmacotherapies. Varenicline, an α4β2 nicotinic acetylcholine receptor partial agonist, is the newest and most effective drug currently available to promote smoking cessation. In conjunction with behavioral interventions and clinical monitoring for potential side effects, varenicline offers great hope for reducing smoking-attributable death and disability.Keywords: smoking cessation, chronic obstructive pulmonary disease, varenicline

  7. Growth hormone receptor exon 3 isoforms may have no importance in the clinical setting of multiethnic Brazilian acromegaly patients.

    Science.gov (United States)

    de Oliveira Machado, Evelyn; Lima, Carlos Henrique Azeredo; Ogino, Liana Lumi; Kasuki, Leandro; Gadelha, Mônica R

    2016-08-01

    Acromegaly is associated with significant morbidity and increased mortality, but has a variable severity phenotype. The presence of the exon 3-deleted isoform of the growth hormone receptor (d3-GHR) may influence the disease phenotype and treatment outcomes, including the frequency of biochemical discordance after medical treatment. The objective of this study was to analyze the influence of the d3-GHR isoform on clinical and biochemical characteristics and in the treatment outcomes of Brazilian multiethnic acromegaly patients. We retrospectively analyzed our acromegaly outpatient clinic databank and collected demographic, clinical, biochemical and treatment outcome data from those patients who agreed to participate in the study. A blood sample was collected from all patients, the DNA was extracted and the GHR isoforms were evaluated by PCR, with the full length (fl)-GHR represented by a 935-bp fragment and the d3-GHR represented by a 532-bp fragment. A total of 121 patients were included. Fifty-six patients (46.3 %) were full-length homozygous (fl/fl), 48 (39.7 %) were heterozygous (fl/d3) and 17 (14.0 %) were d3-GHR homozygous (d3/d3). There was no difference between patients homozygous for the fl isoform and those harboring at least one d3-GHR allele in the demographic, clinical and biochemical data or in the treatment outcomes, including somatostatin receptor ligands (SRL) monotherapy, combination therapy with SRL and cabergoline and pegvisomant treatment. There was also no difference between the groups for the frequency of GH and IGF-I discordance after medical treatment. GHR exon 3 genotyping appears to have no clinical significance, at least in Brazilian acromegaly patients.

  8. Effect of light-emitting diode (LED) vs. fluorescent (FL) lighting on laying hens in aviary hen houses: Part 2 - Egg quality, shelf-life and lipid composition.

    Science.gov (United States)

    Long, H; Zhao, Y; Xin, H; Hansen, H; Ning, Z; Wang, T

    2016-01-01

    In this 60-wk study, egg quality, egg shelf-life, egg cholesterol content, total yolk lipids, and yolk fatty acid composition of eggs produced by Dekalb white laying hens in commercial aviary houses with either light-emitting diode (LED) or fluorescent (FL) lighting were compared. All parameters were measured at 27, 40, and 60 wk of age, except for egg shelf-life, which was compared at 50 wk of age. The results showed that, compared to the FL regimen, the LED regimen resulted in higher egg weight, albumen height, and albumen weight at 27 wk of age, thicker shells at 40 wk of age, but lower egg weight at 60 wk of age. Egg quality change was similar between the lighting regimens during the 62-d egg storage study, indicating that LED lighting did not influence egg shelf-life. Eggs from both lighting regimens had similar cholesterol content. However, cholesterol concentration of the yolk (15.9 to 21.0 mg cholesterol/g wet weight yolk) observed in this study was higher than that of United States Department of Agriculture (USDA) database (10.85 mg/g). No significant differences in total lipids or fatty acid composition of the yolks were detected between the two lighting regimens.

  9. Accumulation of FlAsH/Lumio Green in active mitochondria can be reversed by beta-mercaptoethanol for specific staining of tetracysteine-tagged proteins.

    Science.gov (United States)

    Langhorst, Matthias F; Genisyuerek, Selda; Stuermer, Claudia A O

    2006-06-01

    Recent advances in the field of small molecule labels for live cell imaging promise to overcome some of the limitations set by the size of fluorescent proteins. We tested the tetracysteine-biarsenical labeling system in live cell fluorescence microscopy of reggie-1/flotillin-2 in HeLa and N2a cells. In both cell types, the biarsenical staining reagent FlAsH/Lumio Green accumulated in active mitochondria and led to mitochondrial swelling. This is indicative of toxic side effects caused by arsenic, which should be considered when this labeling system is to be used in live cell imaging. Mitochondrial accumulation of FlAsH/Lumio Green was reversed by addition of low concentrations of thiol-containing reagents during labeling and a subsequent high stringency thiol wash. Both ethanedithiol and beta-mercaptoethanol proved to be effective. We therefore established a staining protocol using beta-mercaptoethanol as thiol binding site competitor resulting in a specific staining of tetracysteine-tagged reggie-1/flotillin-2 of adequate signal to noise ratio, so that the more toxic and inconvenient ethanedithiol could be avoided. Furthermore, we show that staining efficiency was greatly enhanced by introducing a second tetracysteine sequence in tandem.

  10. Evaluation of DNA Repair Function as a Predictor of Response in a Clinical Trial of PARP Inhibitor Monotherapy for Recurrent Ovarian Carcinoma

    Science.gov (United States)

    2015-10-01

    Award Number: W81XWH-­‐13-­‐1-­‐0485 TITLE: Evaluation of DNA Repair Function as a Predictor of Response in a Clinical Trial of PARP Inhibitor...UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Mayo Clinic and Foundation AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT...Biomarkers That Predict Response to PARP Inhibitors and Platinum.” Over the past 12 months we have i) completed validation of the immunohistochemical

  11. «God save us from more revolutions»: the Aranjuez Mutiny and the Dos de Mayo uprising in the light of Count Fernán Núñez’s widow | «Dios nos libre de más revoluciones»: el Motín de Aranjuez y el Dos de Mayo vistos por la condesa viuda de Fernán Núñez

    Directory of Open Access Journals (Sweden)

    Antonio Calvo Maturana

    2011-12-01

    Full Text Available This essay’s objective is to analyse a direct and unpublished testimony of the two biggest Spanish historical events of 1808: the Mutiny of Aranjuez and Dos de Mayo Uprising. With this purpose we present to the public a collection of letters written by Maria Esclavitud Sarmiento, Countess of Fernan Nuñez, and found in the French National Archives of Paris. In this lady’s correspondence we can appreciate the fears, the hopes and the speculations lived and suffered by the people from Madrid during this period. Thanks to this source we have access to the impressions of an eyewitness (a woman, something even more interesting and unusual who was in constant relation with the current situation, gathering news and rumours, sometimes already obsolete in the next letter because of the frenetic political situation. By her contacts with well-informed people (such as her son, the count of Fernan Nuñez, or members of government like Pedro Cevallos or Eusebio Bardaji, the widow countess offers interesting information about the most important figures and events of this year: Ferdinand VII (his rise to the throne and the preparation for his trip to Bayonne, Napoleon (his arrival to Spain and his recognition, or not, of the new king, Manuel Godoy (his imprisonment and his delivery to French authorities, Charles IV (the renounce of his claim and his posterior regret and Marie Louise of Parme (many rumours related to her dark legend. | El objetivo de este trabajo es ofrecer al lector un testimonio directo e inédito de lo acontecido en Madrid durante los dos grandes hitos históricos españoles de 1808: el Motín de Aranjuez y el Dos de Mayo. Para ello utilizaremos principalmente unas cartas de María Esclavitud Sarmiento, condesa viuda de Fernán Núñez, encontradas en los Archivos Nacionales de París. Esta dama de la alta nobleza reflejó en su correspondencia los miedos, esperanzas y especulaciones que asaltaron a la sociedad madrileña del momento. De

  12. Estudio epidemiológico y anatómico del Síndrome de iris flácido intraoperatorio en pacientes con tratamiento con bloqueantes alfa 1 adrenérgicos

    OpenAIRE

    2013-01-01

    El Síndrome de iris flácido intraoperatorio (IFIS), descrito por Chang y Campbell en 2005, acontece durante la microcirugía de cataratas mediante facoemulsificación ultrasónica en pacientes que están en tratamiento con bloqueantes alfa-1 adrenérgicos (bloq-alfa1A). Está compuesto por una triada clínica: iris flácido atónico que se ondula en respuesta a la irrigación intraocular propia de la fluídica perioperatoria, tendencia iridiana a prolapsarse hacia la punta del facoemulsificador y las in...

  13. Avaliação da liberação de flúor e da capacidade de recarga em diferentes cimentos de ionômero de vidro

    Directory of Open Access Journals (Sweden)

    Yasmine Mendes Pupo

    Full Text Available Objetivo Avaliar a liberação e a capacidade de recarga de flúor de diferentes cimentos de ionômero de vidro, durante a simulação de desafio cariogênico. Material e método Foram confeccionados 12 corpos de prova para cada grupo experimental, com cimentos de ionômero de vidro convencionais – Maxxion R (FGM, Ketac Molar EasyMix (3M ESPE; cimento de ionômero de vidro modificado por resina – Vitrebond (3M ESPE, e resina composta, Filtek™ Z350XT (3M ESPE, como controle negativo. Os corpos de prova foram imersos alternadamente em sistema de ciclagem de pH, permanecendo 6 horas na solução de desmineralização e 18 horas na de remineralização, sendo mantidos em estufa a 37°C. Liberação de flúor foi verificada 1, 2, 7 e 14 dias antes e após a recarga com flúor, com eletrodo específico acoplado ao aparelho analisador de pH/fluoretos, calibrado a cada medição com soluções de fluoreto de sódio a 1 e 10 ppm, preparadas com TISAB II. Para leitura, foi adicionado 0,5 mL da amostra a igual volume de TISAB II. Recarga foi realizada com flúor neutro 2% por 4 minutos nas amostras, lavadas e imersas novamente nas soluções do sistema de ciclagem de pH. Os dados foram submetidos à análise de variância e ao teste de Tukey (α=0,05. Resultado A liberação inicial de fluoreto (μgF/cm2 foi de 45,36; 37,49, e 26,35 para Maxxion R, Vitrebond e Ketac Molar EasyMix, respectivamente. Diferenças estatísticas significativas entre os materiais foram verificadas antes e após a recarga (p=0,001. Após a aplicação tópica de flúor, os cimentos de ionômero de vidro apresentaram capacidade de recarga de flúor. Conclusão Cimentos de ionômero de vidro avaliados foram capazes de liberar flúor em soluções de ciclagem de pH e podem recarregar flúor através da aplicação tópica.

  14. External Compression Headaches

    Science.gov (United States)

    ... If protective headwear, such as a sports or construction helmet, is necessary, make sure it fits properly ... shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. © 1998-2017 Mayo ...

  15. Interstitial Lung Disease

    Science.gov (United States)

    ... toxins. If you work in mining, farming or construction or for any reason are exposed to environmental ... shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. © 1998-2017 Mayo ...

  16. Utópicas cidades de nossas andanças: flânerie e amizade no acompanhamento terapêutico

    Directory of Open Access Journals (Sweden)

    Analice de Lima Palombini

    2009-08-01

    Full Text Available Com base na experiência do acompanhamento terapêutico como uma clínica sem muros, imersa na cidade, o artigo centra-se no tema da cidade nas suas relações com a subjetividade. Valendo-se das elaborações de Benjamin sobre a flânerie e a idéia da amizade como política, presente em Foucault e Derrida, o texto assinala a importância, para a consecução dessa clínica, de se tomar em consideração a cidade como polis, aberta ao encontro com a diferença e, portanto, território de conflitos e negociação. Assim, a cidade como polis é a utopia que a clínica do acompanhamento terapêutico busca ativar.

