WorldWideScience

Sample records for final design approval

  1. 10 CFR 52.145 - Finality of standard design approvals; information requests.

    Science.gov (United States)

    2010-01-01

    ... approvals; information requests. (a) An approved design must be used by and relied upon by the NRC staff and... any proceeding under part 2 of this chapter. (c) Except for information requests seeking to verify compliance with the current licensing basis of the standard design approval, information requests to the...

  2. 77 FR 24403 - Direct Final Approval of Hospital/Medical/Infectious Waste Incinerators State Plan for Designated...

    Science.gov (United States)

    2012-04-24

    ... AGENCY 40 CFR Part 62 Direct Final Approval of Hospital/Medical/Infectious Waste Incinerators State Plan...). ACTION: Direct final rule. SUMMARY: EPA is approving Illinois' revised State Plan to control air pollutants from ``Hazardous/Medical/Infectious Waste Incinerators'' (HMIWI). The Illinois Environmental...

  3. 77 FR 24451 - Direct Final Approval of Hospital/Medical/Infectious Waste Incinerators State Plan for Designated...

    Science.gov (United States)

    2012-04-24

    ... AGENCY 40 CFR Part 62 Direct Final Approval of Hospital/Medical/Infectious Waste Incinerators State Plan...). ACTION: Proposed rule. SUMMARY: EPA is proposing to approve, through direct final rulemaking, Illinois' revised State Plan to control air pollutants from Hazardous/ Medical/Infectious Waste Incinerators (HMIWI...

  4. 77 FR 24405 - Direct Final Approval of Hospital/Medical/Infectious Waste Incinerators State Plan for Designated...

    Science.gov (United States)

    2012-04-24

    ... AGENCY 40 CFR Part 62 Direct Final Approval of Hospital/Medical/Infectious Waste Incinerators State Plan...). ACTION: Direct final rule. SUMMARY: EPA is approving Indiana's revised State Plan to control air pollutants from ``Hazardous/Medical/Infectious Waste Incinerators'' (HMIWI). The Indiana Department of...

  5. 5 CFR 470.311 - Final project approval.

    Science.gov (United States)

    2010-01-01

    ... Projects § 470.311 Final project approval. (a) The Office of Personnel Management will consider all timely...) The Office of Personnel Management shall provide a copy of the final version of the project plan to... 470.311 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL...

  6. 29 CFR 1952.104 - Final approval determination.

    Science.gov (United States)

    2010-07-01

    ... dam construction projects; and private sector maritime employment on or adjacent to navigable waters... Final approval determination. (a) In accordance with Section 18(e) of the Act and procedures in 29 CFR... exception of temporary labor camps in agriculture, general industry, construction and logging) is at...

  7. 7 CFR 1737.51 - Approval of loan design.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Approval of loan design. 1737.51 Section 1737.51... of Application Procedures § 1737.51 Approval of loan design. RUS shall notify the borrower when the preloan data concerning the system design and costs and subscriber projections have been approved. If...

  8. 78 FR 40015 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2013-07-03

    ... Pollutants; District of Columbia; Control of Emissions From Existing Hospital/Medical/Infectious Waste... taking direct final action to approve a negative declaration for hospital/medical/infectious waste... pollutants) at existing solid waste combustor facilities (designated facilities) whenever standards...

  9. MINIMARS conceptual design: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J.D. (ed.)

    1986-09-01

    This volume contains the following sections: (1) fueling systems; (2) blanket; (3) alternative blanket concepts; (4) halo scraper/direct converter system study and final conceptual design; (5) heat-transport and power-conversion systems; (6) tritium systems; (7) minimars air detritiation system; (8) appropriate radiological safety design criteria; and (9) cost estimate. (MOW)

  10. MINIMARS conceptual design: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J.D. (ed.)

    1986-09-01

    This volume contains the following sections: (1) fueling systems; (2) blanket; (3) alternative blanket concepts; (4) halo scraper/direct converter system study and final conceptual design; (5) heat-transport and power-conversion systems; (6) tritium systems; (7) minimars air detritiation system; (8) appropriate radiological safety design criteria; and (9) cost estimate. (MOW)

  11. 49 CFR 107.403 - Designation of approval agencies.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Designation of approval agencies. 107.403 Section 107.403 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... MATERIALS PROGRAM PROCEDURES Designation of Approval and Certification Agencies § 107.403 Designation...

  12. 25 CFR 224.71 - What standards will the Secretary use to decide to approve a final proposed TERA?

    Science.gov (United States)

    2010-04-01

    ... approve a final proposed TERA? 224.71 Section 224.71 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... the Secretary use to decide to approve a final proposed TERA? The Secretary will consider the best... approve a final proposed TERA. The Secretary must approve a final proposed TERA if it contains...

  13. Hyapproval : final handbook for approval of hydrogen refuelling stations

    NARCIS (Netherlands)

    Wurster, R.; Landinger, H.; Machens, C.; Allidières, L.; Molag, M.; Barron, J.; Reijalt, M.; Hill, H.J.

    2006-01-01

    HyApproval is an EC co-financed Specific Targeted Research Project (STREP) to develop a Handbook facilitating the approval of Hydrogen Refuelling Stations (HRS). The project, started in October 2005, will be performed over 24 months by a balanced partnership including 25 partners from industry, SMEs

  14. Design review report for multiport riser final design review

    Energy Technology Data Exchange (ETDEWEB)

    McWethy, L.M.; Sheen, E.M.

    1994-05-01

    This design review examined the design documents contained in a notebook prepared for the final design review of the multiport riser assembly. This assembly will support the Hydrogen Mitigation Test program for mitigation of safety issues for Hanford Waste Tank 241-SY-101. The purpose of the Multiport Riser is to provide multiple access ports of several diameters in a single 42 inch riser for simultaneous access of test and support equipment. The notebook was titled: {open_quotes}Multiport Riser Final Design Review.{close_quotes} The review was conducted using a database comment registration system whereby the reviewer comments were entered into the database and each comment was given a unique identifier. During the review, each comment was referred to by its identifier. Changes to comments, responses, and actions needed were made with the agreement of the committee and the reviewers at the formal design review meeting held March 1, 1994. When the structural analyses were available, they were distributed for review which allowed closure of all design review comments. Approval of the design was achieved and supporting documents are included in this report.

  15. 13 CFR 108.380 - Final approval as a NMVC Company.

    Science.gov (United States)

    2010-01-01

    ... VENTURE CAPITAL (âNMVCâ) PROGRAM Evaluation and Selection of NMVC Companies § 108.380 Final approval as a... amount of Regulatory Capital set forth in its application, pursuant to § 108.310(a)(1); and (B) The... at least 30 percent of its Regulatory Capital if the Conditionally Approved NMVC Company— (i)...

  16. 25 CFR 224.74 - When must the Secretary approve or disapprove a final proposed TERA?

    Science.gov (United States)

    2010-04-01

    ... proposed TERA? 224.74 Section 224.74 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY... disapprove a final proposed TERA? The Secretary must approve or disapprove a final proposed TERA or a revised final proposed TERA within 270 days of the Director's receipt of a complete application for a TERA....

  17. The LSST Dome final design

    Science.gov (United States)

    DeVries, J.; Neill, D. R.; Barr, J.; De Lorenzi, Simone; Marchiori, Gianpietro

    2016-07-01

    The Large Synoptic Survey Telescope (LSST) is a large (8.4 meter) wide-field (3.5 degree) survey telescope, which will be located on the Cerro Pachón summit in Chile 1. As a result of the Telescope wide field of view, the optical system is unusually susceptible to stray light 2. In addition, balancing the effect of wind induced telescope vibrations with Dome seeing is crucial. The rotating enclosure system (Dome) includes a moving wind screen and light baffle system. All of the Dome vents include hinged light baffles, which provide exceptional Dome flushing, stray light attenuation, and allows for vent maintenance access from inside the Dome. The wind screen also functions as a light screen, and helps define a clear optical aperture for the Telescope. The Dome must operate continuously without rotational travel limits to accommodate the Telescope cadence and travel. Consequently, the Azimuth drives are located on the fixed lower enclosure to accommodate glycol water cooling without the need for a utility cable wrap. An air duct system aligns when the Dome is in its parked position, and this provides air cooling for temperature conditioning of the Dome during the daytime. A bridge crane and a series of ladders, stairs and platforms provide for the inspection, maintenance and repair of all of the Dome mechanical systems. The contract to build the Dome was awarded to European Industrial Engineering in Mestre, Italy in May 2015. In this paper, we present the final design of this telescope and site sub-system.

  18. [Lake Mason and Soo Line Marsh project design approval

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This letter is the approval from the U.S. Fish and Wildlife Service of the designs created by Ducks Unlimited, Inc. for the Lake Mason and Soo Line Marsh National...

  19. 40 CFR 228.15 - Dumping sites designated on a final basis.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Dumping sites designated on a final... DUMPING CRITERIA FOR THE MANAGEMENT OF DISPOSAL SITES FOR OCEAN DUMPING § 228.15 Dumping sites designated on a final basis. (a)(1) The sites identified in this section are approved for dumping the...

  20. 25 CFR 224.75 - What must the Secretary do upon approval or disapproval of a final proposed TERA?

    Science.gov (United States)

    2010-04-01

    ... of a final proposed TERA? 224.75 Section 224.75 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE... Secretary do upon approval or disapproval of a final proposed TERA? Within 10 days of the Secretary's approval or disapproval of a final proposed TERA, the Secretary must notify the tribal governing body...

  1. 76 FR 52997 - Public Company Accounting Oversight Board; Order Approving Proposed Board Funding Final Rules for...

    Science.gov (United States)

    2011-08-24

    ...\\ 15 U.S.C. 7217(b). \\2\\ 15 U.S.C. 78s(b)(1). \\3\\ Release No. 34-64816 (Jul. 6, 2011) [76 FR 40950 (Jul... COMMISSION Public Company Accounting Oversight Board; Order Approving Proposed Board Funding Final Rules for Allocation of the Board's Accounting Support Fee Among Issuers, Brokers, and Dealers, and Other Amendments...

  2. 75 FR 6597 - Determination to Approve Alternative Final Cover Request for the Lake County, MT Landfill...

    Science.gov (United States)

    2010-02-10

    ... Landfill; Opportunity for Public Comment AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of... to approve an alternative final cover for the Lake County landfill, a municipal solid waste landfill... be free of any detects or viruses. Docket: All documents in the docket are listed in the http://www...

  3. 78 FR 72581 - Direct Final Approval of Hospital/Medical/Infectious Waste Incinerator Negative Declaration for...

    Science.gov (United States)

    2013-12-03

    ... AGENCY 40 CFR Part 62 Direct Final Approval of Hospital/Medical/Infectious Waste Incinerator Negative... negative declarations from Michigan and Wisconsin regarding Hospital/Medical/ Infectious Waste Incinerator...) requirements to existing solid waste combustors, including HMIWIs, and provide that EPA should include, as...

  4. 76 FR 61999 - Policy Statement: Inappropriate Design Approval Holder (DAH) Restrictions on the Use and...

    Science.gov (United States)

    2011-10-06

    ... Federal Aviation Administration 14 CFR Part 21 Policy Statement: Inappropriate Design Approval Holder (DAH... the proposed policy statement addressing the action taken by some Design Approval Holders (DAH...(b) requires the holder of a design approval to furnish at least one set of complete Instructions...

  5. Finalizing the DTAG: Implementation and Testing of Design Improvements for Reliability and Availability

    Science.gov (United States)

    2014-09-30

    USB Interface (integrated with electronics box)  A new USB PCB design has been design and fabricated i. Salt water testing to examine...bench, we will then move to testing at pressure. Figure 4 (A) New PCB connector and (B) Experimental setup to test performance in sea water...1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Finalizing the DTAG: Implementation and Testing of Design

  6. ITER Cryoplant Final Design and Construction

    Science.gov (United States)

    Monneret, E.; Benkheira, L.; Fauve, E.; Henry, D.; Voigt, T.; Badgujar, S.; Chang, H.-S.; Vincent, G.; Forgeas, A.; Navion-Maillot, N.

    2017-02-01

    The ITER Tokamak supraconducting magnets, thermal shields and cryopumps will require tremendous amount of cooling power. With an average need of 75 kW at 4.5 K and of 600 kW at 80 K, ITER requires a world class cryogenic complex. ITER then relies on a Cryoplant which consists in a cluster of systems dedicated to the management of all fluids required for the Tokamak operation. From storage and purification to liquefaction and refrigeration, the Cryoplant will supply to the distribution system, all fluids to be circulated in the Tokamak. It includes Liquid Helium Plants and Liquid Nitrogen Plants, which generate all of the refrigeration power, an 80 K helium loop capable to circulate large quantities of helium through thermal shields, and all the auxiliaries required for gas storage, purification, and onsite nitrogen production. From the conceptual phase, the design of the Cryoplant has evolved and is now nearing completion. This proceeding will present the final design of the Cryoplant and the organization for the construction phase. Also the latest status of the ITER Cryogenic System will be introduced.

  7. Final design of a spacer grid using axiomatic design

    Energy Technology Data Exchange (ETDEWEB)

    Park, Gyung-Jin; Lee, Hyun-Ah; Kim, Chong-Ki [Hanyang Univ., Seoul (Korea, Republic of); Song, Gi-Nam [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2007-03-15

    The spacer grid set is a component in the nuclear fuel assembly. The set supports the fuel rod safely. The spacer grid set must have enough strength to sustain external loads such as earthquake. The fretting wear occurs between the spring of the fuel rod and the spacer grid due to the flow-induced vibration after the fuel rod is inserted to the spacer grid set. Design of the spring is carried out by using the independence axiom in axiomatic design to solve the two problems. The spacer grid is divided into two parts for sustaining the impact load and reducing fretting wear based on the function requirements. The design for the impact load is performed through non-linear analysis and the homology theory is adopted to reduce fretting wear achieved for shape optimization. The objective function to be minimized ids the maximum stress and constraints are defined to increase the contact area between the fuel rod and the spring using the homology theory. In the design results, the contact area becomes large and it is conformed by nonlinear static analysis. The final design shows that larger impact loads can be sustained compared to the current model.

  8. Premarket Approval (PMA) Summary Review Memos for 180-Day Design Changes

    Data.gov (United States)

    U.S. Department of Health & Human Services — A 180-day supplement is a request for a significant change in components, materials, design, specification, software, color additive, and labeling to an approved...

  9. Retrievable storage concept designs. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Nickell, R.E.

    1979-03-01

    Three tasks related to the reference design of retrievable storage canisters for radioactive waste have been completed. The three tasks consist of the reference design itself, the definition of failure modes most appropriate for structural integrity determinations for the reference canister, and the development of a failure methodology for the structural integrity of the containers. The reference design is a sealed storage canister concept based upon the waste isolation pilot plant (WIPP) design, with slight modifications. The modifications consist of an alternate lifting yoke arrangement for the top head and a revised bottom head design for absorption of impact energy. Welded closures provide the seal at each end. Overpacking is considered as a possibility, but is not included in the preliminary reference design. The four failure modes that are deemed the most appropriate for the design of the reference canister are: (i) a loss of functional capability; (ii) ductile rupture of the canister; (iii) buckling of the structural members; and (iv) stress corrosion cracking. Failure scenarios are provided for each of the relevant failure modes. In addition, a failure methodology based upon the distribution of demand and the distribution of capacity for the structural members, with respect to each failure mode, is proffered.

  10. Safety culture in design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Macchi, L.; Pietikaeinen, E.; Liinasuo, M.; Savioja, P.; Reiman, T.; Wahlstroem, M. [VTT Technical Research Centre of Finland, Espoo (Finland); Kahlbom, U. [Risk Pilot AB, Stockholm (Sweden); Rollenhagen, C. [Vattenfall, Stockholm, (Sweden)

    2013-04-15

    In this report we approach design from a safety culture approach As this research area is new and understudied, we take a wide scope on the issue. Different theoretical perspectives that can be taken when improving safety of the design process are considered in this report. We suggest that in the design context the concept of safety culture should be expanded from an organizational level to the level of the network of organizations involved in the design activity. The implication of approaching the design process from a safety culture perspective are discussed and the results of the empirical part of the research are presented. In the interview study in Finland and Sweden we identified challenges and opportunities in the design process from safety culture perspective. Also, a small part of the interview study concentrated on state of the art human factors engineering (HFE) practices in Finland and the results relating to that are presented. This report provide a basis for future development of systematic good design practices and for providing guidelines that can lead to safe and robust technical solutions. (Author)

  11. Solar heating system final design package

    Science.gov (United States)

    1979-01-01

    The system is composed of a warm air collector, a logic control unit and a universal switching and transport unit. The collector was originally conceived and designed as an integrated roof/wall system and therefore provides a dual function in the structure. The collector serves both as a solar energy conversion system and as a structural weather resistant skin. The control unit provides totally automatic control over the operation of the system. It receives input data from sensor probes in collectors, storage and living space. The logic was designed so as to make maximum use of solar energy and minimize use of conventional energy. The transport and switching unit is a high-efficiency air-handling system equipped with gear motor valves that respond to outputs from the control system. The fan unit was designed for maximum durability and efficiency in operation, and has permanently lubricated ball bearings and excellent air-handling efficiency.

  12. 77 FR 3389 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2012-01-24

    ... Pollutants, State of West Virginia; Control of Emissions From Existing Hospital/Medical/Infectious Waste.... SUMMARY: EPA is taking direct final action to approve a revision to the West Virginia hospital/medical... plants, Waste treatment and disposal. Dated: January 5, 2012. W.C. Early, Acting Regional...

  13. 75 FR 12090 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-03-12

    .... SUMMARY: EPA proposes to approve a request from the State of Indiana to redesignate Lake and Porter... and Porter Counties and in the Chicago-Gary-Lake County, Illinois-Indiana (IL-IN) ozone nonattainment... ) emission inventories for Lake and Porter Counties as a revision of the Indiana SIP. Finally, EPA proposes...

  14. Tokamak blanket design study, final report

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    A cylindrical module concept was developed, analyzed, and incorporated in a tokamak blanket system that includes piping systems, vacuum boundary sealing, and support structures. The design is based on the use of state-of-the-art structural materials (20% cold-worked type 316 stainless steel), lithium as the breeding material, and pressurized helium as the coolant. The module design consists of nested concentric cylinders (with an outer diameter of 10 cm) and features direct wall cooling by helium flowing between the outer (first-wall) cylinder and the inner (lithium-containing) cylinder. Each cylinder can withstand full coolant pressure, thus enhancing reliability. Results show that stainless steel is a viable material for a first wall subjected to a neutron wall loading of 4 MW/m/sup 2/ and a particle heat flux of 1 MW/m/sup 2/. Lifetime analysis shows that the first-wall design meets the goal of operating at 20-min cycles with 95% duty for 100,000 cycles. To reduce system complexity, a larger 20-cm-diam module also was analyzed for incorporation in the blanket assembly. Reliability assessment indicates that it may be possible to double the module in size from 10 to 20 cm in diameter. With a modest increase in coolant pumping power, a blanket assembly comprising 20-cm-diam modules can still achieve 100,000 operating cycles - equivalent to a 3.6-year design lifetime - with only one or two helium coolant leaks into the plasma.

  15. Advanced Design Program (ARIES) Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Tillack, Mark [Univ. of California, San Diego, CA (United States)

    2016-02-16

    Progress is reported for the ARIES 3-year research program at UC San Diego, including three main tasks: 1. Completion of ARIES research on PMI/PFC issues. 2. Detailed engineering design and analysis of divertors and first wall/blankets. 3. Mission & requirements of FNSF.

  16. Solar heating system final design package

    Energy Technology Data Exchange (ETDEWEB)

    1979-05-01

    Contemporary Systems has taken its Series V Solar Heating System and developed it to a degree acceptable by local codes and regulatory agencies. The system is composed of the Series V warm air collector, the LCU-110 logic control unit and the USU-A universal switching and transport unit. The collector was originally conceived and designed as an integrated roof/wall system and provides a dual function in the structure. The collector serves both as a solar energy conversion system and as a structural weather resistant skin. The collector can be fabricated in any length from 12 to 24 feet. This provides maximum flexibility in design and installation. The LCU-110 control unit provides totally automatic control over the operation of the system. It receives input data from sensor probes in collectors, storage and living space. The logic is designed so as to make maximum use of solar energy and minimize use of conventional energy. The USU-A transport and switching unit is a high-efficiency air-handling system equipped with gear motor valves that respond to outputs from the control system. The fan unit is designed for maximum durability and efficiency in operation, and has permanently lubricated ball bearings and excellent air-handling efficiency.

  17. 49 CFR 107.402 - Application for designation as an approval or certification agency.

    Science.gov (United States)

    2010-10-01

    ... organization or person seeking designation as an approval or certification agency shall apply in writing to the... designation must be in English and include the following information: (1) Name and address of the applicant... with § 105.40 to serve as agent for service of process. (2) If the applicant's principal place...

  18. Final focus designs for crab waist colliders

    Science.gov (United States)

    Bogomyagkov, A.; Levichev, E.; Piminov, P.

    2016-12-01

    The crab waist collision scheme promises significant luminosity gain. The successful upgrade of the DA Φ NE collider proved the principle of crab waist collision and increased luminosity 3 times. Therefore, several new projects try to implement the scheme. The paper reviews interaction region designs with the crab waist collision scheme for already existent collider DA Φ NE and SuperKEKB, presently undergoing commissioning, for the projects of SuperB in Italy, CTau in Novosibirsk and FCC-ee at CERN.

  19. Final focus designs for crab waist colliders

    CERN Document Server

    AUTHOR|(CDS)2084369; Levichev, Evgeny; Piminov, Pavel

    2016-01-01

    The crab waist collision scheme promises significant luminosity gain. The successful upgrade of the DA$\\Phi$NE collider proved the principle of crab waist collision and increased luminosity 3 times. Therefore, several new projects try to implement the scheme. The paper reviews interaction region designs with the crab waist collision scheme for already existent collider DA$\\Phi$NE and SuperKEKB, presently undergoing commissioning, for the projects of SuperB in Italy, CTau in Novosibirsk and FCC-ee at CERN.

  20. ASCAD: Approved standard corrective action design-an innovative one-step remedial action plan

    Energy Technology Data Exchange (ETDEWEB)

    Hoffman, W.D.; Boyter, N.C.; Martin, D.K. [Westinghouse Savannah River Company, Aiken, SC (United States)

    1994-12-31

    This paper will describe an innovative environmental restoration approach being developed at the Savannah River Site to group sites, define characterization parameters, and match those conditions with standard environmental restoration designs. The package is called the Approved Standardized Corrective Action Design (ASCAD). The purpose of developing this package is to obtain regulator approval of standard technologies and designs for any waste site documented as meeting bounded characterization conditions. For instance, the grouping might be labeled {open_quotes}radioactive basins{close_quotes}. The ASCAD package would contain one design for expected (ABC) conditions defined by characterization. A second design also would be included for DEF conditions should they be encountered. The concept is a next generation of the Streamlined Approach for Environmental Restoration, SAFER where limited characterization and technology selections are conducted in parallel with the processes supporting each other. The impact of ASCAD is to reach remediation faster and lower costs on remedial investigation and design.

  1. 75 FR 27514 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-05-17

    ... three oxygen atoms, at the ground level is generally not emitted directly by sources such as from a... proceed with designations. The actions addressed in today's proposed rulemaking relate only to... standard.'' From the memorandum, section 4.b.i.). Today, EPA is also proposing to approve the 2002 base...

  2. 75 FR 54031 - Approval and Promulgation of Implementation Plans; Designation of Areas for Air Quality Planning...

    Science.gov (United States)

    2010-09-03

    ...; Designation of Areas for Air Quality Planning Purposes; State of California; PM-10; Redesignation of the Coso Junction Planning Area to Attainment; Approval of PM-10 Maintenance Plan for the Coso Junction Planning... State of California's request to redesignate the Coso Junction planning area (CJPA) to attainment for...

  3. K Basin sludge packaging design criteria (PDC) and safety analysis report for packaging (SARP) approval plan

    Energy Technology Data Exchange (ETDEWEB)

    Brisbin, S.A.

    1996-03-06

    This document delineates the plan for preparation, review, and approval of the Packaging Design Crieteria for the K Basin Sludge Transportation System and the Associated on-site Safety Analysis Report for Packaging. The transportation system addressed in the subject documents will be used to transport sludge from the K Basins using bulk packaging.

  4. Revised guideline for the approval procedure of package designs in Germany

    Energy Technology Data Exchange (ETDEWEB)

    Nitsche, F. [Federal Office for Radiation Protection, Salzgitter (Germany); Roedel, R. [Federal Inst. for Materials Research and Testing, Berlin (Germany)

    2004-07-01

    The IAEA Regulations for the Safe Transport of Radioactive Material, TS-R-1 are applied in Germany through the implementation of the Dangerous Goods Transport Regulations for class 7 of the International Modal Organisations (ADR, RID, IMDG-Code, ICAO-TI). Based on this the approval procedures for packages designs applied in Germany are in compliance with the provisions of TS-R-1. The Guideline R 003 issued by the Ministry of Transport, Building and Housing (BMVBW) in 1991 is the basis for the package design approval procedures in Germany. This Guideline has been reviewed and revised to reflect latest developments in the regulations as well as in the regulatory practice. In particular it has been extended to the approval procedures of Type C packages, packages subject to transitional arrangements, special form and low dispersible radioactive material and provides more detailed information to the applicant about the requested documentation. Publication of this revised guideline has been delayed but it is expected to take place in October 2004. The paper gives an overview about the main parts and provisions of this revised Guideline R 003 with the focus on package design approval procedures.

  5. 14 CFR 193.17 - How must design and production approval holders handle information they receive from the FAA...

    Science.gov (United States)

    2010-01-01

    ... REGULATIONS PROTECTION OF VOLUNTARILY SUBMITTED INFORMATION § 193.17 How must design and production approval... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false How must design and production approval holders handle information they receive from the FAA under this part? 193.17 Section 193.17...

  6. Delfi-N3XT; final design and production

    NARCIS (Netherlands)

    Bouwmeester, J.

    2011-01-01

    Delfi-n3Xt, the second university satellite of TU Delft, is scheduled for launch in the last quarter of 2012. The development team is currently active in finalizing the design and building an engineering model which should be finished by the end of 2011. In this article the latest design is presente

  7. Novel final focus design for future linear colliders.

    Science.gov (United States)

    Raimondi, P; Seryi, A

    2001-04-23

    The length, complexity, and cost of the present final focus designs for linear colliders grow very quickly with the beam energy. In this Letter, a novel final focus system is presented and compared with the one proposed for the Next Linear Collider (NLC Zeroth-Order Design Report, edited by T. O. Raubenheimer, SLAC Report No. 474, 1996). This new design has fewer optical elements and is much shorter, nonetheless achieving better chromatic properties. Moreover, the new system is more suitable for operation over a larger energy range.

  8. Optimal Final Carry Propagate Adder Design for Parallel Multipliers

    CERN Document Server

    B., Ramkumar

    2011-01-01

    Based on the ASIC layout level simulation of 7 types of adder structures each of four different sizes, i.e. a total of 28 adders, we propose expressions for the width of each of the three regions of the final Carry Propagate Adder (CPA) to be used in parallel multipliers. We also propose the types of adders to be used in each region that would lead to the optimal performance of the hybrid final adders in parallel multipliers. This work evaluates the complete performance of the analyzed designs in terms of delay, area, power through custom design and layout in 0.18 um CMOS process technology.

  9. Final system instrumentation design package for Decade 80 solar house

    Science.gov (United States)

    1978-01-01

    The final configuration of the Decade 80 solar house to monitor and collect system performance data is presented. A review demonstrated by actual operation that the system and the data acquisition subsystem operated satisfactorily and installation of instrumentation was in accordance with the design. This design package is made up of (1) site and system description, (2) operating and control modes, and (3) instrumentation program (including sensor schematic).

  10. ‘Kunstbloem’ in finale Bio-Art & Design

    NARCIS (Netherlands)

    Kleis, R.; Kleijn, D.

    2015-01-01

    Hoe ziet het landschap eruit als bijen op een kunstbloem met gekleurde pollen foerageren? Als een Van Gogh? Het idee levert onderzoeker David Kleijn een plek op in de finale van de Bio-Art & Design competitie. Synthetic Pollinizer heet het project dat Kleijn samen met de Australische kunstenaar

  11. SIAM Conference on Geometric Design and Computing. Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2002-03-11

    The SIAM Conference on Geometric Design and Computing attracted 164 domestic and international researchers, from academia, industry, and government. It provided a stimulating forum in which to learn about the latest developments, to discuss exciting new research directions, and to forge stronger ties between theory and applications. Final Report

  12. Final design and construction of the Wendelstein7-X coils

    Energy Technology Data Exchange (ETDEWEB)

    Wegener, L. E-mail: lutz.wegener@ipp.mpg.de; Feist, J.-H.; Sapper, J.; Kerl, F.; Werner, F

    2001-11-01

    The Stellarator of the Wendelstein 7-X (W7-X) experiment contains a system of 50 non-planar and 20 planar superconducting coils. The coils were designed by the IPP. The coil manufacturing and inspection is shared between several European enterprises and consortiums. The coils consist of the winding pack embedded in a stainless steel casing and of the related instrumentation. Design details, tolerances and guarantee values and differences between the coils types are described in the contribution. The features of the superconductor are described separately. Finally, the contribution indicates measures adopted by the W7-X project to ensure the quality of the coil design and manufacturing.

  13. Final design of the beam source for the MITICA injector

    Energy Technology Data Exchange (ETDEWEB)

    Marcuzzi, D., E-mail: diego.marcuzzi@igi.cnr.it; Agostinetti, P.; Dalla Palma, M.; De Muri, M.; Chitarin, G.; Gambetta, G.; Marconato, N.; Pasqualotto, R.; Pavei, M.; Pilan, N.; Rizzolo, A.; Serianni, G.; Toigo, V.; Trevisan, L.; Visentin, M.; Zaccaria, P.; Zaupa, M. [Consorzio RFX, Corso Stati Uniti, 4, I-35127 Padova (Italy); Boilson, D.; Graceffa, J.; Hemsworth, R. S. [ITER Organization, Route de Vinon-sur-Verdon, 13067 St Paul Lez Durance (France); and others

    2016-02-15

    The megavolt ITER injector and concept advancement experiment is the prototype and the test bed of the ITER heating and current drive neutral beam injectors, currently in the final design phase, in view of the installation in Padova Research on Injector Megavolt Accelerated facility in Padova, Italy. The beam source is the key component of the system, as its goal is the generation of the 1 MeV accelerated beam of deuterium or hydrogen negative ions. This paper presents the highlights of the latest developments for the finalization of the MITICA beam source design, together with a description of the most recent analyses and R&D activities carried out in support of the design.

  14. Final design of the beam source for the MITICA injector

    Science.gov (United States)

    Marcuzzi, D.; Agostinetti, P.; Dalla Palma, M.; De Muri, M.; Chitarin, G.; Gambetta, G.; Marconato, N.; Pasqualotto, R.; Pavei, M.; Pilan, N.; Rizzolo, A.; Serianni, G.; Toigo, V.; Trevisan, L.; Visentin, M.; Zaccaria, P.; Zaupa, M.; Boilson, D.; Graceffa, J.; Hemsworth, R. S.; Choi, C. H.; Marti, M.; Roux, K.; Singh, M. J.; Masiello, A.; Froeschle, M.; Heinemann, B.; Nocentini, R.; Riedl, R.; Tobari, H.; de Esch, H. P. L.; Muvvala, V. N.

    2016-02-01

    The megavolt ITER injector and concept advancement experiment is the prototype and the test bed of the ITER heating and current drive neutral beam injectors, currently in the final design phase, in view of the installation in Padova Research on Injector Megavolt Accelerated facility in Padova, Italy. The beam source is the key component of the system, as its goal is the generation of the 1 MeV accelerated beam of deuterium or hydrogen negative ions. This paper presents the highlights of the latest developments for the finalization of the MITICA beam source design, together with a description of the most recent analyses and R&D activities carried out in support of the design.

  15. Planning and initiation of detailed engineering design for the Great Plains coal gasification project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1980-01-01

    During the course of detailed engineering it was expected that preliminary engineering documents would need to be modified. In a number of instances, however, especially for flow diagrams and specifications, the revised preliminary engineering documents became the final approved for construction (AFC) documents. P and ID's and plot plans were updated as a result of the detailed piping design. Equipment data sheets which initially contained basic process data were made mechanically complete and then further updated to reflect the equipment actually purchased. The initial issue of the preliminary engineering documents represent a necessary baseline for monitoring project design changes. Foundation work, equipment specifications and status of engineering in the various process operations are discussed.

  16. Obinutuzumab for chronic lymphocytic leukemia: promise of the first treatment approved with breakthrough therapy designation.

    Science.gov (United States)

    Kakkar, Ashish Kumar; Balakrishnan, Sadasivam

    2015-10-01

    Obinutuzumab (also known as GA101, afutuzumab, Gazyva) is a humanized, glycoengineered type II monoclonal antibody targeted against CD20. The US Food and Drug Administration has approved obinutuzumab for use with chlorambucil in patients with previously untreated chronic lymphocytic leukemia. The drug is the first treatment to receive approval under the agency's breakthrough therapy designation, a program intended to facilitate and expedite the review and development of therapies for serious and life-threatening conditions. In preclinical studies, obinutuzumab has showed superior efficacy, as compared with rituximab, by inducing direct cell death and increased antibody-dependent cellular cytotoxicity activity with less complement-dependent cytotoxicity. Regulatory approval of obinutuzumab is based on a phase III (CLL11) study that demonstrated improved outcomes with a combination of obinutuzumab with chlorambucil in previously untreated patients with chronic lymphocytic leukemia and comorbidities. Obinutuzumab plus chlorambucil induced deeper and longer remissions than rituximab plus chlorambucil combination as evidenced by prolongation of progression-free survival and higher complete response and molecular response rates. Marketing applications for obinutuzumab have also been submitted to other regulatory authorities including the European Medicines Agency.

  17. DIME Students Discuss Final Drop Tower Experiment Design

    Science.gov (United States)

    2002-01-01

    Students discuss fine points of their final design for the Drop Tower experiment during the second Dropping in a Microgravity Environment (DIME) competition held April 23-25, 2002, at NASA's Glenn Research Center. Competitors included two teams from Sycamore High School, Cincinnati, OH, and one each from Bay High School, Bay Village, OH, and COSI Academy, Columbus, OH. DIME is part of NASA's education and outreach activities. Details are on line at http://microgravity.grc.nasa.gov/DIME_2002.html.

  18. LCLS XTOD Tunnel Vacuum Transport System (XVTS) Final Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Shen, S

    2006-10-16

    The design of the X-Ray Vacuum Transport System (XVTS) for the Linac Coherent Light Source (LCLS) X-ray Transport, Optics and Diagnostics (XTOD) system has been analyzed and configured by the Lawrence Livermore National Laboratory's New Technologies Engineering Division (NTED) as requested by the SLAC/LCLS program. A preliminary design review was held on 11/14/05 [1][2]. This FDR (Final Design Report) presents system configuration, detailed analyses and selection of the mechanical and electrical components for the XTOD tunnel section, as well as the response to all issues raised in the review committee report. Also included are the plans for procurement, mechanical integration, schedule and the cost estimates. It should be noticed that, after the XVTS PDR, LCLS management has decided to lower the number of beamlines from three to one, and shorten the tunnel length from 212 m to 184 m. [3][4] The final design of XVTS system is completed. The major subjects presented in this report are: (1) Design of the complete system. (2) System analysis results. (3) ES&H issues and plan. (4) Project cost estimates and schedule.

  19. Safety regulation for the design approval of special form radioactive sources

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Woon-Kap [Korea Institute of Nuclear Safety (KINS), Guseong-dong 19, Yuseong, Daejeon 305-338 (Korea, Republic of)], E-mail: wkcho@kins.re.kr

    2009-07-15

    Several kinds of special form radioactive sources for industrial, medical applications are being produced in Korea. Special form radioactive sources should meet strict safety requirements specified in the domestic safety regulations and the design of the sources should be certified by the regulatory authority, the Ministry of Education, Science and Technology (MEST). Several safety tests such as impact, percussion, heating, and leak tests are performed on the sources according to the domestic regulations and the international safety standards such as ANSI N542-1977 and ISO 2919-1999(E). As a regulatory expert body, Korea Institute of Nuclear Safety (KINS) assesses various types of application documents, such as safety analysis report, quality assurance program, and other documents evidencing fulfillment of requirements for design approval of the special form radioactive sources, submitted by a legal person who intends to produce special form radioactive sources and then reports the assessment result to MEST. A design approval certificate is issued to the applicant by MEST on the basis of a technical evaluation report presented by KINS.

  20. Innovative design approaches for large wind turbine blades : final report.

    Energy Technology Data Exchange (ETDEWEB)

    2004-05-01

    The goal of the Blade System Design Study (BSDS) was investigation and evaluation of design and manufacturing issues for wind turbine blades in the one to ten megawatt size range. A series of analysis tasks were completed in support of the design effort. We began with a parametric scaling study to assess blade structure using current technology. This was followed by an economic study of the cost to manufacture, transport and install large blades. Subsequently we identified several innovative design approaches that showed potential for overcoming fundamental physical and manufacturing constraints. The final stage of the project was used to develop several preliminary 50m blade designs. The key design impacts identified in this study are: (1) blade cross-sections, (2) alternative materials, (3) IEC design class, and (4) root attachment. The results show that thick blade cross-sections can provide a large reduction in blade weight, while maintaining high aerodynamic performance. Increasing blade thickness for inboard sections is a key method for improving structural efficiency and reducing blade weight. Carbon/glass hybrid blades were found to provide good improvements in blade weight, stiffness, and deflection when used in the main structural elements of the blade. The addition of carbon resulted in modest cost increases and provided significant benefits, particularly with respect to deflection. The change in design loads between IEC classes is quite significant. Optimized blades should be designed for each IEC design class. A significant portion of blade weight is related to the root buildup and metal hardware for typical root attachment designs. The results show that increasing the number of blade fasteners has a positive effect on total weight, because it reduces the required root laminate thickness.

  1. Conceptual designs for modular OTEC SKSS. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-02-29

    This volume presents the results of the first phase of the Station Keeping Subsystem (SKSS) design study for 40 MW/sub e/ capacity Modular Experiment OTEC Platforms. The objectives of the study were: (1) establishment of basic design requirements; (2) verification of technical feasibility of SKSS designs; (3) identification of merits and demerits; (4) estimates of sizes for major components; (5) estimates of life cycle costs; (6) deployment scenarios and time/cost/risk assessments; (7) maintenance/repair and replacement scenarios; (8) identifications of interface with other OTEC subsystems; (9) recommendations for and major problems in preliminary design; and (10) applicability of concepts to commercial plant SKSS designs. A brief site suitability study was performed with the objective of determining the best possible location at the Punta Tuna (Puerto Rico) site from the standpoint of anchoring. This involved studying the vicinity of the initial location in relation to the prevailing bottom slopes and distances from shore. All subsequent studies were performed for the final selected site. The two baseline OTEC platforms were the APL BARGE and the G and C SPAR. The results of the study are presented in detail. The overall objective of developing two conceptual designs for each of the two baseline OTEC platforms has been accomplished. Specifically: (1) a methodology was developed for conceptual designs and followed to the extent possible. At this stage, a full reliability/performance/optimization analysis based on a probabilistic approach was not used due to the numerous SKSS candidates to be evaluated. A deterministic approach was used. (2) For both of the two baseline platforms, the APL BARGE and the G and C SPAR, all possible SKSS candidate concepts were considered and matrices of SKSS concepts were developed.

  2. Further development of public participation in the site-selection and approval process of a final repository in Germany

    Energy Technology Data Exchange (ETDEWEB)

    Barth, Regine; Kallenbach-Herbert, Beate [OeEo-Institute e.V., Inst. for Applied Ecology, Darmstadt (Germany); Arens, Georg [Federal Office for Radiation Protection (BfS), Salzgitter (Germany)

    2006-09-15

    This paper reflects the first findings of a current research project funded by the German Federal Office for Radiation Protection and conducted by an interdisciplinary working group of the OEko-Institute. One focus of this project is the systematic analysis of past and existing participatory processes in different nuclear and non-nuclear projects. On the basis of this analysis and a literature review a specific concept for public participation in the site-selection and approval process of a repository for high radioactive waste (HAW repository) in Germany will be derived. The concept shall foster transparency and acceptance. The working group of the OEko-Institute combines long standing research experience and an intimate knowledge of radioactive waste management including political, technical, management and social problems of final disposal on the one hand. On the other hand members play an active role in stakeholder processes of different non-nuclear projects as well as experience with a wide range of participative measures and their impact. This allows an approach which integrates the specific features of radioactive waste disposal with a wider perspective on the demands and opportunities of stakeholder processes. The procedure of site selection for a HAW repository in Germany still has to be specified. The procedure introduced by the 'Committee on a Site Selection Procedure for Repository Sites' (Arbeitskreis Auswahlverfahren Endlagerstandorte - AkEnd) has not been adopted. The Committee had suggested installing a negotiation group to discuss the AkEnd proposals in the so called 'Phase II'. This suggestion could not be followed because not all relevant stakeholders were willing to participate. An internal draft for a federal law implementing main elements of the AkEnd findings was developed by the Ministry for Environment in 2005, but has never been brought to the cabinet. Due to the change of Government in Germany, the next steps still are

  3. FERMI@Elettra FEL Design Technical Optimization Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Fawley, William; Penn, Gregory; Allaria, Enrico; De Ninno,Giovanni; Graves, William

    2006-07-31

    This is the final report of the FEL Design Group for the Technical Optimization Study for the FERMI{at}ELETTRA project. The FERMI{at}ELETTRA project is based on the principle of harmonic upshifting of an initial ''seed'' signal in a single pass, FEL amplifier employing multiple undulators. There are a number of FEL physics principles which underlie this approach to obtaining short wavelength output: (1) the energy modulation of the electron beam via the resonant interaction with an external laser seed (2) the use of a chromatic dispersive section to then develop a strong density modulation with large harmonic overtones (3) the production of coherent radiation by the microbunched beam in a downstream radiator. Within the context of the FERMI project, we discuss each of these elements in turn.

  4. Final design of thermal diagnostic system in SPIDER ion source

    Science.gov (United States)

    Brombin, M.; Dalla Palma, M.; Pasqualotto, R.; Pomaro, N.

    2016-11-01

    The prototype radio frequency source of the ITER heating neutral beams will be first tested in SPIDER test facility to optimize H- production, cesium dynamics, and overall plasma characteristics. Several diagnostics will allow to fully characterise the beam in terms of uniformity and divergence and the source, besides supporting a safe and controlled operation. In particular, thermal measurements will be used for beam monitoring and system protection. SPIDER will be instrumented with mineral insulated cable thermocouples, both on the grids, on other components of the beam source, and on the rear side of the beam dump water cooled elements. This paper deals with the final design and the technical specification of the thermal sensor diagnostic for SPIDER. In particular the layout of the diagnostic, together with the sensors distribution in the different components, the cables routing and the conditioning and acquisition cubicles are described.

  5. Final design of thermal diagnostic system in SPIDER ion source

    Energy Technology Data Exchange (ETDEWEB)

    Brombin, M., E-mail: matteo.brombin@igi.cnr.it; Dalla Palma, M.; Pasqualotto, R.; Pomaro, N. [Consorzio RFX, Corso Stati Uniti 4, I-35127 Padova (Italy)

    2016-11-15

    The prototype radio frequency source of the ITER heating neutral beams will be first tested in SPIDER test facility to optimize H{sup −} production, cesium dynamics, and overall plasma characteristics. Several diagnostics will allow to fully characterise the beam in terms of uniformity and divergence and the source, besides supporting a safe and controlled operation. In particular, thermal measurements will be used for beam monitoring and system protection. SPIDER will be instrumented with mineral insulated cable thermocouples, both on the grids, on other components of the beam source, and on the rear side of the beam dump water cooled elements. This paper deals with the final design and the technical specification of the thermal sensor diagnostic for SPIDER. In particular the layout of the diagnostic, together with the sensors distribution in the different components, the cables routing and the conditioning and acquisition cubicles are described.

  6. Final design and choices for EUCLID NISP grism

    Science.gov (United States)

    Costille, A.; Caillat, A.; Rossin, C.; Pascal, S.; Sanchez, P.; Foulon, B.; Vives, S.

    2016-07-01

    ESA Euclid mission is designed to map the geometry of the dark Universe. The NISP (Near Infrared Spectro- Photometer) is one of its two instruments dedicated to NIR with two main observing modes: the photometric mode and the spectroscopic mode, for the acquisition of slitless dispersed images using four low resolution grisms: three "red" grisms for 1250-1850nm, and one "blue" grism for 920-1300nm. The NISP grisms are complex optical components that combine four main functions: a grism done by the grating on the prism hypotenuse, a spectral filter done by a multilayer filter deposited on the first surface of the prism, a focus function done by a curved surface and a spectral wavefront correction done by the grating with curved grooves. This specific grating is made thanks to a new technic developed with SILIOS Technologies to manufacture a resin-free grating. The optical component is glued onto a mechanical ring, designed to survive to 60g DLL and to keep optical performance at 130K. The design and manufacturing of these components represent an important challenge to obtain the best performances with very constraining requirements. We will present the performance obtained on scale-1 prototypes of the filter, the grating and the mount manufactured to validate the final design choices and used to make the necessary trade-off during the development phase. All the prototypes have shown very good optical performances and have withstood vibrations and vacuum cryogenic tests that confirm the feasibility of NISP grisms and prepare the next phase for the procurement and tests of NISP grism flight models.

  7. Variable-Speed Wind System Design : Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Lauw, Hinan K.; Weigand, Claus H.; Marckx, Dallas A.; Electronic Power Conditioning, Inc.

    1993-10-01

    Almost from the onset of the development of wind energy conversion systems (WECS), it was known that variable-speed operation of the turbine would maximize energy capture. This study was commissioned to assess the cost, efficiency gain, reduction of the cost of energy (COE), and other operating implications of converting the existing hardware of a modern fixed-speed wind energy conversion system to variable-speed operation. The purpose of this study was to develop a preliminary design for the hardware required to allow variable-speed operation using a doubly-fed generator with an existing fixed-speed wind turbine design. The turbine selected for this study is the AWT-26 designed and built by Advanced Wind Turbines Inc. of Redmond, Washington. The lowest projected COE using this variable-speed generation system is projected to be $0.0499/kWh, compared to the lowest possible COE with fixed-speed generation which is projected to be $0.0546/kWh. This translates into a 8.6% reduction of the COE using this variable-speed generation option. The preliminary system design has advanced to where the printed circuit boards can be physically laid out based on the schematics and the system software can be written based on the control flow-charts. The core of hardware and software has been proven to be successful in earlier versions of VSG systems. The body of this report presents the results of the VSWG system development. Operation under normal and fault conditions is described in detail, the system performance for variable-speed operation is estimated and compared to the original fixed-speed system performance, and specifications for all system components (generator, power electronic converter, and system controller) are given. Costs for all components are estimated, and incremental system cost is compared to incremental energy production. Finally, operational features of the VSWG which are not available in the existing FSWG system are outlined.

  8. Northeast Oregon Hatchery Project, Conceptual Design Report, Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Watson, Montgomery (Montgomery Watson, Bellevue, WA)

    1995-03-01

    This report presents the results of site analysis for the Bonneville Power Administration Northeast Oregon Hatchery Project. The purpose of this project is to provide engineering services for the siting and conceptual design of hatchery facilities for the Bonneville Power Administration. The hatchery project consists of artificial production facilities for salmon and steelhead to enhance production in three adjacent tributaries to the Columbia River in northeast Oregon: the Grande Ronde, Walla Walla, and Imnaha River drainage basins. Facilities identified in the master plan include adult capture and holding facilities; spawning incubation, and early rearing facilities; full-term rearing facilities; and direct release or acclimation facilities. The evaluation includes consideration of a main production facility for one or more of the basins or several smaller satellite production facilities to be located within major subbasins. The historic and current distribution of spring and fall chinook salmon and steelhead was summarized for the Columbia River tributaries. Current and future production and release objectives were reviewed. Among the three tributaries, forty seven sites were evaluated and compared to facility requirements for water and space. Site screening was conducted to identify the sites with the most potential for facility development. Alternative sites were selected for conceptual design of each facility type. A proposed program for adult holding facilities, final rearing/acclimation, and direct release facilities was developed.

  9. Northeast Oregon Hatchery Project, Conceptual Design Report, Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Watson, Montgomery (Montgomery Watson, Bellevue, WA)

    1995-03-01

    This report presents the results of site analysis for the Bonneville Power Administration Northeast Oregon Hatchery Project. The purpose of this project is to provide engineering services for the siting and conceptual design of hatchery facilities for the Bonneville Power Administration. The hatchery project consists of artificial production facilities for salmon and steelhead to enhance production in three adjacent tributaries to the Columbia River in northeast Oregon: the Grande Ronde, Walla Walla, and Imnaha River drainage basins. Facilities identified in the master plan include adult capture and holding facilities; spawning incubation, and early rearing facilities; full-term rearing facilities; and direct release or acclimation facilities. The evaluation includes consideration of a main production facility for one or more of the basins or several smaller satellite production facilities to be located within major subbasins. The historic and current distribution of spring and fall chinook salmon and steelhead was summarized for the Columbia River tributaries. Current and future production and release objectives were reviewed. Among the three tributaries, forty seven sites were evaluated and compared to facility requirements for water and space. Site screening was conducted to identify the sites with the most potential for facility development. Alternative sites were selected for conceptual design of each facility type. A proposed program for adult holding facilities, final rearing/acclimation, and direct release facilities was developed.

  10. 78 FR 68687 - Final Additional Airworthiness Design Standards: Advanced Avionics Under the Special Class (JAR...

    Science.gov (United States)

    2013-11-15

    ... Administration 14 CFR Part 21 Final Additional Airworthiness Design Standards: Advanced Avionics Under the... document is an issuance of the final airworthiness design criteria for the inclusion of advance...

  11. Final focus shielding designs for modern heavy-ion fusion power plant designs

    Science.gov (United States)

    Latkowski, J. F.; Meier, W. R.

    2001-05-01

    Recent work in heavy-ion fusion accelerators and final focusing systems shows a trend towards less current per beam, and thus, a greater number of beams. Final focusing magnets are susceptible to nuclear heating, radiation damage, and neutron activation. The trend towards more beams, however, means that there can be less shielding for each magnet. Excessive levels of nuclear heating may lead to magnet quench or to an intolerable recirculating power for magnet cooling. High levels of radiation damage may result in short magnet lifetimes and low reliability. Finally, neutron activation of the magnet components may lead to difficulties in maintenance, recycling, and waste disposal. The present work expands upon previous, three-dimensional magnet shielding calculations for a modified version of the HYLIFE-II IFE power plant design. We present key magnet results as a function of the number of beams.

