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  1. Uso de vitamina C en la solución tumescente de liposucción como inductor de lipolisis y fibrosis: Trabajo experimental Use of vitamine C in liposuction tumescent solution as lipolisis and fibrosis inductor: Experimental study

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    N. Antoniadis Petrakis

    2007-06-01

    Full Text Available La Liposucción no permite siempre extraer todo el tejido adiposo causante de la lipodistrofia, por lo cual se plantea la necesidad de perfeccionar esta técnica. Nuestro objetivo es el demostrar que el uso de la vitamina C en la solución tumescente induce lipólisis y aumenta la fibrosis. El presente es un estudio descriptivo, prospectivo, experimental y comparativo de una muestra de 30 ratas Sprague-Dawley de ambos sexos, a las cuales se les infiltró solución tumescente en el tejido subdérmico de la región inguinal, con vitamina C al grupo experimental y con solución tumescente sin vitamina C al grupo control, para su posterior estudio histológico macroscópico y microscópico. El 100% de las muestras con vitamina C evidenciaron cambios a nivel del tejido adiposo sugerentes de lipólisis y en el 82% se evidenciaron cambios en el tejido conectivo sugerentes de formación de colágeno joven. Concluimos que la vitamina C favorece la lipolisis y promueve la síntesis de colágeno cuando se utiliza como parte de la solución tumescente en animales de experimentaciónLiposuction does not always let to remove all the amount of adipose tissue which causes lipodistrophy, for that reason, it is recommended the necessity to improve that technique. We try to demonstrate that the use of vitamin C in the tumescence solution induces lipolysis and raises fibrosis. This article is a descriptive, prospective, experimental and comparative research of a sample of 30 mice of Sprague- Dawley type of both sexes, which were infiltrated with a tumescence solution in the subdermic inguinal region with vitamin C to the experimental group and with tumescence solution without vitamin C to the control group, for a further histological macroscopic as well as microscopic study. The results showed that 100% of the samples with vitamin C presented changes in the adipose tissue which suggested lipolysis, whereas 82% were evidence for the formation of young collagen. As a

  2. Experimental models of liver fibrosis.

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    Yanguas, Sara Crespo; Cogliati, Bruno; Willebrords, Joost; Maes, Michaël; Colle, Isabelle; van den Bossche, Bert; de Oliveira, Claudia Pinto Marques Souza; Andraus, Wellington; Alves, Venâncio Avancini Ferreira; Leclercq, Isabelle; Vinken, Mathieu

    2016-05-01

    Hepatic fibrosis is a wound healing response to insults and as such affects the entire world population. In industrialized countries, the main causes of liver fibrosis include alcohol abuse, chronic hepatitis virus infection and non-alcoholic steatohepatitis. A central event in liver fibrosis is the activation of hepatic stellate cells, which is triggered by a plethora of signaling pathways. Liver fibrosis can progress into more severe stages, known as cirrhosis, when liver acini are substituted by nodules, and further to hepatocellular carcinoma. Considerable efforts are currently devoted to liver fibrosis research, not only with the goal of further elucidating the molecular mechanisms that drive this disease, but equally in view of establishing effective diagnostic and therapeutic strategies. The present paper provides a state-of-the-art overview of in vivo and in vitro models used in the field of experimental liver fibrosis research.

  3. Noninvasive imaging of experimental lung fibrosis.

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    Zhou, Yong; Chen, Huaping; Ambalavanan, Namasivayam; Liu, Gang; Antony, Veena B; Ding, Qiang; Nath, Hrudaya; Eary, Janet F; Thannickal, Victor J

    2015-07-01

    Small animal models of lung fibrosis are essential for unraveling the molecular mechanisms underlying human fibrotic lung diseases; additionally, they are useful for preclinical testing of candidate antifibrotic agents. The current end-point measures of experimental lung fibrosis involve labor-intensive histological and biochemical analyses. These measures fail to account for dynamic changes in the disease process in individual animals and are limited by the need for large numbers of animals for longitudinal studies. The emergence of noninvasive imaging technologies provides exciting opportunities to image lung fibrosis in live animals as often as needed and to longitudinally track the efficacy of novel antifibrotic compounds. Data obtained by noninvasive imaging provide complementary information to histological and biochemical measurements. In addition, the use of noninvasive imaging in animal studies reduces animal usage, thus satisfying animal welfare concerns. In this article, we review these new imaging modalities with the potential for evaluation of lung fibrosis in small animal models. Such techniques include micro-computed tomography (micro-CT), magnetic resonance imaging, positron emission tomography (PET), single photon emission computed tomography (SPECT), and multimodal imaging systems including PET/CT and SPECT/CT. It is anticipated that noninvasive imaging will be increasingly used in animal models of fibrosis to gain insights into disease pathogenesis and as preclinical tools to assess drug efficacy.

  4. Effect of Ganfukang on liver function and serum hepatic fibrosis markers levels in SD rats with experimental hepatic fibrosis

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    Che Ying; Wang Shanju; Xu Tingting; Jiang Miaona; Jia Yujie

    2004-01-01

    Objective: To observe the effect of Ganfukang on liver function and serum hepatic fibrosis markers levels in SD rats with experimental hepatic fibrosis. Methods: SD rat models of liver fibrosis was induced by CCl 4 (n=57). Liver function (GPT, GOT) and serum hepatic fibrosis markers levels (HA, LN, C-IV, PC-III, with RIA) were tested in these models and 10 control rats. Eleven model rats were left untreated, the others were treated with Ganfukang of different concentrations and the above hepatic parameters were again determined after completion of treatment. Results: Lever function was much deteriorated and serum markers levels significantly increased in the model rats (vs controls, P<0.01). After treatment with Ganfukang, the improvement was significant (vs untreated models, P<0.01). Conclusion: Ganfukang is of definite therapeutic value for experimental hepatic fibrosis in rat models. (authors)

  5. Therapy of experimental NASH and fibrosis with galectin inhibitors.

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    Peter G Traber

    Full Text Available Non-alcoholic steatohepatitis (NASH and resultant liver fibrosis is a major health problem without effective therapy. Some data suggest that galectin-3 null mice are resistant to the development of NASH with fibrosis. We examined the ability of two complex carbohydrate drugs that bind galectin-3, GM-CT-01 and GR-MD-02, to treat NASH with fibrosis in a murine model. GR-MD-02 treatment resulted in marked improvement in liver histology with significant reduction in NASH activity and collagen deposition. Treatments seemed also to improve both glomerulopathy and interstitial fibrosis observed in kidneys. The improvement in liver histology was evident when animals were treated early in disease or after establishment of liver fibrosis. In all measures, GM-CT-01 had an intermediate effect between vehicle and GR-MD-02. Galectin-3 protein expression was increased in NASH with highest expression in macrophages surrounding lipid laden hepatocytes, and reduced following treatment with GR-MD-02, while the number of macrophages was unchanged. Treatment with GR-MD-02 also reduced the expression of pathological indicators including iNOS, an important TH1 inflammatory mediator, CD36, a scavenger receptor for lipoproteins on macrophages, and α-smooth muscle actin, a marker for activated stellate cells which are the primary collagen producing cells in liver fibrosis. We conclude that treatment with these galectin-3 targeting drugs improved histopathological findings of NASH and markedly reduced fibrosis in a murine model of NASH. While the mechanisms require further investigation, the treatment effect is associated with a reduction of galectin-3 expressed by activated macrophages which was associated with regression of NASH, including hepatocellular fat accumulation, hepatocyte ballooning, intra-portal and intra-lobular inflammatory infiltrate, and deposition of collagen. Similar effects were found with GM-CT-01, but with approximately four-fold lower potency than

  6. Experimental induction of pulmonary fibrosis in horses with the gammaherpesvirus equine herpesvirus 5.

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    Kurt J Williams

    Full Text Available Gammaherpesviruses (γHV are implicated in the pathogenesis of pulmonary fibrosis in humans and murine models of lung fibrosis, however there is little direct experimental evidence that such viruses induce lung fibrosis in the natural host. The equine γHV EHV 5 is associated with equine multinodular pulmonary fibrosis (EMPF, a progressive fibrosing lung disease in its natural host, the horse. Experimental reproduction of EMPF has not been attempted to date. We hypothesized that inoculation of EHV 5 isolated from cases of EMPF into the lungs of clinically normal horses would induce lung fibrosis similar to EMPF. Neutralizing antibody titers were measured in the horses before and after inoculation with EHV 5. PCR and virus isolation was used to detect EHV 5 in antemortem blood and BAL samples, and in tissues collected postmortem. Nodular pulmonary fibrosis and induction of myofibroblasts occurred in EHV 5 inoculated horses. Mean lung collagen in EHV 5 inoculated horses (80 µg/mg was significantly increased compared to control horses (26 µg/mg (p < 0.5, as was interstitial collagen (32.6% ± 1.2% vs 23% ± 1.4% (mean ± SEM; p < 0.001. Virus was difficult to detect in infected horses throughout the experiment, although EHV 5 antigen was detected in the lung by immunohistochemistry. We conclude that the γHV EHV 5 can induce lung fibrosis in the horse, and hypothesize that induction of fibrosis occurs while the virus is latent within the lung. This is the first example of a γHV inducing lung fibrosis in the natural host.

  7. Experimental induction of pulmonary fibrosis in horses with the gammaherpesvirus equine herpesvirus 5.

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    Williams, Kurt J; Robinson, N Edward; Lim, Ailam; Brandenberger, Christina; Maes, Roger; Behan, Ashley; Bolin, Steven R

    2013-01-01

    Gammaherpesviruses (γHV) are implicated in the pathogenesis of pulmonary fibrosis in humans and murine models of lung fibrosis, however there is little direct experimental evidence that such viruses induce lung fibrosis in the natural host. The equine γHV EHV 5 is associated with equine multinodular pulmonary fibrosis (EMPF), a progressive fibrosing lung disease in its natural host, the horse. Experimental reproduction of EMPF has not been attempted to date. We hypothesized that inoculation of EHV 5 isolated from cases of EMPF into the lungs of clinically normal horses would induce lung fibrosis similar to EMPF. Neutralizing antibody titers were measured in the horses before and after inoculation with EHV 5. PCR and virus isolation was used to detect EHV 5 in antemortem blood and BAL samples, and in tissues collected postmortem. Nodular pulmonary fibrosis and induction of myofibroblasts occurred in EHV 5 inoculated horses. Mean lung collagen in EHV 5 inoculated horses (80 µg/mg) was significantly increased compared to control horses (26 µg/mg) (p < 0.5), as was interstitial collagen (32.6% ± 1.2% vs 23% ± 1.4%) (mean ± SEM; p < 0.001). Virus was difficult to detect in infected horses throughout the experiment, although EHV 5 antigen was detected in the lung by immunohistochemistry. We conclude that the γHV EHV 5 can induce lung fibrosis in the horse, and hypothesize that induction of fibrosis occurs while the virus is latent within the lung. This is the first example of a γHV inducing lung fibrosis in the natural host.

  8. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models

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    Schnabl, Bernd; Farshchi-Heydari, Salman; Loomba, Rohit; Mattrey, Robert F.; Hoh, Carl K.; Sirlin, Claude B.; Brenner, David A.; Behling, Cynthia A.; Vera, David R.

    2016-01-01

    Objectives: The aim of this study was to test the ability of hepatocyte-specific functional imaging to stage fibrosis in experimental rat models of liver fibrosis and progressive NASH. Using ROC analysis we tested the ability of a functional imaging metric to discriminate early (F1) from moderate (F2) fibrosis in the absence and presence of non-alcoholic steatohepatitis, which has not been achieved by any modality other than biopsy. Methods: Galactosyl Human Serum Albumin (GSA) was radiolabeled with the positron-emitter, 68 Ga, and injected (i.v., 45–95 μCi, 1.5 pmol/g TBW) into 44 healthy, 19 DEN-, and 22 CDAA-treated male rats. Quantification of liver function was achieved by calculating T90, defined as the time for the liver to accumulate 90 percent of the [ 68 Ga]GSA plateau value. All livers were excised immediately after imaging and prepared for a “blinded” histologic examination, which included fibrosis and fat content scores. Two sets of fibrosis scores were recorded for all of animals. The dominant fibrosis stage was recorded as the “Dominant Pattern” score and the “Maximum Pattern” score was assigned if a smaller distinct region with a higher fibrosis score was observed. Results: Animals with Dominant Pattern F0–F1 liver fibrosis (D − = 39) demonstrated significantly (P < 0.0001) faster accumulation of [ 68 Ga]GSA (2.40 ± 0.52 min) than those with moderate to advanced Dominant Pattern fibrosis F2 and F4 (D + = 26) (3.48 ± 1.01 min). ROC analysis (F0–F1 vs F2–F4) produced an area under the binormal curve (AUC) of 0.867 ± 0.045. Twenty-seven of the 65 rats had small regions with higher fibrosis scores. Six of these Maximum Pattern scores reclassified the animals from D − to D + . ROC analysis of F0–F1 versus F2–F4 rats without liver fat produced AUCs of 0.881 ± 0.053 for the Dominant Pattern Score and 0.944 ± 0.035 for the Maximum Pattern Score. Conclusions: PET Functional Imaging of [ 68 Ga]GSA accurately discriminates

  9. Ethylenediaminetetraacetic acid induces antioxidant and anti-inflammatory activities in experimental liver fibrosis.

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    González-Cuevas, J; Navarro-Partida, J; Marquez-Aguirre, A L; Bueno-Topete, M R; Beas-Zarate, C; Armendáriz-Borunda, J

    2011-01-01

    Experimental liver fibrosis induced by carbon tetrachloride (CCl(4)) is associated with oxidative stress, lipid peroxidation, and inflammation. This work was focused on elucidating the anti-inflammatory and antioxidant effects of ethylenediaminetetraacetic acid (EDTA) in this model of hepatotoxicity. Wistar male rats were treated with CCl(4) and EDTA (60, 120, or 240 mg/kg). Morphometric analyses were carried out in Masson's stained liver sections to determine fibrosis index. Coagulation tests prothrombin time (PT) and partial thromboplastin time (PTT) were also determined. Gene expression for transforming growth factor beta (TGF-beta1), alpha1(I) procollagen gene (alpha1 Col I), tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and superoxide dismutase (SOD) was monitored by real-time PCR. Antioxidant effect of EDTA was measured by its effects on lipid peroxidation; biological activity of ceruloplasmin (Cp), SOD, and catalase (Cat) were analyzed by zymography assays. Animals with CCl(4)-hepatic injury that received EDTA showed a decrement in fibrosis (20%) and lipid peroxidation (22%). The mRNA expression for TNF-alpha (55%), TGF-beta1 (50%), IL-6 (52%), and alpha1 Col I (60%) was also decreased. This group of animals showed increased Cp (62%) and SOD (25%) biological activities. Coagulation blood tests, Cat activity, and gene expression for SOD were not modified by EDTA treatment. This study demonstrates that EDTA treatment induces the activity of antioxidant enzymes, decreases lipid peroxidation, hepatic inflammation, and fibrosis in experimental liver fibrosis induced by CCl(4).

  10. Application of metabonomics on an experimental model of fibrosis and cirrhosis induced by thioacetamide in rats

    International Nuclear Information System (INIS)

    Constantinou, Maria A.; Theocharis, Stamatios E.; Mikros, Emmanuel

    2007-01-01

    Metabonomics has already been used to discriminate different pathological states in biological fields. The metabolic profiles of chronic experimental fibrosis and cirrhosis induction in rats were investigated using 1 H NMR spectroscopy of liver extracts and serum combined with pattern recognition techniques. Rats were continuously administered with thioacetamide (TAA) in the drinking water (300 mg TAA/L), and sacrificed on 1st, 2nd, and 3rd month of treatment. 1 H NMR spectra of aqueous and lipid liver extracts, together with serum were subjected to Principal Component Analysis (PCA). Liver portions were also subjected to histopathological examination and biochemical determination of malondialdehyde (MDA). Liver fibrosis and cirrhosis were progressively induced in TAA-treated rats, verified by the histopathological examination and the alterations of MDA levels. TAA administration revealed a number of changes in the 1 H NMR spectra compared to control samples. The performance of PCA in liver extracts and serum, discriminated the control samples from the fibrotic and cirrhotic ones. Metabolic alterations revealed in NMR spectra during experimental liver fibrosis and cirrhosis induction, characterize the stage of fibrosis and could be illustrated by subsequent PCA of the spectra. Additionally, the PCA plots of the serum samples presented marked clustering during fibrosis progression and could be extended in clinical diagnosis for the management of cirrhotic patients

  11. Experimental liver fibrosis research: update on animal models, legal issues and translational aspects

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    2013-01-01

    Liver fibrosis is defined as excessive extracellular matrix deposition and is based on complex interactions between matrix-producing hepatic stellate cells and an abundance of liver-resident and infiltrating cells. Investigation of these processes requires in vitro and in vivo experimental work in animals. However, the use of animals in translational research will be increasingly challenged, at least in countries of the European Union, because of the adoption of new animal welfare rules in 2013. These rules will create an urgent need for optimized standard operating procedures regarding animal experimentation and improved international communication in the liver fibrosis community. This review gives an update on current animal models, techniques and underlying pathomechanisms with the aim of fostering a critical discussion of the limitations and potential of up-to-date animal experimentation. We discuss potential complications in experimental liver fibrosis and provide examples of how the findings of studies in which these models are used can be translated to human disease and therapy. In this review, we want to motivate the international community to design more standardized animal models which might help to address the legally requested replacement, refinement and reduction of animals in fibrosis research. PMID:24274743

  12. Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis

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    Joshi, Nikita; Kopec, Anna K.; Cline-Fedewa, Holly; Luyendyk, James P.

    2017-01-01

    The etiology of chronic bile duct injury and fibrosis in patients with autoimmune cholestatic liver diseases is complex, and likely involves immune cells such as lymphocytes. However, most models of biliary fibrosis are not autoimmune in nature. Biliary fibrosis can be induced experimentally by prolonged exposure of mice to the bile duct toxicant alpha-naphthylisothiocyanate (ANIT). We determined whether lymphocytes contributed to ANIT-mediated biliary hyperplasia and fibrosis in mice. Hepatic accumulation of T-lymphocytes and increased serum levels of anti-nuclear-autoantibodies were evident in wild-type mice exposed to ANIT (0.05% ANIT in chow). This occurred alongside bile duct hyperplasia and biliary fibrosis. To assess the role of lymphocytes in ANIT-induced biliary fibrosis, we utilized RAG1 −/− mice, which lack T- and B-lymphocytes. ANIT-induced bile duct injury, indicated by increased serum alkaline phosphatase activity, was reduced in ANIT-exposed RAG1 −/− mice compared to ANIT-exposed wild-type mice. Despite this reduction in biliary injury, ANIT-induced bile duct hyperplasia was similar in wild-type and RAG1 −/− mice. However, hepatic induction of profibrogenic genes including COL1A1, ITGβ6 and TGFβ2 was markedly attenuated in ANIT-exposed RAG1 −/− mice compared to ANIT-exposed wild-type mice. Peribiliary collagen deposition was also reduced in ANIT-exposed RAG1 −/− mice. The results indicate that lymphocytes exacerbate bile duct injury and fibrosis in ANIT-exposed mice without impacting bile duct hyperplasia.

  13. Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway

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    Zhang, Liang; Ji, Yunxia; Kang, Zechun; Lv, Changjun; Jiang, Wanglin

    2015-01-01

    An abnormal high mobility group box 1 (HMGB1) activation and a decrease in receptor for advanced glycation end-product (RAGE) play a key role in the pathogenesis of pulmonary fibrosis. Protocatechuic aldehyde (PA) is a naturally occurring compound, which is extracted from the degradation of phenolic acids. However, whether PA has anti-fibrotic functions is unknown. In this study, the effects of PA on the transforming growth factor-β1 (TGF-β1)-mediated epithelial–mesenchymal transition (EMT) in A549 cells, on the apoptosis of human type I alveolar epithelial cells (AT I), on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on bleomycin (BLM)-induced pulmonary fibrosis in vivo were investigated. PA treatment resulted in a reduction of EMT in A549 cells with a decrease in vimentin and HMGB, an increase of E-cadherin and RAGE, a reduction of HLF-1 proliferation with a decrease of fibroblast growth factor 2 (FGF-2) and platelet-derived growth factor (PDGF). Apoptosis of AT I was attenuated with an increase of RAGE. PA ameliorated BLM-induced pulmonary fibrosis in rats with a reduction of histopathological scores and collagen deposition, and a lower FGF-2, PDGF, α-smooth muscle actin (α-SMA) and HMGB1 expression, whereas higher RAGE was found in BLM-instilled lungs. Through the decrease of HGMB1 and the regulation of RAGE, PA reversed the EMT, inhibited HLF-1 proliferation as well as reduced apoptosis in AT I, and prevented pulmonary fibrosis in vivo. Collectively, our results demonstrate that PA prevents experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway. - Highlights: • PA prevents EMT, reduces the apoptosis of AT1 in vitro. • PA decreases proliferation of HLF-1, reduces PDGF and FGF expression in vitro. • PA prevents experimental pulmonary fibrosis by modulating the HMGB1/RAGE pathway

  14. Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway

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    Zhang, Liang, E-mail: countryspring@sina.com; Ji, Yunxia, E-mail: 413499057@qq.com; Kang, Zechun, E-mail: davidjiangwl@163.com; Lv, Changjun, E-mail: Lucky_lcj@sina.com; Jiang, Wanglin, E-mail: jwl518@163.com

    2015-02-15

    An abnormal high mobility group box 1 (HMGB1) activation and a decrease in receptor for advanced glycation end-product (RAGE) play a key role in the pathogenesis of pulmonary fibrosis. Protocatechuic aldehyde (PA) is a naturally occurring compound, which is extracted from the degradation of phenolic acids. However, whether PA has anti-fibrotic functions is unknown. In this study, the effects of PA on the transforming growth factor-β1 (TGF-β1)-mediated epithelial–mesenchymal transition (EMT) in A549 cells, on the apoptosis of human type I alveolar epithelial cells (AT I), on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on bleomycin (BLM)-induced pulmonary fibrosis in vivo were investigated. PA treatment resulted in a reduction of EMT in A549 cells with a decrease in vimentin and HMGB, an increase of E-cadherin and RAGE, a reduction of HLF-1 proliferation with a decrease of fibroblast growth factor 2 (FGF-2) and platelet-derived growth factor (PDGF). Apoptosis of AT I was attenuated with an increase of RAGE. PA ameliorated BLM-induced pulmonary fibrosis in rats with a reduction of histopathological scores and collagen deposition, and a lower FGF-2, PDGF, α-smooth muscle actin (α-SMA) and HMGB1 expression, whereas higher RAGE was found in BLM-instilled lungs. Through the decrease of HGMB1 and the regulation of RAGE, PA reversed the EMT, inhibited HLF-1 proliferation as well as reduced apoptosis in AT I, and prevented pulmonary fibrosis in vivo. Collectively, our results demonstrate that PA prevents experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway. - Highlights: • PA prevents EMT, reduces the apoptosis of AT1 in vitro. • PA decreases proliferation of HLF-1, reduces PDGF and FGF expression in vitro. • PA prevents experimental pulmonary fibrosis by modulating the HMGB1/RAGE pathway.

  15. Protective roles of pulmonary rehabilitation mixture in experimental pulmonary fibrosis in vitro and in vivo

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    Zhang, L.; Ji, Y.X.; Jiang, W.L.; Lv, C.J.

    2015-01-01

    Abnormal high mobility group protein B1 (HMGB1) activation is involved in the pathogenesis of pulmonary fibrosis. Pulmonary rehabilitation mixture (PRM), which combines extracts from eight traditional Chinese medicines, has very good lung protection in clinical use. However, it is not known if PRM has anti-fibrotic activity. In this study, we investigated the effects of PRM on transforming growth factor-β1 (TGF-β1)-mediated and bleomycin (BLM)-induced pulmonary fibrosis in vitro and in vivo. The effects of PRM on TGF-β1-mediated epithelial-mesenchymal transition (EMT) in A549 cells, on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on BLM-induced pulmonary fibrosis in vivo were investigated. PRM treatment resulted in a reduction of EMT in A549 cells that was associated with attenuating an increase of vimentin and a decrease of E-cadherin. PRM inhibited the proliferation of HLF-1 at an IC 50 of 0.51 µg/mL. PRM ameliorated BLM-induced pulmonary fibrosis in rats, with reduction of histopathological scores and collagen deposition, and a decrease in α-smooth muscle actin (α-SMA) and HMGB1 expression. An increase in receptor for advanced glycation end-product (RAGE) expression was found in BLM-instilled lungs. PRM significantly decreased EMT and prevented pulmonary fibrosis through decreasing HMGB1 and regulating RAGE in vitro and in vivo. PRM inhibited TGF-β1-induced EMT via decreased HMGB1 and vimentin and increased RAGE and E-cadherin levels. In summary, PRM prevented experimental pulmonary fibrosis by modulating the HMGB1/RAGE pathway

  16. Protective roles of pulmonary rehabilitation mixture in experimental pulmonary fibrosis in vitro and in vivo

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    Zhang, L.; Ji, Y.X.; Jiang, W.L.; Lv, C.J. [School of Pharmaceutical Sciences, Binzhou Medical University, Yantai (China)

    2015-05-08

    Abnormal high mobility group protein B1 (HMGB1) activation is involved in the pathogenesis of pulmonary fibrosis. Pulmonary rehabilitation mixture (PRM), which combines extracts from eight traditional Chinese medicines, has very good lung protection in clinical use. However, it is not known if PRM has anti-fibrotic activity. In this study, we investigated the effects of PRM on transforming growth factor-β1 (TGF-β1)-mediated and bleomycin (BLM)-induced pulmonary fibrosis in vitro and in vivo. The effects of PRM on TGF-β1-mediated epithelial-mesenchymal transition (EMT) in A549 cells, on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on BLM-induced pulmonary fibrosis in vivo were investigated. PRM treatment resulted in a reduction of EMT in A549 cells that was associated with attenuating an increase of vimentin and a decrease of E-cadherin. PRM inhibited the proliferation of HLF-1 at an IC{sub 50} of 0.51 µg/mL. PRM ameliorated BLM-induced pulmonary fibrosis in rats, with reduction of histopathological scores and collagen deposition, and a decrease in α-smooth muscle actin (α-SMA) and HMGB1 expression. An increase in receptor for advanced glycation end-product (RAGE) expression was found in BLM-instilled lungs. PRM significantly decreased EMT and prevented pulmonary fibrosis through decreasing HMGB1 and regulating RAGE in vitro and in vivo. PRM inhibited TGF-β1-induced EMT via decreased HMGB1 and vimentin and increased RAGE and E-cadherin levels. In summary, PRM prevented experimental pulmonary fibrosis by modulating the HMGB1/RAGE pathway.

  17. Oxidized low-density-lipoprotein accumulation is associated with liver fibrosis in experimental cholestasis

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    Güldeniz Karadeniz

    2008-01-01

    Full Text Available OBJECTIVE: The aim of the present study was to examine the probable relationship between the accumulation of oxLDL and hepatic fibrogenesis in cholestatic rats. INTRODUCTION: There is growing evidence to support the current theories on how oxidative stress that results in lipid peroxidation is involved in the pathogenesis of cholestatic liver injury and fibrogenesis. One of the major and early lipid peroxidation products, OxLDL, is thought to play complex roles in various immuno-inflammatory mechanisms. METHODS: A prolonged (21-day experimental bile duct ligation was performed on Wistar-albino rats. Biochemical analysis of blood, histopathologic evaluation of liver, measurement of the concentration of malondialdehyde (MDA and superoxide-dismutase (SOD in liver tissue homogenates, and immunofluorescent staining for oxLDL in liver tissue was conducted in bile-duct ligated (n = 8 and sham-operated rats (n = 8. RESULTS: Significantly higher levels of MDA and lower concentrations of SOD were detected in jaundiced rats than in the sham-operated rats. Positive oxLDL staining was also observed in liver tissue sections of jaundiced rats. Histopathological examination demonstrated that neither fibrosis nor other indications of hepatocellular injury were found in the sham-operated group, while features of severe hepatocellular injury, particularly fibrosis, were found in jaundiced rats. CONCLUSION: Our results support the finding that either oxLDLs are produced as an intermediate agent during exacerbated oxidative stress or they otherwise contribute to the various pathomechanisms underlying the process of liver fibrosis. Whatever the mechanism, it is clear that an association exists between elevated oxLDL levels and hepatocellular injury, particularly with fibrosis. Further studies are needed to evaluate the potential effects of oxLDLs on the progression of secondary biliary cirrhosis.

  18. Genetic Deletion of Soluble Epoxide Hydrolase Attenuates Inflammation and Fibrosis in Experimental Obstructive Nephropathy

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    Chin-Wei Chiang

    2015-01-01

    Full Text Available Soluble epoxide hydrolase (sEH is abundantly expressed in kidney and plays a potent role in regulating inflammatory response in inflammatory diseases. However, the role of sEH in progression of chronic kidney diseases such as obstructive nephropathy is still elusive. In current study, wild-type (WT and sEH deficient (sEH−/− mice were subjected to the unilateral ureteral obstruction (UUO surgery and the kidney injury was evaluated by histological examination, western blotting, and ELISA. The protein level of sEH in kidney was increased in UUO-treated mice group compared to nonobstructed group. Additionally, UUO-induced hydronephrosis, renal tubular injury, inflammation, and fibrosis were ameliorated in sEH−/− mice with the exception of glomerulosclerosis. Moreover, sEH−/− mice with UUO showed lower levels of inflammation-related and fibrosis-related protein such as monocyte chemoattractant protein-1, macrophage inflammatory protein-2, interleukin-1β (IL-1β, IL-6, inducible nitric oxide synthase, collagen 1A1, and α-actin. The levels of superoxide anion radical and hydrogen peroxide as well as NADPH oxidase activity were also decreased in UUO kidneys of sEH−/− mice compared to that observed in WT mice. Collectively, our findings suggest that sEH plays an important role in the pathogenesis of experimental obstructive nephropathy and may be a therapeutic target for the treatment of obstructive nephropathy-related diseases.

  19. Experimental pulmonary fibrosis in rats with chronic gastric acid reflux esophagitis.

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    Shimazu, Rintaro; Aoki, Shigehisa; Kuratomi, Yuichiro

    2015-10-01

    To elucidate the association between gastric acid reflux and respiratory diseases by studying the histological changes of the lower airway in rats with chronic acid reflux esophagitis. An experimental rat model of chronic acid reflux esophagitis was surgically created. The lower airways of these rats were histologically observed for more than 50 weeks. Although there were no histological changes which induced gastric acid reflux at 10 weeks after surgery, thickening of the basal laminae and the proliferation of the collagenous fibers were observed in the alveolar epithelium at 20 weeks after surgery. At 50 weeks after surgery, the collagenous fibers obliterated the pulmonary alveoli and bronchial lumen. These findings observed in the GERD rats are similar to the pathological findings of human pulmonary fibrosis. In this study, we reported pathological changes in the lower airways of GERD rat models observed for more than 50 weeks. These results suggest that gastric acid reflux may be one of the pathogenic or exacerbating factors of pulmonary fibrosis. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  20. Simultaneous Administration of ADSCs-Based Therapy and Gene Therapy Using Ad-huPA Reduces Experimental Liver Fibrosis.

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    Meza-Ríos, Alejandra; García-Benavides, Leonel; García-Bañuelos, Jesus; Salazar-Montes, Adriana; Armendáriz-Borunda, Juan; Sandoval-Rodríguez, Ana

    2016-01-01

    hADSCs transplantation in cirrhosis models improves liver function and reduces fibrosis. In addition, Ad-huPA gene therapy diminished fibrosis and increased hepatocyte regeneration. In this study, we evaluate the combination of these therapies in an advanced liver fibrosis experimental model. hADSCs were expanded and characterized before transplantation. Ad-huPA was simultaneously administrated via the ileac vein. Animals were immunosuppressed by CsA 24 h before treatment and until sacrifice at 10 days post-treatment. huPA liver expression and hADSCs biodistribution were evaluated, as well as the percentage of fibrotic tissue, hepatic mRNA levels of Col-αI, TGF-β1, CTGF, α-SMA, PAI-I, MMP2 and serum levels of ALT, AST and albumin. hADSCs homed mainly in liver, whereas huPA expression was similar in Ad-huPA and hADSCs/Ad-huPA groups. hADSCs, Ad-huPA and hADSCs/Ad-huPA treatment improves albumin levels, reduces liver fibrosis and diminishes Collagen α1, CTGF and α-SMA mRNA liver levels. ALT and AST serum levels showed a significant decrease exclusively in the hADSCs group. These results showed that combinatorial effect of cell and gene-therapy does not improve the antifibrogenic effects of individual treatments, whereas hADSCs transplantation seems to reduce liver fibrosis in a greater proportion.

  1. JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study.

    Science.gov (United States)

    Milara, Javier; Ballester, Beatriz; Morell, Anselm; Ortiz, José L; Escrivá, Juan; Fernández, Estrella; Perez-Vizcaino, Francisco; Cogolludo, Angel; Pastor, Enrique; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio

    2018-06-01

    Pulmonary hypertension (PH) is a common disorder in patients with idiopathic pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators approved for PH have failed in improving IPF mainly due to ventilation ( V )/perfusion ( Q ) mismatching and oxygen desaturation. Janus kinase type 2 (JAK2) is a non-receptor tyrosine kinase activated by a broad spectrum of profibrotic and vasoactive mediators, but its role in PH associated to PH is unknown. The study of JAK2 as potential target to treat PH in IPF. JAK2 expression was increased in pulmonary arteries (PAs) from IPF (n=10; 1.93-fold; P=0.0011) and IPF+PH (n=9; 2.65-fold; Ppulmonary artery endothelial cells (HPAECs) and human pulmonary artery smooth muscle cells (HPASMCs) from patients with IPF in vitro treated with the JAK2 inhibitor JSI-124 or siRNA-JAK2 and stimulated with transforming growth factor beta. Both JSI-124 and siRNA-JAK2 inhibited the HPAEC to mesenchymal transition and the HPASMCs to myofibroblast transition and proliferation. JAK2 inhibition induced small PA relaxation in precision-cut lung slice experiments. PA relaxation was dependent of the large conductance calcium-activated potassium channel (BK Ca ). JAK2 inhibition activated BK Ca channels and reduced intracellular Ca 2+ . JSI-124 1 mg/kg/day, reduced bleomycin-induced lung fibrosis, PA remodelling, right ventricular hypertrophy, PA hypertension and V / Q mismatching in rats. The animal studies followed the ARRIVE guidelines. JAK2 participates in PA remodelling and tension and may be an attractive target to treat IPF associated to PH. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  2. The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis.

    Science.gov (United States)

    Kurowska-Stolarska, Mariola; Hasoo, Manhl K; Welsh, David J; Stewart, Lynn; McIntyre, Donna; Morton, Brian E; Johnstone, Steven; Miller, Ashley M; Asquith, Darren L; Millar, Neal L; Millar, Ann B; Feghali-Bostwick, Carol A; Hirani, Nikhil; Crick, Peter J; Wang, Yuqin; Griffiths, William J; McInnes, Iain B; McSharry, Charles

    2017-06-01

    Idiopathic pulmonary fibrosis (IPF) is progressive and rapidly fatal. Improved understanding of pathogenesis is required to prosper novel therapeutics. Epigenetic changes contribute to IPF; therefore, microRNAs may reveal novel pathogenic pathways. We sought to determine the regulatory role of microRNA (miR)-155 in the profibrotic function of murine lung macrophages and fibroblasts, IPF lung fibroblasts, and its contribution to experimental pulmonary fibrosis. Bleomycin-induced lung fibrosis in wild-type and miR-155 -/- mice was analyzed by histology, collagen, and profibrotic gene expression. Mechanisms were identified by in silico and molecular approaches and validated in mouse lung fibroblasts and macrophages, and in IPF lung fibroblasts, using loss-and-gain of function assays, and in vivo using specific inhibitors. miR-155 -/- mice developed exacerbated lung fibrosis, increased collagen deposition, collagen 1 and 3 mRNA expression, TGF-β production, and activation of alternatively activated macrophages, contributed by deregulation of the miR-155 target gene the liver X receptor (LXR)α in lung fibroblasts and macrophages. Inhibition of LXRα in experimental lung fibrosis and in IPF lung fibroblasts reduced the exacerbated fibrotic response. Similarly, enforced expression of miR-155 reduced the profibrotic phenotype of IPF and miR-155 -/- fibroblasts. We describe herein a molecular pathway comprising miR-155 and its epigenetic LXRα target that when deregulated enables pathogenic pulmonary fibrosis. Manipulation of the miR-155/LXR pathway may have therapeutic potential for IPF. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  3. B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis.

    Science.gov (United States)

    François, Antoine; Gombault, Aurélie; Villeret, Bérengère; Alsaleh, Ghada; Fanny, Manoussa; Gasse, Paméla; Adam, Sylvain Marchand; Crestani, Bruno; Sibilia, Jean; Schneider, Pascal; Bahram, Seiamak; Quesniaux, Valérie; Ryffel, Bernhard; Wachsmann, Dominique; Gottenberg, Jacques-Eric; Couillin, Isabelle

    2015-01-01

    Idiopathic pulmonary fibrosis (IPF) is a progressive devastating, yet untreatable fibrotic disease of unknown origin. We investigated the contribution of the B-cell activating factor (BAFF), a TNF family member recently implicated in the regulation of pathogenic IL-17-producing cells in autoimmune diseases. The contribution of BAFF was assessed in a murine model of lung fibrosis induced by airway administered bleomycin. We show that murine BAFF levels were strongly increased in the bronchoalveolar space and lungs after bleomycin exposure. We identified Gr1(+) neutrophils as an important source of BAFF upon BLM-induced lung inflammation and fibrosis. Genetic ablation of BAFF or BAFF neutralization by a soluble receptor significantly attenuated pulmonary fibrosis and IL-1β levels. We further demonstrate that bleomycin-induced BAFF expression and lung fibrosis were IL-1β and IL-17A dependent. BAFF was required for rIL-17A-induced lung fibrosis and augmented IL-17A production by CD3(+) T cells from murine fibrotic lungs ex vivo. Finally we report elevated levels of BAFF in bronchoalveolar lavages from IPF patients. Our data therefore support a role for BAFF in the establishment of pulmonary fibrosis and a crosstalk between IL-1β, BAFF and IL-17A. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Modulation of CD11c+ lung dendritic cells in respect to TGF-β in experimental pulmonary fibrosis.

    Science.gov (United States)

    Chakraborty, Kaustav; Chatterjee, Soumya; Bhattacharyya, Arindam

    2017-09-01

    Idiopathic pulmonary fibrosis (IPF) is a deadly, progressive lung disease with very few treatment options till now. Bleomycin-induced pulmonary fibrosis (BIPF) is a commonly used mice model in IPF research. TGF-β1 has been shown to play a key role in pulmonary fibrosis (PF). Dendritic cell (DC) acts as a bridge between innate and adaptive immune systems. The coexistence of chronic inflammation sustained by mature DCs with fibrosis suggests that inflammatory phenomenon has key importance in the pathogenesis of pulmonary fibrosis. Here, we investigated the modulation of DCs phenotypic maturation, accumulation in lung tissue, and expression of other lung DC subsets in respect to TGF-β in PF. First, we established BIPF model in mice and blocked TGF-β expression by the use of inhibitor SB431542. Accumulation of lung CD11c+ DCs is significantly higher in both inflammatory and fibrotic phases of the disease but that percentages got reduced in the absence of TGF-β. TGF-β initiates up-regulation of costimulatory molecules CD86 and CD80 in the inflammatory phases of the disease but not so at fibrotic stage. Expression of lung DC subset CD11c+CD103+ is significantly increased in inflammatory phase and also in fibrotic phase of BIPF. Blocking of TGF-β causes decreased expression of CD11c+CD103+ DCs. Another important lung DC subset CD11c+CD11b+ expression is suppressed by the absence of TGF-β after bleomycin administration. CD11c+CD103+ DCs might have anti-inflammatory as well as anti-fibrotic nature in PF. All these data demonstrate differential modulation of CD11c+ lung DCs by TGF-β in experimental PF. © 2017 International Federation for Cell Biology.

  5. Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis

    DEFF Research Database (Denmark)

    Moser, Claus; van Gennip, Maria; Bjarnsholt, Thomas

    2009-01-01

    Moser C, van Gennip M, Bjarnsholt T, Jensen PO, Lee B, Hougen HP, Calum H, Ciofu O, Givskov M, Molin S, Hoiby N. Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis. APMIS 2009; 117: 95-107. The dominant cause of premature...... death in patients suffering from cystic fibrosis (CF) is chronic lung infection with Pseudomonas aeruginosa. The chronic lung infection often lasts for decades with just one clone. However, as a result of inflammation, antibiotic treatment and different niches in the lungs, the clone undergoes...... and 2003) of the chronic lung infection of one CF patient using the seaweed alginate embedment model. The results showed that the non-mucoid clones reduced their virulence over time, resulting in faster clearing of the bacteria from the lungs, improved pathology and reduced pulmonary production...

  6. IL-10 is significantly involved in HSP70-regulation of experimental subretinal fibrosis.

    Directory of Open Access Journals (Sweden)

    Yang Yang

    Full Text Available Subretinal fibrosis is directly related to severe visual loss, especially if occurs in the macula, and is frequently observed in advanced age-related macular degeneration and other refractory eye disorders such as diabetic retinopathy and uveitis. In this study, we analyzed the immunosuppressive mechanism of subretinal fibrosis using the novel animal model recently demonstrated. Both TLR2 and TLR4 deficient mice showed significant enlargement of subretinal fibrotic area as compared with wild-type mice. A single intraocular administration of heat shock protein 70 (HSP70, which is an endogenous ligand for TLR2 and TLR4, inhibited subretinal fibrosis in wild-type mice but not in TLR2 and TLR4-deficient mice. Additionally, HSP70 induced IL-10 production in eyes from wild-type mice but was impaired in both TLR2- and TLR4-deficient mice, indicating that HSP70-TLR2/TLR4 axis plays an immunomodulatory role in subretinal fibrosis. Thus, these results suggest that HSP70-TLR2/TLR4 axis is a new therapeutic target for subretinal fibrosis due to prognostic CNV.

  7. Role of IL-1β in experimental cystic fibrosis upon P. aeruginosa infection.

    Directory of Open Access Journals (Sweden)

    Jennifer Palomo

    Full Text Available Cystic fibrosis is associated with increased inflammatory responses to pathogen challenge. Here we revisited the role of IL-1β in lung pathology using the experimental F508del-CFTR murine model on C57BL/6 genetic background (Cftr(tm1eur or d/d, on double deficient for d/d and type 1 interleukin-1 receptor (d/d X IL-1R1-/-, and antibody neutralization. At steady state, young adult d/d mice did not show any signs of spontaneous lung inflammation. However, IL-1R1 deficiency conferred partial protection to repeated P. aeruginosa endotoxins/LPS lung instillation in d/d mice, as 50% of d/d mice succumbed to inflammation, whereas all d/d x IL-1R1-/- double mutants survived with lower initial weight loss and less pulmonary collagen and mucus production, suggesting that the absence of IL-1R1 signaling is protective in d/d mice in LPS-induced lung damage. Using P. aeruginosa acute lung infection we found heightened neutrophil recruitment in d/d mice with higher epithelial damage, increased bacterial load in BALF, and augmented IL-1β and TNF-α in parenchyma as compared to WT mice. Thus, F508del-CFTR mice show enhanced IL-1β signaling in response to P. aeruginosa. IL-1β antibody neutralization had no effect on lung homeostasis in either d/d or WT mice, however P. aeruginosa induced lung inflammation and bacterial load were diminished by IL-1β antibody neutralization. In conclusion, enhanced susceptibility to P. aeruginosa in d/d mice correlates with an excessive inflammation and with increased IL-1β production and reduced bacterial clearance. Further, we show that neutralization of IL-1β in d/d mice through the double mutation d/d x IL-1R1-/- and in WT via antibody neutralization attenuates inflammation. This supports the notion that intervention in the IL-1R1/IL-1β pathway may be detrimental in CF patients.

  8. Experimental study of CT perfusion in hepatitis, hepatic fibrosis and early stage of cirrhosis

    International Nuclear Information System (INIS)

    Guan Sheng; Zhao Weidong; Zhou Kangrong; Peng Weijun; Mao Jian; Tang Feng; Wang Yong; Cao Guang; Sun Fei

    2005-01-01

    Objective: To investigate the value of CT perfusion in the early diagnosis of hepatic diffuse disease. Methods: Fourteen male Wistar rats of control group and 14 of test group at stages of hepatitis, hepatic fibrosis, hepatic cirrhosis which were induced with diethylnitrosamine (DEN), were studied with CT perfusion respectively. CT perfusion data of different stages were compared and pathologic analysis were performed. Results: Density-time curves of CT perfusion were satisfactory and all perfusion data could be obtained. During the period of hepatitis developing into early stage of hepatic cirrhosis, hepatic artery flow (HAF) trended to increase in test group, mean transmit time (MTT) prolonged obviously, blood flow (BF) and volume (BV) declined. While in control group, HAF declined slightly, MTT, BV and BF increased. Statistic analysis showed the differences of HAF and MTT at different stages between control and test groups were significant (P<0.05 ); the differences of BV and BF between hepatitis and hepatic cirrhosis, hepatic fibrosis and early stage of hepatic cirrhosis in test group were significant (P<0.05), but no significant difference between hepatitis and hepatic fibrosis. The corresponding pathologic changes at stage of hepatitis was swelling of hepatic cells; sinusoids cap illarization and deposition of collagen in the extravascular Disse's spaces were the main changes relating to hepatic blood perfusion at stage of fibrosis and early stage of cirrhosis. Conclusion: The method of CT scan can reflect some changes of hepatic blood perfusion in rats with hepatitis, hepatic fibrosis and early stage of cirrhosis. The data of CT perfusion, especially the changes should be valuable for clinical early diagnosis, treatment and follow-up. (authors)

  9. Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension.

    Science.gov (United States)

    Avouac, Jerome; Konstantinova, Irena; Guignabert, Christophe; Pezet, Sonia; Sadoine, Jeremy; Guilbert, Thomas; Cauvet, Anne; Tu, Ly; Luccarini, Jean-Michel; Junien, Jean-Louis; Broqua, Pierre; Allanore, Yannick

    2017-11-01

    To evaluate the antifibrotic effects of the pan-peroxisome proliferator-activated receptor (PPAR) agonist IVA337 in preclinical mouse models of pulmonary fibrosis and related pulmonary hypertension (PH). IVA337 has been evaluated in the mouse model of bleomycin-induced pulmonary fibrosis and in Fra-2 transgenic mice, this latter being characterised by non-specific interstitial pneumonia and severe vascular remodelling of pulmonary arteries leading to PH. Mice received two doses of IVA337 (30 mg/kg or 100 mg/kg) or vehicle administered by daily oral gavage up to 4 weeks. IVA337 demonstrated at a dose of 100 mg/kg a marked protection from the development of lung fibrosis in both mouse models compared with mice receiving 30 mg/kg of IVA337 or vehicle. Histological score was markedly reduced by 61% in the bleomycin model and by 50% in Fra-2 transgenic mice, and total lung hydroxyproline concentrations decreased by 28% and 48%, respectively, as compared with vehicle-treated mice. IVA337 at 100 mg/kg also significantly decreased levels of fibrogenic markers in lesional lungs of both mouse models. In addition, IVA337 substantially alleviated PH in Fra-2 transgenic mice by improving haemodynamic measurements and vascular remodelling. In primary human lung fibroblasts, IVA337 inhibited in a dose-dependent manner fibroblast to myofibroblasts transition induced by TGF-β and fibroblast proliferation mediated by PDGF. We demonstrate that treatment with 100 mg/kg IVA337 prevents lung fibrosis in two complementary animal models and substantially attenuates PH in the Fra-2 mouse model. These findings confirm that the pan-PPAR agonist IVA337 is an appealing therapeutic candidate for these cardiopulmonary involvements. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  10. An experimental study on carcinogenesis related to localized fibrosis in the lung

    International Nuclear Information System (INIS)

    Ohwada, Hidemi; Hayashi, Yutaka; Seki, Masatoshi.

    1980-01-01

    The present series of experiments was carried out in order to see what role pre-existing localized fibrosis plays in carcinogenesis of the lung. Hemorrhagic infarction was produced in the lung of 180 male Wistar rats by injecting 0.05 ml of hexachlorotetrafluorobutane into the tail vein. This resulted in localized fibrosis in the lung 3 months later. One hundred and fifteen rats were alive 3 months after administration of the chemical. Of these animals, 30 were given no further treatment (control). The remaining 85 rats were given intratracheal instillation of 0.2 μCi of polonium-210 once a week, a total of 15 times. It was subsequently found that lung carcinoma was induced in close proximity to the localized pulmonary fibrosis in 3 of 26 rats (11.5%) during the period from completion of the 15 weekly administrations of polonium-210 until the end of this experiment (21 months after the 1st instillation of polonium-210). Polonium-210 was found to be deposited in the fibrous thickening of the alveolus around the subpleural fibrotic lesion, bronchial epithelium, and peribronchial lymph apparati at the initial period of administration of polonium-210, but during the period of pulmonary carcinogenesis, it was deposited in the localized fibrotic lesion in the lung and in a few cancer cells. This suggests that polonium-210 deposited in the pulmonary fibrotic lesion remains there over a long period of time, indicating a reduced clearance ability at this site. (author)

  11. Protective role of gambogic acid in experimental pulmonary fibrosis in vitro and in vivo.

    Science.gov (United States)

    Qu, Yubei; Zhang, Guanghua; Ji, Yunxia; Zhua, Haibo; Lv, Changjun; Jiang, Wanglin

    2016-04-15

    Idiopathic pulmonary fibrosis (IPF) is a progressive disorder with poor prognosis. The treatment options for IPF are very limited. Gambogic acid (GA) has anticancer effect and anti-proliferative activity which is extracted from a dried yellow resin of the Garcinia hanburyi Hook.f. [Clusiaceae (Guttiferae)] in Southeast Asia. However, the anti-fibrotic activities of GA have not been previously investigated. In this study, the effects of GA on TGF-β1-mediated epithelial-mesenchymal transition (EMT) in A549 cells and endothelial-mesenchymal transition (EndoMT) in human pulmonary microvascular endothelial cells (HPMECs), on the proliferation of human lung fibroblasts (HLF-1) were investigated in vitro, and on bleomycin (BLM)-induced pulmonary fibrosis was investigated in vivo. In TGF-β1 stimulated A549 cells, treatment with GA resulted in a reduction of EMT with a decrease in vimentin and p-Smad3 and an increase in E-cadherin instead. In TGF-β1 stimulated HPMECs, treatment with GA resulted in a reduction of EndoMT with a decrease in vimentin, and an increase in VE-cadherin instead. In the hypoxic HPMECs, treatment with GA reduced Vasohibin-2 (VASH-2), whereas increased VASH-1. In TGF-β1 stimulated HLF-1, treatment with GA reduced HLF-1 proliferation with a decrease in platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF-2) expressions. In vivo, treatment with GA for 2 weeks resulted in an amelioration of the BLM-induced pulmonary fibrosis in rats with a lower VASH-2. Instead, it was observed a higher VASH-1 expression at early stage of fibrosis at 1 mg/kg, with reductions of the pathological score, collagen deposition, α-SMA, PDGF and FGF-2 expressions at fibrotic stage at 0.5 mg/kg and 1 mg/kg. In summary, GA reversed EMT and EndoMT, as well as HLF-1 proliferation in vitro and prevented pulmonary fibrosis in vivo by modulating VASH-2/VASH-1 and suppressing the TGF-β1/Smad3 pathway. Copyright © 2016 Elsevier GmbH. All rights reserved.

  12. Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: an experimental study.

    Science.gov (United States)

    Lefaix, J L; Delanian, S; Leplat, J J; Tricaud, Y; Martin, M; Nimrod, A; Baillet, F; Daburon, F

    1996-05-01

    To establish how far liposomal copper/zinc superoxide dismutase (Cu/Zn-SOD) and manganese superoxide dismutase (Mn-SOD), respectively, reduce radiation-induced fibrosis (RIF), using a well-characterized pig model of RIF permitting the design of a controlled laboratory experiment. In this model of acute localized gamma irradiation simulating accidental overexposure in humans, three groups of five large white pigs were irradiated using a collimated 192Ir source to deliver a single dose of 160 Gy onto the skin surface (100%) of the outer side of the thigh. A well-defined block of subcutaneous fibrosis involving skin and skeletal muscle developed 6 months after irradiation. One experimental group of five pigs was then injected i.m. with 10 mg/10 kg b.wt. of Cu/Zn-SOD, twice a week for 3 weeks, and another experimental group of five was injected with 10 mg/10 kg b.wt. of Mn-SOD, three times a week for 3 weeks. Five irradiated control pigs were injected with physiological serum. Animals were assessed for changes in the density of the palpated fibrotic block and in the dimensions of the projected cutaneous surface. Block depth was determined by ultrasound. Physical and sonographic findings were confirmed by autopsy 12-14 weeks after completing SOD injections. The density, length, width, and depth of the fibrotic block, and the areas and volume of its projected cutaneous surface were compared before treatment, 1, 3, and 6 weeks thereafter, and at autopsy, 12-14 weeks after treatment ended. The experimental animals exhibited no change in behavior and no abnormal clinical or anatomic signs. Whether they were given Cu/Zn- or Mn-SOD, significant and roughly equivalent softening and shrinking of the fibrotic block were noted in all treated animals between the first week after treatment ended and autopsy, when mean regression was 45% for length and width, 30% for depth, and 70% for area and volume. Histologic examination showed completely normal muscle and subcutaneous tissue

  13. Dried Human Amniotic Membrane Does Not Alleviate Inflammation and Fibrosis in Experimental Strabismus Surgery

    Directory of Open Access Journals (Sweden)

    Bo Young Chun

    2013-01-01

    Full Text Available Purpose. The purpose of this study was to evaluate the efficacy of dried human amniotic membrane (AM in reducing the postoperative inflammatory response and scarring after strabismus surgery. Methods. The inflammatory response at the extraocular muscle reattachment site was analyzed after superior rectus (SR resection in 12 rabbits. Dried human AM (Ambiodry2 was applied between the resected SR muscle plane and Tenon’s capsule of the left eyes of rabbits. As a control, the right eyes of rabbits underwent SR resection only. The surgeon randomly ordered which eye gets operated first during the experiment. Two weeks later, enucleation was performed. Six sagittal sections were made for each eye at the insertion of the SR muscle. The grade of postoperative inflammation and the presence of fibrosis were evaluated in histological examinations. Results. There was no statistically significant difference in the intensity of inflammation and fibrous proliferation between the eyes treated with dried human AM after SR resection and those treated with SR resection only. Conclusions. The use of dried human AM was not effective in controlling the postoperative inflammation and scarring in rabbit eyes after extraocular muscle surgery. However, this may be due to the devitalized dry preparation of human AM (Ambiodry2, which may have lost the expected anti-inflammatory and anti-scarring properties, and further studies on humans may be necessary.

  14. Modeling pulmonary fibrosis by abnormal expression of telomerase/apoptosis/collagen V in experimental usual interstitial pneumonia

    International Nuclear Information System (INIS)

    Parra, E.R.; Pincelli, M.S.; Teodoro, W.R.; Velosa, A.P.P.; Martins, V.; Rangel, M.P.; Barbas-Filho, J.V.; Capelozzi, V.L.

    2014-01-01

    Limitations on tissue proliferation capacity determined by telomerase/apoptosis balance have been implicated in pathogenesis of idiopathic pulmonary fibrosis. In addition, collagen V shows promise as an inductor of apoptosis. We evaluated the quantitative relationship between the telomerase/apoptosis index, collagen V synthesis, and epithelial/fibroblast replication in mice exposed to butylated hydroxytoluene (BHT) at high oxygen concentration. Two groups of mice were analyzed: 20 mice received BHT, and 10 control mice received corn oil. Telomerase expression, apoptosis, collagen I, III, and V fibers, and hydroxyproline were evaluated by immunohistochemistry, in situ detection of apoptosis, electron microscopy, immunofluorescence, and histomorphometry. Electron microscopy confirmed the presence of increased alveolar epithelial cells type 1 (AEC1) in apoptosis. Immunostaining showed increased nuclear expression of telomerase in AEC type 2 (AEC2) between normal and chronic scarring areas of usual interstitial pneumonia (UIP). Control lungs and normal areas from UIP lungs showed weak green birefringence of type I and III collagens in the alveolar wall and type V collagen in the basement membrane of alveolar capillaries. The increase in collagen V was greater than collagens I and III in scarring areas of UIP. A significant direct association was found between collagen V and AEC2 apoptosis. We concluded that telomerase, collagen V fiber density, and apoptosis evaluation in experimental UIP offers the potential to control reepithelization of alveolar septa and fibroblast proliferation. Strategies aimed at preventing high rates of collagen V synthesis, or local responses to high rates of cell apoptosis, may have a significant impact in pulmonary fibrosis

  15. Modeling pulmonary fibrosis by abnormal expression of telomerase/apoptosis/collagen V in experimental usual interstitial pneumonia

    Energy Technology Data Exchange (ETDEWEB)

    Parra, E.R.; Pincelli, M.S. [Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Teodoro, W.R.; Velosa, A.P.P. [Disciplina de Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Martins, V.; Rangel, M.P.; Barbas-Filho, J.V.; Capelozzi, V.L. [Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

    2014-06-04

    Limitations on tissue proliferation capacity determined by telomerase/apoptosis balance have been implicated in pathogenesis of idiopathic pulmonary fibrosis. In addition, collagen V shows promise as an inductor of apoptosis. We evaluated the quantitative relationship between the telomerase/apoptosis index, collagen V synthesis, and epithelial/fibroblast replication in mice exposed to butylated hydroxytoluene (BHT) at high oxygen concentration. Two groups of mice were analyzed: 20 mice received BHT, and 10 control mice received corn oil. Telomerase expression, apoptosis, collagen I, III, and V fibers, and hydroxyproline were evaluated by immunohistochemistry, in situ detection of apoptosis, electron microscopy, immunofluorescence, and histomorphometry. Electron microscopy confirmed the presence of increased alveolar epithelial cells type 1 (AEC1) in apoptosis. Immunostaining showed increased nuclear expression of telomerase in AEC type 2 (AEC2) between normal and chronic scarring areas of usual interstitial pneumonia (UIP). Control lungs and normal areas from UIP lungs showed weak green birefringence of type I and III collagens in the alveolar wall and type V collagen in the basement membrane of alveolar capillaries. The increase in collagen V was greater than collagens I and III in scarring areas of UIP. A significant direct association was found between collagen V and AEC2 apoptosis. We concluded that telomerase, collagen V fiber density, and apoptosis evaluation in experimental UIP offers the potential to control reepithelization of alveolar septa and fibroblast proliferation. Strategies aimed at preventing high rates of collagen V synthesis, or local responses to high rates of cell apoptosis, may have a significant impact in pulmonary fibrosis.

  16. A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats.

    Science.gov (United States)

    Wang, Ning; Feng, Yibin; Cheung, Fan; Chow, Oi-Yee; Wang, Xuanbin; Su, Weiwei; Tong, Yao

    2012-11-29

    Bear bile and Coptidis Rhizoma have been used in Chinese medicine with a long tradition in treating heat-diseases. Both bear bile and Coptidis Rhizoma are used to treat liver diseases in clinical practice of Chinese Medicine. Since bears are currently endangered, it raises the question whether the use of bear bile is ethical. To look for substitute for bear bile, the aim of this study is to compare the anti-fibrotic effects of Coptidis Rhizoma and its major component berberine with the actions of bear bile and its major compound tauroursodeoxycholic acid on experimental liver fibrosis in rats. Quality assessment was conducted with high performance liquid chromatography. The experimental liver fibrosis in rats was induced by carbon tetrachloride, alcohol, and bile duct ligation respectively. The biochemical criteria in the blood and tissue samples were measured to evaluate the anti-fibrotic properties and underlying mechanisms of the drugs. Coptidis Rhizoma Aqueous Extract (CRAE), berberine, and bear bile exerted anti-fibrotic properties on various liver fibrosis models in rats. CRAE and berberine significantly reduced the peroxidative stress in liver through increasing the superoxide dismutase enzyme activity. CRAE and berberine were able to excrete bilirubin products from the liver and protect hepatocytes from cholestatic damage. The effect of CRAE and berberine are comparable to that of bear bile. Instead of using bear bile, CRAE and berberine can be potential substitutes in treating liver fibrosis.

  17. Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid

    Directory of Open Access Journals (Sweden)

    Li Chun-jun

    2012-06-01

    Full Text Available Abstract Background Alpha-lipoic acid (ALA, a naturally occurring compound, exerts powerful protective effects in various cardiovascular disease models. However, its role in protecting against diabetic cardiomyopathy (DCM has not been elucidated. In this study, we have investigated the effects of ALA on cardiac dysfunction, mitochondrial oxidative stress (MOS, extracellular matrix (ECM remodeling and interrelated signaling pathways in a diabetic rat model. Methods Diabetes was induced in rats by I.V. injection of streptozotocin (STZ at 45 mg/kg. The animals were randomly divided into 4 groups: normal groups with or without ALA treatment, and diabetes groups with or without ALA treatment. All studies were carried out 11 weeks after induction of diabetes. Cardiac catheterization was performed to evaluate cardiac function. Mitochondrial oxidative biochemical parameters were measured by spectophotometeric assays. Extracellular matrix content (total collagen, type I and III collagen was assessed by staining with Sirius Red. Gelatinolytic activity of Pro- and active matrix metalloproteinase-2 (MMP-2 levels were analyzed by a zymogram. Cardiac fibroblasts differentiation to myofibroblasts was evaluated by Western blot measuring smooth muscle actin (α-SMA and transforming growth factor–β (TGF-β. Key components of underlying signaling pathways including the phosphorylation of c-Jun N-terminal kinase (JNK, p38 MAPK and ERK were also assayed by Western blot. Results DCM was successfully induced by the injection of STZ as evidenced by abnormal heart mass and cardiac function, as well as the imbalance of ECM homeostasis. After administration of ALA, left ventricular dysfunction greatly improved; interstitial fibrosis also notably ameliorated indicated by decreased collagen deposition, ECM synthesis as well as enhanced ECM degradation. To further assess the underlying mechanism of improved DCM by ALA, redox status and cardiac remodeling associated

  18. Collagen crosslink location: a molecular marker for fibrosis in lungs of rats with experimental silicosis

    International Nuclear Information System (INIS)

    Gerriets, J.E.; Reiser, K.M.; Last, J.A.

    1986-01-01

    Collagen content is increased in lungs of animals with experimental silicosis. They hypothesize that the collagen deposited in such fibrotic lungs differs structurally from normal lung collagen. Silicotic lung collagen shows an increase in lysine hydroxylation. In addition, the ratio of the difunctional crosslinks DHLNL (dihydroxylysinonorleucine) to HLNL (hydroxylysinonorleucine) is sharply elevated compared to that in control lungs. The peptide α1(I)CB7 x α2(I)CB1 crosslinked by HLNL was demonstrated in NaB 3 H 4 -reduced, CNBr-digested collagen from rat tail tendon by peptide purification, followed by periodate oxidation and amino acid analysis. Further structural analysis of this peptide was obtained by digestion of the crosslinked peptide with trypsin and purification of the tryptic peptide containing this crosslink followed by amino acid analysis. They then examined the analogous collagenous peptide in normal and silicotic lungs and analyzed the crosslink it contained. They observed that DHLNL was present at specific sites previously containing HLNL; that is, the collagen in fibrotic lungs is altered at specific sites by post-translational modification of a lysine residue by hydroxylation in a predictable way. They conclude that such unusual hydroxylation of a specific lysine residue in the α2 chain provides a molecular marker for fibrotic lung collagen

  19. Introduction to Pulmonary Fibrosis

    Science.gov (United States)

    ... page: Introduction to Pulmonary Fibrosis What Is Pulmonary Fibrosis? Pulmonary fibrosis is a disease where there is scarring ... of pulmonary fibrosis. Learn more How Is Pulmonary Fibrosis Diagnosed? Pulmonary fibrosis can be difficult to diagnose, so it ...

  20. Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis.

    Science.gov (United States)

    El-Mezayen, Nesrine S; El-Hadidy, Wessam F; El-Refaie, Wessam M; Shalaby, Th I; Khattab, Mahmoud M; El-Khatib, Aiman S

    2017-11-28

    Liver fibrosis is a global health problem without approved treatment. Imatinib inhibits two key profibrotic pathways; platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-β) and thus can be used to treat liver fibrosis. However, conventional imatinib therapy is hampered by low concentration at target tissue and increased toxicity to other tissues especially heart, lung and liver. Since hepatic stellate cells (HSCs) are the main contributors to liver fibrosis pathogenesis and sole hepatic vitamin A (V A ) storage cells, they can be actively targeted by coupling liposomes to V A . In this study, novel V A -coupled imatinib-loaded liposomes (ILC) were prepared and optimized regarding V A -coupling efficiency, imatinib entrapment efficiency, and particle size. Preferential accumulation of the selected formula in liver was proved by tracing intraperitoneally (i.p.)-injected V A -coupled liposomes loaded with Nile Red (LCNR) to rats with CCl 4 -induced liver fibrosis using live animal imaging. Co-localization of LCNR with immunofluorescently-labeled PDGFR-β in frozen liver tissue sections confirmed HSCs targeting. ILC bio-distribution, following single i.p. injection, revealed 13.5 folds higher hepatic accumulation than conventional imatinib in addition to limited bio-distribution to other organs including heart and lung reflecting diminished adverse effects. ILC therapy resulted in a potent inhibition of phosphorylated PDGFR-β expression when compared to conventional imatinib. Subsequently, there was a statistically significant improvement in liver function tests and reversal of hepatotoxicity along with liver fibrosis. Anti-fibrotic effect was evident from histopathologic Ishak score reduction as well as normalization of the level of profibrotic mediators (hydroxyproline, TGF-B and matrix metalloproteinase-2). Thus, HSC-targeted imatinib therapy shows outstanding anti-fibrotic effects with reduced cytotoxicity compared to conventional

  1. Empresas de trabajo temporal

    OpenAIRE

    Chico Abad, Virginia

    2015-01-01

    Las empresas de trabajo temporal han ido tomando mayor relevancia debido a la estructura de la sociedad y de la economía. La entrada en vigor de la ley 14/1994 por la que se regulan las empresas de trabajo temporal suposo la incorporación al ordenamiento jurífico español de un tipo de empresas cuya actuación se habia extendido en otros países del entorno europeo. La idea general gira en torno a la flexibilidad de un nuevo marco económico y organizativo y exige a las empresas una capa...

  2. FELICIDAD EN EL TRABAJO

    OpenAIRE

    Salvatore Moccia

    2016-01-01

    Uno de los principales objetivos de la psicología del trabajo y de las organizaciones es promover tanto el bienestar como el rendimiento de los empleados. Sin embargo, los distintos autores nos son unánimes respectos a los fundamentos de la felicidad. El objetivo de este trabajo es presentar las enormes contribuciones de la Psicología Positiva y de la Filosofía al tema de la felicidad y sus influencias en el ámbito organizativo y de la productividad, ofreciendo una revisión de los distintos a...

  3. Diccionario de Trabajo Social

    Directory of Open Access Journals (Sweden)

    Octavio Vásquez Aguado

    2014-03-01

    Full Text Available La realización de un diccionario de Trabajo Social, como el que reseñamos aquí, constituye un esfuerzo intelectual de primera magnitud en el que un número importante de académicos y profesionales vinculados a la disciplina participan con el objetivo de contribuir, decididamente, a la consolidación de una terminología en torno a los conceptos claves, las teorías, los modelos, los referentes históricos fundamentales, que han configurado y definen al Trabajo Social como profesión y disciplina.

  4. El trabajo en equipo

    OpenAIRE

    Brugarolas, A. (A.)

    1992-01-01

    Este es el último punto del manuscrito, que inesperadamente ha cobrado vida y se ha trasladado a la introducción, y es que el trabajo en equipo se ha convertido en un trabajo que busca equipo. Por este motivo, tras denunciar al autor, solicita encontrar un equipo que lo corrija, incremente, modifique e ilumine. Inmediatamente he pensado en posibles candidatos, que propondré al primero que acepte formar equipo, para dar cumplida satisfacción a un texto que ha salido reivindicativo y fiel a sí ...

  5. Silymarin and caffeine combination ameliorates experimentally-induced hepatic fibrosis through down-regulation of LPAR1 expression.

