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Sample records for fibrosis ten-year prospective

  1. Ten years' of experience in patient education of families with a child/adolescent suffering from cystic fibrosis

    DEFF Research Database (Denmark)

    Bregnballe, Vibeke

    2007-01-01

    Aims: The patient education programme for families with children or adolescents with cystic fibrosis (the CF school) was established ten years ago to enable patients to make choices in their lives as CF patients. The CF school provides patients with knowledge about cystic fibrosis (CF), teaches...

  2. A prospective ten-year follow-up of patients with chronic urticaria.

    Science.gov (United States)

    Dionigi, P C L; Menezes, M C S; Forte, W C N

    2016-01-01

    Chronic urticaria can be the initial clinical presentation of a number of different diseases. The objective of the present study was to report the associated diseases during a ten-year clinical-laboratory follow-up in patients with an initial diagnosis of chronic spontaneous urticaria (CSU) of unknown cause. A prospective, longitudinal cohort study with a ten-year clinical-laboratory follow-up was conducted. Patients with a history of urticarial plaques of over six weeks presenting as the only clinical symptom were selected. Individuals with other clinical conditions, urticaria of known causes or chronic physical urticaria were excluded. The following tests were initially performed: haemogram, urine type I, stool parasite exam and sedimentation rate. The following exams were ordered during follow-up: PPD; urine culture; serology tests; antithyroid and antinuclear antibodies, rheumatoid factor, lupus anticoagulant; thyroid hormones; serum immunoglobulin; paranasal sinus and thorax radiographs; testing for BK and Helicobacter pylori; and prick tests. Infections were diagnosed in 29% of patients (syphilis, parasitosis, H. pylori, urinary infection, tuberculosis, hepatitis B and C); autoimmune diseases in 21% (thyroiditis, rheumatoid arthritis and antiphospholipid antibody syndrome); primary immunodeficiencies in 4% (IgA and IgG2 deficiencies); and chronic myeloid leukaemia in 1%. At ten-years of follow-up, the urticaria diagnosis was CSU of unknown cause in 45% of the cases. This ten-year clinical-laboratory follow-up of 100 individuals with chronic urticaria as the initial diagnosis revealed the presence of associated diseases in over half of the cases. The most prevalent diseases were infections and autoimmune diseases besides primary immunodeficiencies and blood diseases. Copyright © 2016 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.

  3. Graft Fibrosis After Pediatric Liver Transplantation : Ten Years of Follow-up

    NARCIS (Netherlands)

    Scheenstra, Rene; Peeters, Paul M. G. J.; Verkade, Henkjan J.; Gouw, Annette S. H.

    2009-01-01

    Previously we reported the presence of portal fibrosis in 31% (n = 84) of the grafts in protocol biopsies I year after pediatric liver transplantation (LTx). To assess the natural history of graft fibrosis after pediatric liver transplantation, we extended the analysis of graft histology in follow-u

  4. Flouride. Ten-year prospective study of deciduous and permanent dentition.

    Science.gov (United States)

    Margolis, F J; Reames, H R; Freshman, E; MaCauley, C D; Mehaffey, H

    1975-07-01

    A ten-year longitudinal prospective study compared the effect of fluoride on dentition of 1,500 children from infancy through age 10 years. In Kalamazoo, Mich, and Oneida, NY, parallel groups were given a fluoride-vitamin supplement from infancy and from age 4 and compared with fluoridated water and control groups. Incidence of new caries activity in both deciduous and permanent teeth was measured by mean number of new decayed and filled teeth, as well as percentage of children with no caries throughout the periods studied. Prevalence of caries was also studied in six-year molars. The results indicate a consistent (and, for selected groups, a statistically significant) diminution in caries activity for both deciduous and permanent teeth for groups ranked from greatest retardation of caries to least: infant fluoride group, water fluoride group, age 4 fluoride group, and controls.

  5. Ten-Year Survival in Patients with Idiopathic Pulmonary Fibrosis After Lung Transplantation

    NARCIS (Netherlands)

    ten Klooster, Liesbeth; Nossent, George D.; Kwakkel-van Erp, Johanna M.; van Kessel, Diana A.; Oudijk, Erik J.; van de Graaf, Ed A.; Luijk, Bart; Hoek, Rogier A.; van den Blink, Bernt; van Hal, Peter Th.; Verschuuren, Erik A.; van der Bij, Wim; van Moorsel, Coline H; Grutters, Jan C

    2015-01-01

    Introduction Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrosing lung disease with a median survival of approximately 3 years after diagnosis. The only medical option to improve survival in IPF is lung transplantation (LTX). The purpose of this study was to evaluate trajectory

  6. Clinical complications in patients with severe cervical spinal trauma: a ten-year prospective study

    Directory of Open Access Journals (Sweden)

    Egmond Alves Silva Santos

    2012-07-01

    Full Text Available OBJECTIVE: To determine the complications due to severe acrescentar sigla após o nome (CST. METHODS: Between 1997 and 2006, 217 patients (191 men and 26 women were prospectively evaluated. The mean age was 36.75±1.06 years. RESULTS: Forty-five percent of the patients had medical complications. The most important risk factor was alcoholic beverage use. The most important associated injury was head trauma (HT. Patients with American Spine Injury Association (ASIA A or B had a 2.3-fold greater relative risk of developing complications. Thirty-three patients (15.2% died. Patients with neurological deficit had a 16.9-fold higher risk of death. There was no influence of age and time between trauma and surgery on the presence of complications. CONCLUSIONS: Of the patients, 45% had clinical complications and 7.5% had associated injuries; pneumonia was the most important complication; patient age and time between trauma and surgery did not influence the development of medical complications; neurological status was the most important factor in determining morbidity and mortality.

  7. Hallucinations and sleep disorders in PD: ten-year prospective longitudinal study.

    Science.gov (United States)

    Goetz, Christopher G; Ouyang, Bichun; Negron, Alice; Stebbins, Glenn T

    2010-11-16

    To assess prospectively progression and relationship of hallucinations and sleep disorders over a 10-year longitudinal study of patients with Parkinson disease (PD). Eighty-nine patients with PD were recruited to fill cells of normal sleep without hallucinations (n = 20), sleep fragmentation only (n = 20), vivid dreams/nightmares (n = 20), hallucinations with insight (n = 20), and hallucinations without insight (n = 9). At baseline, 0.5, 1.5, 4, 6, and 10 years, sleep disorders and hallucinations were assessed by standardized scales with the longitudinal data analyzed by generalized estimating equations with assumptions of linearity in time. At 10 years, we could account for all subjects (27 interviewed, 61 deceased, and 1 too ill for interview). Hallucination prevalence and severity increased over time (p < 0.0001, p = 0.0001). Acting out dreams also increased over time (p = 0.001). In contrast, presence of vivid dreams/nightmares or sleep fragmentation did not increase over time. For all visits, the prevalence of sleep fragmentation did not differ between subjects with vs without hallucinations (odds ratio [OR] = 1.50, p = 0.09). However, severe sleep fragmentation was associated with concurrent hallucinations (OR 2.01, p = 0.006). The presence of hallucinations was also highly associated with concurrent vivid dreams/nightmares (OR = 2.60, p < 0.0001) and with concurrent acting out dreams (OR = 2.38, p = 0.0004). Among the baseline nonhallucinators, no sleep abnormalities at study entry predicted future development of hallucinations. Hallucinations and sleep abnormalities follow very different patterns of progression in PD over 10 years. Whereas patients with hallucinations often have concurrent sleep aberrations, no sleep problem is predictive of future hallucinations.

  8. Dez anos de cirurgia da endomiocardiofibrose: o que aprendemos? Ten years of surgery for endomyocardial fibrosis: what have we learned?

    Directory of Open Access Journals (Sweden)

    Carlos R Moraes

    1987-04-01

    Full Text Available Nos últimos 10 anos (1977-1987, 53 pacientes com endomiocardiofibrose foram submetidos a decortição endocárdica e substituição das valvas atrioventriculares. Quarenta e dois eram do sexo feminino e 11, do masculino, variando a idade de 11 a 59 anos (média 31. Os pacientes foram divididos em três grupos: Grupo I, incluindo 25 doentes com lesão biventricular; Grupo II, composto de 23 pacientes com lesão isolada do ventrículo direito, e, por fim, Grupo III, formado de 5 enfermos com doença apenas no ventrículo esquerdo. Todos estavam na classe funcional III ou IV, de acordo com a classificação da New York Heart Association. A mortalidade, nos primeiros 30 dias após a cirurgia, foi de 20,7% (11 casos. Dos 42 sobreviventes, 21 (39,6% tiveram um pós-operatório imediato bastante tormentoso. Houve 10(18,8% óbitos tardios. Uma paciente foi reoperada dois anos depois, para substituição da valva mitral, que havia sido preservada na primeira intervenção. Dentre os 32 sobreviventes (tempo de evolução de 4,1 pacientes/ano, somente 22 (41,5% estão na classe funcional I ou II. A curva atuarial mostrou que a probabilidade de sobrevida em 5 anos é de 75%. A despeito da elevada mortalidade imediata, ou tardia, e do fato de que menos da metade dos pacientes operados apresentam melhora clínica na evolução a longo prazo, o tratamento cirúrgico é a única esperança de recuperação para pacientes com endomiocardiofibrose. Aspectos técnicos importantes da operação são descritos.In the last 10 years(1977-1987, 53 patients with endomyocardial fibrosis were submitted to endocardial decortication and atrioventricular valve replacement. There were 42 female and 11 male patients, ranging in age from 11 to 59 years (mean 31. The patients were divided into three groups: Group I included 25 patients with bilateral disease; Group II consisted of 23 patients with endomyocardial fibrosis of the right side; and Group III included 5 patients with

  9. IREDA: ten years on

    Energy Technology Data Exchange (ETDEWEB)

    Sahai, I.M.

    1998-04-01

    The Indian Renewable Energy Development Agency has a ten-year history of promoting small hydro energy sources for many communities beyond the reach of the national grid. Sources of funding for hydro installations in India are mentioned. It is suggested that the expansion of the hydro schemes would benefit from greater co-ordination between central and state governments. (UK)

  10. Affordances: Ten Years On

    Science.gov (United States)

    Brown, Jill P.; Stillman, Gloria

    2014-01-01

    Ten years ago the construct, affordance, was rising in prominence in scholarly literature. A proliferation of different uses and meanings was evident. Beginning with its origin in the work of Gibson, we traced its development and use in various scholarly fields. This paper revisits our original question with respect to its utility in mathematics…

  11. Efficacy and safety of outpatient parenteral antibiotic therapy for infective endocarditis: a ten-year prospective study.

    Science.gov (United States)

    Cervera, Carlos; del Río, Ana; García, Laura; Sala, Marta; Almela, Manel; Moreno, Asunción; Falces, Carlos; Mestres, Carlos A; Marco, Francesc; Robau, Marga; Gatell, José M; Miró, José M

    2011-10-01

    The length of treatment of infective endocarditis (IE) with parenteral antibiotics varies from 2 to 6 weeks. Although several studies indicate that outpatient parenteral antibiotic treatment (OPAT) could be safe for uncomplicated viridans-group streptococci (VGS) IE, the experience in Spain is limited and data on other types of endocarditis and OPAT are scarce worldwide. Prospective single center study of a cohort including all patients with IE admitted to the Hospital Clinic of Barcelona OPAT program from January 1997 to December 2006. During the study period, 392 consecutive episodes of IE in non-drug abusers were attended to. Of these, 73 episodes (42 native-valve, 23 prosthetic-valve, and 8 pacemaker-lead) were admitted to the OPAT program (19%). The percentage of inclusion was higher for viridans group streptococci (VGS) or Streptococcus bovis (S. bovis) IE (32% of all VGS or S. bovis IE episodes diagnosed vs. 14% of the remaining etiologies, P<.001). Twelve patients (16%) were readmitted due to complications, of which 3 died (4%). Glycopeptides use was the only predictor factor of hospital readmission (OR 4.5, 95% confidence interval 1.2; 16.8, P=.026). No differences in OPAT outcome were found between VGS plus S. bovis IE and Staphylococcus aureus (S. aureus) plus coagulase-negative staphylococci IE. Patients spent a median of 17 day on OPAT (interquartile range 11-26.5), which enabled 1,466 days of hospital stay to be saved. These data suggest that OPAT for IE may be a safe and effective therapeutic approach in the treatment of selected patients with types of endocarditis other than uncomplicated VGS or S. bovis endocarditis, although patients taking glycopeptides need close clinical OPAT monitoring. Copyright © 2011 Elsevier España, S.L. All rights reserved.

  12. Estimates of outcomes up to ten years after stroke: analysis from the prospective South London Stroke Register.

    Directory of Open Access Journals (Sweden)

    Charles D A Wolfe

    2011-05-01

    Full Text Available Although stroke is acknowledged as a long-term condition, population estimates of outcomes longer term are lacking. Such estimates would be useful for planning health services and developing research that might ultimately improve outcomes. This burden of disease study provides population-based estimates of outcomes with a focus on disability, cognition, and psychological outcomes up to 10 y after initial stroke event in a multi-ethnic European population.Data were collected from the population-based South London Stroke Register, a prospective population-based register documenting all first in a lifetime strokes since 1 January 1995 in a multi-ethnic inner city population. The outcomes assessed are reported as estimates of need and included disability (Barthel Index 10, and mental and physical domain scores of the Medical Outcomes Study 12-item short form (SF-12 health survey. Estimates were stratified by age, gender, and ethnicity, and age-adjusted using the standard European population. Plots of outcome estimates over time were constructed to examine temporal trends and sociodemographic differences. Between 1995 and 2006, 3,373 first-ever strokes were registered: 20%-30% of survivors had a poor outcome over 10 y of follow-up. The highest rate of disability was observed 7 d after stroke and remained at around 110 per 1,000 stroke survivors from 3 mo to 10 y. Rates of inactivity and cognitive impairment both declined up to 1 y (280/1,000 and 180/1,000 survivors, respectively; thereafter rates of inactivity remained stable till year eight, then increased, whereas rates of cognitive impairment fluctuated till year eight, then increased. Anxiety and depression showed some fluctuation over time, with a rate of 350 and 310 per 1,000 stroke survivors, respectively. SF-12 scores showed little variation from 3 mo to 10 y after stroke. Inactivity was higher in males at all time points, and in white compared to black stroke survivors, although black

  13. Ten years of PAMELA

    Science.gov (United States)

    Spillantini, Piero

    2016-07-01

    Pamela experiment has been designed as a cosmic ray observatory at 1 AU, dedicated to the precise and high statistics study of CR fluxes on a three decades energy range, form a few tens MeV up to several hundred GeV region. It is the last step of the 'Russian-Italian Mission' (RIM) program born in 1992 between several Italian and Russian institutes and with the participation of the Royal Institute of Technology of Stockholm (Sweden) and the Siegen University (German). Launched the 16 June 2006 from Baikonur cosmodrome on board of the Resurs-DK1 Russian satellite by a Soyuz rocket in an elliptical (350-610 km) quasi polar orbit (70° inclination) it was activated on 21 June 2006, afterword has been in a continuous data taking mode for ten years. The Pamela program pays particular attention to the study of particles (protons and electrons) and antiparticles (antiprotons and positrons) energy spectra. It also includes search for possible signals of dark matter annihilation, search for primordial antimatter (antihelium), search for new Matter in the Universe (Strangelets?), study of cosmic-ray propagation, solar physics and solar modulation, terrestrial magnetosphere. This program is made possible thanks to the outstanding performance of the instrument, the low energy threshold, the quasi-polar orbit, the 10 years duration of the observation. Protons and helium nuclei are the most abundant components of the cosmic radiation and the precise measurements of their fluxes allow understanding the acceleration and propagation of cosmic rays in the Galaxy. Their spectral shapes cannot be well described by a single power law: at 230-240 GV they exhibit an abrupt spectral hardening. They challenge the current paradigm of cosmic-ray acceleration in supernova remnants followed by diffusive propagation in the Galaxy. Of paramount importance is the discover of the anomalous increase of the positron flux at energies higher that 50 GeV (the so called 'Pamela anomaly'). The review of

  14. A prospective comparative study of cementless total hip arthroplasty and hip resurfacing in patients under the age of 55 years: a ten-year follow-up.

    Science.gov (United States)

    Haddad, F S; Konan, S; Tahmassebi, J

    2015-05-01

    The aim of this study was to evaluate the ten-year clinical and functional outcome of hip resurfacing and to compare it with that of cementless hip arthroplasty in patients under the age of 55 years. Between 1999 and 2002, 80 patients were enrolled into the study: 24 were randomised (11 to hip resurfacing, 13 to total hip arthroplasty), 18 refused hip resurfacing and chose cementless total hip arthroplasty with a 32 mm bearing, and 38 insisted on resurfacing. The mean follow-up for all patients was 12.1 years (10 to 14). Patients were assessed clinically and radiologically at one year, five years and ten years. Outcome measures included EuroQol EQ5D, Oxford, Harris hip, University of California Los Angeles and University College Hospital functional scores. No differences were seen between the two groups in the Oxford or Harris hip scores or in the quality of life scores. Despite a similar aspiration to activity pre-operatively, a higher proportion of patients with a hip resurfacing were running and involved in sport and heavy manual labour after ten years. We found significantly higher function scores in patients who had undergone hip resurfacing than in those with a cementless hip arthroplasty at ten years. This suggests a functional advantage for hip resurfacing. There were no other attendant problems.

  15. A Ten-Year Reflection

    Science.gov (United States)

    Phillip, Cyndi

    2016-01-01

    Five initiatives launched during Cyndi Phillip's term as American Association of School Librarians (AASL) President (2006-2007) continue to have an impact on school librarians ten years later. They include the rewriting of AASL's learning standards, introduction of the SKILLS Act, the presentation of the Crystal Apple Award to Scholastic Library…

  16. Clinical prospective evaluation of zirconia-based three-unit posterior fixed dental prostheses: Up-to ten-year results.

    Science.gov (United States)

    Ioannidis, Alexis; Bindl, Andreas

    2016-04-01

    Only a few studies exist, which assess the clinical long-term behavior of all-ceramic FDPs in the posterior region. The aim of the present prospective clinical study was to evaluate the clinical performance of posterior three-unit FDPs manufactured from Y-TZP after a service period up to 10 years. 55 patients received 59 three-unit FDPs in the posterior region of the maxilla or mandible. Abutment teeth were prepared and full-arch impressions were taken. Definitive casts were fabricated and optically scanned. Frameworks were fabricated with computer-aided design (CAD) and manufacturing (CAM) technology. Y-TZP frameworks were veneered and adhesively luted to the abutment teeth. Baseline and follow-up examinations (service time: ≥ 48 months) were recorded by applying modified United States Public Health Services (USPHS) rating criteria. Cumulative survival rate was analyzed with Kaplan-Meier. Percentage of biological and technical complication was calculated. Fifty-three patients with 57 FDPs attended the last follow-up visit and a mean observation period of the remaining was 6.3 ± 1.9 years was calculated. Biological complications occurred in 17.5%, technical complications in 28% of the FDPs. The 10-year cumulative survival rate amounted 85.0%. Three FDPs failed to survive, two due to a root fracture of the abutment tooth and one due to secondary caries. Three-unit FDPs made from Y-TZP, veneered with ceramic offer a treatment option with a high rate of chipping. However, the manufacturing processes nowadays are modified in order to avoid this complication. The results of the present investigation suggest that three-unit Y-TZP posterior FDPs may are a possible treatment option. However, a high rate of chipping can be expected. Copyright © 2016. Published by Elsevier Ltd.

  17. Czech, Slovak science ten years after split

    CERN Document Server

    2003-01-01

    Ten years after the split of Czechoslovakia Czech and Slovak science are facing the same difficulties: shortage of money for research, poor salaries, obsolete equipment and brain drain, especially of the young, according to a feature in the Daily Lidove Noviny (1 page).

  18. 'Safe handling of nanotechnology' ten years on

    Science.gov (United States)

    Maynard, Andrew D.; Aitken, Robert J.

    2016-12-01

    In 2006, a group of scientists proposed five grand challenges to support the safe handling of nanotechnology. Ten years on, Andrew Maynard and Robert Aitken -- two of the original authors -- look at where we have come, and where we still need to go.

  19. Ten-year urban forestry action plan

    Science.gov (United States)

    J.W." Jerry" Van Sambeek

    2017-01-01

    The Ten-year Urban Forestry Action Plan: 2016-2026 was published in September, 2015 (see http://www.urbanforestry.subr.edu/FinalActionPlan_Complete_11_17_15.pdf). This 260 page heavily illustrated document was prepared by the National Urban and Community Forestry Advisory Council (NUCFAC) under leadership and funding from the USDA Forest Service. The Plan's...

  20. Ten years of monetary union in retrospect

    OpenAIRE

    2008-01-01

    1 January 1999 saw the start of the third and final phase of European Economic and Monetary Union (EMU). Ten years on, membership has expanded from the initial 11 members to reach 16 countries by January 2009. This article reviews the first decade of monetary union from a number of angles. Monetary policy under EMU managed to secure historically low inflation, thereby creating the conditions for sustainable economic growth. Despite large relative price movements stemming from globalisation, i...

  1. A Review, Reflection and Prospect of the New Curriculum Reform of Primary Chinese in the Past Ten Years%小学语文新课程改革十年回顾、反思与展望

    Institute of Scientific and Technical Information of China (English)

    范锦飘

    2012-01-01

    This paper has reviewed the new curriculum reform of primary Chinese, which can be roughly divided into two phases: the concept-popularized phase and rational return phase. The achievements made in such reform have been strikingly noticeable in the past ten years. Nevertheless, there still exist some problems which deserve our reflections. These problems include those of coordination between educational conception and teaching practice, what to be taught and lack of creativity. The future development of primary Chinese will inevitably be students-oriented, children-oriented and elegance-oriented, and will have to pay more attention to the students' growth.%回顾十年来小学语文新课程改革,大致可以分成两个阶段,第一阶段是全民讲“新课程、新理念”的阶段,第二阶段是理性回归的阶段。十年来,小学语文新课程改革所取得的成绩有目共睹,但是仍然有不少问题与困难值得我们反思,主要是教学理念与教学实践协调融合的问题、语文课教什么的问题和创造力缺失的问题。展望小学语文今后发展的方向,必将往生本语文、儿童语文、书香语文的方向发展,更加注重学生个人生命成长。

  2. Ten Years of ENA Imaging from Cassini

    Science.gov (United States)

    Brandt, Pontus; Mitchell, Donald; Westlake, Joseph; Carbary, James; Paranicas, Christopher; Mauk, Barry; Krimigis, Stamatios

    2014-05-01

    In this presentation we will provide a detailed review of the science highlights of the ENA observations obtained by The Ion Neutral Camera (INCA) on board Cassini. Since the launch of Cassini, INCA has unveiled an invisible world of hot plasma and neutral gas of the two biggest objects of our solar system: the giant magnetosphere of Jupiter and Saturn. Although more than ten years ago, INCA captured the first ENA images of the Jovian system revealing magnetospheric dynamics and an asymmetric Europa neutral gas torus. Approaching Saturn, INCA observed variability of Saturn's magnetospheric activity in response to changes in solar wind dynamic pressure, which was contrary to expectations and current theories. In orbit around Saturn, INCA continued the surprises including the first imaging and global characterization of Titan's exosphere extended out to its gravitational Hill sphere; recurring injections correlating with periodic Saturn Kilometric Radiation (SKR) bursts and magnetic field perturbations; and the discovery of energetic ionospheric outflow. Perhaps most significant, and the focal point of this presentation, is INCA's contribution to the understanding of global magnetospheric particle acceleration and transport, where the combination between ENA imaging and in-situ measurements have demonstrated that transport and acceleration of plasma is likely to occur in a two-step process. First, large-scale injections in the post-midnight sector accelerate and transport plasma in to about 12 RS up to energies of several hundreds of keV. Second, centrifugal interchange acts on the plasma inside of this region and provides further heating and transport in to about 6RS. We discuss this finding in the context of the two fundamental types of injections (or ENA intensifications) that INCA has revealed during its ten years of imaging. The first type is large-scale injections appearing beyond 12 RS in the post-midnight sector that have in many cases had an inward component

  3. Ten years for the public Web

    CERN Multimedia

    2003-01-01

    Ten years ago, CERN issued a statement declaring that a little known piece of software called the World Wide Web was in the public domain. Nowadays, the Web is an indispensable part of modern communications. The idea for the Web goes back to March 1989 when CERN Computer scientist Tim Berners-Lee wrote a proposal for a 'Distributed Information Management System' for the high-energy physics community. The Web was originaly conceived and developed to meet the demand for information sharing between scientists working all over the world. There were many obstacles in the 1980s to the effective exchange of information. There was, for example a great variety of computer and network systems, with hardly any common features. The main purpose of the web was to allow scientists to access information from any source in a consistent and simple way. By Christmas 1990, Berners-Lee's idea had become the World Wide Web, with its first server and browser running at CERN. Through 1991, the Web spread to other particle physics ...