  17. Measurement of the Inclusive e{\\pm}p Scattering Cross Section at High Inelasticity y and of the Structure Function FL

    CERN Document Server

    Aaron, F D; Andreev, V; Backovic, S; Baghdasaryan, A; Baghdasaryan, S; Barrelet, E; Bartel, W; Behrend, O; Belov, P; Begzsuren, K; Belousov, A; Bizot, J C; Boudry, V; Bozovic-Jelisavcic, I; Bracinik, J; Brandt, G; Brinkmann, M; Brisson, V; Britzger, D; Bruncko, D; Bunyatyan, A; Buschhorn, G; Bylinkin, A; Bystritskaya, L; Campbell, A J; Cantun Avila, K B; Ceccopieri, F; Cerny, K; Cerny, V; Chekelian, V; Cholewa, A; Contreras, J G; Coughlan, J A; Cvach, J; Dainton, J B; Daum, K; Delcourt, B; Delvax, J; De Wolf, E A; Diaconu, C; Dobre, M; Dodonov, V; Dossanov, A; Dubak, A; Eckerlin, G; Egli, S; Eliseev, A; Elsen, E; Favart, L; Fedotov, A; Felst, R; Feltesse, J; Ferencei, J; Fischer, D J; Fleischer, M; Fomenko, A; Gabathuler, E; Gayler, J; Ghazaryan, S; Glazov, A; Goerlich, L; Gogitidze, N; Gouzevitch, M; Grab, C; Grebenyuk, A; Greenshaw, T; Grell, B R; Grindhammer, G; Habib, S; Haidt, D; Helebrant, C; Henderson, R C.W; Hennekemper, E; Henschel, H; Herbst, M; Herrera, G; Hildebrandt, M; Hiller, K H; Hoffmann, D; Horisberger, R; Hreus, T; Huber, F; Jacquet, M; Janssen, X; Jonsson, L; Jung, A W; Jung, H; Kapichine, M; Katzy, J; Kenyon, I R; Kiesling, C; Klein, M; Kleinwort, C; Kluge, T; Knutsson, A; Kogler, R; Kostka, P; Kraemer, M; Kretzschmar, J; Kruger, K; Kutak, K; Landon, M P.J; Lange, W; Lastovicka-Medin, G; Laycock, P; Lebedev, A; Lendermann, V; Levonian, S; Lipka, K; List, B; List, J; Loktionova, N; Lopez-Fernandez, R; Lubimov, V; Makankine, A; Malinovski, E; Marage, P; Martyn, H U; Maxfield, S J; Mehta, A; Meyer, A B; Meyer, H; Meyer, J; Mikocki, S; Milcewicz-Mika, I; Moreau, F; Morozov, A; Morris, J V; Mozer, M U; Mudrinic, M; Muller, K; Naumann, Th; Newman, P R; Niebuhr, C; Nikiforov, A; Nikitin, D; Nowak, G; Nowak, K; Olsson, J E; Osman, S; Ozerov, D; Pahl, P; Palichik, V; Panagoulias, I; Pandurovic, M; Papadopoulou, Th; Pascaud, C; Patel, G D; Perez, E; Petrukhin, A; Picuric, I; Piec, S; Pirumov, H; Pitzl, D; Placakyte, R; Pokorny, B; Polifka, R; Povh, B; Radescu, V; Raicevic, N; Ravdandorj, T; Reimer, P; Rizvi, E; Robmann, P; Roosen, R; Rostovtsev, A; Rotaru, M; Ruiz Tabasco, J E; Rusakov, S; Salek, D; Sankey, D P.C; Sauter, M; Sauvan, E; Schmitt, S; Schoeffel, L; Schoning, A; Schultz-Coulon, H C; Sefkow, F; Shtarkov, L N; Shushkevich, S; Sloan, T; Smiljanic, I; Soloviev, Y; Sopicki, P; South, D; Spaskov, V; Specka, A; Staykova, Z; Steder, M; Stella, B; Stoicea, G; Straumann, U; Sykora, T; Thompson, P D; Toll, T; Tran, T H; Traynor, D; Truol, P; Tsakov, I; Tseepeldorj, B; Tsurin, I; Turnau, J; Urban, K; Valkarova, A; Vallee, C; Van Mechelen, P; Vargas, A; Vazdik, Y; von den Driesch, M; Wegener, D; Wunsch, E; Zacek, J; Zalesak, J; Zhang, Z; Zhokin, A; Zohrabyan, H; Zomer, F

    2011-01-01

    A measurement is presented of the inclusive neutral current e\\pm p scattering cross section using data collected by the H1 experiment at HERA during the years 2003 to 2007 with proton beam energies Ep of 920, 575, and 460 GeV. The kinematic range of the measurement covers low absolute four-momentum transfers squared, 1.5 GeV2 < Q2 < 120 GeV2, small values of Bjorken x, 2.9 \\cdot 10-5 < x < 0.01, and extends to high inelasticity up to y = 0.85. The structure function FL is measured by combining the new results with previously published H1 data at Ep = 920 GeV and Ep = 820 GeV. The new measurements are used to test several phenomenological and QCD models applicable in this low Q2 and low x kinematic domain.

  18. Antibiotic-resistant organisms cultured from Atlantic bottlenose dolphins (Tursiops truncatus) inhabiting estuarine waters of Charleston, SC and Indian River Lagoon, FL.

    Science.gov (United States)

    Schaefer, Adam M; Goldstein, Juli D; Reif, John S; Fair, Patricia A; Bossart, Gregory D

    2009-03-01

    Bottlenose dolphins (Tursiops truncatus) from estuarine waters of Indian River Lagoon, FL (IRL) and Charleston, SC (CHS) were cultured to screen for microorganism colonization and to assess antibiotic sensitivity. Swabs (n = 909) were collected from the blowhole, gastric fluid, and feces of 171 individual dolphins The most frequently cultured organisms were Plesiomonas shigelloides (n = 161), Aeromonas hydrophila (n = 144), Escherichia coli (n = 85), and Pseudomonas fluorescens (n = 82). In descending frequency, organisms demonstrated resistance to erythromycin, ampicillin, and cephalothin. Human and animal pathogens resistant to antibiotics used in human and veterinary medicine were cultured. Escherichia coli (E. coli) more often was resistant in IRL dolphins. Three cases of methicillin-resistant Staphylococcus aureus (MRSA) were found at CHS. Emergence of antibiotic resistance is not confined to humans. Bottlenose dolphins may serve as sentinels for transfer of resistance from humans and animals or indicate that antibiotics are reaching the marine environment and causing resistance to emerge through selective pressure and genetic adaptation.

  19. Álvaro Flórez Estrada y la reconciliación entre España y América

    Directory of Open Access Journals (Sweden)

    Rafael Herrera Guillén

    2012-01-01

    Full Text Available Este artículo analiza la visión de Flórez Estrada acerca de las contemporáneas independencias que los territorios iberoamericanos estaban llevando a cabo respecto de la metrópoli española. En su obra, este ilustrado y liberal español, intentó desesperadamente construir un puente de comunicación entre ambas orillas hispánicas. Su tesis era que los territorios iberoamericanos terminarían siendo dominados por cualquier otro imperio, si abandonaban la unión al imperio español, y de este modo, no lograrían la independencia.

  20. Concordance study between the ParaDNA® Intelligence Test, a rapid DNA profiling assay, and a conventional STR typing kit (AmpFlSTR® SGM Plus®).

    Science.gov (United States)

    Ball, G; Dawnay, N; Stafford-Allen, B; Panasiuk, M; Rendell, P; Blackman, S; Duxbury, N; Wells, S

    2015-05-01

    The ParaDNA® Intelligence Test enables STR profiling directly from human biological samples and evidence items collected from crime scene in 75min. Designed for non-expert use this system allows DNA information to be available to investigators before it would typically be available from a laboratory. The ParaDNA Intelligence Test system amplifies D3S1358, D8S119, D16S539, D18S1358 and TH01 STR loci and the gender typing locus amelogenin and detects the alleles present with HyBeacon® probes. Individual DNA samples from 381 UK Caucasian individuals were analysed using AmpFlSTR® SGM Plus® and the ParaDNA Intelligence Test with the derived STR profiles compared. Here we describe the high level of concordance demonstrated between the two systems and discuss this with reference to allele frequencies and the discriminatory power offered by the ParaDNA Intelligence Test.

  1. Eficácia dos Lasers de Nd:YAG, GaAlAsE flúor gel No tratamento da hipersensibilidade dentinária.

    OpenAIRE

    Soares, Marília de Lima

    2013-01-01

    A hipersensibilidade dentinária (HD) é uma patologia caracterizada por uma dor odontogênica aguda, de curta duração e súbita. Apesar de sua alta prevalência, seu tratamento ainda não está bem estabelecido e recentemente os lasers tem se mostrado uma alternativa interessante. O objetivo deste estudo clínico de boca dividida (split-mouth), cego simples foi analisar a eficácia do laser de GaAlAs e o de Nd:YAG em comparação ao flúor gel tópico. Participaram do estudo 23 pacientes em um total de 8...

  2. Allele and haplotype distribution for 16 Y-STRs (AmpFlSTR Y-filer kit) in the state of Chihuahua at North Center of Mexico.

    Science.gov (United States)

    Gutiérrez-Alarcón, A B; Moguel-Torres, M; León-Jiménez, A K; Cuéllar-Nevárez, G E; Rangel-Villalobos, H

    2007-05-01

    The AmpFlSTR Y-filer kit, including 16 Y-STRs was analyzed in 326 males from Chihuahua, at North Central, Mexico. Allele frequencies and gene diversity for each locus were estimated. Four allele duplications, namely DYS389II, DYS390, DYS391 and DYS439; and one allele null at DYS448 were observed in the sample. The haplotype diversity was 99.97+/-0.3%. The AMOVA results, including a previous report from West of Mexico (Jalisco), showed that most of the genetic variability between these Mexican populations is attributable to intrapopulational differences (99.87%). This result supports a low-genetic differentiation between males from North and West regions of Mexico.

  3. Fluoride does not induce DNA breakage in Chinese hamster ovary cells in vitro Flúor não induz danos ao DNA em células de ovário de hamster chinês in vitro

    Directory of Open Access Journals (Sweden)

    Daniel Araki Ribeiro

    2004-09-01

    Full Text Available Fluoride has been widely used in dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury to genetic material. Genotoxicity tests represent an important part of cancer research to assess the risk of potential carcinogens. In the current study, the potential DNA damage associated with exposure to fluoride was assessed by the single cell gel (comet assay in vitro. Chinese hamster ovary cells were exposed to sodium fluoride (NaF at final concentration ranging from 7 to 100 µg/ml for 3 h, at 37°C. The results pointed out that NaF in all concentrations tested did not contribute to DNA damage as depicted by the mean tail moment and tail intensity. These findings are clinically important since they represent an important contribution to a correct evaluation of the potential health risk associated with the exposure to dental agents.O flúor tem sido amplamente usado na Odontologia, pois é um agente profilático efetivo e específico contra a cárie dentária. Entretanto, o flúor em excesso pode representar perigos à saúde humana, especialmente por causar agressão ao material genético. Testes de genotoxicidade representam uma importante parte da pesquisa do câncer para a avaliação de risco de possíveis carcinógenos. Neste presente estudo, danos ao DNA associados à exposição ao flúor foram avaliados pelo teste de células individualizadas em gel de agarose (teste do cometa in vitro. Células de ovário de hamster chinês foram expostas ao fluoreto de sódio (NaF nas concentrações finais de 7 a 100 µg/ml, durante 3 h, a 37°C. Os resultados mostraram que o NaF não contribuiu para os danos no DNA em todas as concentrações testadas, conforme demonstrado pelas médias do momento da cauda e da intensidade da cauda dos cometas. Esses achados são clinicamente importantes, uma vez que representam uma importante contribui

  4. Expansion of CD34+ cells from human umbilical cord blood by FL and/or TPO gene transfected human marrow stromal cell lines

    Institute of Scientific and Technical Information of China (English)

    张毅; 唐佩弦; 金滢; 李秀森; 张双喜; 吴英; 毛宁

    2001-01-01

    To elucidate the effect of gene transfected marrow stromal cell on expansion of human cord blood CD34+ cells, a culture system was established in which FL and TPO genes were transfected into human stromal cell line HFCL. To establish gene transfected stromal cells co-culture system, cord blood CD34+ cells were purified by using a magnetic beads sorting system. The number of all cells and the number of CD34+ cells and CFC (CFU-GM and BFU-E) were counted in different culture systems. The results showed that in all 8 culture systems, SCF+IL-3+HFT manifested the most potent combination, with the number of total nucleated cells increasing by (893.3±52.1)-fold, total progenitor cells (CFC) by (74.5±5.2)-fold and CD34+ cells by 15.7-fold.Maximal expansions of CFC and CD34+ cells were observed at the end of the second week of culture. Within 14 days of culture, (78.1 ± 5.5)-fold and (57.0 ± 19.7)-fold increases in CFU-GM and BFU-E were obtained. Moreover, generation of LTC-IC from amplified CD34+ cells within 28 days was found only in two combinations, I.e. SCF+IL-3+FL+TPO and SCF+IL-3+HFT, and there was no significant difference between these two groups statistically. These results suggest that human umbilical cord blood CD34+ cells can be extensively expanded ex vivo by using gene transfected stromal cells along with cytokines.