    Science.gov (United States)

    Eraky, Salma M; El-Mesery, Mohamed; El-Karef, Amro; Eissa, Laila A; El-Gayar, Amal M

    2018-05-01

    Lysophosphatidic acid is a lipid mediator that is supposed to be implicated in hepatic fibrosis. Silymarin and caffeine are natural compounds known for their anti-inflammatory and antioxidant effects. Our study aimed to explore the effect of silymarin, caffeine, and their combination on lysophosphatidic acid receptor 1 (LPAR1) pathway in thioacetamide (TAA)-induced hepatic fibrosis. Hepatic fibrosis was induced in male Sprague-Dawley rats by intraperitoneal injection of 200 mg/kg of TAA twice a week for 8 weeks. Silymarin (50 mg/kg), caffeine (50 mg/kg), and their combination (50 mg/kg silymarin + 50 mg/kg caffeine) were orally given to rats every day for 8 weeks along with TAA injection. Liver functions were measured. Histopathological examination of liver tissues was performed using hematoxylin and eosin and Masson's trichrome staining. mRNA expressions of LPAR1, transforming growth factor beta 1 (TGF-β1), connective tissue growth factor (CTGF), and alpha smooth muscle actin (α-SMA) were measured using RT-PCR. LPAR1 tissue expression was scored using immunohistochemistry. Silymarin, caffeine, and their combination significantly improved liver function. They caused significant decrease in fibrosis and necro-inflammatory scores. Combination of silymain and caffeine caused a significant decrease in the necro-inflammatory score than the single treatment with silymarin or caffeine. In addition, silymarin, caffeine, and their combination significantly decreased hepatic LPAR1, TGF-β1, CTGF, and α-SMA gene expressions and LPAR1 tissue expression. Silymarin, caffeine, and their combination protect against liver fibrosis through down-regulation of LPAR1, TGF-β1, and CTGF. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  6. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) increases necroinflammation and hepatic stellate cell activation but does not exacerbate experimental liver fibrosis in mice

    Energy Technology Data Exchange (ETDEWEB)

    Lamb, Cheri L.; Cholico, Giovan N. [Biomolecular Sciences Graduate Program, Boise State University, Boise, ID 83725 (United States); Pu, Xinzhu [Biomolecular Research Center, Boise State University, Boise, ID 83725 (United States); Hagler, Gerald D. [Department of Biological Sciences, Boise State University, Boise, ID 83725 (United States); Cornell, Kenneth A. [Biomolecular Sciences Graduate Program, Boise State University, Boise, ID 83725 (United States); Biomolecular Research Center, Boise State University, Boise, ID 83725 (United States); Department of Chemistry and Biochemistry, Boise State University, Boise, ID 83725 (United States); Mitchell, Kristen A., E-mail: kristenmitchell@boisestate.edu [Biomolecular Sciences Graduate Program, Boise State University, Boise, ID 83725 (United States); Department of Biological Sciences, Boise State University, Boise, ID 83725 (United States)

    2016-11-15

    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant and high-affinity ligand for the aryl hydrocarbon receptor (AhR). Increasing evidence indicates that AhR signaling contributes to wound healing, which involves the coordinated deposition and remodeling of the extracellular matrix. In the liver, wound healing is attributed to the activation of hepatic stellate cells (HSCs), which mediate fibrogenesis through the production of soluble mediators and collagen type I. We recently reported that TCDD treatment increases the activation of human HSCs in vitro. The goal of this study was to determine how TCDD impacts HSC activation in vivo using a mouse model of experimental liver fibrosis. To elicit fibrosis, C57BL6/male mice were treated twice weekly for 8 weeks with 0.5 ml/kg carbon tetrachloride (CCl{sub 4}). TCDD (20 μg/kg) or peanut oil (vehicle) was administered once a week during the last 2 weeks. Results indicate that TCDD increased liver-body-weight ratios, serum alanine aminotransferase activity, and hepatic necroinflammation in CCl{sub 4}-treated mice. Likewise, TCDD treatment increased mRNA expression of HSC activation and fibrogenesis genes, namely α-smooth muscle actin, desmin, delta-like homolog-1, TGF-β1, and collagen type I. However, TCDD treatment did not exacerbate fibrosis, nor did it increase the collagen content of the liver. Instead, TCDD increased hepatic collagenase activity and increased expression of matrix metalloproteinase (MMP)-13 and the matrix regulatory proteins, TIMP-1 and PAI-1. These results support the conclusion that TCDD increases CCl{sub 4}-induced liver damage and exacerbates HSC activation, yet collagen deposition and the development of fibrosis may be limited by TCDD-mediated changes in extracellular matrix remodeling. - Highlights: • TCDD increased liver damage and inflammation in mice treated with CCl{sub 4}. • TCDD treatment enhanced markers of hepatic stellate cell activation and

  7. Symbiotic formulation in experimentally induced liver fibrosis in rats: intestinal microbiota as a key point to treat liver damage?

    Science.gov (United States)

    D'Argenio, Giuseppe; Cariello, Rita; Tuccillo, Concetta; Mazzone, Giovanna; Federico, Alessandro; Funaro, Annalisa; De Magistris, Laura; Grossi, Enzo; Callegari, Maria L; Chirico, Marilena; Caporaso, Nicola; Romano, Marco; Morelli, Lorenzo; Loguercio, Carmela

    2013-05-01

    Evidence indicates that intestinal microbiota may participate in both the induction and the progression of liver damage. The aim of our research was the detection and evaluation of the effects of chronic treatment with a symbiotic formulation on CCl4 -induced rat liver fibrosis. CCl4 significantly increased gastric permeability in respect to basal values, and the treatment with symbiotic significantly decreased it. CCl4 per se induced a decrease in intestinal permeability. This effect was also seen in fibrotic rats treated with symbiotic and was still evident when normal rats were treated with symbiotic alone (P symbiotic treatment normalized the plasma levels of TNF-α and significantly enhanced anti-inflammatory cytokine IL 10. TNF-α, TGF-β, TLR4, TLR2, iNOS and α-SMA mRNA expression in the liver were up-regulated in rats with CCl4 -induced liver fibrosis and down-regulated by symbiotic treatment. Moreover, IL-10 and eNOS mRNA levels were increased in the CCL4 (+) symbiotic group. Symbiotic treatment of fibrotic rats normalized serum ALT, AST and improved histology and liver collagen deposition. DGGE analysis of faecal samples revealed that CCl4 administration and symbiotic treatment either alone or in combination produced modifications in faecal profiles vs controls. Our results provide evidence that in CCl4 -induced liver fibrosis, significant changes in gastro-intestinal permeability and in faecal flora occur. Treatment with a specific symbiotic formulation significantly affects these changes, leading to improvement in both liver inflammation and fibrosis. © 2013 John Wiley & Sons A/S.

  8. emergencia del trabajo liberado

    Directory of Open Access Journals (Sweden)

    Rocío Gómez Z.

    2008-01-01

    Full Text Available Este ensayo sugiere que habría una inestimable conexión entre el compromiso subjetivo y emocional de los jóvenes usuarios de Internet, que invierten tiempo y deseo en realizar un conjunto variado de obras menores (correos electrónicos, imágenes de sí mismos en Facebook, trozos de música, mantenimiento de la bitácora en la Red, y los malestares del bienestar urbano. Estas obras menores encarnan y objetivan las demandas de trabajo liberado -frecuentemente reprimidas, pospuestas, administradas o reguladas-, que algunos de los nuevos repertorios tecnológicos canalizan y movilizan vigorosamente.

  9. Múltiples campos de trabajo

    OpenAIRE

    Despos, Pablo

    2016-01-01

    Este trabajo que se enmarca y vincula con la práctica profesional del periodista deportivo y en los desafíos de la profesión en el siglo XXI. Aquí se reflexionará y argumentará sobre los avatares que implica las diferentes labores periodísticas en torno a un proyecto de periodismo gráfico autogestionado como la revista Indios Quilmes y su participación en las redes sociales.

  10. FELICIDAD EN EL TRABAJO

    Directory of Open Access Journals (Sweden)

    Salvatore Moccia

    2016-05-01

    Full Text Available Uno de los principales objetivos de la psicología del trabajo y de las organizaciones es promover tanto el bienestar como el rendimiento de los empleados. Sin embargo, los distintos autores nos son unánimes respectos a los fundamentos de la felicidad. El objetivo de este trabajo es presentar las enormes contribuciones de la Psicología Positiva y de la Filosofía al tema de la felicidad y sus influencias en el ámbito organizativo y de la productividad, ofreciendo una revisión de los distintos autores, subrayando las diferencias entre ellos y, sobre todo, abogando por un consenso en el campo de los fundamentos de la felicidad. De hecho, la gran diferencia entre los distintos autores es la falta de unanimidad respecto a los fundamentos de la felicidad. Mientras algunos autores optan por un concepto de felicidad que se identifica con el de placer, otros prefieren una mezcla de placer, compromiso y significado, evitando, sin embargo, definir la felicidad o, más bien, ocultándola detrás de la palabra bienestar. Sin embargo, si se lograra un consenso sobre las distintas aportaciones al tema de la felicidad, éste representaría un concepto mucho más manejable desde la perspectiva psicológica.

  11. Pulmonary Fibrosis Foundation

    Science.gov (United States)

    ... submissions. MORE We Imagine a World Without Pulmonary Fibrosis The Pulmonary Fibrosis Foundation mobilizes people and resources to provide ... its battle against the deadly lung disease, pulmonary fibrosis (PF). PULMONARY FIBROSIS WALK SURPASSES PARTICIPATION AND FUNDRAISING GOALS Nearly ...

  12. Contrato de trabajo y empresas de trabajo temporal

    OpenAIRE

    Chacartegui Jávega, Consuelo

    1998-01-01

    Las empresas de trabajo temporal se legalizan en España en el año 1994. A partir de ese momento constituyen un recurso frecuentemente utilizado para llevar a cabo la externalización del trabajo, como proceso que caracteriza en la actualidad a las nuevas formas complejas de organización empresarial. En la tesis se analizan los efectos que ello tiene para los derechos de los trabajadores y cómo se afrontan las responsabilidades empresariales cuando entra en juego una empresa de trabajo temporal...

  13. Pulmonary fibrosis

    International Nuclear Information System (INIS)

    Yamakido, Michio; Okuzaki, Takeshi

    1992-01-01

    When the chest is exposed to x radiation and Co-60 gamma radiation, radiation damage may occur in the lungs 2 to 10 weeks after irradiation. This condition is generally referred to as radiation pneumonitis, with the incidence ranging from 5.4% to 91.8% in the literature. Then radiation pneumonitis may develop into pulmonary fibrosis associated with roentgenologically diffuse linear and ring-like shadows and strong contraction 6 months to one year after irradiation. Until recently, little attention has been paid to pulmonary pneumonitis as a delayed effect of A-bomb radiation. The recent study using the population of 9,253 A-bomb survivors have suggested that the prevalence of pulmonary fibrosis tended to be high in heavily exposed A-bomb survivors. Two other studies using the cohort of 16,956 and 42,728 A-bomb survivors, respectively, have shown that the prevalence of roentgenologically proven pulmonary fibrosis was higher in men than women (1.82% vs 0.41%), was increased with aging and had a higher tendency in heavily exposed A-bomb survivors. (N.K.)

  14. Espacios virtuales para trabajo colaborativo

    OpenAIRE

    Rodríguez, Dario; García Martínez, Ramón; Merlino, Hernán; Charczuk, Norberto; Lacabanne, Marcela; Caracciolo, Bruno; Iglesias, Fernando

    2013-01-01

    Los espacios virtuales de trabajo colaborativo permiten la integración de grupos de trabajo en la que sus miembros no están físicamente contiguos. Hay una amplia literatura vinculada al modelado de las arquitecturas software que soportan este tipo de ambientes. Sin embargo, los formalismos existentes atienden la interacción entre actores y sistema y entre componentes del sistema; descuidando los aspectos de interacción humana.

  15. Familial Pulmonary Fibrosis

    Science.gov (United States)

    ... Education & Training Home Conditions Familial Pulmonary Fibrosis Familial Pulmonary Fibrosis Make an Appointment Find a Doctor Ask a ... more members within the same family have Idiopathic Pulmonary Fibrosis (IPF) or any other form of Idiopathic Interstitial ...

  16. Striking regression of subcutaneous fibrosis induced by high doses of gamma rays using a combination of pentoxifylline and α-tocopherol: an experimental study

    International Nuclear Information System (INIS)

    Lefaix, Jean-Louis; Delanian, Sylvie; Vozenin, Marie-Catherine; Leplat, Jean-Jacques; Tricaud, Yves; Martin, Michele

    1999-01-01

    Purpose: To establish a successful treatment of subcutaneous fibrosis developing after high doses of gamma rays, suitable for use in clinical practice. Methods and Materials: We used an animal model of acute localized gamma irradiation simulating accidental overexposure in humans. Three groups of 5 Large White pigs were irradiated using a collimated 192 Ir source to deliver a single dose of 160 Gy onto the skin surface (100%) of the outer side of the thigh. A well-defined block of necrosis developed within a few weeks which had healed after 26 weeks to leave a block of subcutaneous fibrosis involving skin and skeletal muscle. One experimental group of 5 pigs was dosed orally for 26 weeks starting 26 weeks after irradiation with 1600 mg/120 kg body weight of pentoxifylline (PTX) included in the reconstituted food during its fabrication, and another group of 5 was dosed orally for the same period with a daily dose of 1600 mg/120 kg body weight of PTX combined with 2000 IU/120 kg body weight of α-tocopherol. Five irradiated control pigs were given normal food only. Animals were assessed for changes in the density of the palpated fibrotic block and in the dimensions of the projected cutaneous surface. Depth of scar tissue was determined by ultrasound. Physical and sonographic findings were confirmed by autopsy 26 weeks after treatment started. The density, length, width, and depth of the block of fibrotic scar tissue, and the areas and volume of its projected cutaneous surface, were compared before treatment, 6 and 13 weeks thereafter, and at 26 weeks. Results: The experimental animals exhibited no change in behavior and no abnormal clinical or anatomic signs. No modifications were observed in the block of fibrotic scar tissue of pigs dosed with PTX alone. However, significant softening and shrinking of this block were noted in the pigs dosed with PTX + α-tocopherol 13 weeks after treatment started and at autopsy, when mean regression was ∼ 30% for length, ∼ 50

  17. Condiciones laborales del trabajo nocturno

    OpenAIRE

    Corrales Moreno, María Antonia

    2016-01-01

    RESUMEN: Considerado excepcional hace un tiempo, el trabajo nocturno (y el sistema a turnos) se ha convertido en una forma cada vez más habitual de prestar servicios. En este sentido, razones tecnológicas, económicas y sociales justifican que se imponga en más actividades y afecte a un mayor número de trabajadores (sanidad, transporte, comercio, hostelería, limpieza, vigilancia y, por excelencia, a la industria). No obstante, el trabajo nocturno afecta necesariamente a la salud del trabajador...

  18. Localization of ανβ6 integrin-TGF-β1/Smad3, mTOR and PPARγ in experimental colorectal fibrosis

    Directory of Open Access Journals (Sweden)

    G. Latella

    2013-12-01

    Full Text Available A simultaneous action of several pro-fibrotic mediators appears relevant in the development of fibrosis. There are evidences that transforming growth factor-β (TGF-β/Smad3 pathway forms with αvβ6 integrin, mammalian target of Rapamycin (mTOR and peroxisome proliferator-activated receptor-γ (PPARγ a complex signalling network with extensive crosstalk and strong effects on fibrosis development. The present study evaluated the expression of TGFβ, Smad3, αvβ6 integrin, mTOR and PPARγ in 2, 4, 6-trinitrobenzenesulphonic acid (TNBS-induced colorectal fibrosis in Smad3 wild-type (WT and null mice. Smad3 WT mice treated with TNBS developed a marked colorectal fibrosis and showed a concomitant up-regulation of TGFβ, Smad3, αvβ6 and mTOR and a reduction of PPARγ expression. On the other hand, Smad3 Null mice similarly treated with TNBS did not develop fibrosis and showed a very low or even absent expression of TGFβ, Smad3, αvβ6 and mTOR and a marked over-expression of PPARγ. At the same time the expression of α-smooth muscle actin (a marker of activated myofibroblasts, collagen I-III and connective tissue growth factor (a downstream effector of TGFβ/Smad3-induced extracellular matrix proteins were up-regulated in Smad3 WT mice treated with TNBS compared to Null TNBS-treated mice. These preliminary results suggest a possible interaction between these pro-fibrotic molecules in the development of intestinal fibrosis.

  19. Idiomas, diversidad y trabajo social

    DEFF Research Database (Denmark)

    Jensen, Niels Rosendal

    2010-01-01

    Anmeldelsen af tidsskriftet Revista de Trabajo Social tager udgangspunkt i, at socialpædagoger og socialarbejdere tilsyneladende kun er optaget af begrebet sprog i et beskedent omfang, selv om sproget fylder så ufatteligt meget i deres hverdagsliv (faglig kommunikation osv.). Udgivelsesdato: Marts...

  20. Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2

    Directory of Open Access Journals (Sweden)

    Ritu S. Sharma

    2018-01-01

    Conclusions: Pharmacologic activation of Nrf2 in mice that had already been rendered obese and insulin resistant reversed insulin resistance, suppressed hepatic steatosis, and mitigated against NASH and liver fibrosis, effects that we principally attribute to inhibition of ER, inflammatory, and oxidative stress.

  1. The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury.

    Science.gov (United States)

    Rathinasabapathy, Anandharajan; Horowitz, Alana; Horton, Kelsey; Kumar, Ashok; Gladson, Santhi; Unger, Thomas; Martinez, Diana; Bedse, Gaurav; West, James; Raizada, Mohan K; Steckelings, Ulrike M; Sumners, Colin; Katovich, Michael J; Shenoy, Vinayak

    2018-01-01

    Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung disease characterized by scar formation and respiratory insufficiency, which progressively leads to death. Pulmonary hypertension (PH) is a common complication of IPF that negatively impacts clinical outcomes, and has been classified as Group III PH. Despite scientific advances, the dismal prognosis of IPF and associated PH remains unchanged, necessitating the search for novel therapeutic strategies. Accumulating evidence suggests that stimulation of the angiotensin II type 2 (AT 2 ) receptor confers protection against a host of diseases. In this study, we investigated the therapeutic potential of Compound 21 (C21), a selective AT 2 receptor agonist in the bleomycin model of lung injury. A single intra-tracheal administration of bleomycin (2.5 mg/kg) to 8-week old male Sprague Dawley rats resulted in lung fibrosis and PH. Two experimental protocols were followed: C21 was administered (0.03 mg/kg/day, ip) either immediately (prevention protocol, BCP) or after 3 days (treatment protocol, BCT) of bleomycin-instillation. Echocardiography, hemodynamic, and Fulton's index assessments were performed after 2 weeks of bleomycin-instillation. Lung tissue was processed for gene expression, hydroxyproline content (a marker of collagen deposition), and histological analysis. C21 treatment prevented as well as attenuated the progression of lung fibrosis, and accompanying PH. The beneficial effects of C21 were associated with decreased infiltration of macrophages in the lungs, reduced lung inflammation and diminished pulmonary collagen accumulation. Further, C21 treatment also improved pulmonary pressure, reduced muscularization of the pulmonary vessels and normalized cardiac function in both the experimental protocols. However, there were no major differences in any of the outcomes measured from the two experimental protocols. Collectively, our findings indicate that stimulation of the AT 2 receptor by C21 attenuates

  2. The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury

    Directory of Open Access Journals (Sweden)

    Anandharajan Rathinasabapathy

    2018-03-01

    Full Text Available Idiopathic Pulmonary Fibrosis (IPF is a chronic lung disease characterized by scar formation and respiratory insufficiency, which progressively leads to death. Pulmonary hypertension (PH is a common complication of IPF that negatively impacts clinical outcomes, and has been classified as Group III PH. Despite scientific advances, the dismal prognosis of IPF and associated PH remains unchanged, necessitating the search for novel therapeutic strategies. Accumulating evidence suggests that stimulation of the angiotensin II type 2 (AT2 receptor confers protection against a host of diseases. In this study, we investigated the therapeutic potential of Compound 21 (C21, a selective AT2 receptor agonist in the bleomycin model of lung injury. A single intra-tracheal administration of bleomycin (2.5 mg/kg to 8-week old male Sprague Dawley rats resulted in lung fibrosis and PH. Two experimental protocols were followed: C21 was administered (0.03 mg/kg/day, ip either immediately (prevention protocol, BCP or after 3 days (treatment protocol, BCT of bleomycin-instillation. Echocardiography, hemodynamic, and Fulton's index assessments were performed after 2 weeks of bleomycin-instillation. Lung tissue was processed for gene expression, hydroxyproline content (a marker of collagen deposition, and histological analysis. C21 treatment prevented as well as attenuated the progression of lung fibrosis, and accompanying PH. The beneficial effects of C21 were associated with decreased infiltration of macrophages in the lungs, reduced lung inflammation and diminished pulmonary collagen accumulation. Further, C21 treatment also improved pulmonary pressure, reduced muscularization of the pulmonary vessels and normalized cardiac function in both the experimental protocols. However, there were no major differences in any of the outcomes measured from the two experimental protocols. Collectively, our findings indicate that stimulation of the AT2 receptor by C21 attenuates

  3. Trabajo infantil e inasistencia escolar

    Directory of Open Access Journals (Sweden)

    Antonio Sandoval Ávila

    2007-01-01

    Full Text Available Trabajo infantil e inasistencia escolar El capitalismo neoliberal ha generalizado la pobreza que obliga a muchas familias a recurrir al trabajo de los hijos para poder subsistir. Por el trabajo, los menores desertan de la escuela. Cuando adultos, por la pérdida en educación, sólo podrán acceder a las ocupaciones de menor calificación y peor pagadas. Por ello, tienen muchas probabilidades de ser los futuros padres de nuevos niños trabajadores reproduciendo intergeneracionalmente la pobreza. La educación es el primer paso para romper el círculo de la pobreza; hay relación entre los niveles de educación y las remuneraciones que las ersonas pueden alcanzar. El desarrollo descansa en el acelerado cambio tecnológico que no es más que el conocimiento científico aplicado a la producción. Crear conocimiento supone educación superior, y en la base de ésta está la educación básica, que es el cimiento de cualquier modelo de desarrollo que aspire a la equidad. No educar a los menores significa desperdiciar la formación de capital humano, ello traba el desarrollo nacional. Sin educación no habrá capital humano calificado como motor básico de la productividad y la competitividad.

  4. El Derecho universal del Trabajo

    Directory of Open Access Journals (Sweden)

    Héctor-Hugo Barbagelata

    2014-01-01

    Full Text Available La idea de un derecho universal del trabajo no es nueva, en realidad es más antigua quela legislación del trabajo y por lo tanto, más antigua que la propia rama del derecho que estudia estas cuestiones.Sí, son nuevos los avances que con ese objetivo se han ido registrando desde fines del siglo pasado.I- Introducción.- II Antecedentes.- II Constitucionalización e internacionalización.- IV Principios y criterios de interpretación del bloque de constitucionalidad.- A Criterio fundado en las condiciones del Estado Social de Derecho; B Principio de complementariedad e interdependencia de todas las normas sobre derechos humanos; C Primacía de la disposición más favorable a la persona humana; D Criterio resultante del principio de progresividad.; E Principio de irreversibilidad o de no regresión. F Principio de autoejecución y autoaplicación..- V Conflictos entre los derechos fundamentales .- VI.- Los principios filosóficos: a La Justicia social ; b La especificidad del trabajo humano; c Reafirmación de la dignidad de la persona humana; VII Conclusiones. 

  5. Cystic fibrosis: case report

    International Nuclear Information System (INIS)

    Park, Si Hyun; Lee, Hyun Ju; Kim, Ji Hye; Park, Chol Heui

    2002-01-01

    Cystic fibrosis is an autosomal recessive genetic disease. Among Caucasians, it is the most common cause of pulmonary insufficiency during the first three decades of life. The prevalence of cystic fibrosis varies according to ethnic origin: it is common among Caucasians but rare among Asians. We report a case in which cystic fibrosis with bronchiectasis and hyperaeration was revealed by high-resolution CT, and mutation of the cystic fibrosis conductance transmembrane regulator gene (CFTR) by DNA analysis

  6. Cystic fibrosis: case report

    International Nuclear Information System (INIS)

    Park, Si Hyun; Lee, Hyun Ju; Kim, Ji Hye; Park, Chol Heui

    2002-01-01

    Cystic fibrosis is a autosomal recessive genetic disease. Among caucasians, it is the most common cause of pulmonary insufficiency during the first three decades of life. The prevalence of cystic fibrosis varies according to ethnic origin: it is common among caucasians but rare among Asians. We report a case in which cystic fibrosis with bronchiectasis and hyperaeration was revealed by high-resolution CT, and mutation of the cystic fibrosis conductance transmembrane regulator gene (CFTR) by DNA analysis

  7. Cystic Fibrosis (CF): Chloride Sweat Test

    Science.gov (United States)

    ... on this topic for: Parents Kids Teens Cystic Fibrosis Cystic Fibrosis and Nutrition Cystic Fibrosis (CF) Respiratory Screen: Sputum Cystic Fibrosis: Diet and Nutrition Cystic Fibrosis Cystic Fibrosis: Diet and Nutrition View more Partner Message ...

  8. Modeling the mechanical properties of liver fibrosis in rats.

    Science.gov (United States)

    Zhu, Ying; Chen, Xin; Zhang, Xinyu; Chen, Siping; Shen, Yuanyuan; Song, Liang

    2016-06-14

    The progression of liver fibrosis changes the biomechanical properties of liver tissue. This study characterized and compared different liver fibrosis stages in rats in terms of viscoelasticity. Three viscoelastic models, the Voigt, Maxwell, and Zener models, were applied to experimental data from rheometer tests and then the elasticity and viscosity were estimated for each fibrosis stage. The study found that both elasticity and viscosity are correlated with the various stages of liver fibrosis. The study revealed that the Zener model is the optimal model for describing the mechanical properties of each fibrosis stage, but there is no significant difference between the Zener and Voigt models in their performance on liver fibrosis staging. Therefore the Voigt model can still be effectively used for liver fibrosis grading. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.

    Directory of Open Access Journals (Sweden)

    Belén Picatoste

    Full Text Available BACKGROUND: Myocardial fibrosis is a key process in diabetic cardiomyopathy. However, their underlying mechanisms have not been elucidated, leading to a lack of therapy. The glucagon-like peptide-1 (GLP-1 enhancer, sitagliptin, reduces hyperglycemia but may also trigger direct effects on the heart. METHODS: Goto-Kakizaki (GK rats developed type-II diabetes and received sitagliptin, an anti-hyperglycemic drug (metformin or vehicle (n=10, each. After cardiac structure and function assessment, plasma and left ventricles were isolated for biochemical studies. Cultured cardiomyocytes and fibroblasts were used for in vitro assays. RESULTS: Untreated GK rats exhibited hyperglycemia, hyperlipidemia, plasma GLP-1 decrease, and cardiac cell-death, hypertrophy, fibrosis and prolonged deceleration time. Moreover, cardiac pro-apoptotic/necrotic, hypertrophic and fibrotic factors were up-regulated. Importantly, both sitagliptin and metformin lessened all these parameters. In cultured cardiomyocytes and cardiac fibroblasts, high-concentration of palmitate or glucose induced cell-death, hypertrophy and fibrosis. Interestingly, GLP-1 and its insulinotropic-inactive metabolite, GLP-1(9-36, alleviated these responses. In addition, despite a specific GLP-1 receptor was only detected in cardiomyocytes, GLP-1 isoforms attenuated the pro-fibrotic expression in cardiomyocytes and fibroblasts. In addition, GLP-1 receptor signalling may be linked to PPARδ activation, and metformin may also exhibit anti-apoptotic/necrotic and anti-fibrotic direct effects in cardiac cells. CONCLUSIONS: Sitagliptin, via GLP-1 stabilization, promoted cardioprotection in type-II diabetic hearts primarily by limiting hyperglycemia e hyperlipidemia. However, GLP-1 and GLP-1(9-36 promoted survival and anti-hypertrophic/fibrotic effects on cultured cardiac cells, suggesting cell-autonomous cardioprotective actions.

  10. Hepatic fibrosis: Concept to treatment.

    Science.gov (United States)

    Trautwein, Christian; Friedman, Scott L; Schuppan, Detlef; Pinzani, Massimo

    2015-04-01

    Understanding the molecular mechanisms underlying liver fibrogenesis is fundamentally relevant to developing new treatments that are independent of the underlying etiology. The increasing success of antiviral treatments in blocking or reversing the fibrogenic progression of chronic liver disease has unearthed vital information about the natural history of fibrosis regression, and has established important principles and targets for antifibrotic drugs. Although antifibrotic activity has been demonstrated for many compounds in vitro and in animal models, none has been thoroughly validated in the clinic or commercialized as a therapy for fibrosis. In addition, it is likely that combination therapies that affect two or more key pathogenic targets and/or pathways will be needed. To accelerate the preclinical development of these combination therapies, reliable single target validation is necessary, followed by the rational selection and systematic testing of combination approaches. Improved noninvasive tools for the assessment of fibrosis content, fibrogenesis and fibrolysis must accompany in vivo validation in experimental fibrosis models, and especially in clinical trials. The rapidly changing landscape of clinical trial design for liver disease is recognized by regulatory agencies in the United States (FDA) and Western Europe (EMA), who are working together with the broad range of stakeholders to standardize approaches to testing antifibrotic drugs in cohorts of patients with chronic liver diseases. Copyright © 2015. Published by Elsevier B.V.

  11. Informes y documentos de Trabajo

    DEFF Research Database (Denmark)

    Humlebæk, Carsten

    El propósito de este artículo es reflexionar y proponer hipótesis explicativas a las dificultades de la izquierda para articular un discurso nacionalista español. El trabajo se enmarca dentro del proyecto “Nacionalismo español: discursos y praxis desde la izquierda (1982-2008)” financiado por el ...... forma apriorística. Finalmente, este documento es el armazón teórico sobre el que se pretende ensamblar una de las publicaciones finales del proyecto: el libro que resuma los hallazgos y las aportaciones principales de nuestra investigación al conocimiento de la realidad española....

  12. Diseño experimental de un sumidero de CO2 y sus implicaciones en el cambio climático. Una experiencia de trabajo con alumnos en el laboratorio de Educación Secundaria

    Directory of Open Access Journals (Sweden)

    Raquel Boronat-Gil

    2018-01-01

    Full Text Available El desarrollo teórico del cambio climático en el aula de Educación Secundaria requiere de experiencias recreativas que demuestren –in situ– diferentes aspectos del proceso global. La presente comunicación muestra una actividad de laboratorio, y el consiguiente trabajo del alumnado, para comprobar la reducción de gases de efecto invernadero mediante la aplicación de una tecnología básica, de bajo costo y que puede realizarse con materiales disponibles en cualquier laboratorio escolar. La analogía didáctica llevada a cabo entre el CO2 producido por el metabolismo microbiano dentro de una botella cerrada y su reacción con una base fuerte generadora de una presión inferior a la atmosférica (como consecuencia de la reacción del dióxido de carbono con una base, visible con un sencillo manómetro en U, será objeto de debate entre profesor-alumno, analizándose y especulando su captura con la repercusión a nivel mundial de mejora en el calentamiento global.

  13. Modulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosis

    Directory of Open Access Journals (Sweden)

    Nilgün Tekkesin

    2013-06-01

    Full Text Available Hepatic fibrosis is now regarded as a common response to chronic liver injury; regardless of its nature (viral infections, alcohol abuse and metal overload. It is also characterized by excessive deposition of extracellular matrix (ECM components. The ECM is a dynamic complex of macromolecules that includes collagens, glycoproteins, and proteoglycans, such as laminin and fibronectin; it has been shown that it does not only support the tissue structure, but also plays a major role in cell adhesion, proliferation, and differentiation. Remodelling of the ECM may be the signal that facilitates lobular reorganization during liver regeneration after a liver injury. Much work has been done concerning the ECM synthesis and protein contents.

  14. Neonatal cystic fibrosis screening test

    Science.gov (United States)

    Cystic fibrosis screening - neonatal; Immunoreactive trypsinogen; IRT test; CF - screening ... Cystic fibrosis is a disease passed down through families. CF causes thick, sticky mucus to build up in ...

  15. Imaging pulmonary fibrosis

    International Nuclear Information System (INIS)

    Brauner, M.W.; Rety, F.; Naccache, J.M.; Girard, F.; Valeyre, D.F.

    2001-01-01

    Localized fibrosis of the lung is usually scar tissue while diffuse pulmonary fibrosis is more often a sign of active disease. Chronic infiltrative lung disease may be classified into four categories: idiopathic pneumonitis, collagen diseases, granulomatosis (sarcoidosis), and caused by known diseases (pneumoconiosis, hypersensitivity pneumonitis, drug-induced lung disease, radiation). (authors)

  16. Angiogenesis in liver fibrosis

    NARCIS (Netherlands)

    Adlia, Amirah

    2017-01-01

    Angiogenesis emerges in parallel with liver fibrosis, but it is still unclear whether angiogenesis is a defense mechanism of the body in response to fibrosis, or whether it aggravates the fibrotic condition. In this thesis, Amirah Adlia applied different approaches to elucidate the role of

  17. Fibrosis and Cancer

    DEFF Research Database (Denmark)

    Cox, Thomas R.; Erler, Janine T.

    2016-01-01

    The relation between fibrosis and cancer has long been debated, specifically whether desmoplasia precedes, accompanies, or succeeds tumourigenesis, progression, and metastasis. Recent reports have published opposing data, adding to the perplexity. However, what is emerging is that it is likely th...... the specific properties of the extracellular matrix (ECM) that determine the paradoxical nature of cancer-associated fibrosis....

  18. Diagnosis of cystic fibrosis

    NARCIS (Netherlands)

    H.J. Veeze

    1995-01-01

    textabstractApplying the sweat-test as the first choice of test when a diagnosis of cystic fibrosis is suspected is still common practice and advisable. Since the cloning of the CFTR gene more than 400 different cystic fibrosis (CF) mutations have already been identified. The use of CF mutation

  19. Morphological aspects of the myocarditis and myositis in Calomys callosus experimentally infected with Trypanosoma cruzi: fibrogenesis and spontaneous regression of fibrosis

    Directory of Open Access Journals (Sweden)

    Sonia G. Andrade

    1994-09-01

    Full Text Available Calomys callosus a wild rodent, is a natural host of Trypanosoma cruzi. Twelve C. callosus were infected with 10(5 trypomastigotes of the F strain (a myotropic strain of T. cruzi. Parasitemia decreased on the 21 st day becoming negative around the 40th day of infection. All animals survived but had positive parasitological tests, until the end of the experiment. The infected animals developed severe inflammation in the myocardium and skeletal muscle. This process was pronounced from the 26 th to the 30th day and gradually subsided from the 50 th day becoming absent or residual on the 64 th day after infection. Collagen was identified by the picro Sirius red method. Fibrogenesis developed early, but regression of fibrosis occurred between the 50th and 64th day. Ultrastructural study disclosed a predominance of macrophages and fibroblasts in the inflammatory infiltrates, with small numbers of lymphocytes. Macrophages had active phagocytosis and showed points of contact with altered muscle cells. Different degrees of matrix expansion were present, with granular and fibrilar deposits and collagen bundles. These alterations subsided by the 64th days. Macrophages seem to be the main immune effector cell in the C. callosus model of infection with T. cruzi. The mechanisms involved in the rapid fibrogenesis and its regression deserve further investigation.

  20. Parasitologia. Trabajos aislados. (Trematodes-artropodos (contiuación

    Directory of Open Access Journals (Sweden)

    Alfonso Bonilla Naar

    1945-04-01

    Full Text Available (29 trabajos. 1888-1944. P Parasitosis intestinales (60 trabajos, 1876-1942. P Patología regional (44 trabajos. 1880-1943. Pelagra. (5 trabajos. 1884-1925. Peste bubónica (12 trabajos. 1899-1915. Pian o bubas (16 trabajos. 1910-1943.

  1. PERFILES PROFESIONALES Y VALORES RELATIVOS AL TRABAJO

    OpenAIRE

    Moreno, José Eduardo; Marcaccio, Antonela

    2014-01-01

    El objetivo del presente trabajo es evaluar la relación existente entre los valores relativos al trabajo y algunos perfiles profesionales (contabilidad y administración, marketing y ventas, y recepción). El instrumento utilizado es la Escala Argentina de Valores Relativos al Trabajo (Moreno & Marcaccio, 2012) que contiene cuatro subescalas de cinco ítems cada una, a saber: Realización Personal, Reconocimiento Social, Altruismo y Aspiraciones Económicas. La muestra incluye a 425 sujetos (40% v...

  2. LAS METAMORFOSIS EN EL MUNDO DEL TRABAJO

    Directory of Open Access Journals (Sweden)

    Ricardo Antunes

    2000-01-01

    Full Text Available En este capítulo el autor aborda las distintas dimensiones que adquiere hoy el mundo del trabajo inscrito en el capitalismo contemporáneo: desproletarización del trabajo industrial mientras se presenta una notoria expansión de asalariados en el sector servicios; creciente heterogenización del ámbito laboral manifiesto fundamentalmente en la incorporación amplia de mujeres; subproletarización intensificada a través de la expansión del trabajo parcial, temporal, precario, subcontratado, "tercerizado".

  3. Las metamorfosis en el mundo del trabajo

    Directory of Open Access Journals (Sweden)

    Ricardo Antunes

    2000-04-01

    Full Text Available En este capítulo el autor aborda las distintas dimensiones que adquiere hoy el mundo del trabajo inscrito en el capitalismo contemporáneo: desproletarización del trabajo industrial mientras se presenta una notoria expansión de asalariados en el sector servicios; creciente heterogenización del ámbito laboral manifiesto fundamentalmente en la incorporación amplia de mujeres; subproletarización intensificada a través de la expansión del trabajo parcial, temporal, precario, subcontratado, “tercerizado”.

  4. Trabajando en crear felicidad en el trabajo

    OpenAIRE

    Rodríguez González, Elena

    2016-01-01

    Treball final de Màster Universitari en Psicologia del Treball, de les Organitzacions i en Recursos Humans. Codi: SBE513. Curs acadèmic 2015-2016 Como su propio nombre indica, el siguiente trabajo es el final del camino recorrido en el Máster en Psicología del Trabajo, de las Organizaciones y en Recursos Humanos. En él resumo los conocimientos adquiridos a lo largo del mismo, así como las competencias conseguidas y el camino realizado para su obtención. Cada aspecto del máster ha ...

  5. Radio universitaria: trabajo en red como imperativo

    Directory of Open Access Journals (Sweden)

    Tiziana Cavallo

    2014-01-01

    Full Text Available Trabajo en red es un concepto clave en la radio universitaria, tanto desde el punto de vista individual como del colectivo. A través de dos estudios de caso, enfocados en la radio universitaria de Italia y de Colombia, este artículo muestra cómo el trabajo en red ha sido decisivo para el fortalecimiento de su función, la ampliación de su impacto, la conformación de su identidad y el crecimiento de su visibilidad en las sociedades en las cuales desarrollan su labor.

  6. Acerca del trabajo en grupos o equipos

    OpenAIRE

    Gómez Mujica, Aleida; Acosta Rodríguez, Heriberto

    2003-01-01

    Se definen, caracterizan y comparan los grupos y equipos de trabajo. Se señalan las características y funciones que convierten gradual y paulatinamente un grupo en un equipo de trabajo. Se señalan las ventajas y desventajas de cada uno de ellos, tanto para los individuos como para las organizaciones. Se analizan algunas variables estructurales, las normas para la formación de los equipos, las características esenciales y las funciones que desempeñan sus miembros. Se anexa una lista con las ca...

  7. Trabajos informales femeninos: la costura, Santander 1829

    OpenAIRE

    Leal Díez, Sandra

    2014-01-01

    RESUMEN: La incorporación de la mujer al mercado de trabajo ha sido –y sigue siendo en algunos casos- un proceso costoso de llevar a cabo. El presente Trabajo de Fin de Grado está basado en el estudio de los oficios informales durante la primera mitad del siglo XIX, época especialmente conflictiva debido al momento económico y político que se daba en España. Intentar abarcar toda esta temática sería casi imposible, por lo tanto, se ha optado por realizar un estudio más concreto...

  8. Biomarcadores para fibrosis hepática, avances, ventajas y desventajas

    Directory of Open Access Journals (Sweden)

    A. Cequera

    2014-07-01

    En este trabajo se describen los biomarcadores empleados actualmente para el estudio de la fibrosis hepática en humanos, incluyendo sus ventajas y desventajas y la implementación de tecnologías de nueva generación, y la evaluación de las posibilidades de su empleo para el diagnóstico.

  9. Nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Marckmann, Peter; Skov, Lone; Rossen, Kristian

    2006-01-01

    Nephrogenic systemic fibrosis is a new, rare disease of unknown cause that affects patients with renal failure. Single cases led to the suspicion of a causative role of gadodiamide that is used for magnetic resonance imaging. This study therefore reviewed all of the authors' confirmed cases...... of nephrogenic systemic fibrosis (n = 13) with respect to clinical characteristics, gadodiamide exposure, and subsequent clinical course. It was found that all had been exposed to gadodiamide before the development of nephrogenic systemic fibrosis. The delay from exposure to first sign of the disease was 2 to 75...... d (median 25 d). Odds ratio for acquiring the disease when gadodiamide exposed was 32.5 (95% confidence interval 1.9 to 549.2; P

  10. Syndecans in heart fibrosis.

    Science.gov (United States)

    Lunde, Ida G; Herum, Kate M; Carlson, Cathrine C; Christensen, Geir

    2016-09-01

    Heart disease is a deadly syndrome affecting millions worldwide. It reflects an unmet clinical need, and the disease mechanisms are poorly understood. Cardiac fibrosis is central to heart disease. The four-membered family of transmembrane proteoglycans, syndecan-1 to -4, is believed to regulate fibrosis. We review the current literature concerning syndecans in cardiac fibrosis. Syndecan expression is up-regulated in response to pro-inflammatory stimuli in various forms of heart disease with fibrosis. Mice lacking syndecan-1 and -4 show reduced activation of pro-fibrotic signaling and increased cardiac rupture upon infarction indicating an important role for these molecules. Whereas the short cytoplasmic tail of syndecans regulates signaling, their extracellular part, substituted with heparan sulfate glycosaminoglycan chains, binds a plethora of extracellular matrix (ECM) molecules involved in fibrosis, e.g., collagens, growth factors, cytokines, and immune cell adhesion proteins. Full-length syndecans induce pro-fibrotic signaling, increasing the expression of collagens, myofibroblast differentiation factors, ECM enzymes, growth factors, and immune cell adhesion molecules, thereby also increasing cardiac stiffness and preventing cardiac rupture. Upon pro-inflammatory stimuli, syndecan ectodomains are enzymatically released from heart cells (syndecan shedding). Shed ectodomains affect the expression of ECM molecules, promoting ECM degradation and cardiac rupture upon myocardial infarction. Blood levels of shed syndecan-1 and -4 ectodomains are associated with hospitalization, mortality, and heart remodeling in patients with heart failure. Improved understanding of syndecans and their modifying enzymes in cardiac fibrosis might contribute to the development of compounds with therapeutic potential, and enzymatically shed syndecan ectodomains might constitute a future prognostic tool for heart diseases with fibrosis. Graphical Abstract Graphical abstract summarizing

  11. Endomyocardial fibrosis in infancy

    Directory of Open Access Journals (Sweden)

    Jatene Marcelo Biscegli

    2003-01-01

    Full Text Available The patient was a 4-month-old infant, who underwent persistent ductus arteriosus interruption with titanium clips at the age of 13 days and, since the age of 2 months, had crises of hypoxia and hypertonicity. After clinical investigation, the presence of pulmonary hypertension was confirmed and left ventricular inflow tract obstruction was suspected. The patient underwent surgical treatment at the age of 4 months, during which right and left ventricular endocardial fibrosis was identified. The fibrosis was resected, but the infant had an unfavorable clinical evolution with significant diastolic restriction and died on the sixth postoperative day. Anatomicopathological and surgical findings suggested endomyocardial fibrosis, although that pathology is very rare at the patient's age.

  12. Homofobia en estudiantes de trabajo social

    Directory of Open Access Journals (Sweden)

    Adalberto Campo-Arias

    2013-01-01

    Full Text Available La homofobia es una actitud negativa ante personas homosexuales. Varios estudios infor - man altos niveles de homofobia en estudiantes universitarios. Estimar el nivel de homofo - bia en estudiantes de trabajo social. Se llevó a cabo una revisión sistemática de las inves - tigaciones formales disponibles en Ebsco, Imbiomed, Lilacs, MedLine, Ovid y ProQuest. Se incluyeron artículos publicados en español, inglés o portugués entre 1999 y 2010. Las palabras clave para la búsqueda fueron “homophobia”, “homosexuality”, “students” y “social work”. Se realizó un análisis descriptivo de los hallazgos. Un grupo de tres artícu - los se incluyeron en esta revisión. Entre el 6,5 y 77,4% de los estudiantes de trabajo social mostraron altos niveles de homofobia. Al menos uno de cada quince estudiantes de trabajo social informan altos niveles homofobia. En estudiantes colombianos de trabajo social es necesario investigar la presencia de homofobia.

  13. Productividad, trabajo y salud: la perspectiva psicosocial

    Directory of Open Access Journals (Sweden)

    York Iván Puerto Barrios

    2007-07-01

    Full Text Available Con la opción de analizar las condiciones de trabajo en oficina, el texto realiza una sucinta pero precisa revisión de la conceptualización sobre productividad y consumo. Se documenta la relación contradictoria entre bienestar y rendimiento en el trabajo al identificar el riesgo de llevar al límite de sus capacidades la participación del trabajador como factor de productividad, ignorando que éste tiene además el rol de consumidor activo de bienes y servicios para que la producción tenga sentido. Se plantea que exigir al trabajador hasta su agotamiento puede mermar sustancialmente su doble condición de productor y consumidor. Específicamente, se presenta la perspectiva del trabajo en oficinas innovadas conceptual y tecnológicamente, con procesos laborales y patrones de desgaste y morbilidad de"nidos. El tiempo, el ritmo, la parcelación, el control del trabajo y la reestructuración en las organizaciones son, entre otros, factores que convergen para potenciar fenómenos de sobrecarga o subcarga mental con la consecuente aparición de estrés excedente y sus patologías asociadas.

  14. Crisis y Derecho del Trabajo: viejos conocidos

    Directory of Open Access Journals (Sweden)

    Oscar Ermida Uriarte

    2014-04-01

    Full Text Available Buenas noches: Mi papel aquí es el de hacer una presentación general del tema que sirva de introducción a lo que luego profundizarán los Profesores Rosenbaun y Loustaunau, tanto en lo que tiene que ver con la negociación colectiva, como en lo relacionado con las experiencias concretas que se han dado en nuestro país.Para hacer ese planteamiento panorámico inicial, vamos a tratar cinco puntos: Primeramente, abordaremos la crisis y el Derecho del trabajo como una relación que de algún modo es vieja y conocida, aunque cada vez se plantea con alguna novedad. En segundo lugar haremos referencia a algunas particularidades de la crisis actual. En tercer lugar, señalaremos los efectos específicos de las crisis económicas sobre el Derecho del trabajo. En cuarto término, intentaremos introducir una sistematización de los instrumentos laborales de enfrentamiento a la crisis, respondiendo a la pregunta ¿qué instrumentos tiene el Derecho del trabajo para enfrentar la crisis? Y en quintolugar, nos referiremos a las medidas extra laborales de enfrentamiento de la crisis, es decir, aquello que se puede hacer para enfrentar las crisis, no solo desde el Derecho del trabajo, sino desde fuera del Derecho del Trabajo.

  15. Nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Khurram, Misbah; Skov, Lone; Rossen, Kristian

    2007-01-01

    Nephrogenic systemic fibrosis (NSF) is a fibrotic disease seen in renal failure patients that may lead to severe physical disability. It has been demonstrated in recent studies that NSF can be caused by some gadolinium-containing MRI contrast agents. In this report we present one of a total of 26...

  16. Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis

    Directory of Open Access Journals (Sweden)

    Jamille Souza Fernandes

    2014-01-01

    Full Text Available A major issue with Schistosoma mansoni infection is the development of periportal fibrosis, which is predominantly caused by the host immune response to egg antigens. Experimental studies have pointed to the participation of monocytes in the pathogenesis of liver fibrosis. The aim of this study was to characterize the subsets of monocytes in individuals with different degrees of periportal fibrosis secondary to schistosomiasis. Monocytes were classified into classical (CD14++CD16−, intermediate (CD14++CD16+, and nonclassical (CD14+CD16++. The expressions of monocyte markers and cytokines were assessed using flow cytometry. The frequency of classical monocytes was higher than the other subsets. The expression of HLA-DR, IL-6, TNF-α, and TGF-β was higher in monocytes from individuals with moderate to severe fibrosis as compared to other groups. Although no differences were observed in receptors expression (IL-4R and IL-10R between groups of patients, the expression of IL-12 was lower in monocytes from individuals with moderate to severe fibrosis, suggesting a protective role of this cytokine in the development of fibrosis. Our data support the hypothesis that the three different monocyte populations participate in the immunopathogenesis of periportal fibrosis, since they express high levels of proinflammatory and profibrotic cytokines and low levels of regulatory markers.

  17. El modelo de trabajo en equipo

    OpenAIRE

    Iñaki Rodríguez Cueto

    2008-01-01

    El modelo de trabajo en equipo constituye una herramienta basica en cualquier organizacion que quiera conseguir los objetivos propuestos y, ademas, lo quiera conseguir dentro de parametros de eficacia y calidad.En el entorno de la Comunidad Terapeutica cobra mayor importancia el dominio de saber trabajar en equipo debido a la necesidad de conjugar aspectos psico-terapeuticos, educativos, medicos e, incluso, administrativos a la hora de planificar el tratamiento a nivel grupal e individual.El ...

  18. Factores psicosociales del trabajo con computador

    Directory of Open Access Journals (Sweden)

    Guerrero Juan

    1996-12-01

    Full Text Available

    The generalized use of the computer in all the social activity fields imposes the identification of those critical aspects of their implementation. This paper it's a detailed review of the psychosocial factors inherent to the relationship between the health and the computer work at the office. The factors documented are: organizational, ergonomics, those of the requirements of the work and those of the personal characteristics of the computer users.

    El uso generalizado del computador en todos los campos de actividad social impone la identificación de aquellos aspectos críticos de su implementación. En este trabajo se elabora una detallada revisión de los factores psicosociales inherentes a la relación entre la salud y el trabajo con computador en las oficinas. Se documentan los factores organizacionales, los ergonómicos, los de las exigencias del trabajo y los de las características personales de los usuarios de computadores.

  19. Nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Marckmann, Peter

    2008-01-01

    PURPOSE OF REVIEW: The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. RECENT FINDINGS: Epidemiological and histochemical studies demonstrated....... Increasingly poor renal function, aberrations in calcium-phosphate metabolism and erythropoietin treatment seem to increase the risk of the disease and its severity. Up to 25-30% of patients with renal failure exposed to gadolinium-based contrast agents may develop nephrogenic systemic disease. The figure...... that gadolinium-containing contrast agents used for magnetic resonance imaging have an essential causative role in most, if not all, cases of nephrogenic systemic fibrosis. One particular agent, gadodiamide, caused the majority of cases, but gadopentetate dimeglumine has also been implicated in several cases...

  20. Radiation pneumonitis and fibrosis

    International Nuclear Information System (INIS)

    Shopova, V.; Salovsky, P.; Dancheva, V.

    2001-01-01

    The likelihood of toxic pulmonary lesions development as the result of radiation therapy for pulmonary carcinoma and breast cancer is discussed. Two possible forms of radiation induced changes are described, namely: classical radiation pneumonitis (RP) terminating with lung fibrosis circumscribed in the radiation zone, and sporadic RP giving rise to bilateral lymphatic alveolitis and manifestations outside the irradiation field. Attention is called to the fact that chemotherapy augments the risk of toxic lung damage occurrence. A number of markers for early RP diagnosis, including lactate dehydrogenase activity, KL-6, procollagen III, transforming growth factor β, C-reactive protein and partial oxygen pressure are listed. Therapeutic possibilities in coping with RP and pulmonary fibrosis are assayed. Apart from the standard therapeutic approach using corticosteroids and azatioprin, ideas are set forth concerning the application of some antioxidants, angiotensin converting enzyme inhibitors and γ-interferon. It is pointed out that radiation pneumonitis and pulmonary fibrosis treatment has an essential practical bearing on life expectancy and quality of life in a great number of cancer patients. (author)

  1. Radiotherapy of breast fibrosis

    International Nuclear Information System (INIS)

    Heibel, J.H.

    1979-01-01

    In a retrospective study radiotherapy of breast fibrosis in hormone-treated men with histologically confirmed prostate carcinoma was examined. 10 patients had received hormones even before irradiation, 113 obtained hormone administration only after irradiation. The objective size of the glandular body and the overall size of the breast were measured with a special method developed by the author. 46 patients indicated complaints. With hypertrophic mamma and hypertrophic mamilla in 67 examined patients, 127 different symptoms resulted in total. Four patients of the group who had obtained hormones before irradiation, suffered from subjective symptoms. It resulted that radiotherapy of breast fibrosis carried out during hormone treatment is no gynecomastia prophylaxis, that already existent mamma hypertrophies are irreversible, but that existent sensations were notably reduced within 6 months after irradiation therapy. These results indicate the necessity of a radiotherapy of the mamma fibrosis before the hormone treatment is begun. Particularly in cases of higher operative risks, also the possibility of preferring radiotherapy to mastectomy should be fully utilized, in view of adequate or even better therapeutic results. (orig./MG) [de

  2. Serum markers of liver fibrosis

    DEFF Research Database (Denmark)

    Veidal, Sanne Skovgård; Bay-Jensen, Anne-Christine; Tougas, Gervais

    2010-01-01

    -epitopes, may be targeted for novel biochemical marker development in fibrosis. We used the recently proposed BIPED system (Burden of disease, Investigative, Prognostic, Efficacy and Diagnostic) to characterise present serological markers. METHODS: Pubmed was search for keywords; Liver fibrosis, neo......, a systematic use of the neo-epitope approach, i.e. the quantification of peptide epitopes generated from enzymatic cleavage of proteins during extracellular remodeling, may prove productive in the quest to find new markers of liver fibrosis....

  3. Estudio del puesto de trabajo M16

    OpenAIRE

    Palmero Martín, Juan José

    2015-01-01

    El objetivo fundamental del trabajo presentado en esta memoria, consiste en la realización con éxito de la formación completa para el oficio de Técnico en Organización Industrial en la empresa Michelin. Dicha formación consiste en una serie de módulos teóricos impartidos por la Escuela de Organización Industrial, que se completan con un ejercicio práctico, supervisado por esta escuela, que propiamente forma el contenido de esta memoria. Departamento de Organización de Empresas y Comerciali...

  4. Trabajo Fin de Máster

    OpenAIRE

    Adánez Climent, Ángela

    2015-01-01

    Treball Final del Màster Universitari en Psicologia del Treball, de les Organitzacions i en Recursos Humans (Pla de 2014) (Presencial). Codi: SBE013. Curs acadèmic 2014-2015 Durante las últimas décadas, la creciente globalización de la sociedad y de la economía, los fuertes desarrollos de la tecnología de la información y la comunicación y los cambios demográficos, sociales y culturales han producido importantes transformaciones en el mundo del trabajo, en las organizaciones y en ...

  5. La subjetividad de la sociedad de trabajo

    OpenAIRE

    Hinkelammert, Franz

    2005-01-01

    El ensayo tiene como propósito lanzar una llamada de atención crítica ante una serie de fenómenos de índole política, económica y social que se gestan actualmente en el orden mundial. Describe, de manera amplia, cómo la globalización alimentada por un nuevo capitalismo evolucionado y la burocracia de las trasnacionales socavan lasensibilidad social del trabajo, el núcleo de identidad cultural de los pueblos y la democracia, transformándolas en fraudulentas y marginales, a la vez que contempla...

  6. Imaging from cystic fibrosis

    International Nuclear Information System (INIS)

    Schmidt, H.; Posselt, H.G.

    2008-01-01

    Cystic fibrosis (CF) is the most frequent metabolic disorder with autosomal recessive inheritance in the Caucasian population. The gene defect is located on the long arm of chromosome 7. In Germany today, the actual median survival is 37 years. The genetic defect caused by chloride anion disturbances affects multiple body systems but the morbidity and mortality is due to lung disease. The secretion of highly viscous mucus promotes viral and bacterial pulmonary infections leading to airway obstruction and consecutive destruction of the lung parenchyma. This article will review and discuss both the clinical aspects of the disease and the diagnostic methods, referring in particular to new imaging strategies. (orig.)

  7. Visibilidad e invisibilidad: Acerca del trabajo y las mujeres

    OpenAIRE

    Collado,Patricia Alejandra

    2009-01-01

    La crisis del empleo conjuntamente con las teorías del fin del trabajo, pusieron en discusión la centralidad del trabajo. Frente a esta situación, se observa que los debates en torno al trabajo en general (sus esferas productivas y reproductivas), su vinculación con el empleo y las formas visibles e invisibles de realizarlo han sido abordadas por una de las tradiciones más negadas del pensamiento social: el feminismo. Esta corriente intentó disputar el sentido sobre el trabajo y el no-trabajo...

  8. Idiopathic pulmonary fibrosis.

    Science.gov (United States)

    Xaubet, Antoni; Ancochea, Julio; Molina-Molina, María

    2017-02-23

    Idiopathic pulmonary fibrosis is a fibrosing interstitial pneumonia associated with the radiological and/or histological pattern of usual interstitial pneumonia. Its aetiology is unknown, but probably comprises the action of endogenous and exogenous micro-environmental factors in subjects with genetic predisposition. Its diagnosis is based on the presence of characteristic findings of high-resolution computed tomography scans and pulmonary biopsies in absence of interstitial lung diseases of other aetiologies. Its clinical evolution is variable, although the mean survival rate is 2-5 years as of its clinical presentation. Patients with idiopathic pulmonary fibrosis may present complications and comorbidities which modify the disease's clinical course and prognosis. In the mild-moderate disease, the treatment consists of the administration of anti-fibrotic drugs. In severe disease, the best therapeutic option is pulmonary transplantation. In this paper we review the diagnostic and therapeutic aspects of the disease. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  9. Nephrogenic systemic fibrosis

    International Nuclear Information System (INIS)

    Samtleben, W.

    2007-01-01

    A scleromyxedema-like disease was recognized in 1997. In 2000 this disorder was first published and termed nephrogenic fibrosing dermopathy because all patients had advanced renal failure. In 2006 it was discovered that the patients had a history of a preceding contrast-enhanced magnetic resonance imaging (MRI). All patients had acute or chronic severe renal insufficiency with a glomerular filtration rate (GFR) 2 . So far a total of about 215 patients with this new skin disorder have been reported to international registries. The skin thickening has a typical histology and begins in the peripheral extremities and progresses proximally, including also the abdominal wall and the head in some patients. NSF involves not only the skin, but also the muscles and other organs (e.g., lungs, heart, eyes) in some patients. Therefore the term nephrogenic systemic fibrosis (NSF) was introduced. Skin fibrosis and sclerosis are usually progressive with disabling contractures of involved joints (knees, hands, feet). NSF may be lethal in up to 28% of patients. Spontaneous remissions are rare. No generally accepted treatment is available. So far, the pathogenesis is not well understood. One hypothesis supposes a role of gadolinium liberated from the contrast agents. As patients with acute or chronic advanced renal failure (GFR 2 ) including those with hepatorenal dysfunctions are at high risk to develop NSF after exposure to gadolinium-based contrast agents, contrast-enhanced MRI should be avoided in this group and alternative diagnostic procedures should be used whenever possible. (orig.) [de

  10. Thoracic periaortal fibrosis and Ormond's disease

    International Nuclear Information System (INIS)

    Kacl, G.M.; Bino, M.; Salomon, F.; Risti, B.; Marincek, B.

    1995-01-01

    Two cases of thoracic periaortal fibrosis as a manifestation of retroperitoneal fibrosis (Ormond's disease) are shown on CT and MRI. Thoracic periaortal fibrosis can result in an inflammatory aneurysmo with chronic dissection. Manifestation of thoracic periaortal fibrosis may typically occur intermittently over decades. (orig.) [de

  11. Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy

    Science.gov (United States)

    2014-01-01

    Background Fibrosis, an excessive collagen accumulation, results in scar formation, impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies, including the lethal Duchenne muscular dystrophy (DMD), which remains incurable. Substitution of muscle by fibrotic tissue also complicates gene/cell therapies for DMD. Yet, no optimal models to study muscle fibrosis are available. In the widely used mdx mouse model for DMD, extensive fibrosis develops in the diaphragm only at advanced adulthood, and at about two years of age in the ‘easy-to-access’ limb muscles, thus precluding fibrosis research and the testing of novel therapies. Methods We developed distinct experimental strategies, ranging from chronic exercise to increasing muscle damage on limb muscles of young mdx mice, by myotoxin injection, surgically induced trauma (laceration or denervation) or intramuscular delivery of profibrotic growth factors (such as TGFβ). We also extended these approaches to muscle of normal non-dystrophic mice. Results These strategies resulted in advanced and enhanced muscle fibrosis in young mdx mice, which persisted over time, and correlated with reduced muscle force, thus mimicking the severe DMD phenotype. Furthermore, increased fibrosis was also obtained by combining these procedures in muscles of normal mice, mirroring aberrant repair after severe trauma. Conclusions We have developed new and improved experimental strategies to accelerate and enhance muscle fibrosis in vivo. These strategies will allow rapidly assessing fibrosis in the easily accessible limb muscles of young mdx mice, without necessarily having to use old animals. The extension of these fibrogenic regimes to the muscle of non-dystrophic wild-type mice will allow fibrosis assessment in a wide array of pre-existing transgenic mouse lines, which in turn will facilitate understanding the mechanisms of fibrogenesis. These strategies should improve our ability to combat fibrosis

  12. Gastrointestinal Manifestations of Cystic Fibrosis

    Science.gov (United States)

    2016-01-01

    Cystic fibrosis has historically been considered a pulmonary disease, but with the increasing life expectancy of these patients, gastrointestinal manifestations are becoming more important. Furthermore, nutritional status is closely linked to pulmonary function and, thus, overall mortality. This article discusses gastrointestinal manifestations (which involve nutritional, pancreatic, hepatobiliary, and, in particular, gastrointestinal tract issues) of cystic fibrosis as well as management of the disease. In addition, the article discusses studies that have been critical to our understanding of gastrointestinal manifestations of cystic fibrosis. PMID:27330503

  13. Nephrogenic systemic fibrosis.

    LENUS (Irish Health Repository)

    Kennedy, C

    2010-11-05

    Nephroaenic systemic fibrosis (NSF) is a potentiallv fatal dermatiological condition found exclusively in patients with advanced renal I failure. There is minimal literature regarding the epidemiology and outcomes of patients with NSF in Ireland. A retrospective chart review was performed for all patients with NSF in Ireland. Ireland\\'s experience with the disease was examined in light of international reports. There have been three cases of NSF in Ireland; an area which serves 1915 dialysis patients--giving a point prevalence among Irish end-stage kidney disease patients of 0.002. There was a large variation in disease severity between the three patients. All three patients had significant exposure to gadolinium chelate. Caution with gadolinium administration must be exercised in patients with advanced renal failure.

  14. Profile of cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Mona M. El-Falaki

    2014-09-01

    Full Text Available It was generally believed that Cystic fibrosis (CF is rare among Arabs; however, the few studies available from Egypt and other Arabic countries suggested the presence of many undiagnosed patients. The aim of the present study was to determine the frequency of CF patients out of the referred cases in a single referral hospital in Egypt. A total of 100 patients clinically suspected of having CF were recruited from the CF clinic of the Allergy and Pulmonology Unit, Children’s Hospital, Cairo University, Egypt, throughout a 2 year period. Sweat chloride testing was done for all patients using the Wescor macroduct system for collection of sweat. Quantitative analysis for chloride was then done by the thiocyanate colorimetric method. Patients positive for sweat chloride (⩾60 mmol/L were tested for the ΔF508 mutation using primer specific PCR for cystic fibrosis transmembrane conductance regulator (CFTR gene. Thirty-six patients (36% had a positive sweat chloride test. The main clinical presentations in patients were chronic cough in 32 (88.9%, failure to thrive in 27 (75%, steatorrhea in 24 (66.7%, and hepatobiliary involvement in 5 (13.9%. Positive consanguinity was reported in 50% of CF patients. Thirty-two patients were screened for ΔF508 mutation. Positive ΔF508 mutation was detected in 22 (68.8% patients, 8 (25% were homozygous, 14 (43.8% were heterozygous, and 10 (31.3% tested were negative. CF was diagnosed in more than third of patients suspected of having the disease on clinical grounds. This high frequency of CF among referred patients indicates that a high index of suspicion and an increasing availability of diagnostic tests lead to the identification of a higher number of affected individuals.

  15. Radiotherapy and pulmonary fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Sone, S; Miyata, Y; Tachiiri, H [Osaka Univ. (Japan). Faculty of Medicine

    1975-04-01

    Clinical findings of radiation pneumonitis and pulmonary fibrosis were outlined, and the relationship between occurence of these disorders and radiotherapy, clinical findings and X-ray picture were studied. Standard radiation dose as cell lethal response of carcinoma of the lung were 4,500 to 5,500 rad in 4 to 5.5 weeks in undifferentiated carcinoma, 6,000 to 7,000 rad in 6 to 7 weeks in squamous cell carcinoma, 7,000 to 9,000 rad in 7 to 9 weeks in adenocarcinoma, 4,500 to 5,000 rad in 4 to 5 weeks in the large sized cancer of the esophagus, 6,500 to 7,000 rad in 5 to 7 weeks in the small sized cancer of the esophagus, and irradiation of these amount of dose caused hazards in pulmonary function. Pathological and clinical findings of pulmonary hazards within 6 month period after irradiation, factors causing them and changes in X-ray pictures before and after irradiation were observed and discussed in clinical cases: the case of breast cancer in which 3,000 R/6 times/18 days of 5.5 MeV Liniac electron was irradiated to the chest wall, and the case of pulmonary cancer in which 5,000 rad/25 times/34 days of 6 MeV Liniac X-ray was irradiated in opposite 2 ports radiation beam treatment. The former revealed alveolar lesion and interlobular pleuritis at 4 month later, and remarkable lesion of pulmonary fibrosis was followed at 9 month after radiotherapy. The later developed radiation pneumonitis 1 month after radiotherapy, of which lesion extended to the upper part by 3 months later, and cancer recurred 6.5 month later.

  16. Adicci?n al trabajo en el contexto Colombiano

    OpenAIRE

    Torres Hern?ndez, Eliana Carolina

    2016-01-01

    Este estudio aborda el fen?meno de la Adicci?n al trabajo (AT) en el contexto de los sistemas de producci?n y de los escenarios del trabajo en Colombia como un pa?s de econom?a emergente, donde el trabajo hace parte esencial de la cultura, es considerado un valor central de la sociedad y un medio para alcanzar la movilidad social y reducir las desventajas sociales propias de este tipo de econom?as. De modo que, el trabajo es esencial y determinante en la calidad de vida de las personas por su...

  17. Effect of iron, taurine and arginine on rat hepatic fibrosis

    International Nuclear Information System (INIS)

    Song Liangwen; Wang Dewen; Cui Xuemei

    1997-01-01

    Objective: The promotion role of iron on pathogenesis of hepatic fibrosis and the protective role of taurine and L-arginine against hepatic fibrosis were studied. Method: The model of rat radiation hepatic fibrosis was used. Experimental rats were divided into 0 Gy, 30 Gy, 30 Gy + iron, 30 Gy + taurine and 30 Gy + L-arginine groups. Serum iron, liver tissue hydroxyproline (Hyp) and malondialdehyde (MDA) were measured one and three months respectively after irradiation of hepatic tissue, production and distribution characteristics of hepatic tissue type I and III collagen were observed with a polarizing microscope. Results: Administration of iron agent could significantly increase hepatic tissue MDA content and serum iron concentration, one month after irradiation, hepatic tissue Hyp in 30 Gy + iron group began to increase, and collagen in hepatic tissue obviously increased. Taurine and L-arginine could reduce serum iron concentration and decrease production of hepatic fissure Hyp. Conclusion: Exogenous iron agent could promote early development of radiation hepatic fibrosis; taurine and arginine could diminish pathologic alteration of hepatic fibrosis to a certain extent

  18. Therapeutic targets in liver fibrosis.

    Science.gov (United States)

    Fallowfield, Jonathan A

    2011-05-01

    Detailed analysis of the cellular and molecular mechanisms that mediate liver fibrosis has provided a framework for therapeutic approaches to prevent, slow down, or even reverse fibrosis and cirrhosis. A pivotal event in the development of liver fibrosis is the activation of quiescent hepatic stellate cells (HSCs) to scar-forming myofibroblast-like cells. Consequently, HSCs and the factors that regulate HSC activation, proliferation, and function represent important antifibrotic targets. Drugs currently licensed in the US and Europe for other indications target HSC-related components of the fibrotic cascade. Their deployment in the near future looks likely. Ultimately, treatment strategies for liver fibrosis may vary on an individual basis according to etiology, risk of fibrosis progression, and the prevailing pathogenic milieu, meaning that a multiagent approach could be required. The field continues to develop rapidly and starts to identify exciting potential targets in proof-of-concept preclinical studies. Despite this, no antifibrotics are currently licensed for use in humans. With epidemiological predictions for the future prevalence of viral, obesity-related, and alcohol-related cirrhosis painting an increasingly gloomy picture, and a shortfall in donors for liver transplantation, the clinical urgency for new therapies is high. There is growing interest from stakeholders keen to exploit the market potential for antifibrotics. However, the design of future trials for agents in the developmental pipeline will depend on strategies that enable equal patient stratification, techniques to reliably monitor changes in fibrosis over time, and the definition of clinically meaningful end points.