  12. Final Focus Shielding Designs for Modern Heavy-Ion Fusion Power Plant Designs

    Energy Technology Data Exchange (ETDEWEB)

    Latkowski, J F; Meier, W R

    2000-07-05

    Recent work in heavy-ion fusion accelerators and final focusing systems shows a trend towards less current per beam, and thus, a greater number of beams. Final focusing magnets are susceptible to nuclear heating, radiation damage, and neutron activation. The trend towards more beams, however, means that there can be less shielding for each magnet, Excessive levels of nuclear heating may lead to magnet quench or an intolerable recirculating power for magnet cooling. High levels of radiation damage may result in short magnet lifetimes and low reliability. Finally, neutron activation of the magnet components may lead to difficulties in maintenance, recycling, and waste disposal. The present work expands upon previous, three-dimensional magnet shielding calculations for a modified version of the HYLIFE-I1 IFE power plant design. We present key magnet results as a function of the number of beams.

  13. Waste Isolation Pilot Plant design validation: Final report

    Energy Technology Data Exchange (ETDEWEB)

    1986-10-01

    This report provides documentation of actual underground conditions encountered as they relate to the design criteria, design bases, and design configurations for the reference design of the underground openings. It includes a selection of the more essential data collected during the design validation effort and an interpretation of these data.

  14. Final Design Report for the RH LLW Disposal Facility (RDF) Project

    Energy Technology Data Exchange (ETDEWEB)

    Austad, S. L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-05-01

    The RH LLW Disposal Facility (RDF) Project was designed by AREVA Federal Services (AFS) and the design process was managed by Battelle Energy Alliance (BEA) for the Department of Energy (DOE). The final design report for the RH LLW Disposal Facility Project is a compilation of the documents and deliverables included in the facility final design.

  15. Final Design Report for the RH LLW Disposal Facility (RDF) Project

    Energy Technology Data Exchange (ETDEWEB)

    Austad, Stephanie Lee [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    The RH LLW Disposal Facility (RDF) Project was designed by AREVA Federal Services (AFS) and the design process was managed by Battelle Energy Alliance (BEA) for the Department of Energy (DOE). The final design report for the RH LLW Disposal Facility Project is a compilation of the documents and deliverables included in the facility final design.

  16. Final Design Report for the RH LLW Disposal Facility (RDF) Project

    Energy Technology Data Exchange (ETDEWEB)

    Austad, Stephanie Lee [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-09-01

    The RH LLW Disposal Facility (RDF) Project was designed by AREVA Federal Services (AFS) and the design process was managed by Battelle Energy Alliance (BEA) for the Department of Energy (DOE). The final design report for the RH LLW Disposal Facility Project is a compilation of the documents and deliverables included in the facility final design.

  17. 48 CFR 252.227-7024 - Notice and approval of restricted designs.

    Science.gov (United States)

    2010-10-01

    ... structures, machines, products, materials, construction methods, and equipment that are readily available through Government or competitive commercial channels, or through standard or proven production techniques, methods, and processes. Unless approved by the Contracting Officer, the Contractor shall not produce...

  18. 1-MWE heat exchangers for OTEC. Final design report

    Energy Technology Data Exchange (ETDEWEB)

    Sprouse, A.M.

    1980-06-19

    The design of a 1 MWe OTEC heat exchanger is documented, including the designs of the evaporator and associated systems, condenser, instrumentation, and materials for corrosion/erosion control and fabrication processes. (LEW)

  19. Post-Approval Studies

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CDRH Post-Approval Studies Program encompasses design, tracking, oversight, and review responsibilities for studies mandated as a condition of approval of a...

  20. Knowledge and Processes in Design. DPS Final Report.

    Science.gov (United States)

    Pirolli, Peter

    Four papers from a project concerning information-processing characterizations of the knowledge and processes involved in design are presented. The project collected and analyzed verbal protocols from instructional designers, architects, and mechanical engineers. A framework was developed for characterizing the problem spaces of design that…

  1. The effect size, study design, and development experience in commercially sponsored studies for new drug applications in approved drugs

    OpenAIRE

    Fukunaga, Satoshi; Kusama, Makiko; Ono, Shunsuke

    2014-01-01

    Pharmaceutical companies incorporate different features into the trials for new drug applications (NDAs) to render them efficient, making use of their experience. The objective of this analysis was to examine the associations between outcome and features related to study design and clinical development experience in commercially sponsored clinical trials. We collected data of phase 2 and phase 3 trials of all the drugs that obtained approval for depression, schizophrenia, asthma, hypertension...

  2. Development of the ITER Continuous External Rogowski: From conceptual design to final design

    Energy Technology Data Exchange (ETDEWEB)

    Moreau, Philippe, E-mail: philippe.jacques.moreau@cea.fr [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Spuig, Pascal; Le-luyer, Alain; Malard, Philippe; Cantone, Bruno; Pastor, Patrick; Saint-Laurent, François [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Vayakis, George; Delhom, Dominique [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); Arshad, Shakeib [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Lister, Jonathan; Toussaint, Matthieu; Marmillod, Philippe; Testa, Duccio; Schlatter, Christian [Ecole polytechnique fédérale de Lausanne, Centre de Recherches en Physique des Plasmas, 1015 Lausanne (Switzerland); Peruzzo, Simone [Consorzio RFX, C.so Stati Uniti 4, 35127 Padova (Italy)

    2015-10-15

    Highlights: • ITER Continuous External Rogowskis are designed for plasma current measurement. • CER are located in the casing of Toroidal Field Coils and will operate at 4.5 K. • The design of the sensors has been completed and validated through prototypes. • Detailed assembly procedure inside the toroidal field coil casing has been defined. • The CER has passed all the ITER and F4E design review procedures. - Abstract: In ITER, an accurate measurement of plasma current, with high reliability, is mandatory as this parameter is used to demonstrate licensing compliance with regulatory limits. For that purpose, several independent measurements based on magnetic diagnostics have been proposed. Rogowski coils are standard inductive sensors for current measurement in many applications. In ITER, three continuous external Rogowski coils are to be installed in the casing of the toroidal field coils. These sensors are remarkable from several points of view: overall length is about 40 m, high sensitivity needed, located in the toroidal field coil casing at 4.5 K and complex 3D routing with tight bending radius of 50 mm. Since 2005 an extensive work has been carried out to develop and analyze several design options complying with ITER specifications. Prototypes of a selected continuous external Rogowski design were built and tested successfully in terms of electrical, thermal, mechanical and vacuum characteristics. Finally a detailed assembly procedure inside the toroidal field coil casing has been defined according to the coil manufacturing and assembly constraints.

  3. CHIMERA CBRN protective suit. Advanced embodiment design. Final report

    NARCIS (Netherlands)

    Bogerd, C.P.; Smit, B. de; Olarte, C.; Kane, G.; Bie, M. de; Megen, X. van; Schenk, J.; Hooop, J. de

    2015-01-01

    The Chimera project started of with the following design challenge: Designing a switchable CBRN (chemical, biological, radiological, nuclear) protective suit for soldiers, one phase being a regular work state and the other phase being a protective state to enable the soldier to get away from the tox

  4. CHIMERA CBRN protective suit. Advanced embodiment design. Final report

    NARCIS (Netherlands)

    Bogerd, C.P.; Smit, B. de; Olarte, C.; Kane, G.; Bie, M. de; Megen, X. van; Schenk, J.; Hooop, J. de

    2015-01-01

    The Chimera project started of with the following design challenge: Designing a switchable CBRN (chemical, biological, radiological, nuclear) protective suit for soldiers, one phase being a regular work state and the other phase being a protective state to enable the soldier to get away from the

  5. LWR design decision methodology: Phase II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-01-01

    Techniques were identified to augment existing design process at the component and system level in order to optimize cost and safety between alternative system designs. The method was demonstrated using the Surry Low Pressure Injection System (LPIS). Three possible backfit options were analyzed for the Surry LPIS, assessing the safety level of each option and estimating the acquisition and installation costs for each. (DLC)

  6. 75 FR 44734 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-07-29

    .... Reasonable Available Control Measures/Control Technology d. Emission Inventory e. Permits for New and... Fully Approved Maintenance Plan Under CAA Section 175A 1. Attainment Inventory 2. Maintenance... natural vehicle turnover (i.e., replacement of older more polluting motor vehicles with newer cleaner...

  7. 76 FR 12587 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2011-03-08

    ... vessels, locomotives and aircraft emissions from other non-road emission sources. See 75 FR 62039. EPA... Cocke County. MLA = Commercial Marine Vessels, Locomotives and Aircraft. Table 4--Knoxville Area VOC... volatile organic compounds (VOC). This action also approves the emissions inventory submitted with...

  8. 77 FR 3422 - Approval and Promulgation of State Air Quality Plans for Designated Facilities and Pollutants...

    Science.gov (United States)

    2012-01-24

    ...; State of West Virginia; Control of Emissions From Existing Hospital/Medical/Infectious Waste Incinerator... proposes to approve a revision to the West Virginia hospital/medical/infectious waste incinerator (HMIWI) Section 111(d)/ 129 plan (the ``plan''). The revision contains a modified state rule for solid...

  9. 77 FR 6727 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2012-02-09

    ...., Monday through Friday, excluding Federal holidays. We recommend that you telephone Kathleen D'Agostino...: Kathleen D'Agostino, Environmental Engineer, Attainment Planning and Maintenance Section, Air Programs... redesignation under section 107(d)(3)(E) of the CAA. EPA is thus proposing to approve Wisconsin's requests...

  10. Passive design for a manufactured classroom building. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1981-03-31

    Work conducted by Madison Industries Inc. of Georgia and the Georgia Institute of Technology Engineering Experiment Station toward the development of passive solar heating systems for manufactured buildings is summarized. The specific application is a modular classroom building. Four passive system concepts were selected for space heating. These concepts are as follows: (1) direct gain; (2) water wall; (3) sunspace; and (4) integral collector wall. Designs were prepared for all four concepts. Thermal analyses were conducted, including annual heating simulations, for all designs. Typical weather and solar data for Atlanta were used in the simulations. In addition, design features for daylighting were incorporated in the building.

  11. Abrams Primary School passive solar design. Phase 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-01-01

    The general project documentation and the design process documentation for the project are presented. The following are appended: analysis of thermal transfer and internal heat contributions to the heating and cooling loads for a typical four-classroom teaching module using bin-chart temperature data, trace simulation for the original building design, Teanet simulation of original building design for the month of January 1959, Teanet simulation of Solar 2 for the month of January 1959, incremental solar cost assessment, and diffuse radiation incident on the monitor glass. (MHR)

  12. Gas recombination device design and cost study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    Under a contract with Argonne National Laboratory, VARTA Batterie AG. conducted a design and cost study of hydrogen-oxygen recombination devices (HORD) for use with utility load-leveling lead-acid cells. Design specifications for the devices, through extensive calculation of the heat-flow conditions of the unit, were developed. Catalyst and condenser surface areas were specified. The exact dimensions can, however, be adjusted to the cell dimension and the space available above the cell. Design specifications were also developed for additional components required to ensure proper function of the recombination device, including metal hydride compound decomposer, aerosol retainer, and gas storage component. Costs for HORD were estimated to range from $4 to $10/kWh cell capacity for the production of a large number of units (greater than or equal to 10,000 units). The cost is a function of cell size and positive grid design. 21 figures, 2 tables.

  13. Large pool LMFBR design. Final report. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Wett, J. F.; Churchill, J. R.

    1979-03-01

    The design effort reported is an extension on past design effort and continuous concentration on those parts of the nuclear island unique to a commercial size pool type LMFBR. In particular, the work covers the reactor vessel, deck, rotating plugs, upper and lower internals, internal plenum separator system, IHX, pumps, cold traps, intermediate system layout, containment/confinement system, plot plan, and residual heat removal systems. Preliminary thermal, hydraulic, stress, and system analyses are also presented.

  14. Fifth SIAM conference on geometric design 97: Final program and abstracts. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The meeting was divided into the following sessions: (1) CAD/CAM; (2) Curve/Surface Design; (3) Geometric Algorithms; (4) Multiresolution Methods; (5) Robotics; (6) Solid Modeling; and (7) Visualization. This report contains the abstracts of papers presented at the meeting. Proceding the conference there was a short course entitled ``Wavelets for Geometric Modeling and Computer Graphics``.

  15. Enhanced Internet firewall design using stateful filters final report

    Energy Technology Data Exchange (ETDEWEB)

    Hutchins, J.A. [Sandia National Labs., Livermore, CA (United States). Infrastructure and Networking Research Dept.; Simons, R.W. [Sandia National Labs., Albuquerque, NM (United States). Decision Support Systems Architectures

    1997-08-01

    The current state-of-the-art in firewall design provides a lot of security for company networks, but normally at the expense of performance and/or functionality. Sandia researched a new approach to firewall design which incorporates a highly stateful approach, allowing much more flexibility for protocol checking and manipulation while retaining performance. A prototype system was built and multiple protocol policy modules implemented to test the concept. The resulting system, though implemented on a low-power workstation, performed almost at the same performance as Sandia`s current firewall.

  16. Deepwater offshore windfarm. Design fabrication and installation study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This report discusses the plans and benefits of using the Beatrice oil field installation for the development of the offshore Beatrice windfarm in the Moray Firth. The development of an economic support structure for wind turbine generators to allow development of deepwater wind farms was investigated, and the screening of structural designs, and the analysis of fatigue, fabrication and installation considerations is described. Details are given of the recommendation for a further examination of two structural designs as options for the Beatrice windfarm development, the estimated costs, and the results of an environmental review.

  17. OTEC SKSS preliminary designs. Volume IV. Appendixes. Final report

    Energy Technology Data Exchange (ETDEWEB)

    ,

    1980-02-29

    This volume contains appendices to the Station Keeping Subsystem design study for the 40 MeW Modular Experiment OTEC platforms. Appendices presented include: detailed drag calculations; sample CALMS computer printouts for SPAR and BARGE static analyses; sample time domain computer printouts (Hydromechanics, Inc.) program; extreme value and fatigue load calculations; anchor design calculations; deployment calculations; bottom slope plots; time domain analysis report by Hydromechanics Inc.; detailed cost analysis; control systems study report by Sperry Systems Management; cost estimates for model basin tests; and hydrodynamic loading on the mooring cables. (WHK)

  18. ADVANCED TURBINE SYSTEM CONCEPTUAL DESIGN AND PRODUCT DEVELOPMENT - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Albrecht H. Mayer

    2000-07-15

    Asea Brown Boveri (ABB) has completed its technology based program. The results developed under Work Breakdown Structure (WBS) 8, concentrated on technology development and demonstration have been partially implemented in newer turbine designs. A significant improvement in heat rate and power output has been demonstrated. ABB will use the knowledge gained to further improve the efficiency of its Advanced Cycle System, which has been developed and introduced into the marked out side ABB's Advanced Turbine System (ATS) activities. The technology will lead to a power plant design that meets the ATS performance goals of over 60% plant efficiency, decreased electricity costs to consumers and lowest emissions.

  19. Design and synthesis of reactive separation systems. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Doherty, M.F.

    1992-12-31

    During the last decade there has been a rapid upturn in interest in reactive distillation. The chemical process industry recognizes the favorable economics of carrying out reaction simultaneously with distillation for certain classes of reacting systems, and many new processes have been built based on this technology. Interest is also increasing by academics and software vendors. Systematic design methods for reactive distillation systems have only recently begun to emerge. In this report we survey the available design techniques and point out the contributions made by our group at the University of Massachusetts.

  20. Conceptual design of advanced central receiver power system. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Tracey, T. R.

    1978-09-01

    The design of a 300 MWe tower focus power plant which uses molten salt heat transfer fluids and sensible heat storage is described in detail. The system consists of nine heliostat fields with 7711 heliostats in each. Four cavity receivers are located at the top of a 155-meter tower. Tasks include: (1) review and analysis of preliminary specification; (2) parametric analysis; (3) selection of preferred configuration; (4) commercial plant conceptual design; (5) assessment of commercial-sized advanced central power system; (6) development plan; (7) program plan; (8) reports and data; (9) program management; (10) safety analysis; and (11) material study and test program. (WHK)

  1. TIBER: Tokamak Ignition/Burn Experimental Research. Final design report

    Energy Technology Data Exchange (ETDEWEB)

    Henning, C.D.; Logan, B.G.; Barr, W.L.; Bulmer, R.H.; Doggett, J.N.; Johnson, B.M.; Lee, J.D.; Hoard, R.W.; Miller, J.R.; Slack, D.S.

    1985-11-01

    The Tokamak Ignition/Burn Experimental Research (TIBER) device is the smallest superconductivity tokamak designed to date. In the design plasma shaping is used to achieve a high plasma beta. Neutron shielding is minimized to achieve the desired small device size, but the superconducting magnets must be shielded sufficiently to reduce the neutron heat load and the gamma-ray dose to various components of the device. Specifications of the plasma-shaping coil, the shielding, coaling, requirements, and heating modes are given. 61 refs., 92 figs., 30 tabs. (WRF)

  2. Deepwater offshore windfarm. Design fabrication and installation study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This report discusses the plans and benefits of using the Beatrice oil field installation for the development of the offshore Beatrice windfarm in the Moray Firth. The development of an economic support structure for wind turbine generators to allow development of deepwater wind farms was investigated, and the screening of structural designs, and the analysis of fatigue, fabrication and installation considerations is described. Details are given of the recommendation for a further examination of two structural designs as options for the Beatrice windfarm development, the estimated costs, and the results of an environmental review.

  3. AGC-1 Experiment and Final Preliminary Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Robert L. Bratton; Tim Burchell

    2006-08-01

    This report details the experimental plan and design as of the preliminary design review for the Advanced Test Reactor Graphite Creep-1 graphite compressive creep capsule. The capsule will contain five graphite grades that will be irradiated in the Advanced Test Reactor at the Idaho National Laboratory to determine the irradiation induced creep constants. Seven other grades of graphite will be irradiated to determine irradiated physical properties. The capsule will have an irradiation temperature of 900 C and a peak irradiation dose of 5.8 x 10{sup 21} n/cm{sup 2} [E > 0.1 MeV], or 4.2 displacements per atom.

  4. Baseload Nitrate Salt Central Receiver Power Plant Design Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Tilley, Drake [Abengoa Solar LLC, Lakewood, CO (United States); Kelly, Bruce [Abengoa Solar LLC, Lakewood, CO (United States); Burkholder, Frank [Abengoa Solar LLC, Lakewood, CO (United States)

    2014-12-12

    The objectives of the work were to demonstrate that a 100 MWe central receiver plant, using nitrate salt as the receiver coolant, thermal storage medium, and heat transport fluid in the steam generator, can 1) operate, at full load, for 6,400 hours each year using only solar energy, and 2) satisfy the DOE levelized energy cost goal of $0.09/kWhe (real 2009 $). To achieve these objectives the work incorporated a large range of tasks relating to many different aspects of a molten salt tower plant. The first Phase of the project focused on developing a baseline design for a Molten Salt Tower and validating areas for improvement. Tasks included a market study, receiver design, heat exchanger design, preliminary heliostat design, solar field optimization, baseline system design including PFDs and P&IDs and detailed cost estimate. The baseline plant met the initial goal of less than $0.14/kWhe, and reinforced the need to reduce costs in several key areas to reach the overall $0.09/kWhe goal. The major improvements identified from Phase I were: 1) higher temperature salt to improve cycle efficiency and reduce storage requirements, 2) an improved receiver coating to increase the efficiency of the receiver, 3) a large receiver design to maximize storage and meet the baseload hours objective, and 4) lower cost heliostat field. The second Phase of the project looked at advancing the baseline tower with the identified improvements and included key prototypes. To validate increasing the standard solar salt temperature to 600 °C a dynamic test was conducted at Sandia. The results ultimately proved the hypothesis incorrect and showed high oxide production and corrosion rates. The results lead to further testing of systems to mitigate the oxide production to be able to increase the salt temperature for a commercial plant. Foster Wheeler worked on the receiver design in both Phase I and Phase II looking at both design and lowering costs utilizing commercial fossil boiler

  5. Advanced wind turbine design studies: Advanced conceptual study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, P; Sherwin, R [Atlantic Orient Corp., Norwich, VT (United States)

    1994-08-01

    In conjunction with the US Department of Energy and the National Renewable Energy Laboratory`s Advanced Wind Turbine Program, the Atlantic Orient Corporation developed preliminary designs for the next generation of wind turbines. These 50 kW and 350 kW turbines are based upon the concept of simplicity. By adhering to a design philosophy that emphasizes simplicity, we project that these turbines will produce energy at extremely competitive rates which will unlock the potential of wind energy domestically and internationally. The program consisted of three distinct phases. First, we evaluated the operational history of the Enertech 44 series wind turbines. As a result of this evaluation, we developed, in the second phase, a preliminary design for a new 50 kW turbine for the near-term market. In the third phase, we took a clean-sheet-of-paper approach to designing a 350 kW turbine focused on the mid-1990s utility market that incorporated past experience and advanced technology.

  6. Final design of the generic upper port plug structure for ITER diagnostic systems

    NARCIS (Netherlands)

    Pak, S.; Feder, R.; Giacomin, T.; Guirao, J.; Iglesias, S.; Josseaume, F.; Kalish, M.; Loesser, D.; Maquet, P.; Ronden, D.; Ordieres, J.; Panizo, M.; Pitcher, S.; M. Portalès,; Proust, M.; Serikov, A.; Suarez, A.; Tanchuk, V.; Udintsev, V.; Vacas, C.; Walsh, M.; Zhai, Y.

    2016-01-01

    The generic upper port plug (GUPP) structure in ITER is a 6 m long metal box which deploys diagnostic components into the vacuum vessel. This structure is commonly used for all the diagnostic upper ports. The final design of the GUPP structure, which has successfully passed the final design review i

  7. Photovoltaic subsystem optimization and design tradeoff study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Stolte, W.J.

    1982-03-01

    Tradeoffs and subsystem choices are examined in photovoltaic array subfield design, power-conditioning sizing and selection, roof- and ground-mounted structure installation, energy loss, operating voltage, power conditioning cost, and subfield size. Line- and self-commutated power conditioning options are analyzed to determine the most cost-effective technology in the megawatt power range. Methods for reducing field installation of flat panels and roof mounting of intermediate load centers are discussed, including the cost of retrofit installations.

  8. Final Design of the SLAC P2 Marx Klystron Modulator

    Energy Technology Data Exchange (ETDEWEB)

    Kemp, M.A.; Benwell, A.; Burkhart, C.; Larsen, R.; MacNair, D.; Nguyen, M.; Olsen, J.; /SLAC

    2011-11-08

    The SLAC P2 Marx has been under development for two years, and follows on the P1 Marx as an alternative to the baseline klystron modulator for the International Linear Collider. The P2 Marx utilizes a redundant architecture, air-insulation, a control system with abundant diagnostic access, and a novel nested droop correction scheme. This paper is an overview of the design of this modulator. There are several points of emphasis for the P2 Marx design. First, the modulator must be compatible with the ILC two-tunnel design. In this scheme, the modulator and klystron are located within a service tunnel with limited access and available footprint for a modulator. Access to the modulator is only practical from one side. Second, the modulator must have high availability. Robust components are not sufficient alone to achieve availability much higher than 99%. Therefore, redundant architectures are necessary. Third, the modulator must be relatively low cost. Because of the large number of stations in the ILC, the investment needed for the modulator components is significant. High-volume construction techniques which take advantage of an economy of scale must be utilized. Fourth, the modulator must be simple and efficient to maintain. If a modulator does become inoperable, the MTTR must be small. Fifth, even though the present application for the modulator is for the ILC, future accelerators can also take advantage of this development effort. The hardware, software, and concepts developed in this project should be designed such that further development time necessary for other applications is minimal.

  9. ITER neutral beam system US conceptual design. Final vesion

    Energy Technology Data Exchange (ETDEWEB)

    Purgalis, P.

    1990-09-01

    In this document we present the US conceptual design of a neutral beam system for International Thermonuclear Experimental Reactor (ITER). The design incorporates a barium surface conversion D{sup {minus}} source feeding a linear array of accelerator channels. The system uses a dc accelerator with electrostatic quadrupoles for strong focusing. A high voltage power supply that is integrated with the accelerator is presented as an attractive option. A gas neutralizer is used and residual ions exiting the neutralizer are deflected to water-cooled dumps. Cryopanels are located at the accelerator exit to pump excess gas from the source and the neutralizer, and in the ion dump cavity to pump re-neutralized ions and neutralizer gas. All the above components are packaged in compact identical, independent modules which can be removed for remote maintenance. The neutral beam system delivers 75 MW of DO at 1.3 MeV, into three ports with a total of 9 modules arranged in stacks of three modules per port . To increase reliability each module is designed to deliver up to 10 MW; this allows eight modules operating at partial capacity to deliver the required power in the event one module is out of service, and provides 20% excess capacity to improve availability. Radiation protection is provided by shielding and by locating critical components in the source and accelerator 46.5 m from the torus centerline. Neutron shielding in the drift duct and neutralizer provides the added feature of limiting conductance and thus reducing gas flow to and from the torus.

  10. High quality Danish design with intelligent LED light. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, Paul Michael; Dam-Hansen, C.; Thestrup, B.; Pedersen, Henrik (Technical Univ. of Denmark, DTU Fotonik, Roskilde (Denmark)); Olsen, Jesper (JesperOlsen ApS, Frederiksberg (Denmark)); Falleboe, H.; Andersen, Jakob (MORFOSO, Copenhagen (Denmark))

    2010-02-15

    Based on the results achieved in a previous project, which enabled a number of designers to be trained in the potential of LED lighting technology, this project developed intelligent LED fixtures for work purposes and for private homes. The two types of fixtures both meet the original project objective of good colour rendition with Ra indices above 90 and colour temperatures variable within the interval 3,300 to 4,400 K. Furthermore, with luminous efficacies of 60 lumen/W, both fixtures have energy efficiencies exceeding that of an average energy-friendly light source. (ln)

  11. Buildings energy management program workshop design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-12-01

    This document describes activities undertaken by Honeywell's Energy Resources Center for design and development of the format, content, and materials that were used in conducting 129 one-day energy management workshops for specific commercial business audiences. The Building Energy Management Workshop Program was part of a National Workshop Program that was intended to increase awareness of energy-related issues and to encourage energy-conservation actions on the part of commercial and industrial sectors. The total effort included executive conferences for chief executive officers and other senior management personnel; industrial energy-conservation workshops directed at plant management and engineering personnel; vanpooling workshops designed to inform and encourage business in implementing a vanpooling program for employees; and the building energy-management workshops specifically developed for managers, owners, and operators of office and retail facilities, restaurants, and supermarkets. The total program spanned nearly two years and reached approximately 2,500 participants from all parts of the U.S. A detailed followup evaluation is still being conducted to determine the impact of this program in terms of conservation action undertaken by workshop participants.

  12. VHTR engineering design study: intermediate heat exchanger program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1976-11-01

    The work reported is the result of a follow-on program to earlier Very High Temperature Reactor (VHTR) studies. The primary use of the VHTR is to provide heat for various industrial processes, such as hydrocarbon reforming and coal gasification. For many processes the use of an intermediate heat transfer barrier between the reactor coolant and the process is desirable; for some processes it is mandatory. Various intermediate heat exchanger (IHX) concepts for the VHTR were investigated with respect to safety, cost, and engineering design considerations. The reference processes chosen were steam-hydrocarbon reforming, with emphasis on the chemical heat pipe, and steam gasification of coal. The study investigates the critically important area of heat transfer between the reactor coolant, helium, and the various chemical processes.

  13. Optimized ground coupled heat pump design: Phase 1, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Andrews, J.W.; Catan, M.; Le Doux, P.; Metz, P.D.; Saunders, J.H.

    1985-10-01

    This report describes the first phase of a project to design a water-to-air heat pump optimized for ground coupling applications. The project is being conducted jointly by Brookhaven National Laboratory (BNL), Oak Ridge National Laboratory (ORNL), and an industrial partner to be selected via a competitive procurement. In the completion of Phase I, three major tasks were completed. First, based on experimental work performed at BNL, water-refrigerant heat exchanger models were developed for incorporation into the ORNL heat pump optimization program. Next, a procedure was developed to generate correlations between heat pump entering fluid temperature and load. The correlations, called ''Source Temperature/Load Maps'', will tell the optimization program how many hours/season the heat pump will operate with any pair of values for these quantities. This report discusses these first two tasks within Phase I.

  14. District cooling engineering & design program. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    1994-03-01

    Phoenix, Arizona is located in the Sonoran desert. Daytime temperatures typically rise to over 100 F during the three summer months. Average and peak temperatures have tended to rise over recent decades. This is generally attributed to what is known as the heat island effect, due to an increase in heat absorbing concrete and a decrease in irrigated farmland in the area. Phoenix is the eighth largest city in the US with a population of just over one million (1,000,000). The metropolitan area is one of the fastest growing in the nation. Over the last ten years its population has increased by over 40%. It is not an exaggeration to say the general availability of refrigerated air conditioning, both for buildings and automobiles has been an important factor enabling growth. The cost of operating public buildings has risen significantly in the last decade. In fiscal year 92/93 the City of Phoenix had energy expenses of over thirty four million dollars ($34,000,000). Because the City was planning a major new construction project, a new high-rise City Hall, it was decided to study and then optimize the design and selection of building systems to minimize long term owning and operating costs. The City Hall was to be constructed in downtown Phoenix. Phoenix presently owns other buildings in the area. A number of large cooling systems serving groups of buildings are currently operating in the Phoenix area. The City requested that the design consultants analyze the available options and present recommendations to the City`s engineering staff.

  15. Canister Cleaning System Final Design Report Project A-2A

    Energy Technology Data Exchange (ETDEWEB)

    FARWICK, C.C.

    2000-06-15

    Approximately 2,300 metric tons Spent Nuclear Fuel (SNF) are currently stored within two water filled pools, the 105 K East (KE) fuel storage basin and the 105 K West (KW) fuel storage basin, at the U.S. Department of Energy, Richland Operations Office (RL). The SNF Project is responsible for operation of the K Basins and for the materials within them. A subproject to the SNF Project is the Debris Removal Subproject, which is responsible for removal of empty canisters and lids from the basins. The Canister Cleaning System (CCS) is part of the Debris Removal Project. The CCS will be installed in the KW Basin and operated during the fuel removal activity. The KW Basin has approximately 3600 canisters that require removal from the basin. The CCS is being designed to ''clean'' empty fuel canisters and lids and package them for disposal to the Environmental Restoration Disposal Facility complex. The system will interface with the KW Basin and be located in the Dummy Elevator Pit.

  16. Design of slurry reactor for indirect liquefaction applications. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Prakash, A.; Bendale, P.G.

    1991-12-31

    The objective of this project is to design and model a conceptual slurry reactor for two indirect liquefaction applications; (1) production of methanol and (2) production of hydrocarbon fuels via Fischer-Tropsch route. A slurry reactor is defined here as a three-phase bubble column reactor using a fine catalyst particle suspension in a high molecular weight liquid. The feed gas is introduced through spargers. It then bubbles through the column providing the agitation necessary for catalyst suspension and mass transfer. The reactor models for the two processes have been formulated using computer simulation. Process data, kinetic and thermodynamic data, heat and mass transfer data and hydrodynamic data have been used in the mathematical models to describe the slurry reactor for each of the two processes. Available data from process development units and demonstration units were used to test and validate the models. Commercial size slurry reactors for methanol and Fischer-Tropsch synthesis were sized using reactor models developed in this report.

  17. Blade System Design Study. Part II, final project report (GEC).

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, Dayton A. (DNV Global Energy Concepts Inc., Seattle, WA)

    2009-05-01

    As part of the U.S. Department of Energy's Low Wind Speed Turbine program, Global Energy Concepts LLC (GEC)1 has studied alternative composite materials for wind turbine blades in the multi-megawatt size range. This work in one of the Blade System Design Studies (BSDS) funded through Sandia National Laboratories. The BSDS program was conducted in two phases. In the Part I BSDS, GEC assessed candidate innovations in composite materials, manufacturing processes, and structural configurations. GEC also made recommendations for testing composite coupons, details, assemblies, and blade substructures to be carried out in the Part II study (BSDS-II). The BSDS-II contract period began in May 2003, and testing was initiated in June 2004. The current report summarizes the results from the BSDS-II test program. Composite materials evaluated include carbon fiber in both pre-impregnated and vacuum-assisted resin transfer molding (VARTM) forms. Initial thin-coupon static testing included a wide range of parameters, including variation in manufacturer, fiber tow size, fabric architecture, and resin type. A smaller set of these materials and process types was also evaluated in thin-coupon fatigue testing, and in ply-drop and ply-transition panels. The majority of materials used epoxy resin, with vinyl ester (VE) resin also used for selected cases. Late in the project, testing of unidirectional fiberglass was added to provide an updated baseline against which to evaluate the carbon material performance. Numerous unidirectional carbon fabrics were considered for evaluation with VARTM infusion. All but one fabric style considered suffered either from poor infusibility or waviness of fibers combined with poor compaction. The exception was a triaxial carbon-fiberglass fabric produced by SAERTEX. This fabric became the primary choice for infused articles throughout the test program. The generally positive results obtained in this program for the SAERTEX material have led to its

  18. Final Report, "Molecular Design of Hydrocarbon Oxidation Catalytic Processes"

    Energy Technology Data Exchange (ETDEWEB)

    Professor Francisco Zaera

    2007-08-09

    production of small amounts of ethylene and water, most likely via the concerted decomposition or disproportionation of the adsorbed molecular species. The bulk of the 2-iodoethanol decomposes at about 150 K via an initial carbon-iodine scission to form –O(H)CH2CH2– (~80%) and 2-hydroxyethyl (~20%) intermediates. Two competing reactions are involved with the subsequent conversion of the 2-hydroxyethyl species around 160 K, a reductive elimination with surface hydrogen to yield ethanol, and a β-H elimination to surface vinyl alcohol. The –O(H)CH2CH2–, on the other hand, dehydrogenates to a –OCH2CH2– oxametallacycle species about the same temperature. Both 2-hydroxyethyl and oxametallacycle species tautomerize to acetaldehyde, around 210 K and above 250 K, respectively, and some of that acetaldehyde desorbs while the rest decomposes to hydrogen and carbon monoxide. We contend that a better understanding of the surface chemistry of oxygen-containing surfaces can lead to better selectivities in catalysis. This is arguably the most important issue in the field of catalysis in the near future, and one that impacts several technologies of interest to DOE such as the manufacturing of speciality chemicals and the control and removal of pollutants. Additional work was performed on the characterization of the chemistry of methyl and methylene adsorbed species on oxygen-treated nickel surfaces. Complex chemistry was observed involving not only hydrogenation and dehydrogenation steps, but also C-C couplings and methylene insertions to produce heavier hydrocarbons, and oxygen insertion reactions that yield oxygenates. Finally, a dual titration technique employing xenon and a chemically sensitive probe was developed to identify minority catalytic sites on oxide surfaces. In the case of oxygen-treated Ni(110) single crystals, it was found that both hydrogen transfer with adsorbed water or ammonia and certain hydrocarbon hydrogenation reactions take place at the end of the

  19. 76 FR 74000 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2011-11-30

    ... Section, Air Planning Branch, Multimedia Planning and Permitting Division, U.S. Environmental Protection... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION... Ozone Standard AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is...

  20. 75 FR 2091 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-01-14

    ... quality design value. Shelby County, Tennessee was originally designated as a marginal nonattainment area... for Air Quality Planning Purposes; Arkansas; Redesignation of the Crittenden County, Arkansas Portion... Arkansas, through the Arkansas Department of Environmental Quality (ADEQ), submitted a request...

  1. Final turbine and test facility design report Alden/NREC fish friendly turbine

    Energy Technology Data Exchange (ETDEWEB)

    Cook, Thomas C. [Alden Research Lab., Holden, MA (United States); Cain, Stuart A. [Alden Research Lab., Holden, MA (United States); Fetfatsidis, Paul [Alden Research Lab., Holden, MA (United States); Hecker, George E. [Alden Research Lab., Holden, MA (United States); Stacy, Philip S. [Alden Research Lab., Holden, MA (United States)

    2000-09-01

    The final report provides an overview of the Alden/NREC Fish Friendly turbine design phase, turbine test plan, preliminary test results, costs, schedule, and a hypothetical application at a real world project.

  2. Passive solar commercial buildings: design assistance and demonstration program. Phase 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-01-26

    The final design of the Mount Airy Public Library is given. Incremental passive design costs are discussed. Performance and economic analyses are made and the results reported. The design process is thoroughly documented. Considerations discussed are: (1) building energy needs; (2) site energy potentials, (3) matching energy needs with site energy potentials, (4) design indicators for best strategies and concepts, (5) schematic design alternatives, (6) performance testing of the alternatives, (7) design selection, and (8) design development. Weather data and Duke Power electric rates are included. (LEW)

  3. Passive solar commercial buildings: design assistance and demonstration program. Phase 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-01-26

    The final design of the Mount Airy Public Library is given. Incremental passive design costs are discussed. Performance and economic analyses are made and the results reported. The design process is thoroughly documented. Considerations discussed are: (1) building energy needs; (2) site energy potentials, (3) matching energy needs with site energy potentials, (4) design indicators for best strategies and concepts, (5) schematic design alternatives, (6) performance testing of the alternatives, (7) design selection, and (8) design development. Weather data and Duke Power electric rates are included. (LEW)

  4. Mod-5A wind turbine generator program design report. Volume 3: Final design and system description, book 2

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3MW MOD-5A wind turbine generator is documented. The report is divided into four volumes: Volume 1 summarizes the entire MOD-5A program, Volume 2 discusses the conceptual and preliminary design phases, Volume 3 describes the final design of the MOD-5A, and Volume 4 contains the drawings and specifications developed for the final design. Volume 3, book 2 describes the performance and characteristics of the MOD-5A wind turbine generator in its final configuration. The subsystem for power generation, control, and instrumentation subsystems is described in detail. The manufacturing and construction plans, and the preparation of a potential site on Oahu, Hawaii, are documented. The quality assurance and safety plan, and analyses of failure modes and effects, and reliability, availability and maintainability are presented.

  5. The Cryogenic AntiCoincidence detector for ATHENA: the progress towards the final pixel design

    Science.gov (United States)

    Macculi, Claudio; Piro, Luigi; Cea, Donatella; Colasanti, Luca; Lotti, Simone; Natalucci, Lorenzo; Gatti, Flavio; Bagliani, Daniela; Biasotti, Michele; Corsini, Dario; Pizzigoni, Giulio; Torrioli, Guido; Barbera, Marco; Mineo, Teresa; Perinati, Emanuele

    2014-07-01

    related to one of the last sample produced (namely AC-S5), and steps to reach the final detector design will be discussed.

  6. 78 FR 1149 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2013-01-08

    ..., specific projects (including, among others, the Nellis Air Force Base F-35 beddown project), and emissions...). See Wall v. EPA, 265 F.3d 426, 439 (6th Cir. 2001) upholding this interpretation. With respect to the... publication of this final rule in the Federal Register (see 40 CFR 93.118(f)(2)) and must be used by...

  7. 75 FR 59090 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-09-27

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION... for the Carbon Monoxide Standard AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule... reinstatement of the existing vapor pressure limit in the State wintertime gasoline rule, if necessary, to...

  8. 75 FR 62026 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-10-07

    ... under subpart 1, based upon their 8-hour ambient air quality design values. Knox County (which is a part... are attained if the design value is 0.084 ppm or below. The data must be collected and quality-assured... for Air Quality Planning Purposes; Tennessee; Redesignation of the Knoxville 8-Hour...

  9. Puzzles in modern biology. I. Male sterility, failure reveals design [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Steven A. Frank

    2016-09-01

    Full Text Available Many human males produce dysfunctional sperm. Various plants frequently abort pollen. Hybrid matings often produce sterile males. Widespread male sterility is puzzling. Natural selection prunes reproductive failure. Puzzling failure implies something that we do not understand about how organisms are designed. Solving the puzzle reveals the hidden processes of design.

  10. Experimental and Theoretical Progress of Linear Collider Final Focus Design and ATF2 Facility

    CERN Document Server

    Seryi, Andrei; Zimmermann, Frank; Kubo, Kiyoshi; Kuroda, Shigeru; Okugi, Toshiyuki; Tauchi, Toshiaki; Terunuma, Nobuhiro; Urakawa, Junji; White, Glen; Woodley, Mark; Angal-Kalinin, Deepa

    2014-01-01

    In this brief overview we will reflect on the process of the design of the linear collider (LC) final focus (FF) optics, and will also describe the theoretical and experimental efforts on design and practical realisation of a prototype of the LC FF optics implemented in the ATF2 facility at KEK, Japan, presently being commissioned and operated.

  11. 76 FR 53853 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2011-08-30

    ... NAAQS. B. What is ozone and why do we regulate it? Ozone, a gas composed of three oxygen atoms, at the... proceed with designations. The actions addressed in today's proposed rulemaking relate only to...

  12. 75 FR 26685 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Science.gov (United States)

    2010-05-12

    ... subpart 1, based upon their 8-hour ambient air quality design values. Northern Kentucky (as part of the bi... Air Quality Planning Purposes; Kentucky; Redesignation of the Kentucky Portion of the Cincinnati... Energy and Environment Cabinet, Division for Air Quality (DAQ), submitted a request to redesignate...

  13. 76 FR 56701 - Approval and Promulgation of Implementation Plans and Designations of Areas for Air Quality...

    Science.gov (United States)

    2011-09-14

    ... Particulate Matter Standards AGENCY: Environmental Protection Agency (EPA). ACTION: Proposed rule. SUMMARY... any personal information provided, unless the comment includes information claimed to be Confidential... the technical support document (TSD) for this proposal. The three year annual design values both with...

  14. 77 FR 4822 - Western Hemisphere Travel Initiative: Designation of an Approved Native American Tribal Card...

    Science.gov (United States)

    2012-01-31

    ... Section 7209 of the Intelligence Reform and Terrorism Prevention Act of 2004 (IRTPA), Public Law 108-458... known as the Western Hemisphere Travel Initiative (WHTI) at U.S. land and sea ports of entry. See 73 FR... Caribbean Sea, except Cuba.'' This definition applies to 8 CFR 212.1 and 235.1. Upon the designation by...

  15. ERM 593 Applied Project_Guidance for Reviewing and Approving a Waste Stream Profile in the Waste Compliance and Tracking System_Final_05-05-15

    Energy Technology Data Exchange (ETDEWEB)

    Elicio, Andy U. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-05-05

    My ERM 593 applied project will provide guidance for the Los Alamos National Laboratory Waste Stream Profile reviewer (i.e. RCRA reviewer) in regards to Reviewing and Approving a Waste Stream Profile in the Waste Compliance and Tracking System. The Waste Compliance and Tracking system is called WCATS. WCATS is a web-based application that “supports the generation, characterization, processing and shipment of LANL radioactive, hazardous, and industrial waste.” The LANL generator must characterize their waste via electronically by filling out a waste stream profile (WSP) in WCATS. Once this process is completed, the designated waste management coordinator (WMC) will perform a review of the waste stream profile to ensure the generator has completed their waste stream characterization in accordance with applicable state, federal and LANL directives particularly P930-1, “LANL Waste Acceptance Criteria,” and the “Waste Compliance and Tracking System User's Manual, MAN-5004, R2,” as applicable. My guidance/applied project will describe the purpose, scope, acronyms, definitions, responsibilities, assumptions and guidance for the WSP reviewer as it pertains to each panel and subpanel of a waste stream profile.

  16. Mod-5A wind turbine generator program design report. Volume 3: Final design and system description, book 1

    Science.gov (United States)

    1984-01-01

    The design, development and analysis of the 7.3 MW MOD-5A wind turbine generator is documented. Volume 3, book 1 describes the performance and characteristics of the MOD-5A wind turbine generator in its final configuration. Each subsystem - the rotor, drivetrain, nacelle, tower and foundation is described in detail.

  17. Feed-pump hydraulic performance and design improvement, Phase I: research program design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Brown, W.H.; Gopalakrishnan, S.; Fehlau, R.; Thompson, W.E.; Wilson, D.G.

    1982-03-01

    As a result of prior EPRI-sponsored studies, it was concluded that a research program should be designed and implemented to provide an improved basis for the design, procurement, testing, and operation of large feed pumps with increased reliability and stability over the full range of operating conditions. This two-volume report contains a research plan which is based on a review of the present state of the art and which defines the necessary R and D program and estimates the benefits and costs of the program. The recommended research program consists of 30 interrelated tasks. It is designed to perform the needed research; to verify the results; to develop improved components; and to publish computer-aided design methods, pump specification guidelines, and a troubleshooting manual. Most of the technology proposed in the research plan is applicable to nuclear power plants as well as to fossil-fired plants. This volume contains appendixes on pump design, cavitation damage, performance testing, hydraulics, two-phase flow in pumps, flow stability, and rotor dynamics.

  18. Final safety evaluation report related to the certification of the System 80{sup +} design (Docket No. 52-002). Volume 2, Chapters 15--22 and appendices

    Energy Technology Data Exchange (ETDEWEB)

    1994-08-01

    This final safety evaluation report (FSER) documents the technical review of the System 80+ standard design by the US Nuclear Regulatory Commission (NRC) staff. The application for the system 80+ design was submitted by Combustion Engineering, Inc., now Asea Brown Boveri-Combustion Engineering (ABB-CE) as an application for design approval and subsequent design certification pursuant to 10 CFR {section} 52.45. System 80+ is a pressurized water reactor with a rated power of 3914 megawatts thermal (MWt) and a design power of 3992 MWt at which accidents are analyzed. Many features of the System 80+ are similar to those of ABB-CE`s System 80 design from which it evolved. Unique features of the System 80+ design include: a large spherical, steel containment; an in-containment refueling water storage tank; a reactor cavity flooding system, hydrogen ignitors and a safety depressurization system for severe accident mitigation; a combustion gas turbine for an alternate ac source; and an advanced digitally based control room. On the basis of its evaluation and independent analyses, the NRC staff concludes that ABB-CE`s application for design certification meets the requirements of Subpart B of 10 CFR Part 52 that are applicable and technically relevant to the System 80+ standard design. This document, Volume 2, contains Chapters 15 through 22 and Appendices A through E.

  19. Final safety evaluation report related to the certification of the System 80{sup +} design (Docket No. 52-002). Volume 1, Chapters 1--14

    Energy Technology Data Exchange (ETDEWEB)

    1994-08-01

    This final safety evaluation report (FSER) documents the technical review of the System 80+ standard design by the US Nuclear Regulatory Commission (NRC) staff. The application for the System 80+ design was submitted by Combustion Engineering, Inc., now Asea Brown Boveri-Combustion Engineering (ABB-CE) as an application for design approval and subsequent design certification pursuant to 10 CFR {section} 52.45. System 80+ is a pressurized water reactor with a rated power of 3914 megawatts thermal (MWt) and a design power of 3992 MWt at which accidents are analyzed. Many features of the System 80+ are similar to those of Abb-CE`s System 80 design from which it evolved. Unique features of the System 80+ design included: a large spherical, steel containment; an in-containment refueling water storage tank; a reactor cavity flooding system, hydrogen ignitors, and a safety depressurization system for severe accident mitigation; a combustion gas turbine for an alternate ac source; and an advanced digitally based control room. On the basis of its evaluation and independent analyses, the NRC staff concludes that ABB-CE`s application for design certification meets the requirements of Subpart B of 10 CFR Part 52 that are applicable and technically relevant to the System 80+ standard design. This document, Volume 1, contains Chapters 1 through 14 of this report.

  20. Design for an Analysis and Assessment of the Education Satellite Communications Demonstration: Final Report.

    Science.gov (United States)

    Practical Concepts, Inc., Washington, DC.

    A 3-month evaluation design effort developed a strategy and implementation plan for a policy level evaluation of the Educational Satellite Communications Demonstration (ESCD). The final report of the effort covers: (1) development of the evaluation strategy and plan; (2) data collection and analysis; (3) measurement of the impact of satellite TV…

  1. The effect size, study design, and development experience in commercially sponsored studies for new drug applications in approved drugs.

    Science.gov (United States)

    Fukunaga, Satoshi; Kusama, Makiko; Ono, Shunsuke

    2014-01-01

    Pharmaceutical companies incorporate different features into the trials for new drug applications (NDAs) to render them efficient, making use of their experience. The objective of this analysis was to examine the associations between outcome and features related to study design and clinical development experience in commercially sponsored clinical trials. We collected data of phase 2 and phase 3 trials of all the drugs that obtained approval for depression, schizophrenia, asthma, hypertension, and diabetes in Japan from 1970 to 2011. In total, 145 trials from 90 test drugs were eligible for our study. We calculated the effect size, the standard mean of differences between test drug and comparator therapeutic effects, as the objective variable for use in our analysis. A linear mixed effect model with nested and crossed random effects was used in the analysis including variety of therapeutic area, test drugs and clinical trials. The analysis showed that trial features including sample size, subjective endpoints and active comparator of the same mode of action were negatively associated with effect size. In addition, sponsors' domestic clinical development experience with similar drugs seemed to have a positive association, but prior development experience in foreign countries did not. The accumulation of skills and knowledge within sponsors, and accumulated experience in domestic professionals who implement clinical trials under study contracts with sponsors would be of great importance for yielding clear outcomes. This study provides additional evidence with respect to possible sizes and directions of the influence of study design features that must be considered when planning and implementing trials for new drug applications, and when retrospectively comparing outcomes from trials with different designs and environments.

  2. [Tampa Electric Company IGCC project]. Final public design report; Technical progress report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-07-01

    This final Public Design Report (PDR) provides completed design information about Tampa Electric Company`s Polk Power Station Unit No. 1, which will demonstrate in a commercial 250 MW unit the operating parameters and benefits of the integration of oxygen-blown, entrained-flow coal gasification with advanced combined cycle technology. Pending development of technically and commercially viable sorbent for the Hot Gas Cleanup System, the HGCU also is demonstrated. The report is organized under the following sections: design basis description; plant descriptions; plant systems; project costs and schedule; heat and material balances; general arrangement drawings; equipment list; and miscellaneous drawings.

  3. Design, construction, operation and evaluation of a prototype culm combustion boiler/heater unit. Final design of prototype unit

    Energy Technology Data Exchange (ETDEWEB)

    1980-10-01

    A final design of a prototype anthracite culm combustion boiler has been accomplished under Phase I of DOE Contract ET-78-C-01-3269. The prototype boiler has been designed to generate 20,000 pounds per hour of 150 psig saturated steam using low Btu (4000 Btu per pound) anthracite culm as a fuel. This boiler will be located at the industrial park of the Shamokin Area Industrial Corporation (SAIC). This program is directed at demonstrating the commercial viability of anthracite culm fueled FBC steam generation systems.

  4. Final design of the Switching Network Units for the JT-60SA Central Solenoid

    Energy Technology Data Exchange (ETDEWEB)

    Lampasi, Alessandro, E-mail: alessandro.lampasi@enea.it [National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Frascati (Italy); Coletti, Alberto; Novello, Luca [Fusion for Energy (F4E) Broader Fusion Development Department, Garching (Germany); Matsukawa, Makoto [Japan Atomic Energy Agency, Naka Fusion Institute, Mukouyama, Naka-si, Ibaraki-ken (Japan); Burini, Filippo; Taddia, Giuseppe; Tenconi, Sandro [OCEM Energy Technology, San Giorgio Di Piano (Italy)

    2014-04-15

    This paper describes the approved detailed design of the four Switching Network Units (SNUs) of the superconducting Central Solenoid of JT-60SA, the satellite tokamak that will be built in Naka, Japan, in the framework of the “Broader Approach” cooperation agreement between Europe and Japan. The SNUs can interrupt a current of 20 kA DC in less than 1 ms in order to produce a voltage of 5 kV. Such performance is obtained by inserting an electronic static circuit breaker in parallel to an electromechanical contactor and by matching and coordinating their operations. Any undesired transient overvoltage is limited by an advanced snubber circuit optimized for this application. The SNU resistance values can be adapted to the specific operation scenario. In particular, after successful plasma breakdown, the SNU resistance can be reduced by a making switch. The design choices of the main SNU elements are justified by showing and discussing the performed calculations and simulations. In most cases, the developed design is expected to exceed the performances required by the JT-60SA project.

