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  1. Uso de vitamina C en la solución tumescente de liposucción como inductor de lipolisis y fibrosis: Trabajo experimental Use of vitamine C in liposuction tumescent solution as lipolisis and fibrosis inductor: Experimental study

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    N. Antoniadis Petrakis

    2007-06-01

    Full Text Available La Liposucción no permite siempre extraer todo el tejido adiposo causante de la lipodistrofia, por lo cual se plantea la necesidad de perfeccionar esta técnica. Nuestro objetivo es el demostrar que el uso de la vitamina C en la solución tumescente induce lipólisis y aumenta la fibrosis. El presente es un estudio descriptivo, prospectivo, experimental y comparativo de una muestra de 30 ratas Sprague-Dawley de ambos sexos, a las cuales se les infiltró solución tumescente en el tejido subdérmico de la región inguinal, con vitamina C al grupo experimental y con solución tumescente sin vitamina C al grupo control, para su posterior estudio histológico macroscópico y microscópico. El 100% de las muestras con vitamina C evidenciaron cambios a nivel del tejido adiposo sugerentes de lipólisis y en el 82% se evidenciaron cambios en el tejido conectivo sugerentes de formación de colágeno joven. Concluimos que la vitamina C favorece la lipolisis y promueve la síntesis de colágeno cuando se utiliza como parte de la solución tumescente en animales de experimentaciónLiposuction does not always let to remove all the amount of adipose tissue which causes lipodistrophy, for that reason, it is recommended the necessity to improve that technique. We try to demonstrate that the use of vitamin C in the tumescence solution induces lipolysis and raises fibrosis. This article is a descriptive, prospective, experimental and comparative research of a sample of 30 mice of Sprague- Dawley type of both sexes, which were infiltrated with a tumescence solution in the subdermic inguinal region with vitamin C to the experimental group and with tumescence solution without vitamin C to the control group, for a further histological macroscopic as well as microscopic study. The results showed that 100% of the samples with vitamin C presented changes in the adipose tissue which suggested lipolysis, whereas 82% were evidence for the formation of young collagen. As a

  2. Therapy of experimental NASH and fibrosis with galectin inhibitors.

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    Peter G Traber

    Full Text Available Non-alcoholic steatohepatitis (NASH and resultant liver fibrosis is a major health problem without effective therapy. Some data suggest that galectin-3 null mice are resistant to the development of NASH with fibrosis. We examined the ability of two complex carbohydrate drugs that bind galectin-3, GM-CT-01 and GR-MD-02, to treat NASH with fibrosis in a murine model. GR-MD-02 treatment resulted in marked improvement in liver histology with significant reduction in NASH activity and collagen deposition. Treatments seemed also to improve both glomerulopathy and interstitial fibrosis observed in kidneys. The improvement in liver histology was evident when animals were treated early in disease or after establishment of liver fibrosis. In all measures, GM-CT-01 had an intermediate effect between vehicle and GR-MD-02. Galectin-3 protein expression was increased in NASH with highest expression in macrophages surrounding lipid laden hepatocytes, and reduced following treatment with GR-MD-02, while the number of macrophages was unchanged. Treatment with GR-MD-02 also reduced the expression of pathological indicators including iNOS, an important TH1 inflammatory mediator, CD36, a scavenger receptor for lipoproteins on macrophages, and α-smooth muscle actin, a marker for activated stellate cells which are the primary collagen producing cells in liver fibrosis. We conclude that treatment with these galectin-3 targeting drugs improved histopathological findings of NASH and markedly reduced fibrosis in a murine model of NASH. While the mechanisms require further investigation, the treatment effect is associated with a reduction of galectin-3 expressed by activated macrophages which was associated with regression of NASH, including hepatocellular fat accumulation, hepatocyte ballooning, intra-portal and intra-lobular inflammatory infiltrate, and deposition of collagen. Similar effects were found with GM-CT-01, but with approximately four-fold lower potency than

  3. Experimental induction of pulmonary fibrosis in horses with the gammaherpesvirus equine herpesvirus 5.

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    Williams, Kurt J; Robinson, N Edward; Lim, Ailam; Brandenberger, Christina; Maes, Roger; Behan, Ashley; Bolin, Steven R

    2013-01-01

    Gammaherpesviruses (γHV) are implicated in the pathogenesis of pulmonary fibrosis in humans and murine models of lung fibrosis, however there is little direct experimental evidence that such viruses induce lung fibrosis in the natural host. The equine γHV EHV 5 is associated with equine multinodular pulmonary fibrosis (EMPF), a progressive fibrosing lung disease in its natural host, the horse. Experimental reproduction of EMPF has not been attempted to date. We hypothesized that inoculation of EHV 5 isolated from cases of EMPF into the lungs of clinically normal horses would induce lung fibrosis similar to EMPF. Neutralizing antibody titers were measured in the horses before and after inoculation with EHV 5. PCR and virus isolation was used to detect EHV 5 in antemortem blood and BAL samples, and in tissues collected postmortem. Nodular pulmonary fibrosis and induction of myofibroblasts occurred in EHV 5 inoculated horses. Mean lung collagen in EHV 5 inoculated horses (80 µg/mg) was significantly increased compared to control horses (26 µg/mg) (p < 0.5), as was interstitial collagen (32.6% ± 1.2% vs 23% ± 1.4%) (mean ± SEM; p < 0.001). Virus was difficult to detect in infected horses throughout the experiment, although EHV 5 antigen was detected in the lung by immunohistochemistry. We conclude that the γHV EHV 5 can induce lung fibrosis in the horse, and hypothesize that induction of fibrosis occurs while the virus is latent within the lung. This is the first example of a γHV inducing lung fibrosis in the natural host.

  4. Experimental induction of pulmonary fibrosis in horses with the gammaherpesvirus equine herpesvirus 5.

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    Kurt J Williams

    Full Text Available Gammaherpesviruses (γHV are implicated in the pathogenesis of pulmonary fibrosis in humans and murine models of lung fibrosis, however there is little direct experimental evidence that such viruses induce lung fibrosis in the natural host. The equine γHV EHV 5 is associated with equine multinodular pulmonary fibrosis (EMPF, a progressive fibrosing lung disease in its natural host, the horse. Experimental reproduction of EMPF has not been attempted to date. We hypothesized that inoculation of EHV 5 isolated from cases of EMPF into the lungs of clinically normal horses would induce lung fibrosis similar to EMPF. Neutralizing antibody titers were measured in the horses before and after inoculation with EHV 5. PCR and virus isolation was used to detect EHV 5 in antemortem blood and BAL samples, and in tissues collected postmortem. Nodular pulmonary fibrosis and induction of myofibroblasts occurred in EHV 5 inoculated horses. Mean lung collagen in EHV 5 inoculated horses (80 µg/mg was significantly increased compared to control horses (26 µg/mg (p < 0.5, as was interstitial collagen (32.6% ± 1.2% vs 23% ± 1.4% (mean ± SEM; p < 0.001. Virus was difficult to detect in infected horses throughout the experiment, although EHV 5 antigen was detected in the lung by immunohistochemistry. We conclude that the γHV EHV 5 can induce lung fibrosis in the horse, and hypothesize that induction of fibrosis occurs while the virus is latent within the lung. This is the first example of a γHV inducing lung fibrosis in the natural host.

  5. Renal Fibrosis mRNA Classifier: Validation in Experimental Lithium-Induced Interstitial Fibrosis in the Rat Kidney.

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    Marti, Hans-Peter; Jeffs, Aaron; Scherer, Andreas; Leader, John; Leader, Catherine; Bedford, Jennifer; Walker, Robert

    2016-01-01

    Accurate diagnosis of fibrosis is of paramount clinical importance. A human fibrosis classifier based on metzincins and related genes (MARGS) was described previously. In this investigation, expression changes of MARGS genes were explored and evaluated to examine whether the MARGS-based algorithm has any diagnostic value in a rat model of lithium nephropathy. Male Wistar rats (n = 12) were divided into 2 groups (n = 6). One group was given a diet containing lithium (40 mmol/kg food for 7 days, followed by 60mmol/kg food for the rest of the experimental period), while a control group (n = 6) was fed a normal diet. After six months, animals were sacrificed and the renal cortex and medulla of both kidneys removed for analysis. Gene expression changes were analysed using 24 GeneChip® Affymetrix Rat Exon 1.0 ST arrays. Statistically relevant genes (p-value1.5, t-test) were further examined. Matrix metalloproteinase-2 (MMP2), CD44, and nephroblastoma overexpressed gene (NOV) were overexpressed in the medulla and cortex of lithium-fed rats compared to the control group. TGFβ2 was overrepresented in the cortex of lithium-fed animals 1.5-fold, and 1.3-fold in the medulla of the same animals. In Gene Set Enrichment Analysis (GSEA), both the medulla and cortex of lithium-fed animals showed an enrichment of the MARGS, TGFβ network, and extracellular matrix (ECM) gene sets, while the cortex expression signature was enriched in additional fibrosis-related-genes and the medulla was also enriched in immune response pathways. Importantly, the MARGS-based fibrosis classifier was able to classify all samples correctly. Immunohistochemistry and qPCR confirmed the up-regulation of NOV, CD44, and TGFβ2. The MARGS classifier represents a cross-organ and cross-species classifier of fibrotic conditions and may help to design a test to diagnose and to monitor fibrosis. The results also provide evidence for a common pathway in the pathogenesis of fibrosis.

  6. Comparison of Oxiplex and Gore-Tex effectivity in an experimental peridural fibrosis model.

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    Kurt, G; Cemil, B; Celik, B; Durdag, E; Erdem, O; Ceviker, N

    2009-08-01

    The authors conducted a study to compare the effectiveness of Oxiplex and Gore-tex in preventing postlaminectomy peridural fibrosis in rats. Peridural fibrosis is a common cause of pain in patients undergoing spinal surgery. To prevent scar formation numerous materials and methods have been employed such as non steroidal anti-inflammatory drugs (NSAIDs), Gelfoam, Oxiplex, Gore-tex, carboxymethil cellulose, Adcon-L, autogenous adipose grefting, mitomisin, and radiotherapy have been investigating for a long time, but only moderate success has been obtained. Laminectomies were performed at the fourth lumbar vertebra (L-4) in 30 rats. Oxiplex or Gore-Tex was applied over the dura mater with the aim to perform a blinded evaluation of their effects. In the control group, only a L-4 laminectomy was performed. Animals were sacrificed 28 days after the surgical procedure. The extent of peridural fibrosis was evaluated on spine specimens by histological analysis. Both groups of animals treated with either Oxiplex or Gore-Tex showed a significant reduction in the degree of peridural fibrosis as compared to the control group. However no significant difference in the prevention of peridural fibrosis was observed between the Oxiplex and Gore-Tex groups. This experimental model has shown that Oxiplex and Gore-Tex are effective methods to prevent peridural fibrosis and dural adhesions at the postlaminectomy areas.

  7. Experimental liver fibrosis research: update on animal models, legal issues and translational aspects

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    2013-01-01

    Liver fibrosis is defined as excessive extracellular matrix deposition and is based on complex interactions between matrix-producing hepatic stellate cells and an abundance of liver-resident and infiltrating cells. Investigation of these processes requires in vitro and in vivo experimental work in animals. However, the use of animals in translational research will be increasingly challenged, at least in countries of the European Union, because of the adoption of new animal welfare rules in 2013. These rules will create an urgent need for optimized standard operating procedures regarding animal experimentation and improved international communication in the liver fibrosis community. This review gives an update on current animal models, techniques and underlying pathomechanisms with the aim of fostering a critical discussion of the limitations and potential of up-to-date animal experimentation. We discuss potential complications in experimental liver fibrosis and provide examples of how the findings of studies in which these models are used can be translated to human disease and therapy. In this review, we want to motivate the international community to design more standardized animal models which might help to address the legally requested replacement, refinement and reduction of animals in fibrosis research. PMID:24274743

  8. Reduction of epidural fibrosis and dural adhesions after lamina reconstruction by absorbable cement: an experimental study.

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    Zeinalizadeh, Mehdi; Miri, Seyed Mojtaba; Ardalan, Farid Azmoodeh; Maleki, Farid; Zakeri, Marjan; Aghajanzadeh, Elham; Habibi, Zohreh

    2014-01-01

    Post-laminectomy epidural fibrosis complicates revision spine surgery and is implicated in cases of "failed back syndrome." Several materials have been used to minimize epidural fibrosis with varying results. The aim of this study was to examine the impact of reconstruction of laminectomy site with a type of absorbable cement (Jectos) to reduce epidural fibrosis. This investigation is an experimental controlled study, which is designed to evaluate the preventive effects of laminectomy site reconstruction in rat laminectomy model. Twenty wistar rats were included in this study and divided randomly to two equal groups, namely, subject and control. In both groups, laminectomy was performed in L2 and L4 levels. Control group received no additional treatment. In the subject group, L4 levels were reconstructed by Jectos and L2 levels were non-reconstructed as internal controls. Six months after surgery the rats were sacrificed and the dural adhesion and epidural fibrosis were evaluated macroscopically and microscopically. The study was financially supported by Brain and Spinal Cord Injuries Repair Center. None of the authors have any conflict of interest. Non-reconstructed levels in both groups showed dense epidural fibrosis with marked dural adherence. L4 reconstructed levels in subject group showed reduced epidural fibrosis macroscopically (p=.024) and microscopically (p=.041). No foreign body reaction or ossification occurred at reconstructed sites. In the present study, lamina reconstruction with absorbable cement was a safe method that significantly reduced post-laminectomy epidural fibrosis and dural adhesions in rat laminectomy model. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis

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    Bramanti Placido

    2011-04-01

    Full Text Available Abstract Background Adrenomedullin (AM, a 52-amino acid ringed-structure peptide with C-terminal amidation, was originally isolated from human pheochromocytoma. AM are widely distributed in various tissues and acts as a local vasoactive hormone in various conditions. Methods In the present study, we investigated the efficacy of AM on the animal model of bleomycin (BLM-induced lung injury. Mice were subjected to intratracheal administration of BLM and were assigned to receive AM daily by an intraperitoneal injection of 200 ngr/kg. Results and Discussion Myeloperoxidase activity, lung histology, immunohistochemical analyses for cytokines and adhesion molecules expression, inducible nitric oxide synthase (iNOS, nitrotyrosine, and poly (ADP-ribose polymerase (PARP were performed one week after fibrosis induction. Lung histology and transforming growth factor beta (TGF-β were performed 14 and 21 days after treatments. After bleomycin administration, AM-treated mice exhibited a reduced degree of lung damage and inflammation compared with BLM-treated mice, as shown by the reduction of (1 myeloperoxidase activity (MPO, (2 cytokines and adhesion molecules expression, (3 nitric oxide synthase expression, (4 the nitration of tyrosine residues, (5 poly (ADP-ribose (PAR formation, a product of the nuclear enzyme poly (ADP-ribose polymerase (PARP (6 transforming growth factor beta (TGF-β (7and the degree of lung injury. Conclusions Our results indicate that AM administration is able to prevent bleomycin induced lung injury through the down regulation of proinflammatory factors.

  10. Protocatechuic aldehyde ameliorates experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway

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    Zhang, Liang, E-mail: countryspring@sina.com; Ji, Yunxia, E-mail: 413499057@qq.com; Kang, Zechun, E-mail: davidjiangwl@163.com; Lv, Changjun, E-mail: Lucky_lcj@sina.com; Jiang, Wanglin, E-mail: jwl518@163.com

    2015-02-15

    An abnormal high mobility group box 1 (HMGB1) activation and a decrease in receptor for advanced glycation end-product (RAGE) play a key role in the pathogenesis of pulmonary fibrosis. Protocatechuic aldehyde (PA) is a naturally occurring compound, which is extracted from the degradation of phenolic acids. However, whether PA has anti-fibrotic functions is unknown. In this study, the effects of PA on the transforming growth factor-β1 (TGF-β1)-mediated epithelial–mesenchymal transition (EMT) in A549 cells, on the apoptosis of human type I alveolar epithelial cells (AT I), on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on bleomycin (BLM)-induced pulmonary fibrosis in vivo were investigated. PA treatment resulted in a reduction of EMT in A549 cells with a decrease in vimentin and HMGB, an increase of E-cadherin and RAGE, a reduction of HLF-1 proliferation with a decrease of fibroblast growth factor 2 (FGF-2) and platelet-derived growth factor (PDGF). Apoptosis of AT I was attenuated with an increase of RAGE. PA ameliorated BLM-induced pulmonary fibrosis in rats with a reduction of histopathological scores and collagen deposition, and a lower FGF-2, PDGF, α-smooth muscle actin (α-SMA) and HMGB1 expression, whereas higher RAGE was found in BLM-instilled lungs. Through the decrease of HGMB1 and the regulation of RAGE, PA reversed the EMT, inhibited HLF-1 proliferation as well as reduced apoptosis in AT I, and prevented pulmonary fibrosis in vivo. Collectively, our results demonstrate that PA prevents experimental pulmonary fibrosis by modulating HMGB1/RAGE pathway. - Highlights: • PA prevents EMT, reduces the apoptosis of AT1 in vitro. • PA decreases proliferation of HLF-1, reduces PDGF and FGF expression in vitro. • PA prevents experimental pulmonary fibrosis by modulating the HMGB1/RAGE pathway.

  11. The Effects of Rifampin, Povidone-Iodine and Hydrogen Peroxide on the Formation of Epidural Fibrosis in the Experimental Epidural Fibrosis Model.

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    Kizilay, Zahir; Cetin, Nesibe Kahraman; İsmailoglu, Özgur; Yılmaz, Ali; Omurlu, İmran Kurt; Coskun, Mehmet Erdal; Aktaş, Serdar

    2016-08-01

    The aim of the study was to determine the effect of direct application of rifampin, povidone-iodine, and hydrogen peroxide on the formation of epidural fibrosis in rats. Forty-eight adult male Wistar albino rats were equally and randomly divided into four groups (laminectomy, topical rifampin, topical povidone-iodine, and topical hydrogen peroxide). Laminectomy was performed at the T12 level in all rats. Four weeks later, the extent of epidural fibrosis was assessed both macroscopically and histopathologically. ANOVA test was used for the evaluation of dural thickness. Kruskal-Wallis test was used for the pathology and macroscopic evaluation. Chi-square test was used for evaluation of the arachnoid involvement. p value hydrogen peroxide were effective in reducing epidural fibrosis formation. The results of our study provide the experimental evidence of the preventive effects of topical application of povidone-iodine and hydrogen peroxide over epidural fibrosis.

  12. Protective roles of pulmonary rehabilitation mixture in experimental pulmonary fibrosis in vitro and in vivo

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    Zhang, L.; Ji, Y.X.; Jiang, W.L.; Lv, C.J.

    2015-01-01

    Abnormal high mobility group protein B1 (HMGB1) activation is involved in the pathogenesis of pulmonary fibrosis. Pulmonary rehabilitation mixture (PRM), which combines extracts from eight traditional Chinese medicines, has very good lung protection in clinical use. However, it is not known if PRM has anti-fibrotic activity. In this study, we investigated the effects of PRM on transforming growth factor-β1 (TGF-β1)-mediated and bleomycin (BLM)-induced pulmonary fibrosis in vitro and in vivo. The effects of PRM on TGF-β1-mediated epithelial-mesenchymal transition (EMT) in A549 cells, on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on BLM-induced pulmonary fibrosis in vivo were investigated. PRM treatment resulted in a reduction of EMT in A549 cells that was associated with attenuating an increase of vimentin and a decrease of E-cadherin. PRM inhibited the proliferation of HLF-1 at an IC 50 of 0.51 µg/mL. PRM ameliorated BLM-induced pulmonary fibrosis in rats, with reduction of histopathological scores and collagen deposition, and a decrease in α-smooth muscle actin (α-SMA) and HMGB1 expression. An increase in receptor for advanced glycation end-product (RAGE) expression was found in BLM-instilled lungs. PRM significantly decreased EMT and prevented pulmonary fibrosis through decreasing HMGB1 and regulating RAGE in vitro and in vivo. PRM inhibited TGF-β1-induced EMT via decreased HMGB1 and vimentin and increased RAGE and E-cadherin levels. In summary, PRM prevented experimental pulmonary fibrosis by modulating the HMGB1/RAGE pathway

  13. Protective roles of pulmonary rehabilitation mixture in experimental pulmonary fibrosis in vitro and in vivo

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    Zhang, L.; Ji, Y.X.; Jiang, W.L.; Lv, C.J. [School of Pharmaceutical Sciences, Binzhou Medical University, Yantai (China)

    2015-05-08

    Abnormal high mobility group protein B1 (HMGB1) activation is involved in the pathogenesis of pulmonary fibrosis. Pulmonary rehabilitation mixture (PRM), which combines extracts from eight traditional Chinese medicines, has very good lung protection in clinical use. However, it is not known if PRM has anti-fibrotic activity. In this study, we investigated the effects of PRM on transforming growth factor-β1 (TGF-β1)-mediated and bleomycin (BLM)-induced pulmonary fibrosis in vitro and in vivo. The effects of PRM on TGF-β1-mediated epithelial-mesenchymal transition (EMT) in A549 cells, on the proliferation of human lung fibroblasts (HLF-1) in vitro, and on BLM-induced pulmonary fibrosis in vivo were investigated. PRM treatment resulted in a reduction of EMT in A549 cells that was associated with attenuating an increase of vimentin and a decrease of E-cadherin. PRM inhibited the proliferation of HLF-1 at an IC{sub 50} of 0.51 µg/mL. PRM ameliorated BLM-induced pulmonary fibrosis in rats, with reduction of histopathological scores and collagen deposition, and a decrease in α-smooth muscle actin (α-SMA) and HMGB1 expression. An increase in receptor for advanced glycation end-product (RAGE) expression was found in BLM-instilled lungs. PRM significantly decreased EMT and prevented pulmonary fibrosis through decreasing HMGB1 and regulating RAGE in vitro and in vivo. PRM inhibited TGF-β1-induced EMT via decreased HMGB1 and vimentin and increased RAGE and E-cadherin levels. In summary, PRM prevented experimental pulmonary fibrosis by modulating the HMGB1/RAGE pathway.

  14. Neupogen and mesenchymal stem cells are the novel therapeutic agents in regeneration of induced endometrial fibrosis in experimental rats.

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    Sabry, Dina; Mostafa, Abeer; Marzouk, Samar; Ibrahim, Walaa; Ali, Hanan H M; Hassan, Aymen; Shamaa, Ashraf

    2017-10-31

    Endometrial fibrosis is the presence of intrauterine adhesions (IUAs) after any uterine surgery or curettage and it results in infertility and recurrent pregnancy loss. We evaluated the role of human mesenchymal stem cells (hMSCs) as a therapeutic agent of endometrial fibrosis. We also compared the effect of MSCs with the effect of estrogen and neupogen either each alone or as a combined therapy with MSCs. This experimental study was performed on 84 albino rats which were divided into seven groups ( n =12 rats/group) as follows, group 1: normal control rats, group 2: induced fibrosis, group 3: induced fibrosis that received oral estrogen, group 4: induced fibrosis that received hMSCs, group 5: induced fibrosis that received hMSCs and estrogen, group 6: induced fibrosis that received neupogen, and group 7: induced fibrosis that received hMSCs and neupogen. The extent of fibrosis, vascularization, and inflammation were evaluated by; qRT-PCR for interleukin 1 (IL-1), interleukin 6 (IL-6), TNF, vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and RUNX; ELISA for connective tissue growth factor (CTGF); Western blotting for collagen-I; immunohistochemistry examination for VEGF and RUNX-2; and histopathological assessment. In therapeutic groups either by hMSCs alone or combined with estrogen or neupogen; fibrosis and inflammation (IL-1, IL-6, TNF, TGF-β, RUNX, CTGF, and collagen-I) were significantly decreased but vascularization (VEGF) was significantly increased ( P <0.05) compared with induced fibrosis group. The most significant result was obtained in fibrosis that received combined therapy of hMSCs and neupogen ( P =0.000). Stem cells and neupogen are a highly effective alternative regenerative agents in endometrial fibrosis. © 2017 The Author(s).

  15. Oxidized low-density-lipoprotein accumulation is associated with liver fibrosis in experimental cholestasis

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    Güldeniz Karadeniz

    2008-01-01

    Full Text Available OBJECTIVE: The aim of the present study was to examine the probable relationship between the accumulation of oxLDL and hepatic fibrogenesis in cholestatic rats. INTRODUCTION: There is growing evidence to support the current theories on how oxidative stress that results in lipid peroxidation is involved in the pathogenesis of cholestatic liver injury and fibrogenesis. One of the major and early lipid peroxidation products, OxLDL, is thought to play complex roles in various immuno-inflammatory mechanisms. METHODS: A prolonged (21-day experimental bile duct ligation was performed on Wistar-albino rats. Biochemical analysis of blood, histopathologic evaluation of liver, measurement of the concentration of malondialdehyde (MDA and superoxide-dismutase (SOD in liver tissue homogenates, and immunofluorescent staining for oxLDL in liver tissue was conducted in bile-duct ligated (n = 8 and sham-operated rats (n = 8. RESULTS: Significantly higher levels of MDA and lower concentrations of SOD were detected in jaundiced rats than in the sham-operated rats. Positive oxLDL staining was also observed in liver tissue sections of jaundiced rats. Histopathological examination demonstrated that neither fibrosis nor other indications of hepatocellular injury were found in the sham-operated group, while features of severe hepatocellular injury, particularly fibrosis, were found in jaundiced rats. CONCLUSION: Our results support the finding that either oxLDLs are produced as an intermediate agent during exacerbated oxidative stress or they otherwise contribute to the various pathomechanisms underlying the process of liver fibrosis. Whatever the mechanism, it is clear that an association exists between elevated oxLDL levels and hepatocellular injury, particularly with fibrosis. Further studies are needed to evaluate the potential effects of oxLDLs on the progression of secondary biliary cirrhosis.

  16. Relationship between fibrosis and lactate dehydrogenase isoenzymes in the experimental hypertrophic heart of rabbits

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    Revis, N.W.; Cameron, A.J.V.

    1978-06-01

    Cardiac hypertrophy was induced in rabbits by injecting either thyroxine or isoprenaline or by surgically constricting the abdominal aorta. An increase in heart weight was associated with a change in the lactate dehydrogenase isoenzyme pattern and an increase in fibrosis (as measured by hydroxyproline concentrations). Isoprenaline treatment led to a moderate increase in heart weight, a marked decrease in the heart/skeletal muscle subunit ratio of lactate dehydrogenase, and a marked increase in hydroxyproline. Thyroxine treatment led to a small increase in both heart weight and hydroxyproline and a small decrease in the heart/skeletal muscle subunit ratio. Coarctation of the aorta, in contrast, caused a marked increase in heart weight, a moderate decrease in heart/skeletal muscle subunit ratio, and a moderate increase in hydroxyproline. These results suggest that the decrease in the heart/skeletal muscle subunit ratio of lactate dehydrogenase in the experimental hypertrophic heart reflects the extent of myocardial fibrosis, rather than changes within the hypertrophied myocardial cells.

  17. The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis.

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    Kurowska-Stolarska, Mariola; Hasoo, Manhl K; Welsh, David J; Stewart, Lynn; McIntyre, Donna; Morton, Brian E; Johnstone, Steven; Miller, Ashley M; Asquith, Darren L; Millar, Neal L; Millar, Ann B; Feghali-Bostwick, Carol A; Hirani, Nikhil; Crick, Peter J; Wang, Yuqin; Griffiths, William J; McInnes, Iain B; McSharry, Charles

    2017-06-01

    Idiopathic pulmonary fibrosis (IPF) is progressive and rapidly fatal. Improved understanding of pathogenesis is required to prosper novel therapeutics. Epigenetic changes contribute to IPF; therefore, microRNAs may reveal novel pathogenic pathways. We sought to determine the regulatory role of microRNA (miR)-155 in the profibrotic function of murine lung macrophages and fibroblasts, IPF lung fibroblasts, and its contribution to experimental pulmonary fibrosis. Bleomycin-induced lung fibrosis in wild-type and miR-155 -/- mice was analyzed by histology, collagen, and profibrotic gene expression. Mechanisms were identified by in silico and molecular approaches and validated in mouse lung fibroblasts and macrophages, and in IPF lung fibroblasts, using loss-and-gain of function assays, and in vivo using specific inhibitors. miR-155 -/- mice developed exacerbated lung fibrosis, increased collagen deposition, collagen 1 and 3 mRNA expression, TGF-β production, and activation of alternatively activated macrophages, contributed by deregulation of the miR-155 target gene the liver X receptor (LXR)α in lung fibroblasts and macrophages. Inhibition of LXRα in experimental lung fibrosis and in IPF lung fibroblasts reduced the exacerbated fibrotic response. Similarly, enforced expression of miR-155 reduced the profibrotic phenotype of IPF and miR-155 -/- fibroblasts. We describe herein a molecular pathway comprising miR-155 and its epigenetic LXRα target that when deregulated enables pathogenic pulmonary fibrosis. Manipulation of the miR-155/LXR pathway may have therapeutic potential for IPF. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  18. Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease

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    Mackness Michael

    2009-01-01

    Full Text Available Abstract Background Paraoxonase-1 (PON1 is an antioxidant enzyme synthesized by the liver. It protects against liver impairment and attenuates the production of the pro-inflammatory monocyte chemoattractant protein-1 (MCP-1. We investigated the relationships between hepatic PON1 and MCP-1 expression in rats with liver disease and explored the possible molecular mechanisms involved. Methods CCl4 was administered for up to 12 weeks to induce liver damage. Serum and hepatic levels of PON1 and MCP-1, their gene and protein expression, nuclear transcription factors, and histological and biochemical markers of liver impairment were measured. Results High levels of PON1 and MCP-1 expression were observed at 12th week in the hepatocytes surrounding the fibrous septa and inflammatory areas. CCl4-administered rats had an increased hepatic PON1 concentration that was related to decreased gene transcription and inhibited protein degradation. Decreased PON1 gene transcription was associated with PPARδ expression. These changes were accompanied by increased hepatic MCP-1 concentration and gene expression. There were significant direct relationships between hepatic PON1 and MCP-1 concentrations (P = 0.005 and between PON1 and the amount of activated stellate cells (P = 0.001. Conclusion Our results from this experimental model suggest a hepato-protective role for PON1 against inflammation, fibrosis and liver disease mediated by MCP-1.

  19. B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis.

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    François, Antoine; Gombault, Aurélie; Villeret, Bérengère; Alsaleh, Ghada; Fanny, Manoussa; Gasse, Paméla; Adam, Sylvain Marchand; Crestani, Bruno; Sibilia, Jean; Schneider, Pascal; Bahram, Seiamak; Quesniaux, Valérie; Ryffel, Bernhard; Wachsmann, Dominique; Gottenberg, Jacques-Eric; Couillin, Isabelle

    2015-01-01

    Idiopathic pulmonary fibrosis (IPF) is a progressive devastating, yet untreatable fibrotic disease of unknown origin. We investigated the contribution of the B-cell activating factor (BAFF), a TNF family member recently implicated in the regulation of pathogenic IL-17-producing cells in autoimmune diseases. The contribution of BAFF was assessed in a murine model of lung fibrosis induced by airway administered bleomycin. We show that murine BAFF levels were strongly increased in the bronchoalveolar space and lungs after bleomycin exposure. We identified Gr1(+) neutrophils as an important source of BAFF upon BLM-induced lung inflammation and fibrosis. Genetic ablation of BAFF or BAFF neutralization by a soluble receptor significantly attenuated pulmonary fibrosis and IL-1β levels. We further demonstrate that bleomycin-induced BAFF expression and lung fibrosis were IL-1β and IL-17A dependent. BAFF was required for rIL-17A-induced lung fibrosis and augmented IL-17A production by CD3(+) T cells from murine fibrotic lungs ex vivo. Finally we report elevated levels of BAFF in bronchoalveolar lavages from IPF patients. Our data therefore support a role for BAFF in the establishment of pulmonary fibrosis and a crosstalk between IL-1β, BAFF and IL-17A. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis

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    Moser, Claus; van Gennip, Maria; Bjarnsholt, Thomas

    2009-01-01

    Moser C, van Gennip M, Bjarnsholt T, Jensen PO, Lee B, Hougen HP, Calum H, Ciofu O, Givskov M, Molin S, Hoiby N. Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host-pathogen interactions in cystic fibrosis. APMIS 2009; 117: 95-107. The dominant cause of premature...... death in patients suffering from cystic fibrosis (CF) is chronic lung infection with Pseudomonas aeruginosa. The chronic lung infection often lasts for decades with just one clone. However, as a result of inflammation, antibiotic treatment and different niches in the lungs, the clone undergoes...... and 2003) of the chronic lung infection of one CF patient using the seaweed alginate embedment model. The results showed that the non-mucoid clones reduced their virulence over time, resulting in faster clearing of the bacteria from the lungs, improved pathology and reduced pulmonary production...

  1. The effect of oophorectomy on epidural fibrosis after laminectomy: an experimental study in rats.

    Science.gov (United States)

    Çirci, Esra; Özalay, Metin; Caylak, Berrin; Bacanli, Didem; Derincek, Alihan; Tuncay, I Cengiz

    2013-01-01

    The aim of this study was to examine the effect of oophorectomy in the formation of epidural fibrosis in a rat laminectomy model. Thirty-six 12-month-old adult female Sprague-Dawley rats were used in this study. Rats were evenly divided into two groups; oophorectomized and sham-operated. Bilateral oophorectomy was performed on the 18 rats in the oophorectomized group. Three weeks after oophorectomy, rats in both groups underwent complete bilateral laminectomy at the L2 and L3 vertebral levels. Rats were divided into 3 equal groups and sacrificed in groups of 4 at the 4th, 8t, and 12th weeks postoperatively and the lumbar spine excised en bloc, fixed and decalcified. Sections were stained with hematoxylin and eosin and Masson's trichrome were used to evaluate epidural fibrosis, acute inflammation, chronic inflammation, and vascular proliferation. The mean histological sum grade of the epidural fibrosis was greater in the oophorectomized group (p>0.05). Endogenous estrogen could have an effect on epidural fibrosis formation after lumbar laminectomy in rats.

  2. Pan-PPAR agonist IVA337 is effective in experimental lung fibrosis and pulmonary hypertension.

    Science.gov (United States)

    Avouac, Jerome; Konstantinova, Irena; Guignabert, Christophe; Pezet, Sonia; Sadoine, Jeremy; Guilbert, Thomas; Cauvet, Anne; Tu, Ly; Luccarini, Jean-Michel; Junien, Jean-Louis; Broqua, Pierre; Allanore, Yannick

    2017-11-01

    To evaluate the antifibrotic effects of the pan-peroxisome proliferator-activated receptor (PPAR) agonist IVA337 in preclinical mouse models of pulmonary fibrosis and related pulmonary hypertension (PH). IVA337 has been evaluated in the mouse model of bleomycin-induced pulmonary fibrosis and in Fra-2 transgenic mice, this latter being characterised by non-specific interstitial pneumonia and severe vascular remodelling of pulmonary arteries leading to PH. Mice received two doses of IVA337 (30 mg/kg or 100 mg/kg) or vehicle administered by daily oral gavage up to 4 weeks. IVA337 demonstrated at a dose of 100 mg/kg a marked protection from the development of lung fibrosis in both mouse models compared with mice receiving 30 mg/kg of IVA337 or vehicle. Histological score was markedly reduced by 61% in the bleomycin model and by 50% in Fra-2 transgenic mice, and total lung hydroxyproline concentrations decreased by 28% and 48%, respectively, as compared with vehicle-treated mice. IVA337 at 100 mg/kg also significantly decreased levels of fibrogenic markers in lesional lungs of both mouse models. In addition, IVA337 substantially alleviated PH in Fra-2 transgenic mice by improving haemodynamic measurements and vascular remodelling. In primary human lung fibroblasts, IVA337 inhibited in a dose-dependent manner fibroblast to myofibroblasts transition induced by TGF-β and fibroblast proliferation mediated by PDGF. We demonstrate that treatment with 100 mg/kg IVA337 prevents lung fibrosis in two complementary animal models and substantially attenuates PH in the Fra-2 mouse model. These findings confirm that the pan-PPAR agonist IVA337 is an appealing therapeutic candidate for these cardiopulmonary involvements. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  3. Effects of Topical Cova™, Tisseel® and Adcon® Gel Application on the Development of Spinal Peridural Fibrosis: An Experimental Study in Rats.

    Science.gov (United States)

    Kazanci, Atilla; Gurcan, Oktay; Gurcay, Ahmet Gurhan; Onder, Evrim; Kazanci, Burak; Yaman, Mesut Emre; Bavbek, Murad

    2017-01-01

    Leptomeningeal adhesions and fibrosis in the spinal peridural space are the most common causes of post-laminectomy syndrome. Fibrin sealant agents and membrane barriers are commonly used for hemostasis and sealing purposes in spinal surgery. Peridural fibrosis may be a risk of the usage of these topical agents. In this study, we aimed to compare the effects of Cova ™, Tisseel® and Adcon ® Gel on the development of spinal peridural fibrosis in the experimental rat model. Thirty-two Sprague Dawley female rats were randomly divided into 4 groups. Groups were constituted as group 1; Cova™ group (laminectomy+Cova™), group 2; Tisseel® group (laminectomy+Tisseel®), group 3; Adcon®Gel group (laminectomy + Adcon®Gel), group 4; control group (laminectomy only). Six weeks after laminectomy, spinal columns were removed en bloc between L1 and L4 vertebrae. Peridural fibrosis was evaluated histologically and the results were compared statistically. Statistically significant reduction of peridural fibrosis was achieved in groups 1, 2, and 3 when compared with the control group (p 0.05). Fibrin sealant agent Tisseel® and membrane barrier Cova™ do not enhance peridural fibrosis following laminectomy. Cova™ and Tisseel® may be appropriate for hemostasis and leakage prevention during the spinal surgery and it is safe to leave these materials on the operation surface.

  4. Dried Human Amniotic Membrane Does Not Alleviate Inflammation and Fibrosis in Experimental Strabismus Surgery

    Directory of Open Access Journals (Sweden)

    Bo Young Chun

    2013-01-01

    Full Text Available Purpose. The purpose of this study was to evaluate the efficacy of dried human amniotic membrane (AM in reducing the postoperative inflammatory response and scarring after strabismus surgery. Methods. The inflammatory response at the extraocular muscle reattachment site was analyzed after superior rectus (SR resection in 12 rabbits. Dried human AM (Ambiodry2 was applied between the resected SR muscle plane and Tenon’s capsule of the left eyes of rabbits. As a control, the right eyes of rabbits underwent SR resection only. The surgeon randomly ordered which eye gets operated first during the experiment. Two weeks later, enucleation was performed. Six sagittal sections were made for each eye at the insertion of the SR muscle. The grade of postoperative inflammation and the presence of fibrosis were evaluated in histological examinations. Results. There was no statistically significant difference in the intensity of inflammation and fibrous proliferation between the eyes treated with dried human AM after SR resection and those treated with SR resection only. Conclusions. The use of dried human AM was not effective in controlling the postoperative inflammation and scarring in rabbit eyes after extraocular muscle surgery. However, this may be due to the devitalized dry preparation of human AM (Ambiodry2, which may have lost the expected anti-inflammatory and anti-scarring properties, and further studies on humans may be necessary.

  5. Effects of rapamycin on reduction of peridural fibrosis: an experimental study.

    Science.gov (United States)

    Luo, Like; Zhang, Chifei; Zhao, Jinmin; Wei, Qingjun; Li, Xiaofeng

    2015-02-13

    Peridural fibrosis (PF) is a normal complication after lumbar surgery. It is a challenge for both surgeons and patients. Rapamycin (RPM), a novel antibiotic with anti-proliferative and immunosuppressive properties, has been shown to be effective in preventing uncontrolled scar proliferation diseases. The object of the present research was to investigate the effects of RPM on inhibiting PF in vitro and in vivo. In vitro, the fibroblasts collected and isolated from the rat tail skin were cultured with/without RPM and cell counting was performed. In vivo, the double-blinded study was conducted in 60 healthy Wistar rats divided randomly into 3 groups: 1) RPM treatment group; 2) Vehicle treatment group; 3) Control group. Rats underwent a L1-L2 level laminectomy with a satisfactory anesthetization. Four weeks post-operatively, the Rydell score, histological analysis, hydroxyproline content, vimentin expressional level, and inflammatory cytokines expressional levels were assessed. In vitro, RPM showed ability to prevent fibroblast proliferation. In vivo, the laminectomy was well tolerated by all rats, which were killed 4 weeks post-operatively. The Rydell score, histological evaluation, hydroxyproline content, vimentin expression level, and inflammatory activity showed the positive effect of RPM in preventing peridural adhesion, inhibiting fibrotic formation and collagen synthesis, and down-regulating inflammation. In the present primary study, RPM showed good efficacy in preventing the proliferation of fibroblasts. RPM can prevent rat peridural adhesion through inhibiting collagen synthesis, fibroblasts proliferation, and inflammatory activity.

  6. Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: an experimental study

    International Nuclear Information System (INIS)

    Lefaix, Jean-Louis; Delanian, Sylvie; Leplat, Jean-Jacques; Tricaud, Yves; Martin, Michele; Nimrod, Abraham; Baillet, Francois; Daburon, Francois

    1996-01-01

    Purpose: To establish how far liposomal copper/zinc superoxide dismutase (Cu/Zn-SOD) and manganese superoxide dismutase (Mn-SOD), respectively, reduce radiation-induced fibrosis (RIF), using a well-characterized pig model of RIF permitting the design of a controlled laboratory experiment. Methods and Materials: In this model of acute localized gamma irradiation simulating accidental overexposure in humans, three groups of five large white pigs were irradiated using a collimated 192 Ir source to deliver a single dose of 160 Gy onto the skin surface (100%) of the outer side of the thigh. A well-defined block of subcutaneous fibrosis involving skin and skeletal muscle developed 6 months after irradiation. One experimental group of five pigs was then injected i.m. with 10 mg/10 kg b.wt. of Cu/Zn-SOD, twice a week for 3 weeks, and another experimental group of five was injected with 10 mg/10 kg b.wt. of Mn-SOD, three times a week for 3 weeks. Five irradiated control pigs were injected with physiological serum. Animals were assessed for changes in the density of the palpated fibrotic block and in the dimensions of the projected cutaneous surface. Block depth was determined by ultrasound. Physical and sonographic findings were confirmed by autopsy 12-14 weeks after completing SOD injections. The density, length, width, and depth of the fibrotic block, and the areas and volume of its projected cutaneous surface were compared before treatment, 1, 3, and 6 weeks thereafter, and at autopsy, 12-14 weeks after treatment ended. Results: The experimental animals exhibited no change in behaviour and no abnormal clinical or anatomic signs. Whether they were given Cu/Zn- or Mn-SOD, significant and roughly equivalent softening and shrinking of the fibrotic block were noted in all treated animals between the first week after treatment ended and autopsy, when mean regression was 45% for length and width, 30% for depth, and 70% for area and volume. Histologic examination showed

  7. Modeling pulmonary fibrosis by abnormal expression of telomerase/apoptosis/collagen V in experimental usual interstitial pneumonia

    Energy Technology Data Exchange (ETDEWEB)

    Parra, E.R.; Pincelli, M.S. [Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Teodoro, W.R.; Velosa, A.P.P. [Disciplina de Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Martins, V.; Rangel, M.P.; Barbas-Filho, J.V.; Capelozzi, V.L. [Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil)

    2014-06-04

    Limitations on tissue proliferation capacity determined by telomerase/apoptosis balance have been implicated in pathogenesis of idiopathic pulmonary fibrosis. In addition, collagen V shows promise as an inductor of apoptosis. We evaluated the quantitative relationship between the telomerase/apoptosis index, collagen V synthesis, and epithelial/fibroblast replication in mice exposed to butylated hydroxytoluene (BHT) at high oxygen concentration. Two groups of mice were analyzed: 20 mice received BHT, and 10 control mice received corn oil. Telomerase expression, apoptosis, collagen I, III, and V fibers, and hydroxyproline were evaluated by immunohistochemistry, in situ detection of apoptosis, electron microscopy, immunofluorescence, and histomorphometry. Electron microscopy confirmed the presence of increased alveolar epithelial cells type 1 (AEC1) in apoptosis. Immunostaining showed increased nuclear expression of telomerase in AEC type 2 (AEC2) between normal and chronic scarring areas of usual interstitial pneumonia (UIP). Control lungs and normal areas from UIP lungs showed weak green birefringence of type I and III collagens in the alveolar wall and type V collagen in the basement membrane of alveolar capillaries. The increase in collagen V was greater than collagens I and III in scarring areas of UIP. A significant direct association was found between collagen V and AEC2 apoptosis. We concluded that telomerase, collagen V fiber density, and apoptosis evaluation in experimental UIP offers the potential to control reepithelization of alveolar septa and fibroblast proliferation. Strategies aimed at preventing high rates of collagen V synthesis, or local responses to high rates of cell apoptosis, may have a significant impact in pulmonary fibrosis.

  8. S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis

    Directory of Open Access Journals (Sweden)

    Mazo DF

    2013-06-01

    Full Text Available Daniel FC Mazo,1 Marcelo G de Oliveira,2 Isabel VA Pereira,1 Bruno Cogliati,3 José T Stefano,1 Gabriela FP de Souza,2 Fabíola Rabelo,1 Fabiana R Lima,4 Venâncio A Ferreira Alves,4 Flair J Carrilho,1 Claudia PMS de Oliveira1 1University of São Paulo School of Medicine, Department of Gastroenterology, Clinical Division, Hepatology Branch (LIM-07, Sao Paulo, Brazil; 2Institute of Chemistry, University of Campinas, Campinas, Sao Paulo, Brazil; 3University of Sao Paulo School of Veterinary Medicine and Animal Science, Department of Pathology, Sao Paulo, Brazil; 4University of São Paulo School of Medicine, Department of Pathology (LIM14, São Paulo, Brazil Abstract: S-Nitroso-N-acetylcysteine (SNAC is a water soluble primary S-nitrosothiol capable of transferring and releasing nitric oxide and inducing several biochemical activities, including modulation of hepatic stellate cell activation. In this study, we evaluated the antifibrotic activity of SNAC in an animal model of nonalcoholic steatohepatitis (NASH induced in Sprague-Dawley rats fed with a choline-deficient, high trans fat diet and exposed to diethylnitrosamine for 8 weeks. The rats were divided into three groups: SNAC, which received oral SNAC solution daily; NASH, which received the vehicle; and control, which received standard diet and vehicle. Genes related to fibrosis (matrix metalloproteinases [MMP]-13, -9, and -2, transforming growth factor ß-1 [TGFß-1], collagen-1a, and tissue inhibitors of metalloproteinase [TIMP-1 and -2] and oxidative stress (heat-shock proteins [HSP]-60 and -90 were evaluated. SNAC led to a 34.4% reduction in the collagen occupied area associated with upregulation of MMP-13 and -9 and downregulation of HSP-60, TIMP-2, TGFß-1, and collagen-1α. These results indicate that oral SNAC administration may represent a potential antifibrotic treatment for NASH. Keywords: nitric oxide, S-nitroso-N-acetylcysteine, fibrogenesis, NASH, diethylnitrosamine

  9. Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid

    Directory of Open Access Journals (Sweden)

    Li Chun-jun

    2012-06-01

    Full Text Available Abstract Background Alpha-lipoic acid (ALA, a naturally occurring compound, exerts powerful protective effects in various cardiovascular disease models. However, its role in protecting against diabetic cardiomyopathy (DCM has not been elucidated. In this study, we have investigated the effects of ALA on cardiac dysfunction, mitochondrial oxidative stress (MOS, extracellular matrix (ECM remodeling and interrelated signaling pathways in a diabetic rat model. Methods Diabetes was induced in rats by I.V. injection of streptozotocin (STZ at 45 mg/kg. The animals were randomly divided into 4 groups: normal groups with or without ALA treatment, and diabetes groups with or without ALA treatment. All studies were carried out 11 weeks after induction of diabetes. Cardiac catheterization was performed to evaluate cardiac function. Mitochondrial oxidative biochemical parameters were measured by spectophotometeric assays. Extracellular matrix content (total collagen, type I and III collagen was assessed by staining with Sirius Red. Gelatinolytic activity of Pro- and active matrix metalloproteinase-2 (MMP-2 levels were analyzed by a zymogram. Cardiac fibroblasts differentiation to myofibroblasts was evaluated by Western blot measuring smooth muscle actin (α-SMA and transforming growth factor–β (TGF-β. Key components of underlying signaling pathways including the phosphorylation of c-Jun N-terminal kinase (JNK, p38 MAPK and ERK were also assayed by Western blot. Results DCM was successfully induced by the injection of STZ as evidenced by abnormal heart mass and cardiac function, as well as the imbalance of ECM homeostasis. After administration of ALA, left ventricular dysfunction greatly improved; interstitial fibrosis also notably ameliorated indicated by decreased collagen deposition, ECM synthesis as well as enhanced ECM degradation. To further assess the underlying mechanism of improved DCM by ALA, redox status and cardiac remodeling associated

  10. A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats.

    Science.gov (United States)

    Wang, Ning; Feng, Yibin; Cheung, Fan; Chow, Oi-Yee; Wang, Xuanbin; Su, Weiwei; Tong, Yao

    2012-11-29

    Bear bile and Coptidis Rhizoma have been used in Chinese medicine with a long tradition in treating heat-diseases. Both bear bile and Coptidis Rhizoma are used to treat liver diseases in clinical practice of Chinese Medicine. Since bears are currently endangered, it raises the question whether the use of bear bile is ethical. To look for substitute for bear bile, the aim of this study is to compare the anti-fibrotic effects of Coptidis Rhizoma and its major component berberine with the actions of bear bile and its major compound tauroursodeoxycholic acid on experimental liver fibrosis in rats. Quality assessment was conducted with high performance liquid chromatography. The experimental liver fibrosis in rats was induced by carbon tetrachloride, alcohol, and bile duct ligation respectively. The biochemical criteria in the blood and tissue samples were measured to evaluate the anti-fibrotic properties and underlying mechanisms of the drugs. Coptidis Rhizoma Aqueous Extract (CRAE), berberine, and bear bile exerted anti-fibrotic properties on various liver fibrosis models in rats. CRAE and berberine significantly reduced the peroxidative stress in liver through increasing the superoxide dismutase enzyme activity. CRAE and berberine were able to excrete bilirubin products from the liver and protect hepatocytes from cholestatic damage. The effect of CRAE and berberine are comparable to that of bear bile. Instead of using bear bile, CRAE and berberine can be potential substitutes in treating liver fibrosis.

  11. Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis.

    Science.gov (United States)

    Pacheco, Rodrigo Goulart; Esposito, Christiano Costa; Müller, Lucas C M; Castelo-Branco, Morgana T L; Quintella, Leonardo Pereira; Chagas, Vera Lucia A; de Souza, Heitor Siffert P; Schanaider, Alberto

    2012-08-28

    To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis. Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine, butyrate, or saline. Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure. Follow-up colonoscopy was performed every 4 wk for 12 wk. The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β, tumor necrosis factor-alpha, and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay. Colonoscopies of the diverted segment showed mucosa with hyperemia, increased number of vessels, bleeding and mucus discharge. Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic (P < 0.02) and histological scores (P < 0.01) and restored the densities of collagen fibers in tissue (P = 0.015; P = 0.001), the number of goblet cells (P = 0.021; P = 0.029), and the rate of apoptosis within the epithelium (P = 0.043; P = 0.011) to normal values. The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine. The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis.

  12. A new model of experimental fibrosis in hindlimb skeletal muscle of adult mdx mouse mimicking muscular dystrophy.

    Science.gov (United States)

    Desguerre, Isabelle; Arnold, Ludovic; Vignaud, Alban; Cuvellier, Sylvain; Yacoub-Youssef, Houda; Gherardi, Romain K; Chelly, Jamel; Chretien, Fabrice; Mounier, Rémi; Ferry, Arnaud; Chazaud, Bénédicte

    2012-06-01

    Duchenne Muscular Dystrophy (DMD) is characterized by the lack of dystrophin that leads to severe myofiber degeneration. We have shown that endomysial fibrosis is correlated with age at ambulation loss in DMD patients. However, the dystrophin-deficient mdx mouse does not have fibrotic lesions in adult limb muscles. Here, we describe a model of chronic mechanical muscle injury that triggers chronic lesions in mdx hindlimb muscle. Micromechanical injuries were performed daily in tibialis anterior muscles for 2 weeks. Endomysial fibrosis appeared beginning 1 week post-injury, remained stable for 3 months and was associated with loss of specific maximal force. Fibrosis was associated with an increased expression of factors involved in fibrogenesis including α-smooth muscle actin, connective tissue growth factor, and lysyl oxidase, which colocalized with collagen deposits. This induced fibrotic dystrophic model may be useful to study mechanisms of fibrosis in dystrophinopathies and to evaluate antifibrotic treatments. Copyright © 2012 Wiley Periodicals, Inc.

  13. Pulmonary Fibrosis

    Science.gov (United States)

    Pulmonary fibrosis is a condition in which the tissue deep in your lungs becomes scarred over time. This tissue gets thick ... blood may not get enough oxygen. Causes of pulmonary fibrosis include environmental pollutants, some medicines, some connective ...

  14. Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways

    Science.gov (United States)

    Hernández-Aquino, Erika; Zarco, Natanael; Casas-Grajales, Sael; Ramos-Tovar, Erika; Flores-Beltrán, Rosa E; Arauz, Jonathan; Shibayama, Mineko; Favari, Liliana; Tsutsumi, Víctor; Segovia, José; Muriel, Pablo

    2017-01-01

    AIM To study the molecular mechanisms involved in the hepatoprotective effects of naringenin (NAR) on carbon tetrachloride (CCl4)-induced liver fibrosis. METHODS Thirty-two male Wistar rats (120-150 g) were randomly divided into four groups: (1) a control group (n = 8) that received 0.7% carboxy methyl-cellulose (NAR vehicle) 1 mL/daily p.o.; (2) a CCl4 group (n = 8) that received 400 mg of CCl4/kg body weight i.p. 3 times a week for 8 wk; (3) a CCl4 + NAR (n = 8) group that received 400 mg of CCl4/kg body weight i.p. 3 times a week for 8 wk and 100 mg of NAR/kg body weight daily for 8 wk p.o.; and (4) an NAR group (n = 8) that received 100 mg of NAR/kg body weight daily for 8 wk p.o. After the experimental period, animals were sacrificed under ketamine and xylazine anesthesia. Liver damage markers such as alanine aminotransferase (ALT), alkaline phosphatase (AP), γ-glutamyl transpeptidase (γ-GTP), reduced glutathione (GSH), glycogen content, lipid peroxidation (LPO) and collagen content were measured. The enzymatic activity of glutathione peroxidase (GPx) was assessed. Liver histopathology was performed utilizing Masson’s trichrome and hematoxylin-eosin stains. Zymography assays for MMP-9 and MMP-2 were carried out. Hepatic TGF-β, α-SMA, CTGF, Col-I, MMP-13, NF-κB, IL-1, IL-10, Smad7, Smad3, pSmad3 and pJNK proteins were detected via western blot. RESULTS NAR administration prevented increases in ALT, AP, γ-GTP, and GPx enzymatic activity; depletion of GSH and glycogen; and increases in LPO and collagen produced by chronic CCl4 intoxication (P < 0.05). Liver histopathology showed a decrease in collagen deposition when rats received NAR in addition to CCl4. Although zymography assays showed that CCl4 produced an increase in MMP-9 and MMP-2 gelatinase activity; interestingly, NAR administration was associated with normal MMP-9 and MMP-2 activity (P < 0.05). The anti-inflammatory, antinecrotic and antifibrotic effects of NAR may be attributed to its ability

  15. El trabajo del menor

    OpenAIRE

    Herrera Espinosa, Ana María

    2013-01-01

    El trabajo infantil o trabajo de menores es definido por UNICEF como “el trabajo excesivo realizado por niños con consecuencias negativas para su adecuado desarrollo físico, mental o emocional y, que además, les priva de una educación que merecen”. Aproximadamente 300 millones de niños en todo el mundo son obligados a trabajar en jornadas laborales excesivas y más de 170 millones lo hacen en condiciones insalubres. Las causas que explican el trabajo infantil incluyen: situaciones d...

  16. Introduction to Pulmonary Fibrosis

    Science.gov (United States)

    ... Events Become An Advocate Volunteer Ways To Give Pulmonary Fibrosis www.lung.org > Lung Health and Diseases > ... Pulmonary Fibrosis > Introduction Share this page: Introduction to Pulmonary Fibrosis What Is Pulmonary Fibrosis? Pulmonary fibrosis is ...

  17. Learn About Pulmonary Fibrosis

    Science.gov (United States)

    ... Events Become An Advocate Volunteer Ways To Give Pulmonary Fibrosis www.lung.org > Lung Health and Diseases > Lung ... Pulmonary Fibrosis > Introduction Share this page: Introduction to Pulmonary Fibrosis What Is Pulmonary Fibrosis? Pulmonary fibrosis is a ...

  18. Cystic Fibrosis

    Science.gov (United States)

    ... fixing the CFTR protein. Learn more Living with Cystic Fibrosis A diagnosis of CF is life changing for a family. However, in the last 2 to 3 decades, significant strides have been made so that children born ... Doctor about Cystic Fibrosis Making notes before your visit, as well as ...

  19. Diccionario de Trabajo Social

    Directory of Open Access Journals (Sweden)

    Octavio Vásquez Aguado

    2014-03-01

    Full Text Available La realización de un diccionario de Trabajo Social, como el que reseñamos aquí, constituye un esfuerzo intelectual de primera magnitud en el que un número importante de académicos y profesionales vinculados a la disciplina participan con el objetivo de contribuir, decididamente, a la consolidación de una terminología en torno a los conceptos claves, las teorías, los modelos, los referentes históricos fundamentales, que han configurado y definen al Trabajo Social como profesión y disciplina.

  20. FELICIDAD EN EL TRABAJO

    OpenAIRE

    Salvatore Moccia

    2016-01-01

    Uno de los principales objetivos de la psicología del trabajo y de las organizaciones es promover tanto el bienestar como el rendimiento de los empleados. Sin embargo, los distintos autores nos son unánimes respectos a los fundamentos de la felicidad. El objetivo de este trabajo es presentar las enormes contribuciones de la Psicología Positiva y de la Filosofía al tema de la felicidad y sus influencias en el ámbito organizativo y de la productividad, ofreciendo una revisión de los distintos a...

  1. El trabajo en equipo

    OpenAIRE

    Brugarolas, A. (A.)

    1992-01-01

    Este es el último punto del manuscrito, que inesperadamente ha cobrado vida y se ha trasladado a la introducción, y es que el trabajo en equipo se ha convertido en un trabajo que busca equipo. Por este motivo, tras denunciar al autor, solicita encontrar un equipo que lo corrija, incremente, modifique e ilumine. Inmediatamente he pensado en posibles candidatos, que propondré al primero que acepte formar equipo, para dar cumplida satisfacción a un texto que ha salido reivindicativo y fiel a sí ...

  2. Mechanisms of liver fibrosis associated with experimental Fasciola hepatica infection: roles of Fas2 proteinase and hepatic stellate cell activation.

    Science.gov (United States)

    Marcos, Luis A; Terashima, Angélica; Yi, Pedro; Andrade, Roy; Cubero, Francisco J; Albanis, Efsevia; Gotuzzo, Eduardo; Espinoza, Jose R; Friedman, Scott L

    2011-02-01

    We have evaluated the possible mechanisms of liver fibrosis caused by Fasciola hepatica in an animal model and in culture using immortalized human stellate cells. Liver biopsies of F. hepatica-infected rats were performed at wk 8 and 16. Serum-starved LX-2 cells, a human stellate cell line, were exposed to increasing concentrations of Fas2 antigen. The expression of key fibrosis-related genes was evaluated by qRT-PCR. There was a significant correlation between fibrogenic gene expression and both intensity and duration of infection. LX-2 cells exposed to Fas2 showed progressively increased expression of mRNAs for Collagen I, alpha-smooth muscle-actin, platelet-derived growth factor beta receptor, and tissue inhibitor of metalloproteinase II; inhibition of Fas2 cysteine proteinase activity by E-64 abrogated these increases, suggesting that the protease activity of Fas2 is involved in fibrogenic stimulation. In summary, F. hepatica infection is associated with up-regulation of mRNAs associated with hepatic fibrogenesis in vivo and in activated hepatic stellate cells.

  3. ¿Es necesaria la reconstrucción de la conjuntiva?: Trabajo experimental en conejos albinos para evaluar la neogénesis de la conjuntiva

    Directory of Open Access Journals (Sweden)

    E. A. Moretti

    Full Text Available En los defectos de espesor total del párpado inferior de gran magnitud, siempre ha sido regla de oro la reconstrucción de la lamela posterior (tarso y conjuntiva palpebral. Esto es debido a que el tono del músculo orbicularis oculi no alcanza a mantener el soporte necesario para resistir la acción de la gravedad y/o contractura cicatricial. Además la ausencia de conjuntiva provocaría lesiones sobre la córnea ocular. Es por ello que el empleo de injertos compuestos condromucosos ha sido insustituible. El presente trabajo de investigación fue realizado en 20 conejos albinos con el objeto de evaluar la posibilidad de emplear cartílago auricular para la reconstrucción del tarso sin colocación de mucosa a modo de conjuntiva sobre dicho cartílago. Los resultados obtenidos permiten confirmar por diferentes tinciones histológicas sobre biopsias comparadas con zonas testigo, el crecimiento de tejido conjuntival sobre el pericondrio sin provocar lesiones oculares (neogénesis de conjuntiva. Los hallazgos encontrados provocan importantes y sustanciales cambios en la cirugía reconstructiva del párpado inferior debido a que de esta manera, no sería necesaria la reconstrucción de la conjuntiva palpebral, siendo útil exclusivamente la colocación de cartílago.

  4. Trabajo Social en internet

    Directory of Open Access Journals (Sweden)

    ANONIMO

    2004-01-01

    Full Text Available Este artículo introduce algunos caminos para acceder a información sobre trabajo social en internet, específicamente en relación con las asociaciones y gremios a nivel nacional, regional e internacional. El artículo está dividido en tres partes. La primer

  5. Learning about Cystic Fibrosis

    Science.gov (United States)

    ... What do we know about heredity and cystic fibrosis? Cystic fibrosis (CF) is the most common, fatal genetic ... FAQ Top of page Additional Resources for Cystic Fibrosis Information Cystic Fibrosis [ghr.nlm.nih.gov] Summary FAQ from ...

  6. The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection

    Directory of Open Access Journals (Sweden)

    Natalia Smoktunowicz

    2015-09-01

    Full Text Available TGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression of fibrosis in a two-hit mouse model of murine γ-herpesvirus 68 (MHV-68 infection on the background of pre-existing bleomycin-induced pulmonary fibrosis. Assessment of total lung collagen levels in combination with ex vivo micro-computed tomography (µCT analysis of whole lungs demonstrated that MHV-68 infection did not enhance lung collagen deposition in this two-hit model but led to a persistent and exacerbated inflammatory response. Moreover, µCT reconstruction and analysis of the two-hit model revealed distinguishing features of diffuse ground-glass opacities and consolidation superimposed on pre-existing fibrosis that were reminiscent of those observed in acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF. Virally-infected murine fibrotic lungs further displayed evidence of extensive inflammatory cell infiltration and increased levels of CCL2, TNFα, IL-1β and IL-10. Blockade of TGFβ-ALK5 signalling attenuated lung collagen accumulation in bleomycin-alone injured mice, but this anti-fibrotic effect was reduced in the presence of concomitant viral infection. In contrast, inhibition of TGFβ-ALK5 signalling in virally-infected fibrotic lungs was associated with reduced inflammatory cell aggregates and increased levels of the antiviral cytokine IFNγ. These data reveal newly identified intricacies for the TGFβ-ALK5 signalling axis in experimental lung fibrosis, with different outcomes in response to ALK5 inhibition depending on the presence of viral infection. These findings raise important considerations for the targeting of TGFβ signalling responses in the context of pulmonary fibrosis.

  7. Comparison of the therapeutic effectiveness of human CD34+ and rat bone marrow mesenchymal stem cells on improvement of experimental liver fibrosis in Wistar rats.

    Science.gov (United States)

    Sayyed, Hayam G; Osama, Amany; Idriss, Naglaa K; Sabry, Dina; Abdelrhim, Azza S; Bakry, Rania

    2016-01-01

    Human umbilical cord blood (UCB) cells and bone marrow mesenchymal stem cells (BM-MSCs) have numerous advantages as grafts for cell transplantation. We hypothesized differing impacts of human UCB cells and rat BM-MSCs on reversal of hepatic injury and revival of liver function in carbon tetrachloride (CCl 4 )-induced liver fibrosis. Forty rats were divided into 4 groups; control group, CCl 4 group, CCl 4 /CD34 + group and CCl 4 /BM-MSCs group. Blood samples were driven from rats at 4, 8 and 12 weeks to measure serum concentration of albumin and alanine aminotransferase (ALT). Quantitative expression of collagen Iα, TGF-β, α-SMA, albumin, MMP-2, MMP-9 and TNF-α were assessed by polymerase chain reaction. Histopathological examination of the liver tissue was performed. GFP labeled cells were detected in groups injected with stem cells. Regarding liver function, CD34 + were more efficient than BM-MSCs in elevating albumin ( P <0.05) and reducing ALT ( P <0.05) concentrations. Concerning gene expression, CD34 + were more effective than BM-MSCs in reducing gene expressions of collagen Iα ( P <0.01), TGF-β1 ( P <0.01) and α-SMA ( P <0.01). Both CD34 + and BM-MSCs have the same efficacy in reducing TNF-α ( P <0.001 and P <0.01, respectively). Furthermore, CD34 + were more valuable than BM-MSCs in increasing gene expression of albumin ( P <0.05) and MMP-9 ( P <0.01). Taken together; human UCB CD34 + stem cells were more efficient in improvement of experimental liver injury than BM-MSCs. This study highlighted an important role of human UCB CD34 + stem cells in liver fibrosis therapy.