  5. Prevenção da cárie dental com aplicações tópicas semestrais de flúor-fosfato acidulado

    Directory of Open Access Journals (Sweden)

    Pinto Ilza Leite

    1993-01-01

    Full Text Available Foram analisados os resultados preventivos da aplicação tópica semestral de gel com flúor-fosfato acidulado em 998 crianças, de 6, 8 e 10 anos, provenientes de famílias de baixa renda. Utilizou-se a metodologia de aplicação em massa sem profilaxia prévia desenvolvida no contexto do Programa Nacional de Prevenção da Cárie Dental. Após um ano, constatou-se em localidades sem fluoretação da água de consumo público redução na incidência de cárie da ordem de 31,6% em crianças de 6 anos, 24,9% aos 8 anos e 39,5% aos 10 anos, segundo o índice CPO-S. Nas localidades com flúor na água, as reduções foram, respectivamente, de 24,3%, 26,6% e 27,7%, em todos os casos com significância estatística ao nível de 95%. Face aos resultados positivos e à segurança, custo reduzido e praticidade do método, recomenda-se que os programas de saúde bucal em todos os níveis desenvolvam ação preventiva permanente, abrangente e sem solução de continuidade para as crianças sob sua responsabilidade.

  6. O flúor tópico na redução da cárie dental em adolescentes de Salvador - BA, 1996

    Directory of Open Access Journals (Sweden)

    CANGUSSU Maria Cristina Teixeira

    2001-01-01

    Full Text Available Os objetivos deste trabalho foram: descrever a experiência de cárie dental em adolescentes de 12 a 20 anos de Salvador - BA e testar a associação entre a severidade da cárie e o uso do flúor tópico na forma de gel ou bochechos. Realizou-se um estudo transversal e análise de regressão logística não condicional, pelo método "backward", com uma amostra de 493 adolescentes escolares do Distrito Sanitário Barra-Rio Vermelho. As variáveis de desenho foram obtidas a partir de questionário semi-estruturado e exame bucal. O CPOD correspondeu a 4,44 (DP 3,71, sendo de 2,72 (DP 2,75 aos 12-13 anos. Cento e quarenta e quatro adolescentes participaram de ações de promoção de saúde bucal (30% e a maioria declarou-se pouco apta a manter a própria saúde oral. O flúor tópico não se mostrou como um fator de proteção significativo na redução da cárie dental nesta população (RP = 0,9. Houve redução dos índices de cárie dental nos adolescentes do Distrito, embora exista a necessidade de reformulação do modelo cirúrgico-restaurador de atenção à saúde bucal, para maior controle da cárie dental e melhor efetividade dos métodos de promoção e proteção à saúde bucal.

  7. El mundo del libro : mayo de 1969

    Directory of Open Access Journals (Sweden)

    Agustín Rodríguez Garavito

    1969-05-01

    Full Text Available Se presentan las reseñas de los siguientes títulos: SITIOS, SUCESOS, PERSONAJES CARAQUEÑOS-Por Héctor Parra Márquez-Caracas. Venezuela. THESAURUS-Boletín del Instituto Caro y Cuervo-Bogotá-Colombia. HISTORIA DE LA ETERNIDAD-Por Jorge Luis Borges-Buenos Aires-Argentina. MINERVA EN LA RUECA-Por Jorge Zalamea.

  8. El mundo del libro: Mayo de 1959

    Directory of Open Access Journals (Sweden)

    Agustín Rodríguez Garavito

    1959-05-01

    Full Text Available Se presentan las reseñas de las siguientes obras y autores: Un campesino sin regreso / Euclides Jaramillo Arango. La estación violenta / Octavio Paz La casimba / Isaac López Freyre Sonetos del amor y de la muerte / Carlos Castro Saavedra El Girasol / Eduardo Santa Los Estados Unidos mito y realidad. Obra inducida / Ricardo Alvarado La vida literaria en la edad media / Gustavo Cohen Se llamaba Bolívar... / Enrique Campos Méndez Cuentos impresionantes / Alfonso Bonilla Naar

  9. Sacred Heart Hospital, Pontoon Road, Castlebar, Mayo.

    LENUS (Irish Health Repository)

    Sorensen, Kristine

    2012-01-25

    Abstract Background Health literacy concerns the knowledge and competences of persons to meet the complex demands of health in modern society. Although its importance is increasingly recognised, there is no consensus about the definition of health literacy or about its conceptual dimensions, which limits the possibilities for measurement and comparison. The aim of the study is to review definitions and models on health literacy to develop an integrated definition and conceptual model capturing the most comprehensive evidence-based dimensions of health literacy. Methods A systematic literature review was performed to identify definitions and conceptual frameworks of health literacy. A content analysis of the definitions and conceptual frameworks was carried out to identify the central dimensions of health literacy and develop an integrated model. Results The review resulted in 17 definitions of health literacy and 12 conceptual models. Based on the content analysis, an integrative conceptual model was developed containing 12 dimensions referring to the knowledge, motivation and competencies of accessing, understanding, appraising and applying health-related information within the healthcare, disease prevention and health promotion setting, respectively. Conclusions Based upon this review, a model is proposed integrating medical and public health views of health literacy. The model can serve as a basis for developing health literacy enhancing interventions and provide a conceptual basis for the development and validation of measurement tools, capturing the different dimensions of health literacy within the healthcare, disease prevention and health promotion settings.

  10. Dos cuentecillos de invierno: Creciente de mayo

    Directory of Open Access Journals (Sweden)

    Adel López Gómez

    1965-04-01

    Full Text Available Provistos de sus largas sogas, los hombres habían bajado del poblado ribereño para enlazar los maderos al paso de la brava corriente. Había cuajado apenas la limpieza del amanecer invernal, pero el aire trémulo, en aquella áspera cuenca del río Cauca, conservaba ese último toque de noche que le da al día sobre la tierra su primera virginidad elemental.

  11. El mundo del libro: mayo de 1963

    Directory of Open Access Journals (Sweden)

    Agustín Rodríguez Garavito

    1963-05-01

    Full Text Available El documento presenta las reseñas de los siguientes títutlos: Huellas -Por Luis Ernesto Puyana. Bucaramanga, Colombia. Panorama del Folklore Venezolano. Biblioteca de Cultura Universitaria - Caracas. Vitral de Bruma. Helvia de Bodmer. Editorial Antares. Bogotá. Una introducción al arte. F. Gil Tovar. La Mala Hora. Gabriel García Márquez. Premio Literario ESSO. 1961. Camus el Justo. C. Hourdin. Editorial Estela. Barcelona, España. Don Antonio Nariño. Fernando Galvis Salazar. -Drama en once cuadros. Bogotá, Colombia.

  12. El mundo del libro: Mayo de 1961

    Directory of Open Access Journals (Sweden)

    Agustín Rodríguez Garavito

    1961-05-01

    Full Text Available Se presentan las reseñas de las siguientes obras y autores: Introducción a la sociología o itinerario para una filosofía de lo social; Bernal Jimenez, Rafael. Mis Respetables jefes; Zacs, Vera. Arte Colombiano; Revista Lampara. Rudimentos de onomatología; Luis López de Mesa. Galería y romance de la historia; Montezuma Hurtado, Alberto. Yanguaro; Vargas, Luis Hernando. Campesinos de los Andes; Fals Borda, Orlando.

  13. El mundo del libro: Mayo de 1967

    Directory of Open Access Journals (Sweden)

    Agustín Rodríguez Garavito

    1967-05-01

    Full Text Available -La subversión en Colombia. Por Orlando Fals Borda. Universidad Nacional. Ediciones Tercer Mundo. Bogotá. Colombia -La educación del adolescente. Por Gabriel Anzola Gómez. Editorial Norma. Cali. Colombia -Conversando... Por Laureano García Ortiz. Biblioteca de Historia Nacional. Volumen CIX. Bogotá. Colombia -El signo. Poesías. Por Lucía Vergara Díaz. Editorial PAX. Bogotá -Poemas italianos. Por Néstor Madrid Malo. Editorial Antares. Tercer Mundo. Bogotá. Colombia -Lágrimas del día. Poemas. Segunda edición. Por Rafael Naranjo Balcázar. Medellín, Colombia

  14. El mundo del libro: Mayo de 1966

    Directory of Open Access Journals (Sweden)

    Agustín Rodríguez Garavito

    1966-05-01

    Full Text Available -DIARIO. Por Hernando Téllez. -DIAS DE BELLO EN CARACAS. Por Héctor Parra Márquez- Italigráfica. Caracas. -CON LOS POBRES DE AMÉRICA. Pensamiento político de Tomic, Montoro, Cornejo, Caldera y Frei. -ACTUALIDADES "ECOPETROL". Publicaciones de Relaciones de ECOPETROL. -REMINISCENCIAS DE SANTAFE Y BOGOTÄ. Por José María Cordovez Moure, Biblioteca Shering. Bogotá. Colombia. -EL ESTADO FUERTE. Por Alfonso López Michelsen, Ediciones Populibro. -LA EDUCACIÓN EN COLOMBIA. Por Alejandro Bernal Escobar, Andrés Benoit, Bertha Corredor e Isaac Wust. Oficina Internacional de Investigaciones Sociales de FERE-Lovaina-Bélgica. -LA PICUA SE VA. Por Lucy Barco de Valderrama. Ediciones Lerner.

  15. Ave Maria Nursing Home, Tooreen, Ballyhaunis, Mayo.

    LENUS (Irish Health Repository)

    Kane, Bridget

    2009-08-01

    This paper provides an analysis of the collaborative work conducted at a multidisciplinary medical team meeting, where a patient’s definitive diagnosis is agreed, by consensus. The features that distinguish this process of diagnostic work by consensus are examined in depth. The current use of technology to support this collaborative activity is described, and experienced deficiencies are identified. Emphasis is placed on the visual and perceptual difficulty for individual specialities in making interpretations, and on how, through collaboration in discussion, definitive diagnosis is actually achieved. The challenge for providing adequate support for the multidisciplinary team at their meeting is outlined, given the multifaceted nature of the setting, i.e. patient management, educational, organizational and social functions, that need to be satisfied.

  16. El mundo del libro: mayo de 1979

    Directory of Open Access Journals (Sweden)

    Agustín Rodríguez Garavito

    1979-05-01

    Full Text Available En el documento se presentan las reseñas de los siguientes títulos: -Cayetano Betancur. Manual del ciudadano. Brevarios Colombianos. Ediciones del Banco de la República. -Alberto Duarte French. Guía practica del derecho de familia. Editorial Temis. Librería. 1978. -Abel Naranjo Villegas. Generaciones colombianas. Brevarios Colombianos. Ediciones Banco de la República. Artes Gráficas Centro Don Bosco. -Flor Alba Uribe Marin. Historia de la pequeña Nubia y su Mercenaria virginidad. Ediciones Tercer mundo. Bogotá, Colombia. -Abelardo Forero Benavides. El siglo XIX. Galería de sombras. Nariño, Bolívar, Santander, Obando, Mosquera, Nuñez. Fundación Centenario del Banco de Colombia. 1978. Impreso por Litoformas de Colombia. -Luis Duque Gómez. Introducción al pasado aborigen. Brevarios Colombianos. Banco de la República. Talleres Editorial Retina. Bogotá. Colombia. -Dibujos de Sergio Trujillo Magnenat. Texto de Germán Rubiano Caballero. Biblioteca Fundación Centenario del Banco de Colombia. -Mauro Torres. Tensión en la Unidad familiar. Padres e hijos. Edición Tercer Mundo. Bogotá, Colombia. -Ciro Medina. Antología. Editado por el Banco de América Latina. Impreso por Publicaciones Cultural Ltda. Bogotá, Colombia.