  19. Targeting Interleukin-13 with Tralokinumab Attenuates Lung Fibrosis and Epithelial Damage in a Humanized SCID Idiopathic Pulmonary Fibrosis Model

    Science.gov (United States)

    Zhang, Huilan; Oak, Sameer R.; Coelho, Ana Lucia; Herath, Athula; Flaherty, Kevin R.; Lee, Joyce; Bell, Matt; Knight, Darryl A.; Martinez, Fernando J.; Sleeman, Matthew A.; Herzog, Erica L.; Hogaboam, Cory M.

    2014-01-01

    The aberrant fibrotic and repair responses in the lung are major hallmarks of idiopathic pulmonary fibrosis (IPF). Numerous antifibrotic strategies have been used in the clinic with limited success, raising the possibility that an effective therapeutic strategy in this disease must inhibit fibrosis and promote appropriate lung repair mechanisms. IL-13 represents an attractive target in IPF, but its disease association and mechanism of action remains unknown. In the present study, an overexpression of IL-13 and IL-13 pathway markers was associated with IPF, particularly a rapidly progressive form of this disease. Targeting IL-13 in a humanized experimental model of pulmonary fibrosis using tralokinumab (CAT354) was found to therapeutically block aberrant lung remodeling in this model. However, targeting IL-13 was also found to promote lung repair and to restore epithelial integrity. Thus, targeting IL-13 inhibits fibrotic processes and enhances repair processes in the lung. PMID:24325475

  20. Idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Noble Paul W

    2008-03-01

    Full Text Available Abstract Idiopathic pulmonary fibrosis (IPF is a non-neoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known provocation. IPF is a rare disease which affects approximately 5 million persons worldwide. The prevalence is estimated to be slightly greater in men (20.2/100,000 than in women (13.2/100,000. The mean age at presentation is 66 years. IPF initially manifests with symptoms of exercise-induced breathless and dry coughing. Auscultation of the lungs reveals early inspiratory crackles, predominantly located in the lower posterior lung zones upon physical exam. Clubbing is found in approximately 50% of IPF patients. Cor pulmonale develops in association with end-stage disease. In that case, classic signs of right heart failure may be present. Etiology remains incompletely understood. Some environmental factors may be associated with IPF (cigarette smoking, exposure to silica and livestock. IPF is recognized on high-resolution computed tomography by peripheral, subpleural lower lobe reticular opacities in association with subpleural honeycomb changes. IPF is associated with a pathological lesion known as usual interstitial pneumonia (UIP. The UIP pattern consists of normal lung alternating with patches of dense fibrosis, taking the form of collagen sheets. The diagnosis of IPF requires correlation of the clinical setting with radiographic images and a lung biopsy. In the absence of lung biopsy, the diagnosis of IPF can be made by defined clinical criteria that were published in guidelines endorsed by several professional societies. Differential diagnosis includes other idiopathic interstitial pneumonia, connective tissue diseases (systemic sclerosis, polymyositis, rheumatoid arthritis, forme fruste of autoimmune disorders, chronic hypersensitivity pneumonitis and other environmental (sometimes occupational exposures. IPF is typically progressive and leads to significant

  1. Trabajo infantil : Análisis del trabajo infantil en el MERCOSUR

    OpenAIRE

    Portillo, Claudia Eugenia

    2004-01-01

    Hay en el mundo unos 250 millones de niños y niñas de entre 5 y 14 años que trabajan. Así lo han afirmado y probado diferentes organismos internacionales, entre ellos UNICEF y OIT, a más de los reconocimientos parciales efectuados por los diferentes Estados involucrados y las organizaciones no gubernamentales locales. Este es justamente el tema que se intentará analizar a lo largo de este trabajo, interdisciplinariamente desde la perspectiva de las relaciones internacionales y el Derecho Inte...

  2. Efecto de un trabajo de técnica de desplazamiento y de un trabajo de cuestas sobre el desplazamiento en defensa y la capacidad de salto en voleibol

    Directory of Open Access Journals (Sweden)

    Vicente Ávila Gandía

    2010-09-01

    Full Text Available El objetivo del presente estudio fue comprobar el efecto de un trabajo de técnica de desplazamiento combinado o no con un trabajo de cuestas sobre la capacidad de desplazamiento general y específico y sobre la capacidad de alcance en jugadores de voleibol en periodo de formación. La muestra objeto de estudio fueron 36 jugadores de voleibol en formación (grupo A estuvo formado por 18 jugadores masculinos, y grupo B y C por nueve jugadoras cada uno. Se realizó un diseño cuasi-experimental intersujeto con una prueba pre, post, y re-test. La variable independiente fue el tipo de trabajo realizado para mejorar la capacidad de desplazamiento (nueve sesiones. Se distinguieron dos niveles de intervención: a realización de un trabajo de desplazamientos específicos (grupos A y B; y b realización de un trabajo de desplazamientos específicos y de un trabajo de fuerza en cuestas ascendentes (grupo C. Las variables dependientes fueron: la técnica y el tiempo de desplazamiento en bloqueo, y en defensa en campo, el tiempo en realización del test de 9-3-3-9, y la altura de alcance en un salto con y sin carrera de aproximación. El trabajo de técnica de desplazamientos mejora la calidad de ejecución de los desplazamientos específicos. En categoría masculina, el trabajo de técnica de desplazamiento mejora los tiempos de ejecución de los desplazamientos genéricos y de los desplazamientos específicos. En categoría femenina, el trabajo de técnica de desplazamiento no mejoró los tiempos de ejecución de los desplazamientos genéricos y de los desplazamientos específicos. En categoría femenina, el trabajo de técnica de desplazamiento realizado de forma conjunta con el trabajo de cuestas parece mejorar los tiempos de ejecución de los desplazamientos genéricos y de los desplazamientos específicos. El trabajo de técnica de desplazamiento con o sin el trabajo de cuestas no mejora la capacidad de alcance de los jugadores.

  3. Breakdown in Breathing: The Complexities of Cystic Fibrosis

    Science.gov (United States)

    ... Healthier Lungs in Kids Wise Choices Living with Cystic Fibrosis In between checkups, practice good self-care and ... Links What Is Cystic Fibrosis? Learning About Cystic Fibrosis NIH Cystic Fibrosis Fact Sheet Genetic and Rare Diseases Information ...

  4. Pulmonary CCR2+CD4+ T cells are immune regulatory and attenuate lung fibrosis development.

    Science.gov (United States)

    Milger, Katrin; Yu, Yingyan; Brudy, Eva; Irmler, Martin; Skapenko, Alla; Mayinger, Michael; Lehmann, Mareike; Beckers, Johannes; Reichenberger, Frank; Behr, Jürgen; Eickelberg, Oliver; Königshoff, Melanie; Krauss-Etschmann, Susanne

    2017-11-01

    Animal models have suggested that CCR2-dependent signalling contributes to the pathogenesis of pulmonary fibrosis, but global blockade of CCL2 failed to improve the clinical course of patients with lung fibrosis. However, as levels of CCR2 + CD4 + T cells in paediatric lung fibrosis had previously been found to be increased, correlating with clinical symptoms, we hypothesised that distinct CCR2 + cell populations might either increase or decrease disease pathogenesis depending on their subtype. To investigate the role of CCR2 + CD4 + T cells in experimental lung fibrosis and in patients with idiopathic pulmonary fibrosis and other fibrosis. Pulmonary CCR2 + CD4 + T cells were analysed using flow cytometry and mRNA profiling, followed by in silico pathway analysis, in vitro assays and adoptive transfer experiments. Frequencies of CCR2 + CD4 + T cells were increased in experimental fibrosis-specifically the CD62L - CD44 + effector memory T cell phenotype, displaying a distinct chemokine receptor profile. mRNA profiling of isolated CCR2 + CD4 + T cells from fibrotic lungs suggested immune regulatory functions, a finding that was confirmed in vitro using suppressor assays. Importantly, adoptive transfer of CCR2 + CD4 + T cells attenuated fibrosis development. The results were partly corroborated in patients with lung fibrosis, by showing higher percentages of Foxp3 + CD25 + cells within bronchoalveolar lavage fluid CCR2 + CD4 + T cells as compared with CCR2 - CD4 + T cells. Pulmonary CCR2 + CD4 + T cells are immunosuppressive, and could attenuate lung inflammation and fibrosis. Therapeutic strategies completely abrogating CCR2-dependent signalling will therefore also eliminate cell populations with protective roles in fibrotic lung disease. This emphasises the need for a detailed understanding of the functions of immune cell subsets in fibrotic lung disease. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights

  5. La red sobre trabajo infantil peligroso (Red Tip

    Directory of Open Access Journals (Sweden)

    Walter Varillas

    2003-01-01

    Full Text Available En el mundo, aproximadamente 351.7 millones de niños entre 5 y 17 años realizaban algún tipo de actividad económica, de ellos 170.5 millones (48.5% realizaban algún tipo de trabajo considerado peligroso. Un alto porcentaje se encuentra en la agricultura, otros en minas, manufacturas, ladrilleras, predominantemente en la economía informal. El Convenio 138 (cobre la edad mínima de admisión en el empleo de la OIT y el Convenio 182 (sobre las peores formas de trabajo infantil, definen como trabajo infantil peligroso el que puede afectar la salud, seguridad y moralidad de los menores. Estudios específicos sobre los menores muestran su susceptibilidad particular frente a los riesgos laborales, aumentando la peligrosidad para su normal desarrollo y crecimiento: "los niños no son adultos pequeños". Los profesionales de la seguridad y salud en el trabajo pueden colaborar con los profesionales y las organizaciones especializadas en el trabajo infantil, en la definición y caracterización de lo que significa el trabajo infantil peligroso. Para ello se ha conformado la Red sobre Trabajo Infantil Peligroso (Red TIP, con la finalidad de articular estos dos espacios, orientados a eliminar el trabajo infantil peligroso y rescatar al menor y devolverle la oportunidad de sonreír ahora y en el futuro.

  6. Expression and distribution of connexin 32 in rat liver with experimentally induced fibrosis Expressão e distribuição da conexina 32 em fígados de ratos com fibrose induzida experimentalmente

    Directory of Open Access Journals (Sweden)

    Alexandro dos S. Rodrigues

    2009-04-01

    Full Text Available The connexin 32 (Cx32 is a protein that forms the channels that promote the gap junction intercellular communication (GJIC in the liver, allowing the diffusion of small molecules through cytosol from cell-to-cell. Hepatic fibrosis is characterized by a disruption of normal tissue architeture by cellular lesions, and may alter the GJIC. This work aimed to study the expression and distribution of Cx32 in liver fibrosis induced by the oral administration of dimethylnitrosamine in female Wistar rats. The necropsy of the rats was carried out after five weeks of drug administration. They presented a hepatic fibrosis state. Sections from livers with fibrosis and from control livers were submitted to immunohistochemical, Real Time-PCR and Western-Blot analysis to Cx32. In fibrotic livers the Cxs were diffusely scattered in the cytoplasm, contrasting with the control livers, where the Cx32 formed junction plaques at the cell membrane. Also it was found a decrease in the gene expression of Cx32 without reduction in the protein quantity when compared with controls. These results suggest that there the mechanism of intercellular communication between hepatocytes was reduced by the fibrotic process, which may predispose to the occurrence of a neoplastic process, taken in account that connexins are considered tumor suppressing genes.A conexina 32 (Cx32 é uma proteína que constitui os canais que promovem as comunicações intercelulares via junções comunicantes (CIJC no fígado, permitindo difusão de pequenas moléculas citoplasmáticas de uma célula à outra. A fibrose hepática caracteriza-se pela alteração da arquitetura normal do fígado e podem alterar as CIJCs. O objetivo deste trabalho foi estudar a expressão e distribuição de Cx32 na fibrose hepática. O objetivo do presente trabalho foi estudar a expressão e distribuição da Cx32 em fígados com fibrose induzida pela administração oral de dimetilnitrosamina em fêmeas de ratos Wistar. A

  7. Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model

    Directory of Open Access Journals (Sweden)

    Arianne van Koppen

    2018-01-01

    Conclusions: An early predictive molecular signature was identified that marked the active profibrotic process before histopathologic fibrosis becomes manifest. Early detection of the onset of NASH and fibrosis enables identification of novel blood-based biomarkers to stratify patients at risk, development of new therapeutics, and help shorten (preclinical experimental time frames.

  8. Fibrosis imaging : Current concepts and future directions

    NARCIS (Netherlands)

    Baues, Maike; Dasgupta, Anshuman; Ehling, Josef; Prakash, Jai; Boor, Peter; Tacke, Frank; Kiessling, Fabian; Lammers, Twan

    2017-01-01

    Fibrosis plays an important role in many different pathologies. It results from tissue injury, chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized by the excessive deposition of extracellular matrix components. Biopsies are routinely employed for fibrosis

  9. Pathological assessment of liver fibrosis regression

    Directory of Open Access Journals (Sweden)

    WANG Bingqiong

    2017-03-01

    Full Text Available Hepatic fibrosis is the common pathological outcome of chronic hepatic diseases. An accurate assessment of fibrosis degree provides an important reference for a definite diagnosis of diseases, treatment decision-making, treatment outcome monitoring, and prognostic evaluation. At present, many clinical studies have proven that regression of hepatic fibrosis and early-stage liver cirrhosis can be achieved by effective treatment, and a correct evaluation of fibrosis regression has become a hot topic in clinical research. Liver biopsy has long been regarded as the gold standard for the assessment of hepatic fibrosis, and thus it plays an important role in the evaluation of fibrosis regression. This article reviews the clinical application of current pathological staging systems in the evaluation of fibrosis regression from the perspectives of semi-quantitative scoring system, quantitative approach, and qualitative approach, in order to propose a better pathological evaluation system for the assessment of fibrosis regression.

  10. Computed tomography of cystic pancreatic fibrosis

    International Nuclear Information System (INIS)

    Brachlow, M.; Zaunbauer, W.; Haertel, M.

    1984-01-01

    The computer tomographic appearances of atrophic and lipomatous degeneration of the pancreas in cystic pancreatic fibrosis are described. CT exploration of the pancreas in recommended, particularly in differential diagnostic aspects of cystic fibrosis. (orig.) [de

  11. La intensificación del trabajo en España (2007-2011: trabajo en equipo y flexibilidad

    Directory of Open Access Journals (Sweden)

    Francisco Javier Pinilla García

    2017-01-01

    Full Text Available En este artículo analizamos la relación entre el proceso de intensificación del trabajo y la flexibilidad organizacional. Específicamente, nos centramos en el trabajo en equipo, como estrategia organizacional considerada emblemática de las organizaciones flexibles y eficientes. Analizamos la relación entre trabajo en equipo, intensidad y estrés, explotando los datos de las Encuestas Nacionales de Condiciones de Trabajo. A partir de los resultados obtenidos, proponemos incorporar el análisis de la intensidad del trabajo en el ámbito del diálogo social y en la prevención de riesgos laborales.

  12. Nephrogenic systemic fibrosis

    Directory of Open Access Journals (Sweden)

    Bhushan Madke

    2011-01-01

    Full Text Available Nephrogenic systemic fibrosis (NSF is a relatively new fibrosing disorder which has caught the attention of various specialities in the past decade. NSF is an extremely disabling and often painful condition, affecting up to 13% of the individuals with chronic kidney disease. The administration of a gadolinium chelate contrast agent has been reported to induce the development of NSF, particularly in patients who have acute or chronic renal disease with a glomerular filtration rate (GFR lower than 30-mL/min/1.73 m 2 and in those with acute renal insufficiency. Mass spectroscopy studies have demonstrated particles of gadolinium in the lesional tissue. The exact pathogenesis of this curious sclerosing condition is unknown. The role of the aberrant targeting of ′circulating fibrocytes′ to the peripheral tissues and viscera has been hypothesized. NSF has distinct clinicopathological features in the setting of renal failure and needs to be looked upon as a new entity on the block. The condition is characterized by irregular indurated plaques, with amoeba-like projections and islands of sparing, chiefly on the trunk and extremities. Flexion contractures of fingers, knees, and elbow joints are known to occur in advanced cases of NSF. The course is frequently associated with painful episodes and loss of ambulation. Histopathology shows haphazard arrangement of thickened bundles of collagen, varying amount of mucin, and increased population of fibroblast-like cells in the dermis. Immunohistochemistry shows increased deposition of type-I procollagen and CD 34+ cells having fibroblastic activity. The condition is refractory to treatment with corticosteroids and immunosuppressive agents. Various modalities of therapy such as UVA1 phototherapy, imatinib mesylate, photodynamic therapy, plasmapheresis, extracorporeal photochemotherapy, and high-dose intravenous immunoglobulin have shown a moderate degree of improvement in skin thickness scores. A prudent

  13. Cystic fibrosis in adults

    Directory of Open Access Journals (Sweden)

    C. Damas

    2007-05-01

    Full Text Available The authors reviewed adult cystic fibrosis patients followed in the Pulmonology Unit from 1994-2004 (n = 8, five female and three male, aged 20-34 years old (median = 27 years. Patients were diagnosed at 18 months - 31 years old by sweat testing (positive in six patients and genotyping (four patients homozygous for ΔF508 mutation.Respiratory involvement was characterised by sinusitis and bronchiectasis. Pulmonary involvement was accompanied by functional abnormalities and gas exchange impairment in the majority of the patients. Bronchial tree was colonised permanently in five patients: Pseudomonas aeruginosa in four and Staphilococcus aureus in four (three patients affected by both agents simultaneously.The main causes of exacerbation were respiratory infections and haemoptysis.Non-respiratory involvement was variable. Four patients had digestive involvement (one with hepatic cirrhosis, one had renal failure and only one had a sperm count to document infertility. Four patients had osteopaenia.Treatment included chest physiotherapy, bronchodilators, dornase alfa, mucolytics, digestive enzymes, vitamins, antibiotics and oxygen therapy.At review, one had left follow-up, one had died, one was awaiting lung transplant and the others evidenced no difference in clinical characteristics.In this group of patients the severity of the pulmonary disease was not related to a late diagnosis. It can be explained by the diversity of cystic fibrosis presentation in adults Resumo: Os autores efectuaram uma revisão de doentes adultos com fibrose quística (FQ, seguidos na consulta de Pneumologia no período de 1994-2004 (n = 8: cinco mulheres e três homens, com idades compreendidas entre 20 e 34 anos (mediana  =  27 anos, cuja idade de diagnóstico variou entre os 18 meses e os 31 anos.O diagnóstico foi obtido por prova de suor (positiva em seis doentes e estudo genético (homozigotia para a mutação ΔF508 em

  14. Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions

    Science.gov (United States)

    Krieg, Thomas; Abraham, David; Lafyatis, Robert

    2007-01-01

    Fibrosis, characterized by excessive extracellular matrix accumulation, is a common feature of many connective tissue diseases, notably scleroderma (systemic sclerosis). Experimental studies suggest that a complex network of intercellular interactions involving endothelial cells, epithelial cells, fibroblasts and immune cells, using an array of molecular mediators, drives the pathogenic events that lead to fibrosis. Transforming growth factor-β and endothelin-1, which are part of a cytokine hierarchy with connective tissue growth factor, are key mediators of fibrogenesis and are primarily responsible for the differentiation of fibroblasts toward a myofibroblast phenotype. The tight skin mouse (Tsk-1) model of cutaneous fibrosis suggests that numerous other genes may also be important. PMID:17767742

  15. Trabajo colaborativo, espacio digital y e-learning

    OpenAIRE

    Redondo Casado, Félix

    2009-01-01

    El EEES exige a los profesores el trabajo con las nuevas tecnologías de la información y la comunicación, que posibilitan la informática y las redes. La hipótesis principal del estudio es que el trabajo colaborativo se configura como un procedimiento atractivo y fructífero para crear el conocimiento entre profesor y alumnos. El siguiente trabajo, tras una introducción a este fenómeno hace una conceptualización del significado de lo colaborativo, así como de espacio digital (preferible a espac...

  16. Mujeres y mercado de trabajo del turismo alternativo en Veracruz

    Directory of Open Access Journals (Sweden)

    Isis Arlene Díaz-Carrión

    2013-01-01

    Full Text Available Resultado de su compromiso con una sustentabilidad social, el turismo alternativo es considerado una actividad para potenciar cambios en la tradicional división del trabajo. En esta investigación cualitativa se revisa la participación de las mujeres en el turismo alternativo del estado de Veracruz y se visibilizan segregaciones ocupacionales y simultaneidad en la realización de trabajo productivo- reproductivo y de cuidados. El enfoque de género se muestra como una herramienta potencial para observar el trabajo productivo de las mujeres y promover el acceso al espacio público y sus recursos.

  17. Los límites legales del trabajo nocturno

    OpenAIRE

    López-Quiñones García, Antonio

    2016-01-01

    El trabajo nocturno se articula y se define en función de dos conceptos: uno objetivo, el período nocturno, y otro subjetivo, el trabajador nocturno. Para la delimitación del trabajo nocturno, el Estatuto de los Trabajadores ofrece una definición objetiva y otra subjetiva. Por un lado, conforme a lo previsto en el artículo 36 de dicho cuerpo legal se considera trabajo nocturno el realizado entre las diez de la noche y las seis de la mañana; se trata de una definición objetiva en función del p...

  18. Trabajos en espacios confinados. Riesgos y medidas preventivas

    OpenAIRE

    Fernández, Sergio

    2012-01-01

    La ejecución de trabajos en espacios confinados resulta una necesidad en diversos sectores como por ejemplo en la industria química, redes de alcantarillado, construcción de barcos, en pozos,… con el fin desarrollar diversas tareas como limpiezas, inspecciones interiores, trabajos de pintura, reparaciones varias,… lo que implica la implantación de medidas especiales y rigurosas a planificar y llevar a cabo. Los riesgos que presentan la ejecución de estos trabajos en espacios confinados ...

  19. Trabajo social sanitario y daño cerebral adquirido

    OpenAIRE

    Ruiz-Prados Víbora, Lucía

    2014-01-01

    La figura del profesional del trabajo social sanitario, ocupa un puesto rezagado en la sociedad, cuyo desconocimiento ocasiona la pérdida de sus conocimientos aplicados a su trabajo. Este trabajo fundamenta, la razón de su utilidad e importancia. Por un lado, centrándose más específicamente en el ámbito de la sanidad, resaltando la figura del/la profesional en cuanto a la continuidad de cuidados ante el alta hospitalaria y, posteriormente, haciendo hincapié en todo lo que respe...

  20. Trabajo femenino, Empoderamiento y Bienestar de la Familia

    OpenAIRE

    Casique, Irene

    2004-01-01

    El objetivo que nos planteamos en este trabajo es examinar los posibles efectos que tanto el trabajo extra-doméstico femenino como el empoderamiento de la mujer puedan tener sobre dos aspectos particulares del bienestar familiar en México: la erradicación de la violencia hacia la mujer y la mayor participación de los hombres en el cuidado y crianza de los hijos.

  1. EVALUACIÓN ERGONÓMICA DEL PUESTO DE TRABAJO

    OpenAIRE

    Vázquez-Barandica, Mikel

    2012-01-01

    El objeto de la Evaluación Psicosocial es estimar y valorar la magnitud de aquellos riesgos asociados a las condiciones psicosociales de trabajo, existentes en el centro de trabajo de Sarriguren, todo ello con la finalidad última de aportar a la empresa la información adecuada para tomar las decisiones apropiadas sobre la necesidad de adoptar nuevas medidas y planificar adecuadamente la actividad preventiva

  2. LOS ROLES NO LABORALES Y EL ESTRES EN EL TRABAJO

    Directory of Open Access Journals (Sweden)

    Juan Guerrero

    2003-07-01

    Full Text Available Este análisis se ocupa de dimensiones esenciales de las personas vinculadas al mundo del trabajo: el “momento de trabajo†y el “momento de no-trabajoâ€. Se cotejan relaciones y procesos invariablemente presentes en el diario vivir de hombres y mujeres, pero que afectan su bienestar y desempeño ocupacional de manera distinta. Se trata de aspectos que convergen y se potencian para dar lugar a variados perfiles de vida laboral y extralaboral, a diferentes perfiles de salud y productividad. Estos son entre otros: los conocimientos y habilidades del individuo, sus condiciones de genero, sus expectativas ocupacionales, su estilo de vida, sus valores y patrones de crianza, su vulnerabilidad al estrés, sus estrategias de afrontamiento, las oportunidades de empleo, la diversidad de roles, el tiempo disponible para atenderlos, la naturaleza y disponibilidad de apoyo social. El concepto que orienta todo el análisis es el de “spillover†trabajo-familia, que corresponde a la permanente e inevitable “contaminación psicológica†de las circunstancias del trabajo sobre la vida familiar y viceversa. Se trata de un proceso connatural a la existencia de hombres y mujeres de la sociedad industrial y que invariablemente está presente para enriquecer o empobrecer el desempeño humano en, dentro o fuera del trabajo.

  3. El trabajo en Smith: valor o medida del valor?

    Directory of Open Access Journals (Sweden)

    Adolfo Rodríguez Herrera

    2016-12-01

    Este artículo revisa los conceptos desarrollados por Smith para formular su teoría del valor (valor, precio real y valor de  cambio. Nuestra interpretación de sus textos sobre el valor no coincide con la que tradicionalmente se ha hecho. De acuerdo con nuestra interpretación, no sería correcta la crítica de Ricardo y Marx a la posición de Smith sobre el papel del trabajo como medida de valor. Para estos autores, Smith no es consistente al proponer que el valor de una mercancía es definido o medido como la cantidad de trabajo necesaria para producirla y simultáneamente como la cantidad de trabajo que puede ser comprada por esta mercancía. Tratamos de demostrar que para Smith el trabajo tiene un doble papel –como fuente y como medida del valor–, y que a ello se debe la confusión generada por su uso de algunos términos: Smith propone el trabajo como una medida de valor porque lo concibe como una fuente de valor. Con esta interpretación queda claro, paradójicamente, que la teoría del valor trabajo de Smith corresponde sustancialmente con la que más tarde desarrollarán Ricardo y Marx.

  4. Nephrogenic Systemic Fibrosis in Denmark

    DEFF Research Database (Denmark)

    Elmholdt, Tina Rask; Olesen, Anne; J�rgensen, Bettina

    2013-01-01

    Nephrogenic systemic fibrosis is a debilitating and painful disorder with an increased stimulation of the connective tissue in the skin and systemic tissues. The disease is associated with exposure to gadolinium-based contrast agent used in magnetic resonance imaging in patients with renal...

  5. Radiation pericarditis and myocardial fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Westerhof, P W; van der Putte, S C.J.

    1976-06-01

    The case of a 45-yr-old man with constrictive pericarditis due to radiation for Hodgkin's disease is described. After pericardiectomy the clinical condition did not improve. At necropsy an extensive fibrosis of the myocardium especially located in the anterior part of the heart was found. The clinical consequences of this finding with respect to surgical treatment are briefly discussed.

  6. [Genetic counseling in cystic fibrosis].

    Science.gov (United States)

    Julia, S; Bieth, E

    2000-08-01

    Genetic counseling is an important part of health care in patients with cystic fibrosis or respiratory diseases associated with the CFTR (cystic fibrosis transmembrane conductance regulator) gene, including certain types of allergic bronchopulmonary aspergilloses or bronchial diseases (diffuse bronchiectasia). The basic goal is to provide patients with information on the transmission of cystic fibrosis and to asses the risk of recurrence. This risk is determined from molecular biology analyses examining the CFTR gene. Genotyping is the only means of screening for the heterozygous state, frequent in the French population (about 1/30). Because of the large number of mutated alleles not covered entirely by the genetic tests, there remains a question of probability expressed as a residual risk of a heterozygous state. A prenatal genotype diagnosis should be proposed to heterozygous couples who have a 25% risk of having a diseased child. Technically, this is almost always possible and the results are highly reliable. Nevertheless, there remains the risks related to sample taking and the ethical issue about which the patients must be informed. Management of these at risk couples who desire a child must be based on a multidisciplinary approach, particularly important when one of the parents has overt cystic fibrosis.

  7. Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis

    Science.gov (United States)

    Sharma, Amit; Khan, Md. Abdul Hye; Levick, Scott P.; Lee, Kin Sing Stephen; Hammock, Bruce D.; Imig, John D.

    2016-01-01

    Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions. The present study determined the ability of the most abundant EDP regioisomer, 19,20-EDP to reduce kidney injury in an experimental unilateral ureteral obstruction (UUO) renal fibrosis mouse model. Mice with UUO developed kidney tubular injury and interstitial fibrosis. UUO mice had elevated kidney hydroxyproline content and five-times greater collagen positive fibrotic area than sham control mice. 19,20-EDP treatment to UUO mice for 10 days reduced renal fibrosis with a 40%–50% reduction in collagen positive area and hydroxyproline content. There was a six-fold increase in kidney α-smooth muscle actin (α-SMA) positive area in UUO mice compared to sham control mice, and 19,20-EDP treatment to UUO mice decreased α-SMA immunopositive area by 60%. UUO mice demonstrated renal epithelial-to-mesenchymal transition (EMT) with reduced expression of the epithelial marker E-cadherin and elevated expression of multiple mesenchymal markers (FSP-1, α-SMA, and desmin). Interestingly, 19,20-EDP treatment reduced renal EMT in UUO by decreasing mesenchymal and increasing epithelial marker expression. Overall, we demonstrate that a novel omega-3 fatty acid metabolite 19,20-EDP, prevents UUO-induced renal fibrosis in mice by reducing renal EMT. PMID:27213332

  8. Obesity, metabolic dysfunction and cardiac fibrosis: pathophysiologic pathways, molecular mechanisms and therapeutic opportunities

    Science.gov (United States)

    Cavalera, Michele; Wang, Junhong; Frangogiannis, Nikolaos G

    2014-01-01

    Cardiac fibrosis is strongly associated with obesity and metabolic dysfunction and may contribute to the increased incidence of heart failure, atrial arrhythmias and sudden cardiac death in obese subjects. Our review discusses the evidence linking obesity and myocardial fibrosis in animal models and human patients, focusing on the fundamental pathophysiologic alterations that may trigger fibrogenic signaling, the cellular effectors of fibrosis and the molecular signals that may regulate the fibrotic response. Obesity is associated with a wide range of pathophysiologic alterations (such as pressure and volume overload, metabolic dysregulation, neurohumoral activation and systemic inflammation); their relative role in mediating cardiac fibrosis is poorly defined. Activation of fibroblasts likely plays a major role in obesity-associated fibrosis; however, inflammatory cells, cardiomyocytes and vascular cells may also contribute to fibrogenic signaling. Several molecular processes have been implicated in regulation of the fibrotic response in obesity. Activation of the Renin-Angiotensin-Aldosterone System, induction of Transforming Growth Factor-β, oxidative stress, advanced glycation end-products (AGEs), endothelin-1, Rho-kinase signaling, leptin-mediated actions and upregulation of matricellular proteins (such as thrombospondin-1) may play a role in the development of fibrosis in models of obesity and metabolic dysfunction. Moreover, experimental evidence suggests that obesity and insulin resistance profoundly affect the fibrotic and remodeling response following cardiac injury. Understanding the pathways implicated in obesity-associated fibrosis may lead to development of novel therapies to prevent heart failure and to attenuate post-infarction cardiac remodeling in obese patients. PMID:24880146

  9. EQUIPOS DE TRABAJO VIRTUAL: LOS DESAFÍOS DEL TRABAJO COMPARTIDO A DISTANCIA

    Directory of Open Access Journals (Sweden)

    Yaneth Rincón

    2008-11-01

    Full Text Available El propósito de este artículo consiste en describir cuáles son las dificultades que enfrenta el trabajo en equipo a distancia y proponer estrategias para hacerlos más efectivos. Se define el concepto de equipo virtual y se analizan las dificultades entre sus miembros bajo tres aspectos: a Brechas en el uso de las tecnologías de información y comunicación, b La comunicación, y c La coordinación. Se concluye que los equipos virtuales presentan dificultades muy similares a las de los equipos presenciales; no obstante, estas dificultades que pudieran ser incrementadas por lo impersonal del uso de tecnologías pueden ser superadas con el tiempo bajo un adecuado adiestramiento, una eficaz coordinación y una constante comunicación.

  10. Daniel Solano: "Me matan si no trabajo, y si trabajo me matan"

    Directory of Open Access Journals (Sweden)

    Jessica Visotsky

    2015-01-01

    Full Text Available Existe una creencia en el noroeste argentino que es la Leyenda del Familiar, esta leyenda que al parecer surgiría ligada al desarrollo industrial, nace y se desarrolla ligada a la instalación de los ingenios azucareros a fines del siglo XIX y principios del XX. En los mismos se llevó a cabo la explotación de miles y miles de trabajadores bajo condiciones inhumanas de trabajo y salarios miserables. El familiar era el perro del diablo o el diablo mismo, podía también adoptar formas de viborón, toro, burro, por lo general era un perro, negro, desprendía llamaradas de fuego por los ojos, tenía una fuerza descomunal en sus garras, con quién el patrón del ingenio o capataz había hecho un pacto: que saciaría su hambre con la entrega de un obrero por año, y éste le aseguraría prosperidad. En distintas situaciones un obrero podía encontrar la muerte, sea por accidentes, sea cayendo a una caldera, atrapado en una cinta trituradora de la caña, o si un trabajador desaparecía se decía que era obra “del familiar”.

  11. Myofibroblasts in experimental hydronephrosis

    NARCIS (Netherlands)

    Diamond, J R; van Goor, H; Ding, G; Engelmyer, E

    Interstitial fibrosis is a common outcome of longterm ureteral obstruction. One pathological arm of the fibrotic reaction in diverse tissue loci and experimental models is the retraction of granulation tissue. The role of the myofibroblast in granulation tissue contraction and fibrocontractive

  12. Protein S is protective in pulmonary fibrosis.

    Science.gov (United States)

    Urawa, M; Kobayashi, T; D'Alessandro-Gabazza, C N; Fujimoto, H; Toda, M; Roeen, Z; Hinneh, J A; Yasuma, T; Takei, Y; Taguchi, O; Gabazza, E C

    2016-08-01

    Essentials Epithelial cell apoptosis is critical in the pathogenesis of idiopathic pulmonary fibrosis. Protein S, a circulating anticoagulant, inhibited apoptosis of lung epithelial cells. Overexpression of protein S in lung cells reduced bleomycin-induced pulmonary fibrosis. Intranasal therapy with exogenous protein S ameliorated bleomycin-induced pulmonary fibrosis. Background Pulmonary fibrosis is the terminal stage of interstitial lung diseases, some of them being incurable and of unknown etiology. Apoptosis plays a critical role in lung fibrogenesis. Protein S is a plasma anticoagulant with potent antiapoptotic activity. The role of protein S in pulmonary fibrosis is unknown. Objectives To evaluate the clinical relevance of protein S and its protective role in pulmonary fibrosis. Methods and Results The circulating level of protein S was measured in patients with pulmonary fibrosis and controls by the use of enzyme immunoassays. Pulmonary fibrosis was induced with bleomycin in transgenic mice overexpressing human protein S and wild-type mice, and exogenous protein S or vehicle was administered to wild-type mice; fibrosis was then compared in both models. Patients with pulmonary fibrosis had reduced circulating levels of protein S as compared with controls. Inflammatory changes, the levels of profibrotic cytokines, fibrosis score, hydroxyproline content in the lungs and oxygen desaturation were significantly reduced in protein S-transgenic mice as compared with wild-type mice. Wild-type mice treated with exogenous protein S showed significant decreases in the levels of inflammatory and profibrotic markers and fibrosis in the lungs as compared with untreated control mice. After bleomycin infusion, mice overexpressing human protein S showed significantly low caspase-3 activity, enhanced expression of antiapoptotic molecules and enhanced Akt and Axl kinase phosphorylation as compared with wild-type counterparts. Protein S also inhibited apoptosis of alveolar

  13. Shear wave elastography results correlate with liver fibrosis histology and liver function reserve.

    Science.gov (United States)

    Feng, Yan-Hong; Hu, Xiang-Dong; Zhai, Lin; Liu, Ji-Bin; Qiu, Lan-Yan; Zu, Yuan; Liang, Si; Gui, Yu; Qian, Lin-Xue

    2016-05-07

    To evaluate the correlation of shear wave elastography (SWE) results with liver fibrosis histology and quantitative function reserve. Weekly subcutaneous injection of 60% carbon tetrachloride (1.5 mL/kg) was given to 12 canines for 24 wk to induce experimental liver fibrosis, with olive oil given to 2 control canines. At 24 wk, liver condition was evaluated using clinical biochemistry assays, SWE imaging, lidocaine metabolite monoethylglycine-xylidide (MEGX) test, and histologic fibrosis grading. Clinical biochemistry assays were performed at the institutional central laboratory for routine liver function evaluation. Liver stiffness was measured in triplicate from three different intercostal spaces and expressed as mean liver stiffness modulus (LSM). Plasma concentrations of lidocaine and its metabolite MEGX were determined using high-performance liquid chromatography repeated in duplicate. Liver biopsy samples were fixed in 10% formaldehyde, and liver fibrosis was graded using the modified histological activity index Knodell score (F0-F4). Correlations among histologic grading, LSM, and MEGX measures were analyzed with the Pearson linear correlation coefficient. At 24 wk liver fibrosis histologic grading was as follows: F0, n = 2 (control); F1, n = 0; F2, n = 3; F3, n = 7; and F4, n = 2. SWE LSM was positively correlated with histologic grading (r = 0.835, P function reserve in experimental severe fibrosis and cirrhosis.

  14. Las trabajadoras de la salud: vida, trabajo y trastornos mentales

    Directory of Open Access Journals (Sweden)

    Noriega Mariano

    2004-01-01

    Full Text Available Se estudió la relación entre condiciones de vida, trabajo y trastornos mentales en trabajadoras de la salud del Instituto Mexicano del Seguro Social (IMSS. La población se integró por médicas, enfermeras, personal de laboratorio y asistentes médicas (n = 170. La información principal se obtuvo de una encuesta, validada en población trabajadora mexicana. Se encontró que los trastornos mentales están relacionados con todos los ámbitos de la vida de las mujeres. En relación con el ámbito doméstico, se muestra que las mujeres con mayor morbilidad mental son: las que son madres; las que tienen un mayor número de hijos; aquéllas que no cuentan con ayuda para el trabajo doméstico; y las que tienen pareja. En relación con el trabajo asalariado, la morbilidad mental se encontró asociada con la duración de la jornada, el ausentismo y la falta de contenido del trabajo. El desarrollo de habilidades, la satisfacción y la creatividad fueron aspectos "protectores" o preventivos de trastornos mentales y de fatiga. Los principales riesgos y exigencias que actuaron como causantes de estrés fueron: el calor, el ruido, el esfuerzo físico, las posiciones forzadas y el trabajo intenso y repetitivo.

  15. La dimensión ética del trabajo

    Directory of Open Access Journals (Sweden)

    Susana Maidana

    2005-01-01

    Full Text Available El propósito de estas páginas es esclarecer los valores que la filosofía ha asignado al trabajo, presentar sus diferentes sentidos en la sociedad actual y reflexionar sobre el perfil ético de la investigación científica, entendida como una forma de trabajo. El texto se estructura en cinco partes y una conclusión. En la primera se explicita cuál es el significado filosófico de ética, moral y valores; en la segunda parte se explicar el carácter ético del proceso de investigación científica; en la tercera se analiza la concepción del trabajo, según la filosofía; en la cuarta se exponen las nociones positiva y negativa del trabajo en Marx; en la quinta parte se presentan las valoraciones respecto del trabajo en las sociedades contemporáneas y finalmente la conclusión reflexiona sobre la Enfermería, a la luz del marco conceptual previo.

  16. Nephrogenic systemic fibrosis: epidemiology update

    DEFF Research Database (Denmark)

    Marckmann, P.

    2008-01-01

    Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated....... Increasingly poor renal function, aberrations in calcium-phosphate metabolism and erythropoietin treatment seem to increase the risk of the disease and its severity. Up to 25-30% of patients with renal failure exposed to gadolinium-based contrast agents may develop nephrogenic systemic disease. The figure...... that gadolinium-containing contrast agents used for magnetic resonance imaging have an essential causative role in most, if not all, cases of nephrogenic systemic fibrosis. One particular agent, gadodiamide, caused the majority of cases, but gadopentetate dimeglumine has also been implicated in several cases...

  17. Epidemiology of idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Ley B

    2013-11-01

    Full Text Available Brett Ley, Harold R Collard Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, California, USA Abstract: Idiopathic pulmonary fibrosis is a chronic fibrotic lung disease of unknown cause that occurs in adults and has a poor prognosis. Its epidemiology has been difficult to study because of its rarity and evolution in diagnostic and coding practices. Though uncommon, it is likely underappreciated both in terms of its occurrence (ie, incidence, prevalence and public health impact (ie, health care costs and resource utilization. Incidence and mortality appear to be on the rise, and prevalence is expected to increase with the aging population. Potential risk factors include occupational and environmental exposures, tobacco smoking, gastroesophageal reflux, and genetic factors. An accurate understanding of its epidemiology is important, especially as novel therapies are emerging. Keywords: idiopathic pulmonary fibrosis, epidemiology, incidence, prevalence, mortality, risk factors

  18. MRI in mucoviscidosis (cystic fibrosis)

    International Nuclear Information System (INIS)

    Eichinger, M.; Puderbach, M.; Kauczor, H.-U.; Heussel, C.-P.

    2006-01-01

    Cystic fibrosis (CF) is a multi-systemic disease with major impact on the lungs. Pulmonary manifestation is crucial for the prognosis and life expectancy of patients. Imaging modalities and lung function tests reflect the pulmonary status in these patients. The standard imaging modality for diagnosis and follow-up of pulmonary changes is chest x-ray. The gold standard for the detection of parenchymal lung changes remains high resolution computed tomography (HRCT), but this is not used routinely for CF-patients due to radiation exposure. Magnetic resonance imaging (MRI) used to be of no importance in monitoring cystic fibrosis lung disease, as shown in studies from the 1980s and early 1990s. The continuing improvement of MRI techniques, however, has allowed for an adequate application of this non-radiation method in diagnosing the major pulmonary findings in CF, in addition to the assessment of lung function. (orig.) [de

  19. [Historical compilation of cystic fibrosis].

    Science.gov (United States)

    Navarro, Salvador

    2016-01-01

    Cystic fibrosis is the most common life-shortening recessively inherited disorder in the Caucasian population. The genetic mutation that most frequently provokes cystic fibrosis (ΔF508) appeared at least 53,000years ago. For many centuries, the disease was thought to be related to witchcraft and the "evil eye" and it was only in 1938 that Dorothy H. Andersen characterized this disorder and suspected its genetic origin. The present article reviews the pathological discoveries and diagnostic and therapeutic advances made in the last 75 years. The review ends with some considerations for the future. Copyright © 2015 Elsevier España, S.L.U. and AEEH y AEG. All rights reserved.

  20. Fibrosis endomiocárdica

    Directory of Open Access Journals (Sweden)

    María Juliana Rodríguez-González

    2017-07-01

    Una de las formas más comunes de miocardiopatía restrictiva es la fibrosis endomiocárdica la cual es endémica en algunas zonas tropicales especialmente en África (países de bajos ingresos, pero en nuestro medio hay pocos reportes de aparición. Su etiología es desconocida, aunque existen diversos mecanismos que han sido involucrados en su fisiopatología. Su diagnóstico se basa en estudios imagenológicos (ecocardiograma transtorácico y resonancia magnética nuclear cardíaca. El pronóstico es muy pobre, y usualmente se diagnostica en etapas muy avanzadas de la enfermedad. Se describe el caso de una paciente femenina, adulta media, que debutó con cardiopatía restrictiva, cuyo diagnóstico final fue fibrosis endomiocárdica.

  1. Recommendations for quality improvement in genetic testing for cystic fibrosis European Concerted Action on Cystic Fibrosis

    NARCIS (Netherlands)

    Dequeker, E; Cuppens, H; Dodge, J; Estivill, [No Value; Goossens, M; Pignatti, PF; Scheffer, H; Schwartz, M; Schwarz, M; Tummler, B; Cassiman, JJ

    These recommendations for quality improvement of cystic fibrosis genetic diagnostic testing provide general guidelines for the molecular genetic testing of cystic fibrosis in patients/individuals. General strategies for testing as well as guidelines for laboratory procedures, internal and external

  2. La postemancipación y trabajo en Cuba

    Directory of Open Access Journals (Sweden)

    Michael Zeuske

    2015-02-01

    Full Text Available Este artículo analiza los procesos de transculturación y fecundación mutua entre los espacios de trabajo en la postemancipación. El caso de Cuba es complejo, pues se dio en una época de desestructuración progresiva de la esclavitud, jalonada por guerras anticoloniales y una modernización tecnológica ininterrumpida. Se argumenta que aunque las condiciones de trabajo no mejoraron en lo sustancial, sí lo hizo la división sexual del trabajo, los patrones de movilidad, y el acceso a la propiedad informal de la tierra. La modernización de Cuba como productor azucarero introdujo fuerzas de inmenso calado en las luchas sociales del período.

  3. Lactate in cystic fibrosis sputum

    DEFF Research Database (Denmark)

    Bensel, Tobias; Stotz, Martin; Borneff-Lipp, Marianne

    2011-01-01

    Antibiotic therapy is thought to improve lung function in patients with cystic fibrosis (CF) by decreasing neutrophil-derived inflammation. We investigated the origin and clinical significance of lactate in the chronically inflamed CF lung. Methods Lactate was measured in sputa of 18 exacerbated...... and 25 stable CF patients via spectrophotometry and gaschromatography. Lung function was assessed via spirometry. Seven patients with chronic obstructive pulmonary disease (COPD) and three patients with acute lung inflammation served as control groups. Neutrophil and bacterial lactate production...

  4. Anorexia nervosa in cystic fibrosis.

    Science.gov (United States)

    Linkson, Lynette; Macedo, Patricia; Perrin, Felicity M R; Elston, Caroline M

    2018-03-01

    This article explores the challenges associated with diagnosing and managing eating disorders such as anorexia nervosa amongst adolescents and adults with cystic fibrosis. It reviews the known risk factors, generic verses disease specific eating disorder risk screening tools and considers the ethical dilemmas associated with critically low body mass indices. A case review is included to illustrate the complexities of managing both conditions in the context of declining respiratory function. Copyright © 2017. Published by Elsevier Ltd.

  5. Idiopathic pulmonary fibrosis: treatment update.

    LENUS (Irish Health Repository)

    O'Connell, Oisin J

    2011-11-01

    Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. Despite multiple recent clinical trials, there is no strong evidence supporting a survival advantage for any agent in the management of patients with IPF. The limited effectiveness of current treatment regimes has led to a search for novel therapies including antifibrotic strategies. This article reviews the evidence supporting the treatments currently used in the management of IPF.

  6. La crisis financiera global y el Derecho del Trabajo

    Directory of Open Access Journals (Sweden)

    Oscar Ermida Uriarte

    2014-03-01

    Full Text Available Hace tiempo que la frase acuñada por Palomeque, según la cual la crisis económica es "una compañera de viaje histórica del Derecho del trabajo", se convirtió en tópico del Derecho laboral. Mucho antes aún, en 1922, Sinzheimer había señalado que la interferencia Economía-Derecho laboral era inevitable -se podría decir estructural-, por cuanto "corresponde al Derecho del trabajo determinar la forma en que se dispone de los instrumentos y del producto del trabajo". Y siendo el laboral "un Derecho de la distribución" , el cumplimiento de esa función se vuelve más difícil y ríspida en períodos de dificultades económicas, porque si bien no es verdad que inevitablemente la torta deba crecer primero para recién después ser repartida, sí es cierto que la escasez complica y "conflictiviza" la distribución. Por tanto, la emergencia o el simple anuncio de la posibilidad de una crisis económica, produce efectos negativos sobre las relaciones de trabajo.Contenido: Crisis económica y Derecho del trabajo: una relación histórica. La crisis desatada en el ámbito financiero internacional en 2008. Efectos específicos de la crisis sobre el Derecho del trabajo. Algunos ejemplos nacionales concretos. Instrumentos laborales de anticipación o previsión. Conclusiones y sugerencias

  7. Régimen jurídico del trabajo rural

    Directory of Open Access Journals (Sweden)

    Héctor Zapirain

    2014-01-01

    Full Text Available La explotación rural se encuentra sujeta a diversos factores que le otorgan características singulares. Se trata de una actividad asentada preponderantemente en el campo donde el uso de la tierra es esencial. Actividad que, en su ejecución y resultado, depende estrechamente de la naturaleza, de los ciclos biológicos y de las variaciones climáticas. Existe una distancia entre tiempo de trabajo y tiempo de producción. Esta explica, entre otras causas, la tendencia a la precarización de la mano de obra rural. El trabajo regular o permanente, a tiempo completo y remunerado, no es la modalidad predominante, principalmente de países en desarrollo. Esas particularidades han contribuido a la creación de una legislación especial. Una práctica que se observa en la legislación laboral comparada. Orientación que ha influido en el legislador uruguayo.Introducción. Primera parte. Conceptos generales: Trabajo rural (agrario. Peculiaridades especiales de la actividad rural. La reglamentación del trabajo en el agro. Segunda parte. Estatuto del trabajador rural: Breve reseña de la evolución legislativa.  Precisiones pertinentes. Trabajador rural. Tiempo de trabajo y régimen de descansos. Feriados y vacaciones anuales. Salario y beneficios complementarios. Otras prestaciones a cargo del empleador rural. Seguridad y salud en el trabajo. Régimen de despido. Contralor administrativo 

  8. Pathogenic mechanism in lung fibrosis

    International Nuclear Information System (INIS)

    Witschi, H.; Haschek, W.M.; Meyer, K.R.; Ullrich, R.L.; Dalbey, W.E.

    1979-01-01

    The purpose of the study was to examine whether an interaction between two agents causing alveolar epithelial damage would produce lung fibrosis. In mouse lung, intraperitoneal injection of the antioxidant butylated hydroxytoluene causes diffuse alveolar type I cell necrosis, followed by proliferation of type II alveolar cells. In animals exposed to 70% O 2 or 100-200 rad x rays during the phase of type II cell proliferation following BHT, diffuse interstitial lung fibrosis developed within 2 weeks. Quantitative analysis of the lungs for hydroxyproline showed that the interaction between BHT and O 2 or x rays was synergistic. If exposure to O 2 or x rays was delayed until epithelial recovery was complete, no fibrosis was seen. Abnormally high levels of lung collagen persisted up to 6 months after one single treatment with BHT and 100 rad x rays. A commonly seen form of chronic lung damage may thus be caused by an acute interaction between a bloodborne agent which damages the alveolar cell and a toxic inhalant or x rays, provided a critically ordered sequence of exposure is observed

  9. Oral submucous fibrosis: an update

    Directory of Open Access Journals (Sweden)

    Wollina U

    2015-04-01

    Full Text Available Uwe Wollina,1 Shyam B Verma,2 Fareedi Mukram Ali,3 Kishor Patil4 1Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; 2Nirvana Skin Clinic, Vadodara, Gujarat, India; 3Departments of Oral and Maxillofacial Surgery, SMBT Dental College, Sangamner, Maharashtra, India; 4Departments of Oral Pathology and Microbiology, SMBT Dental College, Sangamner, Maharashtra, India Abstract: Oral submucous fibrosis (OSF is a premalignant condition caused by betel chewing. It is very common in Southeast Asia but has started to spread to Europe and North America. OSF can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. OSF is a diagnosis based on clinical symptoms and confirmation by histopathology. Hypovascularity leading to blanching of the oral mucosa, staining of teeth and gingiva, and trismus are major symptoms. Major constituents of betel quid are arecoline from betel nuts and copper, which are responsible for fibroblast dysfunction and fibrosis. A variety of extracellular and intracellular signaling pathways might be involved. Treatment of OSF is difficult, as not many large, randomized controlled trials have been conducted. The principal actions of drug therapy include antifibrotic, anti-inflammatory, and antioxygen radical mechanisms. Potential new drugs are on the horizon. Surgery may be necessary in advanced cases of trismus. Prevention is most important, as no healing can be achieved with available treatments. Keywords: betel nut, betel quid, oral disease, squamous cell carcinoma, tobacco, fibrosis

  10. Cystic Fibrosis-Related Diabetes

    Directory of Open Access Journals (Sweden)

    Kayani Kayani

    2018-02-01

    Full Text Available Cystic fibrosis (CF is the most common autosomal recessive disorder in Caucasian populations. Individuals with CF have seen significant increases in life expectancy in the last 60 years. As a result, previously rare complications are now coming to light. The most common of these is cystic fibrosis-related diabetes (CFRD, which affects 40–50% of CF adults. CFRD significantly impacts the pulmonary function and longevity of CF patients, yet a lack of consensus on the best methods to diagnose and treat CFRD remains. We begin by reviewing our understanding of the pathogenesis of CFRD, as emerging evidence shows the cystic fibrosis transmembrane conductance regulator (CFTR also has important roles in the release of insulin and glucagon and in the protection of β cells from oxidative stress. We then discuss how current recommended methods of CFRD diagnosis are not appropriate, as continuous glucose monitoring becomes more effective, practical, and cost-effective. Finally, we evaluate emerging treatments which have narrowed the mortality gap within the CF patient group. In the future, pharmacological potentiators and correctors directly targeting CFTR show huge promise for both CFRD and the wider CF patient groups.

  11. Efectos de los equipos de trabajo autogestionados (EQTA y del trabajo individual sobre características grupales e individuales

    Directory of Open Access Journals (Sweden)

    AITOR ARITZETA

    2001-01-01

    Full Text Available El presente trabajo observa la medida en la que la estructuración de los trabajadores, de una empresa de automoción, a partir de Equipos de Trabajo Autogestionados EQTA tiene efectos significativos con respecto a las 19 características grupales relacionadas con la efectividad(Campion, Medsker y Higgs, 1993. Partiendo de dos muestras estadísticamente independientes pertenecientes a la misma organización, se observa también, las diferencias que con respecto a la satisfacción laboral, compromiso grupal, autoestima y autonomía personal muestran los sujetos de los EQTA (N=188 y los que realizan su trabajo de forma individual (N= 44. Los resultados indican que los EQTA obtienen valores superiores, con respecto a los que trabajan individualmente, en 13 de las 19 características, estando 18 relacionadas con la satisfacción. Solamente 9 características se relacionaron con la satisfacción en los grupos de trabajo individual. El compromiso grupal, aunque estadísticamente igual en ambos grupos, aparece relacionado con la satisfacción en los EQTA. Los resultados obtenidos demuestran que los EQTA son beneficiosos, no solo económicamente, sino también para el desarrollo de los individuos en la organización. El trabajo tiene implicaciones para el diseño de los grupos autónomos en las organizaciones.

  12. Trabajo remunerado, trabajo doméstico y salud: las diferencias cualitativas y cuantitativas entre mujeres y varones

    Directory of Open Access Journals (Sweden)

    Adriana Cecilia Cruz

    2003-08-01

    Full Text Available En este artículo se plantea la relación entre trabajo remunerado, trabajo doméstico y salud, desde la perspectiva de género. La relación entre ambos tipos de trabajo determina las características y el significado de la vida cotidiana. La metodología utilizada conjuntó técnicas cuantitativas y cualitativas. Se aplicó un cuestionario individual a 256 trabajadores y 121 trabajadoras (n = 377 de una moderna industria farmacéutica en México. También se hicieron siete entrevistas en profundidad entre trabajadores seleccionados por conveniencia. Los hallazgos principales muestran que a pesar de las enormes similitudes encontradas en el trabajo asalariado entre mujeres y varones, las diferencias pueden resumirse en dos conjuntos: por un lado, las distintas formas de segregación de género en el mercado de trabajo y, por el otro, en las formas de enfrentar la vida cotidiana. Se puede decir que los determinantes sociales que han cobijado esta desigual situación son resultado de la complejidad de las relaciones de género y dan lugar a diferentes perfiles patológicos y concepciones sobre la salud.

  13. Mercado de trabajo y estrategias de valorización

    Directory of Open Access Journals (Sweden)

    IGNASI BRUNET ICART

    1998-01-01

    Full Text Available la tesis que se mantiene en este articulo es que un elemento para el analisis sociologico del mercado de trabajo es la subjetividad de los agentes de las relaciones laborales, tanto de los agentes de control -empresariado- como de los agentes controlados -asalariados-. comprender la construccion social de los agentes de las practicas es un requisito imprescindible para analizar las estrategias de los agentes de las relaciones laborales. se trata de evidenciar que las nuevas configuraciones del mundo de la empresa y del trabajo no estan dadas, sino que dependen de la interaccion de los agentes en un campo estrategico.

  14. Trabajo no clásico y flexibilidad

    OpenAIRE

    Toledo,Enrique de la Garza

    2013-01-01

    En este ensayo presentaremos el concepto de trabajo no clásico (De la Garza, 2010), como un intento de dar cuenta no solo de las diferencias en los tipos de trabajo, sino de dimensiones amplias de lo laboral incluidas en forma parcial en otras teorizaciones (Thompson, 1983). Buscaremos precisar el concepto y su alcance, así como las relaciones con las actividades de servicios, que se han vuelto cada vez más importantes en las economías modernas, sin olvidar su peso en las menos desarrolladas....

  15. El trabajo nocturno como factor de riesgo psicosocial

    OpenAIRE

    Mongui Sánchez Hilda Margoth

    1993-01-01

    Las tendencias actuales de la promoción de la seguridad integral, la higiene y el bienestar en el trabajo ya no sólo tienen en cuenta los factores de riesgo tradicionales físicos, químicos, biológicos, ergonómicos y de inseguridad del ambiente laboral, sino otra serie de factores psicosociales inherentes al tipo de empresa, a la organización del trabajo y al clima organizacional que puedan influir sustancialmente en el bienestar físico mental y social del trabajador.

  16. Significados del trabajo desde la profesión docente

    OpenAIRE

    Zapata Calderón, Gustavo Adolfo; Marín López, Alexander

    2013-01-01

    Tesis (Maestría en Gerencia del Talento Humano). Universidad de Manizales. Facultad de Ciencias Sociales y Humanas, 2013 El objetivo principal de esta investigación es describir y comprender la relación de sentidos y categorías que subyacen desde las nuevas condiciones de trabajo y que permiten significar el trabajo como profesión docente. El diseño de la investigación está fundamentado desde el estudio de caso en el cual se demarca un enfoque mixto de investigación, desde lo cualitativo s...

  17. El trabajo colaborativo y la inclusión social

    OpenAIRE

    Amelia Berenice Barragán de Anda; Patricia de Aguinaga Vázquez; Claudia Ávila González

    2010-01-01

    En este artículo se incluyen algunas reflexiones sobre el trabajo colaborativo y el impacto que éste tiene en el proceso de aprendizaje, no sólo en cuanto a la aprehensión de contenidos teórico-académicos, sino también a la adquisición de habilidades digitales, reconocimiento de actitudes, desarrollo de destrezas y aptitudes útiles para ser buen estudiante y para mejorar la práctica profesional a través de la convivencia generada por el trabajo colaborativo. El aprendizaje colaborativo posibi...

  18. El trabajo nocturno como factor de riesgo psicosocial

    Directory of Open Access Journals (Sweden)

    Mongui Sánchez Hilda Margoth

    1993-08-01

    Full Text Available

    Las tendencias actuales de la promoción de la seguridad integral, la higiene y el bienestar en el trabajo ya no sólo tienen en cuenta los factores de riesgo tradicionales físicos, químicos, biológicos, ergonómicos y de inseguridad del ambiente laboral, sino otra serie de factores psicosociales inherentes al tipo de empresa, a la organización del trabajo y al clima organizacional que puedan influir sustancialmente en el bienestar físico mental y social del trabajador.

  19. La personalidad y los equipos de trabajo efectivos

    OpenAIRE

    Alcázar Pretelt, Erika

    2015-01-01

    Cuando un grupo de gente trabaja en pos de una meta en común, puede hablarse de trabajo en equipo. Sin embargo, hoy en día el problema se centra en cómo conseguir que el trabajo en equipo sea eficaz. Trabajar en equipo consiste en colaborar organizadamente para alcanzar un objetivo en común, entendiendo las interdependencias que se dan entre los miembros del equipo y sacar el máximo provecho de ellas para alcanzar el objetivo.

  20. Hyperplasia of elastic tissue in hepatic schistosomal fibrosis

    Directory of Open Access Journals (Sweden)

    Zilton A. Andrade

    1991-12-01

    Full Text Available Elastic tissue hyperplasia, revealed by means of histological, immunocytochemical and ultrastructural methods, appeared as a prominent change in surgical liver biopsies taken from 61 patients with schistosomal periportal and septal fibrosis. Such hyperplasia was absent in ecperimental murine schistosomiasis, including mice with "pipe-stem" fibrosis. Displaced connective tissue cells in periportal areas, such as smooth muscle cells, more frequently observed in human material, could be the site of excessive elastin synthesis, and could explain the differences observed in human and experimental materials. Elastic tissue, sometimes represented by its microfibrillar components, also appeared to be more condensed in areas of matrix (collagen degradation, suggesting a participation of this tissue in the remodelling of the extracellular matrix. By its rectratile properties elastic tissue hyperplasia in hepatic schistosomiasis can cause vascular narrowing and thus play a role in the pathogenesis of portal hypeertension.

  1. Otorhinolaryngologic manifestations of cystic fibrosis: literature review

    Directory of Open Access Journals (Sweden)

    Carvalho, Carolina Pimenta

    2008-12-01

    Full Text Available Introduction: Cystic Fibrosis is the most common recessive autosomic genetic disease among Caucasians. It's caused by mutations in the gene that decodes regulatory protein for transmembrane conductance, resulting in defective transport of chlorine. Objective: Review the literature about Cystic Fibrosis, with emphasis on otorhinolaryngologic manifestations. Method: The online Pub Med databases were researched and we applied the following search terms Fibrosis Cystic and Sinusitis, and Mucoviscidosis and Sinusitis. Conclusions: Although it is not the main cause of death, the otorhinolaryngologic manifestations of the Cystic Fibrosis bring important morbidity to these patients.

  2. Fibrosis pulmonar asociada a vasculitis con anticuerpos anticitoplasmáticos positivos

    OpenAIRE

    Marcelo Fernández Casares; Alejandra González; Flavia Caputo; Yanina Bottinelli; Patricia Nastavi; Marcelo Zamboni

    2012-01-01

    Las complicaciones pulmonares más conocidas de las vasculitis con anticuerpos anticitoplasmáticos de los neutrófilos (ANCA) positivos (VAA), son la hemorragia alveolar, los granulomas y la estenosis de la vía aérea. En los últimos años han aparecido algunos informes aislados que muestran la asociación con fibrosis pulmonar (FP), sugiriendo que ésta sería otra complicación de las VAA. En este trabajo informamos dos casos con dicha asociación describiendo sus características clínicas, tomográfi...

  3. Empresas de trabajo temporal y mercado de trabajo: el impacto de la crisis económica y laboral

    OpenAIRE

    Hidalga Gutiérrez, Roberto

    2016-01-01

    El presente trabajo tiene como objetivo analizar el papel de las ETTs en el mercado de trabajo español y estudiar la evolución de su penetración en el mismo, prestando especial atención al efecto de la crisis económica Departamento de Fundamentos del Análisis Económico e Historia e Instituciones Económicas Grado en Administración y Dirección de Empresas

  4. Efectos de los equipos de trabajo autogestionados (EQTA) y del trabajo individual sobre características grupales e individuales

    OpenAIRE

    AITOR ARITZETA

    2001-01-01

    El presente trabajo observa la medida en la que la estructuración de los trabajadores, de una empresa de automoción, a partir de Equipos de Trabajo Autogestionados EQTA tiene efectos significativos con respecto a las 19 características grupales relacionadas con la efectividad(Campion, Medsker y Higgs, 1993). Partiendo de dos muestras estadísticamente independientes pertenecientes a la misma organización, se observa también, las diferencias que con respecto a la satisfacción laboral, compromi...

  5. Drogodependencias en el lugar de trabajo: Pautas generales de intervención desde la medicina del trabajo

    Directory of Open Access Journals (Sweden)

    Carmen Otero Dorrego

    Full Text Available El abuso de drogas es un importante problema de salud pública, así como un grave problema laboral en los países industrializados. Las serias consecuencias laborales (menor rendimiento, aumento del número de accidentes, etc y la posibillidad de abordar el problema con éxito desde los servicios de salud laboral de las empresas, hacen necesarias la creación de políticas y programas de intervención. El objetivo general de todos estos programas es conseguir la rehabilitación personal y laboral de los trabajadores afectados. Otros objetivos secundarios son mejorar los índices de absentismo y accidentabilidad, esta blecer pautas generales de actuación de los médicos del trabajo para intervenir en las situaciones de abuso de drogas en el lugar de trabajo, así como favorecer la reincorporación laboral adecuada de los trabajadores que han seguido un programa de deshabituación. En este artículo se hace una revisión de datos epidemiológicos, consecuencias laborales, personales y sociales, diferentes normas y recomendaciones internacionales y nacionales, así como de programas específicos de empresas nacionales y extranjeras en los diferentes sectores de producción. Por último, se describen las pautas generales de actuación de los médicos del trabajo de los servicios de salud laboral. Las actuaciones del Médico del trabajo en el ámbito de la Prevención Primaria se dirigirán a la detección de factores de riesgo en el puesto de trabajo (evaluación de riesgos psicosociales y facilidad de acceso a drogas en el trabajo, entre otros y factores individuales (detección precoz de trabajadores especialmente sensibles, aplicando medidas correctoras (formativas e informativas, adaptación de puestos de trabajo, etc.. El médico del trabajo también se ocupará de realizar un diagnóstico precoz (Prevención Secundaria para tratamiento de desintoxicación y deshabituación a través de la red asistencial del Sistema Nacional de Salud. Y, por

  6. La trata de personas en la modalidad de trabajo infantil

    Directory of Open Access Journals (Sweden)

    Angélica García Marbella

    2017-01-01

    Full Text Available En este trabajo se describen las causas y el proceso evolutivo del trabajo infantil en México; sin embargo, en la exposición se retoman elementos que identifican el problema en el contexto mundial. En ese sentido, se destaca que durante algún tiempo el quehacer de los infantes en el mercado de trabajo era considerado como un medio para que aprendieran determinado oficio, así como que dicha connotación no ha dejado de existir, pero ahora coexiste con otras tendencias asociadas a la delincuencia organizada, tales como prostitución, pornografía y turismo infantil; es decir, con actividades vinculadas estrechamente con la trata de personas. La pretensión es evidenciar el problema y las principales prácticas de quienes llevan a cabo dicho comportamiento; por lo que hubo necesidad de recurrir a la aplicación de una entrevista focalizada, basada en ocho informantes, con la finalidad de conocer la percepción de personas involucradas en dicha problemática. Al final del trabajo, lo observado es que la problemática en cuestión sigue creciendo en México; situación que es corroborada por los datos que aportan diversas instituciones, que señalan que en la actualidad este país ocupa el primer lugar en dicho comportamiento.

  7. Historia del trabajo social latinoamericano. Estado del arte

    OpenAIRE

    Gloria E. Leal L.; Édgar Malagón B.

    2006-01-01

    La literatura sobre la historia del trabajo social latinoamericano contiene vacíos importantes y planteamientos de lo que significó el desarrollo de la profesionalización en los años setenta y en el período de la reconceptualización. Por tal razón es indi

  8. Historia del trabajo social latinoamericano. Estado del arte

    Directory of Open Access Journals (Sweden)

    Gloria E. Leal L.

    2006-01-01

    Full Text Available La literatura sobre la historia del trabajo social latinoamericano contiene vacíos importantes y planteamientos de lo que significó el desarrollo de la profesionalización en los años setenta y en el período de la reconceptualización. Por tal razón es indi

  9. 90.000 trabajos disponibles en Digital.CSIC

    OpenAIRE

    Oficina Técnica de Digital.CSIC; Román-Molina, Juan

    2014-01-01

    Póster elaborado al alcanzar el repositorio los 90.000 trabajos.-- Se incluye versión en formato PDF.-- El resto de los hitos está disponible en la siguiente url: http://digital.csic.es/enCifras/crecimientoLineal.jsp

  10. The Sociology and Entrenchment. A Cystic Fibrosis Test for Everyone?

    DEFF Research Database (Denmark)

    Koch, Lene; Stemerding, Dirk

    1994-01-01

    Socialmedicine, genetic screening, cystic fibrosis, ethics, political regulation, sociology of technology......Socialmedicine, genetic screening, cystic fibrosis, ethics, political regulation, sociology of technology...