  8. emergencia del trabajo liberado

    Directory of Open Access Journals (Sweden)

    Rocío Gómez Z.

    2008-01-01

    Full Text Available Este ensayo sugiere que habría una inestimable conexión entre el compromiso subjetivo y emocional de los jóvenes usuarios de Internet, que invierten tiempo y deseo en realizar un conjunto variado de obras menores (correos electrónicos, imágenes de sí mismos en Facebook, trozos de música, mantenimiento de la bitácora en la Red, y los malestares del bienestar urbano. Estas obras menores encarnan y objetivan las demandas de trabajo liberado -frecuentemente reprimidas, pospuestas, administradas o reguladas-, que algunos de los nuevos repertorios tecnológicos canalizan y movilizan vigorosamente.

  9. FELICIDAD EN EL TRABAJO

    Directory of Open Access Journals (Sweden)

    Salvatore Moccia

    2016-05-01

    Full Text Available Uno de los principales objetivos de la psicología del trabajo y de las organizaciones es promover tanto el bienestar como el rendimiento de los empleados. Sin embargo, los distintos autores nos son unánimes respectos a los fundamentos de la felicidad. El objetivo de este trabajo es presentar las enormes contribuciones de la Psicología Positiva y de la Filosofía al tema de la felicidad y sus influencias en el ámbito organizativo y de la productividad, ofreciendo una revisión de los distintos autores, subrayando las diferencias entre ellos y, sobre todo, abogando por un consenso en el campo de los fundamentos de la felicidad. De hecho, la gran diferencia entre los distintos autores es la falta de unanimidad respecto a los fundamentos de la felicidad. Mientras algunos autores optan por un concepto de felicidad que se identifica con el de placer, otros prefieren una mezcla de placer, compromiso y significado, evitando, sin embargo, definir la felicidad o, más bien, ocultándola detrás de la palabra bienestar. Sin embargo, si se lograra un consenso sobre las distintas aportaciones al tema de la felicidad, éste representaría un concepto mucho más manejable desde la perspectiva psicológica.

  10. Endomyocardial fibrosis.

    Science.gov (United States)

    Tarun, K; Naresh, K; Khullar, R K; Daga, M K

    2009-03-01

    We present a case report of a 26-year-old male from Bulandsahar, India. The patient presented with right heart failure. Evaluation revealed peripheral eosinophilia. An echocardiogram and MRI showed biventricular hypertrophy with obliteration of the ventricular apices, typical of endomyocardial fibrosis. This condition is rare in Bulandsahar, India.

  11. The pathogenesis of cardiac fibrosis.

    Science.gov (United States)

    Kong, Ping; Christia, Panagiota; Frangogiannis, Nikolaos G

    2014-02-01

    Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. This review discusses the cellular effectors and molecular pathways implicated in the pathogenesis of cardiac fibrosis. Although activated myofibroblasts are the main effector cells in the fibrotic heart, monocytes/macrophages, lymphocytes, mast cells, vascular cells and cardiomyocytes may also contribute to the fibrotic response by secreting key fibrogenic mediators. Inflammatory cytokines and chemokines, reactive oxygen species, mast cell-derived proteases, endothelin-1, the renin/angiotensin/aldosterone system, matricellular proteins, and growth factors (such as TGF-β and PDGF) are some of the best-studied mediators implicated in cardiac fibrosis. Both experimental and clinical evidence suggests that cardiac fibrotic alterations may be reversible. Understanding the mechanisms responsible for initiation, progression, and resolution of cardiac fibrosis is crucial to design anti-fibrotic treatment strategies for patients with heart disease.

  12. [Retroperitoneal fibrosis].

    Science.gov (United States)

    Babski, Paweł; Wojtuń, Stanisław; Gil, Jerzy

    2007-05-01

    Retroperitoneal fibrosis is a rare clinical entity characterised by the presence of patologic collagen tissue in a retroperitoneal space. The fibrous mass covers abdominal organs causing their disfunctions. RPF was described at the begining of XX century but its etiology is not clear yet. Usually it causes an ureter obstuction and hydronephrosis, that is why most commonly is diagnosed by urologists and nephrologists. However, retroperitoneal fibrosis can be multifacial disease. In some patients localisation of fibrosis is atypical and manifestationns can be varied. Gastrological symptoms like jaundice, bowel obstuction, ascites can occure. Besides, some early signs of RPF are nonspecific and can imitate alarming symptoms of neoplasma, e.g.: weight loss, anemia, malaise, anorexia, fever. This force us to initiate gastrological investigation. The awareness of this disease is important. The early diagnosis and treatment improves prognosis and alows to avoid heavy complications. In typical cases radiology is often enough for diagnosis. However, histological examination is needed in many cases, especialy when patological mass is located atypical. A treatment is made up of farmacology and surgery. The first one is based on steroids, immunossuppressant and tamoxifen. Surgery is needed to eliminate organs obstruction.

  13. About Cystic Fibrosis

    Science.gov (United States)

    ... Research Share Back to top What Is Cystic Fibrosis? Cystic fibrosis is a progressive, genetic disease that causes ... carrier. Read more about diagnosis. According to the Cystic Fibrosis Foundation Patient Registry, in the United States: More ...

  14. Therapies for Cystic Fibrosis

    Science.gov (United States)

    ... Search What Is CF? X close ABOUT CYSTIC FIBROSIS Learn about cystic fibrosis, a genetic disorder that affects the lungs, pancreas, ... or your child has just been diagnosed with cystic fibrosis, or your doctor has recommended testing for CF, ...

  15. Cystic Fibrosis and Pregnancy

    Science.gov (United States)

    ... Complications & Loss > Pregnancy complications > Cystic fibrosis and pregnancy Cystic fibrosis and pregnancy E-mail to a friend Please ... this page It's been added to your dashboard . Cystic fibrosis (CF) is a condition that affects breathing and ...

  16. Trabajo, crisis global y salud

    OpenAIRE

    2010-01-01

    Esta publicación presenta los principales resultados del 7º. Seminario Internacional Trabajo, Crisis Global y Salud coordinado por el Doctorado Interfacultades en Salud Publica, cuyo debate se centró en las condiciones del trabajo en un mundo globalizado, las consecuencias de la crisis global sobre las condiciones de trabajo y su impacto en la salud de las personas. Se contó con la presencia de líderes regionales en salud del trabajo y seguridad de países como Argentina, Uruguay, Perú, México...

  17. Construcción de un modelo animal de fibrosis pulmonar inducido por Bleomicina

    Directory of Open Access Journals (Sweden)

    Dacia Malambo García

    2016-01-01

    Full Text Available La fibrosis pulmonar es una enfermedad crónica, progresiva y letal, cuya etiología se desconoce. El modelo de fibrosis pulmonar inducida por Bleomicina en ratas es útil para ilustrar la patobiología in vivo de la enfermedad, así como para identificar nuevos blancos farmacológicos y estimar la eficiencia de nuevas moléculas o procedimientos Objetivo: El objetivo de este trabajo fue construir un modelo animal de fibrosis pulmonar secundaria a Bleomicina, en ratas Wistar, como herramienta que pueda servir de base para futuros diseños experimentales. Materiales y métodos: Se trabajó con dos grupos de ratas Wistar para la administración del medicamento por vía intratraqueal. El grupo experimental recibió una dosis única (2.0 U/Kg de Bleomicina, mientras que el grupo control recibió un volumen equivalente de solución salina. A los 14 o 28 días se realizó un lavado broncoalveolar con recuento total y diferencial celular y análisis histopatológico pulmonar. Resultados: La histología de una parte del grupo experimental tratado con Bleomicina y sacrificado a los 14 días reveló daño pulmonar caracterizado por inflamación aguda, hemorragia intraalveolar y proliferación fibroblástica intersticial incipiente; en el resto del grupo experimental la histología a 28 días reveló además alteración de la arquitectura pulmonar debida a fibrosis y aumento en el número de macrófagos intraalveolares e inflamación linfocitaria. Conclusiones: Se implementó satisfactoriamente un modelo de fibrosis pulmonar inducido farmacológicamente por Bleomicina en ratas Wistar.

  18. Neurophysiological and histopathological evaluation of low-dose radiation on the cauda equina and postlaminotomy fibrosis: an experimental study in the rat.

    Science.gov (United States)

    Su, Wei-Ren; Lee, Jung-Shun; Chen, Helen Hai-Wen; Wang, Liang-Chao; Huang, Yi-Hung; Jung, Yun-Chih; Jou, I-Ming

    2009-03-01

    We evaluated the electrophysiological changes to the cauda equina after low-dose external irradiation in a postlaminotomy fibrosis model in rats. To clarify the immediate and long-term electrophysiological responses of antifibrotic radiation therapy in a fibrosis model. Low-dose perioperative radiation therapy inhibits scar formation. However, its efficacy for preventing fibrosis-induced compressive neuropathy and its potential adverse effect on underlying neural structures have not been studied. Twenty-four rats were placed in 3 groups of 8: group I, sham operation (laminar exposure alone) with a single fraction of 700 cGy external irradiation given using a 9-MeV electron beam 24 hours postsurgery; group II, left L5 hemilaminectomy (laminotomy) alone; and group III, left L5 hemilaminectomy with the same radiation protocol as group 1. We recorded mixed-nerve-elicited somatosensory-evoked potentials (M-SSEP)- and dermal (D)-SSEP at the thoracolumbar junction, and L1-L2 interspinous ligament after percutaneously stimulating the posterior tibial nerve at the bilateral medial ankle and L5 dermatomal fields. We compared the potentials recorded immediately before, 30 minutes, 2 weeks, and 1, 2, and 3 months after surgery on the operated and nonoperated sides. We used gross dissection and histologic sections to evaluate the degree of perineural fibrosis and walking-track analysis for neurologic evaluation. Pre- and postoperative (30 minutes and 2 weeks) M- and D-SSEP were not statistically different. In group II, the relative amplitude of D-SSEP (elicited from 5 dermatomes) 1, 2, and 3 months postsurgery was lower; however, the M-SSEP in all groups and D-SSEP of groups I and III remained constant. Histologic evaluation of radiation efficacy showed that the frequency and extent of peridural fibrosis was consistently lower in group II than in group III. Low-dose irradiation reduced peridural fibrosis and prevented fibrosis-induced radiculopathy. The radiation caused no

  19. Different regulation of miR-29a-3p in glomeruli and tubules in an experimental model of angiotensin II-dependent hypertension: potential role in renal fibrosis.

    Science.gov (United States)

    Castoldi, Giovanna; di Gioia, Cira; Giollo, Fabrizio; Carletti, Raffaella; Bombardi, Camila; Antoniotti, Marco; Roma, Francesca; Zerbini, Gianpaolo; Stella, Andrea

    2016-03-01

    The aim of this study was to evaluate the role of the angiotensin II (Ang II) induced-differential miRNA expression in renal glomerular and tubulo-interstitial fibrosis in an experimental model of Ang II-dependent hypertension. To clarify this issue, Sprague Dawley rats were treated with Ang II (200 ng/kg per minute, n = 15) or physiological saline (n = 14) for 4 weeks. Systolic blood pressure and albuminuria were measured every 2 weeks. At the end of the experimental period, renal glomerular and tubulo-interstitial fibrosis was evaluated by histomorphometric analysis, after Sirius-Red and Masson's trichrome staining. Ang II increased systolic blood pressure (P renal tubules and up-regulated in glomeruli. Real-time polymerase chain reaction (PCR) experiments confirmed in Ang II-treated rats a down-regulation of miR-29a-3p in tubules (P renal tubules is different from the one exerted in the glomeruli and that miR-29a-3p targets MMP-2. These results suggest that the development of renal fibrosis at glomerular and tubulo-interstitial level depends on different molecular mechanisms. © 2016 John Wiley & Sons Australia, Ltd.

  20. TRABAJO SEXUAL MASCULINO. YO PUTO. REPENSANDO EL TRABAJO SEXUAL MASCULINO.

    OpenAIRE

    Rodríguez, Luis Manuel Hernández

    2015-01-01

    La finalidad de este trabajo es mostrar a partir de una investigación etnográfica realizada con jóvenes los significados del trabajo sexual masculino, entendiendo esta práctica desde la perspectiva feminista como un sistema complejo de actitudes y toma de decisiones. En este sentido, a partir de esta investigación trataremos de arrojar luz sobre una realidad que aparece frecuentemente invisibilizada, estigmatizada y que difiere del trabajo sexual femenino. Nuestro acercamiento lo hemos realiz...

  1. Biomarkers for liver fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Jacobs, Jon M.; Burnum-Johnson, Kristin E.; Baker, Erin M.; Smith, Richard D.; Gritsenko, Marina A.; Orton, Daniel

    2017-05-16

    Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.

  2. Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive.

    Directory of Open Access Journals (Sweden)

    Antoine eHuart

    2015-02-01

    Full Text Available Background: Renal tubulointerstitial fibrosis is the pathological hallmark of chronic kidney disease. Currently, inhibitors of the renin angiotensin system (RAS remain the sole therapy in human displaying antifibrotic properties. Further antifibrotic molecules are needed. We have recently reported that the delayed blockade of the bradykinin B1 receptor (B1R reduced the development of fibrosis in two animal models of renal fibrosis. The usefulness of new drugs also resides in outperforming the gold standards and eventually being additive or complementary to existing therapies. Methods: In this study we compared the efficacy of a B1R antagonist (B1Ra with that of an angiotensin type 1 receptor antagonist (AT1a in the unilateral ureteral obstruction (UUO model of renal fibrosis and determined whether bi-therapy presented higher efficacy than any of the drugs alone. Results: B1R antagonism was as efficient as the gold-standard AT1a treatment. However bitherapy did not improve the antifibrotic effects at the protein level. We sought for the reason of the absence of this additive effect by studying the expression of a panel of genes involved in the fibrotic process. Interestingly, at the molecular level the different drugs targeted different players of fibrosis that, however, in this severe model did not result in improved reduction of fibrosis at the protein level. Conclusions: As the B1R is induced specifically in the diseased organ and thus potentially displays low side effects it might be an interesting alternative in cases of poor tolerability to RAS inhibitors.

  3. Loss of Twist1 in the Mesenchymal Compartment Promotes Increased Fibrosis in Experimental Lung Injury by Enhanced Expression of CXCL12

    Science.gov (United States)

    Tan, Jiangning; Tedrow, John R.; Nouraie, Mehdi; Dutta, Justin A.; Miller, David T.; Li, Xiaoyun; Yu, Shibing; Chu, Yanxia; Juan-Guardela, Brenda; Kaminski, Naftali; Ramani, Kritika; Biswas, Partha S.; Zhang, Yingze

    2017-01-01

    Idiopathic pulmonary fibrosis (IPF) is a disease characterized by the accumulation of apoptosis-resistant fibroblasts in the lung. We have previously shown that high expression of the transcription factor Twist1 may explain this prosurvival phenotype in vitro. However, this observation has never been tested in vivo. We found that loss of Twist1 in COL1A2+ cells led to increased fibrosis characterized by very significant accumulation of T cells and bone marrow–derived matrix-producing cells. We found that Twist1-null cells expressed high levels of the T cell chemoattractant CXCL12. In vitro, we found that the loss of Twist1 in IPF lung fibroblasts increased expression of CXCL12 downstream of increased expression of the noncanonical NF-κB transcription factor RelB. Finally, blockade of CXCL12 with AMD3100 attenuated the exaggerated fibrosis observed in Twist1-null mice. Transcriptomic analysis of 134 IPF patients revealed that low expression of Twist1 was characterized by enrichment of T cell pathways. In conclusion, loss of Twist1 in collagen-producing cells led to increased bleomycin-induced pulmonary fibrosis, which is mediated by increased expression of CXCL12. Twist1 expression is associated with dysregulation of T cells in IPF patients. Twist1 may shape the IPF phenotype and regulate inflammation in fibrotic lung injury. PMID:28179498

  4. Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2

    Directory of Open Access Journals (Sweden)

    Ritu S. Sharma

    2018-01-01

    Conclusions: Pharmacologic activation of Nrf2 in mice that had already been rendered obese and insulin resistant reversed insulin resistance, suppressed hepatic steatosis, and mitigated against NASH and liver fibrosis, effects that we principally attribute to inhibition of ER, inflammatory, and oxidative stress.

  5. Genetics Home Reference: cystic fibrosis

    Science.gov (United States)

    ... Share: Email Facebook Twitter Home Health Conditions Cystic fibrosis Cystic fibrosis Printable PDF Open All Close All Enable Javascript ... lung damage, including the formation of scar tissue (fibrosis) and cysts in the lungs. Most people with cystic fibrosis ...

  6. Cystic fibrosis - nutrition

    Science.gov (United States)

    Cystic fibrosis (CF) is a life-threatening disease that causes thick, sticky mucus to build up in the ... Egan ME, Green DM, Voynow JA. Cystic fibrosis. In: Kliegman RM, ... of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap ...

  7. Cystic fibrosis: case report

    International Nuclear Information System (INIS)

    Park, Si Hyun; Lee, Hyun Ju; Kim, Ji Hye; Park, Chol Heui

    2002-01-01

    Cystic fibrosis is an autosomal recessive genetic disease. Among Caucasians, it is the most common cause of pulmonary insufficiency during the first three decades of life. The prevalence of cystic fibrosis varies according to ethnic origin: it is common among Caucasians but rare among Asians. We report a case in which cystic fibrosis with bronchiectasis and hyperaeration was revealed by high-resolution CT, and mutation of the cystic fibrosis conductance transmembrane regulator gene (CFTR) by DNA analysis

  8. Cystic fibrosis: case report

    International Nuclear Information System (INIS)

    Park, Si Hyun; Lee, Hyun Ju; Kim, Ji Hye; Park, Chol Heui

    2002-01-01

    Cystic fibrosis is a autosomal recessive genetic disease. Among caucasians, it is the most common cause of pulmonary insufficiency during the first three decades of life. The prevalence of cystic fibrosis varies according to ethnic origin: it is common among caucasians but rare among Asians. We report a case in which cystic fibrosis with bronchiectasis and hyperaeration was revealed by high-resolution CT, and mutation of the cystic fibrosis conductance transmembrane regulator gene (CFTR) by DNA analysis

  9. Cystic Fibrosis (CF): Chloride Sweat Test

    Science.gov (United States)

    ... on this topic for: Parents Kids Teens Cystic Fibrosis Cystic Fibrosis and Nutrition Cystic Fibrosis (CF) Respiratory Screen: Sputum Cystic Fibrosis: Diet and Nutrition Cystic Fibrosis Cystic Fibrosis: Diet and Nutrition View more Partner Message ...

  10. Informes y documentos de Trabajo

    DEFF Research Database (Denmark)

    Humlebæk, Carsten

    análisis sustantivo en cada uno de los diferentes paquetes de trabajo. Se ha tratado de que sea un documento lo suficiente amplio como para que tengan cabida una variada gama de explicaciones sobre la articulación del nacionalismo español en la izquierda. Por lo tanto, no hemos descartado hipótesis de...

  11. Idiomas, diversidad y trabajo social

    DEFF Research Database (Denmark)

    Jensen, Niels Rosendal

    2010-01-01

    Anmeldelsen af tidsskriftet Revista de Trabajo Social tager udgangspunkt i, at socialpædagoger og socialarbejdere tilsyneladende kun er optaget af begrebet sprog i et beskedent omfang, selv om sproget fylder så ufatteligt meget i deres hverdagsliv (faglig kommunikation osv.). Udgivelsesdato: Marts...

  12. Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.

    Directory of Open Access Journals (Sweden)

    Belén Picatoste

    Full Text Available BACKGROUND: Myocardial fibrosis is a key process in diabetic cardiomyopathy. However, their underlying mechanisms have not been elucidated, leading to a lack of therapy. The glucagon-like peptide-1 (GLP-1 enhancer, sitagliptin, reduces hyperglycemia but may also trigger direct effects on the heart. METHODS: Goto-Kakizaki (GK rats developed type-II diabetes and received sitagliptin, an anti-hyperglycemic drug (metformin or vehicle (n=10, each. After cardiac structure and function assessment, plasma and left ventricles were isolated for biochemical studies. Cultured cardiomyocytes and fibroblasts were used for in vitro assays. RESULTS: Untreated GK rats exhibited hyperglycemia, hyperlipidemia, plasma GLP-1 decrease, and cardiac cell-death, hypertrophy, fibrosis and prolonged deceleration time. Moreover, cardiac pro-apoptotic/necrotic, hypertrophic and fibrotic factors were up-regulated. Importantly, both sitagliptin and metformin lessened all these parameters. In cultured cardiomyocytes and cardiac fibroblasts, high-concentration of palmitate or glucose induced cell-death, hypertrophy and fibrosis. Interestingly, GLP-1 and its insulinotropic-inactive metabolite, GLP-1(9-36, alleviated these responses. In addition, despite a specific GLP-1 receptor was only detected in cardiomyocytes, GLP-1 isoforms attenuated the pro-fibrotic expression in cardiomyocytes and fibroblasts. In addition, GLP-1 receptor signalling may be linked to PPARδ activation, and metformin may also exhibit anti-apoptotic/necrotic and anti-fibrotic direct effects in cardiac cells. CONCLUSIONS: Sitagliptin, via GLP-1 stabilization, promoted cardioprotection in type-II diabetic hearts primarily by limiting hyperglycemia e hyperlipidemia. However, GLP-1 and GLP-1(9-36 promoted survival and anti-hypertrophic/fibrotic effects on cultured cardiac cells, suggesting cell-autonomous cardioprotective actions.

  13. Trabajo contingente y productividad en los servicios

    OpenAIRE

    Rimbau-Gilabert, Eva; Myrthianos, Vasileios

    2012-01-01

    Trabajo contingente, flexibilidad laboral exter na, productividad del trabajo, servicios, servicios intensivos en conocimiento Este estudio analiza el efecto del trabajo contingente sobre la productividad del trabajo en el sector servicios. Para ello, se analizan los datos de una muestra de 645 empresas de servicios localizadas en Cataluña, mediante una regresión lineal múltiple jerárquica. Los resultados muestran que el empleo de formas de trabajo no permanentes, como...

  14. Informes y documentos de Trabajo

    DEFF Research Database (Denmark)

    Humlebæk, Carsten

    El propósito de este artículo es reflexionar y proponer hipótesis explicativas a las dificultades de la izquierda para articular un discurso nacionalista español. El trabajo se enmarca dentro del proyecto “Nacionalismo español: discursos y praxis desde la izquierda (1982-2008)” financiado por el...... análisis sustantivo en cada uno de los diferentes paquetes de trabajo. Se ha tratado de que sea un documento lo suficiente amplio como para que tengan cabida una variada gama de explicaciones sobre la articulación del nacionalismo español en la izquierda. Por lo tanto, no hemos descartado hipótesis de...

  15. Trabajo infantil e inasistencia escolar

    Directory of Open Access Journals (Sweden)

    Antonio Sandoval Ávila

    2007-01-01

    Full Text Available Trabajo infantil e inasistencia escolar El capitalismo neoliberal ha generalizado la pobreza que obliga a muchas familias a recurrir al trabajo de los hijos para poder subsistir. Por el trabajo, los menores desertan de la escuela. Cuando adultos, por la pérdida en educación, sólo podrán acceder a las ocupaciones de menor calificación y peor pagadas. Por ello, tienen muchas probabilidades de ser los futuros padres de nuevos niños trabajadores reproduciendo intergeneracionalmente la pobreza. La educación es el primer paso para romper el círculo de la pobreza; hay relación entre los niveles de educación y las remuneraciones que las ersonas pueden alcanzar. El desarrollo descansa en el acelerado cambio tecnológico que no es más que el conocimiento científico aplicado a la producción. Crear conocimiento supone educación superior, y en la base de ésta está la educación básica, que es el cimiento de cualquier modelo de desarrollo que aspire a la equidad. No educar a los menores significa desperdiciar la formación de capital humano, ello traba el desarrollo nacional. Sin educación no habrá capital humano calificado como motor básico de la productividad y la competitividad.

  16. El Derecho universal del Trabajo

    Directory of Open Access Journals (Sweden)

    Héctor-Hugo Barbagelata

    2014-01-01

    Full Text Available La idea de un derecho universal del trabajo no es nueva, en realidad es más antigua quela legislación del trabajo y por lo tanto, más antigua que la propia rama del derecho que estudia estas cuestiones.Sí, son nuevos los avances que con ese objetivo se han ido registrando desde fines del siglo pasado.I- Introducción.- II Antecedentes.- II Constitucionalización e internacionalización.- IV Principios y criterios de interpretación del bloque de constitucionalidad.- A Criterio fundado en las condiciones del Estado Social de Derecho; B Principio de complementariedad e interdependencia de todas las normas sobre derechos humanos; C Primacía de la disposición más favorable a la persona humana; D Criterio resultante del principio de progresividad.; E Principio de irreversibilidad o de no regresión. F Principio de autoejecución y autoaplicación..- V Conflictos entre los derechos fundamentales .- VI.- Los principios filosóficos: a La Justicia social ; b La especificidad del trabajo humano; c Reafirmación de la dignidad de la persona humana; VII Conclusiones. 

  17. Socializacio?n y trabajo

    OpenAIRE

    Herrera Montero, Luis

    2014-01-01

    En este capi?tulo se caracteriza, describe y explica la experiencia de socializacio?n de nin?os, nin?as y adolescentes del CMT con relacio?n a la tema?tica de trabajo y a su vivencia con el “mundo del trabajo”. En este cometido, se han disen?ado y aplicado entrevistas y variantes procedimentales tales como conversaciones tematizadas que permitan obtener datos e informaciones co-producidos con diversos actores del proyecto: NNA, autoridades, docentes y padres-madres de familia. De inicio se...

  18. Trabajo infantil: una realidad avasallante

    OpenAIRE

    Abud Rodríguez, Silvina Vanesa

    2015-01-01

    p. 87-89 El trabajo infantil es una realidad que se ha venido gestando a lo largo de la historia, en especial desde la revolución industrial. Existe en todos los países del mundo, sin importar sus niveles de desarrollo, sus modelos económicos o las ideologías de sus gobernantes. Es de vital importancia conocer cuáles son los desafíos que asume el Estado como principal proveedor de respuestas a las necesidades de los niños y niñas que se encuentran en situación de vulnerabilidad. La present...

  19. Neonatal cystic fibrosis screening test

    Science.gov (United States)

    Cystic fibrosis screening - neonatal; Immunoreactive trypsinogen; IRT test; CF - screening ... Cystic fibrosis is a disease passed down through families. CF causes thick, sticky mucus to build up in ...

  20. Diagnosis of cystic fibrosis

    NARCIS (Netherlands)

    H.J. Veeze

    1995-01-01

    textabstractApplying the sweat-test as the first choice of test when a diagnosis of cystic fibrosis is suspected is still common practice and advisable. Since the cloning of the CFTR gene more than 400 different cystic fibrosis (CF) mutations have already been identified. The use of CF mutation

  1. Imaging pulmonary fibrosis

    International Nuclear Information System (INIS)

    Brauner, M.W.; Rety, F.; Naccache, J.M.; Girard, F.; Valeyre, D.F.

    2001-01-01

    Localized fibrosis of the lung is usually scar tissue while diffuse pulmonary fibrosis is more often a sign of active disease. Chronic infiltrative lung disease may be classified into four categories: idiopathic pneumonitis, collagen diseases, granulomatosis (sarcoidosis), and caused by known diseases (pneumoconiosis, hypersensitivity pneumonitis, drug-induced lung disease, radiation). (authors)

  2. Morphological aspects of the myocarditis and myositis in Calomys callosus experimentally infected with Trypanosoma cruzi: fibrogenesis and spontaneous regression of fibrosis

    Directory of Open Access Journals (Sweden)

    Sonia G. Andrade

    1994-09-01

    Full Text Available Calomys callosus a wild rodent, is a natural host of Trypanosoma cruzi. Twelve C. callosus were infected with 10(5 trypomastigotes of the F strain (a myotropic strain of T. cruzi. Parasitemia decreased on the 21 st day becoming negative around the 40th day of infection. All animals survived but had positive parasitological tests, until the end of the experiment. The infected animals developed severe inflammation in the myocardium and skeletal muscle. This process was pronounced from the 26 th to the 30th day and gradually subsided from the 50 th day becoming absent or residual on the 64 th day after infection. Collagen was identified by the picro Sirius red method. Fibrogenesis developed early, but regression of fibrosis occurred between the 50th and 64th day. Ultrastructural study disclosed a predominance of macrophages and fibroblasts in the inflammatory infiltrates, with small numbers of lymphocytes. Macrophages had active phagocytosis and showed points of contact with altered muscle cells. Different degrees of matrix expansion were present, with granular and fibrilar deposits and collagen bundles. These alterations subsided by the 64th days. Macrophages seem to be the main immune effector cell in the C. callosus model of infection with T. cruzi. The mechanisms involved in the rapid fibrogenesis and its regression deserve further investigation.

  3. Betulinic acid ameliorates experimental diabetic-induced renal inflammation and fibrosis via inhibiting the activation of NF-κB signaling pathway.

    Science.gov (United States)

    Wang, Shaogui; Yang, Zhiying; Xiong, Fengxiao; Chen, Cheng; Chao, Xiaojuan; Huang, Junying; Huang, Heqing

    2016-10-15

    Diabetic nephropathy (DN) is the leading cause of end-stage renal failure and is characterized by excessive deposition of extracellular matrix (ECM) proteins such as fibronectin (FN), in the glomerular mesangium and tubulointerstitium. Betulinic acid (BA), a pentacyclic triterpene derived from the bark of the white birch tree, has been demonstrated to have many pharmacological activities. However, the effect of BA on DN has not been fully elucidated. To explore the possible anti-inflammatory effects of BA and their underlying mechanisms, we used streptozotocin-induced diabetic rat kidneys and high glucose-treated glomerular mesangial cells. Our study showed BA could inhibit the degradation of IκBα and the activity of NF-κB in diabetic rat kidneys and high glucose-induced mesangial cells, resulting in reduction of FN expression. In addition, BA suppressed the DNA binding activity and transcriptional activity of NF-κB in high glucose-induced glomerular mesangial cells (GMCs). Furthermore, BA enhanced the interaction between IκBα and β-arrestin2 in mesangial cells. Taken together, our data suggest BA inhibits NF-κB activation through stabilizing NF-κB inhibitory protein IκBα, thereby preventing diabetic renal fibrosis. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  4. An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1.

    Science.gov (United States)

    Lv, Peizhen; Zhao, Jinmin; Su, Wei; Liang, Xiaonan; Zhang, Kun

    2015-07-01

    To investigate the effect of hyperbaric oxygen treatment (HBO) on prevention of epidural fibrosis in laminectomy rats. A controlled, double-blinded study was performed in sixty healthy adult Wistar rats, mean weight 250 g. L1-L2 levels laminectomy were performed. Randomly, all rats were divided into three groups, with 20 in each group: (1) short-term HBO treatment group; (2) long-term HBO treatment (LHBO) group; and (3) Sham group (laminectomy without treatment). Four weeks post-operation, all rats were killed. The Rydell classification, hydroxyproline content, vimentin cells density, capillary density, and inflammatory factors expression were evaluated. The histological evaluation showed less epidural scar adhesions in LHBO group than other two groups. The hydroxyproline content, Rydell score, vimentin cells density, capillary density, and inflammatory factors expression all suggested better results in LHBO group than other two groups. It was concluded that HBO treatment might be beneficial in inhibiting collagen deposition and inflammatory activity and prevent epidural scar adhesion in laminectomy rat and, therefore, shows potential for clinical use.

  5. An Experimental Novel Study: Angelica sinensis Prevents Epidural Fibrosis in Laminectomy Rats via Downregulation of Hydroxyproline, IL-6, and TGF-β1

    Directory of Open Access Journals (Sweden)

    Chao Zhang

    2013-01-01

    Full Text Available With laminectomy being widely accepted as the treatment for lumbar disorders, epidural fibrosis (EF is a common complication for both the patients and the surgeons alike. Currently, EF is thought to cause recurrent postoperative pain after laminectomy or after discectomy. Angelica sinensis is a traditional Chinese medicine which has shown anti-inflammatory, antifibrotic, and antiproliferative properties. The object of this study was to investigate the effects of Angelica sinensis on the prevention of post-laminectomy EF formation in a rat model. A controlled double-blinded study was conducted in sixty healthy adult Wistar rats that underwent laminectomy at the L1-L2 levels. They were divided randomly into 3 groups according to the treatment method, with 20 in each group: (1 Angelica sinensis treatment group, (2 saline treatment group, and (3 sham group (laminectomy without treatment. All rats were euthanized humanely 4 weeks after laminectomy. The hydroxyproline content, Rydell score, vimentin cells density, fibroblasts density, inflammatory cells density, and inflammatory factors expressions all suggested better results in Angelica sinensis group than the other two groups. Topical application of Angelica sinensis could inhibit fibroblasts proliferation and TGF-β1 and IL-6 expressions and prevent epidural scar adhesion in postlaminectomy rat model.

  6. An Experimental Novel Study: Angelica sinensis Prevents Epidural Fibrosis in Laminectomy Rats via Downregulation of Hydroxyproline, IL-6, and TGF- β 1.

    Science.gov (United States)

    Zhang, Chao; Kong, Xiaohong; Zhou, Hengxing; Liu, Chang; Zhao, Xuechao; Zhou, Xianhu; Su, Yanhua; Sharma, Hari S; Feng, Shiqing

    2013-01-01

    With laminectomy being widely accepted as the treatment for lumbar disorders, epidural fibrosis (EF) is a common complication for both the patients and the surgeons alike. Currently, EF is thought to cause recurrent postoperative pain after laminectomy or after discectomy. Angelica sinensis is a traditional Chinese medicine which has shown anti-inflammatory, antifibrotic, and antiproliferative properties. The object of this study was to investigate the effects of Angelica sinensis on the prevention of post-laminectomy EF formation in a rat model. A controlled double-blinded study was conducted in sixty healthy adult Wistar rats that underwent laminectomy at the L1-L2 levels. They were divided randomly into 3 groups according to the treatment method, with 20 in each group: (1) Angelica sinensis treatment group, (2) saline treatment group, and (3) sham group (laminectomy without treatment). All rats were euthanized humanely 4 weeks after laminectomy. The hydroxyproline content, Rydell score, vimentin cells density, fibroblasts density, inflammatory cells density, and inflammatory factors expressions all suggested better results in Angelica sinensis group than the other two groups. Topical application of Angelica sinensis could inhibit fibroblasts proliferation and TGF- β 1 and IL-6 expressions and prevent epidural scar adhesion in postlaminectomy rat model.

  7. Diseño experimental de un sumidero de CO2 y sus implicaciones en el cambio climático. Una experiencia de trabajo con alumnos en el laboratorio de Educación Secundaria

    Directory of Open Access Journals (Sweden)

    Raquel Boronat-Gil

    2018-01-01

    Full Text Available El desarrollo teórico del cambio climático en el aula de Educación Secundaria requiere de experiencias recreativas que demuestren –in situ– diferentes aspectos del proceso global. La presente comunicación muestra una actividad de laboratorio, y el consiguiente trabajo del alumnado, para comprobar la reducción de gases de efecto invernadero mediante la aplicación de una tecnología básica, de bajo costo y que puede realizarse con materiales disponibles en cualquier laboratorio escolar. La analogía didáctica llevada a cabo entre el CO2 producido por el metabolismo microbiano dentro de una botella cerrada y su reacción con una base fuerte generadora de una presión inferior a la atmosférica (como consecuencia de la reacción del dióxido de carbono con una base, visible con un sencillo manómetro en U, será objeto de debate entre profesor-alumno, analizándose y especulando su captura con la repercusión a nivel mundial de mejora en el calentamiento global.

  8. Fibrosis in tubularized skin flaps in rats, using silicon catheters with two different degrees of flexibility: experimental model Fibrose em retalhos tubulizados de pele de ratos usando cateteres de diferentes flexibilidades como molde: modelo experimental

    Directory of Open Access Journals (Sweden)

    Antonio Henrique Rodrigues dos Passos

    2008-06-01

    Full Text Available PURPOSE: Microscopically evaluate the intensity of fibrosis in tubularized skin flaps on the back of Wistar rats, using silicon molds with different degrees of flexibility. METHODS: Twenty rats were submitted to three tubularized skin flaps on their backs. In two tubular flaps, we placed, as a mold, silicon catheters with different degrees of flexibility and removed them on the seventh day after the surgery. They were divided into two groups and euthanized, on the seventh and twenty-first days respectively after the surgery for the collection of the pieces, coloration with Masson tricromic, quantification of the area of each sample and comparison among the groups. RESULTS: Fibrosis was less intense on the tubular flaps where a catheter was not used as a mold. No significant difference was verified among the pieces with the silicon catheters, but there was a tendency of less fibrosis on the tubules with the most flexible catheter. CONCLUSION: There was no significant difference among the two catheter types. Fibrosis was less intense in the flaps where the mold was not used.OBJETIVO: Avaliar microscopicamente a intensidade da fibrose em retalhos tubulares de pele do dorso de ratos Wistar em uso de moldes de silicone de diferentes flexibilidades. MÉTODOS: Vinte animais foram submetidos à confecção de três retalhos tubulizados de pele na região dorsal. Em dois túbulos foram colocados, como molde, cateteres de silicone com flexibilidades diferentes e retirados no sétimo dia após a cirurgia. Foram divididos em dois grupos e sacrificados, respectivamente, no sétimo e vigésimo primeiro dia após a cirurgia para a coleta das peças, coloração pelo tricrômico de Masson, quantificação da área de cada amostra e comparação entre os grupos. RESULTADOS: A fibrose foi menos intensa nos retalhos tubulares em que não se usou cateter como molde. Não se verificou diferença significativa entre os retalhos com os cateteres de silicone, mas sim

  9. Macrophage Responses to Epithelial Dysfunction Promote Lung Fibrosis in Aging

    Science.gov (United States)

    2017-10-01

    response to repeated injury over the lifespan explains the delayed onset of lung fibrosis until the later decades of life . We will use our experimental...explains the delayed onset of lung fibrosis until the later decades of life . We will use our experimental findings in mice to guide an unbiased...performed in house and not being outsourced. Actual or anticipated problems or delays and actions or plans to resolve them: Nothing to report. Changes

  10. Markers of hepatic fibrosis.

    Science.gov (United States)

    Caballería, Llorenç; Torán, Pere; Caballería, Joan

    2017-10-18

    Chronic liver diseases constitute a major health problem. Chronic liver inflammation, defined by the degree of hepatic fibrosis, is asymptomatic in a significant percentage of patients; hence, the disease often remains undiagnosed until it has reached very advanced phases and, frequently, when the damage is irreversible. Ideally, patients should be screened during the initial phases of chronic inflammation, thus allowing for the effective management of the natural evolution of the disease by stopping or delaying its course. Standard diagnostic methods (transaminase determination or abdominal ultrasonography) do not allow for the early diagnosis of the degree of fibrosis. A liver biopsy is the invasive method of choice to screen for fibrosis, however, due to its limitations, non-invasive diagnostic methods such as elastography or serological markers are increasingly used as a good alternative for the early diagnosis of the degree of fibrosis. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  11. Development and time-course of bleomycin-induced pulmonary fibrosis in NMRI mice

    Directory of Open Access Journals (Sweden)

    Jafarian-Dehkordi A.

    2007-04-01

    Full Text Available Bleomycin-induced pulmonary fibrosis is a widely used experimental model for human lung fibrosis. The severity of fibrosis varies among different strains of mice and investigation on different strains and finding the mechanisms of variation is important in understanding the pathogenesis of human lung fibrosis. In the present study, NMRI mice were used to investigate the severity and also time-course of bleomycin-induced pulmonary fibrosis in comparison with C57BL/6 mice. After single dose administration of intratracheal bleomycin, the fibrotic response was studied by biochemical measurement of collagen deposition and semiquantitative analysis of pathological lung changes. NMRI mice developed lung fibrosis from 1 to 4 week after bleomycin instillation, with significant increases in lung collagen content and significant morphological changes (P < 0.05. These findings indicate that NMRI mice might be suitable as an experimental model of bleomycin-induced lung fibrosis.

  12. Manifestation of cystic fibrosis transmembrane regulator (CFTR) in hepatic ductal structures and renal tubules of female rats with experimental cholestasis of pregnancy.

    Science.gov (United States)

    Aleksandrova, M I; Kushnareva, N S; Smirnova, O V

    2014-03-01

    Studies by the immunohistochemical method with semiquantitative analysis of images showed that hyperprolactinemia stimulated CFTR protein manifestation in the bile ducts of female rats, which was clearly expressed in experimental cholestasis of pregnancy. The expression of CFTR in the renal tubules was reduced in hyperprolactinemia under conditions of normal liver function and in cholestasis of pregnancy. Significant positive correlations between CFTR, prolactin receptor, and multiple drug resistance protein 3 were detected in the bile ducts, but not in the renal tubules. Presumably, prolactin has a direct effect on CFTR expression in the bile ducts and indirect effect in the renal tubules. Changes in CFTR protein manifestation in the hepatic ductal structures and renal tubules in experimental pregnancy cholestasis could aggravate the disease.

  13. Parasitologia. Trabajos aislados. (Trematodes-artropodos (contiuación

    Directory of Open Access Journals (Sweden)

    Alfonso Bonilla Naar

    1945-04-01

    Full Text Available (29 trabajos. 1888-1944. P Parasitosis intestinales (60 trabajos, 1876-1942. P Patología regional (44 trabajos. 1880-1943. Pelagra. (5 trabajos. 1884-1925. Peste bubónica (12 trabajos. 1899-1915. Pian o bubas (16 trabajos. 1910-1943.

  14. Alveolar inflammation in cystic fibrosis

    DEFF Research Database (Denmark)

    Ulrich, Martina; Worlitzsch, Dieter; Viglio, Simona

    2010-01-01

    BACKGROUND: In infected lungs of the cystic fibrosis (CF) patients, opportunistic pathogens and mutated cystic fibrosis transmembrane conductance regulator protein (CFTR) contribute to chronic airway inflammation that is characterized by neutrophil/macrophage infiltration, cytokine release...

  15. Optical methods in diagnostics of liver fibrosis via blood observation

    Science.gov (United States)

    Kruchinina, Margarita V.; Generalov, Vladimir M.; Atuchin, Victor V.; Kruchinin, Vladimir N.; Volodin, Vladimir A.; Gromov, Andrey A.; Rykhlitsky, Sergey V.

    2016-11-01

    A possible application of optical methods (dielectrophoresis, spectral and imaging ellipsometry, Fourier- transform infrared spectroscopy, Raman spectroscopy) for the early diagnostics in studies of red blood cells and serum in patients with the diffuse liver disease, with varying degrees of fibrosis, has been evaluated. As experimentally confirmed, the combined optical methods significantly improve the sensitivity, specificity and accuracy index in the diagnosis of both severe fibrosis and slight ulterior liver fibrosis. The identified optical methods diagnostic potential can be efficiently utilized in noninvasive screening evaluation of the stages of diffuse liver disease of various genesis.

  16. LAS METAMORFOSIS EN EL MUNDO DEL TRABAJO

    Directory of Open Access Journals (Sweden)

    Ricardo Antunes

    2000-01-01

    Full Text Available En este capítulo el autor aborda las distintas dimensiones que adquiere hoy el mundo del trabajo inscrito en el capitalismo contemporáneo: desproletarización del trabajo industrial mientras se presenta una notoria expansión de asalariados en el sector servicios; creciente heterogenización del ámbito laboral manifiesto fundamentalmente en la incorporación amplia de mujeres; subproletarización intensificada a través de la expansión del trabajo parcial, temporal, precario, subcontratado, "tercerizado".

  17. Las metamorfosis en el mundo del trabajo

    Directory of Open Access Journals (Sweden)

    Ricardo Antunes

    2000-04-01

    Full Text Available En este capítulo el autor aborda las distintas dimensiones que adquiere hoy el mundo del trabajo inscrito en el capitalismo contemporáneo: desproletarización del trabajo industrial mientras se presenta una notoria expansión de asalariados en el sector servicios; creciente heterogenización del ámbito laboral manifiesto fundamentalmente en la incorporación amplia de mujeres; subproletarización intensificada a través de la expansión del trabajo parcial, temporal, precario, subcontratado, “tercerizado”.

  18. Cystic Fibrosis: Diet and Nutrition

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Cystic Fibrosis: Diet and Nutrition KidsHealth / For Teens / Cystic Fibrosis: ... Enzyme Supplements Beating the Frustration Print What Is Cystic Fibrosis? At lunch, Lindsay often gets bored with having ...

  19. [Tropical endomyocardial fibrosis: Perspectives].

    Science.gov (United States)

    Lachaud, M; Lachaud, C; Sidi, D; Menete, A; Jouven, X; Marijon, E; Ferreira, B

    2018-04-01

    Tropical endomyocardial fibrosis (FET) is a leading cause of heart failure and the most common restrictive cardiomyopathy worldwide. Extensive fibrosis of the ventricular endocardium causing architectural distortion, impaired filling and valvular insufficiency define the disease. Confined to peculiar and limited geographical areas, the aetiology remains blurred and it carries a grim prognosis. The changing burden reported recently in some endemic areas and the refinement of diagnostic tools have emphasized alternative routes for understanding and treatment of the disease. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

  20. Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation.

    Science.gov (United States)

    Cheng, Tao; Liu, Qingbo; Zhang, Rui; Zhang, Ying; Chen, Jianfeng; Yu, Ronghuan; Ge, Gaoxiang

    2014-12-01

    Enzymes involved in collagen biosynthesis, including lysyl oxidase (LOX), have been proposed as potential therapeutic targets for idiopathic pulmonary fibrosis. LOX expression is significantly upregulated in bleomycin (BLM)-induced lung fibrosis, and knockdown of LOX expression or inhibition of LOX activity alleviates the lung fibrosis. Unexpectedly, treatment of the mice with LOX inhibitor at the inflammatory stage, but not the fibrogenic stage, efficiently reduces collagen deposition and normalizes lung architecture. Inhibition of LOX impairs inflammatory cell infiltration, TGF-β signaling, and myofibroblast accumulation. Furthermore, ectopic expression of LOX sensitizes the fibrosis-resistant Balb/c mice to BLM-induced inflammation and lung fibrosis. These results suggest that LOX is indispensable for the progression of BLM-induced experimental lung fibrosis by aggravating the inflammatory response and subsequent fibrosis process after lung injury. © The Author (2014). Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. All rights reserved.

  1. Nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Khurram, Misbah; Skov, Lone; Rossen, Kristian

    2007-01-01

    Nephrogenic systemic fibrosis (NSF) is a fibrotic disease seen in renal failure patients that may lead to severe physical disability. It has been demonstrated in recent studies that NSF can be caused by some gadolinium-containing MRI contrast agents. In this report we present one of a total of 26...

  2. Fibrosis and Cancer

    DEFF Research Database (Denmark)

    Cox, Thomas R.; Erler, Janine T.

    2016-01-01

    The relation between fibrosis and cancer has long been debated, specifically whether desmoplasia precedes, accompanies, or succeeds tumourigenesis, progression, and metastasis. Recent reports have published opposing data, adding to the perplexity. However, what is emerging is that it is likely th...

  3. Nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Marckmann, Peter

    2008-01-01

    PURPOSE OF REVIEW: The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. RECENT FINDINGS: Epidemiological and histochemical studies demonstrated that gado...

  4. Biomarcadores para fibrosis hepática, avances, ventajas y desventajas

    Directory of Open Access Journals (Sweden)

    A. Cequera

    2014-07-01

    En este trabajo se describen los biomarcadores empleados actualmente para el estudio de la fibrosis hepática en humanos, incluyendo sus ventajas y desventajas y la implementación de tecnologías de nueva generación, y la evaluación de las posibilidades de su empleo para el diagnóstico.

  5. Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis

    Science.gov (United States)

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C Arnold

    2015-01-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease that remains refractory to therapy. Despite increasing evidence that protease-activated receptor 2 (PAR-2) contributes to fibrosis, its importance in pulmonary fibrosis is under debate. We addressed whether PAR-2 deficiency persistently reduces bleomycin-induced pulmonary fibrosis or merely delays disease progression and whether pharmacological PAR-2 inhibition limits experimental pulmonary fibrosis. Bleomycin was instilled intranasally into wild-type or PAR-2–deficient mice in the presence/absence of a specific PAR-2 antagonist (P2pal-18S). Pulmonary fibrosis was consistently reduced in PAR-2–deficient mice throughout the fibrotic phase, as evident from reduced Ashcroft scores (29%) and hydroxyproline levels (26%) at d 28. Moreover, P2pal-18S inhibited PAR-2–induced profibrotic responses in both murine and primary human pulmonary fibroblasts (p bleomycin-treated wild-type mice but did not further reduce fibrosis in PAR-2–deficient mice. Importantly, P2pal-18S treatment starting even 7 d after the onset of fibrosis limits pulmonary fibrosis as effectively as when treatment was started together with bleomycin instillation. Overall, PAR-2 contributes to the progression of pulmonary fibrosis, and targeting PAR-2 may be a promising therapeutic strategy for treating pulmonary fibrosis. PMID:26147947

  6. Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis

    Directory of Open Access Journals (Sweden)

    Jamille Souza Fernandes

    2014-01-01

    Full Text Available A major issue with Schistosoma mansoni infection is the development of periportal fibrosis, which is predominantly caused by the host immune response to egg antigens. Experimental studies have pointed to the participation of monocytes in the pathogenesis of liver fibrosis. The aim of this study was to characterize the subsets of monocytes in individuals with different degrees of periportal fibrosis secondary to schistosomiasis. Monocytes were classified into classical (CD14++CD16−, intermediate (CD14++CD16+, and nonclassical (CD14+CD16++. The expressions of monocyte markers and cytokines were assessed using flow cytometry. The frequency of classical monocytes was higher than the other subsets. The expression of HLA-DR, IL-6, TNF-α, and TGF-β was higher in monocytes from individuals with moderate to severe fibrosis as compared to other groups. Although no differences were observed in receptors expression (IL-4R and IL-10R between groups of patients, the expression of IL-12 was lower in monocytes from individuals with moderate to severe fibrosis, suggesting a protective role of this cytokine in the development of fibrosis. Our data support the hypothesis that the three different monocyte populations participate in the immunopathogenesis of periportal fibrosis, since they express high levels of proinflammatory and profibrotic cytokines and low levels of regulatory markers.

  7. Radio universitaria: trabajo en red como imperativo

    Directory of Open Access Journals (Sweden)

    Tiziana Cavallo

    2014-01-01

    Full Text Available Trabajo en red es un concepto clave en la radio universitaria, tanto desde el punto de vista individual como del colectivo. A través de dos estudios de caso, enfocados en la radio universitaria de Italia y de Colombia, este artículo muestra cómo el trabajo en red ha sido decisivo para el fortalecimiento de su función, la ampliación de su impacto, la conformación de su identidad y el crecimiento de su visibilidad en las sociedades en las cuales desarrollan su labor.

  8. Trabajando en crear felicidad en el trabajo

    OpenAIRE

    Rodríguez González, Elena

    2016-01-01

    Treball final de Màster Universitari en Psicologia del Treball, de les Organitzacions i en Recursos Humans. Codi: SBE513. Curs acadèmic 2015-2016 Como su propio nombre indica, el siguiente trabajo es el final del camino recorrido en el Máster en Psicología del Trabajo, de las Organizaciones y en Recursos Humanos. En él resumo los conocimientos adquiridos a lo largo del mismo, así como las competencias conseguidas y el camino realizado para su obtención. Cada aspecto del máster ha ...

  9. Proceso de Trabajo y Sindicalismo Universitario

    Directory of Open Access Journals (Sweden)

    Jaime Puyana Ferreira

    2000-01-01

    Full Text Available El presente texto versa sobre el carácter específico del proceso de trabajo en las instituciones universitarias. A la luz de la diferenciación entre trabajo productivo e improductivo elaborada por Marx, se sostiene que la labor de las universidades públicas es de tipo improductivo, en el sentido de que, al menos en el corto plazo, no contribuye a la obtención de ganancias. Esto hace que los sindicatos en dichas instituciones carezcan de poder para lograr incrementos en los salarios, que se aparten de las políticas establecidas por el gobierno.

  10. [News in cystic fibrosis].

    Science.gov (United States)

    Delaisi, B

    2013-08-01

    The improvement over the last two decades in the treatment of cystic fibrosis led to an increase in life expectancy approaching 40 years at birth. Logically, the population of adult patients has been increasing and is currently 50% of patients followed in France. These therapeutic advances have justified the establishment in 2003 of a generalized neonatal screening for cystic fibrosis. The latest data of this screening show an incidence of CF of 1/5359 live births, far below the incidence of 1/2500 which was widely accepted twenty years ago. The performance of this screening is currently based on the dosage of trypsin immuno reactive, followed in case of exceeding the threshold of a search of the 30 most common mutations, can detect around 96% of 150 to 200 CF cases every year. Therefore, the possibility of a false negative of the screening cannot be excluded and evocative symptoms of cystic fibrosis, even for children born after 2003, will lead to prescribe a sweat test. While treatments available so far goal consequences of cystic fibrosis, a new therapeutic class to correct the functional defect of the mutated protein, called CFTR modulators, is emerging. Ivacaftor, leader of this new class, belonging to the category of "CFTR potentiator" got its access on the market in September 2012 for patients carrying the G551D mutation. New other molecules, named "CFTR correctors" which can have synergistic effect with ivacaftor and concern patients carrying the most common mutation--DF 508--are under development. Copyright © 2013. Published by Elsevier Masson SAS.

  11. Cambios en las relaciones de trabajo: paradojas y consecuencias en el actual mundo del trabajo

    Directory of Open Access Journals (Sweden)

    Verónica Andrade Jaramillo

    2014-01-01

    Full Text Available El objetivo del presente artículo es realizar una reflexión conceptual orientada a comprender los cambios acontecidos en el mundo del trabajo en las últimas décadas, por ser estos trascendentales para analizar la relación persona-trabajo. Dichos cambios se guían al menos a través de tres tendencias: la competición, la tecnologización y la globalización. Se mencionan las paradojas del actual mercado(s de trabajo, y se explicitan seis cambios concretos producto de las tendencias y las paradojas; entre estos se mencionan la precarización del trabajo y el cambio en el funcionamiento de las organizaciones; los cambios en las formas y manifestaciones del trabajo; el cambio en la forma de representarse el ser humano al respecto del trabajo; los cambios en los criterios para la inclusión (y exclusión y mantenimiento en el mercado de trabajo y la responsabilización del sujeto al respecto de su empleabilidad; los cambios en la configuración de la subjetividad y el lugar que el trabajo ocupa en ella incluyendo el establecimiento del contrato psicológico, la construcción de la carrera, la identidad, y la forma de representarse la agencia; y por último los cambios en la forma de gestionar el recurso humano al interior de las organizaciones. Se concluye que el estudio e intervención sobre el actual mundo del trabajo, requiere salir de visiones lineales y de causa-efecto, para contar con análisis reflexivos e intervenciones más pertinentes y atinadas, dada la complejidad que reviste hoy en día el mundo del trabajo.

  12. Genetics Home Reference: idiopathic pulmonary fibrosis

    Science.gov (United States)

    ... Twitter Home Health Conditions Idiopathic pulmonary fibrosis Idiopathic pulmonary fibrosis Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Idiopathic pulmonary fibrosis is a chronic, progressive lung disease. This condition ...

  13. Productividad, trabajo y salud: la perspectiva psicosocial

    Directory of Open Access Journals (Sweden)

    York Iván Puerto Barrios

    2007-07-01

    Full Text Available Con la opción de analizar las condiciones de trabajo en oficina, el texto realiza una sucinta pero precisa revisión de la conceptualización sobre productividad y consumo. Se documenta la relación contradictoria entre bienestar y rendimiento en el trabajo al identificar el riesgo de llevar al límite de sus capacidades la participación del trabajador como factor de productividad, ignorando que éste tiene además el rol de consumidor activo de bienes y servicios para que la producción tenga sentido. Se plantea que exigir al trabajador hasta su agotamiento puede mermar sustancialmente su doble condición de productor y consumidor. Específicamente, se presenta la perspectiva del trabajo en oficinas innovadas conceptual y tecnológicamente, con procesos laborales y patrones de desgaste y morbilidad de"nidos. El tiempo, el ritmo, la parcelación, el control del trabajo y la reestructuración en las organizaciones son, entre otros, factores que convergen para potenciar fenómenos de sobrecarga o subcarga mental con la consecuente aparición de estrés excedente y sus patologías asociadas.

  14. Homofobia en estudiantes de trabajo social

    Directory of Open Access Journals (Sweden)

    Adalberto Campo-Arias

    2013-01-01

    Full Text Available La homofobia es una actitud negativa ante personas homosexuales. Varios estudios infor - man altos niveles de homofobia en estudiantes universitarios. Estimar el nivel de homofo - bia en estudiantes de trabajo social. Se llevó a cabo una revisión sistemática de las inves - tigaciones formales disponibles en Ebsco, Imbiomed, Lilacs, MedLine, Ovid y ProQuest. Se incluyeron artículos publicados en español, inglés o portugués entre 1999 y 2010. Las palabras clave para la búsqueda fueron “homophobia”, “homosexuality”, “students” y “social work”. Se realizó un análisis descriptivo de los hallazgos. Un grupo de tres artícu - los se incluyeron en esta revisión. Entre el 6,5 y 77,4% de los estudiantes de trabajo social mostraron altos niveles de homofobia. Al menos uno de cada quince estudiantes de trabajo social informan altos niveles homofobia. En estudiantes colombianos de trabajo social es necesario investigar la presencia de homofobia.

  15. A mouse model for the cystic fibrosis delta F508 mutation

    NARCIS (Netherlands)

    J.H. van Doorninck (Hikke); P.J. French (Pim); E. Verbeek; R.H. Peters; H. Morreau (Hans); J. Bijman (Jan); B.J. Scholte (Bob)

    1995-01-01

    textabstractMost cystic fibrosis (CF) patients produce a mutant form (delta F508) of the cystic fibrosis transmembrane conductance regulator (CFTR), which is not properly processed in normal cells but is active as a chloride channel in several experimental systems. We used a double homologous

  16. Cambios en las relaciones de trabajo: paradojas y consecuencias en el actual mundo del trabajo

    OpenAIRE

    Verónica Andrade Jaramillo

    2014-01-01

    El objetivo del presente artículo es realizar una reflexión conceptual orientada a comprender los cambios acontecidos en el mundo del trabajo en las últimas décadas, por ser estos trascendentales para analizar la relación persona-trabajo. Dichos cambios se guían al menos a través de tres tendencias: la competición, la tecnologización y la globalización. Se mencionan las paradojas del actual mercado(s) de trabajo, y se explicitan seis cambios concretos producto de las tendencias y las paradoja...

  17. El ajuste de las características del trabajo como indicador de calidad del trabajo

    OpenAIRE

    Bayona Bohórquez, Jaime Andrés

    2017-01-01

    La calidad del trabajo es un fenómeno complejo que es de interés tanto para la academia, como para los profesionales en RRHH y organismos internacionales. Sin embargo, hoy día no hay consenso sobre las características que deberían integrar este fenómeno, ya que dependiendo del marco conceptual desde el cual se esté trabajando, se pueden incluir unas características y excluir otras. Desde la psicología del trabajo y las organizaciones, el estudio de la calidad del trabajo se ha enfocado en las...

  18. [Cystic fibrosis in 2008].

    Science.gov (United States)

    Durieu, I; Josserand, R Nove

    2008-11-01

    To describe the epidemiological, physiopathological, clinical and therapeutic knowledge concerning cystic fibrosis (CF). Important modifications in the health organization of the care concerning this orphan disease have been implemented in France. The life expectancy has dramatically increased, as well as the knowledge concerning the pathological structure and function of the CFTR gene and protein. This will lead to the development of emerging drug treatments for this lethal disease. The life expectancy is predicted to exceed 40 years for children born in the 2000s. As a result, there has been a tremendous growth of the adult population that reached 40% of the overall approximately 5000 patients included in the CF French registry (Observatoire National de la Mucoviscidose). Lung disease remains the primary cause of morbidity and mortality. The characteristic phenotypic presentation associates bronchial and rhinosinusal symptoms, pancreatic insufficiency and liver disease. Bronchial damage leads to progressive chronic respiratory insufficiency. Diabetes mellitus and osteoporosis frequently appears in adulthood. Neonatal screening has been implemented in France since 2002. It will prevent delayed diagnosis and its deleterious consequences. Some atypical cases of CF presenting only with one or two organ system involvement can be diagnosed in adulthood. Isolated chronic rhinosinusitis, bronchiectasis, congenital bilateral absence of vas deferens, recurrent pancreatitis, allergic bronchopulmonary aspergillosis, and some case of cholangitis may so revealed late form of cystic fibrosis. The health care is organized in cystic fibrosis centres. Despite gene discovery, treatment still remains symptomatic, based on intensive pulmonary and nutritional treatments. Challenges for new treatments are to correct the basic defect, either by gene therapy or by pharmacological modulation of the abnormal physiological processes.

  19. Imaging from cystic fibrosis

    International Nuclear Information System (INIS)

    Schmidt, H.; Posselt, H.G.

    2008-01-01

    Cystic fibrosis (CF) is the most frequent metabolic disorder with autosomal recessive inheritance in the Caucasian population. The gene defect is located on the long arm of chromosome 7. In Germany today, the actual median survival is 37 years. The genetic defect caused by chloride anion disturbances affects multiple body systems but the morbidity and mortality is due to lung disease. The secretion of highly viscous mucus promotes viral and bacterial pulmonary infections leading to airway obstruction and consecutive destruction of the lung parenchyma. This article will review and discuss both the clinical aspects of the disease and the diagnostic methods, referring in particular to new imaging strategies. (orig.)

  20. Serum markers of liver fibrosis

    DEFF Research Database (Denmark)

    Veidal, Sanne Skovgård; Bay-Jensen, Anne-Christine; Tougas, Gervais

    2010-01-01

    BACKGROUND: Fibrosis is a central histological feature of chronic liver diseases and is characterized by the accumulation and reorganization of the extracellular matrix. The gold standard for assessment of fibrosis is histological evaluation of a percutaneous liver biopsy. Albeit a considerable......-epitopes, may be targeted for novel biochemical marker development in fibrosis. We used the recently proposed BIPED system (Burden of disease, Investigative, Prognostic, Efficacy and Diagnostic) to characterise present serological markers. METHODS: Pubmed was search for keywords; Liver fibrosis, neo......, a systematic use of the neo-epitope approach, i.e. the quantification of peptide epitopes generated from enzymatic cleavage of proteins during extracellular remodeling, may prove productive in the quest to find new markers of liver fibrosis....

  1. El modelo de trabajo en equipo

    OpenAIRE

    Iñaki Rodríguez Cueto

    2008-01-01

    El modelo de trabajo en equipo constituye una herramienta basica en cualquier organizacion que quiera conseguir los objetivos propuestos y, ademas, lo quiera conseguir dentro de parametros de eficacia y calidad.En el entorno de la Comunidad Terapeutica cobra mayor importancia el dominio de saber trabajar en equipo debido a la necesidad de conjugar aspectos psico-terapeuticos, educativos, medicos e, incluso, administrativos a la hora de planificar el tratamiento a nivel grupal e individual.El ...

  2. EPISTEMOLOGÍA DEL TRABAJO SOCIAL

    Directory of Open Access Journals (Sweden)

    Francisco Javier Restrepo Giraldo

    2012-04-01

    Full Text Available El Trabajo Social como ciencia humana y social debe considerar en sus fundamentos el ingrediente epistemológico que le permita depurar su esencia y protagonismo dentro del marco de las ciencias. Por eso se hace necesaria una reflexión sobre los aspectos que hoy en día se cuestionan en Trabajo Social. Nos es familiar la apreciación de Alfred Schütz cuando afirma que "el objetivo primario de las Ciencias Sociales es lograr un conocimiento organizado de la realidad social. Quiero que se entienda por realidad social la suma de todos los objetos y sucesos dentro del mundo social cultural, tal como lo experimenta el pensamiento de sentido común entre sus semejantes, con quienes los vinculan múltiples relaciones de interacción". Pues bien, el propósito de este estudio es abordar lo que le compete como específico al Trabajo Social en su fundamentación epistemológica.

  3. Nephrogenic systemic fibrosis

    International Nuclear Information System (INIS)

    Samtleben, W.