  17. El mundo del libro: mayo de 1964

    Directory of Open Access Journals (Sweden)

    Agustín Rodríguez Garavito

    1964-05-01

    Full Text Available EL documento presenta las reseñas de los siguientes titulos: Los Ratones Van al Infireno. Gonzalo Arango - Ediciones Tercer Mundo. Bogotá, Colombia. La Administración Pública en los Países en Desarrollo. Ediciones de la ESAP. Bogotá, Colombia. Colombia en Cifras. Plinio Mendoza Neira. - Talleres Gráficos AEDITA. Bogotá, Colombia. Colombia en la Hora Cero. Alfonso López Michelsen. - Ediciones Tercer Mundo. Bogotá, Colombia. Catalina. Elisa Mújica.-Novela- Editorial Aguilar. Madrid.

  18. El mundo del libro: mayo de 1962

    National Research Council Canada - National Science Library

    Agustín Rodríguez Garavito

    1962-01-01

    .... - Ensayo de metodología. • Si Mañana Despierto. Por Jorge Gaitán Durán. - Ediciones MITO. Bogotá, D. E. • Rafael Uribe Uribe. Por: Eduardo Santa. • Mientras Agonizo... Por William Faulkner...

  19. El mundo del libro: mayo de 1965

    Directory of Open Access Journals (Sweden)

    Agustín Rodríguez Garavito

    1965-05-01

    Full Text Available El documento presenta las reseñas de los siguientes títulos: Memorias infantiles- E. Caballero Calderón - Editorial Bedout. Medellín. El Aire y las Colinas- Poemas- Carlos Medellín- Bogotá-Colombia. Crepúsculo y albas- Poemas- Silverio Blanco Gutiérrez- Editorial "Canal Ramírez". Bogotá. El padre las causas-su doble personalidad- Biografía- Ramón Menéndez Pidal- Espasa-Calpe. Madrid.

  20. Claremount Nursing Home, Claremount, Claremorris, Mayo.

    LENUS (Irish Health Repository)

    2011-08-30

    Abstract Before a probiotic bacterium can even begin to fulfill its biological role, it must survive a battery of environmental stresses imposed during food processing and passage through the gastrointestinal tract (GIT). Food processing stresses include extremes in temperature, as well as osmotic, oxidative and food matrix stresses. Passage through the GIT is a hazardous journey for any bacteria with deleterious lows in pH encountered in the stomach to the detergent-like properties of bile in the duodenum. However, bacteria are equipped with an array of defense mechanisms to counteract intracellular damage or to enhance the robustness of the cell to withstand lethal external environments. Understanding these mechanisms in probiotic bacteria and indeed other bacterial groups has resulted in the development of a molecular toolbox to augment the technological and gastrointestinal performance of probiotics. This has been greatly aided by studies which examine the global cellular responses to stress highlighting distinct regulatory networks and which also identify novel mechanisms used by cells to cope with hazardous environments. This review highlights the latest studies which have exploited the bacterial stress response with a view to producing next-generation probiotic cultures and highlights the significance of studies which view the global bacterial stress response from an integrative systems biology perspective.

  1. Fusarium keratitis in Brazil: genotyping, in vitro susceptibilities, and clinical outcomes

    OpenAIRE

    2013-01-01

    Rafael A Oechsler,1 Tiago M Yamanaka,1 Paulo JM Bispo,1 Juliana Sartori,1 Maria Cecilia Zorat Yu,1 Analy Salles A Melo,2 Darlene Miller,3 Ana Luisa Hofling-Lima1 1Ophthalmology Department, 2Division of Infectious Diseases, Internal Medicine Department, Federal University of São Paulo, São Paulo, Brazil; 3Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA Background: The purpose of this paper is to describe clinical characteristic...

  2. Stemcell Information: SKIP000917 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available formation ... Tayaramma Thatava Tayaramma Thatava Department of Molecular Medicine, Mayo Clinic Department... of Molecular Medicine, Mayo Clinic ... Information Only Department of M...olecular Medicine, Mayo Clinic Department of Molecular Medicine, Mayo Clinic ... 22142803 10.1186/scrt89 Su

  3. CONFIGURACIÓN DEL FLÂNEUR EN POETA EN NUEVA YORK DE F. GARCÍA LORCA Configuration of the Flâneur in Poeta en Nueva York by F. García Lorca

    Directory of Open Access Journals (Sweden)

    René Araya Alarcón

    2012-07-01

    Full Text Available En primer término se analiza brevemente el contexto que posibilita en García Lorca la búsqueda de un nuevo lenguaje poético durante su estadía en Nueva York entre 1929-1930. Posteriormente se analiza el concepto de flâneur. Para ello se consideran las elaboraciones que desarrolló Walter Benjamin a propósito de la experiencia de Charles Baudelaire frente a las transformaciones urbanas y sociales que sufrió París a mediados del siglo XIX, durante el Segundo Imperio en Francia. Finalmente se indaga en la eventual configuración de la figura del flâneur en Poeta en Nueva York de Federico Garcia Lorca.First of all, it’s analyzed briefly the context that makes possible in García Lorca the search of a new poetic language during his stay in New York between 1929 and 1930. Subsequently it’s analyzed the concept of flâneur. Because of that, it must be taken into account the devise that Walter Benjamin explained according to Charles Baudelaire’s experience against the urban and social transformations that hit Paris in the 19th century during the Second French Empire. Finally it makes inquiries in the possible configuration of the flâneur in Poeta en Nueva York by Federico García Lorca.

  4. Alberto Flórez Malagón. “Una isla en un mar de sangre”. El Valle de Ubaté durante “La Violencia”, 1946-1958

    National Research Council Canada - National Science Library

    íngrid Bolívar

    2010-01-01

    ... Flórez Malagón a propósito de las relaciones entre las formas de poder y cultura local, el bipartidismo y las instituciones estatales en la sociedad campesina de Ubaté durante “La Violencia”. El autor señala que se interesó...

  5. Avaliação in vitro da liberação e da recarga de flúor em cimentos de ionômero de vidro

    Directory of Open Access Journals (Sweden)

    Evelyn Lopez Leite

    Full Text Available OBJETIVO: Este estudo avaliou a absorção de íons flúor em cimentos de ionômero de vidro de manipulação mecânica e manual, por uma única aplicação tópica de flúor. METODOLOGIA: Os cimentos de ionômeros de vidro (CIVs Riva Self Cure® (RSC-SDI e Ketac Molar Easymix® (KME- 3M-ESPE foram testados com um material controle (RC-resina composta ICE-SDI, após preparo de dez corpos de prova de cada um (n = 30. Esses corpos foram pesados e armazenados em água deionizada para as aferições da liberação de flúor (eletrodo específico, Orion 9606-BN em dois períodos: antes (PI: 1, 2, 7 e 14 dias e após aplicação tópica de flúor (PII: 16, 17, 18, 20, 22, 24, 26, 28 e 30 dias. No 15.º dia, cinco espécimes de cada material (n = 15 foram submetidos à aplicação tópica de fluoreto de sódio neutro a 2% ou de gel placebo de Natrosol (n = 15. RESULTADO: A maior liberação de íons flúor para ambos os CIVs ocorreu no primeiro dia do PI (KME = 13,44 ± 6,05; RSC = 6,88 ± 0,62 e a quantidade liberada foi semelhante no PII (KME = 6,22 ± 0,80; RSC = 6,67 ± 1,63. A comparação entre os períodos mostrou diferença significante somente para o KME, com maior liberação de flúor no PI (p 0,05. A análise de variância e o teste de Tukey (p < 0,05 não indicaram diferenças significantes entre os materiais antes e após a recarga. CONCLUSÃO: Os CIVs de manipulação mecânica ou manual possuem habilidade semelhante para captar íons flúor, quando submetidos a uma única aplicação tópica de fluoreto de sódio a 2%.

  6. Leopoldo Fortunato Galtieri ante la Plaza de Mayo el 2 de abril de 1982 : Desafía a Gran Bretaña por la soberanía en las Islas Malvinas y exhibe apoyo regional en la iniciativa bélica

    OpenAIRE

    Galtieri, Leopoldo Fortunato

    1982-01-01

    El presidente de facto, tras haber anunciado el desembarco militar en las Islas Malvinas para disputar la soberanía a Gran Gran Bretaña, se dirige al público reunido en la Plaza de Mayo. Ante lo que él llama "cabildo abierto", desafía al gobierno británico, y exhibe apoyo de países de nuestra región en el emprendimiento bélico. En este discurso pronuncia su conocida frase "si quieren venir que vengan, les presentaremos batalla". Culmina convocando a entonar el Himno Nacional Argentino. Leo...

  7. La salud bucal en los jóvenes de la corporación de residencias universitarias 10 de mayo: una aproximación desde la determinación social con énfasis en pertenencia étnica

    OpenAIRE

    Shirley Andrade Benavides; Santiago Chamorro Guerrero; Mileidy Agreda Yela; Sirena Porras Serrano

    2012-01-01

    Objetivo: Investigar la determinación social de la salud bucal de los estudiantes universitarios pertenecientes a comunidades indígenas y afrocolombianos del sur occidente del país, domiciliarios de las Residencias Universitarias 10 de Mayo. Métodos: Se realizo un estudio descriptivo con apoyo en una encuesta individual fundamentada en la Determinación Social, DS. Resultados: La mayor parte de la población es de género femenino y presenta mejor salud bucal que los hombres. Esto se explica por...

  8. Relación del Nivel de Conocimiento y Práctica de Higiene de las Madres en la Preparación de Alimentos en los Comedores Populares de los Centros Poblados Menores Miguel Grau y Nueva Alianza, Durante el Período de Mayo- Agosto, 2008.

    OpenAIRE

    Jara Pilco, Cinthia Esperanza; Huamán Villanueva, Elena Ruth

    2009-01-01

    Objetivo. Determinar la relación del nivel de conocimiento y la práctica de higiene de las madres en la preparación de alimentos en los comedores populares del centro poblado Miguel Grau y Nueva Alianza, durante los meses mayo y agosto del año 2008. Metodología. El estudio de la investigación fue correlacional transversal; la muestra estuvo conformada por 35 madres a quienes se aplicó dos instrumentos: una encuesta para determinar el nivel de conocimiento y una guía de observación para determ...

  9. Estrategia didáctica sustentada en la teoría de las relaciones humanas de Elton Mayo, para mejorar los niveles de relaciones interpersonales de los docentes del nivel primario de la escuela profesional de Educación de la Universidad Nacional "Pedro Ruiz Gallo", Lambayeque, año 2011.

    OpenAIRE

    Diaz Pita, Omar.

    2015-01-01

    La presente investigación tiene como objetivo Diseñar una Estrategia Didáctica para mejorar las relaciones interpersonales de los Docentes de la Escuela Profesional de Educación, Nivel Primario, de la Universidad Nacional "Pedro Ruiz Gallo" de Lambayeque. Para ello se aplicó una guía de observación, encuestas, entrevistas y testimonios. Luego de haber terminado esta parte se procedió a examinar el problema a la luz de la Teoría de las Relaciones Humanas de Elton Mayo y la Teoría de las Técnic...

  10. Seguimiento domiciliario a la madre adolescente y su recién nacido durante el puerperio. Hospital de Engativá ESE II nivel. Marzo – Mayo de 2009 / Household monitoring to the teen mother and her newborn during the postpartum period. Engativá hospital E.S.E II level March - May 2009

    OpenAIRE

    Rocha Velásquez , Vivian Gisell; Puentes López, Miguel Antonio

    2009-01-01

    El trabajo: “SEGUIMIENTO DOMICILIARIO A LA MADRE ADOLESCENTE Y SU RECIÉN NACIDO DURANTE EL PUERPERIO. HOSPITAL DE ENGATIVÁ ESE II NIVEL. MARZO – MAYO DE 2009”, es una estrategia del cuidado de enfermería, para identificar y evaluar riesgos y signos de alarma permitiendo planear y ejecutar intervenciones en el hogar apoyando a madres adolescentes en la recuperación de su salud, el aprendizaje en la crianza de sus hijos con el apoyo de la familia, identificando los riesgos tempranamente que pue...

  11. Liberação de flúor de cimentos ortodônticos antes e após recarga com solução fluoretada = Fluoride release of orthodontic cements before and after recharge with fluoride solution

    OpenAIRE

    Rogério Lacerda dos SANTOS

    2009-01-01

    Objetivo: O objetivo deste estudo foi comparar a liberação de flúor de cimentos de ionômero de vidro (CIV) utilizados para cimentação ortodôntica, antes e após recarga de flúor. Metodologia: Foram avaliados três CIV: Meron (VOCO), Vidrion C (SS WHITE) e Ketac-Cem (3M ESPE). A liberação de flúor foi medida através de eletrodo íon seletivo conectado a um analisador de íons após 1 h e 1, 3, 7, 14, 21 e 28 dias. Para avaliação da recarga de flúor e capacidade de retenção de flúor, os espécimes fo...