  4. Choledochal cysts: our ten year experience.

    LENUS (Irish Health Repository)

    Cianci, F

    2012-04-01

    We present our experience in the management of choledochal cysts from 1999 to 2009. A retrospective review of all charts with a diagnosis of choledochal cysts in our institution in this ten-year period. Data was collated using Excel. A total of 17 patients were diagnosed with choledochal cyst: 9 females and 8 males. The average age at diagnosis was 28 months (range from 0 to 9 years). The most common presenting symptoms were obstructive jaundice 6 (35%) and abdominal pain and vomiting 4 (23%). Ultrasound (US) was the initial diagnostic test in all cases with 4 patients requiring further investigations. All patients underwent Roux-en-Y Hepaticojejunostomy. The average length of stay was 11 days. Patients were followed up with Liver Function Tests (LFTS) and US 4-6 weeks post-operatively. Three patients developed complications including post-op collection, high drain output requiring blood transfusion and adhesive bowel obstruction. Our overall experience with choledochal cyst patients has been a positive one with effective management and low complication rates.

  5. Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with Juvenile Idiopathic Arthritis: results from the childhood arthritis prospective Study.

    Science.gov (United States)

    McErlane, Flora; Foster, Helen E; Carrasco, Roberto; Baildam, Eileen M; Chieng, S E Alice; Davidson, Joyce E; Ioannou, Yiannis; Wedderburn, Lucy R; Thomson, Wendy; Hyrich, Kimme L

    2016-07-01

    The medical management of JIA has advanced significantly over the past 10 years. It is not known whether these changes have impacted on outcomes. The aim of this analysis was to identify and describe trends in referral times, treatment times and 1-year outcomes over a 10-year period among children with JIA enrolled in the Childhood Arthritis Prospective Study. The Childhood Arthritis Prospective Study is a prospective inception cohort of children with new-onset inflammatory arthritis. Analysis included all children recruited in 2001-11 with at least 1 year of follow-up, divided into four groups by year of diagnosis. Median referral time, baseline disease pattern (oligoarticular, polyarticular or systemic onset) and time to first definitive treatment were compared between groups. Where possible, clinical juvenile arthritis disease activity score (cJADAS) cut-offs were applied at 1 year. One thousand and sixty-six children were included in the analysis. The median time from symptom onset and referral to first paediatric rheumatology appointment (22.7-24.7 and 3.4-4.7 weeks, respectively) did not vary significantly (∼20% seen within 10 weeks of onset and ∼50% within 4 weeks of referral). For oligoarticular and polyarticular disease, 33.8-47 and 25.4-34.9%, respectively, achieved inactive disease by 1 year, with ∼30% in high disease activity at 1 year. A positive trend towards earlier definitive treatment reached significance in oligoarticular and polyarticular pattern disease. Children with new-onset JIA have a persistent delay in access to paediatric rheumatology care, with one-third in high disease activity at 1 year and no significant improvement over the past 10 years. Contributing factors may include service pressures and poor awareness. Further research is necessary to gain a better understanding and improve important clinical outcomes. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Rheumatology.

  6. Randomized Trial of Treatment for Children with Sexual Behavior Problems: Ten-Year Follow-Up

    Science.gov (United States)

    Carpentier, Melissa Y.; Silovsky, Jane F.; Chaffin, Mark

    2006-01-01

    This study prospectively follows 135 children 5-12 years of age with sexual behavior problems from a randomized trial comparing a 12-session group cognitive-behavioral therapy (CBT) with group play therapy and follows 156 general clinic children with nonsexual behavior problems. Ten-year follow-up data on future juvenile and adult arrests and…

  7. Managing mountain hardwoods - a ten-year appraisal

    Science.gov (United States)

    George R., Jr. Trimble

    1961-01-01

    Ten years ago - in 1949 - four 5-acre plots were established on the Fernow Experimental Forest near Parsons, West Virginia, to show the effects upon mountain hardwoods of each of four management treatments.

  8. Effects of ten years treated wastewater drip irrigation on soil ...

    African Journals Online (AJOL)

    Effects of ten years treated wastewater drip irrigation on soil microbiological properties under ... Water shortage in most countries of the southern Mediterranean basin has led to the reuse of municipal wastewater for irrigation. ... Article Metrics.

  9. Ten-year survival of cemented total knee replacement in patients aged less than 55 years.

    Science.gov (United States)

    Keenan, A C M; Wood, A M; Arthur, C A; Jenkins, P J; Brenkel, I J; Walmsley, P J

    2012-07-01

    We report the ten-year survival of a cemented total knee replacement (TKR) in patients aged 55 years at the time of surgery, and compare the functional outcome with that of patients aged > 55 years. The data were collected prospectively and analysed using Kaplan-Meier survival statistics, with revision for any reason, or death, as the endpoint. A total of 203 patients aged 55 years were identified. Four had moved out of the area and were excluded, leaving a total of 221 TKRs in 199 patients for analysis (101 men and 98 women, mean age 50.6 years (28 to 55)); 171 patients had osteoarthritis and 28 had inflammatory arthritis. Four patients required revision and four died. The ten-year survival using revision as the endpoint was 98.2% (95% confidence interval 94.6 to 99.4). Based on the Oxford knee scores at five and ten years, the rate of dissatisfaction was 18% and 21%, respectively. This was no worse in the patients aged 55 years than in patients aged > 55 years. These results demonstrate that the cemented PFC Sigma knee has an excellent survival rate in patients aged 55 ten years post-operatively, with clinical outcomes similar to those of an older group. We conclude that TKR should not be withheld from patients on the basis of age.

  10. Eight to ten years follow-up after carotid endarterectomy

    DEFF Research Database (Denmark)

    Knudsen Rathenborg, Lisbet; Sillesen, H; Schroeder, T

    1990-01-01

    Follow-up information was obtained on 185 patients who consecutively underwent carotid endarterectomy eight to ten years previously. Doppler ultrasound examination was performed in 59 patients who were still alive and living within 100 miles of the hospital. Using lifetable analysis, the annual r...

  11. Ten-year-olds' reflections on their life in preschool

    DEFF Research Database (Denmark)

    Broström, Stig

    2016-01-01

    What do children think of their time in preschool? In the present study, twelve ten-year-old children collected data from their classmates. The children tend to remember their friends, and reflect on what games they played and with whom. Only about one in three respondents even mentioned the day...

  12. Personal experiences of cystic fibrosis (CF) carrier couples prospectively identified in CF families

    NARCIS (Netherlands)

    Henneman, L; Kooij, L; Bouman, K; ten Kate, LP

    2002-01-01

    This qualitative study explores the experiences of cystic fibrosis (CF) carrier couples, prospectively identified in CF families, and the impact of the resulting genetic risk on reproductive behavior. Of the 12 couples identified until 1997, seven couples participated in semistructured interviews an

  13. Lessons learned from ten years of distance learning outreach*

    Science.gov (United States)

    Locatis, Craig; Gaines, Cynthia; Liu, Wei-Li; Gill, Michael; Ackerman, Michael

    2015-01-01

    Objective: The study tested the efficacy of providing distance learning with real-time videoconferencing to broaden high school student knowledge of health careers. Methods: A pilot program was tried out and extended over ten years to include other schools in four different time zones and the National Library of Medicine. Survey results, site visits, and continued school participation were used as effectiveness indicators. Student ratings, site visits, and ongoing discussions were used to evaluate critical factors in the program. Results: Nine program factors contributed to success. Conclusions: Synchronous communication can be effective for outreach to special populations given appropriate infrastructure, technology, program design, and implementation. PMID:25918486

  14. Lessons learned from ten years of distance learning outreach.

    Science.gov (United States)

    Locatis, Craig; Gaines, Cynthia; Liu, Wei-Li; Gill, Michael; Ackerman, Michael

    2015-04-01

    The study tested the efficacy of providing distance learning with real-time videoconferencing to broaden high school student knowledge of health careers. A pilot program was tried out and extended over ten years to include other schools in four different time zones and the National Library of Medicine. Survey results, site visits, and continued school participation were used as effectiveness indicators. Student ratings, site visits, and ongoing discussions were used to evaluate critical factors in the program. Nine program factors contributed to success. Synchronous communication can be effective for outreach to special populations given appropriate infrastructure, technology, program design, and implementation.

  15. The next ten years in neonatology: new directions in research

    Directory of Open Access Journals (Sweden)

    Vassilios Fanos

    2014-06-01

    Full Text Available This paper is a prelude to proceedings of the 10th International Workshop on Neonatology to be held in Cagliari, Italy from October 21st to 25th, 2014. These proceedings will be a significant milestone, highlighting the new frontiers of perinatal and neonatal research. Over the five days of this meeting, we aim to (1 examine the roots of the new directions in perinatal and neonatal research; (2 predict the trajectories of advancement in medical technologies, research, clinical care and teaching that will be the future of perinatology and neonatology. The discussion will be in four sections:back to the future: the placenta and perinatal programming;paradigm shift: the revolution of metabolomics in perinatalogy and neonatology;brave new world: the microbiome and microbiomics from perinatal to adult life;new inhabitants on the planet earth: adults who were born with extremely low birth weight. Proceedings of the 10th International Workshop on Neonatology · Cagliari (Italy · October 22nd-25th, 2014 · The last ten years, the next ten years in Neonatology Guest Editors: Vassilios Fanos, Michele Mussap, Gavino Faa, Apostolos Papageorgiou

  16. Ten Years of Cooperation Between Mobile Robots and Sensor Networks

    Directory of Open Access Journals (Sweden)

    Jesus Capitán Fernández

    2015-06-01

    Full Text Available This paper presents an overview of the work carried out by the Group of Robotics, Vision and Control (GRVC at the University of Seville on the cooperation between mobile robots and sensor networks. The GRVC, led by Professor Anibal Ollero, has been working over the last ten years on techniques where robots and sensor networks exploit synergies and collaborate tightly, developing numerous research projects on the topic. In this paper, based on our research, we introduce what we consider some relevant challenges when combining sensor networks with mobile robots. Then, we describe our developed techniques and main results for these challenges. In particular, the paper focuses on autonomous self-deployment of sensor networks; cooperative localization and tracking; self-localization and mapping; and large-scale scenarios. Extensive experimental results and lessons learnt are also discussed in the paper.

  17. Ten Years of Cooperation Between Mobile Robots and Sensor Networks

    Directory of Open Access Journals (Sweden)

    Jesus Capitán Fernández

    2015-06-01

    Full Text Available This paper presents an overview of the work carried out by the Group of Robotics, Vision and Control (GRVC at the University of Seville on the cooperation between mobile robots and sensor networks. The GRVC, led by Professor Anibal Ollero, has been working over the last ten years on techniques where robots and sensor networks exploit synergies and collaborate tightly, developing numerous research projects on the topic. In this paper, based on our research, we introduce what we consider some relevant challenges when combining sensor networks with mobile robots. Then, we describe our developed techniques and main results for these challenges. In particular, the paper focuses on autonomous self-deployment of sensor networks; cooperative localization and tracking; self-localization and mapping; and large-scale scenarios. Extensive experimental results and lessons learnt are also discussed in the paper.

  18. Ten Years of Support for Basic Scientific Research by CONACYT

    Directory of Open Access Journals (Sweden)

    Luis Humberto Fabila Castillo

    2014-01-01

    Full Text Available This paper reviews the results of ten years of support for basic scientific research by the CONACYT. The paper identifies the strongest areas of knowledge in basic science in Mexico and concludes that the institutions where basic science is done are mainly public higher education institutions, followed by also public research centers, while private institutions of higher education and companies carry out almost no research in basic science. Findings show that research on basic science in state universities has grown impressively in recent years, reaching the level of the institutions of higher education of the Federal District. Finally, the implications of these findings as well as the public policies through which support has been granted are discussed.

  19. Ten-year global distribution of downwelling longwave radiation

    Directory of Open Access Journals (Sweden)

    K. G. Pavlakis

    2003-10-01

    Full Text Available Downwelling longwave fluxes, DLFs, have been derived for each month over a ten year period (1984–1993, on a global scale with a resolution of 2.5° × 2.5°.

    The fluxes were computed using a deterministic model for atmospheric radiation transfer, along with satellite and reanalysis data for the key atmospheric input parameters, i.e. cloud properties, and specific humidity and temperature profiles. The cloud climatologies were taken from the latest released and improved International Satellite Climatology Project D2 series. Specific humidity and temperature vertical profiles were taken from three different reanalysis datasets; NCEP/NCAR, GEOS, and ECMWF (acronyms explained in main text. DLFs were computed for each reanalysis dataset, with differences reaching values as high as 30 Wm−2 in specific regions, particularly over high altitude areas and deserts. However, globally, the agreement is good, with the rms of the difference between the DLFs derived from the different reanalysis datasets ranging from 5 to 7 Wm−2. The results are presented as geographical distributions and as time series of hemispheric and global averages. The DLF time series based on the different reanalysis datasets show similar seasonal and inter-annual variations, and similar anomalies related to the 86/87 El Niño and 89/90 La Niña events. The global ten-year average of the DLF was found to be between 342.2 Wm−2 and 344.3 Wm−2, depending on the dataset. We also conducted a detailed sensitivity analysis of the calculated DLFs to the key input data. Plots are given that can be used to obtain a quick assessment of the sensitivity of the DLF to each of the three key climatic quantities, for specific climatic conditions corresponding to different regions of the globe. Our model downwelling fluxes are validated against available data from ground-based stations distributed over the globe, as given by the Baseline

  20. A ten year Moment Tensor database for Western Greece

    Science.gov (United States)

    Serpetsidaki, Anna; Sokos, Efthimios; Tselentis, G.-Akis

    2016-10-01

    Moment Tensors (MTs) provide important information for seismotectonic, stress distribution and source studies. It is also important as a real time or near real time information in shakemaps, tsunami warning, and stress transfer. Therefore a reliable and rapid MT computation is a routine task for modern seismic networks with broadband sensors and real-time digital telemetry. In this paper we present the database of Moment Tensor solutions computed during the last ten years in Western Greece by the University of Patras, Seismological Laboratory (UPSL). The data from UPSL broad band network were used together with the ISOLA Moment Tensor inversion package for routine MT calculation. The procedures followed and the comparison of UPSL derived solutions with the ones provided by other agencies for Western Greece region are presented as well. The Moment Tensor database includes solutions for events in the magnitude range 2.8-6.8 and provides a unique insight into the faulting characteristics of Western Greece. Moreover it paves the way for detailed studies of stress tensor and stress transfer. The weak events' Moment Tensor included in UPSL's database are important for the comprehension of local seismotectonics and reveal the role of minor faults, which may be critical in seismic hazard estimation.

  1. Ten years of integrated care for the older in France

    Directory of Open Access Journals (Sweden)

    Dominique Somme

    2011-12-01

    Full Text Available Background: This paper analyzes progress made toward the integration of the French health care system for the older and chronically ill population. Policies: Over the last ten years, the French health care system has been principally influenced by two competing linkage models that failed to integrate social and health care services: local information and coordination centers, governed by the social field, and the gerontological health networks governed by the health field. In response to this fragmentation, Homes for the Integration and Autonomy for Alzheimer patients (MAIAs is currently being implemented at experimental sites in the French national Alzheimer plan, using an evidence-based model of integrated care. In addition, the state's reforms recently created regional health agencies (ARSs by merging seven strategic institutions to manage the overall delivery of care. Conclusion: The French health care system is moving from a linkage-based model to a more integrated care system. We draw some early lessons from these changes, including the importance of national leadership and governance and a change management strategy that uses both top-down and bottom-up approaches to implement these reforms.

  2. Holistic System of Care: a ten-year perspective.

    Science.gov (United States)

    Nebelkopf, Ethan; Wright, Serena

    2011-01-01

    The Holistic System of Care for Native Americans in an Urban Environment is a community-focused intervention that provides behavioral health care, promotes health, and prevents disease. This approach is based on a community strategic planning process that honored Native American culture and relationships. Substance abuse, mental illness, homelessness, poverty, crime, physical illness, and violence are symptoms of historical trauma, family dysfunction, and spiritual imbalance. The holistic model links treatment, prevention, and recovery. The link between prevention and treatment is early intervention. Peer support is the link between treatment and recovery. Recovering individuals serve as role models linking recovery to prevention. Culture and spirituality build a strong and resilient foundation for recovery. This article documents the effectiveness of the holistic model over a ten-year period that it has been implemented at the Family & Child Guidance Clinic of the Native American Health Center in the San Francisco Bay Area. The holistic model has produced statistically significant reductions in substance abuse among adult Native American women, men, reentry, and homeless populations; reductions in substance abuse among Native American adolescents; reductions in HIV/AIDS high-risk behavior among Native American men, women, and adolescents; and decreases in acting out behavior among Native American severely emotionally disturbed children.

  3. Foothills Model Forest: a ten-year review

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, R.

    2002-04-01

    The first ten years of the Foothills Model Forest, established in 1992, is reviewed. The model forest has been established to develop sustainable forest management within the broader concept of sustainable development and integrated resource management. The project focuses on issues such as wildlife habits and habitats; biodiversity monitoring; natural disturbance trends and patterns; and socio-economic studies. In Phase One of the Canadian Model Forest Network the Foothills Model Forest focused primarily on conducting world class research to advance the concept of sustainable forest management. Phase Two was devoted to communicating the results of that research, with a strong emphasis on generating baseline awareness of the concept of sustainable forest management and creating public awareness of the project's mandate in Alberta. Work during the next five years is expected to focus on demonstration and implementation of research results to forest managers and practitioners and others with a stake in the continued sustainability of Alberta's forests. The Sustainable Forest Management project shares a common objective with the Alberta Chamber of Resources' Integrated Landscape Management project; both projects recognise that reducing the industrial footprint is key to sustainable development. The emphasis on demonstration and implementation in the third phase of the Foothills Model Forest is expected to ensure continued sustainability of forests, ecosystems, communities and resources, with full recognition of the fact that the goal of sustainable development can be achieved only by full cooperation and integrated action of all stakeholders.

  4. Use of interactive lecture demonstrations: A ten year study

    Directory of Open Access Journals (Sweden)

    Ronald Thornton

    2010-10-01

    Full Text Available The widely held constructivist view of learning advocates student engagement via interactivity. Within the physics education research community, several specific interactive strategies have been developed to enhance conceptual understanding. One such strategy, the Interactive Lecture Demonstration (ILD is designed for large lecture classes and, if measured using specific conceptual surveys, is purported to provide learning gains of up to 80%. This paper reports on learning gains for two different Projects over ten years. In Project 1, the ILDs were implemented from 1999 to 2001 with students who had successfully completed senior high school physics. The learning gains for students not exposed to the ILDs were in the range 13% to 16% while those for students exposed to the ILDs was 31% to 50%. In Project 2, the ILDs were implemented from 2007 to 2009 with students who had not studied senior high school physics. Since the use of ILDs in Project 1 had produced positive results, ethical considerations dictated that all students be exposed to ILDs. The learning gains were from 28% to 42%. On the one hand it is pleasing to note that there is an increase in learning gains, yet on the other, we note that the gains are nowhere near the claimed 80%. This paper also reports on teacher experiences of using the ILDs, in Project 2.

  5. Wikis in education - After ten years of experience

    Directory of Open Access Journals (Sweden)

    Miran Hladnik

    2016-12-01

    Full Text Available In the recent ten years, the use of Wikimedia projects in classroom has become a daily necessity. On the Wikiversity subject pages, students can enroll into the seminar schedule, teachers can publish links to their educational resources and instructions, as well as summarize experiences. Students can document their activities on their personal Wikiversity pages, where they can also report about their assignments and exchange information with teachers and their peers. They often use Wikiversity as a sandbox, in order to sketch the encyclopedic entries for Wikipedia. They can link Wikiversity with Wikisource. The latter is a space to which they can upload the literary texts that are found in the national digital library. They can also correct the errors, which have been caused by OCR process, and equip the texts with metadata. Wikis thus force their users to depart from the school “ghetto” and enter the realm of their discipline through the participatory establishment of its sustainable, digital infrastructure. Considering the valuable potential that the wikis have in the context of the paradigm shift, during which competition retreats in favor of the participation and exchange, the article concludes that wikis are still insufficiently represented in the education processes.

  6. Lateral patellar retinacular release: changes over the last ten years.

    Science.gov (United States)

    Fonseca, Leonardo Pini Rosalem Marciano da; Kawatake, Ednei Haruo; Pochini, Alberto de Castro

    2017-01-01

    Lateral retinacular release is a useful resource in knee surgery that can be used for disorders of the extensor mechanism. For many years, it was indiscriminately used in the treatment of the various patellofemoral joint alterations, with conflicting functional results. This study aimed to analyze the changes that have occurred in the indications and clinical effectiveness of lateral retinacular release by reviewing the relevant literature of the past ten years, comparing it to the classic literature on the subject. It was found that less extensive releases decompress the lateral patellar facet, helping with pain control, while decreasing the risks of medial subluxation. Nowadays, there is clear evidence for its indication in the lateral patellar hypercompression syndrome associated with anterior knee pain, as long as there is no related instability; furthermore, it will normally play an adjuvant role in extensor mechanism alignment surgeries for cases of recurrent patellar instability. The initial results for symptomatic patellofemoral osteoarthritis are promising when lateral release is combined with cartilage debridement; in total knee replacement, it is more commonly used for the correction of valgus deformity in order to improve the components' congruency. Finally, distinguishing the different patellofemoral joint pathologies is seen as crucial in order to indicate this procedure. Further randomized control trials that compare surgical techniques with long-term results are still needed.

  7. Ten year neurocognitive trajectories in first-episode psychosis

    Directory of Open Access Journals (Sweden)

    Helene Eidsmo Barder

    2013-10-01

    Full Text Available Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP and the relationship to clinically significant subgroups even more so. We report 10 year longitudinal neurocognitive development in a sample of FEP patients, and explore whether the trajectories of cognitive course are related to presence of relapse to psychosis, especially within the first year, with a focus on the course of verbal memory.Method: Forty-three FEP subjects (51% male, 28±9 years were followed-up neurocognitively over five assessments spanning 10 years. The test battery was divided into four neurocognitive indices; Executive Function, Verbal Learning, Motor Speed, and Verbal Fluency. The sample was grouped into those relapsing or not within the first, second and fifth year. Results: The four neurocognitive indices showed overall stability over the ten year period. Significant relapse by index interactions were found for all indices except Executive Function. Follow-up analyses identified a larger significant decrease over time for the encoding measure within Verbal Memory for patients with psychotic relapse in the first year (F (4,38=5.8, p=0.001, η2=0.40Conclusions: Main findings are long-term stability in neurocognitive functioning in first episode psychosis patients, with the exception of verbal memory in patients with psychotic relapse or non-remission early in the course of illness. We conclude that worsening of specific parts of cognitive function may be expected for patients with on-going psychosis, but that most patients should expect no change in cognitive performance during the first 10 years after being diagnosed.

  8. The State of the Carbon Cycle: Ten Years On

    Science.gov (United States)

    King, A. W.; Dilling, L.; Fairman, D. M.; Houghton, R. A.; Marland, G.; Rose, A.; Wilbanks, T. J.; Zimmerman, G.

    2015-12-01

    It has been nearly ten years since the First State of the Carbon Cycle Report (SOCCR-1) was published in 2007. Much has changed in the intervening years, but much has remained the same. In anticipation of a Second State of the Carbon Cycle Report (SOCCR-2), we, the members of the SOCCR-1 Coordinating Team, felt that a perspective from the first SOCCR and reflection on changes in the state of carbon cycle science and policy in the intervening years would be appropriate. The purpose of SOCCR-1 was to provide "…a synthesis and integration of the current knowledge of the North American carbon budget and its context within the global carbon cycle [i]n a format useful to decision makers." Being "useful to decision makers" was a guiding theme with three stakeholder workshops an integral part of the process. Drafting and revision of SOCCR-1 took place between 2005 and early 2007; the report's carbon budget was for circa 2003. In 2003, North America's fossil-fuel CO2 emissions were approximately 27% of global emissions. Nearly 85% of North American emissions were from the US, still at that time the world's largest emitter of fossil-fuel CO2. China's annual CO2 emissions exceeded those of the US for the first time while SOCCR-1 was being written. Today global CO2 emissions are dominated by emissions from China (28% in 2013), with US emissions only 14% of global emissions. Emissions from the US and North America have actually declined by approximately 10% since 2003 while emissions from China have doubled. Based on inventories of terrestrial carbon stocks, SOCCR-1 estimated that circa 2003 North American vegetation removed and stored a net 500 Mt C y-1 (±50%) from the atmosphere. A more recent synthesis incorporating additional estimates from atmospheric inversions and terrestrial biosphere modeling estimated the North American land sink for the decade of 2000-2009 at 350-470 Mt C y-1, with a slightly greater uncertainty due to the wider range of estimates from the

  9. Cognitive development from two to ten years after pediatric epilepsy surgery.

    Science.gov (United States)

    Viggedal, Gerd; Kristjansdottir, Ragnhildur; Olsson, Ingrid; Rydenhag, Bertil; Uvebrant, Paul

    2012-09-01

    The development of cognitive functions and the sustainability of seizure control between two and ten years after epilepsy surgery were prospectively investigated in 17 children and adolescents. Intelligence quotient remained stable. Learning capacity improved. Verbal memory improved in half of the subjects and declined in half, whereas figurative memory declined in most patients. Working memory improved as did attention regarding sustained attention and impulse control. In contrast, reaction times were longer, and the auditory attention span was shorter. Executive functions were not affected. Six subjects (35%) were seizure free at the 10-year follow-up, and a seizure reduction of more than 75% had been achieved in 13 (76%). Seizure control improved in five and seizures recurred in two subjects between the two- and the 10-year follow-up.