  5. Advances in the Design of the SuperB Final Doublet

    Energy Technology Data Exchange (ETDEWEB)

    Paoloni, E.; Carmignani, N.; Pilo, F.; /Pisa U. /INFN, Pisa; Bettoni, S.; /CERN; Fabbricatore, P.; Farinon, S.; Musenich, R.; /INFN, Genoa; Bosi, F.; /INFN, Pisa; Biagini, M.E.; Raimondi, P.; /Frascati; Sullivan, M.; /SLAC

    2012-04-26

    SuperB is an asymmetric energy e{sup +}e{sup -} collider operating at the {Upsilon}(4S) peak with a design peak luminosity of 10{sup 36} Hz/cm{sup 2} to be built in Italy in the very near future. The design luminosity is almost a factor hundred higher than that of the present generation comparable facilities. To get the design luminosity a novel collision scheme, the so called 'large Piwinski angle with crab waist', has been designed. The scheme requires a short focus final doublet to reduce the vertical beta function down to {beta}*{sub y} = 0.2mm at the interaction point (IP). The final doublet will be composed by a set of permanent and superconducting (SC) quadrupoles. The SC quadrupole doublets QD0/QF1 will be placed as close to the IP as possible. This layout is critical because the space available for the doublets is very small. An advanced design of the quadrupole has been developed, based on the so-called helical coil concept. The paper discusses the design concept, the construction and the results of test of a model of the superconducting quadrupole based on NbTi technology. Future developments are also presented.

  6. Osiris and SOMBRERO inertial confinement fusion power plant designs. Volume 2, Designs, assessments, and comparisons, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Meier, W.R.; Bieri, R.L.; Monsler, M.J.

    1992-03-01

    The primary objective of the of the IFE Reactor Design Studies was to provide the Office of Fusion Energy with an evaluation of the potential of inertial fusion for electric power production. The term reactor studies is somewhat of a misnomer since these studies included the conceptual design and analysis of all aspects of the IFE power plants: the chambers, heat transport and power conversion systems, other balance of plant facilities, target systems (including the target production, injection, and tracking systems), and the two drivers. The scope of the IFE Reactor Design Studies was quite ambitious. The majority of our effort was spent on the conceptual design of two IFE electric power plants, one using an induction linac heavy ion beam (HIB) driver and the other using a Krypton Fluoride (KrF) laser driver. After the two point designs were developed, they were assessed in terms of their (1) environmental and safety aspects; (2) reliability, availability, and maintainability; (3) technical issues and technology development requirements; and (4) economics. Finally, we compared the design features and the results of the assessments for the two designs.

  7. Grid fault and design-basis for wind turbines - Final report

    DEFF Research Database (Denmark)

    Hansen, Anca Daniela; Cutululis, Nicolaos Antonio; Markou, Helen

    This is the final report of a Danish research project “Grid fault and design-basis for wind turbines”. The objective of this project has been to assess and analyze the consequences of the new grid connection requirements for the fatigue and ultimate structural loads of wind turbines....... The fulfillment of the grid connection requirements poses challenges for the design of both the electrical system and the mechanical structure of wind turbines. The development of wind turbine models and novel control strategies to fulfill the TSO’s requirements are of vital importance in this design. Dynamic...... expertise in different specialized design areas for wind turbines. In order to quantify the impact of the grid faults and grid requirements fulfillment on wind turbines structural loads and thus on their lifetime, a rainflow and a statistical analysis for fatigue and ultimate structural loads, respectively...

  8. Final Design and Performance Parameters of the Payloads PYREX, PHLUX and RESPECT on EXPERT

    Science.gov (United States)

    Lein, Sebastian; Steinbeck, Andreas; Preci, Arianit; Fertig, Markus; Herdrich, Georg; Röser, Hans-Peter; Auweter-Kurtz, Monika

    An overview of the IRS payload development for ESA's EXPERT mission is given. The final design and performance parameters of the payloads PYREX, PHLUX and RESPECT are described. PYREX is a sensor system measuring the thermal protection system (TPS) rear side temperature. PHLUX is a catalysis based experiment to determine the dissociation degree of the boundary layer. RESPECT applies optical emission spectroscopy to measure spectrally resolved the radiation onto a TPS surface.

  9. Design, construction and conditions of the application of unreinforced concrete final lining in conventionally driven tunnels

    Science.gov (United States)

    Faltýnek, Jan; Hořejší, Jiří; Mařík, Libor; Růžička, Pavel

    2017-09-01

    The way to an economic design in the final lining in conventionally driven tunnels lies in structural analysing based on the actually encountered geotechnical conditions. Regarding reinforced concrete structures, many standards and regulations applicable to designing and building structures and taking them over by the client before their commissioning and before the end of the warranty period respectively exist in the Czech Republic. If the local conditions allow it, it is possible to design the final lining as an unreinforced concrete structure. In such a case it is necessary to take the differences into consideration in the structural design and in the possibilities of the lining behaviour and to set criteria for taking over the lining allowing for its use. Setting too stringent criteria for cracking can lead to an increase in the contract price, either because of the necessity for reinforcing the lining or because of the fact that the contractor reduces the risk by incorporating the assumed cost of repairs into the total cost. The paper describes basic differences in the approach to reinforced concrete and unreinforced concrete linings, the possibilities of limiting formation of cracks by means of the concrete mix design, by selection of the technological procedure of the work and the method of curing after stripping. The text contains a comparison of criteria for assessing the surface of an unreinforced concrete lining with criteria in foreign regulations.

  10. Newman Unit 1 advanced solar repowering advanced conceptual design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1982-04-01

    The Newman Unit 1 solar repowering design is a water/steam central receiver concept supplying superheated steam. The work reported is to develop a refined baseline conceptual design that has potential for construction and operation by 1986, makes use of existing solar thermal technology, and provides the best economics for this application. Trade studies performed in the design effort are described, both for the conceptual design of the overall system and for the subsystem conceptual design. System-level functional requirements, design, operation, performance, cost, safety, environmental, institutional, and regulatory considerations are described. Subsystems described include the collector, receiver, fossil energy, electrical power generating, and master control subsystems, site and site facilities. The conceptual design, cost, and performance of each subsystem is discussed at length. A detailed economic analysis of the repowered unit is made to realistically assess the economics of the first repowered unit using present cost data for a limited production level for solar hardware. Finally, a development plan is given, including the design, procurement, construction, checkout, startup, performance validation, and commercial operation. (LEW)

  11. Design, fabrication, and certification of advanced modular PV power systems. Final technical progress report

    Energy Technology Data Exchange (ETDEWEB)

    Lambarski, T.; Minyard, G. [Solar Electric Specialties Co., Willits, CA (United States)

    1998-10-01

    Solar Electric Specialties Company (SES) has completed a two and a half year effort under the auspices of the US Department of Energy (DOE) PVMaT (Photovoltaic Manufacturing Technology) project. Under Phase 4A1 of the project for Product Driven System and Component Technology, the SES contract ``Design, Fabrication and Certification of Advanced Modular PV Power Systems`` had the goal to reduce installed system life cycle costs through development of certified (Underwriters Laboratories or other listing) and standardized prototype products for two of the product lines, MAPPS{trademark} (Modular Autonomous PV Power Supply) and Photogensets{trademark}. MAPPS are small DC systems consisting of Photovoltaic modules, batteries and a charge controller and producing up to about a thousand watt-hours per day. Photogensets are stand-alone AC systems incorporating a generator as backup for the PV in addition to a DC-AC inverter and battery charger. The program tasks for the two-year contract consisted of designing and fabricating prototypes of both a MAPPS and a Photogenset to meet agency listing requirements using modular concepts that would support development of families of products, submitting the prototypes for listing, and performing functionality testing at Sandia and NREL. Both prototypes were candidates for UL (Underwriters Laboratories) listing. The MAPPS was also a candidate for FM (Factory Mutual) approval for hazardous (incendiary gases) locations.

  12. Final design of the Korean AC/DC converters for the ITER coil power supply system

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Jong-Seok, E-mail: jsoh@nfri.re.kr [ITER Korea, National Fusion Research Institute, Daejeon 305-806 (Korea, Republic of); Choi, Jungwan; Suh, Jae-Hak; Choi, Jihyun [ITER Korea, National Fusion Research Institute, Daejeon 305-806 (Korea, Republic of); Lee, Lacksang; Kim, Changwoo; Park, Hyungjin; Jo, Seongman; Lee, Seungyun; Hwang, Kwangcheol; Liu, Hyoyol [Dawonsys Corp., Siheung 429-450 (Korea, Republic of); Hong, Ki-Don; Sim, Dong-Joon; Lee, Jang-Soo [Hyosung Corp., Gongdeok-Dong, Seoul 121-720 (Korea, Republic of); Lee, Eui-Jae; Kwon, Yang-Hae; Lee, Dae-Yeol; Ko, Ki-Won; Kim, Jong-Min [Mobiis Corp., Yangjae-dong, Seoul 137-888 (Korea, Republic of); Song, Inho [ITER Organization, Route de Vinon sur Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France); and others

    2015-10-15

    The final design of the ITER TF, CS, CC and VS AC/DC converters has been completed to implement ITER requirements following the detailed design and refinements of the preliminary design. The number of parallel thyristors and the rating of fuses are coordinated to keep those devices within the explosion limit even under most severe fault conditions. The impedance of the converter transformer has been optimized taking into account the energization inrush current, short circuit current, reactive power consumption and the available DC voltage. To ensure system integrity, AC/DC converters are mechanically divided into transformers, AC busbars, 6-pulse bridges, DC interconnecting busbars and DC reactors, and then all subsystems are decoupled by flexible links. To provide stable real time network communication down to the converters, a one GbE link is deployed between master controllers and local controllers. IEEE 1588 is implemented to the embedded controllers for precision time synchronization. This paper describes the detailed solutions implemented in the final design for the ITER AC/DC converters with R&D results of converter prototypes.

  13. Final design of a free-piston hydraulic advanced Stirling conversion system

    Science.gov (United States)

    Wallace, D. A.; Noble, J. E.; Emigh, S. G.; Ross, B. A.; Lehmann, G. A.

    1991-01-01

    Under the US Department of Energy's (DOEs) Solar Thermal Technology Program, Sandia National Laboratories is evaluating heat engines for solar distributed receiver systems. The final design is described of an engineering prototype advanced Stirling conversion system (ASCS) with a free-piston hydraulic engine output capable of delivering about 25 kW of electric power to a utility grid. The free-piston Stirling engine has the potential for a highly reliable engine with long life because it has only a few moving parts, has noncontacting bearings, and can be hermetically sealed. The ASCS is designed to deliver maximum power per year over a range of solar input with a design life of 30 years (60,000 h). The system includes a liquid Nak pool boiler heat transport system and a free-piston Stirling engine with high-pressure hydraulic output, coupled with a bent axis variable displacement hydraulic motor and a rotary induction generator.

  14. Final design of the generic upper port plug structure for ITER diagnostic systems

    Energy Technology Data Exchange (ETDEWEB)

    Pak, Sunil, E-mail: paksunil@nfri.re.kr [National Fusion Research Institute, Daejeon (Korea, Republic of); Feder, Russell [Princeton Plasma Physics Laboratory, Princeton, NJ (United States); Giacomin, Thibaud; Guirao, Julio; Iglesias, Silvia; Josseaume, Fabien [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Kalish, Michael; Loesser, Douglas [Princeton Plasma Physics Laboratory, Princeton, NJ (United States); Maquet, Philippe [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Ordieres, Javier; Panizo, Marcos [NATEC, Ingenieros, Gijón (Spain); Pitcher, Spencer; Portalès, Mickael [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Proust, Maxime [CEA, Cadarache, St. Paul-lez-Durance (France); Ronden, Dennis [FOM Institute DIFFER, Nieuwegein (Netherlands); Serikov, Arkady [Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen (Germany); Suarez, Alejandro [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); Tanchuk, Victor [NIIEFA, St.-Petersburg (Russian Federation); Udintsev, Victor; Vacas, Christian [ITER Organization, Route de Vinon sur Verdon, 13115 St Paul-lez-Durance (France); and others

    2016-01-15

    The generic upper port plug (GUPP) structure in ITER is a 6 m long metal box which deploys diagnostic components into the vacuum vessel. This structure is commonly used for all the diagnostic upper ports. The final design of the GUPP structure, which has successfully passed the final design review in 2013, is described here. The diagnostic port plug is cantilevered to the vacuum vessel with a heavy payload at the front, so called the diagnostic first wall (DFW) and the diagnostic shield module (DSM). Most of electromagnetic (EM) load (∼80%) occurs in DFW/DSM. Therefore, the mounting design to transfer the EM load from DFW/DSM to the GUPP structure is challenging, which should also comply with thermal expansion and tolerance for assembly and manufacturing. Another key design parameter to be considered is the gap between the port plug and the vacuum vessel port. The gap should be large enough to accommodate the remote handling of the heavy port plug (max. 25 t), the structural deflection due to external loads and machine assembly tolerance. At the same time, the gap should be minimized to stop the neutron streaming according to the ALARA (as low as reasonably achievable) principle. With these design constraints, the GUPP structure should also provide space for diagnostic integration as much as possible. This requirement has led to the single wall structure having the gun-drilled water channels inside the structure. Furthermore, intensive efforts have been made on the manufacturing study including material selection, manufacturing codes and French regulation related to nuclear equipment and safety. All these main design and manufacturing aspects are discussed in this paper, including requirements, interfaces, loads and structural assessment and maintenance.

  15. Final repository for spent nuclear fuel. Underground design Simpevarp, Layout D1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-04-15

    This report is a compilation of the results of the underground design work carried out in design phase D1 of the Repository Design Project within the Deep Repository Project for the Simpevarp site. Similar reports are also being produced for the Laxemar and Forsmark sites. The design phase coincides with the initial site investigation phase. The main purpose of phase D1 is to answer the question 'Can a final repository be accommodated within the designated site', but also to test the design methodology and provide feedback to the modelling project. Design was carried out in accordance with the methodology described in UDP (Underground Design Premises), SKB R-04-60, and was based on preliminary data from various disciplines in the site modelling project. The preliminary input data used were then cross-checked against data in the final Site Descriptive Model SDM v 1.2 and significant differences were integrated in the design work. The design results from each design topic were presented by the designer at presentation meetings for SKB's design management and the reviewers engaged by SKB for the specific topic. After the presentation meeting the designer wrote up the work reports for the topic in question. The work reports were then reviewed by SKB's review team. The results of the review were compiled in a statement that was submitted to the designer to be dealt with. In the statement the designer documented which comments were dealt with and how. This report is a compilation of the entire design phase D1 for Simpevarp. The 3D layout with coordinate lists for deposition holes and tunnels that was drawn to illustrate a possible layout was used in the Preliminary safety evaluation of the Simpevarp subarea and the hydro modelling of the Open Repository, both activities within the Deep Repository Project. According to current plans for the Swedish nuclear programme, the minimum required number of canister positions in the repository is estimated to be

  16. Final repository for spent nuclear fuel. Underground design Simpevarp, Layout D1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-04-15

    This report is a compilation of the results of the underground design work carried out in design phase D1 of the Repository Design Project within the Deep Repository Project for the Simpevarp site. Similar reports are also being produced for the Laxemar and Forsmark sites. The design phase coincides with the initial site investigation phase. The main purpose of phase D1 is to answer the question 'Can a final repository be accommodated within the designated site', but also to test the design methodology and provide feedback to the modelling project. Design was carried out in accordance with the methodology described in UDP (Underground Design Premises), SKB R-04-60, and was based on preliminary data from various disciplines in the site modelling project. The preliminary input data used were then cross-checked against data in the final Site Descriptive Model SDM v 1.2 and significant differences were integrated in the design work. The design results from each design topic were presented by the designer at presentation meetings for SKB's design management and the reviewers engaged by SKB for the specific topic. After the presentation meeting the designer wrote up the work reports for the topic in question. The work reports were then reviewed by SKB's review team. The results of the review were compiled in a statement that was submitted to the designer to be dealt with. In the statement the designer documented which comments were dealt with and how. This report is a compilation of the entire design phase D1 for Simpevarp. The 3D layout with coordinate lists for deposition holes and tunnels that was drawn to illustrate a possible layout was used in the Preliminary safety evaluation of the Simpevarp subarea and the hydro modelling of the Open Repository, both activities within the Deep Repository Project. According to current plans for the Swedish nuclear programme, the minimum required number of canister positions in the repository is estimated to be

  17. Design and implementation of fuzzy logic controllers. Thesis Final Report, 27 Jul. 1992 - 1 Jan. 1993

    Science.gov (United States)

    Abihana, Osama A.; Gonzalez, Oscar R.

    1993-01-01

    The main objectives of our research are to present a self-contained overview of fuzzy sets and fuzzy logic, develop a methodology for control system design using fuzzy logic controllers, and to design and implement a fuzzy logic controller for a real system. We first present the fundamental concepts of fuzzy sets and fuzzy logic. Fuzzy sets and basic fuzzy operations are defined. In addition, for control systems, it is important to understand the concepts of linguistic values, term sets, fuzzy rule base, inference methods, and defuzzification methods. Second, we introduce a four-step fuzzy logic control system design procedure. The design procedure is illustrated via four examples, showing the capabilities and robustness of fuzzy logic control systems. This is followed by a tuning procedure that we developed from our design experience. Third, we present two Lyapunov based techniques for stability analysis. Finally, we present our design and implementation of a fuzzy logic controller for a linear actuator to be used to control the direction of the Free Flight Rotorcraft Research Vehicle at LaRC.

  18. Design and fabrication of a prototype system for photovoltaic residences in the Southwest. ARTU final report

    Energy Technology Data Exchange (ETDEWEB)

    Sorenson, D.; McNamara, R.

    1982-10-01

    This is the final report for the Applied Research and Technology of Utah, Inc. (ARTU) Prototype System as established at the Southwest Residential Experiment Station (SW RES). The SW RES is operated by the New Mexico Solar Energy Institute (NMSEI) at Mexico State University in Las Cruces, New Mexico. It is intended that the SW RES be utilized to gather and disseminate data about the design, construction, and performance of photovoltaic electric power-generating systems for residential application when; connected to the utility grid. This report presents the ARTU solar residence design and details the design of the photovoltaic (PV) prototype System. Section 1 discusses the residence design and includes drawings of the residence and its energy audit. Section 2 describes the Prototype System from the aspects of structural, mechanical, and electrical design. Details are presented regarding the as-built conditions of the prototype, roof-loading considerations, the unique cooling system, a description of the PV modules, the module mounting method, the DC-to-AC inverter, and other power-conditioning equipment. Section 3 includes lessons learned during the project, costs incurred to complete the Prototype, and recommendations for different procedures for the next design. Section 4 presents a summary of the system operating and maintenance procedures.

  19. 78 FR 38359 - Approval of Record of Decision for Relocation of Cattle Point Road, San Juan Island National...

    Science.gov (United States)

    2013-06-26

    ... National Park Service Approval of Record of Decision for Relocation of Cattle Point Road, San Juan Island... approved a Record of Decision for the Final Environmental Impact Statement for the relocation of the Cattle... Historical Park will begin to implement design and initiate construction of the Cattle Point Road...

  20. Mechanical design of a pre-isolator for the CLIC final focusing magnets

    CERN Document Server

    Gaddi, A; Ramos, F; Siegrist, N

    2012-01-01

    Due to the very small vertical beam sizes, the final focusing elements at the future CLIC linear collider need to be stable against vibrations to below 0.15 nanometres at frequencies above about 4 Hz. One of the key elements in the strategy to achieve such a stable environment is a passive, heavy pre-isolator. In this report, the results from the dynamic finite element analyses of the proposed design for such a passive preisolator are summarized. Furthermore, the results from a low frequency, heavy mass passive vibration isolation test set-up used to validate the calculations are shown.

  1. Design and Manufacture of a Hybrid Final Focus Quadrupole Model for CLIC

    CERN Document Server

    Modena, Michele; Vorozhtsov, Alexey

    2012-01-01

    A tunable hybrid quadrupole magnet design has been proposed for the final focus in the Compact Linear Collider (CLIC) that is currently under study. The proposed design is a combination of an iron dominated electromagnetic quadrupole with a bore diameter of 8.25 mm with permanent magnet blocks placed between the poles made of soft magnetic CoFe alloy "Permendur". The possibility of using Sm2Co17 and Nd2Fe14B as material for the permanent magnet blocks has been investigated. It is shown that a very high field gradient of 530 T/m (Sm2Co17) and 590 T/m (Nd2Fe14B) can be achieved.

  2. Performance of the LHC Final Design, Full-Scale Superconducting Dipole Prototypes

    CERN Document Server

    Bottura, L; Siemko, A; Vlogaert, J; Wyss, C

    2001-01-01

    Within the LHC magnet program, a series of six, final design, full-scale superconducting dipole prototypes are presently being built in industry and tested at CERN. The main features of these magnets are: two-in-one structure, 56 mm aperture, six-block two layer coils wound from 15.1 mm wide graded NbTi cables, and all-polyimide insulation. This paper reviews the main test results of magnets tested to day at 4.2 K and 1.8 K. The results of the quench training, conductor performance, magnet protection, sensitivity to ramp rate and field quality are presented and discussed in terms of the design parameters and the aims of the full scale dipole prototype program.

  3. Designing the central knowledge base for the purposes of final works in architecture

    Directory of Open Access Journals (Sweden)

    Aleksić Ljiljana

    2014-01-01

    Full Text Available The solution for many issues related to the selection of construction products, currently present on the market, could be a Central knowledge base, consisting of verified and reliable data of construction products. Beside previous participants: investor, architect and contractor, that were involved in the processes of design and construction, herein is equally introduced manufacturer construction materials and products. The Central knowledge base consists of: a catalog sheets of the graphics base, alphanumeric base and base with textual data, and represents a flexible system that is subject to amendments. It is built to support architects during processes design and construction, as well as for education of students attending subject Final works at the Faculty of Civil Engineering in Subotica.

  4. Design, construction and testing of a DC bioeffects test enclosure for small animals. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Frazier, M J; Preache, M M

    1980-11-01

    This final report describes both the engineering development of a DC bioeffects test enclosure for small laboratory animals, and the biological protocol for the use of such enclosures in the testing of animals to determine possible biological effects of the environment associated with HVDC transmission lines. The test enclosure which has been designed is a modular unit, which will house up to eight rat-sized animals in individual compartments. Multiple test enclosures can be used to test larger numbers of animals. A prototype test enclosure has been fabricated and tested to characterize its electrical performance characteristics. The test enclosure provides a simulation of the dominant environment associated with HVDC transmission lines; namely, a static electric field and an ion current density. A biological experimental design has been developed for assessing the effects of the dominant components of the HVDC transmission line environment.

  5. Design finalization and material qualification towards procurement of the ITER vacuum vessel

    Energy Technology Data Exchange (ETDEWEB)

    Ioki, K., E-mail: Kimihiro.Ioki@iter.org [ITER Organization, CS 90 046, 13067 St. Paul-lez-Durance CEDEX (France); Barabash, V.; Bachmann, C.; Chappuis, P.; Choi, C.H.; Cordier, J-J.; Giraud, B.; Gribov, Y. [ITER Organization, CS 90 046, 13067 St. Paul-lez-Durance CEDEX (France); Heitzenroeder, Ph. [PPPL MS41, Princeton University, PO Box 451, Princeton, NJ 08543 (United States); Her, N.; Johnson, G. [ITER Organization, CS 90 046, 13067 St. Paul-lez-Durance CEDEX (France); Jones, L. [F4E, c/Josep Pla, n.2, Torres Diagonal Litoral, Edificio B3, E-08019, Barcelona (Spain); Jun, C. [ITER Organization, CS 90 046, 13067 St. Paul-lez-Durance CEDEX (France); Kim, B.C. [NFRI, 52 Yeoeundong Yuseonggu, Daejeon 305-333 (Korea, Republic of); Kuzmin, E. [NTC ' Sintez' , Efremov Inst., 189631 Metallostroy, St. Petersburg (Russian Federation); Loesser, D. [PPPL MS41, Princeton University, PO Box 451, Princeton, NJ 08543 (United States); Martin, A.; Merola, M. [ITER Organization, CS 90 046, 13067 St. Paul-lez-Durance CEDEX (France); Pathak, H. [IPR, Near Indira Bridge, Bhat, Gandhinagar 382 428 (India); Readman, P. [ITER Organization, CS 90 046, 13067 St. Paul-lez-Durance CEDEX (France)

    2011-10-01

    Procurement arrangements for ITER key components including the vacuum vessel (VV) have been signed and the ITER activities are now fully devoted towards construction. Final design reviews have been carried out for the main vessel and ports. One of the design review topics is the selection of materials, material procurement, and assessment of material performance during operation. The width of the inner shell splice plates was increased from 120 mm to 160 mm to minimize risk during the assembly of the Thermal shields and the VV. Instead of facet shaping, 3D shaping was introduced for the outboard inner shell. The material qualification procedures have been started for VV structural materials such as 316L(N) IG for licensing as a nuclear pressure equipment component. In accordance with the regulatory requirements and quality requirements for operation, common material specifications have been prepared in collaboration with the domestic agencies.

  6. Next Generation Nuclear Plant (NGNP) Prismatic HTGR Conceptual Design Project - Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Saurwein, John

    2011-07-15

    This report is the Final Technical Report for the Next Generation Nuclear Plant (NGNP) Prismatic HTGR Conceptual Design Project conducted by a team led by General Atomics under DOE Award DE-NE0000245. The primary overall objective of the project was to develop and document a conceptual design for the Steam Cycle Modular Helium Reactor (SC-MHR), which is the reactor concept proposed by General Atomics for the NGNP Demonstration Plant. The report summarizes the project activities over the entire funding period, compares the accomplishments with the goals and objectives of the project, and discusses the benefits of the work. The report provides complete listings of the products developed under the award and the key documents delivered to the DOE.

  7. Toward a final design for the Birmingham boron neutron capture therapy neutron beam.

    Science.gov (United States)

    Allen, D A; Beynon, T D; Green, S; James, N D

    1999-01-01

    This paper is concerned with the proposed Birmingham accelerator-based epithermal neutron beam for boron neutron capture therapy (BNCT). Details of the final moderator design, such as beam delimiter, shield, and beam exit surface shape are considered. Monte Carlo radiation transport simulations with a head and body phantom have shown that a simple flat moderator beam exit surface is preferable to the previously envisioned spherical design. Dose rates to individual body organs during treatment have been calculated using a standard MIRD phantom. We have shown that a simple polyethylene shield, doped with natural lithium, is sufficient to provide adequate protection to the rest of the body during head irradiations. The effect upon the head phantom dose distributions of the use of such a shield to delimit the therapy beam has been evaluated.

  8. Design and test of the final ALICE SDD CARLOS end ladder board

    CERN Document Server

    Antinori, S; Falchieri, D; Gabrielli, A; Gandolfi, E; Masetti, M; Tosellob, F

    2007-01-01

    The paper presents the design and test of the final prototype of the CARLOS (Compression And Run Length Encoding Subsystem) end ladder board that is going to be used in the ALICE experiment at CERN. This board is able to compress data coming from one Silicon Drift Detector (SDD) front-end electronics and to send them towards the data concentrator card CARLOSrx in counting room via a 800 Mb/s optical link. The board design faces several constraints, mainly size (54x49 mm) and radiation tolerance: for this reason the board contains several CERN developed ASICs. A test setup has been realized for selecting the good devices among the 500 cards already produced.

  9. Final cross section design of the stripline kicker for the CLIC damping rings

    CERN Document Server

    Belver-Aguilar, C; Barnes, M J; Toral, F

    2012-01-01

    The CLIC design relies on the presence of Pre-Damping Rings (PDR) and Damping Rings (DR) to achieve, through synchrotron radiation, the very low emittance needed to fulfill the luminosity requirements. Kicker systems are required to inject and extract the beam from the Pre-Damping and Damping Rings. In order to achieve both low beam coupling impedance and reasonable broadband impedance matching to the electrical circuit, striplines have been chosen for the kicker elements. In this paper the final design for the DR kicker is presented, including an optimization of the geometric parameters to achieve the requirements for both characteristic impedance and field homogeneity. In addition, a sensitivity analysis of characteristic impedance and field homogeneity to geometric parameters is reported.

  10. Final Design And Manufacturing of the PEP II High Energy Ring Arc Bellows Module

    Energy Technology Data Exchange (ETDEWEB)

    Kurita, Nadine R.; Kulikov, Artem; /SLAC; Corlett, John; /LBL, Berkeley

    2011-09-01

    A novel RF shield bellows module developed at SLAC has been successfully manufactured and installed in the PEP-II High Energy Ring (HER). Tests indicate that the module meets its performance and operational requirements. The primary function of the bellows module is to allow for thermal expansion of the chambers and for lateral, longitudinal and angular offsets due to tolerances and alignment, while providing RF continuity between adjoining chambers. An update on the Arc bellows module for the PEP-II High Energy Ring is presented. Final design, manufacturing issues, material and coating selection, and tribological and RF testing are discussed. Performance and operational requirements are also reviewed. The RF shield design has been proven during assembly to allow for large manufacturing tolerances without reducing the mechanical spring force below required values. In addition, the RF shield maintains electrical contact even with large misalignments across the module.

  11. Design optimization of the International Linear Collider Final Focus System with a long L*

    CERN Document Server

    Plassard, Fabien

    This Master's Thesis work has been done in the Aerospace Engineering master's programme framework and carried out at the European Organization for Nuclear Research (CERN). It was conducted under the 500 GeV e-e+ International Linear Collider (ILC) study and focused on the design and performance optimization of the Final Focus System (FFS). The purpose of the final focus system of the future linear colliders (ILC and CLIC) is to demagnify the beam to the required transverse size at the interaction point (IP). The FFS is designed for a flat-beam in a compact way based on a local chromaticity correction which corrects both horizontal and vertical chromaticities simultaneously. An alternative FFS configuration based on the traditional scheme with two dedicated chromatic correction sections for horizontal and vertical chromaticities and a long L * option has been developed. A longer free space between the last quadrupole and the IP allows to place the last quadrupole on a stable ground, with fewer engineering ...

  12. Test and approval center for fuel cell and hydrogen technologies: Phase I. Initiation. Final report; Test- og godkendelsescenter for braendselscelle- og brintteknologier. Fase 1. Opstart. Slutrapport

    Energy Technology Data Exchange (ETDEWEB)

    Hagen, A. [Technical Univ. of Denmark. DTU Energy Conversion, DTU Risoe Campus, Roskilde (Denmark)

    2012-09-15

    The aim of the present project was to initialize a Test and Approval Center for Fuel Cell and Hydrogen Technologies at the sites of the project partners Risoe DTU (Fuel Cells and Solid State Chemistry Division), and DGC (work package 1). The project furthermore included start-up of first activities with focus on the development of accelerated life-time tests of fuel cell systems, preparations for standardization of these methods, and advising in relation to certification and approval of fuel cell systems (work package 2). The main achievements of the project were: Work package 1: 1) A large national and international network was established comprising of important commercial players, research institutions, and other test centers; 2) The test center is known in large part of the international Fuel Cell and Hydrogen community due to substantial efforts in 'marketing'; 3) New national and international projects have been successfully applied for, with significant roles of the test center, which secure the further establishment and development of the center. Work package 2: 1) Testing equipment was installed and commissioned at DTU (Risoe Campus); 2) A comprehensive survey among international players regarding activities on accelerated SOFC testing was carried out; 3) A test procedure for 'compressed' testing of SOFC in relation to {mu} CHP application was developed and used for one-cell stack and 50-cell-stack testing; 4) Guidelines for Danish authority handling were formulated. (Author)

  13. Is the large simple trial design used for comparative, post-approval safety research? A review of a clinical trials registry and the published literature.

    Science.gov (United States)

    Reynolds, Robert F; Lem, Joanna A; Gatto, Nicolle M; Eng, Sybil M

    2011-10-01

    Post-approval, observational drug safety studies face well known difficulties in controlling for confounding, particularly confounding by indication for drug use. A study design that addresses confounding by indication is the large simple trial (LST). LSTs are characterized by large sample sizes, often in the thousands; broad entry criteria consistent with the approved medication label; randomization based on equipoise, i.e. neither physician nor patient believes that one treatment option is superior; minimal, streamlined data collection requirements; objectively-measured endpoints (e.g. death, hospitalization); and follow-up that minimizes interventions or interference with normal clinical practice. In theory then, the LST is a preferred study design for drug and vaccine safety research because it controls for biases inherent to observational research while still providing results that are generalizable to 'real-world' use. To evaluate whether LSTs are used for comparative safety evaluation and if the design is, in fact, advantageous compared with other designs, we conducted a review of the published literature (1949 through 31 December 2010) and the ClinicalTrials.gov registry (2000 through 31 December 2010). Thirteen ongoing or completed safety LSTs were identified. The design has rarely been used in comparative drug safety research, which is due to the operational, financial and scientific hurdles of implementing the design. The studies that have been completed addressed important clinical questions and, in some cases, led to re-evaluation of medical practice. We conclude the design has demonstrated utility for comparative safety research of medicines and vaccines if the necessary scientific and operational conditions for its use are met.

  14. Chemical Frustration. A Design Principle for the Discovery of New Complex Alloy and Intermetallic Phases, Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Fredrickson, Daniel C [Univ. of Wisconsin, Madison, WI (United States)

    2015-06-23

    Final technical report for "Chemical Frustration: A Design Principle for the Discovery of New Complex Alloy and Intermetallic Phases" funded by the Office of Science through the Materials Chemistry Program of the Office of Basic Energy Sciences.

  15. Microgrid Design, Development and Demonstration - Final Report for Phase I and Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Bose, Sumit; Krok, Michael

    2011-02-08

    This document constitutes GE’s final report for the Microgrid Design, Development and Demonstration program for DOE’s Office of Electricity Delivery and Energy Reliability, Award DE-FC02-05CH11349. It contains the final report for Phase I in Appendix I, and the results the work performed in Phase II. The program goal was to develop and demonstrate a Microgrid Energy Management (MEM) framework for a broad set of Microgrid applications that provides unified controls, protection, and energy management. This project contributed to the achievement of the U.S. Department of Energy’s Renewable and Distributed Systems Integration Program goals by developing a fully automated power delivery microgrid network that: - Reduces carbon emissions and emissions of other air pollutants through increased use of optimally dispatched renewable energy, - Increases asset use through integration of distributed systems, - Enhances reliability, security, and resiliency from microgrid applications in critical infrastructure protection, constrained areas of the electric grid, etc. - Improves system efficiency with on-site, distributed generation and improved economic efficiency through demand-side management.

  16. Final safety evaluation report related to the certification of the advanced boiling water reactor design. Volume 1: Main report

    Energy Technology Data Exchange (ETDEWEB)

    1994-07-01

    This safety evaluation report (SER) documents the technical review of the US Advanced Boiling Water Reactor (ABWR) standard design by the US Nuclear Regulatory Commission (NRC) staff. The application for the ABWR design was initially submitted by the General Electric Company, now GE Nuclear Energy (GE), in accordance with the procedures of Appendix O of Part 50 of Title 10 of the Code of Federal Regulations (10 CFR Part 50). Later GE requested that its application be considered as an application for design approval and subsequent design certification pursuant to 10 CFR {section} 52.45. The ABWR is a single-cycle, forced-circulation, boiling water reactor (BWR) with a rated power of 3,926 megawatts thermal (MWt) and a design power of 4,005 MWt. To the extent feasible and appropriate, the staff relied on earlier reviews for those ABWR design features that are substantially the same as those previously considered. Unique features of the ABWR design include internal recirculation pumps, fine-motion control rod drives, microprocessor-based digital logic and control systems, and digital safety systems. On the basis of its evaluation and independent analyses, the NRC staff concludes that, subject to satisfactory resolution of the confirmatory items identified in Section 1.8 of this SER, GE`s application for design certification meets the requirements of Subpart B of 10 CFR Part 52 that are applicable and technically relevant to the US ABWR standard design.

  17. Final safety evaluation report related to the certification of the advanced boiling water reactor design. Volume 2: Appendices

    Energy Technology Data Exchange (ETDEWEB)

    1994-07-01

    This safety evaluation report (SER) documents the technical review of the US Advanced Boiling Water Reactor (ABWR) standard design by the US Nuclear Regulatory Commission (NRC) staff. The application for the ABWR design was initially submitted by the General Electric Company, now GE Nuclear Energy (GE), in accordance with the procedures of Appendix O of Part 50 of Title 10 of the code of Federal Regulations (10 CFR Part 50). Later GE requested that its application be considered as an application for design approval and subsequent design certification pursuant to 10 CFR {section} 52.45. The ABWR is a single-cycle, forced-circulation, boiling water reactor (BWR) with a rated power of 3,926 megawatts thermal (MWt) and a design power of 4,005 MWt. To the extent feasible and appropriate, the staff relied on earlier reviews for those ABWR design features that are substantially the same as those previously considered. Unique features of the ABWR design include internal recirculation pumps, fine-motion control rod drives, microprocessor-based digital logic and control systems, and digital safety systems. On the basis of its evaluation and independent analyses, the NRC staff concludes that, subject to satisfactory resolution of the confirmatory items identified in Section 1.8 of this SER, GE`s application for design certification meets the requirements of Subpart B of 10 CFR Part 52 that are applicable and technically relevant to the US ABWR standard design.

  18. 76 FR 17160 - Office of New Reactors; Final Interim Staff Guidance on the Review of Nuclear Power Plant Designs...

    Science.gov (United States)

    2011-03-28

    ... COMMISSION Office of New Reactors; Final Interim Staff Guidance on the Review of Nuclear Power Plant Designs... Guidance (ISG) DC/COL-ISG-021 titled ``Interim Staff Guidance on the Review of Nuclear Power Plant Designs... Nuclear Power Plants,'' March 2007, Standard Review Plan (SRP), Section 8.3.1 and Sections 9.5.4 through...

  19. Changes to patient limitation for dispensing or prescribing approved narcotic controlled substances for maintenance or detoxification treatment by qualified individual practitioners. Final rule.

    Science.gov (United States)

    2008-05-22

    On September 20, 2007, the Drug Enforcement Administration (DEA) published a Notice of Proposed Rulemaking (NPRM) in the Federal Register (72 FR 53734) proposing to conform its regulations to recent statutory amendments to the Controlled Substances Act that changed certain patient limitations for practitioners who dispense or prescribe certain narcotic drugs for maintenance or detoxification treatment. DEA received one comment in support of this rulemaking. DEA is finalizing the rule as proposed.

  20. Designing smart energy. Final report of the Tekes research project 2007-2008

    Energy Technology Data Exchange (ETDEWEB)

    Peltonen, S.; Pakkanen, M.; Pitkaejaervi, S.; Lautamaeki, S.; Oehman, C.; Baang, M.; Peltola, T.; Broms, L.; Gustafsson, M.-L.

    2009-07-01

    issue from a very fresh angle. This new approach was seen as very welcome by both experts and consumers. One of the most valuable findings was the five energy consumer segments that were identified: Passionate ecologists, Active energy savers, Insensitive energy users, Reluctant energy savers and Unaware energy consumers. These five energy consumer segments clearly differ from each other by their actions, awareness, attitudes and intentions regarding energy saving. In conclusion, several lessons were learned during the Desme project. First of all, it is important to realize that in order to be able to influence in the consumers' energy usage behaviour, it is extremely important to deeply understand their awareness, attitudes and current behaviour. Second, it must be understood that consumers are not a heterogeneous group of people and therefore they need to be approached by different ways and to be offered different solutions. Finally, not only communication, education and more energy efficient technology are needed in order to enhance the consumers to behave in a more energy efficient manner; also innovative and desirable products and services are needed. Industrial design can be a very effective tool for encouraging consumers to think about their energy usage more and use energy less. (orig.)

  1. Grid fault and design-basis for wind turbines. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Hansen, A.D.; Cutululis, N.A.; Markou, H.; Soerensen, Poul; Iov, F.

    2010-01-15

    This is the final report of a Danish research project 'Grid fault and design-basis for wind turbines'. The objective of this project has been to assess and analyze the consequences of the new grid connection requirements for the fatigue and ultimate structural loads of wind turbines. The fulfillment of the grid connection requirements poses challenges for the design of both the electrical system and the mechanical structure of wind turbines. The development of wind turbine models and novel control strategies to fulfill the TSO's requirements are of vital importance in this design. Dynamic models and different fault ride-through control strategies have been developed and assessed in this project for three different wind turbine concepts (active stall wind turbine, variable speed doublyfed induction generator wind turbine, variable speed multipole permanent magnet wind turbine). A computer approach for the quantification of the wind turbines structural loads caused by the fault ride-through grid requirement, has been proposed and exemplified for the case of an active stall wind turbine. This approach relies on the combination of knowledge from complimentary simulation tools, which have expertise in different specialized design areas for wind turbines. In order to quantify the impact of the grid faults and grid requirements fulfillment on wind turbines structural loads and thus on their lifetime, a rainflow and a statistical analysis for fatigue and ultimate structural loads, respectively, have been performed and compared for two cases, i.e. one when the turbine is immediately disconnected from the grid when a grid fault occurs and one when the turbine is equipped with a fault ride-through controller and therefore it is able to remain connected to the grid during the grid fault. Different storm control strategies, that enable variable speed wind turbines to produce power at wind speeds higher than 25m/s and up to 50m/s without substantially increasing

  2. 9 CFR 317.4 - Labeling approval.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Labeling approval. 317.4 Section 317.4 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... by descriptive language the final colors, or submission with the sketch of previously approved final...

  3. Solar Pilot Plant Phase I, detailed design report: thermal storage subsystem research experiment. CDRL Item No. 8 (Approved)

    Energy Technology Data Exchange (ETDEWEB)

    1976-09-17

    The Thermal Storage Subsystem Research Experiment is designed to give maximum information for evaluating the design, performance, and operating parameters of the Barstow Solar Pilot Plant. The experiment is summarized, and the experiment components detail design and integration are described. The experiment test and operation is described which is designed to collect engineering data to allow the design, performance, and operational characteristics to be specified for the Pilot Plant. Appended are: design documentation; pressure drop calculations; materials studies for thermal energy storage; flow charts for data acquisition and control; condenser detail design; instrumentation error analysis; logic diagrams for the control system; literature survey to evaluate the two-phase forced convection heat transfer; and the vaporizer performance model. (LEW)

  4. Trulance Approved for Chronic Constipation

    Science.gov (United States)

    ... news/fullstory_163171.html Trulance Approved for Chronic Constipation Drug designed to stimulate upper gastrointestinal tract To ... U.S. Food and Drug Administration to treat persistent constipation of unknown (idiopathic) cause in adults. Some 42 ...

  5. Final repository for spent nuclear fuel. Underground design Forsmark, Layout D1

    Energy Technology Data Exchange (ETDEWEB)

    Brantberger, Martin; Zetterqvist, Anders [Ramboell Sweden AB, Stockholm (Sweden); Arnbjerg-Nielsen, Torben [Ramboell Denmark A/S, Virum (Denmark); Olsson, Tommy [IandT Olsson AB, Uppsala (Sweden); Outters, Nils [Golder Associates AB, Uppsala (Sweden); Syrjaenen, Pauli [Gridpoint Oy, Helsinki (Sweden)

    2006-04-15

    This report comprises the design step D1 related to the underground design for a deep repository located at the Forsmark site. The design is based on the Site Descriptive Model Forsmark v1.2. All studies have been focussed at an area southeast of the Forsmark nuclear plant, which has been considered to be the most promising area for hosting the repository. SKB has developed guidelines for the design of the repository, which further describes the methodology applied for the studies. From these guidelines the following basic objectives for the design step D1 are summarized: to determine whether the final repository can be accommodated within the studied site; to identify site-specific facility critical issues; to test and evaluate the design methodology; to provide feedback to: the design organisation regarding additional studies that needs to be done; the site investigation and modelling organization regarding further investigations required; and the safety assessment team. The possible locations for a tentative deep repository are analysed in Chapter 3 of the report. The most promising area for the repository (denoted 'priority site') has been defined by SKB to be located southeast of the Forsmark nuclear plant and northwest of the gently dipping deformation zone ZFMNE00A2. Regarding the repository depth, present knowledge acquired from the site investigations indicates that it is possible to locate the repository at all stipulated depths according to SKB, that is between 400 m and 700 m depth. The preliminary assessment made in Chapter 3 clearly demonstrates that the repository can be accommodated within the 'priority site'. The potential to accommodate the repository is essentially the same for both 400 m and 500 m depths. The design of the deposition areas is reported in Chapter 4, which includes the design of layout features for all tunnels and deposition holes, orientation of tunnels, calculation of anticipated loss of deposition holes due

  6. A New Level A Type IVIVC for the Rational Design of Clinical Trials Toward Regulatory Approval of Generic Polymeric Long-Acting Injectables.

    Science.gov (United States)

    Somayaji, Mahadevabharath R; Das, Debarun; Przekwas, Andrzej

    2016-10-01

    Chronic neuropsychiatric disorders and diabetes mellitus affect millions of patients and require long-term supervision and expensive medical care. Although repeated drug administration can help manage these diseases, relapses and re-hospitalization owing to patient non-adherence and reduced therapeutic efficacy remain challenging. In response, long-acting injectables, which provide sustained drug release over longer periods at concentrations close to therapeutic ranges, have been proposed. Recent advancements include polymeric long-acting injectables (pLAIs), in which the active pharmaceutical ingredient (API) is encapsulated within U.S. Food and Drug Administration (FDA)-approved biocompatible polymers, such as poly(lactic-co-glycolic acid), or PLGA. Despite significant progress and development in the global pLAI market, FDA guidance for the approval of complex drug products, such as generic pLAIs, is not clearly defined. Although in vitro to in vivo correlation (IVIVC) can facilitate the identification of critical quality attributes (CQAs), drug formulations, and in vitro test platforms for evaluating drug performance in vivo, the application of IVIVC in order to shortlist time- and resource-intensive clinical trials for generic pLAIs has not been reported. Here, we propose a new Level A Type IVIVC that directly correlates the in vitro outcomes, such as drug dissolution, of candidate generic formulations with the clinical characteristics, such as drug absorption, of a reference listed drug (RLD), to help identify the specific generic pLAI formulations with clinical absorptions that are likely to be similar to that of the RLD, thereby reducing the number of clinical trials required for evaluation of clinical bioequivalence (BE). Therefore, the scope of the proposed method is intended only for the rational design of clinical trials, i.e., to shortlist the specific pLAI generic formulations for clinical BE evaluation, and not necessarily to analyze drug performances

  7. Final definition and preliminary design study for the initial atmospheric cloud physics laboratory, a Spacelab mission payload

    Science.gov (United States)

    1976-01-01

    The following areas related to the final definition and preliminary design study of the initial atmospheric cloud physics laboratory (ACPL) were covered: (1) proposal organization, personnel, schedule, and project management, (2) proposed configurations, (3) study objectives, (4) ACPL experiment program listing and description, (5) mission/flight flexibility and modularity/commonality, (6) study plan, and (7) description of following tasks: requirement analysis and definition task flow, systems analysis and trade studies, subsystem analysis and trade studies, specifications and interface control documents, preliminary design task flow, work breakdown structure, programmatic analysis and planning, and project costs. Finally, an overview of the scientific requirements was presented.

  8. 75 FR 51818 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Science.gov (United States)

    2010-08-23

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from the Los Alamos National Laboratory in Los Alamos, New Mexico, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On July 13, 2010, as provided for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the following class of employees as an addition to the SEC:

  9. 78 FR 3897 - Final Effect of Designation of a Class of Employees for Addition to the Special Exposure Cohort

    Science.gov (United States)

    2013-01-17

    ...HHS gives notice concerning the final effect of the HHS decision to designate a class of employees from the Los Alamos National Laboratory (LANL), in Los Alamos, New Mexico, as an addition to the Special Exposure Cohort (SEC) under the Energy Employees Occupational Illness Compensation Program Act of 2000. On December 7, 2012, as provided for under 42 U.S.C. 7384q(b), the Secretary of HHS designated the following class of employees as an addition to the SEC:

  10. Proposal for the Conceptual Design of Aeronautical Final Assembly Lines Based on the Industrial Digital Mock-Up Concept

    OpenAIRE

    Mas Morate, Fernando; Gómez, Alejandro; Menéndez Cuñado, José Luis; Ríos Chueco, José

    2013-01-01

    Part 1: Keynotes; International audience; The design of a Final Assembly Line (FAL) is carry out in the product industrialization activity. The phase dealing with the definition of conceptual solutions is characterized by depending heavily on the personnel experience and being time-consuming. To enhance such process, it is proposed a development of a knowledge based software application to assist designers in the definition of scenarios and to generate conceptual FAL alternatives. Both the sc...

  11. Fort Hood Solar Total Energy Project. Volume II. Preliminary design. Part 1. System criteria and design description. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1979-01-01

    This volume documents the preliminary design developed for the Solar Total Energy System to be installed at Fort Hood, Texas. Current system, subsystem, and component designs are described and additional studies which support selection among significant design alternatives are presented. Overall system requirements which form the system design basis are presented. These include program objectives; performance and output load requirements; industrial, statutory, and regulatory standards; and site interface requirements. Material in this section will continue to be issued separately in the Systems Requirements Document and maintained current through revision throughout future phases of the project. Overall system design and detailed subsystem design descriptions are provided. Consideration of operation and maintenance is reflected in discussion of each subsystem design as well as in an integrated overall discussion. Included are the solar collector subsystem; the thermal storage subsystem, the power conversion sybsystem (including electrical generation and distribution); the heating/cooling and domestic hot water subsystems; overall instrumentation and control; and the STES building and physical plant. The design of several subsystems has progressed beyond the preliminary stage; descriptions for such subsystems are therefore provided in more detail than others to provide complete documentation of the work performed. In some cases, preliminary design parameters require specific verificaton in the definitive design phase and are identified in the text. Subsystem descriptions will continue to be issued and revised separately to maintain accuracy during future phases of the project. (WHK)

  12. Improved final doublet designs for the ILC baseline small crossing angle scheme

    CERN Document Server

    Appleby, R

    2006-01-01

    The ILC baseline consists of two interaction regions, one with a 20mrad crossing angle and the other with a 2mrad crossing angle. It is known that the outgoing beam losses in the final doublet and subsequent extraction line are larger in the 2mrad than in the 20mrad layout. In this work, we exploit NbTi and Nb$_3$Sn superconducting magnet technologies to redesign and optimise the final doublet, with the aim of providing satisfactory outgoing disrupted beam power losses in this region. We present three new final doublet layouts, specifically optimised for the 500 GeV and the 1 TeV machines.