  12. Efeitos do flúor em folhas de plantas aquáticas de Salvinia auriculata Fluoride effects on leaves of aquatic Salvinia auriculata

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Pereira Peixoto

    2005-08-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos do flúor em folhas de plantas aquáticas de Salvinia auriculata Aubl., visando fornecer subsídios para a utilização dessa espécie, no monitoramento da poluição ambiental, causada por esse elemento tóxico. As plantas foram cultivadas sob condições controladas, em vasos com solução nutritiva, e submetidas à aplicação de chuva simulada contendo KF, nas concentrações de 0, 13, 26 e 39 mM, pela manhã, durante cinco dias sucessivos. Os resultados evidenciaram a ocorrência de alterações morfológicas, com o desenvolvimento de lesões nos tricomas e na porção adaxial do limbo foliar. As alterações nas atividades das enzimas peroxidase, polifenol oxidase, superóxido dismutase e catalase indicaram a ocorrência de danos oxidativos em resposta ao flúor, embora testes relacionados à peroxidação dos lipídios tenham apresentado resultados negativos. As alterações na concentração de pigmentos também direcionam para a ocorrência de estresse oxidativo, causado pelo flúor, presente na chuva simulada. Como as alterações morfológicas, enzimáticas e na composição de pigmentos, de plantas de S. auriculata, são passíveis de detecção por métodos relativamente simples, elas podem ser empregadas no biomonitoramento da poluição atmosférica, causada por esse elemento altamente reativo.The objective of this work was to evaluate the effects of fluoride on leaves of aquatic Salvinia auriculata Aubl., to supply subsidies for the use of this species as an environmental pollution bioindicator. The plants were cultivated under controlled conditions in pots containing nutritive solutions, and were submitted to simulated rain containing KF, in concentrations of 0, 13, 26 and 39 mM, in the morning, during five consecutive days. Results evidenced the occurrence of morphological and anatomical damages involving trichome and adaxial surface of the leaf necrosis. Alterations in the

  13. Simulating the lava flow formed during the 2014-2015 Holuhraun eruption (Bardarbunga volcanic system, Iceland) by using the new F-L probabilistic code

    Science.gov (United States)

    Tarquini, Simone; de'Michieli Vitturi, Mattia; Jensen, Esther H.; Barsotti, Sara; Pedersen, Gro B. M.; Coppola, Diego

    2015-04-01

    The 2014-2015 fissure eruption in Holuhraun started when a new code (named F-L) was being developed. The availability of several digital Elevation Models of the area inundated by the lava and the availability of continuously updated maps of the flow (collected in the field and through remote sensing imagery) provided an excellent opportunity for testing and calibrating the new code against an evolving flow field. Remote sensing data also provided a constrain on the effusion rate. Existing numerical codes for the simulation of lava flow emplacement are based either on the solution of some simplification of the physical governing equations of this phenomenon (the so-called "deterministic codes" - e.g. Hidaka et al. 2005; Crisci et al. 2010), or, instead, on the evidence that lava flows tend to follow the steepest descent path from the vent downhill (the so-called "probabilistic codes" - e.g. Favalli et al. 2005). F-L is a new code for the simulation of lava flows, which rests on an approach similar to the one introduced by Glaze and Baloga (2013), and can be ascribed to the "probabilistic family" of lava flow simulation codes. Nevertheless, in contrast with other probabilistic codes (e.g. Favalli et al. 2005), this code explicitly tackles not only the direction of expansion of the growing flow and the area covered, but also the volume of the emplaced lava over time, and hence the supply rate. As a result, this approach bridges the stochastic point of view of a plain probabilistic code with one of the most critical among the input parameters considered by deterministic codes, which is the effusion rate during the course of an eruption. As such, a similar code, in principle, can tackle several aspects which were previously not addressed within the probabilistic approach, which are: (i) the 3D morphology of the flow field (i.e. thickness), (ii) the implications of the effusion rate in the growth of the flow field, and (iii) the evolution of the lava coverage over time

  14. Clinical effectiveness of a one-step self-etch adhesive in non-carious cervical lesions at 2 years.

    Science.gov (United States)

    Ermis, R Banu; Van Landuyt, Kirsten L; Cardoso, Marcio Vivan; De Munck, Jan; Van Meerbeek, Bart; Peumans, Marleen

    2012-06-01

    A 2-year randomized, controlled prospective study evaluated the clinical effectiveness of a one-step self-etch adhesive and a "gold-standard" three-step etch-and-rinse adhesive in non-carious Class-V lesions. The null hypothesis tested was that the one-step self-etch adhesive does perform clinically equally well as the three-step etch-and-rinse adhesive. A total of 161 lesions in 26 patients were restored with Clearfil AP-X (Kuraray). The restorations were bonded either with the "all-in-one" adhesive Clearfil S3 Bond (Kuraray) or with the three-step etch-and-rinse adhesive Optibond FL (Kerr). The restorations were evaluated at baseline and after 6 months, 1 and 2 years, regarding their retention, marginal adapation, marginal discoloration, caries occurrence, preservation of tooth vitality and post-operative sensivity. Retention loss, severe marginal defects and/or discoloration that needed intervention (repair or replacement) and the occurrence of caries were considered as clinical failures. The recall rate at 2 years was 93.8%. Only one Clearfil S3 Bond restoration was lost at the 2-year recall. All other restorations were clinically acceptable. The number of restorations with defect-free margins decreased severely during the 2-year study period (to 6.7% and 25.3% for Clearfil S3 Bond and Optibond FL, respectively). The Clearfil S3 Bond restorations presented significantly more small marginal defects at the enamel side than the Optibond FL restorations (Clearfil S3 Bond: 93.3%; Optibond FL: 73.3%; p = 0.000). Superficial marginal discoloration increased in both groups (to 53.3% and 36% for Clearfil S3 Bond and Optibond FL, respectively) and was also more pronounced in the Clearfil S3 Bond group (p = 0.007). After 2 years, the simplified one-step self-etch adhesive Clearfil S3 Bond and the three-step etch-and-rinse adhesive Optibond FL were clinically equally successful, even though both adhesives were characterized by progressive degradation in marginal

  15. Brushless DC motor drives supplied by PV power system based on Z-source inverter and FL-IC MPPT controller

    Energy Technology Data Exchange (ETDEWEB)

    Mozaffari Niapour, S.A.KH., E-mail: s.a.kh.mozaffari.niapour@gmail.com [Faculty of Electrical and Computer Engineering, University of Tabriz, 51664 Tabriz (Iran, Islamic Republic of); Danyali, S.; Sharifian, M.B.B.; Feyzi, M.R. [Faculty of Electrical and Computer Engineering, University of Tabriz, 51664 Tabriz (Iran, Islamic Republic of)

    2011-08-15

    Highlights: {yields} Employing the BLDC motor in water pumping systems. {yields} Utilizing the ZSI as a single-stage power converter in the PV water pumping systems based on BLDC motor. {yields} Improvement of the conventional IC MPPT method with the fuzzy logic control scheme to save more energy from the PV array. {yields} Taking the advantages of the DTC drive of the BLDC motor. {yields} Optimizing the water pumping system speed response characteristic by PSO. - Abstract: This paper discusses operation performance of a water pumping system consist of a brushless dc (BLDC) motor coupled a centrifugal pump and accompanying a Z-source inverter (ZSI) fed by a photovoltaic (PV) array, to be improved. Despite conventional double-stage power converters, this paper proposes utilizing a single-stage ZSI to extract the maximum power of the PV array and supply the BLDC motor simultaneously. Utilizing the ZSI provides some inherent advantages such as high efficiency and low cost, which is very promising for PV systems due to its novel voltage buck/boost capability. In addition, in order to precisely perform the maximum power point tracking (MPPT) of the PV array the fuzzy logic-incremental conductance (FL-IC) MPPT scheme is proposed. The proposed FL-IC MPPT scheme provides enough modification to the conventional IC method to enjoy an appropriate variable step size MPPT control signal for the ZSI. Moreover, direct torque control (DTC) is found more effective in comparison with hysteresis current control with current shaping to drive the BLDC motor, because it benefits from faster torque response, reduced torque ripple, less sensitivity to parameters variations, and simple implementation. In the mean time, due to the frequently variations of the PV power generation; delivered mechanical power to the centrifugal pump is variable. Thus, the BLDC motor should be driven with variable reference speed. In order to improve the speed transient response of the BLDC motor and enhance

  16. Hallazgos clínicos y de laboratorio presentes en mujeres adolescentes embarazadas residentes en Costa Rica y con al menos dos consultas de control prenatal en el Hospital Calderón Guardia del 10 de mayo al 21 de mayo del 2010

    Directory of Open Access Journals (Sweden)

    Yessenia Brenes Madrigal

    2010-09-01

    Full Text Available El presente es un estudio descriptivo observacional de cincuenta y tres expedientes de pacientes de la clínica de adolescentes del Hospital Calderón Guardia de donde se obtuvieron datos de hemoglobina, hematocrito, peso, talla y otros, con el fin de determinar la frecuencia de anemia y los patrones de ganancia de pero adecuados e inadecuados. Menos del 10 % de las pacientes presentaron anemia y aproximadamente la mitad tuvieron una inadecuada ganancia de peso y de estas la gran mayoría por pobre ganancia de peso. No se encontró una alta incidencia de anemia en esta población sin embargo en las que si la presentaron se encontraba asociada a un bajo peso para la edad gestacional, lo cual concuerda en la literatura existente. En cuanto a la ganancia de peso se obtuvieron resultados que demuestran que en las adolescentes embazadas la presencia de una inadecuada ganancia de peso es frecuente por lo que se debe tener en cuenta como factores asociados a este cuando se trabaja en el área de salud.This is an observational descriptive study about fifty-three patients records from the adolescents clinic at Calderon Guardia Hospital. Data about hemoglobin, hematocrit, weight and height, among others, were taken into account in order to determine the frequency of anemia and the adequate and inadequate weight gain patterns. Less than 10% of patients had anemia, and about half of them had inadequate weight gain or poor weight gain. There was not a high incidence of anemia in this population; however, in the ones in which anemia was found, it was due to low weight on gestational age, as it has been shown in the existing literature in this field . Research showed that inadequate weight gain on pregnant teenagers is common, and that this aspect should be taken into account when working in the health area.

  17. Metaphrase: an aid to the clinical conceptualization and formalization of patient problems in healthcare enterprises.

    Science.gov (United States)

    Tuttle, M S; Olson, N E; Keck, K D; Cole, W G; Erlbaum, M S; Sherertz, D D; Chute, C G; Elkin, P L; Atkin, G E; Kaihoi, B H; Safran, C; Rind, D; Law, V

    1998-11-01

    Patient descriptors, or "problems," such as "brain metastases of melanoma" are an effective way for caregivers to describe patients. But most problems, e.g., "cubital tunnel syndrome" or "ulnar nerve compression," found in problem lists in an Electronic Medical Record (EMR) are not comparable computationally--in general, a computer cannot determine whether they describe the same or a related problem, or whether the user would have preferred "ulnar nerve compression syndrome." Metaphrase is a scalable, middleware component designed to be accessed from problem-manager applications in EMR systems. In response to caregivers' informal descriptors it suggests potentially equivalent, authoritative, and more formally comparable descriptors. Metaphrase contains a clinical subset of the 1997 UMLS Metathesaurus and some 10,000 "problems" from the Mayo Clinic and Harvard Beth Israel Hospital. Word and term completion, spelling correction, and semantic navigation, all combine to ease the burden of problem conceptualization, entry and formalization.