  10. Pierre Bourdieu, dez anos depois Pierre Bourdieu, ten years after

    Directory of Open Access Journals (Sweden)

    Cristina Carta Cardoso de Medeiros

    2013-03-01

    Full Text Available O presente texto procura discutir o legado deixado pelo sociólogo francês Pierre Bourdieu. Dez anos após sua morte, tem-se discutido, em nível internacional, a relevância deste autor, um dos mais influentes e citados teóricos do mundo. Para a identificação desta influência no Brasil, mais especificamente no campo educacional brasileiro, pesquisou-se nas teses e dissertações encontradas no banco de dados da CAPES, que referenciavam Bourdieu, de que forma estaria se dando a apropriação de seu quadro teórico de análise para construção de conhecimento no referido campo. Concluiu-se que o número de produções defendidas nos Programas de Pós-Graduação em Educação no Brasil, de 1965 a 2010, cresce de forma exponencial, demonstrando o quão profícua a utilização da teoria sociológica de Bourdieu tem se mostrado para explicar a realidade da Educação no Brasil na contemporaneidade. Encerra-se o artigo com uma reflexão sobre a consideração do status de Bourdieu como um clássico da Sociologia que, paradoxalmente, se mostra mais atual e vivo do que qualquer outro autor quando se trata de aplicar seu princípio maior, a saber, analisar o mundo social e suas lógicas, desvelando as formas de dominação e as misérias sociais.This paper's intent is to discuss the legacy left by the French sociologist Pierre Bourdieu. Ten years after his death, it has been discussed at an international level the relevance of this author, one of the most cited and influential theorists in the world. To identify such influence in Brazil, more specifically in the Brazilian educational field, we investigated theses and dissertations found in CAPES database, which referenced Bourdieu, to identify how those works use his theoretical framework of analysis for construction of knowledge in that field. It was concluded that the number of productions held in post-graduate programs in education in Brazil, from 1965 to 2010, grows exponentially

  11. Retrospective evaluation of the five-year and ten-year CSEP-Italy earthquake forecasts

    Directory of Open Access Journals (Sweden)

    Stefan Wiemer

    2010-11-01

    Full Text Available On August 1, 2009, the global Collaboratory for the Study of Earthquake Predictability (CSEP launched a prospective and comparative earthquake predictability experiment in Italy. The goal of this CSEP-Italy experiment is to test earthquake occurrence hypotheses that have been formalized as probabilistic earthquake forecasts over temporal scales that range from days to years. In the first round of forecast submissions, members of the CSEP-Italy Working Group presented 18 five-year and ten-year earthquake forecasts to the European CSEP Testing Center at ETH Zurich. We have considered here the twelve time-independent earthquake forecasts among this set, and evaluated them with respect to past seismicity data from two Italian earthquake catalogs. We present the results of the tests that measure the consistencies of the forecasts according to past observations. As well as being an evaluation of the time-independent forecasts submitted, this exercise provides insight into a number of important issues in predictability experiments with regard to the specification of the forecasts, the performance of the tests, and the trade-off between robustness of results and experiment duration. We conclude with suggestions for the design of future earthquake predictability experiments.

  12. Giant vesical calculus in a ten year-old boy - a case report | Saleh ...

    African Journals Online (AJOL)

    Giant vesical calculus in a ten year-old boy - a case report. ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search · USING AJOL · RESOURCES ... revealed multiple radio-opaque calculi including a giant vesical calculus.

  13. Role of drinking water copper in pathogenesis of oral submucous fibrosis: a prospective case control study

    NARCIS (Netherlands)

    Arakeri, G.; Hunasgi, S.; Colbert, S.; Merkx, M.A.W.; Brennan, P.A.

    2014-01-01

    Although oral submucous fibrosis (OSMF) is thought to be multifactorial in origin, the chewing of areca nut is thought to be the main cause. Alkaloids and tannins in areca nut are responsible for fibrosis, but recent evidence has suggested that copper ions are also an important mediator, and in a sm

  14. Ten years of RELEA: achievements and challenges for astronomy education development

    Science.gov (United States)

    Bretones, Paulo Sergio; Jafelice, Luiz Carlos; Horvath, Jorge Ernesto

    2015-08-01

    When an area of education, and more particularly the research within this area, is aimed to development, a basic requirement is the existence of a regular publication that accounts for the scientific production in that area. This study aims to analyze 10 years of Latin-American Journal of Astronomy Education (RELEA). Publishing policies of the RELEA and their context are discussed in relation to submission, refereeing and publication. The 75 articles published in 18 editions are analyzed and classified by: year of publication, edition, the authors' institutions, school level, study focus and content. The results present trends and shortcomings of the production. A comparison with the number of articles published in other Brazilian journals of education and an analysis of the international scene in relation to other type publications along these ten years is made. Given that this journal is now consolidated, its future prospects in the international landscape are further considered. The challenges related to article submission are discussed: how to increase their number, the submission of Latin American countries, and how to bring in the issues and subjects not addressed until now. It is also considered the possibility of encouraging graduate studies, new lines of research in astronomy education, and dissemination of material in schools and universities for teachers and students. Finally, future possibilities are discussed given the IAU development programs. For example, more article submission from Portuguese-speaking countries with the support of Regional Nodes and Language Expertise Centers, and opportunities for volunteer IAU members and global projects for the development of astronomy education.

  15. Ten-year prospective study of public health problems associated with early drinking.

    Science.gov (United States)

    Ellickson, Phyllis L; Tucker, Joan S; Klein, David J

    2003-05-01

    To compare early nondrinkers, experimenters, and drinkers on the prevalence of problem behaviors at grades 7 and 12 and at age 23 (N = 6338, 4265, and 3369, respectively). Results are based on longitudinal self-report data from individuals who were originally recruited from 30 California and Oregon schools at grade 7 (1985) and assessed again at grade 12 (1990) and at age 23 (1995). Logistic regression was used to develop weighted estimates of the prevalence of academic difficulties, employment problems, substance use, and delinquent and violent behaviors within the 3 drinking status groups at grades 7, 12, and/or at age 23. Huber variance estimates, which adjust for weighting and clustering of observations, were used to assess the statistical significance of differences across groups. Early drinkers and experimenters were more likely than nondrinkers to report academic problems, substance use, and delinquent behavior in both middle school and high school. By young adulthood, early alcohol use was associated with employment problems, other substance abuse, and criminal and violent behavior. Early drinkers do not necessarily mature out of a problematic lifestyle as young adults. Interventions for these high-risk youth should start early and address their other public health problems, particularly their tendency to smoke and use other illicit drugs.

  16. [The family planning program in Rwanda: assessment of ten years (1981-1991) and prospects].

    Science.gov (United States)

    Munyakazi, A

    1990-12-01

    Rwanda's official family planning policy dates back to 1981 and creation of the National Office of Population (ONAPO). Among its other function, ONAPO monitors proper use of family planning methods and studies the integration of family planning services into public health. Pilot family planning programs began in the prefectures of Butare, Kigali, and Ruhengeri and were extended to the other 7 around 1985. The development of family planning services in Rwanda is based on their integration into existing services, especially those devoted to maternal-child health. In 1989, 277 of the 350 health centers of all kinds in Rwanda and 12 secondary posts offered family planning services. The rate of integration was 79.4%. 185 of the 277 health services with family planning services were in the public sector. As of December 1989, the rate of integration in different prefectures varied from a high of 95.5% in Kibungo to a low of 64.9% in Gisenyi. Integration is particularly weak in health facilities administered by the Catholic Church. The 2 strategies to confront this situation are continuing dialogue with Catholic Church officials and creation of secondary family planning posts to improve accessibility to family planning for populations served by Church health services. The number of new and continuing family planning users increased from 1178 and 1368 respectively in 1982 to 66,950 and 104,604 through September 1990. There is wide variation from 1 prefecture to another in recruitment of new acceptors and in the number of acceptors per health facility. Recruitment of new acceptors is greatest in Ruhengeri, followed by Kigali and Byumba. As of September 1990, 28,943 women used pills, 2037 used IUDs, 66,515 used injectables, 3051 used barrier methods, 2888 used auto-observation methods, 343 used implants, and 588 were sterilized. The overall rate of contraceptive prevalence increased from .9% in 1983 to 6.2% in 1989 and 10% in 1990. The strategy for promoting family planning has included training of personnel, improvement of supervision, regular supply of contraceptive equipment and supplies to health supervision, regular supply of contraceptive equipment and supplies to health centers, diversification of available methods, and addition of secondary family planning posts to improve accessibility. Obstacles still affecting Rwanda's family planning program include the pronatalist cultural orientation, which is being confronted by a vigorous IEC program. The reluctance of Catholic-affiliated health services to offer modern family planning methods, the shortage of trained family planning workers, contraceptive supply problems, and geographic inaccessibility of family planning services are other serious problems. To confront these problems, ONAPO plans to begin social marketing program, create more secondary health planning posts, promote integration of family planning services into the vaccination program, strengthen efforts to motivate postpartum women, and undertake a community distribution program for condoms and spermicides.

  17. The natural history and predictors of persistent problem behaviours in cystic fibrosis: a multicentre, prospective study.

    Science.gov (United States)

    Sheehan, Jane; Massie, John; Hay, Margaret; Jaffe, Adam; Glazner, Judith; Armstrong, David; Hiscock, Harriet

    2012-07-01

    In cystic fibrosis (CF), problems with sleep, eating/mealtime behaviours, physiotherapy adherence and parental mental health issues are common, yet their natural history and the extent of service use to address them are unknown. Follow up the 2007 cohort to determine: (1) prevalence of child sleep, eating/mealtime behaviours, physiotherapy adherence, and externalising/internalising problem behaviours and primary caregiver mental health status after a 3-year period; (2) natural history of child behaviours; (3) potentially modifiable predictors of persistent problems; and (4) service use for behaviours. Prospective cohort. Royal Children's Hospital, Monash Medical Centre and Sydney Children's Hospital (Australia) CF clinics. Caregivers, of children aged 3-8 years, who completed the baseline questionnaire. Child sleep, eating/mealtime behaviours, adherence with therapy and externalising and internalising behaviours. parenting style (low warmth), caregiver mental health status and sleep quality at baseline. 102 of 116 (88%) families participated. The prevalence of sleep and eating/mealtime problems at follow-up was similar to baseline. The prevalence of caregiver mental health symptoms remained higher than the community data. 71 out of 102 (70%) of the children experienced at least one persistent behaviour problem. Caregiver mental health difficulties predicted persistent child moderate to severe sleep problems (adjusted OR 6.5, 95% CI 1.2 to 36.2, p=0.03) and their persistently poor adherence to the physiotherapy regimen (adjusted OR 3.5, 95% CI 1.3 to 9.2, p=0.01). Child problem behaviours are common in children with CF, persist and are often predicted by the mental health of the parent. Routine surveillance for and management of child problem behaviours are recommended.

  18. Early Predictors of Ten-Year Course in First-Episode Psychosis

    DEFF Research Database (Denmark)

    Friis, Svein; Melle, Ingrid; Johannessen, Jan Olav

    2016-01-01

    OBJECTIVE: Identifying patients at risk of poor outcome at an early stage of illness can aid in treatment planning. This study sought to create a best-fit statistical model of known baseline and early-course risk factors to predict time in psychosis during a ten-year follow-up period after a first...... psychotic episode. METHODS: Between 1997 and 2000, 301 patients with DSM-IV nonorganic, nonaffective first-episode psychosis were recruited consecutively from catchment area-based sectors in Norway and Denmark. Specialized mental health personnel evaluated patients at baseline, three months, and one, two......, five, and ten years (N=186 at ten years). Time in psychosis was defined as time with scores ≥4 on any of the Positive and Negative Syndrome Scale items P1, P3, P5, P6, and G9. Evaluations were retrospective, based on clinical interviews and all available clinical information. During the first two years...

  19. TOJDE: Electronic Publishing and a Review of Ten Years' Experience in Turkey

    Science.gov (United States)

    Ozarslan, Yasin; Balaban-Sali, Jale; Demiray, Ugur

    2012-01-01

    This review examines "The Turkish Online Journal of Distance Education" (TOJDE) over a ten years period from 2000-2010. The study provides an opportunity to examine publishing activities such as number of published articles, authors, research topics and methods, and analyses of TOJDE's website such as time users stay on site and user…

  20. Indirect composite restorations luted with two different procedures: A ten years follow up clinical trial

    Science.gov (United States)

    Preti, Alessandro; Vano, Michele; Derchi, Giacomo; Mangani, Francesco; Cerutti, Antonio

    2015-01-01

    Objectives: The aim of this clinical trial was to evaluate posterior indirect composite resin restoration ten years after placement luted with two different procedures. Study Design: In 23 patients 22 inlays/onlays (Group A) were luted using a dual-cured resin composite cement and 26 inlays/onlays (Group B) were luted using a light cured resin composite for a total of 48 Class I and Class II indirect composite resin inlays and onlays. The restorations were evaluated at 2 time points: 1) one week after placement (baseline evaluation) and 2) ten years after placement using the modified USPHS criteria. The Mann-Whitney and the Wilcoxon tests were used to examine the difference between the results of the baseline and 10 years evaluation for each criteria. Results: Numerical but not statistically significant differences were noted on any of the recorded clinical parameters (p>0.05) between the inlay/onlays of Group A and Group B. 91% and 94 % of Group A and B respectively were rated as clinically acceptable in all the evaluated criteria ten years after clinical function. Conclusions: Within the limits of the study the results showed after ten years of function a comparable clinical performance of indirect composite resin inlays/onlays placed with a light cure or dual cure luting procedures. Key words:Light curing composite, dual curing composite, indirect composite restoration, inlays/onlays, clinical trial. PMID:25810842

  1. Mathematical Skills in Undergraduate Students. A Ten-Year Survey of a Plant Physiology Course

    Science.gov (United States)

    Llamas, A.; Vila, F.; Sanz, A.

    2012-01-01

    In the health and life sciences and many other scientific disciplines, problem solving depends on mathematical skills. However, significant deficiencies are commonly found in this regard in undergraduate students. In an attempt to understand the underlying causes, and to improve students' performances, this article describes a ten-year survey…

  2. Compromises in orchestra pit design: A ten-year trench war in The Royal Theatre, Copenhagen

    DEFF Research Database (Denmark)

    Gade, Anders Christian; Mortensen, Bo

    1998-01-01

    of opera finally opened the way for a new renovation of the pit, which solved most of the problems. The paper describes the many lessons learned during the ten-year period in which the authors were involved with the case as acoustic consultants. Questions of how pit configuration influences mutual hearing...

  3. Teacher Professional Development in "Teaching and Teacher Education" over Ten Years

    Science.gov (United States)

    Avalos, Beatrice

    2011-01-01

    A review of publications in "Teaching and Teacher Education" over ten years (2000-2010) on teacher professional development is the subject of the paper. The first part synthesises production referred to learning, facilitation and collaboration, factors influencing professional development, effectiveness of professional development and issues…

  4. Educational Virtual Environments: A Ten-Year Review of Empirical Research (1999-2009)

    Science.gov (United States)

    Mikropoulos, Tassos A.; Natsis, Antonis

    2011-01-01

    This study is a ten-year critical review of empirical research on the educational applications of Virtual Reality (VR). Results show that although the majority of the 53 reviewed articles refer to science and mathematics, researchers from social sciences also seem to appreciate the educational value of VR and incorporate their learning goals in…

  5. The Decline of Print: Ten Years of Print Serial Use in a Small Academic Medical Library

    Science.gov (United States)

    Rosati, Karen Thompson

    2006-01-01

    Tracking use of print journals over a ten-year period has allowed The University of South Carolina (USC) School of Medicine Library an essential tool for more accurate collection development, for both print and electronic selection. This lengthy study has provided usage statistics for purchasing decisions regarding electronic subscriptions still…

  6. Acute lower abdominal pain caused by adnexal torsion in a ten-year-old girl

    DEFF Research Database (Denmark)

    Steinthorsdottir, Kristin Julia; Hansen, Lars Folmer; Bisgaard, Thue

    2014-01-01

    A ten-year-old girl presented with four days of lower abdominal pain. A diagnostic laparoscopy on the suspicion of acute appendicitis revealed left-sided adnexal torsion. The cyanotic ovary was detorsed and recovered. At three-month follow-up there were no clinical or ultrasonic signs of patholog...

  7. Historical Evolution of Instructional Technology in Teacher Education Programs: A Ten-Year Update

    Science.gov (United States)

    Betrus, Anthony

    2012-01-01

    The content and emphasis of the introductory technology courses for undergraduate preservice teachers has historically been examined, with the earliest study conducted by Stracke in 1932. In an attempt to identify trends in the course DeKieffer conducted a series of studies over ten year intervals, in 1947, 1957, 1967, and 1977. In 2000 the first…

  8. Ten Years on: Does Graduate Student Promise Predict Later Scientific Achievement?

    Science.gov (United States)

    Haslam, Nick; Laham, Simon M.

    2009-01-01

    We examined publication records of 60 social psychologists to determine whether publication record at the time of the PhD (t0) predicted scientific achievement (publication quantity, quality, and impact) ten years later (t10). Publication quantity and quality each correlated moderately across this time-span. Productivity and impact at t10 were…

  9. Summary of Bilingual Teaching Research in Chinese Universities and Colleges during Ten Years

    Institute of Scientific and Technical Information of China (English)

    Wei Qiujie; Li Shaobo

    2008-01-01

    Based on the research papers dated from 1999 to 2008,on bilingual teaching in universities and colleges collected in the CNKI database,this paper presents the situation of bilingual teaching research during ten years,points out some shortcomings in the above papers,and then proposes some suggestions for the further research in bilingual teaching.

  10. Mathematical Skills in Undergraduate Students. A Ten-Year Survey of a Plant Physiology Course

    Science.gov (United States)

    Llamas, A.; Vila, F.; Sanz, A.

    2012-01-01

    In the health and life sciences and many other scientific disciplines, problem solving depends on mathematical skills. However, significant deficiencies are commonly found in this regard in undergraduate students. In an attempt to understand the underlying causes, and to improve students' performances, this article describes a ten-year survey…

  11. Adult and Continuing Education: The Next Ten Years. Information Series No. 114.

    Science.gov (United States)

    Grabowski, Stanley M.

    Futurism for adult and continuing education in the next ten years is the focus of this information analysis paper intended for adult educators and researchers. The paper is based on (1) literature practices in the field, (2) discussions with colleagues, (3) personal observations and experiences, (4) participation in futures conferences about adult…

  12. Trends and developments within corporate communication: an analysis of ten years of CCIJ

    NARCIS (Netherlands)

    Elving, W.J.L.

    2010-01-01

    Purpose This paper aims to analyse the trends in the papers which have been published in Corporate Communications: An International Journal (CCIJ ) over the past ten years. The analysis will focus on the region of the world the (first) authors come from and on the topics of the paper. Design/methodo

  13. Ten Years of bored tunnels in the Netherlands: Part I: Geotechnical issues

    NARCIS (Netherlands)

    Bakker, K.J.; Bezuijen, A.

    2008-01-01

    Ten years have passed since in 1997 for the first time construction of bored tunnels in the Netherlands soft soil was undertaken. Before that date essentially only immersed tunnels and cut-and-cover tunnels were constructed in the Netherlands. The first two bored tunnels were Pilot Projects, the 2nd

  14. Injection-molded 1-3 piezocomposite sensor development: The last ten years

    Science.gov (United States)

    Benjamin, Kim C.

    2005-04-01

    The past ten years have seen several interesting demonstrations of 1-3 piezocomposite when used as the active component in sonar sensors. Initially considered receive only by most in the field, piezocomposite has evolved into a proven broadband transducer material with both receive and transmit capability. From large aperture single element calibration transducers, to parametric mode projectors, the material has surprised many experts with its power handling capability. Its polymer constituent provides an amazing degree of versatility by allowing the thermoforming and shaping of transducer substrates for packaging into todays undersea vehicles. This talk will review the last ten years of piezocomposite transducer and array development focusing on both the materials transmit behavior and fabrication benefits for future sonar applications. [Work supported by the U.S. Navy.

  15. The State of the Art Ten Years After a State of the Art

    DEFF Research Database (Denmark)

    Sturm, Bob L.

    2014-01-01

    A decade has passed since the first review of research on a ``flagship application" of music information retrieval (MIR): the problem of music genre recognition (MGR). During this time, about 500 works addressing MGR have been published, and at least 10 campaigns have been run to evaluate MGR sys......, the problems of validity in evaluation also affect research in music emotion recognition and autotagging. We conclude by discussing the implications of our work for MGR and MIR in the next ten years....

  16. Early Predictors of Ten-Year Course in First-Episode Psychosis.

    Science.gov (United States)

    Friis, Svein; Melle, Ingrid; Johannessen, Jan Olav; Røssberg, Jan Ivar; Barder, Helene Eidsmo; Evensen, Julie Horgen; Haahr, Ulrik; Ten Velden Hegelstad, Wenche; Joa, Inge; Langeveld, Johannes; Larsen, Tor Ketil; Opjordsmoen, Stein; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per Wiggen; McGlashan, Thomas H

    2016-04-01

    Identifying patients at risk of poor outcome at an early stage of illness can aid in treatment planning. This study sought to create a best-fit statistical model of known baseline and early-course risk factors to predict time in psychosis during a ten-year follow-up period after a first psychotic episode. Between 1997 and 2000, 301 patients with DSM-IV nonorganic, nonaffective first-episode psychosis were recruited consecutively from catchment area-based sectors in Norway and Denmark. Specialized mental health personnel evaluated patients at baseline, three months, and one, two, five, and ten years (N=186 at ten years). Time in psychosis was defined as time with scores ≥4 on any of the Positive and Negative Syndrome Scale items P1, P3, P5, P6, and G9. Evaluations were retrospective, based on clinical interviews and all available clinical information. During the first two years, patients were also evaluated by their clinicians at least biweekly. Baseline and early-course predictors of long-term course were identified with linear mixed-model analyses. Four variables provided significant, additive predictions of longer time in psychosis during the ten-year follow-up: deterioration in premorbid social functioning, duration of untreated psychosis (DUP) of ≥26 weeks, core schizophrenia spectrum disorder, and no remission within three months. First-episode psychosis patients should be followed carefully after the start of treatment. If symptoms do not remit within three months with adequate treatment, there is a considerable risk of a poor long-term outcome, particularly for patients with a deterioration in premorbid social functioning, a DUP of at least half a year, and a diagnosis within the core schizophrenia spectrum.

  17. Ten-Year Mortality after a Breast Cancer Diagnosis in Women with Severe Mental Illness

    DEFF Research Database (Denmark)

    Ribe, Anette Riisgaard; Laurberg, Tinne; Laursen, Thomas Munk

    2016-01-01

    % higher for women with SMI and breast cancer (MRR: 4.27, 95% CI: 3.98-4.57). Among women with both disorders, 15% of deaths could be attributed to interaction. In a sub-cohort of women with breast cancer, the ten-year all-cause-mortality was 59% higher after taking tumor stage into account (MRR: 1.59, 95...... to diagnostics, provision of care for breast cancer or physical comorbidity, health-seeking-behavior, and adherence to treatment....

  18. Ten Years of the Sino-European Strategic Partnership: Achievements and Problems

    Directory of Open Access Journals (Sweden)

    Mingjin Wang

    2013-12-01

    Full Text Available Ten years after the establishment of the strategic partnership between China and the EU, this relationship has continued to flourish. However, publicly they have often been at odds, and even created doubts about the real existence of the comprehensive strategic partnership. The drawbacks of this relationship in recent years are mainly caused by the increased competitiveness in economy and trade, and the outbreak of quarrels concerning human rights and other areas. Since Sino-EU relations are very important for both parties and the world in general, both sides should find ways to control their conflicts and thus pave the way for their comprehensive strategic partnerships to further flourish.

  19. Colorectal carcinoma in a ten-year-old girl: A case report

    Directory of Open Access Journals (Sweden)

    Sarbani Chattopadhyay

    2012-01-01

    Full Text Available Colorectal carcinoma is very rare in childhood. In this case report, we depict a ten-year-old girl who presented with features of intestinal obstruction which turned out to be due to poorly differentiated mucin secreting adenocarcinoma of descending colon. Only increased awareness of this malignancy in this age-group and a high index of suspicion can help when a child complains of persistent pain of abdomen, altered bowel habits or rectal bleeding, and may provide diagnosis at an earlier stage, thereby improving the prognosis.

  20. Human Genomics in China——Ten Years Endeavor: From Planning to Implementation

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhu; ZHAO Guo-Ping

    2009-01-01

    @@ Ten years ago, the Chinese National Human Genome Center at Shanghai (South Center, hereafter) was es-tablished in the Zhangjiang HiTech Park of Pudong District in Shanghai. To commemorate this important event, which marks the beginning of the Genomics Era in China, we specially organize a series of mini-reviews for this special issue. We hope that this effort may draw the attention of the Chinese life science research workers to collectively recall the short but fruitful history of human genome project and coordinately explore the trend and goal of the future development of this academic discipline in China.

  1. Some developments of hot accretion flow theory in the past ten years

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The hot accretion flow model was re-discovered in 1994 by Narayan and collaborators.Intensive theoretical works have been conducted and significant progresses have been achieved.In this paper,we review several developments in the past ten years.This mainly includes the finding of outflow and convection and its dynamical effect on inflow;the direct electron heating by viscous dissipation;the effect of large scale toroidal magnetic fields in the inner region of the accretion flow;and the effect of global Compton scattering.Their observational applications are also introduced very briefly.