    2007-01-01

    A scleromyxedema-like disease was recognized in 1997. In 2000 this disorder was first published and termed nephrogenic fibrosing dermopathy because all patients had advanced renal failure. In 2006 it was discovered that the patients had a history of a preceding contrast-enhanced magnetic resonance imaging (MRI). All patients had acute or chronic severe renal insufficiency with a glomerular filtration rate (GFR) 2 . So far a total of about 215 patients with this new skin disorder have been reported to international registries. The skin thickening has a typical histology and begins in the peripheral extremities and progresses proximally, including also the abdominal wall and the head in some patients. NSF involves not only the skin, but also the muscles and other organs (e.g., lungs, heart, eyes) in some patients. Therefore the term nephrogenic systemic fibrosis (NSF) was introduced. Skin fibrosis and sclerosis are usually progressive with disabling contractures of involved joints (knees, hands, feet). NSF may be lethal in up to 28% of patients. Spontaneous remissions are rare. No generally accepted treatment is available. So far, the pathogenesis is not well understood. One hypothesis supposes a role of gadolinium liberated from the contrast agents. As patients with acute or chronic advanced renal failure (GFR 2 ) including those with hepatorenal dysfunctions are at high risk to develop NSF after exposure to gadolinium-based contrast agents, contrast-enhanced MRI should be avoided in this group and alternative diagnostic procedures should be used whenever possible. (orig.) [de

  4. Calprotectin in cystic fibrosis.

    Science.gov (United States)

    Rumman, Nisreen; Sultan, Mutaz; El-Chammas, Khalil; Goh, Vi; Salzman, Nita; Quintero, Diana; Werlin, Steven

    2014-05-29

    There is increasing evidence that intestinal inflammation plays a major role in gastrointestinal symptoms in cystic fibrosis (CF). Fecal calprotectin is a marker that is elevated in several gastrointestinal inflammatory diseases, but little is known about its value in CF. We aimed to look for associations of elevated fecal calprotectin among CF patients and whether its level correlates with the clinical manifestations of CF. A single stool specimen was collected from 62 patients with CF. Fecal calprotectin was measured using the commercially available ELISA kits (PhiCal™ test). Clinical data were collected from patients' records and CF registry. There were no significant differences between CF patients with normal and abnormal fecal calprotectin levels. However, patients who were not receiving inhaled antibiotics had higher fecal calprotectin levels than those who were. Elevated fecal calprotectin may not accurately predict intestinal inflammation in CF. However, the fact that it was elevated in both pancreatic sufficient and insufficient groups supports the concept of "cystic fibrosis enteropathy" regardless of the pancreatic status.

  5. Thoracic periaortal fibrosis and Ormond's disease

    International Nuclear Information System (INIS)

    Kacl, G.M.; Bino, M.; Salomon, F.; Risti, B.; Marincek, B.

    1995-01-01

    Two cases of thoracic periaortal fibrosis as a manifestation of retroperitoneal fibrosis (Ormond's disease) are shown on CT and MRI. Thoracic periaortal fibrosis can result in an inflammatory aneurysmo with chronic dissection. Manifestation of thoracic periaortal fibrosis may typically occur intermittently over decades. (orig.) [de

  6. ¿Es necesaria la reconstrucción de la conjuntiva?: Trabajo experimental en conejos albinos para evaluar la neogénesis de la conjuntiva Is necessary the reconstruction of the conjunctiva?: Experimental research in albino rabbits to demostrate conjunctiva regeneration

    Directory of Open Access Journals (Sweden)

    E. A. Moretti

    2007-03-01

    Full Text Available En los defectos de espesor total del párpado inferior de gran magnitud, siempre ha sido regla de oro la reconstrucción de la lamela posterior (tarso y conjuntiva palpebral. Esto es debido a que el tono del músculo orbicularis oculi no alcanza a mantener el soporte necesario para resistir la acción de la gravedad y/o contractura cicatricial. Además la ausencia de conjuntiva provocaría lesiones sobre la córnea ocular. Es por ello que el empleo de injertos compuestos condromucosos ha sido insustituible. El presente trabajo de investigación fue realizado en 20 conejos albinos con el objeto de evaluar la posibilidad de emplear cartílago auricular para la reconstrucción del tarso sin colocación de mucosa a modo de conjuntiva sobre dicho cartílago. Los resultados obtenidos permiten confirmar por diferentes tinciones histológicas sobre biopsias comparadas con zonas testigo, el crecimiento de tejido conjuntival sobre el pericondrio sin provocar lesiones oculares (neogénesis de conjuntiva. Los hallazgos encontrados provocan importantes y sustanciales cambios en la cirugía reconstructiva del párpado inferior debido a que de esta manera, no sería necesaria la reconstrucción de la conjuntiva palpebral, siendo útil exclusivamente la colocación de cartílago.In a full-thickness defect of a lower eyelid, as a general rule, is mandatory to reconstruct the tarsal plate and the conjunctiva. The reason is that the orbicularis oculi muscle cannot support the effects of gravity and/or cicatricial contracture. The abscense of conjunctiva provokes corneal lesions. Therefore, a chondromucosal graft is obligatory. This research has been performed in 20 albino rabbits to evaluate the possibility of tarsal plate reconstruction with conchal cartilage graft without mucosa. The results of the research have demonstrated, by different histological biopsies, that the raw surface of the perichondrium is epithelized with a new conjunctiva (neoconjunctiva. These

  7. Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats

    NARCIS (Netherlands)

    W.A. Dik (Willem); R.J. McAnulty; M.A. Versnel (Marjan); B.A. Naber (Brigitta); L.J.I. Zimmermann (Luc); G.J. Laurent; S.E. Mutsaers (Steven)

    2003-01-01

    textabstractBACKGROUND: Corticosteroids are routinely used in patients with pulmonary fibrosis. The timing for initiation of treatment is likely to be crucial for corticosteroids to exert an antifibrotic effect. Experimental studies in animals have examined the effect of

  8. Gastrointestinal Manifestations of Cystic Fibrosis

    Science.gov (United States)

    2016-01-01

    Cystic fibrosis has historically been considered a pulmonary disease, but with the increasing life expectancy of these patients, gastrointestinal manifestations are becoming more important. Furthermore, nutritional status is closely linked to pulmonary function and, thus, overall mortality. This article discusses gastrointestinal manifestations (which involve nutritional, pancreatic, hepatobiliary, and, in particular, gastrointestinal tract issues) of cystic fibrosis as well as management of the disease. In addition, the article discusses studies that have been critical to our understanding of gastrointestinal manifestations of cystic fibrosis. PMID:27330503

  9. Nephrogenic systemic fibrosis.

    LENUS (Irish Health Repository)

    Kennedy, C

    2010-11-05

    Nephroaenic systemic fibrosis (NSF) is a potentiallv fatal dermatiological condition found exclusively in patients with advanced renal I failure. There is minimal literature regarding the epidemiology and outcomes of patients with NSF in Ireland. A retrospective chart review was performed for all patients with NSF in Ireland. Ireland\\'s experience with the disease was examined in light of international reports. There have been three cases of NSF in Ireland; an area which serves 1915 dialysis patients--giving a point prevalence among Irish end-stage kidney disease patients of 0.002. There was a large variation in disease severity between the three patients. All three patients had significant exposure to gadolinium chelate. Caution with gadolinium administration must be exercised in patients with advanced renal failure.

  10. Nephrogenic systemic fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Diego R. [Emory University Hospital, Department of Radiology, Atlanta, GA (United States)

    2008-01-15

    Nephrogenic systemic fibrosis (NSF) is a dermatological fibrosing disease with potential systemic manifestations resulting in mild to severe symptoms including joint contractures. NSF can be lethal in a subset of cases. It has been recently observed that almost all patients with NSF have had severe renal insufficiency and have received prior administrations of gadolinium-based contrast agents (GBCA). This review will focus on the specific evidence from a retrospective study performed at our center in combination with the general experience available. Conclusions summarize our current understanding of NSF. Recommendations are provided for use of GBCA in clinical MRI practice. Conclusions and recommendations include that the risk of inducing NSF is related to higher-dose administrations of GBCA and that there are differences in risk related to differences in gadolinium-chelate formulation, with the highest relative risk associated with gadodiamide (Omniscan, Nycomed Amersham, GE Healthcare, Piscataway, N.J.). (orig.)

  11. Profile of cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Mona M. El-Falaki

    2014-09-01

    Full Text Available It was generally believed that Cystic fibrosis (CF is rare among Arabs; however, the few studies available from Egypt and other Arabic countries suggested the presence of many undiagnosed patients. The aim of the present study was to determine the frequency of CF patients out of the referred cases in a single referral hospital in Egypt. A total of 100 patients clinically suspected of having CF were recruited from the CF clinic of the Allergy and Pulmonology Unit, Children’s Hospital, Cairo University, Egypt, throughout a 2 year period. Sweat chloride testing was done for all patients using the Wescor macroduct system for collection of sweat. Quantitative analysis for chloride was then done by the thiocyanate colorimetric method. Patients positive for sweat chloride (⩾60 mmol/L were tested for the ΔF508 mutation using primer specific PCR for cystic fibrosis transmembrane conductance regulator (CFTR gene. Thirty-six patients (36% had a positive sweat chloride test. The main clinical presentations in patients were chronic cough in 32 (88.9%, failure to thrive in 27 (75%, steatorrhea in 24 (66.7%, and hepatobiliary involvement in 5 (13.9%. Positive consanguinity was reported in 50% of CF patients. Thirty-two patients were screened for ΔF508 mutation. Positive ΔF508 mutation was detected in 22 (68.8% patients, 8 (25% were homozygous, 14 (43.8% were heterozygous, and 10 (31.3% tested were negative. CF was diagnosed in more than third of patients suspected of having the disease on clinical grounds. This high frequency of CF among referred patients indicates that a high index of suspicion and an increasing availability of diagnostic tests lead to the identification of a higher number of affected individuals.

  12. Clima de trabajo y organizaciones que aprenden

    OpenAIRE

    Martín Bris, Mario

    2000-01-01

    Las organizaciones educativas son entendidas como el lugar en el que confluyen todos los elementos y los factores del sistema, y están ubicadas en contextos complejos y cambiantes con los que deben convivir y a los que deben respuestas. El clima o ambiente de trabajo constituye uno de los factores determinantes y facilita, no sólo los procesos organizativos y de gestión, sino también de innovación y cambio. Les organitzacions educatives són enteses com el lloc on conflueixen tots els eleme...

  13. Trabajo Fin de Máster

    OpenAIRE

    Adánez Climent, Ángela

    2015-01-01

    Treball Final del Màster Universitari en Psicologia del Treball, de les Organitzacions i en Recursos Humans (Pla de 2014) (Presencial). Codi: SBE013. Curs acadèmic 2014-2015 Durante las últimas décadas, la creciente globalización de la sociedad y de la economía, los fuertes desarrollos de la tecnología de la información y la comunicación y los cambios demográficos, sociales y culturales han producido importantes transformaciones en el mundo del trabajo, en las organizaciones y en ...

  14. Genetics Home Reference: retroperitoneal fibrosis

    Science.gov (United States)

    ... Retroperitoneal fibrosis: a clinicopathologic study with respect to immunoglobulin G4. Am J Surg Pathol. 2009 Dec;33(12):1833-9. Citation on PubMed More from Genetics Home Reference Bulletins March is Trisomy Awareness Month ...

  15. Molecular Diagnosis of Cystic Fibrosis.

    Science.gov (United States)

    Deignan, Joshua L; Grody, Wayne W

    2016-01-01

    This unit describes a recommended approach to identifying causal genetic variants in an individual suspected of having cystic fibrosis. An introduction to the genetics and clinical presentation of cystic fibrosis is initially presented, followed by a description of the two main strategies used in the molecular diagnosis of cystic fibrosis: (1) an initial targeted variant panel used to detect only the most common cystic fibrosis-causing variants in the CFTR gene, and (2) sequencing of the entire coding region of the CFTR gene to detect additional rare causal CFTR variants. Finally, the unit concludes with a discussion regarding the analytic and clinical validity of these approaches. Copyright © 2016 John Wiley & Sons, Inc.

  16. La normalidad del trabajo, empleos normales y vidas de trabajo: razones para trabajar

    OpenAIRE

    Grassi,Estela

    2009-01-01

    ¿Cómo se trabaja y se vive hoy y qué razones nos motivan para hacerlo? El artículo presenta hipótesis al respecto, teniendo como referencia el empleo formalmente instituido, contemplado por la legislación laboral, modalidad que no agota el hecho de que la mayoría de las personas "vive de su trabajo", cualquiera sea la consideración que sus capacidades reciban.Se detiene en la idea de normalidad, distinguiendo entre el nivel de los principios estructurales (el trabajo como amalgama de la socie...

  17. Patogenesis of pipe-stem fibrosis of the liver (experimental observation on murine Schistosomiasis Patogenia da fibrose "pipe-stem" do fígado (observações experimentais na esquistossomose murina

    Directory of Open Access Journals (Sweden)

    Zilton A. Andrade

    1987-09-01

    Full Text Available Mice infected with 30 cercariae of Schistosoma mansoni developed portal and septal fibrosis due to the massive and concentrated deposition of eggs in the periportal areas which occurred following the 16th week after infection. The lesion resembled pipe-stem fibrosis seen in human hepatosplenic schistosomiasis in the following characters: portal fibrosis interconnecting portal spaces as well as portal spaces and central canals; portal inflammation; periovular granulomas; vascular obstruction and telangiectasia. The liver parenchyma maintained its normal architecture. Vascular injection techniques with Indian ink and vinylite revealed that the portal system developed numerous dilated collateral venules coming from the large and medium-sized portal branches, about 10 weeks after schistosome infection. The lodging of schistosome eggs into these collaterals resulted in granulomatous inflammation and fibrosis along all the portal tracts, thus forming the pipe-stem lesion. Although not readily demonstrable grossly, the pipe-stem fibrosis of murine schistosomiasis has many similarities with the human lesion and can be considered to have the same basic pathogenesis.Camundongos infectados com 30 cercárias do Schistosoma mansoni desenvolveram fibrose porta em virtude de um depósito progressivo e concentrado de ovos na região periportal, o que aconteceu a partir da 16ª semana da infecção. Esta fibrose certas características da chamada fibrose "pipe-stem" do homem vista na forma hepatoesplênica da esquistossomose, tais como obstrução das radiculas porta, telangiectasia, conexão fibrosa entre espaços porta e entre estes e veias centrais, além de certo grau de fibrose septal, presença dos granulomas em várias fases evolutivas e reação inflamatória crônica difusa, enquanto o parênquima hepático mantinha a sua estrutura lobular normal. As técnicas de injeção vascular com tinta da China e com vinilite feitas no sistema porta permitiram a

  18. Therapeutic targets in liver fibrosis.

    Science.gov (United States)

    Fallowfield, Jonathan A

    2011-05-01

    Detailed analysis of the cellular and molecular mechanisms that mediate liver fibrosis has provided a framework for therapeutic approaches to prevent, slow down, or even reverse fibrosis and cirrhosis. A pivotal event in the development of liver fibrosis is the activation of quiescent hepatic stellate cells (HSCs) to scar-forming myofibroblast-like cells. Consequently, HSCs and the factors that regulate HSC activation, proliferation, and function represent important antifibrotic targets. Drugs currently licensed in the US and Europe for other indications target HSC-related components of the fibrotic cascade. Their deployment in the near future looks likely. Ultimately, treatment strategies for liver fibrosis may vary on an individual basis according to etiology, risk of fibrosis progression, and the prevailing pathogenic milieu, meaning that a multiagent approach could be required. The field continues to develop rapidly and starts to identify exciting potential targets in proof-of-concept preclinical studies. Despite this, no antifibrotics are currently licensed for use in humans. With epidemiological predictions for the future prevalence of viral, obesity-related, and alcohol-related cirrhosis painting an increasingly gloomy picture, and a shortfall in donors for liver transplantation, the clinical urgency for new therapies is high. There is growing interest from stakeholders keen to exploit the market potential for antifibrotics. However, the design of future trials for agents in the developmental pipeline will depend on strategies that enable equal patient stratification, techniques to reliably monitor changes in fibrosis over time, and the definition of clinically meaningful end points.

  19. Effect of iron, taurine and arginine on rat hepatic fibrosis

    International Nuclear Information System (INIS)

    Song Liangwen; Wang Dewen; Cui Xuemei

    1997-01-01

    Objective: The promotion role of iron on pathogenesis of hepatic fibrosis and the protective role of taurine and L-arginine against hepatic fibrosis were studied. Method: The model of rat radiation hepatic fibrosis was used. Experimental rats were divided into 0 Gy, 30 Gy, 30 Gy + iron, 30 Gy + taurine and 30 Gy + L-arginine groups. Serum iron, liver tissue hydroxyproline (Hyp) and malondialdehyde (MDA) were measured one and three months respectively after irradiation of hepatic tissue, production and distribution characteristics of hepatic tissue type I and III collagen were observed with a polarizing microscope. Results: Administration of iron agent could significantly increase hepatic tissue MDA content and serum iron concentration, one month after irradiation, hepatic tissue Hyp in 30 Gy + iron group began to increase, and collagen in hepatic tissue obviously increased. Taurine and L-arginine could reduce serum iron concentration and decrease production of hepatic fissure Hyp. Conclusion: Exogenous iron agent could promote early development of radiation hepatic fibrosis; taurine and arginine could diminish pathologic alteration of hepatic fibrosis to a certain extent

  20. Idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Noble Paul W

    2008-03-01

    Full Text Available Abstract Idiopathic pulmonary fibrosis (IPF is a non-neoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known provocation. IPF is a rare disease which affects approximately 5 million persons worldwide. The prevalence is estimated to be slightly greater in men (20.2/100,000 than in women (13.2/100,000. The mean age at presentation is 66 years. IPF initially manifests with symptoms of exercise-induced breathless and dry coughing. Auscultation of the lungs reveals early inspiratory crackles, predominantly located in the lower posterior lung zones upon physical exam. Clubbing is found in approximately 50% of IPF patients. Cor pulmonale develops in association with end-stage disease. In that case, classic signs of right heart failure may be present. Etiology remains incompletely understood. Some environmental factors may be associated with IPF (cigarette smoking, exposure to silica and livestock. IPF is recognized on high-resolution computed tomography by peripheral, subpleural lower lobe reticular opacities in association with subpleural honeycomb changes. IPF is associated with a pathological lesion known as usual interstitial pneumonia (UIP. The UIP pattern consists of normal lung alternating with patches of dense fibrosis, taking the form of collagen sheets. The diagnosis of IPF requires correlation of the clinical setting with radiographic images and a lung biopsy. In the absence of lung biopsy, the diagnosis of IPF can be made by defined clinical criteria that were published in guidelines endorsed by several professional societies. Differential diagnosis includes other idiopathic interstitial pneumonia, connective tissue diseases (systemic sclerosis, polymyositis, rheumatoid arthritis, forme fruste of autoimmune disorders, chronic hypersensitivity pneumonitis and other environmental (sometimes occupational exposures. IPF is typically progressive and leads to significant

  1. El déficit de trabajo decente en Colombia

    OpenAIRE

    Jaramillo Jassir, Ivan Daniel; Guataquí, Juan; Hartmann Cortés, Kevin; Valdés Rocha, Juan Diego

    2015-01-01

    Esta investigación tiene como objetivo principal analizar, mediante el enfoque multidimensional propuesto por la Organización Internacional del Trabajo, el cumplimiento de los estándares que permiten inferir la calidad de trabajo en Colombia y su adecuación al modelo de trabajo decente. La Organización Internacional del Trabajo formuló el concepto de trabajo decente como proyecto prospectivo de los estándares laborales en 1999, a través del entonces director general Juan Somavia como estrateg...

  2. Breakdown in Breathing: The Complexities of Cystic Fibrosis

    Science.gov (United States)

    ... Healthier Lungs in Kids Wise Choices Living with Cystic Fibrosis In between checkups, practice good self-care and ... Links What Is Cystic Fibrosis? Learning About Cystic Fibrosis NIH Cystic Fibrosis Fact Sheet Genetic and Rare Diseases Information ...

  3. Pulmonary CCR2+CD4+T cells are immune regulatory and attenuate lung fibrosis development.

    Science.gov (United States)

    Milger, Katrin; Yu, Yingyan; Brudy, Eva; Irmler, Martin; Skapenko, Alla; Mayinger, Michael; Lehmann, Mareike; Beckers, Johannes; Reichenberger, Frank; Behr, Jürgen; Eickelberg, Oliver; Königshoff, Melanie; Krauss-Etschmann, Susanne

    2017-11-01

    Animal models have suggested that CCR2-dependent signalling contributes to the pathogenesis of pulmonary fibrosis, but global blockade of CCL2 failed to improve the clinical course of patients with lung fibrosis. However, as levels of CCR2 + CD4 + T cells in paediatric lung fibrosis had previously been found to be increased, correlating with clinical symptoms, we hypothesised that distinct CCR2 + cell populations might either increase or decrease disease pathogenesis depending on their subtype. To investigate the role of CCR2 + CD4 + T cells in experimental lung fibrosis and in patients with idiopathic pulmonary fibrosis and other fibrosis. Pulmonary CCR2 + CD4 + T cells were analysed using flow cytometry and mRNA profiling, followed by in silico pathway analysis, in vitro assays and adoptive transfer experiments. Frequencies of CCR2 + CD4 + T cells were increased in experimental fibrosis-specifically the CD62L - CD44 + effector memory T cell phenotype, displaying a distinct chemokine receptor profile. mRNA profiling of isolated CCR2 + CD4 + T cells from fibrotic lungs suggested immune regulatory functions, a finding that was confirmed in vitro using suppressor assays. Importantly, adoptive transfer of CCR2 + CD4 + T cells attenuated fibrosis development. The results were partly corroborated in patients with lung fibrosis, by showing higher percentages of Foxp3 + CD25 + cells within bronchoalveolar lavage fluid CCR2 + CD4 + T cells as compared with CCR2 - CD4 + T cells. Pulmonary CCR2 + CD4 + T cells are immunosuppressive, and could attenuate lung inflammation and fibrosis. Therapeutic strategies completely abrogating CCR2-dependent signalling will therefore also eliminate cell populations with protective roles in fibrotic lung disease. This emphasises the need for a detailed understanding of the functions of immune cell subsets in fibrotic lung disease. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights

  4. Expression and distribution of connexin 32 in rat liver with experimentally induced fibrosis Expressão e distribuição da conexina 32 em fígados de ratos com fibrose induzida experimentalmente

    Directory of Open Access Journals (Sweden)

    Alexandro dos S. Rodrigues

    2009-04-01

    Full Text Available The connexin 32 (Cx32 is a protein that forms the channels that promote the gap junction intercellular communication (GJIC in the liver, allowing the diffusion of small molecules through cytosol from cell-to-cell. Hepatic fibrosis is characterized by a disruption of normal tissue architeture by cellular lesions, and may alter the GJIC. This work aimed to study the expression and distribution of Cx32 in liver fibrosis induced by the oral administration of dimethylnitrosamine in female Wistar rats. The necropsy of the rats was carried out after five weeks of drug administration. They presented a hepatic fibrosis state. Sections from livers with fibrosis and from control livers were submitted to immunohistochemical, Real Time-PCR and Western-Blot analysis to Cx32. In fibrotic livers the Cxs were diffusely scattered in the cytoplasm, contrasting with the control livers, where the Cx32 formed junction plaques at the cell membrane. Also it was found a decrease in the gene expression of Cx32 without reduction in the protein quantity when compared with controls. These results suggest that there the mechanism of intercellular communication between hepatocytes was reduced by the fibrotic process, which may predispose to the occurrence of a neoplastic process, taken in account that connexins are considered tumor suppressing genes.A conexina 32 (Cx32 é uma proteína que constitui os canais que promovem as comunicações intercelulares via junções comunicantes (CIJC no fígado, permitindo difusão de pequenas moléculas citoplasmáticas de uma célula à outra. A fibrose hepática caracteriza-se pela alteração da arquitetura normal do fígado e podem alterar as CIJCs. O objetivo deste trabalho foi estudar a expressão e distribuição de Cx32 na fibrose hepática. O objetivo do presente trabalho foi estudar a expressão e distribuição da Cx32 em fígados com fibrose induzida pela administração oral de dimetilnitrosamina em fêmeas de ratos Wistar. A

  5. Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model

    Directory of Open Access Journals (Sweden)

    Arianne van Koppen

    2018-01-01

    Conclusions: An early predictive molecular signature was identified that marked the active profibrotic process before histopathologic fibrosis becomes manifest. Early detection of the onset of NASH and fibrosis enables identification of novel blood-based biomarkers to stratify patients at risk, development of new therapeutics, and help shorten (preclinical experimental time frames.

  6. ¿Infancia sin trabajo o Infancia trabajadora? Perspectivas sobre el trabajo infantil

    Directory of Open Access Journals (Sweden)

    María Eugenia Rausky

    2009-01-01

    Full Text Available Desde diferentes instituciones y actores circulan discursos en relación con el trabajo infantil; comúnmente los mismos suelen estar teñidos de referencias morales negativas, sustentadas en la idea de que la ejecución de actividades laborales por parte de los niños y las niñas va en detrimento de su bienestar y de lo esperado para dicha etapa de la vida. En el presente artículo me propongo analizar uno de esos discursos, en particular aquél que han construido los organismos no gubernamentales sobre el trabajo infantil, revisando tanto los desarrollos conceptuales como las propuestas de política y las posiciones asumidas (abolicionismo versus proteccionismo frente al trabajo de las personas menores. ¿Qué consideraciones elaboran en torno a las actividades laborales de niños y niñas? ¿Qué concepciones sobre la niñez subyacen? ¿Qué líneas de acción proponen frente a la problemática? Cada uno de ellos está cargado de valores y atravesado por conflictos ideológicos en torno a lo que se considera apropiado para la niñez. Para llevar a cabo el análisis, seleccioné las visiones que sostienen organismos con miradas contrapuestas y que han destinado gran atención a la temática que aquí nos ocupa. Por un lado, la Organización Internacional del Trabajo y el Fondo de las Naciones Unidas para la Infancia, que plantean la erradicación del trabajo infantil. Por otro lado, la perspectiva que plantea el Instituto de Formación para Educadores de Jóvenes, Adolescentes y Niños Trabajadores de América Latina y el Caribe (Ifejant, institución que apoya y promueve el trabajo infantil.

  7. Nephrogenic systemic fibrosis

    Directory of Open Access Journals (Sweden)

    Bhushan Madke

    2011-01-01

    Full Text Available Nephrogenic systemic fibrosis (NSF is a relatively new fibrosing disorder which has caught the attention of various specialities in the past decade. NSF is an extremely disabling and often painful condition, affecting up to 13% of the individuals with chronic kidney disease. The administration of a gadolinium chelate contrast agent has been reported to induce the development of NSF, particularly in patients who have acute or chronic renal disease with a glomerular filtration rate (GFR lower than 30-mL/min/1.73 m 2 and in those with acute renal insufficiency. Mass spectroscopy studies have demonstrated particles of gadolinium in the lesional tissue. The exact pathogenesis of this curious sclerosing condition is unknown. The role of the aberrant targeting of ′circulating fibrocytes′ to the peripheral tissues and viscera has been hypothesized. NSF has distinct clinicopathological features in the setting of renal failure and needs to be looked upon as a new entity on the block. The condition is characterized by irregular indurated plaques, with amoeba-like projections and islands of sparing, chiefly on the trunk and extremities. Flexion contractures of fingers, knees, and elbow joints are known to occur in advanced cases of NSF. The course is frequently associated with painful episodes and loss of ambulation. Histopathology shows haphazard arrangement of thickened bundles of collagen, varying amount of mucin, and increased population of fibroblast-like cells in the dermis. Immunohistochemistry shows increased deposition of type-I procollagen and CD 34+ cells having fibroblastic activity. The condition is refractory to treatment with corticosteroids and immunosuppressive agents. Various modalities of therapy such as UVA1 phototherapy, imatinib mesylate, photodynamic therapy, plasmapheresis, extracorporeal photochemotherapy, and high-dose intravenous immunoglobulin have shown a moderate degree of improvement in skin thickness scores. A prudent

  8. Cystic fibrosis in adults

    Directory of Open Access Journals (Sweden)

    C. Damas

    2007-05-01

    Full Text Available The authors reviewed adult cystic fibrosis patients followed in the Pulmonology Unit from 1994-2004 (n = 8, five female and three male, aged 20-34 years old (median = 27 years. Patients were diagnosed at 18 months - 31 years old by sweat testing (positive in six patients and genotyping (four patients homozygous for ΔF508 mutation.Respiratory involvement was characterised by sinusitis and bronchiectasis. Pulmonary involvement was accompanied by functional abnormalities and gas exchange impairment in the majority of the patients. Bronchial tree was colonised permanently in five patients: Pseudomonas aeruginosa in four and Staphilococcus aureus in four (three patients affected by both agents simultaneously.The main causes of exacerbation were respiratory infections and haemoptysis.Non-respiratory involvement was variable. Four patients had digestive involvement (one with hepatic cirrhosis, one had renal failure and only one had a sperm count to document infertility. Four patients had osteopaenia.Treatment included chest physiotherapy, bronchodilators, dornase alfa, mucolytics, digestive enzymes, vitamins, antibiotics and oxygen therapy.At review, one had left follow-up, one had died, one was awaiting lung transplant and the others evidenced no difference in clinical characteristics.In this group of patients the severity of the pulmonary disease was not related to a late diagnosis. It can be explained by the diversity of cystic fibrosis presentation in adults Resumo: Os autores efectuaram uma revisão de doentes adultos com fibrose quística (FQ, seguidos na consulta de Pneumologia no período de 1994-2004 (n = 8: cinco mulheres e três homens, com idades compreendidas entre 20 e 34 anos (mediana  =  27 anos, cuja idade de diagnóstico variou entre os 18 meses e os 31 anos.O diagnóstico foi obtido por prova de suor (positiva em seis doentes e estudo genético (homozigotia para a mutação ΔF508 em

  9. Pathological assessment of liver fibrosis regression

    Directory of Open Access Journals (Sweden)

    WANG Bingqiong

    2017-03-01

    Full Text Available Hepatic fibrosis is the common pathological outcome of chronic hepatic diseases. An accurate assessment of fibrosis degree provides an important reference for a definite diagnosis of diseases, treatment decision-making, treatment outcome monitoring, and prognostic evaluation. At present, many clinical studies have proven that regression of hepatic fibrosis and early-stage liver cirrhosis can be achieved by effective treatment, and a correct evaluation of fibrosis regression has become a hot topic in clinical research. Liver biopsy has long been regarded as the gold standard for the assessment of hepatic fibrosis, and thus it plays an important role in the evaluation of fibrosis regression. This article reviews the clinical application of current pathological staging systems in the evaluation of fibrosis regression from the perspectives of semi-quantitative scoring system, quantitative approach, and qualitative approach, in order to propose a better pathological evaluation system for the assessment of fibrosis regression.

  10. Computed tomography of cystic pancreatic fibrosis

    International Nuclear Information System (INIS)

    Brachlow, M.; Zaunbauer, W.; Haertel, M.

    1984-01-01

    The computer tomographic appearances of atrophic and lipomatous degeneration of the pancreas in cystic pancreatic fibrosis are described. CT exploration of the pancreas in recommended, particularly in differential diagnostic aspects of cystic fibrosis. (orig.) [de

  11. Cystic Fibrosis (CF) Respiratory Screen: Sputum

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Cystic Fibrosis (CF) Respiratory Screen: Sputum KidsHealth / For Parents / Cystic Fibrosis (CF) Respiratory Screen: Sputum What's in this article? ...

  12. Non-cystic fibrosis bronchiectasis.

    Science.gov (United States)

    Neves, Paulo C; Guerra, Miguel; Ponce, Paulo; Miranda, José; Vouga, Luís

    2011-12-01

    Bronchiectasis is characterized by irreversible widening of the medium-sized airways, with inflammation, chronic bacterial infection and destruction of the bronchial walls. Exercise or inspiratory muscle training may improve quality of life and exercise endurance in people with non-cystic fibrosis bronchiectasis. Prolonged-use antibiotics improve clinical response rates, but may not reduce exacerbation rates or lung function. Surgery is often considered for people with extreme damage to one or two lobes of the lung who are at risk for severe infection or bleeding. In this review, the authors will focus on non-cystic fibrosis bronchiectasis, pointing out the differences in management when compared with the cystic fibrosis context, with special emphasis on surgical management.

  13. Serum markers of liver fibrosis

    DEFF Research Database (Denmark)

    Veidal, Sanne Skovgård; Bay-Jensen, Anne-Christine; Tougas, Gervais

    2010-01-01

    BACKGROUND: Fibrosis is a central histological feature of chronic liver diseases and is characterized by the accumulation and reorganization of the extracellular matrix. The gold standard for assessment of fibrosis is histological evaluation of a percutaneous liver biopsy. Albeit a considerable...... effort have been invested in finding alternative non-invasive approaches, these have not been sufficiently successful to replace biopsy assessment. AIM: To identify the extracellular matrix proteins of interest, that as protein degradation fragments produced during extracellular matrix metabolism neo......, a systematic use of the neo-epitope approach, i.e. the quantification of peptide epitopes generated from enzymatic cleavage of proteins during extracellular remodeling, may prove productive in the quest to find new markers of liver fibrosis....

  14. Pulmonary Fibrosis in BALB/c Mice Caused by Long-Term Instillation of Bleomycin

    OpenAIRE

    NAKAJIMA, Masamitsu

    1992-01-01

    It is well-known that bleomycin-induced pulmonary fibrosis is difficult to produce in BALB/c mice. To see whether bleomycin could induce pulmonary fibrosis in BALB/c mice, we repeatedly administered this drug through the airway for 10 consecutive days. Our experiment clearly showed that fibrosis can be induced, although it was rather mild, and also suggested that the bronchiolar and alveolar epithelia are the primary sites of injury. We believe this experimental model may be useful in studyin...

  15. Nephrogenic systemic fibrosis: epidemiology update

    DEFF Research Database (Denmark)

    Marckmann, P.

    2008-01-01

    Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated that gadoli......Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated...

  16. Lactate in cystic fibrosis sputum

    DEFF Research Database (Denmark)

    Bensel, Tobias; Stotz, Martin; Borneff-Lipp, Marianne

    2011-01-01

    Antibiotic therapy is thought to improve lung function in patients with cystic fibrosis (CF) by decreasing neutrophil-derived inflammation. We investigated the origin and clinical significance of lactate in the chronically inflamed CF lung. Methods Lactate was measured in sputa of 18 exacerbated...

  17. Meconium ileus in Cystic Fibrosis

    NARCIS (Netherlands)

    Sathe, Meghana; Houwen, Roderick

    2017-01-01

    Meconium ileus (MI) is often the first manifestation of cystic fibrosis (CF) and occurs in approximately 20% of patients diagnosed with CF. This article reviews the pathophysiology of MI and its clinical presentation. It focuses on the medical and surgical management emphasizing the importance of

  18. Cough in idiopathic pulmonary fibrosis

    NARCIS (Netherlands)

    M.J.G. Van Manen (Mirjam); S.S. Birring (Surinder S.); C. Vancheri (Carlo); V. Cottin (Vincent); Renzoni, E.A. (Elisabetta A.); Russell, A.-M. (Anne-Marie); M.S. Wijsenbeek (Marlies)

    2016-01-01

    textabstractMany patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF,

  19. Autophagy in idiopathic pulmonary fibrosis.

    Directory of Open Access Journals (Sweden)

    Avignat S Patel

    Full Text Available Autophagy is a basic cellular homeostatic process important to cell fate decisions under conditions of stress. Dysregulation of autophagy impacts numerous human diseases including cancer and chronic obstructive lung disease. This study investigates the role of autophagy in idiopathic pulmonary fibrosis.Human lung tissues from patients with IPF were analyzed for autophagy markers and modulating proteins using western blotting, confocal microscopy and transmission electron microscopy. To study the effects of TGF-β(1 on autophagy, human lung fibroblasts were monitored by fluorescence microscopy and western blotting. In vivo experiments were done using the bleomycin-induced fibrosis mouse model.Lung tissues from IPF patients demonstrate evidence of decreased autophagic activity as assessed by LC3, p62 protein expression and immunofluorescence, and numbers of autophagosomes. TGF-β(1 inhibits autophagy in fibroblasts in vitro at least in part via activation of mTORC1; expression of TIGAR is also increased in response to TGF-β(1. In the bleomycin model of pulmonary fibrosis, rapamycin treatment is antifibrotic, and rapamycin also decreases expression of á-smooth muscle actin and fibronectin by fibroblasts in vitro. Inhibition of key regulators of autophagy, LC3 and beclin-1, leads to the opposite effect on fibroblast expression of á-smooth muscle actin and fibronectin.Autophagy is not induced in pulmonary fibrosis despite activation of pathways known to promote autophagy. Impairment of autophagy by TGF-β(1 may represent a mechanism for the promotion of fibrogenesis in IPF.

  20. Nephrogenic systemic fibrosis: epidemiology update

    DEFF Research Database (Denmark)

    Marckmann, P.

    2008-01-01

    Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated that gadoli...

  1. Lung transplantation for cystic fibrosis

    NARCIS (Netherlands)

    Adler, Frederick R; Aurora, Paul; Barker, David H; Barr, Mark L; Blackwell, Laura S; Bosma, Otto H; Brown, Samuel; Cox, D R; Jensen, Judy L; Kurland, Geoffrey; Nossent, George D; Quittner, Alexandra L; Robinson, Walter M; Romero, Sandy L; Spencer, Helen; Sweet, Stuart C; van der Bij, Wim; Vermeulen, J; Verschuuren, Erik A M; Vrijlandt, Elianne J L E; Walsh, William; Woo, Marlyn S; Liou, Theodore G

    2009-01-01

    Lung transplantation is a complex, high-risk, potentially life-saving therapy for the end-stage lung disease of cystic fibrosis (CF). The decision to pursue transplantation involves comparing the likelihood of survival with and without transplantation as well as assessing the effect of wait-listing

  2. Panax notoginseng Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

    Directory of Open Access Journals (Sweden)

    Kuen-Daw Tsai

    2011-01-01

    Full Text Available Panax notoginseng (PN is a traditional Chinese herb experimentally proven to have anti-inflammatory effects, and it is used clinically for the treatment of atherosclerosis, cerebral infarction, and cerebral ischemia. This study aimed to determine the anti-inflammatory effects of PN against bleomycin-induced pulmonary fibrosis in mice. First, in an in vitro study, culture media containing lipopolysaccharide (LPS was used to stimulate macrophage cells (RAW 264.7 cell line. TNF-α and IL-6 levels were then determined before and after treatment with PN extract. In an animal model (C57BL/6 mice, a single dose of PN (0.5 mg/kg was administered orally on Day 2 or Day 7 postbleomycin treatment. The results showed that TNF-α and IL-6 levels increased in the culture media of LPS-stimulated macrophage cells, and this effect was significantly inhibited in a concentration-dependent manner by PN extract. Histopathologic examination revealed that PN administered on Day 7 postbleomycin treatment significantly decreased inflammatory cell infiltrates, fibrosis scores, and TNF-α, TGF-β, IL-1β, and IL-6 levels in bronchoalveolar lavage fluid when compared with PN given on Day 2 postbleomycin treatment. These results suggest that PN administered in the early fibrotic stage can attenuate pulmonary fibrosis in an animal model of idiopathic pulmonary fibrosis.

  3. Trabajo infantil : Análisis del trabajo infantil en el MERCOSUR

    OpenAIRE

    Portillo, Claudia Eugenia

    2004-01-01

    Hay en el mundo unos 250 millones de niños y niñas de entre 5 y 14 años que trabajan. Así lo han afirmado y probado diferentes organismos internacionales, entre ellos UNICEF y OIT, a más de los reconocimientos parciales efectuados por los diferentes Estados involucrados y las organizaciones no gubernamentales locales. Este es justamente el tema que se intentará analizar a lo largo de este trabajo, interdisciplinariamente desde la perspectiva de las relaciones internacionales y el Derecho Inte...

  4. [Therapeutic update in cystic fibrosis].

    Science.gov (United States)

    Durupt, S; Nove Josserand, R; Durieu, I

    2014-06-01

    We present the recent therapeutic advances in the cystic fibrosis care. It concerns improvements in symptomatic treatment with the development of dry powder inhaled antibiotics that improved quality of life, and innovative treatments namely the modulators of the cystic fibrosis transmembrane protein conductance regulator (CFTR), molecules which act specifically at the level of the defective mechanisms implied in the disease. The life expectancy of cystic fibrosis patients born after 2000, is estimated now to be about 50 years. This improvement of survival was obtained with the organization of the care within the specialized centers for cystic fibrosis (Centre de ressource et de compétences de la mucoviscidose) and remains still based on heavy symptomatic treatments. Dry powder inhaled antibiotics constitute a significant time saving for patients to whom all the care can achieve two hours daily. Since 2012, the modulators of CFTR, molecules allowing a pharmacological approach targeted according to the type of the mutations, allows a more specific approach of the disease. Ivacaftor (Kalydeco(®)) which potentialises the function of the CFTR protein expressed on the cellular surface is now available for patients with the G551D mutation. Lumacaftor is going to be tested in association with ivacaftor in patients with the F508del mutation, that is present in at least 75% of the patients. The ataluren which allows the production of a functional protein CFTR in patients with a no sense mutation is the third representing of this new therapeutic class. We presently have numerous symptomatic treatments for the cystic fibrosis care. The development of CFTR modulators, today available to a restricted number of patients treated with ivacaftor represents a very promising therapeutic avenue. It will represent probably the first step to a personalized treatment according to CFTR genotype. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by

  5. Efecto de un trabajo de técnica de desplazamiento y de un trabajo de cuestas sobre el desplazamiento en defensa y la capacidad de salto en voleibol

    Directory of Open Access Journals (Sweden)

    Vicente Ávila Gandía

    2010-09-01

    Full Text Available El objetivo del presente estudio fue comprobar el efecto de un trabajo de técnica de desplazamiento combinado o no con un trabajo de cuestas sobre la capacidad de desplazamiento general y específico y sobre la capacidad de alcance en jugadores de voleibol en periodo de formación. La muestra objeto de estudio fueron 36 jugadores de voleibol en formación (grupo A estuvo formado por 18 jugadores masculinos, y grupo B y C por nueve jugadoras cada uno. Se realizó un diseño cuasi-experimental intersujeto con una prueba pre, post, y re-test. La variable independiente fue el tipo de trabajo realizado para mejorar la capacidad de desplazamiento (nueve sesiones. Se distinguieron dos niveles de intervención: a realización de un trabajo de desplazamientos específicos (grupos A y B; y b realización de un trabajo de desplazamientos específicos y de un trabajo de fuerza en cuestas ascendentes (grupo C. Las variables dependientes fueron: la técnica y el tiempo de desplazamiento en bloqueo, y en defensa en campo, el tiempo en realización del test de 9-3-3-9, y la altura de alcance en un salto con y sin carrera de aproximación. El trabajo de técnica de desplazamientos mejora la calidad de ejecución de los desplazamientos específicos. En categoría masculina, el trabajo de técnica de desplazamiento mejora los tiempos de ejecución de los desplazamientos genéricos y de los desplazamientos específicos. En categoría femenina, el trabajo de técnica de desplazamiento no mejoró los tiempos de ejecución de los desplazamientos genéricos y de los desplazamientos específicos. En categoría femenina, el trabajo de técnica de desplazamiento realizado de forma conjunta con el trabajo de cuestas parece mejorar los tiempos de ejecución de los desplazamientos genéricos y de los desplazamientos específicos. El trabajo de técnica de desplazamiento con o sin el trabajo de cuestas no mejora la capacidad de alcance de los jugadores.

  6. Protein S is protective in pulmonary fibrosis.

    Science.gov (United States)

    Urawa, M; Kobayashi, T; D'Alessandro-Gabazza, C N; Fujimoto, H; Toda, M; Roeen, Z; Hinneh, J A; Yasuma, T; Takei, Y; Taguchi, O; Gabazza, E C

    2016-08-01

    Essentials Epithelial cell apoptosis is critical in the pathogenesis of idiopathic pulmonary fibrosis. Protein S, a circulating anticoagulant, inhibited apoptosis of lung epithelial cells. Overexpression of protein S in lung cells reduced bleomycin-induced pulmonary fibrosis. Intranasal therapy with exogenous protein S ameliorated bleomycin-induced pulmonary fibrosis. Background Pulmonary fibrosis is the terminal stage of interstitial lung diseases, some of them being incurable and of unknown etiology. Apoptosis plays a critical role in lung fibrogenesis. Protein S is a plasma anticoagulant with potent antiapoptotic activity. The role of protein S in pulmonary fibrosis is unknown. Objectives To evaluate the clinical relevance of protein S and its protective role in pulmonary fibrosis. Methods and Results The circulating level of protein S was measured in patients with pulmonary fibrosis and controls by the use of enzyme immunoassays. Pulmonary fibrosis was induced with bleomycin in transgenic mice overexpressing human protein S and wild-type mice, and exogenous protein S or vehicle was administered to wild-type mice; fibrosis was then compared in both models. Patients with pulmonary fibrosis had reduced circulating levels of protein S as compared with controls. Inflammatory changes, the levels of profibrotic cytokines, fibrosis score, hydroxyproline content in the lungs and oxygen desaturation were significantly reduced in protein S-transgenic mice as compared with wild-type mice. Wild-type mice treated with exogenous protein S showed significant decreases in the levels of inflammatory and profibrotic markers and fibrosis in the lungs as compared with untreated control mice. After bleomycin infusion, mice overexpressing human protein S showed significantly low caspase-3 activity, enhanced expression of antiapoptotic molecules and enhanced Akt and Axl kinase phosphorylation as compared with wild-type counterparts. Protein S also inhibited apoptosis of alveolar

  7. Relationship between thickness of fibrosis and epithelial dysplasia in oral submucous fibrosis.

    Science.gov (United States)

    Jayasooriya, Primali Rukmal; Nadeeka Jayasinghe, Kadawatha Arachchige; Mudiyanselage Tilakaratne, Wanninayaka

    2011-08-01

      Although oral submucous fibrosis is characterized by fibrosis of the subepithelial connective tissue, the overlying epithelial changes contribute to malignant transformation. Therefore, the aim of the study was to evaluate the relationship between thickness of fibrosis and epithelial changes in oral submucous fibrosis.   The relationship between thickness of fibrosis and presence or absence of epithelial dysplasia was evaluated in 107 biopsies containing histopathologically-confirmed oral submucous fibrosis. The results were analyzed using Student's t-test or χ(2) -test.   Fifty-seven percent (61/107) of oral submucous fibrosis lesions showed a non-dysplastic overlying epithelium, while 43% (46/107) showed varying degrees of epithelial dysplasia. The mean thickness of fibrosis of non-dysplastic lesions was 0.91±0.41 mm (mean ± standard deviation) and ranged from 0.25 to 1.9 mm. However, the mean thickness of fibrosis of dysplastic lesions was 1.17 ± 0.52 mm and ranged from 0.48 to 3 mm. The results revealed a significant increase in the incidence of epithelial dysplasia as the thickness of fibrosis increased (P = 0.004). As such, the lesions that showed increased fibrosis were more likely to present with epithelial dysplasia.   The advancement of fibrosis increases the risk of development of epithelial dysplasia in oral submucous fibrosis. © 2011 Blackwell Publishing Asia Pty Ltd.

  8. La intensificación del trabajo en España (2007-2011: trabajo en equipo y flexibilidad

    Directory of Open Access Journals (Sweden)

    Francisco Javier Pinilla García

    2017-01-01

    Full Text Available En este artículo analizamos la relación entre el proceso de intensificación del trabajo y la flexibilidad organizacional. Específicamente, nos centramos en el trabajo en equipo, como estrategia organizacional considerada emblemática de las organizaciones flexibles y eficientes. Analizamos la relación entre trabajo en equipo, intensidad y estrés, explotando los datos de las Encuestas Nacionales de Condiciones de Trabajo. A partir de los resultados obtenidos, proponemos incorporar el análisis de la intensidad del trabajo en el ámbito del diálogo social y en la prevención de riesgos laborales.

  9. MRI in mucoviscidosis (cystic fibrosis)

    International Nuclear Information System (INIS)

    Eichinger, M.; Puderbach, M.; Kauczor, H.-U.; Heussel, C.-P.

    2006-01-01

    Cystic fibrosis (CF) is a multi-systemic disease with major impact on the lungs. Pulmonary manifestation is crucial for the prognosis and life expectancy of patients. Imaging modalities and lung function tests reflect the pulmonary status in these patients. The standard imaging modality for diagnosis and follow-up of pulmonary changes is chest x-ray. The gold standard for the detection of parenchymal lung changes remains high resolution computed tomography (HRCT), but this is not used routinely for CF-patients due to radiation exposure. Magnetic resonance imaging (MRI) used to be of no importance in monitoring cystic fibrosis lung disease, as shown in studies from the 1980s and early 1990s. The continuing improvement of MRI techniques, however, has allowed for an adequate application of this non-radiation method in diagnosing the major pulmonary findings in CF, in addition to the assessment of lung function. (orig.) [de

  10. Fibrosis endomiocárdica

    Directory of Open Access Journals (Sweden)

    María Juliana Rodríguez-González

    2017-07-01

    Una de las formas más comunes de miocardiopatía restrictiva es la fibrosis endomiocárdica la cual es endémica en algunas zonas tropicales especialmente en África (países de bajos ingresos, pero en nuestro medio hay pocos reportes de aparición. Su etiología es desconocida, aunque existen diversos mecanismos que han sido involucrados en su fisiopatología. Su diagnóstico se basa en estudios imagenológicos (ecocardiograma transtorácico y resonancia magnética nuclear cardíaca. El pronóstico es muy pobre, y usualmente se diagnostica en etapas muy avanzadas de la enfermedad. Se describe el caso de una paciente femenina, adulta media, que debutó con cardiopatía restrictiva, cuyo diagnóstico final fue fibrosis endomiocárdica.

  11. A case of cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Maria Alice Monti

    2009-09-01

    Full Text Available As the expected survival improves for patients with cystic fibrosis (CF, there is a growing population of adults with this disease. We describe a case of a 33-year-old woman with CF presenting with recurrent pancreatitis, malnutrition, borderline sweat test and respiratory diseases. The case report underlines the importance of diagnosis and management of CF in adults, and the important role played by the Family Physician in developing an adult care program.

  12. Idiopathic pulmonary fibrosis: treatment update.

    LENUS (Irish Health Repository)

    O'Connell, Oisin J

    2011-11-01

    Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. Despite multiple recent clinical trials, there is no strong evidence supporting a survival advantage for any agent in the management of patients with IPF. The limited effectiveness of current treatment regimes has led to a search for novel therapies including antifibrotic strategies. This article reviews the evidence supporting the treatments currently used in the management of IPF.

  13. Recommendations for quality improvement in genetic testing for cystic fibrosis European Concerted Action on Cystic Fibrosis

    NARCIS (Netherlands)

    Dequeker, E; Cuppens, H; Dodge, J; Estivill, [No Value; Goossens, M; Pignatti, PF; Scheffer, H; Schwartz, M; Schwarz, M; Tummler, B; Cassiman, JJ

    These recommendations for quality improvement of cystic fibrosis genetic diagnostic testing provide general guidelines for the molecular genetic testing of cystic fibrosis in patients/individuals. General strategies for testing as well as guidelines for laboratory procedures, internal and external

  14. Oral submucous fibrosis: an update

    Directory of Open Access Journals (Sweden)

    Wollina U

    2015-04-01

    Full Text Available Uwe Wollina,1 Shyam B Verma,2 Fareedi Mukram Ali,3 Kishor Patil4 1Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; 2Nirvana Skin Clinic, Vadodara, Gujarat, India; 3Departments of Oral and Maxillofacial Surgery, SMBT Dental College, Sangamner, Maharashtra, India; 4Departments of Oral Pathology and Microbiology, SMBT Dental College, Sangamner, Maharashtra, India Abstract: Oral submucous fibrosis (OSF is a premalignant condition caused by betel chewing. It is very common in Southeast Asia but has started to spread to Europe and North America. OSF can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. OSF is a diagnosis based on clinical symptoms and confirmation by histopathology. Hypovascularity leading to blanching of the oral mucosa, staining of teeth and gingiva, and trismus are major symptoms. Major constituents of betel quid are arecoline from betel nuts and copper, which are responsible for fibroblast dysfunction and fibrosis. A variety of extracellular and intracellular signaling pathways might be involved. Treatment of OSF is difficult, as not many large, randomized controlled trials have been conducted. The principal actions of drug therapy include antifibrotic, anti-inflammatory, and antioxygen radical mechanisms. Potential new drugs are on the horizon. Surgery may be necessary in advanced cases of trismus. Prevention is most important, as no healing can be achieved with available treatments. Keywords: betel nut, betel quid, oral disease, squamous cell carcinoma, tobacco, fibrosis

  15. Pathogenic mechanism in lung fibrosis

    International Nuclear Information System (INIS)

    Witschi, H.; Haschek, W.M.; Meyer, K.R.; Ullrich, R.L.; Dalbey, W.E.

    1979-01-01

    The purpose of the study was to examine whether an interaction between two agents causing alveolar epithelial damage would produce lung fibrosis. In mouse lung, intraperitoneal injection of the antioxidant butylated hydroxytoluene causes diffuse alveolar type I cell necrosis, followed by proliferation of type II alveolar cells. In animals exposed to 70% O 2 or 100-200 rad x rays during the phase of type II cell proliferation following BHT, diffuse interstitial lung fibrosis developed within 2 weeks. Quantitative analysis of the lungs for hydroxyproline showed that the interaction between BHT and O 2 or x rays was synergistic. If exposure to O 2 or x rays was delayed until epithelial recovery was complete, no fibrosis was seen. Abnormally high levels of lung collagen persisted up to 6 months after one single treatment with BHT and 100 rad x rays. A commonly seen form of chronic lung damage may thus be caused by an acute interaction between a bloodborne agent which damages the alveolar cell and a toxic inhalant or x rays, provided a critically ordered sequence of exposure is observed

  16. Mast Cells: Key Contributors to Cardiac Fibrosis

    Directory of Open Access Journals (Sweden)

    Scott P. Levick

    2018-01-01

    Full Text Available Historically, increased numbers of mast cells have been associated with fibrosis in numerous cardiac pathologies, implicating mast cells in the development of cardiac fibrosis. Subsequently, several approaches have been utilised to demonstrate a causal role for mast cells in animal models of cardiac fibrosis including mast cell stabilising compounds, rodents deficient in mast cells, and inhibition of the actions of mast cell-specific proteases such as chymase and tryptase. Whilst most evidence supports a pro-fibrotic role for mast cells, there is evidence that in some settings these cells can oppose fibrosis. A major gap in our current understanding of cardiac mast cell function is identification of the stimuli that activate these cells causing them to promote a pro-fibrotic environment. This review will present the evidence linking mast cells to cardiac fibrosis, as well as discuss the major questions that remain in understanding how mast cells contribute to cardiac fibrosis.

  17. Mujeres y mercado de trabajo del turismo alternativo en Veracruz

    Directory of Open Access Journals (Sweden)

    Isis Arlene Díaz-Carrión

    2013-01-01

    Full Text Available Resultado de su compromiso con una sustentabilidad social, el turismo alternativo es considerado una actividad para potenciar cambios en la tradicional división del trabajo. En esta investigación cualitativa se revisa la participación de las mujeres en el turismo alternativo del estado de Veracruz y se visibilizan segregaciones ocupacionales y simultaneidad en la realización de trabajo productivo- reproductivo y de cuidados. El enfoque de género se muestra como una herramienta potencial para observar el trabajo productivo de las mujeres y promover el acceso al espacio público y sus recursos.

  18. Trabajo colaborativo, espacio digital y e-learning

    OpenAIRE

    Redondo Casado, Félix

    2009-01-01

    El EEES exige a los profesores el trabajo con las nuevas tecnologías de la información y la comunicación, que posibilitan la informática y las redes. La hipótesis principal del estudio es que el trabajo colaborativo se configura como un procedimiento atractivo y fructífero para crear el conocimiento entre profesor y alumnos. El siguiente trabajo, tras una introducción a este fenómeno hace una conceptualización del significado de lo colaborativo, así como de espacio digital (preferible a espac...

  19. Trabajos en espacios confinados. Riesgos y medidas preventivas

    OpenAIRE

    Fernández, Sergio

    2012-01-01

    La ejecución de trabajos en espacios confinados resulta una necesidad en diversos sectores como por ejemplo en la industria química, redes de alcantarillado, construcción de barcos, en pozos,… con el fin desarrollar diversas tareas como limpiezas, inspecciones interiores, trabajos de pintura, reparaciones varias,… lo que implica la implantación de medidas especiales y rigurosas a planificar y llevar a cabo. Los riesgos que presentan la ejecución de estos trabajos en espacios confinados ...

  20. Inhaled corticosteroids for cystic fibrosis.

    Science.gov (United States)

    Balfour-Lynn, Ian M; Welch, Karen

    2016-08-23

    Reduction of lung inflammation is one of the goals of cystic fibrosis therapy. Inhaled corticosteroids are often used to treat children and adults with cystic fibrosis. The rationale for this is their potential to reduce lung damage arising from inflammation, as well as their effect on symptomatic wheezing. It is important to establish the current level of evidence for the risks and benefits of inhaled corticosteroids, especially in the light of their known adverse effects on growth. This is an update of a previously published review. To assess the effectiveness of taking regular inhaled corticosteroids, compared to not taking them, in children and adults with cystic fibrosis. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register, comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. We requested information from pharmaceutical companies manufacturing inhaled corticosteroids and authors of identified trials.Date of most recent search of the Group's Trials Register: 15 August 2016. Randomised or quasi-randomised trials, published and unpublished, comparing inhaled corticosteroids to placebo or standard treatment in individuals with cystic fibrosis. Two independent authors assessed methodological quality and risk of bias in trials using established criteria and extracted data using standard pro formas. The searches identified 34 citations, of which 26 (representing 13 trials) were eligible for inclusion. These 13 trials reported the use of inhaled corticosteroids in 506 people with cystic fibrosis aged between six and 55 years. One was a withdrawal trial in individuals who were already taking inhaled corticosteroids. Methodological quality and risk of bias were difficult to assess from published information. Many of the risk of bias judgements were unclear due to a lack of available information. Only two trials specified how

  1. El trabajo penitenciario militar español

    OpenAIRE

    Serrano Patiño, Juan Victorio

    2015-01-01

    En el sistema penitenciario militar, el trabajo penitenciario presenta unas características distintas del sistema penitenciario ordinario, dada la especialidad castrense. En este artículo se analizará todo esto.

  2. Trabajo femenino, Empoderamiento y Bienestar de la Familia

    OpenAIRE

    Casique, Irene

    2004-01-01

    El objetivo que nos planteamos en este trabajo es examinar los posibles efectos que tanto el trabajo extra-doméstico femenino como el empoderamiento de la mujer puedan tener sobre dos aspectos particulares del bienestar familiar en México: la erradicación de la violencia hacia la mujer y la mayor participación de los hombres en el cuidado y crianza de los hijos.

  3. EVALUACIÓN ERGONÓMICA DEL PUESTO DE TRABAJO

    OpenAIRE

    Vázquez-Barandica, Mikel

    2012-01-01

    El objeto de la Evaluación Psicosocial es estimar y valorar la magnitud de aquellos riesgos asociados a las condiciones psicosociales de trabajo, existentes en el centro de trabajo de Sarriguren, todo ello con la finalidad última de aportar a la empresa la información adecuada para tomar las decisiones apropiadas sobre la necesidad de adoptar nuevas medidas y planificar adecuadamente la actividad preventiva

  4. Salud y Seguridad del Trabajo en Portugal: apuntes diversos

    Directory of Open Access Journals (Sweden)

    António de Sousa Uva

    Full Text Available El autor aborda algunos aspectos relativos a la Salud y Seguridad del Trabajo (SST en Portugal llamando la atención para, esencialmente, intentar sostener la tesis de que, desde mediados de la década de los 90, se observaron importantes avances en la mejoría de las condiciones del trabajo en la perspectiva de la SST, aunque se mantuvieron algunos problemas en la práctica concreta de las normativas legales. Incluso con estas mejoras, las tasas de frecuencia de accidentes de trabajo y de enfermedades profesionales en Portugal todavía se mantienen muy elevadas necesitando, por tanto, estrategias más "agresivas" para concienciar la sociedad portuguesa en torno a las políticas públicas de SST efectivamente promotoras de prevención de riesgos profesionales y de la promoción de la salud de quien trabaja. Es por tanto indispensable que la protección de la salud y de la seguridad de los trabajadores en los puestos de trabajo sea encarada como un conjunto de actividades de indiscutible utilidad para todos los representantes del mundo del trabajo e que la agenda política pase a valorizar, aún más, la promoción de espacios de trabajo saludables y seguros, con la consecuente valorización de las variables individuales en la estrategia nacional de salud y seguridad.

  5. LOS ROLES NO LABORALES Y EL ESTRES EN EL TRABAJO

    Directory of Open Access Journals (Sweden)

    Juan Guerrero

    2003-07-01

    Full Text Available Este análisis se ocupa de dimensiones esenciales de las personas vinculadas al mundo del trabajo: el “momento de trabajo†y el “momento de no-trabajoâ€. Se cotejan relaciones y procesos invariablemente presentes en el diario vivir de hombres y mujeres, pero que afectan su bienestar y desempeño ocupacional de manera distinta. Se trata de aspectos que convergen y se potencian para dar lugar a variados perfiles de vida laboral y extralaboral, a diferentes perfiles de salud y productividad. Estos son entre otros: los conocimientos y habilidades del individuo, sus condiciones de genero, sus expectativas ocupacionales, su estilo de vida, sus valores y patrones de crianza, su vulnerabilidad al estrés, sus estrategias de afrontamiento, las oportunidades de empleo, la diversidad de roles, el tiempo disponible para atenderlos, la naturaleza y disponibilidad de apoyo social. El concepto que orienta todo el análisis es el de “spillover†trabajo-familia, que corresponde a la permanente e inevitable “contaminación psicológica†de las circunstancias del trabajo sobre la vida familiar y viceversa. Se trata de un proceso connatural a la existencia de hombres y mujeres de la sociedad industrial y que invariablemente está presente para enriquecer o empobrecer el desempeño humano en, dentro o fuera del trabajo.

  6. El trabajo docente universitario: significados, sujetos e historia

    Directory of Open Access Journals (Sweden)

    María del R. Badano

    2004-01-01

    Full Text Available En este artículo se presentan algunos aspectos de la investigación realizada en el marco del Proyecto “El trabajo docente universitario: significados para los sujetos que lo realizan. Descripción y diagnóstico de los docentes de la Universidad Nacional de Entre Ríos”, ejecutado en la Facultad de Trabajo Social durante el período 1998/2001. Docentes del Area Pedagógica de dicha unidad académica llevaron adelante esta investigación, que asume una metodología de trabajo cualitativa -con utilización de estrategias cuantitativas y cualitativas según los diferentes momentos- y que incluyó actividades de retroalimentación y transferencia a través de las cuales se construyeron descripciones que dieron cuenta de la particularidad del trabajo docente universitario en la UNER. El trabajo de campo constituyó la etapa central de la investigación, y junto con el análisis, posibilitó las elaboraciones presentadas. Los aspectos expuestos aquí, se relacionan con la historia del objeto, la información cuantitativa sobre los docentes y los significados que habitualmente se asignan al trabajo docente en la universidad.

  7. The Sociology and Entrenchment. A Cystic Fibrosis Test for Everyone?

    DEFF Research Database (Denmark)

    Koch, Lene; Stemerding, Dirk

    1994-01-01

    Socialmedicine, genetic screening, cystic fibrosis, ethics, political regulation, sociology of technology......Socialmedicine, genetic screening, cystic fibrosis, ethics, political regulation, sociology of technology...

  8. Daniel Solano: "Me matan si no trabajo, y si trabajo me matan"

    Directory of Open Access Journals (Sweden)

    Jessica Visotsky

    2015-01-01

    Full Text Available Existe una creencia en el noroeste argentino que es la Leyenda del Familiar, esta leyenda que al parecer surgiría ligada al desarrollo industrial, nace y se desarrolla ligada a la instalación de los ingenios azucareros a fines del siglo XIX y principios del XX. En los mismos se llevó a cabo la explotación de miles y miles de trabajadores bajo condiciones inhumanas de trabajo y salarios miserables. El familiar era el perro del diablo o el diablo mismo, podía también adoptar formas de viborón, toro, burro, por lo general era un perro, negro, desprendía llamaradas de fuego por los ojos, tenía una fuerza descomunal en sus garras, con quién el patrón del ingenio o capataz había hecho un pacto: que saciaría su hambre con la entrega de un obrero por año, y éste le aseguraría prosperidad. En distintas situaciones un obrero podía encontrar la muerte, sea por accidentes, sea cayendo a una caldera, atrapado en una cinta trituradora de la caña, o si un trabajador desaparecía se decía que era obra “del familiar”.