  11. Condiciones de trabajo y salud de mototaxistas Cartagena - Colombia

    Directory of Open Access Journals (Sweden)

    Irma Yolanda Castillo Avila

    2013-01-01

    Full Text Available Objetivo: Determinar las condiciones de trabajo y salud de los moto-taxistas de la ciudad de Cartagena. Metodología: Se realizó un estudio descriptivo, con una muestra de 423 moto-taxistas de la ciudad, elegidos por muestreo aleatorio por conglomerados. Para la recolección de información fue utilizada una encuesta socio-demográfica y una adaptación de la VI En- cuesta Nacional de Condiciones de Trabajo del Instituto Nacional de Seguridad e Higiene en el Trabajo de España. Se aplicó estadística descriptiva a los datos utilizando el programa estadístico SPSSS versión 17. Resultados: Participaron en el estudio 423 moto-taxistas, 97.9% (414 son hombres. El 46.3 % (196 son bachilleres y el 2.1% (9 han finalizado estudios universitarios. En cuanto a las condiciones de trabajo y salud, el 54.8% (232 manifestaron ser trabajadores independientes propietarios de las motos. El 18.2% (77 aseguro estar expuesto a ruido elevado, 40.7% (173 debe trabajar con lluvia, 91% (385 respira polvos y humos durante la realización de su trabajo. La mediana de horas diarias laboradas es 10. El 53.7% (227 aseguraron no tener ningún tipo de afiliación a seguridad social; El 74.7% (316 consideran que su trabajo afecta su salud, siendo las afecciones más frecuentes: dolor de espalda 65.2% (276, dolor de cuello 34% (144 y enfermedades de la piel 25.5% (108. Conclusión: El moto-taxismo, es el tipo de trabajo informal más común en la ciudad de Cartagena. Los trabajadores no cuentan con afiliación al sistema general de seguridad social en salud, y trabajan en condiciones que ponen en riesgo su salud.

  12. Comparative study of two models of combined pulmonary fibrosis and emphysema in mice.

    Science.gov (United States)

    Zhang, Wan-Guang; Wu, Si-Si; He, Li; Yang, Qun; Feng, Yi-Kuan; Chen, Yue-Tao; Zhen, Guo-Hua; Xu, Yong-Jian; Zhang, Zhen-Xiang; Zhao, Jian-Ping; Zhang, Hui-Lan

    2017-04-01

    Combined pulmonary fibrosis and emphysema (CPFE) is an "umbrella term" encompassing emphysema and pulmonary fibrosis, but its pathogenesis is not known. We established two models of CPFE in mice using tracheal instillation with bleomycin (BLM) or murine gammaherpesvirus 68 (MHV-68). Experimental mice were divided randomly into four groups: A (normal control, n=6), B (emphysema, n=6), C (emphysema+MHV-68, n=24), D (emphysema+BLM, n=6). Group C was subdivided into four groups: C1 (sacrificed on day 367, 7 days after tracheal instillation of MHV-68); C2 (day 374; 14days); C3 (day 381; 21days); C4 (day 388; 28days). Conspicuous emphysema and interstitial fibrosis were observed in BLM and MHV-68 CPFE mouse models. However, BLM induced diffuse pulmonary interstitial fibrosis with severely diffuse pulmonary inflammation; MHV-68 induced relatively modest inflammation and fibrosis, and the inflammation and fibrosis were not diffuse, but instead around bronchioles. Inflammation and fibrosis were detectable in the day-7 subgroup and reached a peak in the day-28 subgroup in the emphysema + MHV-68 group. Levels of macrophage chemoattractant protein-1, macrophage inflammatory protein-1α, interleukin-13, and transforming growth factor-β1 in bronchoalveolar lavage fluid were increased significantly in both models. Percentage of apoptotic type-2 lung epithelial cells was significantly higher; however, all four types of cytokine and number of macrophages were significantly lower in the emphysema+MHV-68 group compared with the emphysema +BLM group. The different changes in pathology between BLM and MHV-68 mice models demonstrated different pathology subtypes of CPFE: macrophage infiltration and apoptosis of type-II lung epithelial cells increased with increasing pathology score for pulmonary fibrosis. Copyright © 2017 Elsevier GmbH. All rights reserved.

  13. Trabajo y salud en la mujer: análisis comparativo de mujeres con trabajo remunerado y amas de casa

    Directory of Open Access Journals (Sweden)

    Mª E. ESCALERA IZQUIERDO

    2000-01-01

    Full Text Available El objetivo de este estudio es detectar y analizar las posibles diferencias en salud, tanto psicológica como física, en mujeres con roles múltiples y amas de casa en exclusiva. Todas ellas tenían hijas/os, pareja y bastantes, un trabajo remunerado. Además de las diferencias, se han estudiado otras variables con las que la salud pudiera estar relacionada como las condiciones de trabajo (tanto en el campo laboral como en el doméstico, familiares (afectivas y ayuda instrumental, la tensión entre roles y recursos (autoestima, conductas de salud y de riesgo, apoyo social, nivel educativo e ingresos. Los resultados mostraron que existía una gran diferencia en las variables que explicaban la salud de las mujeres según trabajasen o no fuera de casa y una tendencia hacia una mejor salud por parte de las mujeres con trabajo remunerado. Para ambos grupos las variables más relevantes para una mejor salud estuvieron relacionadas con las conductas de salud y de riesgo y la tensión entre roles. En las que trabajaban fuera de casa fueron muy significativas la autoestima y las variables relativas a sus roles familiares (relaciones con la pareja e hijos/as así como las condiciones del trabajo doméstico, por delante de las laborales.

  14. Idiopathic pulmonary fibrosis: evolving concepts.

    Science.gov (United States)

    Ryu, Jay H; Moua, Teng; Daniels, Craig E; Hartman, Thomas E; Yi, Eunhee S; Utz, James P; Limper, Andrew H

    2014-08-01

    Idiopathic pulmonary fibrosis (IPF) occurs predominantly in middle-aged and older adults and accounts for 20% to 30% of interstitial lung diseases. It is usually progressive, resulting in respiratory failure and death. Diagnostic criteria for IPF have evolved over the years, and IPF is currently defined as a disease characterized by the histopathologic pattern of usual interstitial pneumonia occurring in the absence of an identifiable cause of lung injury. Understanding of the pathogenesis of IPF has shifted away from chronic inflammation and toward dysregulated fibroproliferative repair in response to alveolar epithelial injury. Idiopathic pulmonary fibrosis is likely a heterogeneous disorder caused by various interactions between genetic components and environmental exposures. High-resolution computed tomography can be diagnostic in the presence of typical findings such as bilateral reticular opacities associated with traction bronchiectasis/bronchiolectasis in a predominantly basal and subpleural distribution, along with subpleural honeycombing. In other circumstances, a surgical lung biopsy may be needed. The clinical course of IPF can be unpredictable and may be punctuated by acute deteriorations (acute exacerbation). Although progress continues in unraveling the mechanisms of IPF, effective therapy has remained elusive. Thus, clinicians and patients need to reach informed decisions regarding management options including lung transplant. The findings in this review were based on a literature search of PubMed using the search terms idiopathic pulmonary fibrosis and usual interstitial pneumonia, limited to human studies in the English language published from January 1, 2000, through December 31, 2013, and supplemented by key references published before the year 2000. Copyright © 2014 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

  15. Outcome in cystic fibrosis liver disease.

    LENUS (Irish Health Repository)

    Rowland, Marion

    2011-01-01

    Evidence suggests that cystic fibrosis liver disease (CFLD) does not affect mortality or morbidity in patients with cystic fibrosis (CF). The importance of gender and age in outcome in CF makes selection of an appropriate comparison group central to the interpretation of any differences in mortality and morbidity in patients with CFLD.

  16. Laparoscopic cholecystectomy in adult cystic fibrosis.

    LENUS (Irish Health Repository)

    McGrath, D S

    2012-02-03

    Two female patients with Cystic Fibrosis, attending the Adult Regional Cystic Fibrosis centre at the Cork University Hospital, were investigated for upper abdominal pain and found to have gallstones at ultrasonography. Laparoscopic cholecystectomy was performed successfully and, without complication, in both patients.

  17. Genetics Home Reference: idiopathic pulmonary fibrosis

    Science.gov (United States)

    ... these health problems has idiopathic pulmonary fibrosis . Other respiratory diseases, some of which are less serious, can cause similar signs and symptoms. In people with idiopathic pulmonary fibrosis , scarring of the lungs increases over time until the lungs can no longer ...

  18. Imaging pulmonary fibrosis; Imagerie des fibroses pulmonaires

    Energy Technology Data Exchange (ETDEWEB)

    Brauner, M.W.; Rety, F.; Naccache, J.M.; Girard, F.; Valeyre, D.F. [Hopital Avicenne, 93 - Bobigny (France). Service de radiologie et de pneumologie

    2001-02-01

    Localized fibrosis of the lung is usually scar tissue while diffuse pulmonary fibrosis is more often a sign of active disease. Chronic infiltrative lung disease may be classified into four categories: idiopathic pneumonitis, collagen diseases, granulomatosis (sarcoidosis), and caused by known diseases (pneumoconiosis, hypersensitivity pneumonitis, drug-induced lung disease, radiation). (authors)

  19. Self-management education for cystic fibrosis.

    LENUS (Irish Health Repository)

    Savage, Eileen

    2011-01-01

    Self-management education may help patients with cystic fibrosis and their families to choose, monitor and adjust treatment requirements for their illness, and also to manage the effects of illness on their lives. Although self-management education interventions have been developed for cystic fibrosis, no previous systematic review of the evidence of effectiveness of these interventions has been conducted.

  20. Unusual Presentation Of Idiopathic Retroperitoneal Fibrosis: Case ...

    African Journals Online (AJOL)

    Idiopathic retroperitoneal fibrosis (IRF) is an uncommon entity described as progressive proliferation of connective tissues leading to a fibrous plaque-like lesions that encases the aorta and inferior vena cava inferior to the level of the renal arteries. Mass forming retroperitoneal fibrosis is rare. We present a rare case of a ...

  1. Retorno al trabajo tras cáncer de mama

    Directory of Open Access Journals (Sweden)

    Araceli López-Guillén García

    Full Text Available Resumen El cáncer de mama frecuentemente es causa de largos procesos de baja. La duración media de las bajas por cáncer de mama es de unos 320 días, estando entre los tres procesos principales que causan bajas de más de 365 días junto con la lumbalgia y el trastorno ansioso depresivo. Cada año se producen 26.000 casos nuevos en España de los que en su mayoría se producen en plena edad laboral. La supervivencia a los cinco años entre mujeres de 30 a 60 años es del 86%. El cáncer de mama es la segunda causa de inicio de expedientes de incapacidad permanente a los doce meses, tras la lumbalgia. Sólo el 53% retomará el trabajo. El retorno al trabajo se vuelve dificultoso tanto por la intensidad y pauta espaciada de los tratamientos, como por la afectación de la calidad de vida, como por la ausencia prolongada del trabajo. Influyendo factores personales de la trabajadora, unos por ella misma, otros ligados al cáncer y su evolución, y factores laborales ligados al tipo de trabajo, riesgos, condiciones y exigencias del mismo y otros factores del mercado de trabajo; que todos ellos considerados no siempre hacen que la vuelta al trabajo sea posible. Material y método: Se han revisado hasta octubre de 2016 las siguientes bases de datos bibliográficas: SciELO, y PUBMED. Así como la Bibliografía y documentos de consulta citados en la misma. Conclusiones: Es preciso facilitar el retorno al trabajo, en especial de aquellos casos más complicados que han precisado de largas bajas pero aun así ya están curados o con una mejoría que permite trabajar. Ante el fenómeno del cáncer de mama y su impacte incapacitante, es preciso conocer el mismo con certeza por lo que se hace necesario la realización urgente del Mapa de Incapacidad en España. Para evitar controversias entre el alta médica para trabajar y la no aptitud para el trabajo debe de institucionalizarse el uso de la Ficha de Valoración Ocupacional. Ante la toma de decisiones es

  2. Pulmonary complications of cystic fibrosis

    International Nuclear Information System (INIS)

    Ng, M.Y.; Flight, W.; Smith, E.

    2014-01-01

    The life expectancy of patients with cystic fibrosis (CF) has steadily increased over recent decades with a corresponding increase in the frequency of complications of the disease. Radiologists are increasingly involved with managing and identifying the pulmonary complications of CF. This article reviews the common manifestations of CF lung disease as well as updating radiologists with a number of less well-known complications of the condition. Early and accurate detection of the pulmonary effects of CF are increasingly important to prevent irreversible lung damage and give patients the greatest possibility of benefiting from the new therapies becoming available, which correct the underlying defect causing CF

  3. Liver manifestations of cystic fibrosis

    International Nuclear Information System (INIS)

    Akata, Deniz; Akhan, Okan

    2007-01-01

    Chronic liver disease is one of the major complications of cystic fibrosis (CF). Significant liver disease is seen in 13-25% of children with CF. Improved life expectancy and prolonged follow-up have favored better characterization of the hepatic manifestations of CF and allowed direct observation of an increasing number of liver-related events. Liver disease typically develops in the first decade of life, with the incidence dropping rapidly after the age of 10 years. The wide spectrum of liver disease ranging from asymptomatic gallbladder abnormalities to biliary cirrhosis will be reviewed in this article

  4. Endocrine Disorders in Cystic Fibrosis.

    Science.gov (United States)

    Blackman, Scott M; Tangpricha, Vin

    2016-08-01

    Cystic fibrosis is frequently complicated by endocrine disorders. Diabetes can be expected to affect most with CF and pancreatic insufficiency and varies widely in age of onset, but early identification and treatment improve morbidity and mortality. Short stature can be exacerbated by relative delay of puberty and by use of inhaled corticosteroids. Bone disease in CF causes fragility fractures and should be assessed by monitoring bone mineral density and optimizing vitamin D status. Detecting and managing endocrine complications in CF can reduce morbidity and mortality in CF. These complications can be expected to become more common as the CF population ages. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. Estrategia Iberoamericana de Seguridad y Salud en el Trabajo: políticas públicas para un trabajo decente

    Directory of Open Access Journals (Sweden)

    Olga Beatriz Guzmán Suárez

    Full Text Available Resumen A través del presente artículo, se pretende realizar una revisión del marco institucional global y regional en materia de seguridad y salud en el trabajo con un enfoque de derechos humanos, cuyo eje central serán las estrategias adoptadas para la generación de políticas públicas, enfocadas en la prevención y protección de los trabajadores contra los riesgos laborales. El desarrollo e implementación de políticas públicas en materia de seguridad y salud en el trabajo, se constituye como uno de los retos que debe ser asumido con la participación de diferentes agentes sociales, en el marco del diálogo social y del enfoque de derechos. Para ello, surge la Estrategia Iberoamericana de Seguridad y Salud en el Trabajo (EISST, concebida como un instrumento recomendado a los gobiernos, organizaciones empresariales y sindicales, entidades aseguradoras, colectivos profesionales, sector educativo y la sociedad entre otros, para que se comprometan y adhieran a los objetivos establecidos en el documento y de esta manera establecer de forma consensuada, el marco general que rija la seguridad y salud en el escenario laboral actual de la región. A partir de una revisión sistemática de la literatura, se realiza la contextualización sobre políticas públicas en salud laboral. Se destaca la importancia de las estrategias en seguridad y salud en el trabajo, y la necesidad de desarrollar e implementar políticas públicas con enfoque de derechos humanos, así como políticas que estimulen el diálogo entre los agentes sociales, que promuevan el logro de un trabajo decente.

  6. Turnos de trabajo: ¿un factor de riesgo cardiovascular?

    Directory of Open Access Journals (Sweden)

    José Santana-Herrera

    Full Text Available Objetivos: Describir según la literatura existente si hay evidencia científica de que los turnos de trabajo son un factor de riesgo cardiovascular e identificar las intervenciones en los tipos de turno más efectivas para reducir dichos riesgos. Material y métodos: Se realizó una búsqueda bibliográfica en 10 bases de datos obteniéndose 13 artículos. El diseño de estos estudios fueron: 7 de intervención, 1 de cohortes, 1 casos control, 3 descriptivos transversales y un estudio piloto. Se agruparon los trabajos según la dirección y velocidad de rotación, ergonomía de los turnos y cambios en el número de turnos analizándose la modificación de los biomarcadores según el tipo de intervención. Resultados: La muestra total fue de 12.332 trabajadores. El cambio en la dirección de rotación del turno de trabajo de atrás hacia adelante mostró cambios favorables como disminución del nivel de glucosa, TG, Ác. Úrico y TAS. Rotaciones rápidas en sentido horario pueden ser beneficiosas observándose una disminución del colesterol total, relación colesterol total/LDL y un aumento de HDL. Al asociar la dirección y velocidad de rotación no se obtuvieron modificaciones significativas de los biomarcadores. El cambio ergonómico en los turnos disminuyo las alteraciones lipídicas, TA y FC. Finalmente la diabetes mellitus se vio influenciada negativamente cuando cambiamos de tres turnos a dos turnos de trabajo. Conclusiones: Los artículos publicados sugieren un impacto negativo del trabajo por turnos en el riesgo cardiovascular que puede modificarse favorablemente con cambios en la organización del trabajo (sistema de rotación rápido en sentido horario, turnos flexibles y rotaciones de tres turnos.

  7. Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.

    Science.gov (United States)

    van Koppen, Arianne; Verschuren, Lars; van den Hoek, Anita M; Verheij, Joanne; Morrison, Martine C; Li, Kelvin; Nagabukuro, Hiroshi; Costessi, Adalberto; Caspers, Martien P M; van den Broek, Tim J; Sagartz, John; Kluft, Cornelis; Beysen, Carine; Emson, Claire; van Gool, Alain J; Goldschmeding, Roel; Stoop, Reinout; Bobeldijk-Pastorova, Ivana; Turner, Scott M; Hanauer, Guido; Hanemaaijer, Roeland

    2018-01-01

    The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynamics of key molecular processes involved in NASH and to rank early markers for hepatic fibrosis. A time-course study in low-density lipoprotein-receptor knockout. Leiden mice on a high-fat diet was performed to identify the temporal dynamics of key processes contributing to NASH and fibrosis. An integrative systems biology approach was used to elucidate candidate markers linked to the active fibrosis process by combining transcriptomics, dynamic proteomics, and histopathology. The translational value of these findings were confirmed using human NASH data sets. High-fat-diet feeding resulted in obesity, hyperlipidemia, insulin resistance, and NASH with fibrosis in a time-dependent manner. Temporal dynamics of key molecular processes involved in the development of NASH were identified, including lipid metabolism, inflammation, oxidative stress, and fibrosis. A data-integrative approach enabled identification of the active fibrotic process preceding histopathologic detection using a novel molecular fibrosis signature. Human studies were used to identify overlap of genes and processes and to perform a network biology-based prioritization to rank top candidate markers representing the early manifestation of fibrosis. An early predictive molecular signature was identified that marked the active profibrotic process before histopathologic fibrosis becomes manifest. Early detection of the onset of NASH and fibrosis enables identification of novel blood-based biomarkers to stratify patients at risk, development of new therapeutics, and help shorten (pre)clinical experimental time frames.

  8. Tumoral fibrosis effect on the radiation absorbed dose of 177Lu–Tyr3-octreotate and 177Lu–Tyr3-octreotate conjugated to gold nanoparticles

    International Nuclear Information System (INIS)

    Azorín-Vega, E.P.; Zambrano-Ramírez, O.D.; Rojas-Calderón, E.L.; Ocampo-García, B.E.; Ferro-Flores, G.

    2015-01-01

    The aim of this work was to evaluate the tumoral fibrosis effect on the radiation absorbed dose of the radiopharmaceuticals 177 Lu–Tyr 3 -octreotate (monomeric) and 177 Lu–Tyr 3 -octreotate–gold nanoparticles (multimeric) using an experimental HeLa cells tumoral model and the Monte Carlo PENELOPE code. Experimental and computer micro-environment models with or without fibrosis were constructed. Results showed that fibrosis increases up to 33% the tumor radiation absorbed dose, although the major effect on the dose was produced by the type of radiopharmaceutical (112 Gy-multimeric vs. 43 Gy-monomeric). - Highlights: • Fibrosis increases the radiation absorbed dose to the tumor. • Fibrosis increases the radiopharmaceutical residence time in the tumor. • The multimeric nature of the radiopharmaceuticals enhances the radiopharmaceutical retention

  9. Postinjection Muscle Fibrosis from Lupron

    Directory of Open Access Journals (Sweden)

    Erica Everest

    2015-01-01

    Full Text Available We describe the case of a 6.5-year-old girl with central precocious puberty (CPP, which signifies the onset of secondary sexual characteristics before the age of eight in females and the age of nine in males as a result of stimulation of the hypothalamic-pituitary-gonadal axis. Her case is likely related to her adoption, as children who are adopted internationally have much higher rates of CPP. She had left breast development at Tanner Stage 2, adult body odor, and mildly advanced bone age. In order to halt puberty and maximize adult height, she was prescribed a gonadotropin releasing hormone analog, the first line treatment for CPP. She was administered Lupron (leuprolide acetate Depot-Ped (3 months intramuscularly. After her second injection, she developed swelling and muscle pain at the injection site on her right thigh. She also reported an impaired ability to walk. She was diagnosed with muscle fibrosis. This is the first reported case of muscle fibrosis resulting from Lupron injection.

  10. Drug-induced Pulmonary Fibrosis

    International Nuclear Information System (INIS)

    Daba, Mohammad H.; Al-Arifi, Mohammad N; Gubar, Othman A.; El-Tahir, Kamal E.

    2004-01-01

    Pulmonary fibrosis is characterized by the accumulation of excessive connective tissue in the lungs. Its causes include chronic administration of some drugs for example bleomycin, cyclophosphamide, amiodarone, procainamide, penicillamine, gold and nitrofurantoin; exposure to certain environmental factors such as gases, asbestos and silica and bacterial or fungal infections. Some systemic diseases also predispose to the disease for example rheumatoid arthritis and systemic lupus erythematosus. The disease is associated with release of oxygen radicals and some mediators such as tumor necrosis factor-alpha TNF-alpha, transforming growth factor-beta Tbgf-beta, PDGF, If-I, Et-I and interleukins 1, 4, 8 and 13. The symptoms of the disease include dyspne a, non-productive cough, fever and damage to the lung cells. It is diagnosed with the aid of chest radiography, high resolution computed tomographic scanning and the result of pulmonary function tests. Drug-induced pulmonary fibrosis may involve release of free oxygen radicals and various cytokines for example Il-I beta and TNF-alpha via activation of nuclear transcription factor Nf-beta as in the case of bleomycin and mitomycin or via release of TGF-beta as in case of tamoxifen or via inhibition of macrophages and lymphocytes phospholipases as in the case of amiodarone with the resultant accumulation of phospholipids and reduction of the immune system. (author)

  11. Violencia en el trabajo: investigaciones realizadas en Colombia

    Directory of Open Access Journals (Sweden)

    José Gabriel Carvajal Orozco

    2013-12-01

    Full Text Available El propósito de esta ponencia es mostrar los resultados de una exploración bibliográfica concerniente a las investigaciones llevadas a cabo en los últimos diez años, sobre el tema de la violencia en el lugar de trabajo. Se consultaron 16 artículos –5 empíricos, 11 teóricos–, publicados en revistas científicas colombianas, en universidades públicas y privadas, en instituciones gubernamentales y en bases de datos académicas. La ponencia está estructurada en tres partes: la primera presenta los aspectos metodológicos; la segunda expone los resultados de la exploración, donde se muestran las problemáticas que se han abordado en las investigaciones sobre violencia en el trabajo, y la tercera y última parte contiene las conclusiones acerca de los resultados obtenidos.

  12. Medicina legal: concepto pericial en un accidente de trabajo

    Directory of Open Access Journals (Sweden)

    G. Uribe Cualla

    1935-03-01

    Full Text Available En la comunicación número 2249 de fecha 24 de noviembre de 1935, de la Oficina General del Trabajo, se dice lo siguiente: "Con carácter devolutivo y constante de 20 fojas útiles, me permito enviar a Ud. el expediente relacionado con la reclamación del señor S. G., por un accidente de trabajo, con el objeto de que esa ilustrada Oficina se sirva emitir su concepto sobre el caso del señor G. El Ministerio de Guerra niega la indemnización porque según dictamen de los Oficiales de Sanidad del Ejército, la lesión de G. no ha dejado incapacidad permanente, sino que es una incapacidad simulada.

  13. Culturas juveniles y trabajo social con jóvenes

    Directory of Open Access Journals (Sweden)

    GLADYS CASTIBLANCO-LEMUS

    2008-01-01

    Full Text Available Este trabajo tiene como propósito señalar algunas implicaciones teóricas y practicas de la relación entre la categoría culturas juveniles, concretamente desde los resultados del proyecto de investigación: Identidades juveniles: Música y producción cultural. Etnografía de agrupaciones Rave y hip hop rap en Bogotá y un conjunto de premisas conceptuales del trabajo social con jóvenes. Para tal efecto se abordarán tres aspectos: en primer lugar, se presenta una síntesis del proyecto destacando los más importantes resultados; en segundo lugar se plantean los referentes conceptuales que permiten establecer la relación y finalmente se señalan algunas pistas para incorporar otros contenidos para la actuación profesional con jóvenes.

  14. Observaciones sobre accidentes de trabajo y enfermedades profesionales

    Directory of Open Access Journals (Sweden)

    Guillermo Sarmiento López

    1948-03-01

    Full Text Available En los tiempos antiguos no existía ley ni disposición alguna de carácter social que favoreciera a los trabajadores incapacitados por enfermedad o por accidente, por tanto, eran tratados como esclavos o considerados como animales. Los accidentes de trabajo y las enfermedades profesionales eran casi desconocidas antes de la introducción de la maquinaria en la industria, por lo cual no existía el derecho a indemnización por concepto de daños que sufriera el trabajador en el desempeño de sus labores. Solamente se conocen los edictos de Rotari (año 645 de la éra cristiana lanzados en Italia con el fin de reparar los accidentes de los obreros de la construcción y después, en la época del Renacimiento, algunas publicaciones que hablan de ciertas enfermedades de los trabajadores (Ellemborg 1473, Paracelso 1493-1541. Ya en la edad media la industria comenzó a tomar cierta importancia y dada la escasez de brazos, se vio obligado el patrón por fuerza de las circunstancias a prestar ayuda económica a los trabajadores incapacitados por una u otra causa. Los accidentes sucedidos en las industrias no se consideraban como de trabajo, por no conocerse el peligro que envolvía el empleo de la maqumana. En el siglo XVII y a principios del XVIII un médico italiano, Ramazzini habla del perjuicio que ocasionan ciertos trabajos en el organismo del individuo, produciendo alteraciones anatómicas y funcionales. Solamente a fines del siglo XVIII y a principios del XIX con la producción en masa, con el aumento del número de obreros y con la falta de protección, empezaron los accidentes de trabajo a hacerse notorios.

  15. Componente Cultura del Agua del PMGRH: plan de trabajo

    OpenAIRE

    Autoridad Nacional del Agua; Proyecto de Modernización de la Gestión de Recursos Hídricos

    2012-01-01

    Describe el plan de trabajo del Componente Cultura del Agua del Proyecto de Modernización de la Gestión de Recursos Hídricos (PMGRH) en relacion a dos aspectos estructurales del proyecto: 1. Mejora de la capacidad de la Gestión Integrada de Recursos Hídricos (GIRH) a nivel nacional y 2. Fortalecimiento de las capacidades de GIRH en las cuencas.

  16. Intervención de trabajo social con adultos mayores

    Directory of Open Access Journals (Sweden)

    Yesica Rodríguez Montañez

    2003-01-01

    Full Text Available El artículo presenta las metodologías de intervención del Trabajo Social con adultos mayores realizando un recorrido por los términos envejecimiento y vejez, haciendo énfasis en la importancia de la pérdida en la concepción de la misma . Se realiza un aná

  17. DOCUMENTO: FUNCIÓN Y PROFESIONALIDAD DEL TRABAJO SOCIAL

    Directory of Open Access Journals (Sweden)

    Cristina De Robertis

    2009-08-01

    Full Text Available Desde su surgimiento a fines del siglo XIX, la historia del Trabajo Social francés nos muestra períodos de creación y de transformación de la profesión. Durante las guerras del siglo XX los trabajadores sociales desplegaron capacidad de adaptación y de resistencia en esos períodos tan difíciles, sometidos a tensiones y decisiones éticas importantes. Después de Mayo del 68, el Trabajo Social fué criticado y analizado en términos de normalización y de control de la población, en su rol, según Althuser, de “aparato ideológico de Estado”. Pero el trabajo social asume también otras funciones, puesto que el costo del sufrimiento social es importante tanto en el plano económico que humano. Los trabajadores sociales invierten esfuerzo en mejorar las condiciones de vida de las personas y de los grupos y en luchar por mayor justicia social. El Trabajo Social enfrenta presiones contradictorias que debe asumir apoyándose en los valores éticos, en la deontología y en sus conocimientos teóricos y prácticos. Puede entonces articular las tres dimensiones del saber, saber hacer y saber ser (savoir, savoir faire, savoir être. La profesionalidad se construye en tensión constante entre las fuerzas internas y externas, entre los elementos de permanencia y los de cambio.

  18. LOS APORTES DEL TRABAJO SOCIAL AL TEMA DE FAMILIA

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    Angela María Quintero Velásquez

    2012-08-01

    Full Text Available El artículo presenta las contribuciones del Trabajo Social en los procesos familiares del continente. Refiere modalidades de la acción tales como: economapa. formas alternativas de enfrentar los conflictos socio-familiares, grupos psicoeducativos, redes. Precisa algunos elementos de la intervención: constructivismo, enfoque de convergencia (interinstitucionalidad, intersectorialidad, interdisciplinariedad, cibernética, relaciones ecosistemicas. la familia como sistema social.

  19. Control y supervisión de los trabajos verticales

    OpenAIRE

    Sirvent Pérez, César Daniel

    2012-01-01

    El siguiente artículo aborda una serie de conceptos relacionados con los trabajos verticales, desde el punto de vista del técnico encargado de controlar las obras (antes del inicio) y supervisar (durante el transcurso) en las que intervengan equipos de operarios especialistas. Su autor es el Arquitecto Técnico César Daniel Sirvent, director de la Oficina Técnica Altur y profesor de la Universidad de Alicante.

  20. Determinantes sociales de la salud y el trabajo informal

    OpenAIRE

    Consuelo Vélez Álvarez; María del Pilar Escobar Potes; María Eugenia Pico Merchán

    2013-01-01

    Objetivo: Describir elementos teóricos sobre los determinantes sociales de la salud en la población trabajadora informal y condiciones sociales, modos de vida y repercusiones en el proceso salud-enfermedad. Estrategia de búsqueda: Búsqueda sistemática en bases de datos especializadas (Ovid, Proquest, Hinary, Medline, LILACS, Literatura gris). Se utilizaron las siguientes palabras claves: condiciones sociales, factores socioeconómicos, fuerza de trabajo, empleo; de igual forma se retoman texto...

  1. Habilidades sociales en entornos virtuales de trabajo colaborativo

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    Nallilda Villasana

    2007-12-01

    Full Text Available Este estudio se incluye dentro de la temática de investigación de las Tecnologías de la Información y la Comunicación, el diseño e implementación de metodologías de aprendizaje colaborativo y la promoción de habilidades sociales en estudiantes de nivel superior. El estudio fue de tipo exploratorio y se inserta dentro de los propósitos de la investigación preexperimental. Se administró un tratamiento al grupo y se midieron varias variables para observar el aprendizaje logrado a partir de la aplicación de una metodología de trabajo colaborativo basado en el Aprendizaje por Proyectos, la opinión de los estudiantes sobre la importancia del trabajo colaborativo y las habilidades sociales que evidenciaron a través del entorno virtual utilizado. Los resultados mostraron que una metodología de trabajo colaborativo basada en el aprendizaje por proyectos y mediada a través de un entorno virtual, promueve el desarrollo de habilidades sociales de conversación, y de aceptación y oposición asertiva en los estudiantes.

  2. Flexibilidad laboral: ¿fin del trabajo permanente?

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    Carmen Añez Hernández

    2016-05-01

    Full Text Available Los trabajos transitorios o atípicos, siguen posicionándose y funcionando trastocando la protección del sistema de regulación y protección del trabajo permanente. De ahí, la importancia de reflexionar teóricamente sobre el tema. Para su desarrollo se plantean los siguientes objetivos: demostrar que la flexibilización laboral ha incidido en la ruptura de las relaciones laborales, caracterizar como la subcontratación laboral encubre dichas relaciones, analizar el despido laboral y sus consecuencias en los trabajadores. El artículo se desarrolló teóricamente, especialmente tomando como referencia autores como: Bravo (2010, Quintero (2010, González (2012 De La Garza (2007, Ugarte (2007, entre otros, lo cual permitió analizar la temática abordada. Los resultados reflejan que dicha estrategia está impulsando la agudización de las condiciones precarias de los derechos laborales, con lo cual se está ante un capitalismo irracional, que tiene como propósito que los trabajadores sufraguen los efectos de las pretensiones de los capitalistas por conseguir mayores tasas de ganancia y niveles más altos de productividad. En consecuencia, la flexibilización de las relaciones laborales está destinada a ocultar los derechos de los trabajadores, agudizar el despido laboral, y propiciar el fin de un trabajo permanente.

  3. ENCIERRO, TRABAJO Y LIBERTAD. RELATO DE OPORTUNIDADES GANADAS Y PERDIDAS

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    Mariana Cecilia Fernández

    2016-08-01

    Full Text Available Este trabajo se propone rastrear los elementos que estructuran la vida de Julián, un hombre de 47 años que se “gana la vida” vendiendo copos de azúcar en Morón, como parte de una tesis doctoral en curso que analiza las políticas públicas de “inclusión social” dirigidas a personas liberadas de prisión durante el proceso post-penitenciario en la ciudad de Buenos Aires en la actualidad. Las siguientes líneas se proponen abrir el campo de exploración referido al delito y la sociedad a partir de los repertorios experienciales y asuntos significativos de su biografía.El trabajo se segmenta en dos partes: 1 el tiempo (eterno del encierro; 2 el trabajo como tranquilidad y la libertad como no rutina. Dos momentos en que podrían dividirse las “oportunidades” de su vida. He aquí el punto recurrente en torno al cual fue y vino el relato de Julián durante el transcurso de dos entrevistas en profundidad realizadas recientemente. La oportunidad, como una suerte de intersticio cuasi voluntario que no se halla distribuido en partes iguales ni todos llegan a alcanzar. Y que confirma, una y otra vez, la inexistencia de la justicia.

  4. Salud, trabajo e informalidad en el Cauca, Colombia

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    Augusto Muñoz C

    2013-03-01

    Full Text Available Objetivo: describir las condiciones de salud y trabajo de las personas ocupadas en el sector informal del comercio, en cinco municipios del departamento del Cauca, durante el año 2011. Metodología: estudio descriptivo, transversal, desarrollado con 223 sujetos a quienes se les aplicó una encuesta estandarizada a nivel nacional. Resultados: la mayoría (80% de la población está asegurada en salud, pero no a pensiones ni a riesgos profesionales. Más del 70% tiene acceso a telefonía celular, acueducto y energía, pero baja cobertura del servicio de gas y alcantarillado. El 60% manifestó tener una buena salud y más del 50% percibió su lugar de trabajo como un lugar seguro para trabajar. El grupo que mejor se siente con el trabajo que realiza es el de vendedores de leche (92,3%. Discusión: los resultados obtenidos en cuanto al sexo, edad, estado civil y nivel educativo, entre otros, coinciden con los arrojados por un estudio desarrollado a nivel nacional con la misma población. Se encontró que en los municipios incluidos en este estudio no se ha promovido la conformación de Grupos Organizados de Trabajadores Informales, lo cual puede impedir su organización y la mejoría de sus condiciones

  5. [es] Los conocimientos en trabajo social: elogio del eclecticismo

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    Jean-Pierre Deslauriers

    2010-06-01

    Full Text Available La ciencia está en el origen del trabajo social. En efecto, el objetivo que perseguía Mary Richmond al conceptualizar la disciplina de trabajo social consistía en reemplazar las creencias religiosas por un enfoque racional. Así pues, el conocimiento científico se inscribe en el corazón del trabajo social desde el principio. Dicho esto, las grandes teorías son menos útiles en la práctica de una profesión cuya finalidad es ayudar a las personas que viven las situaciones más diversas. Esta es la razón por la cual el trabajo social se construye a partir de una base ecléctica: el trabajador social eficaz toma de un vasto conjunto de nociones, en apariencia dispares, aquellas que mejor se adaptan a la situación. Ahora bien, ¿cómo enseñar este conocimiento práctico a los estudiantes de trabajo social? Este artículo trata de estas cuestiones y propone algunas pistas de reflexión. Science is closely related to social work, from its very origin. In fact, with the conceptualization of social work, Mary Richmond’s objective was to replace religious beliefs by a more rational approach. Thus, right from its beginning, the scientific knowledge was at the core of social work. This being said, grand theories are less appropriate to the practice of social work because this profession deals with persons living in particular situations. That is why social work is built upon an eclectic basis : social worker has to draw from a vast array of notions and theories to borrow bits and pieces which will help to explain and attenuate problem experienced by persons. Now, this practical knowledge can be taught to students in social work? This article deals with these questions and proposes some reflections.

  6. Salud y condiciones de trabajo en trabajadores mayores

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    Elena Ordaz Castillo

    2015-09-01

    Full Text Available Introducción: En los últimos años, la población española ha experimentado un crecimiento acelerado de personas mayores. Las previsiones demográficas a corto-medio plazo describen un importante predominio de trabajadores mayores en el mercado laboral. Objetivos: Identificar las diferencias según dos grupos de edad (55 años en la percepción de las condiciones de trabajo y salud de la población trabajadora española. Metodología: Las diferencias entre los dos grupos de edad se analizaron a partir de indicadores de condiciones de trabajo y de salud pertenecientes a la VII Encuesta Nacional de Condiciones de Trabajo del Instituto de Seguridad e Higiene en el Trabajo (VII_ENCT. El análisis consistió en el cálculo de las prevalencias y la odds ratio cruda-ORc y ajustada por sexo con su correspondiente intervalo del confianza al 95%. Resultados: El grupo de trabajadores más jóvenes presentan más riesgo de exposición a seis de los siete indicadores relacionados con las condiciones de trabajo (ruido, vibraciones, carga física, carga mental, autonomía y motivación. No obstante los trabajadores mayores tienen una peor percepción de su estado de salud (ORa= 2,06 [1,75-2,42] y presentan en mayor medida problemas de salud que si bien les conducen a la visita médica más frecuentemente los relacionan menos con su actividad laboral. Conclusiones: A tenor de los resultados, los trabajadores de 55 años y más refieren tener menos quejas respecto a sus condiciones laborales e incluso se sienten más autónomos y motivados. Es el deterioro físico y mental la principal limitación que encuentran estos trabajadores a la hora de ejercer sus tareas. Sería recomendable establecer políticas de promoción de la salud dentro de las empresas para mejorar los indicadores de salud y promover el envejecimiento activo de la población trabajadora española.

  7. New times for Trabajos de Prehistoria (2010 - 2013

    Directory of Open Access Journals (Sweden)

    Montero Ruíz, Ignacio

    2010-12-01

    Full Text Available The new editorial and advisory boards present their editorial line and policy for the next four-year cycle. We maintain the subject coverage, languages of publications and standards of quality that have brought Trabajos de Prehistoria international recognition. New features include the adoption of the open source software, Open Journal System, as the management system, the suppression of the embargo starting with issue 67(2 2010, and the possibility of publishing monographic issues, as agreed by the Editorial Board, following the criteria of other journals of impact. We update the norms for the presentation of original manuscripts and include a detailed style sheet. We acknowledge the vital contribution of peer reviewers to the current positioning of the Journal as a landmark in its subject coverage within and beyond the Iberian Peninsula. The reviews will now follow a double-blind procedure. We also express our gratitude to those responsible for Electronic Publishing for their assistance and advice in increasing the visibility of Trabajos de Prehistoria.

    El nuevo equipo editorial presenta las líneas generales de su gestión. Se mantiene la temática, lenguas de publicación y estándares de calidad, base del reconocimiento y valoración internacional de Trabajos de Prehistoria. Se introducen novedades como incorporar la gestión de la Revista al programa libre de gestión Open Journal System, suprimir el embargo desde el número 67 (2 2010 y la posibilidad de publicar números monográficos por decisión del Consejo de Redacción, siguiendo el criterio de otras revistas de impacto. Se renuevan las normas para los autores incluyendo una hoja de estilo. Se reconoce el papel esencial jugado por los evaluadores y evaluadoras en la situación actual de referencia alcanzada por la Revista dentro y fuera de la Península Ibérica en su ámbito temático. Su revisión se ajustará ahora al procedimiento doble ciego. Igualmente se agradece a los

  8. Viral infection drives tissue fibrosis in vitro

    Directory of Open Access Journals (Sweden)

    Andrea P. Malizia

    2008-04-01

    Full Text Available Idiopathic Pulmonary Fibrosis (IPF is a refractory and lethal interstitial lung disease characterized by loss of alveolar epithelial cells, fibroblast proliferation and extra-cellular matrix protein deposition. EBV, localised to alveolar epithelial cells of pulmonary fibrosis patients is associated with a poor prognosis. In this study we utilised a microarray-based differential gene expression analysis strategy to identify molecular drivers of EBV associated with lung fibrosis. A549 cells and an alveolar epithelial cell line infected with EBV (VAAK were used to identify genes whose expression was altered by EBV reactivation. EBV reactivation by TGFbeta1 drives alterations in expression of non-canonical Wnt pathway mediators, implicating it in epithelial mesenchymal transition (EMT, the molecular event underpinning scar production in tissue fibrosis. Cell invasion, EMT correlated transcripts expression, GSK-3b and c-Jun activation were altered in response to non-canonical Wnt pathway regulation. The role of EBV in promoting fibrosis can be attenuated by antiviral strategies and inhibition of Wnt signalling. Activation of non-canonical Wnt signalling pathway by EBV in epithelial cells suggests a novel mechanism of tissue fibrosis. These data present a framework for further description of the link between infectious agents and fibrosis, a significant disease burden.

  9. Inhaled mannitol for cystic fibrosis.

    Science.gov (United States)

    Nevitt, Sarah J; Thornton, Judith; Murray, Clare S; Dwyer, Tiffany

    2018-02-09

    Several agents are used to clear secretions from the airways of people with cystic fibrosis. Mannitol increases mucociliary clearance, but its exact mechanism of action is unknown. The dry powder formulation of mannitol may be more convenient and easier to use compared with established agents which require delivery via a nebuliser. Phase III trials of inhaled dry powder mannitol for the treatment of cystic fibrosis have been completed and it is now available in Australia and some countries in Europe. This is an update of a previous review. To assess whether inhaled dry powder mannitol is well tolerated, whether it improves the quality of life and respiratory function in people with cystic fibrosis and which adverse events are associated with the treatment. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises references identified from comprehensive electronic databases, handsearching relevant journals and abstracts from conferences.Date of last search: 28 September 2017. All randomised controlled studies comparing mannitol with placebo, active inhaled comparators (for example, hypertonic saline or dornase alfa) or with no treatment. Authors independently assessed studies for inclusion, carried out data extraction and assessed the risk of bias in included studies. The quality of the evidence was assessed using GRADE. Six studies (reported in 50 publications) were included with a total of 784 participants.Duration of treatment in the included studies ranged from 12 days to six months, with open-label treatment for an additional six months in two of the studies. Five studies compared mannitol with control (a very low dose of mannitol or non-respirable mannitol) and the final study compared mannitol to dornase alfa alone and to mannitol plus dornase alfa. Two large studies had a similar parallel design and provided data for 600 participants, which could be pooled where data for a particular outcome and time point were

  10. Nanoparticles for the treatment of liver fibrosis

    Directory of Open Access Journals (Sweden)

    Poilil Surendran S

    2017-09-01

    Full Text Available Suchithra Poilil Surendran, Reju George Thomas, Myeong Ju Moon, Yong Yeon Jeong Department of Radiology, BioMolecular Theranostics (BiT Lab, Chonnam National University Medical School, Chonnam National University Hwasun Hospital (CNUHH, South Korea Abstract: Chronic liver diseases represent a global health problem due to their high prevalence worldwide and the limited available curative treatment options. They can result from various causes, both infectious and noninfectious diseases. The application of nanoparticle (NP systems has emerged as a rapidly evolving area of interest for the safe delivery of various drugs and nucleic acids for chronic liver diseases. This review presents the pathogenesis, diagnosis and the emerging nanoparticulate systems used in the treatment of chronic liver diseases caused by liver fibrosis. Activated hepatic stellate cell (HSC is considered to be the main mechanism for liver fibrosis. Ultrasonography and magnetic resonance imaging techniques are widely used noninvasive diagnostic methods for hepatic fibrosis. A variety of nanoparticulate systems are mainly focused on targeting HSC in the treatment of hepatic fibrosis. As early liver fibrosis is reversible by current NP therapy, it is being studied in preclinical as well as clinical trials. Among various nanoparticulate systems, inorganic NPs, liposomes and nanomicelles have been widely studied due to their distinct properties to deliver drugs as well as other therapeutic moieties. Liposomal NPs in clinical trials is considered to be a milestone in the treatment of hepatic fibrosis. Currently, NP therapy for liver fibrosis is updating fast, and hopefully, it can be the future remedy for liver fibrosis. Keywords: liver fibrosis, inorganic nanoparticles, liposomes, micelles

  11. Vitamin A supplementation for cystic fibrosis.

    Science.gov (United States)

    Bonifant, Catherine M; Shevill, Elizabeth; Chang, Anne B

    2014-05-14

    People with cystic fibrosis and pancreatic insufficiency are at risk of fat soluble vitamin deficiency as these vitamins (A, D, E and K) are co-absorbed with fat. Thus, some cystic fibrosis centres routinely administer these vitamins as supplements but the centres vary in their approach of addressing the possible development of deficiencies in these vitamins. Vitamin A deficiency causes predominantly eye and skin problems while supplementation of vitamin A to excessive levels may cause harm to the respiratory and skeletal systems in children. Thus a systematic review on vitamin A supplementation in people with cystic fibrosis would help guide clinical practice. To determine if vitamin A supplementation in children and adults with cystic fibrosis:1. reduces the frequency of vitamin A deficiency disorders;2. improves general and respiratory health;3. increases the frequency of vitamin A toxicity. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Date of the most recent search of the Group's Cystic Fibrosis Trials Register: 07 April 2014. All randomised or quasi-randomised controlled trials comparing all preparations of oral vitamin A used as a supplement compared to either no supplementation (or placebo) at any dose and for any duration, in children or adults with cystic fibrosis (defined by sweat tests or genetic testing) with and without pancreatic insufficiency. No relevant studies for inclusion were identified in the search. No studies were included in this review. As there were no randomised or quasi-randomised controlled trials identified, we cannot draw any conclusions on the benefits (or otherwise) of regular administration of vitamin A in people with cystic fibrosis. Until further data are available, country or region specific guidelines on the use of

  12. Voice Disorder in Cystic Fibrosis Patients

    Science.gov (United States)

    Lourenço, Bruna Mendes; Costa, Kauê Machado; da Silva Filho, Manoel

    2014-01-01

    Cystic fibrosis is a common autosomal recessive disorder with drastic respiratory symptoms, including shortness of breath and chronic cough. While most of cystic fibrosis treatment is dedicated to mitigating the effects of respiratory dysfunction, the potential effects of this disease on vocal parameters have not been systematically studied. We hypothesized that cystic fibrosis patients, given their characteristic respiratory disorders, would also present dysphonic symptoms. Given that voice disorders can severely impair quality of life, the identification of a potential cystic fibrosis-related dysphonia could be of great value for the clinical evaluation and treatment of this disease. We tested our hypothesis by measuring vocal parameters, using both objective physical measures and the GRBAS subjective evaluation method, in male and female cystic fibrosis patients undergoing conventional treatment and compared them to age and sex matched controls. We found that cystic fibrosis patients had a significantly lower vocal intensity and harmonic to noise ratio, as well as increased levels of jitter and shimmer. In addition, cystic fibrosis patients also showed higher scores of roughness, breathiness and asthenia, as well as a significantly altered general grade of dysphonia. When we segregated the results according to sex, we observed that, as a group, only female cystic fibrosis patients had significantly lower values of harmonic to noise ratio and an abnormal general grade of dysphonia in relation to matched controls, suggesting that cystic fibrosis exerts a more pronounced effect on vocal parameters of women in relation to men. Overall, the dysphonic characteristics of CF patients can be explained by dysfunctions in vocal fold movement and partial upper airway obstruction, potentially caused by the accumulation of mucus and chronic cough characteristic of CF symptomatology. Our results show that CF patients exhibit significant dysphonia and suggest they may

  13. Cambios morfológicos, celulares y moleculares en la fibrosis renal debido al envejecimiento

    Directory of Open Access Journals (Sweden)

    Miguel Alaga

    2015-11-01

    Full Text Available En los últimos 50 años se ha registrado un aumento gradual de la tasa de envejecimiento de la población uruguaya, reflejándose en un incremento de pacientes con enfermedad renal crónica mayores de 65 años. Este fenómeno plantea la interrogante de cómo el envejecimiento tisular afecta la función del riñón y, en particular cómo contribuye al desarrollo de la fibrosis renal. Con el envejecimiento se producen cambios morfológicos y funcionales en el riñón, tales como la esclerosis glomerular y la fibrosis intersticial. Estos cambios son consecuencia de alteraciones que ocurren a nivel celular. En este trabajo se profundizará en los mecanismos celulares que desencadenan la fibrosis intersticial y la gloméruloesclerosis, describiendo el proceso de inflamación sostenida, la transformación fenotípica de las células epiteliales a miofibroblastos, así como los mecanismos de producción de matriz extracelular y la perpetuación de la fibrosis renal. Además, detallaremos las cascadas moleculares involucradas en el proceso de fibrosis, poniendo énfasis en las cascadas reguladas por TGF-β1 y sus vías de interacción, que regulan la producción factores pro- y anti-fibróticos. También veremos como el TGF-β1 modula la expresión de ARN pequeños no-codificantes (microARNs, potentes inhibidores de la expresión génica, y como el gen anti-envejecimiento Klotho inhibe el avance de la fibrosis renal. Finalmente, discutiremos terapias para frenar o enlentecer el proceso de fibrosis renal, especialmente aquellas que tengan como blanco las cascadas de señalización activadas por TGF-β1, los microRNAs y posibles terapias de activación del gen Klotho para prevenir la progresión de esta patología.

  14. Vitamin D deficiency as a risk factor for cystic fibrosis-related diabetes in the Scandinavian Cystic Fibrosis Nutritional Study

    DEFF Research Database (Denmark)

    Pincikova, T; Nilsson, Kristine Kahr; Moen, I E

    2011-01-01

    Many cystic fibrosis patients are vitamin D-insufficient. Cystic fibrosis-related diabetes is a major complication of cystic fibrosis. The literature suggests that vitamin D might possess certain glucose-lowering properties. We aimed to assess the relationship between vitamin D and cystic fibrosis...

  15. Formación de jóvenes para el trabajo: escolaridad, capacitación y trabajo infantil

    Directory of Open Access Journals (Sweden)

    Ibarrola María de

    2003-01-01

    Full Text Available El estudio al cual se refiere este artículo es parte de um projecto amplio de investigación realizado con en el proposito de analizar la formación de los jóvenes para el trabajo en una ciudad mexicana, que se orientó a conocer las múltiples maneras como esta se resuelve. En ese sentido fueron abordadas las politicas públicas y privadas que impulsan la formación para el trabajo juvenil, las instituciones y sistemas de educación que intervienen y los actores envolucrados. El ojetivo de este artículo es describir y analizar especificamente las tres vias de formación en la industria del calzado: la escolaridad, la capacitación intencional impartida en el interior de la empresa y los conocimientos y competencias adquiridos por los trabajadores a través de sus experiencias más o menos intencionales, en los diversos centros de trabajo. Se proponen finalmente algunos puntos básicos de debate al respecto.

  16. Combined Pulmonary Fibrosis and Emphysema Syndrome

    Science.gov (United States)

    Rounds, Sharon I. S.

    2012-01-01

    There is increasing clinical, radiologic, and pathologic recognition of the coexistence of emphysema and pulmonary fibrosis in the same patient, resulting in a clinical syndrome known as combined pulmonary fibrosis and emphysema (CPFE) that is characterized by dyspnea, upper-lobe emphysema, lower-lobe fibrosis, and abnormalities of gas exchange. This syndrome frequently is complicated by pulmonary hypertension, acute lung injury, and lung cancer. The CPFE syndrome typically occurs in male smokers, and the mortality associated with this condition, especially if pulmonary hypertension is present, is significant. In this review, we explore the current state of the literature and discuss etiologic factors and clinical characteristics of the CPFE syndrome. PMID:22215830

  17. Transient elastography for liver fibrosis diagnosis

    DEFF Research Database (Denmark)

    Andersen, Ellen Sloth; Christensen, Peer Brehm; Weis, Nina

    2008-01-01

    Liver biopsy is considered the "golden standard" for assessment of hepatic fibrosis. However, the procedure has limitations because of inconvenience and rare but serious complications as bleeding. Furthermore, sampling errors are frequent, and interobserver variability often poses problems....... Recently, a modified ultrasound scanner (transient elastography) has been developed to assess fibrosis. The device measures liver elasticity, which correlates well with the degree of fibrosis. Studies have shown that transient elastography is more accurate in diagnosing cirrhosis than minor to moderate...... to be a valuable diagnostic procedure and follow-up of patients with chronic liver diseases....

  18. Transient elastography for liver fibrosis diagnosis

    DEFF Research Database (Denmark)

    Andersen, Ellen Sloth; Christensen, Peer Brehm; Weis, Nina

    2009-01-01

    Liver biopsy is considered the "golden standard" for assessment of hepatic fibrosis. However, the procedure has limitations because of inconvenience and rare but serious complications as bleeding. Furthermore, sampling errors are frequent, and interobserver variability often poses problems....... Recently, a modified ultrasound scanner (transient elastography) has been developed to assess fibrosis. The device measures liver elasticity, which correlates well with the degree of fibrosis. Studies have shown that transient elastography is more accurate in diagnosing cirrhosis than minor to moderate...... to be a valuable diagnostic procedure and follow-up of patients with chronic liver diseases....

  19. Cough in idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Mirjam J.G. van Manen

    2016-09-01

    Full Text Available Many patients with idiopathic pulmonary fibrosis (IPF complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably “multifactorial” and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF.

  20. Pathogenesis of Idiopathic Pulmonary Fibrosis

    Science.gov (United States)

    Wolters, Paul J.; Collard, Harold R.; Jones, Kirk D.

    2014-01-01

    Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease associated with aging that is characterized by the histopathological pattern of usual interstitial pneumonia. Although an understanding of the pathogenesis of IPF is incomplete, recent advances delineating specific clinical and pathologic features of IPF have led to better definition of the molecular pathways that are pathologically activated in the disease. In this review we highlight several of these advances, with a focus on genetic predisposition to IPF and how genetic changes, which occur primarily in epithelial cells, lead to activation of profibrotic pathways in epithelial cells. We then discuss the pathologic changes within IPF fibroblasts and the extracellular matrix, and we conclude with a summary of how these profibrotic pathways may be interrelated. PMID:24050627

  1. Retroperitoneal fibrosis: findings with MR

    International Nuclear Information System (INIS)

    Martinez Rodrigo, J.; Marti-Bonnati, L.; Diago, T.; Ferrer, M.D.; Aleixandre, A.; Morote, V.

    1993-01-01

    Retroperitoneal fibrosis (RF) is an uncommon disease characterized by the presence of a chronic inflammatory reaction, with the formation of fibrous tissue that replaces the normal retroperitoneal tissue, trapping vessels and/or ureters. We present a retrospective review of 3 cases of idiopathic RF studied by means of ultrasound, CT scan and MR imaging, and we assess the features of the MR image, as well as its capacity for characterizing the lesion. We compare the findings obtained with 3 imaging techniques, describing the utility of each one, and their advantages and disadvantages in the assessment of this pathology. In MR, idiopathic RF appears as a hypodense mass in SET1, SE-T2 and STIR sequences. (Author) 9 ref

  2. Del trabajo al paro y del paro al subsidio: Cambios en las culturas del trabajo de los jornaleros andaluces

    Directory of Open Access Journals (Sweden)

    Palenzuela, Pablo

    2000-12-01

    Full Text Available The author analyzes the gradual loss of social identity of Andalusian day laborers through the combined effects of the modernization of agradan structures and goverment subsidies for temporary workers. The thread of the author's analysis is the concept of work cultures and their role in the formation of social identities. With this epistemological instrument, he reconstructs the material basis of the work processes (i. e., the knowhow, the technical organization, the control systems as well as the day laborers' representations of their job (i. e., their values, symbols, perceptions, etc. within the context of specific relations of production. As the bases of reproduction of those work cultures disappear, so do the day laborers as a self-conscious social group, who then become no more than an administrative category, earmarked for government handouts. They are made redundant by the mechanization of agriculture, yet have no future in the productive economy.Se analiza el proceso de disolución de la identidad social de los jornaleros andaluces a partir de los efectos combinados de la política de modernización de las estructuras agrarias y las prestaciones asistenciales para los trabajadores eventuales. El hilo conductor del análisis es el concepto de culturas del trabajo y su nivel de determinación en la configuración de las identidades sociales. Con esta herramienta epistemológica se reconstruye la base material (técnicas y saberes, organización técnica y sistemas de control de los procesos de trabajo, así como el conjunto de representaciones (valores, símbolos, percepciones, etc. que los jornaleros han asignado a su trabajo en unas determinadas relaciones sociales de producción. Al desaparecer las bases de reproducción de esas culturas del trabajo, los jornaleros se disuelven como colectivo identitario para transformarse en una simple categoría administrativa, convirtiéndose en asistidos sociales que subsisten de las prestaciones

  3. La actitud hacia el trabajo del personal administrativo en el Núcleo Humanístico de la Universidad del Zulia

    Directory of Open Access Journals (Sweden)

    Marysol Ansa P.

    2008-01-01

    Full Text Available El objetivo del artículo es determinar la actitud hacia el trabajo presente en el personal administrativo del Núcleo Humanístico de LUZ. El estudio realizado fue descriptivo, con un diseño de investigación no experimental- transeccional, de campo. Se aplicó un muestreo aleatorio simple y se obtuvo una muestra de setenta y tres (73 sujetos. Como instrumento para la recolección de información se utilizó un cuestionario tipo escala Likert, cuya confiabilidad fue de 97,2%. Los resultados obtenidos reflejan que en el personal administrativo existe un compromiso con la institución y una participación en el trabajo; sin embargo no todos los empleados están satisfechos con su trabajo en lo que respecta a las condiciones físicas que existen, la remuneración y las recompensas que reciben. Por lo tanto, se puede concluir que en el personal administrativo que integra el Núcleo Humanístico de LUZ está presente una actitud con tendencia positiva o favorable hacia el trabajo y la institución; no obstante, es necesario tomar medidas para mejorar el aspecto relacionado con la satisfacción laboral.

  4. Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis

    International Nuclear Information System (INIS)

    Van Beneden, Katrien; Geers, Caroline; Pauwels, Marina; Mannaerts, Inge; Wissing, Karl M.; Van den Branden, Christiane; Grunsven, Leo A. van

    2013-01-01

    Histone deacetylase (HDAC) inhibitors are promising new compounds for the therapy of fibrotic diseases. In this study we compared the effect of two HDAC inhibitors, trichostatin A and valproic acid, in an experimental model of kidney fibrosis. In mice, doxorubicin (adriamycin) can cause nephropathy characterized by chronic proteinuria, glomerular damage and interstitial inflammation and fibrosis, as seen in human focal segmental glomerulosclerosis. Two treatment regimens were applied, treatment was either started prior to the doxorubicin insult or delayed until a significant degree of proteinuria and fibrosis was present. Pre-treatment of trichostatin A significantly hampered glomerulosclerosis and tubulointerstitial fibrosis, as did the pre-treatment with valproic acid. In contrast, the development of proteinuria was only completely inhibited in the pre-treated valproic acid group, and not in the pre-treated trichostatin A animals. In the postponed treatment with valproic acid, a complete resolution of established doxorubicin-induced proteinuria was achieved within three days, whereas trichostatin A could not correct proteinuria in such a treatment regimen. However, both postponed regimens have comparable efficacy in maintaining the kidney fibrosis to the level reached at the start of the treatments. Moreover, not only the process of fibrosis, but also renal inflammation was attenuated by both HDAC inhibitors. Our data confirm a role for HDACs in renal fibrogenesis and point towards a therapeutic potential for HDAC inhibitors. The effect on renal disease progression and manifestation can however be different for individual HDAC inhibitors. - Highlights: • Valproic acid is a potent antiproteinuric drug, whereas trichostatin A is not. • Trichostatin A and valproic acid reduce kidney fibrosis in doxorubicin nephropathy. • Both valproic acid and trichostatin A attenuate renal inflammation

  5. Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Van Beneden, Katrien, E-mail: kvbenede@vub.ac.be [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Geers, Caroline [Department of Pathology, Universitair Ziekenhuis Brussel, Brussels (Belgium); Pauwels, Marina [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Mannaerts, Inge [Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Wissing, Karl M. [Department of Nephrology, Universitair Ziekenhuis Brussel, Brussels (Belgium); Van den Branden, Christiane [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Grunsven, Leo A. van, E-mail: lvgrunsv@vub.ac.be [Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium)

    2013-09-01

    Histone deacetylase (HDAC) inhibitors are promising new compounds for the therapy of fibrotic diseases. In this study we compared the effect of two HDAC inhibitors, trichostatin A and valproic acid, in an experimental model of kidney fibrosis. In mice, doxorubicin (adriamycin) can cause nephropathy characterized by chronic proteinuria, glomerular damage and interstitial inflammation and fibrosis, as seen in human focal segmental glomerulosclerosis. Two treatment regimens were applied, treatment was either started prior to the doxorubicin insult or delayed until a significant degree of proteinuria and fibrosis was present. Pre-treatment of trichostatin A significantly hampered glomerulosclerosis and tubulointerstitial fibrosis, as did the pre-treatment with valproic acid. In contrast, the development of proteinuria was only completely inhibited in the pre-treated valproic acid group, and not in the pre-treated trichostatin A animals. In the postponed treatment with valproic acid, a complete resolution of established doxorubicin-induced proteinuria was achieved within three days, whereas trichostatin A could not correct proteinuria in such a treatment regimen. However, both postponed regimens have comparable efficacy in maintaining the kidney fibrosis to the level reached at the start of the treatments. Moreover, not only the process of fibrosis, but also renal inflammation was attenuated by both HDAC inhibitors. Our data confirm a role for HDACs in renal fibrogenesis and point towards a therapeutic potential for HDAC inhibitors. The effect on renal disease progression and manifestation can however be different for individual HDAC inhibitors. - Highlights: • Valproic acid is a potent antiproteinuric drug, whereas trichostatin A is not. • Trichostatin A and valproic acid reduce kidney fibrosis in doxorubicin nephropathy. • Both valproic acid and trichostatin A attenuate renal inflammation.

  6. Aspects of Reactor Physics Research at the Victoria University of Manchester; Quelques Aspects des Experiences de Physique des Reacteurs a l'Universite Victoria de Manchester; Aspekty ehksperimental'nykh issledovanij po fizike reaktorov v universitete viktorii v manchestere; Trabajos de Fisica Experimental con Reactores Efectuados en la Universidad Victoria de Manchester

    Energy Technology Data Exchange (ETDEWEB)

    Harris, M. J.; Walton, D. G. [Victoria University of Manchester (United Kingdom)

    1964-02-15

    The Nuclear Engineering Department at Manchester University was established in 1959. Since that time post-graduate reactor physics studies have gradually enlarged and developed, starting virtually from scratch; experimental studies have concentrated on light-water systems and centred on the accelerator-driven, natural-uranium, light-water exponential. The paper contains a survey of the work to date, discussion of the results obtained, outlines of proposed future work, and, as they arise in the text, descriptions of various low-cost, labour-saving experimental techniques which have been adopted. The various divisions of the work are described below. The authors have studied neutron diffusion in light water using both pulsed source and steady source methods. In the former method they have particularly stressed full harmonic analysis to the extent of actually studying the higher modes as opposed to most former work which has tried only to eliminate them. In the study of steady source methods they have concentrated on eliminating all effects from finite source and detector size, resonance activation, flux perturbation and so on. The results of both are discussed and compared. A very careful measurement of absorption cross-sections by the pulsed technique, taking care to eliminate harmonic and other effects likely to lead to error is also in progress and is described. Thermal neutron spectra in ''poisoned'' light water are being measured as a means of investigating and developing integral detector techniques. This discussion includes some interesting time- and cost-saving examples. Large foil activation and counting techniques for measuring spatially averaged neutron densities, and hence a number of reactor parameters, have been studied. Some interesting points have arisen, particularly with regard to spectrum measurement. The method makes possible many reactor physics investigations with limited resources. A low-cost natural uranium, light-water exponential has been

  7. Accidentes de trabajo en un hospital de agudos

    Directory of Open Access Journals (Sweden)

    Pérez Bermúdez B.

    1998-01-01

    Full Text Available FUNDAMENTO: El mejor conocimiento de los determinantes y circunstancias de producción de los accidentes laborales, favorecerá la implantación de medidas correctoras. El objetivo de este trabajo es describir la evolución temporal de los accidentes de trabajo (AT y determinar los factores de riesgo de baja médica en el Hospital Dr. Peset de Valencia. MÉTODOS: Descripción y análisis retrospectivo de los accidentes de trabajo producidos en el Hospital Dr. Peset de Valencia durante los años 1992 a 1995. Se estimó por métodos deterministas la tendencia y estacionalidad de las series (índices estacionales, IE. Se aplicó un modelo de regresión logística para identificar los factores pronósticos de baja médica y determinar su probabilidad de ocurrencia . RESULTADOS: Las tasas más elevadas de AT se produjeron entre los trabajadores de cocina y lavandería (10,00 AT por 100 trabajadores-año. Los AT con baja médica mantienen una tendencia cercana a cero siendo febrero el mes con I.E más elevado (IE=139,8. Los que cursan sin baja médica tienen una tendencia positiva (r²=0,23, p<0,0001, siendo mayo el mes de mayor siniestralidad (IE=134,2. La probabilidad de que el accidente curse con baja médica aumenta significativamente con la edad, cuando se produce por la tarde, si ha tenido lugar en cocina/lavandería, y si se trata de un esguince o tendinitis. CONCLUSIONES: la actuación sobre la siniestralidad en los AT que cursen con IT, debería centrarse sobre los trabajos menos cualificados y en las áreas de cocina y lavandería.

  8. Organizaciones para el siglo XXI: grupos de trabajo autogestionados.

    Directory of Open Access Journals (Sweden)

    Luis Avendaño Fernández

    2013-11-01

    Full Text Available En la actualidad, muchas empresas exitosas están dejando atrás los esquemas rígidos y autoritarios de organización y orientan sus esfuerzos hacia la formación de equipos autogestionados que integran el logro de los objetivos de eficiencia, rentabilidad y crecimiento que requiere la empresa, con el logro de los objetivos individuales y grupales de desarrollo humano. En Colombia las OTAS (Organizaciones de Trabajo Asociado poseen características de grupos autodirigidos que la empresa debe conocer y adoptar con el fin de conservar su participación en el mercado.

  9. Resúmenes de los trabajos sobre las Enfermedades Neuromusculares

    OpenAIRE

    Congreso Nacional de Neurología

    2010-01-01

    Las enfermedades neuromusculares constituyen un conjunto de afectaciones que afectan las neuronas motoras periférica, las vías motoras eferentes o los efectores (músculos esqueléticos). Sus manifestaciones clínicas son muy variadas y dependen de la causa y de los niveles de afectación. En este acápite se pueden encontrar los resúmenes de trabajos relacionados con el síndrome de Guillain Barre, polineuropatía diabética, Atrofia Muscular Espinal, Distrofia miotónica y otros todos presentados en...

  10. Medidas preventivas de seguridad e higiene en el trabajo

    Directory of Open Access Journals (Sweden)

    Adrian Vázquez Garza

    2013-05-01

    Full Text Available En la actualidad, las nuevas tecnologías y la creciente demanda de productos en un mundo globalizado hacen que las empresas exijan más a sus empleados. En esta situación laboral se toma importancia a los riesgos de trabajo. Estos, debido a que toda acción conlleva un riesgo, por lo cual es de suma importancia contar con un departamento que prevea, analice, realice pruebas y cree normas de seguridad e higiene en el área laboral. Los autores concluyen que la creación de un departamento de seguridad es indispensable para garantizar la seguridad de los trabajadores.