  2. Ten years of experience with transgastric necrosectomy for walled-off necrosis in acute pancreatitis

    DEFF Research Database (Denmark)

    Busse, Malene Just; Ainsworth, Alan Patrick

    2015-01-01

    INTRODUCTION: The aim of this study was to report our results with open transgastric necrosectomy for walled-off necrosis in acute pancreatitis over a period of ten years. METHODS: Patients operated at the department from 2003 until 2012 were studied retrospectively. RESULTS: A total of 50 patients......: Acute pancreatitis with walled-off necrosis has a high mortality rate. Need for additional therapy following necrosectomy was associated with fatal outcome. Endocrine and exocrine insufficiency was often seen at follow-up. FUNDING: none. TRIAL REGISTRATION: The study was approved by the Danish Data...

  3. Ten Years of GWOT, the Failure of Democratization, and the Fallacy of

    Directory of Open Access Journals (Sweden)

    David Oakley

    2012-01-01

    Full Text Available October 7, 2011, marked a decade since the United States invaded Afghanistan and initiated the Global War on Terrorism (GWOT. While most ten-year anniversary gifts involve aluminum, tin, or diamonds, the greatest gift U.S. policymakers can present American citizens is a reconsideration of the logic that guides America's counterterrorism strategy. Although the United States has successfully averted large-scale domestic terrorist attacks, its inability to grasp the nature of the enemy has cost it dearly in wasted resources and, more importantly, lost lives. Two of the most consistent and glaring policy flaws revolve around the concepts of filling "ungoverned spaces" and installing democracy by force.

  4. Ten-Year Trends in Children’s Caloric-Beverage Consumption and Behavioral Intent

    OpenAIRE

    Carnot MJ; Sutliffe JT; Palmer. SE; Elliott E

    2015-01-01

    Soft drinks, fruit juice and milk are the most common caloric-beverages consumed by adolescents and teens. We report the ten-year trends in the percentage of daily calories consumed in the form of caloric-beverages from a broad sample of fifth-grade students in the United States. This is a major area of concern related to dietary quality and body weight amongst children. The study was conducted from 2001-2011 through the Healthy Hearts for Kids (HH4K) online instructional ...

  5. Ten-Year Anniversary Workshop Young Scientists Summer Held in Beijing of NSFC-IIASA Program

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    On September 12th, 2012, Ten-Year Anniversary Workshop of NSFC-IIASA Young Scientists Sum- mer Program (YSSP) was held in NSFC. On behalf of the NSFC, Vice President, Prof. Wang Jie deliv- ered a speech at the opening ceremony. 50 or so participants including 4 scholars from the International In- stitute for Applied Systems Analysis (IIASA), researchers from relevant Chinese universities and institu- tions, representatives of the Bureau of International Cooperation and Department of Management Sciences of NSFC, attended the workshop.

  6. Idaho National Laboratory 2013-2022 Ten-Year Site Plan

    Energy Technology Data Exchange (ETDEWEB)

    Calvin Ozaki; Sheryl L. Morton; Elizabeth A. Connell; William T. Buyers; Craig L. Jacobson; Charles T. Mullen; Christopher P. Ischay; Ernest L. Fossum; Robert D. Logan

    2011-06-01

    The Idaho National Laboratory (INL) Ten-Year Site Plan (TYSP) describes the strategy for accomplishing the long-term objective of transforming the laboratory to meet Department of Energy (DOE) national nuclear research and development (R&D) goals, as outlined in DOE strategic plans. The plan links R&D mission goals and INL core capabilities with infrastructure requirements (single- and multi-program), establishs the 10-year end-state vision for INL complexes, and identifies and prioritizes infrastructure needs and capability gaps. The TYSP serves as the basis for documenting and justifying infrastructure investments proposed as part of the FY 2013 budget formulation process.

  7. Elastographic assessment of liver fibrosis in children: A prospective single center experience

    Energy Technology Data Exchange (ETDEWEB)

    Marginean, Cristina Oana, E-mail: marginean.oana@gmail.com [Department of Paediatrics, University of Medicine and Pharmacy of Tg. Mures (Romania); Marginean, Claudiu, E-mail: marginean.claudiu@gmail.com [Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Tg. Mures (Romania)

    2012-08-15

    Background: The assessment of liver damage in various disease states relies on a combination of clinical findings, biochemical parameters and invasive tests such as liver biopsy. The ultrasound elastography has emerged as a potential alternative test, providing quantifiable information on the elasticity/stiffness of the examined-tissues. We assessed the performance of ultrasound elastography using real-time Acoustic Radiation Force Imaging (ARFI) technology in evaluating the degree of liver fibrosis in children with and without liver disease. Methods: Children aged 0-18 years, hospitalized in the Emergency Clinical County Hospital Tg. Mures, Romania, between September 15, 2010 and January 15, 2011, were eligible for the study. Four groups were recruited as follow: patients with liver disease in the setting of various malignant disorders, children with non-malignant liver disease, overweight and obese children and healthy controls. The liver tissue elasticity was assessed in each individual using Shear Wave Velocity (SWV). Biochemical tests included transaminase levels. 19 children with chronic liver disease underwent biopsies. SWV was measured globally and separately for the liver-segments 1 and 8. Correlations between the SWV and laboratory test were established using non-parametric Spearman correlation test. Results: A total of 103 children underwent liver ultrasound elastographic assessments. Of these, 39 had malignancies, 19 had various chronic liver diseases, 13 had nonalcoholic fatty liver disease (NAFLD), and 32 were healthy controls. The transaminase values differed significantly between children with liver diseases and controls. In normal controls SWV values in the 1st segment were significantly lower compared to those in the in 8th segment of the liver (p = 0.0216). In the group with hepatic steatosis, the SWV values were statistically higher compared to those in healthy controls. Positive statistical correlations have been established between AST and SWV

  8. A Ten Year Audit of Maternal Mortality: Millennium Development Still a Distant Goal.

    Science.gov (United States)

    Singla, Anshuja; Rajaram, Shalini; Mehta, Sumita; Radhakrishnan, Gita

    2017-01-01

    To assess various causes of maternal mortality over a ten year period. Retrospective audit of hospital case records. Tertiary care hospital. Pregnant women who expired in the premises of GTB Hospital. A retrospective audit of case records of maternal deaths was conducted for a ten year period (January 2005 to December 2014). There were a total of 647 maternal deaths out of 1,16,641 live births. Sixty-eight percent (n = 445) of women were aged 21-30 years, while 10.5% (n = 68) were problem and improving the utilization of public health facilities. Preeclampsia/eclampsia and obstetric hemorrhage have been the main causes of maternal mortality for ages. Regular antenatal visits and the judicious training of grassroot level workers to pick-up complications early on in the pregnancy can be an effective way to deal the morbidity and mortality associated with these problems. The Janani Suraksha Yojana (JSY) and Janani Shishu Suraksha Karyakaram (JSSK) in India are pioneer steps in this direction.

  9. Scientific publications in pediatrics over the last ten years in Turkey and worldwide.

    Science.gov (United States)

    Altun, Demet; Dabak, Orçun; Hacıhamdioğlu, Duygu Övünç

    2015-01-01

    In keeping with the large area of interest comprised within the field of pediatrics, the number and diversity of publications in this field has gradually increased over the last ten years in our country as well as worldwide. The objective of this paper is to offer an analysis of the status of pediatrics publications during those ten years. The publications analyzed were listed in the Thomson Reuters Web of Science and/or published in journals included in the Science Citation Index, the Science Citation Index Expanded and the Social Sciences Citation Index. All of these publications appeared in journals in which at least one pediatrics specialist published between the years 2004 and 2013. It may be seen that Turkey is in fifth place worldwide in terms of the number of studies published in these journals, with 6,134 such publications. The conclusion is that it is necessary for more Turkish studies to be multicenter, to involve international participation and to receive more citations; importance must be attached to the objective of transforming of the knowledge produced by Turkish researchers into a greater number of publications of increased quality.

  10. Idaho National Laboratory 2015-2023 Ten-Year Site Plan

    Energy Technology Data Exchange (ETDEWEB)

    Sheryl Morton; Elizabeth Connell; Bill Buyers; John Reisenauer; Rob Logan; Chris Ischay; Ernest Fossum; Paul Contreras; Joel Zarret; Steve Hill; Jon Tillo

    2013-09-01

    This Idaho National Laboratory (INL) Ten-Year Site Plan (TYSP) describes the strategy for accomplishing the long-term objective of sustaining the INL infrastructure to meet the Department of Energy Office of Nuclear Energy (DOE-NE) mission: to promote nuclear power as a resource capable of making major contributions in meeting the nation’s energy supply, environmental and energy security needs. This TYSP provides the strategy for INL to accomplish its mission by: (1) linking R&D mission goals to core capabilities and infrastructure requirements; (2) establishing a ten-year end-state vision for INL facility complexes; (3) identifying and prioritizing infrastructure needs and capability gaps; (4) establishing maintenance and repair strategies that allow for sustainment of mission-critical (MC) facilities; and (5) applying sustainability principles to each decision and action. The TYSP serves as the infrastructure-planning baseline for INL; and, though budget formulation documents are informed by the TYSP, it is not itself a budget document.

  11. Floridi’s “Open Problems in Philosophy of Information”, Ten Years Later

    Directory of Open Access Journals (Sweden)

    Gordana Dodig Crnkovic

    2011-05-01

    Full Text Available In his article Open Problems in the Philosophy of Information [1] Luciano Floridi presented a Philosophy of Information research program in the form of eighteen open problems, covering the following fundamental areas: Information definition, information semantics, intelligence/cognition, informational universe/nature and values/ethics. We revisit Floridi’s program, highlighting some of the major advances, commenting on unsolved problems and rendering the new landscape of the Philosophy of Information (PI emerging at present. As we analyze the progress of PI we try to situate Floridi’s program in the context of scientific and technological development that have been made last ten years. We emphasize that Philosophy of Information is a huge and vibrant research field, with its origins dating before Open Problems, and its domains extending even outside their scope. In this paper, we have been able only to sketch some of the developments during the past ten years. Our hope is that, even if fragmentary, this review may serve as a contribution to the effort of understanding the present state of the art and the paths of development of Philosophy of Information as seen through the lens of Open Problems.

  12. A retrospective study of the pattern of sexually transmitted diseases during a ten-year period

    Directory of Open Access Journals (Sweden)

    Narayanan Beena

    2005-01-01

    Full Text Available Background: Proper knowledge of the patterns of sexually transmitted diseases (STDs in different geographical regions is necessary for evolving proper strategies for control of these diseases. Aims: To study the pattern of STDs and to analyze the changes during a ten-year period from 1990 among patients attending Medical College Hospital, Kottayam Methods: Case records of 686 patients with STDs who attended the outpatient wing of the Department of Dermatology and Venereology were studied. Results: There were 504 males and 182 females in the total of 686 patients. Marital contact alone was reported by 123 (67.6% female patients. Genital ulcer diseases (GUDs accounted for the maximum number of STDs, with 504 cases (73.5%, followed by condyloma acuminatum (17.5% and gonorrhea (10.1%. Forty-three patients had multiple infections. The total number of patients during the first year of study was 129, while it was 41 during the last year. Bacterial STDs showed a striking reduction in numbers. The decline was less marked in the case of viral STDs. Conclusion: The majority of patients had genital ulcer diseases. Spouses were the most common source of infection for female patients. There was a marked decline in the number of patients with various STDs during the ten-year period. The decline was more evident in the bacterial STDs resulting in an apparent increase of the viral STDs towards the end of the period of study.

  13. Primary localized conjunctival amyloidosis: A case report with a ten-year follow-up period

    Directory of Open Access Journals (Sweden)

    Juan Carlos Mesa-Gutiérrez

    2008-10-01

    Full Text Available Juan Carlos Mesa-Gutiérrez, Tomás Martí Huguet, Noemí Barnils Garcia, Jorge Arruga GinebredaDepartment of Ophthalmology, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Barcelona, SpainAbstract: A 57-year-old woman consulted our department about a plaque that had been present in her left eye for one year. Ophthalmological examination revealed a solid mass in the left conjunctival semilunar fold. An excitional biopsy was peformed, revealing an amyloid deposition. The patient was referred to the Internal Medicine Department for systemic study. All studies were negative for systemic amyloidosis. Throughout ten years of follow-up study, the patient has shown neither conjunctival recurrence nor any evidence of systemic amylodosis. Despite the fact that several authors have described ocular amyloidosis as an ophthalmologic manifestation of systemic amyloidosis, conjunctival location of amyloidosis is a very rare condition. Amyloid characterization in ocular structures should not be considered a final diagnosis since involvement of systemic underlying diseases must be ruled out. We report a case of localized conjunctival amyloidosis with a ten-year follow-up period that excluded ocular or systemic diseases.Keywords: conjuctival amyloidosis, ocular amyloidosis, hyaline protein

  14. Exercise-induced bronchospasm and atopy in Ghana: two surveys ten years apart.

    Directory of Open Access Journals (Sweden)

    Emmanuel O D Addo-Yobo

    2007-02-01

    Full Text Available BACKGROUND: Asthma and allergic diseases have increased in the developed countries. It is important to determine whether the same trends are occurring in the developing countries in Africa. We aimed to determine the time trend in the prevalence of exercise-induced bronchospasm (EIB and atopic sensitisation over a ten-year period in Ghanaian schoolchildren. METHODS AND FINDINGS: Two surveys conducted using the same methodology ten years apart (1993 and 2003 among schoolchildren aged 9-16 years attending urban rich (UR, urban poor (UP, and rural (R schools. Exercise provocation consisted of free running for six minutes. Children were skin tested to mite, cat, and dog allergen. 1,095 children were exercised in 1993 and 1,848 in 2003; 916 were skin tested in 1993 and 1,861 in 2003. The prevalence of EIB increased from 3.1% (95% CI 2.2%-4.3% to 5.2% (4.3%-6.3%; absolute percentage increase 2.1% (95% CI 0.6%-3.5%, p < 0.01; among UR, UP, and R children EIB had approximately doubled from 4.2%, 1.4%, and 2.2% to 8.3%, 3.0% and 3.9% respectively. The prevalence of sensitisation had also doubled from 10.6%, 4.7%, and 4.4% to 20.2%, 10.3%, and 9.9% (UR, UP, and R respectively. Mite sensitisation remained unchanged (5.6% versus 6.4%, but sensitisation to cat and dog increased considerably from 0.7% and 0.3% to 4.6% and 3.1%, respectively. In the multiple logistic regression analysis, sensitisation (odds ratio [OR] 1.77, 95% CI 1.12-2.81, age (OR 0.88, 95% CI 0.79-0.98, school (the risk being was significantly lower in UP and R schools: OR 0.40, 95% CI 0.23-0.68 and OR 0.54, 95% CI 0.34-0.86, respectively and year of the study (OR 1.73, 95% CI 1.13-2.66 remained significant and independent associates of EIB. CONCLUSIONS: The prevalence of both EIB and sensitisation has approximately doubled over the ten-year period amongst 9- to 16-year-old Ghanaian children irrespective of location, with both EIB and atopy being more common among the UR than the UP and R

  15. Prospective validation of FibroTest in comparison with liver stiffness for predicting liver fibrosis in Asian subjects with chronic hepatitis B.

    Directory of Open Access Journals (Sweden)

    Beom Kyung Kim

    Full Text Available Diagnostic values of FibroTest (FT for hepatic fibrosis have rarely been assessed in Asian chronic hepatitis B (CHB patients. We aimed to validate its diagnostic performances in comparison with liver stiffness (LS.From 2008 to 2010, 194 CHB patients who underwent liver biopsies along with FT and transient elastography were prospectively enrolled. Fibrosis stage was assessed according to the Batts and Ludwig system.To predict significant fibrosis (F≥2, advanced fibrosis (F≥3, and cirrhosis (F = 4, areas under receiver operating characteristic curves (AUROCs of FT were 0.903, 0.907, and 0.866, comparable to those of LS (0.873, 0.897, and 0.910, respectively. Optimized cutoffs of FT to maximize sum of sensitivity and specificity were 0.32, 0.52, and 0.68 for F≥2, F≥3, and F = 4, while those of LS were 8.8, 10.2, and 14.1 kPa, respectively. According to FT and LS cutoffs, 123 (63.4% and 124 (63.9% patients were correctly classified consistent with histological fibrosis (F1, F2, F3, and F4, respectively. Overall concordance between each fibrosis stage estimated by FT and LS was observed in 111 patients, where 88 were correctly classified with histological results. A combination formula adding LS to FT (LS+FT showed similar AUROC levels (0.885, 0.905, and 0.915, while another multiplying LS by FT (LS×FT showed the best AUROCs (0.941, 0.931, and 0.929 for F≥2, F≥3, and F4, respectively.FT provides good fibrosis prediction, with comparable outcomes to LS in Asian CHB patients. FT substantially reduces need for liver biopsy, especially when used in combination with LS.

  16. Lumacaftor and ivacaftor in the management of patients with cystic fibrosis: current evidence and future prospects.

    Science.gov (United States)

    Kuk, Kelly; Taylor-Cousar, Jennifer L

    2015-12-01

    Cystic fibrosis (CF) is a genetic disorder that causes multiorgan morbidity and premature death, most commonly from pulmonary dysfunction. Mutations in the CF transmembrane conductance regulator (CFTR) gene, of which almost 2000 have been described, result in a dysfunctional CFTR protein. This protein is an adenosine triphosphate binding anion channel, present primarily at the surface of epithelial cells. Loss of function mutations in this anion channel result in decreased or absent chloride/bicarbonate transport. The subsequent abnormal salt and water transport at epithelial cell surfaces leads to thickened secretions, and infection or inflammation in affected organs. In the last 20 years, therapeutics have been developed to treat the signs and symptoms of CF. However, in 2012, the small molecule drug, ivacaftor, became the first approved therapy that addresses the basic defect in CF. Ivacaftor is a potentiator of CFTR channels defective in their chloride/bicarbonate gating/conductance, but present at the epithelial cell surface. It is only approved for 10 mutations carried by approximately 7% of the population of patients with CF. F508del is the most common CFTR mutation, present in homozygosity in approximately 50% of patients with CF. The F508del mutation results in multiple CFTR channel defects that require both correction (stabilization of misfolded CFTR and trafficking to the epithelial cell membrane) and potentiation. This article reviews the in vitro and clinical trial data for the potential use of the potentiator, ivacaftor, and the corrector, lumacaftor, in patients with CF.

  17. Role of oxidative stress in the pathogenesis of oral submucous fibrosis: A preliminary prospective study

    Directory of Open Access Journals (Sweden)

    G K Shakunthala

    2015-01-01

    Full Text Available Background: In the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology. Enumerable data suggests that reactive oxygen species play a key role in multistage carcinogenesis. Oral submucous fibrosis (OSMF is considered as a potentially malignant disorder. Its increased incidence over recent years in the Indian subcontinent is a major health concern to oral physicians. However, the role of oxidative stress has not been widely investigated in OSMF. Aims: Is to evaluate both antioxidant and oxidant status in OSMF and to compare with controls. Settings and Design: Twenty patients and 20 controls of the same age group were enrolled in the study. Subjects and Methods: Five milliliters of blood were collected from each individual and serum was separated. Malondialdehyde (MDA estimation using thiobarbituric acid (TBA method, and antioxidant activity (AOA using principle of TBA reactive substances was done using this serum, with a calorimetric method. Statistical Analysis Used: Student's t-test and ANOVA test. Results: The mean serum AOA status was seen to significantly decrease in OSMF patients, as compared to controls (P = 0.013. The increase in mean serum MDA level was highly significant in OSMF patients, as compared to controls (P < 0.001. Conclusion: The disparity between AOA and MDA levels in the patients clearly demonstrates the role of oxidative stress in the disease process. The results also suggest the use of antioxidants in the management of OSMF.

  18. [Analysis of body mass index in different sector workers for over ten years].

    Science.gov (United States)

    Perbellini, L; Zonzin, C; Baldo, M

    2010-01-01

    A critical review of the literature on obesity and overweight underlines that a low educational level, a low social-economic status, certain working conditions, the lack of physical activity in leisure time, together with the availability of food, are the main factors favouring increased prevalence of obesity. Certain jobs also contribute significantly to this problem. Automation, the use of machines for heavy works and sedentary activities favour body weight increase. Jobs that are a source of stress, such as work with night shift can cause metabolic disorders leading to an increased prevalence of obesity. The main aim of this article is to study the trend of body weight in different working area during ten years, comparing this parameter to different factors such as job, blood pressure, smoke, alcool and health diseases.

  19. Ten Years of Monitoring 3C 273 with XMM–Newton

    Indian Academy of Sciences (India)

    Liu Liu; Youhong Zhang

    2011-03-01

    We present ten years optical/UV/X-ray observations of 3C 273 performed using XMM–Newton between 2000 and 2009. The short-time scale variability behaviour of the soft and hard X-ray light curves may suggest different origins of the soft/hard X-ray emissions. We fit well the 0.2–10 keV X-ray spectrum with a hard power-law component plus a soft Comptonization component. The lack of – correlation of the hard power-law component and the weakness of iron lines may support dominance of the jet component. The soft X-ray excess correlates much better with ultraviolet than with the hard power-law component, strongly suggesting that soft excess emission originates from inverse Comptonization of UV photons.

  20. Introduction to "Tsunami Science: Ten Years After the 2004 Indian Ocean Tsunami. Volume I"

    Science.gov (United States)

    Rabinovich, Alexander B.; Geist, Eric L.; Fritz, Hermann M.; Borrero, Jose C.

    2015-03-01

    Twenty-two papers on the study of tsunamis are included in Volume I of the PAGEOPH topical issue "Tsunami Science: Ten Years after the 2004 Indian Ocean Tsunami." Eight papers examine various aspects of past events with an emphasis on case and regional studies. Five papers are on tsunami warning and forecast, including the improvement of existing tsunami warning systems and the development of new warning systems in the northeast Atlantic and Mediterranean region. Three more papers present the results of analytical studies and discuss benchmark problems. Four papers report the impacts of tsunamis, including the detailed calculation of inundation onshore and into rivers and probabilistic analysis for engineering purposes. The final two papers relate to important investigations of the source and tsunami generation. Overall, the volume not only addresses the pivotal 2004 Indian Ocean (Sumatra) and 2011 Japan (Tohoku) tsunamis, but also examines the tsunami hazard posed to other critical coasts in the world.

  1. The church and society in South Africa celebrating first ten years of democracy (1994-2004

    Directory of Open Access Journals (Sweden)

    R T H Dolamo

    2005-10-01

    Full Text Available In this article, colonialism, slavery, racism and apartheid are singled out as scourges that have afflicted South Africans for over three-and-half centuries in respect of the first four scourge, and for four-and-half decades in respect of apartheid.� Against this backdrop, the struggles of the people of South Africa against these scourges are portrayed and analysed.� With the attainment of freedom and democracy in 1994, the� ANC led government enacted pieces of legislation whose aim was to deepen and broaden democracy, thereby transforming the society beyond recognition of how it was before 1994. Celebrating the first ten years of freedom and democracy, the people of South Africa are taking stock of what has been achieved and not achieved and bracing themselves for the challenges that are facing them into the second decade.

  2. French concessive connectives and argumentation: an experimental study in eight- to ten-year-old children.

    Science.gov (United States)

    Champaud, C; Bassano, D

    1994-06-01

    An experimental study examined the comprehension of sentences containing concessive connectives, considered from an argumentative-conclusive point of view, in eight- and ten-year-old French children (24 subjects in each age group). Two tasks were used: subjects had to choose between (1) opposite preceding contexts of sentences (context choice task), and (2) conclusions that could be drawn from the same sentences (conclusion choice task). Results indicated a clear developmental increase in performance. For all concessive items, except mais ('but'), results of the context choice task were better than results of the conclusion choice task. Older children gave significantly better responses for mais in the conclusion choice task. The ambivalence of the connective mais is discussed; comparisons with production and crosslinguistic data are suggested.

  3. Cross-discipline assessment during the ten-yearly inspection; 2. Expertise pluraliste en visite decennale

    Energy Technology Data Exchange (ETDEWEB)

    Sene, M. [Groupement de Scientifiques pour l' Information sur l' Energie Nucleaire (GSIEN), 75 - Paris (France)

    2009-07-15

    The French Group of Scientists for Information on Nuclear Energy (G.S.I.E.N.) has been mandated by the Fessenheim local commission for information and monitoring to carry out an assessment during the third ten-yearly inspections (VD3) of the Fessenheim nuclear power plant. This assessment, which began early in 2009, will be conducted over a period of one and a half years. The experts will submit their conclusions in mid-2010. Mrs. Sene, an expert with G.S.I.E.N. for the past 33 years, is coordinating the work of the expert group. She was involved in the previous assessments conducted by the Fessenheim local commission for information and monitoring. She explains the value of these assessments, as well as the limitations of such efforts. (author)

  4. Health evaluation of the 2nd International "Quit and Win" Antinicotine Campaign participants ten years later.

    Science.gov (United States)

    Kowalska, Alina; Stelmach, Włodzimierz; Krakowiak, Jan; Rzeźnicki, Adam; Pikala, Małgorzata; Dziankowska-Zaborszczyk, Elzbieta; Drygas, Wojciech

    2008-01-01

    Smoking is one of the most often noticed types of negative behaviour among the Poles. In the work, the results of the health evaluation are presented of the participants of the 'Quit and Win' competition ten years after making a decision to refrain from smoking, also the dependency between this evaluation and behaviour connected with smoking among the people living in big cities and small towns and villages was analysed. Among the 648 respondents, majority, which is 302 people (46.6%) evaluated their health as good, 236 (36.4%) as average, and 76 of the questioned (11.7%) as very good, 29 people (4.5%) as bad, and 5 of the questioned (0.8%) as very bad. The respondents most often evaluated negatively their health in the group of the still smoking living in the big cities, and the least often in the group of the non-smokers living in small towns and villages.