  9. Alveolar type II cell transplantation restores pulmonary surfactant protein levels in lung fibrosis.

    Science.gov (United States)

    Guillamat-Prats, Raquel; Gay-Jordi, Gemma; Xaubet, Antoni; Peinado, Victor I; Serrano-Mollar, Anna

    2014-07-01

    Alveolar Type II cell transplantation has been proposed as a cell therapy for the treatment of idiopathic pulmonary fibrosis. Its long-term benefits include repair of lung fibrosis, but its success partly depends on the restoration of lung homeostasis. Our aim was to evaluate surfactant protein restoration after alveolar Type II cell transplantation in an experimental model of bleomycin-induced lung fibrosis in rats. Lung fibrosis was induced by intratracheal instillation of bleomycin. Alveolar Type II cells were obtained from healthy animals and transplanted 14 days after bleomycin was administered. Furthermore, one group transplanted with alveolar macrophages and another group treated with surfactant were established to evaluate the specificity of the alveolar Type II cell transplantation. The animals were euthanized at 21 days after bleomycin instillation. Lung fibrosis was confirmed by a histologic study and an evaluation of the hydroxyproline content. Changes in surfactant proteins were evaluated by mRNA expression, Western blot and immunofluorescence studies. The group with alveolar Type II cell transplantation was the only one to show a reduction in the degree of lung fibrosis and a complete recovery to normal levels of surfactant proteins. One of the mechanisms involved in the beneficial effect of alveolar Type II cell transplantation is restoration of lung surfactant protein levels, which is required for proper respiratory function. Copyright © 2014 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.

  10. Pulmonary complications of cystic fibrosis

    International Nuclear Information System (INIS)

    Ng, M.Y.; Flight, W.; Smith, E.

    2014-01-01

    The life expectancy of patients with cystic fibrosis (CF) has steadily increased over recent decades with a corresponding increase in the frequency of complications of the disease. Radiologists are increasingly involved with managing and identifying the pulmonary complications of CF. This article reviews the common manifestations of CF lung disease as well as updating radiologists with a number of less well-known complications of the condition. Early and accurate detection of the pulmonary effects of CF are increasingly important to prevent irreversible lung damage and give patients the greatest possibility of benefiting from the new therapies becoming available, which correct the underlying defect causing CF

  11. Liver manifestations of cystic fibrosis

    International Nuclear Information System (INIS)

    Akata, Deniz; Akhan, Okan

    2007-01-01

    Chronic liver disease is one of the major complications of cystic fibrosis (CF). Significant liver disease is seen in 13-25% of children with CF. Improved life expectancy and prolonged follow-up have favored better characterization of the hepatic manifestations of CF and allowed direct observation of an increasing number of liver-related events. Liver disease typically develops in the first decade of life, with the incidence dropping rapidly after the age of 10 years. The wide spectrum of liver disease ranging from asymptomatic gallbladder abnormalities to biliary cirrhosis will be reviewed in this article

  12. Rectal prolapse and cystic fibrosis.

    Science.gov (United States)

    El-Chammas, Khalil I; Rumman, Nisreen; Goh, Vi Lier; Quintero, Diana; Goday, Praveen S

    2015-01-01

    Screening for cystic fibrosis (CF) is suggested in patients with rectal prolapse (RP). Little is known about the association between CF and RP in the era of newborn screening for CF. Our retrospective review showed that 3.6% of patients with RP had CF, and 3.5% of patients with CF had RP. No demographic or clinical factors appear to predict the likelihood of RP in patients with CF. Sweat chloride testing for patients with RP has a low yield in the era of newborn screening but may still need to be considered in children with RP to avoid missing the rare child with CF.

  13. Outcome in cystic fibrosis liver disease.

    LENUS (Irish Health Repository)

    Rowland, Marion

    2011-01-01

    Evidence suggests that cystic fibrosis liver disease (CFLD) does not affect mortality or morbidity in patients with cystic fibrosis (CF). The importance of gender and age in outcome in CF makes selection of an appropriate comparison group central to the interpretation of any differences in mortality and morbidity in patients with CFLD.

  14. Laparoscopic cholecystectomy in adult cystic fibrosis.

    LENUS (Irish Health Repository)

    McGrath, D S

    2012-02-03

    Two female patients with Cystic Fibrosis, attending the Adult Regional Cystic Fibrosis centre at the Cork University Hospital, were investigated for upper abdominal pain and found to have gallstones at ultrasonography. Laparoscopic cholecystectomy was performed successfully and, without complication, in both patients.

  15. Self-management education for cystic fibrosis.

    LENUS (Irish Health Repository)

    Savage, Eileen

    2011-01-01

    Self-management education may help patients with cystic fibrosis and their families to choose, monitor and adjust treatment requirements for their illness, and also to manage the effects of illness on their lives. Although self-management education interventions have been developed for cystic fibrosis, no previous systematic review of the evidence of effectiveness of these interventions has been conducted.

  16. European Cystic Fibrosis Society Standards of Care

    DEFF Research Database (Denmark)

    Stern, Martin; Bertrand, Dominique Pougheon; Bignamini, Elisabetta

    2014-01-01

    Since the earliest days of cystic fibrosis (CF) treatment, patient data have been recorded and reviewed in order to identify the factors that lead to more favourable outcomes. Large data repositories, such as the US Cystic Fibrosis Registry, which was established in the 1960s, enabled successful...

  17. Unusual Presentation Of Idiopathic Retroperitoneal Fibrosis: Case ...

    African Journals Online (AJOL)

    Idiopathic retroperitoneal fibrosis (IRF) is an uncommon entity described as progressive proliferation of connective tissues leading to a fibrous plaque-like lesions that encases the aorta and inferior vena cava inferior to the level of the renal arteries. Mass forming retroperitoneal fibrosis is rare. We present a rare case of a ...

  18. Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model.

    Science.gov (United States)

    van Koppen, Arianne; Verschuren, Lars; van den Hoek, Anita M; Verheij, Joanne; Morrison, Martine C; Li, Kelvin; Nagabukuro, Hiroshi; Costessi, Adalberto; Caspers, Martien P M; van den Broek, Tim J; Sagartz, John; Kluft, Cornelis; Beysen, Carine; Emson, Claire; van Gool, Alain J; Goldschmeding, Roel; Stoop, Reinout; Bobeldijk-Pastorova, Ivana; Turner, Scott M; Hanauer, Guido; Hanemaaijer, Roeland

    2018-01-01

    The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynamics of key molecular processes involved in NASH and to rank early markers for hepatic fibrosis. A time-course study in low-density lipoprotein-receptor knockout. Leiden mice on a high-fat diet was performed to identify the temporal dynamics of key processes contributing to NASH and fibrosis. An integrative systems biology approach was used to elucidate candidate markers linked to the active fibrosis process by combining transcriptomics, dynamic proteomics, and histopathology. The translational value of these findings were confirmed using human NASH data sets. High-fat-diet feeding resulted in obesity, hyperlipidemia, insulin resistance, and NASH with fibrosis in a time-dependent manner. Temporal dynamics of key molecular processes involved in the development of NASH were identified, including lipid metabolism, inflammation, oxidative stress, and fibrosis. A data-integrative approach enabled identification of the active fibrotic process preceding histopathologic detection using a novel molecular fibrosis signature. Human studies were used to identify overlap of genes and processes and to perform a network biology-based prioritization to rank top candidate markers representing the early manifestation of fibrosis. An early predictive molecular signature was identified that marked the active profibrotic process before histopathologic fibrosis becomes manifest. Early detection of the onset of NASH and fibrosis enables identification of novel blood-based biomarkers to stratify patients at risk, development of new therapeutics, and help shorten (pre)clinical experimental time frames.

  19. Gene therapy for cystic fibrosis.

    Science.gov (United States)

    Mueller, Christian; Flotte, Terence R

    2008-12-01

    Cystic Fibrosis (CF) is an autosomal recessive disorder due to mutations in the CF transmembrane conductance regulator (CFTR) gene that lead to defective ion transport in the conducting pulmonary airways and exocrine glands. Through a process that is not fully understood, CFTR defects predispose affected patients to chronic endobronchial infections with organisms such as Pseudomonas aeruginosa and Staphylococcus aureus. Following the discovery of the CFTR gene in 1989, CF became one of the primary targets for gene therapy research. Early enthusiasm surrounded the new field of gene therapy during most of the 1990s and it led academics and clinicians on a big effort to apply gene therapy for cystic fibrosis. Clinical studies have been pursued using recombinant adenovirus, recombinant adeno-associated virus, cationic liposomes, and cationic polymer vectors. Although to this date no dramatic therapeutic benefits have been observed, a lot of information has been gained from the pre-clinical and clinical studies that were performed. This learning curve has led to the optimization of vector technology and an appreciation of immune and mechanical barriers that have to be overcome for successful delivery.

  20. MR evaluation of retroperitoneal fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Kamper, L.; Scharwaechter, C.; Haage, P.; Piroth, W. [HELIOS-KLINIK Wuppertal - Klinikum der Privaten Univ. Witten/Herdecke (Germany). Klinik fuer Diagnostische und Interventionelle Radiologie; Brandt, A.S.; Kukuk, S.; Roth, S. [HELIOS-KLINIK Wuppertal - Klinikum der Privaten Univ. Witten/Herdecke (Germany). Klinik fuer Urologie

    2011-08-15

    Purpose: Retroperitoneal fibrosis (RPF) is a rare fibrosing process. The relation of contrast enhancement within the fibrosis and the psoas muscle was suggested for the evaluation of disease activity and response to treatment, but no standardized method for the quantification of the disease activity is currently available. We introduce an MR parameter for the evaluation of RPF. Materials and Methods: 29 patients with untreated idiopathic RPF were examined before medical therapy and after three months of treatment. MR analyses included quotients of T 1 and T 2-signal intensities between the RPF and the psoas muscle. Furthermore, we examined the dynamic contrast enhancement of the fibrous tissue. The respective data were compared with the extent of the RPF after 3 months. Results: In the follow-up examinations we observed a significant regression in 37.9 % (n = 11) of cases, a mild regression in 48.3 % (n = 14) and a stable extent in 13.8 % (n = 4). Patients with a significantly reduced extent showed the highest mean values for the applied MR quotients in the initial examination. The lowest mean values for the respective parameters were found for the group with a stable extent. Only dynamic enhancement quotients showed statistically significant differences (p = 0.011) between the groups of response. Conclusion: We observed a significant reduction in the fibrous tissue after pharmacological treatment in patients with an elevated dynamic enhancement quotient in the initial examination. (orig.)

  1. Postinjection Muscle Fibrosis from Lupron

    Directory of Open Access Journals (Sweden)

    Erica Everest

    2015-01-01

    Full Text Available We describe the case of a 6.5-year-old girl with central precocious puberty (CPP, which signifies the onset of secondary sexual characteristics before the age of eight in females and the age of nine in males as a result of stimulation of the hypothalamic-pituitary-gonadal axis. Her case is likely related to her adoption, as children who are adopted internationally have much higher rates of CPP. She had left breast development at Tanner Stage 2, adult body odor, and mildly advanced bone age. In order to halt puberty and maximize adult height, she was prescribed a gonadotropin releasing hormone analog, the first line treatment for CPP. She was administered Lupron (leuprolide acetate Depot-Ped (3 months intramuscularly. After her second injection, she developed swelling and muscle pain at the injection site on her right thigh. She also reported an impaired ability to walk. She was diagnosed with muscle fibrosis. This is the first reported case of muscle fibrosis resulting from Lupron injection.

  2. Parenting adolescents with cystic fibrosis

    DEFF Research Database (Denmark)

    Bregnballe, Vibeke; Schiøtz, Peter Oluf; Lomborg, Kirsten

    2011-01-01

    Background: When suffering from cystic fibrosis (CF), a number of problems may arise during adolescence; for example, poor adherence. The problems may be attributed to the adolescent being insufficiently prepared for adult life. Research on different ways of parenting adolescents with CF and the ......Background: When suffering from cystic fibrosis (CF), a number of problems may arise during adolescence; for example, poor adherence. The problems may be attributed to the adolescent being insufficiently prepared for adult life. Research on different ways of parenting adolescents with CF...... and the influence of different parenting styles on the adolescents’ adherence to treatment is still limited. Aim: The aim of this study was to identify the types of parental support that adolescents and young adults with CF want and find helpful in terms of preparing them for adult life. Methods: Sixteen Danish...... was conducted. Results: The adolescents and young adults wanted their parents educated about the adolescent experience. They wanted their parents to learn a pedagogical parenting style, to learn to trust them, and to learn to gradually transfer responsibility for their medical treatment. Additionally...

  3. Las trabajadoras de la salud: vida, trabajo y trastornos mentales

    Directory of Open Access Journals (Sweden)

    Noriega Mariano

    2004-01-01

    Full Text Available Se estudió la relación entre condiciones de vida, trabajo y trastornos mentales en trabajadoras de la salud del Instituto Mexicano del Seguro Social (IMSS. La población se integró por médicas, enfermeras, personal de laboratorio y asistentes médicas (n = 170. La información principal se obtuvo de una encuesta, validada en población trabajadora mexicana. Se encontró que los trastornos mentales están relacionados con todos los ámbitos de la vida de las mujeres. En relación con el ámbito doméstico, se muestra que las mujeres con mayor morbilidad mental son: las que son madres; las que tienen un mayor número de hijos; aquéllas que no cuentan con ayuda para el trabajo doméstico; y las que tienen pareja. En relación con el trabajo asalariado, la morbilidad mental se encontró asociada con la duración de la jornada, el ausentismo y la falta de contenido del trabajo. El desarrollo de habilidades, la satisfacción y la creatividad fueron aspectos "protectores" o preventivos de trastornos mentales y de fatiga. Los principales riesgos y exigencias que actuaron como causantes de estrés fueron: el calor, el ruido, el esfuerzo físico, las posiciones forzadas y el trabajo intenso y repetitivo.

  4. Trabajo no clásico y flexibilidad

    Directory of Open Access Journals (Sweden)

    Enrique de la Garza Toledo

    Full Text Available En este ensayo presentaremos el concepto de trabajo no clásico (De la Garza, 2010, como un intento de dar cuenta no solo de las diferencias en los tipos de trabajo, sino de dimensiones amplias de lo laboral incluidas en forma parcial en otras teorizaciones (Thompson, 1983. Buscaremos precisar el concepto y su alcance, así como las relaciones con las actividades de servicios, que se han vuelto cada vez más importantes en las economías modernas, sin olvidar su peso en las menos desarrolladas. Entraremos a recapitular sobre el concepto clásico de flexibilidad (Durand, 2004 y la ampliación que sería pertinente al incluir trabajos no clásicos. En particular incluiremos una forma de flexibilización que probablemente se esté convirtiendo en dominante en el capitalismo luego de la última gran crisis económica, la subcontratación (Moncada y Monsalvo, 2000 y sus vínculos con el trabajo no clásico. Finalmente, discutiremos las tesis de la fragmentación de identidades (Sennet y Coob, 1972 y la servidumbre voluntaria (Durand, 2006 al calor del enfoque mencionado de trabajo no cásico, para culminar con consideraciones acerca de la posibilidad de constitución de sujetos laborales en estas condiciones.

  5. Tumoral fibrosis effect on the radiation absorbed dose of 177Lu–Tyr3-octreotate and 177Lu–Tyr3-octreotate conjugated to gold nanoparticles

    International Nuclear Information System (INIS)

    Azorín-Vega, E.P.; Zambrano-Ramírez, O.D.; Rojas-Calderón, E.L.; Ocampo-García, B.E.; Ferro-Flores, G.

    2015-01-01

    The aim of this work was to evaluate the tumoral fibrosis effect on the radiation absorbed dose of the radiopharmaceuticals 177 Lu–Tyr 3 -octreotate (monomeric) and 177 Lu–Tyr 3 -octreotate–gold nanoparticles (multimeric) using an experimental HeLa cells tumoral model and the Monte Carlo PENELOPE code. Experimental and computer micro-environment models with or without fibrosis were constructed. Results showed that fibrosis increases up to 33% the tumor radiation absorbed dose, although the major effect on the dose was produced by the type of radiopharmaceutical (112 Gy-multimeric vs. 43 Gy-monomeric). - Highlights: • Fibrosis increases the radiation absorbed dose to the tumor. • Fibrosis increases the radiopharmaceutical residence time in the tumor. • The multimeric nature of the radiopharmaceuticals enhances the radiopharmaceutical retention

  6. El mercado de trabajo norteamericano y los trabajadores mexicanos

    Directory of Open Access Journals (Sweden)

    Fernando Mercado N.

    1983-05-01

    Full Text Available Este trabajo aborda la problemática de los trabajadores indocumentados mexicanos y su inserción en el mercado de trabajo norteamericano. Se revisan algunos de los juicios y supuestos emitidos sobre este tema y se cuestiona la manera en que se han venido planteando. Como inicio se presentan algunos elementos del mercado de trabajo estadounidense que son necesarios para formalizar el nivel del debate y empezar a apreciar la complejidad de esta problemática. La intención no es negar que existe una situación irregular causada por la presencia de los trabajadores mexicanos en Estados Unidos, ni transferir responsabilidades, sino sugerir que la situación es más compleja de lo que se piensa y que, antes de proponer soluciones, es preciso conocer la verdadera dimensión del fenómeno.

  7. El trabajo después de la clase obrera

    Directory of Open Access Journals (Sweden)

    ARIS ACCORNERO

    1987-01-01

    Full Text Available Artículo que indaga sobre el inadecuado tratamiento sociológico de la creciente clase de trabajadores manuales situados fuera de la industria tradicional. Se examinan el papel metodológico e ideológico del concepto "clase trabajadora" en la teoría marxista. La tradicional asociación marxista de trabajo productivo con trabajo industrial da lugar a una carencia de comprensión sociológica de la energía social de los trabajadores del sector servicios. Además, los trabajadores de fábrica pierden su propia imagen e identidad subjetivas de clase. La pregunta que se plantea es cómo definir correctamente los nuevos conceptos relacionados con el trabajo si el viejo concepto de clase trabajadora ha quedado obsoleto. Central para esta cuestión es la cohesión entre los diferentes grupos de trabajadores.

  8. Marx y su visión del trabajo

    Directory of Open Access Journals (Sweden)

    Héctor Ruiz Ramírez

    2013-06-01

    Full Text Available A partir de la elaboración de su Teoría del Valor-Trabajo, Marx sienta las bases del análisis del trabajo. El presente artículo pretende presentar de manera muy sucinta, algunos rasgos biográficos de Carlos Marx que permitan situarnos en el contexto en que nacen tan importantes aportaciones; y los elementos que el autor consideró importantes para tratar de entender la concepción marxista del trabajo, así como su relación con otras variables, tales como la acumulación de capital, la tecnología y la crisis económica.

  9. La postemancipación y trabajo en Cuba

    Directory of Open Access Journals (Sweden)

    Michael Zeuske

    2015-02-01

    Full Text Available Este artículo analiza los procesos de transculturación y fecundación mutua entre los espacios de trabajo en la postemancipación. El caso de Cuba es complejo, pues se dio en una época de desestructuración progresiva de la esclavitud, jalonada por guerras anticoloniales y una modernización tecnológica ininterrumpida. Se argumenta que aunque las condiciones de trabajo no mejoraron en lo sustancial, sí lo hizo la división sexual del trabajo, los patrones de movilidad, y el acceso a la propiedad informal de la tierra. La modernización de Cuba como productor azucarero introdujo fuerzas de inmenso calado en las luchas sociales del período.

  10. Régimen jurídico del trabajo rural

    Directory of Open Access Journals (Sweden)

    Héctor Zapirain

    2014-01-01

    Full Text Available La explotación rural se encuentra sujeta a diversos factores que le otorgan características singulares. Se trata de una actividad asentada preponderantemente en el campo donde el uso de la tierra es esencial. Actividad que, en su ejecución y resultado, depende estrechamente de la naturaleza, de los ciclos biológicos y de las variaciones climáticas. Existe una distancia entre tiempo de trabajo y tiempo de producción. Esta explica, entre otras causas, la tendencia a la precarización de la mano de obra rural. El trabajo regular o permanente, a tiempo completo y remunerado, no es la modalidad predominante, principalmente de países en desarrollo. Esas particularidades han contribuido a la creación de una legislación especial. Una práctica que se observa en la legislación laboral comparada. Orientación que ha influido en el legislador uruguayo.Introducción. Primera parte. Conceptos generales: Trabajo rural (agrario. Peculiaridades especiales de la actividad rural. La reglamentación del trabajo en el agro. Segunda parte. Estatuto del trabajador rural: Breve reseña de la evolución legislativa.  Precisiones pertinentes. Trabajador rural. Tiempo de trabajo y régimen de descansos. Feriados y vacaciones anuales. Salario y beneficios complementarios. Otras prestaciones a cargo del empleador rural. Seguridad y salud en el trabajo. Régimen de despido. Contralor administrativo 

  11. La crisis financiera global y el Derecho del Trabajo

    Directory of Open Access Journals (Sweden)

    Oscar Ermida Uriarte

    2014-03-01

    Full Text Available Hace tiempo que la frase acuñada por Palomeque, según la cual la crisis económica es "una compañera de viaje histórica del Derecho del trabajo", se convirtió en tópico del Derecho laboral. Mucho antes aún, en 1922, Sinzheimer había señalado que la interferencia Economía-Derecho laboral era inevitable -se podría decir estructural-, por cuanto "corresponde al Derecho del trabajo determinar la forma en que se dispone de los instrumentos y del producto del trabajo". Y siendo el laboral "un Derecho de la distribución" , el cumplimiento de esa función se vuelve más difícil y ríspida en períodos de dificultades económicas, porque si bien no es verdad que inevitablemente la torta deba crecer primero para recién después ser repartida, sí es cierto que la escasez complica y "conflictiviza" la distribución. Por tanto, la emergencia o el simple anuncio de la posibilidad de una crisis económica, produce efectos negativos sobre las relaciones de trabajo.Contenido: Crisis económica y Derecho del trabajo: una relación histórica. La crisis desatada en el ámbito financiero internacional en 2008. Efectos específicos de la crisis sobre el Derecho del trabajo. Algunos ejemplos nacionales concretos. Instrumentos laborales de anticipación o previsión. Conclusiones y sugerencias

  12. Beyond TGFβ : Novel ways to target airway and parenchymal fibrosis

    NARCIS (Netherlands)

    Boorsma, C. E.; Dekkers, B. G. J.; van Dijk, E. M.; Kumawat, K.; Richardson, J.; Burgess, J.K.; John, A. E.

    2014-01-01

    Within the lungs, fibrosis can affect both the parenchyma and the airways. Fibrosis is a hallmark pathological change in the parenchyma in patients with idiopathic pulmonary fibrosis (IPF), whilst in asthma or chronic obstructive pulmonary disease (COPD) fibrosis is a component of the remodelling of

  13. Inhaled mannitol for cystic fibrosis.

    Science.gov (United States)

    Nevitt, Sarah J; Thornton, Judith; Murray, Clare S; Dwyer, Tiffany

    2018-02-09

    Several agents are used to clear secretions from the airways of people with cystic fibrosis. Mannitol increases mucociliary clearance, but its exact mechanism of action is unknown. The dry powder formulation of mannitol may be more convenient and easier to use compared with established agents which require delivery via a nebuliser. Phase III trials of inhaled dry powder mannitol for the treatment of cystic fibrosis have been completed and it is now available in Australia and some countries in Europe. This is an update of a previous review. To assess whether inhaled dry powder mannitol is well tolerated, whether it improves the quality of life and respiratory function in people with cystic fibrosis and which adverse events are associated with the treatment. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises references identified from comprehensive electronic databases, handsearching relevant journals and abstracts from conferences.Date of last search: 28 September 2017. All randomised controlled studies comparing mannitol with placebo, active inhaled comparators (for example, hypertonic saline or dornase alfa) or with no treatment. Authors independently assessed studies for inclusion, carried out data extraction and assessed the risk of bias in included studies. The quality of the evidence was assessed using GRADE. Six studies (reported in 50 publications) were included with a total of 784 participants.Duration of treatment in the included studies ranged from 12 days to six months, with open-label treatment for an additional six months in two of the studies. Five studies compared mannitol with control (a very low dose of mannitol or non-respirable mannitol) and the final study compared mannitol to dornase alfa alone and to mannitol plus dornase alfa. Two large studies had a similar parallel design and provided data for 600 participants, which could be pooled where data for a particular outcome and time point were

  14. Trabajo remunerado, trabajo doméstico y salud: las diferencias cualitativas y cuantitativas entre mujeres y varones

    Directory of Open Access Journals (Sweden)

    Adriana Cecilia Cruz

    2003-08-01

    Full Text Available En este artículo se plantea la relación entre trabajo remunerado, trabajo doméstico y salud, desde la perspectiva de género. La relación entre ambos tipos de trabajo determina las características y el significado de la vida cotidiana. La metodología utilizada conjuntó técnicas cuantitativas y cualitativas. Se aplicó un cuestionario individual a 256 trabajadores y 121 trabajadoras (n = 377 de una moderna industria farmacéutica en México. También se hicieron siete entrevistas en profundidad entre trabajadores seleccionados por conveniencia. Los hallazgos principales muestran que a pesar de las enormes similitudes encontradas en el trabajo asalariado entre mujeres y varones, las diferencias pueden resumirse en dos conjuntos: por un lado, las distintas formas de segregación de género en el mercado de trabajo y, por el otro, en las formas de enfrentar la vida cotidiana. Se puede decir que los determinantes sociales que han cobijado esta desigual situación son resultado de la complejidad de las relaciones de género y dan lugar a diferentes perfiles patológicos y concepciones sobre la salud.

  15. Efectos de los equipos de trabajo autogestionados (EQTA y del trabajo individual sobre características grupales e individuales

    Directory of Open Access Journals (Sweden)

    AITOR ARITZETA

    2001-01-01

    Full Text Available El presente trabajo observa la medida en la que la estructuración de los trabajadores, de una empresa de automoción, a partir de Equipos de Trabajo Autogestionados EQTA tiene efectos significativos con respecto a las 19 características grupales relacionadas con la efectividad(Campion, Medsker y Higgs, 1993. Partiendo de dos muestras estadísticamente independientes pertenecientes a la misma organización, se observa también, las diferencias que con respecto a la satisfacción laboral, compromiso grupal, autoestima y autonomía personal muestran los sujetos de los EQTA (N=188 y los que realizan su trabajo de forma individual (N= 44. Los resultados indican que los EQTA obtienen valores superiores, con respecto a los que trabajan individualmente, en 13 de las 19 características, estando 18 relacionadas con la satisfacción. Solamente 9 características se relacionaron con la satisfacción en los grupos de trabajo individual. El compromiso grupal, aunque estadísticamente igual en ambos grupos, aparece relacionado con la satisfacción en los EQTA. Los resultados obtenidos demuestran que los EQTA son beneficiosos, no solo económicamente, sino también para el desarrollo de los individuos en la organización. El trabajo tiene implicaciones para el diseño de los grupos autónomos en las organizaciones.

  16. Mercado de trabajo en Castilla y León

    OpenAIRE

    Pérez Arto, Sara

    2012-01-01

    El objetivo del presente trabajo consiste en desarrollar los aspectos más destacados del mercado de trabajo de Castilla y León, es una cuestión muy amplia de forma que hemos buscado dar unas pinceladas que nos muestren una visión global de tema, partiendo de una introducción histórica hasta centrarnos en la actualidad, estableciendo las comparaciones pertinentes con lo sucedido a esfera nacional. Intentando justificar en todo momento cada uno de los argumentos con datos e...

  17. El trabajo nocturno como factor de riesgo psicosocial

    Directory of Open Access Journals (Sweden)

    Mongui Sánchez Hilda Margoth

    1993-08-01

    Full Text Available

    Las tendencias actuales de la promoción de la seguridad integral, la higiene y el bienestar en el trabajo ya no sólo tienen en cuenta los factores de riesgo tradicionales físicos, químicos, biológicos, ergonómicos y de inseguridad del ambiente laboral, sino otra serie de factores psicosociales inherentes al tipo de empresa, a la organización del trabajo y al clima organizacional que puedan influir sustancialmente en el bienestar físico mental y social del trabajador.

  18. Guatemala cafetalera: tierra, trabajo y política

    OpenAIRE

    Gudmundson K, Lowell

    2012-01-01

    IntroducciónHace ya casi una década, el historiador guatemalteco Julio Castellanos Cambranes presentó el primer volumen de lo que se anunciaba como una trilogía sobre la historia agraria de su país. A partir de 1992 nos ofrece una compilación en dos volúmenes de historia agraria guatemalteca en donde se destacan los temas del café y de sus sistemas de trabajo y tenencia de tierra. Pero fuera del trabajo incansable de Cambranes es relativamente poco lo que se ha publicado recientemente en Guat...

  19. Mercado de trabajo y estrategias de valorización

    Directory of Open Access Journals (Sweden)

    IGNASI BRUNET ICART

    1998-01-01

    Full Text Available la tesis que se mantiene en este articulo es que un elemento para el analisis sociologico del mercado de trabajo es la subjetividad de los agentes de las relaciones laborales, tanto de los agentes de control -empresariado- como de los agentes controlados -asalariados-. comprender la construccion social de los agentes de las practicas es un requisito imprescindible para analizar las estrategias de los agentes de las relaciones laborales. se trata de evidenciar que las nuevas configuraciones del mundo de la empresa y del trabajo no estan dadas, sino que dependen de la interaccion de los agentes en un campo estrategico.

  20. El trabajo colaborativo y la inclusión social

    OpenAIRE

    Amelia Berenice Barragán de Anda; Patricia de Aguinaga Vázquez; Claudia Ávila González

    2010-01-01

    En este artículo se incluyen algunas reflexiones sobre el trabajo colaborativo y el impacto que éste tiene en el proceso de aprendizaje, no sólo en cuanto a la aprehensión de contenidos teórico-académicos, sino también a la adquisición de habilidades digitales, reconocimiento de actitudes, desarrollo de destrezas y aptitudes útiles para ser buen estudiante y para mejorar la práctica profesional a través de la convivencia generada por el trabajo colaborativo. El aprendizaje colaborativo posibi...

  1. La personalidad y los equipos de trabajo efectivos

    OpenAIRE

    Alcázar Pretelt, Erika

    2015-01-01

    Cuando un grupo de gente trabaja en pos de una meta en común, puede hablarse de trabajo en equipo. Sin embargo, hoy en día el problema se centra en cómo conseguir que el trabajo en equipo sea eficaz. Trabajar en equipo consiste en colaborar organizadamente para alcanzar un objetivo en común, entendiendo las interdependencias que se dan entre los miembros del equipo y sacar el máximo provecho de ellas para alcanzar el objetivo.

  2. Viral infection drives tissue fibrosis in vitro

    Directory of Open Access Journals (Sweden)

    Andrea P. Malizia

    2008-04-01

    Full Text Available Idiopathic Pulmonary Fibrosis (IPF is a refractory and lethal interstitial lung disease characterized by loss of alveolar epithelial cells, fibroblast proliferation and extra-cellular matrix protein deposition. EBV, localised to alveolar epithelial cells of pulmonary fibrosis patients is associated with a poor prognosis. In this study we utilised a microarray-based differential gene expression analysis strategy to identify molecular drivers of EBV associated with lung fibrosis. A549 cells and an alveolar epithelial cell line infected with EBV (VAAK were used to identify genes whose expression was altered by EBV reactivation. EBV reactivation by TGFbeta1 drives alterations in expression of non-canonical Wnt pathway mediators, implicating it in epithelial mesenchymal transition (EMT, the molecular event underpinning scar production in tissue fibrosis. Cell invasion, EMT correlated transcripts expression, GSK-3b and c-Jun activation were altered in response to non-canonical Wnt pathway regulation. The role of EBV in promoting fibrosis can be attenuated by antiviral strategies and inhibition of Wnt signalling. Activation of non-canonical Wnt signalling pathway by EBV in epithelial cells suggests a novel mechanism of tissue fibrosis. These data present a framework for further description of the link between infectious agents and fibrosis, a significant disease burden.

  3. Role of Circulating Fibrocytes in Cardiac Fibrosis.

    Science.gov (United States)

    Lin, Rong-Jie; Su, Zi-Zhuo; Liang, Shu-Min; Chen, Yu-Yang; Shu, Xiao-Rong; Nie, Ru-Qiong; Wang, Jing-Feng; Xie, Shuang-Lun

    2016-02-05

    It is revealed that circulating fibrocytes are elevated in patients/animals with cardiac fibrosis, and this review aims to provide an introduction to circulating fibrocytes and their role in cardiac fibrosis. This review is based on the data from 1994 to present obtained from PubMed. The search terms were "circulating fibrocytes " and "cardiac fibrosis ". Articles and critical reviews, which are related to circulating fibrocytes and cardiac fibrosis, were selected. Circulating fibrocytes, which are derived from hematopoietic stem cells, represent a subset of peripheral blood mononuclear cells exhibiting mixed morphological and molecular characteristics of hematopoietic and mesenchymal cells (CD34+/CD45+/collagen I+). They can produce extracellular matrix and many cytokines. It is shown that circulating fibrocytes participate in many fibrotic diseases, including cardiac fibrosis. Evidence accumulated in recent years shows that aging individuals and patients with hypertension, heart failure, coronary heart disease, and atrial fibrillation have more circulating fibrocytes in peripheral blood and/or heart tissue, and this elevation of circulating fibrocytes is correlated with the degree of fibrosis in the hearts. Circulating fibrocytes are effector cells in cardiac fibrosis.

  4. Sputum eosinophilia in idiopathic pulmonary fibrosis.

    Science.gov (United States)

    Birring, S S; Parker, D; McKenna, S; Hargadon, B; Brightling, C E; Pavord, I D; Bradding, P

    2005-02-01

    Cough is a common symptom in idiopathic pulmonary fibrosis that is difficult to treat and has a major impact on quality of life. We tested the hypothesis that the cough and increased cough reflex sensitivity seen in patients with idiopathic pulmonary fibrosis may be due to airway inflammation in a prospective, cross-sectional study. We measured the induced sputum inflammatory cell profile and cell-free supernatant inflammatory mediator concentrations in 15 patients with idiopathic pulmonary fibrosis, 17 healthy controls and 15 patients with chronic obstructive pulmonary disease. Both the geometric mean sputum differential eosinophil cell count and median eosinophilic-cationic-protein concentration were significantly higher in patients with idiopathic pulmonary fibrosis than controls (2.1% vs 0.3%; p <0.001 and 1.1 mg/ml versus 0.2 mg/ml; p=0.03 respectively). There were no significant differences in sputum eosinophil counts and eosinophilic-cationic-protein concentrations between patients with idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Sputum leukotriene-B4 concentrations were significantly lower in patients with idiopathic pulmonary fibrosis (p=0.03) and chronic obstructive pulmonary disease (p=0.008) compared to controls. Idiopathic pulmonary fibrosis is characterised by the presence of active eosinophilic airway inflammation raising the possibility that airway inflammation may contribute to symptoms such as cough.

  5. Nanoparticles for the treatment of liver fibrosis

    Directory of Open Access Journals (Sweden)

    Poilil Surendran S

    2017-09-01

    Full Text Available Suchithra Poilil Surendran, Reju George Thomas, Myeong Ju Moon, Yong Yeon Jeong Department of Radiology, BioMolecular Theranostics (BiT Lab, Chonnam National University Medical School, Chonnam National University Hwasun Hospital (CNUHH, South Korea Abstract: Chronic liver diseases represent a global health problem due to their high prevalence worldwide and the limited available curative treatment options. They can result from various causes, both infectious and noninfectious diseases. The application of nanoparticle (NP systems has emerged as a rapidly evolving area of interest for the safe delivery of various drugs and nucleic acids for chronic liver diseases. This review presents the pathogenesis, diagnosis and the emerging nanoparticulate systems used in the treatment of chronic liver diseases caused by liver fibrosis. Activated hepatic stellate cell (HSC is considered to be the main mechanism for liver fibrosis. Ultrasonography and magnetic resonance imaging techniques are widely used noninvasive diagnostic methods for hepatic fibrosis. A variety of nanoparticulate systems are mainly focused on targeting HSC in the treatment of hepatic fibrosis. As early liver fibrosis is reversible by current NP therapy, it is being studied in preclinical as well as clinical trials. Among various nanoparticulate systems, inorganic NPs, liposomes and nanomicelles have been widely studied due to their distinct properties to deliver drugs as well as other therapeutic moieties. Liposomal NPs in clinical trials is considered to be a milestone in the treatment of hepatic fibrosis. Currently, NP therapy for liver fibrosis is updating fast, and hopefully, it can be the future remedy for liver fibrosis. Keywords: liver fibrosis, inorganic nanoparticles, liposomes, micelles

  6. Transient elastography for liver fibrosis diagnosis

    DEFF Research Database (Denmark)

    Andersen, Ellen Sloth; Christensen, Peer Brehm; Weis, Nina

    2009-01-01

    Liver biopsy is considered the "golden standard" for assessment of hepatic fibrosis. However, the procedure has limitations because of inconvenience and rare but serious complications as bleeding. Furthermore, sampling errors are frequent, and interobserver variability often poses problems....... Recently, a modified ultrasound scanner (transient elastography) has been developed to assess fibrosis. The device measures liver elasticity, which correlates well with the degree of fibrosis. Studies have shown that transient elastography is more accurate in diagnosing cirrhosis than minor to moderate...... to be a valuable diagnostic procedure and follow-up of patients with chronic liver diseases....

  7. Noninvasive Biomarkers of Liver Fibrosis: An Overview

    Directory of Open Access Journals (Sweden)

    Hind I. Fallatah

    2014-01-01

    Full Text Available Chronic liver diseases of differing etiologies are among the leading causes of mortality and morbidity worldwide. Establishing accurate staging of liver disease is very important for enabling both therapeutic decisions and prognostic evaluations. A liver biopsy is considered the gold standard for assessing the stage of hepatic fibrosis, but it has many limitations. During the last decade, several noninvasive markers for assessing the stage of hepatic fibrosis have been developed. Some have been well validated and are comparable to liver biopsy. This paper will focus on the various noninvasive biochemical markers used to stage liver fibrosis.

  8. Vitamin D deficiency as a risk factor for cystic fibrosis-related diabetes in the Scandinavian Cystic Fibrosis Nutritional Study

    DEFF Research Database (Denmark)

    Pincikova, T; Nilsson, Kristine Kahr; Moen, I E

    2011-01-01

    Many cystic fibrosis patients are vitamin D-insufficient. Cystic fibrosis-related diabetes is a major complication of cystic fibrosis. The literature suggests that vitamin D might possess certain glucose-lowering properties. We aimed to assess the relationship between vitamin D and cystic fibrosis...

  9. Cystic fibrosis-related diabetes

    DEFF Research Database (Denmark)

    Andersen, Henrik Ullits; Lanng, Susanne; Pressler, Tania

    2006-01-01

    OBJECTIVE: Cystic fibrosis (CF)-related diabetes has been regarded as a mild form of diabetes with a low risk of severe diabetes complications. The prevalence of CF-related diabetes increases with age, resulting in a 50% prevalence of diabetes at age 30 years. We sought to investigate whether...... microvascular complications in CF-related diabetes appear with a relevant frequency. RESEARCH DESIGN AND METHODS: Thirty-eight patients aged 30 (range 18-55) years with CF-related diabetes for 20 (0-31) years were screened for diabetes complications. Because of chronic pulmonary infections, the majority...... of diabetic retinopathy was found in patients with insulin-treated CF-related diabetes, stressing the need for a regular screening program as in type 1 diabetes. Severely impaired kidney function was common in lung transplant patients, probably secondary to cyclosporine treatment....

  10. Retroperitoneal fibrosis: findings with MR

    International Nuclear Information System (INIS)

    Martinez Rodrigo, J.; Marti-Bonnati, L.; Diago, T.; Ferrer, M.D.; Aleixandre, A.; Morote, V.

    1993-01-01

    Retroperitoneal fibrosis (RF) is an uncommon disease characterized by the presence of a chronic inflammatory reaction, with the formation of fibrous tissue that replaces the normal retroperitoneal tissue, trapping vessels and/or ureters. We present a retrospective review of 3 cases of idiopathic RF studied by means of ultrasound, CT scan and MR imaging, and we assess the features of the MR image, as well as its capacity for characterizing the lesion. We compare the findings obtained with 3 imaging techniques, describing the utility of each one, and their advantages and disadvantages in the assessment of this pathology. In MR, idiopathic RF appears as a hypodense mass in SET1, SE-T2 and STIR sequences. (Author) 9 ref

  11. Pathogenesis of Idiopathic Pulmonary Fibrosis

    Science.gov (United States)

    Wolters, Paul J.; Collard, Harold R.; Jones, Kirk D.

    2014-01-01

    Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease associated with aging that is characterized by the histopathological pattern of usual interstitial pneumonia. Although an understanding of the pathogenesis of IPF is incomplete, recent advances delineating specific clinical and pathologic features of IPF have led to better definition of the molecular pathways that are pathologically activated in the disease. In this review we highlight several of these advances, with a focus on genetic predisposition to IPF and how genetic changes, which occur primarily in epithelial cells, lead to activation of profibrotic pathways in epithelial cells. We then discuss the pathologic changes within IPF fibroblasts and the extracellular matrix, and we conclude with a summary of how these profibrotic pathways may be interrelated. PMID:24050627

  12. Drogodependencias en el lugar de trabajo: Pautas generales de intervención desde la medicina del trabajo

    Directory of Open Access Journals (Sweden)

    Carmen Otero Dorrego

    Full Text Available El abuso de drogas es un importante problema de salud pública, así como un grave problema laboral en los países industrializados. Las serias consecuencias laborales (menor rendimiento, aumento del número de accidentes, etc y la posibillidad de abordar el problema con éxito desde los servicios de salud laboral de las empresas, hacen necesarias la creación de políticas y programas de intervención. El objetivo general de todos estos programas es conseguir la rehabilitación personal y laboral de los trabajadores afectados. Otros objetivos secundarios son mejorar los índices de absentismo y accidentabilidad, esta blecer pautas generales de actuación de los médicos del trabajo para intervenir en las situaciones de abuso de drogas en el lugar de trabajo, así como favorecer la reincorporación laboral adecuada de los trabajadores que han seguido un programa de deshabituación. En este artículo se hace una revisión de datos epidemiológicos, consecuencias laborales, personales y sociales, diferentes normas y recomendaciones internacionales y nacionales, así como de programas específicos de empresas nacionales y extranjeras en los diferentes sectores de producción. Por último, se describen las pautas generales de actuación de los médicos del trabajo de los servicios de salud laboral. Las actuaciones del Médico del trabajo en el ámbito de la Prevención Primaria se dirigirán a la detección de factores de riesgo en el puesto de trabajo (evaluación de riesgos psicosociales y facilidad de acceso a drogas en el trabajo, entre otros y factores individuales (detección precoz de trabajadores especialmente sensibles, aplicando medidas correctoras (formativas e informativas, adaptación de puestos de trabajo, etc.. El médico del trabajo también se ocupará de realizar un diagnóstico precoz (Prevención Secundaria para tratamiento de desintoxicación y deshabituación a través de la red asistencial del Sistema Nacional de Salud. Y, por

  13. Cambios morfológicos, celulares y moleculares en la fibrosis renal debido al envejecimiento

    Directory of Open Access Journals (Sweden)

    Miguel Alaga

    2015-11-01

    Full Text Available En los últimos 50 años se ha registrado un aumento gradual de la tasa de envejecimiento de la población uruguaya, reflejándose en un incremento de pacientes con enfermedad renal crónica mayores de 65 años. Este fenómeno plantea la interrogante de cómo el envejecimiento tisular afecta la función del riñón y, en particular cómo contribuye al desarrollo de la fibrosis renal. Con el envejecimiento se producen cambios morfológicos y funcionales en el riñón, tales como la esclerosis glomerular y la fibrosis intersticial. Estos cambios son consecuencia de alteraciones que ocurren a nivel celular. En este trabajo se profundizará en los mecanismos celulares que desencadenan la fibrosis intersticial y la gloméruloesclerosis, describiendo el proceso de inflamación sostenida, la transformación fenotípica de las células epiteliales a miofibroblastos, así como los mecanismos de producción de matriz extracelular y la perpetuación de la fibrosis renal. Además, detallaremos las cascadas moleculares involucradas en el proceso de fibrosis, poniendo énfasis en las cascadas reguladas por TGF-β1 y sus vías de interacción, que regulan la producción factores pro- y anti-fibróticos. También veremos como el TGF-β1 modula la expresión de ARN pequeños no-codificantes (microARNs, potentes inhibidores de la expresión génica, y como el gen anti-envejecimiento Klotho inhibe el avance de la fibrosis renal. Finalmente, discutiremos terapias para frenar o enlentecer el proceso de fibrosis renal, especialmente aquellas que tengan como blanco las cascadas de señalización activadas por TGF-β1, los microRNAs y posibles terapias de activación del gen Klotho para prevenir la progresión de esta patología.

  14. La trata de personas en la modalidad de trabajo infantil

    Directory of Open Access Journals (Sweden)

    Angélica García Marbella

    2017-01-01

    Full Text Available En este trabajo se describen las causas y el proceso evolutivo del trabajo infantil en México; sin embargo, en la exposición se retoman elementos que identifican el problema en el contexto mundial. En ese sentido, se destaca que durante algún tiempo el quehacer de los infantes en el mercado de trabajo era considerado como un medio para que aprendieran determinado oficio, así como que dicha connotación no ha dejado de existir, pero ahora coexiste con otras tendencias asociadas a la delincuencia organizada, tales como prostitución, pornografía y turismo infantil; es decir, con actividades vinculadas estrechamente con la trata de personas. La pretensión es evidenciar el problema y las principales prácticas de quienes llevan a cabo dicho comportamiento; por lo que hubo necesidad de recurrir a la aplicación de una entrevista focalizada, basada en ocho informantes, con la finalidad de conocer la percepción de personas involucradas en dicha problemática. Al final del trabajo, lo observado es que la problemática en cuestión sigue creciendo en México; situación que es corroborada por los datos que aportan diversas instituciones, que señalan que en la actualidad este país ocupa el primer lugar en dicho comportamiento.

  15. Historia del trabajo social latinoamericano. Estado del arte

    Directory of Open Access Journals (Sweden)

    Gloria E. Leal L.

    2006-01-01

    Full Text Available La literatura sobre la historia del trabajo social latinoamericano contiene vacíos importantes y planteamientos de lo que significó el desarrollo de la profesionalización en los años setenta y en el período de la reconceptualización. Por tal razón es indi

  16. 90.000 trabajos disponibles en Digital.CSIC

    OpenAIRE

    Oficina Técnica de Digital.CSIC; Román-Molina, Juan

    2014-01-01

    Póster elaborado al alcanzar el repositorio los 90.000 trabajos.-- Se incluye versión en formato PDF.-- El resto de los hitos está disponible en la siguiente url: http://digital.csic.es/enCifras/crecimientoLineal.jsp

  17. Condiciones de trabajo y salud de mototaxistas Cartagena - Colombia

    Directory of Open Access Journals (Sweden)

    Irma Yolanda Castillo Avila

    2013-01-01

    Full Text Available Objetivo: Determinar las condiciones de trabajo y salud de los moto-taxistas de la ciudad de Cartagena. Metodología: Se realizó un estudio descriptivo, con una muestra de 423 moto-taxistas de la ciudad, elegidos por muestreo aleatorio por conglomerados. Para la recolección de información fue utilizada una encuesta socio-demográfica y una adaptación de la VI En- cuesta Nacional de Condiciones de Trabajo del Instituto Nacional de Seguridad e Higiene en el Trabajo de España. Se aplicó estadística descriptiva a los datos utilizando el programa estadístico SPSSS versión 17. Resultados: Participaron en el estudio 423 moto-taxistas, 97.9% (414 son hombres. El 46.3 % (196 son bachilleres y el 2.1% (9 han finalizado estudios universitarios. En cuanto a las condiciones de trabajo y salud, el 54.8% (232 manifestaron ser trabajadores independientes propietarios de las motos. El 18.2% (77 aseguro estar expuesto a ruido elevado, 40.7% (173 debe trabajar con lluvia, 91% (385 respira polvos y humos durante la realización de su trabajo. La mediana de horas diarias laboradas es 10. El 53.7% (227 aseguraron no tener ningún tipo de afiliación a seguridad social; El 74.7% (316 consideran que su trabajo afecta su salud, siendo las afecciones más frecuentes: dolor de espalda 65.2% (276, dolor de cuello 34% (144 y enfermedades de la piel 25.5% (108. Conclusión: El moto-taxismo, es el tipo de trabajo informal más común en la ciudad de Cartagena. Los trabajadores no cuentan con afiliación al sistema general de seguridad social en salud, y trabajan en condiciones que ponen en riesgo su salud.

  18. Overexpression of Heme Oxygenase-1 Prevents Renal Interstitial Inflammation and Fibrosis Induced by Unilateral Ureter Obstruction.

    Directory of Open Access Journals (Sweden)

    Xiao Chen

    Full Text Available Renal fibrosis plays an important role in the onset and progression of chronic kidney diseases. Many studies have demonstrated that heme oxygenase-1 (HO-1 is involved in diverse biological processes as a cytoprotective molecule, including anti-inflammatory, anti-oxidant, anti-apoptotic, antiproliferative, and immunomodulatory effects. However, the mechanisms of HO-1 prevention in renal interstitial fibrosis remain unknown. In this study, HO-1 transgenic (TG mice were employed to investigate the effect of HO-1 on renal fibrosis using a unilateral ureter obstruction (UUO model and to explore the potential mechanisms. We found that HO-1 was adaptively upregulated in kidneys of both TG and wild type (WT mice after UUO. The levels of HO-1 mRNA and protein were increased in TG mice compared with WT mice under normal conditions. HO-1 expression was further enhanced after UUO and remained high during the entire experimental process. Renal interstitial fibrosis in the TG group was significantly attenuated compared with that in the WT group after UUO. Moreover, overexpression of HO-1 inhibited the loss of peritubular capillaries. In addition, UUO-induced activation and proliferation of myofibroblasts were suppressed by HO-1 overexpression. Furthermore, HO-1 restrained tubulointerstitial infiltration of macrophages and regulated the secretion of inflammatory cytokines in UUO mice. We also found that high expression of HO-1 inhibited reactivation of Wnt/β-catenin signaling, which could play a crucial role in attenuating renal fibrosis. In conclusion, these data suggest that HO-1 prevents renal tubulointerstitial fibrosis possibly by regulating the inflammatory response and Wnt/β-catenin signaling. This study provides evidence that augmentation of HO-1 levels may be a therapeutic strategy against renal interstitial fibrosis.

  19. Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Van Beneden, Katrien, E-mail: kvbenede@vub.ac.be [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Geers, Caroline [Department of Pathology, Universitair Ziekenhuis Brussel, Brussels (Belgium); Pauwels, Marina [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Mannaerts, Inge [Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Wissing, Karl M. [Department of Nephrology, Universitair Ziekenhuis Brussel, Brussels (Belgium); Van den Branden, Christiane [Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium); Grunsven, Leo A. van, E-mail: lvgrunsv@vub.ac.be [Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels (Belgium)

    2013-09-01

    Histone deacetylase (HDAC) inhibitors are promising new compounds for the therapy of fibrotic diseases. In this study we compared the effect of two HDAC inhibitors, trichostatin A and valproic acid, in an experimental model of kidney fibrosis. In mice, doxorubicin (adriamycin) can cause nephropathy characterized by chronic proteinuria, glomerular damage and interstitial inflammation and fibrosis, as seen in human focal segmental glomerulosclerosis. Two treatment regimens were applied, treatment was either started prior to the doxorubicin insult or delayed until a significant degree of proteinuria and fibrosis was present. Pre-treatment of trichostatin A significantly hampered glomerulosclerosis and tubulointerstitial fibrosis, as did the pre-treatment with valproic acid. In contrast, the development of proteinuria was only completely inhibited in the pre-treated valproic acid group, and not in the pre-treated trichostatin A animals. In the postponed treatment with valproic acid, a complete resolution of established doxorubicin-induced proteinuria was achieved within three days, whereas trichostatin A could not correct proteinuria in such a treatment regimen. However, both postponed regimens have comparable efficacy in maintaining the kidney fibrosis to the level reached at the start of the treatments. Moreover, not only the process of fibrosis, but also renal inflammation was attenuated by both HDAC inhibitors. Our data confirm a role for HDACs in renal fibrogenesis and point towards a therapeutic potential for HDAC inhibitors. The effect on renal disease progression and manifestation can however be different for individual HDAC inhibitors. - Highlights: • Valproic acid is a potent antiproteinuric drug, whereas trichostatin A is not. • Trichostatin A and valproic acid reduce kidney fibrosis in doxorubicin nephropathy. • Both valproic acid and trichostatin A attenuate renal inflammation.

  20. Nutrition in Cystic Fibrosis: Macro- and Micronutrients

    NARCIS (Netherlands)

    Oudshoorn, Johanna Hermiena

    2006-01-01

    Cystic fibrosis (CF) is the most common life-threatening autosomal recessive inherited disease in Caucasians, and is characterized by progressive lung disease, pancreatic insufficiency, malnutrition, hepatobiliary disease and elevated sweat electrolyte levels. The increased survival of CF patients

  1. Epigenetics and Liver FibrosisSummary

    Directory of Open Access Journals (Sweden)

    Eva Moran-Salvador

    2017-07-01

    Full Text Available Liver fibrosis arises because prolonged injury combined with excessive scar deposition within hepatic parenchyma arising from overactive wound healing response mediated by activated myofibroblasts. Fibrosis is the common end point for any type of chronic liver injury including alcoholic liver disease, nonalcoholic fatty liver disease, viral hepatitis, and cholestatic liver diseases. Although genetic influences are important, it is epigenetic mechanisms that have been shown to orchestrate many aspects of fibrogenesis in the liver. New discoveries in the field are leading toward the development of epigenetic biomarkers and targeted therapies. This review considers epigenetic mechanisms as well as recent advances in epigenetic programming in the context of hepatic fibrosis. Keywords: Liver Fibrosis, Epigenetics, DNA Methylation, Histone Modifications, Chronic Liver Disease

  2. Molecular and cellular mechanisms of pulmonary fibrosis

    Science.gov (United States)

    2012-01-01

    Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary fibrosis is considered the most common and severe form of the disease, with a median survival of approximately three years and no proven effective therapy. Despite the fact that effective treatments are absent and the precise mechanisms that drive fibrosis in most patients remain incompletely understood, an extensive body of scientific literature regarding pulmonary fibrosis has accumulated over the past 35 years. In this review, we discuss three broad areas which have been explored that may be responsible for the combination of altered lung fibroblasts, loss of alveolar epithelial cells, and excessive accumulation of ECM: inflammation and immune mechanisms, oxidative stress and oxidative signaling, and procoagulant mechanisms. We discuss each of these processes separately to facilitate clarity, but certainly significant interplay will occur amongst these pathways in patients with this disease. PMID:22824096

  3. Cystic fibrosis : a hereditary inflammatory process

    NARCIS (Netherlands)

    Terheggen-Lagro, S.W.J.

    2006-01-01

    Cystic fibrosis (CF) lung disease is characterized by an exaggerated, and extended inflammation, with a massive influx of neutrophils and high concentrations of interleukin (IL)-8 in bronchoalveolar lavage fluid (BALF). Furthermore, patients with CF have chronic bacterial airway infection,

  4. Liver Transplantation for Cirrhosis in Cystic Fibrosis

    Directory of Open Access Journals (Sweden)

    T Lamireau

    2006-01-01

    Full Text Available BACKGROUND: Liver disease is the third most common cause of death in children with cystic fibrosis (CF. Liver transplantation is an effective treatment in children with hepatic failure.

  5. Transient elastography for liver fibrosis diagnosis

    DEFF Research Database (Denmark)

    Andersen, Ellen Sloth; Christensen, Peer Brehm; Weis, Nina

    2008-01-01

    Liver biopsy is considered the "golden standard" for assessment of hepatic fibrosis. However, the procedure has limitations because of inconvenience and rare but serious complications as bleeding. Furthermore, sampling errors are frequent, and interobserver variability often poses problems...

  6. The impact of emphysema in pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Vincent Cottin

    2013-06-01

    Full Text Available Several groups have described a syndrome in which idiopathic pulmonary fibrosis (IPF coexists with pulmonary emphysema. This comes as no surprise since both diseases are associated with a history of exposure to cigarette smoke. The syndrome of combined pulmonary fibrosis and emphysema (CPFE is characterised by upper lobe emphysema and lower lobe fibrosis. Physiological testing of these patients reveals preserved lung volume indices contrasted by markedly impaired diffusion capacity. The incidence of CPFE remains unknown but several case series suggest that this subgroup may comprise up to 35% of patients with IPF. CPFE is a strong determinant of associated pulmonary hypertension (PH. In addition, CPFE has major effects on measures of physiological function, exercise capacity and prognosis, and may affect the results of pulmonary fibrosis trials. Further studies are needed to ascertain the aetiology, morbidity, mortality and management of the CPFE syndrome, with or without PH, and to evaluate novel therapeutic options in CPFE.

  7. Imaging findings in idiopathic pelvic fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Wiesner, W.; Bongartz, G. [Inst. of Diagnostic Radiology University Hospital Basel (Switzerland); Stoffel, F. [Inst. of Urology, University Hospital Basel (Switzerland)

    2001-04-01

    Two patients presented with ureteric obstruction, and voiding symptoms and constipation, respectively, and were examined by means of intravenous urography and computed tomography. One patient was additionally examined by means of MR tomography. After CT (performed in both patients) and MRT (performed in one patient) had shown a diffuse, contrast-enhancing, infiltrating process in the small pelvis with infiltration of adjacent organs and vessels, surgical biopsy proved the diagnosis of idopathic pelvic fibrosis. Extension of retroperitoneal fibrosis below the pelvic rim is very rare. Clinical symptoms of pelvic fibrosis are variable and imaging findings may lead to a broad list of differential diagnoses. We present two patients with idiopathic pelvic fibrosis and discuss radiological findings and differential diagnoses of this rare disease. (orig.)

  8. Liver Fibrosis: Current Principles of Diagnosis

    Directory of Open Access Journals (Sweden)

    A.K. Duda

    2014-09-01

    Full Text Available Liver fibrosis — a natural consequence of almost all liver diseases of any origin. We are faced with a number of standard stereotype processes that take place in the liver tissue. Mostly it is the processes of chronic inflammation, which oppose the processes of liver tissue regeneration. The basis of imbalance between the processes of fibrosis and regeneration is an accumulation of extracellular matrix. Liver fibrosis in its development leads to liver cirrhosis, hepatocellular carcinoma, and the increase in morbidity rate is observed worldwide. Furthermore, the process is genetically determined, but modifiable factors play an important role in the progression of this disease. Current data indicate the possibility of reversible liver fibrosis.

  9. Retroperitoneal fibrosis with normal intravenous urogram.

    OpenAIRE

    Creagh, F. M.; Stone, T.; Stephenson, T. P.; Lazarus, J. H.

    1985-01-01

    A 58 year old male presented with a two week history of low back pain and malaise. The intravenous urogram (IVU) at presentation was normal but within three months he had developed renal failure with bilateral ureteric obstruction on repeat IVU. Primary retroperitoneal fibrosis was confirmed at operation. This case demonstrates that retroperitoneal fibrosis may progress rapidly to renal failure within a few months of the first symptoms. In addition, the IVU may be normal in the early stages o...

  10. Cystic Fibrosis and gastroesophageal reflux disease.

    Science.gov (United States)

    Maqbool, Asim; Pauwels, Ans

    2017-11-01

    Gastroesophageal reflux is common in children and adults with cystic fibrosis (CF). Pathological gastroesophageal reflux disease (GERD) is also frequent in patients of all ages with CF. This article reviews the pathophysiology, diagnostic work-up, management options, complications, and future directions in the evaluation and management of GERD - unique to and pertinent for - patients with CF in particular. Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

  11. Festival food coma in cystic fibrosis.

    Science.gov (United States)

    Pandit, Chetan; Graham, Christie; Selvadurai, Hiran; Gaskin, Kevin; Cooper, Peter; van Asperen, Peter

    2013-07-01

    Children with cystic fibrosis liver disease and portal hypertension are at risk of developing acute hepatic encephalopathy. Even in the presence of normal synthetic liver function these children may have porto-systemic shunting. We report a case of an adolosecent who had cystic fibrosis liver disease and presented with life threatening hepatinc encephalopathy. This case illustrates that it is necessary to consider an appropriate dietary regimen in adolosecents with liver disease to prevent hepatic decompensation. Copyright © 2012 Wiley Periodicals, Inc.

  12. Trabajo y salud en la mujer: análisis comparativo de mujeres con trabajo remunerado y amas de casa

    Directory of Open Access Journals (Sweden)

    Mª E. ESCALERA IZQUIERDO

    2000-01-01

    Full Text Available El objetivo de este estudio es detectar y analizar las posibles diferencias en salud, tanto psicológica como física, en mujeres con roles múltiples y amas de casa en exclusiva. Todas ellas tenían hijas/os, pareja y bastantes, un trabajo remunerado. Además de las diferencias, se han estudiado otras variables con las que la salud pudiera estar relacionada como las condiciones de trabajo (tanto en el campo laboral como en el doméstico, familiares (afectivas y ayuda instrumental, la tensión entre roles y recursos (autoestima, conductas de salud y de riesgo, apoyo social, nivel educativo e ingresos. Los resultados mostraron que existía una gran diferencia en las variables que explicaban la salud de las mujeres según trabajasen o no fuera de casa y una tendencia hacia una mejor salud por parte de las mujeres con trabajo remunerado. Para ambos grupos las variables más relevantes para una mejor salud estuvieron relacionadas con las conductas de salud y de riesgo y la tensión entre roles. En las que trabajaban fuera de casa fueron muy significativas la autoestima y las variables relativas a sus roles familiares (relaciones con la pareja e hijos/as así como las condiciones del trabajo doméstico, por delante de las laborales.

  13. Inhibition of SIRT2 suppresses hepatic fibrosis.

    Science.gov (United States)

    Arteaga, Maribel; Shang, Na; Ding, Xianzhong; Yong, Sherri; Cotler, Scott J; Denning, Mitchell F; Shimamura, Takashi; Breslin, Peter; Lüscher, Bernhard; Qiu, Wei

    2016-06-01

    Liver fibrosis can progress to cirrhosis and result in serious complications of liver disease. The pathogenesis of liver fibrosis involves the activation of hepatic stellate cells (HSCs), the underlying mechanisms of which are not fully known. Emerging evidence suggests that the classic histone deacetylases play a role in liver fibrosis, but the role of another subfamily of histone deacetylases, the sirtuins, in the development of hepatic fibrosis remains unknown. In this study, we found that blocking the activity of sirtuin 2 (SIRT2) by using inhibitors or shRNAs significantly suppressed fibrogenic gene expression in HSCs. We further demonstrated that inhibition of SIRT2 results in the degradation of c-MYC, which is important for HSC activation. In addition, we discovered that inhibition of SIRT2 suppresses the phosphorylation of ERK, which is critical for the stabilization of c-MYC. Moreover, we found that Sirt2 deficiency attenuates the hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Furthermore, we showed that SIRT2, p-ERK, and c-MYC proteins are all overexpressed in human hepatic fibrotic tissues. These data suggest a critical role for the SIRT2/ERK/c-MYC axis in promoting hepatic fibrogenesis. Inhibition of the SIRT2/ERK/c-MYC axis represents a novel strategy to prevent and to potentially treat liver fibrosis and cirrhosis. Copyright © 2016 the American Physiological Society.

  14. Digital quantification of fibrosis in liver biopsy sections: description of a new method by Photoshop software.

    Science.gov (United States)

    Dahab, Gamal M; Kheriza, Mohamed M; El-Beltagi, Hussien M; Fouda, Abdel-Motaal M; El-Din, Osama A Sharaf

    2004-01-01

    The precise quantification of fibrous tissue in liver biopsy sections is extremely important in the classification, diagnosis and grading of chronic liver disease, as well as in evaluating the response to antifibrotic therapy. Because the recently described methods of digital image analysis of fibrosis in liver biopsy sections have major flaws, including the use of out-dated techniques in image processing, inadequate precision and inability to detect and quantify perisinusoidal fibrosis, we developed a new technique in computerized image analysis of liver biopsy sections based on Adobe Photoshop software. We prepared an experimental model of liver fibrosis involving treatment of rats with oral CCl4 for 6 weeks. After staining liver sections with Masson's trichrome, a series of computer operations were performed including (i) reconstitution of seamless widefield images from a number of acquired fields of liver sections; (ii) image size and solution adjustment; (iii) color correction; (iv) digital selection of a specified color range representing all fibrous tissue in the image and; (v) extraction and calculation. This technique is fully computerized with no manual interference at any step, and thus could be very reliable for objectively quantifying any pattern of fibrosis in liver biopsy sections and in assessing the response to antifibrotic therapy. It could also be a valuable tool in the precise assessment of antifibrotic therapy to other tissue regardless of the pattern of tissue or fibrosis.

  15. Acute rejection after kidney transplantation promotes graft fibrosis with elevated adenosine level in rat.

    Directory of Open Access Journals (Sweden)

    Mingliang Li

    Full Text Available Chronic allograft nephropathy is a worldwide issue with the major feature of progressive allograft fibrosis, eventually ending with graft loss. Adenosine has been demonstrated to play an important role in process of fibrosis. Our study aimed to investigate the relationship between adenosine and fibrosis in renal allograft acute rejection in rat.Wistar rats and SD rats were selected as experimental animals. Our study designed two groups. In the allograft transplantation group, kidneys of Wistar rats were orthotopically transplanted into SD rat recipients, the same species but not genetically identical, to induce acute rejection. Kidney transplantations of SD rats to SD rats which were genetically identical were served as the control. We established rat models and detected a series of indicators. All data were analyzed statistically. P<0.05 was considered statistically significant.Compared with the control group, levels of adenosine increased significantly in the allograft transplantation group, in which acute rejection was induced (P<0.05. Progressive allograft fibrosis as well as collagen deposition were observed.These findings suggested that level of adenosine was upregulated in acute rejection after kidney allograft transplantation in rat. Acute rejection may promote renal allograft fibrosis via the adenosine signaling pathways.