  11. Trabajo infantil y problemas del comportamiento en menores trabajadores

    OpenAIRE

    Cardenas Ramirez, Luz Stella

    2016-01-01

    Objetivo: Identificar la relación de los factores de riesgo ocupacional del trabajo infantil con los problemas de comportamiento en menores de edad trabajadores de una plaza de mercado en Colombia Materiales y métodos: Se realizó un estudio de corte transversal con 100 niños trabajadores de la plaza de Mercaneiva. Se aplicó un cuestionario para evaluar los factores ocupacionales en la población, evaluando aspectos sociodemográficos y condiciones laborales; para establecer la prevalencia d...

  12. Reconocimiento jurídico y social del trabajo penoso

    OpenAIRE

    Haase de Miranda, Anelise

    2016-01-01

    En la obra Trabajadores, el fotógrafo brasileño Sebastião Salgado, expone 350 fotos de actividades que él mismo ha calificado de "trabajo duro y penoso ". Se trata de una categoría ya olvidada o, al menos, se aborda de forma insuficiente en el derecho laboral. Este desequilibrio cuantitativo existente entre lo que el artista retrató como actividades en condiciones de penosidad, el respectivo tratamiento teórico , la praxis y las legislaciones jurídico-laborales, hace que nos planteemos las ra...

  13. Molecular and cellular mechanisms of pulmonary fibrosis

    Science.gov (United States)

    2012-01-01

    Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary fibrosis is considered the most common and severe form of the disease, with a median survival of approximately three years and no proven effective therapy. Despite the fact that effective treatments are absent and the precise mechanisms that drive fibrosis in most patients remain incompletely understood, an extensive body of scientific literature regarding pulmonary fibrosis has accumulated over the past 35 years. In this review, we discuss three broad areas which have been explored that may be responsible for the combination of altered lung fibroblasts, loss of alveolar epithelial cells, and excessive accumulation of ECM: inflammation and immune mechanisms, oxidative stress and oxidative signaling, and procoagulant mechanisms. We discuss each of these processes separately to facilitate clarity, but certainly significant interplay will occur amongst these pathways in patients with this disease. PMID:22824096

  14. Imaging findings in idiopathic pelvic fibrosis

    International Nuclear Information System (INIS)

    Wiesner, W.; Bongartz, G.; Stoffel, F.

    2001-01-01

    Two patients presented with ureteric obstruction, and voiding symptoms and constipation, respectively, and were examined by means of intravenous urography and computed tomography. One patient was additionally examined by means of MR tomography. After CT (performed in both patients) and MRT (performed in one patient) had shown a diffuse, contrast-enhancing, infiltrating process in the small pelvis with infiltration of adjacent organs and vessels, surgical biopsy proved the diagnosis of idopathic pelvic fibrosis. Extension of retroperitoneal fibrosis below the pelvic rim is very rare. Clinical symptoms of pelvic fibrosis are variable and imaging findings may lead to a broad list of differential diagnoses. We present two patients with idiopathic pelvic fibrosis and discuss radiological findings and differential diagnoses of this rare disease. (orig.)

  15. European Cystic Fibrosis Society Standards of Care

    DEFF Research Database (Denmark)

    Stern, Martin; Bertrand, Dominique Pougheon; Bignamini, Elisabetta

    2014-01-01

    Since the earliest days of cystic fibrosis (CF) treatment, patient data have been recorded and reviewed in order to identify the factors that lead to more favourable outcomes. Large data repositories, such as the US Cystic Fibrosis Registry, which was established in the 1960s, enabled successful ...... to indicators of health, the role of CF Centres, regional networks, national health policy, and international data registration and comparisons.......Since the earliest days of cystic fibrosis (CF) treatment, patient data have been recorded and reviewed in order to identify the factors that lead to more favourable outcomes. Large data repositories, such as the US Cystic Fibrosis Registry, which was established in the 1960s, enabled successful...... therapies, approaches to care and indeed data recording. The quality of care for individuals with CF has become a focus at several levels: patient, centre, regional, national and international. This paper reviews the quality management and improvement issues at each of these levels with particular reference...

  16. Liver Fibrosis: Current Principles of Diagnosis

    Directory of Open Access Journals (Sweden)

    A.K. Duda

    2014-09-01

    Full Text Available Liver fibrosis — a natural consequence of almost all liver diseases of any origin. We are faced with a number of standard stereotype processes that take place in the liver tissue. Mostly it is the processes of chronic inflammation, which oppose the processes of liver tissue regeneration. The basis of imbalance between the processes of fibrosis and regeneration is an accumulation of extracellular matrix. Liver fibrosis in its development leads to liver cirrhosis, hepatocellular carcinoma, and the increase in morbidity rate is observed worldwide. Furthermore, the process is genetically determined, but modifiable factors play an important role in the progression of this disease. Current data indicate the possibility of reversible liver fibrosis.

  17. Imaging findings in idiopathic pelvic fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Wiesner, W.; Bongartz, G. [Inst. of Diagnostic Radiology University Hospital Basel (Switzerland); Stoffel, F. [Inst. of Urology, University Hospital Basel (Switzerland)

    2001-04-01

    Two patients presented with ureteric obstruction, and voiding symptoms and constipation, respectively, and were examined by means of intravenous urography and computed tomography. One patient was additionally examined by means of MR tomography. After CT (performed in both patients) and MRT (performed in one patient) had shown a diffuse, contrast-enhancing, infiltrating process in the small pelvis with infiltration of adjacent organs and vessels, surgical biopsy proved the diagnosis of idopathic pelvic fibrosis. Extension of retroperitoneal fibrosis below the pelvic rim is very rare. Clinical symptoms of pelvic fibrosis are variable and imaging findings may lead to a broad list of differential diagnoses. We present two patients with idiopathic pelvic fibrosis and discuss radiological findings and differential diagnoses of this rare disease. (orig.)

  18. Nutrition in Cystic Fibrosis: Macro- and Micronutrients

    NARCIS (Netherlands)

    Oudshoorn, Johanna Hermiena

    2006-01-01

    Cystic fibrosis (CF) is the most common life-threatening autosomal recessive inherited disease in Caucasians, and is characterized by progressive lung disease, pancreatic insufficiency, malnutrition, hepatobiliary disease and elevated sweat electrolyte levels. The increased survival of CF patients

  19. [Regulation of airway stem cell proliferation in idiopathic pulmonary fibrosis].

    Science.gov (United States)

    Yang, S X; Wu, Q; Sun, X; Li, X; Li, K; Xu, L; Li, Y; Zhang, Q Y; Zhang, Y C; Chen, H Y

    2016-09-01

    To investigate the effect of fibroblasts on regulating airway stem cell proliferation in idiopathic pulmonary fibrosis. Lung cell suspension was prepared from β-actin-GFP mice. Airway stem cells were obtained by fluorescence activated cell sorting and co-cultured with lung fibroblasts. The fibroblasts were treated with TGF-β inhibitor SB43142. The expression of growth factors FGF1/2 and the effect of FGF1/2 on stem cell proliferation were observed. The cloning efficiency of airway stem cells, when co-cultured with normal lung fibroblast cells for 8 days, was (3.5±1.1)%, while the cloning efficiency was reduced to (0.04±0.04)% when co-cultured with lung fibroblasts from idiopathic pulmonary fibrosis patients. The difference between the 2 groups was statistically significant(P=0.002 5). TGF-β receptor inhibitor SB431542 increased lung fibroblast growth factors FGF1/2 expression.FGF1 mRNA expression was increased to the experimental group 0.005 5 from 0.000 2 in the control group.FGF2 mRNA expression of the amount raised to the experimental group 0.000 15 from 0.000 8 in the control group.FGF1/2 promoted the growth of airway stem cells. After FGF1/2 was co-cultured with normal lung fibroblast cells for 8 days, the cloning efficiency of airway stem cells was (0.3±0.1)%. During the development of idiopathic pulmonary fibrosis, fibroblast secreted FGF1/2 regulate airway stem cell proliferation.

  20. Drug- and radiation-induced pulmonary fibrosis

    International Nuclear Information System (INIS)

    Uthgenannt, H.

    1976-01-01

    These two forms of pulmonary fibrosis which according to their type have nothing to do with one another, are presented as they are well suited to clarify the problems of the diagnosis of pulmonary fibrosis which is not a fixed concept for the pathologists. The frequent discrepancy found between the subjective clinical symptoms, clinical findings and X-ray and morphological pictures is indicated. (MG) [de

  1. Festival food coma in cystic fibrosis.

    Science.gov (United States)

    Pandit, Chetan; Graham, Christie; Selvadurai, Hiran; Gaskin, Kevin; Cooper, Peter; van Asperen, Peter

    2013-07-01

    Children with cystic fibrosis liver disease and portal hypertension are at risk of developing acute hepatic encephalopathy. Even in the presence of normal synthetic liver function these children may have porto-systemic shunting. We report a case of an adolosecent who had cystic fibrosis liver disease and presented with life threatening hepatinc encephalopathy. This case illustrates that it is necessary to consider an appropriate dietary regimen in adolosecents with liver disease to prevent hepatic decompensation. Copyright © 2012 Wiley Periodicals, Inc.

  2. Acute rejection after kidney transplantation promotes graft fibrosis with elevated adenosine level in rat.

    Directory of Open Access Journals (Sweden)

    Mingliang Li

    Full Text Available Chronic allograft nephropathy is a worldwide issue with the major feature of progressive allograft fibrosis, eventually ending with graft loss. Adenosine has been demonstrated to play an important role in process of fibrosis. Our study aimed to investigate the relationship between adenosine and fibrosis in renal allograft acute rejection in rat.Wistar rats and SD rats were selected as experimental animals. Our study designed two groups. In the allograft transplantation group, kidneys of Wistar rats were orthotopically transplanted into SD rat recipients, the same species but not genetically identical, to induce acute rejection. Kidney transplantations of SD rats to SD rats which were genetically identical were served as the control. We established rat models and detected a series of indicators. All data were analyzed statistically. P<0.05 was considered statistically significant.Compared with the control group, levels of adenosine increased significantly in the allograft transplantation group, in which acute rejection was induced (P<0.05. Progressive allograft fibrosis as well as collagen deposition were observed.These findings suggested that level of adenosine was upregulated in acute rejection after kidney allograft transplantation in rat. Acute rejection may promote renal allograft fibrosis via the adenosine signaling pathways.

  3. Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats

    Directory of Open Access Journals (Sweden)

    Atef M. Al-Attar

    2017-05-01

    Full Text Available The current study was designed to investigate the possible protective effect of omega-3 fatty acids from fish oil on hepatic fibrosis induced by thioacetamide (TAA in male rats. The experimental animals were divided into four groups. The first group was received saline solution and served as control. The second group was given 250 mg/kg body weight of TAA. The third group was treated with omega-3 fatty acids and TAA. The fourth group was given saline solution and supplemented with omega-3 fatty acids. Treatment of rats with TAA for three and six weeks resulted in a significant decrease in body weight gain, while the value of liver/body weight ratio was statistically increased. Furthermore, the levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase and total bilirubin were significantly increased. After three weeks of exposure to only TAA, liver sections showed an abnormal morphology characterized by noticeable fibrosis with the extracellular matrix collagen contents and damage of liver cells’ structure. Liver sections from rats treated with only TAA for six weeks revealed an obvious increase in extracellular matrix collagen content and bridging fibrosis. Treating TAA-intoxicated rats with omega-3 fatty acids significantly attenuated the severe physiological and histopathological changes. Finally, the present investigation suggests that omega-3 fatty acids could act against hepatic fibrosis induced by TAA due to its antioxidant properties, thus supporting its use in hepatic fibrosis therapy.

  4. Zinc supplementation suppresses the progression of bile duct ligation-induced liver fibrosis in mice.

    Science.gov (United States)

    Shi, Fang; Sheng, Qin; Xu, Xinhua; Huang, Wenli; Kang, Y James

    2015-09-01

    Metallothionein (MT) gene therapy leads to resolution of liver fibrosis in mouse model, in which the activation of collagenases is involved in the regression of liver fibrosis. MT plays a critical role in zinc sequestration in the liver suggesting its therapeutic effect would be mediated by zinc. The present study was undertaken to test the hypothesis that zinc supplementation suppresses liver fibrosis. Male Kunming mice subjected to bile duct ligation (BDL) resulted in liver fibrosis as assessed by increased α-smooth muscle actin (α-SMA) and collagen I production/deposition in the liver. Zinc supplementation was introduced 4 weeks after BDL surgery via intragastric administration once daily for 2 weeks resulting in a significant reduction in the collagen deposition in the liver and an increase in the survival rate. Furthermore, zinc suppressed gene expression of α-SMA and collagen I and enhanced the capacity of collagen degradation, as determined by the increased activity of total collagenases and elevated mRNA and protein levels of MMP13. Therefore, the results demonstrate that zinc supplementation suppresses BDL-induced liver fibrosis through both inhibiting collagen production and enhancing collagen degradation. © 2014 by the Society for Experimental Biology and Medicine.

  5. Digital quantification of fibrosis in liver biopsy sections: description of a new method by Photoshop software.

    Science.gov (United States)

    Dahab, Gamal M; Kheriza, Mohamed M; El-Beltagi, Hussien M; Fouda, Abdel-Motaal M; El-Din, Osama A Sharaf

    2004-01-01

    The precise quantification of fibrous tissue in liver biopsy sections is extremely important in the classification, diagnosis and grading of chronic liver disease, as well as in evaluating the response to antifibrotic therapy. Because the recently described methods of digital image analysis of fibrosis in liver biopsy sections have major flaws, including the use of out-dated techniques in image processing, inadequate precision and inability to detect and quantify perisinusoidal fibrosis, we developed a new technique in computerized image analysis of liver biopsy sections based on Adobe Photoshop software. We prepared an experimental model of liver fibrosis involving treatment of rats with oral CCl4 for 6 weeks. After staining liver sections with Masson's trichrome, a series of computer operations were performed including (i) reconstitution of seamless widefield images from a number of acquired fields of liver sections; (ii) image size and solution adjustment; (iii) color correction; (iv) digital selection of a specified color range representing all fibrous tissue in the image and; (v) extraction and calculation. This technique is fully computerized with no manual interference at any step, and thus could be very reliable for objectively quantifying any pattern of fibrosis in liver biopsy sections and in assessing the response to antifibrotic therapy. It could also be a valuable tool in the precise assessment of antifibrotic therapy to other tissue regardless of the pattern of tissue or fibrosis.

  6. Automatic liver volume segmentation and fibrosis classification

    Science.gov (United States)

    Bal, Evgeny; Klang, Eyal; Amitai, Michal; Greenspan, Hayit

    2018-02-01

    In this work, we present an automatic method for liver segmentation and fibrosis classification in liver computed-tomography (CT) portal phase scans. The input is a full abdomen CT scan with an unknown number of slices, and the output is a liver volume segmentation mask and a fibrosis grade. A multi-stage analysis scheme is applied to each scan, including: volume segmentation, texture features extraction and SVM based classification. Data contains portal phase CT examinations from 80 patients, taken with different scanners. Each examination has a matching Fibroscan grade. The dataset was subdivided into two groups: first group contains healthy cases and mild fibrosis, second group contains moderate fibrosis, severe fibrosis and cirrhosis. Using our automated algorithm, we achieved an average dice index of 0.93 ± 0.05 for segmentation and a sensitivity of 0.92 and specificity of 0.81for classification. To the best of our knowledge, this is a first end to end automatic framework for liver fibrosis classification; an approach that, once validated, can have a great potential value in the clinic.

  7. Relación epitelio-conectivo en la carcinogénesis experimental bucal: variaciones de ploidía epitelial en relación a la expresión del factor de crecimiento fibroblástico-básico y fibrosis

    OpenAIRE

    Raimondi, Ana Rosa

    2003-01-01

    El modelo de la bolsa de la mejilla del hámster muy aceptado y utilizado, reproduce la cancerización de la boca humana y una fibrosis subepitelial semejante a la fibrosis de la submucosa. En el se han analizado extensamente las características de los tumores que produce, pero se ha prestado menos atención al estudio de las etapas previas a la aparición de tumores. Las neoplasias que se observan en el modelo se dan en forma focal, precedidas por lesiones pre-malignas muitifocales, en una clara...

  8. TRABAJO Y CUERPO. EL CASO DE LOS HOMBRES ENFERMEROS

    Directory of Open Access Journals (Sweden)

    ALFONSO HERNÁNDEZ RODRÍGUEZ

    2011-01-01

    Full Text Available La división sexual del trabajo establece espacios y afecta de diferente manera a hombres y mujeres, orienta papeles, permea la elección de carrera, etcétera, marcando la actividad de unos y otras como una extensión de los roles de género. Aquí se indaga, desde la perspectiva de género, si los hombres tienen desventajas o ventajas al laborar en un empleo considerado tradicionalmente "femenino", la segregación sexual en el trabajo y la carga simbólica que tienen el cuerpo y la masculinidad como un privilegio, resultado del llamado "dividendo patriarcal". En el caso de los enfermeros, al ocupar un espacio sexuado que "no les corresponde", enfrentan sanciones sociales, según el régimen de género establecido; pero, el hecho de ser varones también los privilegia por encima de esa sanción social.

  9. Compromiso laboral del trabajo social en el sector salud

    Directory of Open Access Journals (Sweden)

    Javier Carreón Guillén

    2015-01-01

    Full Text Available En virtud de que el trabajo social está inmerso en políticas públicas y programas sociales que van dirigidos a grupos vulnerables, marginados o excluidos, es menester analizar su compromiso considerando su relación con la gestión para el tratamiento de enfermedades y la rehabilitación en instituciones del sector salud. En tal sentido, el objetivo del presente estudio fue establecer la confiabilidad y validez de un instrumento que mide el compromiso laboral en el sector salud. Para tal propósito, se utilizó una muestra no probabilística de 125 profesionales del trabajo social con experiencia en implementación de programas sociales y seguimiento de estrategias institucionales para la promoción de la salud. Se establecieron la normalidad, confiabilidad y validez de la escala que midió el compromiso laboral; además de un modelo estructural reflejante en el que el compromiso hacia la institución se relacionó positivamente con el compromiso laboral. Los índices de ajuste y residual corroboraron la hipótesis de multidimensionalidad del compromiso laboral.

  10. El trabajo migratorio de indocumentados en México

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    María de Lourdes González Chávez

    2009-01-01

    Full Text Available Este artículo analiza las antinomias legales entre la Ley general de población y la Ley federal del trabajo en perjuicio de los inmigrantes que, por alguna razón, trabajan en México sin autorización legal para hacerlo. Para ello, se estudian los antecedentes de las leyes federales invocadas, la política del Estado mexicano ante los trabajadores ilegales y su posición oficial contradictoria, al reconocer internacionalmente el trabajo como un derecho inherente al hombre, violentándolo al aplicar las leyes nacionales. Finalmente se pretende ver, en la aplicación del artículo 67 de la ley de población citada, una violación de derechos laborales de los trabajadores que, no obstante tener una condición ilegal de inmigrantes, realizan en México una actividad productiva legal y lícita.

  11. ANÁLISIS INTRODUCTORIO AL MERCADO DUAL DE TRABAJO

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    Julio Cesar Riascos

    2007-07-01

    Full Text Available En el artículo se examina el fenómeno de la informalidad a la luz del modelo dual del mercado de trabajo. Con ese objetivo, se ilustra al lector, cómo a partir de la dinámica suscitada en el sector formal de la economía laboral, se desprenden efectos simultáneos en la plataforma informal de trabajo. En particular, se estudia el impacto de un incremento en los salarios reales, ambos casos a través de una externalidad originada en acciones de política económica gubernamental; a juzgar por sus efectos, se conviene la existencia de un estrecho vínculo entre las dos partes a través de sus interacciones; en ese mismo sentido, se reconoce la trascendencia del mercado informal en el sostenimiento de la tesis neoclásica de pleno empleo y, se advierte como tarea indispensable la redefinición del concepto de formalidad y subempleo, dadas por supuesto sus implicaciones, esta última parte posibilita estructurar una crítica social al modelo.

  12. Estructura Factorial del Cuestionario de Condiciones de Trabajo

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    Josep M. Blanch

    2010-01-01

    Full Text Available El Cuestionario de Condiciones de Trabajo fue diseñado y aplicado como una herramienta de evaluación de componentes psicosociales del entorno laboral en organizaciones de servicio a personas. Lo contestaron 1252 profesionales de la sanidad (medicina y enfermería y de la educación superior empleados respectivamente en hospitales y en universidades de diversos países iberoamericanos. Este cuestionario incluye series de ítems cerrados organizados de acuerdo con un modelo teórico según el cual las condiciones de trabajo se configuran en torno a una triple relación de la organización con el método, con el entorno y con la persona. Un análisis de componentes principales mostró la existencia de seis factores en el cuestionario, agrupados por pares en tres grupos de escalas, mostrando todas ellas una notable consistencia interna, con altos valores α de Cronbach. El estudio psicométrico indica que el cuestionario reproduce fielmente la estructura del modelo teórico propuesto.

  13. Marco de trabajo para gestionar las competencias laborales

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    Franklin Sandoval

    2014-12-01

    Full Text Available En este artículo se presenta un marco de trabajo innovador diseñado y desarrollado para posibilitar la realización de estudios inherentes con la gestión por competencia en los entornos laborales de la Administración Pública Venezolana (APV. Se analizaron los principales aspectos involucrados con la Gestión del Talento Humano (GTH, que se basan en la competencia laboral, las cuales mediante su desarrollo efectivo se constituyen en fuente principal para impulsar el logro de los objetivos empresariales orientados en responder las necesidades del entorno laboral y las exigencias del mercado. El desarrollo, se fundamento en el dominio del conocimiento de las competencias laborales y perfiles de cargos que estructura el proceso de gestión sobre tres actividades: 1 identificación, 2 desarrollo y 3 evaluación. El método utilizado, fue proyectivo y permitió obtener un marco de trabajo en el que se describe una metodología, la cual establece formalmente las reglas, estándares, así como secuencias de pasos para la caracterización de la competencia laboral y, sobre todo, la gestión que promueve las tareas y roles para la toma de decisiones.

  14. Gene therapy in cystic fibrosis.

    Science.gov (United States)

    Flotte, T R; Laube, B L

    2001-09-01

    Theoretically, cystic fibrosis transmembrane conductance regulator (CFTR) gene replacement during the neonatal period can decrease morbidity and mortality from cystic fibrosis (CF). In vivo gene transfers have been accomplished in CF patients. Choice of vector, mode of delivery to airways, translocation of genetic information, and sufficient expression level of the normalized CFTR gene are issues that currently are being addressed in the field. The advantages and limitations of viral vectors are a function of the parent virus. Viral vectors used in this setting include adenovirus (Ad) and adeno-associated virus (AAV). Initial studies with Ad vectors resulted in a vector that was efficient for gene transfer with dose-limiting inflammatory effects due to the large amount of viral protein delivered. The next generation of Ad vectors, with more viral coding sequence deletions, has a longer duration of activity and elicits a lesser degree of cell-mediated immunity in mice. A more recent generation of Ad vectors has no viral genes remaining. Despite these changes, the problem of humoral immunity remains with Ad vectors. A variety of strategies such as vector systems requiring single, or widely spaced, administrations, pharmacologic immunosuppression at administration, creation of a stealth vector, modification of immunogenic epitopes, or tolerance induction are being considered to circumvent humoral immunity. AAV vectors have been studied in animal and human models. They do not appear to induce inflammatory changes over a wide range of doses. The level of CFTR messenger RNA expression is difficult to ascertain with AAV vectors since the small size of the vector relative to the CFTR gene leaves no space for vector-specific sequences on which to base assays to distinguish endogenous from vector-expressed messenger RNA. In general, AAV vectors appear to be safe and have superior duration profiles. Cationic liposomes are lipid-DNA complexes. These vectors generally have been

  15. Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice.

    LENUS (Irish Health Repository)

    Robb, W B

    2010-03-01

    The amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine\\'s effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy.

  16. El teatro en el trabajo popular. La eficacia, un desafío para el trabajo popular

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    Ana Hirsz

    2015-01-01

    Full Text Available Todas las personas e instituciones dedicadas al trabajo popular se plantean la necesidad de la eficacia en su labor. ¿Cómo, de qué manera ser más útiles a los sectores populares? ¿Qué instrumentos les pueden servir para la acción transformadora que deben realizar? Estas preguntas han generado una multiplicidad de métodos, de formas, de técnicas. El Centro al Servicio de la Acción Popular (CESAP en 17 años de trabajo incesante ha creado una metodología inductiva y participativa que, a través de diferentes áreas, intenta generar el desarrollo de las potencialidades y capacidades del pueblo. El Servicio de Comunicación y Cultura Popular constituye otra herramienta ofrecida por CESAP a los grupos y organizaciones populares, pues capacita a los grupos para que ellos estén en condiciones de producir sus propios medios de comunicación comunitarios, con fines de información, concientización y movilización de las comunidades. Junto a esa finalidad organízatíva, estos Talleres estimulan la autoexpresión y la creatividad popular y el desarrollo de una cultura propia y transformadora.

  17. Condiciones de trabajo que impactan en la vida laboral

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    Laura Martínez Buelvas

    2013-01-01

    Full Text Available Objetivo:Proponer un esquema de clasificación conceptual (ECC basado en el método de análisis de contenidos, con el fin determinar brechas en el conocimiento en cuanto a las variables de condiciones de trabajo que impactan la Calidad de Vida Laboral. Materiales y métodos: Seutilizó una metodología integral de clasificación que considera 54 artículos científicos comprendidos en el periodo 1992 - 2012, a partir de los cuales se estructuraron diferentes categorías, tales como: año de publicación del artículo, titulo de la revista científica en la cual se publicó y un esquema conceptual basado en preguntas. Resultados:Las investigaciones relacionadas con el tema de estudio han aumentado en la última década. El total de artículos revisados aumentó de 6 en el período 1992 - 2001 a 48 en el período 2002 - 2012. Por otra parte, el 76 % de los artículos analizados llega a la conclusión de que existe una estrecha relación entre las condiciones de trabajo analizadas y el impacto en la salud física y mental de los trabajadores. No obstante, con un porcentaje del 9 % diferentes investigaciones exponen la relación entre las condiciones favorables de trabajo y el incremento en la productividad. Conclusiones: Los avances realizados en el campo han dado frutos y actualmente se están estimando nuevas metodologías y/o herramientas que permitan evaluar las condiciones a las que están expuestos los trabajadores, y de esta manera involucrarlos a conseguir no solo los objetivos financieros y de operaciones de la empresa, sino también los beneficios en pro de su desarrollo personal y profesional.

  18. Male fertility in cystic fibrosis.

    LENUS (Irish Health Repository)

    Chotirmall, S H

    2011-04-05

    Infertility rates among males with cystic fibrosis (CF) approximate 97%. No information is currently available within Ireland determining an understanding of fertility issues and the best methods of information provision to this specialized group. This study aimed to determine understanding and preferred approaches to information provision on fertility issues to Irish CF males. A Descriptive Study utilizing prospective coded questionnaires was mailed to a male CF cohort (n=50). Sections included demographics, fertility knowledge & investigation. Response rate was 16\\/50 (32%). All were aware that CF affected their fertility. More than two-thirds (n=11) were able to provide explanations whilst only one-third (n=5) provided the correct explanation. Significant numbers stated thoughts of marriage and a future family. Half have discussed fertility with a healthcare professional (HCP). Mean age of discussion was 21.9 years. One third preferred an earlier discussion. The commonest first source for information was written material which was also the preferred source. Three-quarters requested further information preferring again, written material. Significant gaps in sex education of Irish CF males exist. Discussion should be initiated by HCPs and centre-directed written material devised to address deficiencies.

  19. Cystic fibrosis: a clinical view.

    Science.gov (United States)

    Castellani, Carlo; Assael, Baroukh M

    2017-01-01

    Cystic fibrosis (CF), a monogenic disease caused by mutations in the CFTR gene on chromosome 7, is complex and greatly variable in clinical expression. Airways, pancreas, male genital system, intestine, liver, bone, and kidney are involved. The lack of CFTR or its impaired function causes fat malabsorption and chronic pulmonary infections leading to bronchiectasis and progressive lung damage. Previously considered lethal in infancy and childhood, CF has now attained median survivals of 50 years of age, mainly thanks to the early diagnosis through neonatal screening, recognition of mild forms, and an aggressive therapeutic attitude. Classical treatment includes pancreatic enzyme replacement, respiratory physiotherapy, mucolitics, and aggressive antibiotic therapy. A significant proportion of patients with severe symptoms still requires lung or, less frequently, liver transplantation. The great number of mutations and their diverse effects on the CFTR protein account only partially for CF clinical variability, and modifier genes have a role in modulating the clinical expression of the disease. Despite the increasing understanding of CFTR functioning, several aspects of CF need still to be clarified, e.g., the worse outcome in females, the risk of malignancies, the pathophysiology, and best treatment of comorbidities, such as CF-related diabetes or CF-related bone disorder. Research is focusing on new drugs restoring CFTR function, some already available and with good clinical impact, others showing promising preliminary results that need to be confirmed in phase III clinical trials.

  20. Pneumothorax and idiopathic pulmonary fibrosis

    International Nuclear Information System (INIS)

    Iwasawa, Tae; Ogura, Takashi; Takahashi, Hiroshi; Asakura, Akira; Gotoh, Toshiyuki; Yazawa, Takuya; Inoue, Tomio

    2010-01-01

    We evaluated the relation between the severity of idiopathic pulmonary fibrosis (IPF) and the incidence of pneumothorax on computed tomography (CT) images. In this retrospective study, we evaluated the presence of pneumothorax in 56 consecutive patients who died of IPF from the initial CT to death. We quantitatively analyzed a total of 207 CT images and measured the volume of the normal pattern (N-pattern) and each lesion pattern on the initial CT and their serial changes. The effects of pneumothorax and clinical and CT features on survival were evaluated using Cox regression analysis. Pneumothorax occurred in 17 of 56 patients. Comparison of the pneumothorax (+) and (-) groups showed the initial vital capacity (VC) was lower (P=0.005) and the follow-up period was shorter (P=0.03) in the former group. The decrease in the N-pattern volume in the pneumothorax (+) group was significantly faster than in the pneumothorax (-) group (P=0.013). Cox regression analyses identified a rapid decrease in N-pattern volume (P=0.008) and a rapid decrease in VC (P=0.002), but not pneumothorax, as significant predictors of poor survival. Pneumothorax in IPF patients is associated with lower VC and rapid deterioration of CT findings. The findings suggest that pneumothorax is a complication of advanced IPF. (author)

  1. Liver Disease in Cystic Fibrosis: an Update

    Science.gov (United States)

    Parisi, Giuseppe Fabio; Di Dio, Giovanna; Franzonello, Chiara; Gennaro, Alessia; Rotolo, Novella; Lionetti, Elena; Leonardi, Salvatore

    2013-01-01

    Context Cystic fibrosis (CF) is the most widespread autosomal recessive genetic disorder that limits life expectation amongst the Caucasian population. As the median survival has increased related to early multidisciplinary intervention, other manifestations of CF have emergedespecially for the broad spectrum of hepatobiliary involvement. The present study reviews the existing literature on liver disease in cystic fibrosis and describes the key issues for an adequate clinical evaluation and management of patients, with a focus on the pathogenetic, clinical and diagnostic-therapeutic aspects of liver disease in CF. Evidence Acquisition A literature search of electronic databases was undertaken for relevant studies published from 1990 about liver disease in cystic fibrosis. The databases searched were: EMBASE, PubMed and Cochrane Library. Results CF is due to mutations in the gene on chromosome 7 that encodes an amino acidic polypeptide named CFTR (cystic fibrosis transmembrane regulator). The hepatic manifestations include particular changes referring to the basic CFTR defect, iatrogenic lesions or consequences of the multisystem disease. Even though hepatobiliary disease is the most common non-pulmonary cause ofmortalityin CF (the third after pulmonary disease and transplant complications), only about the 33%ofCF patients presents clinically significant hepatobiliary disease. Conclusions Liver disease will have a growing impact on survival and quality of life of cystic fibrosis patients because a longer life expectancy and for this it is important its early recognition and a correct clinical management aimed atdelaying the onset of complications. This review could represent an opportunity to encourage researchers to better investigate genotype-phenotype correlation associated with the development of cystic fibrosis liver disease, especially for non-CFTR genetic polymorphisms, and detect predisposed individuals. Therapeutic trials are needed to find strategies of

  2. Inteligencia y memoria de trabajo: la relación entre factor g, complejidad cognitiva y capacidad de procesamiento

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    Colom Roberto

    2001-01-01

    Full Text Available La psicologia experimental ha estudiado extensivamente las características de la memoria, mientras que la psicología correlacional ha actualizado las principales propiedades de la inteligencia. El acercamiento entre ambos enfoques se basa en el análisis de las relaciones entre un concepto nuclear de la memoria -- la memoria de trabajo -- y el principal ingrediente del concepto psicométrico de inteligencia -- el factor g. Las evidencias disponibles sugieren que las diferencias individuales en g podrían ser explicadas por los conceptos cognitivos de capacidad y de velocidad asociados a la memoria de trabajo. Esas evidencias sugieren nuevos modos de mejorar la inteligencia -- y, por tanto, los correlatos asociados a ella -- a través del incremento de la capacidad del sistema para procesar información de manera eficiente.

  3. Trabajo y postemancipación en Haití

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    Javier Laviña

    2015-02-01

    Full Text Available Este artículo analiza las estructuras sociales subyacentes a la Revolución haitiana, y cómo las aspiraciones diferentes de negros y mulatos durante la Revolución de independencia (1791-1804 se trasladaron al período postabolición. Pese a los cambios en la legislación agraria después de la independencia, el fracaso a la hora de proporcionar unas condiciones de trabajo adaptadas a las demandas de los trabajadores rurales haitianos se añadió a las dificultades y los obstáculos enfrentados por Haití en su intento por construir una nación próspera y en libertad.

  4. DOCUMENTO: LA PRACTICA PROFESIONAL EN EL PROGRAMA DE TRABAJO SOCIAL

    Directory of Open Access Journals (Sweden)

    Liliana Pérez Mendoza

    2001-08-01

    Full Text Available La Facultad de Ciencias Sociales y Educación a través del Departamento de Practicas y el programa de Trabajo Social de la misma proyectan la acción de los Trabajadores Sociales en formación en diferentes áreas temáticas a fin de propiciar en los diferentes contextos donde tiene lugar, un desarrollo social, humano y sostenible con la participación en diferentes comunidades de la ciudad y la región, de docentes y estudiantes, a través de’ estrategias de acción profesional como: diagnósticos participativos, programas / proyectos de integración comunitaria, de generación de ingresos, de Desarrollo a Organizacional, de fortalecimiento de vínculos familiares, de convivencia ciudadana y de Desarrollo Municipal.

  5. La gerencia aclarada en el trabajo del enfermero

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    Mendes Isabel Amélia Costa

    2002-01-01

    Full Text Available La gerencia aclarada presupone que todo individuo de prioridad a una conducta fuerte y determinada, en detrimento de una conducta pasiva. Presupone también una profunda preocupación con las cuestiones de la especie humana, los problemas éticos, la relación con la naturaleza, en fin, con el futuro del hombre. De esta forma, las autoras, basadas en los presupuestos subyacentes a la política de gerencia aclarada de Maslow(1, tienen el objetivo de centralizar este tipo de gerencia en el trabajo del enfermero. Creen que, a través de ésta reflexión los enfermeros podrán incorporar en su práctica nuevos valores, más sintonizados con la naturaleza humana.

  6. La gerencia aclarada en el trabajo del enfermero

    Directory of Open Access Journals (Sweden)

    Isabel Amélia Costa Mendes

    Full Text Available La gerencia aclarada presupone que todo individuo de prioridad a una conducta fuerte y determinada, en detrimento de una conducta pasiva. Presupone también una profunda preocupación con las cuestiones de la especie humana, los problemas éticos, la relación con la naturaleza, en fin, con el futuro del hombre. De esta forma, las autoras, basadas en los presupuestos subyacentes a la política de gerencia aclarada de Maslow(1, tienen el objetivo de centralizar este tipo de gerencia en el trabajo del enfermero. Creen que, a través de ésta reflexión los enfermeros podrán incorporar en su práctica nuevos valores, más sintonizados con la naturaleza humana.

  7. La integracion multisensorial afecta a la memoria de trabajo

    Directory of Open Access Journals (Sweden)

    Fabiano Botta

    2012-11-01

    Full Text Available La información proveniente de distintas modalidades sensoriales converge y se integra en perceptos unitarios. ¿Cómo afecta esta integración al funcionamiento de la memoria de trabajo? Datos recientes indican que los estímulos que combinan modalidades sensoriales diferentes (p.ej., visual y auditiva parecen captar la atención mejor que los estímulos auditivos y visuales por separado, y así consiguen introducirse en la memoria de forma particularmente efectiva. Esto conlleva un beneficio en su recuerdo posterior, lo que tiene implicaciones en muchos contextos aplicados, como es el caso de la educación, rehabilitación y conducción.

  8. El trabajo colaborativo y la inclusión social

    Directory of Open Access Journals (Sweden)

    Amelia Berenice Barragán de Anda

    2010-04-01

    Full Text Available En este artículo se incluyen algunas reflexiones sobre el trabajo colaborativo y el impacto que éste tiene en el proceso de aprendizaje, no sólo en cuanto a la aprehensión de contenidos teórico-académicos, sino también a la adquisición de habilidades digitales, reconocimiento de actitudes, desarrollo de destrezas y aptitudes útiles para ser buen estudiante y para mejorar la práctica profesional a través de la convivencia generada por el trabajo colaborativo. El aprendizaje colaborativo posibilita el desarrollo de saberes teóricos, prácticos y formativos. Estos últimos permiten enfrentar un mundo cambiante con pensamiento crítico, así como habilidades de relación y comunicación, tolerancia, respeto y disposición a escuchar. Estas competencias tienen su base en las interactividad intencionada con un propósito definido de colaboración. La educación a distancia, a través de las estrategias utilizadas en los ambientes virtuales, funciona para "acercar" a los usuarios, ya que facilitan las interacciones sociales, la creación de redes sin importar las barreras físicas, de horario y heterogeneidad cultural. El egresado de esta modalidad educativa se beneficia por desarrollar dominio disciplinar y competencias transversales, como seguridad profesional, autoconfianza, lucha contra las resistencias tecnológicas, imposición de retos y logro de objetivos.

  9. Biliary fibrosis in microsurgical extrahepatic cholestasis in the rat.

    Science.gov (United States)

    Sánchez-Patán, Fernando; Anchuelo, Raquel; Corcuera, María-Teresa; Casado, Isabel; Gómez-Aguado, Fernando; Aller, María-Angeles; Cruz, Arturo; Alonso, María-José; Arias, Jaime

    2008-01-01

    A new model of extrahepatic cholestasis, using a microsurgical technique, is performed as an alternative to the traditional model of the bile duct ligated-rat, in order to study the stage of fibrosis in the long-term. Male Wistar rats were divided into two groups: I (Sham-operated, n = 9) and II [Microsurgical Cholestasis (MC), n = 10]. After 4 weeks, portal pressure, types of portosystemic collateral circulation, mesenteric venous vasculopathy, hepatic function test, and liver histopathology were studied by using the Knodell index and fibrosis was determined by reticulin and Sirius red stains. The animals with MC presented portal hypertension with extrahepatic portosistemic collateral circulation, associated with mesenteric venous vasculopathy and increased plasma levels of bilirubin (6.30 +/- 1.80 vs. 0.22 +/- 0.37 mg/dL; P = 0.0001), alkaline phosphatase (293.00 +/- 82.40 vs. 126.30 +/- 33.42 U/L; P = 0.001), AST (380.00 +/- 78.50 vs. 68.33 +/- 11.74 IU/L; P = 0.0001), ALT (87.60 +/- 22.32 vs. 42.22 +/- 7.89 IU/L; P = 0.0001), and LDH (697.76 +/- 75.13 vs. 384.80 +/- 100.03 IU/L; P = 0.0001). On the contrary, plasma levels of albumin decreased (2.72 +/- 0.12 mg/dl vs. 2.99 +/- 0.10; P = 0.001). The microsurgical resection of the extrahepatic biliary tract in the rat produces an experimental model of hepatic inflammation, characterized by a high Knodell hepatic activity index (4), bile proliferation, and fibrosis.

  10. Pathogenic aspects and therapeutic avenues of intestinal fibrosis in Crohn's disease.

    Science.gov (United States)

    Zorzi, Francesca; Calabrese, Emma; Monteleone, Giovanni

    2015-12-01

    In Crohn's disease, one of the two major forms of inflammatory bowel diseases in human beings, persistent and chronic inflammation promotes fibrotic processes thereby facilitating formation of strictures, the most common indication for surgical intervention in this disorder. The pathogenesis of Crohn's disease-associated fibrosis is not fully understood, but variants of genes involved in the recognition of microbial components/products [e.g. CARD15 (caspase-activating recruitment domain 15) and ATG16L1 (autophagy-related 16-like 1)] are associated with this phenotype, and experimental evidence suggests that intestinal fibrosis results from an altered balance between deposition of ECM (extracellular matrix) and degradation of ECM by proteases. Studies have also contributed to identify the main phenotypic and functional alterations of cells involved in the fibrogenic process, as well as molecules that stimulate such cells to produce elevated amounts of collagen and other ECM-related proteins. In the present review, we assess the current knowledge about cellular and molecular mediators of intestinal fibrosis and describe results of recent studies aimed at testing the preventive/therapeutic effect of compounds in experimental models of intestinal fibrosis. © 2015 Authors; published by Portland Press Limited.

  11. Mechanical Ventilation–associated Lung Fibrosis in Acute Respiratory Distress Syndrome A Significant Contributor to Poor Outcome

    Science.gov (United States)

    Cabrera-Benitez, Nuria E.; Laffey, John G.; Parotto, Matteo; Spieth, Peter M.; Villar, Jesús; Zhang, Haibo; Slutsky, Arthur S.

    2016-01-01

    One of the most challenging problems in critical care medicine is the management of patients with the acute respiratory distress syndrome. Increasing evidence from experimental and clinical studies suggests that mechanical ventilation, which is necessary for life support in patients with acute respiratory distress syndrome, can cause lung fibrosis, which may significantly contribute to morbidity and mortality. The role of mechanical stress as an inciting factor for lung fibrosis versus its role in lung homeostasis and the restoration of normal pulmonary parenchymal architecture is poorly understood. In this review, the authors explore recent advances in the field of pulmonary fibrosis in the context of acute respiratory distress syndrome, concentrating on its relevance to the practice of mechanical ventilation, as commonly applied by anesthetists and intensivists. The authors focus the discussion on the thesis that mechanical ventilation—or more specifically, that ventilator-induced lung injury—may be a major contributor to lung fibrosis. The authors critically appraise possible mechanisms underlying the mechanical stress–induced lung fibrosis and highlight potential therapeutic strategies to mitigate this fibrosis. PMID:24732023

  12. Circulating CO3-610, a degradation product of collagen III, closely reflects liver collagen and portal pressure in rats with fibrosis

    Science.gov (United States)

    2011-01-01

    Background Hepatic fibrosis is characterized by intense tissue remodeling, mainly driven by matrix metalloproteinases. We previously identified CO3-610, a type III collagen neoepitope generated by matrix metalloproteinase (MMP)-9, and tested its performance as a fibrosis marker in rats with bile-duct ligation. In this study, we assessed whether CO3-610 could be used as a surrogate biomarker of liver fibrosis and portal hypertension in carbon tetrachloride-induced experimental fibrosis. Results For this study, 68 Wistar rats were used. Serum CO3-610 was measured by ELISA. Liver fibrosis was quantified by Sirius red staining. Serum hyaluronic acid (HA) was measured with a binding-protein assay. Gene expression of collagens I and III, Mmp2 and Mmp9, and tissue inhibitors of matrix metalloproteinase 1 (Timp1) and 2(Timp2) was quantified by PCR. Hemodynamic measurements were taken in a subgroup of animals. A close direct relationship was found between serum CO3-610 and hepatic collagen content (r = 0.78; P fibrosis (43.5 ± 3.3 ng/mL, P Liver Mmp9 expression increased significantly in fibrotic animals but decreased to control levels in cirrhotic ones. Conclusions Circulating CO3-610 behaves as a reliable indicator of hepatic remodeling and portal hypertension in experimental fibrosis. This peptide could ultimately be a useful marker for the management of liver disease in patients. PMID:21813019

  13. Proteome analysis of Radiation-induced pulmonary fibrosis

    International Nuclear Information System (INIS)

    Song, Jie Young; Lim, Hee Soon; Kim, Hyung Doo; Shim, Ji Young; Han, Young Soo; Son, Hyeog Jin Son; Yun, Yeon Sook

    2005-01-01

    Pulmonary fibrosis is perhaps the most universal late effect of organ damage after both chemical insult and irradiation in the treatment of lung cancer. The use chemotherapy and radiation therapy, alone or combined, can be associated with clinically significant pulmonary toxicity, which leads to pneumonia and pulmonary fibrosis. It is also reported that about 100,000 people in the United States are suffered from pulmonary fibrosis. Therefore, pulmonary fibrosis will be more focused by medicinal researchers. Because current therapies, aimed at inhibiting pulmonary inflammation that often precedes fibrosis, are effective only in a minority of suffered patients, novel therapeutic methods are highly needed. Some researchers have used bleomycininduced pulmonary fibrosis as a basis for looking at the molecular mechanisms of fibrosis, and total gene expression was monitored using genomics method. However, radiation-induced pulmonary fibrosis has not been fully focused and investigated. Here, we have analyzed changes in gene expression in response to γ- irradiation by using proteomic analysis

  14. Cystic Fibrosis-Related Diabetes (CFRD): Daily Management

    Science.gov (United States)

    Cystic Fibrosis-Related Diabetes (CFRD): Daily Management September 20, 2011 This Web cast is supported by an unrestricted ... Moran, MD Professor, Pediatric Endocrinology University of Minnesota Cystic Fibrosis-Related Diabetes (CFRD): Daily Management September 20, 2011 ...

  15. Gastroenterological endpoints in drug trials for cystic fibrosis

    NARCIS (Netherlands)

    Bodewes, Frank A. J. A.; Verkade, Henkjan J.; Wilschanski, Micheal

    2016-01-01

    The phenotype of cystic fibrosis includes a wide variety of clinical and biochemical gastrointestinal presentations. These gastrointestinal characteristics of the disease have come under renewed interest as potential outcome measures and clinical endpoints for therapeutic trials in cystic fibrosis.

  16. Ketamine induced renal fibrosis in a ketamine addition rat model

    Directory of Open Access Journals (Sweden)

    Mei-Yu Jang

    2017-09-01

    Conclusion: Ketamine treatment not only induced cystitis-like syndrome, but also renal fibrosis. These renal interstitial fibrosis changes may be induced by the TGF-β pathway. These preliminary results can provide valuable information from a clinical perspective.

  17. induced pulmonary fibrosis in mice via regulation of IL

    African Journals Online (AJOL)

    TRAF6, IL-33 and ST2 in lung tissue were determined by western blotting assay. Serum levels of ..... facilitate excessive tissue repair and fibrosis [20]. Therefore ... to cancer biology. ... liver regeneration, fibrosis and carcinogenesis. Hepatol.

  18. Fibrosis miocárdica

    Directory of Open Access Journals (Sweden)

    Adolfo Francisco de

    1959-09-01

    Full Text Available Se hace una revisión de la fibroelastosis endocárdica anotando la confusión en la denominación que existe actualmente. Se enumeran los diferentes factores que hasta ahora se han encontrado como causantes del cuadro y las distintas teorías que tratan de explicar su patogenia. Se hace la descripción del cuadro clínico y se presenta un caso de un hombre de treinta años que ingresó al Hospital de San Juan de' Dios por una afasia principalmente de expresión y un cuadro clínico de insuficiencia cardíaca de origen obscuro. Se sospechó el diagnóstico de Fibrosis miocárdica por la clínica, el  E. C. G. y los rayos X. Posteriormente estuvieron de acuerdo con este diagnóstico los datos hemodinámicos y e! hecho de que durante la 'toma de una biopsia de pulmón se produjera paro cardíaco, que hizo necesario el masaje cardíaco, encontrando un corazón enormemente aumentado de tamaño, que presentaba una placa de color blanco de 11/2 centímetros localizada sobre e! epicardio de! Ventrículo izquierdo. Al examen microscópico se observó que esta placa estaba formada por tejido conjuntivo fibroso laxo. Se discute el diagnóstico y se pone de presente que el paciente de que se trata está vivo.

  19. Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFβ signaling

    Energy Technology Data Exchange (ETDEWEB)

    Qin, Tian [School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009 (China); Yin, Shasha; Yang, Jun; Zhang, Qin; Liu, Yangyang [Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing 210093 (China); Huang, Fengjie, E-mail: hfj@cpu.edu.cn [School of Life Science & Technology, China Pharmaceutical University, Nanjing 210009 (China); Cao, Wangsen, E-mail: wangsencao@nju.edu.cn [Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing 210093 (China)

    2016-08-01

    Renal fibrosis is the common feature of chronic kidney disease and mainly mediated by TGFβ-associated pro-fibrogenic signaling, which causes excessive extracellular matrix accumulation and successive loss of kidney functions. Sinomenine (SIN), an alkaloid derived from medicinal herb extensively used in treatment of rheumatoid arthritis and various inflammatory disorders, displays renal protective properties in experimental animals; however its pharmacological potency against renal fibrosis is not explored. In this study we report that SIN possesses strong anti-renal fibrosis functions in kidney cell and in mouse fibrotic kidney. SIN beneficially modulated the pro-fibrogenic protein expression in TGFβ-treated kidney cells and attenuated the renal fibrotic pathogenesis incurred by unilateral ureteral obstruction (UUO), which correlated with its activation of Nrf2 signaling - the key defender against oxidative stress with anti-fibrotic potentials. Further investigation on its regulation of Nrf2 downstream events revealed that SIN significantly balanced oxidative stress via improving the expression and activity of anti-oxidant and detoxifying enzymes, and interrupted the pro-fibrogenic signaling of TGFβ/Smad and Wnt/β-catenin. Even more impressively SIN achieved its anti-fibrotic activities in an Nrf2-dependent manner, suggesting that SIN regulation of Nrf2-associated anti-fibrotic activities constitutes a critical component of SIN's renoprotective functions. Collectively our studies have demonstrated a novel anti-fibrotic property of SIN and its upstream events and provided a molecular basis for SIN's potential applications in treatment of renal fibrosis-associated kidney disorders. - Highlights: • Sinomenine has strong potency of inhibiting renal fibrosis in UUO mouse kidney. • Sinomenine attenuates the expression of profibrogenic proteins. • Sinomenine balances renal fibrosis-associated oxidative stress. • Sinomenine mitigates profibrogenic

  20. Non-invasive measurement of liver and pancreas fibrosis in patients with cystic fibrosis.

    Science.gov (United States)

    Friedrich-Rust, Mireen; Schlueter, Nina; Smaczny, Christina; Eickmeier, Olaf; Rosewich, Martin; Feifel, Kirstin; Herrmann, Eva; Poynard, Thierry; Gleiber, Wolfgang; Lais, Christoph; Zielen, Stefan; Wagner, Thomas O F; Zeuzem, Stefan; Bojunga, Joerg

    2013-09-01

    Patients with cystic fibrosis (CF) have a relevant morbidity and mortality caused by CF-related liver-disease. While transient elastography (TE) is an established elastography method in hepatology centers, Acoustic-Radiation-Force-Impulse (ARFI)-Imaging is a novel ultrasound-based elastography method which is integrated in a conventional ultrasound-system. The aim of the present study was to evaluate the prevalence of liver-fibrosis in patients with CF using TE, ARFI-imaging and fibrosis blood tests. 106 patients with CF were prospectively included in the present study and received ARFI-imaging of the left and right liver-lobe, ARFI of the pancreas TE of the liver and laboratory evaluation. The prevalence of liver-fibrosis according to recently published best practice guidelines for CFLD was 22.6%. Prevalence of significant liver-fibrosis assessed by TE, ARFI-right-liver-lobe, ARFI-left-liver-lobe, Fibrotest, Fibrotest-corrected-by-haptoglobin was 17%, 24%, 40%, 7%, and 16%, respectively. The best agreement was found for TE, ARFI-right-liver-lobe and Fibrotest-corrected-by-haptoglobin. Patients with pancreatic-insufficiency had significantly lower pancreas-ARFI-values as compared to patients without. ARFI-imaging and TE seem to be promising non-invasive methods for detection of liver-fibrosis in patients with CF. Copyright © 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

  1. Clinical application of noninvasive diagnosis of liver fibrosis

    OpenAIRE

    ZHU Chuanlong

    2015-01-01

    Hepatic fibrosis is the common outcome of chronic liver diseases of various causes. At present, liver biopsy is the “gold standard” for the diagnosis of liver fibrosis, but it has limitations and is invasive, which leads to the development of noninvasive assessment of liver fibrosis. The article mainly introduces the technology and application of noninvasive diagnosis of liver fibrosis from the aspects of clinical manifestation, serology, and radiology. It has pointed out the clinical value o...

  2. Noninvasive diagnosis of hepatic fibrosis in chronic hepatitis C

    OpenAIRE

    Stauber, Rudolf E; Lackner, Carolin

    2007-01-01

    Assessment of hepatic fibrosis is important for determining prognosis, guiding management decisions, and monitoring disease. Histological evaluation of liver biopsy specimens is currently considered the reference test for staging hepatic fibrosis. Since liver biopsy carries a small but significant risk, noninvasive tests to assess hepatic fibrosis are desirable. This editorial gives an overview on noninvasive methods currently available to determine hepatic fibrosis and their diagnostic accur...

  3. "Tipping" extracellular matrix remodeling towards regression of liver fibrosis

    DEFF Research Database (Denmark)

    Magdaleno, Fernando; Schierwagen, Robert; Uschner, Frank E

    2018-01-01

    Fibrosis development was initially conceived as an incessant progressive condition. Nowadays, it has become evident that fibrotic tissue undergoes a continuous two-way process: fibrogenesis and fibrinolysis, characterizing the remodeling of extracellular matrix (ECM). However, in established...... fibrosis, this two-way process is tipped towards fibrogenesis and this leads to a self-perpetuating accumulation of ECM, a distinct metabolic unit, together with other cells and processes promoting fibrosis deposition. Several mechanisms promote fibrosis regression, such as degradation of ECM, infiltration...

  4. Motivación laboral y trabajo cooperativo en el desempeño docente en los IEST públicos de Comas y Los Olivos - 2015

    OpenAIRE

    Shardín Flores, Linda

    2016-01-01

    La investigación titulada Motivación laboral y trabajo cooperativo en el desempeño docente en los IEST públicos de Comas y Los Olivos – 2015, se desarrolló a fin de alcanzar el objetivo de determinar la influencia de la motivación laboral y el trabajo cooperativo en el desempeño docente, estudio realizado en el contexto de la exigencia de la calidad educativa que afectan en la formación de las personas. Es un estudio sustantivo, descriptivo, de diseño no experimental, transvers...

  5. Matrix Remodeling in Pulmonary Fibrosis and Emphysema

    Science.gov (United States)

    O’Reilly, Philip; Antony, Veena B.; Gaggar, Amit

    2016-01-01

    Pulmonary fibrosis and emphysema are chronic lung diseases characterized by a progressive decline in lung function, resulting in significant morbidity and mortality. A hallmark of these diseases is recurrent or persistent alveolar epithelial injury, typically caused by common environmental exposures such as cigarette smoke. We propose that critical determinants of the outcome of the injury-repair processes that result in fibrosis versus emphysema are mesenchymal cell fate and associated extracellular matrix dynamics. In this review, we explore the concept that regulation of mesenchymal cells under the influence of soluble factors, in particular transforming growth factor-β1, and the extracellular matrix determine the divergent tissue remodeling responses seen in pulmonary fibrosis and emphysema. PMID:26741177

  6. Fibrocytes in pulmonary fibrosis: a brief synopsis

    Directory of Open Access Journals (Sweden)

    Shyam Maharaj

    2013-12-01

    Full Text Available Fibrocytes are bone marrow-derived, circulating mesenchymal progenitor cells that play a role in several fibrotic disorders, including lung fibrosis. They are attracted to injured tissue by various chemokines. It is likely that fibrocytes play a detrimental role in tissue homeostasis and promote fibrosis, although this paradigm needs further confirmation. This would make fibrocytes a possible novel treatment target for fibrotic disorders. Fibrocytes also have some potential as a biomarker for idiopathic pulmonary fibrosis (IPF and other diseases, but the promising preliminary data from single centre studies still require independent validation. Despite several, as yet, unresolved issues, it has become clear that fibrocytes are more than an incidental finding in lung injury and repair, and may hold great promise for the future of IPF management.

  7. Effect of Green Tea Extract Encapsulated Into Chitosan Nanoparticles on Hepatic Fibrosis Collagen Fibers Assessed by Atomic Force Microscopy in Rat Hepatic Fibrosis Model.

    Science.gov (United States)

    Safer, Abdel-Majeed A; Hanafy, Nomany A; Bharali, Dhruba J; Cui, Huadong; Mousa, Shaker A

    2015-09-01

    The present study examined the effect of Green Tea Extract (GTE) encapsulated into Chitosan Nanoparticles (CS-NPs) on hepatic fibrosis in rat model as determined by atomic force microscopy (AFM). The bioactive compounds in GTE encapsulated into CS-NPs were determined using LC-MS/MS method. Additionally, the uptake of GTE-CS NPs in HepG2 cells showed enhanced uptake. In experimental fibrosis model, AFM was used as a high resolution microscopic tool to investigate collagen fibers as an indicator of hepatic fibrosis induced by treatment with CCl4. Paraffin sections of fibrotic liver tissues caused by CC4 treatment of rats and the effect of GTE-CS NPs treatment with or without CCl4 on hepatic fibrosis were examined. Liver tissues from the different groups of animals were de-waxed and processed as for normal H/E staining and Masson's trichrome staining to locate the proper area of ECM collagen in the CCl4 group versus collagen in liver tissues treated with the GTE-CS NPs with or without CCl4. Selected areas of paraffin sections were trimmed off and fixed flat on top of mica and inserted in the AFM stage. H/E staining, Masson's trichrome stained slides, and AFM images revealed that collagen fibers of 250 to 300 nm widths were abundant in the fibrotic liver samples while those of GTE-CS NPs were clear as in the control group. Data confirmed the hypothesis that GTE-CS NPs are effective in removing all the extracellular collagen caused by CCl4 in the hepatic fibrosis rat liver.

  8. Endocytosis and intracellular protein degradation in cystic fibrosis fibroblasts

    International Nuclear Information System (INIS)

    Jessup, W.; Dean, R.T.

    1983-01-01

    Normal rates of pinocytosis of [ 3 H]sucrose were measured in cystic fibrosis fibroblasts, and were not affected by the addition of cystic fibrosis serum. Bulk protein degradation (a significant proportion of which occurs intralysosomally following autophagy) and its regulation by growth state were apparently identical in normal and cystic fibrosis cultures. (Auth.)

  9. Living with Cystic Fibrosis: A Guide for the Young Adult.

    Science.gov (United States)

    Cystic Fibrosis Foundation, Atlanta, GA.

    Intended for the young adult with cystic fibrosis, the booklet provides information on dealing with problems and on advances in treatment and detection related to the disease. Addressed are the following topics: description of cystic fibrosis; inheritance of cystic fibrosis; early diagnosis; friends, careers, and other matters; treatment;…

  10. [Endomyocardial fibrosis with massive calcification of the left ventricle].

    Science.gov (United States)

    Trigo, Joana; Camacho, Ana; Gago, Paula; Candeias, Rui; Santos, Walter; Marques, Nuno; Matos, Pedro; Brandão, Victor; Gomes, Veloso

    2010-03-01

    Endomyocardial fibrosis is a rare disease, endemic in tropical countries. It is characterized by fibrosis of the endocardium that can extend to myocardium. Important calcification of the endocardium is rare with only a few cases reported in the literature. We report a case of endomyocardial fibrosis in a european caucasian patient, associated with massive calcification of left ventricle.

  11. Appetite stimulants for people with cystic fibrosis.

    Science.gov (United States)

    Chinuck, Ruth; Dewar, Jane; Baldwin, David R; Hendron, Elizabeth

    2014-07-27

    Chronic loss of appetite in cystic fibrosis concerns both individuals and families. Appetite stimulants have been used to help cystic fibrosis patients with chronic anorexia attain optimal body mass index and nutritional status. However, these may have adverse effects on clinical status. The aim of this review is to systematically search for and evaluate evidence on the beneficial effects of appetite stimulants in the management of CF-related anorexia and synthesize reports of any side-effects. Trials were identified by searching the Cochrane Cystic Fibrosis and Genetic Disorders Group's Cystic Fibrosis Trials Register, MEDLINE, Embase, CINAHL, handsearching reference lists and contacting local and international experts.Last search of online databases: 01 April 2014.Last search of the Cystic Fibrosis Trials Register: 08 April 2014. Randomised and quasi-randomised controlled trials of appetite stimulants, compared to placebo or no treatment for at least one month in adults and children with cystic fibrosis. Authors independently extracted data and assessed the risk of bias within eligible trials. Meta-analyses were performed. Three trials (total of 47 recruited patients) comparing appetite stimulants (cyproheptadine hydrochloride and megesterol acetate) to placebo were included; the numbers of adults or children within each trial were not always reported. The risk of bias of the included trials was graded as moderate.A meta-analysis of all three trials showed appetite stimulants produced a larger increase in weight z score at three months compared to placebo, mean difference 0.61 (95% confidence interval 0.29 to 0.93) (P children, appetite stimulants improved only two of the outcomes in this review - weight (or weight z score) and appetite; and side effects were insufficiently reported to determine the full extent of their impact. Whilst the data may suggest the potential use of appetite stimulants in treating anorexia in adults and children with cystic fibrosis

  12. Idiopathic Pulmonary Fibrosis: Diagnosis and Clinical Manifestations

    Science.gov (United States)

    Nakamura, Yutaro; Suda, Takafumi

    2015-01-01

    Idiopathic pulmonary fibrosis (IPF) is a parenchymal lung disease characterized by progressive interstitial fibrosis. The clinical course of IPF can be unpredictable and may be punctuated by acute exacerbations. Although much progress is being made in unraveling the mechanisms underlying IPF, effective therapy for improving survival remains elusive. Longitudinal disease profiling, especially in terms of clinical manifestations in a large cohort of patients, should lead to proper management of the patients and development of new treatments for IPF. Appropriate multidisciplinary assessment in ongoing registries is required to achieve this. This review summarizes the current status of the diagnosis and clinical manifestations of IPF. PMID:27625576

  13. The Role of PPARs in Lung Fibrosis

    Directory of Open Access Journals (Sweden)

    Heather F. Lakatos

    2007-01-01

    wound healing. PPARβ/δ agonists inhibit lung fibroblast proliferation and enhance the antifibrotic properties of PPARγ agonists. PPARγ ligands oppose the profibrotic effect of TGF-β, which induces differentiation of fibroblasts to myofibroblasts, a critical effector cell in fibrosis. PPARγ ligands, including the thiazolidinedione class of antidiabetic drugs, effectively inhibit lung fibrosis in vitro and in animal models. The clinical availability of potent and selective PPARα and PPARγ agonists should facilitate rapid development of successful treatment strategies based on current and ongoing research.

  14. Resiliencia: Contexto no clínico para trabajo social

    Directory of Open Access Journals (Sweden)

    Ángela María Quintero Velásquez

    2005-05-01

    Full Text Available Resiliencia es un término nuevo, mas no el fenómeno que representa. El concepto que surge a mediados del siglo pasado, se adopta de las ciencias naturales (física y osteología, y ya está incluido en el campo social.La Resiliencia ofrece alternativas a todos los profesionales, pero todavía no es un concepto homogéneo. La Resiliencia es un cambio de paradigma: privilegia el enfoque en las fortalezas, no en el déficit o problema. Involucra a los individuos, familias, grupos, comunidades e instituciones a que sean parte de la solución con el conjunto de recursos internos y externos que permitan enfrentar situaciones críticas de todo tipo. Se supera la noción de Resiliencia individual y se conceptualiza en América latina sobre la resiliencia familiar o relacional, comunitaria, andina y empresarial.La Resiliencia familiar implica: vínculo emocional significativo, conductas éticas, soporte espiritual y contexto ecológico. Los factores resilientes de la familia son la cohesión, la comunicación, la adaptación, la afectividad.Para el Trabajo Social contemporáneo y otras profesiones del desarrollo humano, el construccionismo sustenta el principio de fortalecer la habilidad de las personas para sobrellevar las tareas y los problemas que enfrentan en la vida. Los profesionales de estas áreas, están preparados para actuar en Contextos no Clínicos de atención sociofamiliar: recepción-orientación, evaluación, prevención, promoción, educación. Asumen la resiliencia como enfoque y estrategia metodológica.La producción teórica sobresaliente de Resiliencia en Trabajo Social está en Colombia (Universidad de Antioquia, Costa Rica y España, pero es utilizada en gran variedad de proyectos de desarrollo humano.

  15. Resiliencia: Contexto no clínico para trabajo social

    Directory of Open Access Journals (Sweden)

    Ángela María Quintero Velásquez

    2005-01-01

    Full Text Available Resiliencia es un término nuevo, mas no el fenómeno que representa. El concepto que surge a mediados del siglo pasado, se adopta de las ciencias naturales (física y osteología, y ya está incluido en el campo social. La Resiliencia ofrece alternativas a todos los profesionales, pero todavía no es un concepto homogéneo. La Resiliencia es un cambio de paradigma: privilegia el enfoque en las fortalezas, no en el déficit o problema. Involucra a los individuos, familias, grupos, comunidades e instituciones a que sean parte de la solución con el conjunto de recursos internos y externos que permitan enfrentar situaciones críticas de todo tipo. Se supera la noción de Resiliencia individual y se conceptualiza en América latina sobre la resiliencia familiar o relacional, comunitaria, andina y empresarial. La Resiliencia familiar implica: vínculo emocional significativo, conductas éticas, soporte espiritual y contexto ecológico. Los factores resilientes de la familia son la cohesión, la comunicación, la adaptación, la afectividad. Para el Trabajo Social contemporáneo y otras profesiones del desarrollo humano, el construccionismo sustenta el principio de fortalecer la habilidad de las personas para sobrellevar las tareas y los problemas que enfrentan en la vida. Los profesionales de estas áreas, están preparados para actuar en Contextos no Clínicos de atención sociofamiliar: recepción-orientación, evaluación, prevención, promoción, educación. Asumen la resiliencia como enfoque y estrategia metodológica. La producción teórica sobresaliente de Resiliencia en Trabajo Social está en Colombia (Universidad de Antioquia, Costa Rica y España, pero es utilizada en gran variedad de proyectos de desarrollo humano

  16. Epithelial to mesenchymal transition-related proteins ZEB1, β-catenin, and β-tubulin-III in idiopathic pulmonary fibrosis.

    Science.gov (United States)

    Chilosi, Marco; Caliò, Anna; Rossi, Andrea; Gilioli, Eliana; Pedica, Federica; Montagna, Licia; Pedron, Serena; Confalonieri, Marco; Doglioni, Claudio; Ziesche, Rolf; Grubinger, Markus; Mikulits, Wolfgang; Poletti, Venerino

    2017-01-01

    Epithelial to mesenchymal transition has been suggested as a relevant contributor to pulmonary fibrosis, but how and where this complex process is triggered in idiopathic pulmonary fibrosis is not fully understood. Beta-tubulin-III (Tubβ3), ZEB1, and β-catenin are partially under the negative control of miR-200, a family of micro-RNAs playing a major role in epithelial to mesenchymal transition, that are reduced in experimental lung fibrosis and idiopathic pulmonary fibrosis. We wonder whether in situ expression of these proteins is increased in idiopathic pulmonary fibrosis, to better understand the significance of miR-200 feedback loop and epithelial to mesenchymal transition. We investigated the immunohistochemical and immunofluorescent expression and precise location of ZEB1, Tubβ3, and β-catenin in tissue samples from 34 idiopathic pulmonary fibrosis cases and 21 controls (5 normal lungs and 16 other interstitial lung diseases). In 100% idiopathic pulmonary fibrosis samples, the three proteins were concurrently expressed in fibroblastic foci, as well in damaged epithelial cells overlying these lesions and in pericytes within neo-angiogenesis areas. These results were also confirmed by immunofluorescence assay. In controls the abnormal expression of the three proteins was absent or limited. This is the first study that relates concurrent expression of Tubβ3, ZEB1, and β-catenin to abnormal epithelial and myofibroblast differentiation in idiopathic pulmonary fibrosis, providing indirect but robust evidence of miR-200 deregulation and epithelial to mesenchymal transition activation in idiopathic pulmonary fibrosis. The abnormal expression and localization of these proteins in bronchiolar fibro-proliferative lesions are unique for idiopathic pulmonary fibrosis, and might represent a disease-specific marker in challenging lung biopsies.