  5. Ten-year progress of Chinese polar geodesy:1996-2006

    Institute of Scientific and Technical Information of China (English)

    Oongchen E; Shengkai ZHANG; Chunxia ZHOU

    2008-01-01

    The ten-year progress of Chinese polar geodesy from 1996 to 2006 is summarized.Research on plate motion,crustal movement,orbit determination,and atmospheric monitoring,including the ionosphere and troposphere,were performed using GPS data of the Great Wall Station,Zhongshan Station and Yellow River Station.GPS was also applied in the Amery Ice Shelf,Grove Mountains and Dome A expeditions to study ice dynamics.During the 2004/2005 austral summer season,the absolute gravity and relative gravity were measured at the Great Wall Station with precision within + 3 × 10-8 ms-2 and + 10×10-8 ms-2 respectively.The tide gauge,which was set up in Zhongshan Station to monitor sea level change in 2000,recorded the 2004 Indian Ocean tsunami.SAR interferometry was applied to build the DEM of ice sheet and monitor ice flow in the polar region.

  6. [High school students and their knowledge about HIV/AIDS: what has changed in ten years?].

    Science.gov (United States)

    do Val, Luciane Ferreira; deSouza Silva, José Augusto; Rincón, Laura Alarcón; Lima, Renata Holanda dos Anjos; Barbosa, Ricardo Luis; Nichiata, Lucia Yazuko Izumi

    2013-06-01

    An exploratory, descriptive, comparative study with a quantitative approach, whose objective was to compare the knowledge of high school students from two public state schools of Peruíbe, SP, Brazil, about Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS), in the years 1999 and 2010. In both of these years, the predominant population studied was female students, under 18 years old, unmarried and white. A statistically significant difference was found with respect to knowledge about HIV/AIDS among the groups studied. It was found that even with ten-year interval between the studies, the two groups of students did not consider themselves vulnerable to HIV and presented doubts as to the correct knowledge about the topic, which indicates the need for a continuous approach with young adolescents.

  7. Perspective: The first ten years of broadband chirped pulse Fourier transform microwave spectroscopy

    Science.gov (United States)

    Park, G. Barratt; Field, Robert W.

    2016-05-01

    Since its invention in 2006, the broadband chirped pulse Fourier transform spectrometer has transformed the field of microwave spectroscopy. The technique enables the collection of a ≥10 GHz bandwidth spectrum in a single shot of the spectrometer, which allows broadband, high-resolution microwave spectra to be acquired several orders of magnitude faster than what was previously possible. We discuss the advantages and challenges associated with the technique and look back on the first ten years of chirped pulse Fourier transform spectroscopy. In addition to enabling faster-than-ever structure determination of increasingly complex species, the technique has given rise to an assortment of entirely new classes of experiments, ranging from chiral sensing by three-wave mixing to microwave detection of multichannel reaction kinetics. However, this is only the beginning. Future generations of microwave experiments will make increasingly creative use of frequency-agile pulse sequences for the coherent manipulation and interrogation of molecular dynamics.

  8. Perspective: The first ten years of broadband chirped pulse Fourier transform microwave spectroscopy.

    Science.gov (United States)

    Park, G Barratt; Field, Robert W

    2016-05-28

    Since its invention in 2006, the broadband chirped pulse Fourier transform spectrometer has transformed the field of microwave spectroscopy. The technique enables the collection of a ≥10 GHz bandwidth spectrum in a single shot of the spectrometer, which allows broadband, high-resolution microwave spectra to be acquired several orders of magnitude faster than what was previously possible. We discuss the advantages and challenges associated with the technique and look back on the first ten years of chirped pulse Fourier transform spectroscopy. In addition to enabling faster-than-ever structure determination of increasingly complex species, the technique has given rise to an assortment of entirely new classes of experiments, ranging from chiral sensing by three-wave mixing to microwave detection of multichannel reaction kinetics. However, this is only the beginning. Future generations of microwave experiments will make increasingly creative use of frequency-agile pulse sequences for the coherent manipulation and interrogation of molecular dynamics.

  9. [Ten years of external control over water fluoridation in Chapecó, Santa Catarina State, Brazil].

    Science.gov (United States)

    Panizzi, Mirvaine; Peres, Marco Aurélio

    2008-09-01

    This study aimed to analyze fluoride concentration in the public water supply in Chapecó, Santa Catarina State, Brazil, from 1995 to 2005 and to assess the effectiveness of a fluoridation quality intervention in 2003. A total of 989 water samples were analyzed. Fluoride concentrations were classified according to three different criteria used in Brazil. The city conducted a political and legal intervention in 2003. The Prais-Winsten procedure was used to evaluate the fluoride concentrations over time. In the ten years, the water fluoridation system showed 46%, 32%, and 43% of adequate samples, depending on the criterion. Prior to the municipal intervention, the proportion of adequate samples was 40%, 26%, and 36%, increasing to 63%, 49%, and 61% after the intervention, according to the three criteria. Fluoride concentration improved after the municipal intervention. On-going surveillance is recommended, including water fluoridation, dental caries, and dental fluorosis.

  10. Educational virtual environments: A ten-year review of empirical research (1999-2009)

    DEFF Research Database (Denmark)

    Mikropoulos, Tassos; Natsis, Antonios

    2011-01-01

    This study is a ten-year critical review of empirical research on the educational applications of Virtual Reality (VR). Results show that although the majority of the 53 reviewed articles refer to science and mathematics, researchers from social sciences also seem to appreciate the educational...... value of VR and incorporate their learning goals in Educational Virtual Environments (EVEs). Although VR supports multisensory interaction channels, visual representations predominate. Few are the studies that incorporate intuitive interactivity, indicating a research trend in this direction. Few...... present real world, authentic tasks that enable context and content dependent knowledge construction. They also provide multiple representations of reality by representing the natural complexity of the world. Findings show that collaboration and social negotiation are not only limited to the participants...

  11. Idaho National Laboratory Ten-Year Site Plan Project Description Document

    Energy Technology Data Exchange (ETDEWEB)

    Not Listed

    2012-03-01

    This document describes the currently active and proposed infrastructure projects listed in Appendix B of the Idaho National Laboratory 2013-2022 Ten Year Site Plan (DOE/ID-11449). It was produced in accordance with Contract Data Requirements List I.06. The projects delineated in this document support infrastructure needs at INL's Research and Education Campus, Materials and Fuels Complex, Advanced Test Reactor Complex and the greater site-wide area. The projects provide critical infrastructure needed to meet current and future INL opereational and research needs. Execution of these projects will restore, rebuild, and revitalize INL's physical infrastructure; enhance program execution, and make a significant contribution toward reducing complex-wide deferred maintenance.

  12. Ten-year results of phototherapeutic keratectomy on recurrent corneal erosions

    Directory of Open Access Journals (Sweden)

    Belquiz Rodrigues do Amaral Nassaralla

    2012-02-01

    Full Text Available PURPOSE: To determine the ten-year visual results and outcomes of excimer laser phototherapeutic keratectomy (PTK for recurrent corneal erosions. METHODS: Twenty-six eyes of 23 patients with recurrent corneal erosions were treated by PTK from 1996 to 2000 at the Goiania Eye Institute, Brazil. All eyes had failed to respond to conventional therapy. Data regarding preoperative and postoperative best-spectacle-corrected visual acuity (BSCVA, spherical equivalent (SE, symptomatic relief, incidence of recurrence, and complications arising from the laser treatment were analyzed. The mean duration of symptoms prior to PTK was 18 months (range, 8 to 36 months. The corneal epithelium was debrided, and laser ablation was performed to a depth of 5 micron with an ablation zone of 7 to 9 mm, using the Technolas 217C Plano Scan excimer laser. Mean postoperative follow-up was 12 years (range, 10 to 14 years. RESULTS: At the last follow-up visit, 15 eyes (57.69% were symptomsfree. Five eyes (19.2% had occasional mild symptoms of irritation and photophobia upon awakening. Recurrence of painful corneal erosions occurred in six eyes (23.07%, which required a PTK retreatment. Twenty-four eyes had a preserved or improved BCVA, while 2 eyes showed deterioration of 1 line on Snellen test. Eleven eyes (42.3% had no change in SE, and the others (57.69% had a change of less than +/-0.75 diopters (D. There were no major complications during the follow-up period. CONCLUSION: Ten-year data show that PTK is a safe, fast, effective and minimal invasive choice of treatment for recurrent corneal erosions in patients who do not respond to conventional treatments.

  13. Clinical tolerance in large field radiotherapy--the knowledge gained over the last ten years.

    Science.gov (United States)

    Gocheva, Lilia B

    2010-01-01

    Malignant disorders are still far from being successfully managed in spite of the apparent progress achieved by surgical treatment, high energy radiotherapy (RT) and chemotherapy (CHT). They keep being the second most frequent cause of lethal outcomes both in Bulgaria and in most countries of the world. One of the promising approaches to increasing the efficaciousness of treatment is development and use of methods that are in full accord with the modern requirements of a complex therapy. Over the last fifty years, large field radiation techniques, applied as systemic therapy in oncology, have been investigated and established. These techniques show the transition in oncology to using actively various variants of large field radiotherapy (LFR), the "heavy artillery" of oncoradiologic practice, as an alternative or adjunct therapy to chemotherapy (CHT). In the present paper we review the current knowledge in the field and present the clinical experience accumulated over the last ten years with respect to clinical tolerance in the major large-field radiotherapy techniques--total body irradiation, half body irradiation, whole abdominal irradiation, total and partial lymphoid irradiation. Described in detail are the contemporary knowledge about clinical and hematologic tolerance in total body irradiation as part of the myelo- and nonmyeloablative conditioning regimens as well as in half body irradiation as a systemic therapy in oncology. We also present the amassed experience in clinical tolerance in partial body irradiation in the form of whole abdominal and total or partial lymphoid irradiation. Another point worth noting based again on the experience gained over the last ten years is that for LFR we need to develop a radiotherapy technique that is designed carefully to achieve an optimal therapeutic effect that should include the disease control, good clinical tolerance and reduction of post-radiotherapy sequelae.

  14. Medical School Attrition-Beyond the Statistics A Ten Year Retrospective Study

    Directory of Open Access Journals (Sweden)

    Maher Bridget M

    2013-01-01

    Full Text Available Abstract Background Medical school attrition is important - securing a place in medical school is difficult and a high attrition rate can affect the academic reputation of a medical school and staff morale. More important, however, are the personal consequences of dropout for the student. The aims of our study were to examine factors associated with attrition over a ten-year period (2001–2011 and to study the personal effects of dropout on individual students. Methods The study included quantitative analysis of completed cohorts and qualitative analysis of ten-year data. Data were collected from individual student files, examination and admission records, exit interviews and staff interviews. Statistical analysis was carried out on five successive completed cohorts. Qualitative data from student files was transcribed and independently analysed by three authors. Data was coded and categorized and key themes were identified. Results Overall attrition rate was 5.7% (45/779 in 6 completed cohorts when students who transferred to other medical courses were excluded. Students from Kuwait and United Arab Emirates had the highest dropout rate (RR = 5.70, 95% Confidence Intervals 2.65 to 12.27;p  Absenteeism was documented in 30% of students, academic difficulty in 55.7%, social isolation in 20%, and psychological morbidity in 40% (higher than other studies. Qualitative analysis revealed recurrent themes of isolation, failure, and despair. Student Welfare services were only accessed by one-third of dropout students. Conclusions While dropout is often multifactorial, certain red flag signals may alert us to risk of dropout including non-EU origin, academic struggling, absenteeism, social isolation, depression and leave of absence. Psychological morbidity amongst dropout students is high and Student Welfare services should be actively promoted. Absenteeism should prompt early intervention. Behind every dropout statistic lies a personal story. All

  15. Periurethral fibrosis secondary to prostatic inflammation causing lower urinary tract symptoms: a prospective cohort study.

    Science.gov (United States)

    Cantiello, Francesco; Cicione, Antonio; Salonia, Andrea; Autorino, Riccardo; Tucci, Luigi; Madeo, Immacolata; Damiano, Rocco

    2013-05-01

    To investigate the role periurethral fibrosis secondary to chronic prostatic inflammation as a potential contributing factor to the etiology of lower urinary tract symptoms (LUTS) in male patients. Periurethral prostate tissue from 30 consecutive patients who underwent retropubic radical prostatectomy for prostate cancer was analyzed. We circumferentially performed 16 periurethral core bench biopsies on each radical prostatectomy specimen to evaluate the extent of periurethral inflammatory infiltrate and collagen and elastin amount. The clinical and urodynamic findings and the collagen and elastin periurethral amount in patients with or without inflammation were compared using the Mann-Whitney U test and the Pearson χ(2) test. Spearman correlation analysis tested the association between variables. Of the 30 patients, 21 (70%) presented with inflammatory infiltration and 9 (30%) had no inflammation. A significant difference was found between the 2 groups in International Prostate Symptom Score (IPSS; P = .03) and in urodynamics findings by Schafer class (P = .01) and Abrams Griffiths number (P = .002). The histologic evaluation showed a higher collagen quantity (P = .04) and lower, albeit not statistically significant, elastin amount (P = .19) in the inflammation group. A positive association was observed between IPSS with inflammation grading (r = 0.507; P = .004) and collagen content (r = 0.649; P Prostate inflammation may induce fibrotic changes in periurethral prostatic tissues, and this may eventually promote urethral stiffness and LUTS. Patients experiencing prostate-related LUTS could benefit from anti-inflammatory therapies, used alone or combined with the currently prescribed regimen. Copyright © 2013 Elsevier Inc. All rights reserved.

  16. Investigating significant health trends in idiopathic pulmonary fibrosis (INSIGHTS-IPF): rationale, aims and design of a nationwide prospective registry.

    Science.gov (United States)

    Behr, Juergen; Hoeper, Marius M; Kreuter, Michael; Klotsche, Jens; Wirtz, Hubert; Pittrow, David

    2014-01-01

    Guidelines on the diagnosis and management of idiopathic pulmonary fibrosis (IPF), a rare manifestation of chronic progressive fibrosing interstitial pneumonia, have been updated by ATS/ERS/JRS/ALAT in 2011. In Europe, data are limited on the characteristics and management of such patients. Investigating significant health trends (INSIGHTS)-IPF is a prospective observational longitudinal registry designed to describe the characteristics and management of newly diagnosed (incident) and prevalent patients with IPF on the long term. The registry uses a non-probability sampling approach to collect data on characteristics, therapeutic interventions, health-related quality of life and health economic parameters. At least 500 patients in ambulatory care will be included consecutively in about 30 centres. The study has been initiated in November 2012, and currently (December 2013) follows 344 patients. ClinTrials.gov identifier is NCT01695408. INSIGHTS-IPF documents one of the largest IPF cohorts in Europe. The registry is expected to provide much-needed data on the characteristics and management situation of patients with IPF in Germany. It will allow comparisons with other countries. Gap analyses based on current guidelines for management of these patients will be possible.

  17. Etiology and outcome of fetal echogenic bowel. Ten years of experience.

    Science.gov (United States)

    Kesrouani, Assaad K; Guibourdenche, Jean; Muller, Françoise; Denamur, Eric; Vuillard, Edith; Garel, Catherine; Delezoide, Anne Lise; Eydoux, Patrice; Tachdjian, Gerard; Lebon, Pierre; de Lagausie, Pascal; Sibony, Olivier; Bauman, Clarisse; Oury, Jean-François; Luton, Dominique

    2003-01-01

    To assess the frequency of certain etiologies in fetal echogenic bowel and the related pregnancy outcome. A retrospective study including 215 cases. Ultrasound findings included bowel abnormality, malformations, growth retardation and Doppler abnormalities. Amniocentesis was performed in 196 cases to screen for abnormalities in karyotype, cystic fibrosis gene and infection. The color of amniotic fluid and a history of first-trimester bleeding were also noted. Outcome according to different etiologies was reported. 112 cases (57%) had a known etiology, which included chromosomal abnormality (7%), infection (4%), cystic fibrosis (1.5%), bowel abnormality (3%), bleeding or stained amniotic fluid (11%), Doppler abnormality (14%), malformation (16%) and miscellaneous (0.5%). Pregnancy was terminated in 39 cases and fetal demise complicated one third of the cases (13) of severe growth retardation. Fetal echogenic bowel should be investigated and a careful follow-up is necessary if there is associated Doppler perturbation or growth retardation. Copyright 2003 S. Karger AG, Basel

  18. Ten Years, Twenty Issues, and Two Hundred Papers of Numeracy: Toward International Reach and Transdisciplinary Utility

    Directory of Open Access Journals (Sweden)

    H.L. Vacher

    2017-07-01

    Full Text Available This issue completes the first ten years of Numeracy. The purpose of this introductory editorial is to review what has happened to the journal in those ten years. In the twenty issues, Numeracy’s output has been 201 papers counting the one or two editorials per issue. More than 50% of the papers are full, peer-reviewed articles, including 13 papers in two theme collections. The others are peer-reviewed notes and perspectives, editor-reviewed book reviews (15% of the total, and a column by contributing co-editor, Dorothy Wallace. The current issue marks an upswing in the number of notes, and our first discussion/reply. The number of papers per year has been increasing (e.g., 66% more in the last three years than in the first three years. The download rate has increased from about 5,000 in the first two years to 5,000 in about 40 days now. The editorial goes on to document two main outcomes. First, the journal is gaining an international reach: more than half the downloads occur outside the United States now, and the number of contributions from outside the United States has increased from 4 in the first five years to 15 in the second five years. Second, the across-the-curriculum nature of quantitative literacy is coming to the fore. The transdisciplinarity of QL is strikingly evident in this issue, which is discussed in some detail, especially how it conforms to the mission of the Association of American Colleges and Universities. The editorial ends with some results from a small ad hoc study of Google Scholar Citation Profiles. The question was, of the profiles that used “numeracy” or “quantitative literacy” as keywords, what other keywords did those profiles use, and what were the source countries? The results show that (1 QL is very much an American term, (2 there is, metaphorically, a vast and interesting numeracy ecosystem out there for Numeracy to engage and serve, and (3 as we become more global, the transdisciplinary relevance

  19. Ten-year results of a comparison of methods for restoring afforested blanket bog

    Directory of Open Access Journals (Sweden)

    R. Anderson

    2017-02-01

    Full Text Available There is growing interest in the restoration of blanket bogs that were afforested during the 1960s to 1980s, to avoid further loss of carbon to the atmosphere and to regain and defragment important blanket bog habitat. This paper reports the findings from a ten-year experiment in the UK to test the effectiveness of restoration treatments on water table depth, peat bulk density and water content, ground surface height and vegetation development. Treatments used were the six combinations of damming or not damming plough furrows with leaving the trees alive, felling and leaving them on the ground or felling and removing them. Combining felling with damming furrows was most successful in raising the water table, whether or not the felled trees were removed. Only where felling was combined with damming did the water table continue to recover between Years 5 and 10. Over ten years, the water level in these treatments rose to slightly below that of non-afforested reference bog at the same sites. This occurred as a rapid initial rise, following which there was only very slight further improvement. Felling caused the species composition of the vegetation to change towards that of the reference bogs. The process was slow, with the vegetation becoming more dissimilar to non-forested reference bog in the first five years and then becoming more similar to the reference bog after Year 5. Surprisingly, damming plough furrows had little effect on the vegetation except that, in combination with felling, it increased differentiation between the plough furrows and other positions on the ploughed ground. Conifer seedlings established on the restored plots, most densely where they adjoined standing forest, and had similar density and growth in all the felled treatments. The restoration treatments resulted in a decrease in bulk density and increase in water content of the upper peat, probably due to an unloading effect caused by the raised water table buoying up the

  20. Medical School Attrition-Beyond the Statistics A Ten Year Retrospective Study

    Science.gov (United States)

    2013-01-01

    Background Medical school attrition is important - securing a place in medical school is difficult and a high attrition rate can affect the academic reputation of a medical school and staff morale. More important, however, are the personal consequences of dropout for the student. The aims of our study were to examine factors associated with attrition over a ten-year period (2001–2011) and to study the personal effects of dropout on individual students. Methods The study included quantitative analysis of completed cohorts and qualitative analysis of ten-year data. Data were collected from individual student files, examination and admission records, exit interviews and staff interviews. Statistical analysis was carried out on five successive completed cohorts. Qualitative data from student files was transcribed and independently analysed by three authors. Data was coded and categorized and key themes were identified. Results Overall attrition rate was 5.7% (45/779) in 6 completed cohorts when students who transferred to other medical courses were excluded. Students from Kuwait and United Arab Emirates had the highest dropout rate (RR = 5.70, 95% Confidence Intervals 2.65 to 12.27;p students combined. North American students had a higher dropout rate than Irish and EU students; RR = 2.68 (1.09 to 6.58;p = 0.027) but this was not significant when transfers were excluded (RR = 1.32(0.38, 4.62);p = 0.75). Male students were more likely to dropout than females (RR 1.70, .93 to 3.11) but this was not significant (p = 0.079). Absenteeism was documented in 30% of students, academic difficulty in 55.7%, social isolation in 20%, and psychological morbidity in 40% (higher than other studies). Qualitative analysis revealed recurrent themes of isolation, failure, and despair. Student Welfare services were only accessed by one-third of dropout students. Conclusions While dropout is often multifactorial, certain red flag signals may alert us to risk of

  1. Prognostic factors in children with acute lymphoblastic leukemia: a ten year study

    Directory of Open Access Journals (Sweden)

    Oloomi yazdi Z.

    2008-06-01

    Full Text Available Background: Acute lymphoblastic leukemia (ALL is the most common cancer in the pediatric population. With modern treatments, the chance of the complete recovery is nearly 100%. The most important prognostic factors are appropriate treatment protocol and determination of patient risk factors based on clinical, morphological, immunological and cytological characteristics. In this study we reviewed frequency of these factors, like as age, gender, the primary white blood cell number, sub- group on the base of FAB classification, immunophenotype and the clinical progress. Methods: In this retrospective study, we reviewed 877 pediatric patients with the diagnosis of ALL between the years of 1994 and 2004. In these patients the age, gender, primary WBC count, sub-group based on the FAB classification, immunophenotype and the clinical progress in 177 patient with acute lymphoblastic leukemia at Imam Khomeini Hospital between the years of 1994 to 2004 were determined. Results: Of these patients, 1.6% was younger than one year, 24.8% more than ten years old and 73.6% were between the ages of one and ten years; 63.8% were male. WBC counts were above 50,000/ul in 28.8% of the patients. FAB classifications included L1 in 80.2%, L2 in 17.5% and L3 in 2.3% of the patients. Immunophenotypes included pre-B cell in 63.8%, early pre-B cell in 23.1%, T cell in 12.3% and mature B cell in 0.8% of the patients. Marker CD10+ was detected in 88.1% of the B cell cases. In this study group, 74% of the patients recovered, 16.3% died and 16.5% relapsed.Conclusions: The prevalence of FAB-L1 and pre-B cell cases in this study is greater than a previous study, while the prevalence of FAB-L2 and early pre-B cell cases is less than that of the previous study.

  2. Ten Years Back, Five Years Forward: The Data Seal of Approval

    Directory of Open Access Journals (Sweden)

    Ingrid Dillo

    2015-02-01

    Full Text Available If we want to share data, the long-term storage of those data in a trustworthy digital archive is an essential condition. Trust is the basis of storing and sharing data. That trust must be present in the various stakeholders involved. Certification of digital archives can make an important contribution to the confidence of these stakeholders in the digital archives.Ten years ago DANS was assigned the task of developing a Seal of Approval for digital data to ensure that archived data can still be found, understood and used in the future. In 2009 this Data Seal of Approval (DSA was transferred to an international body, the DSA Board, which has managed and further developed the guidelines and the peer review process ever since.The objectives of the DSA are to safeguard data, ensure high quality and guide reliable management of data for the future without requiring implementation of new standards, regulations or heavy investments. The DSA contains 16 guidelines for applying and verifying quality aspects concerning the creation, storage, use and reuse of digital data.Based on feedback from data archives that applied for a DSA and different case studies we have gained some insight into the benefits of DSA. Still, the impact of having the Seal is not easy to measure. Seal holders usually refer to qualitative benefits in the form of increased awareness of the value of their repositories to their communities, funders and publishers.Ten years down the line we can safely state that the Data Seal of Approval has proven its added value. If we try to look five years into the future, what can we expect? There are different developments: a growing interest in DSA among European research infrastructures, the collaboration between DSA and the ISCU World Data System under the umbrella of the RDA (Research Data Alliance and the European Commission is showing a growing interest in certification services.The success of DSA also provides the challenge to further

  3. Ten years EULAR Scleroderma Research and Trials (EUSTAR): what has been achieved?

    Science.gov (United States)

    Müller-Ladner, Ulf; Tyndall, Alan; Czirjak, Laszlo; Denton, Christopher; Matucci-Cerinic, Marco

    2014-02-01

    Ten years ago a group of researchers interested in and dedicated to the field of systemic sclerosis started a unique experiment called European League Against Rheumatism (EULAR) Scleroderma Trials And Research (EUSTAR) that was designed to establish a large-scale database in a rare disease to facilitate the exact characterisation of this debilitating disease, spread the knowledge even beyond the borders of Europe and stimulate innovative research targeting the major problems of the affected patients. This EUSTAR experiment, with all its facets, including the creation of a large-scale database, the initiation of more than 40 investigator-driven clinical and basic science projects, the teaching of more than 400 young clinicians in the field of systemic sclerosis and the realisation of multicenter EU grants, which were all facilitated by an initial research grant from EULAR, is outlined and commented upon by the members of the steering committee in this viewpoint article on behalf of the now more than 150 contributing centres and the international systemic sclerosis patients' association, the Federation of European Scleroderma Associations.