  16. Retorno al trabajo tras cáncer de mama

    Directory of Open Access Journals (Sweden)

    Araceli López-Guillén García

    Full Text Available Resumen El cáncer de mama frecuentemente es causa de largos procesos de baja. La duración media de las bajas por cáncer de mama es de unos 320 días, estando entre los tres procesos principales que causan bajas de más de 365 días junto con la lumbalgia y el trastorno ansioso depresivo. Cada año se producen 26.000 casos nuevos en España de los que en su mayoría se producen en plena edad laboral. La supervivencia a los cinco años entre mujeres de 30 a 60 años es del 86%. El cáncer de mama es la segunda causa de inicio de expedientes de incapacidad permanente a los doce meses, tras la lumbalgia. Sólo el 53% retomará el trabajo. El retorno al trabajo se vuelve dificultoso tanto por la intensidad y pauta espaciada de los tratamientos, como por la afectación de la calidad de vida, como por la ausencia prolongada del trabajo. Influyendo factores personales de la trabajadora, unos por ella misma, otros ligados al cáncer y su evolución, y factores laborales ligados al tipo de trabajo, riesgos, condiciones y exigencias del mismo y otros factores del mercado de trabajo; que todos ellos considerados no siempre hacen que la vuelta al trabajo sea posible. Material y método: Se han revisado hasta octubre de 2016 las siguientes bases de datos bibliográficas: SciELO, y PUBMED. Así como la Bibliografía y documentos de consulta citados en la misma. Conclusiones: Es preciso facilitar el retorno al trabajo, en especial de aquellos casos más complicados que han precisado de largas bajas pero aun así ya están curados o con una mejoría que permite trabajar. Ante el fenómeno del cáncer de mama y su impacte incapacitante, es preciso conocer el mismo con certeza por lo que se hace necesario la realización urgente del Mapa de Incapacidad en España. Para evitar controversias entre el alta médica para trabajar y la no aptitud para el trabajo debe de institucionalizarse el uso de la Ficha de Valoración Ocupacional. Ante la toma de decisiones es

  17. Estrategia Iberoamericana de Seguridad y Salud en el Trabajo: políticas públicas para un trabajo decente

    Directory of Open Access Journals (Sweden)

    Olga Beatriz Guzmán Suárez

    Full Text Available Resumen A través del presente artículo, se pretende realizar una revisión del marco institucional global y regional en materia de seguridad y salud en el trabajo con un enfoque de derechos humanos, cuyo eje central serán las estrategias adoptadas para la generación de políticas públicas, enfocadas en la prevención y protección de los trabajadores contra los riesgos laborales. El desarrollo e implementación de políticas públicas en materia de seguridad y salud en el trabajo, se constituye como uno de los retos que debe ser asumido con la participación de diferentes agentes sociales, en el marco del diálogo social y del enfoque de derechos. Para ello, surge la Estrategia Iberoamericana de Seguridad y Salud en el Trabajo (EISST, concebida como un instrumento recomendado a los gobiernos, organizaciones empresariales y sindicales, entidades aseguradoras, colectivos profesionales, sector educativo y la sociedad entre otros, para que se comprometan y adhieran a los objetivos establecidos en el documento y de esta manera establecer de forma consensuada, el marco general que rija la seguridad y salud en el escenario laboral actual de la región. A partir de una revisión sistemática de la literatura, se realiza la contextualización sobre políticas públicas en salud laboral. Se destaca la importancia de las estrategias en seguridad y salud en el trabajo, y la necesidad de desarrollar e implementar políticas públicas con enfoque de derechos humanos, así como políticas que estimulen el diálogo entre los agentes sociales, que promuevan el logro de un trabajo decente.

  18. Turnos de trabajo: ¿un factor de riesgo cardiovascular?

    Directory of Open Access Journals (Sweden)

    José Santana-Herrera

    Full Text Available Objetivos: Describir según la literatura existente si hay evidencia científica de que los turnos de trabajo son un factor de riesgo cardiovascular e identificar las intervenciones en los tipos de turno más efectivas para reducir dichos riesgos. Material y métodos: Se realizó una búsqueda bibliográfica en 10 bases de datos obteniéndose 13 artículos. El diseño de estos estudios fueron: 7 de intervención, 1 de cohortes, 1 casos control, 3 descriptivos transversales y un estudio piloto. Se agruparon los trabajos según la dirección y velocidad de rotación, ergonomía de los turnos y cambios en el número de turnos analizándose la modificación de los biomarcadores según el tipo de intervención. Resultados: La muestra total fue de 12.332 trabajadores. El cambio en la dirección de rotación del turno de trabajo de atrás hacia adelante mostró cambios favorables como disminución del nivel de glucosa, TG, Ác. Úrico y TAS. Rotaciones rápidas en sentido horario pueden ser beneficiosas observándose una disminución del colesterol total, relación colesterol total/LDL y un aumento de HDL. Al asociar la dirección y velocidad de rotación no se obtuvieron modificaciones significativas de los biomarcadores. El cambio ergonómico en los turnos disminuyo las alteraciones lipídicas, TA y FC. Finalmente la diabetes mellitus se vio influenciada negativamente cuando cambiamos de tres turnos a dos turnos de trabajo. Conclusiones: Los artículos publicados sugieren un impacto negativo del trabajo por turnos en el riesgo cardiovascular que puede modificarse favorablemente con cambios en la organización del trabajo (sistema de rotación rápido en sentido horario, turnos flexibles y rotaciones de tres turnos.

  19. Oxygen therapy for cystic fibrosis.

    Science.gov (United States)

    Elphick, Heather E; Mallory, George

    2013-07-25

    The most serious complications of cystic fibrosis (CF) relate to respiratory insufficiency. Oxygen supplementation therapy has long been a standard of care for individuals with chronic lung diseases associated with hypoxemia. Physicians commonly prescribe oxygen therapy for people with CF when hypoxemia occurs. However, it is unclear if empiric evidence is available to provide indications for this therapy with its financial costs and often profound impact on lifestyle. To assess whether oxygen therapy improves the longevity or quality of life of individuals with CF. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register, comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Latest search of Group's Trials Register: 15 May 2013. Randomized or quasi-randomized controlled trials comparing oxygen, administered at any concentration, by any route, in people with documented CF for any time period. Authors independently assessed the risk of bias for included studies and extracted data. This review includes 11 published studies (172 participants); only one examined long-term oxygen therapy (28 participants). There was no statistically significant improvement in survival, lung, or cardiac health. There was an improvement in regular attendance at school or work in those receiving oxygen therapy at 6 and 12 months. Four studies examined the effect of oxygen supplementation during sleep by polysomnography. Although oxygenation improved, mild hypercapnia was noted. Participants fell asleep quicker and spent a reduced percentage of total sleep time in rapid eye movement sleep, but there were no demonstrable improvements in qualitative sleep parameters. Six studies evaluated oxygen supplementation during exercise. Again, oxygenation improved, but mild hypercapnia resulted. Participants receiving oxygen therapy were able to exercise for a

  20. Gene therapy in cystic fibrosis.

    Science.gov (United States)

    Flotte, T R; Laube, B L

    2001-09-01

    Theoretically, cystic fibrosis transmembrane conductance regulator (CFTR) gene replacement during the neonatal period can decrease morbidity and mortality from cystic fibrosis (CF). In vivo gene transfers have been accomplished in CF patients. Choice of vector, mode of delivery to airways, translocation of genetic information, and sufficient expression level of the normalized CFTR gene are issues that currently are being addressed in the field. The advantages and limitations of viral vectors are a function of the parent virus. Viral vectors used in this setting include adenovirus (Ad) and adeno-associated virus (AAV). Initial studies with Ad vectors resulted in a vector that was efficient for gene transfer with dose-limiting inflammatory effects due to the large amount of viral protein delivered. The next generation of Ad vectors, with more viral coding sequence deletions, has a longer duration of activity and elicits a lesser degree of cell-mediated immunity in mice. A more recent generation of Ad vectors has no viral genes remaining. Despite these changes, the problem of humoral immunity remains with Ad vectors. A variety of strategies such as vector systems requiring single, or widely spaced, administrations, pharmacologic immunosuppression at administration, creation of a stealth vector, modification of immunogenic epitopes, or tolerance induction are being considered to circumvent humoral immunity. AAV vectors have been studied in animal and human models. They do not appear to induce inflammatory changes over a wide range of doses. The level of CFTR messenger RNA expression is difficult to ascertain with AAV vectors since the small size of the vector relative to the CFTR gene leaves no space for vector-specific sequences on which to base assays to distinguish endogenous from vector-expressed messenger RNA. In general, AAV vectors appear to be safe and have superior duration profiles. Cationic liposomes are lipid-DNA complexes. These vectors generally have been

  1. Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice.

    LENUS (Irish Health Repository)

    Robb, W B

    2010-03-01

    The amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine\\'s effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy.

  2. Culturas juveniles y trabajo social con jóvenes

    Directory of Open Access Journals (Sweden)

    GLADYS CASTIBLANCO-LEMUS

    2008-01-01

    Full Text Available Este trabajo tiene como propósito señalar algunas implicaciones teóricas y practicas de la relación entre la categoría culturas juveniles, concretamente desde los resultados del proyecto de investigación: Identidades juveniles: Música y producción cultural. Etnografía de agrupaciones Rave y hip hop rap en Bogotá y un conjunto de premisas conceptuales del trabajo social con jóvenes. Para tal efecto se abordarán tres aspectos: en primer lugar, se presenta una síntesis del proyecto destacando los más importantes resultados; en segundo lugar se plantean los referentes conceptuales que permiten establecer la relación y finalmente se señalan algunas pistas para incorporar otros contenidos para la actuación profesional con jóvenes.

  3. Violencia en el trabajo: investigaciones realizadas en Colombia

    Directory of Open Access Journals (Sweden)

    José Gabriel Carvajal Orozco

    2013-12-01

    Full Text Available El propósito de esta ponencia es mostrar los resultados de una exploración bibliográfica concerniente a las investigaciones llevadas a cabo en los últimos diez años, sobre el tema de la violencia en el lugar de trabajo. Se consultaron 16 artículos –5 empíricos, 11 teóricos–, publicados en revistas científicas colombianas, en universidades públicas y privadas, en instituciones gubernamentales y en bases de datos académicas. La ponencia está estructurada en tres partes: la primera presenta los aspectos metodológicos; la segunda expone los resultados de la exploración, donde se muestran las problemáticas que se han abordado en las investigaciones sobre violencia en el trabajo, y la tercera y última parte contiene las conclusiones acerca de los resultados obtenidos.

  4. La Investigación en el trabajo Popular

    Directory of Open Access Journals (Sweden)

    Carlos Crespo

    2015-01-01

    Full Text Available Temas trascendentes de este número son Historia del Nuevo Periodismo, Derecho Social a la información y La televisión: Teleopio del pueblo. Se agregan otros como la investigación en el trabajo popular, LA mujer rural , El audiovisual en el Ecuador y Cambios en la comunicación a raíz del NOMIC.

  5. Observaciones sobre accidentes de trabajo y enfermedades profesionales

    Directory of Open Access Journals (Sweden)

    Guillermo Sarmiento López

    1948-03-01

    Full Text Available En los tiempos antiguos no existía ley ni disposición alguna de carácter social que favoreciera a los trabajadores incapacitados por enfermedad o por accidente, por tanto, eran tratados como esclavos o considerados como animales. Los accidentes de trabajo y las enfermedades profesionales eran casi desconocidas antes de la introducción de la maquinaria en la industria, por lo cual no existía el derecho a indemnización por concepto de daños que sufriera el trabajador en el desempeño de sus labores. Solamente se conocen los edictos de Rotari (año 645 de la éra cristiana lanzados en Italia con el fin de reparar los accidentes de los obreros de la construcción y después, en la época del Renacimiento, algunas publicaciones que hablan de ciertas enfermedades de los trabajadores (Ellemborg 1473, Paracelso 1493-1541. Ya en la edad media la industria comenzó a tomar cierta importancia y dada la escasez de brazos, se vio obligado el patrón por fuerza de las circunstancias a prestar ayuda económica a los trabajadores incapacitados por una u otra causa. Los accidentes sucedidos en las industrias no se consideraban como de trabajo, por no conocerse el peligro que envolvía el empleo de la maqumana. En el siglo XVII y a principios del XVIII un médico italiano, Ramazzini habla del perjuicio que ocasionan ciertos trabajos en el organismo del individuo, produciendo alteraciones anatómicas y funcionales. Solamente a fines del siglo XVIII y a principios del XIX con la producción en masa, con el aumento del número de obreros y con la falta de protección, empezaron los accidentes de trabajo a hacerse notorios.

  6. Flexibilidad del trabajo: discurso y construcción social

    Directory of Open Access Journals (Sweden)

    Enrique de la Garza Toledo

    2000-01-01

    Full Text Available A lo largo de este artículo se presentan diversas teorías y experiencias de flexibilidad laboral en México. El texto se inicia con un resumen de las principales teorías y argumentos discursivos sobre la flexibilización del trabajo en América Latina. Posteriormente se analiza el caso mexicano y sus distintas etapas: 1 de 1980 a 1992, caracterizada por una flexibilización unilateral y el inicio de un nuevo modelo económico; 2 de 1992 a 1994, en que se busca construir una nueva flexibilidad con intervención sindical, pero dirigida por las empresas; y 3 a partir de 1995, se intenta crear una alianza entre empresas y sindicatos mediante la firma de convenios de productividad, sin mucho éxito, y aparecen importantes disidencias en el sindicalismo oficial . Entre otros aspectos, el trabajo muestra que la ventaja comparativa del bajo salario continúa jugando un papel determinante y constituye uno de los factores que provocan que la modernización de las empresas exportadoras en México no sea muy pronunciada .Asimismo, argumenta que las características de la Ley Federal del Trabajo, los Contratos Colectivos de Trabajo, las diferentes estrategias empresariales de modernización y las particularidades de las relaciones industriales y el sistema político mexicano son elementos que explican las causas de la limitada extensión de la flexibilidad laboral en México.

  7. Reflections on Los trabajos de Persiles y Sigismunda, historia setentrional

    Directory of Open Access Journals (Sweden)

    Juan Ramón Muñoz Sánchez

    2015-12-01

    Full Text Available In the present study the three fundamental aspects of Los trabajos de Persiles y Sigismunda are analysed by parting from the dates which Cervantes offers in the preamble and the text of the books which he published year after year between 1613 and 1615: the composition, the intertextual relation with the Ethiopian Story by Heliodorus and its categorisation as a «book of entertainment».

  8. Control y supervisión de los trabajos verticales

    OpenAIRE

    Sirvent Pérez, César Daniel

    2012-01-01

    El siguiente artículo aborda una serie de conceptos relacionados con los trabajos verticales, desde el punto de vista del técnico encargado de controlar las obras (antes del inicio) y supervisar (durante el transcurso) en las que intervengan equipos de operarios especialistas. Su autor es el Arquitecto Técnico César Daniel Sirvent, director de la Oficina Técnica Altur y profesor de la Universidad de Alicante.

  9. LOS APORTES DEL TRABAJO SOCIAL AL TEMA DE FAMILIA

    Directory of Open Access Journals (Sweden)

    Angela María Quintero Velásquez

    2012-08-01

    Full Text Available El artículo presenta las contribuciones del Trabajo Social en los procesos familiares del continente. Refiere modalidades de la acción tales como: economapa. formas alternativas de enfrentar los conflictos socio-familiares, grupos psicoeducativos, redes. Precisa algunos elementos de la intervención: constructivismo, enfoque de convergencia (interinstitucionalidad, intersectorialidad, interdisciplinariedad, cibernética, relaciones ecosistemicas. la familia como sistema social.

  10. DOCUMENTO: FUNCIÓN Y PROFESIONALIDAD DEL TRABAJO SOCIAL

    Directory of Open Access Journals (Sweden)

    Cristina De Robertis

    2009-08-01

    Full Text Available Desde su surgimiento a fines del siglo XIX, la historia del Trabajo Social francés nos muestra períodos de creación y de transformación de la profesión. Durante las guerras del siglo XX los trabajadores sociales desplegaron capacidad de adaptación y de resistencia en esos períodos tan difíciles, sometidos a tensiones y decisiones éticas importantes. Después de Mayo del 68, el Trabajo Social fué criticado y analizado en términos de normalización y de control de la población, en su rol, según Althuser, de “aparato ideológico de Estado”. Pero el trabajo social asume también otras funciones, puesto que el costo del sufrimiento social es importante tanto en el plano económico que humano. Los trabajadores sociales invierten esfuerzo en mejorar las condiciones de vida de las personas y de los grupos y en luchar por mayor justicia social. El Trabajo Social enfrenta presiones contradictorias que debe asumir apoyándose en los valores éticos, en la deontología y en sus conocimientos teóricos y prácticos. Puede entonces articular las tres dimensiones del saber, saber hacer y saber ser (savoir, savoir faire, savoir être. La profesionalidad se construye en tensión constante entre las fuerzas internas y externas, entre los elementos de permanencia y los de cambio.

  11. Determinantes sociales de la salud y el trabajo informal

    OpenAIRE

    Consuelo Vélez Álvarez; María del Pilar Escobar Potes; María Eugenia Pico Merchán

    2013-01-01

    Objetivo: Describir elementos teóricos sobre los determinantes sociales de la salud en la población trabajadora informal y condiciones sociales, modos de vida y repercusiones en el proceso salud-enfermedad. Estrategia de búsqueda: Búsqueda sistemática en bases de datos especializadas (Ovid, Proquest, Hinary, Medline, LILACS, Literatura gris). Se utilizaron las siguientes palabras claves: condiciones sociales, factores socioeconómicos, fuerza de trabajo, empleo; de igual forma se retoman texto...

  12. El Periodo de Prueba en los Contratos de Trabajo.

    OpenAIRE

    Asquerino Lamparero, María José

    2017-01-01

    El nacimiento del Derecho del Trabajo está directamente relacionado con la inoperancia de los mecanismos previstos en nuestro Derecho Civil, que parte de un presupuesto en absoluto compartido por la realidad en la que se desenvuelven las relaciones laborales: el principio de autonomía contractual que se sustenta en la igualdad en la que se sitúan las dos partes contractuales.   Esta máxima, la de igualdad, resulta inadecuada para solucionar la tensió...

  13. Mercado de Trabajo. Actividad 3: El Movimiento Laboral Registrado.

    OpenAIRE

    Esteban Yago, Miguel A.; Riquelme Perea, Prudencio José

    2016-01-01

    Vídeos tutoriales para la realización de una actividad relacionada con el mercado de trabajo español: obtención de los datos en una fuente estadística determinada, en este caso, el Movimiento Laboral Registrado del Servicio Público de Empleo Estatal; tratamiento de la información y elaboración de un gráfico de síntesis con una hoja de cálculo.

  14. Male fertility in cystic fibrosis.

    LENUS (Irish Health Repository)

    Chotirmall, S H

    2011-04-05

    Infertility rates among males with cystic fibrosis (CF) approximate 97%. No information is currently available within Ireland determining an understanding of fertility issues and the best methods of information provision to this specialized group. This study aimed to determine understanding and preferred approaches to information provision on fertility issues to Irish CF males. A Descriptive Study utilizing prospective coded questionnaires was mailed to a male CF cohort (n=50). Sections included demographics, fertility knowledge & investigation. Response rate was 16\\/50 (32%). All were aware that CF affected their fertility. More than two-thirds (n=11) were able to provide explanations whilst only one-third (n=5) provided the correct explanation. Significant numbers stated thoughts of marriage and a future family. Half have discussed fertility with a healthcare professional (HCP). Mean age of discussion was 21.9 years. One third preferred an earlier discussion. The commonest first source for information was written material which was also the preferred source. Three-quarters requested further information preferring again, written material. Significant gaps in sex education of Irish CF males exist. Discussion should be initiated by HCPs and centre-directed written material devised to address deficiencies.

  15. Cystic fibrosis: a clinical view.

    Science.gov (United States)

    Castellani, Carlo; Assael, Baroukh M

    2017-01-01

    Cystic fibrosis (CF), a monogenic disease caused by mutations in the CFTR gene on chromosome 7, is complex and greatly variable in clinical expression. Airways, pancreas, male genital system, intestine, liver, bone, and kidney are involved. The lack of CFTR or its impaired function causes fat malabsorption and chronic pulmonary infections leading to bronchiectasis and progressive lung damage. Previously considered lethal in infancy and childhood, CF has now attained median survivals of 50 years of age, mainly thanks to the early diagnosis through neonatal screening, recognition of mild forms, and an aggressive therapeutic attitude. Classical treatment includes pancreatic enzyme replacement, respiratory physiotherapy, mucolitics, and aggressive antibiotic therapy. A significant proportion of patients with severe symptoms still requires lung or, less frequently, liver transplantation. The great number of mutations and their diverse effects on the CFTR protein account only partially for CF clinical variability, and modifier genes have a role in modulating the clinical expression of the disease. Despite the increasing understanding of CFTR functioning, several aspects of CF need still to be clarified, e.g., the worse outcome in females, the risk of malignancies, the pathophysiology, and best treatment of comorbidities, such as CF-related diabetes or CF-related bone disorder. Research is focusing on new drugs restoring CFTR function, some already available and with good clinical impact, others showing promising preliminary results that need to be confirmed in phase III clinical trials.

  16. Growth factors in cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Negar Khalighi

    2016-01-01

    Full Text Available Introduction: Cystic fibrosis is one of the most common autosomal recessive diseases that affects sweat glands and mucosa. CF is a hereditary disease with annual incidence of about 2500 new cases in United Kingdom. Insulin-like growth factor-1 (IGF-1 and insulin-like growth factor binding protein-3 levels decrease in CF. The aim of this study was to assess the role of growth peptides in patients with CF. Method: We searched PubMed, Google scholar, IranMedex, and Scientific Information Database (SID in September 2012 to April 2014. We included clinical studies with available abstracts and full texts that were in English or Persian languages. Manual searching was conducted within the reference lists of articles. Two reviewers independently applied eligibility criteria, assessed quality, and extracted data.Result: The earliest study was published in 1997 and the most recent one was in 2014. Study participants were adults in 3 studies (20% and 12 studies (80% were conducted in children. Patients with CF have lower levels of IGF-1 and there is a significant correlation between IGF-1 levels and growth index in patients with CF.Conclusions: IGF-1 decreases in children with CF and might be the cause of poor growth and low body mass index in these children.

  17. Salud, trabajo e informalidad en el Cauca, Colombia

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    Augusto Muñoz C

    2013-03-01

    Full Text Available Objetivo: describir las condiciones de salud y trabajo de las personas ocupadas en el sector informal del comercio, en cinco municipios del departamento del Cauca, durante el año 2011. Metodología: estudio descriptivo, transversal, desarrollado con 223 sujetos a quienes se les aplicó una encuesta estandarizada a nivel nacional. Resultados: la mayoría (80% de la población está asegurada en salud, pero no a pensiones ni a riesgos profesionales. Más del 70% tiene acceso a telefonía celular, acueducto y energía, pero baja cobertura del servicio de gas y alcantarillado. El 60% manifestó tener una buena salud y más del 50% percibió su lugar de trabajo como un lugar seguro para trabajar. El grupo que mejor se siente con el trabajo que realiza es el de vendedores de leche (92,3%. Discusión: los resultados obtenidos en cuanto al sexo, edad, estado civil y nivel educativo, entre otros, coinciden con los arrojados por un estudio desarrollado a nivel nacional con la misma población. Se encontró que en los municipios incluidos en este estudio no se ha promovido la conformación de Grupos Organizados de Trabajadores Informales, lo cual puede impedir su organización y la mejoría de sus condiciones

  18. Liver Disease in Cystic Fibrosis: an Update

    Science.gov (United States)

    Parisi, Giuseppe Fabio; Di Dio, Giovanna; Franzonello, Chiara; Gennaro, Alessia; Rotolo, Novella; Lionetti, Elena; Leonardi, Salvatore

    2013-01-01

    Context Cystic fibrosis (CF) is the most widespread autosomal recessive genetic disorder that limits life expectation amongst the Caucasian population. As the median survival has increased related to early multidisciplinary intervention, other manifestations of CF have emergedespecially for the broad spectrum of hepatobiliary involvement. The present study reviews the existing literature on liver disease in cystic fibrosis and describes the key issues for an adequate clinical evaluation and management of patients, with a focus on the pathogenetic, clinical and diagnostic-therapeutic aspects of liver disease in CF. Evidence Acquisition A literature search of electronic databases was undertaken for relevant studies published from 1990 about liver disease in cystic fibrosis. The databases searched were: EMBASE, PubMed and Cochrane Library. Results CF is due to mutations in the gene on chromosome 7 that encodes an amino acidic polypeptide named CFTR (cystic fibrosis transmembrane regulator). The hepatic manifestations include particular changes referring to the basic CFTR defect, iatrogenic lesions or consequences of the multisystem disease. Even though hepatobiliary disease is the most common non-pulmonary cause ofmortalityin CF (the third after pulmonary disease and transplant complications), only about the 33%ofCF patients presents clinically significant hepatobiliary disease. Conclusions Liver disease will have a growing impact on survival and quality of life of cystic fibrosis patients because a longer life expectancy and for this it is important its early recognition and a correct clinical management aimed atdelaying the onset of complications. This review could represent an opportunity to encourage researchers to better investigate genotype-phenotype correlation associated with the development of cystic fibrosis liver disease, especially for non-CFTR genetic polymorphisms, and detect predisposed individuals. Therapeutic trials are needed to find strategies of

  19. Atención multidisciplinaria a pacientes con fibrosis quística

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    Tamara Rubio González

    1999-12-01

    Full Text Available Se presentan los resultados del trabajo realizado por el grupo multidisciplinario creado para la atención a los pacientes con fibrosis quística en la provincia de Santiago de Cuba, desde enero de 1993 hasta marzo de 1998. En ese período se registraron en total 20 pacientes diagnosticados por su cuadro clínico y la prueba del sudor, así como la historia familiar de la enfermedad. En todos se realizó estudio molecular, y en 9 de ellos se halló al menos una mutación para el gen de la fibrosis quística. Más de la mitad de los enfermos recibió tratamiento con fisioterapia y en el 50 % se utilizaron enzimas pancreáticas. Se destaca la importancia de la creación de grupos multidisciplinarios para el seguimiento de estos pacientes, lo que influye favorablemente en su evolución.We presented the results of the work performed from January 1993 to March 1998 by a multidisciplinary care team set up to take care of patients with cystic fibrosis in Santiago de Cuba. During this period, 20 patients in all were diagnosed with this disease, taking their clinical pictures, sweat test results and previous familial history into account. All the patients were applied molecular studies and nine of them disclosed at least one cystic fibrosis gene mutation. More than half of the sick received physiotherapeutical treatment and other pancreatic enzime-linked therapy. We underlined the importance of the set-up of these multidisciplinary teams for following these patients up which has a favorable impact on their recovery.

  20. Salud y condiciones de trabajo en trabajadores mayores

    Directory of Open Access Journals (Sweden)

    Elena Ordaz Castillo

    2015-09-01

    Full Text Available Introducción: En los últimos años, la población española ha experimentado un crecimiento acelerado de personas mayores. Las previsiones demográficas a corto-medio plazo describen un importante predominio de trabajadores mayores en el mercado laboral. Objetivos: Identificar las diferencias según dos grupos de edad (55 años en la percepción de las condiciones de trabajo y salud de la población trabajadora española. Metodología: Las diferencias entre los dos grupos de edad se analizaron a partir de indicadores de condiciones de trabajo y de salud pertenecientes a la VII Encuesta Nacional de Condiciones de Trabajo del Instituto de Seguridad e Higiene en el Trabajo (VII_ENCT. El análisis consistió en el cálculo de las prevalencias y la odds ratio cruda-ORc y ajustada por sexo con su correspondiente intervalo del confianza al 95%. Resultados: El grupo de trabajadores más jóvenes presentan más riesgo de exposición a seis de los siete indicadores relacionados con las condiciones de trabajo (ruido, vibraciones, carga física, carga mental, autonomía y motivación. No obstante los trabajadores mayores tienen una peor percepción de su estado de salud (ORa= 2,06 [1,75-2,42] y presentan en mayor medida problemas de salud que si bien les conducen a la visita médica más frecuentemente los relacionan menos con su actividad laboral. Conclusiones: A tenor de los resultados, los trabajadores de 55 años y más refieren tener menos quejas respecto a sus condiciones laborales e incluso se sienten más autónomos y motivados. Es el deterioro físico y mental la principal limitación que encuentran estos trabajadores a la hora de ejercer sus tareas. Sería recomendable establecer políticas de promoción de la salud dentro de las empresas para mejorar los indicadores de salud y promover el envejecimiento activo de la población trabajadora española.

  1. New times for Trabajos de Prehistoria (2010 - 2013

    Directory of Open Access Journals (Sweden)

    Montero Ruíz, Ignacio

    2010-12-01

    Full Text Available The new editorial and advisory boards present their editorial line and policy for the next four-year cycle. We maintain the subject coverage, languages of publications and standards of quality that have brought Trabajos de Prehistoria international recognition. New features include the adoption of the open source software, Open Journal System, as the management system, the suppression of the embargo starting with issue 67(2 2010, and the possibility of publishing monographic issues, as agreed by the Editorial Board, following the criteria of other journals of impact. We update the norms for the presentation of original manuscripts and include a detailed style sheet. We acknowledge the vital contribution of peer reviewers to the current positioning of the Journal as a landmark in its subject coverage within and beyond the Iberian Peninsula. The reviews will now follow a double-blind procedure. We also express our gratitude to those responsible for Electronic Publishing for their assistance and advice in increasing the visibility of Trabajos de Prehistoria.

    El nuevo equipo editorial presenta las líneas generales de su gestión. Se mantiene la temática, lenguas de publicación y estándares de calidad, base del reconocimiento y valoración internacional de Trabajos de Prehistoria. Se introducen novedades como incorporar la gestión de la Revista al programa libre de gestión Open Journal System, suprimir el embargo desde el número 67 (2 2010 y la posibilidad de publicar números monográficos por decisión del Consejo de Redacción, siguiendo el criterio de otras revistas de impacto. Se renuevan las normas para los autores incluyendo una hoja de estilo. Se reconoce el papel esencial jugado por los evaluadores y evaluadoras en la situación actual de referencia alcanzada por la Revista dentro y fuera de la Península Ibérica en su ámbito temático. Su revisión se ajustará ahora al procedimiento doble ciego. Igualmente se agradece a los

  2. [es] Los conocimientos en trabajo social: elogio del eclecticismo

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Deslauriers

    2010-06-01

    Full Text Available La ciencia está en el origen del trabajo social. En efecto, el objetivo que perseguía Mary Richmond al conceptualizar la disciplina de trabajo social consistía en reemplazar las creencias religiosas por un enfoque racional. Así pues, el conocimiento científico se inscribe en el corazón del trabajo social desde el principio. Dicho esto, las grandes teorías son menos útiles en la práctica de una profesión cuya finalidad es ayudar a las personas que viven las situaciones más diversas. Esta es la razón por la cual el trabajo social se construye a partir de una base ecléctica: el trabajador social eficaz toma de un vasto conjunto de nociones, en apariencia dispares, aquellas que mejor se adaptan a la situación. Ahora bien, ¿cómo enseñar este conocimiento práctico a los estudiantes de trabajo social? Este artículo trata de estas cuestiones y propone algunas pistas de reflexión. Science is closely related to social work, from its very origin. In fact, with the conceptualization of social work, Mary Richmond’s objective was to replace religious beliefs by a more rational approach. Thus, right from its beginning, the scientific knowledge was at the core of social work. This being said, grand theories are less appropriate to the practice of social work because this profession deals with persons living in particular situations. That is why social work is built upon an eclectic basis : social worker has to draw from a vast array of notions and theories to borrow bits and pieces which will help to explain and attenuate problem experienced by persons. Now, this practical knowledge can be taught to students in social work? This article deals with these questions and proposes some reflections.

  3. Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models

    Directory of Open Access Journals (Sweden)

    Martorana Piero A

    2005-07-01

    Full Text Available Abstract Background The separation of emphysema from fibrosis is not as clear-cut as it was thought in early studies. These two pathologies may be present at the same time in human lungs and in mice either instilled with elastolytic enzymes or bleomycin or exposed to cigarette-smoke. According to a current view, emphysema originates from a protease/antiprotease imbalance, and a role for antiproteases has also been suggested in the modulation of the fibrotic process. In this study we investigate in experimental animal models of emphysema and fibrosis whether neutrophil elastase may constitute a pathogenic link between these two pathologies. Methods This study was done in two animal models in which emphysema and fibrosis were induced either by bleomycin (BLM or by chronic exposure to cigarette-smoke. In order to assess the protease-dependence of the BLM-induced lesion, a group mice was treated with 4-(2-aminoethyl-benzenesulfonyl fluoride hydrochloride, a serine proteinase inhibitor active toward neutrophil elastase. Lungs from each experimental group were used for the immunohistochemical assessment of transforming growth factor-β (TGF-β and transforming growth factor-α (TGF-α and for determination of the mean linear intercept as well as the percent volume densities of fibrosis and of emphysematous changes. Additionally, the lungs were also assessed for desmosine content and for the determination of elastase levels in the pulmonary interstitium by means of immunoelectron microscopy. Results We demonstrate that in BLM-treated mice (i the development of elastolytic emphysema precedes that of fibrosis; (ii significant amount of elastase in alveolar interstitium is associated with an increased expression of TGF-β and TGF-α; and finally, (iii emphysematous and fibrotic lesions can be significantly attenuated by using a protease inhibitor active against neutrophil elastase. Also, in a strain of mice that develop both emphysema and fibrosis after

  4. Pathogenic aspects and therapeutic avenues of intestinal fibrosis in Crohn's disease.

    Science.gov (United States)

    Zorzi, Francesca; Calabrese, Emma; Monteleone, Giovanni

    2015-12-01

    In Crohn's disease, one of the two major forms of inflammatory bowel diseases in human beings, persistent and chronic inflammation promotes fibrotic processes thereby facilitating formation of strictures, the most common indication for surgical intervention in this disorder. The pathogenesis of Crohn's disease-associated fibrosis is not fully understood, but variants of genes involved in the recognition of microbial components/products [e.g. CARD15 (caspase-activating recruitment domain 15) and ATG16L1 (autophagy-related 16-like 1)] are associated with this phenotype, and experimental evidence suggests that intestinal fibrosis results from an altered balance between deposition of ECM (extracellular matrix) and degradation of ECM by proteases. Studies have also contributed to identify the main phenotypic and functional alterations of cells involved in the fibrogenic process, as well as molecules that stimulate such cells to produce elevated amounts of collagen and other ECM-related proteins. In the present review, we assess the current knowledge about cellular and molecular mediators of intestinal fibrosis and describe results of recent studies aimed at testing the preventive/therapeutic effect of compounds in experimental models of intestinal fibrosis. © 2015 Authors; published by Portland Press Limited.

  5. Chronic hepatitis C and liver fibrosis.

    Science.gov (United States)

    Sebastiani, Giada; Gkouvatsos, Konstantinos; Pantopoulos, Kostas

    2014-08-28

    Chronic infection with hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality worldwide and predisposes to liver fibrosis and end-stage liver complications. Liver fibrosis is the excessive accumulation of extracellular matrix proteins, including collagen, and is considered as a wound healing response to chronic liver injury. Its staging is critical for the management and prognosis of chronic hepatitis C (CHC) patients, whose number is expected to rise over the next decades, posing a major health care challenge. This review provides a brief update on HCV epidemiology, summarizes basic mechanistic concepts of HCV-dependent liver fibrogenesis, and discusses methods for assessment of liver fibrosis that are routinely used in clinical practice. Liver biopsy was until recently considered as the gold standard to diagnose and stage liver fibrosis. However, its invasiveness and drawbacks led to the development of non-invasive methods, which include serum biomarkers, transient elastography and combination algorithms. Clinical studies with CHC patients demonstrated that non-invasive methods are in most cases accurate for diagnosis and for monitoring liver disease complications. Moreover, they have a high prognostic value and are cost-effective. Non-invasive methods for assessment of liver fibrosis are gradually being incorporated into new guidelines and are becoming standard of care, which significantly reduces the need for liver biopsy.

  6. The Role of Catalase in Pulmonary Fibrosis

    Directory of Open Access Journals (Sweden)

    Takigawa Tomoko

    2010-12-01

    Full Text Available Abstract Background Catalase is preferentially expressed in bronchiolar and alveolar epithelial cells, and acts as an endogenous antioxidant enzyme in normal lungs. We thus postulated epithelial damage would be associated with a functional deficiency of catalase during the development of lung fibrosis. Methods The present study evaluates the expression of catalase mRNA and protein in human interstitial pneumonias and in mouse bleomycin-induced lung injury. We examined the degree of bleomycin-induced inflammation and fibrosis in the mice with lowered catalase activity. Results In humans, catalase was decreased at the levels of activity, protein content and mRNA expression in fibrotic lungs (n = 12 compared to control lungs (n = 10. Immunohistochemistry revealed a decrease in catalase in bronchiolar epithelium and abnormal re-epithelialization in fibrotic areas. In C57BL/6J mice, catalase activity was suppressed along with downregulation of catalase mRNA in whole lung homogenates after bleomycin administration. In acatalasemic mice, neutrophilic inflammation was prolonged until 14 days, and there was a higher degree of lung fibrosis in association with a higher level of transforming growth factor-β expression and total collagen content following bleomycin treatment compared to wild-type mice. Conclusions Taken together, these findings demonstrate diminished catalase expression and activity in human pulmonary fibrosis and suggest the protective role of catalase against bleomycin-induced inflammation and subsequent fibrosis.

  7. Formación de jóvenes para el trabajo: escolaridad, capacitación y trabajo infantil

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    Ibarrola María de

    2003-01-01

    Full Text Available El estudio al cual se refiere este artículo es parte de um projecto amplio de investigación realizado con en el proposito de analizar la formación de los jóvenes para el trabajo en una ciudad mexicana, que se orientó a conocer las múltiples maneras como esta se resuelve. En ese sentido fueron abordadas las politicas públicas y privadas que impulsan la formación para el trabajo juvenil, las instituciones y sistemas de educación que intervienen y los actores envolucrados. El ojetivo de este artículo es describir y analizar especificamente las tres vias de formación en la industria del calzado: la escolaridad, la capacitación intencional impartida en el interior de la empresa y los conocimientos y competencias adquiridos por los trabajadores a través de sus experiencias más o menos intencionales, en los diversos centros de trabajo. Se proponen finalmente algunos puntos básicos de debate al respecto.

  8. EL TRABAJO, AL LECTOR: NUEVAS FORMAS DE REPRESENTACIÓN DEL PODER EN TRABAJOS DEL REINO DE YURI HERRERA

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    Sara Carini

    2012-07-01

    Full Text Available Resumen: El artículo se propone como un punto de partida en la investigación de las nuevas formas de representación del poder en la literatura hispanoamericana contemporánea. En este trabajo llevaremos adelante un primer análisis de la novela Trabajos del reino de Yuri Herrera para identificar una posible continuidad con la representación del poder que caracterizó la nueva novela histórica e identificar los recursos que vinculan el lector en la interpretación de los hechos. Abstract: The article aims to be a starting point in the analysis of the new forms of representing power in contemporary Latin American literature. In this work we will attempt to advance a preliminary analysis of the novel Trabajos del reino by Yuri Herrera with the aim of identifying a possible continuity with the forms of representing power in the nueva novela histórica in order to underline the figures of speech that connect the reader to the interpretation of facts in the contemporary novel.

  9. Fibrosis miocárdica

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    Adolfo Francisco de

    1959-09-01

    Full Text Available Se hace una revisión de la fibroelastosis endocárdica anotando la confusión en la denominación que existe actualmente. Se enumeran los diferentes factores que hasta ahora se han encontrado como causantes del cuadro y las distintas teorías que tratan de explicar su patogenia. Se hace la descripción del cuadro clínico y se presenta un caso de un hombre de treinta años que ingresó al Hospital de San Juan de' Dios por una afasia principalmente de expresión y un cuadro clínico de insuficiencia cardíaca de origen obscuro. Se sospechó el diagnóstico de Fibrosis miocárdica por la clínica, el  E. C. G. y los rayos X. Posteriormente estuvieron de acuerdo con este diagnóstico los datos hemodinámicos y e! hecho de que durante la 'toma de una biopsia de pulmón se produjera paro cardíaco, que hizo necesario el masaje cardíaco, encontrando un corazón enormemente aumentado de tamaño, que presentaba una placa de color blanco de 11/2 centímetros localizada sobre e! epicardio de! Ventrículo izquierdo. Al examen microscópico se observó que esta placa estaba formada por tejido conjuntivo fibroso laxo. Se discute el diagnóstico y se pone de presente que el paciente de que se trata está vivo.

  10. New therapeutic target for the non-electrophysiological signaling in atrial fibrosis and fibrillation such as inflammation

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    Naohiko Takahashi

    2012-06-01

    Full Text Available We have experimentally established appropriate models of atrial fibrillation (AF with atrial interstitial fibrosis. Two approaches were adopted. Firstly, left atrial fibrosis was induced by continuous infusion of angiotensin II (AII. In an electrophysiological study using isolated perfused heart, AF was easily induced following AII treatment. Repeated whole-body hyperthermia led to the induction of heat-shock protein 72, which resulted in attenuation of AII-induced left atrial fibrosis and suppression of AF inducibility. Secondly, atrial fibrosis was induced by pressure overload by abdominal aortic constriction (AAC. AAC enhanced left atrial expression of monocyte chemoattractant protein-1 and activity of matrix metalloproteinase-9. Treatment with pioglitazone, a peroxisome proliferator-activated receptor-γ agonist, resulted in attenuation of pressure overload-induced left atrial fibrosis and suppression of AF inducibility. In the same AAC model, the effects of candesartan on gap junction remodeling were investigated. Connexin 43 (Cx43 of the left atria was firmly located in the intercalated disks in control rats. A progressive redistribution of Cx43 from the intercalated disk to the lateral surface (lateralization was observed in AAC rats. Candesartan prevented left Cx43 lateralization. Thus, heat-shock proteins, pioglitazone, and candesartan could be novel therapeutic approaches to prevent atrial fibrosis and AF.

  11. Ketamine induced renal fibrosis in a ketamine addition rat model

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    Mei-Yu Jang

    2017-09-01

    Conclusion: Ketamine treatment not only induced cystitis-like syndrome, but also renal fibrosis. These renal interstitial fibrosis changes may be induced by the TGF-β pathway. These preliminary results can provide valuable information from a clinical perspective.

  12. Cystic Fibrosis-Related Diabetes (CFRD): Daily Management

    Science.gov (United States)

    Cystic Fibrosis-Related Diabetes (CFRD): Daily Management September 20, 2011 This Web cast is supported by an unrestricted ... Moran, MD Professor, Pediatric Endocrinology University of Minnesota Cystic Fibrosis-Related Diabetes (CFRD): Daily Management September 20, 2011 ...

  13. Microbial ecology and adaptation in cystic fibrosis airways

    DEFF Research Database (Denmark)

    Yang, Lei; Jelsbak, Lars; Molin, Søren

    2011-01-01

    Chronic infections in the respiratory tracts of cystic fibrosis (CF) patients are important to investigate, both from medical and from fundamental ecological points of view. Cystic fibrosis respiratory tracts can be described as natural environments harbouring persisting microbial communities...

  14. Rehabilitation with Cystic Fibrosis: From Utopia to Reality.

    Science.gov (United States)

    Goldberg, Richard T.; And Others

    1980-01-01

    The paper dispels some of the myths regarding cystic fibrosis (a genetic metabolism disorder), provides information on the latest developments in rehabilitation, summarizes research in the field, and projects future needs of the patient with cystic fibrosis. (SBH)

  15. Development of Fibrosis in Acute and Longstanding Ulcerative Colitis

    NARCIS (Netherlands)

    de Bruyn, Jessica R.; Meijer, Sybren L.; Wildenberg, Manon E.; Bemelman, Willem A.; van den Brink, Gijs R.; D'Haens, Geert R.

    2015-01-01

    Background: Intestinal fibrosis is a process driven by chronic inflammation leading to increased presence of myofibroblasts and collagen deposition. Although strictures are rarely seen in ulcerative colitis [UC], longstanding disease is believed to cause fibrosis resulting in altered bowel function.

  16. Trabajo como un encuentro: entre lo visible y lo invisible, el desafío de evaluar el trabajo

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    Yves SCHWARTZ

    2012-04-01

    Full Text Available Cómo reconsiderar los modos de gobierno, de gestión, de organización del trabajo en el área de la salud? Esta cuestión se confronta, actualmente, con un gran desafío: el alto grado de desarrollo del conocimiento en áreas como la biología y las tecnologías médicas, las múltiples profesiones relacionadas a la gestión de cuidados, en escala regional y nacional. Tratando de realizar una contribución frente a este desafío, tomamos en cuenta inicialmente algunas dimensiones inherentes a cualquier actividad de trabajo. Frente a un conjunto de normas que anteceden a cualquier acción humana, afirmamos que es imposible y no vivencial que esa acción, dentro de la singularidad de una determinada situación de vida y de trabajo, consista en su mera aplicación. Entre las normas y la acción, siempre se trata, de un encuentro parcial, de un debate de normas, en parte inéditas, de donde advienen inevitablemente elecciones, arbitrajes orientados por nuestra relación con el mundo de valores. Si cualquier trabajo siempre consiste en la forma como se trate este encuentro parcial o en el debate local de normas, cómo podría esta substancia del trabajo ser visible, cuantificable, evaluable en su esencia? En el área de la salud, esta dimensión de encuentro nos parece exacerbada por los múltiples protagonistas pertinentes: encuentros cada vez más (resingularizados entre conocimientos, técnicas profesiones, pacientes, usuarios, grupos sociales. Si un debate de normas siempre es “una dramaturgia del uso de uno mismo”, en el ámbito de los cuidados siempre es, en gran medida, un encuentro de dramaturgias del uso de uno mismo. Basándose en dos observaciones de G.Canguilhem, defendemos la idea de que formas de cooperación innovadoras y creativas, que ya comenzaron a aplicarse en algunos lugares, deben ser colocadas a prueba en gran escala para que integren todas las instrucciones de estos encuentros en la gestión de la salud pública.

  17. Profibrotic potential of Prominin-1+ epithelial progenitor cells in pulmonary fibrosis

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    Lüscher Thomas F

    2011-09-01

    Full Text Available Abstract Background In idiopathic pulmonary fibrosis loss of alveolar epithelium induces inflammation of the pulmonary tissue followed by accumulation of pathogenic myofibroblasts leading eventually to respiratory failures. In animal models inflammatory and resident cells have been demonstrated to contribute to pulmonary fibrosis. Regenerative potential of pulmonary and extra-pulmonary stem and progenitor cells raised the hope for successful treatment option against pulmonary fibrosis. Herein, we addressed the contribution of lung microenvironment and prominin-1+ bone marrow-derived epithelial progenitor cells in the mouse model of bleomycin-induced experimental pulmonary fibrosis. Methods Prominin-1+ bone marrow-derived epithelial progenitors were expanded from adult mouse lungs and differentiated in vitro by cytokines and growth factors. Pulmonary fibrosis was induced in C57Bl/6 mice by intratracheal instillation of bleomycin. Prominin-1+ progenitors were administered intratracheally at different time points after bleomycin challenge. Green fluorescence protein-expressing cells were used for cell tracking. Cell phenotypes were characterized by immunohistochemistry, flow cytometry and quantitative reverse transcription-polymerase chain reaction. Results Prominin-1+ cells expanded from healthy lung represent common progenitors of alveolar type II epithelial cells, myofibroblasts, and macrophages. Administration of prominin-1+ cells 2 hours after bleomycin instillation protects from pulmonary fibrosis, and some of progenitors differentiate into alveolar type II epithelial cells. In contrast, prominin-1+ cells administered at day 7 or 14 lose their protective effects and differentiate into myofibroblasts and macrophages. Bleomycin challenge enhances accumulation of bone marrow-derived prominin-1+ cells within inflamed lung. In contrast to prominin-1+ cells from healthy lung, prominin-1+ precursors isolated from inflamed organ lack regenerative

  18. Fibrocytes in pulmonary fibrosis: a brief synopsis

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    Shyam Maharaj

    2013-12-01

    Full Text Available Fibrocytes are bone marrow-derived, circulating mesenchymal progenitor cells that play a role in several fibrotic disorders, including lung fibrosis. They are attracted to injured tissue by various chemokines. It is likely that fibrocytes play a detrimental role in tissue homeostasis and promote fibrosis, although this paradigm needs further confirmation. This would make fibrocytes a possible novel treatment target for fibrotic disorders. Fibrocytes also have some potential as a biomarker for idiopathic pulmonary fibrosis (IPF and other diseases, but the promising preliminary data from single centre studies still require independent validation. Despite several, as yet, unresolved issues, it has become clear that fibrocytes are more than an incidental finding in lung injury and repair, and may hold great promise for the future of IPF management.

  19. Pharmacological management of cystic fibrosis related diabetes.

    Science.gov (United States)

    Moheet, Amir; Moran, Antoinette

    2018-02-01

    There are limited data from randomized clinical trials to guide optimal options for pharmacological treatment of cystic fibrosis related diabetes (CFRD). Current guidelines recommend insulin as the only treatment option for CFRD. Areas covered: Current guidelines for screening, diagnosis and pharmacological agents for treatment of impaired glucose tolerance and CFRD in patients with cystic fibrosis are reviewed. Insights from clinical studies examining the role of insulin therapy in CFRD are presented. Expert commentary: CFRD is the most common extra pulmonary complication of cystic fibrosis, and is primarily related to insulin insufficiency. Insulin is the treatment of choice for CFRD. Insulin treatment is associated with improvement in glycemic control, nutritional status and lung function. Current data does not support use of oral hypoglycemic agents for treatment of CFRD.

  20. Clinical application of noninvasive diagnosis of liver fibrosis

    OpenAIRE

    ZHU Chuanlong

    2015-01-01

    Hepatic fibrosis is the common outcome of chronic liver diseases of various causes. At present, liver biopsy is the “gold standard” for the diagnosis of liver fibrosis, but it has limitations and is invasive, which leads to the development of noninvasive assessment of liver fibrosis. The article mainly introduces the technology and application of noninvasive diagnosis of liver fibrosis from the aspects of clinical manifestation, serology, and radiology. It has pointed out the clinical value o...

  1. Enteral tube feeding for cystic fibrosis.

    Science.gov (United States)

    Morton, Alison; Wolfe, Susan

    2015-04-09

    Enteral tube feeding is routinely used in many cystic fibrosis centres when oral dietary and supplement intake has failed to achieve an adequate nutritional status. The use of this method of feeding is assessed on an individual basis taking into consideration the patients age and clinical status. To examine the evidence that in people with cystic fibrosis, supplemental enteral tube feeding improves nutritional status, respiratory function, and quality of life without significant adverse effects. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. We also contacted the companies that market enteral feeds and reviewed their databases.Date of the most recent search of the Group's Cystic Fibrosis Trials Register: 13 February 2015.Date of the most recent hand search of PubMed and conference abstract books: 13 February 2015. All randomised controlled trials comparing supplemental enteral tube feeding for one month or longer with no specific intervention in people with cystic fibrosis. The searches identified 38 trials; however, none were eligible for inclusion in this review. There are no trials included in this review. Supplemental enteral tube feeding is widely used throughout the world to improve nutritional status in people with cystic fibrosis. The methods mostly used, nasogastric or gastrostomy feeding, are expensive and may have a negative effect on self-esteem and body image. Reported use of enteral tube feeding suggests that it results in nutritional and respiratory improvement; but, efficacy has not been fully assessed by randomised controlled trials. It is acknowledged, however, that performing a randomised controlled trial would be difficult due to the ethics of withholding an intervention in a group of patients whose nutritional status necessitates it.

  2. Un caso de insomnio por cambio de turno de trabajo

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    Ihab Zubeidat

    2003-01-01

    Full Text Available Un hombre de profesión militar acude a consulta con el fin de recibir ayuda a su problema para iniciar y mantener el sueño, después de seguir un tratamiento farmacológico con zolpidem y clorazepato. Los datos de la evaluación indican que los turnos de trabajo eran la causa principal de su problema. Los diarios de sueño muestran una latencia de sueño media de 70 minutos, presentando varios despertares durante la noche, mostrando un sueño inquieto de un tiempo comprendido entre las dos y tres horas y media diarias. También presenta pensamientos ansiosos relativos a su propio sueño y a su trabajo. Por todo ello, el paciente fue diagnosticado de insomnio por alteración del ritmo circadiano, del tipo de turnos de trabajo. Las recomendaciones terapéuticas fueron poner en marcha un programa de intervención cognitivo-conductual con el objetivo de cambiar los pensamientos desagradables y favorecer los estados de relajación del paciente. Los resultados indican una mejoría en la calidad del sueño como consecuencia del aumento de las horas totales de sueño (4:00– 4:30 horas, la reducción de la latencia del sueño a un tiempo aproximado de 30 minutos y el número de despertares a uno ó ninguno.

  3. Determinants of pulmonary fibrosis and lipidosis in the silica model.

    Science.gov (United States)

    Heppleston, A. G.

    1986-01-01

    The conditions which might favour development of the fibrotic or the lipid component of the pulmonary reaction to inhaled quartz were examined in rats. Smaller particle size and freedom from surface contamination by amorphous silica or iron oxide, status of the animals whether specific pathogen-free or conventional, and the resistance of cell membranes to damage appeared to bear on fibrogenesis. Increased membrane stability by treatment with polyvinylpyridine-N-oxide abolished not only the fibrosis but also the response of type II cells and hence lipidosis. The rate and intensity of quartz deposition may also affect the response, a low concentration inhaled over a long period favouring nodulation. No other manipulations, environmental or pharmacological, succeeded in inhibiting lipidosis to the benefit of fibrosis. Guinea pigs, however, behaved differently, their reaction being characterized by massive alveolar accumulation of dust-bearing macrophages and type II cell hyperplasia but not by lipidosis. The species variation is unexplained but macrophage predominance may represent a phase that later transforms to lipidosis. The experimental findings may have implications for forms of pneumoconiosis other than silicosis. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 PMID:3026427

  4. Reconocimiento jurídico y social del trabajo penoso

    OpenAIRE

    Haase de Miranda, Anelise

    2016-01-01

    En la obra Trabajadores, el fotógrafo brasileño Sebastião Salgado, expone 350 fotos de actividades que él mismo ha calificado de "trabajo duro y penoso ". Se trata de una categoría ya olvidada o, al menos, se aborda de forma insuficiente en el derecho laboral. Este desequilibrio cuantitativo existente entre lo que el artista retrató como actividades en condiciones de penosidad, el respectivo tratamiento teórico , la praxis y las legislaciones jurídico-laborales, hace que nos planteemos las ra...

  5. Organizaciones para el siglo XXI: grupos de trabajo autogestionados.

    Directory of Open Access Journals (Sweden)

    Luis Avendaño Fernández

    2013-11-01

    Full Text Available En la actualidad, muchas empresas exitosas están dejando atrás los esquemas rígidos y autoritarios de organización y orientan sus esfuerzos hacia la formación de equipos autogestionados que integran el logro de los objetivos de eficiencia, rentabilidad y crecimiento que requiere la empresa, con el logro de los objetivos individuales y grupales de desarrollo humano. En Colombia las OTAS (Organizaciones de Trabajo Asociado poseen características de grupos autodirigidos que la empresa debe conocer y adoptar con el fin de conservar su participación en el mercado.

  6. Siendo una m??s: trabajo de campo e intimidad

    OpenAIRE

    Alc??zar-Campos, Ana

    2014-01-01

    El trabajo de campo ocupa un lugar central en la trayectoria de cualquier antrop??logo. ??ste implica una estancia prolongada en el campo, manteniendo relaciones significativas y continuadas con quienes denominamos informantes y/o interlocutores.[1] En este contexto, nuestra implicaci??n afectiva (y sexual) no deber??a sorprender; no obstante, se ha establecido una especie de tab?? en torno a esta cuesti??n (Kulick y Willson 1995; Newton 1993). As??, este art??culo se sit??a, a trav??s de la ...

  7. Entre la vida cotidiana y las transformaciones del trabajo

    OpenAIRE

    Martin, Antonio

    1999-01-01

    El artículo presenta la línea de investigación del Grupo de Esatudios sobre Trabajo y Vida cotidiana, en su contenido, proyección política y metodología pluridimensional. Se presentan algunos objetivos prioritarios de las investigaciones llevadas a cabo, tanto sus aspectos teóricos y metodológico-técnicos, como sus resultados. (Redacción). The article shows the research done by the Study Group on Labour and Everiday life, the content, political endeavour and pluridimensional methodology. S...

  8. Flexibilidad del trabajo: discurso y construcción social

    OpenAIRE

    Enrique de la Garza Toledo

    2000-01-01

    A lo largo de este artículo se presentan diversas teorías y experiencias de flexibilidad laboral en México. El texto se inicia con un resumen de las principales teorías y argumentos discursivos sobre la flexibilización del trabajo en América Latina. Posteriormente se analiza el caso mexicano y sus distintas etapas: 1) de 1980 a 1992, caracterizada por una flexibilización unilateral y el inicio de un nuevo modelo económico; 2) de 1992 a 1994, en que se busca construir una nueva flexibilidad co...

  9. Accidentes de trabajo en un hospital de agudos

    Directory of Open Access Journals (Sweden)

    Pérez Bermúdez B.

    1998-01-01

    Full Text Available FUNDAMENTO: El mejor conocimiento de los determinantes y circunstancias de producción de los accidentes laborales, favorecerá la implantación de medidas correctoras. El objetivo de este trabajo es describir la evolución temporal de los accidentes de trabajo (AT y determinar los factores de riesgo de baja médica en el Hospital Dr. Peset de Valencia. MÉTODOS: Descripción y análisis retrospectivo de los accidentes de trabajo producidos en el Hospital Dr. Peset de Valencia durante los años 1992 a 1995. Se estimó por métodos deterministas la tendencia y estacionalidad de las series (índices estacionales, IE. Se aplicó un modelo de regresión logística para identificar los factores pronósticos de baja médica y determinar su probabilidad de ocurrencia . RESULTADOS: Las tasas más elevadas de AT se produjeron entre los trabajadores de cocina y lavandería (10,00 AT por 100 trabajadores-año. Los AT con baja médica mantienen una tendencia cercana a cero siendo febrero el mes con I.E más elevado (IE=139,8. Los que cursan sin baja médica tienen una tendencia positiva (r²=0,23, p<0,0001, siendo mayo el mes de mayor siniestralidad (IE=134,2. La probabilidad de que el accidente curse con baja médica aumenta significativamente con la edad, cuando se produce por la tarde, si ha tenido lugar en cocina/lavandería, y si se trata de un esguince o tendinitis. CONCLUSIONES: la actuación sobre la siniestralidad en los AT que cursen con IT, debería centrarse sobre los trabajos menos cualificados y en las áreas de cocina y lavandería.

  10. Resúmenes de los trabajos sobre las Enfermedades Neuromusculares

    OpenAIRE

    Congreso Nacional de Neurología

    2010-01-01

    Las enfermedades neuromusculares constituyen un conjunto de afectaciones que afectan las neuronas motoras periférica, las vías motoras eferentes o los efectores (músculos esqueléticos). Sus manifestaciones clínicas son muy variadas y dependen de la causa y de los niveles de afectación. En este acápite se pueden encontrar los resúmenes de trabajos relacionados con el síndrome de Guillain Barre, polineuropatía diabética, Atrofia Muscular Espinal, Distrofia miotónica y otros todos presentados en...

  11. Trabajo infantil y problemas del comportamiento en menores trabajadores

    OpenAIRE

    Cardenas Ramirez, Luz Stella

    2016-01-01

    Objetivo: Identificar la relación de los factores de riesgo ocupacional del trabajo infantil con los problemas de comportamiento en menores de edad trabajadores de una plaza de mercado en Colombia Materiales y métodos: Se realizó un estudio de corte transversal con 100 niños trabajadores de la plaza de Mercaneiva. Se aplicó un cuestionario para evaluar los factores ocupacionales en la población, evaluando aspectos sociodemográficos y condiciones laborales; para establecer la prevalencia d...

  12. Effect of Green Tea Extract Encapsulated Into Chitosan Nanoparticles on Hepatic Fibrosis Collagen Fibers Assessed by Atomic Force Microscopy in Rat Hepatic Fibrosis Model.

    Science.gov (United States)

    Safer, Abdel-Majeed A; Hanafy, Nomany A; Bharali, Dhruba J; Cui, Huadong; Mousa, Shaker A

    2015-09-01

    The present study examined the effect of Green Tea Extract (GTE) encapsulated into Chitosan Nanoparticles (CS-NPs) on hepatic fibrosis in rat model as determined by atomic force microscopy (AFM). The bioactive compounds in GTE encapsulated into CS-NPs were determined using LC-MS/MS method. Additionally, the uptake of GTE-CS NPs in HepG2 cells showed enhanced uptake. In experimental fibrosis model, AFM was used as a high resolution microscopic tool to investigate collagen fibers as an indicator of hepatic fibrosis induced by treatment with CCl4. Paraffin sections of fibrotic liver tissues caused by CC4 treatment of rats and the effect of GTE-CS NPs treatment with or without CCl4 on hepatic fibrosis were examined. Liver tissues from the different groups of animals were de-waxed and processed as for normal H/E staining and Masson's trichrome staining to locate the proper area of ECM collagen in the CCl4 group versus collagen in liver tissues treated with the GTE-CS NPs with or without CCl4. Selected areas of paraffin sections were trimmed off and fixed flat on top of mica and inserted in the AFM stage. H/E staining, Masson's trichrome stained slides, and AFM images revealed that collagen fibers of 250 to 300 nm widths were abundant in the fibrotic liver samples while those of GTE-CS NPs were clear as in the control group. Data confirmed the hypothesis that GTE-CS NPs are effective in removing all the extracellular collagen caused by CCl4 in the hepatic fibrosis rat liver.

  13. Endocytosis and intracellular protein degradation in cystic fibrosis fibroblasts

    International Nuclear Information System (INIS)

    Jessup, W.; Dean, R.T.

    1983-01-01

    Normal rates of pinocytosis of [ 3 H]sucrose were measured in cystic fibrosis fibroblasts, and were not affected by the addition of cystic fibrosis serum. Bulk protein degradation (a significant proportion of which occurs intralysosomally following autophagy) and its regulation by growth state were apparently identical in normal and cystic fibrosis cultures. (Auth.)

  14. Living with Cystic Fibrosis: A Guide for the Young Adult.

    Science.gov (United States)

    Cystic Fibrosis Foundation, Atlanta, GA.

    Intended for the young adult with cystic fibrosis, the booklet provides information on dealing with problems and on advances in treatment and detection related to the disease. Addressed are the following topics: description of cystic fibrosis; inheritance of cystic fibrosis; early diagnosis; friends, careers, and other matters; treatment;…

  15. 78 FR 26681 - Medical Criteria for Evaluating Cystic Fibrosis

    Science.gov (United States)

    2013-05-07

    ... Evaluating Cystic Fibrosis AGENCY: Social Security Administration. ACTION: Notice of teleconference. SUMMARY... FR 7968). We use Listings 3.04 and 103.04 to evaluate claims involving cystic fibrosis in adults and... individuals with cystic fibrosis who apply for Social Security disability benefits, and for individuals with...

  16. Doxycycline Attenuated Pulmonary Fibrosis Induced by Bleomycin in Mice

    OpenAIRE

    Fujita, Masaki; Ye, Qing; Ouchi, Hiroshi; Harada, Eiji; Inoshima, Ichiro; Kuwano, Kazuyoshi; Nakanishi, Yoichi

    2006-01-01

    The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

  17. The Role of PPARs in Lung Fibrosis

    Directory of Open Access Journals (Sweden)

    Heather F. Lakatos

    2007-01-01

    wound healing. PPARβ/δ agonists inhibit lung fibroblast proliferation and enhance the antifibrotic properties of PPARγ agonists. PPARγ ligands oppose the profibrotic effect of TGF-β, which induces differentiation of fibroblasts to myofibroblasts, a critical effector cell in fibrosis. PPARγ ligands, including the thiazolidinedione class of antidiabetic drugs, effectively inhibit lung fibrosis in vitro and in animal models. The clinical availability of potent and selective PPARα and PPARγ agonists should facilitate rapid development of successful treatment strategies based on current and ongoing research.

  18. The cystic fibrosis of exocrine pancreas

    DEFF Research Database (Denmark)

    Wilschanski, Michael; Novak, Ivana

    2013-01-01

    The cystic fibrosis transmembrane conductance regulator (CFTR) protein is highly expressed in the pancreatic duct epithelia and permits anions and water to enter the ductal lumen. This results in an increased volume of alkaline fluid allowing the highly concentrated proteins secreted by the acinar...... cells to remain in a soluble state. This work will expound on the pathophysiology and pathology caused by the malfunctioning CFTR protein with special reference to ion transport and acid-base abnormalities both in humans and animal models. We will also discuss the relationship between cystic fibrosis...

  19. Retroperitoneal fibrosis with normal intravenous urogram.

    Science.gov (United States)

    Creagh, F. M.; Stone, T.; Stephenson, T. P.; Lazarus, J. H.