  17. WE-FG-206-12: Enhanced Laws Textures: A Potential MRI Surrogate Marker of Hepatic Fibrosis in a Murine Model

    International Nuclear Information System (INIS)

    Li, B; Yu, H; Jara, H; Soto, J; Anderson, S

    2016-01-01

    Purpose: To compare enhanced Laws texture derived from parametric proton density (PD) maps to other MRI-based surrogate markers (T2, PD, ADC) in assessing degrees of liver fibrosis in a murine model of hepatic fibrosis using 11.7T scanner. Methods: This animal study was IACUC approved. Fourteen mice were divided into control (n=1) and experimental (n=13). The latter were fed a DDC-supplemented diet to induce hepatic fibrosis. Liver specimens were imaged using an 11.7T scanner; the parametric PD, T2, and ADC maps were generated from spin-echo pulsed field gradient and multi-echo spin-echo acquisitions. Enhanced Laws texture analysis was applied to the PD maps: first, hepatic blood vessels and liver margins were segmented/removed using an automated dual-clustering algorithm; secondly, an optimal thresholding algorithm was applied to reduce the partial volume artifact; next, mean and stdev were corrected to minimize grayscale variation across images; finally, Laws texture was extracted. Degrees of fibrosis was assessed by an experienced pathologist and digital image analysis (%Area Fibrosis). Scatterplots comparing enhanced Laws texture, T2, PD, and ADC values to degrees of fibrosis were generated and correlation coefficients were calculated. Unenhanced Laws texture was also compared to assess the effectiveness of the proposed enhancements. Results: Hepatic fibrosis and the enhanced Laws texture were strongly correlated with higher %Area Fibrosis associated with higher Laws texture (r=0.89). Only a moderate correlation was detected between %Area Fibrosis and unenhanced Laws texture (r=0.70). Strong correlation also existed between ADC and %Area Fibrosis (r=0.86). Moderate correlations were seen between %Area Fibrosis and PD (r=0.65) and T2 (r=0.66). Conclusions: Higher degrees of hepatic fibrosis are associated with increased Laws texture. The proposed enhancements improve the accuracy of Laws texture. Enhanced Laws texture features are more accurate than PD and T2 in

  18. WE-FG-206-12: Enhanced Laws Textures: A Potential MRI Surrogate Marker of Hepatic Fibrosis in a Murine Model

    Energy Technology Data Exchange (ETDEWEB)

    Li, B; Yu, H; Jara, H; Soto, J; Anderson, S [Boston University Medical Center, Boston, MA (United States)

    2016-06-15

    Purpose: To compare enhanced Laws texture derived from parametric proton density (PD) maps to other MRI-based surrogate markers (T2, PD, ADC) in assessing degrees of liver fibrosis in a murine model of hepatic fibrosis using 11.7T scanner. Methods: This animal study was IACUC approved. Fourteen mice were divided into control (n=1) and experimental (n=13). The latter were fed a DDC-supplemented diet to induce hepatic fibrosis. Liver specimens were imaged using an 11.7T scanner; the parametric PD, T2, and ADC maps were generated from spin-echo pulsed field gradient and multi-echo spin-echo acquisitions. Enhanced Laws texture analysis was applied to the PD maps: first, hepatic blood vessels and liver margins were segmented/removed using an automated dual-clustering algorithm; secondly, an optimal thresholding algorithm was applied to reduce the partial volume artifact; next, mean and stdev were corrected to minimize grayscale variation across images; finally, Laws texture was extracted. Degrees of fibrosis was assessed by an experienced pathologist and digital image analysis (%Area Fibrosis). Scatterplots comparing enhanced Laws texture, T2, PD, and ADC values to degrees of fibrosis were generated and correlation coefficients were calculated. Unenhanced Laws texture was also compared to assess the effectiveness of the proposed enhancements. Results: Hepatic fibrosis and the enhanced Laws texture were strongly correlated with higher %Area Fibrosis associated with higher Laws texture (r=0.89). Only a moderate correlation was detected between %Area Fibrosis and unenhanced Laws texture (r=0.70). Strong correlation also existed between ADC and %Area Fibrosis (r=0.86). Moderate correlations were seen between %Area Fibrosis and PD (r=0.65) and T2 (r=0.66). Conclusions: Higher degrees of hepatic fibrosis are associated with increased Laws texture. The proposed enhancements improve the accuracy of Laws texture. Enhanced Laws texture features are more accurate than PD and T2 in

  19. Non-Invasive Evaluation of Cystic Fibrosis Related Liver Disease in Adults with ARFI, Transient Elastography and Different Fibrosis Scores

    OpenAIRE

    Karlas, Thomas; Neuschulz, Marie; Oltmanns, Annett; Güttler, Andrea; Petroff, David; Wirtz, Hubert; Mainz, Jochen G.; Mössner, Joachim; Berg, Thomas; Tröltzsch, Michael; Keim, Volker; Wiegand, Johannes

    2012-01-01

    BACKGROUND: Cystic fibrosis-related liver disease (CFLD) is present in up to 30% of cystic fibrosis patients and can result in progressive liver failure. Diagnosis of CFLD is challenging. Non-invasive methods for staging of liver fibrosis display an interesting diagnostic approach for CFLD detection. AIM: We evaluated transient elastography (TE), acoustic radiation force impulse imaging (ARFI), and fibrosis indices for CFLD detection. METHODS: TE and ARFI were performed in 55 adult CF patient...

  20. Psychological interventions for cystic fibrosis.

    Science.gov (United States)

    Glasscoe, C A; Quittner, A L

    2003-01-01

    As survival estimates for cystic fibrosis (CF) steadily increase long-term management has become an important focus for intervention. Psychological interventions are largely concerned with emotional and social adjustments, adherence to treatment and quality of life, however no systematic review of such interventions has been undertaken for this disease. To describe the extent and quality of effectiveness studies utilising psychological interventions for CF and whether these interventions provide significant psychosocial and physical benefits in addition to standard care. Relevant trials were identified from searches of Ovid MEDLINE, the Cochrane trial registers for CF and Depression, Anxiety and Neurosis Groups and PsychINFO; unpublished trials were located through professional networks and Listserves. Most recent search: April 2003. This review included RCTs and quasi-randomised trials. Study participants were children and adults diagnosed with CF, and their immediate family members. Psychological interventions were from a broad range of modalities and outcomes were primarily psychosocial, although physical outcomes and cost effectiveness were also considered. Two reviewers independently selected relevant trials and assessed their methodological quality. For binary and continuous outcomes a pooled estimate of treatment effect was calculated for each outcome. This review is based on the findings of eight studies, representing data from a total of 358 participants. Studies fell into four conceptually similar groups: (1) gene pre-test education counselling for relatives of those with CF (one study); (2) biofeedback, massage and music therapy to assist physiotherapy (three studies); (3) behavioural intervention to improve dietary intake in children up to 12 years (three studies); and (4) self-administration of treatments to improve quality of life in adults (one study). Interventions were largely educational or behavioural, targeted at specific treatment concerns

  1. Talento humano y trabajo en equipo del personal directivo de las universidades del municipio Maracaibo

    Directory of Open Access Journals (Sweden)

    Maribel Medina Fuenmayor

    2010-01-01

    Full Text Available El propósito de esta investigación fue determinar la relación entre talento humano y trabajo en equipo del personal directivo de las universidades del Municipio Maracaibo, sobre la base de los enfoques teóricos de Alles (2005, Dolan et al. (2003, Gubman (2000, Hayes (2002, Jericó (2001, entre otros. La investigación se tipificó como correlacional, no experimental y transversal, utilizando una población de 31 sujetos pertenecientes a la planta directiva de administración de las referidas universidades públicas y privadas. La técnica de recolección de datos fue la observación mediante encuesta, para lo cual se diseñaron dos (2 instrumentos de recolección de datos, estructurados con cinco alternativas de respuestas bajo una escala de actitud tipo Likert, utilizando una validez de contenido por el criterio de 10 expertos, utilizando además el análisis discriminante de ítems, lo cual permitió mayor certeza en sus diseños. La confiabilidad fue calculada por el coeficiente Alfa de Cronbach, el cual arrojó un valor de 0.99 para talento humano y 0.91 para trabajo en equipo, siendo altamente consistentes. Los resultados se analizaron mediante estadística descriptiva con frecuencias absolutas y porcentuales, soportadas con medidas de tendencia central, haciendo uso además de la estadística inferencial con pruebas no paramétricas. Como conclusión, se observó una correlación con dirección positiva y magnitud fuerte entre las variables con un índice rho de Spearman de 0.88, lo que sugiere que bajo las actuales condiciones de este estudio existe una fuerte concomitancia entre las variables.

  2. Estado del arte de la seguridad y salud en el trabajo en el plan nacional de seguridad y salud en el trabajo Colombia: 2013-2017

    OpenAIRE

    Aguillón Ramírez, Mariana C.

    2014-01-01

    El presente estudio corresponde al estado del arte del Plan Nacional de Seguridad y Salud en el Trabajo Colombia 2013 – 2017 y la incorporación a este, de los principios de seguridad y salud en el trabajo promulgados por la OIT en 2008, y el marco epistémico de la seguridad y salud en el trabajo de la Universidad Nacional de Colombia. A partir de la revisión detallada de los documentos anteriormente mencionados, se prosiguió con la lectura crítica del Plan Nacional de Seguridad y Salud en el ...

  3. Perspectiva societario-económica del trabajo: la evolución del mundo del trabajo y su dimensión ético-empresarial

    OpenAIRE

    García Echevarría, Santiago

    2015-01-01

    La preocupación del desarrollo del "trabajo" no solo se debe al enorme peso societario y humano del desempleo en muchos Países y tampoco lo es solo por las crecientes exigencias que imponen la tecnología y la globalización, sino que su creación y desarrollo se centra hoy más en el desarrollo de la Persona que en los aspectos concernientes al "puesto de trabajo". En primer término el "trabajo" es vital para el desarrollo integral de la Persona, es su dimensión ética, pero es, al propio tiempo,...

  4. Arte participativo. El trabajo como (auto representación

    Directory of Open Access Journals (Sweden)

    Ana Amado

    2010-12-01

    Full Text Available El “giro social” contemporáneo del documentalismo audiovisual y de las performances teatrales, plantea una serie de cuestiones éticas y también estéticas alrededor de las formas artísticas vueltas a la representación del padecimiento de los pueblos. Con diferentes variantes, se tiende a conceder a las identidades subalternas el centro de la escena, o de un espacio de exhibición determinado, donde explican o desempeñan acciones de acuerdo a sus respectivas experiencias, sean estas de clase, de género, de edad, sexualidad, pero que en la última década están cada vez más concentradas en el mundo del trabajo o en las consecuencias de su crisis. Los apuntes que siguen abordan esta cuestión y sus paradojas a través de la revisión de algunas experiencias argentinas recientes, entre ellas la película Estrellas, de Federico León y las intervenciones teatrales “Mucamas de hotel” de Lola Arias y “Fábrica”, de Gerardo Neuman.

  5. para la investigación en trabajo social

    Directory of Open Access Journals (Sweden)

    Martín Goyette

    2005-01-01

    Full Text Available El presente artículo trata sobre cómo la integración de las personas y de los grupos sociales a la sociedad, especialmente de poblaciones vulnerables, ha sido siempre objeto central del servicio social en Quebec. Desde mediados de los años setenta, la inserción, junto a su misión de adaptación y control social, ha captado mucho más la atención del trabajo social luego de importantes cambios sociales (Goyette, 2004. Así, poblaciones que no acostumbraban a recurrir a programas de servicio social ni al Estado, –mujeres y personas en general, pero sobre todo los jóvenes- van desde entonces a ocupar el centro de interés del servicio social y de las políticas públicas. Frente a esto, el servicio social llevará su preocupación al tema de la inserción de la juventud, en la medida en que el aumento de figuras de exclusión refuerza la necesidad de favorecer los valores de solidaridad, justicia social, respeto y autonomía, bandera de esta disciplina tanto en su ética como en su práctica.

  6. Letalidad por accidentes de trabajo en Villa Clara

    Directory of Open Access Journals (Sweden)

    Miguel Gómez Vital

    1999-01-01

    Full Text Available Se valora la problemática de la letalidad por accidentes laborales en la provincia de Villa Clara, en el período comprendido entre 1987 y 1997. Se determinan las principales causas, y fue la conducta negligente del individuo la que más incidió. En los últimos años de la década del 80 se registraron más cantidad de muertes por accidentes de trabajo, los que ocurrieron fundamentalmente en el puesto laboral. Queda puntualizado el importante rol del equipo médico en instituciones laborales.The problem of letality from working accidents in the province of Villa Clara from 1987 to 1997 was evaluated. The main causes were also determined. Individual negligent behaviour proved to be the first cause. More deaths from working accidents were registered late in the 1980s. Most of these accidents occurred at the working place. It was stressed the important role played by the medical team at the working institutions

  7. Roles parentales y el trabajo fuera del hogar

    Directory of Open Access Journals (Sweden)

    María Amarís Macías

    2004-01-01

    Full Text Available Este trabajo presenta un análisis de los resultados de investigaciones acerca de los roles de padre y de madre en la familia. Se comparan e integran procesos de investigación que se han llevado a cabo con familias de Barranquilla. El análisis pretende trascender la realidad del ser humano en la familia que diariamente enfrenta situaciones sociales que determinan la configuración de sus roles. Para contextualizar el tema de los roles se hace mención especial a la familia como uno de los principales contextos para la introyección y el ejercicio de los roles posibles que la sociedad da como opción a la persona. Se señalan, además de las características centrales de los roles de padre y de madre en el ámbito familiar, los conflictos y tensiones que éstos experimentan al vivir sus respectivos roles en correspondencia con las demandas de los roles laborales y sociales.

  8. micropolítica del trabajo en salud

    Directory of Open Access Journals (Sweden)

    Emerson Elias Merhy

    2006-01-01

    Full Text Available El artículo presenta las bases conceptuales de la política de educación en salud desarrollada por el Ministerio de Salud en Brasil entre enero de 2003 y julio de 2005; rescatando sintéticamente la historia de la construcción del Sistema Único de Salud (el sistema nacional de salud en Brasil y de los principales retos para su consolidación, entre ellos los cambios en las maneras de producir las políticas y las prácticas de salud. Se presenta además un debate sobre la construcción del concepto de Educación Permanente en Salud y una discusión sobre la naturaleza del trabajo en salud y su composición tecnológica, así como de la dinámica institucional de su constitución, trayendo el plan de la micropolítica como elemento fundamental para la comprensión y transformación de las prácticas de salud.

  9. The vitamin E reduces liver lipoperoxidation and fibrosis in a model of nonalcoholic steatohepatitis A vitamina E reduz a lipoperoxidação hepática e a fibrose em modelo experimental de esteatohepatite não-alcoólica

    Directory of Open Access Journals (Sweden)

    Idilio Zamin Jr

    2010-03-01

    Full Text Available CONTEXT: No effective treatment is available for nonalcoholic steatohepatitis in nowadays. OBJECTIVES: To develop a model of nonalcoholic steatohepatitis induced by a methionine and choline deficient diet, as well as to evaluate the role of metformin, vitamin E and simvastatin in the nonalcoholic steatohepatitis progression. METHODS: The study analyzed prospectively 50 Wistar rats for a 90-day period and divided them into five groups of 10 rats. One group was given standard rat diet and the others received the methionine and choline deficient diet. Among the four groups that received this diet, one received saline 0,9% and the others received metformin, vitamin E or simvastatin. After the study period, the animals were sacrificed and their blood was collected for biochemical analysis. The livers were removed for lipoperoxidation analysis and for the histological examinations. RESULTS: The methionine and choline deficient diet was able to induce steatosis in 100% of the animals and nonalcoholic steatohepatitis in 27 (69.2%. The alanine aminotransferase levels were significantly higher in the simvastatin group. The aspartate aminotransferase levels were also higher in the simvastatin group, but were statistically significant only in relation to the standard diet group. When lipoperoxidation values were compared, the groups that received standard rat diet and methionine and choline deficient with vitamin E presented significantly lower rates than the others. The presence of fibrosis was significantly smaller in the group receiving vitamin E. CONCLUSIONS: The diet used was able to induce steatosis and nonalcoholic steatohepatitis. Besides vitamin E showed to reduce the liver oxidative stress, as well as the fibrosis developmentCONTEXTO: Ainda não há um tratamento comprovadamente eficaz para a esteatohepatite não-alcoólica. OBJETIVO: Desenvolver um modelo experimental de esteatohepatite não-alcoólica induzida por dieta deficiente em metionina e

  10. Clinical application of noninvasive diagnosis of liver fibrosis

    Directory of Open Access Journals (Sweden)

    ZHU Chuanlong

    2015-03-01

    Full Text Available Hepatic fibrosis is the common outcome of chronic liver diseases of various causes. At present, liver biopsy is the “gold standard” for the diagnosis of liver fibrosis, but it has limitations and is invasive, which leads to the development of noninvasive assessment of liver fibrosis. The article mainly introduces the technology and application of noninvasive diagnosis of liver fibrosis from the aspects of clinical manifestation, serology, and radiology. It has pointed out the clinical value of these noninvasive diagnosis techniques, and it discusses the progress in clinical research and its limitations for noninvasive diagnosis of liver fibrosis.

  11. Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.

    Science.gov (United States)

    Locatelli, Luigi; Cadamuro, Massimiliano; Spirlì, Carlo; Fiorotto, Romina; Lecchi, Silvia; Morell, Carola Maria; Popov, Yury; Scirpo, Roberto; De Matteis, Maria; Amenduni, Mariangela; Pietrobattista, Andrea; Torre, Giuliano; Schuppan, Detlef; Fabris, Luca; Strazzabosco, Mario

    2016-03-01

    Congenital hepatic fibrosis (CHF) is a disease of the biliary epithelium characterized by bile duct changes resembling ductal plate malformations and by progressive peribiliary fibrosis, in the absence of overt necroinflammation. Progressive liver fibrosis leads to portal hypertension and liver failure; however, the mechanisms leading to fibrosis in CHF remain elusive. CHF is caused by mutations in PKHD1, a gene encoding for fibrocystin, a ciliary protein expressed in cholangiocytes. Using a fibrocystin-defective (Pkhd1(del4/del4)) mouse, which is orthologous of CHF, we show that Pkhd1(del4/del4) cholangiocytes are characterized by a β-catenin-dependent secretion of a range of chemokines, including chemokine (C-X-C motif) ligands 1, 10, and 12, which stimulate bone marrow-derived macrophage recruitment. We also show that Pkhd1(del4/del4) cholangiocytes, in turn, respond to proinflammatory cytokines released by macrophages by up-regulating αvβ6 integrin, an activator of latent local transforming growth factor-β1. While the macrophage infiltrate is initially dominated by the M1 phenotype, the profibrogenic M2 phenotype increases with disease progression, along with the number of portal myofibroblasts. Consistent with these findings, clodronate-induced macrophage depletion results in a significant reduction of portal fibrosis and portal hypertension as well as of liver cysts. Fibrosis can be initiated by an epithelial cell dysfunction, leading to low-grade inflammation, macrophage recruitment, and collagen deposition; these findings establish a new paradigm for biliary fibrosis and represent a model to understand the relationship between cell dysfunction, parainflammation, liver fibrosis, and macrophage polarization over time. © 2015 by the American Association for the Study of Liver Diseases.

  12. El videojuego League of legends y su efecto en memoria de trabajo visual y solución de problemas

    OpenAIRE

    Leyva-Rodríguez, Jesús Eduardo; Varela-García, Juan David

    2016-01-01

    El propósito de este estudio es medir los efectos que tiene el videojuego League of Legends en los procesos cognitivos de memoria de trabajo visual (MVT) y solución de problemas (SP). Para medir dichos efectos se implementó un diseño pre test-post con un grupo experimental y uno control, compuestos cada uno por siete participantes, en donde se evaluaron los procesos previamente mencionados utilizando los cubos de Corsi para MVT y las matrices del WAIS III para SP. Después de realizar los resp...

  13. El trabajo a turnos como factor de riesgo para lumbago en un grupo de trabajadores peruanos.

    Directory of Open Access Journals (Sweden)

    Juan Carlos Palomino Baldeon

    2005-07-01

    Full Text Available Objetivo: Identificar la asociación entre trabajo a turnos y lumbago en un grupo de trabajadores mineros. Materiales y métodos: Estudio Caso Control realizado el año 2003 en un grupo de trabajadores mineros. Se revisaron las historias electrónicas de los trabajadores con lumbago, en quienes se obtuvo la edad, sexo, estado civil, grado de instrucción, tiempo de trabajo, índice masa corporal (IMC, trabajo a turnos (8 horas y puesto de trabajo, éste último, se dividió en "white collar" (trabajo de oficina y "blue collar"(trabajo no oficina. Se calculó el Odds Ratio para trabajo a turnos y puesto de trabajo versus lumbago. Resultados: De 1 240 trabajadores, 149 (72% tuvieron lumbago sin ciática y 56 (28% con ciática. No se encontró diferencias estadísticamente significativas para las variables demográficas descritas entre los grupos de estudio. Se encontró que los trabajadores de trabajo por turnos tuvieron un OR para lumbago sin ciática de 1,28 (IC de 0,89 - 1,82 y lumbago con ciática un OR de 2,12 (CI 1,4- 3,93. En relación al puesto de trabajo tipo blue collar se encontró que para lumbago sin ciática tuvo un OR de 1,63 (IC 1,05-2,51 y para lumbago con ciática se tiene OR de 1,48 (IC 0,76-2,9. Conclusión: Existe un riesgo mayor en trabajadores de turnos de trabajo para lumbago con ciática y mayor riesgo en trabajadores con puestos de trabajo tipo blue collar para lumbago sin ciática. (Rev Med Hered 2005;16:184-189.

  14. Derechos laborales: una mirada al derecho a la calidad de vida en el trabajo

    OpenAIRE

    Patlán Pérez Juana

    2016-01-01

    Se tiene como objetivo sustentar la calidad de vida en el trabajo como un derecho humano laboral que repercute en la salud ocupacional de los trabajadores. La calidad de vida en el trabajo es un constructo multidimensional y complejo que hace referencia principalmente a la satisfacción de una amplia gama de necesidades de los individuos (reconocimiento, estabilidad laboral, equilibrio empleo-familia, motivación, seguridad, entre otros) mediante un trabajo formal ...

  15. Pulmonary fibrosis caused by histiocytosis X

    International Nuclear Information System (INIS)

    Reinbold, W.D.; Seemann, W.R.; Ruehle, K.H.

    1984-01-01

    This paper reports on a 23-year-old man suffering from pulmonary fibrosis caused by localised histiocytosis X. Although chest film examination shows diffuse pulmonary involvement the patient is asymptomatic. No other organ systems are involved. The different forms and prognosis of histiocytosis X are discussed. (orig.)

  16. MicroRNA mimicry blocks pulmonary fibrosis

    Science.gov (United States)

    Montgomery, Rusty L; Yu, Guoying; Latimer, Paul A; Stack, Christianna; Robinson, Kathryn; Dalby, Christina M; Kaminski, Naftali; van Rooij, Eva

    2014-01-01

    Over the last decade, great enthusiasm has evolved for microRNA (miRNA) therapeutics. Part of the excitement stems from the fact that a miRNA often regulates numerous related mRNAs. As such, modulation of a single miRNA allows for parallel regulation of multiple genes involved in a particular disease. While many studies have shown therapeutic efficacy using miRNA inhibitors, efforts to restore or increase the function of a miRNA have been lagging behind. The miR-29 family has gained a lot of attention for its clear function in tissue fibrosis. This fibroblast-enriched miRNA family is downregulated in fibrotic diseases which induces a coordinate increase of many extracellular matrix genes. Here, we show that intravenous injection of synthetic RNA duplexes can increase miR-29 levels in vivo for several days. Moreover, therapeutic delivery of these miR-29 mimics during bleomycin-induced pulmonary fibrosis restores endogenous miR-29 function whereby decreasing collagen expression and blocking and reversing pulmonary fibrosis. Our data support the feasibility of using miRNA mimics to therapeutically increase miRNAs and indicate miR-29 to be a potent therapeutic miRNA for treating pulmonary fibrosis. PMID:25239947

  17. Immunoreactive trypsin and neonatalscreening for cystic fibrosis

    International Nuclear Information System (INIS)

    Travert, G.; Laroche, D.; Blandin, C.; Pasquet, C.

    1988-01-01

    Immunoreactive trypsin (IRT) was measured in dried blood spots from 160.822 five-day-old babies as a part of a regionwide neonatal screening program for cystic fibrosis. A second test was performed for 492 babies in whom blood IRT levels were found greater than 900 μg/l; retesting revealed persistent elevation in 55. Sweat testing confirmed cystic fibrosis in 43 babies, but results were normal in 12. During the course of this study, a total of 51 cystic fibrosis babies were identified: 43 by newborn screening, 6 because they had meconium ileus; so, early diagnosis was achieved in 49 cases out of 51. Two newborn babies did not have elevated IRT and they were missed by the screening test. Our results confirm that elevated blood IRT is characteristic of newborn babies with cystic fibrosis and show that this test has an excellent specificity (99.7%) and a good sensitivity (95%) when used as a neonatal screening test [fr

  18. Respiratory bacterial infections in cystic fibrosis

    DEFF Research Database (Denmark)

    Ciofu, Oana; Hansen, Christine R; Høiby, Niels

    2013-01-01

    PURPOSE OF REVIEW: Bacterial respiratory infections are the main cause of morbidity and mortality in patients with cystic fibrosis (CF). Pseudomonas aeruginosa remains the main pathogen in adults, but other Gram-negative bacteria such as Achromobacter xylosoxidans and Stenotrophomonas maltophilia...... respiratory tract (nasal sampling) should be investigated and both infection sites should be treated....

  19. Barriers to adherence in cystic fibrosis

    DEFF Research Database (Denmark)

    Bregnballe, Vibeke; Schiøtz, Peter Oluf

    2012-01-01

    Danish patients with cystic fibrosis aged 14 to 25 years and their parents. Conclusions: The present study showed that the majority of adolescents with CF and their parents experienced barriers to treatment adherence. Patients and parents agreed that the three most common barriers encountered lack...

  20. Cystic fibrosis year in review 2016.

    Science.gov (United States)

    Savant, Adrienne P; McColley, Susanna A

    2017-08-01

    In this article, we highlight cystic fibrosis (CF) research and case reports published in Pediatric Pulmonology during 2016. We also include articles from a variety of journals that are thematically related to these articles, or are of special interest to clinicians. © 2017 Wiley Periodicals, Inc.

  1. Agmatine attenuates silica-induced pulmonary fibrosis.

    Science.gov (United States)

    El-Agamy, D S; Sharawy, M H; Ammar, E M

    2014-06-01

    There is a large body of evidence that nitric oxide (NO) formation is implicated in mediating silica-induced pulmonary fibrosis. As a reactive free radical, NO may not only contribute to lung parenchymal tissue injury but also has the ability to combine with superoxide and form a highly reactive toxic species peroxynitrite that can induce extensive cellular toxicity in the lung tissues. This study aimed to explore the effect of agmatine, a known NO synthase inhibitor, on silica-induced pulmonary fibrosis in rats. Male Sprague Dawley rats were treated with agmatine for 60 days following a single intranasal instillation of silica suspension (50 mg in 0.1 ml saline/rat). The results revealed that agmatine attenuated silica-induced lung inflammation as it decreased the lung wet/dry weight ratio, protein concentration, and the accumulation of the inflammatory cells in the bronchoalveolar lavage fluid. Agmatine showed antifibrotic activity as it decreased total hydroxyproline content of the lung and reduced silica-mediated lung inflammation and fibrosis in lung histopathological specimen. In addition, agmatine significantly increased superoxide dismutase (p Agmatine also reduced silica-induced overproduction of pulmonary nitrite/nitrate as well as tumor necrosis factor α. Collectively, these results demonstrate the protective effects of agmatine against the silica-induced lung fibrosis that may be attributed to its ability to counteract the NO production, lipid peroxidation, and regulate cytokine effects. © The Author(s) 2014.

  2. Pirfenidone treatment in idiopathic pulmonary fibrosis

    DEFF Research Database (Denmark)

    Salih, Goran Nadir; Shaker, Saher Burhan; Madsen, Helle Dall

    2016-01-01

    BACKGROUND: Pirfenidone was approved by the European Medicines Agency and introduced in most European countries in 2011 for treatment of idiopathic pulmonary fibrosis (IPF). OBJECTIVE: To describe the national Danish experiences of pirfenidone treatment for IPF during 30 months with respect...

  3. Inhalation of antibiotics in cystic fibrosis

    NARCIS (Netherlands)

    Touw, D J; Brimicombe, R W; Hodson, M E; Heijerman, H G; Bakker, W

    Aerosol administration of antipseudomonal antibiotics is commonly used in cystic fibrosis. However, its contribution to the improvement of lung function, infection and quality of life is not well-established. All articles published from 1965 until the present time concerning the inhalation of

  4. The cystic fibrosis of exocrine pancreas

    DEFF Research Database (Denmark)

    Wilschanski, Michael; Novak, Ivana

    2013-01-01

    The cystic fibrosis transmembrane conductance regulator (CFTR) protein is highly expressed in the pancreatic duct epithelia and permits anions and water to enter the ductal lumen. This results in an increased volume of alkaline fluid allowing the highly concentrated proteins secreted by the acina...... (CF) and pancreatitis, and outline present and potential therapeutic approaches in CF treatment relevant to the pancreas....

  5. Serum hyaluronic acid as a marker of hepatic fibrosis

    International Nuclear Information System (INIS)

    Khan, J.A.; Khan, F.A.; Ijaz, A.; Khan, N.A.; Mehmood, T.

    2007-01-01

    To determine the serum hyaluronic acid (HA) levels as biochemical marker of hepatic fibrosis and cirrhosis and correlate it with the degree of hepatic fibrosis and cirrhosis. This study was performed on 100 patients of chronic liver disease whose liver biopsies had been carried out. Fifty healthy controls were also included in the study. Routine liver function tests, hepatitis serology and serum hyaluronic acid levels were carried out on patients and controls. Liver biopsy of 100 patients revealed that 21 were in stage 0 fibrosis, 38 in stage 1 fibrosis, 26 in stage 3 fibrosis and 15 in stage 4 fibrosis. Mean Serum HA (mean +- SD) concentration in patients were 189 +- 98 mg/L vs. 21 +- 10 mg/L of healthy controls. The difference observed was statistically significant (p < 0.001). Patients in stage 4 fibrosis had significantly higher (p <0.001) mean serum HA concentration as compared to other stages of liver fibrosis. Diagnostic accuracy of serum HA at marginally elevated level of 60 mg/L determined the sensitivity 78.4 %, specificity 80.9%, positive predicted value 93.9% and negative predicted value of 50%. Serum HA is a useful non-invasive marker of liver fibrosis. There is a strong positive correlation between serum HA levels and degree of liver fibrosis. The concentration of serum HA rises according to progression of liver fibrosis and levels are highest in patients with liver cirrhosis. (author)

  6. Acute irradiation and muscular fibrosis. Development and characteristics in the pig

    International Nuclear Information System (INIS)

    Lefaix, J.L.; Daburon, F.; Remy, J.

    1989-01-01

    This study was performed in an experimental porcin model of acute local irradiation chosen to simulate human accidents. It enabled to determine the development and the physiopathological characteristics of the fibrous tissue which developed in skeletal muscle. In the first month after irradiation the strong inflammatory reaction initiating the radiation induced fibrosis was characterized by edema as visualized on NMR imaging and by acute phase reactant protein changes, associated with elevations of local and general temperatures in irradiated animals. At the margin of the irradiated tissue, atypical fibroblasts isolated among collagen bundles or bunched in nodullary reinforcement were seen associated with intense capillary neogenesis. Several months after irradiation normal skeletal muscle was replaced by atrophic fibrosis delimited by an inflammatory perifibrotic tissue. The muscular fibrosis was characterized by a high atypical fibroblasts density and by an inflammatory distribution pattern of collagen types I, III, IV, laminin, fibronectin and fibrinogen as visualized by immunohistochemical methods. Biochemical results showed an increase in collagen content and synthesis in fibrotic tissue whereas perifibrotic zone synthesized more non collagenous proteins compared with the normal muscle. The contributions of granulation tissue, cellular mediators and inhibition of muscular regeneration to maintain the atrophic character of the muscular radiation induced fibrosis are discussed [fr

  7. Endostatin and kidney fibrosis in aging: a case for antagonistic pleiotropy?

    Science.gov (United States)

    Lin, Chi Hua Sarah; Chen, Jun; Ziman, Bruce; Marshall, Shannon; Maizel, Julien; Goligorsky, Michael S

    2014-06-15

    A recurring theme of a host of gerontologic studies conducted in either experimental animals or in humans is related to documenting the functional decline with age. We hypothesize that elevated circulating levels of a powerful antiangiogenic peptide, endostatin, represent one of the potent systemic causes for multiorgan microvascular rarefaction and functional decline due to fibrosis. It is possible that during the life span of an organism there is an accumulation of dormant transformed cells producing antiangiogenic substances (endostatin) that maintain the dormancy of such scattered malignant cells. The proof of this postulate cannot be obtained by physically documenting these scattered cells, and it rests exclusively on the detection of sequelae of shifted pro- and antiangiogenic balance toward the latter. Here we compared circulating levels of endostatin in young and aging mice of two different strains and showed that endostatin levels are elevated in the latter. Renal expression of endostatin increased ~5.6-fold in aging animals. This was associated with microvascular rarefaction and progressive tubulointerstitial fibrosis. In parallel, the levels of sirtuins 1 and 3 were significantly suppressed in aging mice in conjunction with the expression of markers of senescence. Treating young mice with endostatin for 28 days showed delayed recovery of circulation after femoral artery ligation and reduced patency of renal microvasculature but no fibrosis. In conclusion, the findings are consistent with the hypothesis on elevation of endostatin levels and parallel microvascular rarefaction and induction of renal fibrosis in aging mice. Copyright © 2014 the American Physiological Society.

  8. Centralidad del trabajo y creencias asociadas en jóvenes estudiantes y adultos activos laboralmente

    OpenAIRE

    Beramendi, Maite; Ceballos, Samantha; Córdoba, Esteban; Iun Ferrero, Yamila; Sánchez, Mariana; Filippi, Graciela; Zubieta, Elena

    2007-01-01

    En el área de la psicología social del trabajo, los estudios muestran que la Competitividad y los valores asociados a la Ética Protestante del Trabajo (EPT) refieren a una orientación hacia el trabajo que enfatiza el trabajo duro, la conservación de recursos y la evitación de la haraganería. A su vez, este conjunto de valores actúa como un sistema cognitivo organizador a través del cual el mundo es percibido y explicado. Estudios previos indican que la actitud competitiva se asocia a una mayo...

  9. Últimos perfiles del accidente de trabajo en misión

    OpenAIRE

    Poquet Catalá, Raquel

    2017-01-01

    En este trabajo se analiza desde un punto de vista de la doctrina judicial y jurisprudencial la construcción doctrinal del accidente de trabajo en misión como derivación del accidente de trabajo in itinere y como configuración propia del accidente de trabajo en sí. Así, se procede a la delimitación respecto del accidente in itinere, se realiza un análisis de los requisitos configuradores del mismo, tanto genéricos como específicos, así como la aplicabilidad de la presunción iuris tantum de la...

  10. La tradición del trabajo de campo en Geografía

    Directory of Open Access Journals (Sweden)

    Perla Zusman

    2011-01-01

    Full Text Available El trabajo de campo ha adquirido distintas significaciones a lo largo de la historia de la Geografía. Los cambios en la concepción de la Geografía han derivado en redefiniciones de la contribución del trabajo de campo al proceso de producción de conocimiento. El objetivo de este texto es aproximarse a los aspectos epistemológicos y políticos presentes en las distintas formas de entender el trabajo de campo. A su vez, se busca mostrar que las diversas maneras de concebir y hacer el trabajo de campo conviven en la actualidad

  11. EVALUACION ERGONOMICA Y PSICOSOCIAL DE PUESTOS DE TRABAJO CON PANTALLA DE VISUALIZACION DE DATOS

    OpenAIRE

    Rosique-Molina, Vicente

    2012-01-01

    El presente trabajo se realiza como Trabajo Fin del Máster (TFM) de Prevención de Riesgos Laborales, Especialidad de Ergonomía y Psicosociología, y pretende plasmar los conocimientos teóricos adquiridos durante el curso realizando una Evaluación Ergonómica y Psicosocial de puestos de trabajo con Pantallas de Visualización de Datos (PVD), y demostrar que los métodos utilizados, el del Instituto Nacional de Seguridad e Higiene en el Trabajo (INSHT) para la evaluación ergonómica y el CoPsoQ I...

  12. El trabajo independiente en el proceso de enseñanza-aprendizaje

    OpenAIRE

    Soca Guevara, Edelmira Belkis

    2015-01-01

    El trabajo independiente forma parte del proceso de enseñanza aprendizaje y ejerce una importante influencia en la formación del estudiante en cualquier nivel de enseñanza. Una buena planificación del trabajo independiente por parte del profesor contribuye a elevar la calidad del proceso docente. En este trabajo se discute el beneficio de la utilización del formato web como soporte para la propuesta de cursos interactivos y dinámicos confeccionados por los profesores, como apoyo al trabajo in...

  13. El trabajo con cuerdas en los niños

    Directory of Open Access Journals (Sweden)

    Maureen Meneses Montero

    2004-01-01

    Full Text Available En la actualidad los niños se ven expuestos a diferentes situaciones ambientales que pueden poner en peligro su salud y conducirlos a manifestar hábitos con tendencias hacia el sedentarismo. Lo fundamental en esta etapa de la vida es mejorar sus destrezas básicas de movimiento, promoviendo una adecuada condición física desde edades tempranas. Se hace necesario entonces, apoyar programas que impliquen el mejoramiento de la aptitud física y motriz, principalmente los factores de coordinación, la resistencia cardiorrespiratoria, la fuerza y la flexibilidad. Estos componentes se deben fortalecer con el fin de satisfacer diferentes necesidades, de acuerdo con los objetivos planteados y con actividades variadas, que toman mayor importancia cuando se realizan de una forma divertida y con una metodología apropiada, como es el caso del salto de la cuerda, mediante la cual se tiende a incrementar la disposición de los niños hacia la práctica de estas actividades tradicionales, fundamentales para las siguientes etapas de desarrollo. El propósito principal del presente trabajo es plantear la importancia de la práctica del salto con la cuerda y estimular su enseñanza, tomando en cuenta aspectos técnicos, de organización y metodología, para promover el mejoramiento de la condición física de los niños por medio de las actividades propuestas

  14. LA ESPIRITUALIDAD Y LA RELIGIÓN EN EL TRABAJO

    Directory of Open Access Journals (Sweden)

    Guillermo Edelberg

    2013-07-01

    Full Text Available El Dr. Robert W. Mullins, apreciado colega fallecido hace unos años, era el director del Programa Máster en Administración de Empresas del INCAE a mi llegada a esta casa de estudios. En una oportunidad, poco antes de la graduación de un nuevo grupo de estudiantes, colocó una nota de despedida en una vitrina. La leí y me pareció? y sigue pareciendo? muy acertada en su contenido y brevedad. Próximos a ingresar al frío mundo real (as you enter the cold, real world, les deseaba suerte y éxito en sus carreras profesionales. En la actualidad, cuando leo u oigo acerca de la espiritualidad en el trabajo (spirituality in the workplace, me vienen a la memoria las palabras del Dr. Mullins porque ambas expresiones aparentan contradecirse. Si se tolera la espiritualidad en el frío mundo real ¿no será que el saludo del Dr. Mullins es menos acertado de lo que pensaba? ¿Qué se entiende por “espiritualidad en el trabajo”? La pregunta no es fácil de contestar. Las res-puestas parten tanto de un punto de vista religioso como de otro que evita toda referencia a una religión. Sumado a esto están las opiniones que señalan que el lugar de la espiritualidad se halla afuera de la empresa y las que dicen que se  trata de un tema viejo con un nombre nuevo o una nueva moda que es poco más que el sensitivity training de los años 50.

  15. Nutrient Status of Adults with Cystic Fibrosis

    Science.gov (United States)

    GORDON, CATHERINE M.; ANDERSON, ELLEN J.; HERLYN, KAREN; HUBBARD, JANE L.; PIZZO, ANGELA; GELBARD, RONDI; LAPEY, ALLEN; MERKEL, PETER A.

    2011-01-01

    Nutrition is thought to influence disease status in patients with cystic fibrosis (CF). This cross-sectional study sought to evaluate nutrient intake and anthropometric data from 64 adult outpatients with cystic fibrosis. Nutrient intake from food and supplements was compared with the Dietary Reference Intakes for 16 nutrients and outcomes influenced by nutritional status. Attention was given to vitamin D and calcium given potential skeletal implications due to cystic fibrosis. Measurements included weight, height, body composition, pulmonary function, and serum metabolic parameters. Participants were interviewed about dietary intake, supplement use, pulmonary function, sunlight exposure, and pain. The participants’ mean body mass index (±standard deviation) was 21.8±4.9 and pulmonary function tests were normal. Seventy-eight percent used pancreatic enzyme replacement for malabsorption. Vitamin D deficiency [25-hydroxyvitamin D (25OHD)<37.5 nmol/L] was common: 25 (39%) were deficient despite adequate vitamin D intake. Lipid profiles were normal in the majority, even though total and saturated fat consumption represented 33.0% and 16.8% of energy intake, respectively. Reported protein intake represented 16.9% of total energy intake (range 10%–25%). For several nutrients, including vitamin D and calcium, intake from food and supplements in many participants exceeded recommended Tolerable Upper Intake Levels. Among adults with cystic fibrosis, vitamin D deficiency was common despite reported adequate intake, and lipid profiles were normal despite a relatively high fat intake. Mean protein consumption was adequate, but the range of intake was concerning, as both inadequate or excessive intake may have deleterious skeletal effects. These findings call into question the applicability of established nutrient thresholds for patients with cystic fibrosis. PMID:18060897

  16. Datos normativos para el test de Span Visual: estudio evolutivo de la memoria de trabajo visual y la memoria de trabajo verbal

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    Sergio Hernández

    2012-06-01

    Full Text Available El objetivo central del presente trabajo ha sido la baremación en una amplia muestra de población infantil de una prueba destinada a la evaluación de la memoria de trabajo visual. Además, hemos abordado el estudio del desarrollo evolutivo de la memoria de trabajo verbal y la memoria de trabajo visual. Se seleccionó a una muestra de 1.030 sujetos con edades comprendidas entre los 6 años y 3 meses y los 12 años y 4 meses que cursaban entre primero y sexto de educación primaria. Las pruebas utilizadas fueron: el Span Visual de la Wechsler Memory Scale, tanto en su versión directa como inversa, para la memoria de trabajo visual y la adaptación al español de la prueba de Memoria de Frases de Siegel y Ryan para la memoria de trabajo verbal. Los resultados encontrados ponen de manifiesto una mejora progresiva en el rendimiento en función de la edad en ambas pruebas. Se presentan tablas de medias, desviación estándar y percentiles para los distintos grupos de edad. Estos datos podrán ser utilizados como referencia normativa por aquellos profesionales interesados en el estudio del funcionamiento ejecutivo de la población escolar infantil.

  17. Tiempo máximo aceptable de trabajo para tareas ejecutadas con miembros superiores e inferiores

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    Juan C. Velásquez V.

    2015-12-01

    Full Text Available Introducción: La carga física de trabajo es uno de los principales factores de riesgo a los que se enfrentan los trabajadores. En la actualidad los métodos propuestos para evaluar la carga física dinámica contemplan el trabajo con todo el cuerpo y no discriminan por segmentos corporales. Objetivo: Determinar el tiempo máximo aceptable de trabajo cuando el trabajo se ejecuta con todo el cuerpo, con los miembros superiores o los miembros inferiores. Métodos: Se realizó medición de consumo de oxígeno mediante ergoespirometria y monitorización de la frecuencia cardiaca en 30 trabajadores expuestos a diversas cargas ejecutadas con todo el cuerpo, miembros inferiores y miembros superiores. Se determinó el umbral anaeróbico por coeficiente respiratorio, el cual sirvió de base para de determinación del tiempo máximo aceptable de trabajo. Resultados: Los tiempos máximos aceptables de trabajo fueron similares para tareas con todo el cuerpo y con miembros inferiores, pero significativamente menores para tareas realizadas con miembros superiores. Se halló un modelo de correlación exponencial negativo entre en tiempo de trabajo, el consumo de oxígeno, y la frecuencia cardiaca, R > 0,9 en todos los casos. Se plantearon 9 ecuaciones de regresión para determinar el tiempo máximo aceptable de trabajo. Conclusiones: El tiempo máximo aceptable de trabajo para miembros inferiores y para todo el cuerpo se comportan de manera similar. El tiempo máximo aceptables de trabajo con miembros superiores es significativamente inferior a los anteriores. La frecuencia cardiaca relativa parece ser el mejor indicador para medir el tiempo máximo aceptables de trabajo en campo.

  18. Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice.

    Directory of Open Access Journals (Sweden)

    Hyon-Seung Yi

    Full Text Available Accumulating evidence suggests that retinol and its metabolites are closely associated with liver fibrogenesis. Recently, we demonstrated that genetic ablation of alcohol dehydrogenase 3 (ADH3, a retinol metabolizing gene that is expressed in hepatic stellate cells (HSCs and natural killer (NK cells, attenuated liver fibrosis in mice. In the current study, we investigated whether pharmacological ablation of ADH3 has therapeutic effects on experimentally induced liver fibrosis in mice.Liver fibrosis was induced by intraperitoneal injections of carbon tetrachloride (CCl4 or bile duct ligation (BDL for two weeks. To inhibit ADH3-mediated retinol metabolism, 10 μg 4-methylpyrazole (4-MP/g of body weight was administered to mice treated with CCl4 or subjected to BDL. The mice were sacrificed at week 2 to evaluate the regression of liver fibrosis. Liver sections were stained for collagen and α-smooth muscle actin (α-SMA. In addition, HSCs and NK cells were isolated from control and treated mice livers for molecular and immunological studies.Treatment with 4-MP attenuated CCl4- and BDL-induced liver fibrosis in mice, without any adverse effects. HSCs from 4-MP treated mice depicted decreased levels of retinoic acids and increased retinol content than HSCs from control mice. In addition, the expression of α-SMA, transforming growth factor-β1 (TGF-β1, and type I collagen α1 was significantly reduced in the HSCs of 4-MP treated mice compared to the HSCs from control mice. Furthermore, inhibition of retinol metabolism by 4-MP increased interferon-γ production in NK cells, resulting in increased apoptosis of activated HSCs.Based on our data, we conclude that inhibition of retinol metabolism by 4-MP ameliorates liver fibrosis in mice through activation of NK cells and suppression of HSCs. Therefore, retinol and its metabolizing enzyme, ADH3, might be potential targets for therapeutic intervention of liver fibrosis.

  19. Physical exercise training for cystic fibrosis.

    Science.gov (United States)

    Radtke, Thomas; Nevitt, Sarah J; Hebestreit, Helge; Kriemler, Susi

    2017-11-01

    Physical exercise training may form an important part of regular care for people with cystic fibrosis. This is an update of a previously published review. To assess the effects of physical exercise training on exercise capacity by peak oxygen consumption, pulmonary function by forced expiratory volume in one second, health-related quality of life and further important patient-relevant outcomes in people with cystic fibrosis. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Date of the most recent search: 04 May 2017.We searched ongoing trials registers (clinicaltrials.gov and the WHO ICTRP). Date of most recent search: 10 August 2017. All randomised and quasi-randomised controlled clinical trials comparing exercise training of any type and a minimum duration of two weeks with conventional care (no training) in people with cystic fibrosis. Two authors independently selected studies for inclusion, assessed methodological quality and extracted data. The quality of the evidence was assessed using the GRADE system. Of the 83 studies identified, 15 studies which included 487 participants, met the inclusion criteria. The numbers in each study ranged from nine up to 72 participants; two studies were in adults, seven were in children and adolescents and six studies included all age ranges. Four studies of hospitalised participants lasted less than one month and 11 studies were outpatient-based, lasting between two months and three years. The studies included participants with a wide range of disease severity and employed differing levels of supervision with a mixture of types of training. There was also wide variation in the quality of the included studies.This systematic review shows very low- to low-quality evidence from both short- and long-term studies that in people

  20. Crisis, ingresos y mercado de trabajo en Ecuador

    Directory of Open Access Journals (Sweden)

    2002-01-01

    Full Text Available Au court des dernières qannées, l'Équateur a traversé une profonde crise économique et politique. Les indicateurs d'inégalité, dont les déterminants sont sanalysés à fond dans ce travail, montrent des changements entre 1995 et 1998. Les données indiquent que les facteurs les plus significatifs qui expliquent l'inégalité sont : la scolarité, l'appartenance au secteur agricole, le sexe et le degré de formalité de l'emploi. En désagrégant ces caracteristiques de l'e´chantillon, les différentes contributions de chaque facteur à l'inégalité se manifestent. La raison pourrait en être les changements survenus dans la structure productive de la famille, parmi lesqueles se trouvent la participation des femmes et le phénomène migratoire, qui s'est accentué depuis 1998. Ecuador ha atravesado una profunda crisis económica y política los últimos años. Los indicadores de desigualdad, cuyos determinantes se analizan con profundidad en este trabajo, muestran variaciones entre 1995 y 1998. La evidencia indica que los factores más significativos para explicar la desigualdad son la escolaridad, la pertenencia al sector agrícola, el género y el grado de formalidad del empleo. Al desagregar la muestra por estas características, se encuentran diferencias en la forma en que cada uno de estos factores contribuyen a la desigualdad. La explicación se encontraría en que se han dado cambios en la estructura productiva de la familia, entre los cuales destacan la forma de participación de la mujer y un proceso migratorio al extranjero que se aceleró justamente a partir de 1998. In recent years, Ecuador has gone through a severe economic and political crisis. Inequality indicators for the 1995-1998 period, which are analized in depth in this paper, exhibit a rising trend. The evidence indicates that the most significant factors that contribute to inequality are education, belonging to the agricultural sector, gender, and the degree of

  1. Factors Promoting Development of Fibrosis in Crohn’s Disease

    Directory of Open Access Journals (Sweden)

    Gerhard Rogler

    2017-07-01

    Full Text Available The concepts on the pathophysiology of intestinal fibrosis in Crohn’s disease (CD have changed in recent years. Some years ago fibrosis was regarded to be a consequence of long-standing inflammation with subsequent destruction of the gut wall matrix followed by scar formation and collagen deposition. Fibrosis in CD patients appeared to be an irreversible process that could hardly be influenced. Therefore, the main target in CD therapy was to control inflammation to avoid fibrosis development. Many of these assumptions seem to be only partially true. Inflammation may be a necessary prerequisite for the initiation of fibrosis. However, when the pathophysiologic processes that lead to fibrosis in CD patients have been initiated fibrosis development may be independent of inflammation and may continue even when inflammation is under good medical control. Fibrosis in CD also may be reversible. After strictureplasty local collagen deposits decrease or even disappear. With new animal models for intestinal fibrosis on the horizon, we need to spend more efforts on understanding the factors influencing fibrosis in CD patients to finally find specific therapies. In this context, it will be as important to find markers and quantitative imaging tools to have reliable endpoints for clinical trials in fibrosing CD.

  2. Temas de Física para Ingeniería: Trabajo y energía

    OpenAIRE

    Beléndez, Augusto; Pastor Antón, Carlos; Bernabeu, Guillermo

    1988-01-01

    Apuntes de Mecánica: "Trabajo y energía". Trabajo y potencia. Energía cinética, teorema de la energía cinética. Fuerzas conservativas, energía potencial. Energía potencial gravitatoria. Principio de conservación de la energía mecánica. Choques.

  3. Historia reciente del trabajo y los trabajadores. Apuntes sobre lo tradicional y lo nuevo, lo que cambia y permanece en el mundo del trabajo

    Directory of Open Access Journals (Sweden)

    Roxana Albanesi

    2015-07-01

    Full Text Available Referirse al trabajo es hacer mención a un concepto complejo y multifacético. A su vez, los trabajadores constituyen un grupo social heterogéneo cuya ubicación en la estructura social es diversa. En este artículo se buscar reflexionar acerca de las características actuales del trabajo. Se presenta una breve reseña histórica que remite a las diferentes formas que asume la relación capital-trabajo en el tiempo para detenerse, con mayor profundidad, en las transformaciones ocurridas desde la crisis del capitalismo industrial hasta nuestros días. La reflexión acerca de lo que cambió y lo que permanece como tendencias en el mundo del trabajo depende de la periodización con que se aborde la cuestión. La evolución general del capitalismo muestra que la informalidad, la precariedad, la inestabilidad son condiciones clásicas del trabajo cuando se encuentra sujeto a mercados autorregulados. Las diferencias quedan claramente identificadas cuando se toma como referencia el período del Estado de Bienestar. Desde esta perspectiva temporal, la desigualdad de los ingresos entre diferentes ramas y al interior de un mismo grupo no constituye una novedad, pero sí lo son la degradación de las condiciones de trabajo y la desprotección social. En la historia reciente, esta situación es percibida por los trabajadores como un incremento de la vulnerabilidad y de los riesgos. El desempleo como realidad o como amenaza permanente, las condiciones flexibles del trabajo, el debilitamiento de la creencia en soluciones colectivas, la resignación social, la organización de estrategias individuales e individualistas, son rasgos distintivos de la historia reciente de los trabajadores.

  4. Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis

    Directory of Open Access Journals (Sweden)

    Flower Roderick J

    2011-10-01

    Full Text Available Abstract Background The balancing functions of pro/anti-inflammatory mediators of the complex innate responses have been investigated in a variety of experimental inflammatory settings. Annexin-A1 (AnxA1 is one mediator of endogenous anti-inflammation, affording regulation of leukocyte trafficking and activation in many contexts, yet its role in lung pathologies has been scarcely investigated, despite being highly expressed in lung cells. Here we have applied the bleomycin lung fibrosis model to AnxA1 null mice over a 21-day time-course, to monitor potential impact of this mediator on the control of the inflammatory and fibrotic phases. Results Analyses in wild-type mice revealed strict spatial and temporal regulation of the Anxa1 gene, e.g. up-regulation in epithelial cells and infiltrated granulocytes at day 7, followed by augmented protein levels in alveolar macrophages by day 21. Absence of AnxA1 caused increases in: i the degree of inflammation at day 7; and ii indexes of fibrosis (assessed by deposition of hydroxyproline in the lung at day 7 and 21. These alterations in AnxA1 null mice were paralleled by augmented TGF-β1, IFN-γ and TNF-α generation compared to wild-type mice. Finally, treatment of wild type animals with an AnxA1 peptido-mimetic, given prophylactically (from day 0 to 21 or therapeutically (from day 14 onward, ameliorated both signs of inflammation and fibrosis. Conclusion Collectively these data reveal a pathophysiological relevance for endogenous AnxA1 in lung inflammation and, more importantly, fibrosis, and may open new insights for the pharmacological treatment of lung fibrosis.

  5. A novel collaborative representation and SCAD based classification method for fibrosis and inflammatory activity analysis of chronic hepatitis C

    Science.gov (United States)

    Cai, Jiaxin; Chen, Tingting; Li, Yan; Zhu, Nenghui; Qiu, Xuan

    2018-03-01

    In order to analysis the fibrosis stage and inflammatory activity grade of chronic hepatitis C, a novel classification method based on collaborative representation (CR) with smoothly clipped absolute deviation penalty (SCAD) penalty term, called CR-SCAD classifier, is proposed for pattern recognition. After that, an auto-grading system based on CR-SCAD classifier is introduced for the prediction of fibrosis stage and inflammatory activity grade of chronic hepatitis C. The proposed method has been tested on 123 clinical cases of chronic hepatitis C based on serological indexes. Experimental results show that the performance of the proposed method outperforms the state-of-the-art baselines for the classification of fibrosis stage and inflammatory activity grade of chronic hepatitis C.

  6. Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling

    Directory of Open Access Journals (Sweden)

    Jiang Liu

    2012-01-01

    Full Text Available The Na/K-ATPase is the primary force regulating renal sodium handling and plays a key role in both ion homeostasis and blood pressure regulation. Recently, cardiotonic steroids (CTS-mediated Na/K-ATPase signaling has been shown to regulate fibrosis, renal proximal tubule (RPT sodium reabsorption, and experimental Dahl salt-sensitive hypertension in response to a high-salt diet. Reactive oxygen species (ROS are an important modulator of nephron ion transport. As there is limited knowledge regarding the role of ROS-mediated fibrosis and RPT sodium reabsorption through the Na/K-ATPase, the focus of this review is to examine the possible role of ROS in the regulation of Na/K-ATPase activity, its signaling, fibrosis, and RPT sodium reabsorption.

  7. Congenital Fibrosis of the Extraocular Muscles

    Directory of Open Access Journals (Sweden)

    Leyla Niyaz

    2014-08-01

    Full Text Available Congenital fibrosis of the extraocular muscles (CFEOM is a rare disorder characterized by hereditary non-progressive restrictive strabismus and blepharoptosis. Although most of the cases are bilateral and isolated, some patients may have systemic findings. CFEOM is divided into three groups as CFEOM 1, 2, and 3 according to the phenotype. Primary responsible genes are KIF21A for CFEOM type 1 and 3 and PHOX2A/ARIX gene for CFEOM type 2. Studies suggest that abnormal innervation of the extraocular muscles is the cause of muscle fibrosis. Early treatment is important because of the risk of amblyopia. Surgery is the primary treatment option for strabismus and blepharoptosis. (Turk J Ophthalmol 2014; 44: 312-5

  8. Cyclic Nucleotide Signalling in Kidney Fibrosis

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    Elisabeth Schinner

    2015-01-01

    Full Text Available Kidney fibrosis is an important factor for the progression of kidney diseases, e.g., diabetes mellitus induced kidney failure, glomerulosclerosis and nephritis resulting in chronic kidney disease or end-stage renal disease. Cyclic adenosine monophosphate (cAMP and cyclic guanosine monophosphate (cGMP were implicated to suppress several of the above mentioned renal diseases. In this review article, identified effects and mechanisms of cGMP and cAMP regarding renal fibrosis are summarized. These mechanisms include several signalling pathways of nitric oxide/ANP/guanylyl cyclases/cGMP-dependent protein kinase and cAMP/Epac/adenylyl cyclases/cAMP-dependent protein kinase. Furthermore, diverse possible drugs activating these pathways are discussed. From these diverse mechanisms it is expected that new pharmacological treatments will evolve for the therapy or even prevention of kidney failure.

  9. Lymphoplasmacytic Sclerosing Pancreatitis and Retroperitoneal Fibrosis

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    Nigel K. F. Koo Ng

    2008-01-01

    Full Text Available Although cases of lymphoplasmacytic sclerosing pancreatitis (LSP associated with idiopathic retroperitoneal fibrosis have been reported, the association is rare. We describe a 74-year-old man who presented with obstructive jaundice and weight loss. Nineteen months earlier, he had been diagnosed with idiopathic retroperitoneal fibrosis and treated with bilateral ureteric stents. Initial investigations were suggestive of a diagnosis of LSP, however, a malignant cause could not be ruled out. He underwent an exploratory laparotomy and frozen sections confirmed the diagnosis of LSP. An internal biliary bypass was performed using a Roux loop of jejunum, and the patient made an uneventful recovery. This case illustrates the difficulty in distinguishing LSP from pancreatic carcinoma preoperatively.

  10. Respiratory muscle training for cystic fibrosis.

    Science.gov (United States)

    Hilton, Nathan; Solis-Moya, Arturo

    2018-05-24

    Cystic fibrosis is the most common autosomal recessive disease in white populations, and causes respiratory dysfunction in the majority of individuals. Numerous types of respiratory muscle training to improve respiratory function and health-related quality of life in people with cystic fibrosis have been reported in the literature. Hence a systematic review of the literature is needed to establish the effectiveness of respiratory muscle training (either inspiratory or expiratory muscle training) on clinical outcomes in cystic fibrosis. This is an update of a previously published review. To determine the effectiveness of respiratory muscle training on clinical outcomes in people with cystic fibrosis. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials register comprising of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Date of most recent search: 17 April 2018.A hand search of the Journal of Cystic Fibrosis and Pediatric Pulmonology was performed, along with an electronic search of online trial databases up until 07 May 2018. Randomised controlled studies comparing respiratory muscle training with a control group in people with cystic fibrosis. Review authors independently selected articles for inclusion, evaluated the methodological quality of the studies, and extracted data. Additional information was sought from trial authors where necessary. The quality of the evidence was assessed using the GRADE system MAIN RESULTS: Authors identified 19 studies, of which nine studies with 202 participants met the review's inclusion criteria. There was wide variation in the methodological and written quality of the included studies. Four of the nine included studies were published as abstracts only and lacking concise details, thus limiting the information available. Seven studies were parallel studies and two of a cross-over design. Respiratory

  11. Nephrogenic systemic fibrosis: history and epidemiology

    DEFF Research Database (Denmark)

    Thomsen, Henrik S

    2009-01-01

    Nephrogenic systemic fibrosis (NSF) is a new disease; the first case was diagnosed in 1997. It took 9 years before an association between NSF and gadolinium-based contrast agents (Gd-CAs) was identified. Gadolinium has several advantages for use in relation to enhanced MRI, but it is also a toxic...... that the real number of patients who have NSF has not been accurately totaled; the disease seems to be underdiagnosed for various reasons....

  12. Noncirrhotic portal fibrosis after Wilms' tumor therapy

    International Nuclear Information System (INIS)

    Barnard, J.A.; Marshall, G.S.; Neblett, W.W.; Gray, G.; Ghishan, F.K.

    1986-01-01

    A 9-yr-old girl developed massive hemorrhage from esophageal varices 2 yr after combined modality therapy for Wilms' tumor. Evaluation showed a patent extrahepatic portal venous system and an elevated splenic pulp pressure. In contrast to previous reports of hepatopathy after irradiation injury, histologic sections of the liver did not demonstrate occlusion of the central veins, but rather a diffuse obliteration of intrahepatic portal venous radicles. This pattern of noncirrhotic portal fibrosis has not been described following antitumor therapy

  13. MR imaging of pancreas in cystic fibrosis

    International Nuclear Information System (INIS)

    Murayama, S.; Robinson, A.E.; Mulvihill, D.M.; Stallworth, J.M.; Goyco, P.G.; Beckerman, R.C.; Hines, M.R.

    1990-01-01

    The pancreatic regions of 18 patients with cystic fibrosis were analyzed with a 1.5 Tesla MR unit. Signal intensity of the pancreas was correlated with clinical data and ultrasound. A hyperintense pancreas on T1-weighted image was consistent with fatty replacement of pancreatic insufficiency. A pancreas of normal soft tissue intensity was found in two asymptomatic and one symptomatic patient. A very hypointense pancreas on any pulse sequence was considered to be an intermediate stage of pancreatic degeneration. (orig.)

  14. Cystic fibrosis Delta F508 heterozygotes, smoking, and reproduction

    DEFF Research Database (Denmark)

    Dahl, Morten; Tybjaerg-Hansen, A; Wittrup, H H

    1998-01-01

    Cystic fibrosis is the most common fatal autosomal recessive disease affecting Caucasian populations. It remains a puzzle how this disease is maintained at such a remarkably high incidence, however, it could be due to a reproductive advantage in cystic fibrosis heterozygotes. We tested this hypot......Cystic fibrosis is the most common fatal autosomal recessive disease affecting Caucasian populations. It remains a puzzle how this disease is maintained at such a remarkably high incidence, however, it could be due to a reproductive advantage in cystic fibrosis heterozygotes. We tested.......001). In conclusion, overall these results do not support a reproductive advantage for cystic fibrosis DeltaF508 heterozygotes. However, the data cannot totally exclude the possibility that nonsmoking DeltaF508 heterozygotes experience a reproductive advantage while smoking DeltaF508 heterozygotes experience...... the opposite, a reproductive disadvantage. Accordingly, the data suggest a previously undocumented role of smoking on fecundity among cystic fibrosis heterozygotes....

  15. Pregnancy and cystic fibrosis: Approach to contemporary management

    Science.gov (United States)

    Tay, George; Callaway, Leonie; Bell, Scott C

    2014-01-01

    Over the previous 50 years survival of patients with cystic fibrosis has progressively increased. As a result of improvements in health care, increasing numbers of patients with cystic fibrosis are now considering starting families of their own. For the health care professionals who look after these patients, the assessment of the potential risks, and the process of guiding prospective parents through pregnancy and beyond can be both challenging and rewarding. To facilitate appropriate discussions about pregnancy, health care workers must have a detailed understanding of the various important issues that will ultimately need to be considered for any patient with cystic fibrosis considering parenthood. This review will address these issues. In particular, it will outline pregnancy outcomes for mothers with cystic fibrosis, issues that need to be taken into account when planning a pregnancy and the management of pregnancy for mothers with cystic fibrosis or mothers who have undergone organ transplantation as a result of cystic fibrosis. PMID:27512443

  16. Establecimiento de una colección de trabajo de uchuva del suroccidente colombiano

    Directory of Open Access Journals (Sweden)

    Martha Liliana Bonilla Betancourt

    2008-06-01

    Full Text Available Physalis peruviana L. es una especie frutícola promisoria para la zona andina colombiana; sin embargo, no ha sido un recurso genético prioritario de conservación. En el estudio se estableció una colección de trabajo registrada en una base de datos computarizada de 222 accesiones recolectadas en los departamentos de Nariño, Valle del Cauca, Cauca, Caldas, Quindío y Cundinamarca que representan la variabilidad existente de cultivariedades nativas y espontáneas. Las semillas del material recolectado se encuentran en el cuarto frío del Centro Experimental de la Universidad Nacional de Colombia sede Palmira. Esta colección contribuye a la conservación y al estudio de la diversidad de esta especie y a la disponibilidad de una base genética para futuros programas de selección y mejoramiento genético.

  17. Smoking and Pulmonary Fibrosis: Novel Insights

    Directory of Open Access Journals (Sweden)

    Katerina D. Samara

    2011-01-01

    Full Text Available The relationship between smoking and pulmonary fibrosis is under debate and intense investigation. The aim of this paper is to review the existing literature and identify further areas of research interest. Recently the negative influence of cigarette smoking on IPF outcome was highlighted, as non-smokers exhibit a better survival than ex-smokers and combined current- and ex-smokers. In patients with non-specific interstitial pneumonia (NSIP, a high prevalence of emphysema was recently demonstrated, providing an indirect support for a smoking pathogenetic hypothesis in NSIP. The coexistence of pulmonary fibrosis and emphysema has been extensively described in a syndrome termed combined pulmonary fibrosis and emphysema (CPFE. Connective tissue disorders (CTDs are a group of autoimmune diseases which affect the lung, as one of the most common and severe manifestations. However, the relationship between smoking and autoimmune disorders is still conflicting. Rheumatoid arthritis results from the interaction between genetic and environmental factors, while the best established environmental factor is tobacco smoking. Smoking has also a negative impact on the response of the RA patients to treatment. The aforementioned smoking-related implications give rise to further research questions and certainly provide one more important reason for physicians to advocate smoking cessation and smoke-free environment.

  18. Eosinophilic Angiocentric Fibrosis of the Nasal Septum

    Directory of Open Access Journals (Sweden)

    Yunchuan Li

    2013-01-01

    Full Text Available Background. Eosinophilic angiocentric fibrosis (EAF is a rare benign condition of unknown aetiology that causes stenosis of the upper respiratory tract. It is most commonly found at the nasal septum and sinus mucosa causing mucosal thickening and nasal obstructive symptoms. The diagnosis is mainly based on characteristic histologic findings. Case Report. A 27-year-old young woman presented with a slow growing mass at her anterior nasal septum for over eight years. She complained of persistent nasal obstruction, epistaxis, sometimes diffused facial pain, and chronic headache. 3 years ago, the tumor was partially resected for ventilation and a nasal septum perforation was left. Imaging findings indicated soft-tissue thickening of the anterior part of septum and adjacent lateral nasal walls. Pathological examination showed numerous inflammatory cells infiltrates containing eosinophils, fibroinflammatory lesion with a whorled appearance fibrosis which typically surrounded vessels. A diagnosis of eosinophilic angiocentric fibrosis was made. All laboratory tests were unremarkable. Skin prick test was positive. The tumor-like lesion was totally resected. Conclusions. EAF is a rare benign and progressive disorder causing destruction. Combined with radiological imaging of EAF historical findings contribute to the diagnosis. It is important to prevent tumor from recurrence by total resection of the lesion.