  4. [Thinking about academic development of acupuncture and moxibustion in recent ten years].

    Science.gov (United States)

    Wen, Bi-ling; Jia, Chun-sheng; Liu, Wei-hong; Yang, Yong-qing; Wang, Ling-ling; Yang, Hua-yuan; Wu, Xiao-dong; Shen, Xue-yong; Xu, Ping; Zhao, Jing-shen; Liu, Jun-ling; Cheng, Kai; Zhu, Wen-zeng

    2009-12-01

    Through combing the academic development of acupuncture in recent ten years, objectively reflects the real development status of acupuncture subject on these aspects sucl as basis, clinic, equipment, teaching and standardization, etc., shows the scientific and technological achievements and the highlights of the acupuncture academic development, analyzes the bottleneck and dilemma of the acupuncture academic development. It is indicated that there are several problems existed in acupuncture researche at present, such as the scale and the input of the acupuncture theory research are not enough, the basic research and clinical application is disjointed, the correlation between the acupoints and viscera need more systematic and further researches, the design level of clinical research on acupoints' main indications should be improved. From now on we should follow the inherent rule of the traditional theory of Chinese medicine and the way of integrated thinking, explore the new rule of acupuncture academic development, in order to fit the new historical period, and comprehensively promote the sustainable and coordinated development of acupuncture science.

  5. Reverse shoulder arthroplasty in young patient with achondroplasia - Ten year follow up: Case report.

    Science.gov (United States)

    van den Broek, M; Verborgt, O; Declercq, G

    2017-08-05

    Skeletal dysplasia in achondroplasia can affect all body joints - including the glenohumeral joint - and is prone to develop to degenerative osteoarthritis (OA). This may cause pain and mobility problems at young age. Surgical treatment is challenging due to the dysplastic anatomy of the shoulder joint - with a dysplastic deformed short humerus, a small, hypoplastic medialized glenoid and lateralized acromion - and the long life expectancy of these patients. The indications for reverse shoulder arthroplasty (RSA) evolved during years with rotator cuff tears and rotator cuff arthropathy in combination with or without glenohumeral OA as the main indicator, with good short to mid-term results. Long term results of RSA are rarely found in literature, especially in young patients. The use of a RSA in glenohumeral OA with an intact rotator cuff has rarely been reported. In this case report we present the ten-year clinical and radiographic results of a RSA for the treatment of degenerative OA with glenohumeral dysplasia in a young patient with achondroplasia. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  6. Ten years of publicly funded biological disease-modifying antirheumatic drugs in Australia.

    Science.gov (United States)

    Hopkins, Ashley M; Proudman, Susanna M; Vitry, Agnes I; Sorich, Michael J; Cleland, Leslie G; Wiese, Michael D

    2016-02-01

    Biological disease-modifying antirheumatic drugs (bDMARDs) for rheumatoid arthritis (RA) treatment were among the first high-cost medicines to be subsidised in Australia. High-cost medicines pose several challenges to the Australian National Medicines Policy, which aims to provide timely access to effective medicines at a cost individuals and the community can afford. Thus, novel restriction criteria were developed to encourage cost-effective use of bDMARDs. Government expenditure on bDMARD subsidies for RA treatment grew to about $383 million in 2014. Evidence that initiation and continuation criteria for bDMARDs meet usually applied cost-benefit criteria is lacking. The combined expenditure on tocilizumab, certolizumab pegol and golimumab (added to the Australian Government's Pharmaceutical Benefits Scheme in 2010) was $93 million in 2014, which is 210% over the initial estimate. Present and future challenges with regard to bDMARDs for RA and other high-cost drugs include improved expenditure predictions, monitoring of cost-effectiveness in relation to actual use and strategic development, regulation and use of biosimilars. Ten years of documentation on clinical and laboratory findings indicating eligibility to initiate and continue on bDMARDs remains un-used. These data represent an untapped opportunity to promote quality of use of bDMARDs and biosimilars and to improve cost predictions for high-cost drugs.

  7. [Smoking among psychology students over a ten-year period (1996-2006)].

    Science.gov (United States)

    Míguez Varela, María del Carmen; Becoña Iglesias, Elisardo

    2009-11-01

    The purpose of this study was to analyze the evolution of smoking among Psychology students at the University of Santiago de Compostela (Spain) over a ten-year period (1986-2006). We also assessed the extent of knowledge of the Spanish health legislation on tobacco (Ley 28/2005) and its effect on smoking. We administered a questionnaire to representative samples of students from the 1st year of their Psychology course to the 5th year, on four occasions. In the academic year 1996-1997 (N = 835), 34% of the sample claimed to be daily smokers; in 1999-2000 (N = 842), the figure was 35.2%; in 2003-2004 (N = 835) it was 31.9%; and in 2006-2007 (N = 688), it was 22.8%. Moreover, in the last assessment, 97.1% of the sample reported being aware of the legislation (Ley 28/2005) and 41.9% of the smokers claimed that it had some degree of influence on their smoking. It can be stated that, although overall current prevalence of smoking is similar to that of 10 years ago, a significant change is observed in the profile of smokers. This change is expressed in lower levels of nicotine dependence and a decrease in the percentage of daily smokers, together with an increase in occasional smokers.

  8. Analyzing the Study of Using Acupuncture in Delivery in the Past Ten Years in China

    Directory of Open Access Journals (Sweden)

    Yingru Chen

    2014-01-01

    Full Text Available The use of acupuncture in inducing delivery has a long history in China. With progress over time, it has been applied in many aspects. For further study of acupuncture in delivery, this paper analyzed the papers using acupuncture in delivery in the past ten years in mainland China. 87 literatures were picked out by searching relevant electronic databases and bibliographies of relevant journals. The analysis showed randomized controlled trials that were the major type of research, while preclinical researches and literature reviews only account for around ten percent, respectively. Clinical researches indicated that acupuncture can relieve labor pain, promote maternal uterine contraction, shorten birth process, and treat postpartum disorders. Preclinical researches found that acupuncture can adjust certain hormones and improve uterus contraction of late-stage pregnant rats. However, due to lack of large multicenter randomized controlled clinical trials, standardized evaluations of clinical effects in clinical researches and detailed mechanism study in preclinical researches and unequivocal conclusions about the effectiveness, efficacy, and mechanisms of acupuncture in this field cannot be obtained from those researches yet. Further clinical and preclinical studies about the use of acupuncture in delivery with improved methodology is still needed.

  9. Ten-year operational dust forecasting - Recent model development and future plans

    Energy Technology Data Exchange (ETDEWEB)

    Kallos, G; Spyrou, C; Astitha, M; Mitsakou, C; Solomos, S; Kushta, J; Pytharoulis, I; Katsafados, P; Mavromatidis, E; Papantoniou, N; Vlastou, G [University of Athens, School of Physics, Atmospheric Modeling and Weather Forecasting Group - UOA/AM and WFG, University Campus, Bldg. PHYS-V, Athens 15784 (Greece)], E-mail: kallos@mg.uoa.gr

    2009-03-01

    The Sahara desert is one of the major sources of mineral dust on Earth, producing up to 2x10{sup 8} t yr-{sup 1}. A combined effort has been devoted during the last ten years at the University of Athens (UOA) from the Atmospheric Modeling and Weather Forecasting Group (AM and WFG) to the development of an analysis and forecasting tool that will provide early warning of Saharan dust outbreaks. The developed tool is the SKIRON limited-area forecasting system, based on the Eta limited area modeling system with embedded algorithms describing the dust cycle. A new version of the model is currently available, with extra features like eight-size particle bins, radiative transfer corrections, new dust source identification and utilization of rocky soil characterization and incorporation of more accurate deposition schemes. The new version of SKIRON modeling system is coupled with the photochemical model CAMx in order to study processes like the shading effect of dust particles on photochemical processes and the production of second and third generation of aerosols. Moreover, another new development in the AM and WFG is based on the RAMS model, with the incorporation of processes like dust and sea-salt production, gas and aqueous phase chemistry and particle formation. In this study, the major characteristics of the developed (and under development) modeling systems are presented, as well as the spatiotemporal distribution of the transported dust amounts, the interaction with anthropogenically-produced particles and the potential implications on radiative transfer.

  10. Over ten years after the implementation of the Teacher's Law: watching and expecting

    Institute of Scientific and Technical Information of China (English)

    Yin Li

    2006-01-01

    It has been over ten years since the Teacher's Law took effect on January 1,1994,and its promulgation and implementation have somewhat helped in protecting teachers' legal rights and interests.Undeniably,however,the Teacher's Law is defective in many aspects,such as the absence of teachers' legal identity,its failure to safeguard a teacher's essential interests and rights,serious laggardness of the teacher's appointment system and obstacles to dealing with teachers' complaints and litigations.All such defectiveness make the legislative purpose"to safeguard the teacher's legal rights and interests"in Article 1 of the Teacher's Law less effective in practice.Therefore,in order to judicially assist teachers in safeguarding their own legal rights and interests,it is necessary to modify the Teacher's Law and especially give priorities to:(1) defining the identity of the state staff member for teachers;(2)treating teachers owed to in arrears as peasant-workers,and paying and remunerating them punctually(3)formulating detailed measures on the implementation of the teacher's appointment system as soon as possible,solving problems of unemployment of teachers arising from the inequality between the teacher's rights,the school's power and the absence of the teacher's identity;(4)establishing a lawsuit system connected with teachers' complaints and personnel arbitration.

  11. Ten years of photonics education at the college level in Ontario: results and by-products

    Science.gov (United States)

    Nantel, Marc

    2010-08-01

    In 2000, there was no way for an Ontario student to obtain a credential in optics, laser or photonics without going through graduate school. This was in, arguably, the world-leading jurisdiction in photonics-enabled telecommunications industry. To alleviate this problem and supply the job market with highly-qualified people in the field of optics and photonics, the Ontario Centres of Excellence - then as Photonics Research Ontario - partnered with Algonquin College (Ottawa) and Niagara College (Welland) to establish over the past decade a suite of programs: a 1-year Certificate in Advanced Lasers, a 2-year Diploma for Photonics Engineering Technician, a 3-year Diploma for Photonics Engineering Technologists and a 4-year Bachelor of Applied Technology - Photonics. Much has been learnt along the way - the crucial need for industrial partner and government support, for example - and many course corrections had to be made (telecom bust, anyone?). The author will share the results of this 10-year journey so far, the lessons learnt, and a view to the next ten years for these programs and photonics education in Ontario in general.

  12. Modeling the Office of Science ten year facilities plan: The PERI Architecture Tiger Team

    Science.gov (United States)

    de Supinski, Bronis R.; Alam, Sadaf; Bailey, David H.; Carrington, Laura; Daley, Chris; Dubey, Anshu; Gamblin, Todd; Gunter, Dan; Hovland, Paul D.; Jagode, Heike; Karavanic, Karen; Marin, Gabriel; Mellor-Crummey, John; Moore, Shirley; Norris, Boyana; Oliker, Leonid; Olschanowsky, Catherine; Roth, Philip C.; Schulz, Martin; Shende, Sameer; Snavely, Allan; Spear, Wyatt; Tikir, Mustafa; Vetter, Jeff; Worley, Pat; Wright, Nicholas

    2009-07-01

    The Performance Engineering Institute (PERI) originally proposed a tiger team activity as a mechanism to target significant effort optimizing key Office of Science applications, a model that was successfully realized with the assistance of two JOULE metric teams. However, the Office of Science requested a new focus beginning in 2008: assistance in forming its ten year facilities plan. To meet this request, PERI formed the Architecture Tiger Team, which is modeling the performance of key science applications on future architectures, with S3D, FLASH and GTC chosen as the first application targets. In this activity, we have measured the performance of these applications on current systems in order to understand their baseline performance and to ensure that our modeling activity focuses on the right versions and inputs of the applications. We have applied a variety of modeling techniques to anticipate the performance of these applications on a range of anticipated systems. While our initial findings predict that Office of Science applications will continue to perform well on future machines from major hardware vendors, we have also encountered several areas in which we must extend our modeling techniques in order to fulfill our mission accurately and completely. In addition, we anticipate that models of a wider range of applications will reveal critical differences between expected future systems, thus providing guidance for future Office of Science procurement decisions, and will enable DOE applications to exploit machines in future facilities fully.

  13. Modeling the Office of Science Ten Year Facilities Plan: The PERI Architecture Tiger Team

    Energy Technology Data Exchange (ETDEWEB)

    de Supinski, Bronis R.; Alam, Sadaf; Bailey, David H.; Carrington, Laura; Daley, Chris; Dubey, Anshu; Gamblin, Todd; Gunter, Dan; Hovland, Paul D.; Jagode, Heike; Karavanic, Karen; Marin, Gabriel; Mellor-Crummey, John; Moore, Shirley; Norris, Boyana; Oliker, Leonid; Olschanowsky, Catherine; Roth, Philip C.; Schulz, Martin; Shende, Sameer; Snavely, Allan; Spear, Wyatt; Tikir, Mustafa; Vetter, Jeff; Worley, Pat; Wright, Nicholas

    2009-06-26

    The Performance Engineering Institute (PERI) originally proposed a tiger team activity as a mechanism to target significant effort optimizing key Office of Science applications, a model that was successfully realized with the assistance of two JOULE metric teams. However, the Office of Science requested a new focus beginning in 2008: assistance in forming its ten year facilities plan. To meet this request, PERI formed the Architecture Tiger Team, which is modeling the performance of key science applications on future architectures, with S3D, FLASH and GTC chosen as the first application targets. In this activity, we have measured the performance of these applications on current systems in order to understand their baseline performance and to ensure that our modeling activity focuses on the right versions and inputs of the applications. We have applied a variety of modeling techniques to anticipate the performance of these applications on a range of anticipated systems. While our initial findings predict that Office of Science applications will continue to perform well on future machines from major hardware vendors, we have also encountered several areas in which we must extend our modeling techniques in order to fulfill our mission accurately and completely. In addition, we anticipate that models of a wider range of applications will reveal critical differences between expected future systems, thus providing guidance for future Office of Science procurement decisions, and will enable DOE applications to exploit machines in future facilities fully.

  14. Modeling the Office of Science Ten Year Facilities Plan: The PERI Architecture Team

    Energy Technology Data Exchange (ETDEWEB)

    de Supinski, Bronis R. [Lawrence Livermore National Laboratory (LLNL); Alam, Sadaf R [ORNL; Bailey, David [Lawrence Berkeley National Laboratory (LBNL); Carrington, Laura [University of California, San Diego; Daley, Christopher [University of Chicago; Dubey, Anshu [University of Chicago; Gamblin, Todd [Lawrence Livermore National Laboratory (LLNL); Gunter, Dan [Lawrence Berkeley National Laboratory (LBNL); Hovland, Paul [Argonne National Laboratory (ANL); Jagode, Heike [ORNL; Karavanic, Karen [Portland State University; Marin, Gabriel [ORNL; Mellor-Crummey, John [Rice University; Moore, Shirley [University of Tennessee, Knoxville (UTK); Norris, Boyana [Argonne National Laboratory (ANL); Oliker, Leonid [Lawrence Berkeley National Laboratory (LBNL); Olschanowsky, Cathy [San Diego Supercomputer Center; Roth, Philip C [ORNL; Schulz, Martin [Lawrence Livermore National Laboratory (LLNL); Shende, Sameer [University of Oregon; Snavely, Allan [University of California, San Diego; Spea, Wyatt [University of Oregon; Tikir, Mustafa [San Diego Supercomputer Center; Vetter, Jeffrey S [ORNL; Worley, Patrick H [ORNL; Wright, Nicholas [San Diego Supercomputer Center

    2009-01-01

    The Performance Engineering Institute (PERI) originally proposed a tiger team activity as a mechanism to target significant effort optimizing key Office of Science applications, a model that was successfully realized with the assistance of two JOULE metric teams. However, the Office of Science requested a new focus beginning in 2008: assistance in forming its ten year facilities plan. To meet this request, PERI formed the Architecture Tiger Team, which is modeling the performance of key science applications on future architectures, with S3D, FLASH and GTC chosen as the first application targets. In this activity, we have measured the performance of these applications on current systems in order to understand their baseline performance and to ensure that our modeling activity focuses on the right versions and inputs of the applications. We have applied a variety of modeling techniques to anticipate the performance of these applications on a range of anticipated systems. While our initial findings predict that Office of Science applications will continue to perform well on future machines from major hardware vendors, we have also encountered several areas in which we must extend our modeling techniques in order to fulfilll our mission accurately and completely. In addition, we anticipate that models of a wider range of applications will reveal critical differences between expected future systems, thus providing guidance for future Office of Science procurement decisions, and will enable DOE applications to exploit machines in future facilities fully.

  15. Green Tea as an Agricultural Based Health Promoting Food: The Past Five to Ten Years

    Directory of Open Access Journals (Sweden)

    Qin-Yin Shi

    2012-12-01

    Full Text Available The consumption of tea originated in ancient China over 4000 years ago and is currently the second most popular beverage in the world after water. Tea is an aromatic beverage prepared by pouring hot water over cured leaves of the Camellia sinensis plant. The link between tea intake, most notably green tea, and health has resulted in intense research on the components responsible for preventing the onset of several chronic diseases, including atherosclerosis, cancer, obesity and diabetes. In particular, the high levels of chemically diverse phenols (e.g., phenolic acids, flavonoids present in tea exhibit potent protective properties against many of these diseases. Although health related research on green tea and its predominant phenol (catechins has been on-going for decades, major advances have occurred in the last 5–10 years. Therefore, this review focuses on seminal studies reported primarily within the last five years but not extending past ten years on the link between health and green tea with an emphasis on the catechins.

  16. Hong Kong Students’ Levels of Political Trust Ten Years after the Return to Chinese Sovereignty

    Directory of Open Access Journals (Sweden)

    Kerry John Kennedy

    2012-04-01

    Full Text Available Hong Kong’s return to the People’s Republic of China in 1997 marked the beginning of a political transition that, if successful, will result in full democracy by 2020 (Ma 2008. Given that there are different levels of political trust in established and emerging democracies (Catterberg, Moreno 2005 and that regime changes itself exerts an influence on trust, this paper reports on a study that compares levels of political trust between two samples of Hong Kong’s young people. The results indicated that more than ten years after Hong Kong’s retrocession to China, some institutions were more strongly endorsed in 2009 than in 1999 but others registered a lower level of endorsement. Structurally it seems that ‘political trust’ is understood by both samples as a multidimensional construct that has a direct impact on the way they see their future citizenship responsibilities The implications of these results for both political theory and civic education are discussed.

  17. Naive (commonsense) geography and geobrowser usability after ten years of Google Earth

    Science.gov (United States)

    Hamerlinck, J. D.

    2016-04-01

    In 1995, the concept of ‘naive geography’ was formally introduced as an area of cognitive geographic information science representing ‘the body of knowledge that people have about the surrounding geographic world’ and reflecting ‘the way people think and reason about geographic space and time, both consciously and subconsciously’. The need to incorporate such commonsense knowledge and reasoning into design of geospatial technologies was identified but faced challenges in formalizing these relationships and processes in software implementation. Ten years later, the Google Earth geobrowser was released, marking the beginning of a new era of open access to, and application of, geographic data and information in society. Fast-forward to today, and the opportunity presents itself to take stock of twenty years of naive geography and a decade of the ubiquitous virtual globe. This paper introduces an ongoing research effort to explore the integration of naive (or commonsense) geography concepts in the Google Earth geobrowser virtual globe and their possible impact on Google Earth's usability, utility, and usefulness. A multi-phase methodology is described, combining usability reviews and usability testing with use-case scenarios involving the U.S.-Canadian Yellowstone to Yukon Initiative. Initial progress on a usability review combining cognitive walkthroughs and heuristics evaluation is presented.

  18. Ten years after "Worrying trends in econophysics": developments and current challenges

    Science.gov (United States)

    Ormerod, Paul

    2016-12-01

    Econophysics has made a number of important additions to scientific knowledge. Yet it continues to lack influence with both economists and policy makers. Ten years ago, I and three other economists sympathetic to econophysics wrote a paper on worrying trends within the discipline. For example, its lack of awareness of the economics literature, and shortfalls in the use of statistical analysis. These continue to be obstacles to wider acceptance by economists. Like all agents, policy makers respond to incentives, and economists understand this very well. Much of the econophysics community appears to think that simply doing good science is sufficient to have the work recognised, rather than relating to the motivations and incentives of policy makers. Nevertheless, econophysics now has three major opportunities to advance knowledge in areas where policy makers perceive weaknesses in what they are presented with by economists. All can benefit from the analysis of Big Data. The first is a core model of agent behaviour which is more relevant to cyber society than the rational agent model of economics. Second, extending our understanding of the business cycle, primarily by incorporating the importance of networks into models. Third, devising proper measures of output in cyber society.

  19. The origin of the future ten questions for the next ten years

    CERN Document Server

    Gribbin, John

    2006-01-01

    How did the universe begin? Where do galaxies come from? How do stars and planets form? Where do the material particles we are made of come from? How did life begin? Today we have only provisional answers to such questions. But scientific progress will improve these answers dramatically over the next ten years, predicts John Gribbin in this riveting book. He focuses on what we know—or think we know—about ten controversial, unanswered issues in the physical sciences and explains how current cutting-edge research may yield solutions in the very near future. With his trademark facility for engaging readers with or without a scientific background, the author explores ideas concerning the creation of the universe, the possibility of other forms of life, and the fate of the expanding cosmos. He examines “theories of everything,” including grand unified theories and string theory, and he discusses the Big Bang theory, the origin of structure and patterns of matter in the galaxies, and dark mass and dark ene...

  20. Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup

    Directory of Open Access Journals (Sweden)

    Ze Rui Wu

    2016-01-01

    Full Text Available Objective. The aim of this study is to observe clinical outcomes after more than ten years of followup in a group of patients with invasive giant prolactinomas (IGPs treated with dopamine agonists (DAs. Methods. Twenty-five patients met the criteria of IGPs, among which 16 patients primarily received bromocriptine (BRC and the other nine had undergone unsuccessful microsurgery prior to BRC treatment. Results. After a mean follow-up period of 135.5±4.7 months, the clinical symptoms in all patients improved by different degrees. Tumor volume was decreased by a mean of 98.6%, and the tumors of 19 patients had almost completely disappeared. The mean duration of treatment at maximal doses of BRC was 48.5 months. At the last follow-up visit, nineteen patients had normal PRL levels, and 14 of these patients had received the low-dose BRC treatment (at an average of 2.9±0.3 mg/d. Younger patients < 25 years had a significantly higher rate of persistent hyperprolactinemia after long-term BRC treatment (p=0.043. Conclusion. DAs are a first-line therapy for IGPs because they can effectively achieve long-term control in both shrinking tumor volume and normalizing the PRL level, and majority of patients need low-dose DA maintenance. Younger patients are prone to persistent hyperprolactinemia despite long-term DA treatment.

  1. Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup

    Science.gov (United States)

    Wu, Ze Rui; Zhang, Yong; Lin, Shao Jian; Su, Zhi Peng; Wei, Yong Xu; Shang, Han Bing; Yang, Wen Lei; Zhao, Wei Guo

    2016-01-01

    Objective. The aim of this study is to observe clinical outcomes after more than ten years of followup in a group of patients with invasive giant prolactinomas (IGPs) treated with dopamine agonists (DAs). Methods. Twenty-five patients met the criteria of IGPs, among which 16 patients primarily received bromocriptine (BRC) and the other nine had undergone unsuccessful microsurgery prior to BRC treatment. Results. After a mean follow-up period of 135.5 ± 4.7 months, the clinical symptoms in all patients improved by different degrees. Tumor volume was decreased by a mean of 98.6%, and the tumors of 19 patients had almost completely disappeared. The mean duration of treatment at maximal doses of BRC was 48.5 months. At the last follow-up visit, nineteen patients had normal PRL levels, and 14 of these patients had received the low-dose BRC treatment (at an average of 2.9 ± 0.3 mg/d). Younger patients < 25 years had a significantly higher rate of persistent hyperprolactinemia after long-term BRC treatment (p = 0.043). Conclusion. DAs are a first-line therapy for IGPs because they can effectively achieve long-term control in both shrinking tumor volume and normalizing the PRL level, and majority of patients need low-dose DA maintenance. Younger patients are prone to persistent hyperprolactinemia despite long-term DA treatment. PMID:27999593

  2. China and Outsourcing Offshore in the 21st Century:the Next Ten Years

    Institute of Scientific and Technical Information of China (English)

    Joseph; F.Greco

    2011-01-01

    <正>In light of the current global economic slowdown and the concentrated efforts of the Chinese government to invest in the outsourcing industry,this study focuses on two critical issues for future growth over the next ten years:the fragmentation of the Chinese outsourcing industry and the shortage of business personnel with international business skills.After a literature review that,for the first time,integrates the Chinese studies with global research,we summarize the current state of out-sourcing offshore and the potential in the Chinese economy.We then analyze the out-sourcing industry using a general equilibrium model requiring partner search with service providers by final producers from East and West,focusing on two key variables directly related to the issue of Chinese industrial fragmentation:the service provider location and final producer search function.We then draw implications related to China’s future outsourcing efforts and policy changes that address the issue of industrial fragmentation.