    1985-01-01

    A 58 year old male presented with a two week history of low back pain and malaise. The intravenous urogram (IVU) at presentation was normal but within three months he had developed renal failure with bilateral ureteric obstruction on repeat IVU. Primary retroperitoneal fibrosis was confirmed at operation. This case demonstrates that retroperitoneal fibrosis may progress rapidly to renal failure within a few months of the first symptoms. In addition, the IVU may be normal in the early stages of the illness. Images Figure 1 Figure 2 PMID:3983053

  20. Diagnosis of Adult Patients with Cystic Fibrosis.

    Science.gov (United States)

    Nick, Jerry A; Nichols, David P

    2016-03-01

    The diagnosis of cystic fibrosis (CF) is being made with increasing frequency in adults. Patients with CF diagnosed in adulthood typically present with respiratory complaints, and often have recurrent or chronic airway infection. At the time of initial presentation individuals may appear to have clinical manifestation limited to a single organ, but with subclinical involvement of the respiratory tract. Adult-diagnosed patients have a good response to CF center care, and newly available cystic fibrosis transmembrane receptor-modulating therapies are promising for the treatment of residual function mutation, thus increasing the importance of the diagnosis in adults with unexplained bronchiectasis. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. The diagnosis of cystic fibrosis.

    Science.gov (United States)

    De Boeck, Kris; Vermeulen, Francois; Dupont, Lieven

    2017-06-01

    Establishing the diagnosis of cystic fibrosis (CF) is straight forward in the majority of patients: they present with a clear clinical picture (most frequently chronic respiratory symptoms plus malabsorption), the sweat chloride value is>60mmol/L and two known disease causing CFTR mutations are identified. In less than 5% of subjects, mainly those with a milder or limited phenotype, the diagnostic process is more complex, because initial diagnostic test results are inconclusive: sweat chloride concentration in the intermediate range, less than 2 CF causing mutations identified or both. These patients should be referred to expert centers where bioassays of CFTR function like nasal potential difference measurement or intestinal current measurement can be done. Still, in some patients, despite symptoms compatible with CF and some indication of CFTR dysfunction (e.g. only intermediate sweat chloride value), diagnostic criteria are not met (e.g. only 1 CFTR mutation identified). For these subjects, the term CFTR related disorder (CFTR-RD) is used. Patients with disseminated bronchiectasis, congenital bilateral absence of the vas deferens and acute or recurrent pancreatitis may fall in this category. CF has a very wide disease spectrum and increasingly the diagnosis is being made during adult life, mainly in subjects with milder phenotypes. In many countries, nationwide CF newborn screening (NBS) has been introduced. In screen positive babies, the diagnosis of CF must be confirmed by a sweat test demonstrating a sweat chloride concentration above 60mmol/L. To achieve the benefit of NBS, every baby in whom the diagnosis of CF is confirmed must receive immediate follow-up and treatment in a CF reference center. CF NBS is not full proof: some diagnoses will be missed and in some babies the diagnosis cannot be confirmed nor ruled out with certainty. Screening algorithms that include gene sequencing will detect a high number of such babies that are screen positive with an

  2. La "pirámide de afinación": aplicación práctica y validación experimental de un protocolo de trabajo en el contexto del sistema público de Enseñanzas Superiores Artísticas de Andalucía para la formación de profesorado en la especialidad de violín

    OpenAIRE

    Gallardo Lorenzo, Luis Rubén

    2011-01-01

    Ante un marco educativo que ha variado sensiblemente su diseño en las últimas décadas, la metodología clásica para la formación de profesorado de música en especialidades instrumentales ha quedado, en ciertos aspectos, descontextualizada, mermando parte de su funcionalidad práctica. La sociedad y el modelo de enseñanzas superiores al que debe aplicarse en la actualidad dista notablemente de los parámetros que han originado históricamente los procesos específicos de trabajo y las líneas metodo...

  3. TRABAJO Y CUERPO. EL CASO DE LOS HOMBRES ENFERMEROS

    Directory of Open Access Journals (Sweden)

    ALFONSO HERNÁNDEZ RODRÍGUEZ

    2011-01-01

    Full Text Available La división sexual del trabajo establece espacios y afecta de diferente manera a hombres y mujeres, orienta papeles, permea la elección de carrera, etcétera, marcando la actividad de unos y otras como una extensión de los roles de género. Aquí se indaga, desde la perspectiva de género, si los hombres tienen desventajas o ventajas al laborar en un empleo considerado tradicionalmente "femenino", la segregación sexual en el trabajo y la carga simbólica que tienen el cuerpo y la masculinidad como un privilegio, resultado del llamado "dividendo patriarcal". En el caso de los enfermeros, al ocupar un espacio sexuado que "no les corresponde", enfrentan sanciones sociales, según el régimen de género establecido; pero, el hecho de ser varones también los privilegia por encima de esa sanción social.

  4. Mujer, trabajo y persistencia del maíz

    Directory of Open Access Journals (Sweden)

    Erika Román Montes de Oca

    2013-01-01

    Full Text Available El presente artículo se elaboró con la intención de destacar el lugar que ocupan las mujeres en la sociedad de Amatlán de Quetzalcóatl, tomando para ello como punto principal el trabajo que realizan y el papel que cumplen en la unidad familiar al incidir en la permanencia del maíz en la comunidad y en la trasmisión de los valores para dicha persistencia. Se encontró que a pesar de prevalecer una familia con estructura patriarcal en el seno familiar, la mujer ocupa un lugar de respeto y unión, aportando opiniones y decisiones que son valoradas. También se vislumbran factores de cambio en la comunidad y en la actividad de las mujeres hacia ámbitos extra domésticos. Para este trabajo se realizaron 95 encuestas a nivel de la unidad familiar y diez entrevistas a profundidad.

  5. UNA EXPERIENCIA DE TRABAJO EN GRUPO EN LA DOCENCIA UNIVERSITARIA

    Directory of Open Access Journals (Sweden)

    Nélida Lamelas Castellanos

    2014-08-01

    Full Text Available En estas páginas reflexionamos sobre la importancia del trabajo en grupo en la docencia universitaria y comentamos una experiencia de su aplicación en clases interactivas de la materia Política Económica I perteneciente al Grado de Economía en la Universidad de Santiago de Compostela, España. Presentamos una descripción de la metodología desarrollada en esta actividad y las opiniones de la profesora y el alumnado que ponen de manifiesto el alto grado de satisfacción con su utilización.PALABRAS CLAVE: trabajo en grupo; docencia universitaria; experiencia educativaAN EXPERIENCE OF WORK IN GROUP IN HIGHER EDUCATION TEACHING PROCESSABSTRACTIn these pages we meditate about the importance of the work in group in the higher education teaching process and we comment an experience of their application in interactive classes of the matter Economic Political I belonging to the Grade of Economy in the University of Santiago of Compostela, Spain. We present a description of the methodology developed in this activity and the teacher's opinions and the pupil that show the high grade of satisfaction with their use. KEYWORDS: work in group; higher education teaching process; educational experience

  6. Compromiso laboral del trabajo social en el sector salud

    Directory of Open Access Journals (Sweden)

    Javier Carreón Guillén

    2015-01-01

    Full Text Available En virtud de que el trabajo social está inmerso en políticas públicas y programas sociales que van dirigidos a grupos vulnerables, marginados o excluidos, es menester analizar su compromiso considerando su relación con la gestión para el tratamiento de enfermedades y la rehabilitación en instituciones del sector salud. En tal sentido, el objetivo del presente estudio fue establecer la confiabilidad y validez de un instrumento que mide el compromiso laboral en el sector salud. Para tal propósito, se utilizó una muestra no probabilística de 125 profesionales del trabajo social con experiencia en implementación de programas sociales y seguimiento de estrategias institucionales para la promoción de la salud. Se establecieron la normalidad, confiabilidad y validez de la escala que midió el compromiso laboral; además de un modelo estructural reflejante en el que el compromiso hacia la institución se relacionó positivamente con el compromiso laboral. Los índices de ajuste y residual corroboraron la hipótesis de multidimensionalidad del compromiso laboral.

  7. El mundo del trabajo: viejos y nuevos paradigmas

    Directory of Open Access Journals (Sweden)

    Miguel Suárez Bosa

    2013-11-01

    Full Text Available Con esta comunicación se pretenden dar una visión de las corrientes actuales del estudio histórico sobre los trabajadores. Metodológicamente, se parte de precisar cuál es el objeto de estudio. y de hacer una crítica de las tendencias que se han seguido. Luego, nos centramos en las aportaciones de dos de las ramas que más contribuyen al conocimiento del mundo del trabajo: el movimiento obrero y de las relaciones laborales. Una propuesta de agenda de investigación, fundamentada en la visión global de la historia, con un riguroso tratamiento de las fuentes, técnicas renovadas y una adecuada selección objetivos, completa el trabajo.The intention of this paper is to give a perspective of present movements in historic study about workmen. Methodologically, we start trying to precise which is the subject o f study of the area, and to criticise its tendencies up to now. Next we will study the contributions of the two branches which have most contributed to the study «f working world: the workers movement and labour relations. A proposal of investigation agenda based upon a global vision of history with a strict treatment of sources, renewed techniques and an accurate selection of the objectives that complete the papers.

  8. ANÁLISIS INTRODUCTORIO AL MERCADO DUAL DE TRABAJO

    Directory of Open Access Journals (Sweden)

    Julio Cesar Riascos

    2007-07-01

    Full Text Available En el artículo se examina el fenómeno de la informalidad a la luz del modelo dual del mercado de trabajo. Con ese objetivo, se ilustra al lector, cómo a partir de la dinámica suscitada en el sector formal de la economía laboral, se desprenden efectos simultáneos en la plataforma informal de trabajo. En particular, se estudia el impacto de un incremento en los salarios reales, ambos casos a través de una externalidad originada en acciones de política económica gubernamental; a juzgar por sus efectos, se conviene la existencia de un estrecho vínculo entre las dos partes a través de sus interacciones; en ese mismo sentido, se reconoce la trascendencia del mercado informal en el sostenimiento de la tesis neoclásica de pleno empleo y, se advierte como tarea indispensable la redefinición del concepto de formalidad y subempleo, dadas por supuesto sus implicaciones, esta última parte posibilita estructurar una crítica social al modelo.

  9. El trabajo migratorio de indocumentados en México

    Directory of Open Access Journals (Sweden)

    María de Lourdes González Chávez

    2009-01-01

    Full Text Available Este artículo analiza las antinomias legales entre la Ley general de población y la Ley federal del trabajo en perjuicio de los inmigrantes que, por alguna razón, trabajan en México sin autorización legal para hacerlo. Para ello, se estudian los antecedentes de las leyes federales invocadas, la política del Estado mexicano ante los trabajadores ilegales y su posición oficial contradictoria, al reconocer internacionalmente el trabajo como un derecho inherente al hombre, violentándolo al aplicar las leyes nacionales. Finalmente se pretende ver, en la aplicación del artículo 67 de la ley de población citada, una violación de derechos laborales de los trabajadores que, no obstante tener una condición ilegal de inmigrantes, realizan en México una actividad productiva legal y lícita.

  10. The vitamin E reduces liver lipoperoxidation and fibrosis in a model of nonalcoholic steatohepatitis A vitamina E reduz a lipoperoxidação hepática e a fibrose em modelo experimental de esteatohepatite não-alcoólica

    Directory of Open Access Journals (Sweden)

    Idilio Zamin Jr

    2010-03-01

    Full Text Available CONTEXT: No effective treatment is available for nonalcoholic steatohepatitis in nowadays. OBJECTIVES: To develop a model of nonalcoholic steatohepatitis induced by a methionine and choline deficient diet, as well as to evaluate the role of metformin, vitamin E and simvastatin in the nonalcoholic steatohepatitis progression. METHODS: The study analyzed prospectively 50 Wistar rats for a 90-day period and divided them into five groups of 10 rats. One group was given standard rat diet and the others received the methionine and choline deficient diet. Among the four groups that received this diet, one received saline 0,9% and the others received metformin, vitamin E or simvastatin. After the study period, the animals were sacrificed and their blood was collected for biochemical analysis. The livers were removed for lipoperoxidation analysis and for the histological examinations. RESULTS: The methionine and choline deficient diet was able to induce steatosis in 100% of the animals and nonalcoholic steatohepatitis in 27 (69.2%. The alanine aminotransferase levels were significantly higher in the simvastatin group. The aspartate aminotransferase levels were also higher in the simvastatin group, but were statistically significant only in relation to the standard diet group. When lipoperoxidation values were compared, the groups that received standard rat diet and methionine and choline deficient with vitamin E presented significantly lower rates than the others. The presence of fibrosis was significantly smaller in the group receiving vitamin E. CONCLUSIONS: The diet used was able to induce steatosis and nonalcoholic steatohepatitis. Besides vitamin E showed to reduce the liver oxidative stress, as well as the fibrosis developmentCONTEXTO: Ainda não há um tratamento comprovadamente eficaz para a esteatohepatite não-alcoólica. OBJETIVO: Desenvolver um modelo experimental de esteatohepatite não-alcoólica induzida por dieta deficiente em metionina e

  11. A comparison of the effectiveness of waxed paper and Gore-Tex on the minimally invasive epidural fibrosis model.

    Science.gov (United States)

    Kurt, Gokhan; Celik, Bulent; Cemil, Berker; Doğulu, Fikret; Baykaner, Mustafa Kemali; Ceviker, Necdet

    2009-02-01

    Experimental animal study. The authors conducted a study to determine the effectiveness of waxed paper in preventing postlaminectomy epidural fibrosis in rats. Extensive epidural fibrosis after lumbar surgery may be the underlying cause in most cases of failed back surgery syndrome. Various materials have been used to prevent epidural fibrosis, but only moderate success has been shown. Laminectomies were performed at the fourth lumbar vertebra (L-4) in 30 rats. Waxed paper or Gore-Tex was applied in a blinded fashion to the operative sites. In the control group, only the L-4 laminectomy was performed. The rats were killed 28 days after surgery. The extent of epidural fibrosis was evaluated by histologic analysis. There was a meaningful statistical difference among the waxed paper group and the Gore-Tex group compared with the control group, but there was no difference when the effectiveness of waxed paper was compared with that of Gore-Tex. In this experimental model, the waxed paper applied locally effectively reduced epidural fibrosis, completely avoided dural adherence, and induced no side effects.

  12. El Derecho del Trabajo y su relación con el Derecho Civil ¿El ocaso de la especialidad del Derecho del Trabajo?

    OpenAIRE

    Cristina Mangarelli

    2010-01-01

    En este trabajo se analizarán las relaciones entre el derecho del trabajo y el civil partiendo de la consideración del derecho del trabajo como derecho especial (y autónomo), que no impide recurrir en forma supletoria al derecho civil para llenar vacíos en la norma laboral.El recurso el derecho civil en caso de lagunas, ha permitido desarrollar y acentuar los particularismos del derecho del trabajo, mediante la creación de figuras laborales basadas en normas civiles, limitar los poderes del e...

  13. Clinical application of noninvasive diagnosis of liver fibrosis

    Directory of Open Access Journals (Sweden)

    ZHU Chuanlong

    2015-03-01

    Full Text Available Hepatic fibrosis is the common outcome of chronic liver diseases of various causes. At present, liver biopsy is the “gold standard” for the diagnosis of liver fibrosis, but it has limitations and is invasive, which leads to the development of noninvasive assessment of liver fibrosis. The article mainly introduces the technology and application of noninvasive diagnosis of liver fibrosis from the aspects of clinical manifestation, serology, and radiology. It has pointed out the clinical value of these noninvasive diagnosis techniques, and it discusses the progress in clinical research and its limitations for noninvasive diagnosis of liver fibrosis.

  14. Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.

    Science.gov (United States)

    Locatelli, Luigi; Cadamuro, Massimiliano; Spirlì, Carlo; Fiorotto, Romina; Lecchi, Silvia; Morell, Carola Maria; Popov, Yury; Scirpo, Roberto; De Matteis, Maria; Amenduni, Mariangela; Pietrobattista, Andrea; Torre, Giuliano; Schuppan, Detlef; Fabris, Luca; Strazzabosco, Mario

    2016-03-01

    Congenital hepatic fibrosis (CHF) is a disease of the biliary epithelium characterized by bile duct changes resembling ductal plate malformations and by progressive peribiliary fibrosis, in the absence of overt necroinflammation. Progressive liver fibrosis leads to portal hypertension and liver failure; however, the mechanisms leading to fibrosis in CHF remain elusive. CHF is caused by mutations in PKHD1, a gene encoding for fibrocystin, a ciliary protein expressed in cholangiocytes. Using a fibrocystin-defective (Pkhd1(del4/del4)) mouse, which is orthologous of CHF, we show that Pkhd1(del4/del4) cholangiocytes are characterized by a β-catenin-dependent secretion of a range of chemokines, including chemokine (C-X-C motif) ligands 1, 10, and 12, which stimulate bone marrow-derived macrophage recruitment. We also show that Pkhd1(del4/del4) cholangiocytes, in turn, respond to proinflammatory cytokines released by macrophages by up-regulating αvβ6 integrin, an activator of latent local transforming growth factor-β1. While the macrophage infiltrate is initially dominated by the M1 phenotype, the profibrogenic M2 phenotype increases with disease progression, along with the number of portal myofibroblasts. Consistent with these findings, clodronate-induced macrophage depletion results in a significant reduction of portal fibrosis and portal hypertension as well as of liver cysts. Fibrosis can be initiated by an epithelial cell dysfunction, leading to low-grade inflammation, macrophage recruitment, and collagen deposition; these findings establish a new paradigm for biliary fibrosis and represent a model to understand the relationship between cell dysfunction, parainflammation, liver fibrosis, and macrophage polarization over time. © 2015 by the American Association for the Study of Liver Diseases.

  15. Prognosis in Cystic Fibrosis: Trends and Predictors

    NARCIS (Netherlands)

    Slieker, M.G.

    2008-01-01

    Cystic fibrosis (CF) is a multisystem disease affecting the digestive system, sweat glands, and the reproductive tract, but progressive lung disease continues to be the major cause of morbidity and mortality. Patients develop chronic infection of the respiratory tract with a characteristic array of

  16. Barriers to adherence in cystic fibrosis

    DEFF Research Database (Denmark)

    Bregnballe, Vibeke; Schiøtz, Peter Oluf

    2012-01-01

    Danish patients with cystic fibrosis aged 14 to 25 years and their parents. Conclusions: The present study showed that the majority of adolescents with CF and their parents experienced barriers to treatment adherence. Patients and parents agreed that the three most common barriers encountered lack...

  17. Cystic fibrosis year in review 2016.

    Science.gov (United States)

    Savant, Adrienne P; McColley, Susanna A

    2017-08-01

    In this article, we highlight cystic fibrosis (CF) research and case reports published in Pediatric Pulmonology during 2016. We also include articles from a variety of journals that are thematically related to these articles, or are of special interest to clinicians. © 2017 Wiley Periodicals, Inc.

  18. Pseudomonas aeruginosa biofilms in cystic fibrosis

    DEFF Research Database (Denmark)

    Høiby, Niels; Ciofu, Oana; Bjarnsholt, Thomas

    2010-01-01

    The persistence of chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) patients is due to biofilm-growing mucoid (alginate-producing) strains. A biofilm is a structured consortium of bacteria, embedded in a self-produced polymer matrix consisting of polysaccharide, protein...

  19. Psychosocial problems in children with cystic fibrosis

    DEFF Research Database (Denmark)

    Bregnballe, V; Thastum, M; Schiøtz, P O

    2007-01-01

    AIM: To compare the well-being of children (7-14 years) with cystic fibrosis (CF) (n = 43) with the well-being of healthy controls (n = 1121). METHODS: The self-report questionnaire Beck Youth Inventories (BYI) was used to study depression, anxiety, anger, disruptive behaviour and self...

  20. Immunoreactive trypsin and neonatalscreening for cystic fibrosis

    International Nuclear Information System (INIS)

    Travert, G.; Laroche, D.; Blandin, C.; Pasquet, C.

    1988-01-01

    Immunoreactive trypsin (IRT) was measured in dried blood spots from 160.822 five-day-old babies as a part of a regionwide neonatal screening program for cystic fibrosis. A second test was performed for 492 babies in whom blood IRT levels were found greater than 900 μg/l; retesting revealed persistent elevation in 55. Sweat testing confirmed cystic fibrosis in 43 babies, but results were normal in 12. During the course of this study, a total of 51 cystic fibrosis babies were identified: 43 by newborn screening, 6 because they had meconium ileus; so, early diagnosis was achieved in 49 cases out of 51. Two newborn babies did not have elevated IRT and they were missed by the screening test. Our results confirm that elevated blood IRT is characteristic of newborn babies with cystic fibrosis and show that this test has an excellent specificity (99.7%) and a good sensitivity (95%) when used as a neonatal screening test [fr

  1. Respiratory bacterial infections in cystic fibrosis

    DEFF Research Database (Denmark)

    Ciofu, Oana; Hansen, Christine R; Høiby, Niels

    2013-01-01

    PURPOSE OF REVIEW: Bacterial respiratory infections are the main cause of morbidity and mortality in patients with cystic fibrosis (CF). Pseudomonas aeruginosa remains the main pathogen in adults, but other Gram-negative bacteria such as Achromobacter xylosoxidans and Stenotrophomonas maltophilia...

  2. Endomyocardial Fibrosis in Northern Nigerian Girl

    African Journals Online (AJOL)

    2015-02-19

    a patient with right ventricular endomyocardial fibrosis. Figure 1: The typical egg on stick appearance. Figure 2: Echocardiograph showing, small sized ventricles with enlarged atria. [Downloaded free from http://www.amhsr.org on Thursday, February 19, 2015, IP: 41.135.175.131] || Click here to download free Android ...

  3. Nutritional assessment in children with cystic fibrosis

    Science.gov (United States)

    Optimal nutrition, including consuming 35–40% of calories (kcal) as fat, is a vital part of the management of cystic fibrosis (CF), and involves accurate assessment of dietary intake. We compared 3 methods of nutritional assessment in 8– to 14-year-old children (n=20) with CF: 1) a 24-h Dietary Reca...

  4. Zinc supplementation in children with cystic fibrosis

    Science.gov (United States)

    Cystic fibrosis (CF) leads to malabsorption of macro- and micronutrients. Symptomatic zinc deficiency has been reported in CF but little is known about zinc homeostasis in children with CF. Zinc supplementation (Zn suppl) is increasingly common in children with CF but it is not without theoretcial r...

  5. Endoplasmic reticulum stress in pulmonary fibrosis.

    Science.gov (United States)

    Burman, Ankita; Tanjore, Harikrishna; Blackwell, Timothy S

    2018-03-19

    Endoplasmic reticulum (ER) stress is associated with development and progression of fibrotic diseases, including idiopathic pulmonary fibrosis (IPF). ER stress was first implicated in the pathogenesis of IPF >15 years ago with the discovery of disease-causing mutations in surfactant protein C, which result in a misfolded gene product in type II alveolar epithelial cells (AECs). ER stress and the unfolded protein response (UPR) have been linked to lung fibrosis through regulation of AEC apoptosis, epithelial-mesenchymal transition, myofibroblast differentiation, and M2 macrophage polarization. Although progress has been made in understanding the causes and consequences of ER stress in IPF and a number of chronic fibrotic disorders, further studies are needed to identify key factors that induce ER stress in important cell types and define critical down-stream processes and effector molecules that mediate ER stress-related phenotypes. This review discusses potential causes of ER stress induction in the lungs and current evidence linking ER stress to fibrosis in the context of individual cell types: AECs, fibroblasts, and macrophages. As our understanding of the relationship between ER stress and lung fibrosis continues to evolve, future studies will examine new strategies to modulate UPR pathways for therapeutic benefit. Copyright © 2017. Published by Elsevier B.V.

  6. The lived experience with idiopathic pulmonary fibrosis

    DEFF Research Database (Denmark)

    Overgaard, Dorthe; Kaldan, Gudrun; Marsaa, Kristoffer

    2016-01-01

    The disease course in idiopathic pulmonary fibrosis (IPF) is variable, but patients experience a progressive decline in lung function and increased symptom burden leading to death. Little is known about the patients' experience and their needs during the disease course or about the burden on family...

  7. Pirfenidone treatment in idiopathic pulmonary fibrosis

    DEFF Research Database (Denmark)

    Salih, Goran Nadir; Shaker, Saher Burhan; Madsen, Helle Dall

    2016-01-01

    BACKGROUND: Pirfenidone was approved by the European Medicines Agency and introduced in most European countries in 2011 for treatment of idiopathic pulmonary fibrosis (IPF). OBJECTIVE: To describe the national Danish experiences of pirfenidone treatment for IPF during 30 months with respect...

  8. MicroRNA mimicry blocks pulmonary fibrosis

    Science.gov (United States)

    Montgomery, Rusty L; Yu, Guoying; Latimer, Paul A; Stack, Christianna; Robinson, Kathryn; Dalby, Christina M; Kaminski, Naftali; van Rooij, Eva

    2014-01-01

    Over the last decade, great enthusiasm has evolved for microRNA (miRNA) therapeutics. Part of the excitement stems from the fact that a miRNA often regulates numerous related mRNAs. As such, modulation of a single miRNA allows for parallel regulation of multiple genes involved in a particular disease. While many studies have shown therapeutic efficacy using miRNA inhibitors, efforts to restore or increase the function of a miRNA have been lagging behind. The miR-29 family has gained a lot of attention for its clear function in tissue fibrosis. This fibroblast-enriched miRNA family is downregulated in fibrotic diseases which induces a coordinate increase of many extracellular matrix genes. Here, we show that intravenous injection of synthetic RNA duplexes can increase miR-29 levels in vivo for several days. Moreover, therapeutic delivery of these miR-29 mimics during bleomycin-induced pulmonary fibrosis restores endogenous miR-29 function whereby decreasing collagen expression and blocking and reversing pulmonary fibrosis. Our data support the feasibility of using miRNA mimics to therapeutically increase miRNAs and indicate miR-29 to be a potent therapeutic miRNA for treating pulmonary fibrosis. PMID:25239947

  9. Nephrogenic systemic fibrosis: history and epidemiology

    DEFF Research Database (Denmark)

    Thomsen, Henrik S

    2009-01-01

    Nephrogenic systemic fibrosis (NSF) is a new disease; the first case was diagnosed in 1997. It took 9 years before an association between NSF and gadolinium-based contrast agents (Gd-CAs) was identified. Gadolinium has several advantages for use in relation to enhanced MRI, but it is also a toxic...

  10. Confluent hepatic fibrosis in monozygotic twins

    International Nuclear Information System (INIS)

    Ooi, C.G.C.; Peh, W.C.G.; Chan, K.L.; Saing Htut; Ngan, H.

    1999-01-01

    The MRI and CT features of confluent hepatic fibrosis (CHF) are reported in two 6-year-old-twins. This is the first case report in children of this little known entity, which may mimic mass lesions, and the first to describe an association of CHF with anti-tuberculous drugs

  11. unusual presentation of idiopathic retroperitoneal fibrosis

    African Journals Online (AJOL)

    2008-05-05

    May 5, 2008 ... retroperitoneal fibrosis. On clinical review he was found to have a left hydrocele that was confirmed on ultrasound. Both testes were normal (figures 6 and 7). the patient thereafter had double J stenting and Jabouleys procedure for the ureteral obstruction and hydrocele respectively. Post operatively he was.

  12. case report endomyocardial fibrosis associated with schistosoma ...

    African Journals Online (AJOL)

    2014-12-01

    Dec 1, 2014 ... CASE REPORT. ENDOMYOCARDIAL FIBROSIS ASSOCIATED WITH SCHISTOSOMA. HAEMATOBIUM INFECTION. J. ASSIMENG1, C. I. SEGBEFIA1, 2 and J. NEEQUAYE1,2. 1Department of Child Health, Korle Bu Teaching Hospital, Accra, Ghana, 2University of Ghana Medical. School, Accra, Ghana.

  13. Serum hyaluronic acid as a marker of hepatic fibrosis

    International Nuclear Information System (INIS)

    Khan, J.A.; Khan, F.A.; Ijaz, A.; Khan, N.A.; Mehmood, T.

    2007-01-01

    To determine the serum hyaluronic acid (HA) levels as biochemical marker of hepatic fibrosis and cirrhosis and correlate it with the degree of hepatic fibrosis and cirrhosis. This study was performed on 100 patients of chronic liver disease whose liver biopsies had been carried out. Fifty healthy controls were also included in the study. Routine liver function tests, hepatitis serology and serum hyaluronic acid levels were carried out on patients and controls. Liver biopsy of 100 patients revealed that 21 were in stage 0 fibrosis, 38 in stage 1 fibrosis, 26 in stage 3 fibrosis and 15 in stage 4 fibrosis. Mean Serum HA (mean +- SD) concentration in patients were 189 +- 98 mg/L vs. 21 +- 10 mg/L of healthy controls. The difference observed was statistically significant (p < 0.001). Patients in stage 4 fibrosis had significantly higher (p <0.001) mean serum HA concentration as compared to other stages of liver fibrosis. Diagnostic accuracy of serum HA at marginally elevated level of 60 mg/L determined the sensitivity 78.4 %, specificity 80.9%, positive predicted value 93.9% and negative predicted value of 50%. Serum HA is a useful non-invasive marker of liver fibrosis. There is a strong positive correlation between serum HA levels and degree of liver fibrosis. The concentration of serum HA rises according to progression of liver fibrosis and levels are highest in patients with liver cirrhosis. (author)

  14. Towards a unified approach in the modeling of fibrosis: A review with research perspectives.

    Science.gov (United States)

    Ben Amar, Martine; Bianca, Carlo

    2016-07-01

    Pathological fibrosis is the result of a failure in the wound healing process. The comprehension and the related modeling of the different mechanisms that trigger fibrosis are a challenge of many researchers that work in the field of medicine and biology. The modern scientific analysis of a phenomenon generally consists of three major approaches: theoretical, experimental, and computational. Different theoretical tools coming from mathematics and physics have been proposed for the modeling of the physiological and pathological fibrosis. However a complete framework is missing and the development of a general theory is required. This review aims at finding a unified approach in the modeling of fibrosis diseases that takes into account the different phenomena occurring at each level: molecular, cellular and tissue. Specifically by means of a critical analysis of the different models that have been proposed in the mathematical, computational and physical biology, from molecular to tissue scales, a multiscale approach is proposed, an approach that has been strongly recommended by top level biologists in the past decades. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. Acute irradiation and muscular fibrosis. Development and characteristics in the pig

    International Nuclear Information System (INIS)

    Lefaix, J.L.; Daburon, F.; Remy, J.

    1989-01-01

    This study was performed in an experimental porcin model of acute local irradiation chosen to simulate human accidents. It enabled to determine the development and the physiopathological characteristics of the fibrous tissue which developed in skeletal muscle. In the first month after irradiation the strong inflammatory reaction initiating the radiation induced fibrosis was characterized by edema as visualized on NMR imaging and by acute phase reactant protein changes, associated with elevations of local and general temperatures in irradiated animals. At the margin of the irradiated tissue, atypical fibroblasts isolated among collagen bundles or bunched in nodullary reinforcement were seen associated with intense capillary neogenesis. Several months after irradiation normal skeletal muscle was replaced by atrophic fibrosis delimited by an inflammatory perifibrotic tissue. The muscular fibrosis was characterized by a high atypical fibroblasts density and by an inflammatory distribution pattern of collagen types I, III, IV, laminin, fibronectin and fibrinogen as visualized by immunohistochemical methods. Biochemical results showed an increase in collagen content and synthesis in fibrotic tissue whereas perifibrotic zone synthesized more non collagenous proteins compared with the normal muscle. The contributions of granulation tissue, cellular mediators and inhibition of muscular regeneration to maintain the atrophic character of the muscular radiation induced fibrosis are discussed [fr

  16. Towards a unified approach in the modeling of fibrosis: A review with research perspectives

    Science.gov (United States)

    Ben Amar, Martine; Bianca, Carlo

    2016-07-01

    Pathological fibrosis is the result of a failure in the wound healing process. The comprehension and the related modeling of the different mechanisms that trigger fibrosis are a challenge of many researchers that work in the field of medicine and biology. The modern scientific analysis of a phenomenon generally consists of three major approaches: theoretical, experimental, and computational. Different theoretical tools coming from mathematics and physics have been proposed for the modeling of the physiological and pathological fibrosis. However a complete framework is missing and the development of a general theory is required. This review aims at finding a unified approach in the modeling of fibrosis diseases that takes into account the different phenomena occurring at each level: molecular, cellular and tissue. Specifically by means of a critical analysis of the different models that have been proposed in the mathematical, computational and physical biology, from molecular to tissue scales, a multiscale approach is proposed, an approach that has been strongly recommended by top level biologists in the past decades.

  17. Blood pressure versus direct mineralocorticoid effects on kidney inflammation and fibrosis in DOCA-salt hypertension.

    Science.gov (United States)

    Klanke, Bernd; Cordasic, Nada; Hartner, Andrea; Schmieder, Roland E; Veelken, Roland; Hilgers, Karl F

    2008-11-01

    We examined the contribution of high blood pressure versus direct mineralocorticoid effects to the progression of kidney inflammation and fibrosis in established experimental deoxycorticosterone-acetate (DOCA)-salt hypertension. Male Sprague-Dawley rats underwent unilateral nephrectomy and received subcutaneous DOCA pellets as well as 1% NaCl for drinking. After 4 weeks of DOCA-salt hypertension, rats were either killed (n = 6), or treated with a non-hypotensive dose of spironolactone (n = 7) or triple therapy (hydrochlorothiazide, reserpine and hydralazine, n = 8) to normalize blood pressure or with vehicle (n = 19) for two further weeks. Mean arterial pressure (MAP) was measured intra-arterially. Glomerulosclerosis, interstitial fibrosis, macrophage infiltration and complement deposition were evaluated on kidney sections. Expression of collagens, chemokines and cytokines was measured by real-time PCR. MAP was elevated in DOCA rats, not affected by spironolactone and normalized by triple therapy. Glomerulosclerosis and interstitial fibrosis of DOCA rats were alleviated by spironolactone and triple therapy. Macrophage infiltration, complement C3 deposition and nitrotyrosine staining in the kidney were significantly reduced by spironolactone as well as triple therapy. The expression of collagens, chemokines, adhesion molecules and profibrotic cytokines in the kidney was elevated in hypertension and decreased by triple therapy but not significantly affected by spironolactone. Direct mineralocorticoid effects as well as high blood pressure per se contribute to inflammation and fibrosis of the kidney. Oxidative stress may mediate the direct mineralocorticoid effects on kidney inflammation.

  18. Endostatin and kidney fibrosis in aging: a case for antagonistic pleiotropy?

    Science.gov (United States)

    Lin, Chi Hua Sarah; Chen, Jun; Ziman, Bruce; Marshall, Shannon; Maizel, Julien; Goligorsky, Michael S

    2014-06-15

    A recurring theme of a host of gerontologic studies conducted in either experimental animals or in humans is related to documenting the functional decline with age. We hypothesize that elevated circulating levels of a powerful antiangiogenic peptide, endostatin, represent one of the potent systemic causes for multiorgan microvascular rarefaction and functional decline due to fibrosis. It is possible that during the life span of an organism there is an accumulation of dormant transformed cells producing antiangiogenic substances (endostatin) that maintain the dormancy of such scattered malignant cells. The proof of this postulate cannot be obtained by physically documenting these scattered cells, and it rests exclusively on the detection of sequelae of shifted pro- and antiangiogenic balance toward the latter. Here we compared circulating levels of endostatin in young and aging mice of two different strains and showed that endostatin levels are elevated in the latter. Renal expression of endostatin increased ~5.6-fold in aging animals. This was associated with microvascular rarefaction and progressive tubulointerstitial fibrosis. In parallel, the levels of sirtuins 1 and 3 were significantly suppressed in aging mice in conjunction with the expression of markers of senescence. Treating young mice with endostatin for 28 days showed delayed recovery of circulation after femoral artery ligation and reduced patency of renal microvasculature but no fibrosis. In conclusion, the findings are consistent with the hypothesis on elevation of endostatin levels and parallel microvascular rarefaction and induction of renal fibrosis in aging mice. Copyright © 2014 the American Physiological Society.

  19. Anti-profibrotic effects of artesunate on bleomycin-induced pulmonary fibrosis in Sprague Dawley rats.

    Science.gov (United States)

    Wang, Changming; Xuan, Xiuping; Yao, Wenmin; Huang, Guojin; Jin, Junfei

    2015-07-01

    The present study aimed to determine whether artesunate has beneficial effects on bleomycin-induced pulmonary fibrosis in rats and to examine the possible mechanisms underlying these effects. All experiments were performed with male Sprague Dawley rats weighing 180-250 g. Animals were randomly divided into four experimental groups that were administered either saline alone, artesunate alone, bleomycin alone or bleomycin + artesunate. Lung histopathology was investigated by hematoxylin and eosin staining and Masson staining. Lung profibrotic molecules were analyzed by reverse transcription polymerase chain reaction, immunoblotting and immunohistochemistry. In rats treated with artesunate, pulmonary fibrosis induced by bleomycin was significantly reduced. Administration of artesunate significantly improved bleomycin-induced morphological alterations. Profibrotic molecules, including transforming growth factor-β1, Smad3, heat shock protein 47, α-smooth muscle actin and collagen type I were also reduced by artesunate. These findings suggest that artesunate improves bleomycin-induced pulmonary fibrosis pathology in rats possibly by inhibiting profibrotic molecules associated with pulmonary fibrosis.

  20. Inteligencia y memoria de trabajo: la relación entre factor g, complejidad cognitiva y capacidad de procesamiento

    Directory of Open Access Journals (Sweden)

    Colom Roberto

    2001-01-01

    Full Text Available La psicologia experimental ha estudiado extensivamente las características de la memoria, mientras que la psicología correlacional ha actualizado las principales propiedades de la inteligencia. El acercamiento entre ambos enfoques se basa en el análisis de las relaciones entre un concepto nuclear de la memoria -- la memoria de trabajo -- y el principal ingrediente del concepto psicométrico de inteligencia -- el factor g. Las evidencias disponibles sugieren que las diferencias individuales en g podrían ser explicadas por los conceptos cognitivos de capacidad y de velocidad asociados a la memoria de trabajo. Esas evidencias sugieren nuevos modos de mejorar la inteligencia -- y, por tanto, los correlatos asociados a ella -- a través del incremento de la capacidad del sistema para procesar información de manera eficiente.

  1. ¿PODEMOS APASIONARNOS POR EL TRABAJO?: UNA REVISIÓN DE LA PASIÓN PARA EL TRABAJO

    Directory of Open Access Journals (Sweden)

    Ana Lisbona Bañuelos

    2016-09-01

    Full Text Available Es posible distinguir entre dos tipos de pasión: la pasión armoniosa y la obsesiva, así el modelo teórico denominado Dualistic Model of Passion (DMP (Vallerand et al., 2003 afirma que las actividades puedes ser internalizadas en la propia identidad a través de dos procesos que se corresponden con estos dos tipos de pasión. El presente trabajo pretende revisar los estudios empíricos que abordan el constructo de pasión en el trabajo. Para ello, se ha realizado una búsqueda bibliográfica en la base de datos PsycINFO. El periodo de búsqueda se centra en los cinco últimos años y se han seleccionado aquellos artículos con diseño empírico y cuantitativo. Se han obtenido un total de 90 registros donde se estudia la pasión en el ámbito laboral. Se observa que la pasión ha sido estudiada como un recurso personal, con respuestas asociadas a la satisfacción, bienestar y desempeño.

  2. Condiciones de trabajo que impactan en la vida laboral

    Directory of Open Access Journals (Sweden)

    Laura Martínez Buelvas

    2013-01-01

    Full Text Available Objetivo:Proponer un esquema de clasificación conceptual (ECC basado en el método de análisis de contenidos, con el fin determinar brechas en el conocimiento en cuanto a las variables de condiciones de trabajo que impactan la Calidad de Vida Laboral. Materiales y métodos: Seutilizó una metodología integral de clasificación que considera 54 artículos científicos comprendidos en el periodo 1992 - 2012, a partir de los cuales se estructuraron diferentes categorías, tales como: año de publicación del artículo, titulo de la revista científica en la cual se publicó y un esquema conceptual basado en preguntas. Resultados:Las investigaciones relacionadas con el tema de estudio han aumentado en la última década. El total de artículos revisados aumentó de 6 en el período 1992 - 2001 a 48 en el período 2002 - 2012. Por otra parte, el 76 % de los artículos analizados llega a la conclusión de que existe una estrecha relación entre las condiciones de trabajo analizadas y el impacto en la salud física y mental de los trabajadores. No obstante, con un porcentaje del 9 % diferentes investigaciones exponen la relación entre las condiciones favorables de trabajo y el incremento en la productividad. Conclusiones: Los avances realizados en el campo han dado frutos y actualmente se están estimando nuevas metodologías y/o herramientas que permitan evaluar las condiciones a las que están expuestos los trabajadores, y de esta manera involucrarlos a conseguir no solo los objetivos financieros y de operaciones de la empresa, sino también los beneficios en pro de su desarrollo personal y profesional.

  3. Nutrient Status of Adults with Cystic Fibrosis

    Science.gov (United States)

    GORDON, CATHERINE M.; ANDERSON, ELLEN J.; HERLYN, KAREN; HUBBARD, JANE L.; PIZZO, ANGELA; GELBARD, RONDI; LAPEY, ALLEN; MERKEL, PETER A.

    2011-01-01

    Nutrition is thought to influence disease status in patients with cystic fibrosis (CF). This cross-sectional study sought to evaluate nutrient intake and anthropometric data from 64 adult outpatients with cystic fibrosis. Nutrient intake from food and supplements was compared with the Dietary Reference Intakes for 16 nutrients and outcomes influenced by nutritional status. Attention was given to vitamin D and calcium given potential skeletal implications due to cystic fibrosis. Measurements included weight, height, body composition, pulmonary function, and serum metabolic parameters. Participants were interviewed about dietary intake, supplement use, pulmonary function, sunlight exposure, and pain. The participants’ mean body mass index (±standard deviation) was 21.8±4.9 and pulmonary function tests were normal. Seventy-eight percent used pancreatic enzyme replacement for malabsorption. Vitamin D deficiency [25-hydroxyvitamin D (25OHD)<37.5 nmol/L] was common: 25 (39%) were deficient despite adequate vitamin D intake. Lipid profiles were normal in the majority, even though total and saturated fat consumption represented 33.0% and 16.8% of energy intake, respectively. Reported protein intake represented 16.9% of total energy intake (range 10%–25%). For several nutrients, including vitamin D and calcium, intake from food and supplements in many participants exceeded recommended Tolerable Upper Intake Levels. Among adults with cystic fibrosis, vitamin D deficiency was common despite reported adequate intake, and lipid profiles were normal despite a relatively high fat intake. Mean protein consumption was adequate, but the range of intake was concerning, as both inadequate or excessive intake may have deleterious skeletal effects. These findings call into question the applicability of established nutrient thresholds for patients with cystic fibrosis. PMID:18060897

  4. Los gestionadores del recurso humano en el mercado de trabajo

    Directory of Open Access Journals (Sweden)

    Jesús Castañeda Palacios

    1991-05-01

    Full Text Available RESUMEN El artículo presenta las diferentes alternativas cuando se consulta a los gestionadores, que participan en  el Mercado de Trabajo, para la consecución del recurso humano, con la finalidad de llenar las vacancias existentes en las empresas. Una segunda óptica apunta a visualizar la intervención del Estado, en el campo de la intermediación Laboral y la relación con los particulares que ejercen esta actividad. Finalmente, se plantean algunas tendencias sobre la manera como se desenvolverán esta clase de organizaciones a la Luz de la ley 50 de 1990 (Reforma laboral.

  5. La gerencia aclarada en el trabajo del enfermero

    Directory of Open Access Journals (Sweden)

    Mendes Isabel Amélia Costa

    2002-01-01

    Full Text Available La gerencia aclarada presupone que todo individuo de prioridad a una conducta fuerte y determinada, en detrimento de una conducta pasiva. Presupone también una profunda preocupación con las cuestiones de la especie humana, los problemas éticos, la relación con la naturaleza, en fin, con el futuro del hombre. De esta forma, las autoras, basadas en los presupuestos subyacentes a la política de gerencia aclarada de Maslow(1, tienen el objetivo de centralizar este tipo de gerencia en el trabajo del enfermero. Creen que, a través de ésta reflexión los enfermeros podrán incorporar en su práctica nuevos valores, más sintonizados con la naturaleza humana.

  6. La gerencia aclarada en el trabajo del enfermero

    Directory of Open Access Journals (Sweden)

    Isabel Amélia Costa Mendes

    Full Text Available La gerencia aclarada presupone que todo individuo de prioridad a una conducta fuerte y determinada, en detrimento de una conducta pasiva. Presupone también una profunda preocupación con las cuestiones de la especie humana, los problemas éticos, la relación con la naturaleza, en fin, con el futuro del hombre. De esta forma, las autoras, basadas en los presupuestos subyacentes a la política de gerencia aclarada de Maslow(1, tienen el objetivo de centralizar este tipo de gerencia en el trabajo del enfermero. Creen que, a través de ésta reflexión los enfermeros podrán incorporar en su práctica nuevos valores, más sintonizados con la naturaleza humana.

  7. MUJER, TRABAJO Y FAMILIA EN ESPAÑA

    Directory of Open Access Journals (Sweden)

    Nuria Legazpe

    2015-01-01

    Full Text Available El objetivo de este artículo es analizar los determinantes de las decisiones de parti - cipación laboral, convivencia en pareja y no maternidad de las mujeres en España. Para alcanzar este objetivo se ha explotado la Encuesta de Condiciones de Vida ( EU - SILC , por sus siglas en inglés (2005-2011 de la Oficina Europea de Estadís - tica (Eurostat, por sus siglas en inglés. La estrategia empírica ha consistido en un modelo probit trivariante, lo que permite estimar las tres variables dependientes de manera simultánea. Los resultados muestran, entre otros datos, que las mujeres con mayor nivel educativo tienen mayor probabilidad de participar en el merca - do de trabajo y no tener hijos, así como una menor probabilidad de cohabitar en pareja.

  8. Trabajo y postemancipación en Haití

    Directory of Open Access Journals (Sweden)

    Javier Laviña

    2015-02-01

    Full Text Available Este artículo analiza las estructuras sociales subyacentes a la Revolución haitiana, y cómo las aspiraciones diferentes de negros y mulatos durante la Revolución de independencia (1791-1804 se trasladaron al período postabolición. Pese a los cambios en la legislación agraria después de la independencia, el fracaso a la hora de proporcionar unas condiciones de trabajo adaptadas a las demandas de los trabajadores rurales haitianos se añadió a las dificultades y los obstáculos enfrentados por Haití en su intento por construir una nación próspera y en libertad.

  9. Delimitación del Constructo Voluntad de Trabajo

    Directory of Open Access Journals (Sweden)

    Gabriela Lozzia

    2014-12-01

    Full Text Available Ante la queja habitual de los docentes universitarios acerca de la poca perseverancia y disposición al esfuerzo de sus alumnos, se buscó definir conceptualmente el rasgo Voluntad de Trabajo (VT para la construcción de una escala. Se vinculó con el Modelo de Control de la Acción de Kuhl. Se estudiaron los Modelos de Personalidad (Guilford, Cattell, Eysenck, Cinco Grandes y Zuckerman para identificar las dimensiones relacionadas y sus indicadores. La VT se caracterizó como la actitud por la cual un individuo se aboca a sus obligaciones con responsabilidad, eficiencia, automotivación y sin dilaciones. Se relacionó con la capacidad para generar procesos volitivos que lo comprometan en el inicio, continuación y concreción de una tarea sin que tendencias contrarias logren desviarlo.

  10. DOCUMENTO: LA PRACTICA PROFESIONAL EN EL PROGRAMA DE TRABAJO SOCIAL

    Directory of Open Access Journals (Sweden)

    Liliana Pérez Mendoza

    2001-08-01

    Full Text Available La Facultad de Ciencias Sociales y Educación a través del Departamento de Practicas y el programa de Trabajo Social de la misma proyectan la acción de los Trabajadores Sociales en formación en diferentes áreas temáticas a fin de propiciar en los diferentes contextos donde tiene lugar, un desarrollo social, humano y sostenible con la participación en diferentes comunidades de la ciudad y la región, de docentes y estudiantes, a través de’ estrategias de acción profesional como: diagnósticos participativos, programas / proyectos de integración comunitaria, de generación de ingresos, de Desarrollo a Organizacional, de fortalecimiento de vínculos familiares, de convivencia ciudadana y de Desarrollo Municipal.

  11. El trabajo colaborativo y la inclusión social

    Directory of Open Access Journals (Sweden)

    Amelia Berenice Barragán de Anda

    2010-04-01

    Full Text Available En este artículo se incluyen algunas reflexiones sobre el trabajo colaborativo y el impacto que éste tiene en el proceso de aprendizaje, no sólo en cuanto a la aprehensión de contenidos teórico-académicos, sino también a la adquisición de habilidades digitales, reconocimiento de actitudes, desarrollo de destrezas y aptitudes útiles para ser buen estudiante y para mejorar la práctica profesional a través de la convivencia generada por el trabajo colaborativo. El aprendizaje colaborativo posibilita el desarrollo de saberes teóricos, prácticos y formativos. Estos últimos permiten enfrentar un mundo cambiante con pensamiento crítico, así como habilidades de relación y comunicación, tolerancia, respeto y disposición a escuchar. Estas competencias tienen su base en las interactividad intencionada con un propósito definido de colaboración. La educación a distancia, a través de las estrategias utilizadas en los ambientes virtuales, funciona para "acercar" a los usuarios, ya que facilitan las interacciones sociales, la creación de redes sin importar las barreras físicas, de horario y heterogeneidad cultural. El egresado de esta modalidad educativa se beneficia por desarrollar dominio disciplinar y competencias transversales, como seguridad profesional, autoconfianza, lucha contra las resistencias tecnológicas, imposición de retos y logro de objetivos.

  12. A CD36 synthetic peptide inhibits silica-induced lung fibrosis in the mice.

    Science.gov (United States)

    Wang, Xin; Lv, Lina; Chen, Ying; Chen, Jie

    2010-02-01

    Silicosis is a kind of pneumoconiosis caused by inhalation of silica dust, which is characterized by lung fibrosis. The biologically active form of transforming growth factor-beta1 (TGF-beta1) plays a key role in the development of lung fibrosis. CD36 is involved in the transformation of latent TGF-beta1 (L-TGF-beta1) to active TGF-beta1. The antagonistic effect of the synthetic peptide was analyzed by the administration of CD36 (93-110) synthetic peptide to the silicosis model of mice. The hydroxyproline content of the silica + CD36 (93-110) synthetic peptide group was significantly lower than that of the other experimental groups [silica and silica + CD36 (208-225) synthetic peptide groups] (p synthetic peptide group were less than those of the other experimental groups. The expressions of collagen I and III of the silica + CD36 (93-110) synthetic peptide group were significantly lower than those of the other experimental groups (p synthetic peptide reduced the tissue fibrotic pathologies and collagen accumulation in the silicosis model of mice, resulting in the decreased severity of silica-induced lung fibrosis.

  13. Nuestro Trabajo: Primaria para Adultos. Segunda Parte. Edicion Experimental (Our Work: Primer for Adults. Part Two. Experimental Edition).

    Science.gov (United States)

    Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

    This workbook is part of a Mexican series of instructional materials designed for Spanish speaking adults who are in the process of becoming literate or have recently become literate in their native language. This workbook is designed to orient people who are only recently literate to the world of work and business. Topics covered include worker…

  14. Physical exercise training for cystic fibrosis.

    Science.gov (United States)

    Radtke, Thomas; Nevitt, Sarah J; Hebestreit, Helge; Kriemler, Susi

    2017-11-01

    Physical exercise training may form an important part of regular care for people with cystic fibrosis. This is an update of a previously published review. To assess the effects of physical exercise training on exercise capacity by peak oxygen consumption, pulmonary function by forced expiratory volume in one second, health-related quality of life and further important patient-relevant outcomes in people with cystic fibrosis. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Date of the most recent search: 04 May 2017.We searched ongoing trials registers (clinicaltrials.gov and the WHO ICTRP). Date of most recent search: 10 August 2017. All randomised and quasi-randomised controlled clinical trials comparing exercise training of any type and a minimum duration of two weeks with conventional care (no training) in people with cystic fibrosis. Two authors independently selected studies for inclusion, assessed methodological quality and extracted data. The quality of the evidence was assessed using the GRADE system. Of the 83 studies identified, 15 studies which included 487 participants, met the inclusion criteria. The numbers in each study ranged from nine up to 72 participants; two studies were in adults, seven were in children and adolescents and six studies included all age ranges. Four studies of hospitalised participants lasted less than one month and 11 studies were outpatient-based, lasting between two months and three years. The studies included participants with a wide range of disease severity and employed differing levels of supervision with a mixture of types of training. There was also wide variation in the quality of the included studies.This systematic review shows very low- to low-quality evidence from both short- and long-term studies that in people

  15. Inhibition of PTEN Activity Aggravates Post Renal Fibrosis in Mice with Ischemia Reperfusion-Induced Acute Kidney Injury

    Directory of Open Access Journals (Sweden)

    Jun Zhou

    2017-10-01

    Full Text Available Background: Renal fibrosis is a common pathophysiological feature of chronic kidney disease. Acute kidney injury (AKI is defined as an independent causal factor of chronic kidney disease, with a pathological representation of post renal fibrosis. However, the etiopathogenesis underlying post renal fibrosis induced by AKI is not completely understood. Methods: BALB/c mice were treated with bpv or vehicle controls and were, respectively, the ischemia reperfusion (IR model group and control group. All of the animals had blood taken from the orbital venous plexus at 24 hours after IR. Six mice in each group were randomly chosen and euthanized 7 days after IR treatment, and the remaining six mice in each group were euthanized 14 days after IR treatment. We examined the effect on post kidney fibrosis of inhibiting PTEN activity in mice in an IR induced AKI experimental model. Results: Compared with vehicle mice, bpv-(PTEN specific inhibitor treated mice accumulated more bone marrow-derived fibroblasts and myofibroblasts in the kidneys. Inhibition of PTEN activity increased the expression of α-smooth muscle actin and extracellular matrix proteins and post kidney fibrosis. Furthermore, inhibition of PTEN activity resulted in more inflammatory cytokines in the kidneys of mice subjected to IR-induced renal fibrosis. Moreover, inhibition of PTEN activity up-regulated PI3K protein expression and Akt phosphorylation. Conclusions: Our study demonstrated that PTEN played an important role in post renal fibrosis in mice with ischemia reperfusion-induced AKI. These results indicated that the PTEN/PI3K/Akt signaling pathway may serve as a novel therapeutic target for AKI-induced chronic kidney disease.

  16. Factors Promoting Development of Fibrosis in Crohn’s Disease

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    Gerhard Rogler

    2017-07-01

    Full Text Available The concepts on the pathophysiology of intestinal fibrosis in Crohn’s disease (CD have changed in recent years. Some years ago fibrosis was regarded to be a consequence of long-standing inflammation with subsequent destruction of the gut wall matrix followed by scar formation and collagen deposition. Fibrosis in CD patients appeared to be an irreversible process that could hardly be influenced. Therefore, the main target in CD therapy was to control inflammation to avoid fibrosis development. Many of these assumptions seem to be only partially true. Inflammation may be a necessary prerequisite for the initiation of fibrosis. However, when the pathophysiologic processes that lead to fibrosis in CD patients have been initiated fibrosis development may be independent of inflammation and may continue even when inflammation is under good medical control. Fibrosis in CD also may be reversible. After strictureplasty local collagen deposits decrease or even disappear. With new animal models for intestinal fibrosis on the horizon, we need to spend more efforts on understanding the factors influencing fibrosis in CD patients to finally find specific therapies. In this context, it will be as important to find markers and quantitative imaging tools to have reliable endpoints for clinical trials in fibrosing CD.

  17. Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition.

    Science.gov (United States)

    Pauta, Montse; Ribera, Jordi; Melgar-Lesmes, Pedro; Casals, Gregori; Rodríguez-Vita, Juan; Reichenbach, Vedrana; Fernandez-Varo, Guillermo; Morales-Romero, Blai; Bataller, Ramon; Michelena, Javier; Altamirano, Jose; Jiménez, Wladimiro; Morales-Ruiz, Manuel

    2015-04-01

    Studies in experimental models of cirrhosis showed that anti-angiogenic treatments may be effective for the treatment of liver fibrosis. In this context, angiopoietins are potential therapeutic targets as they are involved in the maintenance and stabilization of newly formed blood vessels. In addition, angiopoietin-2 is expressed in fibrotic livers and its inhibition in tumours results in vessel stability. Therefore, our study was aimed to assess the therapeutic utility of inhibiting angiopoietin-2. Circulating levels of angiopoietin-1 and angiopoietin-2 were quantified by ELISA in CCl4 -treated rats and in patients with cirrhosis. In vivo blockade of angiopoietin-2 in rats with liver fibrosis was performed with a chemically programmed antibody, CVX-060. High levels of angiopoietin-2 were found in the systemic and suprahepatic circulation of cirrhotic patients and the ratio angiopoietin-1/angiopoietin-2 inversely correlated with prognostic models for alcoholic liver disease. Chronic treatment of CCl4 -treated rats with CVX-060 was associated with a significant decrease in inflammatory infiltrate, normalization of the hepatic microvasculature and reduction in VCAM-1 vascular expression. The anti-angiopoietin-2 treatment was also associated with less liver fibrosis and with lower levels of circulating transaminases. CVX-060 treatment was not associated with either vascular pruning in healthy tissue or compensatory overexpression of VEGF. Inhibition of angiopoietin-2 is an effective and safe treatment for liver fibrosis in CCl4 -treated rats, acting mainly through the induction of vessel normalization and the attenuation of hepatic inflammatory infiltrate. Therefore, inhibition of angiopoietin-2 offers a therapeutic alternative for liver fibrosis. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. A novel collaborative representation and SCAD based classification method for fibrosis and inflammatory activity analysis of chronic hepatitis C

    Science.gov (United States)

    Cai, Jiaxin; Chen, Tingting; Li, Yan; Zhu, Nenghui; Qiu, Xuan

    2018-03-01

    In order to analysis the fibrosis stage and inflammatory activity grade of chronic hepatitis C, a novel classification method based on collaborative representation (CR) with smoothly clipped absolute deviation penalty (SCAD) penalty term, called CR-SCAD classifier, is proposed for pattern recognition. After that, an auto-grading system based on CR-SCAD classifier is introduced for the prediction of fibrosis stage and inflammatory activity grade of chronic hepatitis C. The proposed method has been tested on 123 clinical cases of chronic hepatitis C based on serological indexes. Experimental results show that the performance of the proposed method outperforms the state-of-the-art baselines for the classification of fibrosis stage and inflammatory activity grade of chronic hepatitis C.

  19. Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling

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    Jiang Liu

    2012-01-01

    Full Text Available The Na/K-ATPase is the primary force regulating renal sodium handling and plays a key role in both ion homeostasis and blood pressure regulation. Recently, cardiotonic steroids (CTS-mediated Na/K-ATPase signaling has been shown to regulate fibrosis, renal proximal tubule (RPT sodium reabsorption, and experimental Dahl salt-sensitive hypertension in response to a high-salt diet. Reactive oxygen species (ROS are an important modulator of nephron ion transport. As there is limited knowledge regarding the role of ROS-mediated fibrosis and RPT sodium reabsorption through the Na/K-ATPase, the focus of this review is to examine the possible role of ROS in the regulation of Na/K-ATPase activity, its signaling, fibrosis, and RPT sodium reabsorption.

  20. The Human Amnion Epithelial Cell Secretome Decreases Hepatic Fibrosis in Mice with Chronic Liver Fibrosis

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    Majid Alhomrani

    2017-10-01

    Full Text Available Background: Hepatic stellate cells (HSCs are the primary collagen-secreting cells in the liver. While HSCs are the major cell type involved in the pathogenesis of liver fibrosis, hepatic macrophages also play an important role in mediating fibrogenesis and fibrosis resolution. Previously, we observed a reduction in HSC activation, proliferation, and collagen synthesis following exposure to human amnion epithelial cells (hAEC and hAEC-conditioned media (hAEC-CM. This suggested that specific factors secreted by hAEC might be effective in ameliorating liver fibrosis. hAEC-derived extracellular vesicles (hAEC-EVs, which are nanosized (40–100 nm membrane bound vesicles, may act as novel cell–cell communicators. Accordingly, we evaluated the efficacy of hAEC-EV in modulating liver fibrosis in a mouse model of chronic liver fibrosis and in human HSC.Methods: The hAEC-EVs were isolated and characterized. C57BL/6 mice with CCl4-induced liver fibrosis were administered hAEC-EV, hAEC-CM, or hAEC-EV depleted medium (hAEC-EVDM. LX2 cells, a human HSC line, and bone marrow-derived mouse macrophages were exposed to hAEC-EV, hAEC-CM, and hAEC-EVDM. Mass spectrometry was used to examine the proteome profile of each preparation.Results: The extent of liver fibrosis and number of activated HSCs were reduced significantly in CCl4-treated mice given hAEC-EVs, hAEC-CM, and hAEC EVDM compared to untreated controls. Hepatic macrophages were significantly decreased in all treatment groups, where a predominant M2 phenotype was observed. Human HSCs cultured with hAEC-EV and hAEC-CM displayed a significant reduction in collagen synthesis and hAEC-EV, hAEC-CM, and hAEC-EVDM altered macrophage polarization in bone marrow-derived mouse macrophages. Proteome analysis showed that 164 proteins were unique to hAEC-EV in comparison to hAEC-CM and hAEC-EVDM, and 51 proteins were co-identified components with the hAEC-EV fraction.Conclusion: This study provides novel data

  1. Systems genetics of liver fibrosis: identification of fibrogenic and expression quantitative trait loci in the BXD murine reference population.

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    Rabea A Hall

    Full Text Available The progression of liver fibrosis in response to chronic injury varies considerably among individual patients. The underlying genetics is highly complex due to large numbers of potential genes, environmental factors and cell types involved. Here, we provide the first toxicogenomic analysis of liver fibrosis induced by carbon tetrachloride in the murine 'genetic reference panel' of recombinant inbred BXD lines. Our aim was to define the core of risk genes and gene interaction networks that control fibrosis progression. Liver fibrosis phenotypes and gene expression profiles were determined in 35 BXD lines. Quantitative trait locus (QTL analysis identified seven genomic loci influencing fibrosis phenotypes (pQTLs with genome-wide significance on chromosomes 4, 5, 7, 12, and 17. Stepwise refinement was based on expression QTL mapping with stringent selection criteria, reducing the number of 1,351 candidate genes located in the pQTLs to a final list of 11 cis-regulated genes. Our findings demonstrate that the BXD reference population represents a powerful experimental resource for shortlisting the genes within a regulatory network that determine the liver's vulnerability to chronic injury.

  2. Congenital Fibrosis of the Extraocular Muscles

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    Leyla Niyaz

    2014-08-01

    Full Text Available Congenital fibrosis of the extraocular muscles (CFEOM is a rare disorder characterized by hereditary non-progressive restrictive strabismus and blepharoptosis. Although most of the cases are bilateral and isolated, some patients may have systemic findings. CFEOM is divided into three groups as CFEOM 1, 2, and 3 according to the phenotype. Primary responsible genes are KIF21A for CFEOM type 1 and 3 and PHOX2A/ARIX gene for CFEOM type 2. Studies suggest that abnormal innervation of the extraocular muscles is the cause of muscle fibrosis. Early treatment is important because of the risk of amblyopia. Surgery is the primary treatment option for strabismus and blepharoptosis. (Turk J Ophthalmol 2014; 44: 312-5

  3. Painful connections: densification versus fibrosis of fascia.

    Science.gov (United States)

    Pavan, Piero G; Stecco, Antonio; Stern, Robert; Stecco, Carla

    2014-01-01

    Deep fascia has long been considered a source of pain, secondary to nerve pain receptors becoming enmeshed within the pathological changes to which fascia are subject. Densification and fibrosis are among such changes. They can modify the mechanical properties of deep fasciae and damage the function of underlying muscles or organs. Distinguishing between these two different changes in fascia, and understanding the connective tissue matrix within fascia, together with the mechanical forces involved, will make it possible to assign more specific treatment modalities to relieve chronic pain syndromes. This review provides an overall description of deep fasciae and the mechanical properties in order to identify the various alterations that can lead to pain. Diet, exercise, and overuse syndromes are able to modify the viscosity of loose connective tissue within fascia, causing densification, an alteration that is easily reversible. Trauma, surgery, diabetes, and aging alter the fibrous layers of fasciae, leading to fascial fibrosis.

  4. Lymphoplasmacytic Sclerosing Pancreatitis and Retroperitoneal Fibrosis

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    Nigel K. F. Koo Ng

    2008-01-01

    Full Text Available Although cases of lymphoplasmacytic sclerosing pancreatitis (LSP associated with idiopathic retroperitoneal fibrosis have been reported, the association is rare. We describe a 74-year-old man who presented with obstructive jaundice and weight loss. Nineteen months earlier, he had been diagnosed with idiopathic retroperitoneal fibrosis and treated with bilateral ureteric stents. Initial investigations were suggestive of a diagnosis of LSP, however, a malignant cause could not be ruled out. He underwent an exploratory laparotomy and frozen sections confirmed the diagnosis of LSP. An internal biliary bypass was performed using a Roux loop of jejunum, and the patient made an uneventful recovery. This case illustrates the difficulty in distinguishing LSP from pancreatic carcinoma preoperatively.