  19. Subcutaneous fibrosis after whole neck irradiation

    International Nuclear Information System (INIS)

    Hirota, Saeko; Tsujino, Kayoko; Oshitani, Takashi; Hishikawa, Yoshio; Takada, Yoshiki; Kono, Michio; Abe, Mitsuyuki

    2002-01-01

    Purpose: To identify the risk factors for moderate to severe subcutaneous fibrosis after whole neck irradiation. Methods and Materials: We analyzed 233 cases of patients who had undergone whole neck irradiation with 4-MV X-ray or 8-10-MeV electrons, or both, and had been followed with regard to their skin condition for at least 1 year. The prescribed dose to the whole neck ranged from 19.2 to 72.4 Gy (median 50). The skin-absorbed dose was specified as that at a depth of 4.1 mm (d4.1-mm depth ), and a biologically equivalent dose (BED) of d4.1-mm depth was also estimated (BED 1.8 4.1-mm depth ). Results: Univariate analysis revealed that previous neck dissection, concurrent chemotherapy, corticosteroid administration as a part of chemotherapy, fractionation, and BED 1.8 4.1-mm depth were significant prognostic variables. Multivariate analysis showed that BED 1.8 4.1-mm depth and previous neck dissection were the only prognostic variables for moderate to severe subcutaneous fibrosis. Conclusion: A high dose to a 4.1-mm depth of the skin and a history of neck dissection were identified as the predominant risk factors for moderate to severe subcutaneous fibrosis after whole neck irradiation. A subcutaneous dose should be considered in radiotherapy treatment planning involving the whole neck, especially in cases in which patients have undergone previous neck dissection

  20. Cystic fibrosis: a mucosal immunodeficiency syndrome

    Science.gov (United States)

    Cohen, Taylor Sitarik; Prince, Alice

    2013-01-01

    Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that regulates the transport of ions and the movement of water across the epithelial barrier. Mutations in CFTR, which form the basis for the clinical manifestations of cystic fibrosis, affect the epithelial innate immune function in the lung, resulting in exaggerated and ineffective airway inflammation that fails to eradicate pulmonary pathogens. Compounding the effects of excessive neutrophil recruitment, the mutant CFTR channel does not transport antioxidants to counteract neutrophil-associated oxidative stress. Whereas mutant CFTR expression in leukocytes outside of the lung does not markedly impair their function, the expected regulation of inflammation in the airways is clearly deficient in cystic fibrosis. The resulting bacterial infections, which are caused by organisms that have substantial genetic and metabolic flexibility, can resist multiple classes of antibiotics and evade phagocytic clearance. The development of animal models that approximate the human pulmonary phenotypes—airway inflammation and spontaneous infection—may provide the much-needed tools to establish how CFTR regulates mucosal immunity and to test directly the effect of pharmacologic potentiation and correction of mutant CFTR function on bacterial clearance. PMID:22481418

  1. [Endocrine complications of cystic fibrosis in childhood].

    Science.gov (United States)

    Castanet, M; Wieliczko, M-C

    2012-05-01

    Since the 20 last years, the median age of survival has dramatically improved in children suffering from cystic fibrosis and complications such as growth retardation, pubertal delay and low bone mineral density are now more often than not observed in affected adolescents. The severity of the disease and the poor nutritional status due to pancreatic insufficiency and malabsorption are commonly implicated but recent data suggest that the disease could also play a role though the alteration of the chlore chanel (CFTR). Furthermore an increase prevalence of glucose intolerance and diabetes due to the progressive β cells destruction is observed in these children that make the life sometimes difficult for these adolescents already affected by an heavy chronic disease. The monitoring of the children should thus now become pluridisciplinary and include regular clinical evaluation of height and pubertal status, mineral bone density by DEXA and OGTT every two years since 10 years of age. Therefore, in addition to the standard treatment of cystic fibrosis is now added the vitamin D supplementation, the subcutaneous insulin therapy and may be the growth hormone that could be a new therapeutic demonstrating beneficial effects in these chronic disease. However further studies need to be performed to improve the management of these new endocrine complications more and more frequent in children and adolescents suffering from cystic fibrosis. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  2. Octreotide inhibits hepatic fibrosis, bile duct proliferation and bacterial translocation in obstructive jaundice.

    Science.gov (United States)

    Türkçapar, Nuran; Bayar, Sancar; Koyuncu, Ayhan; Ceyhan, Koray

    2003-01-01

    The protective effect of octreotide on bacterial translocation, bile duct epithelial proliferation and hepatic fibrosis was studied in an experimental obstructive jaundice model. Forty-five healthy Wistar albino rats were randomly divided into three groups. Group I (n = 15): Median laparotomy and common bile duct manipulation performed (Sham group). Group II (n = 15): Laparotomy and common bile duct ligation performed. Group III (n = 15): After laparotomy and common bile duct ligation octreotide (Sandostatin, sandoz) was given. Simultaneously group I and II received 3 cc 0.9% NaCl and group III received 20 micrograms/kg/daily octreotide subcutaneously every 8 hours during 9 days. Two days after the procedure all rats were opened under ether anesthesia and sterile conditions. Group I had simple laparotomy but group II and III also had common bile duct ligation by 5/0 prolene. Seven days after the surgery (9th day after treatment) all rats underwent laparotomy and tests for bacterial translocation, liver biochemical tests and histopathologic analysis of liver and small bowel were carried out. In group II cecal population levels of bacteria were significantly higher than group I and group III (p fibrosis in response to biliary obstruction. This experimental study showed that octreotide is effective in preventing bacterial translocation, bile duct proliferation and hepatic fibrosis in obstructive jaundice.

  3. MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?

    Science.gov (United States)

    Mölleken, Christian; Poschmann, Gereon; Bonella, Francesco; Costabel, Ulrich; Sitek, Barbara; Stühler, Kai; Meyer, Helmut E; Schmiegel, Wolff H; Marcussen, Niels; Helmer, Michael; Nielsen, Ole; Hansen, Søren; Schlosser, Anders; Holmskov, Uffe; Sorensen, Grith Lykke

    2016-03-29

    Several comparable mechanisms have been identified for hepatic and pulmonary fibrosis. The human microfibrillar associated glycoprotein 4 (MFAP4), produced by activated myofibroblasts, is a ubiquitous protein playing a potential role in extracellular matrix (ECM) turnover and was recently identified as biomarker for hepatic fibrosis in hepatitis C patients. The current study aimed to evaluate serum levels of MFAP4 in patients with pulmonary fibrosis in order to test its potential as biomarker in clinical practice. A further aim was to determine whether MFAP4 deficiency in mice affects the formation of pulmonary fibrosis in the bleomycin model of lung fibrosis. 91 patients with idiopathic pulmonary fibrosis (IPF), 23 with hypersensitivity pneumonitis (HP) and 31 healthy subjects were studied. In the mouse model, C57BL/6 Mfap4+/+ and Mfap4-/- mice between 6-8 weeks of age were studied. Serum levels of MFAP4 were measured by ELISA in patients and in mice. Surfactant protein D (SP-D) and LDH were measured as comparison biomarkers in patients with pulmonary fibrosis. Morphometric assessment and the Sircol kit were used to determine the amount of collagen in the lung tissue in the mouse model. Serum levels of MFAP4 were not elevated in lung fibrosis - neither in the patients with IPF or HP nor in the animal model. Furthermore no significant correlations with pulmonary function tests of IPF patients could be found for MFAP4. MFAP4 levels were increased in BAL of bleomycin treated mice with pulmonary fibrosis. MFAP4 is not elevated in sera of patients with pulmonary fibrosis or bleomycin treated mice with pulmonary fibrosis. This may be due to different pathogenic mechanisms of liver and lung fibrogenesis. MFAP4 seems to be useful as serum biomarker for hepatic but not for lung fibrosis.

  4. El Efecto del Acoso Psicológico en el Trabajo sobre la Salud: El Papel Mediador del Conflicto Trabajo- Familia

    Directory of Open Access Journals (Sweden)

    Ana Isabel Sanz-Vergel

    2011-01-01

    Full Text Available Los efectos de los estresores psicosociales pueden influir en la vida personal, afectando a la salud. El objetivo de este estudio es analizar el papel mediador del conflicto trabajo-familia en la relación entre el acoso psicológico en el trabajo y problemas de salud. La muestra del estudio estuvo formada por 441 trabajadores de tres empresas del sector de telecomunicaciones ubicadas en la Comunidad de Madrid. Los resultados muestran que el acoso psicológico tiene efectos negativos sobre la salud de forma directa, e indirecta mediante el conflicto trabajo-familia, actuando éste último como mediador parcial. Este hallazgo tiene implicaciones a nivel teórico, puesto que muestra que los efectos negativos de un estresor como es el acoso, se pueden transmitir a través de un conflicto que tiene lugar fuera del ámbito laboral.

  5. Análisis de recursividad estructural con trabajo especializado en la teoría de la inexistencia del mercado de trabajo

    Directory of Open Access Journals (Sweden)

    Juan Roberto Vargas Sánchez

    2015-01-01

    Full Text Available Se desarrolla un an lisis de recursividad estructural tomando como base la teor a de la inexistencia del mercado de trabajo ( . Para lo cual, se incorpora trabajo es - pecializado en el modelo b sico de la , en particular en la organizaci n interna de las empresas, de ah que la producci n sea posible mediante dos especialidades del trabajo indispensables para producir la gesti n y la manufactura. Se demuestra que si el diferencial salarial que resulta de las distintas remuneraciones a las diferentes espe - cialidades no se modifica, el desempleo en el subsector de los trabajadores-gesti n lo genera en el subsector de los trabajadores-manufactura; para restaurar el pleno empleo en el ltimo subsector mencionado, se requiere que el diferencial salarial se incremente. Adem s, se muestra que la existencia de desempleo en el subsector de los trabajadores- manufactura, la ocasiona en el subsector de los trabajadores-gesti n.

  6. Genetic modifiers of nutritional status in cystic fibrosis1234

    OpenAIRE

    Bradley, Gia M; Blackman, Scott M; Watson, Christopher P; Doshi, Vishal K; Cutting, Garry R

    2012-01-01

    Background: Improved nutrition early in life is associated with better pulmonary function for patients with cystic fibrosis (CF). However, nutritional status is poorly correlated with the CFTR genotype.

  7. Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis.

    Directory of Open Access Journals (Sweden)

    Jody Groenendyk

    Full Text Available Cardiac fibrosis attributed to excessive deposition of extracellular matrix proteins is a major cause of heart failure and death. Cardiac fibrosis is extremely difficult and challenging to treat in a clinical setting due to lack of understanding of molecular mechanisms leading to cardiac fibrosis and effective anti-fibrotic therapies. The objective in this study was to examine whether unfolded protein response (UPR pathway mediates cardiac fibrosis and whether a pharmacological intervention to modulate UPR can prevent cardiac fibrosis and preserve heart function.We demonstrate here that the mechanism leading to development of fibrosis in a mouse with increased expression of calreticulin, a model of heart failure, stems from impairment of endoplasmic reticulum (ER homeostasis, transient activation of the unfolded protein response (UPR pathway and stimulation of the TGFβ1/Smad2/3 signaling pathway. Remarkably, sustained pharmacologic inhibition of the UPR pathway by tauroursodeoxycholic acid (TUDCA is sufficient to prevent cardiac fibrosis, and improved exercise tolerance.We show that the mechanism leading to development of fibrosis in a mouse model of heart failure stems from transient activation of UPR pathway leading to persistent remodelling of cardiac tissue. Blocking the activation of the transiently activated UPR pathway by TUDCA prevented cardiac fibrosis, and improved prognosis. These findings offer a window for additional interventions that can preserve heart function.

  8. Idiopathic pulmonary fibrosis in a Staffordshire bull terrier with hypothyroidism.

    Science.gov (United States)

    Corcoran, B M; Dukes-McEwan, J; Rhind, S; French, A

    1999-04-01

    Radiographic evidence of chronic interstitial lung changes, usually believed to be attributable to lung fibrosis, is readily recognised in canine practice. Furthermore, there is a body of anecdotal evidence suggesting that a specific clinical entity consistent with chronic lung fibrosis occurs in specific breeds of terrier dogs. However, there is little pathological data to confirm these radiographic and clinical findings and, therefore, chronic interstitial lung disease of dogs is poorly characterised. In this report, a case of chronic pulmonary fibrosis is described in which histopathological confirmation was possible, and suggested that the condition might be analogous to idiopathic pulmonary fibrosis (cryptogenic fibrosing alveolitis) in humans.

  9. Fibrosis pulmonar asociada a vasculitis con anticuerpos anticitoplasmáticos positivos Pulmonary fibrosis associated with anti-neutrophil cytoplasmic antibody-positive vasculitis

    Directory of Open Access Journals (Sweden)

    Marcelo Fernández Casares

    2012-08-01

    Full Text Available Las complicaciones pulmonares más conocidas de las vasculitis con anticuerpos anticitoplasmáticos de los neutrófilos (ANCA positivos (VAA, son la hemorragia alveolar, los granulomas y la estenosis de la vía aérea. En los últimos años han aparecido algunos informes aislados que muestran la asociación con fibrosis pulmonar (FP, sugiriendo que ésta sería otra complicación de las VAA. En este trabajo informamos dos casos con dicha asociación describiendo sus características clínicas, tomográficas e inmunológicas. Dado que en la asociación de FP y VAA notificada en los últimos años, la FP puede ser su primera manifestación, podría ser necesaria la búsqueda de ANCA en pacientes con FP, como causa de la misma y por el posible desarrollo posterior de vasculitis.The most frequently observed pulmonary complications of vasculitis (AAV with anti-neutrophil cytoplasmic positive antibodies (ANCA are alveolar hemorrhage, granulomas and airway stenosis. In recent years, some reports have been published that show the association of vasculitis with pulmonary fibrosis (PF, suggesting that it may be another complication of AAV. We report and describe here two cases with such association, and their clinical, tomographic and immunological characteristics. Given that in the association between PF and AAV, as reported in the last years, PF could be the first manifestation of AAV, the search for ANCA in patients with PF may be necessary, as a cause of it and for the possible subsequent development of vasculitis.

  10. Diversidad y educación: el caso del trabajo infantil

    Directory of Open Access Journals (Sweden)

    María Alejandra Silva

    2017-12-01

    Full Text Available Objetivo: conocer los determinantes sociales del trabajo infantil y las políticas para la diversidad en trabajo y educación en Corrientes,  ubicada en el nordeste de Argentina (NEA desde un punto existencial. Método: Se acude al análisis de documentos y estadísticas, además de la consulta a informantes calificados en trabajo y educación. Resultados: El análisis estadístico muestra que las enormes desigualdades regionales persistentes y los problemas de extrema pobreza infantil proporcionan condiciones para que el trabajo infantil aumente. En cuanto a la naturaleza y perfil del trabajo infantil en Corrientes, se observa que hay diversidad de sexo, edad, cultura, tipo de trabajo, duración del día, etc. Conclusiones: El trabajo infantil constituye una flagrante violación de los derechos humanos, que necesita erradicarse a partir de numerosas políticas interministeriales e intersectoriales, siendo necesario políticas de y para la diversidad en educación a fin de incorporar al sistema educativo. Existen informaciones parciales y limitadas, faltando datos oficiales de toda la Provincia, lo que impide pensar en las políticas en y para la diversidad en la escuela que los incluya a través de nuevas metodologías, contenidos, recursos, docentes y gestores proactivos.

  11. ¿TRABAJO EXTRAÑADO, OCIO EXTRAÑADO? REFLEXIONES ACERCA DEL EXTRAÑAMIENTO DEL TRABAJO SOBRE EL OCIO

    OpenAIRE

    Silvestre, Bruno Modesto; Amaral, Silvia Cristina Franco

    2016-01-01

    El presente ensayo busca tejer reflexiones sobre el extrañamiento del trabajo sobre el ocio. Para esto, vamos a partir de análisis de la categoría trabajo y de las cuatro dimensiones del extrañamiento humano apuntadas por Marx en los Manuscritos Económicos y Filosóficos de 1844, en el que los seres humanos están ajenos: (1) a los productos o resultados de sus actividades, (2) al proceso de realización de la actividad, (3) a si mismo y a otros seres humanos y (4) a la naturaleza en que viven. ...

  12. Oral calorie supplements for cystic fibrosis.

    Science.gov (United States)

    Smyth, Rosalind L; Rayner, Oli

    2017-05-04

    Poor nutrition occurs frequently in people with cystic fibrosis and is associated with other adverse outcomes. Oral calorie supplements are used to increase total daily calorie intake and improve weight gain. However, they are expensive and there are concerns they may reduce the amount of food eaten and not improve overall energy intake. This is an update of a previously published review. To establish whether in people with cystic fibrosis, oral calorie supplements: increase daily calorie intake; and improve overall nutritional intake, nutritional indices, lung function, survival and quality of life. To assess adverse effects associated with using these supplements. We searched the Cochrane Cystic Fibrosis Trials Register comprising references from comprehensive electronic database searches, handsearches of relevant journals and abstract books of conference proceedings. We contacted companies marketing oral calorie supplements.Last search: 18 October 2016. Randomised or quasi-randomised controlled trials comparing use of oral calorie supplements for at least one month to increase calorie intake with no specific intervention or additional nutritional advice in people with cystic fibrosis. We independently selected the included trials, assessed risk of bias and extracted data. We contacted the authors of included trials and obtained additional information for two trials. We identified 21 trials and included three, reporting results from 131 participants lasting between three months and one year. Two trials compared supplements to additional nutritional advice and one to no intervention. Two of the included trials recruited only children. In one trial the risk of bias was low across all domains, in a second trial the risk of bias was largely unclear and in the third mainly low. Blinding of participants was unclear in two of the trials. Also, in one trial the clinical condition of groups appeared to be unevenly balanced at baseline and in another trial there were

  13. Trabajo y empleo de las mujeres en contexto de globalización

    OpenAIRE

    2004-01-01

    La presente publicación, que con mucho agrado les estamos entregando a Uds. llamada "Trabajo y empleo de las mujeres colombianas en contexto de globalización", es un esfuerzo de presentar las miradas y apuestas desde la investigación y sistematización colectiva, hasta la presentación de debates y propuestas de abordaje de las políticas laborales en Colombia de diversas autoras de la Mesa de Trabajo Mujeres y Economía. Este trabajo fue y esta apoyado por OXFAM G.B. y se recoge para la Campaña ...

  14. El análisis histórico del trabajo agrario : cuestiones recientes

    OpenAIRE

    Sarasúa García, Carmen

    2000-01-01

    Este artículo analiza algunas de las principales contribuciones hechas en la última década al estudio de la organización del trabajo agrícola. Trata seis aspectos en concreto: la demanda de trabaja agrícola, los costes del trabajo, la oferta de trabaja (en especial las diferentes formas de definir y cuantificar la población `activa` del sector primario), la productividad agrícola, el marco institucional, y la estructura interna de la fuerza de trabajo agrícoia (la competencia entre los trabaj...

  15. El enriquecimiento trabajo-familia y la satisfacción docente

    OpenAIRE

    Jijena Michel, Robert Daniel; Martínez Sánchez, Ángel; Pérez Pérez, Manuela

    2012-01-01

    INTRODUCCIÓN Psicólogos y asesores industriales/organizacionales han estado durante mucho tiempo preocupados por comprender los factores responsables de la satisfacción en el trabajo, que puede definirse como el grado en que a la gente le gusta su trabajo, ya sea en su totalidad o con respecto a condiciones o recompensas particulares (Spector, 1997). Una serie de modelos teóricos han sido desarrollados para explicar la satisfacción en el trabajo. Cada uno de estos modelos cuenta con un conj...

  16. Trabajo femenino y brecha de ingresos por género en Venezuela.

    OpenAIRE

    Genny Zuñiga; María Beatriz Orlando

    2001-01-01

    Este trabajo estudia la situación de la mujer en el mercado de trabajo venezolano en cuanto a su participación y el nivel de ingreso laboral obtenido. En la evolución de la participación de la mujer en el mercado de trabajo destaca la importancia de la edad, situación conyugal, nivel educativo, fecundidad y área de residencia como factores determinantes de la misma. Existen diferencias de ingreso medio entre hombres y mujeres, favorables a los primeros, que son más marcadas en el sector infor...

  17. Percepción de la mujer ejecutiva sobre su trabajo y vida familiar

    OpenAIRE

    Cárdenas Sánchez, Moraima Victoria; Estela Basaldua, Raúl Alfredo; Noriega de la Melena, Danny; Portales Bernal, William Jesús

    2016-01-01

    La investigación busca identificar la percepción de la mujer ejecutiva sobre su trabajo, vida familiar y la interacción trabajo-vida familiar, con la finalidad de obtener información que pueda ser útil para las empresas y Estado, y que esta información sea referenciada al momento de elaborar planes relacionados a promover el balance entre el trabajo-vida familiar. Para ello, se realizó una investigación cualitativa, se entrevistó a 28 mujeres ejecutivas de Lima, que tienen pers...

  18. Procedimiento de formación de grupos de trabajo en el proceso software

    OpenAIRE

    Digión, Leda

    2005-01-01

    Para conseguir calidad en el trabajo de un equipo de proyecto informático, no es suficiente con determinar el rol funcional del individuo (analista, programador, etc.) es decir, formar el equipo en función de las tareas a desempeñar. También es necesario identificar el estilo de trabajo de cada integrante, y según este estilo definir grupos de trabajo a cargo de cada subproceso de gestión, dentro del equipo de proyecto informático. A partir de una diferenciación entre los conceptos de grup...

  19. Desarrollo metodológico para medir el trabajo en equipo

    OpenAIRE

    Elisabeth Viles; Carmen Jaca; Martín Tanco; Allan Medina

    2011-01-01

    En el sector sanitario, el trabajo en equipo es una parte importante de su actividad. Aunque el sector fomenta la investigación orientada a mejorar la calidad del trabajo en equipo, pocas veces se focaliza a la evaluación de este proceso. Por esta razón en el presente artículo se desarrolla una propuesta metodológica para evaluar la efectividad del trabajo en equipo. Para ello el modelo contempla 36 factores que son utilizados para su medición, a través de la observación de la existencia, imp...

  20. Ambiente de trabajo cooperativo en internet para la educación en valores

    OpenAIRE

    Ingaluque Arapa, Marga Isabel

    2009-01-01

    El presente trabajo de investigación que lleva por título "AMBIENTE DE TRABAJO COOPERATIVO EN INTERNET PARA LA EDUCACION EN VALORES" responde a la necesidad de desarrollar nuevas formas de planificar y desarrollar la educación, de manera que se promueva la participación sincrónica y asincrónica entre tos sujetos que no se encuentran físicamente en el mismo lugar, ni en las mismas coordenadas temporales. El objetivo fue desarrollar un Ambiente de Trabajo Cooperativo en Internet para la educaci...

  1. ASOCIACIÓN ENTRE VALORES DE TRABAJO, INTERESES PROFESIONALES Y RASGOS DE PERSONALIDAD

    OpenAIRE

    Pinto, Lariana Paula; Noronha, Ana Paula Porto; Rueda, Fabián Javier Marín

    2017-01-01

    Resumen Este estudio tuvo como objetivo investigar la asociación entre intereses profesionales y valores de trabajo, y entre valores de trabajo y rasgos de personalidad. Participaron 281 universitarios, con edad media de 23.97 años, de los cursos de Administración, Psicología, Filosofía y Teología, del Estado de San Pablo, Brasil. Fueron aplicados tres instrumentos (Escala de Evaluación de los Valores de Trabajo, Cuestionario de Búsqueda Auto-Dirigida y Batería Factorial de Personalidad). Los...

  2. Elementos cognitivos para el análisis ergonómico del trabajo

    OpenAIRE

    Castillo-Martínez, Juan A; Universidad del Rosario, Escuela de Medicina y Ciencias de la Salud. Grupo de Investigación Salud Cognición y Trabajo

    2007-01-01

    Esta nota de investigación presenta algunos de los elementos de base para el análisis de la actividad del trabajo desde la perspectiva de la ergonomía cognitiva. Para poder aproximarse a la relación existente entre los procesos cognitivos en el trabajo y la noción de ergonomía es necesario abordar inicialmente la definición de esta disciplina. El termino ergonomía, acuñado en 1940 por el psicólogo británico Hywel Murrell, (del Griego ergo: trabajo + nomos: ley, conocimiento)...

  3. Mujeres receptoras de remesas y trabajo no remunerado en el Ecuador

    OpenAIRE

    Tello Torres, Nanci Leonor

    2010-01-01

    En el Ecuador las mujeres son protagonistas de dos aspectos importantes, las que destinan mayor carga global de trabajo respecto de los hombres, especialmente el trabajo no remunerado o doméstico; y las mayores receptoras de remesas de los emigrantes que están fuera del país y por ende administradoras de estos recursos. El resultado más importante de este estudio fue constatar que las mujeres, aumentaron su carga de trabajo no remunerado por los compromisos que adquieren con los familiares m...

  4. Capitalismo cognitivo, trabajo informacional y un poco de música

    Directory of Open Access Journals (Sweden)

    Mariano Zukerfeld

    2008-01-01

    Full Text Available Este artículo está organizado en torno a tres secciones. En la primera, se presenta un resumen de nuestro marco teórico para pensar el capitalismo cognitivo, centrado en el concepto de bienes informacionales. En la segunda, utilizando los datos de un estudio de campo, se aplican las categorías esbozadas para caracterizar algunos aspectos del trabajo de los músicos en la actualidad. Finalmente, se extienden las ideas surgidas de la sección anterior y se propone la noción de trabajo informacional para pensar la forma de trabajo que distingue a la presente etapa.

  5. Capitalismo cognitivo, trabajo informacional y un poco de música

    Directory of Open Access Journals (Sweden)

    Mariano Zukerfeld

    2008-04-01

    Full Text Available Este artículo está organizado en torno a tres secciones. En la primera, se presenta un resumen de nuestro marco teórico para pensar el capitalismo cognitivo, centrado en el concepto de bienes informacionales. En la segunda, utilizando los datos de un estudio de campo, se aplican las categorías esbozadas para caracterizar algunos aspectos del trabajo de los músicos en la actualidad. Finalmente, se extienden las ideas surgidas de la sección anterior y se propone la noción de trabajo informacional para pensar la forma de trabajo que distingue a la presente etapa.

  6. Claves para la Gestión de Puestos de Trabajo en las Organizaciones en Red.

    OpenAIRE

    Moreno Romero, Ana María; Mataix Aldeanueva, Carlos; Mahou Fernández, Ángel

    2011-01-01

    Las organizaciones viven cambios estratégicos, culturales y organizativos para adaptarse a la sociedad red. La incorporación de las Tecnologías de Información y Comunicación facilita los esquemas de trabajo en red dentro de las organizaciones y entre ellas. En este contexto, hay profesionales desbordados en su puesto de trabajo, por exceso de información, correos electrónicos, llamadas, reuniones, plataformas virtuales. Estos cambios suponen un reto para la organización del trabajo y mejora d...

  7. Trabajo y Moralidad en las relaciones de producción capitalistas

    OpenAIRE

    ASSUSA,GONZALO

    2014-01-01

    El Trabajo como praxis ha sido ubicado, en el contexto de la modernidad, en la esfera de “lo económico”, pero los discursos que lo construyen como problema tienden a revestirlo con una serie de elementos normativos y valoraciones que no se condicen con las condiciones estructurales y las “reglas de juego” propias del mercado de trabajo del sistema capitalista. Reconstruiremos aquí algunos núcleos teóricos de abordaje de la relación entre Trabajo y Cultura en términos de Moral en el marco de u...

  8. Condiciones de trabajo psicosociales y desgaste psíquico en trabajadores de diversos sectores empresariales de Centro-Oriente, Suroccidente y región Caribe en Colombia

    Directory of Open Access Journals (Sweden)

    M. Ángeles Carrión García

    2014-01-01

    Full Text Available Objetivo: Determinar la percepción de trabajadores de distintos sectores empresariales de Colombia sobre los factores psicosociales presentes en su entorno laboral y la relación entre los factores psicosociales nocivos y los síntomas subjetivos y alteraciones de la salud. Materiales y métodos: Estudio no experimental, transversal y cuantitativo. Participaron 370 trabajadores, de diferentes sectores empresariales de Colombia (Centro-Oriente, Suroccidente y región Caribe. Instrumento: batería para el estudio de las condiciones de trabajo de carácter psicosocial (CTCPS-MAC, validada para población iberoamericana, permite evaluar cuatro dimensiones: Contexto de trabajo, Contenido de trabajo, Factores individuales y Desgaste psíquico e incluye catorce factores psicosociales. Los datos se analizaron con IBM SPSS statistics 21. Se realizó análisis bivariado y regresión logística multivariante de factores psicosociales nocivos y desgaste psíquico. Resultados: Los factores formación, baja médica, contexto de trabajo, contenido de trabajo y factores individuales están asociados en este estudio con desgaste psíquico. El contexto de trabajo es la variable que infiere mayor riesgo (p=0.000; Exp (B= 5.355 para provocar desgaste psíquico, seguida de la formación técnica o superior y del contenido del trabajo. Conclusiones: Si bien aquellos trabajadores cuya percepción nociva del contexto de trabajo (interrelación trabajo-vida familiar/personal, cultura de la organización, gestión de la empresa, etc., del contenido de trabajo (concepción tareas, carga y ritmo de trabajo, etc. y los que tienen formación técnica o superior tienen mayor probabilidad de padecer desgaste psíquico, se observan aspectos positivos de las condiciones de trabajo psicosocial y su influencia en los trabajadores y en las organizaciones.

  9. Current Strategies for Quantitating Fibrosis in Liver Biopsy

    Directory of Open Access Journals (Sweden)

    Yan Wang

    2015-01-01

    Full Text Available Objective: The present mini-review updated the progress in methodologies based on using liver biopsy. Data Sources: Articles for study of liver fibrosis, liver biopsy or fibrosis assessment published on high impact peer review journals from 1980 to 2014. Study Selection: Key articles were selected mainly according to their levels of relevance to this topic and citations. Results: With the recently mounting progress in chronic liver disease therapeutics, comes by a pressing need for precise, accurate, and dynamic assessment of hepatic fibrosis and cirrhosis in individual patients. Histopathological information is recognized as the most valuable data for fibrosis assessment. Conventional histology categorical systems describe the changes of fibrosis patterns in liver tissue; but the simplified ordinal digits assigned by these systems cannot reflect the fibrosis dynamics with sufficient precision and reproducibility. Morphometric assessment by computer assist digital image analysis, such as collagen proportionate area (CPA, detects change of fibrosis amount in tissue section in a continuous variable, and has shown its independent diagnostic value for assessment of advanced or late-stage of fibrosis. Due to its evident sensitivity to sampling variances, morphometric measurement is feasible to be taken as a reliable statistical parameter for the study of a large cohort. Combining state-of-art imaging technology and fundamental principle in Tissue Engineering, structure-based quantitation was recently initiated with a novel proof-of-concept tool, qFibrosis. qFibrosis showed not only the superior performance to CPA in accurately and reproducibly differentiating adjacent stages of fibrosis, but also the possibility for facilitating analysis of fibrotic regression and cirrhosis sub-staging. Conclusions: With input from multidisciplinary innovation, liver biopsy assessment as a new "gold standard" is anticipated to substantially support the accelerated

  10. The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis

    Directory of Open Access Journals (Sweden)

    Lucy A. Murtha

    2017-10-01

    Full Text Available Fibrosis is the formation of fibrous connective tissue in response to injury. It is characterized by the accumulation of extracellular matrix components, particularly collagen, at the site of injury. Fibrosis is an adaptive response that is a vital component of wound healing and tissue repair. However, its continued activation is highly detrimental and a common final pathway of numerous disease states including cardiovascular and respiratory disease. Worldwide, fibrotic diseases cause over 800,000 deaths per year, accounting for ~45% of total deaths. With an aging population, the incidence of fibrotic disease and subsequently the number of fibrosis-related deaths will rise further. Although, fibrosis is a well-recognized cause of morbidity and mortality in a range of disease states, there are currently no viable therapies to reverse the effects of chronic fibrosis. Numerous predisposing factors contribute to the development of fibrosis. Biological aging in particular, interferes with repair of damaged tissue, accelerating the transition to pathological remodeling, rather than a process of resolution and regeneration. When fibrosis progresses in an uncontrolled manner, it results in the irreversible stiffening of the affected tissue, which can lead to organ malfunction and death. Further investigation into the mechanisms of fibrosis is necessary to elucidate novel, much needed, therapeutic targets. Fibrosis of the heart and lung make up a significant proportion of fibrosis-related deaths. It has long been established that the heart and lung are functionally and geographically linked when it comes to health and disease, and thus exploring the processes and mechanisms that contribute to fibrosis of each organ, the focus of this review, may help to highlight potential avenues of therapeutic investigation.

  11. Fibrosis of Two: Epithelial Cell-Fibroblast Interactions in Pulmonary Fibrosis

    Science.gov (United States)

    Sakai, Norihiko; Tager, Andrew M.

    2013-01-01

    Idiopathic pulmonary fibrosis (IPF) is characterized by the progressive and ultimately fatal accumulation of fibroblasts and extracellular matrix in the lung that distorts its architecture and compromises its function. IPF is now thought to result from wound-healing processes that, although initiated to protect the host from injurious environmental stimuli, lead to pathological fibrosis due to these processes becoming aberrant or over-exuberant. Although the environmental stimuli that trigger IPF remain to be identified, recent evidence suggests that they initially injure the alveolar epithelium. Repetitive cycles of epithelial injury and resultant alveolar epithelial cell death provoke the migration, proliferation, activation and myofibroblast differentiation of fibroblasts, causing the accumulation of these cells and the extracellular matrix that they synthesize. In turn, these activated fibroblasts induce further alveolar epithelial cell injury and death, thereby creating a vicious cycle of pro-fibrotic epithelial cell-fibroblast interactions. Though other cell types certainly make important contributions, we focus here on the “pas de deux” (steps of two), or perhaps more appropriate to IPF pathogenesis, the “folie à deux” (madness of two) of epithelial cells and fibroblasts that drives the progression of pulmonary fibrosis. We describe the signaling molecules that mediate the interactions of these cell types in their “fibrosis of two”, including transforming growth factor-β, connective tissue growth factor, sonic hedgehog, prostaglandin E2, angiotensin II and reactive oxygen species. PMID:23499992

  12. Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients

    DEFF Research Database (Denmark)

    Fluge, Gjermund; Olesen, Hanne Vebert; Giljam, Marita

    2009-01-01

    Background: The co-morbidity of cystic fibrosis (CF) and celiac disease (CD) has been reported sporadically since the 1960s. To our knowledge, this is the first time a systematic screening is performed in a large cohort of CF patients. Methods: Transglutaminase-IgA (TGA), endomysium-IgA (EMA...

  13. Idiopathic Pulmonary Fibrosis: The Association between the Adaptive Multiple Features Method and Fibrosis Outcomes.

    Science.gov (United States)

    Salisbury, Margaret L; Lynch, David A; van Beek, Edwin J R; Kazerooni, Ella A; Guo, Junfeng; Xia, Meng; Murray, Susan; Anstrom, Kevin J; Yow, Eric; Martinez, Fernando J; Hoffman, Eric A; Flaherty, Kevin R

    2017-04-01

    Adaptive multiple features method (AMFM) lung texture analysis software recognizes high-resolution computed tomography (HRCT) patterns. To evaluate AMFM and visual quantification of HRCT patterns and their relationship with disease progression in idiopathic pulmonary fibrosis. Patients with idiopathic pulmonary fibrosis in a clinical trial of prednisone, azathioprine, and N-acetylcysteine underwent HRCT at study start and finish. Proportion of lung occupied by ground glass, ground glass-reticular (GGR), honeycombing, emphysema, and normal lung densities were measured by AMFM and three radiologists, documenting baseline disease extent and postbaseline change. Disease progression includes composite mortality, hospitalization, and 10% FVC decline. Agreement between visual and AMFM measurements was moderate for GGR (Pearson's correlation r = 0.60, P fibrosis (as measured by GGR densities) is independently associated with elevated hazard for disease progression. Postbaseline change in AMFM-measured and visually measured GGR densities are modestly correlated with change in FVC. AMFM-measured fibrosis is an automated adjunct to existing prognostic markers and may allow for study enrichment with subjects at increased disease progression risk.

  14. El mobbing o acoso moral en el trabajo Un enfoque jurídico

    Directory of Open Access Journals (Sweden)

    Graciela Giuzio

    2014-01-01

    Full Text Available Puede decirse a grandes rasgos que el mobbing consiste en una degradación del ambiente de trabajo ,causado por conductas abusivas de los superiores jerárquicos respecto de sus subordinados (acoso vertical o bossing; o entre compañeros de trabajo (acoso horizontal o entre iguales;o provenientes de los que ocupan puestos subordinados respecto de sus jefes . Ello vuelve extremadamente penoso para el trabajador el continuar la relación laboral, lesiona entre otros derechos la dignidad personal y termina alterando con frecuencia su salud física y mental.La violencia en el trabajo. En qué consiste el acoso moral en el trabajo. Tipología del acoso moral. Concepto jurídico de mobbing. Elementos típicos y accesorios. Acoso moral en Uruguay. Prevención del acoso. Conclusiones

  15. y la Condición Laboral con el Significado del Trabajo

    Directory of Open Access Journals (Sweden)

    Silvana Dakduk

    2008-01-01

    Full Text Available La investigación tuvo como propósito examinar las relaciones entre patrón de conducta, locus de control, nivel socioeconómico, nivel educativo, sexo, condición laboral con los componentes del significado del trabajo. La muestra fue de 300 personas con edades entre 20-40 años. Se encontró que los empleados otorgan gran importancia al trabajo en su vida. Pero es la familia la que ocupa el primer lugar. El resultado más valorado del trabajo son los ingresos obtenidos. Son los empleados informales los que atribuyen mayor importancia a ésta característica del trabajo. Los empleados alternativos y formales dan mayor importancia a la oportunidad de aprender cosas nuevas, estabilidad en el empleo y buenas condiciones físicas.

  16. Machine-learning-based classification of real-time tissue elastography for hepatic fibrosis in patients with chronic hepatitis B.

    Science.gov (United States)

    Chen, Yang; Luo, Yan; Huang, Wei; Hu, Die; Zheng, Rong-Qin; Cong, Shu-Zhen; Meng, Fan-Kun; Yang, Hong; Lin, Hong-Jun; Sun, Yan; Wang, Xiu-Yan; Wu, Tao; Ren, Jie; Pei, Shu-Fang; Zheng, Ying; He, Yun; Hu, Yu; Yang, Na; Yan, Hongmei

    2017-10-01

    Hepatic fibrosis is a common middle stage of the pathological processes of chronic liver diseases. Clinical intervention during the early stages of hepatic fibrosis can slow the development of liver cirrhosis and reduce the risk of developing liver cancer. Performing a liver biopsy, the gold standard for viral liver disease management, has drawbacks such as invasiveness and a relatively high sampling error rate. Real-time tissue elastography (RTE), one of the most recently developed technologies, might be promising imaging technology because it is both noninvasive and provides accurate assessments of hepatic fibrosis. However, determining the stage of liver fibrosis from RTE images in a clinic is a challenging task. In this study, in contrast to the previous liver fibrosis index (LFI) method, which predicts the stage of diagnosis using RTE images and multiple regression analysis, we employed four classical classifiers (i.e., Support Vector Machine, Naïve Bayes, Random Forest and K-Nearest Neighbor) to build a decision-support system to improve the hepatitis B stage diagnosis performance. Eleven RTE image features were obtained from 513 subjects who underwent liver biopsies in this multicenter collaborative research. The experimental results showed that the adopted classifiers significantly outperformed the LFI method and that the Random Forest(RF) classifier provided the highest average accuracy among the four machine algorithms. This result suggests that sophisticated machine-learning methods can be powerful tools for evaluating the stage of hepatic fibrosis and show promise for clinical applications. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Protective role of NKT cells and macrophage M2-driven phenotype in bleomycin-induced pulmonary fibrosis.

    Science.gov (United States)

    Grabarz, Felipe; Aguiar, Cristhiane Favero; Correa-Costa, Matheus; Braga, Tárcio Teodoro; Hyane, Meire I; Andrade-Oliveira, Vinícius; Landgraf, Maristella Almeida; Câmara, Niels Olsen Saraiva

    2018-04-01

    Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells are a major source of Th1 and Th2 cytokines and may be crucial in the polarization of M1/M2 macrophages in pulmonary fibrogenesis. Although there appears to be constant scientific progress in that field, pulmonary fibrosis still exhibits no current cure. From these facts, we hypothesized that NKT cells could influence the development of pulmonary fibrosis via modulation of macrophage activation. Wild type (WT) and NKT type I cell-deficient mice (Jα18 -/- ) were subjected to the protocol of bleomycin-induced pulmonary fibrosis with or without treatment with NKT cell agonists α-galactosylceramide and sulfatide. The participation of different cell populations, collagen deposition, and protein levels of different cytokines involved in inflammation and fibrosis was evaluated. The results indicate a benign role of NKT cells in Jα18 -/- mice and in wild-type α-galactosylceramide-sulfatide-treated groups. These animals presented lower levels of collagen deposition, fibrogenic molecules such as TGF-β and vimentin and improved survival rates. In contrast, WT mice developed a Th2-driven response augmenting IL-4, 5, and 13 protein synthesis and increased collagen deposition. Furthermore, the arginase-1 metabolic pathway was downregulated in wild-type NKT-activated and knockout mice indicating lower activity of M2 macrophages in lung tissue. Hence, our data suggest that NKT cells play a protective role in this experimental model by down modulating the Th2 milieu, inhibiting M2 polarization and finally preventing fibrosis.

  18. Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis.

    Directory of Open Access Journals (Sweden)

    Eric Lefebvre

    Full Text Available Interactions between C-C chemokine receptor types 2 (CCR2 and 5 (CCR5 and their ligands, including CCL2 and CCL5, mediate fibrogenesis by promoting monocyte/macrophage recruitment and tissue infiltration, as well as hepatic stellate cell activation. Cenicriviroc (CVC is an oral, dual CCR2/CCR5 antagonist with nanomolar potency against both receptors. CVC's anti-inflammatory and antifibrotic effects were evaluated in a range of preclinical models of inflammation and fibrosis.Monocyte/macrophage recruitment was assessed in vivo in a mouse model of thioglycollate-induced peritonitis. CCL2-induced chemotaxis was evaluated ex vivo on mouse monocytes. CVC's antifibrotic effects were evaluated in a thioacetamide-induced rat model of liver fibrosis and mouse models of diet-induced non-alcoholic steatohepatitis (NASH and renal fibrosis. Study assessments included body and liver/kidney weight, liver function test, liver/kidney morphology and collagen deposition, fibrogenic gene and protein expression, and pharmacokinetic analyses.CVC significantly reduced monocyte/macrophage recruitment in vivo at doses ≥20 mg/kg/day (p < 0.05. At these doses, CVC showed antifibrotic effects, with significant reductions in collagen deposition (p < 0.05, and collagen type 1 protein and mRNA expression across the three animal models of fibrosis. In the NASH model, CVC significantly reduced the non-alcoholic fatty liver disease activity score (p < 0.05 vs. controls. CVC treatment had no notable effect on body or liver/kidney weight.CVC displayed potent anti-inflammatory and antifibrotic activity in a range of animal fibrosis models, supporting human testing for fibrotic diseases. Further experimental studies are needed to clarify the underlying mechanisms of CVC's antifibrotic effects. A Phase 2b study in adults with NASH and liver fibrosis is fully enrolled (CENTAUR Study 652-2-203; NCT02217475.

  19. Identidades de Trabajo Social: interrogaciones desde las historias de configuración profesional

    OpenAIRE

    Lera, Carmen Inés; Ludi, María del Carmen; Bugdhal, Susana; Angeramo, Luciana

    2016-01-01

    Este trabajo toma aspectos del Proyecto de Investigación: “Identidad profesional de Trabajo Social. Principales rasgos de su configuración en distintos actores del campo profesional”. Partimos de entender a la identidad como devenir, como movimiento, alejada de esencialismos. Consecuentemente ello nos habilita a constituir-nos en actores que deliberadamente propiciamos alteraciones sobre aquellas dimensiones que cuestionamos, siendo muchas de ellas dominantes. Aquí radica la potencia de pe...

  20. Actitudes y engagement en el trabajo como antecedentes del comportamiento altruista

    OpenAIRE

    Dolores Álvarez Pérez; Carmen Castro Casal; Guadalupe Vila Vázquez

    2014-01-01

    El reconocimiento de que el comportamiento altruista genera beneficios tanto para los empleados como para la organización hace necesario comprender los factores que pueden alentarlo. Por ello, este trabajo persigue dos objetivos: a) analizar las relaciones entre la satisfacción general con el puesto y el compromiso afectivo con el comportamiento altruista y b) explorar si elengagement en el trabajo aumenta la varianza explicada en el altruismo por encima de tales actitudes. Para cumplir estos...

  1. Conflicto trabajo-familia, en mujeres profesionales que trabajan en la modalidad de empleo

    Directory of Open Access Journals (Sweden)

    Adaneys Álvarez R.

    2011-01-01

    Full Text Available Objetivo. La investigación tuvo como objetivo establecer indicadores del conflicto trabajo-familia desde la perspectiva de rol y sus implicaciones psicosociales, en mujeres profesionales en la modalidad de empleo. Método. Estudio de tipo descriptivo-cualitativo. Las participantes, cinco, mujeres profesionales que trabajaran en la modalidad de empleo, entre 25 y 50 años de edad, convivieran con su pareja y tuvieran hijos entre 0 y 11 años de edad. Se utilizó el análisis de contenido para analizar la información recogida a través de la entrevista estructurada con preguntas abiertas. Resultados. Se encontró que la sobrecarga de rol -tanto en lo laboral como en lo familiar- afecta a las mujeres como antecedente del conflicto trabajo-familia, lo cual se explica por las condiciones laborales (carga de trabajo y formas de contratación y la doble jornada de trabajo. Otros factores que explican el conflicto trabajo-familia son el conflicto y la ambigüedad de rol. Con respecto a las implicaciones psicosociales, se encontró que la salud se ve afectada por cambios en el estado de ánimo y cansancio físico. Se halló; como factores protectores que ayudan a las mujeres a disminuir la presencia del conflicto trabajo-familia, el apoyo social (doméstico y de pareja y los recursos internos (la toma de decisiones y el establecimiento de prioridades. Conclusiones. La incorporación de la mujer al mercado de trabajo ha tenido repercusiones en la estructura familiar; se requiere que los diferentes estamentos planteen estrategias que permitan conciliar la interfase de la relación trabajo familia.

  2. Microbiological surveillance in patients with cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Paola Gualdi

    2010-06-01

    Full Text Available Pulmonary infections in patients with cystic fibrosis (CF, are a major cause of morbidity and mortality. Prevention, diagnosis and therapy in cystic fibrosis, lead to the necessary collaboration between clinical and laboratory to identify effective strategies and appropriate solutions to address the problems inherent isolation micro-organisms, antibiotic strategies, overcoming of bacterial resistance and other problems management of these patients. The task of the microbiology laboratory and research in quickly and accurately, the agents responsible for these infectious processes, in order to isolate them from material, identify and determine their sensitivity antibiotics. A microbiological surveillance on 34 patients (13 males and 21 females with CF and related to the “Support Services Provincial Trento for the treatment of cystic fibrosis “in the period July 2005 - August 2008, was carried out. 180 Gram positive and 278 of Gram negative bacteria as well as 235 fungi wre collected. Staphylococcus aureus was the most frequently organism found in patients with CF with an incidence of 23% on 156 strains isolated, Pseudomonas aeruginosa was collected 19% of all microorganisms isolated corresponding to 131 strains, Candida albicans is the yeast often isolated with a frequency 22% equal to 149 isolates, Aspergillus fumigatus was isolated at a rate of 8%. From the data we collected and processed has been noted that the local epidemiology of CF patients reflects as reported in the scientific literature and national international consulting, both as a type microorganisms that frequency also isolated compared to age groups. Considering the score of Bartlett as discriminating respiratory fitness of the material, it has been observed that only 32 samples over 327 total (10% would materials insignificant. It follows therefore that the time of sample collection, followed by personnel (physiotherapists dedicated to CF patients, represents a crucial step

  3. The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis

    NARCIS (Netherlands)

    Murtha, Lucy A.; Schuliga, Michael J.; Mabotuwana, Nishani S.; Hardy, Sean A.; Waters, David W.; Burgess, Janette K.; Knight, Darryl A.; Boyle, Andrew J.

    2017-01-01

    Fibrosis is the formation of fibrous connective tissue in response to injury. It is characterized by the accumulation of extracellular matrix components, particularly collagen, at the site of injury. Fibrosis is an adaptive response that is a vital component of wound healing and tissue repair.

  4. Intracerebral abscess: A complication of severe cystic fibrosis lung disease

    OpenAIRE

    Fenton, Mark E; Cockcroft, Donald W; Gjevre, John A

    2008-01-01

    Intracerebral abscess is an uncommon complication of severe cystic fibrosis lung disease. The present report describes a case of fatal multiple intracerebral abscesses in a patient with a severely bronchiectatic, nonfunctioning right lung and chronic low-grade infection. The patient was previously turned down for pneumonectomy. Intracerebral abscess in cystic fibrosis and the potential role of pneumonectomy in the present patient are discussed.

  5. Addressing liver fibrosis with Liposomes targeted to hepatic stellate cells

    NARCIS (Netherlands)

    Adrian, Joanna E.; Poelstra, Klaas; Kamps, Jan A. A. M.

    2007-01-01

    Liver fibrosis is a chronic disease that results from hepatitis B and C infections, alcohol abuse or metabolic and genetic disorders. Ultimately, progression of fibrosis leads to cirrhosis, a stage of the disease characterized by failure of the normal liver functions. Currently, the treatment of

  6. Increased alveolar soluble Annexin V promotes lung inflammation and fibrosis

    OpenAIRE

    Buckley, S.; Shi, W.; Xu, W.; Frey, M.R.; Moats, R.; Pardo, A.; Selman, M.; Warburton, D.

    2015-01-01

    The causes underlying the self-perpetuating nature of idiopathic pulmonary fibrosis (IPF), a progressive and usually lethal disease, remain unknown. We hypothesized that alveolar soluble Annexin V contributes to lung fibrosis, based on the observation that human IPF BALF containing high Annexin V levels promoted fibroblast involvement in alveolar epithelial wound healing that was reduced when Annexin V was depleted from the BALF.

  7. Pancreatic fibrosis correlates with exocrine pancreatic insufficiency after pancreatoduodenectomy

    NARCIS (Netherlands)

    T.C. Tran; G. van 't Hof; G. Kazemier (Geert); W.C.J. Hop (Wim); C.J. Pek (Chulja); A.W. van Toorenenbergen (Albert); H. van Dekken (Herman); C.H.J. van Eijck (Casper)

    2008-01-01

    textabstractBackground: Obstruction of the pancreatic duct can lead to pancreatic fibrosis. We investigated the correlation between the extent of pancreatic fibrosis and the postoperative exocrine and endocrine pancreatic function. Methods: Fifty-five patients who were treated for pancreatic and

  8. Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats

    Directory of Open Access Journals (Sweden)

    Lili eGao

    2015-10-01

    Full Text Available Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that lacks effective therapies at present. Glycyrrhizic acid (GA, a natural compound extracted from a traditional Chinese herbal medicine Glycyrrhiza glabra, was recently reported to benefit lung injury and liver fibrosis in animal models, yet whether GA has a therapeutic effect on pulmonary fibrosis is unknown. In this study, we investigated the potential therapeutic effect of GA on pulmonary fibrosis in a rat model with bleomycin (BLM-induced pulmonary fibrosis. The results indicated that GA treatment remarkably ameliorated BLM-induced pulmonary fibrosis and attenuated BLM-induced inflammation, oxidative stress, epithelial-mesenchymal transition and activation of tansforming growth factor-beta signaling pathway in the lungs. Further, we demonstrated that GA treatment inhibited proliferation of 3T6 fibroblast cells, induced cell cycle arrest and promoted apoptosis in vitro, implying that GA-mediated suppression of fibroproliferation may contribute to the anti-fibrotic effect against BLM-induced pulmonary fibrosis. In summary, our study suggests a therapeutic potential of GA in the treatment of pulmonary fibrosis.

  9. Nephrogenic systemic fibrosis (NSF) and gadolinium-based contrast ...

    African Journals Online (AJOL)

    Nephrogenic systemic fibrosis (NSF), unknown before March 1997 and first described in 2000, is a systemic disorder characterised by widespread tissue fibrosis. The first known case occurred in 1997, after the use of gadolinium-based contrast agents (GBCAs) at high doses in patients with renal failure had become routine.

  10. Vitamin K supplementation for cystic fibrosis.

    Science.gov (United States)

    Jagannath, Vanitha A; Thaker, Vidhu; Chang, Anne B; Price, Amy I

    2017-08-22

    Cystic fibrosis is a genetic disorder which can lead to multiorgan dysfunction. Malabsorption of fat and fat-soluble vitamins (A, D, E, K) may occur and can cause subclinical deficiencies of some of these vitamins. Vitamin K is known to play an important role in both blood coagulation and bone formation. Supplementation with vitamin K appears to be one way of addressing the deficiency, but there is very limited agreement on the appropriate dose and frequency of use of these supplements. This is an updated version of the review. To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Most recent search: 30 January 2017. Randomised and quasi-randomised controlled trials of all preparations of vitamin K used as a supplement compared to either no supplementation (or placebo) at any dose or route and for any duration, in children or adults diagnosed with cystic fibrosis (by sweat test or genetic testing). Two authors independently screened papers, extracted trial details and assessed their risk of bias. Two trials (total of 32 participants) each lasting one month were included in the review and were assessed as having a moderate risk of bias. One was a dose-ranging parallel group trial in children (aged 8 to 18 years); and the other (with an older cohort) had a cross-over design comparing supplements to no treatment, but no separate data were reported for the first intervention period. Neither of the trials addressed any of the primary outcomes (coagulation, bone formation and quality of life). Both trials reported the restoration of serum vitamin K and undercarboxylated osteocalcin

  11. CYSTIC FIBROSIS: MICROBIOLOGY AND HOST RESPONSE

    Science.gov (United States)

    Zemanick, Edith T.

    2016-01-01

    THE EARLIEST DESCRIPTIONS OF LUNG DISEASE IN PEOPLE WITH CYSTIC FIBROSIS (CF) DEMONSTRATED THE INVOLVEMENT OF THREE INTERACTING PATHOPHYSIOLOGICAL ELEMENTS IN CF AIRWAYS: MUCUS OBSTRUCTION, INFLAMMATION, AND INFECTION. OVER THE PAST 7 DECADES, OUR UNDERSTANDING OF CF RESPIRATORY MICROBIOLOGY AND INFLAMMATION HAS EVOLVED WITH THE INTRODUCTION OF NEW TREATMENTS, WITH INCREASED LONGEVITY, AND WITH INCREASINGLY SOPHISTICATED LABORATORY TECHNIQUES. IN THIS CHAPTER, WE WILL REVIEW THE CURRENT STATE OF UNDERSTANDING OF THE ROLES OF INFECTION AND INFLAMMATION AND THEIR ROLES IN DRIVING LUNG DISEASE. WE WILL ALSO DISCUSS HOW THIS CONSTANTLY EVOLVING INFORMATION IS USED TO INFORM CURRENT THERAPEUTIC STRATEGIES, MEASURES AND PREDICTORS OF DISEASE SEVERITY, AND RESEARCH PRIORITIES. PMID:27469179

  12. Nephrogenic systemic fibrosis: A brief review

    Directory of Open Access Journals (Sweden)

    Rajesh Waikhom

    2011-01-01

    Full Text Available Nephrogenic systemic fibrosis is a fibrosing disorder of the skin that develops in patients with advanced renal failure. It mostly presents with progressive hardening or induration of the skin of the extremities. Systemic involvement is also known to occur in this entity. Exposure to gadolinium contrast for radiological evaluation has been identified as the offending agent. The condition is progressive and can be seriously disabling. Therapeutic options are limited and not rewarding in majority of the cases. Awareness of this entity is important so that proper precautionary measures can be taken at the earliest to ameliorate the condition.

  13. Patient-reported Outcomes in Cystic Fibrosis

    OpenAIRE

    Goss, Christopher H.; Quittner, Alexandra L.

    2007-01-01

    Over the past 20 years, there has been tremendous progress in the area of patient-reported outcomes (PROs). A PRO instrument is defined as any measure of a patient's health status that is elicited directly from the patient and assesses how the patient “feels or functions with respect to his or her health condition.” The advances seen in clinical research regarding PROs has been mirrored in research in cystic fibrosis (CF). A large number of instruments have been used for both therapeutic and ...

  14. Is nintedanib effective for idiopathic pulmonary fibrosis?

    OpenAIRE

    Alejandro Jeldres

    2017-01-01

    Resumen La fibrosis pulmonar idiopática es una enfermedad de mal pronóstico y cuyas terapias efectivas son escasas. En la búsqueda de tratamientos que puedan modificar el curso de la enfermedad ha surgido como una alternativa el nintedanib (BIBF 1120), un inhibidor de tirosina kinasa. Sin embargo, su rol aún no está claro. Para responder esta pregunta utilizamos la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en múltiples fuentes de información. Identificamos siete ...

  15. Is pirfenidone effective for idiopathic pulmonary fibrosis?

    OpenAIRE

    Alejandro Jeldres; Gonzalo Labarca

    2017-01-01

    Resumen Se ha planteado que la pirfenidona, un agente antifibrótico, podría cambiar el curso de la fibrosis pulmonar idiopática, una enfermedad de pronóstico ominoso y para la cual prácticamente no existen terapias efectivas. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en múltiples bases de datos, identificamos trece revisiones sistemáticas que en conjunto incluyen nueve estudios primarios, siete de los cuales son aleatorizados y cuyos resultados se a...

  16. FIBROSIS PROGRESIVA DEL CUÁDRICEPS

    Directory of Open Access Journals (Sweden)

    Enrique Vergara Amador

    2011-04-01

    Discusión. El vasto intermedio ha sido utilizado para aplicación de medicamentos. Se tiene evidencia que esta porción muscular tiene una pobre perfusión sanguínea en niños. No se conoce aún exactamente la fisiopatología de la fibrosis. Muchos niños son mal diagnosticados, confundiéndolos con patologías articulares y reciben equivocadamente otros tipos de cirugías.

  17. Prenatal intestinal volvulus: look for cystic fibrosis.

    Science.gov (United States)

    Chouikh, Taieb; Mottet, Nicolas; Cabrol, Christelle; Chaussy, Yann

    2016-12-21

    Intestinal volvulus is a life-threatening emergency requiring prompt surgical management. Prenatal intestinal volvulus is rare, and most are secondary to intestinal atresia, mesenteric defect or without any underlying cause. Cystic fibrosis (CF) is known to cause digestive tract disorders. After birth, 10-15% of newborns with CF may develop intestinal obstruction within a few days of birth because of meconial ileus. 1 This obstruction is a result of dehydrated thickened meconium obstructing the intestinal lumen. We report two cases of fetuses with prenatal diagnosis of segmental volvulus in whom CF was diagnosed. 2016 BMJ Publishing Group Ltd.

  18. Los roles no laborales y el estrés en el trabajo.

    Directory of Open Access Journals (Sweden)

    Juan Guerrero

    2003-01-01

    Full Text Available Este análisis se ocupa de dimensiones esenciales de las personas vinculadas al mundo del trabajo: el “momento de trabajo” y el “momento de no-trabajo”. Se cotejan relaciones y procesos invariablemente presentes en el diario vivir de hombres y mujeres, pero que afectan su bienestar y desempeño ocupacional de manera distinta. Se trata de aspectos que convergen y se potencian para dar lugar a variados perfiles de vida laboral y extralaboral, a diferentes perfiles de salud y productividad. Estos son entre otros: los conocimientos y habilidades del individuo, sus condiciones de genero, sus expectativas ocupacionales, su estilo de vida, sus valores y patrones de crianza, su vulnerabilidad al estrés, sus estrategias de afrontamiento, las oportunidades de empleo, la diversidad de roles, el tiempo disponible para atenderlos, la naturaleza y disponibilidad de apoyo social. El concepto que orienta todo el análisis es el de “spillover” trabajo-familia, que corresponde a la permanente e inevitable “contaminación psicológica” de las circunstancias del trabajo sobre la vida familiar y viceversa. Se trata de un proceso connatural a la existencia de hombres y mujeres de la sociedad industrial y que invariablemente está presente para enriquecer o empobrecer el desempeño humano en, dentro o fuera del trabajo

  19. Efecto del burnout y la sobrecarga en la calidad de vida en el trabajo

    Directory of Open Access Journals (Sweden)

    Juana Patlán Pérez

    2013-01-01

    Full Text Available El síndrome de burnout se presenta con frecuencia en trabajadores que tienen contacto con usuarios o clientes. El artículo tiene como objetivo determinar el efecto del burnout y la sobrecarga en la calidad de vida en el trabajo en personal de un instituto de salud en México. La metodología de investigación fue expostfacto y descriptiva con una muestra estratificada de 673 trabajadores. Se utilizaron 4 escalas para medir sobrecarga de trabajo, burnout y 2 factores de calidad de vida en el trabajo: conflicto trabajo-familia y satisfacción laboral. Los resultados indican un efecto positivo y significativo de la sobrecarga en el burnout y el conflicto trabajo-familia, y un efecto negativo de la sobrecarga en la satisfacción laboral. Además, el burnout está asociado de forma positiva al conflicto trabajo-familia y negativa a la satisfacción laboral.

  20. Determinantes del trabajo infantil y la escolaridad: el caso del Valle del Cauca en Colombia

    Directory of Open Access Journals (Sweden)

    Sebastián Urueña Abadía

    2009-10-01

    Full Text Available Colombia, al igual que la mayoría de países latinoamericanos, consciente de las repercusiones sociales y económicas negativas del trabajo infantil, se ha comprometido en la lucha por la erradicación de este fenómeno. Prueba de ello es la ratificación por parte del gobierno colombiano en el año 2007, del Convenio 182 de la OIT sobre la Prohibición de las Peores Formas de Trabajo Infantil y la Acción Inmediata para su Eliminación. En el plano regional, como parte del Plan de Desarrollo del Departamento del Valle del Cauca 2008-2011, se está implementando actualmente una estrategia territorial de erradicación del trabajo infantil en sus 42 municipios. Considerando este panorama, este trabajo indaga cuáles son los determinantes del trabajo infantil y la escolaridad en el departamento del Valle a partir de los datos de la Encuesta Nacional de Calidad de Vida del año 2003. Para el análisis se emplea un modelo econométrico Probit Bivariado, que permite el estudio conjunto e interrelacionado de decisiones diferentes, en este caso la asistencia escolar y el trabajo.

  1. Adaptaciones de puestos de trabajo de centros de salud en trabajadores especialmente sensibles a riesgos laborales

    Directory of Open Access Journals (Sweden)

    Ana Padilla Fortes

    2014-09-01

    Full Text Available Este estudio explora los ajustes trabajo-persona realizados en trabajadores considerados especialmente sensibles a determinados riesgos laborales en el sector sanitario. El propósito de esta investigación fue ayudar a caracterizar las adaptaciones del puesto de trabajo con motivo de la comunicación de algún tipo de discapacidad o limitación de salud que interfiere en el desempeño de tareas. A lo largo del año 2012, en los centros de salud de un distrito de atención primaria se contabilizó un total de 46 trabajadores calificados especialmente sensibles que recibieron un promedio de 3,2 medidas de adaptación en el lugar y/o puesto de trabajo. Los hallazgos mostraron una amplia variedad de ajustes que incluyeron modificaciones en la organización del trabajo, en la forma de desempeñar las tareas, y en menor grado, cambios en los factores ambientales próximos al puesto y/o lugar de trabajo. Todas las medidas estuvieron encaminadas a facilitar la continuidad de la vida laboral dentro de unos límites compatibles con la seguridad y salud del trabajador. Nuestros resultados ofrecen una primera aproximación al conocimiento de los aspectos de gestión de las limitaciones de salud que menoscaban la capacidad de los trabajadores para responder a las demandas de trabajo.

  2. El trabajo colaborativo en red impulsor del desarrollo profesional del profesorado

    Directory of Open Access Journals (Sweden)

    MARIA JOSÉ NAVARRO MONTAÑO

    2017-01-01

    Full Text Available En este artículo se presenta un estudio de caso sobre una estrategia de aprendizaje colaborativo entre profesionales de la educación en un ámbito específico de trabajo, el alumnado con autismo, para apoyar el intercambio de experiencias a través de las redes. La muestra se compone de un equipo de 11 profesoras de aulas de autismo específicas, cuyo trabajo se basa en diseñar y contrastar estrategias educativas de actuación para este alumnado. La recogida de datos se ha realizado a través de entrevistas en grupo, cuestionarios y análisis del Plan de Trabajo. Los resultados indican que el trabajo planificado y consensuado, con una trayectoria común de participación continuada en el tiempo, ofrece una garantía de calidad que camina hacia la mejora en educación. Así, el grupo de trabajo ofrece seguridad profesional a sus participantes, favorece la consecución de objetivos comunes y evita el aisla ‑ miento profesional de los profesores en aulas específicas, ya que la comunicación en la red es la base de su trabajo.

  3. INTIMIDAD, SEXUALIDAD, DEMENCIAS. ESTRATEGIAS AFECTIVAS Y APROPIACIÓN DEL TRABAJO DE CUIDADO EN CONTEXTOS DESESTABILIZANTES

    Directory of Open Access Journals (Sweden)

    Natacha Borgeaud-Garciandía

    2016-01-01

    Full Text Available El presente artículo se centra en el trabajo de cuidado domiciliario en contextos que suponen la confrontación de las cuidadoras con elementos perturbadores y potencialmente desestabilizantes: la intimidad, la sexualidad y la demencia senil de adultos mayores muy dependientes. Proviene de una investigación en sociología cualitativa en la cual se llevaron a cabo entrevistas biográficas de tipo “historias de vida”con cuidadoras. Apoyándonos en las nociones de “trabajo sucio”, “trabajo emocional”y “defensas”, se analiza cómo estas trabajadoras se protegen y resignifican su trabajo ante la amenaza de sufrimiento que conlleva tal confrontación, lo cual puede resultar aún más difícil cuando los familiares rechazan el declive de su mayor. A la vez, la convivenciaprolongada les permite a las cuidadoras desarrollar un trabajo de cuidado integral, que pueden apreciar y repatriar en su buen cuidado. A través de sus estrategias emocionales, las cuidadoras resignifican el trabajo sucio a la vez que buscan preservar su identidad de “buena cuidadora”, socialmente valorada.

  4. El trabajo de menores artistas, científicos, deportistas, etc.

    Directory of Open Access Journals (Sweden)

    Aníbal GUZMÁN ÁVALOS

    2016-03-01

    Full Text Available El presente ensayo guarda como primer objetivo describir la evolución que ha tenido el derecho mexicano en torno a la regulación del trabajo infantil. Así, se parte del análisis de las primeras normas de carácter federal que regularon dicho fenómeno social, para finalizar en el estudio de las reformas realizadas en los años 2012 y 2014 a la Ley Federal del Trabajo y al artículo 123 Constitucional,respectivamente; reformas con las que fue posible armonizar el derecho mexicano con los instrumentos internacionales que protegen los derechos humanos de niñas y niños, los cuales también han sido objeto de estudio en el presente trabajo. Sumado a ello,y como segundo objetivo del presente trabajo,se analiza la reforma realizada en el año 2002 al artículo 175 Bis de la Ley Federal del Trabajo, a fin de demostrar la inconstitucionalidad de dicho artículo y su incompatibilidad con los documentos internacionales que postulan el principio del interés superior del niño, debido a que dicho numeral excluye de las modalidades de trabajo infantil las actividades artísticas, científicas, deportivas, etc.,que realizan los menores de catorce años.

  5. RIESGO DE TRABAJO OCURRIDOS CON PERSONAL DE UN HOSPITAL EN EL ESTADO DE JALISCO 2009

    Directory of Open Access Journals (Sweden)

    Sergio A. Franco C.

    2012-01-01

    Full Text Available Se presenta un análisis sobre accidentes de trabajo y de trayecto, del año 2009 en un hospital de seguridad social en el estado de Jalisco con el objetivo de evaluar accidentabilidad, se revisaron los formatos existentes en lo referente accidentes de trabajo y de trayecto, dándose una accidentabilidad de 106 riesgos de trabajo de los cuales 66 fueron accidentes de trabajo y 49 accidentes de trayecto, en dicho periodo. En la categoría de enfermera general, los accidentados de trabajo como de trayecto, fue la de mayor accidentabilidad con un 25.50% . En lo referente al área de trabajo y vía publica se tuvo el 37.74% en la vía publica. En las actividades que se realizaban, el de conducir vehículo obtuvo el 15.09% . En el turno matutino se dio la mayor accidentabilidad con el 54.72%. El mes de octubre fue el de mayor accidentabilidad con el 15.09%. en la región anatómica el cuello como los tobillos se dio el 20.75% respectivamente. El tipo de accidente, el movimiento brusco obtuvo el 48.11%. las causas de los accidentes por falta de atención se dio el 34.91% y el agente de la lesión fue reacción corporal con el 46.23%.