  3. Ten Years of China's Accession to the WTO and Changes of Global Multilateral Trading System%Ten Years of China's Accession to the WTO and Changes of Global Multilateral Trading System

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    China's accession to the World Trade Organization has been for ten years. This paper reviews the reform and development after China's accession to the World Trade Organization. In the past ten years, China has contributed to global multilateral trade system in many ways, such as promoting the development of international trade, opposing trade protectionism, faithfully carrying out multilateral trade rules, coordinating multilateral trade negotiations, actively participating in multilateral trading system construction as well as effectively safeguarding the interests of developing countries. For ten years, multilateral trading system has changed mainly in force structure, topic structure and external transparency. Looking into the future, multilateral trade system reform should focus on system construction and opposition to trade protectionism. Finally, based on practice experience in WTO these years, this paper reaches several enlightenments of China's participating in global economic management.

  4. 1994-2004 : Ten years of European effort for education in Seismology

    Science.gov (United States)

    Virieux, J.; Zollo, A.; Lomax, A.; Berenguer, J.; Laj, C.; Bobbio, A.

    2004-12-01

    Following trends of the pioneer PEPP project in USA, an European group has investigated since 1994 how to promote physics and earth sciences and, more specifically, how to educate scientifically and socially young generations to environmental hazards. Seismology has been selected as the vehicle for a prototypical ten-years experience of teaching and learning sciences in European high schools accounting for the specificity and differencies of educational systems in each country. This general purpose has required competences and strong interactions of both teachers, researchers and high school students. Over ten years of continuous activities, these people have found that the target was very ambitious and that both high-tech efforts as well as very focused teaching procedures must be set on. Dedicated instruments were developped in two years through interactions between researchers,teachers and students in order to fit both the scientific quality but also pedagogical features and were installed in different parts of Europe. The sequence of Colfiorito Earthquakes in September-October 1997 was the first data collected simultaneously in different European schools. Since then, more thant 50 stations have been deployed over Europe and data have been made available for education purposes. Data from these seismic stations have been used as the back-bone for interactions between students/pupils, teachers and researchers leading to the development of dedicated teaching and learning materials as software tools for data analysis, simple experimentations and so on. The framework for such an European initiative has been provided by Italian and French national funds and put together under the banner of the so-called EDUSEIS projet. This EDUcational SEISmological European Network (http://www.eduseis.org/) has shown that indeed environmental education is possible with its typical feature of long-term efforts. Funding through Europe will certainly increase the cohesion of this

  5. Ten-year results of physical activity after high tibial osteotomy in patients with knee osteoarthritis.

    Science.gov (United States)

    W-Dahl, Annette; Toksvig-Larsen, Sören; Lindstrand, Anders

    2017-03-01

    The purpose was to describe physical activity with respect to leisure and working activity in patients operated on by high tibial osteotomy using the hemicallotasis technique for knee osteoarthritis (OA), preoperatively and 10 years postoperatively. Seventy-nine patients, median age 55 (range 35-66), operated on by high tibial osteotomy using the hemicallotasis technique for knee OA 2001-2003 were included. Questionnaires for evaluation of physical and working activity, satisfaction as well as the Knee injury and Osteoarthritis Outcome Score (KOOS) were filled in preoperatively and 2 and 10 years postoperatively. Conversion to knee arthroplasty was obtained through the Swedish Knee Arthroplasty Register. Changes between two postoperative measurements were assessed by Wilcoxon's rank test. Twenty-five patients were converted to a total knee arthroplasty, and nine patients were lost to follow-up during the 10 years, resulted in 45 patients available for follow-up. Preoperatively, 33/45 patients were physically active mainly in heavy yard/household work, and 43/45 patients were working active. Ten years after the HCO, 23/45 patients were still active with golf, dancing, hiking, etc., and 23/45 were retired. At 10 years postoperatively compared to 2 years postoperatively, the patients experienced more problems with pain (89 compared to 69, p = <0.0001). Of 45 patients, 36 were satisfied with the high tibial osteotomy surgery in general 10 years postoperatively, while 13/45 were satisfied with their sport and recreational function. The 10-year results indicate that high tibial osteotomy using the hemicallotasis technique for knee OA is an option for selected patients that improves the level of physical activity, with mild deterioration over time, and gives the majority of the patients the possibility to be working active until retirement. Level IV.

  6. Clinical characteristics of renal cancer in Malaysia : a ten year review.

    Science.gov (United States)

    Singam, Praveen; Ho, Christopher; Hong, Goh Eng; Mohd, Azrif; Tamil, Azmi Md; Cheok, Lee Boon; Zainuddin, Zulkifli

    2010-01-01

    Renal cancer is rare and its incidence is 1.9 per 100,000 in the Malaysian population, which consists of three major ethnic groups (Malay, Chinese and Indians). A retrospective study was her conducted to identify clinical characteristics and ethnic background influences on presentation. The study included all renal cancer patients from a single medical institution over ten years, with a total of 75 cases. Seventy-three patients underwent surgery while 2 received only radiotherapy or chemotherapy. The male to female ratio was 2.75:1. Incidence was equal among the Malay (49.3%) and Chinese ethnic groups (45.3%). Mean age of patients were 57.1 (18-93) years old. There were 26 (37.4%) patients with Stage I disease, 14 (18.7%) at Stage II, 23 (30.7%) at Stage III and 12 (16%) at Stage IV. The Chinese race presented at mean older age (p= 0.02) and later stage of disease (p= 0.046). Patients above 40 years old had more advanced stage disease (p= 0.023). Tumour histology were clear cell (72%), urothelial cell (13.3%), sarcomatoid cell and nephroblastoma each contributed 2.7%. The mean tumour size was 8.1 (2-20) cm. There was substantial agreement between the pre and post operative staging (kappa 0.691). In conclusion we observed significant influences of age and race in the clinical presentation of renal cancer in our institution based population. There was larger male to female ratio and mean tumour size as compared to previous epidemiology studies.

  7. Epidemiology, management and survival outcomes of primary cutaneous melanoma: a ten-year overview.

    Science.gov (United States)

    Aubuchon, M M F; Bolt, L J J; Janssen-Heijnen, M L G; Verleisdonk-Bolhaar, S T H P; van Marion, A; van Berlo, C L H

    2017-02-01

    Malignant melanoma (MM) is the most aggressive type of skin cancer, accounting for 90% of all the skin cancer mortality. The objective of this study was providing an overview of current patient- and tumour characteristics, treatment strategies, complications and survival in patients with MM over the past ten years. Hereby, an up-to-date view of every day clinical practice is obtained. Files of patients treated for primary cutaneous melanoma (n = 686) in the VieCuri Medical Centre in the Netherlands between January 2002 and December 2013 were retrospectively reviewed. Relevant patient features, tumour characteristics, and (surgical) outcomes were evaluated. The majority of all the patients presented thin tumours (59.1% stage 1A/in situ melanoma). Men showed more ulceration (17.7% vs. 8.4%, p < .01) and a significantly higher Breslow thickness than women (1.2 mm vs. 0.9 mm, p < .01). 14.6% (40/273) underwent sentinel lymph node biopsy (SLNB); 10/40 (25%) showed nodal metastasis, 50 patients (7.3%) developed distant metastases (M: 10.6%, F: 5%, p < .01). One-, 5- and 10- year disease specific survival rates were 96%, 86% and 84%, respectively. Median survival for stage 4 MM was 3 months. Extensive surgery was uncommon (n = 3). Patients generally presented with thin melanomas. Lymph node disease and distant metastases remained infrequently observed during following years, and general 1- and 5-year overall disease-specific survival rates exceeded 85%. Small numbers of rescue surgery and palliative medical treatment warrant further centralisation and investigation.

  8. Our results in surgical treatment of laryngotracheal stenosis, ten years experience

    Directory of Open Access Journals (Sweden)

    Jović Rajko M.

    2006-01-01

    Full Text Available Introduction. There are numerous techniques for the treatment of laryngotracheal stenosis. The aim of this paper was to present surgical techniques and results of treatment of laryngeal and laryngotracheal stenosis in a ten-year period by retrospective analysis. Material and methods. Medical records of 34 patients (17 male and 17 female surgically treated for laryngeal or laryngotracheal stenosis between 1995 and 2004 were analyzed. 19 (55.9% patients had previous surgical procedures, whereas fifteen patients (44.1 % were diagnosed and treated for the first time. Results. 5 patients had a glottic-subglottic stenosis, 11 patients had a subglottic stenosis, 16 patients had subglottic-tracheal stenosis and 2 patients had a glottic-subglottic-tracheal stenosis. 21 patients had normal vocal cord motion, 8 patients showed unilateral vocal cord fixation, and 5 had bilateral vocal cord fixation. Laryngotracheoplasty with anterior-posterior costal cartilage graft was performed in 24 patients, while single stage segmental laryngotracheal resection of the stenotic part was performed in 8 patients. One patient was operated in direct laryngomicroscopy and one with dilatation of the stenotic segment with T tube insertion. The most common complication was the development of granulation due to use of the Montgomery T-tube which was removed in direct laryngomicroscopy. Except for one patient, 33(97% patients were decannulated. There was no perioperative mortality. Conclusion. Although laiyngotracheoplasty with anterior-posterior costal cartilage graft placement cannot be used in all cases of laryngotracheal stenosis, it was the method of choice in previously operated patients with segmental resection of the stenotic segment. This method requires use of Montgomery T-tube or anesthesiological tube, which is very hard to keep clean. Better recovery, short hospitalization and excellent results were obtained with the cricotracheal segmental resection. .

  9. [Phenology of forest vegetation in northeast of China in ten years using remote sensing].

    Science.gov (United States)

    Hou, Xue-Hui; Niu, Zheng; Gao, Shuai

    2014-02-01

    Plant phenology is the best indicator of terrestrial ecosystem response to climate change and it becomes a hot issue in the study of global change. The forest in northeast of China plays an important part in global forest ecosystem. In this paper, yearly integrated Normalized Difference Vegetation Index (NDVI) of forest vegetation in northeast China was calculated based on Spot Vegetation datasets from 2001-2010, which has been filtered using Savtiky-Galoy method. And then, the yearly integrated NDVI profile was fitted using a logistic model. Two key parameters of forest phenology (start of season, SOS; end of season, EOS) were extracted according to the greatest rate of curvature of fitted cumulative NDVI and the length of forest phenology (length of season, LOS) was also analyzed. The main conclusions of this paper are (1) SOS mainly occurs in the 110th-140th day and EOS in 260th and 290th day. SOS displays a marked delayed from south to north while EOS gradually advances. However, the changes of SOS and EOS in ten years are not obvious. (2) Corresponding to the SOS and EOS, LOS of forest in study area mainly occurs in the 120th-160th day; however, it is spatially heterogeneous. LOS of forest in Greater Khingan Mountains is shorter (about 120-140 day) than forests in Xiao Hinggan Ling and Changbai Mountains (about 160 day). The results in this paper are concordant with records of phenology in situ measurements and previous researches in the same area. It indicates that forest phenophases using method in this paper from Spot Vegetation dataset is feasible.

  10. Radioinduced pulmonary fibrosis: prospective study of clinical, dosimetric and biological predictive factors after conformal irradiation of non at small cells bronchi carcinomas; Fibroses radiques pulmonaires: etude prospective des facteurs predictifs cliniques, dosimetriques et biologiques apres irradiation conformationnelle des carcinomes bronchiques non a petites cellules

    Energy Technology Data Exchange (ETDEWEB)

    Claude, L.; Ginestet, C.; Martel-Lafay, I.; Carrie, C. [Centre Leon-Berard, 69 - Lyon (France); Etienne-Mastroiani, B. [Hopital Louis-Pradel, 69 - Lyon (France); Arpin, D. [Hopital de la Croix-Rousse, 69 - Lyon (France); Vincent, M. [Hopital Saint-Luc-Saint-Joseph, 69 - Lyon (France); Falchero, L. [Hopital de Villefranche, 69 - Villefranche s/Saone (France); Blay, J.Y. [Hopital Edouard-Herriot, 69 - Lyon (France); Perol, D. [Centre Leon-Berard, 69 - Lyon (France)

    2007-11-15

    This broad prospective study confirms the contribution of dosimetry factors ( pulmonary average dose, V10 to V50) in the predictive part for the delayed radioinduced fibrosis. Contrary to the acute radioinduced pneumopathy, no significant relationship has been underlined between the variations of cytokines and the delayed radioinduced fibrosis risk. (N.C.)

  11. Cause-Specific Mortality in HIV-Positive Patients Who Survived Ten Years after Starting Antiretroviral Therapy

    DEFF Research Database (Denmark)

    Trickey, Adam; May, Margaret T; Vehreschild, Jorg-Janne

    2016-01-01

    years 656/13,011 (5%) patients died. Older age, male sex, injecting drug use transmission, AIDS, and low CD4 count and detectable viral replication ten years after starting combination antiretroviral therapy were associated with higher subsequent mortality. CD4 count at ART start did not predict......OBJECTIVES: To estimate mortality rates and prognostic factors in HIV-positive patients who started combination antiretroviral therapy between 1996-1999 and survived for more than ten years. METHODS: We used data from 18 European and North American HIV cohort studies contributing...... to the Antiretroviral Therapy Cohort Collaboration. We followed up patients from ten years after start of combination antiretroviral therapy. We estimated overall and cause-specific mortality rate ratios for age, sex, transmission through injection drug use, AIDS, CD4 count and HIV-1 RNA. RESULTS: During 50,593 person...

  12. A Cannulated Tri-Tapered Femoral Stem for Total Hip Arthroplasty: Clinical and Radiological Results at Ten Years.

    Science.gov (United States)

    Rajakulendran, Karthig; Strambi, Francesco; Ruggeri, Riccardo; Field, Richard E

    2015-10-01

    We report the ten-year clinical and radiological outcomes of a novel cannulated, tri-tapered femoral stem, used in primary total hip arthroplasty (110 stems in 98 patients). At ten years, two Tri-taper stems had been revised for infection and dislocation. The mean Oxford Hip Score improved from 13.46 pre-operatively, to 37.04. Radiological analysis revealed radiolucent lines in 57 cases, but none exceeded 2 mm thickness. Stem subsidence was identified in 63 cases, with mean distal tip migration of 3.8 mm. Survivorship with revision for aseptic loosening as the end point was 100% at 10 years. Stem survival with revision for any cause was 98.2% (95% CI, 92.9% to 99.5%). The ten-year results of the Tri-taper stem are comparable to other polished, tapered femoral stems. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. [Good agricultural practice (GAP) of Chinese materia medica (CMM) for ten years: achievements, problems and proposals].

    Science.gov (United States)

    Guo, Lan-Ping; Zhang, Yan; Zhu, Shou-Dong; Wang, Gui-Hua; Wang, Xiu; Zhang, Xiao-Bo; Chen, Mei-Lan; He, Ya-Li; Han, Bang-Xing; Chen, Nai-Fu; Huang, Lu-Qi

    2014-04-01

    This paper aims to summarize the achievements during the implementation process of good agricultural practice (GAP) in Chinese Materia Medica (CMM), and on basis of analyzing the existing problems of GAP, to propose further implementation of GAP in TCM growing. Since the launch of GAP in CMM growing ten years ago, it has acquired great achievements, including: (1) The promulgation of a series of measures for the administration of the GAP approval in the CMM growing; (2) The expanded planting area of CMM; (3) The increased awareness of standardized CMM growing among farmers and enterprises; (4) The establishment of GAP implementation bases for CMM growing; (5) The improvement of theory and methodology for CMM growing; (6) The development of a large group of experts and scholars in GAP approval for CMM production. The problems existing in the production include: (1) A deep understanding of GAP and its certification is still needed; (2) The distribution of the certification base is not reasonable; (3) The geo-economics effect and the backward farming practices are thought to be the bottlenecks in the standardization of CMM growing and the scale production of CMM; (4) Low comparative effectiveness limits the development of the GAP; (5) The base of breeding improved variety is blank; (6) The immature of the cultivation technique lead to the risk of production process; (7) The degradation of soil microbial and the continuous cropping obstacle restrict the sustainable development of the GAP base. To further promote the health and orderly GAP in the CMM growing, the authors propose: (1) To change the mode of production; (2) To establish a sound standard system so as to ensure quality products for fair prices; (3) To fully consider the geo-economic culture and vigorously promote the definite cultivating of traditional Chinese medicinal materials; (4) To strengthen the transformation and generalization of basic researches and achievements, in order to provide technical

  14. Creative Climate: A global ten-year communications, research and learning project about environmental change

    Science.gov (United States)

    Brandon, M. A.; Smith, J.

    2010-12-01

    The next ten years have been described by influential science and policy figures as ‘the most important in human history’. Many believe that the actions taken will decide whether we catastrophically change the atmosphere and eradicate our fellow species or find an alternative, less-damaging development path. But communications and public engagement initiatives have tended to focus on near term impacts or debates - whether they emphasise hazards, or trumpet ‘solutions’. There are signs of diminishing returns on communications and public engagement efforts, and serious obstacles to engaging around 40% of publics in e.g. the US and the UK. The Creative Climate web project takes a new approach, inviting people to see humanity’s intellectual and practical journey with these issues as an inspiring, dynamic and unfolding story. We are inviting people to join us in building a huge living archive of experiences and ideas that respond to these issues. The website will collect thoughts and stories from doorstep to workplace, from lab to garden; from international conference to community meeting - from all over the world. The body of diaries lie at the core of the project, but these are supplemented by the offer of free online learning resources and broadcast-quality audio and video materials. The project is experimental in terms of its scope, its approach to environmental communications and debate and in its use of media. It works with formal partners, including the BBC, yet also makes the most of the opportunities for user generated content to create a rich multimedia resource that can support research, learning and engagement. The design of the project is informed by environmental social science and communications research, and by an awareness of the unfolding potential of Internet based communications to support social change. It is also intended that the Creative Climate platform will develop so as to serve researchers by offering an open resource of qualitative

  15. Sexual orientation and relationship choice in borderline personality disorder over ten years of prospective follow-up.

    Science.gov (United States)

    Reich, D Bradford; Zanarini, Mary C

    2008-12-01

    The purpose of this study was to assess the prevalence of homosexuality/ bisexuality and same-sex relationships in a sample of 362 hospitalized subjects, 290 with borderline personality disorder (BPD) and 72 comparison subjects with other personality disorders. At baseline and at five contiguous 2-year follow-up intervals, subjects meeting DIB-R and DSM-III-R criteria for BPD or at least one other personality disorder were interviewed using a semi-structured interview about their sexual orientation and the gender of intimate partners. Subjects with BPD were significantly more likely than comparison subjects to report homosexual or bisexual orientation and intimate same-sex relationships. There were no significant differences between male and female borderline subjects in prevalence of reported homosexual or bisexual orientation or in prevalence of reported same-sex relationships. Subjects with BPD were significantly more likely than comparison subjects to report changing the gender of intimate partners, but not sexual orientation, at some point during the follow-up period. A reported family history of homosexual or bisexual orientation was a significant predictor of an aggregate outcome variable assessing homosexual/bisexual orientation and/or same sex relationship in borderline subjects. Results of this study suggest that same-gender attraction and/or intimate relationship choice may be an important interpersonal issue for approximately one-third of both men and women with BPD.

  16. Ten-Year Comparisons of Problems and Competencies for National Samples of Youth: Self, Parent, and Teacher Reports.

    Science.gov (United States)

    Achenbach, Thomas M.; Dumenci, Levent; Rescorla, Leslie A.

    2002-01-01

    This study compared national samples of United States' 11- to 18- year-olds assessed in 1989 and 1999. Parent, teacher and self-report sources showed small improvements in competencies and adaptive functioning and small declines in problems over ten years. No significant differences on any scales were found for youths assessed shortly before and…

  17. Ten years of sustainability evaluation using the MESMIS framework: Lessons learned from its application in 28 Latin American case studies

    NARCIS (Netherlands)

    Speelman, E.N.; López Ridaura, S.; Aliana-Colomer, N.; Astier, M.; Masera, O.

    2007-01-01

    This paper focuses on sustainability evaluation and, more specifically, it describes and analyses the Indicator-based Framework for Evaluation of Natural Resource Management Systems (MESMIS, its Spanish acronym), ten years after its development. This framework fulfilled a pioneering role by proposin

  18. Home Environment and School Performance: A Ten-Year Follow-up and Examination of Three Models of Environmental Action.

    Science.gov (United States)

    Bradley, Robert H.; And Others

    1988-01-01

    Examines home environments of children aged ten and eleven when they were six months and two years old. Significant correlations were observed between the home environments at two and ten years, children's achievement test scores, and classroom behavior. Home environment at six months was related to a minimal number of classroom behaviors. (RJC)

  19. Ten years after the unification : East Germany and the relevance of modern theories of trade, location and growth

    NARCIS (Netherlands)

    Brakman, S.; Schramm, M.; Garretsen, Harry

    2000-01-01

    In the paper we analyse, ten years after the German unification, the relevance of modern theoretical developments on trade, location and growth for East Germany using sectoral and regional data. Given our discussion of stylized facts about industry growth, economies of scale and differences in

  20. Organisation and Management of a Complete Bachelor Degree Offered Online at the University of Milan for Ten Years

    Science.gov (United States)

    Milani, Manuela; Papini, Sabrina; Scaccia, Daniela; Scarabottolo, Nello

    2014-01-01

    This paper is aimed at presenting some reflections on organisation and management of SSRI online: an e-learning initiative started at the University of Milan (Italy) in the academic year 2004/05 and offered to students over the last ten years. The initiative consisted in implementing the online version of an already existing three-year bachelor…

  1. 78 FR 71550 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado Second Ten-Year...

    Science.gov (United States)

    2013-11-29

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado Second Ten-Year PM 10 Maintenance Plan for Telluride AGENCY: Environmental Protection Agency...

  2. 78 FR 78797 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year...

    Science.gov (United States)

    2013-12-27

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year PM 10 Maintenance Plan for Pagosa Springs AGENCY: Environmental Protection Agency...

  3. 78 FR 46816 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year...

    Science.gov (United States)

    2013-08-02

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year Carbon Monoxide Maintenance Plan for Greeley AGENCY: Environmental Protection Agency...

  4. 78 FR 46861 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year...

    Science.gov (United States)

    2013-08-02

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year Carbon Monoxide Maintenance Plan for Greeley AGENCY: Environmental Protection Agency...

  5. 78 FR 57573 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado Second Ten-Year...

    Science.gov (United States)

    2013-09-19

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado Second Ten-Year PM 10 Maintenance Plan for Aspen AGENCY: Environmental Protection Agency (EPA)....

  6. 78 FR 41307 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year...

    Science.gov (United States)

    2013-07-10

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year PM 10 Maintenance Plan for Ca on City AGENCY: Environmental Protection Agency...

  7. 78 FR 56185 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year...

    Science.gov (United States)

    2013-09-12

    ... From the Federal Register Online via the Government Publishing Office ] ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year Carbon Monoxide Maintenance Plan for Fort Collins AGENCY: Environmental Protection...

  8. 78 FR 41342 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado Second Ten-Year...

    Science.gov (United States)

    2013-07-10

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado Second Ten-Year PM 10 Maintenance Plan for Ca on City AGENCY: Environmental Protection Agency...

  9. 78 FR 46552 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year...

    Science.gov (United States)

    2013-08-01

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year Carbon Monoxide Maintenance Plan for Colorado Springs AGENCY: Environmental...

  10. Early detection, early symptom progression and symptomatic remission after ten years in a first episode of psychosis study

    DEFF Research Database (Denmark)

    Simonsen, Erik; ten Velden Hegelstad, Wenche; Haahr, Ulrik Helt

    2013-01-01

    Background: Poor symptom outcome remains a challenge in psychosis: At least 50% of first-episode patients continue to have positive and/or negative symptoms after ten years. Objective: To investigate rates, early predictors and early symptom progression of long-term non-remitted psychosis in an e...

  11. Early detection, early symptom progression and symptomatic remission after ten years in a first episode of psychosis study.

    Science.gov (United States)

    Ten Velden Hegelstad, Wenche; Haahr, Ulrik; Larsen, Tor K; Auestad, Bjørn; Barder, Helene; Evensen, Julie; Joa, Inge; Johannessen, Jan O; Langeveld, Johannes; Melle, Ingrid; Opjordsmoen, Stein; Rossberg, Jan Ivar; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per; McGlashan, Thomas; Friis, Svein

    2013-02-01

    Poor symptom outcome remains a challenge in psychosis: At least 50% of first-episode patients continue to have positive and/or negative symptoms after ten years. To investigate rates, early predictors and early symptom progression of long-term non-remitted psychosis in an early detection study. Symptomatic remission according to new international criteria was assessed in 174 patients at ten-year follow-up. Remitted and non-remitted patients were compared on early symptom progression, and logistic regression was applied to predict non-remission. At ten years, 50% of patients were in symptomatic remission. Non-remission was predicted by positive symptoms at inclusion and during the first year of treatment. Of individual symptoms only hallucinations were significantly predictive of ten-year non-remission. Early symptom differences were not reflected by differences in treatment. Long-term symptomatic non-remission is associated with early positive symptoms. More assertive intervention may be needed in patients who do not respond robustly in the first year of treatment, whether or not they have been detected "early". Copyright © 2012 Elsevier B.V. All rights reserved.