  13. 9 CFR 72.16 - Designated dipping stations to be approved by the Administrator, APHIS on recommendations of...

    Science.gov (United States)

    2010-01-01

    ....16 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS TEXAS (SPLENETIC) FEVER IN... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Designated dipping stations to...

  14. 42 CFR 137.360 - Does the Secretary approve project planning and design documents prepared by the Self-Governance...

    Science.gov (United States)

    2010-10-01

    ... design documents prepared by the Self-Governance Tribe? 137.360 Section 137.360 Public Health PUBLIC... HUMAN SERVICES TRIBAL SELF-GOVERNANCE Construction Roles of the Secretary in Establishing and... documents prepared by the Self-Governance Tribe? The Secretary shall have at least one opportunity...

  15. Aespoe Pillar Stability Experiment. Final experiment design, monitoring results and observations

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Christer [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Eng, Anders [Acuo Engineering AB, Linkoeping (Sweden)

    2005-12-15

    The field part of the Aespoe Pillar Stability Experiment at the Aespoe Hard Rock Laboratory (HRL) was finished in 2004. The experiment was designed to induce and monitor the process of brittle failure, spalling, in a fractured rock mass under controlled conditions. The field part was successfully conducted and a large data set was obtained. This report presents the final design of the experiment, the results of the monitoring, and the observations made during the spalling process and when the spalled rock was removed. When heating of the rock was initiated the rock responded quickly. After only a few days the spalling process was activated in the notch, as indicated by the acoustic emission system, and shortly thereafter displacement readings were recorded. Contraction (radial expansion) of the rock was recorded by several instruments before the notch reached the instrument levels. This contraction is probably the result of a 3D re-distribution of the stresses. The temperature increase in the system was both slower and reached a steady state much earlier than predicted by the numerical models. The propagation of the notch was therefore halted after approximately one month of heating. The power to the electrical heaters was therefore doubled. Spalling then started up again, and in one month's time it had propagated to a depth of approximately five metres in the hole. A second steady state was now reached, but this time the heater power was kept constant for a while to let the rock settle before the confinement pressure was reduced from 700 kPa to 0 in decrements of 50 kPa. The rock mass response to the pressure drop was very limited until the pressure was lowered to approximately 200 kPa (the atmospheric pressure is not included in the given pressure values). Large displacements and a high acoustic emission hit frequency were then measured in the open hole. After the de-pressurization of the confined hole, the heaters were left on for approximately one week

  16. Evaluation of HiPHES convective reformer design alternatives. Phase 2, Final issue

    Energy Technology Data Exchange (ETDEWEB)

    1991-08-01

    Phase I Stone & Webster presented three potential design configurations for a ceramic-tubed steam-methane reformer. These were the Tube-Within-a-Tube (TWIT) design, the Once-Through design, and the Monolith design. Although the TWIT design configuration appeared to be the most viable, the inclusion of a more detailed examination of design alternatives for the HiPHES reformer was deemed appropriate for the Phase II program. Of particular concern was the length of the ceramic tubes required for the TWIT design. To assist in this evaluation, Stone & Webster established a Development Team consisting of specialists in the areas of heat transfer, ceramic materials, exchanger design, vessel design, and potential users. Stone & Webster reviewed the critical areas of concern for a ceramic convective reformer, evaluated competing design configurations, and presented the results to the Development Team. This report presents Stone & Webster`s evaluations and the comments and recommendations of the Development Team. This effort comprised the majority of Task 1 of Phase II of Stone & Webster`s HiPHES project. The design review was executed in parallel with the material coupon screening tests at BP America. The goal of both tasks was to confirm the materials selection and reformer design configuration so that the conditions for the tube and joint tests to be conducted at Oak Ridge National Laboratory (ORNL) could be specified. The ORNL tests are intended to evaluate the reformer design configuration and materials of construction used for the reformer design in Phase II, and to be used in the demonstration unit in Phase III. The Task 1 (Evaluation of Alternative Reformer Designs) effort has identified a preferred design configuration for the proposed ceramic reformer. Additional engineering and material evaluation work is necessary before an operating prototype can be designed.

  17. Inertial Fusion Energy reactor design studies: Prometheus-L, Prometheus-H. Volume 2, Final report

    Energy Technology Data Exchange (ETDEWEB)

    Waganer, L.M.; Driemeyer, D.E.; Lee, V.D.

    1992-03-01

    This report contains a review of design studies for Inertial Confinement reactor. This second of three volumes discussions is some detail the following: Objectives, requirements, and assumptions; rationale for design option selection; key technical issues and R&D requirements; and conceptual design selection and description.

  18. Engineering Design Thinking and Information Gathering. Final Report. Research in Engineering and Technology Education

    Science.gov (United States)

    Mentzer, Nathan

    2011-01-01

    The objective of this research was to explore the relationship between information access and design solution quality of high school students presented with an engineering design problem. This objective is encompassed in the research question driving this inquiry: How does information access impact the design process? This question has emerged in…

  19. Magnetic Fustion Reactor Design Studies Program final report, 1 July 1986--30 September 1986

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-09-30

    This report presents progress reported during the period, 7/1/86 - 9/30/86 for the Technical Support Services (TSS) for the Magnetic Fusion Reactor Design Studies Program. Tasks reported include: systems studies work plan, normalization of reactor design studies, interpretation of design study activities, research and development plan, conference support, and reports generated.

  20. Design for learning – a case study of blended learning in a science unit [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Roslyn Gleadow

    2015-09-01

    Full Text Available Making material available through learning management systems is standard practice in most universities, but this is generally seen as an adjunct to the ‘real’ teaching, that takes place in face-to-face classes. Lecture attendance is poor, and it is becoming increasingly difficult to engage students, both in the material being taught and campus life. This paper describes the redevelopment of a large course in scientific practice and communication that is compulsory for all science students studying at our Melbourne and Malaysian campuses, or by distance education. Working with an educational designer, a blended learning methodology was developed, converting the environment provided by the learning management system into a teaching space, rather than a filing system. To ensure focus, topics are clustered into themes with a ‘question of the week’, a pre-class stimulus and follow up activities. The content of the course did not change, but by restructuring the delivery using educationally relevant design techniques, the content was contextualised resulting in an integrated learning experience. Students are more engaged intellectually, and lecture attendance has improved. The approach we describe here is a simple and effective approach to bringing this university’s teaching and learning into the 21st century.

  1. Design for learning – a case study of blended learning in a science unit [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Roslyn Gleadow

    2015-11-01

    Full Text Available Making material available through learning management systems is standard practice in most universities, but this is generally seen as an adjunct to the ‘real’ teaching, that takes place in face-to-face classes. Lecture attendance is poor, and it is becoming increasingly difficult to engage students, both in the material being taught and campus life. This paper describes the redevelopment of a large course in scientific practice and communication that is compulsory for all science students studying at our Melbourne and Malaysian campuses, or by distance education. Working with an educational designer, a blended learning methodology was developed, converting the environment provided by the learning management system into a teaching space, rather than a filing system. To ensure focus, topics are clustered into themes with a ‘question of the week’, a pre-class stimulus and follow up activities. The content of the course did not change, but by restructuring the delivery using educationally relevant design techniques, the content was contextualised resulting in an integrated learning experience. Students are more engaged intellectually, and lecture attendance has improved. The approach we describe here is a simple and effective approach to bringing this university’s teaching and learning into the 21st century.

  2. Preliminary designs for ocean thermal energy conversion (OTEC) stationkeeping subsystems (SKSS). Task II. Conceptual design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-07-27

    The study is presented in five sections: design loads, conceptual designs, trade studies, cost analysis and concept evaluation and ranking. Extensive appendixes provide back up calculations and data to support the results. Environmental forces and yaw moments acting on the barge and spar in the various design sea states are presented including wave, wind and current effects. A parametric analysis illustrates the impact on holding power requirement of varying the return periods for operational and extreme sea state. The conceptual designs are presented for the barge followed by those for the spar, including configuration definition, performance characteristics, interfaces, areas for development, and deployment scenarios for selected concepts. The concept definition is followed by a set of trade studies that were performed to evaluate candidate anchor types and anchor leg materials. Parametric variations in anchor leg characteristics, wire-rope-to-chain length ratio for example, illustrate the influence of the significant design parameters on performance. An extensive cost analysis of the candidate SKSS concepts is presented, including cost estimates, life cycle cost scenarios leading to expected value of life cycle cost, and cost equivalence of operational failures. An evaluation of the eight SKSS concepts is presented, including assessment of performance and rankings based on risk versus cost and technology development. The appendixes include a report on the Electrical Transmission System interface, wave drift force, typical cost disbursement schedule and computer program listing, the IMODCO conceptual design report, and static configuration results.

  3. Solar Pilot Plant Phase I, detailed design report: collector subsystem research experiment. CDRL Item No. 6 (Approved)

    Energy Technology Data Exchange (ETDEWEB)

    1976-08-31

    The configurations of the experimental heliostat, power and control system, and support elements for the Barstow Solar Pilot Plant are described, and the analytical and experimental determination of performance parameters is discussed. A system analysis is presented, including demonstration of pointing accuracy by error analysis, and demonstration of loop performance by simulation. Engineering model test plans are given that are to evaluate subassemblies, processes, and procedures as well as provide insight into best tests for heliostat subsystem testing. Mirror module test data are analyzed. A comprehensive test plan for the experimental model is presented. Appended are: a heliostat power consumption analysis; collector subsystem research experiment detail specification; structural analysis; solar image analysis; computer and software information; breadboard test data; simulation of the heliostat control loop; mirror module reflectance measurements; plywood frame fixed focus mirror module test data; techniques for redirected image characterization; performance of a meteorological measuring system; and heliostat design data. (LEW)

  4. An ion-optical design study of a carbon-ion rotating gantry with a superconducting final bending magnet

    Energy Technology Data Exchange (ETDEWEB)

    Bokor, J., E-mail: jozef.bokor@stuba.sk; Pavlovič, M.

    2016-03-11

    Ion-optical designs of an isocentric ion gantry with a compact curved superconducting final bending magnet are presented. The gantry is designed for transporting carbon-therapy beams with nominal kinetic energy of 400 MeV/u, which corresponds to the penetration range of C{sup 6+} beam in water of about 28 cm. In contrast to other existing designs, we present a “hybrid” beam transport system containing a single superconducting element – the last bending magnet. All other elements are based on conventional warm technology. Ion-optical properties of such a hybrid system are investigated in case of transporting non-symmetric (i.e. different emittance patterns in the horizontal and vertical plane) beams. Different conditions for transporting the non-symmetric beams are analyzed aiming at finding the optimal, i.e. the most compact, gantry version. The final gantry layout is presented including a 2D parallel scanning. The ion-optical and scanning properties of the final gantry design are described, discussed and illustrated by computer simulations performed by WinAGILE.

  5. An ion-optical design study of a carbon-ion rotating gantry with a superconducting final bending magnet

    Science.gov (United States)

    Bokor, J.; Pavlovič, M.

    2016-03-01

    Ion-optical designs of an isocentric ion gantry with a compact curved superconducting final bending magnet are presented. The gantry is designed for transporting carbon-therapy beams with nominal kinetic energy of 400 MeV/u, which corresponds to the penetration range of C6+ beam in water of about 28 cm. In contrast to other existing designs, we present a ;hybrid; beam transport system containing a single superconducting element - the last bending magnet. All other elements are based on conventional warm technology. Ion-optical properties of such a hybrid system are investigated in case of transporting non-symmetric (i.e. different emittance patterns in the horizontal and vertical plane) beams. Different conditions for transporting the non-symmetric beams are analyzed aiming at finding the optimal, i.e. the most compact, gantry version. The final gantry layout is presented including a 2D parallel scanning. The ion-optical and scanning properties of the final gantry design are described, discussed and illustrated by computer simulations performed by WinAGILE.

  6. Ocean thermal energy conversion (OTEC) power system development. Preliminary design report, Appendices, Part 1 (Final)

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-04

    The objective of this project is the development of a preliminary design for a full-sized, closed cycle, ammonia power system module for the 100 MWe OTEC demonstration plant. In turn, this demonstration plant is to demonstrate, by 1984, the operation and performance of an Ocean Thermal Power Plant having sufficiently advanced heat exchanger design to project economic viability for commercial utilization in the late 1980's and beyond. Included in this power system development are the preliminary designs for a proof-of-concept pilot plant and test article heat exchangers which are scaled in such a manner as to support a logically sequential, relatively low-cost development of the full-scale power system module. The conceptual designs are presented for the demonstration plant power module, the proof-of-concept pilot plant, and for a pair of test article heat exchangers. Costs associated with the design, development, fabrication, checkout, delivery, installation, and operation are included. The accompanying design and producibilty studies on the full-scale power system module project the performance/economics for the commercial plant. This section of the report contains appendices on the developed computer models, water system dynamic studies, miscellaneous performance analysis, materials and processes, detailed equipment lists, turbine design studies, tube cleaner design, ammonia leak detection, and heat exchanger design supporting data. (WHK)

  7. Human-system interface design review guideline -- Process and guidelines: Final report. Revision 1, Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-06-01

    NUREG-0700, Revision 1, provides human factors engineering (HFE) guidance to the US Nuclear Regulatory Commission staff for its: (1) review of the human system interface (HSI) design submittals prepared by licensees or applications for a license or design certification of commercial nuclear power plants, and (2) performance of HSI reviews that could be undertaken as part of an inspection or other type of regulatory review involving HSI design or incidents involving human performance. The guidance consists of a review process and HFE guidelines. The document describes those aspects of the HSI design review process that are important to the identification and resolution of human engineering discrepancies that could adversely affect plant safety. Guidance is provided that could be used by the staff to review an applicant`s HSI design review process or to guide the development of an HSI design review plan, e.g., as part of an inspection activity. The document also provides detailed HFE guidelines for the assessment of HSI design implementations. NUREG-0700, Revision 1, consists of three stand-alone volumes. Volume 1 consists of two major parts. Part 1 describes those aspects of the review process of the HSI design that are important to identifying and resolving human engineering discrepancies. Part 2 contains detailed guidelines for a human factors engineering review which identify criteria for assessing the implementation of an applicant`s or licensee`s HSI design.

  8. 7 CFR 1485.14 - Application approval and formation of agreements.

    Science.gov (United States)

    2010-01-01

    ... opportunity, market strategy and management capability. (b) Approval criteria. In assessing the applications... submitting the signed agreement to the Director, Marketing Operations Staff, FAS, USDA. Final agreement shall... designated individuals and by the participant's Chief Executive Officer to the Director, Marketing Operations...

  9. Reflections on the Final Year Learning Experience--Designing a Capstone Experience

    Science.gov (United States)

    Thomas, Keith; Wong, Kin Chi; Li, Yi Ching; Hung, Ching Yan

    2013-01-01

    Cross-sector educational reform to be implemented in 2012 in Hong Kong (HK) is intended principally to prepare students for the future workplace. One of the explicit requirements for the new four-year undergraduate curriculum is the inclusion of a capstone course for final year students. This paper explores the uptake and reported effect of the…

  10. On the Design of Learning Outcomes for the Undergraduate Engineer's Final Year Project

    Science.gov (United States)

    Thambyah, Ashvin

    2011-01-01

    The course for the final year project for engineering students, because of its strongly research-based, open-ended format, tends to not have well defined learning outcomes, which are also not aligned with any accepted pedagogical philosophy or learning technology. To address this problem, the revised Bloom's taxonomy table of Anderson and…

  11. Systematic Process Synthesis and Design Methods for Cost Effective Waste Minimization. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Biegler, L.T.; Grossmann, I.E.; Westerberg, A.W.

    1998-02-14

    This report focuses on research done over the past four years under the grant with the above title. In addition, the report also includes a brief summary of work done before 1994 under grant DOE-DE-FG02-85ER13396. Finally, a complete list of publications that acknowledge support from this grant is listed at the end.

  12. Pitolisant: First Global Approval.

    Science.gov (United States)

    Syed, Yahiya Y

    2016-09-01

    Pitolisant (Wakix™) is an inverse agonist of the histamine H3 receptor that is being developed by Bioproject. Oral pitolisant is approved in the EU for the treatment of narcolepsy with or without cataplexy in adults. Pitolisant has received a Temporary Authorization of Use in France for this indication in case of treatment failure, intolerance or contraindication to currently available treatment. Pitolisant has orphan drug designation in the EU and the USA. In the pivotal HARMONY I trial, pitolisant significantly decreased excessive daytime sleepiness versus placebo in adults with narcolepsy with or without cataplexy (primary endpoint). Pitolisant also significantly decreased cataplexy rate versus placebo in these patients. This article summarizes the milestones in the development of pitolisant leading to this first approval for narcolepsy.

  13. Final safety evaluation report related to the certification of the Advanced Boiling Water Reactor design. Supplement 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    This report supplements the final safety evaluation report (FSER) for the US Advanced Boiling Water Reactor (ABWR) standard design. The FSER was issued by the US Nuclear Regulatory Commission (NRC) staff as NUREG-1503 in July 1994 to document the NRC staff`s review of the US ABWR design. The US ABWR design was submitted by GE Nuclear Energy (GE) in accordance with the procedures of Subpart B to Part 52 of Title 10 of the Code of Federal Regulations. This supplement documents the NRC staff`s review of the changes to the US ABWR design documentation since the issuance of the FSER. GE made these changes primarily as a result of first-of-a-kind-engineering (FOAKE) and as a result of the design certification rulemaking for the ABWR design. On the basis of its evaluations, the NRC staff concludes that the confirmatory issues in NUREG-1503 are resolved, that the changes to the ABWR design documentation are acceptable, and that GE`s application for design certification meets the requirements of Subpart B to 10 CFR Part 52 that are applicable and technically relevant to the US ABWR design.

  14. Preliminary designs for modular OTEC platform station-keeping subsystems. Final report. MR and S Report No. 6042-6

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-02-29

    This volume of the report presents the results of the third through the sixth tasks of the Station Keeping Subsystem (SKSS) design studies for 10/40 MW/sub e/ capacity OTEC Modular Experiment platforms (MEP). Tasks 3 through 6 are: (3) complete preliminary designs for one SKSS for each of the two platforms (SPAR and BARGE); (4) development and testing recommendations for the MEP SKSS; (5) cost-time analysis; and (6) commercial plant recommendations. The overall conclusions and recommendations for the modular, as well as the commercial, OTEC platform station keeping subsystems are delineated. The basic design assumptions made during the process, the technical approach followed, and the results of design iterations, reliability and performance analyses are given. A complete description of the preliminary design SKSS concept is presented. The summary cost estimates for each of the alternative SKSS concepts considered are presented and a time schedule for the recommended concept is provided. The effects of varying some of the important parameters used in SKSS design on the performance and cost of the mooring system are investigated and results presented. The tests required and other developmental recommendations in order to verify and confirm the basic design assumptions are discussed. Finally, the experience gained in the MEP preliminary designs are extended to future commercial OTEC plants' SKSS designs. (WHK)

  15. Finalization of the conceptual design of the auxiliary circuits for the European test blanket systems

    Energy Technology Data Exchange (ETDEWEB)

    Aiello, A., E-mail: antonio.aiello@enea.it [ENEA UTIS – C.R. Brasimone, Bacino del Brasimone, I-40032 Camugnano, BO (Italy); Ghidersa, B.E. [Karlsruher Institut für Technologie (KIT) – Institut für Neutronenphysik und Reaktortechnik (INR), D-76021 Karlsruhe (Germany); Utili, M. [ENEA UTIS – C.R. Brasimone, Bacino del Brasimone, I-40032 Camugnano, BO (Italy); Vala, L. [Sustainable Energy (SUSEN), Technological Experimental Circuits, Centrum vyzkumu Rez s.r.o. (CV Rez), Hlavni c.p. 130, CZ-250 68 Husinec-Rez (Czech Republic); Ilkei, T. [Institute for Particle and Nuclear Physics, Wigner Research Centre for Physics, Hungarian Academy of Sciences, Budapest H-1525 (Hungary); Di Gironimo, G.; Mozzillo, R.; Tarallo, A. [CREATE/University of Naples Federico II, Department of Industrial Engineering, P.le Tecchio 80, 80125 Naples (Italy); Ricapito, I.; Calderoni, P. [TBM& MD Project, Fusion for Energy, EU Commission, Carrer J. Pla, 2, Building B3, 08019 Barcelona (Spain)

    2015-10-15

    In view of the ITER conceptual design review, the design of the ancillary systems of the European test blanket systems presented in [1] has been updated and made consistent with the ITER requirements for the present design phase. Europe is developing two concepts of TBM, the helium cooled lithium lead (HCLL) and the helium cooled pebble bed (HCPB) one, having in common the cooling media, pressurized helium at 8 MPa [2]. TBS, namely helium cooling system (HCS), coolant purification system (CPS), lead lithium loop and tritium extraction/removal system (TES–TRS) have the purpose to cool down the TBM and to remove tritium to be driven to TEP from breeder and coolant. These systems are placed in port cell 16 (PC#16), chemical and volume control system (CVCS) area and tritium building. Starting from the pre-conceptual design developed in the past, more mature technical interfaces with the ITER facility have been consolidated and iterative design activities were performed to comply with design requirements/specifications requested by IO to conclude the conceptual design phase. In this paper the present status of design of the TBS is presented together with the preliminary integration in ITER areas.

  16. Solar-C Conceptual Spacecraft Design Study: Final Review. Release 2

    Science.gov (United States)

    Hopkins, Randall; Baysinger, Mike; Thomas, Dan; Heaton, Andy; Stough, Rob; Hill, Spencer; Owens, Jerry; Young, Roy; Fabisinski, Leo; Thomas, Scott; Kim, Tony; Cirtain, Jonathan

    2010-01-01

    This briefing package contains the conceptual spacecraft design completed by the Advanced Concepts Office (ED04) in support of the Solar-C Study. The mission is to succeed Hinode (Solar B), and is designed to study the polar regions of the sun. Included in the slide presentation are sections that review the payload data, and overall ground rules and assumptions, mission analysis and trajectory design, the conceptual spacecraft design section includes: (1) Integrated Systems Design, (2) Mass Properties (3) Cost, (4) Solar Sail Systems, (6) Propulsion, (7) Structures, (8) Thermal (9) Power (10) Avionics / GN&C. There are also conclusions and follow-up work that must be done. In the Back-up section there is information about the JAXA H-11A Launch Vehicle, scalability and spiral development, Mass Projections, a comparison of the TRL assessment for two potential vendors of solar sails, and a chart with the mass properties,

  17. Drugs Approved for Melanoma

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Melanoma This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Melanoma Aldesleukin Cobimetinib Cotellic (Cobimetinib) Dabrafenib Dacarbazine DTIC-Dome ( ...

  18. Preliminary designs for ocean thermal energy conversion (OTEC) stationkeeping subsystems (SKSS). Task I. Design requirements. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-06-01

    The results of Task I, Design Requirements, are presented. Environmental conditions for the Punta Tuna, Puerto Rico site are reviewed and synthesized to provide definition of current, wind and wave severity, direction, and occurrence for service, operational, and extreme sea states. SKSS performance requirements, including design life and watch circle, are followed by interface considerations particularly for the electrical transmission riser cable, and design criteria including safety and load factors. The SKSS concepts will be analyzed to evaluate performance, reliability, and cost. Performance analysis conducted included catenary anchor leg static calculations to size components, as well as drag due to environmental loads in the operational and extreme sea states for both ship and spar platforms. Dynamic analyses and trade studies to be conducted in Task II are presented. A reliability and risk assessment analysis of the three basic SKSS types - single-, multiple-, and tension-anchor-leg moors - was completed, indicating that the multiple-anchor-leg/multiple-point rotary or turret moor has the lowest risk-criticality for the ship, while that for the spar is the multiple-anchor-leg/multiple-point moor. The catenary single-anchor-leg/single-point moor has insufficient reliability for both platforms. The life cycle cost analysis methodology, including work breakdown structure, cost estimating, and cost minimization define the approach to costing to be followed throughout the study. The results of these design trades and analyses will first be applied to concept ranking required for recommendation of a SKSS concept for each platform.

  19. Power system development: Ocean Thermal Energy Conversion (OTEC). Preliminary design report: appendices, Part 2 (Final)

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-12-04

    The objective of this project is the development of a preliminary design for a full-sized, closed cycle, ammonia power system module for the 100 MWe OTEC demonstration plant. In turn, this demonstration plant is to demonstrate, by 1984, the operation and performance of an Ocean Thermal Power Plant having sufficiently advanced heat exchanger design to project economic viability for commercial utilization in the late 1980's and beyond. Included in this power system development are the preliminary designs for a proof-of-concept pilot plant and test article heat exchangers which are scaled in such a manner as to support a logically sequential, relatively low-cost development of the full-scale power system module. The conceptual designs are presented for the demonstration plant power module, the proof-of-concept pilot plant, and for a pair of test article heat exchangers. Costs associated with the design, development, fabrication, checkout, delivery, installation, and operation are included. The accompanying design and producibilty studies on the full-scale power system module project the performance/economics for the commercial plant. This section of the report contains appendices on the electrical system, instrumentation and control, ammonia pump evaluation study, ammonia and nitrogen support subsystems, piping and support design calculations, and plant availability. (WHK)

  20. Two neural network algorithms for designing optimal terminal controllers with open final time

    Science.gov (United States)

    Plumer, Edward S.

    1992-01-01

    Multilayer neural networks, trained by the backpropagation through time algorithm (BPTT), have been used successfully as state-feedback controllers for nonlinear terminal control problems. Current BPTT techniques, however, are not able to deal systematically with open final-time situations such as minimum-time problems. Two approaches which extend BPTT to open final-time problems are presented. In the first, a neural network learns a mapping from initial-state to time-to-go. In the second, the optimal number of steps for each trial run is found using a line-search. Both methods are derived using Lagrange multiplier techniques. This theoretical framework is used to demonstrate that the derived algorithms are direct extensions of forward/backward sweep methods used in N-stage optimal control. The two algorithms are tested on a Zermelo problem and the resulting trajectories compare favorably to optimal control results.

  1. Economic Radioisotope Thermoelectric Generator (RTG) study. Volume I. ERTG design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1973-12-01

    The objectives of this study were: (1) to develop and evaluate an ERTG design for a high power, Curium-244 fueled system based on the tubular thermoelectric module technology; (2) to prepare a program plan for the development of a flight qualified ERTG; and (3) to estimate the costs associated with the production of one, ten and twenty flight qualified ERTG's. This volume presents the Reference Design ERTG approach, the results of the engineering trade studies leading to its selection, and the Second Generation ERTG Design proposed for development. (WHK)

  2. Ocean thermal energy conversion (OTEC). Power system development. Preliminary design report, final

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-04

    The preliminary design of the 10 MWe OTEC power module and the 200 kWe test articles is given in detail. System operation and performance; power system cost estimates; 10 MWe heat exchangers; 200 kWe heat exchanger articles; biofouling control;ammonia leak detection, and leak repair; rotating machinery; support subsystem; instrumentation and control; electrical subsystem; installation approach; net energy and resource analysis; and operability, maintainability, and safety are discussed. The conceptual design of the 40 MWe electrical power system includes four or five 10 MWe modules as designed for the 10 MWe pilot plant. (WHK)

  3. SUNSTORE 3. Phase 1. Project design and tender. Final report; SUNSTORE 3. Fase 1. Projektering og udbud. Slutrapport

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, P.A. (PlanEnergi, Skoerping (Denmark)); Moeller Nielsen, C. (Dronninglund Fjernvarme, Dronninglund (Denmark)); Baunwall, M. (NIRAS Aalborg (Denmark)); Munkholt, H. (GG-Construction, Aalborg (Denmark)); Paaske, B. (Teknologisk Institut, AArhus (Denmark)); Schmidt, T. (SOLITES, Stuttgart (Germany))

    2011-03-15

    The objective of the project has been to carry out detailed design and tendering for a heat production plant consisting of: - 35.000 m{sub 2} solar thermal collectors, - 60.000 m{sub 3} pit heat storage, - 3 MW{sub heat} heat pump, covering app. 50% of the heat production at Dronninglund district heating plant (Denmark). The final report for the project includes detailed design of the pit heat storage (a further development of a 10.000 m{sub 3} storage implemented in Marstal) and simulation of the total production system in the simulation software TRNSYS. (ln)

  4. Optimal design and routing of power lines; ecological technical and economic perspectives (OPTIPOL). Final Report, findings 2009 – 2014.

    OpenAIRE

    Bevanger, Kjetil Modolv; Bartzke, Gundula; Brøseth, Henrik; Dahl, Espen Lie; Gjershaug, Jan Ove; Hanssen, Frank Ole; Jacobsen, Karl Otto; Kleven, Oddmund; Kvaløy, Pål; May, Roelof Frans; Nygård, Torgeir; Refsnæs, Steinar; Stokke, Sigbjørn; Thomassen, Jørn; Meås, Roger

    2014-01-01

    Bevanger, K., Bartzke, G., Brøseth, H., Dahl, E.L., Gjershaug, J.O., Hanssen, F., Jacobsen, K.- O., Kleven, O., Kvaløy, P., May, R., Meås, R., Nygård, T., Refsnæs, S., Stokke, S. & Thomassen, J. 2014. Optimal design and routing of power lines; ecological, technical and economic perspectives (OPTIPOL). Final Report; findings 2009–2014. - NINA Report 1012. 92 pp. OPTIPOL was designed by NINA in early 2008, with a particular focus on power lines and wildlife interactions. As soon as ...

  5. Digital Smile Design concept delineates the final potential result of crown lengthening and porcelain veneers to correct a gummy smile.

    Science.gov (United States)

    Trushkowsky, Richard; Arias, David Montalvo; David, Steven

    2016-01-01

    Prior to initiating any treatment, it is necessary to visualize the desired outcomes. It then becomes possible to formulate the steps required to achieve this result. Digital Smile Design (DSD) utilizes patient input and information gathered through diagnostic procedures to create an esthetic treatment scheme. In the case presented here, the NYUCD Esthetic Evaluation Form, intraoral and extraoral photographs, mounted diagnostic casts, physical examination, and radiographs were the diagnostic modalities. The gathered information served as a starting point for a wax-up and intraoral mock-up. This case report demonstrates how the DSD served as a template for crown lengthening procedures and design of the final porcelain veneer restorations.

  6. Pressure Model for the Vacuum System for the Electron Gun and Injector for LCLS Final Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Tung, L S; Eriksson, L

    2006-04-28

    The vacuum system of the injector for the Linac Coherent Light Source (LCLS) has been analyzed and configured by the Lawrence Livermore National Laboratory's New Technologies Engineering Division (NTED) as requested by the SLAC/LCLS program. The vacuum system layout and detailed analyses for the injector are presented in this final design report. The vacuum system was analyzed and optimized using a coupled gas load balance model of sub-volumes of the components to be evacuated.

  7. Engineering at SLAC: Designing and constructing experimental devices for the Stanford Synchrotron Radiation Lightsource - Final Paper

    Energy Technology Data Exchange (ETDEWEB)

    Djang, Austin [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-08-22

    Thanks to the versatility of the beam lines at SSRL, research there is varied and benefits multiple fields. Each experiment requires a particular set of experiment equipment, which in turns requires its own particular assembly. As such, new engineering challenges arise from each new experiment. My role as an engineering intern has been to help solve these challenges, by designing and assembling experimental devices. My first project was to design a heated sample holder, which will be used to investigate the effect of temperature on a sample's x-ray diffraction pattern. My second project was to help set up an imaging test, which involved designing a cooled grating holder and assembling multiple positioning stages. My third project was designing a 3D-printed pencil holder for the SSRL workstations.

  8. Metal wastage design guidelines for bubbling fluidized-bed combustors. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lyczkowski, R.W.; Podolski, W.F.; Bouillard, J.X.; Folga, S.M. [Argonne National Lab., IL (United States)

    1992-11-01

    These metal wastage design guidelines identify relationships between metal wastage and (1) design parameters (such as tube size, tube spacing and pitch, tube bundle and fluidized-bed height to distributor, and heat exchanger tube material properties) and (2) operating parameters (such as fluidizing velocity, particle size, particle hardness, and angularity). The guidelines are of both a quantitative and qualitative nature. Simplified mechanistic models are described, which account for the essential hydrodynamics and metal wastage processes occurring in bubbling fluidized beds. The empirical correlational approach complements the use of these models in the development of these design guidelines. Data used for model and guideline validation are summarized and referenced. Sample calculations and recommended design procedures are included. The influences of dependent variables on metal wastage, such as solids velocity, bubble size, and in-bed pressure fluctuations, are discussed.

  9. 75 FR 52860 - Final Airworthiness Design Standards for Acceptance Under the Primary Category Rule; Orlando...

    Science.gov (United States)

    2010-08-30

    ... Under the Primary Category Rule; Orlando Helicopter Airways (OHA), Inc., Models Cessna 172I, 172K, 172L... Proposed Airworthiness Design Standards for Acceptance Under the Primary Category Rule; Orlando...

  10. 76 FR 66805 - Endangered and Threatened Wildlife and Plants: Final Rulemaking To Designate Critical Habitat for...

    Science.gov (United States)

    2011-10-27

    ... or shelter; (4) Sites for breeding, reproduction, rearing of offspring, germination, or seed... Geographical Area Occupied One of the first steps in the critical habitat designation process is to define...

  11. Design of 3x3 focusing array for heavy ion driver. Final report on CRADA

    Energy Technology Data Exchange (ETDEWEB)

    Martovetsky, N N

    2005-03-30

    This memo presents a design of a 3 x 3 quadrupole array for HIF. It contains 3 D magnetic field computations of the array build with racetrack coils with and without different shields. It is shown that it is possible to have a low error magnetic field in the cells and shield the stray fields to acceptable levels. The array design seems to be a practical solution to any size array for future multi-beam heavy ion fusion drivers.

  12. Thermal-performance analysis and design for a prototype mobile home, Phase 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Faunce, S.F.

    1981-01-01

    The objective of the project is to redesign a popular standard mobile home in order to incorporate passive solar architectural features which will make the house more energy efficient and still affordable. An analysis of the thermal performance of various designs that were considered is presented. The design effort focused on a choice between a design with a clerestory and a design without one. Various factors considered for minimizing the auxiliary energy input and incorporating solar energy are listed and individually discussed briefly. The design factors that were considered in the analysis of the various options are then covered in detail, including: effect of daily outside temperature swings due to climate, orientation effects on heating and cooling, reflective effect of snow and aluminum roofing, optimum number of glazings and night time insulation, direct gain windows, analysis of a configuration with a water wall, minimum allowed infiltration, maximum stagnation temperature of the thermal wall panel, climatic design data, thin wall and/or floor mass thermal storage, heat loss through walls and windows with fuel oil as a cost basis, and energy reference costs. Analyses were based on weather conditions in Louisville, KY and Newark, DE. (LEW)

  13. Conceptual design of a KrF scaling module. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    A conceptual design of an angular multiplexed 50 kJ KrF laser module for Inertial Confinement Fusion is presented. Optical designs for encoding, beam packing and beam transfer between amplifier stages are developed; emphasis is placed on reducing prepulse problems and achieving acceptable optical quality. An axisymmetric optical design is identified as optimum in terms of simplicity, optical quality, cost and alignment. A kinetic code model was developed for the KrF amplifier and was used to derive scaling maps for the 50 kJ module. Attention was given to reducing parasitics, achieving acceptable extraction efficiency and accounting for amplified spontaneous emission effects. The size of the module is constrained by parasitic suppression and damage thresholds; the power gain is constrained by demanding 40% extraction efficiency in a double pass extraction geometry; and, the run time is constrained by the pulsed power technology (PFN or PFL) and acceptable values of g/sub 0/L. The bounds imposed on the design by the pulsed power technology were examined. Both PFLs and PFNs were considered along with their associated diode, hibachi and guide field requirements. A base line design for a 50 kJ module including amplifier staging, layout and overall size is discussed. Cost analysis and scaling for optical components, pulsed power technology and the guide field are also presented.

  14. Ocean Thermal Energy Conversion power system development. Phase I: preliminary design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-04

    Westinghouse has completed the Preliminary Desigh Phase for the Power System Development of the Ocean Thermal Energy Conversion (OTEC) Demonstration Plant project. This study included the development of a preliminary design for a Modular Application scaled power system (10MWe) and Heat Exchanger Test Articles, both based on the concept developed in the Conceptual Design Phase. The results of this study were used to improve the baseline design of the 50MWe module for the Commercial Size Power System, which was recommended for the demonstration plant by the conceptual design study. The 50MWe module was selected since it has the lowest cost, and since its size convincingly demonstrates that future economically viable commercial plants, having reliable operation with credible anticipated costs, are possible. Additional optimization studies on the size of the power system plus hull continue to identify 50MWe as the preferred minimum cost configuration. This study was limited to a closed cycle ammonia power system module, using a seawater temperature difference of 40/sup 0/F, and a surface platform/ship reference hull. This volume presents the preliminary design configuration and system optimization. (WHK)

  15. Ocean Thermal Energy Conversion power system development. Phase I: preliminary design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-04

    Westinghouse has completed the Preliminary Design Phase for the Power System Development of the Ocean Thermal Energy Conversion (OTEC) Demonstration Plant project. This study included the development of a preliminary design for a Modular Application scaled power system (10MWe) and Heat Exchanger Test Articles, both based on the concept developed in the Conceptual Design Phase. The results of this study were used to improve the baseline design of the 50MWe module for the Commercial Size Power System, which was recommended for the demonstration plant by the conceptual design study. The 50MWe module was selected since it has the lowest cost, and since its size convincingly demonstrates that future economically viable commercial plants, having reliable operation with credible anticipated costs, are possible. Additional optimization studies on the size of the power system plus hull continue to identify 50MWe as the preferred minimum cost configuration. This study was limited to a closed cycle ammonia power system module, using a seawater temperature difference of 40/sup 0/F, and a surface platform/ship reference hull. This volume describes system operation, a complete test program to verify mechanical reliability and thermal performance, fabrication and installation operations, and a cost analysis. (WHK)

  16. Electric utility engineer`s FGD manual -- Volume 1: FGD process design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-04

    Part 1 of the Electric Utility Engineer`s Flue Gas Desulfurization (FGD) Manual emphasizes the chemical and physical processes that form the basis for design and operation of lime- and limestone-based FGD systems applied to coal- or oil-fired steam electric generating stations. The objectives of Part 1 are: to provide a description of the chemical and physical design basis for lime- and limestone-based wet FGD systems; to identify and discuss the various process design parameters and process options that must be considered in developing a specification for a new FGD system; and to provide utility engineers with process knowledge useful for operating and optimizing a lime- or limestone-based wet FGD system.

  17. Ocean thermal energy conversion power system development. Final design report: PSD-I, Phase II

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-06-30

    The PSD-I program provides a heat exchanger sytem consisting of an evaporator, condenser and various ancillaries with ammonia used as a working fluid in a closed simulated Rankine cycle. It is to be installed on the Chepachet Research Vessel for test and evaluation of a number of OTEC concepts in a true ocean environment. It is one of several test articles to be tested. Primary design concerns include control of biofouling, corrosion and erosion of aluminum tubes, selection of materials, and the development of a basis for scale-up to large heat exchangers so as to ultimately demonstrate economic feasibility on a commercial scale. The PSD-I test article is devised to verify thermodynamic, environmental, and mechanical performance of basic design concepts. The detailed design, development, fabrication, checklist, delivery, installation support, and operation support for the Test Article Heat Exchangers are described. (WHK)

  18. Severe accident approach - final report. Evaluation of design measures for severe accident prevention and consequence mitigation.

    Energy Technology Data Exchange (ETDEWEB)

    Tentner, A. M.; Parma, E.; Wei, T.; Wigeland, R.; Nuclear Engineering Division; SNL; INL

    2010-03-01

    An important goal of the US DOE reactor development program is to conceptualize advanced safety design features for a demonstration Sodium Fast Reactor (SFR). The treatment of severe accidents is one of the key safety issues in the design approach for advanced SFR systems. It is necessary to develop an in-depth understanding of the risk of severe accidents for the SFR so that appropriate risk management measures can be implemented early in the design process. This report presents the results of a review of the SFR features and phenomena that directly influence the sequence of events during a postulated severe accident. The report identifies the safety features used or proposed for various SFR designs in the US and worldwide for the prevention and/or mitigation of Core Disruptive Accidents (CDA). The report provides an overview of the current SFR safety approaches and the role of severe accidents. Mutual understanding of these design features and safety approaches is necessary for future collaborations between the US and its international partners as part of the GEN IV program. The report also reviews the basis for an integrated safety approach to severe accidents for the SFR that reflects the safety design knowledge gained in the US during the Advanced Liquid Metal Reactor (ALMR) and Integral Fast Reactor (IFR) programs. This approach relies on inherent reactor and plant safety performance characteristics to provide additional safety margins. The goal of this approach is to prevent development of severe accident conditions, even in the event of initiators with safety system failures previously recognized to lead directly to reactor damage.

  19. Design and optimization of wing tips for wind turbines. Final report; Design og optimering af vingetipper for vindmoeller. Slutrapport

    Energy Technology Data Exchange (ETDEWEB)

    Soerensen, J.N.; Shen, W.Z.; Zhu, W.J.; Borbye, J.; Okulov, V.L.; Mikkelsen, R. (DTU Mekanik, Kgs. Lyngby (Denmark)); Gaunaa, M.; Rethore, P.-E.; Soerensen, N.N. (Danmarks Tekniske Univ. Risoe DTU, Afd. for Vindenergi, Roskilde (Denmark))

    2011-03-15

    The aim of the project was to suggest and analyse new shapes of wing tips for wind turbines to optimize their performance. Several simple wing tips and their flow topology were analysed, and the impact of different design variables was determined in order to establish which design has the best effect for the performance. For the numerical flow calculations, primarily the Navier-Stokes code EllipSys was used. As a supplement to the viscous Navier-Stokes calculations, in-viscous calculations were made using a lifting-line theory. This is a simple technique to determine the load distribution along the wing tip in those cases where viscous effects can be neglected. A large part of the project has focused on improving accuracy of the lifting-line method. Besides forming the basis for improved tip configurations, the calculations were also used to improve the so-called tip correction. Based on the numerical results from CFD calculations an improved tip correction was developed. (ln)

  20. Final report of the cooperative study on seismic isolation design. The second stage

    Energy Technology Data Exchange (ETDEWEB)

    Uryu, Mitsuru; Terada, Syuji; Shioya, Tsutomu (and others)

    1999-05-01

    The applicability of the seismic isolation design onto the nuclear fuel facilities, which must clear severe criteria of integrity, has been examined. Following the first stage of the cooperative study, conducted from 1988 to 1991, the second stage included critical vibration testing, seismic observation of seismic isolation building and founded buildings of non-isolation, with the objectives of clarifying the policies on critical design of seismic isolation building. Integrity of the seismic isolation piping system was tested by means of static deformation test, with variable inner water pressure and relative deformation. (Yamamoto, A.)

  1. SP-100 planetary mission/system preliminary design study. Final report, technical information report

    Energy Technology Data Exchange (ETDEWEB)

    Jones, R.M. [ed.

    1986-02-01

    This report contains a discussion on many aspects of a nuclear electric propulsion planetary science mission and spacecraft using the proposed SP-100 nuclear power subsystem. A review of the science rationale for such missions is included. A summary of eleven nuclear electric propulsion planetary missions is presented. A conceptual science payload, mission design, and spacecraft design is included for the Saturn Ring Rendezvous mission. Spacecraft and mission costs have been estimated for two potential sequences of nuclear electric propulsion planetary missions. The integration issues and requirements on the proposed SP-100 power subsystems are identified.

  2. Design of a high activity and selectivity alcohol catalyst. Final status report and summary of accomplishments

    Energy Technology Data Exchange (ETDEWEB)

    Foley, H.C.; Mills, G.A.

    1994-07-15

    This final DOE report for grant award number DE-FG22-90PC 90291 presents the results of our efforts to better understand the Rh-Mo/{gamma}-Al{sub 2}O3 catalytic system for the hydrogenation of carbon monoxide and carbon dioxide to selectively form oxygenated products. The content of this report is divided into three major sections and a fourth, concluding section which addresses our major research accomplishments, as well as documents the most significant publications and presentations associated with this grant. The three main sections which make up the body of this report are presented in the in form of manuscripts which, in turn, summarize our progress in three areas of this project. The three body sections are organized as follows: Section I--Evidence for site isolation in Rh-Mo bimetallic catalysts derived from organometallic clusters; Section II--Surface Chemistry of Rh-Mo/{gamma}-Al{sub 2}O{sub 3}: An analysis of surface acidity; and Section III--Comparative study of Rh/Al{sub 2}O{sub 3} and Rh-Mo/Al{sub 2}O{sub 3} Catalysts. Section IV summarizes major accomplishments. The content of this final report is meant to generally highlight our progress in both characterizing the nature of the Rh-Mo/Al{sub 2}O{sub 3} system and probing its reactivity for insight on the oxygenate synergy present in this class of catalysts.

  3. Design, engineering and evaluation of refractory liners for slagging gasifiers. Final report

    Energy Technology Data Exchange (ETDEWEB)

    deTineo, B J; Booth, G; Firestone, R F; Greaves, M J; Hales, C; Lamoureux, J P; Ledford, R R

    1982-08-01

    The contract for this program was awarded at the end of September 1978. Work was started on 1 October 1978, on Tasks A, B, and E. Task A, Conceptual Liner Designs, and Task B, Test System Design and Construction, were completed. Task C, Liner Tests, and Task D, Liner Design Evaluation, were to begin upon completion of Task B. Task E, Liner Model Development, is inactive after an initial data compilation and theoretical model development effort. It was to be activated as soon as data were available from Task D. Task F, Liner Design Handbook, was active along with Task A since the reports of both tasks were to use the same format. At this time, Tasks C, D, and F are not to be completed since funding of this project was phased out by DOE directive. The refractory text facility, which was constructed, was tested and found to perform satisfactorily. It is described in detail, including a hazard analysis which was performed. (LTN)

  4. Passive solar design strategies: Remodeling guidelines for conserving energy at home. [Final report

    Energy Technology Data Exchange (ETDEWEB)

    1991-12-31

    The idea of passive solar is simple, but applying it effectively does require information and attention to the details of design and construction. Some passive solar techniques are modest and low-cost, and require only small changes in remodeler`s typical practice. At the other end of the spectrum, some passive solar systems can almost eliminate a house`s need for purchased heating (and in some cases, cooling) energy -- but probably at a relatively high first cost. In between are a broad range of energy-conserving passive solar techniques. Whether or not they are cost-effective, practical and attractive enough to offer a market advantage to any individual remodeler depends on very specific factors such as local costs, climate, and market characteristics. Passive solar design strategies: Remodeling Guidelines For Conserving Energy At Homes is written to help give remodelers the information they need to make these decisions. Passive Solar Design Strategies is a package in three basic parts: The Guidelines contain information about passive solar techniques and how they work, and provides specific examples of systems which will save various percentages of energy; The Worksheets offer a simple, fill-in-the-blank method to pre-evaluate the performance of a specific design; The Worked Example demonstrates how to complete the worksheets for a typical residence.

  5. Ocean thermal energy conversion cold water pipe preliminary design project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-11-20

    As part of a DOE goal to develop one or more OTEC Modular Experiment Plants, TRW performed designs, analyses, and evaluations of cold water pipe (CWP) concepts for NOAA. After reviewing the results of the CWP concept selection phase NOAA/DOE selected three concepts for a baseline design: (1) a FRP CWP of sandwich wall construction suspended from the Applied Physics Laboratory/John Hopkins University (APL/JHU) barge at a site 200 miles east of the coast of Brazil using a horizontal deployment scheme (this is TRW's preferred approach); (2) an elastomer CWP suspended from the APL/JHU barge off the southeast coast of Puerto Rico using either a horizontal or vertical deployment scheme; and (3) a polyethylene CWP (single or multiple pipe) suspended from the Gibbs and Cox spar at the Puerto Rico site using a horizontal deployment scheme. TRW has developed a baseline design for each of these configurations. Detailed designs and analyses for the FRP, polyethylene, and elastomer concepts, respectively, are described. A discussion of fabrication plans and processes, schedules for mobilization of facilities and equipment, installation plans, and cost breakdown are given for each concept. (WHK)

  6. Design, engineering and evaluation of refractory liners for slagging gasifiers. Final report

    Energy Technology Data Exchange (ETDEWEB)

    deTineo, B J; Booth, G; Firestone, R F; Greaves, M J; Hales, C; Lamoureux, J P; Ledford, R R

    1982-08-01

    The contract for this program was awarded at the end of September 1978. Work was started on 1 October 1978, on Tasks A, B, and E. Task A, Conceptual Liner Designs, and Task B, Test System Design and Construction, were completed. Task C, Liner Tests, and Task D, Liner Design Evaluation, were to begin upon completion of Task B. Task E, Liner Model Development, is inactive after an initial data compilation and theoretical model development effort. It was to be activated as soon as data were available from Task D. Task F, Liner Design Handbook, was active along with Task A since the reports of both tasks were to use the same format. At this time, Tasks C, D, and F are not to be completed since funding of this project was phased out by DOE directive. The refractory text facility, which was constructed, was tested and found to perform satisfactorily. It is described in detail, including a hazard analysis which was performed. (LTN)

  7. Ocean Thermal Energy Conversion (OTEC) platform configuration and integration. Volume II. Conceptual design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-06-01

    The purpose of this project is to evaluate six candidate hullforms as candidates for the OTEC commercial plant. This volume is a summary of the conceptual design including facility requirements, cost, schedule, and site sensitivity. Two OTEC commercial plant configurations are considered in this study: the ship and the semi-submersible. Engineering drawings are presented. (WHR)

  8. Wildfire ignition resistant home design(WIRHD) program: Full-scale testing and demonstration final report.

    Energy Technology Data Exchange (ETDEWEB)

    Quarles, Stephen, L.; Sindelar, Melissa

    2011-12-13

    The primary goal of the Wildfire ignition resistant home design(WIRHD) program was to develop a home evaluation tool that could assess the ignition potential of a structure subjected to wildfire exposures. This report describes the tests that were conducted, summarizes the results, and discusses the implications of these results with regard to the vulnerabilities to homes and buildings.

  9. Interactive Graphics Simulator: Design, Development, and Effectiveness/Cost Evaluation. Final Report.

    Science.gov (United States)

    Pieper, William J.; And Others

    This study was initiated to design, develop, implement, and evaluate a videodisc-based simulator system, the Interactive Graphics Simulator (IGS) for 6883 Converter Flight Control Test Station training at Lowry Air Force Base, Colorado. The simulator provided a means for performing task analysis online, developing simulations from the task…

  10. TIBER II/ETR final design report: Volume 1, 1. 0 Introduction; 2. 0 plasma engineering

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J.D. (ed.)