  6. Trabajo y Moralidad en las relaciones de producción capitalistas

    Directory of Open Access Journals (Sweden)

    GONZALO ASSUSA

    2014-08-01

    Full Text Available El Trabajo como praxis ha sido ubicado, en el contexto de la modernidad, en la esfera de "lo económico", pero los discursos que lo construyen como problema tienden a revestirlo con una serie de elementos normativos y valoraciones que no se condicen con las condiciones estructurales y las "reglas de juego" propias del mercado de trabajo del sistema capitalista. Reconstruiremos aquí algunos núcleos teóricos de abordaje de la relación entre Trabajo y Cultura en términos de Moral en el marco de una regulación capitalista de las relaciones de producción. Para esto recuperaremos fragmentos de la teoría de la solidaridad social de Emile Durkheim y su relectura en la obra de Jürgen Habermas. A partir de estas discusiones, plantearemos posibles líneas de análisis en torno a las necesidades sistémicas de articulación de esferas diferenciadas como las del Trabajo y la Moral, en un mundo del trabajo instrumentalizado y fragmentado. Por último, discutiremos la necesidad de conceptualizar la relación Trabajo - Moralidad, al mismo tiempo en términos de solidaridad y disputa.

  7. Características de los trabajos publicados sobre las propiedades de las plantas en revistas médicas peruanas

    Directory of Open Access Journals (Sweden)

    Oscar G. Pamo-Reyna

    2009-07-01

    Full Text Available Objetivo. Determinar las características de los trabajos originales sobre las propiedades de las plantas publicadas en revistas médicas peruanas. Material y métodos. Se revisó las bases de datos bibliográficas SciELO Perú y SISBIB para el período 2004-2008. Resultados. En 14 revistas se halló 825 trabajos originales, de los cuales 45 fueron incluidos en el estudio. El número de trabajos por años fue 3 (2004, 5 (2005, 9 2006, 13 (2007 y 15 (2008. Las revistas que publicaron mayor proporción de artículos sobre plantas fueron revistas de facultades de medicina: Rev Med Vallejiana (33%, Horizonte Médico (29% y An Fac Med (13%. Las instituciones que más publicaron fueron la Universidad Nacional Mayor de San Marcos (45,5%, Universidad San Martín de Porres (22% y Universidad Nacional de Trujillo (13%. De un total de 226 autores, 11 de ellos realizaron el 22,1% de la producción total. De 57 plantas estudiadas, las más investigadas fueron Lepidium sp. (maca, Croton palanostigma (sangre de grado, Calophyllum brasiliense (lagarto caspi y Smallanthus sonchifolius (yacón. Los potenciales usos más estudiados fueron nutritivos, antineoplásicos, antioxidante, hipoglicemiante e hipotensor arterial. Seis (13,3% trabajos fueron clínicos y el resto fue de tipo experimental o bioquímico. Conclusión. La producción científica médica relacionada con las propiedades de las plantas y publicada es escasa aunque creciente, se realiza en las universidades públicas y privadas, la participación privada es casi nula; y, existe una élite de investigadores que gran producción de trabajos.

  8. Vaccines for preventing infection with Pseudomonas aeruginosa in cystic fibrosis

    DEFF Research Database (Denmark)

    Johansen, H.K.; Gøtzsche, Peter C.; Johansen, Helle Krogh

    2008-01-01

    BACKGROUND: Chronic pulmonary infection in cystic fibrosis results in progressive lung damage. Once colonisation of the lungs with Pseudomonas aeruginosa occurs, it is almost impossible to eradicate. Vaccines, aimed at reducing infection with Pseudomonas aeruginosa, have been developed. OBJECTIVES......: To assess the effectiveness of vaccination against Pseudomonas aeruginosa in cystic fibrosis. SEARCH STRATEGY: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register using the terms vaccines AND pseudomonas (last search May 2008) and PubMed using the terms vaccin* AND cystic...... fibrosis (last search May 2008). SELECTION CRITERIA: Randomised trials (published or unpublished) comparing Pseudomonas aeruginosa vaccines (oral, parenteral or intranasal) with control vaccines or no intervention in cystic fibrosis. DATA COLLECTION AND ANALYSIS: The authors independently selected trials...

  9. Cystic fibrosis with normal sweat chloride concentration: case report

    Directory of Open Access Journals (Sweden)

    Silva Filho Luiz Vicente Ferreira da

    2003-01-01

    Full Text Available Cystic fibrosis is a genetic disease usually diagnosed by abnormal sweat testing. We report a case of an 18-year-old female with bronchiectasis, chronic P. aeruginosa infection, and normal sweat chloride concentrations who experienced rapid decrease of lung function and clinical deterioration despite treatment. Given the high suspicion ofcystic fibrosis, broad genotyping testing was performed, showing a compound heterozygous with deltaF508 and 3849+10kb C->T mutations, therefore confirming cystic fibrosis diagnosis. Although the sweat chloride test remains the gold standard for the diagnosis of cystic fibrosis, alternative diagnostic tests such as genotyping and electrophysiologic measurements must be performed if there is suspicion of cystic fibrosis, despite normal or borderline sweat chloride levels.

  10. Reversal of liver fibrosis: From fiction to reality.

    Science.gov (United States)

    Zoubek, Miguel Eugenio; Trautwein, Christian; Strnad, Pavel

    2017-04-01

    In chronic liver diseases, an ongoing hepatocellular injury together with inflammatory reaction results in activation of hepatic stellate cells (HSCs) and increased deposition of extracellular matrix (ECM) termed as liver fibrosis. It can progress to cirrhosis that is characterized by parenchymal and vascular architectural changes together with the presence of regenerative nodules. Even at late stage, liver fibrosis is reversible and the underlying mechanisms include a switch in the inflammatory environment, elimination or regression of activated HSCs and degradation of ECM. While animal models have been indispensable for our understanding of liver fibrosis, they possess several important limitations and need to be further refined. A better insight into the liver fibrogenesis resulted in a large number of clinical trials aiming at reversing liver fibrosis, particularly in patients with non-alcoholic steatohepatitis. Collectively, the current developments demonstrate that reversal of liver fibrosis is turning from fiction to reality. Copyright © 2017. Published by Elsevier Ltd.

  11. Blood lipids analysis in patients with hepatitis and hepatic fibrosis

    International Nuclear Information System (INIS)

    Si Jianhong

    2007-01-01

    Objective: To investigate the correlationship between blood hepatic fibrosis markers and blood lipids levels. Methods: Serum hepatic fibrosis markers (HA, PC III, IV-C, LN) levels were determined with RIA and serum lipids (TG, TCh HDL; LDL, apoA1, apoB) were measured with biochemical methods in 98 patients with hepatitis in various stages and 50 controls. Liver biopsy was done in all the hepatitis patients. Results: Hepatic fibrosis was classified into 5 grades (S0-S4) according to the pathology shown in the biopsy specimen. The serum lipid levels decreased along with the increase of severity of fibrosis from S0 to S4. Levels in S4 patients were significantly lower than those in controls (P 0.05). Conclusion: The serum hepatic fibrosis markers levels increased and lipids levels decreased along with the progress of hepatitis from acute to cirrhosis. (authors)

  12. Pathogenesis pathways of idiopathic pulmonary fibrosis in bleomycin-induced lung injury model in mice.

    Science.gov (United States)

    Shi, Keyun; Jiang, Jianzhong; Ma, Tieliang; Xie, Jing; Duan, Lirong; Chen, Ruhua; Song, Ping; Yu, Zhixin; Liu, Chao; Zhu, Qin; Zheng, Jinxu

    2014-01-01

    Our objective was to investigate the pathogenesis pathways of idiopathic pulmonary fibrosis (IPF). Bleomycin (BLM) induced animal models of experimental lung fibrosis were used. CHIP assay was executed to find the link between Smad3 and IL-31, and the expressions of TGF-β1, Smad3, IL-31 and STAT1 were detected to find whether they were similar with each other. We found that in the early injury or inflammation of the animal model, BLM promoted the development of inflammation, leading to severe pulmonary fibrosis. Then the expression of TGF-β1 and Smad3 increased. Activated Smad3 bound to the IL-31 promoter region, followed by the activation of JAK-STAT pathways. The inhibitor of TGF-β1 receptor decreased the IL-31 expression and knocking-down of IL-31 also decreased the STAT1 expression. We conclude that there is a pathway of pathogenesis in BLM-induced mouse model that involves the TGF-β, IL-31 and JAKs/STATs pathway. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B.

    Science.gov (United States)

    Hui, Chee-Kin; Zhang, Hai-Ying; Lee, Nikki P; Chan, Weng; Yueng, Yui-Hung; Leung, Kar-Wai; Lu, Lei; Leung, Nancy; Lo, Chung-Mau; Fan, Sheung-Tat; Luk, John M; Xu, Aimin; Lam, Karen S; Kwong, Yok-Lam; Lau, George K K

    2007-08-01

    Despite the possible role of adiponectin in the pathogenesis of liver cirrhosis, few data have been collected from patients in different stages of liver fibrosis. We studied the role of adiponectin in 2 chronic hepatitis B (CHB)-patient cohorts. Serum adiponectin was quantified by enzyme-linked immunosorbent assay. One-hundred liver biopsy specimens from CHB patients with different stages of fibrosis and 38 paired liver biopsies from hepatitis B e antigen-positive patients randomized to lamivudine (n=15), pegylated interferon alfa-2a (n=15) or pegylated interferon alfa-2a plus lamivudine (n=8) therapy for 48 weeks were assessed. Serum adiponectin was detected at levels ranging over fourfold magnitude with advancing fibrosis stage and correlated positively with fibrosis stage [r=0.45, p<0.001]. CHB patients with stage 0-1 fibrosis had higher composition of high molecular weight (HMW) form of adiponectin when compared with CHB patients with liver cirrhosis [mean+/-SEM 51.2+/-2.1% vs. 40.9+/-1.7%, respectively, p=0.001]. After antiviral therapy, patients with fibrosis reduction had marked decline in serum adiponectin level and increase in HMW form of adiponectin [mean+/-SEM 43.5+/-1.2% vs. 37.0+/-3.0%, respectively, p=0.04]. Serum adiponectin may have a role in fibrosis progression in CHB infection. A marked decline in serum adiponectin after antiviral therapy is associated with fibrosis reduction.

  14. Imaging the Abdominal Manifestations of Cystic Fibrosis

    Directory of Open Access Journals (Sweden)

    C. D. Gillespie

    2017-01-01

    Full Text Available Cystic fibrosis (CF is a multisystem disease with a range of abdominal manifestations including those involving the liver, pancreas, and kidneys. Recent advances in management of the respiratory complications of the disease has led to a greater life expectancy in patients with CF. Subsequently, there is increasing focus on the impact of abdominal disease on quality of life and survival. Liver cirrhosis is the most important extrapulmonary cause of death in CF, yet significant challenges remain in the diagnosis of CF related liver disease. The capacity to predict those patients at risk of developing cirrhosis remains a significant challenge. We review representative abdominal imaging findings in patients with CF selected from the records of two academic health centres, with a view to increasing familiarity with the abdominal manifestations of the disease. We review their presentation and expected imaging findings, with a focus on the challenges facing diagnosis of the hepatic manifestations of the disease. An increased familiarity with these abdominal manifestations will facilitate timely diagnosis and management, which is paramount to further improving outcomes for patients with cystic fibrosis.

  15. Imaging findings in congenital hepatic fibrosis

    International Nuclear Information System (INIS)

    Akhan, Okan; Karaosmanoglu, Ali Devrim; Ergen, Bilge

    2007-01-01

    Congenital hepatic fibrosis (CHF) is a rare congenital multisystemic disorder, mostly inherited in autosomal recessive fashion, primarily affecting renal and hepatobiliary systems. Main underlying process of the disease is the malformation of the ductal plate, the embryological precursor of the biliary system, and secondary biliary strictures and periportal fibrosis ultimately leading to portal hypertension. The natural course of the disease is highly variable ranging from minimally symptomatic disease to true cirrhosis of the liver. However, in most patients the most common manifestations of the diseases that are related to portal hypertension, particularly splenomegaly and bleeding varices. Many other disease processes may co-exist with the disease including Caroli's disease, choledochal cysts and autosomal recessive polycystic kidney disease (ARPKD) reflecting the mulstisystemic nature of the disease. The associating biliary ductal disease led the authors to think that all these entities are a continuum and different reflections of the same underlying pathophysiological process. Although, conventional method of diagnosis of CHF is the liver biopsy the advent of imaging technologies and modalities, today, may permit the correct diagnosis in a non-invasive manner. Characteristic imaging features are generally present and recognition of these findings may obviate liver biopsy while preserving the diagnostic accuracy. In this article, it is aimed to increase the awareness of the practising radiologists to the imaging findings of this uncommon clinical disorder and trail the blaze for future articles relating to this issue

  16. Global impact of bronchiectasis and cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Margarida Redondo

    2016-09-01

    To understand variation in the aetiology, microbiology and burden of bronchiectasis and cystic fibrosis across different global healthcare systems.; Bronchiectasis is the term used to refer to dilatation of the bronchi that is usually permanent and is associated with a clinical syndrome of cough, sputum production and recurrent respiratory infections. It can be caused by a range of inherited and acquired disorders, or may be idiopathic in nature. The most well recognised inherited disorder in Western countries is cystic fibrosis (CF, an autosomal recessive condition that leads to progressive bronchiectasis, bacterial infection and premature mortality. Both bronchiectasis due to CF and bronchiectasis due to other conditions are placing an increasing burden on healthcare systems internationally. Treatments for CF are becoming more effective leading to more adult patients with complex healthcare needs. Bronchiectasis not due to CF is becoming increasingly recognised, particularly in the elderly population. Recognition is important and can lead to identification of the underlying cause, appropriate treatment and improved quality of life. The disease is highly diverse in its presentation, requiring all respiratory physicians to have knowledge of the different “bronchiectasis syndromes”. The most common aetiologies and presenting syndromes vary depending on geography, with nontuberculous mycobacterial disease predominating in some parts of North America, post-infectious and idiopathic disease predominating in Western Europe, and post-tuberculosis bronchiectasis dominating in South Asia and Eastern Europe. Ongoing global collaborative studies will greatly advance our understanding of the international impact of bronchiectasis and CF.

  17. Is nintedanib effective for idiopathic pulmonary fibrosis?

    Directory of Open Access Journals (Sweden)

    Alejandro Jeldres

    2017-06-01

    Full Text Available Resumen La fibrosis pulmonar idiopática es una enfermedad de mal pronóstico y cuyas terapias efectivas son escasas. En la búsqueda de tratamientos que puedan modificar el curso de la enfermedad ha surgido como una alternativa el nintedanib (BIBF 1120, un inhibidor de tirosina kinasa. Sin embargo, su rol aún no está claro. Para responder esta pregunta utilizamos la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en múltiples fuentes de información. Identificamos siete revisiones sistemáticas que en conjunto incluyen siete estudios aleatorizados. Extrajimos los datos, realizamos un metanálisis y preparamos una tabla de resumen de los resultados utilizando el método GRADE. Concluimos que nintedanib probablemente disminuye el riesgo de exacerbaciones agudas, y podría reducir la mortalidad en la fibrosis pulmonar idiopática. Por otra parte, probablemente no se asocia a eventos adversos serios.

  18. Abdominal manifestations of cystic fibrosis in children

    International Nuclear Information System (INIS)

    Chaudry, Gulraiz; Navarro, Oscar M.; Levine, Daniel S.; Oudjhane, Kamaldine

    2006-01-01

    Pulmonary complications remain the main cause of mortality in cystic fibrosis, but the presenting symptoms in children are often related to gastrointestinal or pancreaticobiliary disease. Furthermore, abdominal manifestations are now seen throughout childhood, from infancy to adolescence. The child might present in the neonatal period with meconium ileus or its attendant complications. The older child might present with distal intestinal obstruction syndrome or colonic stricture secondary to high doses of pancreatic enzyme replacement. Less-common gastrointestinal manifestations include intussusception, duodenitis and fecal impaction of the appendix. Most children also show evidence of exocrine pancreatic deficiency. Radiologically, the combination of fat deposition and pancreatic fibrosis leads to varying CT and MR appearances. A higher than normal incidence of pancreatic cysts and calcification is also seen. Decreased transport of water and chloride also increases the viscosity of bile, with subsequent obstruction of the biliary ductules. If extensive, this can progress to obstructive cirrhosis, portal hypertension and esophageal varices. Diffuse fatty infiltration, hypersplenism and gallstones are also commonly seen in these patients. We present a pictorial review of the radiological appearance of these abdominal manifestations. The conditions are dealt with individually, together with typical appearances in various imaging modalities. (orig.)

  19. Cystic fibrosis chronic rhinosinusitis: A comprehensive review

    Science.gov (United States)

    Chaaban, Mohamad R.; Kejner, Alexandra; Rowe, Steven M.

    2013-01-01

    Background: Advances in the care of patients with cystic fibrosis (CF) have improved pulmonary outcomes and survival. In addition, rapid developments regarding the underlying genetic and molecular basis of the disease have led to numerous novel targets for treatment. However, clinical and basic scientific research focusing on therapeutic strategies for CF-associated chronic rhinosinusitis (CRS) lags behind the evidence-based approaches currently used for pulmonary disease. Methods: This review evaluates the available literature and provides an update concerning the pathophysiology, current treatment approaches, and future pharmaceutical tactics in the management of CRS in patients with CF. Results: Optimal medical and surgical strategies for CF CRS are lacking because of a dearth of well-performed clinical trials. Medical and surgical interventions are supported primarily by level 2 or 3 evidence and are aimed at improving clearance of mucus, infection, and inflammation. A number of novel therapeutics that target the basic defect in the cystic fibrosis transmembrane conductance regulator channel are currently under investigation. Ivacaftor, a corrector of the G551D mutation, was recently approved by the Food and Drug Administration. However, sinonasal outcomes using this and other novel drugs are pending. Conclusion: CRS is a lifelong disease in CF patients that can lead to substantial morbidity and decreased quality of life. A multidisciplinary approach will be necessary to develop consistent and evidence-based treatment paradigms. PMID:24119602

  20. Natural Killer cells and liver fibrosis

    Directory of Open Access Journals (Sweden)

    Frank eFasbender

    2016-01-01

    Full Text Available In the 40 years since the discovery of Natural Killer (NK cells it has been well established that these innate lymphocytes are important for early and effective immune responses against transformed cells and infections with different pathogens. In addition to these classical functions of NK cells, we now know that they are part of a larger family of innate lymphoid cells and that they can even mediate memory-like responses. Additionally, tissue resident NK cells with distinct phenotypical and functional characteristics have been identified. Here we focus on the phenotype of different NK cell subpopulations that can be found in the liver and summarize the current knowledge about the functional role of these cells with a special emphasis on liver fibrosis. NK cell cytotoxicity can contribute to liver damage in different forms of liver disease. However, NK cells can limit liver fibrosis by killing hepatic stellate cell-derived myofibroblasts, which play a key role in this pathogenic process. Therefore, liver NK cells need to be tightly regulated in order to balance these beneficial and pathological effects.

  1. Urinary incontinence in patients with cystic fibrosis.

    Science.gov (United States)

    Reichman, Gina; De Boe, Veerle; Braeckman, Johan; Michielsen, Dirk

    2016-01-01

    Owing to evolution in treatment, the average life expectancy of patients with cystic fibrosis (CF) has increased. This has been followed by an increase in urological complications such as urinary incontinence. As stress incontinence occurs during exercise, it may have a negative effect on the implementation of respiratory physiotherapy. The purpose of this study is to determine the prevalence of urinary incontinence and its effect on the quality of life and physiotherapy in a population with CF. Questionnaires were used to determine the prevalence of incontinence in patients of the Cystic Fibrosis Clinic of the University Hospital in Brussels. Two different surveys were used, depending on the age of the patients (incontinence were emphasized. Questionnaires were completed by 122 participants aged 6-59 years, showing an overall prevalence of 27% for urinary incontinence. Mainly adults reported urinary incontinence, with a prevalence of 11% in men and 68% in women aged 12 and above. The amount of urinary leakage was usually only a few drops and it was mainly triggered by coughing. Many of the participants had never mentioned this symptom to anyone. Doctors' and physical therapists' attention should be drawn to the fact that urinary incontinence is part of the complication spectrum of CF. A quarter of the study population refrained from coughing up phlegm and from physiotherapy. It is important to actively question and inform about this problem, to enable its detection and treatment.

  2. Psychosocial problems in children with cystic fibrosis

    DEFF Research Database (Denmark)

    Bregnballe, V; Thastum, M; Schiøtz, P O

    2007-01-01

    AIM: To compare the well-being of children (7-14 years) with cystic fibrosis (CF) (n = 43) with the well-being of healthy controls (n = 1121). METHODS: The self-report questionnaire Beck Youth Inventories (BYI) was used to study depression, anxiety, anger, disruptive behaviour and self-concept in......AIM: To compare the well-being of children (7-14 years) with cystic fibrosis (CF) (n = 43) with the well-being of healthy controls (n = 1121). METHODS: The self-report questionnaire Beck Youth Inventories (BYI) was used to study depression, anxiety, anger, disruptive behaviour and self......-concept in children with CF. A measure of social desirability was included as well as body mass index (BMI) and percentage of predicted forced expiratory volume in one second (FEV(1)) as measures of health status. RESULTS: The children with CF did not differ from the norm group concerning depression, disruptive...... behaviour and self-concept. Young children with CF (7-10 years) and boys with CF scored significantly higher on anxiety. Girls with CF scored significantly lower on anger than controls. BMI was not associated with any of the BYI subscales. In patients aged 11-14 years, there was a significant correlation...

  3. Is pirfenidone effective for idiopathic pulmonary fibrosis?

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    Alejandro Jeldres

    2017-03-01

    Full Text Available Resumen Se ha planteado que la pirfenidona, un agente antifibrótico, podría cambiar el curso de la fibrosis pulmonar idiopática, una enfermedad de pronóstico ominoso y para la cual prácticamente no existen terapias efectivas. Utilizando la base de datos Epistemonikos, la cual es mantenida mediante búsquedas en múltiples bases de datos, identificamos trece revisiones sistemáticas que en conjunto incluyen nueve estudios primarios, siete de los cuales son aleatorizados y cuyos resultados se analizaron en este resumen. Extrajimos los datos, realizamos un metanálisis y preparamos tablas de resumen de los resultados utilizando el método GRADE. Concluimos que la pirfenidona disminuye la progresión de la enfermedad y la mortalidad en la fibrosis pulmonar idiopática. Si bien se asocia a efectos adversos gastrointestinales y cutáneos frecuentes, estos en general no son severos.

  4. PROFILEing idiopathic pulmonary fibrosis: rethinking biomarker discovery

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    Toby M. Maher

    2013-06-01

    Full Text Available Despite major advances in the understanding of the pathogenesis of idiopathic pulmonary fibrosis (IPF, diagnosis and management of the condition continue to pose significant challenges. Clinical management of IPF remains unsatisfactory due to limited availability of effective drug therapies, a lack of accurate indicators of disease progression, and an absence of simple short-term measures of therapeutic response. The identification of more accurate predictors of prognosis and survival in IPF would facilitate counseling of patients and their families, aid communication among clinicians, and would guide optimal timing of referral for transplantation. Improvements in molecular techniques have led to the identification of new disease pathways and a more targeted approach to the development of novel anti-fibrotic agents. However, despite an increased interest in biomarkers of IPF disease progression there are a lack of measures that can be used in early phase clinical trials. Careful longitudinal phenotyping of individuals with IPF together with the application of novel omics-based technology should provide important insights into disease pathogenesis and should address some of the major issues holding back drug development in IPF. The PROFILE (Prospective Observation of Fibrosis in the Lung Clinical Endpoints study is a currently enrolling, prospective cohort study designed to tackle these issues.

  5. Fibroblasts in fibrosis: novel roles and mediators

    Directory of Open Access Journals (Sweden)

    Ryan Thomas Kendall

    2014-05-01

    Full Text Available Fibroblasts are the most common cell type of the connective tissues found throughout the body and the principal source of the extensive extracellular matrix (ECM characteristic of these tissues. They are also the central mediators of the pathological fibrotic accumulation of ECM and the cellular proliferation and differentiation that occurs in response to prolonged tissue injury and chronic inflammation. The transformation of the fibroblast cell lineage involves classical developmental signaling programs and includes a surprisingly diverse range of precursor cell types—most notably, myofibroblasts that are the apex of the fibrotic phenotype. Myofibroblasts display exaggerated ECM production; constitutively secrete and are hypersensitive to chemical signals such as cytokines, chemokines, and growth factors; and are endowed with a contractile apparatus allowing them to manipulate the ECM fibers physically to close open wounds. In addition to ECM production, fibroblasts have multiple concomitant biological roles, such as in wound healing, inflammation, and angiogenesis, which are each interwoven with the process of fibrosis. We now recognize many common fibroblast-related features across various physiological and pathological protracted processes. Indeed, a new appreciation has emerged for the role of noncancerous fibroblast interactions with tumors in cancer progression. Although the predominant current clinical treatments of fibrosis involve nonspecific immunosuppressive and anti-proliferative drugs, a variety of potential therapies under investigation specifically target fibroblast biology.

  6. Abdominal manifestations of cystic fibrosis in children

    Energy Technology Data Exchange (ETDEWEB)

    Chaudry, Gulraiz; Navarro, Oscar M.; Levine, Daniel S.; Oudjhane, Kamaldine [University of Toronto, Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON (Canada)

    2006-03-15

    Pulmonary complications remain the main cause of mortality in cystic fibrosis, but the presenting symptoms in children are often related to gastrointestinal or pancreaticobiliary disease. Furthermore, abdominal manifestations are now seen throughout childhood, from infancy to adolescence. The child might present in the neonatal period with meconium ileus or its attendant complications. The older child might present with distal intestinal obstruction syndrome or colonic stricture secondary to high doses of pancreatic enzyme replacement. Less-common gastrointestinal manifestations include intussusception, duodenitis and fecal impaction of the appendix. Most children also show evidence of exocrine pancreatic deficiency. Radiologically, the combination of fat deposition and pancreatic fibrosis leads to varying CT and MR appearances. A higher than normal incidence of pancreatic cysts and calcification is also seen. Decreased transport of water and chloride also increases the viscosity of bile, with subsequent obstruction of the biliary ductules. If extensive, this can progress to obstructive cirrhosis, portal hypertension and esophageal varices. Diffuse fatty infiltration, hypersplenism and gallstones are also commonly seen in these patients. We present a pictorial review of the radiological appearance of these abdominal manifestations. The conditions are dealt with individually, together with typical appearances in various imaging modalities. (orig.)

  7. Imaging findings in congenital hepatic fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Akhan, Okan [Department of Radiology, Hacettepe University, School of Medicine, 06100 Ankara (Turkey)]. E-mail: akhano@tr.net; Karaosmanoglu, Ali Devrim [Department of Radiology, Hacettepe University, School of Medicine, 06100 Ankara (Turkey); Ergen, Bilge [Department of Radiology, Hacettepe University, School of Medicine, 06100 Ankara (Turkey)

    2007-01-15

    Congenital hepatic fibrosis (CHF) is a rare congenital multisystemic disorder, mostly inherited in autosomal recessive fashion, primarily affecting renal and hepatobiliary systems. Main underlying process of the disease is the malformation of the ductal plate, the embryological precursor of the biliary system, and secondary biliary strictures and periportal fibrosis ultimately leading to portal hypertension. The natural course of the disease is highly variable ranging from minimally symptomatic disease to true cirrhosis of the liver. However, in most patients the most common manifestations of the diseases that are related to portal hypertension, particularly splenomegaly and bleeding varices. Many other disease processes may co-exist with the disease including Caroli's disease, choledochal cysts and autosomal recessive polycystic kidney disease (ARPKD) reflecting the mulstisystemic nature of the disease. The associating biliary ductal disease led the authors to think that all these entities are a continuum and different reflections of the same underlying pathophysiological process. Although, conventional method of diagnosis of CHF is the liver biopsy the advent of imaging technologies and modalities, today, may permit the correct diagnosis in a non-invasive manner. Characteristic imaging features are generally present and recognition of these findings may obviate liver biopsy while preserving the diagnostic accuracy. In this article, it is aimed to increase the awareness of the practising radiologists to the imaging findings of this uncommon clinical disorder and trail the blaze for future articles relating to this issue.

  8. Reversible myocardial ischaemia or irreversible myocardial fibrosis

    International Nuclear Information System (INIS)

    Mathey, D.; Hanrath, P.; Kupper, W.; Bleifeld, W.; Montz, R.; Knop, J.; Stritzke, P.; Kroeger, E.; Bleese, N.

    1978-01-01

    The results of biphasis 201 thallium ( 201 Tl) scanning were compared with those of coronary arteriography, left ventricular angiography and stress ECG in 56 patients with coronary artery disease and six with no evidence of heart disease. There were 104 201 Tl defects, 50 of them reversible. The defects were always located in the area supplied by a critically stenotic coronary artery. Correlation of regional wall motion with 201 Tl activity demonstrated that in all forms of abnormal wall motion there was either ischaemia or fibrosis. The resting LV angiogram thus does not make it possible to distinguish between myocardial ischaemia and fibrosis. Taking the LV angiogram as a standard, the rate of false-positive 201 Tl scintigrams was 5%, that of false-negative ones 23%. The biphasic 201 Tl scintigram was more sensitive than the stress ECG in detecting myocardial ischaemia. It furthermore made it possible to localize the ischaemic (or fibrotic) region within the LV and to estimate its size. (orig.) [de

  9. Leptospira Interrogans Induces Fibrosis in the Mouse Kidney through Inos-Dependent, TLR- and NLR-Independent Signaling Pathways

    Science.gov (United States)

    Fanton d'Andon, Martine; Quellard, Nathalie; Fernandez, Béatrice; Ratet, Gwenn; Lacroix-Lamandé, Sonia; Vandewalle, Alain; Boneca, Ivo G.; Goujon, Jean-Michel; Werts, Catherine

    2014-01-01

    Background Leptospira (L.) interrogans are bacteria responsible for a worldwide reemerging zoonosis. Rodents carry L. interrogans asymptomatically in their kidneys and excrete bacteria in the urine, contaminating the environment. Humans get infected through skin contact and develop a mild or severe leptospirosis that may lead to renal failure and fibrosis. L. interrogans provoke an interstitial nephritis, but the induction of fibrosis caused by L. interrogans has not been studied in murine models. Innate immune receptors from the TLR and NLR families have recently been shown to play a role in the development and progression of tissue fibrosis in the lung, liver and kidneys under different pathophysiological situations. We recently showed that TLR2, TLR4, and NLRP3 receptors were crucial in the defense against leptospirosis. Moreover, infection of a human cell line with L. interrogans was shown to induce TLR2-dependent production of fibronectin, a component of the extracellular matrix. Therefore, we thought to assess the presence of renal fibrosis in L. interrogans infected mice and to analyze the contribution of some innate immune pathways in this process. Methodology/principal findings Here, we characterized by immunohistochemical studies and quantitative real-time PCR, a model of Leptospira-infected C57BL/6J mice, with chronic carriage of L. interrogans inducing mild renal fibrosis. Using various strains of transgenic mice, we determined that the renal infiltrates of T cells and, unexpectedly, TLR and NLR receptors, are not required to generate Leptospira-induced renal fibrosis. We also show that the iNOS enzyme, known to play a role in Leptospira-induced interstitial nephritis, also plays a role in the induction of renal fibrosis. Conclusion/significance To our knowledge, this work provides the first experimental murine model of sustained renal fibrosis induced by a chronic bacterial infection that may be peculiar, since it does not rely on TLR or NLR receptors

  10. Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis.

    Science.gov (United States)

    Chung, Ki Wung; Jeong, Hyeong Oh; Lee, Bonggi; Park, Daeui; Kim, Dae Hyun; Choi, Yeun Ja; Lee, Eun Kyeong; Kim, Kyung Mok; Park, June Whoun; Yu, Byung Pal; Chung, Hae Young

    2017-01-31

    Chronic inflammation is a major contributor to age-related nephropathic changes, including renal fibrosis. In this study, various experimental paradigms were designed to delineate the role played by NF-κBIZ (also known as IκBζ) in age-associated renal fibrosis. Analyses based on RNA-sequencing findings obtained by next generation sequencing (NGS) revealed the upregulations of NF-κBIZ and of IL-6 and MCP-1 (both known to be regulated by NF-κBIZ) during aging. The up-regulation of NF-κBIZ in aged rat kidneys coincided with increased macrophage infiltration. In LPS-treated macrophages, oxidative stress was found to play a pivotal role in NF-κBIZ expression, suggesting age-related oxidative stress is associated with NF-κBIZ activation. Furthermore, these in vitro findings were confirmed in LPS-treated old rats, which showed higher levels of oxidative stress and NF-κBIZ in kidneys than LPS-treated young rats. Additional in vitro experiments using macrophages and kidney fibroblasts demonstrated NF-κBIZ and related cytokines participate in fibrosis. In particular, increased levels of NF-κBIZ-associated cytokines in macrophages significantly up-regulated TGF-β induced kidney fibroblast activation. Moreover, experiments with NF-κBIZ knocked down macrophages showed reduced TGF-β-induced kidney fibroblast activation. The findings of the present study provide evidence regarding an involvement of NF-κBIZ in age-associated progressive renal fibrosis and provides potential targets for its prevention.

  11. Relaciones trabajo-familia y salud en mujeres trabajadoras Work-family relationships and health in working women

    Directory of Open Access Journals (Sweden)

    Lya Feldman

    2008-12-01

    Full Text Available OBJETIVO: Estudiar la asociación existente entre las gratificaciones y las interferencias generadas en la relación trabajo-familia y su impacto en la salud de mujeres trabajadoras. MATERIAL Y MÉTODOS: Se utilizó un diseño no experimental correlacional. Se aplicó en Caracas, Venezuela, durante el año 2006, a un grupo de 402 mujeres trabajadoras con edades comprendidas entre 27 y 71 años, una batería de pruebas para medir relación trabajo-familia, autoestima, ansiedad, depresión, bienestar, percepción de salud y número de síntomas. RESULTADOS: Se encontró que las gratificaciones en la relación trabajo-familia están relacionadas con un mayor bienestar y autoestima, así como con menor depresión, ansiedad y síntomas reportados. Una mayor interferencia se asoció a una mayor depresión, ansiedad y número de síntomas. CONCLUSIONES: Los resultados permiten identificar algunos factores protectores y de riesgo para la salud de las mujeres con roles múltiples y sirven de base para el diseño de planes de intervención tanto en el plano individual como organizacional.OBJECTIVE: To study the relationship between gratifications and interferences generated in the work-family relationship and its impact on working women's health. MATERIAL AND METHODS: A non-experimental, correlational design was used. A group of 402 working women between 27 and 71 years of age were tested in Caracas, Venezuela during 2006, to measure work-family relationship, self-esteem, anxiety, depression, wellbeing, health perception and number of symptoms. RESULTS: It was found that the gratifications in the work-family relationship are related to better wellbeing and self-esteem, less depression, anxiety and symptom report. Presence of more interferences was associated with more depression, anxiety and number of symptoms. CONCLUSIONS: These results give an indication of protective and risk factors for multiple-role women's health and could provide some guidelines

  12. Accidentes de trabajo fatales y violencia interpersonal en Brasil, 2000-2010

    Directory of Open Access Journals (Sweden)

    Vilma Sousa Santana

    2013-01-01

    Full Text Available En el presente estudio se estima la mortalidad proporcional por accidentes de trabajo provocados por violencia interpersonal en Brasil, entre 2000 y 2010. Se analizaron los datos del Sistema de Información sobre Mortalidad, basados en los informes estadísti- cos de defunción del Ministerio de Salud de Brasil, los cuales incluyen un campo para el registro de accidentes de trabajo que debe ser completado en toda defunción por causas externas. Se identificaron 1.368.732 casos de defunciones por causas externas, 31.576 (2,3% por accidentes de trabajo y solo 226 (0,02% por accidentes de trabajo con violen- cia interpersonal. Cerca del 80% de los informes estadísticos de defunción no tenían el campo “accidente de trabajo” completado. La mayor cantidad de casos ocurrió entre hom- bres (94,3% de 25-34 años, con nivel de escolaridad medio, ubicados en la región sudeste y noreste, que trabajan principalmente en la producción de bienes y servicios industriales y la actividad agropecuaria. La mayoría de los casos fueron causados por armas de fuego, seguidos por armas blancas, con un aumento relativo de estos últimos en el período estu- diado. Los resultados sugieren un gran subregistro de diagnósticos que reconocen la rela- ción con el trabajo. Se hace necesaria una mejor capacitación en el llenado de los informes estadísticos, así como estudios que cuantifiquen el subregistro de accidentes de trabajo y accidentes de trabajo con violencia interpersonal.

  13. Tumoral fibrosis effect on the radiation absorbed dose of 177Lu-Tyr3-octreotate-gold nanoparticles and 177Lu-Tyr3-octreotate radiopharmaceuticals

    International Nuclear Information System (INIS)

    Zambrano R, O. D.

    2015-01-01

    In this work was comparatively evaluated the effect of tumoral fibrosis in the radiation absorbed dose of the radiopharmaceutical 177 Lu-Tyr 3 -octreotate with and without gold nanoparticles. For this, was used an experimental array of tumoral fibrosis and computer models based on Monte Carlo calculations to simulate tumoral micro environments without fibrosis and with fibrosis. The computer simulation code Penelope (Penetration Energy Loss of Positron and Electrons) and MCNP (Monte Carlo N-particle Transport Code System) which are based on the Monte Carlo methodology were used to create the computer models for the simulation of the transport of particles (emitted by 177 Lu) in the micro environments (without fibrosis and with fibrosis) with the purpose of calculating the radiation absorbed dose in the interstitial space and in the nucleus of cancer cells. The first computational model consisted of multiple concentric spheres (as onion shells) with the radioactive source homogeneously distributed in the shell between 5 and 10 μm in diameter which represents the internalization of the radioactive source into the cell cytoplasm as it occurs in target specific radiotherapy. The concentric spheres were useful to calculate the radiation absorbed dose in depth in the models without fibrosis and with fibrosis. Furthermore, there were constructed other computer models using two different codes that simulate the transport of radiation (Penelope and MCNP). These models consist of seven spheres that represent cancer cells (HeLa cells) of 10 μm in diameter and each one of them contain another smaller sphere in the center that represents the cell nucleus. A comparison was done of the radiation absorbed dose in the nucleus of the cells, calculated with both codes, Penelope and MCNP. The radioactive source ( 177 Lu) used for the simulations was given to the codes by means of a convoluted spectrum of the most important beta particles (high percentage emission). To this spectrum

  14. Pancreatic fibrosis correlates with exocrine pancreatic insufficiency after pancreatoduodenectomy.

    Science.gov (United States)

    Tran, T C K; van 't Hof, G; Kazemier, G; Hop, W C; Pek, C; van Toorenenbergen, A W; van Dekken, H; van Eijck, C H J

    2008-01-01

    Obstruction of the pancreatic duct can lead to pancreatic fibrosis. We investigated the correlation between the extent of pancreatic fibrosis and the postoperative exocrine and endocrine pancreatic function. Fifty-five patients who were treated for pancreatic and periampullary carcinoma and 19 patients with chronic pancreatitis were evaluated. Exocrine pancreatic function was evaluated by fecal elastase-1 test, while endocrine pancreatic function was assessed by plasma glucose level. The extent of fibrosis, duct dilation and endocrine tissue loss was examined histopathologically. A strong correlation was found between pancreatic fibrosis and elastase-1 level less than 100 microg/g (p pancreatic insufficiency. A strong correlation was found between pancreatic fibrosis and endocrine tissue loss (p pancreatic fibrosis nor endocrine tissue loss were correlated with the development of postoperative diabetes mellitus. Duct dilation alone was neither correlated with exocrine nor with endocrine function loss. The majority of patients develop severe exocrine pancreatic insufficiency after pancreatoduodenectomy. The extent of exocrine pancreatic insufficiency is strongly correlated with preoperative fibrosis. The loss of endocrine tissue does not correlate with postoperative diabetes mellitus. Preoperative dilation of the pancreatic duct per se does not predict exocrine or endocrine pancreatic insufficiency postoperatively. Copyright 2008 S. Karger AG, Basel.

  15. Pierre Naville y la otra sociología del trabajo Pierre Naville y la otra sociología del trabajo

    Directory of Open Access Journals (Sweden)

    Jorge García López

    2001-01-01

    Full Text Available This paper tries to draw a new perspective on Pierre Naville’s work, essential for the consolidation of the Sociology of Labour in France but nevertheless almost unknown and frequently misunderstood in Spain. Our interpretation is based on the debates held by Naville with his collaborators about the theoretical and methodological positions adopted by this branch of studies at the very first moment of its institutionalization in the sixties. These debates can be summarized in three main lines: (1 the criticism to the reduction of the object «work» into «post, process and situation». (2 The questioning of the analytical frame which studied the evolution of «work» taking for granted the natural unity among the producer, his tool, his activity and his product, unity represented by the craftsman. (3 The criticism to the methodological procedures that eluded both the problem of time — taking only into account the single instant— and measure —ignoring the study of salary—. These three splits contribute to shift the problem of waged labour from the technical and organizational conformation of posts and processes of work and the social and institutional forms of employments and socially built job markets, to the relationships between works and work force, posts and jobs, technical and social divisions of work, considering that this relationships structure the subject’s life (times of work/leisure/recovering. Finally, we argue that this shift can be useful to outline a theoretical link between the two shores existing in current European Sociology of Labour: a Sociology based in the work situation and a Sociology based in the labour marketEste artículo traza un particular itinerario sobre la obra de Pierre Naville, autor esencial en las primeras etapas de la consolidación de la sociología del trabajo en Francia pero que, a pesar de ello, resulta aún mayormente desconocido y no siempre bien interpretado en nuestro país. Este

  16. Entre cifras y normas legales: el trabajo de los menores en Bolivia Entre cifras y normas legales: el trabajo de los menores en Bolivia

    Directory of Open Access Journals (Sweden)

    María Yamile Hayes Michel

    2012-04-01

    Full Text Available El presente artículo aborda la temática del trabajo de niños, niñas y adolescentes en Bolivia, a partir de una revisión de la normativa legal vigente, que pretende protegerlos, las cifras y datos estadísticos sobre este tipo de trabajo, y la relación entre las disposiciones legales y la realidad del trabajo en la calle y fuera de ella, evidenciando que resta mucho camino por recorrer para que se produzca una auténtica tutela de los derechos de los menores trabajadores.This The present article have the issue of child and teenager labor in Bolivia, from a review of the current legislation, that pretends to protect them, the statistics number about this kind of works and the relation between the legal dispositions and the job reality in the street and also outside it, showing that much remains to be done to produce a real protection of the rights of working children.

  17. Condiciones objetivas y subjetivas de trabajo y trastornos psicofísicos

    Directory of Open Access Journals (Sweden)

    Margarita Pulido-Navarro

    Full Text Available Se analiza la relación entre las condiciones laborales, los trastornos psicofísicos y la valoración sobre el contenido del trabajo en una industria químico farmacéutica en México. Se llevó a cabo un estudio transversal a través de la aplicación de tres instrumentos: una guía de observación del proceso de trabajo, una guía para valorar las condiciones de seguridad e higiene en la empresa y una encuesta epidemiológica (N = 377. Los resultados muestran un proceso laboral muy automatizado, pero con una organización del trabajo principalmente fordista. Se encontraron fuertes asociaciones entre conjuntos de exigencias y conjuntos patológicos. La percepción que la población en estudio tiene de su trabajo (valoración, satisfacción, contenido, apoyo social muestra relación con algunos daños a la salud. Se pudo concluir que tanto las condiciones objetivas de trabajo como las subjetivas juegan un papel importante en la generación de enfermedades en los trabajadores.

  18. Espacialidad y trabajo: los cartoneros en la ciudad de La Plata

    Directory of Open Access Journals (Sweden)

    María Eugenia Rausky

    2016-04-01

    Full Text Available En el trabajo que aquí presentamos se aborda la forma que asume el vínculo espacio-trabajo para quienes viven de la recolección de basura, cartón, papel y afines, es decir, los cartoneros –niños y adultos-. Nos preguntamos por el modo en que una actividad que se desarrolla en el espacio público, es vivida por los sujetos que la practican: ¿Qué particularidades asume el trabajo que se lleva a cabo en las calles? ¿Cómo es vivida, sentida y practicada la ciudad por los trabajadores que despliegan sus actividades laborales en la vía pública? ¿Qué tipo de sociabilidad se desarrolla en el espacio de trabajo? ¿Qué vínculos tejen con el centro de la ciudad aquellos habitantes que viven en los márgenes? Nos interesa caracterizar los modos que tienen de practicar y representar el espacio laboral, analizando las repercusiones de ello en los sentidos que los sujetos le asignan a su trabajo. La estrategia de investigación empleada es cualitativa y está basada en entrevistas en profundidad y observación participante.

  19. Diversificación y fragmentación del mundo del trabajo en la hipermodernidad

    Directory of Open Access Journals (Sweden)

    Clara Betty Weisz Kohn

    2016-11-01

    Full Text Available El mundo del trabajo en la hipermodernidad se caracteriza por la fragmentación y diversidad de modalidades de inserción laboral, donde coexisten condiciones de trabajo típicas del industrialismo asalariado, junto a la informalidad, las políticas sociales de empleo, los modos de contratación flexible, y los emprendimientos autogestionados, entre otros. Dicha polarización y discontinuidad produce múltiples imaginarios sociales, representaciones sociales del trabajo en construcción e identidades laborales en movimiento. La epistemología y la metodología de la psicosociología y la sociología clínica constituyeron la perspectiva desde la cual se llevaron a cabo investigaciones en la temática, articuladas con la enseñanza y las actividades de extensión universitaria. Hiperpresencialidad del mundo del trabajo, incertidumbre, trayectorias laborales yuxtapuestas; construcción de subjetividad a partir de vínculos y pertenencias fragilizadas; placer y sufrimiento en el trabajo; así como gran dificultad para que se desarrollen sujetos colectivos; son los principales resultados obtenidos en el proceso de co-construcción de conocimiento con los propios trabajadores.

  20. Comparación de las diferentes escalas de valores de trabajo

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    BEATRIZ C. MARTÍNEZ SÁNCHEZ

    2000-01-01

    Full Text Available Los valores de trabajo son variables que se deben tener en cuenta a la hora de tomar decisiones concernientes a las opciones vocacionales, ya que la jerarquía de valores de trabajo que posea un individuo va a afectar a la hora de elegir un tipo de estudios u otro o a la hora de escoger una profesión. Con el fin de averiguar la jerarquía de valores de los individuos muchos autores elaboraron diferentes inventarios, clasificaciones y escalas, pero la mayoría de los valores que contienen son comunes a todas ellas, aunque puedan aparecer con otro nombre. Para comprobarlo en este artículo hemos realizado una comparación de las escalas de valores de trabajo más nombradas, tomando como referencia la escala de valores de trabajo de Super (1970. Esta revisión nos ha permitido elaborar una escala de valores de trabajo propia, que forma parte de los Sistemas de Asesoramiento y Autoayuda Vocacional (Rivas, Rocabert, López,1998.

  1. Condiciones objetivas y subjetivas de trabajo y trastornos psicofísicos

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    Pulido-Navarro Margarita

    2003-01-01

    Full Text Available Se analiza la relación entre las condiciones laborales, los trastornos psicofísicos y la valoración sobre el contenido del trabajo en una industria químico farmacéutica en México. Se llevó a cabo un estudio transversal a través de la aplicación de tres instrumentos: una guía de observación del proceso de trabajo, una guía para valorar las condiciones de seguridad e higiene en la empresa y una encuesta epidemiológica (N = 377. Los resultados muestran un proceso laboral muy automatizado, pero con una organización del trabajo principalmente fordista. Se encontraron fuertes asociaciones entre conjuntos de exigencias y conjuntos patológicos. La percepción que la población en estudio tiene de su trabajo (valoración, satisfacción, contenido, apoyo social muestra relación con algunos daños a la salud. Se pudo concluir que tanto las condiciones objetivas de trabajo como las subjetivas juegan un papel importante en la generación de enfermedades en los trabajadores.

  2. Riesgos ergonómicos que afecta al trabajo empresarial en el hospital civil de Chone

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    César Augusto Velásquez Giler

    2017-07-01

    Full Text Available El presente estudio tiene como objetivo identificar los riesgos ergonómicos que afectan al trabajo empresarial, caso particular Hospital Civil de Chone, para determinar los factores ergonómicos y los índices de bienestar general como factores de riesgo laboral. Se incluyeron para el análisis a 40 profesionales de la salud que realizan atención directa al paciente internado. En cuanto a las técnicas, se hizo uso de la investigación de campo, descriptiva, documental y transversal, para la obtención de información específica del tema propuesto, de igual manera se utilizó el método inductivo-deductivo, mientras que el instrumento para la recolección de datos se manejó una matriz de evaluación de riesgos para registrar los factores ergonómicos, se tomó las siguientes áreas ocupacionales como muestra: enfermeros, auxiliares de enfermería, secretarias, identificando los principales factores de riesgos ergonómicos que se expone el capital humano del hospital en condiciones de trabajo no recomendables, disminuyendo la productividad del trabajo   Palabras clave: salud, bienestar, condiciones de trabajo, capital humano, productividad del trabajo.

  3. Trabajo emocional y burnout: un estudio con policías militares

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    Joatã Soares Coelho Alves

    2017-09-01

    Full Text Available El objetivo de esta investigación fue verificar el papel predictor del trabajo emocional en la incidencia del burnout en policías militares. Participaron 525 militares profesionales: 408 hombres y 117 mujeres. Tres escalas adaptadas para portugués fueron usadas en el estudio: Emotional Labour Scale, Emotion Work Requirements Scale y la subescala de agotamiento emocional de Maslach Burnout Inventory. Análisis de regresión múltiple fueron realizados para evaluar el poder predictivo de las dimensiones de trabajo emocional y de variables sociodemográficas sobre el burnout. Los resultados indican que todas las dimensiones de trabajo emocional se mostraron como predictores de burnout: variedad e intensidad de las emociones, frecuencia de interacción con sospechosos y criminales, regulación profunda y regulación superficial, y la necesidad de expresar emociones positivas como parte del trabajo policial. Haber completado la escuela secundaria, ser Cabo y actuar en el servicio extremo también fueron predictores de burnout. Las evidencias del impacto del trabajo emocional y del cargo en la incidencia de burnout ponen en evidencia la importancia de dar atención especial a la salud y al desarrollo de competencias socioemocionales de policías militares

  4. Mejorar el trabajo en equipo: ambidiestría, comportamiento integrador y aprendizaje cooperativo

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    María Iborra

    2012-09-01

    Full Text Available El objetivo de este estudio es argumentar y demostrar qué trabajo en equipo deben aprender los futuros profesionales de la dirección de empresas y cómo pueden aprenderlo. Respecto a las características del trabajo en equipo que deben aprender los futuros directivos, se argumenta que un comportamiento integrador permite alcanzar mayores niveles de ambidiestría, es decir, incrementar la capacidad de realizar simultáneamente exploración y explotación de conocimiento, eficiencia e innovación. El estudio profundiza en la relación entre las metodologías docentes utilizadas en el aula y la mejora del comportamiento integrador de los profesionales cuando trabajan en equipo. El comportamiento integrador en un equipo depende de la calidad y cantidad de información intercambiada, la colaboración alcanzada en el equipo, y la medida en que las decisiones se toman conjuntamente. En este trabajo se defiende la relación positiva entre la metodología docente de aprendizaje cooperativo y el comportamiento integrador de los estudiantes en los equipos de trabajo. Mediante un estudio realizado con 327 estudiantes de enseñanza universitaria, se demuestra que los equipos de trabajo que han utilizado aprendizaje cooperativo alcanzan mayores niveles de comportamiento integrador. Igualmente se demuestra que el comportamiento integrador de los miembros del equipo se asocia con una superior ambidiestría.

  5. Blood Gene Expression Profiling of Breast Cancer Survivors Experiencing Fibrosis

    International Nuclear Information System (INIS)

    Landmark-Hoyvik, Hege; Dumeaux, Vanessa; Reinertsen, Kristin V.; Edvardsen, Hege; Fossa, Sophie D.; Borresen-Dale, Anne-Lise

    2011-01-01

    Purpose: To extend knowledge on the mechanisms and pathways involved in maintenance of radiation-induced fibrosis (RIF) by performing gene expression profiling of whole blood from breast cancer (BC) survivors with and without fibrosis 3-7 years after end of radiotherapy treatment. Methods and Materials: Gene expression profiles from blood were obtained for 254 BC survivors derived from a cohort of survivors, treated with adjuvant radiotherapy for breast cancer 3-7 years earlier. Analyses of transcriptional differences in blood gene expression between BC survivors with fibrosis (n = 31) and BC survivors without fibrosis (n = 223) were performed using R version 2.8.0 and tools from the Bioconductor project. Gene sets extracted through a literature search on fibrosis and breast cancer were subsequently used in gene set enrichment analysis. Results: Substantial differences in blood gene expression between BC survivors with and without fibrosis were observed, and 87 differentially expressed genes were identified through linear analysis. Transforming growth factor-β1 signaling was identified as the most significant gene set, showing a down-regulation of most of the core genes, together with up-regulation of a transcriptional activator of the inhibitor of fibrinolysis, Plasminogen activator inhibitor 1 in the BC survivors with fibrosis. Conclusion: Transforming growth factor-β1 signaling was found down-regulated during the maintenance phase of fibrosis as opposed to the up-regulation reported during the early, initiating phase of fibrosis. Hence, once the fibrotic tissue has developed, the maintenance phase might rather involve a deregulation of fibrinolysis and altered degradation of extracellular matrix components.

  6. Accuracy of FibroScan for diagnosing liver fibrosis

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    Jian ZHANG

    2011-11-01

    Full Text Available Objective To evaluate the accuracy of transient elastometry(FibroScan for the detection of liver fibrosis.Methods A total of 323 patients diagnosed with chronic liver disease based on pathological examination in the 302 Hospital of the People’s Liberation Army from April to December of 2009 were involved in the current study.Among them,141 patients were subjected to liver biopsy.Their liver function,coagulant index,B-ultrasound and blood cell count were examined clinically.Four examinations related to liver fibrosis were done on some of the patients.Meanwhile,FibroScan was used for liver stiffness measurement(LSM of every patient.The correlation between liver stiffness and the serologic index and liver fibrosis degree was analyzed.The Receive Operating Characteristic(ROC curve was adopted to analyze the accuracy of FibroScan for diagnosing liver fibrosis.Results Each serologic index was significantly correlated with liver stiffness(P < 0.001,and liver stiffness was closely related to the stage of liver fibrosis(r=0.74,P < 0.001.The statistical results of the 141 patients who underwent pathologic examination show that the areas under the ROC curve were 0.97(0.94,1.00 for patients with portal fibrosis(F1,0.96(0.93,0.99 for patients with significant fibrosis(F2,0.99(0.98,1.00 for patients with severe fibrosis(F3,and 0.97(0.94,0.99 for patients with cirrhosis(F4.The cutoff values were 4.4KPa,6.8KPa,9.7KPa,and 10.0KPa,respectively.Conclusion FibroScan is valuable for the diagnosis of liver fibrosis.It can be used as the basis for follow-up and management of patients with chronic liver diseases.

  7. Impaired Lymphocyte Profile in Schistosomiasis Patients with Periportal Fibrosis

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    Luciana Santos Cardoso

    2013-01-01

    Full Text Available The Th2 immune response in chronic schistosomiasis is associated with the development of periportal fibrosis. However, little is known about the phenotype and activation status of T cells in the process. Objective. To evaluate the profile of T cells in schistosomiasis patients with periportal fibrosis. Methods. It was a cross-sectional study, conducted in the village of Agua Preta, Bahia, Brazil, which included 37 subjects with periportal fibrosis determined by ultrasound. Peripheral blood mononuclear cells were obtained by the Ficcol-hypaque gradient and the frequency of T cells expressing the surface markers CD28, CD69, CD25, and CTLA-4 was determined by flow cytometry. Results. The frequency of CD4+CD28+ T lymphocytes was higher in individuals with moderate to severe fibrosis compared to patients with incipient fibrosis. We did not observe any significant difference in the frequency of CD4+ T cells expressing CD69 among groups of individuals. There was also no significant difference in the frequency of CD8+ T cells expressing CD28 or CD69 among the studied groups. Individuals with moderate to severe fibrosis presented a lower frequency of CD8+ T cells, CD4+CD25high T cells, and CD4+CTLA-4+ T cells when compared to patients without fibrosis or incipient fibrosis. The frequency of CD4+CD25low cells did not differ between groups. Conclusion. The high frequency of activated T cells coinciding with a low frequency of putative Treg cells may account for the development of periportal fibrosis in human schistosomiasis.

  8. Ormond's disease or secondary retroperitoneal fibrosis? An overview of retroperitoneal fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Heckmann, M.; Uder, M.; Kuefner, M.A.; Heinrich, M.C. [Universitaetsklinikum Erlangen (Germany). Radiologisches Inst.

    2009-04-15

    Retroperitoneal fibrosis represents a rare inflammatory disease. About two thirds of all cases seem to be idiopathic (= Ormond's disease). The remaining one third is secondary and may be ascribed to infections, trauma, radiation therapy, malignant diseases, and the use of certain drugs. Up to 15 % of patients have additional fibrotic processes outside the retroperitoneum. The clinical symptoms of retroperitoneal fibrosis are non-specific. In sonography retroperitoneal fibrosis appears as a retroperitoneal hypoechoic mass which can involve the ureters and thus cause hydronephrosis. Intravenous urography and MR urography can demonstrate the typical triad of medial deviation and extrinsic compression of the ureters and hydronephrosis. CT and MRI are the modalities of choice for the diagnosis and follow-up of this disease. The lesion typically begins at the level of the fourth or fifth lumbar vertebra and appears as a plaque, encasing the aorta and the inferior vena cava and often enveloping and medially displacing the ureters. In unenhanced CT, retroperitoneal fibrosis appears as a mass that is isodense with muscle. When using MRI, the mass is hypointense in T1-weighted images and of variable intensity in T2-weighted images according to its stage: it may be hyperintense in early stages, while the tissue may have a low signal in late stages. After the administration of contrast media, enhancement is greatest in the early inflammatory phase and minimal in the late fibrotic phase. Dynamic gadolinium enhancement can be useful for assessing disease activity, monitoring response to treatment, and detecting relapse. To differentiate retroperitoneal masses, diffusion-weighted MRI may provide useful information. (orig.)

  9. Quantitative immunoassays for diagnosis and carrier detection in cystic fibrosis

    International Nuclear Information System (INIS)

    Bullock, S.; Hayward, C.; Manson, J.; Brock, D.J.H.; Raeburn, J.A.

    1982-01-01

    Quantitative immunoprecipitation and immunoradiometric assays have been developed for a protein present in the serum of cystic fibrosis homozygotes, and to a lesser extent in the serum of heterozygotes. When tested on a panel of sera from 14 cystic fibrosis patients, 29 heterozygotes and 23 controls, the immunoprecipitation assay allowed correct assignments to be made on 94% of occasions with one batch of antiserum and 95% with another. With the same panel of sera, the immunoradiometric assay allowed 94% correct assignments. It is suggested that such accuracy is the maximum that can be expected in the present state of knowledge of cystic fibrosis. (author)

  10. Epithelial-mesenchymal transition: An emerging target in tissue fibrosis

    Science.gov (United States)

    Li, Meirong; Luan, Fuxin; Zhao, Yali; Hao, Haojie; Zhou, Yong; Han, Weidong

    2016-01-01

    Epithelial-mesenchymal transition (EMT) is involved in a variety of tissue fibroses. Fibroblasts/myofibroblasts derived from epithelial cells contribute to the excessive accumulation of fibrous connective tissue in damaged tissue, which can lead to permanent scarring or organ malfunction. Therefore, EMT-related fibrosis cannot be neglected. This review highlights the findings that demonstrate the EMT to be a direct contributor to the fibroblast/myofibroblast population in the development of tissue fibrosis and helps to elucidate EMT-related anti-fibrotic strategies, which may enable the development of therapeutic interventions to suppress EMT and potentially reverse organ fibrosis. PMID:26361988

  11. Evaluación nutricional dietética en pacientes afectos de fibrosis quística Dietetic nutritional assessment in patients with cystic fibrosis

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    Aida E. Esplugas Montoya

    2008-09-01

    Full Text Available INTRODUCCIÓN. La fibrosis quística es una enfermedad hereditaria de transmisión autosómica recesiva, que afecta a las células epiteliales exocrinas, y los órganos más afectados son el páncreas y los pulmones. La esteatorrea es la más importante manifestación clínica y afecta al estado nutritivo, al desarrollo y a la absorción de micronutrientes y vitaminas liposolubles. Mantener un estado nutricional adecuado es un aspecto decisivo en el tratamiento de estos pacientes. El objetivo de este trabajo fue caracterizar el estado nutricional dietético de niños que se encuentran en situaciones de riesgo nutricional. MÉTODOS. Se realizó un estudio descriptivo con un grupo de pacientes afectos de fibrosis quística. El universo comprendió 17 pacientes que recibieron atención médica y seguimiento en el Hospital Pediátrico Docente "William Soler". RESULTADOS. En la encuesta se encontró que la distribución porcentual calórica que aportaron los alimentos consumidos por los pacientes fue del 12 % para las proteínas, del 33 % para las grasas y del 55 % para los carbohidratos. La energía que aportaron los alimentos consumidos ascendió a 3400 kcal, con un intervalo mínimo de 1703 kcal y máximo de 6180 kcal. Para las proteínas el consumo fue de 101 g, con un rango de 49 a 207 g; para las grasas fue de 128 g, con rango de 60 g a 270 g y para los carbohidratos, 457 g con intervalo mínimo de 243 g e intervalo máximo de 704 g. CONCLUSIONES. La evaluación dietética de un niño puede predecir la alteración de su estado nutricional antes de la alteración bioquímica y mucho antes de que se hagan evidentes los signos clínicos de deficiencia.INTRODUCTION: Cystic fibrosis is a hereditary disease of recessive autosomal transmission, affecting the exocrine epithelial cells. The most affected organs are pancreas and lungs. Steatorrhea is the most significant clinical manifestation affecting the nutritional status, development and the

  12. Derechos laborales: una mirada al derecho a la calidad de vida en el trabajo

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    Juana Patlán Pérez

    2016-01-01

    Full Text Available Se tiene como objetivo sustentar la calidad de vida en el trabajo como un derecho humano laboral que repercute en la salud ocupacional de los trabajadores. La calidad de vida en el trabajo es un constructo multidimensional y complejo que hace referencia principalmente a la satisfacción de una amplia gama de necesidades de los individuos (reconocimiento, estabilidad laboral, equilibrio empleo-familia, motivación, seguridad, entre otros mediante un trabajo formal y remunerado. Para este propósito, se efectuó una revisión a la literatura, definiéndose a la calidad de vida laboral en dieciocho dimensiones que, en conjunto, contribuyen a la satisfacción de necesidades a las que hace referencia este constructo.

  13. EL TRABAJO INVISIBLE DE MENORES DE BAZURTO. MERCADO CENTRAL DE CARTAGENA DE INDIAS

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    Hortensia Naizarra Rodriguez

    2000-08-01

    Full Text Available A un cuando la motivación principal del trabajo infanto juvenil sigue siendo la ayuda a la familia, hay factores de orden cultural que 10 propician. Para las familias de origen rural el trabajo infantil está relacionado con la imagen del menor como símbolo y unidad económica de producción ya que existe la creencia entre los padres que los niños son veloces, ágiles, tienen mucha destreza y voluntad para cierto tipo de trabajo, y por tanto se convierten en una ayuda; pero tras esta denominada ayuda lo que se observa es una carga de responsabilidades que deterioran física, social y emocionalmente al menor y disminuyen ostensiblemente sus opciones de desarrollo humano.

  14. Estudio transversal de los determinantes del trabajo infantil en Cartagena, año 2007

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    Karina Acevedo

    2011-01-01

    Full Text Available El trabajo infantil constituye una problemática compleja que tiene importantes repercusiones en las reservas de capital humano, en la salud de los niños y niñas, y en la persistencia de la pobreza. Nuestro principal objetivo en este artículo es dilucidar sus determinantes en la ciudad de Cartagena a través de la estimación de un modelo probit bivariado, con el cual analizamos conjuntamente las decisiones de trabajo y de asistencia escolar. Los resultados muestran que el trabajo infantil y la asistencia escolar son actividades excluyentes, siendo los determinantes más robustos de estas decisiones la educación del jefe de hogar, y la pobreza. Entre otros determinantes se encuentran las restricciones crediticias, la proximidad física a las escuelas y la tasa de ocupación de las personas adultas.

  15. Significados sobre el trabajo para parejas en situación de desempleo masculino

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    Ernesto Martín Padilla

    2012-01-01

    Full Text Available El objetivo del artículo es comprender los significados que las parejas en convivencia desarrollan sobre el trabajo a partir del desempleo del hombre. Esta reflexión surge de un estudio cualitativo de tipo social interpretativo; se hicieron entrevistas a ocho parejas de poblaciones de la sabana de Bogotá con la técnica de grupo focal. Los resultados señalan que las restricciones económicas y la dificultad para obtener empleo generan un interés principalmente económico en el trabajo. Hay una débil identidad personal con el trabajo, ya que este es visto como un factor que trae implicaciones como la pérdida de espacios para compartir en familia. Esto, unido a la dificultad para reengancharse, afecta la valoración del empleo como fuente de satisfacción y desarrollo.

  16. Entre puertos, campos y acopios: Trabajo y transporte de granos en torno al Sudeste bonaerense.

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    Paula Tagliabue

    2014-12-01

    Full Text Available En este artículo, se analiza el proceso de trabajo en el transporte automotor de granos en torno al sudeste bonaerense. Desde un abordaje cualitativo, se describen y analizan las prácticas durante la cosecha y pos-cosecha, y los trayectos campo-acopio, acopio-puerto. También se analizan las relaciones laborales a partir de una perspectiva ampliada de las relaciones laborales clásicas (asalariadas, estables, protegidas.Los rasgos que asume el trabajo en el transporte de granos están asociados a los cambios técnicos y tecnológicos de la producción de granos, así como a procesos de flexibilización laboral, vinculados a la disponibilidad permanente para fletar, la extensión de la jornada laboral y la intensidad del trabajo camionero.

  17. Plan de clase para la enseñanza de la integral del trabajo

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    Jorge Flores

    2014-06-01

    Full Text Available El propósito de este trabajo fue presentar un plan de clase, fundamentado en la Teoría Conceptual Combinada de Gilles Fauconnier y Mark Turner, para enseñar la integral del trabajo, siguiendo el modelo instruccional de Robert Gagné. Para el diseño de esta clase se utilizó la red de integración conceptual entre la integral de una función, dominio de la Matemática y la integral del trabajo, dominio de la Física. Luego se diseñó el plan de clase, el cual se fundamenta en la presentación y evaluación de la instrucción y su correspondiente retroalimentación.

  18. Algoritmo para el cálculo de cargas de trabajo

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    Mauricio Becerra Fernández

    2016-04-01

    Full Text Available Este artículo presenta el desarrollo un algoritmo para el cálculo de cargas de trabajo, soportado en el análisis de estudios similares y la teoría del estudio de métodos y tiempos. El algoritmo se propone como un elemento de soporte para el análisis del nivel trabajo asignado a un cargo específico o a un grupo de trabajadores en un área determinada, ya sea en la industria de manufactura o de servicios, lo que permita nivelar el volumen de trabajo asignado mediante la definición de diversas alternativas que promuevan el aumento de la productividad, favorezcan la mejora en el clima y las condiciones laborales.

  19. Trabajo infantil, pobreza y desarrollo local en el municipio de Buenaventura. Un estudio de caso

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    Oscar Jehiny Larrahondo Ramos

    2010-01-01

    Full Text Available El presente texto es el resultado del estudio denominado “Trabajo infantil y factores de vulnerabilidad en Buenaventura”, el cual describe y perfila algunas consideraciones sobre el trabajo infantil y su relación con la pobreza y el Desarrollo Local en el municipio de Buenaventura en el año 2010, a partir de cinco espacios de interrelación laboral en los que se presenta la problemática. Aquí, se muestran algunas definiciones conceptuales pertinentes sobre el Trabajo Infantil y la Pobreza, al igual que una serie de hallazgos, al mismo tiempo que un conjunto de recomendaciones o conclusiones al respecto.

  20. Escalamiento y trabajo: El caso de la industria electrónica de Tijuana

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    Ricardo López Salazar

    2010-01-01

    Full Text Available En este trabajo se analizará la incidencia del escalamiento industrial en el trabajo de tres empresas maquiladoras del sector electrónico ubicadas en Tijuana, México. Los resultados arrojan que las tres empresas escalaron en producto y funciones, gracias al impulso del Tratado de Libre Comercio de América del Norte (tlcan, al aprovechamiento de las capacidades internas y al apoyo otorgado por sus respectivos corporativos. Por su parte, los trabajadores calificados (ingenieros y gerentes experimentan un proceso de revaloración, derivado de su conocimiento adquirido a lo largo de amplias trayectorias laborales dentro de las empresas. Como resultado, el escalamiento industrial de las tres plantas estudiadas está asociado a mejoras laborales debido a la alta estabilidad en el empleo, lo que permite la implementación de planes de carrera, capacitaciones de alto nivel y certificaciones en el trabajo.