  18. Alkali-soluble fluoride deposition on enamel after professional application of topical fluoride in vitro Formação de flúor fracamente ligado ao esmalte após a aplicação tópica profissional de flúor in vitro

    Directory of Open Access Journals (Sweden)

    Mitsue Fujimaki Hayacibara

    2004-03-01

    Full Text Available Since the efficacy of topical fluoride products is related to the fluoride (F availability and its reactivity with enamel, this study was conducted. The F concentration of the following materials was verified: I- acidulated phosphate fluoride (APF gel (1.23% F, II- APF foam (1.23% F and III- Varnish (2.26% F. Forty blocks of bovine enamel were divided into 4 groups and treated according to the materials described, being one of them used as control. Loosely bound fluoride (''CaF2'' was determined on enamel after extraction with 1.0M KOH and analyzed by ion-selective electrode. Total F concentration found in gel was 12,642, in foam 12,755 and in varnish 23,183 mg F/g. All products formed statistically higher amounts of ''CaF2'' on enamel compared to the control group (p 0.05. Thus, ''CaF2'' formation was not proportional to the total F content in the products, suggesting that the pH and the vehicle used are more important.Considerando que a eficácia dos produtos para aplicação tópica profissional de flúor (géis, espumas e vernizes está relacionada com a reatividade do flúor (F com o esmalte e sendo esta dependente da disponibilidade do F em cada produto, este estudo foi conduzido. A concentração de F nos seguintes produtos foi estudada: I - Flúor Fosfato Acidulado (FFA gel (1,23% F, II - FFA espuma (1,23% F e III- Verniz fluoretado (2,26% F. Foram confeccionados 40 blocos de esmalte bovino, tratados de acordo com os grupos descritos, sendo um deles utilizado como controle. O F fracamente ligado (''CaF2'' ao esmalte foi determinado após a extração com 1.0 M KOH e analisado em eletrodo específico. A concentração de F encontrada no gel foi de 12.642, na espuma 12.755 e no verniz 23.183 mg F/g. Todos os produtos formaram uma quantidade significantemente maior de ''CaF2'' na superfície do esmalte, comparado ao grupo controle (p 0,05. Assim, a formação de ''CaF2'' na superfície do esmalte não foi proporcional ao conteúdo de F nos

  19. Le grand livre de l'égalité femmes-hommes réfléchir autrement : agir pleinement

    CERN Document Server

    Pascal, V

    2016-01-01

    Faut-il attendre 100 ans pour vivre l'égalité pleine et entière entre les femmes et les hommes ? L'égalité femmes - hommes est un sujet Humain, d'hier, d'aujourd'hui et de demain. Les inégalités persistent, des solutions existent ! Quel que soit votre sexe, votre âge, votre statut, votre métier, votre culture... vous pouvez devenir acteur de ce changement. Valérie Pascal et Catherine Sexton vous invitent à : Réfléchir autrement sur les enjeux de l'égalité femmes - hommes. Ce livre vous donne un panorama sur l'évolution des droits des femmes et des lois en matière d'égalité. Il vous fait découvrir les multiples visions sur le genre, principalement sociales et scientifiques, et apporte des clés pour agir sur les stéréotypes inconscients, facteurs de sexisme. Agir pleinement : quatre leviers peuvent être activés simultanément : Les solutions légales et citoyennes. La gouvernance et la culture d'entreprise. Le développement de l'intelligence individuelle. Le renforcement de l'intellige...

  20. Review: Marcus Syring; Erik Flügge (Hrsg.: Die Erstbegegnung mit dem Politischen: Erfahrungsorientierte politische Erstkontakte in Unterricht, Schule und Lebenswelt

    Directory of Open Access Journals (Sweden)

    Kramer, Hans-Ulrich

    2014-12-01

    Full Text Available Der im Prolog-Verlag erschienene Sammelband Die Erstbegegnung mit dem Politischen beschäftigt sich mit theoretisch unterfütterten und empirisch erprobten Konzepten, mit deren Hilfe Kinder und Jugendliche innerhalb der Schule (Teil I oder auch außerschulisch bzw. an der Schnittstelle Schule/Umwelt (Teil II didaktisch an das politische Geschehen herangeführt werden sollen – und somit eine (positive Erstbegegnung mit dem Politischen erleben können. Dabei fordern die Autoren einen Politikunterricht, der an jene politische Erfahrungen der Kinder und Jugendlichen anknüpft, die diese in ihrer Familie und ihrem sozialen Umfeld gemacht haben bzw. machen können. Dies ist mit dem Neologismus ‚erfahrungsorientiert‘ im Untertitel gemeint. Dieser Unterricht soll es den Lernenden ermöglichen, politische Strukturen im eigenen Handeln zu erkennen und sich selbst als politische Akteure verstehen zu lernen. Erfahrungsorientierung als das zentrale Prinzip für die politische Bildung in- und außerhalb der Schule knüpfe direkt an das Denken des „Demokratie-Didaktikers John Dewey“ (12 zu Beginn des 20. Jahrhunderts an, wie Syring/Flügge in ihrer Einleitung zum Sammelband betonen: „Damals wie heute liegt dem Ansatz die Idee zugrunde, dass situatives Lernen mit und an konkreten Erfahrungen intensiver ist.“ (12.

  1. Chemical speciation studies on DU contaminated soils using flow field flow fractionation linked to inductively coupled plasma mass spectrometry (FlFFF-ICP-MS).

    Science.gov (United States)

    Brittain, S R; Cox, A G; Tomos, A D; Paterson, E; Siripinyanond, A; McLeod, C W

    2012-03-01

    Flow field flow fractionation (FlFFF) in combination with inductively coupled plasma mass spectrometry (ICP-MS) was used to study the chemical speciation of U and trace metals in depleted uranium (DU) contaminated soils. A chemical extraction procedure using sodium pyrophosphate, followed by isolation of humic and fulvic substances was applied to two dissimilar DU contaminated sample types (a sandy soil and a clay-rich soil), in addition to a control soil. The sodium pyrophosphate fractions of the firing range soils (Eskmeals and Kirkcudbright) were found to contain over 50% of the total U (measured after aqua regia digestion), compared to approximately 10% for the control soil. This implies that the soils from the contaminated sites contained a large proportion of the U within more easily mobile soil fractions. Humic and fulvic acid fractions each gave characteristic peak maxima for analytes of interest (Mn, Fe, Cu, Zn, Pb and U), with the fulvic acid fraction eluting at a smaller diameter (approximately 2.1 nm on average) than the humic fraction (approximately 2.4 nm on average). DU in the fulvic acid fraction gave a bimodal peak, not apparent for other trace elements investigated, including natural U. This implies that DU interacts with the fulvic acid fraction in a different way to all other elements studied. This journal is © The Royal Society of Chemistry 2012

  2. High-titer lactic acid production by Lactobacillus pentosus FL0421 from corn stover using fed-batch simultaneous saccharification and fermentation.

    Science.gov (United States)

    Hu, Jinlong; Lin, Yanxu; Zhang, Zhenting; Xiang, Ting; Mei, Yuxia; Zhao, Shumiao; Liang, Yunxiang; Peng, Nan

    2016-08-01

    Because the cost of refined sugar substrate and limit of worldwide food availability, lignocellulosic materials are attractive for use in lactic acid (LA) production. In this study, we found Lactobacillus pentosus strain FL0421 produced LA with high yields (0.52-0.82g/g stover) from five NaOH-pretreated and washed agro stovers through simultaneous saccharification and fermentation (SSF). We developed a fed-batch SSF process at 37°C and pH 6.0 using the cellulase of 30FPU/g stover and 10g/L yeast extract in a 5-L bioreactor to produce LA from 14% (w/w) NaOH-pretreated and washed corn stover under non-sterile condition. The LA-titer, yield and productivity reached 92.30g/L, 0.66g/g stover and 1.92g/L/h, respectively; and acetic acid titer and yield reached 34.27g/L and 0.24g/g stover. This study presented a feasible process for LA production from agro stovers and provided a candidate strain for genetic engineering for high-titer and -yield lignocellulosic LA production. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Mineralogía y termo-barometría de los Complejos máficos Sol de Mayo y Suya Taco, Norte de las Sierras de Comechingones, Córdoba

    Directory of Open Access Journals (Sweden)

    Alina M. Tibaldi

    2008-03-01

    Full Text Available Este trabajo presenta un estudio detallado de la petrografía, mineralogía química y termo-barometría de dos complejos máficos que afloran al norte de la sierra de Comechingones. Se aplicaron un conjunto de termómetros y barómetros empíricos con el propósito de determinar los rangos de P y T absolutas de cristalización de estas rocas. Las temperaturas de equilibrio en pares de piroxenos (cpx-opx se estimaron usando tres termómetros independientes. Dos calibraciones termométricas (Wells 1977, Kretz 1982 dan resultados consistentes y razonables indicando que los piroxenos registran condiciones de cristalización magmática (920-1150ºC, mientras que la tercera calibración (Lindsley 1983 estima temperaturas muy inferiores. Esta discrepancia puede estar relacionada con el hecho de que la última calibración no sería aplicable a rocas que cristalizaron a partir de magmas ricos en hierro. Por su parte, la termometría Amph-Pl sugiere temperaturas de equilibrio comprendidas entre 750-850ºC, para composiciones típicas de núcleos, mientras que para composiciones representativas de los bordes de grano las temperaturas estimadas son significativamente inferiores (< 600ºC comportamiento que sugiere que el anfíbol cristalizó principalmente en una etapa post-magmática. Las temperaturas de intercambio para Fe-Mg entre opx-bt muestran que este par mineral se equilibró entre dos rangos térmicos bien definidos (430-650ºC y 740-1030ºC, lo que sugiere que las biotitas pueden haber cristalizado tanto en una etapa tardío magmática como post-magmática. Las formulaciones barométricas muestran cierta variabilidad en función de las calibraciones utilizadas, no obstante, sistemáticamente presentan un patrón de valores en el cual las presiones de equilibrio determinadas en el Complejo Suya Taco son inferiores (5,5 ± 1 kbar a las obtenidas en el Complejo Sol de Mayo (8 ± 1 kbar. En general, este resultado es consistente con las estimaciones

  4. Patrón de liberación de flúor in vitro en sellantes fluorados de resina In vitro fluoride-release profile of fluoridated resin-based sealants

    Directory of Open Access Journals (Sweden)

    S Gómez

    2011-12-01

    Full Text Available Objetivo: Comparar in vitro la cantidad de fluoruros liberados por los principales sellantes de puntos y fisuras basados en resina comercialmente disponibles en Latinoamérica. Material y Métodos: Se evaluó la liberación de fluoruros in vitro en tres sellantes fluorados de puntos y fisuras: Helioseal F (HF, Fissurit F (FF, Clinpro (CF y Delton (D, sin flúor como control. Se utilizaron 28 discos de 12 mm de diámetro y 2 mm de espesor (n=7 por grupo. Las muestras fueron almacenadas en 5 ml de agua ultra de-ionizada con pH neutro a 37º C por 93 días. La liberación de fluoruros fue medida mediante un electrodo iónico selectivo a los 1, 2, 3, 8, 15, 28 y 93 días. Los datos fueron analizados con el test ANOVA y Tukey (pAim: To compare in vitro the amount of fluoride released from the main pit and fissure sealant resin-based on commercially available in Latin America. Materials and Methods: Twenty-eight samples of 12 x 2 mm were made from three commercial fluoridated resin-based sealants: Helioseal F (HF, Fissurit F (FF, Clinpro (CF and without fluoride Delton (D, as a control. Samples were stored in 5 ml of deionized water at 37° C and neutral pH. Fluoride releases were measured at 1, 2, 3, 8, 15, 28 and 93 days with an ion-selective electrode. Data were analyzed using ANOVA and one-way and Tukey (p0.05. Conclusion: The fluoride-release profile is similar for the fluoridated resin-based sealants under study: a high release during the first two days and afterwards, a very slow release. These results can explain the lack of differences in caries rate between fluoridated and non-fluoridated resin-based sealants observed in clinical trials.