  5. Resiliencia: Contexto no clínico para trabajo social

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    Ángela María Quintero Velásquez

    2005-05-01

    Full Text Available Resiliencia es un término nuevo, mas no el fenómeno que representa. El concepto que surge a mediados del siglo pasado, se adopta de las ciencias naturales (física y osteología, y ya está incluido en el campo social.La Resiliencia ofrece alternativas a todos los profesionales, pero todavía no es un concepto homogéneo. La Resiliencia es un cambio de paradigma: privilegia el enfoque en las fortalezas, no en el déficit o problema. Involucra a los individuos, familias, grupos, comunidades e instituciones a que sean parte de la solución con el conjunto de recursos internos y externos que permitan enfrentar situaciones críticas de todo tipo. Se supera la noción de Resiliencia individual y se conceptualiza en América latina sobre la resiliencia familiar o relacional, comunitaria, andina y empresarial.La Resiliencia familiar implica: vínculo emocional significativo, conductas éticas, soporte espiritual y contexto ecológico. Los factores resilientes de la familia son la cohesión, la comunicación, la adaptación, la afectividad.Para el Trabajo Social contemporáneo y otras profesiones del desarrollo humano, el construccionismo sustenta el principio de fortalecer la habilidad de las personas para sobrellevar las tareas y los problemas que enfrentan en la vida. Los profesionales de estas áreas, están preparados para actuar en Contextos no Clínicos de atención sociofamiliar: recepción-orientación, evaluación, prevención, promoción, educación. Asumen la resiliencia como enfoque y estrategia metodológica.La producción teórica sobresaliente de Resiliencia en Trabajo Social está en Colombia (Universidad de Antioquia, Costa Rica y España, pero es utilizada en gran variedad de proyectos de desarrollo humano.

  6. Resiliencia: Contexto no clínico para trabajo social

    Directory of Open Access Journals (Sweden)

    Ángela María Quintero Velásquez

    2005-01-01

    Full Text Available Resiliencia es un término nuevo, mas no el fenómeno que representa. El concepto que surge a mediados del siglo pasado, se adopta de las ciencias naturales (física y osteología, y ya está incluido en el campo social. La Resiliencia ofrece alternativas a todos los profesionales, pero todavía no es un concepto homogéneo. La Resiliencia es un cambio de paradigma: privilegia el enfoque en las fortalezas, no en el déficit o problema. Involucra a los individuos, familias, grupos, comunidades e instituciones a que sean parte de la solución con el conjunto de recursos internos y externos que permitan enfrentar situaciones críticas de todo tipo. Se supera la noción de Resiliencia individual y se conceptualiza en América latina sobre la resiliencia familiar o relacional, comunitaria, andina y empresarial. La Resiliencia familiar implica: vínculo emocional significativo, conductas éticas, soporte espiritual y contexto ecológico. Los factores resilientes de la familia son la cohesión, la comunicación, la adaptación, la afectividad. Para el Trabajo Social contemporáneo y otras profesiones del desarrollo humano, el construccionismo sustenta el principio de fortalecer la habilidad de las personas para sobrellevar las tareas y los problemas que enfrentan en la vida. Los profesionales de estas áreas, están preparados para actuar en Contextos no Clínicos de atención sociofamiliar: recepción-orientación, evaluación, prevención, promoción, educación. Asumen la resiliencia como enfoque y estrategia metodológica. La producción teórica sobresaliente de Resiliencia en Trabajo Social está en Colombia (Universidad de Antioquia, Costa Rica y España, pero es utilizada en gran variedad de proyectos de desarrollo humano

  7. Inspiratory muscle training for cystic fibrosis.

    Science.gov (United States)

    Houston, Brian W; Mills, Nicola; Solis-Moya, Arturo

    2013-11-21

    Cystic fibrosis is the most common life-limiting genetic condition in Caucasians and the life-expectancy of those newly diagnosed is increasing. Inspiratory muscle training may be a way of improving the lung function and quality of life of people with cystic fibrosis. Hence there is a need to establish whether this intervention is beneficial. To determine the effect of inspiratory muscle training on health-related quality of life, pulmonary function and exercise tolerance. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials register comprising of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Date of most recent search: 08 July 2013. Randomised or quasi-randomised clinical controlled trials comparing different inspiratory muscle training regimens with each other or a control in people with cystic fibrosis. Three review authors independently applied the inclusion and exclusion criteria to publications and assessed the quality of the included studies. Fourteen studies were identified. Of these eight studies with 180 participants met the review inclusion criteria. There was wide variation in the quality of the included studies. Data were not published in sufficient detail or with sufficiently similar outcome measures in these studies to perform meta-analyses. We have not found any evidence to suggest that this treatment is either beneficial or not. We would advise that practitioners evaluate on a case-by-case basis whether or not to employ this therapy. We recommend that future studies make more use of health-related quality of life and exercise tolerance measures; and that there is an agreement upon a single standard measure of classifying the clinical status of the participants.

  8. The JNK Signaling Pathway in Renal Fibrosis

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    Keren Grynberg

    2017-10-01

    Full Text Available Fibrosis of the glomerular and tubulointerstitial compartments is a common feature of chronic kidney disease leading to end-stage renal failure. This fibrotic process involves a number of pathologic mechanisms, including cell death and inflammation. This review focuses on the role of the c-Jun amino terminal kinase (JNK signaling pathway in the development of renal fibrosis. The JNK pathway is activated in response to various cellular stresses and plays an important role in cell death and inflammation. Activation of JNK signaling is a common feature in most forms of human kidney injury, evident in both intrinsic glomerular and tubular cells as well as in infiltrating leukocytes. Similar patterns of JNK activation are evident in animal models of acute and chronic renal injury. Administration of JNK inhibitors can protect against acute kidney injury and suppress the development of glomerulosclerosis and tubulointerstitial fibrosis. In particular, JNK activation in tubular epithelial cells may be a pivotal mechanism in determining the outcome of both acute kidney injury and progression of chronic kidney disease. JNK signaling promotes tubular epithelial cell production of pro-inflammatory and pro-fibrotic molecules as well as tubular cell de-differentiation toward a mesenchymal phenotype. However, the role of JNK within renal fibroblasts is less well-characterized. The JNK pathway interacts with other pro-fibrotic pathways, most notable with the TGF-β/SMAD pathway. JNK activation can augment TGF-β gene transcription, induce expression of enzymes that activate the latent form of TGF-β, and JNK directly phosphorylates SMAD3 to enhance transcription of pro-fibrotic molecules. In conclusion, JNK signaling plays an integral role in several key mechanisms operating in renal fibrosis. Targeting of JNK enzymes has therapeutic potential for the treatment of fibrotic kidney diseases.

  9. MR imaging of pancreas in cystic fibrosis

    International Nuclear Information System (INIS)

    Murayama, S.; Robinson, A.E.; Mulvihill, D.M.; Stallworth, J.M.; Goyco, P.G.; Beckerman, R.C.; Hines, M.R.

    1990-01-01

    The pancreatic regions of 18 patients with cystic fibrosis were analyzed with a 1.5 Tesla MR unit. Signal intensity of the pancreas was correlated with clinical data and ultrasound. A hyperintense pancreas on T1-weighted image was consistent with fatty replacement of pancreatic insufficiency. A pancreas of normal soft tissue intensity was found in two asymptomatic and one symptomatic patient. A very hypointense pancreas on any pulse sequence was considered to be an intermediate stage of pancreatic degeneration. (orig.)

  10. Nephrogenic systemic fibrosis: clinical picture and treatment

    DEFF Research Database (Denmark)

    Marckmann, Peter; Skov, Lone

    2009-01-01

    The classic hallmark symptoms of advanced nephrogenic systemic fibrosis (NSF) (skin thickening, hardening and hyperpigmentation, and disabling contractures in renal failure patients) in temporal association with Gd-based contrast agent (GBCA) exposure are almost pathognomonic of NSF. Less obvious...... cases may be diagnosed on the basis of history of early GBCA-related NSF symptoms (warm swellings, pain, discoloration, itching of lower legs), signs of multiorgan involvement (lungs, nervous system), the exclusion of differential diagnoses, including scleromyxedema and systemic sclerosis...

  11. Subcutaneous fibrosis after whole neck irradiation

    International Nuclear Information System (INIS)

    Hirota, Saeko; Tsujino, Kayoko; Oshitani, Takashi; Hishikawa, Yoshio; Takada, Yoshiki; Kono, Michio; Abe, Mitsuyuki

    2002-01-01

    Purpose: To identify the risk factors for moderate to severe subcutaneous fibrosis after whole neck irradiation. Methods and Materials: We analyzed 233 cases of patients who had undergone whole neck irradiation with 4-MV X-ray or 8-10-MeV electrons, or both, and had been followed with regard to their skin condition for at least 1 year. The prescribed dose to the whole neck ranged from 19.2 to 72.4 Gy (median 50). The skin-absorbed dose was specified as that at a depth of 4.1 mm (d4.1-mm depth ), and a biologically equivalent dose (BED) of d4.1-mm depth was also estimated (BED 1.8 4.1-mm depth ). Results: Univariate analysis revealed that previous neck dissection, concurrent chemotherapy, corticosteroid administration as a part of chemotherapy, fractionation, and BED 1.8 4.1-mm depth were significant prognostic variables. Multivariate analysis showed that BED 1.8 4.1-mm depth and previous neck dissection were the only prognostic variables for moderate to severe subcutaneous fibrosis. Conclusion: A high dose to a 4.1-mm depth of the skin and a history of neck dissection were identified as the predominant risk factors for moderate to severe subcutaneous fibrosis after whole neck irradiation. A subcutaneous dose should be considered in radiotherapy treatment planning involving the whole neck, especially in cases in which patients have undergone previous neck dissection

  12. Cystic fibrosis: a mucosal immunodeficiency syndrome

    Science.gov (United States)

    Cohen, Taylor Sitarik; Prince, Alice

    2013-01-01

    Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that regulates the transport of ions and the movement of water across the epithelial barrier. Mutations in CFTR, which form the basis for the clinical manifestations of cystic fibrosis, affect the epithelial innate immune function in the lung, resulting in exaggerated and ineffective airway inflammation that fails to eradicate pulmonary pathogens. Compounding the effects of excessive neutrophil recruitment, the mutant CFTR channel does not transport antioxidants to counteract neutrophil-associated oxidative stress. Whereas mutant CFTR expression in leukocytes outside of the lung does not markedly impair their function, the expected regulation of inflammation in the airways is clearly deficient in cystic fibrosis. The resulting bacterial infections, which are caused by organisms that have substantial genetic and metabolic flexibility, can resist multiple classes of antibiotics and evade phagocytic clearance. The development of animal models that approximate the human pulmonary phenotypes—airway inflammation and spontaneous infection—may provide the much-needed tools to establish how CFTR regulates mucosal immunity and to test directly the effect of pharmacologic potentiation and correction of mutant CFTR function on bacterial clearance. PMID:22481418

  13. Neuroendocrine tumors and fibrosis: An unsolved mystery?

    Science.gov (United States)

    Laskaratos, Faidon-Marios; Rombouts, Krista; Caplin, Martyn; Toumpanakis, Christos; Thirlwell, Christina; Mandair, Dalvinder

    2017-12-15

    Neuroendocrine tumors are a heterogeneous group of slow-growing neoplasms arising mainly from the enterochromaffin cells of the digestive and respiratory tract. Although they are relatively rare, their incidence is rising. It has long been observed that they often are associated with the development of fibrosis, both local and distant. Fibrotic complications, such as carcinoid heart disease and mesenteric desmoplasia, may lead to considerable morbidity or even affect prognosis. The elucidation of the pathophysiology of fibrosis would be of critical importance for the development of targeted therapeutic strategies. In this article, the authors review the available evidence regarding the biological basis of fibrosis in neuroendocrine tumors. They explore the role of the tumor microenvironment and the interplay between tumor cells and fibroblasts as a key factor in fibrogenesis and tumor development/progression. They also review the role of serotonin, growth factors, and other peptides in the development of carcinoid-related fibrotic reactions. Cancer 2017;123:4770-90. © 2017 American Cancer Society. © 2017 American Cancer Society.

  14. Talento humano y trabajo en equipo del personal directivo de las universidades del municipio Maracaibo

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    Maribel Medina Fuenmayor

    2010-01-01

    Full Text Available El propósito de esta investigación fue determinar la relación entre talento humano y trabajo en equipo del personal directivo de las universidades del Municipio Maracaibo, sobre la base de los enfoques teóricos de Alles (2005, Dolan et al. (2003, Gubman (2000, Hayes (2002, Jericó (2001, entre otros. La investigación se tipificó como correlacional, no experimental y transversal, utilizando una población de 31 sujetos pertenecientes a la planta directiva de administración de las referidas universidades públicas y privadas. La técnica de recolección de datos fue la observación mediante encuesta, para lo cual se diseñaron dos (2 instrumentos de recolección de datos, estructurados con cinco alternativas de respuestas bajo una escala de actitud tipo Likert, utilizando una validez de contenido por el criterio de 10 expertos, utilizando además el análisis discriminante de ítems, lo cual permitió mayor certeza en sus diseños. La confiabilidad fue calculada por el coeficiente Alfa de Cronbach, el cual arrojó un valor de 0.99 para talento humano y 0.91 para trabajo en equipo, siendo altamente consistentes. Los resultados se analizaron mediante estadística descriptiva con frecuencias absolutas y porcentuales, soportadas con medidas de tendencia central, haciendo uso además de la estadística inferencial con pruebas no paramétricas. Como conclusión, se observó una correlación con dirección positiva y magnitud fuerte entre las variables con un índice rho de Spearman de 0.88, lo que sugiere que bajo las actuales condiciones de este estudio existe una fuerte concomitancia entre las variables.

  15. Pregnancy and cystic fibrosis: Approach to contemporary management

    Science.gov (United States)

    Tay, George; Callaway, Leonie; Bell, Scott C

    2014-01-01

    Over the previous 50 years survival of patients with cystic fibrosis has progressively increased. As a result of improvements in health care, increasing numbers of patients with cystic fibrosis are now considering starting families of their own. For the health care professionals who look after these patients, the assessment of the potential risks, and the process of guiding prospective parents through pregnancy and beyond can be both challenging and rewarding. To facilitate appropriate discussions about pregnancy, health care workers must have a detailed understanding of the various important issues that will ultimately need to be considered for any patient with cystic fibrosis considering parenthood. This review will address these issues. In particular, it will outline pregnancy outcomes for mothers with cystic fibrosis, issues that need to be taken into account when planning a pregnancy and the management of pregnancy for mothers with cystic fibrosis or mothers who have undergone organ transplantation as a result of cystic fibrosis. PMID:27512443

  16. Cystic fibrosis and renal disease: a case report

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    Al-Shawwa Baha A

    2007-06-01

    Full Text Available Abstract Background Cystic fibrosis (CF is an autosomal recessive disease that is predominantly seen in the Caucasian population and involves multiple organs. Traditionally it has been thought that the kidney is the only organ which does not seem to be generally affected by the disease although the cystic fibrosis transmembrane conductance regulator (CFTR gene is expressed in the kidney. Case presentation We report the case of an 11 year old boy with cystic fibrosis and nephrotic syndrome and review the literature that describes nephrotic syndrome and renal involvement in cystic fibrosis. Conclusion With continued advances in the management of cystic fibrosis and improvement in life expectancy, several unrecognized co-morbidities are expected to emerge. It is important to screen patients for possible co-morbidities. Urine analysis may be helpful in this group of patients and any proteinuria should raise the suspicion of cystic fibrosis-related renal disease.

  17. Research advances in immune cellular pathogenesis in liver fibrosis

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    XIAO Chunyang

    2015-09-01

    Full Text Available Liver fibrosis is the common pathological consequence of all chronic liver diseases with various etiologies. The mechanism of liver fibrosis is associated with the activation and proliferation of hepatic stellate cells (HSCs. The interaction between immune cells and HSCs can regulate the production of extracellular matrix (ECM and lead to the excessive deposition of ECM and subsequent liver fibrosis and cirrhosis. This article reviews the current understanding of the effects and action mechanisms of immune cells in the development of liver fibrosis and summarizes the regulatory functions of the innate and adaptive immune systems in liver fibrosis. Further study of the interactions between immune cells, cytokines, and HSCs and the regulatory mechanisms of the immune system will provide novel opportunity for the treatment of liver fibrosis.

  18. Leukocytes: The Double-Edged Sword in Fibrosis

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    Jakub Kryczka

    2015-01-01

    Full Text Available Skin tissue scar formation and fibrosis are often characterized by the increased production and deposition of extracellular matrix components, accompanied by the accumulation of a vast number of myofibroblasts. Scaring is strongly associated with inflammation and wound healing to regain tissue integrity in response to skin tissue injury. However, increased and uncontrolled inflammation, repetitive injury, and individual predisposition might lead to fibrosis, a severe disorder resulting in the formation of dense and stiff tissue that loses the physical properties and physiological functions of normal tissue. Fibrosis is an extremely complicated and multistage process in which bone marrow-derived leukocytes act as both pro- and antifibrotic agents, and therefore, few, if any, effective therapies are available for the most severe and lethal forms of fibrosis. Herein, we discuss the current knowledge on the multidimensional impact of leukocytes on the induction of fibrosis, focusing on skin fibrosis.

  19. Arte participativo. El trabajo como (auto representación

    Directory of Open Access Journals (Sweden)

    Ana Amado

    2010-12-01

    Full Text Available El “giro social” contemporáneo del documentalismo audiovisual y de las performances teatrales, plantea una serie de cuestiones éticas y también estéticas alrededor de las formas artísticas vueltas a la representación del padecimiento de los pueblos. Con diferentes variantes, se tiende a conceder a las identidades subalternas el centro de la escena, o de un espacio de exhibición determinado, donde explican o desempeñan acciones de acuerdo a sus respectivas experiencias, sean estas de clase, de género, de edad, sexualidad, pero que en la última década están cada vez más concentradas en el mundo del trabajo o en las consecuencias de su crisis. Los apuntes que siguen abordan esta cuestión y sus paradojas a través de la revisión de algunas experiencias argentinas recientes, entre ellas la película Estrellas, de Federico León y las intervenciones teatrales “Mucamas de hotel” de Lola Arias y “Fábrica”, de Gerardo Neuman.

  20. Aníbal Ponce: el trabajo del pensamiento

    Directory of Open Access Journals (Sweden)

    Adriana Arpini

    2006-01-01

    Full Text Available Aníbal Norberto Ponce (1898-1938 vivió una época de profundas contradicciones y transformaciones, en su propio país, Argentina, y en el mundo. La mayor parte de su obra está compuesta por ensayos de interpretación histórica, social y cultural. Una problemática resulta recurrente en sus textos: se trata de la reflexión acerca de la figura del intelectual y de su función en la sociedad. En este estudio nos preguntamos: ¿cómo, a través de sus discursos, Ponce construye y reconstruye la imagen del intelectual y de su función en la sociedad? ¿En qué consiste, desde su perspectiva, el trabajo del pensamiento? ¿Cuáles son las condiciones, las relaciones de poder, las luchas dentro del campo intelectual en las que surge la reflexión ponceana acerca de la función social de la actividad teórica? Intentamos algunas respuestas a partir de las obras en las que Ponce trabaja la problemática de manera explícita o implícita

  1. Letalidad por accidentes de trabajo en Villa Clara

    Directory of Open Access Journals (Sweden)

    Miguel Gómez Vital

    1999-01-01

    Full Text Available Se valora la problemática de la letalidad por accidentes laborales en la provincia de Villa Clara, en el período comprendido entre 1987 y 1997. Se determinan las principales causas, y fue la conducta negligente del individuo la que más incidió. En los últimos años de la década del 80 se registraron más cantidad de muertes por accidentes de trabajo, los que ocurrieron fundamentalmente en el puesto laboral. Queda puntualizado el importante rol del equipo médico en instituciones laborales.The problem of letality from working accidents in the province of Villa Clara from 1987 to 1997 was evaluated. The main causes were also determined. Individual negligent behaviour proved to be the first cause. More deaths from working accidents were registered late in the 1980s. Most of these accidents occurred at the working place. It was stressed the important role played by the medical team at the working institutions

  2. La medicina del trabajo en el gobierno nacional y popular

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    Mario Testa

    2014-01-01

    Full Text Available Este artículo reproduce un documento del Instituto de Medicina del Trabajo, creado el 16 de julio de 1973 en la Facultad de Medicina de la Universidad de Buenos Aires (UBA, en el que se transcriben las intervenciones de Mario Testa, Alberto Ozores Soler y Ricardo Saiegh en la mesa redonda “La salud en las fábricas” realizada el 1o de agosto del mismo año. Las líneas que lo anteceden, escritas por Mario Testa, contextualizan el momento histórico y destacan el sentido de aquel proyecto que replanteaba el vínculo entre las universidades y la investigación, entre la enseñanza de la medicina y el papel de los médicos en la sociedad, temas que continúan siendo vigentes. Este documento fue recuperado del fondo Mario Testa, perteneciente al Centro de Documentación e Investigación Pensar en Salud (CEDOPS del Instituto de Salud Colectiva de la Universidad Nacional de Lanús.

  3. para la investigación en trabajo social

    Directory of Open Access Journals (Sweden)

    Martín Goyette

    2005-01-01

    Full Text Available El presente artículo trata sobre cómo la integración de las personas y de los grupos sociales a la sociedad, especialmente de poblaciones vulnerables, ha sido siempre objeto central del servicio social en Quebec. Desde mediados de los años setenta, la inserción, junto a su misión de adaptación y control social, ha captado mucho más la atención del trabajo social luego de importantes cambios sociales (Goyette, 2004. Así, poblaciones que no acostumbraban a recurrir a programas de servicio social ni al Estado, –mujeres y personas en general, pero sobre todo los jóvenes- van desde entonces a ocupar el centro de interés del servicio social y de las políticas públicas. Frente a esto, el servicio social llevará su preocupación al tema de la inserción de la juventud, en la medida en que el aumento de figuras de exclusión refuerza la necesidad de favorecer los valores de solidaridad, justicia social, respeto y autonomía, bandera de esta disciplina tanto en su ética como en su práctica.

  4. Age and sex dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis

    Science.gov (United States)

    Redente, Elizabeth F.; Jacobsen, Kristen M.; Solomon, Joshua J.; Lara, Abigail R.; Faubel, Sarah; Keith, Rebecca C.; Henson, Peter M.; Downey, Gregory P.

    2011-01-01

    Fibrotic interstitial pneumonias are more prevalent in males of advancing age, although little is known about the underlying mechanisms. To evaluate the contributions of age and sex to the development of pulmonary fibrosis, we intratracheally instilled young (8–12 wk) and aged (52–54 wk) male and female mice with bleomycin and assessed the development and severity of fibrotic lung disease by measurements of lung collagen levels, static compliance, leukocyte infiltration, and stereological quantification of fibrotic areas in histological sections. We also quantified proinflammatory and profibrotic chemokine and cytokine levels in the bronchoalveolar lavage fluid. Aged male mice developed more severe lung disease, indicated by increased mortality, increased collagen deposition, and neutrophilic alveolitis compared with aged female mice or young mice of either sex. Aged male mice also exhibited increased levels of transforming growth factor-β, IL-17A, and CXCL1 in their bronchoalveolar lavage fluid. Young male mice developed a more fibrotic disease after bleomycin instillation compared with female mice, regardless of age. There was no difference in fibrosis between young and aged female mice. Taken together, these findings suggest that the variables of advanced age and male sex contribute to the severity of pulmonary fibrosis in this model. Our findings also emphasize the importance of stratifying experimental groups on the basis of age and sex in experimental and epidemiological studies of this nature. PMID:21743030

  5. Estado del arte de la seguridad y salud en el trabajo en el plan nacional de seguridad y salud en el trabajo Colombia: 2013-2017

    OpenAIRE

    Aguillón Ramírez, Mariana C.

    2014-01-01

    El presente estudio corresponde al estado del arte del Plan Nacional de Seguridad y Salud en el Trabajo Colombia 2013 – 2017 y la incorporación a este, de los principios de seguridad y salud en el trabajo promulgados por la OIT en 2008, y el marco epistémico de la seguridad y salud en el trabajo de la Universidad Nacional de Colombia. A partir de la revisión detallada de los documentos anteriormente mencionados, se prosiguió con la lectura crítica del Plan Nacional de Seguridad y Salud en el ...

  6. El videojuego League of legends y su efecto en memoria de trabajo visual y solución de problemas

    OpenAIRE

    Leyva-Rodríguez, Jesús Eduardo; Varela-García, Juan David

    2016-01-01

    El propósito de este estudio es medir los efectos que tiene el videojuego League of Legends en los procesos cognitivos de memoria de trabajo visual (MVT) y solución de problemas (SP). Para medir dichos efectos se implementó un diseño pre test-post con un grupo experimental y uno control, compuestos cada uno por siete participantes, en donde se evaluaron los procesos previamente mencionados utilizando los cubos de Corsi para MVT y las matrices del WAIS III para SP. Después de realizar los resp...

  7. Genetic modifiers of nutritional status in cystic fibrosis1234

    OpenAIRE

    Bradley, Gia M; Blackman, Scott M; Watson, Christopher P; Doshi, Vishal K; Cutting, Garry R

    2012-01-01

    Background: Improved nutrition early in life is associated with better pulmonary function for patients with cystic fibrosis (CF). However, nutritional status is poorly correlated with the CFTR genotype.

  8. Oral calorie supplements for cystic fibrosis.

    Science.gov (United States)

    Smyth, Rosalind L; Rayner, Oli

    2017-05-04

    Poor nutrition occurs frequently in people with cystic fibrosis and is associated with other adverse outcomes. Oral calorie supplements are used to increase total daily calorie intake and improve weight gain. However, they are expensive and there are concerns they may reduce the amount of food eaten and not improve overall energy intake. This is an update of a previously published review. To establish whether in people with cystic fibrosis, oral calorie supplements: increase daily calorie intake; and improve overall nutritional intake, nutritional indices, lung function, survival and quality of life. To assess adverse effects associated with using these supplements. We searched the Cochrane Cystic Fibrosis Trials Register comprising references from comprehensive electronic database searches, handsearches of relevant journals and abstract books of conference proceedings. We contacted companies marketing oral calorie supplements.Last search: 18 October 2016. Randomised or quasi-randomised controlled trials comparing use of oral calorie supplements for at least one month to increase calorie intake with no specific intervention or additional nutritional advice in people with cystic fibrosis. We independently selected the included trials, assessed risk of bias and extracted data. We contacted the authors of included trials and obtained additional information for two trials. We identified 21 trials and included three, reporting results from 131 participants lasting between three months and one year. Two trials compared supplements to additional nutritional advice and one to no intervention. Two of the included trials recruited only children. In one trial the risk of bias was low across all domains, in a second trial the risk of bias was largely unclear and in the third mainly low. Blinding of participants was unclear in two of the trials. Also, in one trial the clinical condition of groups appeared to be unevenly balanced at baseline and in another trial there were

  9. LA ESPIRITUALIDAD Y LA RELIGIÓN EN EL TRABAJO

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    Guillermo Edelberg

    2013-07-01

    Full Text Available El Dr. Robert W. Mullins, apreciado colega fallecido hace unos años, era el director del Programa Máster en Administración de Empresas del INCAE a mi llegada a esta casa de estudios. En una oportunidad, poco antes de la graduación de un nuevo grupo de estudiantes, colocó una nota de despedida en una vitrina. La leí y me pareció? y sigue pareciendo? muy acertada en su contenido y brevedad. Próximos a ingresar al frío mundo real (as you enter the cold, real world, les deseaba suerte y éxito en sus carreras profesionales. En la actualidad, cuando leo u oigo acerca de la espiritualidad en el trabajo (spirituality in the workplace, me vienen a la memoria las palabras del Dr. Mullins porque ambas expresiones aparentan contradecirse. Si se tolera la espiritualidad en el frío mundo real ¿no será que el saludo del Dr. Mullins es menos acertado de lo que pensaba? ¿Qué se entiende por “espiritualidad en el trabajo”? La pregunta no es fácil de contestar. Las res-puestas parten tanto de un punto de vista religioso como de otro que evita toda referencia a una religión. Sumado a esto están las opiniones que señalan que el lugar de la espiritualidad se halla afuera de la empresa y las que dicen que se  trata de un tema viejo con un nombre nuevo o una nueva moda que es poco más que el sensitivity training de los años 50.

  10. El trabajo público de los conceptos

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    Gómez Ramos, Antonio

    2007-12-01

    Full Text Available This paper deals with the question of how history can be learned, o some kind of hitorical wisdom can be attained, in the public realm of Modernity. Arendt’s political theory is compared with Koselleck’s history of concepts or Begriffsgeschichte. After working out, firstly, Arendt’s notion of politics as fredom of word for plural discussion and as «organized remembrance», and secondly, the definition by Koselleck of politics as a «struggle for the meaning» of socio-political concepts, I come to the «public work on the concepts», a notion which ca shed light on some present issues on histoy and memory.

    Este artículo trata de indagar en el sentido del aprendizaje de la historia, o de la elaboración del saber histórico, en la esfera política, y más precisamente, en la escena del espacio público de la modernidad. Se contrasta la noción de política en Hannah Arendt con la historia conceptual de Reinhardt Koselleck. Las definiciones arendtianas de política como libertad de palabra para la discusión plural y como recuerdo organizado se proyectan lingüísticamente en la propuesta de Koselleck de entender la política como una lucha por el significado de los conceptos sociopolíticos. El resultado es comprender la política como un «trabajo público de los conceptos», definición desde la cual se pueden aclarar algunas cuestiones sobre la historia y la memoria.

  11. Del objeto de estudio para la intervención en Trabajo Social

    OpenAIRE

    Raya Diez, Esther; Caparrós Civera, Neus

    2014-01-01

    El trabajo trata sobre el objeto de investigación en Trabajo Social. La investigación es un elemento clave del proceso de intervención. Se han analizado 106 fichas de tesis seleccionadas de la base de datos TESEO. Se han utilizado estadística descriptiva para seleccionar la muestra de tesis y las principales características analizadas. Una de las principales conclusiones de nuestro trabajo muestra que a pesar del incremento en el número de tesis vinculadas al trabajo social experi...

  12. Centralidad del trabajo y creencias asociadas en jóvenes estudiantes y adultos activos laboralmente

    OpenAIRE

    Beramendi, Maite; Ceballos, Samantha; Córdoba, Esteban; Iun Ferrero, Yamila; Sánchez, Mariana; Filippi, Graciela; Zubieta, Elena

    2007-01-01

    En el área de la psicología social del trabajo, los estudios muestran que la Competitividad y los valores asociados a la Ética Protestante del Trabajo (EPT) refieren a una orientación hacia el trabajo que enfatiza el trabajo duro, la conservación de recursos y la evitación de la haraganería. A su vez, este conjunto de valores actúa como un sistema cognitivo organizador a través del cual el mundo es percibido y explicado. Estudios previos indican que la actitud competitiva se asocia a una mayo...

  13. EVALUACION ERGONOMICA Y PSICOSOCIAL DE PUESTOS DE TRABAJO CON PANTALLA DE VISUALIZACION DE DATOS

    OpenAIRE

    Rosique-Molina, Vicente

    2012-01-01

    El presente trabajo se realiza como Trabajo Fin del Máster (TFM) de Prevención de Riesgos Laborales, Especialidad de Ergonomía y Psicosociología, y pretende plasmar los conocimientos teóricos adquiridos durante el curso realizando una Evaluación Ergonómica y Psicosocial de puestos de trabajo con Pantallas de Visualización de Datos (PVD), y demostrar que los métodos utilizados, el del Instituto Nacional de Seguridad e Higiene en el Trabajo (INSHT) para la evaluación ergonómica y el CoPsoQ I...

  14. Vitamin D supplementation for cystic fibrosis.

    Science.gov (United States)

    Ferguson, Janet H; Chang, Anne B

    2014-05-14

    Cystic fibrosis (CF) is a genetic disorder with multiorgan effects. In a subgroup with pancreatic insufficiency malabsorption of the fat soluble vitamins (A, D, E, K) may occur. Vitamin D is involved in calcium homeostasis and bone mineralisation and may have extraskeletal effects. This review examines the evidence for vitamin D supplementation in cystic fibrosis. To assess the effects of vitamin D supplementation on the frequency of vitamin D deficiency, respiratory outcomes and vitamin D toxicity in the cystic fibrosis population. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Date of the most recent search: 08 July 2013. Randomised and quasi-randomised controlled studies of vitamin D supplementation compared to placebo in the cystic fibrosis population regardless of exocrine pancreatic function. Both authors independently assessed the risk of bias of each included study and extracted outcome data (from published study information) for assessment of bone mineralization, growth and nutritional status, frequency of vitamin D deficiency, respiratory status, quality of life and adverse events. Six studies (239 participants) are included, although only three studies provided data from 69 adults and children with cystic fibrosis for analysis. One study compared a single high dose of vitamin D (250,000 IU) to placebo at the time of hospital admission with a respiratory exacerbation in 30 pancreatic insufficient adults with cystic fibrosis. The second study compared supplemental 800 international units (IU) vitamin D and placebo for 12 months in 30 osteopenic pancreatic insufficient adults; both groups continued 900 IU vitamin D daily. The third study compared supplemental 1 g calcium alone, 1600 IU vitamin D alone, 1600 IU vitamin D and 1 g calcium and placebo in a double

  15. El Derecho del Trabajo y su relación con el Derecho Civil ¿El ocaso de la especialidad del Derecho del Trabajo?

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    Cristina Mangarelli

    2010-07-01

    Full Text Available En este trabajo se analizarán las relaciones entre el derecho del trabajo y el civil partiendo de la consideración del derecho del trabajo como derecho especial (y autónomo, que no impide recurrir en forma supletoria al derecho civil para llenar vacíos en la norma laboral.El recurso el derecho civil en caso de lagunas, ha permitido desarrollar y acentuar los particularismos del derecho del trabajo, mediante la creación de figuras laborales basadas en normas civiles, limitar los poderes del empleador (por ejemplo, invocando el deber de obrar de buena fe en la ejecución del contrato, ampliar el campo de la responsabilidad patronal (despido abusivo.Si bien el moderno derecho civil ha comenzado a utilizar algunos conceptos similares a los del derecho del trabajo (protección del contratante débil, nulidad de cláusulas abusivas, etc., ello no ha implicado un debilitamiento de las fronteras.En Ios últimos años, una corriente laboral postula la aplicación de conceptos generales extraídos del derecho civil (o del derecho común aún en casos en los que no existe vacío en la norma laboral, lo cual resulta improcedente teniendo en cuenta que la norma especial deroga la general, y pone en crisis la especialidad del derecho del trabajo.

  16. Datos normativos para el test de Span Visual: estudio evolutivo de la memoria de trabajo visual y la memoria de trabajo verbal

    Directory of Open Access Journals (Sweden)

    Sergio Hernández

    2012-06-01

    Full Text Available El objetivo central del presente trabajo ha sido la baremación en una amplia muestra de población infantil de una prueba destinada a la evaluación de la memoria de trabajo visual. Además, hemos abordado el estudio del desarrollo evolutivo de la memoria de trabajo verbal y la memoria de trabajo visual. Se seleccionó a una muestra de 1.030 sujetos con edades comprendidas entre los 6 años y 3 meses y los 12 años y 4 meses que cursaban entre primero y sexto de educación primaria. Las pruebas utilizadas fueron: el Span Visual de la Wechsler Memory Scale, tanto en su versión directa como inversa, para la memoria de trabajo visual y la adaptación al español de la prueba de Memoria de Frases de Siegel y Ryan para la memoria de trabajo verbal. Los resultados encontrados ponen de manifiesto una mejora progresiva en el rendimiento en función de la edad en ambas pruebas. Se presentan tablas de medias, desviación estándar y percentiles para los distintos grupos de edad. Estos datos podrán ser utilizados como referencia normativa por aquellos profesionales interesados en el estudio del funcionamiento ejecutivo de la población escolar infantil.

  17. Current Strategies for Quantitating Fibrosis in Liver Biopsy

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    Yan Wang

    2015-01-01

    Full Text Available Objective: The present mini-review updated the progress in methodologies based on using liver biopsy. Data Sources: Articles for study of liver fibrosis, liver biopsy or fibrosis assessment published on high impact peer review journals from 1980 to 2014. Study Selection: Key articles were selected mainly according to their levels of relevance to this topic and citations. Results: With the recently mounting progress in chronic liver disease therapeutics, comes by a pressing need for precise, accurate, and dynamic assessment of hepatic fibrosis and cirrhosis in individual patients. Histopathological information is recognized as the most valuable data for fibrosis assessment. Conventional histology categorical systems describe the changes of fibrosis patterns in liver tissue; but the simplified ordinal digits assigned by these systems cannot reflect the fibrosis dynamics with sufficient precision and reproducibility. Morphometric assessment by computer assist digital image analysis, such as collagen proportionate area (CPA, detects change of fibrosis amount in tissue section in a continuous variable, and has shown its independent diagnostic value for assessment of advanced or late-stage of fibrosis. Due to its evident sensitivity to sampling variances, morphometric measurement is feasible to be taken as a reliable statistical parameter for the study of a large cohort. Combining state-of-art imaging technology and fundamental principle in Tissue Engineering, structure-based quantitation was recently initiated with a novel proof-of-concept tool, qFibrosis. qFibrosis showed not only the superior performance to CPA in accurately and reproducibly differentiating adjacent stages of fibrosis, but also the possibility for facilitating analysis of fibrotic regression and cirrhosis sub-staging. Conclusions: With input from multidisciplinary innovation, liver biopsy assessment as a new "gold standard" is anticipated to substantially support the accelerated

  18. The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis

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    Lucy A. Murtha

    2017-10-01

    Full Text Available Fibrosis is the formation of fibrous connective tissue in response to injury. It is characterized by the accumulation of extracellular matrix components, particularly collagen, at the site of injury. Fibrosis is an adaptive response that is a vital component of wound healing and tissue repair. However, its continued activation is highly detrimental and a common final pathway of numerous disease states including cardiovascular and respiratory disease. Worldwide, fibrotic diseases cause over 800,000 deaths per year, accounting for ~45% of total deaths. With an aging population, the incidence of fibrotic disease and subsequently the number of fibrosis-related deaths will rise further. Although, fibrosis is a well-recognized cause of morbidity and mortality in a range of disease states, there are currently no viable therapies to reverse the effects of chronic fibrosis. Numerous predisposing factors contribute to the development of fibrosis. Biological aging in particular, interferes with repair of damaged tissue, accelerating the transition to pathological remodeling, rather than a process of resolution and regeneration. When fibrosis progresses in an uncontrolled manner, it results in the irreversible stiffening of the affected tissue, which can lead to organ malfunction and death. Further investigation into the mechanisms of fibrosis is necessary to elucidate novel, much needed, therapeutic targets. Fibrosis of the heart and lung make up a significant proportion of fibrosis-related deaths. It has long been established that the heart and lung are functionally and geographically linked when it comes to health and disease, and thus exploring the processes and mechanisms that contribute to fibrosis of each organ, the focus of this review, may help to highlight potential avenues of therapeutic investigation.

  19. Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients

    DEFF Research Database (Denmark)

    Fluge, Gjermund; Olesen, Hanne Vebert; Giljam, Marita

    2009-01-01

    Background: The co-morbidity of cystic fibrosis (CF) and celiac disease (CD) has been reported sporadically since the 1960s. To our knowledge, this is the first time a systematic screening is performed in a large cohort of CF patients. Methods: Transglutaminase-IgA (TGA), endomysium-IgA (EMA...

  20. Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients

    DEFF Research Database (Denmark)

    Fluge, G; Olesen, H V; Gilljam, M

    2009-01-01

    BACKGROUND: The co-morbidity of cystic fibrosis (CF) and celiac disease (CD) has been reported sporadically since the 1960s. To our knowledge, this is the first time a systematic screening is performed in a large cohort of CF patients. METHODS: Transglutaminase-IgA (TGA), endomysium-IgA (EMA...

  1. Fibrosis of Two: Epithelial Cell-Fibroblast Interactions in Pulmonary Fibrosis

    Science.gov (United States)

    Sakai, Norihiko; Tager, Andrew M.

    2013-01-01

    Idiopathic pulmonary fibrosis (IPF) is characterized by the progressive and ultimately fatal accumulation of fibroblasts and extracellular matrix in the lung that distorts its architecture and compromises its function. IPF is now thought to result from wound-healing processes that, although initiated to protect the host from injurious environmental stimuli, lead to pathological fibrosis due to these processes becoming aberrant or over-exuberant. Although the environmental stimuli that trigger IPF remain to be identified, recent evidence suggests that they initially injure the alveolar epithelium. Repetitive cycles of epithelial injury and resultant alveolar epithelial cell death provoke the migration, proliferation, activation and myofibroblast differentiation of fibroblasts, causing the accumulation of these cells and the extracellular matrix that they synthesize. In turn, these activated fibroblasts induce further alveolar epithelial cell injury and death, thereby creating a vicious cycle of pro-fibrotic epithelial cell-fibroblast interactions. Though other cell types certainly make important contributions, we focus here on the “pas de deux” (steps of two), or perhaps more appropriate to IPF pathogenesis, the “folie à deux” (madness of two) of epithelial cells and fibroblasts that drives the progression of pulmonary fibrosis. We describe the signaling molecules that mediate the interactions of these cell types in their “fibrosis of two”, including transforming growth factor-β, connective tissue growth factor, sonic hedgehog, prostaglandin E2, angiotensin II and reactive oxygen species. PMID:23499992

  2. Tiempo máximo aceptable de trabajo para tareas ejecutadas con miembros superiores e inferiores

    Directory of Open Access Journals (Sweden)

    Juan C. Velásquez V.

    2015-12-01

    Full Text Available Introducción: La carga física de trabajo es uno de los principales factores de riesgo a los que se enfrentan los trabajadores. En la actualidad los métodos propuestos para evaluar la carga física dinámica contemplan el trabajo con todo el cuerpo y no discriminan por segmentos corporales. Objetivo: Determinar el tiempo máximo aceptable de trabajo cuando el trabajo se ejecuta con todo el cuerpo, con los miembros superiores o los miembros inferiores. Métodos: Se realizó medición de consumo de oxígeno mediante ergoespirometria y monitorización de la frecuencia cardiaca en 30 trabajadores expuestos a diversas cargas ejecutadas con todo el cuerpo, miembros inferiores y miembros superiores. Se determinó el umbral anaeróbico por coeficiente respiratorio, el cual sirvió de base para de determinación del tiempo máximo aceptable de trabajo. Resultados: Los tiempos máximos aceptables de trabajo fueron similares para tareas con todo el cuerpo y con miembros inferiores, pero significativamente menores para tareas realizadas con miembros superiores. Se halló un modelo de correlación exponencial negativo entre en tiempo de trabajo, el consumo de oxígeno, y la frecuencia cardiaca, R > 0,9 en todos los casos. Se plantearon 9 ecuaciones de regresión para determinar el tiempo máximo aceptable de trabajo. Conclusiones: El tiempo máximo aceptable de trabajo para miembros inferiores y para todo el cuerpo se comportan de manera similar. El tiempo máximo aceptables de trabajo con miembros superiores es significativamente inferior a los anteriores. La frecuencia cardiaca relativa parece ser el mejor indicador para medir el tiempo máximo aceptables de trabajo en campo.

  3. Microbiological surveillance in patients with cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Paola Gualdi

    2010-06-01

    Full Text Available Pulmonary infections in patients with cystic fibrosis (CF, are a major cause of morbidity and mortality. Prevention, diagnosis and therapy in cystic fibrosis, lead to the necessary collaboration between clinical and laboratory to identify effective strategies and appropriate solutions to address the problems inherent isolation micro-organisms, antibiotic strategies, overcoming of bacterial resistance and other problems management of these patients. The task of the microbiology laboratory and research in quickly and accurately, the agents responsible for these infectious processes, in order to isolate them from material, identify and determine their sensitivity antibiotics. A microbiological surveillance on 34 patients (13 males and 21 females with CF and related to the “Support Services Provincial Trento for the treatment of cystic fibrosis “in the period July 2005 - August 2008, was carried out. 180 Gram positive and 278 of Gram negative bacteria as well as 235 fungi wre collected. Staphylococcus aureus was the most frequently organism found in patients with CF with an incidence of 23% on 156 strains isolated, Pseudomonas aeruginosa was collected 19% of all microorganisms isolated corresponding to 131 strains, Candida albicans is the yeast often isolated with a frequency 22% equal to 149 isolates, Aspergillus fumigatus was isolated at a rate of 8%. From the data we collected and processed has been noted that the local epidemiology of CF patients reflects as reported in the scientific literature and national international consulting, both as a type microorganisms that frequency also isolated compared to age groups. Considering the score of Bartlett as discriminating respiratory fitness of the material, it has been observed that only 32 samples over 327 total (10% would materials insignificant. It follows therefore that the time of sample collection, followed by personnel (physiotherapists dedicated to CF patients, represents a crucial step

  4. Cystic Fibrosis Revisited - a Review Study.

    Science.gov (United States)

    Klimova, Blanka; Kuca, Kamil; Novotny, Michal; Maresova, Petra

    2017-01-01

    Cystic fibrosis (CF) is an incurable, chronic disease, which causes severe damages to respiratory and digestive tracts. It is the most common genetically inherited disease among caucasians. This disease is caused by defects in CF genes, the so-called mutations in cystic fibrosis transmembrane conductance regulator (CFTR) gene population. At present over 100,000 people suffer from this disease worldwide. The purpose of this review study is to describe the pathophysiology of CF and provide the latest information on its diagnosis and treatment therapies with respect to the improvement of patient's quality of life and emphasis on targeted specialized care. The methodological approaches include a method of literature review of available sources exploring the issue of cystic fibrosis both from a global and specific perspective point of view. A search was performed in the databases PubMed, MEDLINE, Web of Science, Scopus, Springer and ScienceDirect. Furthermore, other sources cited in the analyzed studies were also examined. On the basis of evaluation of these literature sources, the research issue was explored. The main benefits (e.g., specialized centres for the treatment of CF exist or a new breakthrough in the gene therapy of CF has been made) and limitations (e.g., comorbidity of CF, lifelong and costly treatment, or adverse impact on patient's and caregiver's quality of life) in the treatment of narcolepsy are highlighted. CF requires an integrated treatment approach in specialized CF centers, involving various factors contributing to a better patient's state of health in the form of relevant and well-balanced non-pharmacological and pharmacological therapies. In addition, further large scale clinical trials are needed in order to develop compounds that are aimed at the most common classes of CFTR. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  5. Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis.

    Directory of Open Access Journals (Sweden)

    Eric Lefebvre

    Full Text Available Interactions between C-C chemokine receptor types 2 (CCR2 and 5 (CCR5 and their ligands, including CCL2 and CCL5, mediate fibrogenesis by promoting monocyte/macrophage recruitment and tissue infiltration, as well as hepatic stellate cell activation. Cenicriviroc (CVC is an oral, dual CCR2/CCR5 antagonist with nanomolar potency against both receptors. CVC's anti-inflammatory and antifibrotic effects were evaluated in a range of preclinical models of inflammation and fibrosis.Monocyte/macrophage recruitment was assessed in vivo in a mouse model of thioglycollate-induced peritonitis. CCL2-induced chemotaxis was evaluated ex vivo on mouse monocytes. CVC's antifibrotic effects were evaluated in a thioacetamide-induced rat model of liver fibrosis and mouse models of diet-induced non-alcoholic steatohepatitis (NASH and renal fibrosis. Study assessments included body and liver/kidney weight, liver function test, liver/kidney morphology and collagen deposition, fibrogenic gene and protein expression, and pharmacokinetic analyses.CVC significantly reduced monocyte/macrophage recruitment in vivo at doses ≥20 mg/kg/day (p < 0.05. At these doses, CVC showed antifibrotic effects, with significant reductions in collagen deposition (p < 0.05, and collagen type 1 protein and mRNA expression across the three animal models of fibrosis. In the NASH model, CVC significantly reduced the non-alcoholic fatty liver disease activity score (p < 0.05 vs. controls. CVC treatment had no notable effect on body or liver/kidney weight.CVC displayed potent anti-inflammatory and antifibrotic activity in a range of animal fibrosis models, supporting human testing for fibrotic diseases. Further experimental studies are needed to clarify the underlying mechanisms of CVC's antifibrotic effects. A Phase 2b study in adults with NASH and liver fibrosis is fully enrolled (CENTAUR Study 652-2-203; NCT02217475.

  6. Protective role of NKT cells and macrophage M2-driven phenotype in bleomycin-induced pulmonary fibrosis.

    Science.gov (United States)

    Grabarz, Felipe; Aguiar, Cristhiane Favero; Correa-Costa, Matheus; Braga, Tárcio Teodoro; Hyane, Meire I; Andrade-Oliveira, Vinícius; Landgraf, Maristella Almeida; Câmara, Niels Olsen Saraiva

    2018-04-01

    Pulmonary fibrosis is a result of an abnormal wound healing in lung tissue triggered by an excessive accumulation of extracellular matrix proteins, loss of tissue elasticity, and debit of ventilatory function. NKT cells are a major source of Th1 and Th2 cytokines and may be crucial in the polarization of M1/M2 macrophages in pulmonary fibrogenesis. Although there appears to be constant scientific progress in that field, pulmonary fibrosis still exhibits no current cure. From these facts, we hypothesized that NKT cells could influence the development of pulmonary fibrosis via modulation of macrophage activation. Wild type (WT) and NKT type I cell-deficient mice (Jα18 -/- ) were subjected to the protocol of bleomycin-induced pulmonary fibrosis with or without treatment with NKT cell agonists α-galactosylceramide and sulfatide. The participation of different cell populations, collagen deposition, and protein levels of different cytokines involved in inflammation and fibrosis was evaluated. The results indicate a benign role of NKT cells in Jα18 -/- mice and in wild-type α-galactosylceramide-sulfatide-treated groups. These animals presented lower levels of collagen deposition, fibrogenic molecules such as TGF-β and vimentin and improved survival rates. In contrast, WT mice developed a Th2-driven response augmenting IL-4, 5, and 13 protein synthesis and increased collagen deposition. Furthermore, the arginase-1 metabolic pathway was downregulated in wild-type NKT-activated and knockout mice indicating lower activity of M2 macrophages in lung tissue. Hence, our data suggest that NKT cells play a protective role in this experimental model by down modulating the Th2 milieu, inhibiting M2 polarization and finally preventing fibrosis.

  7. Crisis, ingresos y mercado de trabajo en Ecuador

    Directory of Open Access Journals (Sweden)

    2002-01-01

    Full Text Available Au court des dernières qannées, l'Équateur a traversé une profonde crise économique et politique. Les indicateurs d'inégalité, dont les déterminants sont sanalysés à fond dans ce travail, montrent des changements entre 1995 et 1998. Les données indiquent que les facteurs les plus significatifs qui expliquent l'inégalité sont : la scolarité, l'appartenance au secteur agricole, le sexe et le degré de formalité de l'emploi. En désagrégant ces caracteristiques de l'e´chantillon, les différentes contributions de chaque facteur à l'inégalité se manifestent. La raison pourrait en être les changements survenus dans la structure productive de la famille, parmi lesqueles se trouvent la participation des femmes et le phénomène migratoire, qui s'est accentué depuis 1998. Ecuador ha atravesado una profunda crisis económica y política los últimos años. Los indicadores de desigualdad, cuyos determinantes se analizan con profundidad en este trabajo, muestran variaciones entre 1995 y 1998. La evidencia indica que los factores más significativos para explicar la desigualdad son la escolaridad, la pertenencia al sector agrícola, el género y el grado de formalidad del empleo. Al desagregar la muestra por estas características, se encuentran diferencias en la forma en que cada uno de estos factores contribuyen a la desigualdad. La explicación se encontraría en que se han dado cambios en la estructura productiva de la familia, entre los cuales destacan la forma de participación de la mujer y un proceso migratorio al extranjero que se aceleró justamente a partir de 1998. In recent years, Ecuador has gone through a severe economic and political crisis. Inequality indicators for the 1995-1998 period, which are analized in depth in this paper, exhibit a rising trend. The evidence indicates that the most significant factors that contribute to inequality are education, belonging to the agricultural sector, gender, and the degree of

  8. Vitamin K supplementation for cystic fibrosis.

    Science.gov (United States)

    Jagannath, Vanitha A; Thaker, Vidhu; Chang, Anne B; Price, Amy I

    2017-08-22

    Cystic fibrosis is a genetic disorder which can lead to multiorgan dysfunction. Malabsorption of fat and fat-soluble vitamins (A, D, E, K) may occur and can cause subclinical deficiencies of some of these vitamins. Vitamin K is known to play an important role in both blood coagulation and bone formation. Supplementation with vitamin K appears to be one way of addressing the deficiency, but there is very limited agreement on the appropriate dose and frequency of use of these supplements. This is an updated version of the review. To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Register comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Most recent search: 30 January 2017. Randomised and quasi-randomised controlled trials of all preparations of vitamin K used as a supplement compared to either no supplementation (or placebo) at any dose or route and for any duration, in children or adults diagnosed with cystic fibrosis (by sweat test or genetic testing). Two authors independently screened papers, extracted trial details and assessed their risk of bias. Two trials (total of 32 participants) each lasting one month were included in the review and were assessed as having a moderate risk of bias. One was a dose-ranging parallel group trial in children (aged 8 to 18 years); and the other (with an older cohort) had a cross-over design comparing supplements to no treatment, but no separate data were reported for the first intervention period. Neither of the trials addressed any of the primary outcomes (coagulation, bone formation and quality of life). Both trials reported the restoration of serum vitamin K and undercarboxylated osteocalcin

  9. Cystic Fibrosis Diagnosis and Newborn Screening.

    Science.gov (United States)

    Rosenfeld, Margaret; Sontag, Marci K; Ren, Clement L

    2016-08-01

    The diagnosis of cystic fibrosis (CF) has evolved over the past decade as newborn screening has become universal in the United States and elsewhere. The heterogeneity of phenotypes associated with CF transmembrane conductance regulator (CFTR) dysfunction and mutations in the CFTR gene has become clearer, ranging from classic pancreatic-insufficient CF to manifestations in only 1 organ system to indeterminate diagnoses identified by newborn screening. The tools available for diagnosis have also expanded. This article reviews the newest diagnostic criteria for CF, newborn screening, prenatal screening and diagnosis, and indeterminate diagnoses in newborn-screened infants and symptomatic adults. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. CYSTIC FIBROSIS: MICROBIOLOGY AND HOST RESPONSE

    Science.gov (United States)

    Zemanick, Edith T.

    2016-01-01

    THE EARLIEST DESCRIPTIONS OF LUNG DISEASE IN PEOPLE WITH CYSTIC FIBROSIS (CF) DEMONSTRATED THE INVOLVEMENT OF THREE INTERACTING PATHOPHYSIOLOGICAL ELEMENTS IN CF AIRWAYS: MUCUS OBSTRUCTION, INFLAMMATION, AND INFECTION. OVER THE PAST 7 DECADES, OUR UNDERSTANDING OF CF RESPIRATORY MICROBIOLOGY AND INFLAMMATION HAS EVOLVED WITH THE INTRODUCTION OF NEW TREATMENTS, WITH INCREASED LONGEVITY, AND WITH INCREASINGLY SOPHISTICATED LABORATORY TECHNIQUES. IN THIS CHAPTER, WE WILL REVIEW THE CURRENT STATE OF UNDERSTANDING OF THE ROLES OF INFECTION AND INFLAMMATION AND THEIR ROLES IN DRIVING LUNG DISEASE. WE WILL ALSO DISCUSS HOW THIS CONSTANTLY EVOLVING INFORMATION IS USED TO INFORM CURRENT THERAPEUTIC STRATEGIES, MEASURES AND PREDICTORS OF DISEASE SEVERITY, AND RESEARCH PRIORITIES. PMID:27469179

  11. [Cystic fibrosis: centers and care networks organization].

    Science.gov (United States)

    Bellon, G

    2012-05-01

    More than 20 years after the gene discovery, without specific treatment, the observed improvement of the cystic fibrosis prognosis appears due to management's organization as well as early diagnosis (neonatal screening) or progress in symptomatic treatment. The CF Centers (CRCM) official recognition was a necessary step before generalization of routine neonatal screening (October, 2002). Actually French CF management relies on three levels of organization: CF centers, regional care networks and French CF Society, in close relationship with patients association (Vaincre la Mucoviscidose). Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  12. [Measurement of pulmonary inflammation in cystic fibrosis].

    Science.gov (United States)

    Fayon, M; Chiron, R; Abely, M

    2008-06-01

    Lung inflammation is a pivotal phenomenon in the pathogenesis of cystic fibrosis. Inflammation can be measured and quantified within a research perspective, as well as in daily clinical practice. In this review paper, the "Inflammation Task Force" of the "Société Française de Mucoviscidose" has reviewed the literature regarding the various techniques currently available (bronchoalveolar lavage, sputum analysis, nasal wash and brushing, exhaled breath condensates, carbon monoxide and nitric oxide, and systemic measurements (plasma and urine)). The interpretation of all these determinations in children and adults is also discussed.

  13. FIBROSIS PROGRESIVA DEL CUÁDRICEPS

    Directory of Open Access Journals (Sweden)

    Enrique Vergara Amador

    2011-04-01

    Discusión. El vasto intermedio ha sido utilizado para aplicación de medicamentos. Se tiene evidencia que esta porción muscular tiene una pobre perfusión sanguínea en niños. No se conoce aún exactamente la fisiopatología de la fibrosis. Muchos niños son mal diagnosticados, confundiéndolos con patologías articulares y reciben equivocadamente otros tipos de cirugías.

  14. [Nutritional management of cystic fibrosis in children].

    Science.gov (United States)

    Anton, Dana-Teodora; Moraru, D

    2010-01-01

    Children with cystic fibrosis (CF) are at risk for poor growth. A major goal in the management of CF patients is to maintain a good nutritional status as it improves long-term survival. A balanced diet, which includes adequate calories and the right vitamin and mineral supplements, is key to good nutrition and health. The authors present the improvements in management of nutrition that have occurred, particularly over the past 20 years. They also present the dietetic reccomandations for each group of age.

  15. Non invasive assessment of liver fibrosis in chronic hemodialysis ...

    African Journals Online (AJOL)

    The liver biopsy has long been the "gold standard" for assessing liver fibrosis in patients with hepatitis C. It's an invasive procedure which is associated with an elevated bleeding, especially in chronic hemodialysis patients. Main goal is to assess liver fibrosis in chronic hemodialysis with HCV by Fibroscan and by biological ...

  16. Increased alveolar soluble Annexin V promotes lung inflammation and fibrosis

    OpenAIRE

    Buckley, S.; Shi, W.; Xu, W.; Frey, M.R.; Moats, R.; Pardo, A.; Selman, M.; Warburton, D.

    2015-01-01

    The causes underlying the self-perpetuating nature of idiopathic pulmonary fibrosis (IPF), a progressive and usually lethal disease, remain unknown. We hypothesized that alveolar soluble Annexin V contributes to lung fibrosis, based on the observation that human IPF BALF containing high Annexin V levels promoted fibroblast involvement in alveolar epithelial wound healing that was reduced when Annexin V was depleted from the BALF.

  17. Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats

    Directory of Open Access Journals (Sweden)

    Lili eGao

    2015-10-01

    Full Text Available Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that lacks effective therapies at present. Glycyrrhizic acid (GA, a natural compound extracted from a traditional Chinese herbal medicine Glycyrrhiza glabra, was recently reported to benefit lung injury and liver fibrosis in animal models, yet whether GA has a therapeutic effect on pulmonary fibrosis is unknown. In this study, we investigated the potential therapeutic effect of GA on pulmonary fibrosis in a rat model with bleomycin (BLM-induced pulmonary fibrosis. The results indicated that GA treatment remarkably ameliorated BLM-induced pulmonary fibrosis and attenuated BLM-induced inflammation, oxidative stress, epithelial-mesenchymal transition and activation of tansforming growth factor-beta signaling pathway in the lungs. Further, we demonstrated that GA treatment inhibited proliferation of 3T6 fibroblast cells, induced cell cycle arrest and promoted apoptosis in vitro, implying that GA-mediated suppression of fibroproliferation may contribute to the anti-fibrotic effect against BLM-induced pulmonary fibrosis. In summary, our study suggests a therapeutic potential of GA in the treatment of pulmonary fibrosis.

  18. Typing of Pseudomonas aeruginosa strains in Norwegian cystic fibrosis patients

    DEFF Research Database (Denmark)

    Fluge, G; Ojeniyi, B; Høiby, N

    2001-01-01

    OBJECTIVES: Typing of Pseudomonas aeruginosa isolates from Norwegian cystic fibrosis (CF) patients with chronic Pseudomonas lung infection in order to see whether cross-infection might have occurred. METHODS: Isolates from 60 patients were collected during the years 1994-98, and typed by pulsed...... between cystic fibrosis patients has occurred....

  19. Uptake of genetic counselling services by patients with cystic fibrosis ...

    African Journals Online (AJOL)

    2011-05-09

    May 9, 2011 ... Original Research: Uptake of genetic counselling services by patients with cystic fibrosis and their families. 250. Vol 54 No 3. S Afr Fam Pract 2012. Introduction. Cystic fibrosis (CF) is a chronic, inherited disorder that affects the respiratory tract, pancreas, gastrointestinal system, exocrine sweat glands, and ...

  20. Fibrosis: a structural modulator of Sinoatrial Node physiology and dysfunction

    Directory of Open Access Journals (Sweden)

    Thomas A Csepe

    2015-02-01

    Full Text Available Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN, the primary pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure characterized by clusters of specialized cardiomyocytes, enmeshed within strands of connective tissue or fibrosis. Intranodal fibrosis is emerging as an important modulator of structural and functional integrity of the SAN pacemaker complex. In adult human hearts, fatty tissue and fibrosis insulate the SAN from the hyperpolarizing effect of the surrounding atria while electrical communication between the SAN and right atrium is restricted to discrete SAN conduction pathways. The amount of fibrosis within the SAN is inversely correlated with heart rate, while age and heart size are positively correlated with fibrosis. Pathological upregulation of fibrosis within the SAN may lead to tachycardia-bradycardia arrhythmias and cardiac arrest, possibly due to SAN reentry and exit block, and is associated with atrial fibrillation, ventricular arrhythmias, heart failure and myocardial infarction. In this review, we will discuss current literature on the role of fibrosis in normal SAN structure and function, as well as the causes and consequences of SAN fibrosis upregulation in disease conditions.

  1. Addressing liver fibrosis with Liposomes targeted to hepatic stellate cells

    NARCIS (Netherlands)

    Adrian, Joanna E.; Poelstra, Klaas; Kamps, Jan A. A. M.

    2007-01-01

    Liver fibrosis is a chronic disease that results from hepatitis B and C infections, alcohol abuse or metabolic and genetic disorders. Ultimately, progression of fibrosis leads to cirrhosis, a stage of the disease characterized by failure of the normal liver functions. Currently, the treatment of

  2. Nephrogenic systemic fibrosis (NSF) and gadolinium-based contrast ...

    African Journals Online (AJOL)

    Nephrogenic systemic fibrosis (NSF), unknown before March 1997 and first described in 2000, is a systemic disorder characterised by widespread tissue fibrosis. The first known case occurred in 1997, after the use of gadolinium-based contrast agents (GBCAs) at high doses in patients with renal failure had become routine.

  3. Lung fibrosis in deceased HIV-infected patients with Pneumocystis ...

    African Journals Online (AJOL)

    2012-06-02

    Jun 2, 2012 ... Three had co-infection with cytomegalovirus (CMV), two of which had fibrosis present. There was no evidence of TB or other fungal infections. Conclusion. The high mortality seen in this cohort of PcP patients was due to intractable respiratory failure from interstitial lung fibrosis. Whereas the differential.

  4. The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis

    NARCIS (Netherlands)

    Murtha, Lucy A.; Schuliga, Michael J.; Mabotuwana, Nishani S.; Hardy, Sean A.; Waters, David W.; Burgess, Janette K.; Knight, Darryl A.; Boyle, Andrew J.

    2017-01-01

    Fibrosis is the formation of fibrous connective tissue in response to injury. It is characterized by the accumulation of extracellular matrix components, particularly collagen, at the site of injury. Fibrosis is an adaptive response that is a vital component of wound healing and tissue repair.

  5. Evolving strategies for liver fibrosis staging: Non-invasive assessment.

    Science.gov (United States)

    Stasi, Cristina; Milani, Stefano

    2017-01-14

    Transient elastography and the acoustic radiation force impulse techniques may play a pivotal role in the study of liver fibrosis. Some studies have shown that elastography can detect both the progression and regression of fibrosis. Similarly, research results have been analysed and direct and indirect serum markers of hepatic fibrosis have shown high diagnostic accuracy for advanced fibrosis/cirrhosis. The prognosis of different stages of cirrhosis is well established and various staging systems have been proposed, largely based on clinical data. However, it is still unknown if either non-invasive markers of liver fibrosis or elastography may contribute to a more accurate staging of liver cirrhosis, in terms of prognosis and fibrosis regression after effective therapy. In fact, not enough studies have shown both the fibrosis regression in different cirrhosis stages and the point beyond which the prognosis does not change - even in the event of fibrosis regression. Therefore, future studies are needed to validate non-invasive methods in predicting the different phases of liver cirrhosis.