    1987-09-01

    This paper discusses the design of the TIBER II tokamak test reactor. Specific topics discussed are the physics objectives for Tiber, magnetics, baseline operating point, pulsed inductive operation, edge physics and impurity control, fueling, disruption control, vertical stability and impurity flow reversal. (LSP)

  11. Modular OTEC platforms, SKSS designs. Volume I. Executive summary. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-02-29

    One of the possible options for generating electrical energy from ocean thermal gradients requires the use of a floating offshore platform. The platform would contain all OTEC (Ocean Thermal Energy Conversion) systems and power cycle components and consist of the hull, seawater, station-keeping, platform service, and mission support subsystems. It would be stationed at one of the designated OTEC sites, and would transmit the generated electricity to the shore power networks by means of an electrical transmission cable. The objective of the present study is to investigate the station-keeping subsystem (SKSS) requirements and develop preliminary SKSS designs for the two Modular Experiment Plant (MEP) candidates of 10/40 MW/sub e/ capacity for deployment at a specific site. The two MEP hull candidates are a Barge type platform and a Spar shaped hull with external heat exchangers. The specific site assigned for this study is Puerto Rico. The preliminary SKSS designs are developed for both platforms as follows: (1) an 8-leg spread catenary mooring system for the Spar, and (2) a 12-leg spread catenary mooring system for the Barge. Applicability of these designs to larger capacity commercial OTEC platforms is also investigated.

  12. Power Electronics Design Laboratory Exercise for Final-Year M.Sc. Students

    Science.gov (United States)

    Max, L.; Thiringer, T.; Undeland, T.; Karlsson, R.

    2009-01-01

    This paper presents experiences and results from a project task in power electronics for students at Chalmers University of Technology, Goteborg, Sweden, based on a flyback test board. The board is used in the course Power Electronic Devices and Applications. In the project task, the students design snubber circuits, improve the control of the…

  13. Workshop on the Design of Sustainable Product Systems and Supply Chains; Final Report,

    Science.gov (United States)

    ABOUT THE WORKSHOP The Workshop on the Design of Sustainable Product Systems and Supply Chains was held September 12–13, 2011 at the U.S. National Science Foundation (NSF) offices in Arlington, Virginia. The Workshop was co-sponsored by the U.S. Environmental Protection Agency (...

  14. Planning, design, and construction of nuclear power plants: an overview. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Rhodes, D.A.; Rad, P.F.

    1977-12-01

    Chapters are included on generation system descriptions and alternative energy sources; load forecasting and growth projections; utility studies, program development, and analytical models; organizational alternatives and contract arrangements; project control in the design and construction phase; site management activities; construction activities; and startup and testing.

  15. Medicare Program; hospital inpatient prospective payment systems for acute care hospitals and the long-term care hospital prospective payment system changes and FY2011 rates; provider agreements and supplier approvals; and hospital conditions of participation for rehabilitation and respiratory care services; Medicaid program: accreditation for providers of inpatient psychiatric services. Final rules and interim final rule with comment period.

    Science.gov (United States)

    2010-08-16

    : We are revising the Medicare hospital inpatient prospective payment systems (IPPS) for operating and capital-related costs of acute care hospitals to implement changes arising from our continuing experience with these systems and to implement certain provisions of the Affordable Care Act and other legislation. In addition, we describe the changes to the amounts and factors used to determine the rates for Medicare acute care hospital inpatient services for operating costs and capital-related costs. We also are setting forth the update to the rate-of-increase limits for certain hospitals excluded from the IPPS that are paid on a reasonable cost basis subject to these limits. We are updating the payment policy and the annual payment rates for the Medicare prospective payment system (PPS) for inpatient hospital services provided by long-term care hospitals (LTCHs) and setting forth the changes to the payment rates, factors, and other payment rate policies under the LTCH PPS. In addition, we are finalizing the provisions of the August 27, 2009 interim final rule that implemented statutory provisions relating to payments to LTCHs and LTCH satellite facilities and increases in beds in existing LTCHs and LTCH satellite facilities under the LTCH PPS. We are making changes affecting the: Medicare conditions of participation for hospitals relating to the types of practitioners who may provide rehabilitation services and respiratory care services; and determination of the effective date of provider agreements and supplier approvals under Medicare. We are also setting forth provisions that offer psychiatric hospitals and hospitals with inpatient psychiatric programs increased flexibility in obtaining accreditation to participate in the Medicaid program. Psychiatric hospitals and hospitals with inpatient psychiatric programs will have the choice of undergoing a State survey or of obtaining accreditation from a national accrediting organization whose hospital accreditation

  16. Design trends and operating problems in combustion modification of industrial boilers. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Locklin, D.W.; Krause, H.H.; Putnam, A.A.; Kropp, E.L.; Reid, W.T.

    1974-04-01

    The report gives results of an air pollution emissions control study to: characterize the current field population of industrial boilers; identify trends in boiler design; and assess operating problems associated with combustion modification. Statistics were analyzed to describe the field population and recent sales trends for firetube and watertube industrial boilers in the range from 10 million to 500 million Btu/hr. Boiler capacity, design type, mode of direction, primary and secondary fuels, firing method (for coal), industrial classification, and geographic region of the boiler installation were all considered. When combustion modifications are used to control nitrogen oxide emissions from industrial boilers, practical operating problems may arise, namely: fireside corrosion and deposits on boiler tubes; and flame instability, including blow-off, flashback, combustion-driven oscillations, and combustion noise or roar. These problems were assessed and research needs were identified in relation to such combustion modifications as low-excess-air operation, staged combustion, and fluegas recirculation. (GRA)

  17. Final design of the grism cryogenic mount for the Euclid-NISP mission

    Science.gov (United States)

    Rossin, Christelle; Costille, Anne; Caillat, Amandine; Pascal, Sandrine; Sanchez, Patrice; Foulon, Benjamin; Vives, Sebastien; Zavattini, Lorenzo; Moroni, Andrea; Radaelli, Paolo

    2016-07-01

    The grism mount design for the Euclid-NISP mission was studied to maintain optical performances and alignment at cryogenic temperature, and to survive to launch vibrations. An Invar mount with strong weight-relief bonded to the Silica grism through tangential blades has been designed. In spring 2015 we proceeded to thermal cycling and vibration tests to successfully qualify the Grism Engineering Model in the Euclid space environment. Thanks to detailed Finite Element analyses, we correlated simulations and tests. Now that phase C began, we are manufacturing the Engineering and Qualification Model and the four Flight Models. Thus, random coupled analyses of the grisms on the complete wheel assembly and impact of interface preloads on the grism behavior have also been studied.

  18. Designing macromolecular electron delivery systems for artificial biocatalysis. Final report, 1994--1997

    Energy Technology Data Exchange (ETDEWEB)

    Beratan, D.N.

    1997-10-01

    This research focuses on the following four areas: multi-electron transfer processes; coupled quantum/molecular dynamics studies of protein electron transfer; quantum mechanical studies of DNA electron transfer processes; and inverse design of new materials. A theory for two-electron transfer reactions in Debye solvents was developed. The electron transfer processes are described in terms of diffusional motion along a one-dimensional reaction coordinate with tunneling transitions at the intersection points of the parabolas. Coupled quantum mechanics and molecular dynamics simulations were performed to investigate the role of secondary structure and small geometrical fluctuations on the long range electronic coupling in peptides. An inverse molecular design strategy was developed to assist in the development of new molecules with optimized properties.

  19. Integrated coal preparation and CWF processing plant: Conceptual design and costing. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    McHale, E.T.; Paul, A.D.; Bartis, J.T. [Science Applications International Corp., McLean, VA (United States); Korkmaz, M. [Roberts and Schaefer Co., Salt Lake City, UT (United States)

    1992-12-01

    At the request of the US Department of Energy (DOE), Pittsburgh Energy Technology Center, a study was conducted to provide DOE with a reliable, documented estimate of the cost of producing coal-water fuel (CWF). The approach to the project was to specify a plant capacity and location, identify and analyze a suitable coal, and develop a conceptual design for an integrated coal preparation and CWF processing plant. Using this information, a definitive costing study was then conducted, on the basis of which an economic and sensitivity analysis was performed utilizing a financial evaluation model to determine a price for CWF in 1992. The design output of the integrated plant is 200 tons of coal (dry basis) per hour. Operating at a capacity factor of 83 percent, the baseline design yields approximately 1.5 million tons per year of coal on a dry basis. This is approximately equivalent to the fuel required to continuously generate 500 MW of electric power. The CWF produced by the plant is intended as a replacement for heavy oil or gas in electric utility and large industrial boilers. The particle size distribution, particularly the top size, and the ash content of the coal in the CWF are specified at significantly lower levels than is commonly found in typical pulverized coal grinds. The particle top size is 125 microns (vs typically 300m{mu} for pulverized coal) and the coal ash content is 3.8 percent. The lower top size is intended to promote complete carbon burnout at less derating in boilers that are not designed for coal firing. The reduced mineral matter content will produce ash of very fine particle size during combustion, which leads to less impaction and reduced fouling of tubes in convective passages.

  20. DIDET: Digital Libraries for Distributed, Innovative Design Education and Teamwork. Final Project Report

    OpenAIRE

    Breslin, Caroline; Grierson, Hilary

    2008-01-01

    The central goal of the DIDET Project was to enhance student learning opportunities by enabling them to partake in global, team based design engineering projects, in which they directly experience different cultural contexts and access a variety of digital information sources via a range of appropriate technology. To achieve this overall project goal, the project delivered on the following objectives: 1. Teach engineering information retrieval, manipulation, and archiving skills to student...

  1. The Human Powered Submarine Team of Virginia Tech Propulsion System Design Final Report

    Science.gov (United States)

    An, Eric; Bennett, Matt; Callis, Ron; Chen, Chester; Lee, John; Milan-Williams, Kristy

    1999-01-01

    The Human Powered Submarine Team has been in existence at Virginia Tech since its conception in 1993. Since then, it has served as a way for engineering students from many different disciplines to implement design conception and realization. The first submarine built was Phantom 1, a two-man submarine made of fiberglass. After construction was complete, Phantom 1 was ready for racing, but, unfortunately, suffered fatal problems come race time. The submarine team slowed down a bit after experiencing racing problems, but was revived in 1995 when design efforts for a new two-man submarine, the Phantom 2 commence. The propulsion system consisted of a chain and gear drive system using an ultra-light helicopter tail rotor for a propeller. Although the team learned valuable lessons as a result of Phantom 1's problems, Phantom 2 still experiences problems at races. After various parts of Phantom 2 are redesigned, it is once again ready for racing and proves that the redesign was well worth the time and effort. In 1997, Phantom 2 not only finishes its first race, held in San Diego, California, but comes in third. This success sparks yet another revival of the submarine team and design for the team's current project, the Phantom 3, a one-man submarine, is started. In 1998, the plug for Phantom 3 is built and the hull is constructed. With so many past problems from which to learn, Phantom 3 promises to be the fastest and best-designed submarine the team has developed thus far. The current speed world-record is 7 knots.

  2. Finalizing the Dtag: implementation and testing of design improvements for reliability and availability

    Science.gov (United States)

    2016-10-14

    PROJECT NUMBER K. Alex Shorter, University of Michigan 13039100 Tom Hurst, Woods Hole Oceanographic Institution Se. TASK NUMBER Mark Johnson...uu 18. NUMBER OF PAGES 10 19a. NAME OF RESPONSIBLE PERSON Tom Hurst 19b. TELEPHONE NUMBER (Include area code) 508-289-2906 Standard Form 298...of design improvements for reliability and availability K. Alex Shorter, University of Michigan, Ann Arbor, Ml481 04 Tom Hurst, Woods Hole

  3. Supercritical water oxidation of colored smoke, dye, and pyrotechnic compositions. Final report: Pilot plant conceptual design

    Energy Technology Data Exchange (ETDEWEB)

    LaJeunesse, C.A.; Chan, Jennifer P.; Raber, T.N.; Macmillan, D.C.; Rice, S.F.; Tschritter, K.L.

    1993-11-01

    The existing demilitarization stockpile contains large quantities of colored smoke, spotting dye, and pyrotechnic munitions. For many years, these munitions have been stored in magazines at locations within the continental United States awaiting completion of the life-cycle. The open air burning of these munitions has been shown to produce toxic gases that are detrimental to human health and harmful to the environment. Prior efforts to incinerate these compositions have also produced toxic emissions and have been unsuccessful. Supercritical water oxidation (SCWO) is a rapidly developing hazardous waste treatment method that can be an alternative to incineration for many types of wastes. The primary advantage SCWO affords for the treatment of this selected set of obsolete munitions is that toxic gas and particulate emissions will not occur as part of the effluent stream. Sandia is currently designing a SCWO reactor for the US Army Armament Research, Development & Engineering Center (ARDEC) to destroy colored smoke, spotting dye, and pyrotechnic munitions. This report summarizes the design status of the ARDEC reactor. Process and equipment operation parameters, process flow equations or mass balances, and utility requirements for six wastes of interest are developed in this report. Two conceptual designs are also developed with all process and instrumentation detailed.

  4. Ocean thermal energy conversion cold water pipe preliminary design project. Appendices to final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-11-20

    NOAA/DOE has selected three concepts for a baseline design of the cold water pipe (CWP) for OTEC plants: (1) a FRP CWP of sandwich wall construction suspended from the Applied Physical Laboratory/John Hopkins University (APL/JHU) barge at a site 200 miles east of the coast of Brazil using a horizontal deployment scheme; (2) an elastomer CWP suspended from the APL/JHU barge off the southeast coast of Puerto Rico using either a horizontal or vertical deployment scheme; and (3) a polyethylene CWP (single or multiple pipe) suspended from the Gibbs and Cox spar at the Puerto Rico site using a horizontal deployment scheme. TRW has developed a baseline design for each of these configurations. This volume of the report includes the following appendices: (A) fiberglass reinforced plastic cold water pipe (specification and drawingss); (B) specification for polyethylene CWP; (C) elastomer pipe drawings; (D) drawings for OTEC 10/40 hull/CWP transitions; (E) structural design of OTEC 10/40 CWP support and CWP transitions; (F) universal transition joint for CWP; (G) dynamic spherical seal of CWP; (H) at-sea deployment loads - surface towing loads; (I) OTEC 10/40 CWP deployment up-ending loads; (J) cost estimates for OTEC 10/40 hull/CWP transitions; and (K) OTEC 10/40 CWP deployment scenario and cost estimate. (WHK)

  5. Design of passive piezoelectric damping for space structures. Final Report Ph.D. Thesis

    Science.gov (United States)

    Hagood, Nesbitt W., IV; Aldrich, Jack B.; Vonflotow, Andreas H.

    1994-01-01

    Passive damping of structural dynamics using piezoceramic electromechanical energy conversion and passive electrical networks is a relatively recent concept with little implementation experience base. This report describes an implementation case study, starting from conceptual design and technique selection, through detailed component design and testing to simulation on the structure to be damped. About 0.5kg. of piezoelectric material was employed to damp the ASTREX testbed, a 500kg structure. Emphasis was placed upon designing the damping to enable high bandwidth robust feedback control. Resistive piezoelectric shunting provided the necessary broadband damping. The piezoelectric element was incorporated into a mechanically-tuned vibration absorber in order to concentrate damping into the 30 to 40 Hz frequency modes at the rolloff region of the proposed compensator. A prototype of a steel flex-tensional motion amplification device was built and tested. The effective stiffness and damping of the flex-tensional device was experimentally verified. When six of these effective springs are placed in an orthogonal configuration, strain energy is absorbed from all six degrees of freedom of a 90kg. mass. A NASTRAN finite element model of the testbed was modified to include the six-spring damping system. An analytical model was developed for the spring in order to see how the flex-tensional device and piezoelectric dimensions effect the critical stress and strain energy distribution throughout the component. Simulation of the testbed demonstrated the damping levels achievable in the completed system.

  6. Conceptual design and systems analysis of photovoltaic power systems. Final report. Volume III(2). Technology

    Energy Technology Data Exchange (ETDEWEB)

    Pittman, P.F.

    1977-05-01

    Conceptual designs were made and analyses were performed on three types of solar photovoltaic power systems. Included were Residential (1 to 10 kW), Intermediate (0.1 to 10 MW), and Central (50 to 1000 MW) Power Systems to be installed in the 1985 to 2000 time period. The following analyses and simulations are covered: residential power system computer simulations, intermediate power systems computer simulation, central power systems computer simulation, array comparative performance, utility economic and margin analyses, and financial analysis methodology.

  7. OTEC heat exchanger design and producibility study. Part C. Appendixes G thru J. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1976-10-28

    Study results of a preliminary design and manufacturing study of 25-MW/sub e/ aluminium-tubed and titanium-tubed heat exchangers and 5-MW/sub e/ subscale heat exchangers for ocean thermal energy conversion are reported. Subcontractor engineering efforts are described including computer printout sheets from the optimization program; structural analysis of the pressure vessels, heat exchanger tubing, shell to tubesheet transition ring, vapor ports, and concrete pressure vessels; magnaforming of tube-to-tubesheets in aluminium; and explosion bonding and propellant swagging of tubes to tubesheets. (WHK)

  8. IFMIF : International Fusion Materials Irradiation Facility Conceptual Design Activity: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Martone, M. [ENEA, Centro Ricerche Frascati, Rome (Italy)

    1997-01-01

    This report documents the results of the Conceptual Design Activity (CDA) on the International Fusion Materials Irradiation Facility (IFMIF), conducted during 1995 and 1996. The activity is under the auspices of the International Energy Agency (IEA) Implementing Agreement for a Programme of Research and Development on Fusion Materials. An IEA Fusion Materials Executive Subcommittee was charged with overseeing the IFMIF-CDA work. Participants in the CDA are the European Union, Japan, and the United States, with the Russian Federation as an associate member.

  9. Orbital Transfer Vehicle Oxygen Turbopump Technology. Final Report, Volume 1. Design, Fabrication, and Hydrostatic Bearing Testing

    Science.gov (United States)

    1990-12-01

    cc c 58 uju CD C:> ɘ CDC L.) C) 0 crc> 01 2Li L-1 c-.l0 I CD C.- 2.5,Detail Design, cont. assembly error . The most sensitive area for contact is the...exit ports sealed. All transducers sensed within their typi- cal error tolerance at the low pressures being used in the initial tests. Chilldown tests...exterior temp. at turbine TIPO OF (0.25,0) bearing IPmp bearing exit tenperature TPBEC OF PBEI Pmp bearing exit temperature TPBEC OF PBE2 SPump bearing

  10. Design and higher order optimisation of final focus systems for linear colliders

    OpenAIRE

    Marín Lacoma, Eduardo

    2012-01-01

    The accelerator and particle physics communities are considering a lepton Linear Collider LC as the most appropriate machine to carry out high precision particle physics research in the TeV energy regime. The Compact Linear Collider CLIC and the International Linear Collider ILC are the two proposals for the future e+e- LC. Both designs achieve a luminosity L above 10^(34) cm-2 s-1 at the interaction point IP, satisfying the particle physics requirements. The LC consists of different syste...

  11. Conceptual design and systems analysis of photovoltaic power systems. Volume II. Systems. Revised final report

    Energy Technology Data Exchange (ETDEWEB)

    Pittman, P.F.

    1977-03-01

    Conceptual designs were made and analyses were performed on three types of solar photovoltaic power systems. Included were Residential (1--10 kW), Intermediate (0.1--10 MW), and Central (50--1000 MW) Power Systems to be installed in the 1985 to 2000 time period. Detailed descriptions of each of the three systems studied, descriptions of the necessary subsystems, and discussions of the interfaces between them are presented. Included also are descriptions of system performance and system cost used to perform an economic analysis which assesses the value of each system.

  12. Experimental Design for CMIP6: Aerosol, Land Use, and Future Scenarios Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Arnott, James [AGCI

    2015-10-30

    The Aspen Global Change Institute hosted a technical science workshop entitled, “Experimental design for CMIP6: Aerosol, Land Use, and Future Scenarios,” on August 3-8, 2014 in Aspen, CO. Claudia Tebaldi (NCAR) and Brian O’Neill (NCAR) served as co-chairs for the workshop. The Organizing committee also included Dave Lawrence (NCAR), Jean-Francois Lamarque (NCAR), George Hurtt (University of Maryland), & Detlef van Vuuren (PBL Netherlands Environmental Change). The meeting included the participation of 22 scientists representing many of the major climate modeling centers for a total of 110 participant days.

  13. Stirling engine electric hybrid vehicle propulsion system conceptual design study. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Dochat, G; Artiles, A; Killough, J; Ray, A; Chen, H S

    1978-08-01

    Results of a six-month study to characterize a series Stirling engine electric hybrid vehicle propulsion system are presented. The Stirling engine was selected as the heat conversion element to exploit the high efficiency (> .36), low pollution, multi-fuel and quiet operation of this machine. A free-piston Stirling engine driving a linear alternator in a hermatically sealed enclosure was chosen to gain the reliability, long life, and maintenance free characteristics of a sealed unit. The study performs trade off evaluations, selection of engine, battery, motor and inverter size, optimization of components, and develops a conceptual design and characterization of the total propulsion system. The conclusion of the study is that a Stirling engine electric hybrid propulsion system can be used successfully to augment the battery storage of a passenger vehicle and will result in significant savings of petroleum energy over present passenger vehicles. The performance and range augmentation of the hybrid design results in significant improvements over an all electric vehicle. The hybrid will be capable of performing 99% of the passenger vehicle annual trip distribution requirements with extremely low fuel usage. (TFD)

  14. Molecular Design of Doped Polymers for Thermoelectric Systems-Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Chabinyc, Michael L. [University of California, Santa Barbara; Hawker, Craig J. [University of California, Santa Barbara

    2013-10-09

    The self-assembly of organic semiconducting molecules and polymers is critical for their electrical properties. This project addressed the design of organic semiconductors with novel synthetic building blocks for proton-dopable conducting materials and the molecular order and microstructure of high performance semiconducting polymers blended with charge transfer dopants. Novel azulene donor-acceptor materials were designed and synthesized with unique electronic effects upon protonation to generate charged species in solution. The microstructure and optical properties of these derivatives were examined to develop structure-property relationships. Studies of the microstructure of blends of charge transfer doped semiconducting polymers revealed highly ordered conductive phases in blends. The molecular packing of one blend was studied in detail using a combination of solid-state NMR and x-ray scattering revealing that dopant incorporation is unlikely to be random as assumed in transport models. Studies of the electrical properties of these highly ordered blends revealed a universal trend between the thermopower and electrical conductivity of semiconducting polymers that is independent of the doping mechanism.

  15. Army Gas-Cooled Reactor Systems program: alternator final design report

    Energy Technology Data Exchange (ETDEWEB)

    1964-06-01

    The development and testing of a demonstration brushless alternator for the ML-1 mobile nuclear power plant is described. The brushless concept was selected after it became apparent that a conventional power generator could not satisfy the ML-1 weight and size requirements. The demonstration alternator fabricated and tested under this program did not meet all performance specifications; the efficiency was low and the unit could not be operated for significant periods of time without overheating. However, a large body of useful data was accumulated during the extensive development program. Of special interest are data on the rotor and stator design, the cooling requirements and on the distribution of eddy current losses. Analysis of the data indicates that a brushless alternator, only slightly larger and heavier than was specified for the ML-1, could be developed with a modest additional effort.

  16. Conceptual design and systems analysis of photovoltaic systems. Volume II. Study results. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kirpich, A.

    1977-03-19

    This investigation of terrestrial PV systems considered the technical and economic feasibility for systems in three size categories: a small system of about 12 kW peak output for on-site residential use; a large 1500 MW central power plant contributing to the bulk energy of a utility system power grid; and an intermediate size system of about 250 kW for use on public or commercial buildings. In each category, conceptual designs were developed, performance was analyzed for a range of climatic regions, economic analyses were performed, and assessments were made of pertinent institutional issues. The report consists of three volumes. Volume I contains a Study Summary of the major study results. This volume contains the detailed results pertaining to on-site residential photovoltaic systems, central power plant photovoltaic systems, and intermediate size systems applied to commercial and public buildings. Volume III contains supporting appendix material. (WHK)

  17. Design, Observing and Data Systems, and Final Installation of the NEPTUNE Canada Regional Cabled Ocean Observatory

    Science.gov (United States)

    Barnes, C. R.; Best, M. M.; Johnson, F. R.; Phibbs, P.; Pirenne, B.

    2009-05-01

    NEPTUNE Canada (NC; www.neptunecanada.ca) will complete most of the installation of the world's first regional cabled ocean observatory in late 2009 off Canada's west coast. It will comprise five main observatory nodes (100-2700m water depths) linked by an 800km backbone cable delivering 10kVDC power and 10Gbps communications bandwidth to hundreds of sensors, with a 25-year design life. Infrastructure (100M) and initial operational funding (20M) is secured. University of Victoria (UVic) leads a consortium of 12 Canadian universities, hosts the coastal VENUS cabled observatory, with Ocean Networks Canada (ONC) providing management oversight. Observatory architecture has a trunk and branch topology. Installed in late 2007, the backbone cable loops from/to UVic's Port Alberni shore station. The wet plant's design, manufacture and installation was contracted to Alcatel-Lucent. Each node provides six interface ports for connection of science instrument arrays or extensions. Each port provides dual optical Ethernet links and up to 9kW of electrical power at 400VDC. Junction boxes, designed and built by OceanWorks support up to 10 instruments each and can be daisy- chained. They accommodate both serial and 10/100 Ethernet instruments, and provide a variety of voltages (400V, 48V, 24V, 15V). Backbone equipment has all been qualified and installed; shore station re-equipping is complete; junction boxes are manufactured. A major marine program will deploy nodes and instruments in July-September 2009; instruments to one node will probably be deferred until 2010. Observatory instruments will be deployed in subsurface (boreholes), on seabed, and buoyed through the water column. Over 130 instruments (over 40 different types) will host several hundred sensors; mobile assets include a tethered crawler and a 400m vertical profiler. Experiments will address: earthquake dynamics and tsunami hazards; fluid fluxes in both ocean crust and sediments, including gas hydrates; ocean

  18. Final Report: Enabling Exascale Hardware and Software Design through Scalable System Virtualization

    Energy Technology Data Exchange (ETDEWEB)

    Bridges, Patrick G.

    2015-02-01

    In this grant, we enhanced the Palacios virtual machine monitor to increase its scalability and suitability for addressing exascale system software design issues. This included a wide range of research on core Palacios features, large-scale system emulation, fault injection, perfomrance monitoring, and VMM extensibility. This research resulted in large number of high-impact publications in well-known venues, the support of a number of students, and the graduation of two Ph.D. students and one M.S. student. In addition, our enhanced version of the Palacios virtual machine monitor has been adopted as a core element of the Hobbes operating system under active DOE-funded research and development.

  19. Challenges in spent nuclear fuel final disposal:conceptual design models

    Institute of Scientific and Technical Information of China (English)

    Mukhtar Ahmed RANA

    2008-01-01

    The disposal of spent nuclear fuel is a long-standing issue in nuclear technology. Mainly, UO2 and metallic U are used as a fuel in nuclear reactors. Spent nuclear fuel contains fission products and transuranium elements, which would remain radioactive for 104 to 108 years. In this brief communication, essential concepts and engineering elements related to high-level nuclear waste disposal are described. Conceptual design models are described and discussed considering the long-time scale activity of spent nuclear fuel or high level waste. Notions of physical and chemical barriers to contain nuclear waste are highlightened. Concerns regarding integrity, self-irradiation induced decomposition and thermal effects of decay heat on the spent nuclear fuel are also discussed. The question of retrievability of spent nuclear fuel after disposal is considered.

  20. Final report: Seven-layer membrane electrode assembly - an innovative approach to PEM fuel cell design

    Energy Technology Data Exchange (ETDEWEB)

    Chapman, A.

    2005-07-01

    Costs of materials and fabrication, rather than appropriateness of technology, are the major barriers to the sales of fuel cells. With the objective of reducing costs, potential alternative component materials for (a) the fluid flow plate (FFP) and (b) the gas diffusion layers were investigated. The concept of a 7-layer membrane electrode assembly (MEA), in which components are bonded into a unitised module, was also studied. The advantages of the bonded cell, and the flow field design, are expounded. Low-cost carbon particle composites were developed for the FFPs. The modular 7-layer MEA has an order of magnitude saving over current materials. Overall, the study has led to a greater volumetric power output, lower costs and greater reliability. The work was carried out by Morgan Group Technology Limited and funded by the DTI.

  1. Final Report, Validation of Novel Planar Cell Design for MW-Scale SOFC Power Systems

    Energy Technology Data Exchange (ETDEWEB)

    Swartz, Dr Scott L.; Thrun, Dr Lora B.; Arkenberg, Mr Gene B.; Chenault, Ms Kellie M.

    2012-01-03

    This report describes the work completed by NexTech Materials, Ltd. during a three-year project to validate an electrolyte-supported planar solid oxide fuel cell design, termed the FlexCell, for coal-based, megawatt-scale power generation systems. This project was focused on the fabrication and testing of electrolyte-supported FlexCells with yttria-stabilized zirconia (YSZ) as the electrolyte material. YSZ based FlexCells were made with sizes ranging from 100 to 500 cm2. Single-cell testing was performed to confirm high electrochemical performance, both with diluted hydrogen and simulated coal gas as fuels. Finite element analysis modeling was performed at The Ohio State University was performed to establish FlexCell architectures with optimum mechanical robustness. A manufacturing cost analysis was completed, which confirmed that manufacturing costs of less than $50/kW are achievable at high volumes (500 MW/year).

  2. Wheelchair-mounted robotic arm to hold and move a communication device - final design.

    Science.gov (United States)

    Barrett, Graham; Kurley, Kyle; Brauchie, Casey; Morton, Scott; Barrett, Steven

    2015-01-01

    At the 51st Rocky Mountain Bioengineering Symposium we presented a preliminary design for a robotic arm to assist an individual living within an assistive technology smart home. The individual controls much of their environment with a Dynavox Maestro communication device. However, the device obstructs the individual’s line of site when navigating about the smart home. A robotic arm was developed to move the communication device in and out of the user’s field of view as desired. The robotic arm is controlled by a conveniently mounted jelly switch. The jelly switch sends control signals to a four state (up, off, down, off) single-axis robotic arm interfaced to a DC motor by high power electronic relays. This paper describes the system, control circuitry, and multiple safety features. The arm will be delivered for use later in 2015.

  3. Design, manufacture and evaluation of a hydraulically installed, multi-sampling lysimeter. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Scroppo, J.A.; Scroppo, G.L. [Bladon International, Inc., Oak Brook, IL (United States); Carty, R.H.; Chaimberg, M. [Institute of Gas Technology, Chicago, IL (United States); Timmons, R.D.; O`Donnell, M. [Timco Mfg., Inc., Prairie du Sac, WI (United States)

    1992-06-01

    There is a need for a quick, simple, reliable, and inexpensive on-site method for sampling soil pollutants before they reach the groundwater. Vadose zone monitoring is an important aspect of sound groundwater management. In the vadose zone, where water moves via percolation, this water medium possesses the ability to transfer hazardous wastes to the nation`s groundwater system. Obtaining samples of moisture and contaminants from the vadose zone is necessary if potential problems are to be identified before they reach the water table. Accurate determination of spatial distribution, movement, and concentrations of contaminants is essential to the selection of remediation technologies. There is a need for three-dimentional subsurface characterization technologies to identify the location of hazardous plumes and their migration. Current subsurface characterization methods for dispersed contaminants primarily involve a time consuming, expensive process for drilling wells and taking samples. With no major water flow in the vadose zone, conventional monitoring wells will not function as designed. The multi-sampling lysimeter can be readily linked with physical and chemical sensors for on-site screening. The hydraulically-installed suction lysimeter was capable of extracting soil pore liquid samples from unsaturated test soils without the need to predrill a well. Test results verified that the lysimeters installed with a hydraulic or mechanical ram were able to collect soil pore liquid samples in excess of the amount typically required for monitoring and analysis on a daily basis. Modifications to the prototype design eliminated moving parts and the need for inflatable packers. The elimination of the packer system and the use of porous nickel contributed to increased system ruggedness.

  4. Innovative grinding wheel design for cost-effective machining of advanced ceramics. Phase I, final report

    Energy Technology Data Exchange (ETDEWEB)

    Licht, R.H.; Ramanath, S.; Simpson, M.; Lilley, E.

    1996-02-01

    Norton Company successfully completed the 16-month Phase I technical effort to define requirements, design, develop, and evaluate a next-generation grinding wheel for cost-effective cylindrical grinding of advanced ceramics. This program was a cooperative effort involving three Norton groups representing a superabrasive grinding wheel manufacturer, a diamond film manufacturing division and a ceramic research center. The program was divided into two technical tasks, Task 1, Analysis of Required Grinding Wheel Characteristics, and Task 2, Design and Prototype Development. In Task 1 we performed a parallel path approach with Superabrasive metal-bond development and the higher technical risk, CVD diamond wheel development. For the Superabrasive approach, Task 1 included bond wear and strength tests to engineer bond-wear characteristics. This task culminated in a small-wheel screening test plunge grinding sialon disks. In Task 2, an improved Superabrasive metal-bond specification for low-cost machining of ceramics in external cylindrical grinding mode was identified. The experimental wheel successfully ground three types of advanced ceramics without the need for wheel dressing. The spindle power consumed by this wheel during test grinding of NC-520 sialon is as much as to 30% lower compared to a standard resin bonded wheel with 100 diamond concentration. The wheel wear with this improved metal bond was an order of magnitude lower than the resin-bonded wheel, which would significantly reduce ceramic grinding costs through fewer wheel changes for retruing and replacements. Evaluation of ceramic specimens from both Tasks 1 and 2 tests for all three ceramic materials did not show evidence of unusual grinding damage. The novel CVD-diamond-wheel approach was incorporated in this program as part of Task 1. The important factors affecting the grinding performance of diamond wheels made by CVD coating preforms were determined.

  5. Foundation Heat Exchanger Final Report: Demonstration, Measured Performance, and Validated Model and Design Tool

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, Patrick [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Im, Piljae [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2012-04-01

    (FHX) has been coined to refer exclusively to ground heat exchangers installed in the overcut around the basement walls. The primary technical challenge undertaken by this project was the development and validation of energy performance models and design tools for FHX. In terms of performance modeling and design, ground heat exchangers in other construction excavations (e.g., utility trenches) are no different from conventional HGHX, and models and design tools for HGHX already exist. This project successfully developed and validated energy performance models and design tools so that FHX or hybrid FHX/HGHX systems can be engineered with confidence, enabling this technology to be applied in residential and light commercial buildings. The validated energy performance model also addresses and solves another problem, the longstanding inadequacy in the way ground-building thermal interaction is represented in building energy models, whether or not there is a ground heat exchanger nearby. Two side-by-side, three-level, unoccupied research houses with walkout basements, identical 3,700 ft{sup 2} floor plans, and hybrid FHX/HGHX systems were constructed to provide validation data sets for the energy performance model and design tool. The envelopes of both houses are very energy efficient and airtight, and the HERS ratings of the homes are 44 and 45 respectively. Both houses are mechanically ventilated with energy recovery ventilators, with space conditioning provided by water-to-air heat pumps with 2 ton nominal capacities. Separate water-to-water heat pumps with 1.5 ton nominal capacities were used for water heating. In these unoccupied research houses, human impact on energy use (hot water draw, etc.) is simulated to match the national average. At House 1 the hybrid FHX/HGHX system was installed in 300 linear feet of excavation, and 60% of that was construction excavation (needed to construct the home). At House 2 the hybrid FHX/HGHX system was installed in 360 feet of

  6. Foundation Heat Exchanger Final Report: Demonstration, Measured Performance, and Validated Model and Design Tool

    Energy Technology Data Exchange (ETDEWEB)

    Hughes, Patrick [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); Im, Piljae [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

    2012-01-01

    (FHX) has been coined to refer exclusively to ground heat exchangers installed in the overcut around the basement walls. The primary technical challenge undertaken by this project was the development and validation of energy performance models and design tools for FHX. In terms of performance modeling and design, ground heat exchangers in other construction excavations (e.g., utility trenches) are no different from conventional HGHX, and models and design tools for HGHX already exist. This project successfully developed and validated energy performance models and design tools so that FHX or hybrid FHX/HGHX systems can be engineered with confidence, enabling this technology to be applied in residential and light commercial buildings. The validated energy performance model also addresses and solves another problem, the longstanding inadequacy in the way ground-building thermal interaction is represented in building energy models, whether or not there is a ground heat exchanger nearby. Two side-by-side, three-level, unoccupied research houses with walkout basements, identical 3,700 ft{sup 2} floor plans, and hybrid FHX/HGHX systems were constructed to provide validation data sets for the energy performance model and design tool. The envelopes of both houses are very energy efficient and airtight, and the HERS ratings of the homes are 44 and 45 respectively. Both houses are mechanically ventilated with energy recovery ventilators, with space conditioning provided by water-to-air heat pumps with 2 ton nominal capacities. Separate water-to-water heat pumps with 1.5 ton nominal capacities were used for water heating. In these unoccupied research houses, human impact on energy use (hot water draw, etc.) is simulated to match the national average. At House 1 the hybrid FHX/HGHX system was installed in 300 linear feet of excavation, and 60% of that was construction excavation (needed to construct the home). At House 2 the hybrid FHX/HGHX system was installed in 360 feet of

  7. Final report on the design and development of a Rolling Float Meter for drilling-fluid outflow measurement

    Energy Technology Data Exchange (ETDEWEB)

    Staller, G.E.; Westmoreland, J.J.; Whitlow, G.L.; Wright, E.K.; Glowka, D.A.

    1998-03-01

    Lost circulation, which is the loss of well drilling fluids to the formation while drilling, is a common problem encountered while drilling geothermal wells. The rapid detection of the loss of well drilling fluids is critical to the successful and cost-effective treatment of the wellbore to stop or minimize lost circulation. Sandia National Laboratories has developed an instrument to accurately measure the outflow rate of drilling fluids while drilling. This instrument, the Rolling Float Meter, has been under development at Sandia since 1991 and is now available for utilization by interested industry users. This report documents recent Rolling Float Meter design upgrades resulting from field testing and industry input, the effects of ongoing testing and evaluation both in the laboratory and in the field, and the final design package that is available to transfer this technology to industry users.

  8. Conceptual design of advanced central receiver power systems sodium-cooled receiver concept. Volume 1. Executive summary. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-06-01

    The conceptual design of an advanced central receiver power system using liquid sodium as a heat transport medium has been completed by a team consisting of the Energy Systems Group (prime contractor), McDonnell Douglas, Stearns-Roger, The University of Houston, and Salt River Project. The purpose of this study was to determine the technical and economic advantages of this concept for commercial-scale power plants. This final report covers all tasks of the project. These tasks were as follows: (1) review and analysis of preliminary specification; (2) parametric analysis; (3) select commercial configuration; (4) commercial plant conceptual design; (5) assessment of commercial plant; (6) advanced central receiver power system development plan; (7) program plan; (8) reports and data; (9) program management; and (10) safety analysis. A programmatic overview of the accomplishments of this program is given. The 100-MW conceptual commercial plant, the 281-MW optimum plant, and the 10-MW pilot plant are described. (WHK)

  9. Final report on the design and development of a Rolling Float Meter for drilling-fluid outflow measurement

    Energy Technology Data Exchange (ETDEWEB)

    Staller, G.E.; Westmoreland, J.J.; Whitlow, G.L.; Wright, E.K.; Glowka, D.A.

    1998-03-01

    Lost circulation, which is the loss of well drilling fluids to the formation while drilling, is a common problem encountered while drilling geothermal wells. The rapid detection of the loss of well drilling fluids is critical to the successful and cost-effective treatment of the wellbore to stop or minimize lost circulation. Sandia National Laboratories has developed an instrument to accurately measure the outflow rate of drilling fluids while drilling. This instrument, the Rolling Float Meter, has been under development at Sandia since 1991 and is now available for utilization by interested industry users. This report documents recent Rolling Float Meter design upgrades resulting from field testing and industry input, the effects of ongoing testing and evaluation both in the laboratory and in the field, and the final design package that is available to transfer this technology to industry users.

  10. Final Scientific/Technical Report for "Enabling Exascale Hardware and Software Design through Scalable System Virtualization"

    Energy Technology Data Exchange (ETDEWEB)

    Dinda, Peter August [Northwestern Univ., Evanston, IL (United States)

    2015-03-17

    This report describes the activities, findings, and products of the Northwestern University component of the "Enabling Exascale Hardware and Software Design through Scalable System Virtualization" project. The purpose of this project has been to extend the state of the art of systems software for high-end computing (HEC) platforms, and to use systems software to better enable the evaluation of potential future HEC platforms, for example exascale platforms. Such platforms, and their systems software, have the goal of providing scientific computation at new scales, thus enabling new research in the physical sciences and engineering. Over time, the innovations in systems software for such platforms also become applicable to more widely used computing clusters, data centers, and clouds. This was a five-institution project, centered on the Palacios virtual machine monitor (VMM) systems software, a project begun at Northwestern, and originally developed in a previous collaboration between Northwestern University and the University of New Mexico. In this project, Northwestern (including via our subcontract to the University of Pittsburgh) contributed to the continued development of Palacios, along with other team members. We took the leadership role in (1) continued extension of support for emerging Intel and AMD hardware, (2) integration and performance enhancement of overlay networking, (3) connectivity with architectural simulation, (4) binary translation, and (5) support for modern Non-Uniform Memory Access (NUMA) hosts and guests. We also took a supporting role in support for specialized hardware for I/O virtualization, profiling, configurability, and integration with configuration tools. The efforts we led (1-5) were largely successful and executed as expected, with code and papers resulting from them. The project demonstrated the feasibility of a virtualization layer for HEC computing, similar to such layers for cloud or datacenter computing. For effort (3

  11. Kelly Hot Spring Geothermal Project: Kelly Hot Spring Agricultural Center preliminary design. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    Longyear, A.B. (ed.)

    1980-08-01

    A Phase 1 Preliminary Design, Construction Planning and Economic Analysis has been conducted for the Kelly Hot Spring Agricultural Center in Modoc County, California. The core activity is a 1360 breeding sow, swine raising complex that utilizes direct heat energy from the Kelly Hot Spring geothermal resource. The swine is to be a totally confined operation for producing premium pork in controlled-environment facilities. The complex contains a feed mill, swine raising buildings and a complete waste management facility that produces methane gas to be delivered to a utility company for the production of electricity. The complex produces 6.7 million pounds of live pork (29,353 animals) shipped to slaughter per year; 105,000 cu. ft. of scrubbed methane per day; and fertilizer. Total effluent is less than 200 gpm of agricultural quality-water with full odor control. The methane production rate made possible with geothermal direct heat is equivalent to at least 400 kw continuous. Sale of the methane on a co-generation basis is being discussed with the utility company. The use of geothermal direct heat energy in the complex displaces nearly 350,000 gallons of fuel oil per year. Generation of the biogas displaces an additional 300,000 gallons of fuel oil per year.

  12. Designed supramolecular assemblies for biosensors and photoactive devices. LDRD final report

    Energy Technology Data Exchange (ETDEWEB)

    Song, X.Z.; Shelnutt, J.A.; Hobbs, J.D.; Cesarano, J.

    1997-02-01

    The objective of this project is the development of a new class of supramolecular assemblies for applications in biosensors and biodevices. The supramolecular assemblies are based on membranes and Langmuir-Blodgett (LB) films composed of naturally-occurring or synthetic lipids, which contain electrically and/or photochemically active components. The LB films are deposited onto electrically-active materials (metal, semiconductors). The active components film components (lipo-porphyrins) at the surface function as molecular recognition sites for sensing proteins and other biomolecules, and the porphyrins and other components (e.g., fullerenes) incorporated into the films serve as photocatalysts and vectorial electron-transport agents. Computer-aided molecular design (CAMD) methods are used to tailor the structure of these film components to optimize function. Molecular modeling is also used to predict the location, orientation, and motion of these molecular components within the films. The result is a variety of extended, self-assembled molecular structures that serve as devices for sensing proteins and biochemicals or as other bioelectronic devices.

  13. Final safety analysis report for the Galileo Mission: Volume 1, Reference design document

    Energy Technology Data Exchange (ETDEWEB)

    1988-05-01

    The Galileo mission uses nuclear power sources called Radioisotope Thermoelectric Generators (RTGs) to provide the spacecraft's primary electrical power. Because these generators contain nuclear material, a Safety Analysis Report (SAR) is required. A preliminary SAR and an updated SAR were previously issued that provided an evolving status report on the safety analysis. As a result of the Challenger accident, the launch dates for both Galileo and Ulysses missions were later rescheduled for November 1989 and October 1990, respectively. The decision was made by agreement between the DOE and the NASA to have a revised safety evaluation and report (FSAR) prepared on the basis of these revised vehicle accidents and environments. The results of this latest revised safety evaluation are presented in this document (Galileo FSAR). Volume I, this document, provides the background design information required to understand the analyses presented in Volumes II and III. It contains descriptions of the RTGs, the Galileo spacecraft, the Space Shuttle, the Inertial Upper Stage (IUS), the trajectory and flight characteristics including flight contingency modes, and the launch site. There are two appendices in Volume I which provide detailed material properties for the RTG.

  14. Design, Fabrication, and Certification of Advanced Modular PV Power Systems Final Technical Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Lambarski, T.; Minyard, G. (Solar Electric Specialties Co., Willits, California)

    1998-10-06

    This report describes the overall accomplishments and benefits of Solar Electric Specialties Co. (SES) under this Photovoltaic Manufacturing Technology (PVMaT) subcontract. SES addressed design issues related to their modular autonomous PV power supply (MAPPS) and a mobile photogenset. MAPPS investigations included gel-cell batteries mounted horizontally; redesign of the SES power supply; modified battery enclosure for increased safety and reduced cost; programmable, interactive battery charge controllers; and UL and FM listings. The photogenset systems incorporate generators, battery storage, and PV panels for a mobile power supply. The unit includes automatic oil-change systems for the propane generators, collapsible array mounts for the PV enclosure, and internal stowage of the arrays. Standardizing the products resulted in product lines of MAPPS and Photogensets that can be produced more economically and with shorter lead times, while increasing product quality and reliability. Product assembly and quality control have also been improved and streamlined with the development of standardized assembly processes and QC testing procedures. SES offers the UL-listed MAPPS at about the same price as its previous non-standardized, unlisted products.

  15. Planning for a program design for energy environmental analysis. Final report, draft

    Energy Technology Data Exchange (ETDEWEB)

    Denton, J; Saaty, T; Blair, P; Ma, F; Buneman, P

    1976-04-01

    The objective of the work reported here is to assist BER/ERDA in program planning with respect to a regional assessment study program for energy environmental analysis. The focus of the work was to examine the use of operational gaming fof regional assessment studies. Specific concerns were gaming applications (1) in regional assessment or management and direction of regional assessments; (2) for achieving a higher level of public understanding of environmental, health, and safety problems of energy; (3) with respect to the supply of adequately trained manpower for energy; (4) with respect to computational requirements; and (5) with respect to current state-of-the-art in computer simulation. In order to investigate these concerns and examine the feasibility of using operational gaming in a regional assessment study program, a Regional Energy Environment Game (REEG) was designed and implemented on an IBM 370/168 digital computer employing APL (A Programming Language). The applicability of interactive operational gaming has been demonstrated by the REEG as applied to a region consisting of Delaware, Maryland, New Jersey, Pennsylvania, and the District of Columbia.

  16. Final design of a 24 MW radially-cooled insert for a 45 T hybrid system

    Energy Technology Data Exchange (ETDEWEB)

    Weggel, R.J.; Stejskal, V.; Bobrov, E.; Holowinski, M.; Williams, J.E.C. [M.I.T., Cambridge, MA (United States). Francis Bitter National Magnet Lab.

    1996-07-01

    For the National High Magnetic Field Laboratory the Francis Bitter National Magnet Laboratory has designed and is fabricating a 24 MW radially-cooled insert magnet. It is to add 31 teslas or more to the 14 T of the 616 mm bore superconducting magnet of Hybrid V, a system to generate at least 45 T in a 32 mm bore. The insert embodies many innovations for the sake of housing component commonality, unobstructed access for users, quick installation, efficiency, longevity and burnout isolation, while coping with power densities up to 7 W/mm{sup 3}, heat flux densities to 9 W/mm{sup 2}, water pressures to 40 bars, and fault loads to 3.5 MN. The upper surface of the housing is free of all electrical and hydraulic clutter. The compact coil package plugs in from above. Its three coils are electrically and hydraulically in series-parallel, with inward flow through the outer two coils. High water pressure and short passages give water velocities up to 40 m/s, despite depths of only 0.10 to 0.15 mm, thus achieving outstanding cooling efficiency and a peak temperature of only 68C. Conductors, with strengths to match local stresses, are two thicknesses of copper, three of Be-Cu and two of 24% Ag-Cu. All have excellent combinations of strength and electrical conductivity.

  17. Cardiovascular devices; reclassification of intra-aortic balloon and control systems for acute coronary syndrome, cardiac and non-cardiac surgery, or complications of heart failure; effective date of requirement for premarket approval for intra-aortic balloon and control systems for septic shock or pulsatile flow generation. Final order.

    Science.gov (United States)

    2013-12-30

    The Food and Drug Administration (FDA) is issuing a final order to reclassify intra-aortic balloon and control system (IABP) devices when indicated for acute coronary syndrome, cardiac and non-cardiac surgery, or complications of heart failure, a preamendments class III device, into class II (special controls), and to require the filing of a premarket approval application (PMA) or a notice of completion of a product development protocol (PDP) for IABPs when indicated for septic shock or pulsatile flow generation.

  18. Conceptual design of advanced central receiver power system. Phase I. Executive summary and final report

    Energy Technology Data Exchange (ETDEWEB)

    Tracey, T. R.

    1978-09-01

    The designed system has a net electrical output of 300 MWe and has sufficient heliostats and storage capacity to provide full load operation 24 hours per day at summer solstice. The system consists of nine heliostat fields with 7711 heliostats in each. The heliostats track the sun and direct the solar energy incident on them to one of four cavity apertures located at the top of a 155-meter (510 ft) tower. Inside the cavity the flux is absorbed on panels. The panels are cooled by molten salt that enters the receiver at 561/sup 0/K (550/sup 0/K) and leaves the receiver at 838/sup 0/K (1050/sup 0/F). Salt flowrate is controlled to maintain a constant salt exit temperature at the receiver outlet. The hot salt is pumped to the steam generator and/or the storage system. Hot salt pumped to the storage system is stored for later use by the steam generator. The hot salt pumped to the steam generating system is used by the steam generator to heat boiler feedwater and make 783/sup 0/K (950/sup 0/K), 16.5 MPa (2400 psig) superheated steam for the steam turbine/generator. During the process the hot salt is cooled to 561/sup 0/K (550/sup 0/K). The cold salt is pumped to the bottom of the thermal storage tank and/or back to the receivers. During periods when solar insolation is insufficient for rated operation, energy is extracted from the storage system and used to supply heat to the steam generator. The master control system is computerized and provides operator over-rides that serve as overall plant control. It also provides data display and storage.