  5. Natural fluoride levels from public water supplies in Piauí State, Brazil Concentração de flúor in natura em águas de abastecimento público no Piauí, Brasil

    Directory of Open Access Journals (Sweden)

    Josiene Saibrosa da Silva

    2009-12-01

    Full Text Available The aim of this work was to determine the natural fluoride concentrations in public water supplies in Piauí State, Brazil, in order to identify cities in risk for high prevalence of dental fluorosis. For each city, two samples of drinking water were collected in the urban area: one from the main public water supply and another from a public or residential tap from the same source. Fluoride analyses were carried out in duplicate using a specific ion electrode and TISAB II. From a total of 222 cities in Piauí, 164 (73.8% samples were analyzed. Urban population in these towns corresponds to 92.5% of the whole state with an estimated population of 1,654,563 inhabitants from the total urban population (1,788,590 inhabitants. A total of 151 cities showed low fluoride levels (O objetivo deste trabalho foi realizar um levantamento dos teores residuais de flúor (F in natura da água de abastecimento em municípios do Piauí para identificar localidades com risco de elevada prevalência de fluorose dentária. Para cada município, foram coletadas duas amostras da água de abastecimento da zona urbana, uma amostra da principal fonte de abastecimento público do município e a outra de uma torneira pública ou residencial abastecida pela mesma fonte. As análises de flúor foram realizadas em duplicata, utilizando um eletrodo específico e TISAB II. Dos 222 municípios do Piauí, 164 (73,8% enviaram amostras para análise. A população urbana desses municípios corresponde a 92,5% (1.654.536 habitantes da população urbana total do estado (1.788.590 habitantes. Observou-se que 151 municípios apresentam baixos teores residuais de flúor ( 0,81 mg/L. Conclui-se que a maioria dos municípios do Piauí possui água de abastecimento com baixos teores de flúor residual. O risco de uma elevada prevalência de fluorose dentária pelo flúor residual da água de abastecimento é pouco provável. Estudos sobre a prevalência de fluorose dentária no Piau

  6. Fluoride intake from regular and low fluoride dentifrices by 2-3-year-old children: influence of the dentifrice flavor Ingestão de flúor após uso de dentifrícios convencionais e de baixa concentração de flúor por crianças de 2-3 anos de idade: influência do sabor do dentifrício

    Directory of Open Access Journals (Sweden)

    Samanta Mascarenhas Moraes

    2007-09-01

    Full Text Available This study evaluated the fluoride intake from dentifrices with different fluoride concentrations ([F] by children aged 24-36 months, as well as the influence of the dentifrice flavor in the amount of fluoride ingested during toothbrushing. Thirty-three children were randomly divided into 3 groups, according to the [F] in the dentifrices: G-A (523 µgF/g, G-B (1,062 µgF/g and G-C (1,373 µgF/g. Dentifrices A and B are marketed for children, while dentifrice C is a regular product. The amount of F ingested was indirectly obtained, subtracting the amount expelled and the amount left on the toothbrush from the amount initially loaded onto the brush. The results were analyzed by ANOVA, Tukey's test and linear regression analysis (p 0.05. Mean daily fluoride intake from dentifrice for G-A, G-B and G-C was 0.022ª, 0.032ª and 0.061b mg F/kg body weight, respectively (p Avaliou-se a ingestão de flúor após uso de dentifrícios contendo diferentes concentrações de flúor ([F] por crianças entre 24-36 meses de idade, além da influência do sabor do dentifrício na quantidade de flúor ingerida durante a escovação. Dividiram-se 33 crianças aleatoriamente em 3 grupos, de acordo com a [F] nos dentifrícios: G-A (523 µgF/g, G-B (1.062 µgF/g e G-C (1.373 µgF/g. Os dentifrícios A e B são infantis, e o C, convencional. A quantidade de flúor ingerida foi indiretamente obtida subtraindo-se a quantidade de flúor expelida e a quantidade que restou na escova daquela inicialmente carregada na escova. Os resultados foram analisados por ANOVA, teste de Tukey e análise de regressão linear (p 0,05. A ingestão média diária de flúor para G-A, G-B e G-C foi 0,022ª, 0,032ª e 0,061b mg F/kg de peso corporal, respectivamente (p < 0,01. Houve uma forte correlação positiva (r = 0,86, p < 0,0001 entre a quantidade de dentifrício utilizada e a quantidade de flúor ingerida durante a escovação. Os resultados indicam a necessidade de se instruir pais e

  7. In Vivo Photoacoustic and Fluorescence Cystography Using Clinically Relevant Dual Modal Indocyanine Green

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    Sungjo Park

    2014-10-01

    Full Text Available Conventional X-ray-based cystography uses radio-opaque materials, but this method uses harmful ionizing radiation and is not sensitive. In this study, we demonstrate nonionizing and noninvasive photoacoustic (PA and fluorescence (FL cystography using clinically relevant indocyanine green (ICG in vivo. After transurethral injection of ICG into rats through a catheter, their bladders were photoacoustically and fluorescently visualized. A deeply positioned bladder below the skin surface (i.e., ~1.5–5 mm was clearly visible in the PA and FL image using a laser pulse energy of less than 2 mJ/cm2 (1/15 of the safety limit. Then, the in vivo imaging results were validated through in situ studies. Our results suggest that dual modal cystography can provide a nonionizing and noninvasive imaging tool for bladder mapping.

  8. The absence of longitudinal data limits the accuracy of high-throughput clinical phenotyping for identifying type 2 diabetes mellitus subjects.

    Science.gov (United States)

    Wei, Wei-Qi; Leibson, Cynthia L; Ransom, Jeanine E; Kho, Abel N; Chute, Christopher G

    2013-04-01

    To evaluate the impact of insufficient longitudinal data on the accuracy of a high-throughput clinical phenotyping (HTCP) algorithm for identifying (1) patients with type 2 diabetes mellitus (T2DM) and (2) patients with no diabetes. Retrospective study conducted at Mayo Clinic in Rochester, Minnesota. Eligible subjects were Olmsted County residents with ≥1 Mayo Clinic encounter in each of three time periods: (1) 2007, (2) from 1997 through 2006, and (3) before 1997 (N = 54,283). Diabetes relevant electronic medical record (EMR) data about diagnoses, laboratories, and medications were used. We employed the HTCP algorithm to categorize individuals as T2DM cases and non-diabetes controls. Considering the full 11 years (1997-2007) as the gold standard, we compared gold-standard categorizations with those using data for 10 subsequent intervals, ranging from 1998-2007 (10-year data) to 2007 (1-year data). Positive predictive values (PPVs) and false-negative rates (FNRs) were calculated. McNemar tests were used to determine whether categorizations using shorter time periods differed from the gold standard. Statistical significance was defined as P FNRs, respectively, were 70% and 25% for case identification and 59% and 67% for control identification. All time frames differed significantly from the gold standard, except for the 10-year period. The accuracy of the algorithm reduced remarkably as data were limited to shorter observation periods. This impact should be considered carefully when designing/executing HTCP algorithms. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  9. Comparison of different methods of platelet count and its clinical application

    Institute of Scientific and Technical Information of China (English)

    Bin Li; Chuan Wang

    2016-01-01

    Objective:To compare the results of different platelet mean volume (MPV) with the method of instrument and manual counting of platelet and its application in clinical practice.Method:According to prompts Sysmex xn (10) B4 detection results MPV. The 246 samples divided for four groups, with Sysmex xn (10) B4, Mindray BC6800 blood cell analyzer, artificial bovine Bao counting plate platelet count number. The detection results are paired t-test.Results:When 5.4 fL≤MPV≤7.4 fL, 2 instruments and artificial platelet count results showed no significant difference; When 7.5 fL≤MCV≤9.0 fL, 2 instruments and artificial platelet count results showed no significant difference, Sysmex XN (10) B4 slightly lower test results, Mindray BC6800 test results closer to the true value; When 9.1 fL≤MCV≤12.0 fL, Sysmex XN (10) B4 and artificial platelet count results were significantly, and manual counting Mindray BC6800 platelet count was no significant difference; When MPV≧ 12.1 fL, 2 instrument testing platelet counting and artificial platelets results difference had statistical significance, platelet test results between two instruments are low.Conclusion:MPV is the main factors of effect of platelet count by apparatus, when the MPV increase should be the manual assay of platelet count in order to ensure accuracy, more realistically reflect the actual situation in the patient, and provide more valuable diagnostic basis for clinical.

  10. Knoop hardness of enamel and shear bond strength of brackets bonded with composite resin with and without fluoride Dureza Knoop do esmalte e resistência ao cisalhamento de braquetes colados com resina composta com e sem flúor

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    Silvia Amélia Scudeler Vedovello

    2012-08-01

    Full Text Available OBJECTIVE: The aim of this study was to evaluate the Knoop hardness of enamel, shear bond strength and failure pattern (adhesive, bracket/resin interface or mixed after bonding and debonding brackets, using resin composite with fluoride (Ortho Lite Cure, Ortho Source® and without fluoride (Orthobond, Morelli®. METHODS: Fragments (6 mm x 6 mm of 40 bovine incisor crowns were embedded in acrylic self-polymerizing resin. The Knoop hardness measurements were performed before and after bonding metal brackets. The specimens were divided into two groups, according to composite resin: with fluoride (Ortho Lite Cure, Ortho Source® and without fluoride (Orthobond, Morelli®. After bonding, the specimens were submitted to demineralization and remineralization cycling for 14 days. Shear bond strength testing was performed in a universal test machine (EMIC, at 5 mm/min crosshead speed. RESULTS: There was no significant difference in shear bond strength between Groups I and II. After demineralization and remineralization procedures (DE/RE, the specimens bonded with Ortho Lite Cure showed higher Knoop hardness than Orthobond. For both groups there was predominance of failure at bracket/resin interface. CONCLUSION: specimens bonded with fluoride resin composite showed higher microhardness after DE/RE cycling than those bonded with resin composite without fluoride, although no difference in shear bond strength was found.OBJETIVO: o propósito deste estudo foi avaliar a dureza Knoop do esmalte, resistência ao cisalhamento e padrão de falha (adesiva; interface braquete/resina; e mista após a colagem e descolagem de braquetes, utilizando uma resina composta com flúor (Ortho Lite Cure, Ortho Source® e uma sem flúor (Orthobond, Morelli®. MÉTODOS: fragmentos (6mm x 6mm de 40 coroas de incisivos bovinos foram embutidos em resina acrílica autopolimerizável. A dureza Knoop foi avaliada antes e após a colagem dos braquetes metálicos. Os corpos de prova

  11. Sob o olhar do flâneur: características da crônica em uma narrativa de Lygia Bojunga - doi: 10.4025/actascilangcult.v35i3.12289

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    Marta Yumi Ando

    2013-03-01

    Full Text Available O presente estudo tem por objetivo empreender uma leitura da narrativa Numa rua de Istambul de Lygia Bojunga, sob a perspectiva de estudos teórico-críticos sobre a crônica e a concepção de flânerie. Nessa medida, procuramos investigar características da crônica presentes nessa narrativa e como o narrador aí configurado se aproxima do flâneur. Antes, porém, apresentamos uma visão geral da consecução da obra Feito à Mão (1996 em que se insere tal texto, no intuito de contextualizar suas circunstâncias de produção.

  12. Influência da aplicação de flúor sobre a rugosidade superficial do ionômero de vidro Vitremer e adesão microbiana a este material

    OpenAIRE

    Denise PEDRINI; Jardim Júnior, Élerson Gaetti [UNESP; Mori, Graziela Garrido [UNESP

    2001-01-01

    Os cimentos ionoméricos representam importante opção de material restaurador em Odontologia e sua adesão à estrutura dental, diminuindo a infiltração marginal, somada à liberação de flúor, inibindo o metabolismo de microrganismos acidogênicos e favorecendo a remineralização dental, podem diminuir a ocorrência de cárie secundária. A aplicação tópica de géis acidulados ou neutros contendo flúor tem sido largamente utilizada em Odontologia. No entanto, este procedimento pode afetar a integridade...

  13. Avaliação in vitro da liberação e da recarga de flúor em cimentos de ionômero de vidro

    OpenAIRE

    Evelyn Lopez Leite; Nathielen Regina Presotto; Júlio Cesar Bassi; Fabiana Bucholdz Teixeira Alves; Denise Stadler Wambier

    2013-01-01

    OBJETIVO: Este estudo avaliou a absorção de íons flúor em cimentos de ionômero de vidro de manipulação mecânica e manual, por uma única aplicação tópica de flúor. METODOLOGIA: Os cimentos de ionômeros de vidro (CIVs) Riva Self Cure® (RSC-SDI) e Ketac Molar Easymix® (KME- 3M-ESPE) foram testados com um material controle (RC-resina composta ICE-SDI), após preparo de dez corpos de prova de cada um (n = 30). Esses corpos foram pesados e armazenados em água deionizada para as aferições da liberaçã...