  6. Historia reciente del trabajo y los trabajadores. Apuntes sobre lo tradicional y lo nuevo, lo que cambia y permanece en el mundo del trabajo

    Directory of Open Access Journals (Sweden)

    Roxana Albanesi

    2015-07-01

    Full Text Available Referirse al trabajo es hacer mención a un concepto complejo y multifacético. A su vez, los trabajadores constituyen un grupo social heterogéneo cuya ubicación en la estructura social es diversa. En este artículo se buscar reflexionar acerca de las características actuales del trabajo. Se presenta una breve reseña histórica que remite a las diferentes formas que asume la relación capital-trabajo en el tiempo para detenerse, con mayor profundidad, en las transformaciones ocurridas desde la crisis del capitalismo industrial hasta nuestros días. La reflexión acerca de lo que cambió y lo que permanece como tendencias en el mundo del trabajo depende de la periodización con que se aborde la cuestión. La evolución general del capitalismo muestra que la informalidad, la precariedad, la inestabilidad son condiciones clásicas del trabajo cuando se encuentra sujeto a mercados autorregulados. Las diferencias quedan claramente identificadas cuando se toma como referencia el período del Estado de Bienestar. Desde esta perspectiva temporal, la desigualdad de los ingresos entre diferentes ramas y al interior de un mismo grupo no constituye una novedad, pero sí lo son la degradación de las condiciones de trabajo y la desprotección social. En la historia reciente, esta situación es percibida por los trabajadores como un incremento de la vulnerabilidad y de los riesgos. El desempleo como realidad o como amenaza permanente, las condiciones flexibles del trabajo, el debilitamiento de la creencia en soluciones colectivas, la resignación social, la organización de estrategias individuales e individualistas, son rasgos distintivos de la historia reciente de los trabajadores.

  7. Temas de Física para Ingeniería: Trabajo y energía

    OpenAIRE

    Beléndez, Augusto; Pastor Antón, Carlos; Bernabeu, Guillermo

    1988-01-01

    Apuntes de Mecánica: "Trabajo y energía". Trabajo y potencia. Energía cinética, teorema de la energía cinética. Fuerzas conservativas, energía potencial. Energía potencial gravitatoria. Principio de conservación de la energía mecánica. Choques.

  8. Vaccines for preventing infection with Pseudomonas aeruginosa in cystic fibrosis

    DEFF Research Database (Denmark)

    Johansen, H.K.; Gøtzsche, Peter C.; Johansen, Helle Krogh

    2008-01-01

    BACKGROUND: Chronic pulmonary infection in cystic fibrosis results in progressive lung damage. Once colonisation of the lungs with Pseudomonas aeruginosa occurs, it is almost impossible to eradicate. Vaccines, aimed at reducing infection with Pseudomonas aeruginosa, have been developed. OBJECTIVES......: To assess the effectiveness of vaccination against Pseudomonas aeruginosa in cystic fibrosis. SEARCH STRATEGY: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register using the terms vaccines AND pseudomonas (last search May 2008) and PubMed using the terms vaccin* AND cystic...... fibrosis (last search May 2008). SELECTION CRITERIA: Randomised trials (published or unpublished) comparing Pseudomonas aeruginosa vaccines (oral, parenteral or intranasal) with control vaccines or no intervention in cystic fibrosis. DATA COLLECTION AND ANALYSIS: The authors independently selected trials...

  9. Antioxidant supplementation for lung disease in cystic fibrosis

    DEFF Research Database (Denmark)

    Ciofu, Oana; Lykkesfeldt, Jens

    2014-01-01

    BACKGROUND: Airway infection leads to progressive damage of the lungs in cystic fibrosis and oxidative stress has been implicated in the etiology. Supplementation of antioxidant micronutrients (vitamin E, vitamin C, ß-carotene and selenium) or glutathione may therefore potentially help maintain...... an oxidant-antioxidant balance. Current literature suggests a relationship between oxidative status and lung function. OBJECTIVES: To synthesize existing knowledge of the effect of antioxidants such as vitamin C, vitamin E, ß-carotene, selenium and glutathione in cystic fibrosis lung disease. SEARCH METHODS......: The Cochrane Cystic Fibrosis and Genetic Disorders Group's Cystic Fibrosis Trials Register and PubMed were searched using detailed search strategies. We contacted authors of included studies and checked reference lists of these studies for additional, potentially relevant studies.Last search of Cystic Fibrosis...

  10. Cystic fibrosis with normal sweat chloride concentration: case report

    Directory of Open Access Journals (Sweden)

    Silva Filho Luiz Vicente Ferreira da

    2003-01-01

    Full Text Available Cystic fibrosis is a genetic disease usually diagnosed by abnormal sweat testing. We report a case of an 18-year-old female with bronchiectasis, chronic P. aeruginosa infection, and normal sweat chloride concentrations who experienced rapid decrease of lung function and clinical deterioration despite treatment. Given the high suspicion ofcystic fibrosis, broad genotyping testing was performed, showing a compound heterozygous with deltaF508 and 3849+10kb C->T mutations, therefore confirming cystic fibrosis diagnosis. Although the sweat chloride test remains the gold standard for the diagnosis of cystic fibrosis, alternative diagnostic tests such as genotyping and electrophysiologic measurements must be performed if there is suspicion of cystic fibrosis, despite normal or borderline sweat chloride levels.

  11. Normal sweat chloride test does not rule out cystic fibrosis.

    Science.gov (United States)

    Başaran, Abdurrahman Erdem; Karataş-Torun, Nimet; Maslak, İbrahim Cemal; Bingöl, Ayşen; Alper, Özgül M

    2017-01-01

    Başaran AE, Karataş-Torun N, Maslak İC, Bingöl A, Alper ÖM. Normal sweat chloride test does not rule out cystic fibrosis. Turk J Pediatr 2017; 59: 68-70. A 5-month-old patient presented with complaints of fever and cough. He was hospitalized with the diagnosis of bronchopneumonia and pseudo-Bartter's syndrome. Patient was further investigated for diagnosis of cystic fibrosis. The chloride (Cl) level in sweat was determined within the normal range (25.1 mmol/L, 20.3 mmol/L). CFTR (Cystic Fibrosis Transmembrane Regulator gene; NM_000492.2) genotyping results were positive for p.E92K; p.F1052V mutations. The patient was diagnosed with cystic fibrosis. In our patient, with features of CF and normal sweat test, mutation analysis was helpful for the diagnosis of cystic fibrosis.

  12. Myocardial fibrosis in patients with myotonic dystrophy type 1

    DEFF Research Database (Denmark)

    Petri, Helle; Ahtarovski, Kiril Aleksov; Vejlstrup, Niels

    2014-01-01

    , and the association between myocardial fibrosis and abnormal findings on ECG, Holter-monitoring and echocardiography. METHODS: We selected 30 unrelated patients with DM1: 18 patients (10 men, mean age 51 years) with, and 12 patients (7 men, mean age 41 years) without abnormal findings on ECG and Holter-monitoring....... Patients were evaluated with medical history, physical examination, ECG, Holter-monitoring, echocardiography and CMR. RESULTS: Myocardial fibrosis was found in 12/30 (40%, 9 men). The presence of myocardial fibrosis was associated with the following CMR-parameters: increased left ventricular mass (median...... of myocardial fibrosis and abnormal findings on: ECG (p = 0.71), Holter-monitoring (p = 0.27) or echocardiographic measurements of left ventricular volumes, ejection fraction or global longitudinal strain (p = 0.18). CONCLUSION: Patients with DM1 had a high prevalence of myocardial fibrosis which...

  13. Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Inflammation and Fibrosis of Skeletal Muscles.

    Science.gov (United States)

    Alameddine, Hala S; Morgan, Jennifer E

    2016-11-29

    In skeletal muscles, levels and activity of Matrix MetalloProteinases (MMPs) and Tissue Inhibitors of MetalloProteinases (TIMPs) have been involved in myoblast migration, fusion and various physiological and pathological remodeling situations including neuromuscular diseases. This has opened perspectives for the use of MMPs' overexpression to improve the efficiency of cell therapy in muscular dystrophies and resolve fibrosis. Alternatively, inhibition of individual MMPs in animal models of muscular dystrophies has provided evidence of beneficial, dual or adverse effects on muscle morphology or function. We review here the role played by MMPs/TIMPs in skeletal muscle inflammation and fibrosis, two major hurdles that limit the success of cell and gene therapy. We report and analyze the consequences of genetic or pharmacological modulation of MMP levels on the inflammation of skeletal muscles and their repair in light of experimental findings. We further discuss how the interplay between MMPs/TIMPs levels, cytokines/chemokines, growth factors and permanent low-grade inflammation favor cellular and molecular modifications resulting in fibrosis.

  14. Pathogenesis pathways of idiopathic pulmonary fibrosis in bleomycin-induced lung injury model in mice.

    Science.gov (United States)

    Shi, Keyun; Jiang, Jianzhong; Ma, Tieliang; Xie, Jing; Duan, Lirong; Chen, Ruhua; Song, Ping; Yu, Zhixin; Liu, Chao; Zhu, Qin; Zheng, Jinxu

    2014-01-01

    Our objective was to investigate the pathogenesis pathways of idiopathic pulmonary fibrosis (IPF). Bleomycin (BLM) induced animal models of experimental lung fibrosis were used. CHIP assay was executed to find the link between Smad3 and IL-31, and the expressions of TGF-β1, Smad3, IL-31 and STAT1 were detected to find whether they were similar with each other. We found that in the early injury or inflammation of the animal model, BLM promoted the development of inflammation, leading to severe pulmonary fibrosis. Then the expression of TGF-β1 and Smad3 increased. Activated Smad3 bound to the IL-31 promoter region, followed by the activation of JAK-STAT pathways. The inhibitor of TGF-β1 receptor decreased the IL-31 expression and knocking-down of IL-31 also decreased the STAT1 expression. We conclude that there is a pathway of pathogenesis in BLM-induced mouse model that involves the TGF-β, IL-31 and JAKs/STATs pathway. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. TRABAJO SOCIAL Y CIENCIAS SOCIALES. PODER, FUNCIONALIZACIÓN Y SUBALTERNIDAD DE SABERES

    Directory of Open Access Journals (Sweden)

    Belén Lorente Molina

    2012-04-01

    Full Text Available La relación entre Trabajo Social y Ciencias Sociales es interpretada a partir de tres consideraciones: la imbricación entre poder, funcionalización y subalternidad en la producción de los saberes del Trabajo Social; las condiciones de gestación en la producción de su conocimiento, y las particulares miradas del Trabajo Social como aporte a la comprensión de las realidades contemporáneas. Estos procesos proporcionan claridad en orden a comprender la naturalización de la cierta exclusión científica y académica del Trabajo Social por parte de profesionales del Trabajo Social y de otras disciplinas.

  16. Abdominal manifestations of cystic fibrosis in children

    International Nuclear Information System (INIS)

    Chaudry, Gulraiz; Navarro, Oscar M.; Levine, Daniel S.; Oudjhane, Kamaldine

    2006-01-01

    Pulmonary complications remain the main cause of mortality in cystic fibrosis, but the presenting symptoms in children are often related to gastrointestinal or pancreaticobiliary disease. Furthermore, abdominal manifestations are now seen throughout childhood, from infancy to adolescence. The child might present in the neonatal period with meconium ileus or its attendant complications. The older child might present with distal intestinal obstruction syndrome or colonic stricture secondary to high doses of pancreatic enzyme replacement. Less-common gastrointestinal manifestations include intussusception, duodenitis and fecal impaction of the appendix. Most children also show evidence of exocrine pancreatic deficiency. Radiologically, the combination of fat deposition and pancreatic fibrosis leads to varying CT and MR appearances. A higher than normal incidence of pancreatic cysts and calcification is also seen. Decreased transport of water and chloride also increases the viscosity of bile, with subsequent obstruction of the biliary ductules. If extensive, this can progress to obstructive cirrhosis, portal hypertension and esophageal varices. Diffuse fatty infiltration, hypersplenism and gallstones are also commonly seen in these patients. We present a pictorial review of the radiological appearance of these abdominal manifestations. The conditions are dealt with individually, together with typical appearances in various imaging modalities. (orig.)

  17. Cystic fibrosis chronic rhinosinusitis: A comprehensive review

    Science.gov (United States)

    Chaaban, Mohamad R.; Kejner, Alexandra; Rowe, Steven M.

    2013-01-01

    Background: Advances in the care of patients with cystic fibrosis (CF) have improved pulmonary outcomes and survival. In addition, rapid developments regarding the underlying genetic and molecular basis of the disease have led to numerous novel targets for treatment. However, clinical and basic scientific research focusing on therapeutic strategies for CF-associated chronic rhinosinusitis (CRS) lags behind the evidence-based approaches currently used for pulmonary disease. Methods: This review evaluates the available literature and provides an update concerning the pathophysiology, current treatment approaches, and future pharmaceutical tactics in the management of CRS in patients with CF. Results: Optimal medical and surgical strategies for CF CRS are lacking because of a dearth of well-performed clinical trials. Medical and surgical interventions are supported primarily by level 2 or 3 evidence and are aimed at improving clearance of mucus, infection, and inflammation. A number of novel therapeutics that target the basic defect in the cystic fibrosis transmembrane conductance regulator channel are currently under investigation. Ivacaftor, a corrector of the G551D mutation, was recently approved by the Food and Drug Administration. However, sinonasal outcomes using this and other novel drugs are pending. Conclusion: CRS is a lifelong disease in CF patients that can lead to substantial morbidity and decreased quality of life. A multidisciplinary approach will be necessary to develop consistent and evidence-based treatment paradigms. PMID:24119602

  18. Imaging the Abdominal Manifestations of Cystic Fibrosis

    Directory of Open Access Journals (Sweden)

    C. D. Gillespie

    2017-01-01

    Full Text Available Cystic fibrosis (CF is a multisystem disease with a range of abdominal manifestations including those involving the liver, pancreas, and kidneys. Recent advances in management of the respiratory complications of the disease has led to a greater life expectancy in patients with CF. Subsequently, there is increasing focus on the impact of abdominal disease on quality of life and survival. Liver cirrhosis is the most important extrapulmonary cause of death in CF, yet significant challenges remain in the diagnosis of CF related liver disease. The capacity to predict those patients at risk of developing cirrhosis remains a significant challenge. We review representative abdominal imaging findings in patients with CF selected from the records of two academic health centres, with a view to increasing familiarity with the abdominal manifestations of the disease. We review their presentation and expected imaging findings, with a focus on the challenges facing diagnosis of the hepatic manifestations of the disease. An increased familiarity with these abdominal manifestations will facilitate timely diagnosis and management, which is paramount to further improving outcomes for patients with cystic fibrosis.

  19. Global impact of bronchiectasis and cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Margarida Redondo

    2016-09-01

    To understand variation in the aetiology, microbiology and burden of bronchiectasis and cystic fibrosis across different global healthcare systems.; Bronchiectasis is the term used to refer to dilatation of the bronchi that is usually permanent and is associated with a clinical syndrome of cough, sputum production and recurrent respiratory infections. It can be caused by a range of inherited and acquired disorders, or may be idiopathic in nature. The most well recognised inherited disorder in Western countries is cystic fibrosis (CF, an autosomal recessive condition that leads to progressive bronchiectasis, bacterial infection and premature mortality. Both bronchiectasis due to CF and bronchiectasis due to other conditions are placing an increasing burden on healthcare systems internationally. Treatments for CF are becoming more effective leading to more adult patients with complex healthcare needs. Bronchiectasis not due to CF is becoming increasingly recognised, particularly in the elderly population. Recognition is important and can lead to identification of the underlying cause, appropriate treatment and improved quality of life. The disease is highly diverse in its presentation, requiring all respiratory physicians to have knowledge of the different “bronchiectasis syndromes”. The most common aetiologies and presenting syndromes vary depending on geography, with nontuberculous mycobacterial disease predominating in some parts of North America, post-infectious and idiopathic disease predominating in Western Europe, and post-tuberculosis bronchiectasis dominating in South Asia and Eastern Europe. Ongoing global collaborative studies will greatly advance our understanding of the international impact of bronchiectasis and CF.

  20. Cystic Fibrosis and the Nervous System.

    Science.gov (United States)

    Reznikov, Leah R

    2017-05-01

    Cystic fibrosis (CF) is a life-shortening autosomal recessive disorder caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is an anion channel that conducts bicarbonate and chloride across cell membranes. Although defective anion transport across epithelial cells is accepted as the basic defect in CF, many of the features observed in people with CF and organs affected by CF are modulated by the nervous system. This is of interest because CFTR expression has been reported in both the peripheral and central nervous systems, and it is well known that the transport of anions, such as chloride, greatly modulates neuronal excitability. Thus it is predicted that in CF, lack of CFTR in the nervous system affects neuronal function. Consistent with this prediction, several nervous system abnormalities and nervous system disorders have been described in people with CF and in animal models of CF. The goal of this special feature article is to highlight the expression and function of CFTR in the nervous system. Special emphasis is placed on nervous system abnormalities described in people with CF and in animal models of CF. Finally, features of CF that may be modulated by or attributed to faulty nervous system function are discussed. Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

  1. Fibroblasts in fibrosis: novel roles and mediators

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    Ryan Thomas Kendall

    2014-05-01

    Full Text Available Fibroblasts are the most common cell type of the connective tissues found throughout the body and the principal source of the extensive extracellular matrix (ECM characteristic of these tissues. They are also the central mediators of the pathological fibrotic accumulation of ECM and the cellular proliferation and differentiation that occurs in response to prolonged tissue injury and chronic inflammation. The transformation of the fibroblast cell lineage involves classical developmental signaling programs and includes a surprisingly diverse range of precursor cell types—most notably, myofibroblasts that are the apex of the fibrotic phenotype. Myofibroblasts display exaggerated ECM production; constitutively secrete and are hypersensitive to chemical signals such as cytokines, chemokines, and growth factors; and are endowed with a contractile apparatus allowing them to manipulate the ECM fibers physically to close open wounds. In addition to ECM production, fibroblasts have multiple concomitant biological roles, such as in wound healing, inflammation, and angiogenesis, which are each interwoven with the process of fibrosis. We now recognize many common fibroblast-related features across various physiological and pathological protracted processes. Indeed, a new appreciation has emerged for the role of noncancerous fibroblast interactions with tumors in cancer progression. Although the predominant current clinical treatments of fibrosis involve nonspecific immunosuppressive and anti-proliferative drugs, a variety of potential therapies under investigation specifically target fibroblast biology.

  2. Abdominal manifestations of cystic fibrosis in children

    Energy Technology Data Exchange (ETDEWEB)

    Chaudry, Gulraiz; Navarro, Oscar M.; Levine, Daniel S.; Oudjhane, Kamaldine [University of Toronto, Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON (Canada)

    2006-03-15

    Pulmonary complications remain the main cause of mortality in cystic fibrosis, but the presenting symptoms in children are often related to gastrointestinal or pancreaticobiliary disease. Furthermore, abdominal manifestations are now seen throughout childhood, from infancy to adolescence. The child might present in the neonatal period with meconium ileus or its attendant complications. The older child might present with distal intestinal obstruction syndrome or colonic stricture secondary to high doses of pancreatic enzyme replacement. Less-common gastrointestinal manifestations include intussusception, duodenitis and fecal impaction of the appendix. Most children also show evidence of exocrine pancreatic deficiency. Radiologically, the combination of fat deposition and pancreatic fibrosis leads to varying CT and MR appearances. A higher than normal incidence of pancreatic cysts and calcification is also seen. Decreased transport of water and chloride also increases the viscosity of bile, with subsequent obstruction of the biliary ductules. If extensive, this can progress to obstructive cirrhosis, portal hypertension and esophageal varices. Diffuse fatty infiltration, hypersplenism and gallstones are also commonly seen in these patients. We present a pictorial review of the radiological appearance of these abdominal manifestations. The conditions are dealt with individually, together with typical appearances in various imaging modalities. (orig.)

  3. Imaging findings in congenital hepatic fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Akhan, Okan [Department of Radiology, Hacettepe University, School of Medicine, 06100 Ankara (Turkey)]. E-mail: akhano@tr.net; Karaosmanoglu, Ali Devrim [Department of Radiology, Hacettepe University, School of Medicine, 06100 Ankara (Turkey); Ergen, Bilge [Department of Radiology, Hacettepe University, School of Medicine, 06100 Ankara (Turkey)

    2007-01-15

    Congenital hepatic fibrosis (CHF) is a rare congenital multisystemic disorder, mostly inherited in autosomal recessive fashion, primarily affecting renal and hepatobiliary systems. Main underlying process of the disease is the malformation of the ductal plate, the embryological precursor of the biliary system, and secondary biliary strictures and periportal fibrosis ultimately leading to portal hypertension. The natural course of the disease is highly variable ranging from minimally symptomatic disease to true cirrhosis of the liver. However, in most patients the most common manifestations of the diseases that are related to portal hypertension, particularly splenomegaly and bleeding varices. Many other disease processes may co-exist with the disease including Caroli's disease, choledochal cysts and autosomal recessive polycystic kidney disease (ARPKD) reflecting the mulstisystemic nature of the disease. The associating biliary ductal disease led the authors to think that all these entities are a continuum and different reflections of the same underlying pathophysiological process. Although, conventional method of diagnosis of CHF is the liver biopsy the advent of imaging technologies and modalities, today, may permit the correct diagnosis in a non-invasive manner. Characteristic imaging features are generally present and recognition of these findings may obviate liver biopsy while preserving the diagnostic accuracy. In this article, it is aimed to increase the awareness of the practising radiologists to the imaging findings of this uncommon clinical disorder and trail the blaze for future articles relating to this issue.

  4. Cystic fibrosis mortality trends in France.

    Science.gov (United States)

    Bellis, Gil; Cazes, Marie-Hélène; Parant, Alain; Gaimard, Maryse; Travers, Cécile; Le Roux, Evelyne; Ravilly, Sophie; Rault, Gilles

    2007-05-01

    In 1992 France set up a national cystic fibrosis observatory (Observatoire national de la mucoviscidose, ONM) to monitor the state of health of patients on an annual basis. Using the ONM data, this study estimates the main indicators for life expectancy and assesses the total number of cystic fibrosis patients. The data for the years 1994 to 2003 are divided into 3-year periods. Life tables are drawn up for these periods, from which mean and median lengths of life are determined. Using the most recent life table, the number of births in 2003 and the incidence of the disease, the total population of patients can be estimated, assuming a stationary population. In 2001-2003, life expectancy at birth of patients registered with the ONM was 39.1 years and median length of life was 36.4 years. These results, substantially better than those of 1994-1996, are linked to improved conditions of patient inclusion in the ONM database, to improvements in their healthcare, but also to the limitations of the life tables. Based on the 2003 data, the total theoretical number of patients is 6490, and coverage by the ONM database is thus 63.2%. These provisional results demonstrate the need to convert the ONM observatory into a registry providing exhaustive coverage of all patients.

  5. Cystic Fibrosis Related Diabetes: A Case Report

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    Banu Aktaş Yılmaz

    2012-12-01

    Full Text Available The incidence of cystic fibrosis-related diabetes (CFRD has increased, since the life expectancy of cystic fibrosis (CF patients continues to improve. CFRD increases the mortality in patients, because of the negative impacts of CFRD on pulmonary functions. Knowledge of the pathogenesis and course of the disease is essential to administer the appropriate therapy. A thirty-one-year-old CFRD patient, who had hypoglycemia and weight loss under the calorie restriction diet and basal insulin therapy, was admitted to the Endocrinology Department for revision of her therapy. A high-calorie diet considering increased energy demand and multiple insulin injections according the carbohydrate counting were administered to the patient. She gained weight and target blood glucose levels were achieved as a result of this therapy. We present the first case with CFRD followed in our clinic with the review of the literature about the pathogenesis, course and therapy of this disease to draw attention to a special kind of diabetes, which we will encounter more frequently. Turk Jem 2012; 16: 74-8

  6. Airway inflammation in mild cystic fibrosis.

    Science.gov (United States)

    Eckrich, Jonas; Zissler, Ulrich M; Serve, Friederike; Leutz, Patricia; Smaczny, Christina; Schmitt-Grohé, Sabina; Fussbroich, Daniela; Schubert, Ralf; Zielen, Stefan; Eickmeier, Olaf

    2017-01-01

    Airway infection and inflammation play major roles in the progression of cystic fibrosis (CF) lung disease. In patients with mild disease, airway inflammation is a clinically relevant and often underdiagnosed feature. Lung function, sputum cell counts, and cytokine profiles in CF with mild disease might be different in patients with and without involvement of small airway disease (SAD). Patients with mild CF (n=32) and 22 healthy controls were enrolled in this study. Patients with CF were assigned to two groups: (1) patients without SAD (n=19, median age 12.3years, MEF 25 >50% predicted), and (2) patients with SAD (n=13 median age, 13.2years, MEF 25 inflammation compared to controls as indicated by elevated levels of sputum biomarkers like total cells, neutrophils, and IL6. Our study demonstrated that patients with CF with mild disease defined by lung function might be further endotyped according to their involvement of SAD. In patients with CF and SAD, airway neutrophilic inflammation is more pronounced and is in part distinct from that seen in patients without SAD. Copyright © 2016 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

  7. Cystic fibrosis microbiology: Advances in antimicrobial therapy.

    Science.gov (United States)

    Waters, Valerie; Smyth, Alan

    2015-09-01

    Much of the improvement in the survival of individuals with cystic fibrosis (CF) is due to advancements in antimicrobial treatments. New aerosolized antibiotic formulations have recently been introduced (such as inhaled aztreonam), and others are in development (inhaled levofloxacin and liposomal amikacin). Licensed dry powder formulations include tobramycin inhalation powder and dry powder colistimethate (available in Europe). Although inhaled antibiotics have the advantage of being able to deliver high intrapulmonary concentrations of drug, antimicrobial resistance can still develop and is a concern in CF. Antimicrobial resistance might be mitigated by using non-antibiotic treatments, antibiotic adjuvants, which have activity against bacteria. Examples include agents such as gallium, antimicrobial peptides and anti-biofilm compounds such as alginate oligosaccharides (OligoG) and garlic. Vaccination strategies and antibody therapy (IgY) against Pseudomonas aeruginosa have also been attempted to prevent initial infection with this organism in CF. Although aggressive and long-term use of antibiotics has been crucial in slowing lung function decline and improving survival in people with CF, it has added a significant burden of care and associated toxicities in these individuals. Careful surveillance and the use of preventative strategies for antibiotic related toxicity (such as nephrotoxicity and ototoxicity) are essential. Continued development of effective antimicrobial agents that can function in the conditions encountered in the CF lung, such as against bacterial biofilm growth and under anaerobic conditions, is needed. Copyright © 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

  8. Mi trabajo es mi vida. La incrustación de los mundos de la vida y del trabajo en empresas españolas

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    Hugo Valenzuela

    2015-01-01

    Full Text Available En base a 20 etnografías realizadas en empresas españolas, este texto analiza formas emergentes de imbricación entre los mundos del trabajo y la vida. Si a partir de la Revolución Industrial se da una tendencia a la autonomía del proceso de trabajo con respecto a los entornos vitales de los trabajadores, actualmente se observa una tendencia inversa en ciertas empresas. Esta rearticulación se produce en varios sentidos: a en el desvanecimiento de la frontera que separa el trabajo de la vida cotidiana; b en la reinserción de dimensiones afectivas en los procesos laborales; c en el fomento de la reciprocidad y la sociabilidad en el ámbito económico; y d en la producción de experiencias signifi cativas en el trabajo. ¿Nos hallamos ante una reconciliación emancipadora de la vida y el trabajo? O, por el contrario, ¿se trata de una colonización del mundo de la vida por el mundo productivo? Proponemos explorar una tercera vía de análisis, la de la modernidad reflexiva.

  9. AMPLIFICACIÓN EN EL TRABAJO: CONSTRUYENDO UNA FUERZA DE TRABAJO SOSTENIBLE A TRAVÉS DE INTERVENCIONES INDIVIDUALES DE PSICOLOGÍA POSITIVA

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    Pascale M. Le Blanc

    2016-09-01

    Full Text Available La sostenibilidad de la fuerza laboral es de vital importancia para la viabilidad y la ventaja competitiva de las organizaciones contemporáneas. Así, y en paralelo con el surgimiento de la Psicología Organizacional Positiva, las organizaciones han incrementado su interés en fomentar el bienestar psicológico positivo de sus empleados. En este trabajo, las intervenciones de amplificación –i-e. intervenciones que tienen como objetivo fomentar el bienestar positivo en el trabajo – se presentan como una herramienta valiosa para incrementar la sostenibilidad de la fuerza laboral. En la pasada década, se han desarrollado y probado la efectividad de algunas intervenciones realizadas en el contexto laboral centradas en la amplificación. En el presente trabajo, en primer lugar destacamos algunas precondiciones importantes para el éxito de las intervenciones y brevemente discutimos el proceso de intervención en sí mismo. A continuación, se presenta una revisión de los trabajos empíricos sobre las intervenciones de amplificación, centrándonos en intervenciones que tienen como objetivo fomentar el engagement en el trabajo de los empleados. La investigación futura debe centrarse en probar los efectos de este tipo de intervenciones sobre los resultados a nivel de equipo y a nivel organizacional.

  10. Betulinic acid attenuates renal fibrosis in rat chronic kidney disease model.

    Science.gov (United States)

    Sharma, Anshuk; Thakur, Richa; Lingaraju, Madhu C; Kumar, Dhirendra; Mathesh, Karikalan; Telang, Avinash G; Singh, Thakur Uttam; Kumar, Dinesh

    2017-05-01

    Most chronic kidney diseases (CKDs), regardless of the nature of the initial injury, progress to end-stage renal disease (ESRD) characterized by fibrosis with irreversible loss of tissue and function. Thus, improved and more effective therapies are critical. Betulinic acid (BA), a pentacyclic triterpene is a compound in the pipeline of anti-cancer drug development. It has been shown to a possess variety of beneficial effects in many disease conditions. However, its efficacy against CKD is yet to be explored. The present study was undertaken to investigate the effect of BA on renal fibrosis in the rat model of adenine-induced CKD. CKD rats gained significantly less weight during the experimental period when compared to control rats and BA treatment did not significantly increase the weight gain in CKD rats. CKD rats showed elevated levels of serum blood urea nitrogen (BUN), creatinine and uric acid along with increased levels of kidney injury markers such as cystatin C and neutrophil gelatinase-associated lipocalin (NGAL). Further, in comparison to control rats, kidney samples from CKD rats revealed increased profibrotic protein levels like transforming growth factor-beta (TGF-β), connective tissue growth factor (CTGF), fibronectin, collagen type I and hydroxyproline indicating a progressive fibrotic response. These data are further fortified by histological findings where kidney damage and fibrosis are clearly evident as dilatation of tubules, glomerular degeneration and vacuolation along with deposition of collagen fibers. However, the above-mentioned findings in CKD rats were significantly reversed by BA-treatment revealing its nephroprotective potential and anti-fibrotic activity. The biochemical mechanism of the nephroprotective and anti-fibrotic effect of BA in the adenine-induced CKD rats might be mediated by inhibition of pro-fibrotic protein production thereby hindering the kidney tissue damage along with improvement in kidney function. Thus, BA could be

  11. Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis.

    Science.gov (United States)

    Chung, Ki Wung; Jeong, Hyeong Oh; Lee, Bonggi; Park, Daeui; Kim, Dae Hyun; Choi, Yeun Ja; Lee, Eun Kyeong; Kim, Kyung Mok; Park, June Whoun; Yu, Byung Pal; Chung, Hae Young

    2017-01-31

    Chronic inflammation is a major contributor to age-related nephropathic changes, including renal fibrosis. In this study, various experimental paradigms were designed to delineate the role played by NF-κBIZ (also known as IκBζ) in age-associated renal fibrosis. Analyses based on RNA-sequencing findings obtained by next generation sequencing (NGS) revealed the upregulations of NF-κBIZ and of IL-6 and MCP-1 (both known to be regulated by NF-κBIZ) during aging. The up-regulation of NF-κBIZ in aged rat kidneys coincided with increased macrophage infiltration. In LPS-treated macrophages, oxidative stress was found to play a pivotal role in NF-κBIZ expression, suggesting age-related oxidative stress is associated with NF-κBIZ activation. Furthermore, these in vitro findings were confirmed in LPS-treated old rats, which showed higher levels of oxidative stress and NF-κBIZ in kidneys than LPS-treated young rats. Additional in vitro experiments using macrophages and kidney fibroblasts demonstrated NF-κBIZ and related cytokines participate in fibrosis. In particular, increased levels of NF-κBIZ-associated cytokines in macrophages significantly up-regulated TGF-β induced kidney fibroblast activation. Moreover, experiments with NF-κBIZ knocked down macrophages showed reduced TGF-β-induced kidney fibroblast activation. The findings of the present study provide evidence regarding an involvement of NF-κBIZ in age-associated progressive renal fibrosis and provides potential targets for its prevention.

  12. Immune thrombocytopenia is associated with persistently deranged fibrosis-related seromarker profiles but low bone marrow fibrosis grades

    DEFF Research Database (Denmark)

    Ghanima, Waleed; Boiocchi, Leonardo; Lee, Christina S.

    2018-01-01

    Bone marrow (BM) fibrosis is a potential side effect of thrombopoietin receptor agonist (TPO-RA) treatment. We aimed to investigate stromal seromarker profiles and growth factors in order to elucidate pathogenic and dynamic aspects of immune thrombocytopenia (ITP)-related BM fibrosis before...... and during TPO-RA treatment. Connective tissue metabolites [procollagen I and III peptides (PINP/PIIINP); hyaluronan (HYA), C-terminal-telopeptide (ICTP), and fibrosis-related growth factors (transforming growth factor-beta (TGF-beta), HGF, basic fibroblast growth factor)] were measured in blood samples...... acquired before initiation of TPO-RA and subsequently at 6-month intervals for up to 2 years. BM fibrosis was graded MF-0 in 8 (18%), MF-1 30 (65%), and MF-2 8 (18%) in the last available BM biopsy. In the 21 patients having more than one biopsy, the grade of fibrosis from the first to the last available...

  13. Leptospira Interrogans Induces Fibrosis in the Mouse Kidney through Inos-Dependent, TLR- and NLR-Independent Signaling Pathways

    Science.gov (United States)

    Fanton d'Andon, Martine; Quellard, Nathalie; Fernandez, Béatrice; Ratet, Gwenn; Lacroix-Lamandé, Sonia; Vandewalle, Alain; Boneca, Ivo G.; Goujon, Jean-Michel; Werts, Catherine

    2014-01-01

    Background Leptospira (L.) interrogans are bacteria responsible for a worldwide reemerging zoonosis. Rodents carry L. interrogans asymptomatically in their kidneys and excrete bacteria in the urine, contaminating the environment. Humans get infected through skin contact and develop a mild or severe leptospirosis that may lead to renal failure and fibrosis. L. interrogans provoke an interstitial nephritis, but the induction of fibrosis caused by L. interrogans has not been studied in murine models. Innate immune receptors from the TLR and NLR families have recently been shown to play a role in the development and progression of tissue fibrosis in the lung, liver and kidneys under different pathophysiological situations. We recently showed that TLR2, TLR4, and NLRP3 receptors were crucial in the defense against leptospirosis. Moreover, infection of a human cell line with L. interrogans was shown to induce TLR2-dependent production of fibronectin, a component of the extracellular matrix. Therefore, we thought to assess the presence of renal fibrosis in L. interrogans infected mice and to analyze the contribution of some innate immune pathways in this process. Methodology/principal findings Here, we characterized by immunohistochemical studies and quantitative real-time PCR, a model of Leptospira-infected C57BL/6J mice, with chronic carriage of L. interrogans inducing mild renal fibrosis. Using various strains of transgenic mice, we determined that the renal infiltrates of T cells and, unexpectedly, TLR and NLR receptors, are not required to generate Leptospira-induced renal fibrosis. We also show that the iNOS enzyme, known to play a role in Leptospira-induced interstitial nephritis, also plays a role in the induction of renal fibrosis. Conclusion/significance To our knowledge, this work provides the first experimental murine model of sustained renal fibrosis induced by a chronic bacterial infection that may be peculiar, since it does not rely on TLR or NLR receptors

  14. El Efecto del Acoso Psicológico en el Trabajo sobre la Salud: El Papel Mediador del Conflicto Trabajo- Familia

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    Ana Isabel Sanz-Vergel

    2011-01-01

    Full Text Available Los efectos de los estresores psicosociales pueden influir en la vida personal, afectando a la salud. El objetivo de este estudio es analizar el papel mediador del conflicto trabajo-familia en la relación entre el acoso psicológico en el trabajo y problemas de salud. La muestra del estudio estuvo formada por 441 trabajadores de tres empresas del sector de telecomunicaciones ubicadas en la Comunidad de Madrid. Los resultados muestran que el acoso psicológico tiene efectos negativos sobre la salud de forma directa, e indirecta mediante el conflicto trabajo-familia, actuando éste último como mediador parcial. Este hallazgo tiene implicaciones a nivel teórico, puesto que muestra que los efectos negativos de un estresor como es el acoso, se pueden transmitir a través de un conflicto que tiene lugar fuera del ámbito laboral.

  15. Análisis de recursividad estructural con trabajo especializado en la teoría de la inexistencia del mercado de trabajo

    Directory of Open Access Journals (Sweden)

    Juan Roberto Vargas Sánchez

    2015-01-01

    Full Text Available Se desarrolla un an lisis de recursividad estructural tomando como base la teor a de la inexistencia del mercado de trabajo ( . Para lo cual, se incorpora trabajo es - pecializado en el modelo b sico de la , en particular en la organizaci n interna de las empresas, de ah que la producci n sea posible mediante dos especialidades del trabajo indispensables para producir la gesti n y la manufactura. Se demuestra que si el diferencial salarial que resulta de las distintas remuneraciones a las diferentes espe - cialidades no se modifica, el desempleo en el subsector de los trabajadores-gesti n lo genera en el subsector de los trabajadores-manufactura; para restaurar el pleno empleo en el ltimo subsector mencionado, se requiere que el diferencial salarial se incremente. Adem s, se muestra que la existencia de desempleo en el subsector de los trabajadores- manufactura, la ocasiona en el subsector de los trabajadores-gesti n.

  16. Non-invasive ventilation for cystic fibrosis.

    Science.gov (United States)

    Moran, Fidelma; Bradley, Judy M; Piper, Amanda J

    2017-02-20

    Non-invasive ventilation may be a means to temporarily reverse or slow the progression of respiratory failure in cystic fibrosis by providing ventilatory support and avoiding tracheal intubation. Using non-invasive ventilation, in the appropriate situation or individuals, can improve lung mechanics through increasing airflow and gas exchange and decreasing the work of breathing. Non-invasive ventilation thus acts as an external respiratory muscle. This is an update of a previously published review. To compare the effect of non-invasive ventilation versus no non-invasive ventilation in people with cystic fibrosis for airway clearance, during sleep and during exercise. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register comprising references identified from comprehensive electronic database searches, handsearching relevant journals and abstract books of conference proceedings. We searched the reference lists of each trial for additional publications possibly containing other trials.Most recent search: 08 August 2016. Randomised controlled trials comparing a form of pressure preset or volume preset non-invasive ventilation to no non-invasive ventilation used for airway clearance or during sleep or exercise in people with acute or chronic respiratory failure in cystic fibrosis. Three reviewers independently assessed trials for inclusion criteria and methodological quality, and extracted data. Ten trials met the inclusion criteria with a total of 191 participants. Seven trials evaluated single treatment sessions, one evaluated a two-week intervention, one evaluated a six-week intervention and one a three-month intervention. It is only possible to blind trials of airway clearance and overnight ventilatory support to the outcome assessors. In most of the trials we judged there was an unclear risk of bias with regards to blinding due to inadequate descriptions. The six-week trial was the only one judged to have a low risk of bias for all

  17. Non-invasive diagnosis of liver fibrosis and cirrhosis

    Science.gov (United States)

    Lurie, Yoav; Webb, Muriel; Cytter-Kuint, Ruth; Shteingart, Shimon; Lederkremer, Gerardo Z

    2015-01-01

    The evaluation and follow up of liver fibrosis and cirrhosis have been traditionally performed by liver biopsy. However, during the last 20 years, it has become evident that this “gold-standard” is imperfect; even according to its proponents, it is only “the best” among available methods. Attempts at uncovering non-invasive diagnostic tools have yielded multiple scores, formulae, and imaging modalities. All are better tolerated, safer, more acceptable to the patient, and can be repeated essentially as often as required. Most are much less expensive than liver biopsy. Consequently, their use is growing, and in some countries the number of biopsies performed, at least for routine evaluation of hepatitis B and C, has declined sharply. However, the accuracy and diagnostic value of most, if not all, of these methods remains controversial. In this review for the practicing physician, we analyze established and novel biomarkers and physical techniques. We may be witnessing in recent years the beginning of the end of the first phase for the development of non-invasive markers. Early evidence suggests that they might be at least as good as liver biopsy. Novel experimental markers and imaging techniques could produce a dramatic change in diagnosis in the near future. PMID:26556987

  18. Newborn bloodspot screening for cystic fibrosis: What do antenatal and postnatal women know about cystic fibrosis?

    Science.gov (United States)

    Fitzgerald, C; Linnane, B; Heery, E; Conneally, N; George, S; Fitzpatrick, P

    2016-07-01

    The Republic of Ireland has one of the highest reported incidences of cystic fibrosis (CF) in the world (1/1353) with an estimated carrier rate of 1/20. No cure exists, however there have been significant advances in available treatments. Newborn bloodspot screening (NBS) for CF was added to the NBS programme in Ireland in July 2011. Little is known about antenatal or postnatal women's knowledge about CF. This was a cross-sectional study of 662 antenatal (≥36weeks gestation) and 480 postnatal women (post NBS). Women were asked to self-complete a questionnaire including 14 CF knowledge questions. Among the respondents significantly more postnatal than antenatal women were aware that CF is included on the NBS (81.8% vs 63.5%; pdiagnosis. Copyright © 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

  19. Human Genome Project and cystic fibrosis--a symbiotic relationship.

    Science.gov (United States)

    Tolstoi, L G; Smith, C L

    1999-11-01

    When Watson and Crick determined the structure of DNA in 1953, a biological revolution began. One result of this revolution is the Human Genome Project. The primary goal of this international project is to obtain the complete nucleotide sequence of the human genome by the year 2005. Although molecular biologists and geneticists are most enthusiastic about the Human Genome Project, all areas of clinical medicine and fields of biology will be affected. Cystic fibrosis is the most common, inherited, lethal disease of white persons. In 1989, researchers located the cystic fibrosis gene on the long arm of chromosome 7 by a technique known as positional cloning. The most common mutation (a 3-base pair deletion) of the cystic fibrosis gene occurs in 70% of patients with cystic fibrosis. The knowledge gained from genetic research on cystic fibrosis will help researchers develop new therapies (e.g., gene) and improve standard therapies (e.g., pharmacologic) so that a patient's life span is increased and quality of life is improved. The purpose of this review is twofold. First, the article provides an overview of the Human Genome Project and its clinical significance in advancing interdisciplinary care for patients with cystic fibrosis. Second, the article includes a discussion of the genetic basis, pathophysiology, and management of cystic fibrosis.

  20. Diagnosing cystic fibrosis-related diabetes: current methods and challenges.

    Science.gov (United States)

    Prentice, Bernadette; Hameed, Shihab; Verge, Charles F; Ooi, Chee Y; Jaffe, Adam; Widger, John

    2016-07-01

    Cystic fibrosis-related diabetes (CFRD) is the end-point of a spectrum of glucose abnormalities in cystic fibrosis that begins with early insulin deficiency and ultimately results in accelerated nutritional decline and loss of lung function. Current diagnostic and management regimens are unable to entirely reverse this clinical decline. This review summarises the current understanding of the pathophysiology of CFRD, the issues associated with using oral glucose tolerance tests in CF and the challenges faced in making the diagnosis of CFRD. Medline database searches were conducted using search terms "Cystic Fibrosis Related Diabetes", "Cystic Fibrosis" AND "glucose", "Cystic Fibrosis" AND "insulin", "Cystic Fibrosis" AND "Diabetes". Additionally, reference lists were studied. Expert commentary: Increasing evidence points to early glucose abnormalities being clinically relevant in cystic fibrosis and as such novel diagnostic methods such as continuous glucose monitoring or 30 minute sampled oral glucose tolerance test (OGTT) may play a key role in the future in the screening and diagnosis of early glucose abnormalities in CF.

  1. Tumoral fibrosis effect on the radiation absorbed dose of 177Lu-Tyr3-octreotate-gold nanoparticles and 177Lu-Tyr3-octreotate radiopharmaceuticals

    International Nuclear Information System (INIS)

    Zambrano R, O. D.

    2015-01-01

    In this work was comparatively evaluated the effect of tumoral fibrosis in the radiation absorbed dose of the radiopharmaceutical 177 Lu-Tyr 3 -octreotate with and without gold nanoparticles. For this, was used an experimental array of tumoral fibrosis and computer models based on Monte Carlo calculations to simulate tumoral micro environments without fibrosis and with fibrosis. The computer simulation code Penelope (Penetration Energy Loss of Positron and Electrons) and MCNP (Monte Carlo N-particle Transport Code System) which are based on the Monte Carlo methodology were used to create the computer models for the simulation of the transport of particles (emitted by 177 Lu) in the micro environments (without fibrosis and with fibrosis) with the purpose of calculating the radiation absorbed dose in the interstitial space and in the nucleus of cancer cells. The first computational model consisted of multiple concentric spheres (as onion shells) with the radioactive source homogeneously distributed in the shell between 5 and 10 μm in diameter which represents the internalization of the radioactive source into the cell cytoplasm as it occurs in target specific radiotherapy. The concentric spheres were useful to calculate the radiation absorbed dose in depth in the models without fibrosis and with fibrosis. Furthermore, there were constructed other computer models using two different codes that simulate the transport of radiation (Penelope and MCNP). These models consist of seven spheres that represent cancer cells (HeLa cells) of 10 μm in diameter and each one of them contain another smaller sphere in the center that represents the cell nucleus. A comparison was done of the radiation absorbed dose in the nucleus of the cells, calculated with both codes, Penelope and MCNP. The radioactive source ( 177 Lu) used for the simulations was given to the codes by means of a convoluted spectrum of the most important beta particles (high percentage emission). To this spectrum

  2. Regression of liver fibrosis by taurine in rats fed alcohol: effects on collagen accumulation, selected cytokines and stellate cell activation.

    Science.gov (United States)

    Devi, Shanmugam Lakshmi; Viswanathan, Periyaswamy; Anuradha, Carani V

    2010-11-25

    The antifibrogenic effect of taurine in experimental liver fibrosis has been shown. The role of taurine to abate fibrogenic mediators and collagen deposition during liver fibrosis induced by simultaneous administration of iron carbonyl (0.5% w/w) and alcohol (6 g/kg/day) was investigated in this study. Liver histology, the levels of inflammatory cytokines, stellate cell activation, oxidative stress and collagen content were assessed. Liver fibrosis and a rise in collagen content in ethanol plus iron-fed rat were evident from van Gieson and Masson's trichrome staining respectively. Hepatic myeloperoxidase activity and plasma levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were markedly elevated. This was associated with an imbalance in the oxidant-antioxidant system, increased expression of transforming growth factor-β(1) (TGF-β(1)) and stellate cell activation suggested by α-smooth muscle actin (α-SMA) localization. This condition was protected in the presence of taurine. Taurine lowered the levels of IL-6, TNF-α and peroxidation products and the expression of α-SMA, desmin and TGF-β(1) and improved the antioxidant status. A positive relationship between hepatic collagen with iron and lipid peroxides and an inverse relationship between collagen and glutathione were noted. It is concluded that taurine reduces iron-potentiated alcoholic liver fibrosis by curtailing oxidative stress, production of inflammatory and fibrogenic mediators and activation of stellate cells. Copyright © 2010. Published by Elsevier B.V.

  3. Antisense oligonucleotide inhibition of Heat Shock Protein (HSP 47 improves bleomycin-induced pulmonary fibrosis in rats

    Directory of Open Access Journals (Sweden)

    Noguchi Takayuki

    2007-05-01

    Full Text Available Abstract Background The most common pathologic form of pulmonary fibrosis arises from excessive deposition of extracellular matrix proteins such as collagen. The 47 kDa heat shock protein 47 (HSP47 is a collagen-specific molecular chaperone that has been shown to play a major role during the processing and/or secretion of procollagen. Objectives To determine whether inhibition of HSP47 could have beneficial effects in mitigating bleomycin-induced pulmonary fibrosis in rats. Methods All experiments were performed with 250–300 g male Wistar rats. Animals were randomly divided into five experimental groups that were administered: 1 saline alone, 2 bleomycin alone, 3 antisense HSP47 oligonucleotides alone, 4 bleomycin + antisense HSP47 oligonucleotides, and 5 bleomycin + sense control oligonucleotides. We investigated lung histopathology and performed immunoblot and immunohistochemistry analyses. Results In rats treated with HSP47 antisense oligonucleotides, pulmonary fibrosis was significantly reduced. In addition, treatment with HSP47 antisense oligonucleotides significantly improved bleomycin-induced morphological changes. Treatment with HSP47 antisense oligonucleotides alone did not produce any significant changes to lung morphology. Immunoblot analyses of lung homogenates confirmed the inhibition of HSP47 protein by antisense oligonucleotides. The bleo + sense group, however, did not exhibit any improvement in lung pathology compared to bleomycin alone groups, and also had no effect on HSP47 expression. Conclusion These findings suggest that HSP47 antisense oligonucleotide inhibition of HSP47 improves bleomycin-induced pulmonary fibrosis pathology in rats.

  4. Propuesta de aplicación de trabajo en equipo y liderazgo al trabajo comunitario: "Sistema Autónomo Proyecto Nero" Cuenca-Ecuador

    OpenAIRE

    Loja Nieves, Nelly Salome

    2006-01-01

    El Sistema Autónomo Comunitario de Agua Potable Nero, está catalogado como uno de los "principales Sistemas comunitarios del Ecuador y América Latina que se ha desarrollado sin fines de lucro basándose en la solidaridad y autogestión del trabajo reviviendo las costumbres ancestrales de la minga en el austro ecuatoriano". El trabajo comunitario (minga) es un proceso basado en la solidaridad que congrega a jóvenes, mujeres, niños y adultos alrededor de un fin común. Los mingueros buscan desa...

  5. Demandas y características del trabajo como predictores de la salud mental en el trabajo en función del sexo

    OpenAIRE

    EVA CIFRE GALLEGO; SONIA AGUT NIETO; MARISA SALANOVA SORIA

    2000-01-01

    El objetivo del presente trabajo es el estudio de la relación de diferentes características sociodemográficas (nivel educativo, estado civil, maternidad), laborales (características del puesto) y de innovación tecnológica (tiempo de uso de la tecnología en caso de emplear dicha tecnología en su puesto de trabajo) sobre la salud mental de una muestra de mujeres trabajadoras, así como su comparación con una muestra de hombres. Además, se analiza el poder predictivo de ciertas características de...

  6. Effects of leflunomide on inflamation and fibrosis in bleomycine induced pulmonary fibrosis in wistar albino rats.

    Science.gov (United States)

    Kayhan, Servet; Guzel, Aygul; Duran, Latif; Tutuncu, Serife; Guzel, Ahmet; Gunaydın, Mithat; Salis, Osman; Okuyucu, Ali; Selcuk, Mustafa Yasin

    2013-10-01

    Pulmonary fibrosis is a rare and progressive lung disease with a high mortality rate. The treatment regimens still fail to recover the disease. Leflunomide (LEF) is an immunomodulatory agent with antiproliferative activity that is used for the treatment of rheumatoid arthritis. The purpose of the study is to investigate the potential therapeutic efficacy of LEF in bleomycin (BLM) induced pulmonary fibrosis. A total of 21 male, adult wistar albino rats were used. The animals were divided into three groups as control, BLM and BLM plus LEF groups (n=7). In BLM group, mice were treated with intratracheal instillation of BLM (2.5 U/kg). Control group received the same volume of saline instead of BLM. In LEF group, in addition to BLM, LEF (10 mg/kg, daily) was administrated by oral gavage. The effect of LEF on pulmonary inflammation and fibrosis was studied by measurements of serum clara cell protein-16 (CC-16), thiobarbituric acid reactive substance levels (TBARS), superoxide dismutase (SOD) and advanced oxidation protein products (AOPP) levels and lung tissue contents of IL-6, TNF-α and NF-κB by immunhistochemical examinations. LEF significantly increased the level of CC-16 and decreased the level of AOPP (P=0.042 and P=0.003 respectively). Lung tissue contents of IL-6, TNF-α and NF-κB significantly decreased in LEF group compared to BLM group by immunhistochemical examinations (P<0.001). LEF reduces oxidative stress factors, alveolar inflammation and attenuates lung injury and fibrosis.

  7. Accuracy of FibroScan for diagnosing liver fibrosis

    Directory of Open Access Journals (Sweden)

    Jian ZHANG

    2011-11-01

    Full Text Available Objective To evaluate the accuracy of transient elastometry(FibroScan for the detection of liver fibrosis.Methods A total of 323 patients diagnosed with chronic liver disease based on pathological examination in the 302 Hospital of the People’s Liberation Army from April to December of 2009 were involved in the current study.Among them,141 patients were subjected to liver biopsy.Their liver function,coagulant index,B-ultrasound and blood cell count were examined clinically.Four examinations related to liver fibrosis were done on some of the patients.Meanwhile,FibroScan was used for liver stiffness measurement(LSM of every patient.The correlation between liver stiffness and the serologic index and liver fibrosis degree was analyzed.The Receive Operating Characteristic(ROC curve was adopted to analyze the accuracy of FibroScan for diagnosing liver fibrosis.Results Each serologic index was significantly correlated with liver stiffness(P < 0.001,and liver stiffness was closely related to the stage of liver fibrosis(r=0.74,P < 0.001.The statistical results of the 141 patients who underwent pathologic examination show that the areas under the ROC curve were 0.97(0.94,1.00 for patients with portal fibrosis(F1,0.96(0.93,0.99 for patients with significant fibrosis(F2,0.99(0.98,1.00 for patients with severe fibrosis(F3,and 0.97(0.94,0.99 for patients with cirrhosis(F4.The cutoff values were 4.4KPa,6.8KPa,9.7KPa,and 10.0KPa,respectively.Conclusion FibroScan is valuable for the diagnosis of liver fibrosis.It can be used as the basis for follow-up and management of patients with chronic liver diseases.

  8. Singing for children and adults with cystic fibrosis.

    Science.gov (United States)

    Irons, Jung Yoon; Kenny, Dianna Theadora; Chang, Anne B

    2010-05-12

    Cystic fibrosis is a genetically inherited, life-threatening condition that affects major organs. The management of cystic fibrosis involves a multi-faceted daily treatment regimen that includes airway clearance physiotherapy, taking pancreatic enzymes and other medications. Previous studies identified that compliance with this intensive treatment especially among adolescents with cystic fibrosis is poor. Because of both the nature and consequences of the illness and the relentless demands of treatments, many individuals with cystic fibrosis are likely to have a poor quality of life. Anecdotal evidence suggests that singing may provide rigorous exercises for the whole respiratory system as well as a means for emotional expression, which may enhance quality of life. To evaluate the effects of a singing intervention in addition to usual therapy on the quality of life, morbidity, respiratory muscle strength and pulmonary function of children and adults with cystic fibrosis. We searched the Group's Cystic Fibrosis Trials Register, the Cochrane Central Register of Controlled Trials, major allied complementary data bases, and clinical trial registers. Hand searching for relevant conference proceedings and journals was also carried out.Date of search of Trials Register: 02 September 2009.Date of additional searches: 17 September 2009. Randomised controlled trials in which singing (as an adjunctive intervention) is compared with either a sham intervention or no singing in people with cystic fibrosis. No trials were found that met the selection criteria. No meta-analysis could be performed. As no studies that met the criteria were found, this review is unable to support or refute the benefits of singing as a therapy for people with cystic fibrosis. Future randomised controlled trials are required to evaluate singing therapy for people with cystic fibrosis.

  9. Blood Gene Expression Profiling of Breast Cancer Survivors Experiencing Fibrosis

    International Nuclear Information System (INIS)

    Landmark-Hoyvik, Hege; Dumeaux, Vanessa; Reinertsen, Kristin V.; Edvardsen, Hege; Fossa, Sophie D.; Borresen-Dale, Anne-Lise

    2011-01-01

    Purpose: To extend knowledge on the mechanisms and pathways involved in maintenance of radiation-induced fibrosis (RIF) by performing gene expression profiling of whole blood from breast cancer (BC) survivors with and without fibrosis 3-7 years after end of radiotherapy treatment. Methods and Materials: Gene expression profiles from blood were obtained for 254 BC survivors derived from a cohort of survivors, treated with adjuvant radiotherapy for breast cancer 3-7 years earlier. Analyses of transcriptional differences in blood gene expression between BC survivors with fibrosis (n = 31) and BC survivors without fibrosis (n = 223) were performed using R version 2.8.0 and tools from the Bioconductor project. Gene sets extracted through a literature search on fibrosis and breast cancer were subsequently used in gene set enrichment analysis. Results: Substantial differences in blood gene expression between BC survivors with and without fibrosis were observed, and 87 differentially expressed genes were identified through linear analysis. Transforming growth factor-β1 signaling was identified as the most significant gene set, showing a down-regulation of most of the core genes, together with up-regulation of a transcriptional activator of the inhibitor of fibrinolysis, Plasminogen activator inhibitor 1 in the BC survivors with fibrosis. Conclusion: Transforming growth factor-β1 signaling was found down-regulated during the maintenance phase of fibrosis as opposed to the up-regulation reported during the early, initiating phase of fibrosis. Hence, once the fibrotic tissue has developed, the maintenance phase might rather involve a deregulation of fibrinolysis and altered degradation of extracellular matrix components.

  10. Algoritmo para el cálculo de cargas de trabajo

    OpenAIRE

    Mauricio Becerra Fernández; Stefany Ayala Lozano; Jenny Alexandra Astros Hernández; Elsa Cristina González La Rotta

    2016-01-01

    Este artículo presenta el desarrollo un algoritmo para el cálculo de cargas de trabajo, soportado en el análisis de estudios similares y la teoría del estudio de métodos y tiempos. El algoritmo se propone como un elemento de soporte para el análisis del nivel trabajo asignado a un cargo específico o a un grupo de trabajadores en un área determinada, ya sea en la industria de manufactura o de servicios, lo que permita nivelar el volumen de trabajo asignado mediante la definición de diversas al...

  11. Capitalismo cognitivo, trabajo informacional y un poco de música

    Directory of Open Access Journals (Sweden)

    Mariano Zukerfeld

    2008-01-01

    Full Text Available Este artículo está organizado en torno a tres secciones. En la primera, se presenta un resumen de nuestro marco teórico para pensar el capitalismo cognitivo, centrado en el concepto de bienes informacionales. En la segunda, utilizando los datos de un estudio de campo, se aplican las categorías esbozadas para caracterizar algunos aspectos del trabajo de los músicos en la actualidad. Finalmente, se extienden las ideas surgidas de la sección anterior y se propone la noción de trabajo informacional para pensar la forma de trabajo que distingue a la presente etapa.

  12. Trabajo y empleo de las mujeres en contexto de globalización

    OpenAIRE

    2004-01-01

    La presente publicación, que con mucho agrado les estamos entregando a Uds. llamada "Trabajo y empleo de las mujeres colombianas en contexto de globalización", es un esfuerzo de presentar las miradas y apuestas desde la investigación y sistematización colectiva, hasta la presentación de debates y propuestas de abordaje de las políticas laborales en Colombia de diversas autoras de la Mesa de Trabajo Mujeres y Economía. Este trabajo fue y esta apoyado por OXFAM G.B. y se recoge para la Campaña ...

  13. Procedimiento de formación de grupos de trabajo en el proceso software

    OpenAIRE

    Digión, Leda

    2005-01-01

    Para conseguir calidad en el trabajo de un equipo de proyecto informático, no es suficiente con determinar el rol funcional del individuo (analista, programador, etc.) es decir, formar el equipo en función de las tareas a desempeñar. También es necesario identificar el estilo de trabajo de cada integrante, y según este estilo definir grupos de trabajo a cargo de cada subproceso de gestión, dentro del equipo de proyecto informático. A partir de una diferenciación entre los conceptos de grup...

  14. Desarrollo metodológico para medir el trabajo en equipo

    OpenAIRE

    Elisabeth Viles; Carmen Jaca; Martín Tanco; Allan Medina

    2011-01-01

    En el sector sanitario, el trabajo en equipo es una parte importante de su actividad. Aunque el sector fomenta la investigación orientada a mejorar la calidad del trabajo en equipo, pocas veces se focaliza a la evaluación de este proceso. Por esta razón en el presente artículo se desarrolla una propuesta metodológica para evaluar la efectividad del trabajo en equipo. Para ello el modelo contempla 36 factores que son utilizados para su medición, a través de la observación de la existencia, imp...

  15. La espiritualidad en los cuidados paliativos y el papel fundamental del Trabajo Social

    OpenAIRE

    Bernardo Alonso, Paula

    2017-01-01

    El siguiente trabajo intenta destacar la importancia de la atención de necesidades espirituales, en concreto, en los cuidados paliativos y el papel del trabajo social en estas intervenciones. Se realizará una investigación con la participación, a través de cuestionarios, de trabajadores sociales y profesionales de medicina. En ellos se recogerá información sobre la espiritualidad, las necesidades espirituales y la atención de las mismas desde los distintos puestos de trabajo...

  16. CONTRIBUCIONES DE LOS TRABAJOS PRÁCTICOS EN LA CONSTRUCCIÓN DEL CONCEPTO SISTEMA NERVIOSO

    OpenAIRE

    Miguel Angel Martinez Parra; Maria Natalia Rangel Silva; Wilson Cepeda Benavides

    2015-01-01

    Sin duda, el trabajo práctico y, en particular, la actividad de laboratorio constituyen un hecho diferencial propio de la enseñanza de las ciencias. En el presente trabajo, se tomó como punto focal la implementación de trabajos prácticos con el fin de apoyar la construcción del concepto sistema nervioso a partir de dos sesiones de clase y una práctica de laboratorio. Se tuvo en cuenta como punto de partida las ideas previas que presentaban los estudiantes en cuanto a las estructuras del siste...

  17. PARTOGRAMA EN MUJERES MULTÍPARAS CON MANEJO MÉDICO DEL TRABAJO DE PARTO

    OpenAIRE

    Parra C,Mauro; Astudillo D,Julio; Caballero T,Rafael; Terra A,Rodrigo; Araneda A,Max; Atria A,Arturo; Rau M,Carlos; Pérez B,Sebastián

    2007-01-01

    Antecedentes. La evaluación gráfica del parto fue descrito originalmente por Friedman, sin embargo, una descripción de la evolución del trabajo de parto con un manejo médico contemporáneo no ha sido completamente evaluado. Objetivo: Analizar el efecto de un manejo médico estandarizado del trabajo de parto, que incluye anestesia regional, rotura artificial de membranas y conducción ocitócica, sobre la fase activa del trabajo de parto en multíparas. Método. Análisis retrospectivo de 130 multípa...

  18. Elementos cognitivos para el análisis ergonómico del trabajo

    OpenAIRE

    Castillo-Martínez, Juan A; Universidad del Rosario, Escuela de Medicina y Ciencias de la Salud. Grupo de Investigación Salud Cognición y Trabajo

    2007-01-01

    Esta nota de investigación presenta algunos de los elementos de base para el análisis de la actividad del trabajo desde la perspectiva de la ergonomía cognitiva. Para poder aproximarse a la relación existente entre los procesos cognitivos en el trabajo y la noción de ergonomía es necesario abordar inicialmente la definición de esta disciplina. El termino ergonomía, acuñado en 1940 por el psicólogo británico Hywel Murrell, (del Griego ergo: trabajo + nomos: ley, conocimiento)...

  19. Espacialidad y trabajo: los cartoneros en la ciudad de La Plata

    OpenAIRE

    María Eugenia Rausky

    2016-01-01

    En el trabajo que aquí presentamos se aborda la forma que asume el vínculo espacio-trabajo para quienes viven de la recolección de basura, cartón, papel y afines, es decir, los cartoneros –niños y adultos-. Nos preguntamos por el modo en que una actividad que se desarrolla en el espacio público, es vivida por los sujetos que la practican: ¿Qué particularidades asume el trabajo que se lleva a cabo en las calles? ¿Cómo es vivida, sentida y practicada la ciudad por los trabajadores que despliega...

  20. Aporte de las hacenderas y otros trabajos comunitarios a la sostenibilidad social en el medio rural

    OpenAIRE

    Arranz López, Sergio

    2017-01-01

    El trabajo analiza el impacto de las hacendonas y otros trabajos comunitarios en la sostenibilidad social del medio rural. A través de diálogos con vecinos y vecinas de “El Carracillo”, se analiza el impacto de las hacenderas en el desarrollo del capital social, la identidad, el proceso de apropiación del espacio y la relación de estos factores con la sostenibilidad social. El enfoque metodológico del trabajo se basa en una metodología cualitativa con orientación comunicativa crítica. Mást...