  19. Design basis for the copper/steel canister. Stage four. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bowyer, W.H. [Meadow End Farm, Farnham (United Kingdom)

    1998-06-01

    The development of the copper/iron canister which has been proposed by SKB for the containment of high level nuclear waste has been studied from the points of view of choice of materials, manufacturing technology and quality assurance. Cast steel has been rejected in favour of cast iron as a candidate material for the load bearing liner. Nodular (or ductile) iron is selected and this is capable of providing mechanical properties which are equally suitable as those of the originally selected high strength low alloy steel. The material specified for the overpack is Oxygen free copper with 50 ppm of phosphorus added. Corrosion studies supported by SKB indicate that in the absence of mechanical failure or accelerated localised corrosion the overpack should provide corrosion shielding of the canister for its full design life. Published work claiming that the nodular iron liner would have corrosion characteristics similar to the carbon steel which had been examined in depth is flawed since the microstructures of the iron and carbon steel specimens used were not investigated. It is highly unlikely that nodular irons in the form used for the experiments would have similar structures to nodular iron in the canisters by chance. If the overpack were breached during the aerobic period of the repository life then very rapid penetration of the inner liner could occur. It has been recognised that the roll forming method is not suitable for serial production and alternatives are being sought. The electron beam welding process has been explored with tenacity but has so far failed to produce a satisfactory lid weld. A new welder is being developed for supply to the SKB pilot plant where development will be continued. An alternative welding process, friction stir welding, is being examined as a candidate for attaching lids. Surface breaking defects may be detected using eddy current methods but there is currently no reliable way of detecting small sub surface defects in the overpack

  20. 46 CFR 154.1005 - Equipment approval.

    Science.gov (United States)

    2010-10-01

    ... carried. (b) Each submerged cargo pump motor installation must be specially approved by the Commandant (CG... FOR SELF-PROPELLED VESSELS CARRYING BULK LIQUEFIED GASES Design, Construction and Equipment Electrical § 154.1005 Equipment approval. (a) Electrical equipment that is required to be intrinsically safe...

  1. Obinutuzumab breaks through to FDA approval.

    Science.gov (United States)

    2014-01-01

    The U.S. Food and Drug Administration approved the monoclonal antibody obinutuzumab for use with chlorambucil in patients with previously untreated chronic lymphocytic leukemia. The drug is the first to receive approval under the agency's breakthrough therapy designation, created in July 2012.

  2. Nelfinavir: fourth protease inhibitor approved.

    Science.gov (United States)

    1997-01-01

    The Food and Drug Administration (FDA) has granted accelerated approval to nelfinavir in both adult and pediatric formulations. Agouron, the manufacturer, used innovative computerized drug design techniques to discover, design, and refine the nelfinavir molecule. Nelfinavir is marketed under the trade name Viracept, and costs $5,000 per year. Early clinical trials find it to be as powerful as the other protease inhibitors, but with a different resistance profile. The drug has relatively few drug indications; however, several compounds have been contraindicated.

  3. A comprehensive quadratic assignment problem for an integrated layout design of final assembly line and manufacturing feeder cells

    Directory of Open Access Journals (Sweden)

    Masoud Rabbani

    2017-04-01

    Full Text Available Assembly lines and cellular manufacturing systems (CMSs design have been widely used in the literature. However the integration of these manufacturing concepts is neglected in an environment where parts need to be assembled after production in different shops. In this paper, a comprehensive quadratic assignment problem is developed for the assignment of machines of each part manufacturing cell, sub-assembly tasks of each sub-assembly cell as well as the assignment of different cells and final assembly tasks within the shop floor in their relevant predetermined locations. A genetic algorithm (GA as well as a memetic algorithm (MA consisting of the proposed GA and Tabu search (TS algorithm are proposed and implemented on different size numerical examples. The obtained results show the efficiency of both algorithms to reach near optimal solutions compared to the optimal solution of small-sized problems.

  4. Construction and first characterisation of a prototype for the PANDA barrel EMC in a close to final design

    Energy Technology Data Exchange (ETDEWEB)

    Rosenbaum, Christoph; Bremer, Daniel; Diehl, Stefan; Drexler, Peter; Dormenev, Valery; Eissner, Tobias; Kuske, Till; Novotny, Rainer W.; Zaunick, Hans-Georg [2. Physics Institute, University Giessen (Germany); Le Galliard, Christine; Imre, Miktat; Marchand, Dominique; Rosier, Phillippe [IPN Orsay (France); Kavatsyuk, Myroslav [KVI Groningen (Netherlands); Ryantzev, Andrej [IHEP Protvino (Russian Federation); Wieczorek, Peter; Wilms, Andrea [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Collaboration: PANDA-Collaboration

    2014-07-01

    The EMC of the PANDA target spectrometer is one of the central detector components to achieve the physical goals. The barrel part will consist of lead tungstate (PWO) crystals operated at -25 C to achieve the required performance over a wide energy range. To achieve a good energy, position and time resolution, it is necessary to perform detailed tests of prototypes. The most recent one, PROTO120, represents a subsection of the barrel EMC. The design is close to the final concept of the EMC with respect to the detector assembly, cooling circuit and front-end electronics. The conversion of the scintillation light will be performed with two rectangular LAAPD, which are read-out separately via the APFEL-ASIC providing a large dynamic range, low power consumption and the optimized shaping. The talk describes the details of the construction and a first test on the performance based on cosmic muons.

  5. Provisional stenting of coronary bifurcations: insights into final kissing balloon post-dilation and stent design by computational modeling.

    Science.gov (United States)

    Mortier, Peter; Hikichi, Yutaka; Foin, Nicolas; De Santis, Gianluca; Segers, Patrick; Verhegghe, Benedict; De Beule, Matthieu

    2014-03-01

    This study sought to better understand and optimize provisional main vessel stenting with final kissing balloon dilation (FKBD). Main vessel stenting with FKBD is widely used, but many technical variations are possible that may affect the final result. Furthermore, most contemporary stent designs have a large cell size, making the impact of stent platform selection for this procedure unclear. Finite element simulations were used to virtually deploy and post-dilate 3 stent platforms in 3 bifurcation models. Two FKBD strategies were evaluated: simultaneous FKBD (n = 27) and modified FKBD (n = 27). In the simultaneous FKDB technique, both balloons were simultaneously inflated and deflated. In the modified FKBD technique, the side branch balloon was inflated first, then partially deflated, followed by main branch balloon inflation. Modified FKBD results in less ostial stenosis compared with simultaneous FKBD (15 ± 9% vs. 20 ± 11%; p < 0.001) and also reduces elliptical stent deformation (ellipticity index, 1.17 ± 0.05 vs. 1.36 ± 0.06; p < 0.001). The number of malapposed stent struts was not influenced by the FKBD technique (modified FKBD, 6.3 ± 3.6%; simultaneous FKBD, 6.4 ± 3.4%; p = 0.212). Stent design had no significant impact on the remaining ostial stenosis (Integrity [Medtronic, Inc., Minneapolis, Minnesota], 16 ± 11%; Omega [Boston Scientific, Natick, Massachusetts], 17 ± 11%; Multi-Link 8 [Abbott Vascular, Santa Clara, California], 19 ± 8%). The modified FKBD procedure reduces elliptical stent deformation and optimizes side branch access. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  6. Grid-Connected Integrated Community Energy System. Phase II: detailed feasibility analysis and preliminary design. Final report, Stage 2

    Energy Technology Data Exchange (ETDEWEB)

    1978-11-01

    The purpose of this study was to determine the economic and environmental feasibility of a Grid-Connected Integrated Community Energy System (ICES) based on a multifuel (gas, oil, treated solid wastes, and coal) design with which to serve any or all the institutions within the Louisiana Medical Complex in cooperation with the Health Education Authority of Louisiana (HEAL). In this context, a preliminary design is presented which consists of ICES plant description and engineering analyses. This demonstration system is capable of meeting 1982 system demands by providing 10,000 tons of air conditioning and, from a boiler plant with a high-pressure steam capacity of 200,000 lb/h, approximately 125,000 lb/h of 185 psig steam to the HEAL institutions, and at the same time generating up to 7600 kW of electrical power as byproduct energy. The plant will consist of multiple-fuel steam boilers, turbine generator, turbine driven chillers and necessary auxiliaries and ancillary systems. The preliminary design for these systems and for the building to house the central plant systems are presented along with equipment and instrumentation schedules and outline specifications for major components. Costs were updated to reflect revised data. The final preliminary cost estimate includes allowances for contingencies and escalation, as well as cost for the plant site and professional fees. This design is for a facility specifically with coal burning capability, recognizing that it is more capital-intensive than a gas/oil facility. In the opinion of the Louisiana Department of Natural Resources (DNR), the relatively modest allocations made for scrubbing and ash removal involve less than is implied in standard industry (EPRI) cost increments of over 30% for these duties. The preliminary environmental assessment is included. (LCL)

  7. SRC burn test in 700-hp oil-designed boiler. Volume 1. Integrated report. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    1983-09-01

    This burn test program was conducted during the period of August 1982 to February 1983 to demonstrate that Solvent Refined Coal (SRC) products can displace petroleum as a boiler fuel in oil- and gas-designed boilers. The test program was performed at the U.S. Department of Energy's Pittsburgh Energy Technology Center (PETC). Three forms of SRC (pulverized SRC, a solution of SRC dissolved in process-derived distillates, and a slurry of SRC and water) and No. 6 Fuel Oil were evaluated in the 700-hp (30 x 10/sup 6/ Btu/hour) watertube, oil-designed boiler facility at PETC. The test program was managed by the International Coal Refining Company (ICRC) and sponsored by the Department of Energy. Other organizations were involved as necessary to provide the expertise required to execute the test program. This final report represents an integrated overview of the test program conducted at PETC. More detailed information with preliminary data can be obtained from separate reports prepared by PETC, Southern Research Institute, Wheelabrator-Frye, Babcock and Wilcox, and Combustion Engineering. These are presented as Annex Volumes A-F. 25 references, 41 figures, 15 tables.

  8. LIFAC demonstration at Richmond Power and Light Whitewater Valley Unit No. 2. Final report, Volume 1 - public design

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    This report discusses the demonstration of LIFAC sorbent injection technology at Richmond Power and Light`s (RP&L) Whitewater Valley Unit No. 2 under the auspices of the U.S. Department of Energy`s (DOE) Clean Coal Technology Program. LIFAC is a sorbent injection technology capable of removing 75 to 85 percent of a power plant`s SO{sub 2} emissions using limestone at calcium to sulfur molar ratios of between 2 and 2.5. The site of the demonstration is a coal-fired electric utility power plant located in Richmond, Indiana. The project is being conducted by LIFAC North American (LIFAC NA), a joint venture partnership of Tampella Power Corporation and ICF Kaiser Engineers, in cooperation with DOE, RP&L, and several other organizations including the Electric Power Research Institute (EPRI), the State of Indiana, and Black Beauty Coal Company. The purpose of Final Report Volume 1: Public Design is to consolidate, for public use, all design and cost information regarding the LIFAC Desulfurization Facility at the completion of construction and startup.

  9. 8 CFR 207.6 - Control over approved refugee numbers.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Control over approved refugee numbers. 207... ADMISSION OF REFUGEES § 207.6 Control over approved refugee numbers. Current numerical accounting of approved refugees is maintained for each special group designated by the President. As refugee status...

  10. Uranium Mill Tailings Remedial Action Project (UMTRAP), Slick Rock, Colorado, Revision 1. Volume 2, Calculations, Final design for construction

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    Volume two contains calculations for: embankment design--slope stability analysis; embankment design--excavation stability; embankment design--settlement and cover cracking analysis; radon barrier design--statistical analysis of ra-226 concentrations for North Continent and Union Carbide sites; radon barrier design--RAECOM input data; radon barrier design--design thickness; and cover design--frost penetration depth.

  11. A near-peer teaching program designed, developed and delivered exclusively by recent medical graduates for final year medical students sitting the final objective structured clinical examination (OSCE

    Directory of Open Access Journals (Sweden)

    Sobowale Oluwaseun

    2011-03-01

    Full Text Available Abstract Background The General Medical Council states that teaching doctors and students is important for the care of patients. Our aim was to deliver a structured teaching program to final year medical students, evaluate the efficacy of teaching given by junior doctors and review the pertinent literature. Methods We developed a revision package for final year medical students sitting the Objective Structured Clinical Examination (OSCE. The package was created and delivered exclusively by recent medical graduates and consisted of lectures and small group seminars covering the core areas of medicine and surgery, with a focus on specific OSCE station examples. Students were asked to complete a feedback questionnaire during and immediately after the program. Results One hundred and eighteen completed feedback questionnaires were analysed. All participants stated that the content covered was relevant to their revision. 73.2% stated that junior doctors delivered teaching that is comparable to that of consultant - led teaching. 97.9% stated the revision course had a positive influence on their learning. Conclusions Our study showed that recent medical graduates are able to create and deliver a structured, formal revision program and provide a unique perspective to exam preparation that was very well received by our student cohort. The role of junior doctors teaching medical students in a formal structured environment is very valuable and should be encouraged.

  12. Remedial action plan and site design for stabilization of the inactive uranium mill tailings sites at Rifle, Colorado. Volume 2, Appendices D and E: Final report

    Energy Technology Data Exchange (ETDEWEB)

    1992-02-01

    This appendix assesses the present conditions and data gathered about the two inactive uranium mill tailings sites near Rifle, Colorado, and the designated disposal site six miles north of Rifle in the area of Estes Gulch. It consolidates available engineering, radiological, geotechnical, hydrological, meteorological, and other information pertinent to the design of the Remedial Action Plan (RAP). The data characterize conditions at the mill, tailings, and disposal site so that the Remedial Action Contractor (RAC) may complete final designs for the remedial actions.

  13. Hybrid ventilation systems. Principles, design and calculation, case studies. Final report; Hybride Lueftungssysteme. Prinzipien, Planung und Berechnung, Beispiele. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Grundmann, R.; Roloff, J. [and others

    2003-09-01

    This report contains the most important information achieved within the IEA-ECBCS project Annex 35 of the national and international level. The first chapters are a translation of the main parts of the international final report 'Principles of Hybrid Ventilation' (ed. Per Heiselberg). The international report including a CD-ROM is enclosed in this report. Based on a definition of hybrid ventilation it is motivated why to deal with hybrid ventilation. The explanations are underlined by precise data of the investigated case studies. The variety of solutions with hybrid ventilation is large, but there are three main principles, natural and mechanical ventilation, fan-assisted natural ventilation, stack- and wind-assisted mechanical ventilation. A hybrid ventilation systems is most suitable to implement if this idea is taken into account in the early design phases. Therefore decision tools are compiled to make it clear whether a hybrid ventilation concept could be successful under the given conditions or not. Moreover, important aspects of control strategies are summarized, which are crucial for an optimal operation of a hybrid ventilation system. If there is an option for installing a hybrid ventilation system it is necessary to carry out calculations and evaluations during the design phases. The available tools are presented and classified. Beside the substantial data of the case studies of the international project partners the national studies are presented in detail. These are the investigation of an existing hybrid ventilation system in the school building 'Bertolt-Brecht-Gymnasium', Dresden and the development of an innovative hybrid ventilation system at the Fraunhofer-Institute of Building Physics in Holzkirchen. (orig.)

  14. W.A. Parish Post Combustion CO2 Capture and Sequestration Project Final Public Design Report

    Energy Technology Data Exchange (ETDEWEB)

    Armpriester, Anthony [Petra Nova Parish Holdings, Washington, DC (United States)

    2017-02-17

    The Petra Nova Project is a commercial scale post-combustion carbon dioxide capture project that is being developed by a joint venture between NRG Energy (NRG) and JX Nippon Oil and Gas Exploration (JX). The project is designed to separate and capture carbon dioxide from an existing coal-fired unit's flue gas slipstream at NRG's W.A. Parish Generation Station located southwest of Houston, Texas. The captured carbon dioxide will be transported by pipeline and injected into the West Ranch oil field to boost oil production. The project, which is partially funded by financial assistance from the U.S. Department of Energy will use Mitsubishi Heavy Industries of America, Inc.'s Kansai Mitsubishi Carbon Dioxide Recovery (KM-CDR(R)) advanced amine-based carbon dioxide absorption technology to treat and capture at least 90% of the carbon dioxide from a 240 megawatt equivalent flue gas slipstream off of Unit 8 at W.A. Parish. The project will capture approximately 5,000 tons of carbon dioxide per day or 1.5 million tons per year that Unit 8 would otherwise emit, representing the largest commercial scale deployment of post-combustion carbon dioxide capture at a coal power plant to date. The joint venture issued full notice to proceed in July 2014 and when complete, the project is expected to be the world's largest post-combustion carbon dioxide capture facility on an existing coal plant. The detailed engineering is sufficiently complete to prepare and issue the Final Public Design Report.

  15. Design and Evaluation of a Clock Multiplexing Circuit for the SSRL Booster Accelerator Timing System - Final Paper

    Energy Technology Data Exchange (ETDEWEB)

    Araya, Million

    2015-08-21

    SPEAR3 is a 234 m circular storage ring at SLAC’s synchrotron radiation facility (SSRL) in which a 3 GeV electron beam is stored for user access. Typically the electron beam decays with a time constant of approximately 10hr due to electron lose. In order to replenish the lost electrons, a booster synchrotron is used to accelerate fresh electrons up to 3GeV for injection into SPEAR3. In order to maintain a constant electron beam current of 500mA, the injection process occurs at 5 minute intervals. At these times the booster synchrotron accelerates electrons for injection at a 10Hz rate. A 10Hz 'injection ready' clock pulse train is generated when the booster synchrotron is operating. Between injection intervals-where the booster is not running and hence the 10 Hz ‘injection ready’ signal is not present-a 10Hz clock is derived from the power line supplied by Pacific Gas and Electric (PG&E) to keep track of the injection timing. For this project I constructed a multiplexing circuit to 'switch' between the booster synchrotron 'injection ready' clock signal and PG&E based clock signal. The circuit uses digital IC components and is capable of making glitch-free transitions between the two clocks. This report details construction of a prototype multiplexing circuit including test results and suggests improvement opportunities for the final design.

  16. Final design and progress of WEAVE: the next generation wide-field spectroscopy facility for the William Herschel Telescope

    Science.gov (United States)

    Dalton, Gavin; Trager, Scott; Abrams, Don Carlos; Bonifacio, Piercarlo; Aguerri, J. Alfonso L.; Middleton, Kevin; Benn, Chris; Dee, Kevin; Sayède, Frédéric; Lewis, Ian; Pragt, Johannes; Pico, Sergio; Walton, Nic; Rey, Jeurg; Allende Prieto, Carlos; Peñate, José; Lhome, Emilie; Agócs, Tibor; Alonso, José; Terrett, David; Brock, Matthew; Gilbert, James; Schallig, Ellen; Ridings, Andy; Guinouard, Isabelle; Verheijen, Marc; Tosh, Ian; Rogers, Kevin; Lee, Martin; Steele, Iain; Stuik, Remko; Tromp, Niels; Jaskó, Attila; Carrasco, Esperanza; Farcas, Szigfrid; Kragt, Jan; Lesman, Dirk; Kroes, Gabby; Mottram, Chris; Bates, Stuart; Rodriguez, Luis Fernando; Gribbin, Frank; Delgado, José Miguel; Herreros, José Miguel; Martin, Carlos; Cano, Diego; Navarro, Ramon; Irwin, Mike; Lewis, Jim; Gonzalez Solares, Eduardo; Murphy, David; Worley, Clare; Bassom, Richard; O'Mahoney, Neil; Bianco, Andrea; Zurita, Christina; ter Horst, Rik; Molinari, Emilio; Lodi, Marcello; Guerra, José; Martin, Adrian; Vallenari, Antonella; Salasnich, Bernardo; Baruffolo, Andrea; Jin, Shoko; Hill, Vanessa; Smith, Dan; Drew, Janet; Poggianti, Bianca; Pieri, Mat; Dominquez Palmero, Lillian; Farina, Cecilia

    2016-08-01

    We present the Final Design of the WEAVE next-generation spectroscopy facility for the William Herschel Telescope (WHT), together with a status update on the details of manufacturing, integration and the overall project schedule now that all the major fabrication contracts are in place. We also present a summary of the current planning behind the 5-year initial phase of survey operations. WEAVE will provide optical ground-based follow up of ground-based (LOFAR) and space-based (Gaia) surveys. WEAVE is a multi-object and multi-IFU facility utilizing a new 2-degree prime focus field of view at the WHT, with a buffered pick-and-place positioner system hosting 1000 multi-object (MOS) fibres, 20 integral field units, or a single large IFU for each observation. The fibres are fed to a single (dual-beam) spectrograph, with total of 16k spectral pixels, located within the WHT GHRIL enclosure on the telescope Nasmyth platform, supporting observations at R 5000 over the full 370-1000nm wavelength range in a single exposure, or a high resolution mode with limited coverage in each arm at R 20000. The project is now in the manufacturing and integration phase with first light expected for early of 2018.

  17. Grid connected integrated community energy system. Phase II: final state 2 report. Preliminary design waste management and institutional analysis

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-22

    The Preliminary Design of a Regional, Centralized Solid Waste Management System for the Twin Cities Metropolitan Region in Minnesota is presented. The concept has been developed for the sound environmental and safe disposal of solid waste generated from its health care industry, although some additional waste supplements are included as economic assistance in order to approach a competitive alternative to current health care solid waste disposal costs. The system design focuses on a 132 tons per day high-temperature, slagging pyrolysis system manufactured by Andco Incorporated, Andco-Torrax Division Design criteria are given. A Collection and Transportation System (CTS) has been planned for the movements of solid waste (General and Special) from the generating HHC facilities within a 10-mile waste-shed zone, for municipal solid waste from a local transfer station currently processing municipal solid waste, and for pyrolysis residue to final disposal. Each of these facilities is now considered as service contract operations. Approximately 15 vehicle trips per day are estimated as vehicle traffic delivering the refuse to the pyrolysis facility. Cost estimates for the CTS have been determined in conjunction with current municipal refuse haulers in the TCMR, and valued at the following: HHC General Solid Waste (HHC/GSW) at 6.00 $/T; HHC Special Solid Waste (HHC/SSW) at 20.00 $/T; Municipal Transfer at 4.00 to be paid the pyrolysis system as a drop charge. Special box-bag containers are to be required in handling the HHC/SSW at a cost of 30.19 $/T estimate. The total operating cost for the pyrolysis system has been estimated to be 13.73 $/T, with a steam credit of 11.70 $/T, to yield a net cost of 2.03 $/T. Capital cost has been estimated to be 7,700,800 dollars, 1978. A back-up facility capital investment of $163,000 dollars, 1978 has been estimated, which should be applied to the existing University of Minnesota incinerator.

  18. Final results from the ''investigation of design aspects and design options for wind turbines operating in complex terrain environments'' project

    Energy Technology Data Exchange (ETDEWEB)

    Fragoulis, A.N. [SPA Hellas Engineering S.A., Attiki (Greece); Markkilde, P.S.; Voutsinas, S.; Cuerva, A.; Winkelaar, D.; Ganander, H.

    1999-07-01

    Complex terrain sites are a major and critical market for wind energy development and knowledge regarding the wind structure and the WT response to it is insufficient. The paper presents the work and the final results of the COMTERID project (JOR3-CT95-0033), the successor and the follow-up of MOUNTURB, which was undertaken within the JOULE-III program by a number of National European R and D institutes and universities (CRES, NTUA, CIEMAT, RISO, ECN), consultants, designers and manufacturers (TG, LTL, VESTAS, ECOTECNIA, NWP) with the main objective to identify and quantify the complex terrain environment and its effects in the operation of WTs. The work identified and quantified the complex terrain wind structure conditions which were found to be different from the flat terrain standards and through the development of a parameter identification methodology it identified, evaluated and quantified the machine's performance sensitivity to the Wind-WT parameters. Increased turbulence was found in the vertical and lateral directions on all complex terrain sites studied and smaller length scales compared to the flat terrain standards. These parameters along with the difference in coherence and the small Weibull shape factors encountered (less than 2) are responsible for the increased fatigue loading that WTs experience at complex terrain environments. The project results indicate directions for new machine concepts, specifically for complex terrain operation, that will be both technically and economically efficient. (author)

  19. 77 FR 50936 - Approval and Promulgation of Air Quality Implementation Plans; Nevada; Regional Haze State and...

    Science.gov (United States)

    2012-08-23

    ... San Juan Generating Station in New Mexico. Response 1: It is important to note that EPA is approving... EPA, 2012 U.S. App. LEXIS 1056 (9th Cir. January 19, 2012). Therefore, we are finalizing our approval...

  20. Solar production of intermediate temperature process heat. Phase I design. Final report. [For sugarcane processing plant in Hawaii

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-08-01

    This report is the final effort in the Phase I design of a solar industrial process heat system for the Hilo Coast Processing Company (HCPC) in Pepeekeo, Hawaii. The facility is used to wash, grind and extract sugar from the locally grown sugarcane and it operates 24 hours a day, 305 days per year. The major steam requirements in the industrial process are for the prime movers (mill turbines) in the milling process and heat for evaporating water from the extracted juices. Bagasse (the fibrous residue of milled sugarcane) supplied 84% of the fuel requirement for steam generation in 1979, while 65,000 barrels of No. 6 industrial fuel oil made up the remaining 16%. These fuels are burned in the power plant complex which produces 825/sup 0/F, 1,250 psi superheated steam to power a turbogenerator set which, in addition to serving the factory, generates from 7 to 16 megawatts of electricity that is exported to the local utility company. Extracted steam from the turbo-generator set supplies the plant's process steam needs. The system consists of 42,420 ft./sup 2/ of parabolic trough, single axis tracking, concentrating solar collectors. The collectors will be oriented in a North-South configuration and will track East-West. A heat transfer fluid (Gulf Synfluid 4cs) will be circulated in a closed loop fashion through the solar collectors and a series of heat exchangers. The inlet and outlet fluid temperatures for the collectors are 370/sup 0/F and 450/sup 0/F respectively. It is estimated that the net useable energy delivered to the industrial process will be 7.2 x 10/sup 9/ Btu's per year. With an HCPC boiler efficiency of 78% and 6.2 x 10/sup 6/ Btu's per barrel of oil, the solar energy system will displace 1489 barrels of oil per year. (WHK)

  1. Remedial Action Plan and site design for stabilization of the inactive uranium mill tailings site at Mexican Hat, Utah: Appendix D. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1988-07-01

    This appendix is an assessment of the present conditions of the inactive uranium mill site near Mexican Hat, Utah. It consolidates available engineering, radiological, geotechnical, hydrological, meteorological, and other information pertinent to the design of the Remedial Action Plan. Plan is to characterize the conditions at the mill and tailings site so that the Remedial Action Contractor may complete final designs of the remedial action.

  2. Drugs Approved for Hodgkin Lymphoma

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Hodgkin Lymphoma This page lists cancer drugs approved by ... that are not listed here. Drugs Approved for Hodgkin Lymphoma Adcetris (Brentuximab Vedotin) Ambochlorin (Chlorambucil) Amboclorin (Chlorambucil) ...

  3. Drugs Approved for Lung Cancer

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Lung Cancer This page lists cancer drugs approved by the ... listed here. Drugs Approved for Non-Small Cell Lung Cancer Abitrexate (Methotrexate) Abraxane (Paclitaxel Albumin-stabilized Nanoparticle Formulation) ...

  4. Drugs Approved for Thyroid Cancer

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Thyroid Cancer This page lists cancer drugs approved by the ... that are not listed here. Drugs Approved for Thyroid Cancer Cabozantinib-S-Malate Caprelsa (Vandetanib) Cometriq (Cabozantinib-S-Malate) Doxorubicin ...

  5. Obtained effect size as a function of sample size in approved antidepressants: a real-world illustration in support of better trial design.

    Science.gov (United States)

    Gibertini, Michael; Nations, Kari R; Whitaker, John A

    2012-03-01

    The high failure rate of antidepressant trials has spurred exploration of the factors that affect trial sensitivity. In the current analysis, Food and Drug Administration antidepressant drug registration trial data compiled by Turner et al. is extended to include the most recently approved antidepressants. The expanded dataset is examined to further establish the likely population effect size (ES) for monoaminergic antidepressants and to demonstrate the relationship between observed ES and sample size in trials on compounds with proven efficacy. Results indicate that the overall underlying ES for antidepressants is approximately 0.30, and that the variability in observed ES across trials is related to the sample size of the trial. The current data provide a unique real-world illustration of an often underappreciated statistical truism: that small N trials are more likely to mislead than to inform, and that by aligning sample size to the population ES, risks of both erroneously high and low effects are minimized. The results in the current study make this abstract concept concrete and will help drug developers arrive at informed gate decisions with greater confidence and fewer risks, improving the odds of success for future antidepressant trials.

  6. Remedial action plan and site conceptual design for stabilization of the inactive uranium mill tailings sites at Rifle, Colorado. Appendix D, Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-02-01

    This appendix assesses the present conditions and data gathered about the two designated inactive uranium mill tailings sites near Rifle, Colorado, and the proposed disposal site six miles north of Rifle in the area of Estes Gulch. It consolidates available engineering, radiological, geotechnical, hydrological, meteorological, and other information pertinent to the design of the Remedial Action Plan (RAP). The data characterize conditions at the mill, tailings, and disposal site so that the Remedial Action Contractor (RAC) may complete final designs for the remedial actions.

  7. Conceptual design of advanced central receiver power systems sodium-cooled receiver concept. Volume 2, Book 2. Appendices. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-03-01

    The appendices include: (A) design data sheets and P and I drawing for 100-MWe commercial plant design, for all-sodium storage concept; (B) design data sheets and P and I drawing for 100-MWe commercial plant design, for air-rock bed storage concept; (C) electric power generating water-steam system P and I drawing and equipment list, 100-MWe commercial plant design; (D) design data sheets and P and I drawing for 281-MWe commercial plant design; (E) steam generator system conceptual design; (F) heat losses from solar receiver surface; (G) heat transfer and pressure drop for rock bed thermal storage; (H) a comparison of alternative ways of recovering the hydraulic head from the advanced solar receiver tower; (I) central receiver tower study; (J) a comparison of mechanical and electromagnetic sodium pumps; (K) pipe routing study of sodium downcomer; and (L) sodium-cooled advanced central receiver system simulation model. (WHK)

  8. FWS Approved Acquisition Boundaries

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the external boundaries of lands and waters that are approved for acquisition by the U.S. Fish and Wildlife Service (USFWS) in North America,...

  9. FWS Approved Acquisition Boundaries

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the external boundaries of lands and waters that are approved for acquisition by the U.S. Fish and Wildlife Service (USFWS) in North...

  10. FWS Approved Acquisition Boundaries

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This data layer depicts the external boundaries of lands and waters that are approved for acquisition by the U.S. Fish and Wildlife Service (USFWS) in North America,...

  11. Drugs Approved for Leukemia

    Science.gov (United States)

    This page lists cancer drugs approved by the FDA for use in leukemia. The drug names link to NCI's Cancer Drug Information summaries. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters.

  12. Drugs Approved for Retinoblastoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for retinoblastoma. The list includes generic names and brand names. The drug names link to NCI’s Cancer Drug Information summaries.

  13. Drugs Approved for Neuroblastoma

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for neuroblastoma. The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  14. Premarket Approvals (PMA)

    Data.gov (United States)

    U.S. Department of Health & Human Services — Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An...

  15. Premarket Approvals (PMA)

    Data.gov (United States)

    U.S. Department of Health & Human Services — Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An...

  16. Dental devices: classification of dental amalgam, reclassification of dental mercury, designation of special controls for dental amalgam, mercury, and amalgam alloy; technical amendment. Final rule; technical amendment.

    Science.gov (United States)

    2010-06-11

    The Food and Drug Administration (FDA) published a final rule in the Federal Register of August 4, 2009 (74 FR 38686) which classified dental amalgam as a class II device, reclassified dental mercury from class I to class II, and designated special controls for dental amalgam, mercury, and amalgam alloy. The effective date of the rule was November 2, 2009. The final rule was published with an inadvertent error in the codified section. This document corrects that error. This action is being taken to ensure the accuracy of the agency's regulations.

  17. New Concepts in Fish Ladder Design, Part I of IV, Summary Report, 1982-1984 Final Project Report.

    Energy Technology Data Exchange (ETDEWEB)

    Orsborn, John F.

    1985-08-01

    The report looks at the most active periods of fishway research since 1938 as background for a project to apply fundamental fluid and bio-mechanics to fishway design, and develop more cost effective fish passage facilities with primary application to small scale hydropower facilities. Also discussed are new concepts in fishway design, an assessment of fishway development and design, and an analysis of barriers to upstream migration. (ACR)

  18. Ocean thermal energy conversion power system development-I. Phase I. Preliminary design report. Volume 1. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-18

    The results of a conceptual and preliminary design study of Ocean Thermal Energy Conversion (OTEC) closed loop ammonia power system modules performed by Lockheed Missiles and Space Company, Inc. (LMSC) are presented. This design study is the second of 3 tasks in Phase I of the Power System Development-I Project. The Task 2 objectives were to develop: 1) conceptual designs for a 40 to 50-MW(e) closed cycle ammonia commercial plant size power module whose heat exchangers are immersed in seawater and whose ancillary equipments are in a shirt sleeve environment; preliminary designs for a modular application power system sized at 10-MW(e) whose design, construction and material selection is analogous to the 50 MW(e) module, except that titanium tubes are to be used in the heat exchangers; and 3) preliminary designs for heat exchanger test articles (evaporator and condenser) representative of the 50-MW(e) heat exchangers using aluminum alloy, suitable for seawater service, for testing on OTEC-1. The reference ocean platform was specified by DOE as a surface vessel with the heat exchanger immersed in seawater to a design depth of 0 to 20 ft measured from the top of the heat exchanger. For the 50-MW(e) module, the OTEC 400-MW(e) Plant Ship, defined in the Platform Configuration and Integration study, was used as the reference platform. System design, performance, and cost are presented. (WHK)

  19. Human-system interface design review guideline -- Reviewer`s checklist: Final report. Revision 1, Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    NUREG-0700, Revision 1, provides human factors engineering (HFE) guidance to the US Nuclear Regulatory Commission staff for its: (1) review of the human system interface (HSI) design submittals prepared by licensees or applications for a license or design certification of commercial nuclear power plants, and (2) performance of HSI reviews that could be undertaken as part of an inspection or other type of regulatory review involving HSI design or incidents involving human performance. The guidance consists of a review process and HFE guidelines. The document describes those aspects of the HSI design review process that are important to the identification and resolution of human engineering discrepancies that could adversely affect plant safety. Guidance is provided that could be used by the staff to review an applicant`s HSI design review process or to guide the development of an HSI design review plan, e.g., as part of an inspection activity. The document also provides detailed HFE guidelines for the assessment of HSI design implementations. NUREG-0700, Revision 1, consists of three stand-alone volumes. Volume 2 is a complete set of the guidelines contained in Volume 1, Part 2, but in a checklist format that can be used by reviewers to assemble sets of individual guidelines for use in specific design reviews. The checklist provides space for reviewers to enter guidelines evaluations and comments.

  20. SOLERAS - Solar Controlled Environment Agriculture Project. Final report, Volume 4. Saudi Engineering Solar Energy Applications System Design Study

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    Literature summarizing a study on the Saudi Arabian solar controlled environment agriculture system is presented. Specifications and performance requirements for the system components are revealed. Detailed performance and cost analyses are used to determine the optimum design. A preliminary design of an engineering field test is included. Some weather data are provided for Riyadh, Saudi Arabia. (BCS)

  1. 76 FR 62635 - Approval and Promulgation of Air Quality Implementation Plans; Commonwealth of Virginia; Section...

    Science.gov (United States)

    2011-10-11

    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; Commonwealth of... (EPA). ACTION: Final rule. SUMMARY: EPA is approving submittals from the Commonwealth of Virginia... published a notice of proposed rulemaking (NPR) for the Commonwealth of Virginia. The NPR proposed approval...

  2. High Falls generation station expansion approvals process

    Energy Technology Data Exchange (ETDEWEB)

    Litschko, C. [Lakeland Holding, Bracebridge, ON (Canada)

    2005-07-01

    Lakeland Holding Ltd. is the parent company for Lakeland Power Distribution Ltd., Bracebridge Generation Ltd., and Lakeland Energy Ltd. This PowerPoint presentation highlighted the High Falls generation expansion process. During construction of the High Falls plant, a concrete foundation was built beside the plant for future expansion. The expansion process involves building a 1,500 kilowatt generator to supply electricity to as many as 1600 households. The presentation described the context and background for the expansion and presented information on the water power generation plants. It presented site specifications as well as the approvals process by which final approval was granted in 2004. Observations and lessons learned from the approval process were identified. figs.

  3. Joint application of AI techniques, PRA and disturbance analysis methodology to problems in the maintenance and design of nuclear power plants. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Okrent, D.

    1989-03-01

    This final report summarizes the accomplishments of a two year research project entitled ``Joint Application of Artificial Intelligence Techniques, Probabilistic Risk Analysis, and Disturbance Analysis Methodology to Problems in the Maintenance and Design of Nuclear Power Plants. The objective of this project is to develop and apply appropriate combinations of techniques from artificial intelligence, (AI), reliability and risk analysis and disturbance analysis to well-defined programmatic problems of nuclear power plants. Reactor operations issues were added to those of design and maintenance as the project progressed.

  4. Understanding of Student Task Interpretation, Design Planning, and Cognitive Strategies during Engineering Design Activities in Grades 9-12. Final Report. Research in Engineering and Technology Education

    Science.gov (United States)

    Lawanto, Oenardi

    2011-01-01

    The objective of this study was to describe the task interpretation of students engaged in a design activity and determine the extent to which students translate their understanding of their design task to their planning and cognitive strategies. Twenty-nine students at one Colorado high school participated in this study. Students worked…

  5. Final Report: Rational Design of Anode Surface Chemistry in Microbial Fuel Cells for Improved Exoelectrogen Attachment and Electron Transfer

    Science.gov (United States)

    2015-12-21

    surface of Shewanella oneidnesis. Using the same set of conjugated gold nanoparticles we employ (conjugations include amine, methyl and carboxylic...than platinum (Pt) during screening in “clean” conditions (PBS) (Figure 12), and no degradation in performance during the operation in wastewater...Figure 13. Voltage trend of MFCs over 16 days period of Fe-AAPyr (black), Pt ( blue ) and AC (red) cathode catalysts. Final report W911NF-12

  6. Pembrolizumab: first global approval.

    Science.gov (United States)

    Poole, Raewyn M

    2014-10-01

    Pembrolizumab [Keytruda(®) (US)], a humanized monoclonal antibody against the programmed death receptor-1 (PD-1) protein, has been developed by Merck & Co for the treatment of cancer. Pembrolizumab has received its first global approval for the treatment of advanced, unresectable or metastatic malignant melanoma in the US, for use in patients with disease progression after prior treatment with ipilimumab and, for BRAF V600 mutation-positive patients, a BRAF inhibitor. It is the first anti-PD-1 therapy to receive regulatory approval in the US, and is currently under regulatory review in the EU. This article summarizes the milestones in the development of pembrolizumab leading to this first approval for the treatment of malignant melanoma.

  7. Pomalidomide: first global approval.

    Science.gov (United States)

    Elkinson, Shelley; McCormack, Paul L

    2013-05-01

    Pomalidomide (Pomalyst(®)) is a small molecule analogue of thalidomide under development with Celgene Corporation for the oral treatment of haematological and connective tissue diseases. Pomalidomide has been approved in the USA and is awaiting approval in the EU for use with low-dose dexamethasone for the treatment of relapsed and refractory multiple myeloma that has progressed following at least two prior therapies, including lenalidomide and bortezomib. The efficacy and safety of pomalidomide as monotherapy in patients with relapsed and refractory multiple myeloma has also been evaluated in a phase III trial. The agent is in phase III clinical development for the treatment of myelofibrosis and in phase II development for systemic sclerosis. Pomalidomide is also being investigated in patients with amyloidosis, prostate cancer, small cell lung cancer, pancreatic cancer, graft-versus-host disease, and Waldenstrom's macroglobulinaemia. This article summarizes the milestones in the development of pomalidomide leading to this first global approval for relapsed and refractory multiple myeloma.

  8. Apremilast: first global approval.

    Science.gov (United States)

    Poole, Raewyn M; Ballantyne, Anita D

    2014-05-01

    Apremilast (Otezla(®)), an oral small molecule inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4), is under development with Celgene Corporation for the treatment of psoriatic arthritis, psoriasis, ankylosing spondylitis, Behçet's syndrome, atopic dermatitis, and rheumatoid arthritis. Apremilast is indicated for the treatment of active psoriatic arthritis in adults. Apremilast has received its first global approval for this indication in the USA. Regulatory submissions for approval in this indication are under review in Canada and Europe. Regulatory filings have also been submitted for apremilast in the treatment of plaque psoriasis in the USA and Europe. This article summarizes the milestones in the development of apremilast leading to its first approval for the treatment of psoriatic arthritis.

  9. Dynamic Isotope Power System (DIPS) Applications Study. Volume II. Nuclear Integrated Multimission Spacecraft (NIMS) design definition. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Prickett, W. Z.

    1979-11-01

    The design requirements for the Nuclear Integrated Multimission Spacecraft. (NIMS) are discussed in detail. The requirements are a function of mission specifications, payload, control system requirements, electric system specifications, and cost limitations. (LCL)

  10. Uranium Mill Tailings Remedial Action Project (UMTRAP), Slick Rock, Colorado, Revision 1. Volume 1, Calculations, Final design for construction

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    Volume one contains calculations for: embankment design--embankment material properties; Union Carbide site--bedrock contours; vicinity properties--origin of contamination; North Continent and Union Carbide sites contaminated materials--excavation quantities; and demolition debris--quantity estimate.

  11. EPA Finalizes Initial Area Designations for the 2012 National Air Quality Standard for Fine Particles - Dec 2014

    Science.gov (United States)

    After considering state and tribal recommendations, reviewing the most recent certified fine particle air quality data, and emissions that contribute fine particle pollution, EPA has completed initial designations for the 2012 annual fine particle standard

  12. Conceptual design of retrieval systems for emplaced transuranic waste containers in a salt bed depository. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Fogleman, S.F.

    1980-04-01

    The US Department of Energy and the Nuclear Regulatory Commission have jurisdiction over the nuclear waste management program. Design studies were previously made of proposed repository site configurations for the receiving, processing, and storage of nuclear wastes. However, these studies did not provide operational designs that were suitable for highly reliable TRU retrieval in the deep geologic salt environment for the required 60-year period. The purpose of this report is to develop a conceptual design of a baseline retrieval system for emplaced transuranic waste containers in a salt bed depository. The conceptual design is to serve as a working model for the analysis of the performance available from the current state-of-the-art equipment and systems. Suggested regulations would be based upon the results of the performance analyses.

  13. Near Term Hybrid Passenger Vehicle Development Program. Phase I, Final report. Appendix C: preliminary design data package. Volume I

    Energy Technology Data Exchange (ETDEWEB)

    Piccolo, R.

    1979-07-31

    The assumptions made, analysis methods used, and preliminary results of research to determine the design specifications for a hybrid electric-powered and internal combustion engine-powered vehicle that would optimize the fuel economy of passenger automobiles are described. Information is included on body and component design, selection of spark-ignition engine and Ni-Zn batteries, life-cycle costs and life-cycle fuel consumption. (LCL)

  14. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    R Paul Drake

    2004-01-12

    OAK-B135 This is the final report from the project Hydrodynamics by High-Energy-Density Plasma Flow and Hydrodynamics and Radiation Hydrodynamics with Astrophysical Applications. This project supported a group at the University of Michigan in the invention, design, performance, and analysis of experiments using high-energy-density research facilities. The experiments explored compressible nonlinear hydrodynamics, in particular at decelerating interfaces, and the radiation hydrodynamics of strong shock waves. It has application to supernovae, astrophysical jets, shock-cloud interactions, and radiative shock waves.

  15. Valve inlet fluid conditions for pressurizer safety and relief valves in Westinghouse-designed plants. Final report. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Meliksetian, A.; Sklencar, A.M.

    1982-12-01

    The overpressure transients for Westinghouse-designed NSSSs are reviewed to determine the fluid conditions at the inlet to the PORV and safety valves. The transients considered are: licensing (FSAR) transients; extended operation of high pressure safety injection system; and cold overpressurization. The results of this review, presented in the form of tables and graphs, define the range of fluid conditions expected at the inlet to pressurized safety and power-operated relief valves utilized in Westinghouse-designed PWR units. These results will provide input to the PWR utilities in their justification that the fluid conditions under which their valve designs were tested as part of the EPRI/PWR Safety and Relief Valve Test Program indeed envelop those expected in their units.

  16. Georgetown University Integrated Community Energy System (GU-ICES). Phase III, Stage II. Preliminary design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-11-01

    Results are presented for two elements in the Georgetown University ICES program - the installation of a 2500-kW backpressure steam-turbine generator within a new extension to the heating and cooling plant (cogeneration) and the provision of four additional ash silos for the university's atmospheric fluidized-bed boiler plant (added storage scheme). The preliminary design and supporting documentation for the work items and architectural drawings are presented. Section 1 discusses the basis for the report, followed by sections on: feasibility analysis update; preliminary design documents; instrumentation and testing; revised work management plan; and appendices including outline constructions, turbine-generator prepurchase specification, design calculations, cost estimates, and Potomac Electric Company data. (MCW)

  17. Fort Hood Solar Total Energy Project. Volume II. Preliminary design. Part 2. System performance and supporting studies. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1979-01-01

    The preliminary design developed for the Solar Total Energy System to be installed at Fort Hood, Texas, is presented. System performance analysis and evaluation are described. Feedback of completed performance analyses on current system design and operating philosophy is discussed. The basic computer simulation techniques and assumptions are described and the resulting energy displacement analysis is presented. Supporting technical studies are presented. These include health and safety and reliability assessments; solar collector component evaluation; weather analysis; and a review of selected trade studies which address significant design alternatives. Additional supporting studies which are generally specific to the installation site are reported. These include solar availability analysis; energy load measurements; environmental impact assessment; life cycle cost and economic analysis; heat transfer fluid testing; meteorological/solar station planning; and information dissemination. (WHK)

  18. Application analysis of solar total energy systems to the residential sector. Volume III, conceptual design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-07-01

    The objective of the work described in this volume was to conceptualize suitable designs for solar total energy systems for the following residential market segments: single-family detached homes, single-family attached units (townhouses), low-rise apartments, and high-rise apartments. Conceptual designs for the total energy systems are based on parabolic trough collectors in conjunction with a 100 kWe organic Rankine cycle heat engine or a flat-plate, water-cooled photovoltaic array. The ORC-based systems are designed to operate as either independent (stand alone) systems that burn fossil fuel for backup electricity or as systems that purchase electricity from a utility grid for electrical backup. The ORC designs are classified as (1) a high temperature system designed to operate at 600/sup 0/F and (2) a low temperature system designed to operate at 300/sup 0/F. The 600/sup 0/F ORC system that purchases grid electricity as backup utilizes the thermal tracking principle and the 300/sup 0/F ORC system tracks the combined thermal and electrical loads. Reject heat from the condenser supplies thermal energy for heating and cooling. All of the ORC systems utilize fossil fuel boilers to supply backup thermal energy to both the primary (electrical generating) cycle and the secondary (thermal) cycle. Space heating is supplied by a central hot water (hydronic) system and a central absorption chiller supplies the space cooling loads. A central hot water system supplies domestic hot water. The photovoltaic system uses a central electrical vapor compression air conditioning system for space cooling, with space heating and domestic hot water provided by reject heat from the water-cooled array. All of the systems incorporate low temperature thermal storage (based on water as the storage medium) and lead--acid battery storage for electricity; in addition, the 600/sup 0/F ORC system uses a therminol-rock high temperature storage for the primary cycle. (WHK)

  19. 28 CFR 48.15 - Temporary approval.

    Science.gov (United States)

    2010-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) NEWSPAPER PRESERVATION ACT § 48.15 Temporary... temporary approval may do so by delivering a statement of protest or telephoning his views to an employee of the Department of Justice, whose name, address and telephone number shall be designated by...

  20. Approved Practices in Dairy Reproduction. Slide Script.

    Science.gov (United States)

    Roediger, Roger D.; Barr, Harry L.

    This slide script, part of a series of slide scripts designed for use in vocational agriculture classes, deals with approved practices in dairy reproduction. Included in the guide are narrations for use with 200 slides dealing with the following topics: the importance of good reproduction, the male and female roles in reproduction, selection of…

  1. Design and development of an automotive propulsion system utilizing a Rankine cycle engine (water based fluid). Final report

    Energy Technology Data Exchange (ETDEWEB)

    Demler, R.L.

    1977-09-01

    Under EPA and ERDA sponsorship, SES successfully designed, fabricated and tested the first federally sponsored steam powered automobile. The automobile - referred to as the simulator - is a 1975 Dodge Monaco standard size passenger car with the SES preprototype Rankine cycle automotive propulsion system mounted in the engine compartment. In the latter half of 1975, the simulator successfully underwent test operations at the facilities of SES in Watertown, Massachusetts and demonstrated emission levels below those of the stringent federally established automotive requirements originally set for implementation by 1976. The demonstration was accomplished during testing over the Federal Driving Cycle on a Clayton chassis dynamometer. The design and performance of the vehicle are described.

  2. Role of design complexity in forecasting reliability and availability for electric-power-generating units. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Berkey, D.M.; Balaban, H.S.

    1982-10-01

    This report examines the relationship between design complexity and reliability and availability performance for fossil-fueled electric-power-generating units. Multivariate regression analysis was applied to design complexity and reliability and availability performance data gathered from a representative sample of electric-power-generating units. Twelve predictive relationships or equations were developed as a result of employing this statistical procedure. Each equation was verified and assessed. Guidelines for applying the predictive relationships, including confidence limits, were also developed and are presented in this report. A major result of this examination is a quantitative predictive tool that should be useful to the electric-power industry.

  3. Saccharomyces cerevisiae single-copy plasmids for auxotrophy compensation, multiple marker selection, and for designing metabolically cooperating communities [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Michael Mülleder

    2016-09-01

    Full Text Available Auxotrophic markers are useful tools in cloning and genome editing, enable a large spectrum of genetic techniques, as well as facilitate the study of metabolite exchange interactions in microbial communities. If unused background auxotrophies are left uncomplemented however, yeast cells need to be grown in nutrient supplemented or rich growth media compositions, which precludes the analysis of biosynthetic metabolism, and which leads to a profound impact on physiology and gene expression. Here we present a series of 23 centromeric plasmids designed to restore prototrophy in typical Saccharomyces cerevisiae laboratory strains. The 23 single-copy plasmids complement for deficiencies in HIS3, LEU2, URA3, MET17 or LYS2 genes and in their combinations, to match the auxotrophic background of the popular functional-genomic yeast libraries that are based on the S288c strain. The plasmids are further suitable for designing self-establishing metabolically cooperating (SeMeCo communities, and possess a uniform multiple cloning site to exploit multiple parallel selection markers in protein expression experiments.

  4. A CRISPR/Cas9-based method and primer design tool for seamless genome editing in fission yeast [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    María Rodríguez-López

    2017-01-01

    Full Text Available In the fission yeast Schizosaccharomyces pombe the prevailing approach for gene manipulations is based on homologous recombination of a PCR product that contains genomic target sequences and a selectable marker. The CRISPR/Cas9 system has recently been implemented in fission yeast, which allows for seamless genome editing without integration of a selection marker or leaving any other genomic ‘scars’. The published method involves manual design of the single guide RNA (sgRNA, and digestion of a large plasmid with a problematic restriction enzyme to clone the sgRNA. To increase the efficiency of this approach, we have established and optimized a PCR-based system to clone the sgRNA without restriction enzymes into a plasmid with a dominant natMX6 (nourseothricin selection marker. We also provide a web-tool, CRISPR4P, to support the design of the sgRNAs and the primers required for the entire process of seamless DNA deletion. Moreover, we report the preparation of G1-synchronized and cryopreserved S. pombe cells, which greatly increases the efficiency and speed for transformations, and may also facilitate standard gene manipulations. Applying this optimized CRISPR/Cas9-based approach, we have successfully deleted over 80 different non-coding RNA genes, which are generally lowly expressed, and have inserted 7 point mutations in 4 different genomic regions.