  14. Avaliação da concentração de flúor em águas minerais comercializadas no Brasil Evaluation of fluoride content of bottled drinking waters in Brazil

    Directory of Open Access Journals (Sweden)

    Rita S. Villena

    1996-12-01

    Full Text Available A utilização de flúor sistêmico deve ser controlada em termos de risco/benefício, pois enquanto a subdosagem não trouxer benefício anticárie, a sobredosagem estará associada com fluorose dental. Assim, uma das preocupações é o consumo de águas minerais, o qual tem aumentado nos últimos anos. Deste modo, foi realizado estudo com o objetivo de analisar a concentração de flúor em águas minerais comercializadas no Brasil. Foram analisadas 104 marcas comerciais, de diferentes regiões do País. Utilizou-se eletrodo específico Orion 96-09 e analisador de íons Orion EA 940, previamente calibrados com soluções padrões de flúor. Foram observadas concentrações de flúor variando de 0,0 a 4,4 ppm. Constataram-se: 1 Concentrações significativas de flúor não relatadas pelo produtor; 2 Concentrações de flúor sem significado preventivo anti-cárie, embora o produtor destaque na embalagem "Água Mineral Fluoretada"; 3 Concentrações de flúor capazes de provocar fluorose dental severa, embora o produtor não faça nenhuma referência que o mesmo existe. Conclui-se ser necessário um Sistema de Vigilância Sanitária para o controle de flúor nas águas minerais oferecidas à população brasileira, quer seja em termos de benefício como de risco.The utilization of a systemic fluoride method must be controlled in terms of risks and benefits. The reason for this is that while a small dose will not be effective in preventing dental caries, a larger dose may cause dental fluorosis. Therefore the knowledge of the fluoride concentration found in the bottled mineral waters sold throughout the Brazilian market the consumption of which has increased lately, is of great concern. The objective of the study was the analysis of the concentration of fluoride found in the bottled mineral waters. A hundred and four brands coming from different regions of Brazil were analysed using an Orion 96-09 ion specific electrode and an Orion EA 940

  15. Avaliação in situ de um dentifrício contendo MFP/DCPD na incorporação de flúor e remineralização do esmalte dental humano

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    KOO Hyun

    1999-01-01

    Full Text Available O objetivo deste estudo foi analisar in situ a efetividade de um dentifrício contendo monofluorfosfato (MFP e sistema abrasivo fosfodicálcio diidratado (DCPD, quando comparado com dentifrício placebo. O estudo foi do tipo cross-over com oito voluntários em duas etapas de 45 dias. Os voluntários utilizaram dispositivo intra-oral palatino de resina acrílica contendo 4 blocos de esmalte com lesão de cárie artificial. Após cada etapa, foi analisada a incorporação de flúor (flúor total em ppm F e microdureza (em Knoop dos blocos de esmalte dental. Os resultados obtidos (média ± E.P. das áreas integradas sob as curvas demonstraram que a concentração de flúor incorporado no esmalte tratado com dentifrício MFP/DCPD foi significativamente maior que no placebo (4.508,55 ± 965,82 e 1.485,51 ± 191,72, respectivamente e os dados de microdureza demonstraram que o dentifrício MFP/DCPD foi capaz de remineralizar o esmalte dental em 34%, enquanto no placebo observou-se perda de 14% de mineral. Assim, os dados obtidos deste estudo demonstraram que o dentifrício MFP/DCPD foi efetivo não apenas na incorporação de flúor no esmalte, mas também na capacidade de remineralizar a lesão de cárie, quando comparado com o placebo.

  16. Efetividade de uma técnica educativa na aquisição de conhecimentos por pais sobre uso racional do flúor = Effectiveness of an educative techinique on knowledge acquisition on ratinal use of fluorine by parents

    Directory of Open Access Journals (Sweden)

    Martins, Carolina de Castro

    2006-01-01

    Full Text Available O objetivo do presente estudo foi testar o conhecimento sobre uso racional de flúor adquirido através de grupo de discussão (GD. Um grupo de 47 pais de crianças pré-escolares constituiu a amostra após a assinatura de um termo de consentimento livre e esclarecido. Este estudo foi aprovado por um Comitê de ética em Pesquisa. Para averiguação do nível de conhecimento inicial sobre o tema proposto, os participantes responderam a um questionário com 14 perguntas abertas e fechadas. Seis meses após esta etapa, foi realizado um GD sobre o uso racional de flúor. O GD proposto abordou a metodologia pedagógica problematizadora e contou com a participação ativa dos pais e de três cirurgiões dentistas. Neste momento foram apresentadas afirmações sobre a utilização do flúor pela população, a partir das quais a discussão era deflagrada. Alguns dias após, os pais responderam novamente o questionário inicial. Os dados foram submetidos aos testes estatístico Qui-quadrado e exato de Fisher através do programa SPSS. Houve diferença estatisticamente significante entre praticamente todas as respostas no primeiro e segundo questionários (p < 0,005, sendo que no segundo, houve um maior número de respostas corretas. A técnica educativa avaliada mostrou-se efetiva na incorporação de novos conhecimentos sobre o uso racional de flúor pelos pais, evidenciando a eficácia da metodologia empregada

  17. Avaliação histopatológica da cápsula posterior associada ao implante de lente intraocular com superfície modificada com plasma de flúor e polietilenoglicol em coelhos

    Directory of Open Access Journals (Sweden)

    V. L. Souza

    2015-10-01

    Full Text Available RESUMOO objetivo deste estudo foi avaliar o efeito do tratamento da superfície de lentes intraoculares acrílicas utilizando-se plasma de flúor ou polietilenoglicol na prevenção da opacidade de cápsula posterior. Foram analisados 40 olhos de coelhos, submetidos à cirurgia de facoemulsificação e distribuídos em quatro grupos experimentais (n=10, sendo estes: grupo controle, coelhos sem implante de lente intraocular; grupo com lente intraocular tratada com plasma de polietilenoglicol; grupo com lente intraocular tratada com plasma de flúor; e grupo com lente intraocular comercial. As cápsulas posteriores das lentes dos grupos foram avaliadas por meio de análise histopatológica (morfometria e imuno-histoquímica. Os grupos com lente intraocular tratada com polietilenoglicol e com lente intraocular comercial apresentaram menor espessura da cápsula posterior na avaliação inicial (12 semanas em relação ao grupo controle. No período final de avaliação (6 meses, os tratamentos da superfície da lente intraocular à base de plasma de flúor e polietilenoglicol não reduziram o desenvolvimento das alterações histológicas associadas à opacidade de cápsula posterior. O tratamento das superfícies das lentes intraoculares com plasma de flúor e polietilenoglicol pode ser realizado como adjuvante na prevenção da opacidade de cápsula posterior, pois não causa alterações na morfologia da lente após facoemulsificação.

  18. Expansion of CD34+ cells from human umbilical cord blood by FL and/or TPO gene transfected human marrow stromal cell lines

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Yi(

    2001-01-01

    [1]Luens. K. M., Travis, M. A., Chen, B. P. et al., Thrombopoietin, kit ligand, and flk2/flt3 ligand together induce increased numbers of primitive hematopoietic progenitors from human CD34+Thy+Lin cells with preserved ability to engraft SCID-hu bone, Blood, 1998, 91: 1206-1215.[2]Piacibello, W., Sanavio, F., Garetto, L. et al., Extensive amplification and self-renewal of human primitive hematopoietic stem cells from cord blood, Blood, 1997, 89(8)L 2644-2653.[3]Zhang Yi, Tang Peixian, Li Xiusen et al., Expression of human FL ligand and thrombopoietin genes in a bone marrow stromal cell line by internal ribosome entry site (IRES) sequence, Chin. J. Hematol. (in Chinese), 1999, 20(12): 624-627.[4]Zhou. S., Mao, N., Zhao, M. et al., Effect of recombinant FLT3 ligand (rhFL) on in vitro expansion of human cord blood CD34+ cells. Natl. Med. J. China, 1998, 78: 37-39.[5]Dexter. T. M.. Allen, T. D., Lajtha, L. G. et al., Conditions controlling the proliferation of hematopoietic stem cells in vitro,J. Cell Physiol.. 1997, 91: 335-344.[6]Petzer. A. L., Hogge, D. E.. Lansdorp, P. M. et al., Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium, Pro. Natl. Acad. Sci. USA, 1996, 93:1470-1474.[7]Sirchia, G., Rebulla, P., Placental/umbilical cord blood transplantation, Haematologica, 1999, 84: 738-747.[8]Wineman, J., Moore, K., Lemischka, I. et al., Functional heterogeneity of the hematopoietic microenvironment: Rare stromal elements maintain long-term repopulating stem cells, Blood, 1996, 87: 4082-4090.[9]Szilvassy, S. J., Weller, K. P., Lin, W. et al., Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells, Blood, 1996, 87:4618-4628.[10]Aiuti, A., Fredrich, C., Sieff, C. A. et al., Identification of distinct elements of the stromal

  19. Fluoride content of UHT milks commercially available in Bauru, Brazil Conteúdo de flúor em leites UHT disponíveis comercialmente em Bauru, Brasil

    Directory of Open Access Journals (Sweden)

    Marília Afonso Rabelo Buzalaf

    2006-01-01

    Full Text Available OBJECTIVES: The aims of the present study were to evaluate the fluoride (F concentrations in whole, defatted and chocolate milks commercially available in Brazil and to estimate the daily F intake from these sources. MATERIAL AND METHODS: F concentrations were determined for 23 brands of milks, after HMDS-facilitated diffusion, using a F ion-specific electrode. Possible F ingestion per kg body weight was estimated, based on suggested volumes of formula consumption, for infants aging 1 to 12 months. RESULTS: F concentrations ranged from 0.02 to 1.6 µg/mL F for all brands analyzed. Whole and defatted milks had the lowest F concentrations, ranging from 0.02 to 0.07 µg/mL. With respect to chocolate milks, three brands had F concentrations above 0.5 µg/mL. Some brands of chocolate milks exceeded the dose regarded as the threshold level for the development of dental fluorosis, without taking into account other sources of fluoride intake. CONCLUSION: The high fluoride concentrations found in some brands of chocolate milks in the present study indicate that many products may be important contributors to the total fluoride intake, reinforcing the need of assaying fluoride content of foods and beverages consumed by small children.OBJETIVOS: Os objetivos do presente estudo foram avaliar as concentrações de flúor (F em leites integrais, desnatados e achocolatados disponíveis comercialmente no Brasil e estimar a ingestão diária de F a partir destas fontes. MATERIAL E MÉTODOS: as concentrações de F foram determinadas em 23 marcas de leite, após difusão facilitada por HMDS, usando um eletrodo íon-específico para F. A ingestão provável de F por Kg de peso corporal foi estimada, baseando-se em volumes sugeridos de consumo de fórmulas infantis, para crianças entre 1 e 12 meses de idade. RESULTADOS: As concentrações de F variaram entre 0,02 e 1,6 µg/mL para todas as marcas analisadas. Os leites integrais e desnatados apresentaram as menores

  20. Fraction from wax apple [Syzygium samarangense (Blume) Merrill and Perry] fruit extract ameliorates insulin resistance via modulating insulin signaling and inflammation pathway in tumor necrosis factor α-treated FL83B mouse hepatocytes.

    Science.gov (United States)

    Shen, Szu-Chuan; Chang, Wen-Chang; Chang, Chiao-Li

    2012-01-01

    Inflammation is associated with the development of insulin resistance in Type 2 diabetes mellitus. In the present study, mouse FL83B cells were treated with tumor necrosis factor-alpha (TNF-α) to induce insulin resistance, and then co-incubated with a fraction from wax apple fruit extract (FWFE). This fraction significantly increased the uptake of the nonradioactive fluorescent indicator 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-d-glucose (2-NBDG) in insulin resistant cells. Western blot analysis revealed that, compared with the TNF-α-treated control group, FWFE increased the expression of the insulin receptor (IR), insulin receptor substrate-1 (IRS-1), protein kinase B (Akt/PKB), phosphatidylinositol-3 kinase (PI3K), and glucose transporter 2 (GLUT-2), and increased IR tyrosyl phosporylation, in insulin resistant FL83B cells. However, FWFE decreased phosphorylation of c-Jun N-terminal kinases (JNK), but not the expression of the intercellular signal-regulated kinases (ERK), in the same cells. These results suggest that FWFE might alleviate insulin resistance in TNF-α-treated FL83B cells by activating PI3K-Akt/PKB signaling and inhibiting inflammatory response via suppression of JNK, rather than ERK, activation.