  5. A CRISPR/Cas9-based method and primer design tool for seamless genome editing in fission yeast [version 3; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    María Rodríguez-López

    2017-05-01

    Full Text Available In the fission yeast Schizosaccharomyces pombe the prevailing approach for gene manipulations is based on homologous recombination of a PCR product that contains genomic target sequences and a selectable marker. The CRISPR/Cas9 system has recently been implemented in fission yeast, which allows for seamless genome editing without integration of a selection marker or leaving any other genomic ‘scars’. The published method involves manual design of the single guide RNA (sgRNA, and digestion of a large plasmid with a problematic restriction enzyme to clone the sgRNA. To increase the efficiency of this approach, we have established and optimized a PCR-based system to clone the sgRNA without restriction enzymes into a plasmid with a dominant natMX6 (nourseothricin selection marker. We also provide a web-tool, CRISPR4P, to support the design of the sgRNAs and the primers required for the entire process of seamless DNA deletion. Moreover, we report the preparation of G1-synchronized and cryopreserved S. pombe cells, which greatly increases the efficiency and speed for transformations, and may also facilitate standard gene manipulations. Applying this optimized CRISPR/Cas9-based approach, we have successfully deleted over 80 different non-coding RNA genes, which are generally lowly expressed, and have inserted 7 point mutations in 4 different genomic regions.

  6. An adaptable toolkit to assess commercial fishery costs and benefits related to marine protected area network design [version 2; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Rémi M. Daigle

    2017-02-01

    Full Text Available Around the world, governments are establishing Marine Protected Area (MPA networks to meet their commitments to the United Nations Convention on Biological Diversity. MPAs are often used in an effort to conserve biodiversity and manage fisheries stocks. However, their efficacy and effect on fisheries yields remain unclear. We conducted a case-study on the economic impact of different MPA network design strategies on the Atlantic cod (Gadus morhua fisheries in Canada. The open-source R package that we developed to analyze this case study can be customized to conduct similar analyses for other systems. We used a spatially-explicit individual-based model of population growth and dispersal coupled with a fisheries management and harvesting component. We found that MPA networks that both protect the target species’ habitat and were spatially optimized to improve population connectivity had the highest net present value (i.e., were most profitable for the fishing industry. These higher profits were achieved primarily by reducing the distance travelled for fishing and reducing the probability of a moratorium event. These findings add to a growing body of knowledge demonstrating the importance of incorporating population connectivity in the MPA planning process, as well as the ability of this R package to explore ecological and economic consequences of alternative MPA network designs.

  7. Heartland Winthrop Approval

    Science.gov (United States)

    This May 19, 2016 letter from EPA approves the petition from Heartland Corn Products regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS program.

  8. Poet Lake Crystal Approval

    Science.gov (United States)

    This September 19, 2016 letter from EPA approves the petition from Poet Biorefining-Lake Crystal, regarding non-grandfathered ethanol produced through a dry mill process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the RFS

  9. FDA Approval for Imiquimod

    Science.gov (United States)

    On July 15, 2004, the U.S. Food and Drug Administration (FDA) announced the approval of a new indication for Aldara® (imiquimod) topical cream for the treatment of superficial basal cell carcinoma (sBCC), a type of skin cancer.

  10. FHR Iowa Falls Approval

    Science.gov (United States)

    This October 22, 2015, letter from EPA approves the petition from Flint Hills Resources, LLC, regarding non-grandfathered ethanol produced through the FHR Iowa Falls Process, qualifying under the Clean Air Act for renewable fuel (D-code 6) RINs under the R

  11. Detailed conceptual design of a high temperature CO/sub 2/ sensor for geothermal brine. Final report, Task II

    Energy Technology Data Exchange (ETDEWEB)

    Phelan, D.M.; Taylor, R.M.; Kugler, G.C.

    1985-10-01

    The Task I pCO/sub 2/ sensor was evaluated in the laboratory and improvements incorporated. Of special note was the redesign of the internal reference electrode which offered greater stability, and improved reliability - a design both smaller and more simple. The ISFET sensor was improved by using a new sensing material which afforded better speed of response. The H/sub 2/S getter was redesigned to overcome seal problems encountered in early Task II tests. The improved probe was thoroughly tested in the laboratory at both moderate and elevated temperatures. This version was also tested at the Magma Electric Company geothermal plant in California. Whereas the laboratory tests were encouraging, the field tests were disappointing, in part due to problems not directly attributable to probe design limitations. In both tests, however, evidence showed that the polymeric seal in the internal ISFET element limited probe life unacceptably in the hot aqueous environment. Electrostatic bonding of silicon to glass for three critical seals is included in the Task II recommended design. All elements of the design were tested successfully in the laboratory.

  12. Grid connected integrated community energy system. Phase II: final stage 2 report. Preliminary design of cogeneration plant

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-22

    The preliminary design of a dual-purpose power plant to be located on the University of Minnesota is described. This coal-fired plant will produce steam and electric power for a grid-connected Integrated Community Energy System. (LCL)

  13. Design for the Assessment and Policy Analysis of the Education Satellite Communications Demonstration. Phase 2 Final Report.

    Science.gov (United States)

    Syracuse Univ. Research Corp., NY. Educational Policy Research Center.

    The overall goal of the Education Satellite Communications Demonstration is to design a framework for the analysis of the potential utility of satellites to education in this country. Within this framework, Phase 2 sought to identify research which would be clearly related to educational goals that might be worthy of attainment. The entire…

  14. FY05 LDRD Final Report A Computational Design Tool for Microdevices and Components in Pathogen Detection Systems

    Energy Technology Data Exchange (ETDEWEB)

    Trebotich, D

    2006-02-07

    We have developed new algorithms to model complex biological flows in integrated biodetection microdevice components. The proposed work is important because the design strategy for the next-generation Autonomous Pathogen Detection System at LLNL is the microfluidic-based Biobriefcase, being developed under the Chemical and Biological Countermeasures Program in the Homeland Security Organization. This miniaturization strategy introduces a new flow regime to systems where biological flow is already complex and not well understood. Also, design and fabrication of MEMS devices is time-consuming and costly due to the current trial-and-error approach. Furthermore, existing devices, in general, are not optimized. There are several MEMS CAD capabilities currently available, but their computational fluid dynamics modeling capabilities are rudimentary at best. Therefore, we proposed a collaboration to develop computational tools at LLNL which will (1) provide critical understanding of the fundamental flow physics involved in bioMEMS devices, (2) shorten the design and fabrication process, and thus reduce costs, (3) optimize current prototypes and (4) provide a prediction capability for the design of new, more advanced microfluidic systems. Computational expertise was provided by Comp-CASC and UC Davis-DAS. The simulation work was supported by key experiments for guidance and validation at UC Berkeley-BioE.

  15. Instructor/Operator Station Design Handbook for Aircrew Training Devices. Final Technical Report for Period March 1982-December 1986.

    Science.gov (United States)

    Warner, H. D.

    Human engineering guidelines for the design of instructor/operator stations (IOSs) for aircrew training devices are provided in this handbook. These guidelines specify the preferred configuration of IOS equipment across the range of the anticipated user sizes and performance capabilities. The guidelines are consolidated from various human…

  16. Consultancy on Large-Scale Submerged Aerobic Cultivation Process Design - Final Technical Report: February 1, 2016 -- June 30, 2016

    Energy Technology Data Exchange (ETDEWEB)

    Crater, Jason [Gemomatica, Inc., San Diego, CA (United States); Galleher, Connor [Gemomatica, Inc., San Diego, CA (United States); Lievense, Jeff [Gemomatica, Inc., San Diego, CA (United States)

    2017-05-12

    NREL is developing an advanced aerobic bubble column model using Aspen Custom Modeler (ACM). The objective of this work is to integrate the new fermentor model with existing techno-economic models in Aspen Plus and Excel to establish a new methodology for guiding process design. To assist this effort, NREL has contracted Genomatica to critique and make recommendations for improving NREL's bioreactor model and large scale aerobic bioreactor design for biologically producing lipids at commercial scale. Genomatica has highlighted a few areas for improving the functionality and effectiveness of the model. Genomatica recommends using a compartment model approach with an integrated black-box kinetic model of the production microbe. We also suggest including calculations for stirred tank reactors to extend the models functionality and adaptability for future process designs. Genomatica also suggests making several modifications to NREL's large-scale lipid production process design. The recommended process modifications are based on Genomatica's internal techno-economic assessment experience and are focused primarily on minimizing capital and operating costs. These recommendations include selecting/engineering a thermotolerant yeast strain with lipid excretion; using bubble column fermentors; increasing the size of production fermentors; reducing the number of vessels; employing semi-continuous operation; and recycling cell mass.

  17. Advanced design and economic considerations for commercial geothermal power plants at Heber and Niland, California. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1977-10-01

    Two separate studies, involving advanced design and economic considerations for commercial geothermal power plants using liquid-dominated hydrothermal resources, are presented. In the first study, the effects on design, capital cost, and bus bar electric energy production cost caused by an anticipated decline in available geothermal fluid temperature over the lifetime of power plants are described. A two-stage, flashed-steam energy conversion process was used for the conceptual design of the power plants, which operate from the moderate-temperature, low-salinity reservoir at Heber, California. Plants with net capacities of 50, 100, and 200 MWe (net) were investigated. The results show that it is important to include provision for geothermal fluid temperature decline in the design of power plants to prevent loss of electric energy production capability and to reduce bus bar electric energy costs. In the second study, the technical, economic, and environmental effects of adding regeneration to a 50 MWe (net) power plant employing the multistage-flash/binary process are described. Regeneration is potentially attractive because it recovers waste heat from the turbine exhaust and uses it in the power cycle. However, the pressure drop caused by the introduction of the regenerator decreases the turbine expansion and thus decreases system performance. An innovative approach was taken in the design of the regenerator, which minimized the expected performance degradation of the turbine. The result was that the performance, capital cost, and bus bar electric energy production cost are nearly the same for the processes with and without regeneration. On the other hand, the addition of regeneration has the environmental benefits of substantially reducing heat rejection to the atmosphere and cooling tower makeup and blowdown water requirements. It also increases the temperature of the brine returned to the field for reinjection.

  18. Final disposal of spent nuclear fuel in Sweden. Some unresolved issues and challenges in the design and implementation of the forthcoming planning and EIA processes

    Energy Technology Data Exchange (ETDEWEB)

    Bjarnadottir, H.; Hilding-Rydevik, T. [Nordregio, Stockholm (Sweden)

    2001-06-01

    The aim of the study is to highlight some unresolved and challenging issues in the forthcoming approximately six year long Environmental Impact Assessment (EIA) and planning process of the long-term disposal of spent nuclear fuel in Sweden. Different international and Nordic experiences of the processes for final disposal as well as from other development of similar scope, where experiences assumed to be of importance for final disposal of nuclear waste, have been described. Furthermore, issues relating to 'good EIA practice' as well as certain aspects of planning theory have also been presented. The current Swedish situation for the planning and EIA process of the final disposal of spent nuclear fuel was also been summarized. These different 'knowledge areas' have been compared and measured against our perception of the expectations towards the forthcoming process, put forward by different Swedish actors in the field. The result is a presentation of a number of questions and identification issues that the authors consider need special attention in the design and conduction of the planning and EIA process. The study has been realized through a literature survey and followed by reading and analysis of the written material. The main focus of the literature search was on material describing planning processes, actor perspectives and EIA. Material and literature on the technical and scientific aspects of spent nuclear fuel disposal was however deliberately avoided. There is a wealth of international and Swedish literature concerning final disposal of spent nuclear fuel - concerning both technical issues and issues concerning for example public participation and risk perception. But material of a more systematic and comparative nature (relating to both empirical and theoretical issues, and to practical experiences) in relation to EIA processes and communicative planning for final disposal of spent nuclear fuel seems to be more sparsely represented

  19. Report on the design and operation of a full-scale anaerobic dairy manure digester. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Coppinger, E.; Brautigam, J.; Lenart, J.; Baylon, D.

    1979-12-01

    A full-scale anaerobic digester on the Monroe State Dairy Farm was operated and monitored for 24 months with funding provided by the United States Department of Energy, Fuels from Biomass Systems Branch. During the period of operation, operating parameters were varied and the impact of those changes is described. Operational experiences and system component performance are discussed. Internal digester mixing equipment was found to be unnecessary, and data supporting this conclusion are given. An influent/effluent heat exchanger was installed and tested, and results of the tests are included. Recommendations for digester design and operation are presented. Biological stability was monitored, and test results are given. Gas production rates and system net energy are analyzed. The economics of anaerobic digestion are evaluated based on various financing options, design scales, and expected benefits. Under many circumstances digesters are feasible today, and a means of analysis is given.

  20. Fabrication and Design Testing of 4 Petals for Deployable Starshade Prototype : JPL Summer Internship Program : Final Report

    Science.gov (United States)

    Paxton, Laurel

    2012-01-01

    One of the next steps in the exoplanet search is the development of occulter technology. Starlight suppression for a telescope would provide the ability to more accurately find and characterize potential true-Earth analogs. Coronagraphs have been the subject of much research in recent years but have yet to prove themselves a feasible approach. Attention has now turned to external occulters or starshades. A large occulting mask in front of a telescope should provide a comparable optical resolution to a coronagraph. Under a TDEM grant, a proposed starshade design was demonstrated to exceed coronagraph resolution by at least an order of magnitude. The current project is to demonstrate that the current design can be manufactured and then properly deployed. 4 sample starshade petals were constructed, ready to be attached to a pre-existing deployment truss. Time was spent detailing and modifying the petal construction process, so that future petals could be constructed at a more accurate and faster pace.

  1. Valve inlet fluid conditions for pressurizer safety and relief valves in combustion engineering-designed plants. Final report. [PWR

    Energy Technology Data Exchange (ETDEWEB)

    Bahr, J.; Chari, D.; Puchir, M.; Weismantel, S.

    1982-12-01

    The purpose of this study is to assemble documented information for C-E designed plants concerning pressurizer safety and power operated relief valve (PROV) inlet fluid conditions during actuation as calculated by conventional licensing analyses. This information is to be used to assist in the justification of the valve inlet fluid conditions selected for the testing of safety valves and PORVs in the EPRI/PWR Safety/Relief Valve Test Program. Available FSAR/Reload analyses and certain low temperature overpressurization analyses were reviewed to identify the pressurization transients which would actuate the valves, and the corresponding valve inlet fluid conditions. In addition, consideration was given to the Extended High Pressure Liquid Injection event. A general description of each pressurization transient is provided. The specific fluid conditions identified and tabulated for each C-E designed plant for each transient are peak pressurizer pressure, pressure ramp rate at actuation, temperature and fluid state.

  2. Design of a self-regulating composite bearingless blade wind turbine. Final report, October 15, 1976-August 15, 1977

    Energy Technology Data Exchange (ETDEWEB)

    Spierings, P.A.M.; Cheney, M.C.

    1978-01-01

    A study was undertaken to design a 40-ft diameter wind turbine employing the UTRC/ERDA Self-Regulating Composite Bearingless Rotor (CBR) concept. The CBR concept was developed at United Technologies for rotary wing applications and is now in use on Sikorsky helicopters. The concept was further developed for wind turbine applications at UTRC under an ERDA contract in 1975-76. Successful wind tunnel tests were conducted during that contract, which demonstrated the self-starting and self-regulating features. The latest contract was to design a 40-ft system in the 5 kW - 15 kW power range. This effort included performance tradeoff studies, stress analyses of the blade and tower structure, a stability investigation, and engineering drawings of the complete system. However an overall cost analysis was not performed in this study.

  3. Design, Fabrication, and Operation of Innovative Microalgae Culture Experiments for the Purpose of Producing Fuels: Final Report, Phase I

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    A conceptual design was developed for a 1000-acre (water surface) algae culture facility for the production of fuels. The system is modeled after the shallow raceway system with mixing foils that is now being operated at the University of Hawaii. A computer economic model was created to calculate the discounted breakeven price of algae or fuels produced by the culture facility. A sensitivity analysis was done to estimate the impact of changes in important biological, engineering, and financial parameters on product price.

  4. Design, fabrication and testing of a marketable waterwall component. Final technical report, 1 September 1978-31 August 1979

    Energy Technology Data Exchange (ETDEWEB)

    Maloney, T.J.; Habib, V.

    1979-08-01

    One Design, Inc., has designed and developed modular waterwall components that make up a system for passive solar space heating using a south-facing thermal storage wall. The modules can also be used as thermal mass storage for roof apertures and for greenhouse applications. The modules are constructed of fiberglass reinforced polyester and each is 95 inches long, 16.5 inches wide and 24.5 inches tall. Each module contains 94 gallons or 784 pounds of water. When stacked behind south glazing, they provide 52 Btu//sup 0/F per square foot of net glazed area. A stack of four modules has a height of 93.5 inches, suitable for an 8-foot interior ceiling; a stack of five modules is 116.5 inches high, suitable for a 10-foot interior ceiling. The modules are designed to stack on one another without requiring additional hardware and nest inside each other to reduce shipping costs. Prototype modules were fabricated and subjected to structural tests. They were found to be capable of supporting at least 4.8 times the load imposed by a five tank stack, well above the recommended safety factor of 2. Long term purity of the water in the containers was tested and evaluated and found to be within acceptable limits. Prototype modules were installed in One Design's Star Tannery House near Winchester, Virginia, and performance was extensively monitored from January to April, 1979. Based on the performance during the period, it has been estimated that the passive solar heating contribution would be 79.5% of the house's total heating requirement.

  5. Solar central receiver hybrid power system, Phase I. Volume 2. Conceptual design. Final technical report, October 1978-August 1979

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-09-01

    The objectives of this study were to develop a hybrid power system design that (1) produces minimum cost electric power, (2) minimizes the capital investment and operating cost, (3) permits capacity displacement, (4) and achieves utility acceptance for market penetration. We have met the first three of these objectives and therefore believe that the fourth, utility acceptance, will become a reality. These objectives have been met by utilizing the Martin Marietta concept that combines the alternate central receiver power system design and a high-temperature salt primary heat transfer fluid and thermal storage media system with a fossil-fired nonsolar energy source. Task 1 reviewed the requirements definition document and comments and recommendations were provided to DOE/San Francisco. Task 2 consisted of a market analysis to evaluate the potential market of solar hybrid power plants. Twenty-two utilities were selected within nine regions of the country. Both written and verbal correspondence was used to assess solar hybrid power plants with respect to the utilities' future requirements and plans. The parametric analysis of Task 3 evaluated a wide range of subsystem configurations and sizes. These analyses included subsystems from the solar standalone alternate central receiver power system using high-temperature molten salt and from fossil fuel nonsolar subsystems. Task 4, selection of the preferred commerical system configuration, utilized the parametric analyses developed in Task 3 to select system and subsystem configurations for the commercial plant design. Task 5 developed a conceptual design of the selected commercial plant configuration and assessed the related cost and performance. Task 6 assessed the economics and performance of the selected configuration as well as future potential improvements or limitations of the hybrid power plants.

  6. Ground motion following selection of SRS design basis earthquake and associated deterministic approach. Final report: Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1991-03-01

    This report summarizes the results of a deterministic assessment of earthquake ground motions at the Savannah River Site (SRS). The purpose of this study is to assist the Environmental Sciences Section of the Savannah River Laboratory in reevaluating the design basis earthquake (DBE) ground motion at SRS during approaches defined in Appendix A to 10 CFR Part 100. This work is in support of the Seismic Engineering Section`s Seismic Qualification Program for reactor restart.

  7. Phase 1: conceptual design. Ocean thermal energy conversion power system development. Volume 2 of 3. Technical details. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1978-01-30

    Westinghouse has completed the conceptual design of the Power System for the Ocean Thermal Energy Conversion (OTEC) Demonstration Plant project. This study included the development of a conceptual design for the following three items: first, a full-size power system module for the 100 MWe Demonstration Plant; second, a scaled proof of concept power system; and third, a heat exchanger test article. The study was limited to a closed cycle ammonia power system module, using a water temperature difference of 40/sup 0/F., and a surface platform/ship reference hull. Two power module of 50 MWe each are recommended for the demonstration plant. The 50 MWe module was selected since it has the lowest cost, and since it is of a size which convincingly demonstrates that future economically viable commercial plants, having reliable operation with credible anticipated costs, are possible. A modular, tube bundle approach to heat exchanger design makes large heat exchangers practical and economical. Other power module elements are considered to be within state-of-practice. Technological assessments of all subsystems indicate requirements for verification only, rather than continued research. A complete test program, which will verify the mechanical reliability as well as thermal performance, is recommended.

  8. Integrated Design for Marketing and Manufacturing team: An examination of LA-ICP-AES in a mobile configuration. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1994-05-01

    The Department of Energy (DOE) has identified the need for field-deployable elemental analysis devices that are safer, faster, and less expensive than the fixed laboratory procedures now used to screen hazardous waste sites. As a response to this need, the Technology Integration Program (TIP) created a mobile, field-deployable laser ablation-inductively coupled plasma-atomic emission spectrometry (LA-ICP-AES) sampling and analysis prototype. Although the elemental. screening prototype has been successfully field-tested, continued marketing and technical development efforts are required to transfer LA-ICP-AES technology to the commercial sector. TIP established and supported a student research and design group called the Integrated Design for Marketing and Manufacturing (IDMM) team to advance the technology transfer of mobile, field-deployable LA-ICP-AES. The IDMM team developed a conceptual design (which is detailed in this report) for a mobile, field-deployable LA-ICP-AES sampling and analysis system, and reports the following findings: Mobile, field-deployable LA-ICP-AES is commercially viable. Eventual regulatory acceptance of field-deployable LA-ICP-AES, while not a simple process, is likely. Further refinement of certain processes and components of LA-ICP-AES will enhance the device`s sensitivity and accuracy.

  9. FDA Approvals - Cancer Currents Blog

    Science.gov (United States)

    A catalog of posts from NCI’s Cancer Currents blog on new Food and Drug Administration approvals of cancer drugs. All posts include summaries of the evidence to support the new approvals and what they mean for patients.

  10. Drugs Approved for Skin Cancer

    Science.gov (United States)

    ... Ask about Your Treatment Research Drugs Approved for Skin Cancer This page lists cancer drugs approved by the Food and Drug Administration (FDA) for skin cancer, including drugs for basal cell carcinoma, melanoma, and ...

  11. Designation of Alpha-Phenylacetoacetonitrile (APAAN), a Precursor Chemical Used in the Illicit Manufacture of Phenylacetone, Methamphetamine, and Amphetamine, as a List I Chemical. Final rule.

    Science.gov (United States)

    2017-07-14

    The Drug Enforcement Administration (DEA) is finalizing the designation of the chemical alpha-phenylacetoacetonitrile (APAAN) and its salts, optical isomers, and salts of optical isomers, as a list I chemical under the Controlled Substances Act (CSA). The DEA proposed control of APAAN, due to its use in clandestine laboratories to illicitly manufacture the schedule II controlled substances phenylacetone (also known as phenyl-2-propanone or P2P), methamphetamine, and amphetamine. This rulemaking finalizes, without change, the control of APAAN as a list I chemical. This action does not establish a threshold for domestic and international transactions of APAAN. As such, all transactions involving APAAN, regardless of size, shall be regulated. In addition, chemical mixtures containing APAAN are not exempt from regulatory requirements at any concentration. Therefore, all transactions of chemical mixtures containing any quantity of APAAN shall be regulated pursuant to the CSA. However, manufacturers may submit an application for exemption for those mixtures that do not qualify for automatic exemption.

  12. 76 FR 55842 - Partial Approval and Partial Disapproval of Air Quality Implementation Plans; California; San...

    Science.gov (United States)

    2011-09-09

    ... October 2011. 2. Rule 4401--Steam Enhanced Crude Oil Production Wells--final limited approval/disapproval January 26, 2010 (75 FR 3996). Amendments submitted to EPA on July 28, 2011. 3. Rule 4402--Crude Oil Production Sumps--final limited approval/ disapproval July 7, 2011 (76 FR 39777). District...

  13. 75 FR 59084 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Control Technique...

    Science.gov (United States)

    2010-09-27

    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; Maryland; Control...). ACTION: Direct final rule. SUMMARY: EPA is taking direct final action to approve a State Implementation Plan (SIP) revision submitted by the State of Maryland. This SIP revision pertains to the control...

  14. New Concepts in Fish Ladder Design, Volume III of IV, Assessment of Fishway Development and Design, 1982-1983 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Powers, Patrick D.; Orsborn, John F.

    1985-08-01

    This volume covers the broad, though relatively short, historical basis for this project. The historical developments of certain design features, criteria and research activities are traced. Current design practices are summarized based on the results of an international survey and interviews with agency personnel and consultants. The fluid mechanics and hydraulics of fishway systems are discussed. Fishways (or fishpasses) can be classified in two ways: (1) on the basis of the method of water control (chutes, steps (ladders), or slots); and (2) on the basis of the degree and type of water control. This degree of control ranges from a natural waterfall to a totally artificial environment at a hatchery. Systematic procedures for analyzing fishways based on their configuration, species, and hydraulics are presented. Discussions of fish capabilities, energy expenditure, attraction flow, stress and other factors are included.

  15. Design of 9-meter carbon-fiberglass prototype blades : CX-100 and TX-100 : final project report.

    Energy Technology Data Exchange (ETDEWEB)

    Berry, Derek (TPI Composites, Inc., Warren, RI)

    2007-09-01

    TPI Composites, Inc. (TPI), Global Energy Concepts, LLC (GEC), and MDZ Consulting (MDZ) have collaborated on a project to design, manufacture, and test prototype carbon-fiberglass hybrid wind turbine blades of 9-m length. The project, funded by Sandia National Laboratories, involves prototype blades in both conventional (unidirectional spar fibers running along the blade span) and ''adaptive'' (carbon fibers in off-axis orientation to achieve bend-twist-coupling) configurations. After manufacture, laboratory testing is being conducted to determine the static and fatigue strength of the prototypes, in conjunction with field testing to evaluate the performance under operational conditions.

  16. Uranium Mill Tailings Remedial Action Project (UMTRAP), Slick Rock, Colorado, Revision 1, Volume 3. Calculations, Final design for construction

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    Volume three contains calculations for: site hydrology--rainfall intensity, duration, and frequency relations; site hydrology-- probable maximum precipitation; erosion protection--rock quality evaluation; erosion protection--embankment top and side slope; erosion protection--embankment toe apron; erosion protection-- gradations and layer thicknesses; Union Carbide site--temporary drainage ditch design; Union Carbide site--retention basin sediment volume; Union Carbide site--retention basin sizing; Burro Canyon site temporary drainage--temporary drainage facilities; and Union Carbide site temporary drainage--water balance.

  17. Compressed air energy storage: preliminary design and site development program in an aquifer. Final draft, Task 1: establish facility design criteria and utility benefits

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    Compressed air energy storage (CAES) has been identified as one of the principal new energy storage technologies worthy of further research and development. The CAES system stores mechanical energy in the form of compressed air during off-peak hours, using power supplied by a large, high-efficiency baseload power plant. At times of high electrical demand, the compressed air is drawn from storage and is heated in a combustor by the burning of fuel oil, after which the air is expanded in a turbine. In this manner, essentially all of the turbine output can be applied to the generation of electricity, unlike a conventional gas turbine which expends approximately two-thirds of the turbine shaft power in driving the air compressor. The separation of the compression and generation modes in the CAES system results in increased net generation and greater premium fuel economy. The use of CAES systems to meet the utilities' high electrical demand requirements is particularly attractive in view of the reduced availability of premium fuels such as oil and natural gas. This volume documents the Task 1 work performed in establishing facility design criteria for a CAES system with aquifer storage. Information is included on: determination of initial design bases; preliminary analysis of the CAES system; development of data for site-specific analysis of the CAES system; detailed analysis of the CAES system for three selected heat cycles; CAES power plant design; and an economic analysis of CAES.

  18. Simple visualization techniques for die casting part and die design. Final report, July 1, 1995--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Miller, R.A.; Lu, S.C.; Rebello, A.B.

    1998-05-01

    The objective of this work was to develop and test die casting design evaluation techniques based on the visualization of geometric data that is related to potential defects of problems. Specifically, thickness information is used to provide insight into potential thermal problems in the part and die. Distance from the gate and a special type of animation of the fill pattern is used to provide an assessment of gate, vent and overflow locations. Techniques have been developed to convert part design information in the form of STL files to a volume-based representation called a voxel model. The use of STL files makes the process CAD system independent. Once in voxel form, methods that were developed in this work are used to identify thick regions in the part, thin regions in the part and/or die, distance from user specified entry locations (gates), and the qualitative depiction of the fill pattern. The methods were tested with a prototype implementation on the UNIX platform. The results of comparisons with numerical simulation and field reported defects were surprisingly good. The fill-related methods were also compared against short-shots and a water analog study using high speed video. The report contains the results of the testing plus detailed background material on the construction of voxel models, the methods used for displaying results, and the computational geometric reasoning methods used to create die casting-related information form the voxel model for display to the user.

  19. Grid-connected integrated community energy system. Phase II, Stage 1, final report. Conceptual design: pyrolysis and waste management systems

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-08

    The University of Minnesota is studying and planning a grid-connected integrated community energy system to include disposal of wastes from health centers and utilizing the heat generated. Following initial definition of the 7-county metropolitan region for which the solid waste management system is to be planned, information is then necessary about the nature of the waste generated within this region. Estimates of the quantities generated, generation rates, and properties of the waste to be collected and disposed of are required in order to determine the appropriate size and capacity of the system. These estimates are designated and subsequently referred to as ''system input''. Institutional information is also necessary in designing the planned system, to be compatible with existing institutional operations and procedures, or to offer a minimum amount of problems to the participating institution in the region. Initial considerations of health care institutions generating solid waste within the defined region are made on a comprehensive basis without any attempt to select out or include feasible candidate institutions, or institutional categories. As the study progresses, various criteria are used in selecting potential candidate institutional categories and institutions within the 7-county region as offering the most feasible solid waste system input to be successfully developed into a centralized program; however, it is hoped that such a system if developed could be maintained for the entire 7-county region, and remain comprehensive to the entire health care industry. (MCW)

  20. Automotive gas turbine ceramic regenerator design and reliability program. Final annual report, July 1, 1975--September 30, 1976

    Energy Technology Data Exchange (ETDEWEB)

    Cook, J.A.; Fucinari, C.A.; Lingscheit, J.N.; Rahnke, C.J.

    1976-10-01

    The primary objective of the ERDA/Ford Ceramic Regenerator Design and Reliability Program is to develop ceramic regenerator cores that can be used in passenger car gas turbine engines, Stirling engines, and industrial/truck gas turbine engines. Specific durability objectives are defined as achieving a B/sub 10/ life of 10,000 hours on a truck/industrial gas turbine engine duty cycle. Previous reports, under this program, summarized operating experience on lithium aluminum silicate (LAS) ceramic regenerator cores obtained at Ford Motor Company. The primary cause of failure of these regenerators was determined to be chemical attack of the LAS material. Improved materials and design concepts aimed at reducing or eliminating chemical attack were placed on durability test in Ford 707 industrial gas turbine engines late in 1974. A description is given of the results of 18,500 hours of turbine engine durability testing accumulated during the period from July 1, 1975 to Sept. 30, 1976. Two materials, aluminum silicate and magnesium aluminum silicate continue to show promise toward achieving the durability objectives of this program. Regenerator cores made from aluminum silicate show no evidence of chemical attack damage after 5600 hours of engine test.

  1. Simple visualization techniques for die casting part and die design. Final report, July 1, 1995--September 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    Miller, R.A.; Lu, S.C.; Rebello, A.B.

    1998-05-01

    The objective of this work was to develop and test die casting design evaluation techniques based on the visualization of geometric data that is related to potential defects of problems. Specifically, thickness information is used to provide insight into potential thermal problems in the part and die. Distance from the gate and a special type of animation of the fill pattern is used to provide an assessment of gate, vent and overflow locations. Techniques have been developed to convert part design information in the form of STL files to a volume-based representation called a voxel model. The use of STL files makes the process CAD system independent. Once in voxel form, methods that were developed in this work are used to identify thick regions in the part, thin regions in the part and/or die, distance from user specified entry locations (gates), and the qualitative depiction of the fill pattern. The methods were tested with a prototype implementation on the UNIX platform. The results of comparisons with numerical simulation and field reported defects were surprisingly good. The fill-related methods were also compared against short-shots and a water analog study using high speed video. The report contains the results of the testing plus detailed background material on the construction of voxel models, the methods used for displaying results, and the computational geometric reasoning methods used to create die casting-related information from the voxel model for display to the user.

  2. Linaclotide: first global approval.

    Science.gov (United States)

    McWilliams, Vanessa; Whiteside, Glenn; McKeage, Kate

    2012-11-12

    Linaclotide is a once-daily, orally administered, first-in-class agonist of guanylate cyclase-C that is minimally absorbed. It is being developed to treat gastrointestinal disorders by Ironwood Pharmaceuticals and its partners, Forest Laboratories (North America), Almirall (Europe) and Astellas Pharma (Asia-Pacific). Linaclotide has received its first global approval in the US for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC), and a marketing submission has been filed in the EU for IBS-C. This article summarizes the milestones in the development of linaclotide leading to this first approval for IBS-C and CIC. This profile has been extracted and modified from the Adis R&D Insight drug pipeline database. Adis R&D Insight tracks drug development worldwide through the entire development process, from discovery, through pre-clinical and clinical studies to market launch.

  3. Rucaparib: First Global Approval.

    Science.gov (United States)

    Syed, Yahiya Y

    2017-04-01

    Rucaparib (Rubraca™) is an oral, small molecule, poly (ADP-ribose) polymerase inhibitor being developed by Clovis Oncology, Inc. (Boulder, CO, USA) for the treatment of solid tumours. It has been approved in the USA as monotherapy for the treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies. A marketing authorization application for rucaparib for the same indication has been submitted to the European Medicines Agency. Rucaparib is also under phase II or III investigation in ovarian, breast and prostate cancer. This article summarizes the milestones in the development of rucaparib leading to this first approval for ovarian cancer.

  4. Final Design for an International Intercomparison Exercise for Nuclear Accident Dosimetry at the DAF Using Godiva-IV: IER-148 CED-2 Report

    Energy Technology Data Exchange (ETDEWEB)

    Heinrichs, Dave [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Beller, Tim [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Burch, Jennifer [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Cummings, Rick [National Security Technologies, LLC. (NSTec), Mercury, NV (United States) Nevada National Security Site; Duluc, Matthieu [Inst. de Radioprotection et de Sûrete Nucleaire (ISRN), Fontenay-aux-Roses (France); Gadd, Milan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Goda, Joetta [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hickman, David [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); McAvoy, Doug [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Rathbone, Bruce [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sullivan, Randy [Savannah River Site (SRS), Aiken, SC (United States); Trompier, Francois [Inst. de Radioprotection et de Sûrete Nucleaire (ISRN), Fontenay-aux-Roses (France); Veinot, Ken [Y-12 National Security Complex, Oak Ridge, TN (United States); Ward, Dann [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Will, Rashelle [National Security Technologies, LLC. (NSTec), Mercury, NV (United States) Nevada National Security Site; Wilson, Chris [Atomic Weapons Establishment (AWE), Berkshire (United Kingdom); Zieziulewicz, Thomas [Knolls Atomic Power Lab. (KAPL), Niskayuna, NY (United States)

    2014-09-30

    This document is the Final Design (CED-2) Report for IER-148, “International Inter-comparison Exercise for Nuclear Accident Dosimetry at the DAF Using Godiva-IV.” The report describes the structure of the exercise consisting of three irradiations; identifies the participating laboratories and their points of contact; provides the details of all dosimetry elements and their placement in proximity to Godiva-IV on support stands or phantoms ; and lists the counting and spectroscopy equipment each laboratory will utilize in the Mercury NAD Lab. The exercise is tentatively scheduled for one week in August 2015.

  5. Worksite interventions for preventing physical deterioration among employees in job-groups with high physical work demands: background, design and conceptual model of FINALE

    DEFF Research Database (Denmark)

    Holtermann, Andreas; Jørgensen, Marie B; Gram, Bibi;

    2010-01-01

    A mismatch between individual physical capacities and physical work demands enhance the risk for musculoskeletal disorders, poor work ability and sickness absence, termed physical deterioration. However, effective intervention strategies for preventing physical deterioration in job groups with high...... physical demands remains to be established. This paper describes the background, design and conceptual model of the FINALE programme, a framework for health promoting interventions at 4 Danish job groups (i.e. cleaners, health-care workers, construction workers and industrial workers) characterized by high...... physical work demands, musculoskeletal disorders, poor work ability and sickness absence....

  6. Ipilimumab: first global approval.

    Science.gov (United States)

    Cameron, Fiona; Whiteside, Glenn; Perry, Caroline

    2011-05-28

    Ipilimumab (Yervoy®) is an anti-cytotoxic T-lymphocyte antigen (CTLA)-4 monoclonal antibody that has been approved in the US for the first- or second-line treatment of patients with malignant melanoma. In the EU, it is awaiting approval as second-line therapy for melanoma. Ipilimumab blocks the effects of the negative T-cell regulator CTLA-4, which may in turn augment T-cell responses to tumour cells. Preclinical studies have indicated that antibody blocking of CTLA-4 can lead to potent immune responses. Ipilimumab is also in development as first- and second-line therapy for prostate cancer where it has progressed to phase III clinical trials worldwide, and it is in phase II development for non-small cell lung cancer. Ipilimumab was originated by the University of California, Berkeley, in the US and subsequently licensed to Medarex, which was later acquired by Bristol-Myers Squibb. This article summarizes the milestones in the development of intravenous ipilimumab leading to this first approval. This profile has been extracted from Wolters Kluwer's R&D Insight drug pipeline database. R&D Insight tracks drug development worldwide through the entire development process, from discovery, through pre-clinical and clinical studies to market launch.

  7. Baricitinib: First Global Approval.

    Science.gov (United States)

    Markham, Anthony

    2017-03-13

    Baricitinib (Olumiant™) is an orally-administered, small-molecule, janus-associated kinase (JAK) inhibitor developed by Eli Lilly and Incyte Corporation for the treatment of rheumatoid arthritis (RA), atopic dermatitis and systemic lupus erythematosus. JAKs transduce intracellular signals from cell surface receptors for various cytokines and growth factors involved in inflammation and immune function, suggesting JAK inhibitors may be of therapeutic benefit in inflammatory conditions. In February 2017, baricitinib was approved in the EU, as monotherapy or in combination with methotrexate, for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs (DMARDs). Regulatory approval to market baricitinib as a treatment for RA has also been sought in the USA and Japan. This article summarizes the milestones in the development of baricitinib leading to this first global approval for the treatment for moderate to severe active RA in adult patients who have responded inadequately to, or are intolerant to one or more DMARDs.

  8. Evolocumab: First Global Approval.

    Science.gov (United States)

    Markham, Anthony

    2015-09-01

    Evolocumab (Repatha™) is a fully human monoclonal antibody developed by Amgen that has been approved as a treatment for hypercholesterolaemia in the EU, and is awaiting approval in the USA and Japan. It specifically binds proprotein convertase subtilisin/kexin type 9 (PCSK9)-a negative regulator of low-density lipoprotein (LDL)-receptors-thereby improving the ability of the liver to bind LDL-cholesterol (LDL-C), leading to reduced LDL-C blood levels. The drug reduces LDL-C levels in patients with hypercholesterolaemia when used as monotherapy or in conjunction with a statin. This article summarizes the milestones in the development of evolocumab leading to this approval for the treatment of adults with primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia as an adjunct to diet with or without a statin and/or other lipid lowering therapies, and in adults and adolescents aged ≥12 years with homozygous familial hypercholesterolaemia in combination with other lipid lowering therapies.

  9. Design and operating parameters for emission control studies: Phelps Dodge, Ajo, copper smelter. Final task report, Apr--Oct 1975

    Energy Technology Data Exchange (ETDEWEB)

    Weisenberg, I.J.; Serne, J.C.

    1976-02-01

    The report gives background design data for a specific copper smelter. The data is sufficiently detailed to allow air pollution control system engineering studies to be conducted. These studies will be concerned primarily with lean SO/sup 2/ streams that currently are not being captured. Physical layout of the smelter and the surrounding area is presented, along with existing control equipment. Ductwork that would be considered for future system tie-in is defined. Emissions from operating equipment, gas flow rates, temperatures, sulfur balance, and a process flow sheet are included. Utilities, stack dimensions, footing requirements, and solid waste handling are defined. Available area for new control equipment, gas characteristic variation, and potential new control equipment installation problems are discussed. (GRA)

  10. Final Report: Rational Design of Wide Band Gap Buffer Layers for High-Efficiency Thin-Film Photovoltaics

    Energy Technology Data Exchange (ETDEWEB)

    Lordi, Vincenzo [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-09-30

    The main objective of this project is to enable rational design of wide band gap buffer layer materials for CIGS thin-film PV by building understanding of the correlation of atomic-scale defects in the buffer layer and at the buffer/absorber interface with device electrical properties. Optimized wide band gap buffers are needed to reduce efficiency loss from parasitic absorption in the buffer. The approach uses first-principles materials simulations coupled with nanoscale analytical electron microscopy as well as device electrical characterization. Materials and devices are produced by an industrial partner in a manufacturing line to maximize relevance, with the goal of enabling R&D of new buffer layer compositions or deposition processes to push device efficiencies above 21%. Cadmium sulfide (CdS) is the reference material for analysis, as the prototypical high-performing buffer material.

  11. Opportunities for Russian Nuclear Weapons Institute developing computer-aided design programs for pharmaceutical drug discovery. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-23

    The goal of this study is to determine whether physicists at the Russian Nuclear Weapons Institute can profitably service the need for computer aided drug design (CADD) programs. The Russian physicists` primary competitive advantage is their ability to write particularly efficient code able to work with limited computing power; a history of working with very large, complex modeling systems; an extensive knowledge of physics and mathematics, and price competitiveness. Their primary competitive disadvantage is their lack of biology, and cultural and geographic issues. The first phase of the study focused on defining the competitive landscape, primarily through interviews with and literature searches on the key providers of CADD software. The second phase focused on users of CADD technology to determine deficiencies in the current product offerings, to understand what product they most desired, and to define the potential demand for such a product.

  12. Final design, installation and baseline testing of 500 kW direct contact pilot plant at East Mesa

    Energy Technology Data Exchange (ETDEWEB)

    Hlinak, A.; Lobach, J.; Nichols, K.; Olander, R.; Werner, D.

    1980-05-30

    The pilot plant was configured to accomplish two objectives - first to evaluate the overall performance potential of direct contact powerplants and second to develop design criteria and parameters for full-scale direct contact plants. The pilot plant includes all of the process functions that would be incorporated in a full-scale plant. Incoming brine is treated to remove undissolved gases, pumped through the direct contact heat exchanger (DCHX), and then sent to a recovery system for removal of the dissolved working fluid. The chosen working fluid is isobutane (IC/sub 4/). The working fluid loop includes a radial inflow turbine with generator, condensers, hot-well reservoir, and a feed pump. A downwell pump was installed in the geothermal well to supply the plant with unflashed brine. (MHR)

  13. Design and testing of a continuous metal biosorption system. Final report, March 10, 1994--June 9, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Faison, B.D.; Hu, M.Z.C.; Reeves, M.E. [Oak Ridge National Lab., TN (United States); McGraw, T.F.; Gupte, U.; Haris, W.G. [Scientific and Commercial Systems Corp., Beltsville, Maryland (United States)

    1995-12-31

    The research pursued in this project consisted of two portions that were conducted with constant coordination to allow the ultimate merger of research results. ORNL was assigned the task of developing the biomass portion of the bioreactor, while SCSC was responsible for the mechanical portions of the bioreactor. This report describes the technical aspects of a novel biological sorbent, consisting of microbial biomass immobilized within a polyurethane gel matrix, that was developed and characterized (on a bench scale, within batch and flow-through systems) for use in a novel, continuous-flow bioreactor system. The report also addresses an initial effort to develop a delivery technology that takes advantage of the specific characteristics of the biosorbent material to permits its deployment against contamination problems. The report concludes with recommendations for future work that would allow the designated wastes to be treated on a large scale.

  14. Project to design and develop an energy-related program: For public housing residents and renters: Volume 1, Final report

    Energy Technology Data Exchange (ETDEWEB)

    1988-05-01

    This demonstration project was undertaken as a result of an unsolicited proposal submitted by THE ASSIGNMENT GROUP (TAG) to the Office of Minority Economic Impact, Department of Energy (DOE). The problem to which the proposal responded was how to minimize the costs associated with public housing tenants in standard public housing as well as under homeownership transfers. A related problem was how to graduate the tenants to another level of responsibility and self-sufficiency through resident business developments and training in energy-related fields. The size and gravity of the problem necessitated a purpose or aim that had nationwide application, yet lent itself to a microscopic look. Consequently, the goal that emanated was the design and development of an energy-related demonstration program that educates public housing residents, facilitates indigenous business development where appropriate, and trains residents to provide needed services.

  15. Design and Development of Aerogel-Based Antennas for Aerospace Applications: A Final Report to the NARI Seedling

    Science.gov (United States)

    Meador, Mary Ann B.; Miranda, Felix A.

    2014-01-01

    As highly porous solids possessing low density and low dielectric permittivity combined with good mechanical properties, polyimide (PI) aerogels offer great promise as an enabling technology for lightweight aircraft antenna systems. While they have been aggressively explored for thermal insulation, barely any effort has been made to leverage these materials for antennas or other applications that take advantage of their aforementioned attributes. In Phase I of the NARI Seedling Project, we fabricated PI aerogels with properties tailored to enable new antenna concepts with performance characteristics (wide bandwidth and high gain) and material properties (low density, environmental stability, and robustness) superior to the state of practice (SOP). We characterized electromagnetic properties, including permittivity, reflectivity, and propagation losses for the aerogels. Simple, prototype planar printed circuit patch antennas from down-selected aerogel formulations were fabricated by molding the aerogels to net shapes and by gold-metalizing the pattern onto the templates via electron beam evaporation in a clean room environment. These aerogel based antennas were benchmarked against current antenna SOP, and exhibited both broader bandwidth and comparable or higher gain performance at appreciably lower mass. Phase II focused on the success of the Phase I results pushing the PI aerogel based antenna technology further by exploring alternative antenna design (i.e., slot coupled antennas) and by examining other techniques for fabricating the antennas including ink jet printing with the goal of optimizing antenna performance and simplifying production. We also examined new aerogel formulations with better moisture and solvent resistance to survive processing conditions. In addition, we investigated more complex antenna designs including passive phased arrays such as 2x4 and 4x8 element arrays to assess the scalability of the aerogel antenna concept. Furthermore, we

  16. Design guide for composite-material flywheels: rotor dyamic considerations. Part I. System whirling and stability. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Bert, C.W.; Ramunujam, G.

    1981-09-01

    Information to designers of flywheels is provided which will enable them to predict many aspects of the dynamic behavior of their flywheel systems when spin-tested with a quill-shaft support and driven by an air turbine. Computer programs are presented for the following dynamic analysis to obtain the results indicated: free whirling for natural frequencies versus rotational speed and the associated mode shapes; rough-type stability analysis for determining the stability limits; and forced whirling analysis for estimating the response of major components of the system to flywheel mass eccentricity and initial tilt. For the first and third kinds of analyses, two different mathematical models of the generic system are investigated. One is a seven-degree-of-freedom lumped-parameter analysis, while the other is a combined distributed- and lumped-parameter analysis. When applied to an existing flywheel system, the two models yielded numerical values for the lowest first-order forward critical speed in very close agreement with each other and with experimental results obtained in spin tests. Therefore, for the second kind of analysis, only the lumped-parameter model is implemented. Qualitative discussions as to why forced retrograde whirling is not as severe as forward whirling are also presented. The analyses are applied to the multi-material ring type flywheel systems, a constant-thickness-diskring type, and a tapered-thickness-disk type. In addition, the effects of the following flywheel design parameters on system dynamics were investigated: flywheel mass; diametral and polar mass moments of inertia; location of mass center from the lower end of the quill shaft; quill shaft length; lower turbine-bearing support stiffness; equivalent viscous damping coefficient of the external damper; flywheel dead weight; and torque applied at the turbine.

  17. 7 CFR 1724.54 - Requirements for RUS approval of plans and specifications.

    Science.gov (United States)

    2010-01-01

    ... specifications for transmission construction projects which are not based on RUS approved line design data or do... building design meets the Uniform Federal Accessibility Standards (See § 1724.51(e)(1)(i)). (g... DESIGN POLICIES AND PROCEDURES Electric System Design § 1724.54 Requirements for RUS approval of...

  18. 49 CFR 178.74 - Approval of MEGCs.

    Science.gov (United States)

    2010-10-01

    ... this chapter +to obtain approval of a new design. When a series of MEGCs is manufactured without change... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR...

  19. The non-independence discussion about cycle structure in the computer language: the final simplification of computer language in the structural design

    Science.gov (United States)

    Yang, Peilu

    2013-03-01

    In the first place, the article discusses the theory, content, development, and questions about structured programming design. The further extension on this basement provides the cycle structure in computer language is the sequence structure, branch structure, and the cycle structure with independence. Through the deeply research by the writer, we find the non-independence and reach the final simplification about the computer language design. In the first, the writer provides the language structure of linear structure (I structure) and curvilinear structure (Y structure). This makes the computer language has high proficiency with simplification during the program exploration. The research in this article is corresponding with the widely used dualistic structure in the computer field. Moreover, it is greatly promote the evolution of computer language.

  20. (Design and operation of a portable ethanol plant). Final report. [Small-scale (5-10 gal/h)

    Energy Technology Data Exchange (ETDEWEB)

    Glenn, K.C.

    1983-09-25

    A portable distillation plant with a packed reflux column was designed and built that is capable of producing 10 to 15 gallons of 190 proof ethanol per hour. Several kinds of feedstocks were used to produce ethanol. Corn served as a good feedstock and was easily processed in the still. However, because of the present high prices of corn and the manual labor for operation it cannot be used to produce ethanol commercially as a fuel at prices competitive with petroleum fuels. Cellulosic feedstocks such as paper, sawdust and grasses and leaves were enzymatically degraded to sugars and fermented to ethanol. Because of the manual labor required and small capacity of the still total operation costs would preclude competitive fuel prices. However, such a plant could be used on a farm for production of a supplementary fuel or for independence from petroleum fuels. The trials with cellulosic materials did give evidence that such feedstocks are plausible sources for ethanol when produced on a large scale in an automated production plant. On a large scale basis ethanol could be produced competitively as an alternative fuel for gasoline.

  1. Evaluation of Fishway Designs for Downstream Passage of Spring Chinook Salmon and Steelhead Trout Smolts, 1987 Final Report.

    Energy Technology Data Exchange (ETDEWEB)

    Congleton, J.L.; Wagner, E.J.; Ringe, R.R.

    1988-03-01

    The stress response of chinook salmon and steelhead trout smolts to passage through three different flumes was tested by assaying plasma cortisol concentrations before and after flume passage. In addition, descaling of fish was recorded before and after flume passage, and the ability of the flumes to pass adult chinook salmon and debris was determined. The three flumes were a corrugated metal flume (CMF), a 4- foot wide baffled flume (BF4), and a 2-foot wide baffled flume (BF2). Each flume was tested under conditions: 1) at night, 2) during the day with a perforated metal cover, which reduced the amount of light entering the flume by about half (partially darkened), and 3) during the day with the perforated cover and additional double layer of black plastic (completely darkened). Plasma cortisol concentrations were not significantly elevated in chinook salmon smolts after passage through any of the flumes (P>0.2, ANOVA). In daytime tests of partially and completely darkened flumes cortisol concentrations were consistently decreased following flume passage. We attribute this to pre-test stress (holding of fish in small tanks) and to the absence of a strong stress response to flume passage. Flume design did not have a significant effect on cortisol concentrations (P=0.9).Total darkening of the flumes during daytime was beneficial: cortisol concentrations were lower (P=0.03) in chinook salmon smolts passing through completely darkened flumes than in smolts passing through partially darkened flumes. 16 refs., 15 figs.

  2. Final design of the Energy-Resolved Neutron Imaging System “RADEN” at J-PARC

    Science.gov (United States)

    Shinohara, T.; Kai, T.; Oikawa, K.; Segawa, M.; Harada, M.; Nakatani, T.; Ooi, M.; Aizawa, K.; Sato, H.; Kamiyama, T.; Yokota, H.; Sera, T.; Mochiki, K.; Kiyanagi, Y.

    2016-09-01

    A new pulsed-neutron instrument, named the Energy-Resolved Neutron Imaging System “RADEN”, has been constructed at the beam line of BL22 in the Materials and Life Science Experimental Facility (MLF) of J-PARC. The primary purpose of this instrument is to perform energy-resolved neutron imaging experiments through the effective utilization of the pulsed nature of the neutron beam, making this the world's first instrument dedicated to pulsed neutron imaging experiments. RADEN was designed to cover a broad energy range: from cold neutrons with energy down to 1.05 meV (or wavelength up to 8.8 Å) with a good wavelength resolution of 0.20% to high-energy neutrons with energy of several tens keV (or wavelength of 10-3 Å). In addition, this instrument is intended to perform state-of-the-art neutron radiography and tomography experiments in Japan. Hence, a maximum beam size of 300 mm square and a high L/D value of up to 7500 are provided.

  3. HEAL G-C ICES, Phase II: detailed feasibility analysis and preliminary design. Final report, Stage 1

    Energy Technology Data Exchange (ETDEWEB)

    1978-03-22

    In this preliminary report for Phase II of Health Education Authority of Louisiana's (HEAL) ICES program, specific elements of the basic intitutional issues were readdressed, as requested by the U.S. Department of Energy. The draft environmental assessment was reassessed and updated. Thermal energy demand profiles for the major community sectors, i.e., the five institutions comprising the HEAL Complex, were refined on a month-by-month basis and resulted in establishing ICES plant systems design capacities of 121,500 pounds per hour demand and 418,175,000 pounds per year for steam; 10,000 tons demand and 38,885,000 ton-hours per year for cooling. From these values the concept of the plant was developed. The Phase I capital cost estimate was updated. Total capital cost is now indicated as $29,960,500. The Phase I operating cost estimate was updated, with that figure now $8,468,479. The Phase I financial analysis was updated, producing an estimated annual revenue level of $9,907,062.

  4. SRC burn test in 700-hp oil-designed boiler. Annex Volume A. Southern Research Institute report. Final technical report

    Energy Technology Data Exchange (ETDEWEB)

    1983-09-01

    Combustion tests were performed using three forms of Solvent Refined Coal (SRC) as the fuel for a 700 hp oil-designed water-tube boiler at the U.S. Department of Energy (DOE) Pittsburgh Energy Technology Center (PETC). This report contains the results from a program of measurements and analyses performed by Southern Research Institute (SoRI) under contract to the International Coal Refining Company (ICRC). The major objectives of the work performed by Southern Research Institute were: (1) to characterize the particulate matter resulting from the combustion of Solvent Refined Coal (SRC) and its fuel forms, and (2) to develop estimates of the specific collection areas required for varying levels of collection of fly ash from SRC combustion in electrostatic precipitators. The report contains physical and chemical characterizations of particles collected during the combustion experiments, and a discussion of electrostatic precipitation of SRC fly ash based on performance measurements with a small-scale precipitator and on simulations using a mathematical model. 9 references, 90 figures, 14 tables.

  5. Design, manufacture, test and delivery of a 230 kV extruded irradiated crosslinked polyethylene cable. Final report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    A project was initiated to develop a 230 kV solid dielectric cable for use in underground transmission. The dielectric is to be polyethylene, crosslinked by electron bombardment. Compared to the more conventional chemically crosslinked polyethylene, the irradiated cable is expected to contain less sensitive defects and thus be more suitable for a 230 kV rating. A toroidally shaped diode was developed to provide a uniform radiation dose to a thick-walled coaxial cable. The diode is to receive an output wave form obtained by ringing a Marx generator into a peaking capacitor. Initial evaluation of the toroidal diode was performed on thin plaques and tapes of insulating and semi-conducting polyethylene polymers. Additionally, some miscellaneous ethylene plastics were briefly investigated. Using a 4.8 MV Van de Graaff pulse generator in conjunction with several diode configurations, 15 to 35 kV extruded HMW-PE cables were irradiated. Dose rate, temperature, and pressure effects were evaluated. It was found that with limited dose rate it was possible to produce excellent crosslink density and uniformity at room temperature and atmospheric pressure. A subsequent 60 Hz voltage endurance test on an irradiated cable sample indicated it had long term, high stress capability. An engineering study conducted to determine an acceptable irradiator system design is reported. It was estimated that a 7 MV peak voltage at a rate of 2 to 3 pulse/sec can be provided by a Marx generator/peaking capacitor and should be capable of crosslinking a polyethylene wall thickness of approximately 2.5 cm. Based on the accumulated test results and on the performance of the 7 MV irradiator predicted, it appears feasible to continue the work effort into the next scheduled phase.

  6. Evaluation of dense-phase ultrafine coal (DUC) as a fuel alternative for oil- and gas-designed boilers and heaters. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1986-12-01

    Utility and industrial firms currently using oil- and gas-fired boilers have an interest in substitution of coal for oil and gas as the primary boiler fuel. This interest stems from coal`s two main advantages over oil and gas-lower cost and security of supply. Recent efforts in the area of coal conversion have been directed to converting oil- and gas- fired boilers which were originally designed for coal-firing or were designed with some coal-firing capability. Boilers designed exclusively for oil- or gas-firing have not been considered viable candidates for coal conversion because they generally require a significant capacity derating and extensive and costly modifications. As a result, conversion of boilers in this class to coal-firing has generally been considered unattractive. Renewed interest in the prospects for converting boilers designed exclusively for oil- and gas-firing to coal firing has centered around the concept of using ``ultra fine`` coal as opposed to ``conventional grind`` pulverized coal. The main distinction being the finer particle size to which the former is ground. This fuel type may have characteristics which ameliorate many of the boiler problems normally associated with pulverized coal-firing. The overall concept for ultrafine coal utilization is based on a regional large preparation plant with distribution of a ready to fire fuel directly to many small users. This differs from normal practice in which final coal sizing is performed in pulverizers at the user`s site.

  7. Ocean thermal energy conversion power system development-I. Preliminary design report. Volume 3. Appendixes D, E, and F. Phase I. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-18

    The conceptual design of a 40 to 50 MW closed cycle ammonia OTEC commercial plant, the preliminary design of a 10 MW OTEC module analogous to the 50 MW module, and the preliminary design of heat exchanger test articles (evaporator and condenser) representative of the 50 MW heat exchangers for testing in OTEC-1 are presented. This volume includes the appendices: D) system equipment (hardware breakdown structure; 10-MW hardware listing; list of support and maintenance equipment, tools and spare parts; sacrificial anodes; M.A.N. brush; and Alclad 3004 data); E) heat exchanger supporting data (analyses/configuration, contract tooling, manufacturing plan, specification, and evaporator ammonia liquid distribution system); and F) rotating machinery (performance characteristics, radial inflow turbine; item descriptions; weight calculation-rotor; producibility analysis; long lead-time items; spares; support equipment; non recurring costs; performance characteristics-axial flow turbine; Worthington pump data; and American M.A.N. Corporation data). Also included is attachment 1 to the phase I final report which presents details of the system modeling; design, materials considerations, and systems analysis of the baseline module; system cost analysis; and supporting data. (WHK)

  8. Material Performance of Fully-Ceramic Micro-Encapsulated Fuel under Selected LWR Design Basis Scenarios: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    B. Boer; R. S. Sen; M. A. Pope; A. M. Ougouag

    2011-09-01

    The extension to LWRs of the use of Deep-Burn coated particle fuel envisaged for HTRs has been investigated. TRISO coated fuel particles are used in Fully-Ceramic Microencapsulated (FCM) fuel within a SiC matrix rather than the graphite of HTRs. TRISO particles are well characterized for uranium-fueled HTRs. However, operating conditions of LWRs are different from those of HTRs (temperature, neutron energy spectrum, fast fluence levels, power density). Furthermore, the time scales of transient core behavior during accidents are usually much shorter and thus more severe in LWRs. The PASTA code was updated for analysis of stresses in coated particle FCM fuel. The code extensions enable the automatic use of neutronic data (burnup, fast fluence as a function of irradiation time) obtained using the DRAGON neutronics code. An input option for automatic evaluation of temperature rise during anticipated transients was also added. A new thermal model for FCM was incorporated into the code; so-were updated correlations (for pyrocarbon coating layers) suitable to estimating dimensional changes at the high fluence levels attained in LWR DB fuel. Analyses of the FCM fuel using the updated PASTA code under nominal and accident conditions show: (1) Stress levels in SiC-coatings are low for low fission gas release (FGR) fractions of several percent, as based on data of fission gas diffusion in UO{sub 2} kernels. However, the high burnup level of LWR-DB fuel implies that the FGR fraction is more likely to be in the range of 50-100%, similar to Inert Matrix Fuels (IMFs). For this range the predicted stresses and failure fractions of the SiC coating are high for the reference particle design (500 {micro}mm kernel diameter, 100 {micro}mm buffer, 35 {micro}mm IPyC, 35 {micro}mm SiC, 40 {micro}mm OPyC). A conservative case, assuming 100% FGR, 900K fuel temperature and 705 MWd/kg (77% FIMA) fuel burnup, results in a 8.0 x 10{sup -2} failure probability. For a &apos

  9. Final disposal of spent nuclear fuel in Sweden. Some unresolved issues and challenges in the design and implementation of the forthcoming planning and EIA processes

    Energy Technology Data Exchange (ETDEWEB)

    Bjarnadottir, H.; Hilding-Rydevik, T. [Nordregio, Stockholm (Sweden)

    2001-06-01

    The aim of the study is to highlight some unresolved and challenging issues in the forthcoming approximately six year long Environmental Impact Assessment (EIA) and planning process of the long-term disposal of spent nuclear fuel in Sweden. Different international and Nordic experiences of the processes for final disposal as well as from other development of similar scope, where experiences assumed to be of importance for final disposal of nuclear waste, have been described. Furthermore, issues relating to 'good EIA practice' as well as certain aspects of planning theory have also been presented. The current Swedish situation for the planning and EIA process of the final disposal of spent nuclear fuel was also been summarized. These different 'knowledge areas' have been compared and measured against our perception of the expectations towards the forthcoming process, put forward by different Swedish actors in the field. The result is a presentation of a number of questions and identification issues that the authors consider need special attention in the design and conduction of the planning and EIA process. The study has been realized through a literature survey and followed by reading and analysis of the written material. The main focus of the literature search was on material describing planning processes, actor perspectives and EIA. Material and literature on the technical and scientific aspects of spent nuclear fuel disposal was however deliberately avoided. There is a wealth of international and Swedish literature concerning final disposal of spent nuclear fuel - concerning both technical issues and issues concerning for example public participation and risk perception. But material of a more systematic and comparative nature (relating to both empirical and theoretical issues, and to practical experiences) in relation to EIA processes and communicative planning for final disposal of spent nuclear fuel seems to be more sparsely represented

  10. Conceptual design of advanced central receiver power systems sodium-cooled receiver concept. Volume 2, Book 1. Commercial plant conceptual design. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1979-03-01

    The conceptual design of the 100-MW solar tower focus commercial power plant is described in detail. Sodium is pumped up to the top of a tall tower where the receiver is located. The sodium is heated in the receiver and then flows down the tower, through a pressure reducing device, and thence into a large, hot storage tank which is located at ground level and whose size is made to meet a specific thermal energy storage capacity requirement. From this tank, the sodium is pumped by a separate pump, through a system of sodium-to-water steam generators. The steam generator system consists of a separate superheater and reheater operating in parallel and an evaporator unit operating in series with the other two units. The sodium flowing from the evaporator unit is piped to a cold storage tank. From the cold storage tank, sodium is then pumped up to the tip of the tower to complete the cycle. The steam generated in the steam generators is fed to a conventional off-the-shelf, high-efficiency turbine. The steam loop operates in a conventional rankine cycle with the steam generators serving the same purpose as a conventional boiler and water being fed to the evaporator with conventional feedwater pumps. The pressure reducing device (a standard drag valve, for example) serves to mitigate the pressure caused by the static head of sodium and thus allows the large tanks to operate at ambient pressure conditions. (WHK)

  11. The influence of design and fuel parameters on the particle emissions from wood pellets combustion. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Wiinikka, Henrik; Gebart, Rikard [Energy Technology Centre, Piteaa (Sweden)

    2005-02-01

    Combustion of solid biomass under fixed bed conditions is a common technique to generate heat and power in both small and large scale grate furnaces (domestic boilers, stoves, district heating plants). Unfortunately, combustion of biomass will generate particle emissions containing both large fly ash particles and fine particles that consist of fly ash and soot. The large fly ash particles have been produced from fusion of non-volatile ash-forming species in burning char particle. The inorganic fine particles have been produced from nucleation of volatilised ash elements (K, Na, S, Cl and Zn). If the combustion is incomplete, soot particles are also produced from secondary reaction of tar. The particles in the fine fraction grows by coagulation and coalescence to a particle diameter around 0.1 pm. Since the smallest particles are very hard to collect in ordinary cleaning devices they contribute to the ambient air pollution. Furthermore, fine airborne particles have been correlated to adverse effects on the human health. It is therefore essential to minimize particle formation from the combustion process and thereby reduce the emissions of particulates to the ambient air. The aim with this project is to study particle emissions from small scale combustion of wood pellets and to investigate the impact of different operating, construction and fuel parameters on the amount and characteristic of the combustion generated particles. To address these issues, experiments were carried out in a 10 kW updraft fired wood pellets reactor that has been custom designed for systematic investigations of particle emissions. In the flue gas stack, particle emissions were sampled on a filter. The particle mass and number size distributions were analysed by a low pressure cascade impactor and a SMPS (Scanning Electron Mobility Particle Sizer). The results showed that the temperature and the flow pattern in the combustion zone affect the particle emissions. Increasing combustion

  12. LCA-ship. Design tool for energy efficient ships. A Life Cycle Analysis Program for Ships. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Jiven, Karl; Sjoebris, Anders [MariTerm AB, Goeteborg (Sweden); Nilsson, Maria [Lund Univ. (Sweden). Stiftelsen TEM; Ellis, Joanne; Traegaardh, Peter; Nordstroem, Malin [SSPA Sweden AB, Goeteborg (Sweden)

    2004-05-01

    In order to make it easier to include aspects during ship design that will improve environmental performance, general methods for life cycle calculations and a prototype tool for LCA calculations of ships and marine transportation have been developed. The base of the life cycle analyses is a comprehensive set of life cycle data that was collected for the materials and consumables used in ship construction and vessel operations. The computer tool developed makes it possible to quickly and simply specify (and calculate) the use of consumables over the vessel's life time cycle. Special effort has been made to allow the tool to be used for different types of vessels and sea transport. The main result from the project is the computer tool LCA ship, which incorporates collected and developed life cycle data for some of the most important materials and consumables used in ships and their operation. The computer application also contains a module for propulsion power calculations and a module for defining and optimising the energy system onboard the vessel. The tool itself is described in more detail in the Computer application manual. The input to the application should, as much as possible, be the kind of information that is normally found in a shipping company concerning vessel data and vessel movements. It all starts with defining the ship to be analysed and continues with defining how the ship is used over the lifetime. The tool contains compiled and processed background information about specific materials and processes (LCA data) connected to shipping operations. The LCA data is included in the tool in a processed form. LCA data for steel will for example include the environmental load from the steel production, the process to build the steel structure of the ship, the scrapping and the recycling phase. To be able to calculate the environmental load from the use of steel the total amount of steel used over the life cycle of the ship is also needed. The

  13. LCA-ship. Design tool for energy efficient ships. A Life Cycle Analysis Program for Ships. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Jiven, Karl; Sjoebris, Anders [MariTerm AB, Goeteborg (Sweden); Nilsson, Maria [Lund Univ. (Sweden). Stiftelsen TEM; Ellis, Joanne; Traegaardh, Peter; Nordstroem, Malin [SSPA Sweden AB, Goeteborg (Sweden)

    2004-05-01

    In order to make it easier to include aspects during ship design that will improve environmental performance, general methods for life cycle calculations and a prototype tool for LCA calculations of ships and marine transportation have been developed. The base of the life cycle analyses is a comprehensive set of life cycle data that was collected for the materials and consumables used in ship construction and vessel operations. The computer tool developed makes it possible to quickly and simply specify (and calculate) the use of consumables over the vessel's life time cycle. Special effort has been made to allow the tool to be used for different types of vessels and sea transport. The main result from the project is the computer tool LCA ship, which incorporates collected and developed life cycle data for some of the most important materials and consumables used in ships and their operation. The computer application also contains a module for propulsion power calculations and a module for defining and optimising the energy system onboard the vessel. The tool itself is described in more detail in the Computer application manual. The input to the application should, as much as possible, be the kind of information that is normally found in a shipping company concerning vessel data and vessel movements. It all starts with defining the ship to be analysed and continues with defining how the ship is used over the lifetime. The tool contains compiled and processed background information about specific materials and processes (LCA data) connected to shipping operations. The LCA data is included in the tool in a processed form. LCA data for steel will for example include the environmental load from the steel production, the process to build the steel structure of the ship, the scrapping and the recycling phase. To be able to calculate the environmental load from the use of steel the total amount of steel used over the life cycle of the ship is also needed. The

  14. 30 CFR 18.11 - Approval plate.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Approval plate. 18.11 Section 18.11 Mineral... plate. (a)(1) The notice of approval will be accompanied by a photograph of an approval plate, bearing... number shall be added to the original approval number on the approval plate. (Example: Original approval...

  15. Ataluren: first global approval.

    Science.gov (United States)

    Ryan, Nicola J

    2014-09-01

    Nonsense mutations are implicated in 5-70 % of individual cases of most inherited diseases, including Duchenne muscular dystrophy (DMD) and cystic fibrosis. Ataluren (Translarna™) is an orally available, small molecule compound that targets nonsense mutations, and is the first drug in its class. Ataluren appears to allow cellular machinery to read through premature stop codons in mRNA, enabling the translation process to produce full-length, functional proteins. This article summarizes the milestones in the development of ataluren leading to its conditional first approval for nonsense mutation DMD.

  16. Field Demonstration of Active Desiccant Modules Designed to Integrate with Standard Unitary Rooftop Package Equipment - Final Report: Phase 3

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, J

    2004-03-15

    This report summarizes the investigation of two active desiccant module (ADM) pilot site installations initiated in 2001. Both pilot installations were retrofits at existing facilities served by conventional heating, ventilating, and air-conditioning (HVAC) systems that had encountered frequent humidity control, indoor air quality (IAQ), and other operational problems. Each installation involved combining a SEMCO, Inc., ADM (as described in Fischer and Sand 2002) with a standard packaged rooftop unit built by the Trane Company. A direct digital control (DDC) system integral to the ADM performed the dual function of controlling the ADM/rooftop combination and facilitating data collection, trending, and remote performance monitoring. The first installation involved providing preconditioned outdoor air to replace air exhausted from the large kitchen hood and bathrooms of a Hooters restaurant located in Rome, Georgia. This facility had previously added an additional rooftop unit in an attempt to achieve occupant comfort without success. The second involved conditioning the outdoor air delivered to each room of a wing of the Mountain Creek Inn at the Callaway Gardens resort. This hotel, designed in the ''motor lodge'' format with each room opening to the outdoors, is located in southwest Georgia. Controlling the space humidity always presented a serious challenge. Uncomfortable conditions and musty odors had caused many guests to request to move to other areas within the resort. This is the first field demonstration performed by Oak Ridge National Laboratory where significant energy savings, operating cost savings, and dramatically improved indoor environmental conditions can all be claimed as the results of a retrofit desiccant equipment field installation. The ADM/rooftop combination installed at the restaurant resulted in a reduction of about 34% in the electricity used by the building's air-conditioning system. This represents a reduction of

  17. Remedial Action Plan and Site Design for Stabilization of the Inactive Uranium Mill Tailings Site, Maybell, Colorado. Remedial action selection report: Attachment 2, Geology report, Final

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    The Maybell uranium mill tailings site is 25 miles (mi) (40 kilometers [km]) west of the town of Craig, Colorado, in Moffat County, in the northwestern part of the state. The unincorporated town of Maybell is 5 road mi (8 km) southwest of the site. The designated site covers approximately 110 acres (ac) (45 hectares [ha]) and consists of a concave-shaped tailings pile and rubble from the demolition of the mill buildings buried in the former mill area. Contaminated materials at the Maybell processing site include the tailings pile, which has an average depth of 20 feet (ft) (6 meters [m]) and contains 2.8 million cubic yards (yd{sup 3}) (2.1 million cubic meters [m{sup 3}]) of tailings. The former mill processing area is on the north side of the site and contains 20,000 yd{sup 3} (15,000 m{sup 3}) of contaminated demolition debris. Off-pile contamination is present and includes areas adjacent to the tailings pile, as well as contamination dispersed by wind and surface water flow. The volume of off-pile contamination to be placed in the disposal cell is 550,000 yd{sup 3} (420,000 m{sup 3}). The total volume of contaminated materials to be disposed of as part of the remedial action is estimated to be 3.37 million yd{sup 3} (2.58 million m{sup 3}). Information presented in this Final Remedial Action Plan (RAP) and referenced in supporting documents represents the current disposal cell design features and ground water compliance strategy proposed by the US Department of Energy (DOE) for the Maybell, Colorado, tailings site. Both the disposal cell design and the ground water compliance strategy have changed from those proposed prior to the preliminary final RAP document as a result of prudent site-specific technical evaluations.

  18. Guidance for package approvals in the United Kingdom

    Energy Technology Data Exchange (ETDEWEB)

    Morgan-Warren, E. [Radioactive Materials Transport Div., Dept. for Transport, London (United Kingdom)

    2004-07-01

    Approval is required under the transport regulations for a wide range of package designs and operations, and applications for competent authority approval and validation are received from many sources, both in the United Kingdom and overseas. To assist package designers and applicants for approval, and to promote consistency in applications and their assessment, the UK Department for Transport issues guidance on the interpretation of the transport regulations and the requirements of an application for approval and its supporting safety case. The general guidance document, known as the ''Guide to an Application for UK Competent Authority Approval of Radioactive Material in Transport'', has been issued for many years and updated to encompass the provisions of each successive edition of the IAEA transport regulations. The Guide has been referred to in a number of international fora, including PATRAM, and was cited as a ''Good Practice'' in the report of the IAEA TRANSAS Appraisal of the UK in 2002. Specialist guides include the Guide to the Suitability of Elastomeric Seal Materials, which is the subject of a separate paper in this conference, and the Guide to the Approval of Freight Containers as Types IP-2 and IP-3 Packages. This paper discusses the guidance material and summarises the administrative and technical information required in support of applications for approval of package designs, special form and low dispersible radioactive materials, shipments, special arrangements, modifications and validations.

  19. Worksite interventions for preventing physical deterioration among employees in job-groups with high physical work demands: Background, design and conceptual model of FINALE

    Directory of Open Access Journals (Sweden)

    Mortensen Ole S

    2010-03-01

    Full Text Available Abstract Background A mismatch between individual physical capacities and physical work demands enhance the risk for musculoskeletal disorders, poor work ability and sickness absence, termed physical deterioration. However, effective intervention strategies for preventing physical deterioration in job groups with high physical demands remains to be established. This paper describes the background, design and conceptual model of the FINALE programme, a framework for health promoting interventions at 4 Danish job groups (i.e. cleaners, health-care workers, construction workers and industrial workers characterized by high physical work demands, musculoskeletal disorders, poor work ability and sickness absence. Methods/Design A novel approach of the FINALE programme is that the interventions, i.e. 3 randomized controlled trials (RCT and 1 exploratory case-control study are tailored to the physical work demands, physical capacities and health profile of workers in each job-group. The RCT among cleaners, characterized by repetitive work tasks and musculoskeletal disorders, aims at making the cleaners less susceptible to musculoskeletal disorders by physical coordination training or cognitive behavioral theory based training (CBTr. Because health-care workers are reported to have high prevalence of overweight and heavy lifts, the aim of the RCT is long-term weight-loss by combined physical exercise training, CBTr and diet. Construction work, characterized by heavy lifting, pushing and pulling, the RCT aims at improving physical capacity and promoting musculoskeletal and cardiovascular health. At the industrial work-place characterized by repetitive work tasks, the intervention aims at reducing physical exertion and musculoskeletal disorders by combined physical exercise training, CBTr and participatory ergonomics. The overall aim of the FINALE programme is to improve the safety margin between individual resources (i.e. physical capacities, and

  20. 29 CFR 1952.164 - Final approval determination.

    Science.gov (United States)

    2010-07-01

    ... employment” within the meaning of the Migrant and Seasonal Agricultural Worker Protection Act, 29 U.S.C. 1802... Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION..., the Assistant Secretary determined that in operation, the State of Iowa occupational safety and...

  1. 29 CFR 1952.114 - Final approval determination.

    Science.gov (United States)

    2010-07-01

    ... “agricultural employment” within the meaning of the Migrant and Seasonal Agricultural Worker Protection Act, 29... Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... health program is at least as effective as the Federal program in providing safe and healthful...

  2. 29 CFR 1952.324 - Final approval determination.

    Science.gov (United States)

    2010-07-01

    ... meaning of the Migrant and Seasonal Agricultural Worker Protection Act, 29 U.S.C. 1802(3), regardless of... Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... occupational safety and health program is at least as effective as the Federal program in providing safe...

  3. 29 CFR 1952.204 - Final approval determination.

    Science.gov (United States)

    2010-07-01

    ... Migrant and Seasonal Agricultural Worker Protection Act, 29 U.S.C. 1802(3), regardless of the number of... Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... occupational safety and health program is at least as effective as the Federal program in providing safe...

  4. 29 CFR 1952.234 - Final approval determination.

    Science.gov (United States)

    2010-07-01

    ... Migrant and Seasonal Agricultural Worker Protection Act, 29 U.S.C. 1802(3), regardless of the number of... Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... occupational safety health program is at least as effective as the Federal program in providing safe...

  5. 29 CFR 1952.344 - Final approval determination.

    Science.gov (United States)

    2010-07-01

    ... the meaning of the Migrant and Seasonal Agricultural Worker Protection Act, 29 U.S.C. 1802(3... Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... occupational safety health program is at least as effective as the Federal program in providing safe...

  6. 29 CFR 1952.94 - Final approval determination.

    Science.gov (United States)

    2010-07-01

    ... Migrant and Seasonal Agricultural Worker Protection Act, 29 U.S.C. 1802(3), regardless of the number of... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... safety and health program is at least as effective as the Federal program in providing safe and...

  7. Obinutuzumab: first global approval.

    Science.gov (United States)

    Cameron, Fiona; McCormack, Paul L

    2014-01-01

    Obinutuzumab (Gazyva™) is an intravenously administered, humanized and glycoengineered, type II anti-CD20 monoclonal antibody for the treatment of B-cell malignancies. It is approved in the US for use in combination with chlorambucil for the first-line treatment of chronic lymphocytic leukaemia (CLL), and has been filed for approval in the EU in this indication. The antibody is based on GlycArt Biotechnology's (later Roche Glycart AG) proprietary GlycoMAb® technology, which uses glycoengineered antibodies that specifically increase antibody-dependent cellular cytotoxicity and thereby increase immune-mediated target cell death. Obinutuzumab is a type II anti-CD20 antibody that induces enhanced direct cell death. The monoclonal antibody is in worldwide phase III development with Roche and its subsidiaries, Genentech and Chugai Pharmaceutical, as well as Biogen Idec, for diffuse large B-cell lymphoma and non-Hodgkin's lymphoma generally, and is also in phase III development in countries outside of the US and EU for CLL.

  8. Safinamide: first global approval.

    Science.gov (United States)

    Deeks, Emma D

    2015-04-01

    Safinamide (Xadago(®)) is an oral α-aminoamide derivative developed by Newron for the treatment of Parkinson's disease (PD). The drug has both dopaminergic properties (highly selective and reversible inhibition of monoamine oxidase-B) and non-dopaminergic properties (selective sodium channel blockade and calcium channel modulation, with consequent inhibition of excessive glutamate release). Safinamide is approved in the EU, Iceland, Lichtenstein and Norway, as an add-on therapy to stable-dose levodopa, alone or in combination with other PD therapies in mid- to late-stage fluctuating PD patients; regulatory submissions have also been filed in the USA and Switzerland for its use in this indication. Additional submissions have been made in the USA, Iceland, Lichtenstein, Norway and Switzerland for early-stage PD. Safinamide has also undergone phase II investigation in PD patients with drug-induced dyskinesia (France, Germany, Austria, Canada and South Africa) or cognitive impairment (USA and Spain). This article summarizes the milestones in the development of safinamide leading to its first approval for PD.

  9. Fast Flux Test Facility final safety analysis report. Amendment 73

    Energy Technology Data Exchange (ETDEWEB)

    Gantt, D.A.

    1993-08-01

    This report provides Final Safety Analysis Report (FSAR) Amendment 73 for incorporation into the Fast Flux Test Facility (FFTR) FSAR set. This page change incorporates Engineering Change Notices (ECNs) issued subsequent to Amendment 72 and approved for incorparoration before May 6, 1993. These changes include: Chapter 3, design criteria structures, equipment, and systems; chapter 5B, reactor coolant system; chapter 7, instrumentation and control systems; chapter 9, auxiliary systems; chapter 11, reactor refueling system; chapter 12, radiation protection and waste management; chapter 13, conduct of operations; chapter 17, technical specifications; chapter 20, FFTF criticality specifications; appendix C, local fuel failure events; and appendix Fl, operation at 680{degrees}F inlet temperature.

  10. Fast Flux Test Facility final safety analysis report. Amendment 73

    Energy Technology Data Exchange (ETDEWEB)

    Gantt, D.A.

    1993-08-01

    This report provides Final Safety Analysis Report (FSAR) Amendment 73 for incorporation into the Fast Flux Test Facility (FFTR) FSAR set. This page change incorporates Engineering Change Notices (ECNs) issued subsequent to Amendment 72 and approved for incorparoration before May 6, 1993. These changes include: Chapter 3, design criteria structures, equipment, and systems; chapter 5B, reactor coolant system; chapter 7, instrumentation and control systems; chapter 9, auxiliary systems; chapter 11, reactor refueling system; chapter 12, radiation protection and waste management; chapter 13, conduct of operations; chapter 17, technical specifications; chapter 20, FFTF criticality specifications; appendix C, local fuel failure events; and appendix Fl, operation at 680{degrees}F inlet temperature.

  11. 9 CFR 381.133 - Generically approved labeling.

    Science.gov (United States)

    2010-01-01

    ... bearing pictorial designs, emblematic designs or illustrations, e.g., floral arrangements, illustrations of animals, fireworks, etc. are used with approved labeling (the use of such designs will not make...) Inserts, tags, liners, pasters, and like devices containing printed or graphic matter and for use on, or...

  12. Dental devices: classification of dental amalgam, reclassification of dental mercury, designation of special controls for dental amalgam, mercury, and amalgam alloy. Final rule.

    Science.gov (United States)

    2009-08-01

    The Food and Drug Administration (FDA) is issuing a final rule classifying dental amalgam into class II, reclassifying dental mercury from class I to class II, and designating a special control to support the class II classifications of these two devices, as well as the current class II classification of amalgam alloy. The three devices are now classified in a single regulation. The special control for the devices is a guidance document entitled, "Class II Special Controls Guidance Document: Dental Amalgam, Mercury, and Amalgam Alloy." This action is being taken to establish sufficient regulatory controls to provide reasonable assurance of the safety and effectiveness of these devices. Elsewhere in this issue of the Federal Register, FDA is announcing the availability of the guidance document that will serve as the special control for the devices.

  13. Drugs Approved for Cervical Cancer

    Science.gov (United States)

    ... Human Papillomavirus (HPV) Nonavalent Vaccine Recombinant Human Papillomavirus (HPV) Quadrivalent Vaccine Drugs Approved to Treat Cervical Cancer Avastin (Bevacizumab) Bevacizumab Blenoxane (Bleomycin) Bleomycin Hycamtin (Topotecan ...

  14. Optimization of the CLIC 500 GeV Final Focus system and design if a new 3 TeV Final Focus system with L*=6.0 M

    CERN Document Server

    Zamudio, Guillermo

    2010-01-01

    The optimization of the 500 GeV Final Focus System is presented for the conservative beam parameters. A Final Focus System for the nominal beam parameters is derived from the conservative lattice. A number of studies are presented for the 500 GeV Beam Delivery System. A new Final Focus System at 3 TeV with L*=6.0 m is presented and its performance is described.

  15. 基于GIS的户外广告审批系统的设计与实现%Design and Implementation of GIS-Based Outdoor Advertising Approval System

    Institute of Scientific and Technical Information of China (English)

    智升翠; 高洪主; 尤红

    2011-01-01

    "户外广告审报系统"引入了GIS技术用以户外广告的审批,实现了户外广告审批与管理的无纸化办公,提高了户外广告管理部门的工作效率,对"数字哈尔滨"建设具有深远意义。%"Outdoor advertising approval system" based on GIS technology is applied for approval of outdoor advertising.It achieved a paperless office for outdoor advertising approval and management,improved the work of outdoor advertising management efficiency,and had far-reaching significance for "Digital Harbin" construction.

  16. IER 203 CED-2 Report: LLNL Final Design for BERP Ball With a Composite Reflector of Thin Polyethylene Backed by Nickel

    Energy Technology Data Exchange (ETDEWEB)

    Percher, C. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Heinrichs, D. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kim, S. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-07-18

    This report documents the results of final design (CED-2) for IER 203, BERP Ball Composite Reflection, and focuses on critical configurations with a 4.5 kg α-phase plutonium sphere reflected by a combination of thin high-density polyethylene (HDPE) backed by a thick nickel reflector. The Lawrence Livermore National Laboratory’s (LLNL’s) Nuclear Criticality Safety Division, in support of fissile material operations, calculated surprisingly reactive configurations when a fissile core was surrounded by a thin, moderating reflector backed by a thick metal reflector. These composite reflector configurations were much more reactive than either of the single reflector materials separately. The calculated findings have resulted in a stricter-than-anticipated criticality control set, impacting programmatic work. IER 203 was requested in response to these seemingly anomalous calculations to see if the composite reflection effect could be shown experimentally. This report focuses on the Beryllium Reflected Plutonium (BERP) ball as a fissile material core reflected by polyethylene and nickel. A total of four critical configurations were designed as part of CED-2. Fabrication costs are estimated to be $98,500, largely due to the cost of the large nickel reflectors. The IER 203 experiments could reasonably be expected to begin in early FY2017.

  17. IER 203 CED-2 Report: LLNL Final Design for BERP Ball With a Composite Reflector of Thin Polyethylene Backed by Nickel

    Energy Technology Data Exchange (ETDEWEB)

    Percher, C. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Heinrichs, D. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Kim, S. K. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-07-18

    This report documents the results of final design (CED-2) for IER 203, BERP Ball Composite Reflection, and focuses on critical configurations with a 4.5 kg α-phase plutonium sphere reflected by a combination of thin high-density polyethylene (HDPE) backed by a thick nickel reflector. The Lawrence Livermore National Laboratory’s (LLNL’s) Nuclear Criticality Safety Division, in support of fissile material operations, calculated surprisingly reactive configurations when a fissile core was surrounded by a thin, moderating reflector backed by a thick metal reflector. These composite reflector configurations were much more reactive than either of the single reflector materials separately. The calculated findings have resulted in a stricter-than-anticipated criticality control set, impacting programmatic work. IER 203 was requested in response to these seemingly anomalous calculations to see if the composite reflection effect could be shown experimentally. This report focuses on the Beryllium Reflected Plutonium (BERP) ball as a fissile material core reflected by polyethylene and nickel. A total of four critical configurations were designed as part of CED-2. Fabrication costs are estimated to be $98,500, largely due to the cost of the large nickel reflectors. The IER 203 experiments could reasonably be expected to begin in early FY2017,

  18. Final focus test beam

    Energy Technology Data Exchange (ETDEWEB)

    1991-03-01

    This report discusses the following: the Final Focus Test Beam Project; optical design; magnets; instrumentation; magnetic measurement and BPM calibration; mechanical alignment and stabilization; vacuum system; power supplies; control system; radiation shielding and personnel protection; infrastructure; and administration.

  19. FDA-Approved HIV Medicines

    Science.gov (United States)

    HIV Treatment FDA-Approved HIV Medicines (Last updated 2/27/2017; last reviewed 2/27/2017) Treatment with HIV medicines is ... approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in the ...

  20. C-Band Airport Surface Communications System Standards Development. Phase II Final Report. Volume 1: Concepts of Use, Initial System Requirements, Architecture, and AeroMACS Design Considerations

    Science.gov (United States)

    Hall, Edward; Isaacs, James; Henriksen, Steve; Zelkin, Natalie

    2011-01-01

    This report is provided as part of ITT s NASA Glenn Research Center Aerospace Communication Systems Technical Support (ACSTS) contract NNC05CA85C, Task 7: New ATM Requirements-Future Communications, C-Band and L-Band Communications Standard Development and was based on direction provided by FAA project-level agreements for New ATM Requirements-Future Communications. Task 7 included two subtasks. Subtask 7-1 addressed C-band (5091- to 5150-MHz) airport surface data communications standards development, systems engineering, test bed and prototype development, and tests and demonstrations to establish operational capability for the Aeronautical Mobile Airport Communications System (AeroMACS). Subtask 7-2 focused on systems engineering and development support of the L-band digital aeronautical communications system (L-DACS). Subtask 7-1 consisted of two phases. Phase I included development of AeroMACS concepts of use, requirements, architecture, and initial high-level safety risk assessment. Phase II builds on Phase I results and is presented in two volumes. Volume I (this document) is devoted to concepts of use, system requirements, and architecture, including AeroMACS design considerations. Volume II describes an AeroMACS prototype evaluation and presents final AeroMACS recommendations. This report also describes airport categorization and channelization methodologies. The purposes of the airport categorization task were (1) to facilitate initial AeroMACS architecture designs and enable budgetary projections by creating a set of airport categories based on common airport characteristics and design objectives, and (2) to offer high-level guidance to potential AeroMACS technology and policy development sponsors and service providers. A channelization plan methodology was developed because a common global methodology is needed to assure seamless interoperability among diverse AeroMACS services potentially supplied by multiple service providers.

  1. Electronic Approval of Invoices (AEF)

    CERN Multimedia

    2004-01-01

    With a view to the simplification of administrative procedures, AS and FI Departments have completed the second phase of the new procedure for the electronic approval of invoices via the EDH application. The aim of this new procedure is to rationalise the invoice approval process, notably by eliminating paper copies from the approval circuit. This will simplify the processing of invoices and facilitate their timely settlement, while at the same time maintaining a high level of security. Phase II includes handling the electronic approval process of invoices whose amounts do not correspond exactly to those of the associated orders. In such cases, budgetary approval is required for the entire invoiced amount. Further information can be obtained at : http://ais.cern.ch/projs/AEF/help/F_help.htm Phase II of the procedure will be introduced gradually with effect from April 2004. Finance Department, Accounts Payable Section Tel: 72295 Organisation and Procedures Tel: 75885 Information Technologies Department,...

  2. 7 CFR 1737.90 - Loan approval requirements.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE PRE-LOAN POLICIES AND PROCEDURES COMMON TO INSURED AND GUARANTEED TELECOMMUNICATIONS LOANS Final... Disaster Protection Act of 1973, as amended (the “Flood Insurance Act”), RUS shall not approve financial... which has been identified by the Director of the Federal Emergency Management Agency (the “Director of...

  3. Biosimilars approval process.

    Science.gov (United States)

    Zuñiga, Leyre; Calvo, Begoña

    2010-04-01

    For similar biological medicinal products, the so-called biosimilars, clinical trials are required rather than just the bioequivalence studies required to support the registration of a generic small molecule drug product. The EU Directive 2001/83/EC, as amended, stated that where a biological medicinal product which is similar to a reference biological product, does not meet the conditions in the definition of generic medicinal products the results of appropriate pre-clinical tests or clinical trials relating to these conditions must be provided. The challenge is to determine the exact nature of the non-clinical and clinical programme required to gain regulatory approval. The applicant is encouraged to provide a detailed description of the strategy used to demonstrate the biosimilar and the reference product have similar profiles in terms of quality, safety and efficacy. The extent to which comparability can be proven will have quite an impact on how many non-clinical and clinical studies the biosimilar applicant will be required to conduct. The dossier submitted by the applicant to the EMEA should cover all aspects of the comparability assessment and must include data on possible unwanted immune reactions to the therapeutic protein. Post-marketing pharmacovigilance plans are also expected to be included in the biosimilar dossier.

  4. Design requirements to magnetic bearings for primary circuit blowers of high-temperature reactors. Final report; Auslegungsanforderungen an Magnetlager fuer Primaerkuehlgasgeblaese von Hochtemperaturreaktoren. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    1992-02-12

    To study the operational behaviour of blower shafts with magnetic bearings, a modular computer model was set up based on model laws, which permits to simulate shaft behaviour during dynamic loads acting on the blower shaft. During simulation runs, essential properties of position regulation (guide behaviour, secondary behaviour, and fault behaviour), and the behaviour of the blower shaft in the event of failure of a final stage of magnetic bearing electronics, with not-single-failure-proof and with failure-tolerant design of the final stages, as well as the effects of mechanical vibrations, e.g. as a result of earthquakes, on the behaviour of blower shafts were investigated. In order to transfer the results of the catch bearing tests to other designs of blowers with a vertical blower shaft, transmission laws and procedures were derived from theoretical considerations and from a dimension analysis which, however, could not be verified by means of tests. Application of the test results to horizontally placed blower shafts is possible only in part. The computer simulation model set up for the behaviour of the blower shafts is applicable without significant limitations to other blower shaft arrangements. (orig.). [Deutsch] Zur Untersuchung des Betriebsverhaltens magnetisch gelagerter Geblaesewellen wurde anhand von Modellgesetzen ein modulares Rechenmodell aufgebaut, das die Simulation des Wellenverhaltens bei auf die Geblaesewelle wirkenden dynamischen Belastungen erlaubt. In Simulationslaeufen wurden wesentliche Eigenschaften der Lageregelung (Fuehrungsverhalten, Folgeverhalten und Stoerungsverhalten) und das Verhalten der Geblaesewellen bei Ausfall einer Endstufe der Magnetlagerelektronik bei nicht einzelfehlersicherer und bei fehlertoleranter Ausfuehrung der Endstufen sowie die Auswirkungen mechanischer Erschuetterungen z.B. infolge von Erdbeben auf das Verhalten der Geblaesewelle untersucht. Zur Uebertragung der Ergebnisse der Fanglagerversuche auf andere

  5. 78 FR 73442 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; State Boards Requirements

    Science.gov (United States)

    2013-12-06

    ... not have any board or body which approves air quality permits or enforcement orders. The requirements... AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; Maryland; State Boards Requirements AGENCY: Environmental Protection Agency (EPA). ACTION: Direct final rule. SUMMARY...

  6. 78 FR 16412 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Consent Decree Requirements

    Science.gov (United States)

    2013-03-15

    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; Indiana; Consent Decree Requirements AGENCY: Environmental Protection Agency (EPA). ACTION: Direct final rule. SUMMARY... is also approving public notice requirements for these permit actions. These rules will help...

  7. 77 FR 15757 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2012-03-16

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling... Street NW., Washington, DC 20503. Final Approval Under OMB Delegated Authority of the Extension for Three...

  8. 77 FR 41405 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2012-07-13

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling... Street NW., Washington, DC 20503. Final approval under OMB delegated authority of the extension for three...

  9. 77 FR 74187 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2012-12-13

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling... Street NW., Washington, DC 20503. Final approval under OMB delegated authority the implementation of the...

  10. 78 FR 19264 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-03-29

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling... Street NW., Washington, DC 20503. Final approval under OMB delegated authority to revise the following...

  11. 77 FR 47841 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2012-08-10

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling... Street NW., Washington, DC 20503. Final approval under OMB delegated authority of the extension for three...

  12. 78 FR 77128 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-12-20

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, pursuant to 5 CFR 1320.16 (OMB Regulations on... Street NW., Washington, DC 20503. Final approval under OMB delegated authority the revision, without...

  13. 75 FR 71439 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-11-23

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as..., Washington, DC 20503. Final approval under OMB delegated authority of the extension for three years, with...

  14. 78 FR 50055 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-08-16

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling....,Washington, DC 20503. Final approval under OMB delegated authority of the extension for three years, with...

  15. 78 FR 6107 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-01-29

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Federal Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on... Street NW., Washington, DC 20503. Final approval under OMB delegated authority of the extension for three...

  16. 77 FR 60695 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2012-10-04

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling.... Final approval under OMB delegated authority of the extension for three years, with revision, of the...

  17. 78 FR 62016 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-10-11

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling....,Washington, DC 20503. Final approval under OMB delegated authority of the extension for three years, with...

  18. 76 FR 46807 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2011-08-03

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as..., New Executive Office Building, Room 10235, Washington, DC 20503. Final approval under OMB delegated...

  19. 75 FR 32468 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-06-08

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as.... Final approval under OMB delegated authority to discontinue the following report: Report title: Survey...

  20. 76 FR 29242 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2011-05-20

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collection by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as..., New Executive Office Building, Room 10235, Washington, DC 20503. Final approval under OMB delegated...

  1. 78 FR 42521 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-07-16

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling... Street NW., Washington, DC 20503. Final approval under OMB delegated authority of the extension for three...

  2. 75 FR 52529 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-08-26

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as.... Final approval under OMB delegated authority of the extension for three years, with revision, of the...

  3. 75 FR 55580 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-09-13

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as.... Final approval under OMB delegated authority of the extension for three years, without revision, of the...

  4. 75 FR 59263 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-09-27

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as.... Final approval under OMB delegated authority of the extension for three years, without revision, of the...

  5. 75 FR 19973 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-04-16

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as.... Final approval under OMB delegated authority of the extension for three years, without revision, of the...

  6. 75 FR 33807 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-06-15

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as.... Final approval under OMB delegated authority of the extension for three years, with revision, of the...

  7. 78 FR 6106 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-01-29

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling... Street NW.,Washington, DC 20503. Final approval under OMB delegated authority of the extension for three...

  8. 78 FR 21366 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-04-10

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Federal Reserve System (Board) under OMB delegated authority, per 5 CFR 1320.16 (OMB Regulations on... Street, NW.,Washington, DC 20503. Final approval under OMB delegated authority of the extension for three...

  9. 75 FR 81606 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-12-28

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as..., DC 20503. Final approval under OMB delegated authority of the extension for three years, without...

  10. 75 FR 18208 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-04-09

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as.... Final Approval Under OMB Delegated Authority of the Implementation of the Following Report Report title...

  11. 78 FR 61959 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-10-08

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling...., Washington, DC 20503. Final approval under OMB delegated authority of the extension for three years, with...

  12. 78 FR 59930 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-09-30

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling...., Washington, DC 20503. Final approval under OMB delegated authority of the implementation of the following...

  13. 78 FR 11646 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-02-19

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling... Street NW., Washington, DC 20503. Final approval under OMB delegated authority of the extension for three...

  14. 78 FR 38032 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2013-06-25

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling... Street NW., Washington, DC 20503. Final approval under OMB delegated authority of the extension for three...

  15. 77 FR 7578 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2012-02-13

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... Reserve System (Board) under OMB delegated authority, as per 5 CFR 1320.16 (OMB Regulations on Controlling... Street NW., Washington, DC 20503. Final approval under OMB delegated authority of the extension for three...

  16. 75 FR 66762 - Agency Information Collection Activities: Announcement of Board Approval Under Delegated...

    Science.gov (United States)

    2010-10-29

    ... Agency Information Collection Activities: Announcement of Board Approval Under Delegated Authority and... collections by the Board of Governors of the Federal Reserve System (Board) under OMB delegated authority, as..., DC 20503. Final Approval Under OMB Delegated Authority of the Extension for Three Years, Without...

  17. 77 FR 50576 - Fatigue Tolerance Evaluation of Metallic Structures; OMB Approval of Information Collection

    Science.gov (United States)

    2012-08-22

    ... Federal Aviation Administration 14 CFR Part 29 RIN 2120-AJ51 Fatigue Tolerance Evaluation of Metallic Structures; OMB Approval of Information Collection AGENCY: Federal Aviation Administration, DOT. ACTION: Final rule; OMB approval of information collection. SUMMARY: This document notifies the public of...

  18. 75 FR 68447 - Approval and Promulgation of Implementation Plans; Albuquerque/Bernalillo County, NM; Interstate...

    Science.gov (United States)

    2010-11-08

    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Implementation Plans; Albuquerque/ Bernalillo County, NM; Interstate Transport of Pollution AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: The EPA is approving a revision to the Albuquerque/Bernalillo County, New Mexico...

  19. 77 FR 58955 - Approval and Promulgation of Air Quality Implementation Plans; Commonwealth of Pennsylvania...

    Science.gov (United States)

    2012-09-25

    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; Commonwealth of... (EPA). ACTION: Final rule. SUMMARY: EPA is approving submittals from the Commonwealth of Pennsylvania... FR 54410), EPA published a notice of proposed rulemaking (NPR) for the Commonwealth of Pennsylvania...

  20. 75 FR 55988 - Approval and Promulgation of Implementation Plans; Commonwealth of Kentucky; Prevention of...

    Science.gov (United States)

    2010-09-15

    ... AGENCY 40 CFR Part 52 Approval and Promulgation of Implementation Plans; Commonwealth of Kentucky... final action to approve a revision to the Commonwealth of Kentucky's State Implementation Plan (SIP.... Background On February 5, 2010, the Commonwealth of Kentucky, through KDAQ, submitted a revision to the...