  12. Ten years of health workforce planning in the Netherlands: a tentative evaluation of GP planning as an example.

    NARCIS (Netherlands)

    Greuningen, M. van; Batenburg, R.S.; Velden, L.F.J. van der

    2012-01-01

    INTRODUCTION: In many countries, health-care labour markets are constantly being challenged by an alternation of shortage and oversupply. Avoiding these cyclic variations is a major challenge. In the Netherlands, a workforce planning model has been used in health care for ten years. Case description

  13. Minimum ten-year follow-up of acetabular fracture fixation from the Irish tertiary referral centre.

    LENUS (Irish Health Repository)

    Magill, Paul

    2012-04-01

    Successful outcome from acetabular fracture fixation is multi-factorial. Long-term results are not frequently reported. Pooling such data from high output centres will help progress acetabular fixation. This paper presents the first ten-year data from the Irish tertiary referral centre.

  14. Cause-Specific Mortality in HIV-Positive Patients Who Survived Ten Years after Starting Antiretroviral Therapy

    Science.gov (United States)

    May, Margaret T.; Vehreschild, Janne; Obel, Niels; Gill, Michael John; Crane, Heidi; Boesecke, Christoph; Samji, Hasina; Grabar, Sophie; Cazanave, Charles; Cavassini, Matthias; Shepherd, Leah; d’Arminio Monforte, Antonella; Smit, Colette; Saag, Michael; Lampe, Fiona; Hernando, Vicky; Montero, Marta; Zangerle, Robert; Justice, Amy C.; Sterling, Timothy; Miro, Jose; Ingle, Suzanne; Sterne, Jonathan A. C.

    2016-01-01

    Objectives To estimate mortality rates and prognostic factors in HIV-positive patients who started combination antiretroviral therapy between 1996–1999 and survived for more than ten years. Methods We used data from 18 European and North American HIV cohort studies contributing to the Antiretroviral Therapy Cohort Collaboration. We followed up patients from ten years after start of combination antiretroviral therapy. We estimated overall and cause-specific mortality rate ratios for age, sex, transmission through injection drug use, AIDS, CD4 count and HIV-1 RNA. Results During 50,593 person years 656/13,011 (5%) patients died. Older age, male sex, injecting drug use transmission, AIDS, and low CD4 count and detectable viral replication ten years after starting combination antiretroviral therapy were associated with higher subsequent mortality. CD4 count at ART start did not predict mortality in models adjusted for patient characteristics ten years after start of antiretroviral therapy. The most frequent causes of death (among 340 classified) were non-AIDS cancer, AIDS, cardiovascular, and liver-related disease. Older age was strongly associated with cardiovascular mortality, injecting drug use transmission with non-AIDS infection and liver-related mortality, and low CD4 and detectable viral replication ten years after starting antiretroviral therapy with AIDS mortality. Five-year mortality risk was <5% in 60% of all patients, and in 30% of those aged over 60 years. Conclusions Viral replication, lower CD4 count, prior AIDS, and transmission via injecting drug use continue to predict higher all-cause and AIDS-related mortality in patients treated with combination antiretroviral therapy for over a decade. Deaths from AIDS and non-AIDS infection are less frequent than deaths from other non-AIDS causes. PMID:27525413

  15. Using a natural abilities battery for academic and career guidance: a ten-year study.

    Science.gov (United States)

    Brown, Corrie C; Harvey, Stephen B; Stiles, Dori

    2011-01-01

    Over a period of 10 years, first-year students from 11 consecutive veterinary classes conducted a self-assessment using a natural abilities survey. The present study analyzes the data compiled from students' self-assessment results. As a group, veterinary students are exceptional problem solvers, either through inductive or deductive reasoning, and have strong spatial relations capacities. Veterinary students have a range of learning styles with design memory being the primary vehicle for information delivery and tonal memory being the least frequently used style overall. Information gained on each student's natural abilities can be used to guide effective career decision making and enhance prospects for long-term career satisfaction.

  16. Patient preferences at ten years following initial diagnosis of atrial fibrillation: the Belgrade Atrial Fibrillation Study

    Directory of Open Access Journals (Sweden)

    Potpara TS

    2013-08-01

    Full Text Available Tatjana S Potpara,1,2 Marija M Polovina,2 Nebojsa M Mujovic,1,2 Aleksandar M Kocijancic,2 Gregory YH Lip3 1Faculty of Medicine, University of Belgrade, 2Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia; 3University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK Background: Many atrial fibrillation (AF patients have a poor understanding of the management of this condition. We investigated patient attitudes towards AF and a potential invasive treatment following an average 10-year period of prospective rhythm control in a cohort of newly diagnosed AF patients. Methods: This was a prospective registry-based study. At the regular annual visit in 2007, patients were asked at random to answer several AF-related questions. Results: Of 390 patients, 277 (71.0% reported symptom reduction over time, but only 45 (11.5% reported that they had "got used" to AF; 201 patients (51.5% stated they would always prefer sinus rhythm, and 280 (71.2% would accept an invasive AF treatment. Independent predictors for choosing an invasive procedure were younger age, impaired career/working capacity, and male gender (all P < 0.05. Conclusion: Our findings suggest that most AF patients prefer sinus rhythm and would readily accept an invasive procedure if it offered the possibility of a cure for their AF. Keywords: atrial fibrillation, catheter ablation, treatment, symptoms, patient preferences

  17. Ten-year literature review of global endometrial ablation with the NovaSure® device

    Directory of Open Access Journals (Sweden)

    Gimpelson RJ

    2014-03-01

    Full Text Available Richard J Gimpelson Mercy Clinic, Minimally Invasive Gynecology, Department of Obstetrics and Gynecology, Mercy Hospital St Louis, St Louis, MO, USA Abstract: This review examines the peer-reviewed literature describing prospective studies that report amenorrhea rates, patient satisfaction, and surgical reintervention rates following the NovaSure® endometrial ablation procedure. A search of the English-language literature published from 2000 to 2011 was conducted using PubMed. Ten prospective studies, six single-arm NovaSure trials, and four randomized controlled trials comparing the NovaSure procedure with other global endometrial ablation modalities met the inclusion criteria and were reviewed. The follow-up periods ranged from 6 to 60 months. Amenorrhea rates for the NovaSure procedure ranged from 30.0% to 75.0%. Patients who reported being satisfied with the NovaSure procedure ranged from 85.0% to 94.0%. In randomized controlled trials with other global endometrial ablation modalities, amenorrhea rates at 12 months with the NovaSure procedure ranged from 43.0% to 56.0%, while other modalities ranged from 8% to 24%. In addition, this manuscript reviews the following: the NovaSure technology; use of the NovaSure procedure in the office setting; intraoperative and postoperative pain; effects on premenstrual syndrome (PMS; dysmenorrhea; special circumstances, including presence of uterine disease, history of cesarean delivery, coagulopathy, or use of anticoagulant medication; post-procedure uterine cavity assessment and cancer risk; contraception and pregnancy; and safety. Keywords: abnormal uterine bleeding, menorrhagia, endometrial ablation, NovaSure®

  18. Ten years after the unification: East Germany and the relevance of modern theories of trade, location and growth

    OpenAIRE

    Brakman, S.; Schramm, M.; Garretsen, Harry

    2000-01-01

    In the paper we analyse, ten years after the German unification, the relevance of modern theoretical developments on trade, location and growth for East Germany using sectoral and regional data. Given our discussion of stylized facts about industry growth, economies of scale and differences in labour productivity we test for the existence of localised knowledge spillovers and a spatial wage structure in East Germany. We find that localised knowledge spillovers play a role and that a spatial w...

  19. Profiling agricultural land cover change in the North Central U.S. using ten years of the Cropland Data Layer

    Science.gov (United States)

    Sandborn, A.; Ebinger, L.

    2016-12-01

    The Cropland Data Layer (CDL), produced by the USDA/National Agricultural Statistics Service, provides annual, georeferenced crop specific land cover data over the contiguous United States. Several analyses were performed on ten years (2007-2016) of CDL data in order to visualize and quantify agricultural change over the North Central region (North Dakota, South Dakota, and Minnesota). Crop masks were derived from the CDL and layered to produce a ten-year time stack of corn, soybeans, and spring wheat at 30m spatial resolution. Through numerous image analyses, a temporal profile of each crop type was compiled and portrayed cartographically. For each crop, analyses included calculating the mean center of crop area over the ten year sequence, identifying the first and latest year the crop was grown on each pixel, and distinguishing crop rotation patterns and replacement statistics. Results show a clear north-western expansion trend for corn and soybeans, and a western migration trend for spring wheat. While some change may be due to commonly practiced crop rotation, this analysis shows that crop footprints have extended into areas that were previously other crops, idle cropland, and pasture/rangeland. Possible factors contributing to this crop migration pattern include profit advantages of row crops over small grains, improved crop genetics, climate change, and farm management program changes. Identifying and mapping these crop planting differences will better inform agricultural best practices, help to monitor the latest crop migration patterns, and present researchers with a way to quantitatively measure and forecast future agricultural trends.

  20. Motor complications in Parkinson's disease: ten year follow-up study.

    Science.gov (United States)

    López, Iria Cabo; Ruiz, Pedro J García; Del Pozo, Silvia Vázquez Fernández; Bernardos, Vicenta Sánchez

    2010-12-15

    Parkinson's disease (PD) can be symptomatically controlled with standard treatments; however, after a few years, this response typically declines and most patients develop motor complications. We carried out a prospective practice-based study to evaluate the evolution appearance and evolution of motor complications in 64 de novo PD patients over 5 years and in 38 PD patients over 10 years. We studied untreated patients from initial assessment at basal conditions and evaluated every 6 months thereafter with treatment (levodopa versus other drugs). The follow-up assessments were performed with the Unified Parkinson's Disease Rating Scale (UPDRS). At each assessment, patients were monitored regarding the development of dyskinesias, motor fluctuations, freezing, loss of postural reflexes, and cognitive impairment. We observed a significant improvement in UPDRS scores during the first year, then a progressive decline, more evident after the third year. Motor complications increased after the third year, and at the end of the survey (tenth year); drug-induced dyskinesias and motor fluctuations were experienced (71.1 and 94.7%, respectively). After the first decade, many complications arose from the non-levodopa-responsive features of the disease (cognitive impairment was present in 52.6% and gait freezing in 71.1%). Initial medication may influence medium-term complications but not long-term problems. Most long-term disabling problems of PD were related to non-levodopa-responsive features.

  1. Ten-year audit of Lichtenstein hernioplasty under local anaesthesia performed by surgical residents

    Directory of Open Access Journals (Sweden)

    Paajanen Hannu

    2010-08-01

    Full Text Available Abstract Background To analyse in a prospective trial the long-term results of Lichtenstein hernioplasty performed by surgical trainees. Methods Training of tension-free Lichtenstein hernia operation was started in our ambulatory unit as an outpatient procedure under local anaesthesia in 1996. After performing 36 teaching operations together with residents and their supervising specialist, 281 patients were operated during 1996-2000 either by one senior consultant (n = 141 or by 12 surgical trainees (n = 140. After 10 years, 247 (88% patients were available for the long-term assessment. Results After one month postoperatively, the rate of wound infections (consultant 1.1%, residents 0.7% and hematomas (consultant 1.1%, residents 3.0% were low and not related to surgeon's training level (ns. Only 6 (2.1% clinically evident recurrences were found after 10 years: two after specialist repair and four after trainee repair (ns. Although one third of the patients reported some discomfort after 3 and 10 years, 93-95% of the patients were very satisfied with the operation, with no statistical difference between the surgeons. Conclusion Ambulatory open mesh repair under local anaesthesia was a safe operation and the long-term results were acceptable among the patients operated by surgical trainees.

  2. Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On.

    Science.gov (United States)

    Everitt, Barry J; Robbins, Trevor W

    2016-01-01

    A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits, neurally underpinned by a transition from prefrontal cortical to striatal control over drug seeking and taking as well as a progression from the ventral to the dorsal striatum. Here, in the light of burgeoning, supportive evidence, we reconsider and elaborate this hypothesis, in particular the refinements in our understanding of ventral and dorsal striatal mechanisms underlying goal-directed and habitual drug seeking, the influence of drug-associated Pavlovian-conditioned stimuli on drug seeking and relapse, and evidence for impairments in top-down prefrontal cortical inhibitory control over this behavior. We further review animal and human studies that have begun to define etiological factors and individual differences in the propensity to become addicted to drugs, leading to the description of addiction endophenotypes, especially for cocaine addiction. We consider the prospect of novel treatments for addiction that promote abstinence from and relapse to drug use.

  3. Ten-year follow up after laparoscopic suture rectopexy for full-thickness rectal prolapse.

    Science.gov (United States)

    Foppa, C; Martinek, L; Arnaud, J P; Bergamaschi, R

    2014-10-01

    Studies have shown that recurrence rates of full-thickness rectal prolapse (FTRP) 5 years after surgery can quadruple at 10 years. This study aimed to evaluate the impact of laparoscopic suture rectopexy for FTRP on recurrence rates and functional outcome at a median follow up of 10 years. Prospectively collected data for patients who underwent laparoscopic suture rectopexy for FTRP between 1993 and 2006 were analysed. Laparoscopic rectopexy consisted of circumferential mobilization of the rectum down to the levator followed by suture suspension to promontory. Patients with preexisting constipation or who were unfit for general anaesthesia were not included. Incontinence, quality of life and constipation were assessed by validated scores. Recurrence-free curves were generated using the Kaplan-Meier method. One hundred and seventy-nine patients with a median age of 62 (15-93) years including 174 women and five men underwent laparoscopic suture rectopexy. There was no mortality. The 30-day complication rate was 4% (partial transection of the left ureter, pneumonia, urinary tract infection, urinary retention, superficial surgical site infection). Data on 172 patients (96%) were available at follow up. There were 10 recurrences of FTRP at 5-year follow up giving a crude recurrence rate of 6%. The actuarial 10-year recurrence rate was 20% (95% CI, 10.8-20.1). Follow-up continence (P < 0.0001) and quality of life were better than preoperatively: lifestyle (P < 0.001), coping (P < 0.001), self-perception (P < 0.005), embarrassment (P < 0.06). Constipation was unchanged. Laparoscopic suture rectopexy led to few complications, a recurrence rate of 20%, improved continence and quality of life with no worsening of constipation at 10 years. Colorectal Disease © 2014 The Association of Coloproctology of Great Britain and Ireland.

  4. Residential relocations among older people over the course of more than ten years

    Science.gov (United States)

    Buurman, Bianca M.; Trentalange, Mark; Nicholson, Nicholas; McGloin, Joanne M.; Gahbauer, Evelyne A.; Allore, Heather G.; Gill, Thomas M.

    2014-01-01

    Objective To describe the rates of residential relocations over the course of 10.5 years and evaluate differences in these relocation rates according to gender and decedent status. Design Prospective, longitudinal study with monthly telephone follow-up for up to 126 months. Setting Greater New Haven, Connecticut. Participants 754 persons, aged 70 years or older, who were initially community-living and nondisabled in their basic activities of daily living. Measurements Residential location was assessed during monthly interviews and included: community, assisted living facility (AL) and nursing home (NH). A residential relocation was defined as a change of residential location for at least one week and included relocations within (e.g. community-community) or between (community-assisted living) locations. We calculated the rates of relocations/1000 patient-months and evaluated differences by gender and decedent status. Results Sixty-six percent of participants had at least one residential relocation (range 0–12). Women had lower rates of relocations from NH to community (rate ratio (RR) 0.59, p=.02); otherwise, there were no gender differences. Decedents had higher rates of relocation from community to AL (RR 1.71, p=0.002), from community to NH (RR 3.64, p<.001), between ALs (RR 3.65, p<.001) and from AL to NH (RR 2.5, p<0.001). In decedents, relocations from community to NH (RR 3.58, p<.001) and from AL to NH (RR 3.3, p<.001) were most often observed in the last year of life. Conclusions A majority of older people relocated at least once during 10.5 years follow-up. Women had lower rates of relocation from NH to community. Decedents were more likely to relocate to a residential location providing a higher level of assistance, compared with non-decedents. Residential relocations were most common in the last year of life. PMID:24794829

  5. Problem behaviours, caregiver mental health symptoms and health service use in Australian children with cystic fibrosis: a prospective cohort study

    OpenAIRE

    Sheehan, Jane

    2017-01-01

    Background: Cystic fibrosis (CF) is an inherited, recessive condition, primarily affecting the respiratory and digestive systems. The current median life expectancy for adults with CF is approximately 37 years. Children with CF endure an intensive daily treatment regimen including dietary requirements, pancreatic enzyme replacements, vitamin supplementation, regular antibiotics, and airway clearance, in order to maintain their health status and reduce CF symptoms. The treatment regimen is ...

  6. Nuclear Society of Russia: Ten years in the world nuclear community

    Energy Technology Data Exchange (ETDEWEB)

    Ponomarev-Stepnoi, N.N.; Gagarinski, A.Yu.

    2000-07-01

    the analysis of nuclear energy production trends and--most importantly for relations with the mass media and the public--crisis information (latest examples: Tokaimura, the virtual Y2K crisis, etc.), have become important sources of information for the NSR. It should be emphasized that the financial participation of the Russian Minatom (maintained at the insistent request of the NSR) in the NucNet system provides sufficiently wide dissemination of operative nuclear information not only through the NSR headquarters but also via its regional branches and separate enterprises. From its side, NSR has assumed the responsibility for the adequate flow of information on Russian nuclear events to NucNet. As a living and developing organism, the NSR wants to respond to its time's challenges. Several prospective directions could be among the NSR information exchange plans: (1) Independent international analysis of the problems of the use of nuclear energy, which is presently in a stagnation period but with future large-scale development, is as possible today as it never had been before. (2) In the field of public relations, many achievements of Russian and US specialists (in the form of articles, analyzing nuclear energy on the popular and highly professional level) stay inaccessible to others because of the language barrier. A possible joint ANS/NSR project on selection, translation, and exchange of such materials, with their further wide publication, represents an obvious reserve in their societies' information activities. (3) The International Youth Nuclear Congress project (proposed by the Russian nuclear youth and supported by ANS and ENS), conceived as a bridge between generations and a forum for opinion exchange between young nuclear specialists from various countries, deserves further development and appropriation of permanent status in the activities of the world nuclear societies.

  7. Preparing Science-Trained Professionals for the Biotechnology Industry: A Ten-Year Perspective on a Professional Science Master's Program.

    Science.gov (United States)

    Hamilton, Paul T; Luginbuhl, Sarah C; Hyman, Michael

    2012-01-01

    The biotechnology industry has a need for business-savvy scientists; however, this is not the way scientists are traditionally trained at universities and colleges. To address this need, universities have developed Professional Science Master's (PSM) degree programs that offer advanced training in a technical field along with professional skills development through team-based projects and internships. Nearly ten years ago, the Department of Microbiology at NCSU started a PSM program in Microbial Biotechnology (MMB). This article provides an overview of the MMB program, and shares some of the lessons that we have learned.

  8. [Late results of the "simplified technique" in the surgical management of a thoracoabdominal aortic aneurysm, ten years later - clinical report].

    Science.gov (United States)

    Dinis da Gama, A

    2007-01-01

    The authors report the clinical case of a dissecting thoracoabdominal aortic aneurysm, in a 49-years old female, with the diagnosis of Marfan's syndrome, who underwent surgical treatment utilizing the "simplified technique", introduced by ourselves in 1983, for the management of this most demanding situation. Reviewed ten years later, having reassumed her social and professional life, a control angio-CT disclosed the procedure of aortic reconstruction and the revascularization of the digestive and renal arteries working in excellent condition. The unique and singular reconstructive procedure here utilized and its excellent long term result, justify its presentation and divulgation.

  9. A Review of Ten Years of the Study for Monitoring Antimicrobial Resistance Trends (SMART from 2002 to 2011

    Directory of Open Access Journals (Sweden)

    Douglas Biedenbach

    2013-11-01

    Full Text Available Surveillance of antimicrobial agent resistance provides important information to guide microbiologists and infectious disease specialists understanding of the control and the spread of resistance mechanisms within the local environment. Continued monitoring of antimicrobial resistance patterns in the community and in local hospital environments is essential to guide effective empiric therapy. The Study for Monitoring Antimicrobial Resistance Trends (SMART has monitored the in vitro susceptibility patterns of clinical Gram-negative bacilli to antimicrobial agents collected worldwide from intra-abdominal infections since 2002 and urinary tract infections since 2009. Resistance trends, with a particular focus on carbapenem resistance and the rate of extended-spectrum β-lactamases (ESBLs, were analyzed. Isolates from intra-abdominal infections (n = 92,086 and urinary-tract infections (n = 24,705 were collected and tested using Clinical and Laboratory Standards Institute methods. This review presents carbapenem susceptibility and ESBL rates over ten years of SMART study analysis, including key publications during this period. The SMART study has proved to be a valuable resource in determining pathogen prevalence and antibiotic susceptibility over the last ten years and continues to provide evidence for regulatory susceptibility breakpoints and clinical decision making.

  10. Ten-year experience with mission-based budgeting in the faculty of medicine of Dalhousie University.

    Science.gov (United States)

    Ruedy, John; MacDonald, Noni E; MacDougall, Brian

    2003-11-01

    The Faculty of Medicine of Dalhousie University (the Faculty) has applied a mission-based approach to the allocation of the academic budget since 1993. Over the ensuing decade, large shifts in budgets to academic departments have been effected, and two goals that required special emphasis-the successful implementation of a tutorial-based undergraduate medical curriculum and an increase in research activity-have been achieved. This has occurred despite significant reductions in the overall academic budget over the ten-year period. The budgeting process provided the Faculty with a tangible means of supporting its mission and also gave each department a transparent report of its relative contribution to the overall mission of the Faculty, which helped instill pride. In some years, misunderstandings of the budget process arose because of confusion over the impact of the overall total academic budget reductions experienced by the Faculty in that year. This meant that recognition of a department's contribution resulted, in most instances, in a relatively smaller reduction in budget rather than a budget increase. Further misunderstandings have arisen because of confusion between mission-based and activity-based budgeting. This confusion was reinforced because the assessments of education outcomes were measurements of activity rather than of outcomes. However, these measures were chosen to be the best-available indirect measures of the desired educational outcome. After ten years, the fundamentals of the mission-based process introduced in 1993 remain unchanged as the basis for allocation of the academic budget for the Faculty.

  11. Report on Non-fatal events cardio-cerebro-vascular to ten years in a Southern Italy cohort.

    Science.gov (United States)

    Capuano, Vincenzo; Lamaida, Norman; Capuano, Rocco; Capuano, Eduardo; Torre, Sergio; Marchese, Federica; Capuano, Ernesto

    2014-12-01

    Data relating to non-fatal cardiovascular events are poor but these data are essential to organize targeted interventions on the territory and to understand their effectiveness. We calculated the rates of morbidity from cardiovascular events covering the period 1998/99-2008/09, in a cohort of 1200 persons (600 men and 600 women) aged 25 to 74 years. Data were standardized using the European standard population. The incidence of events to ten years of non-fatal myocardial infarc.ion was 2.2% in men and of 1.8% in women. PCI interventions to ten year have been 3.3% in men and 3.4% in women, the interventions of aorto-coronary bypass have been 2.4% and 0.5% for men and women respectively. While all major cardiovascular events have been more frequent in men, in women there was a higher incidence of stroke (1.6% vs 0.9%). Although by comparison with other European countries Italy is among the countries considered at low-risk of coronary heart disease, in Campania cardiovascular diseases reach higher rates than the rest of the country. Our results are in keeping with the literature data and confirm that cardiovascular diseases are a major public health problem. Local analysis are useful in providing additional information for planning prevention interventions targeted to its own territory.

  12. Ten Years of Chandra

    Science.gov (United States)

    Weisskopf, Martin C.

    2009-01-01

    We celebrated the 10-th anniversary of the Launch of the Chandra X-ray Observatory on July 13, 2009. During these 10 years data from this Great Observatory have had a profound impact on 21st century astrophysics. With its unrivaled capability to produce sub-arcsecond images, the Observatory has enabled astronomers to make new discoveries in topics as diverse as comets and cosmology. We shall review some of the highlights, discuss the current status, and future plans.

  13. Ten Years of CERI.

    Science.gov (United States)

    Hameyer, Uwe

    1980-01-01

    Reports on the activities of the Centre for Educational Research and Innovation (CERI) within the last 10 years and in the future. Topics include mathematics instruction, lifelong learning, environmental education at the university level, inservice and preservice education and education for the handicapped adolescent. (SA)

  14. Peer-review and editorial process of the Ethiopian Medical Journal: ten years assessment of the status of submitted manuscripts.

    Science.gov (United States)

    Enquselassie, Fikre

    2013-04-01

    The Ethiopian Medical Journal (EMJ) is a peer-reviewed journal, now 50 years old. Many medical journals, including EMJ, follow a peer review system that has evolved from the 18th century process for reviewing submitted manuscripts. However, not much is known about peer review and editorial processes by many authors who submit manuscripts to the EMJ. To describe procedures related to EMJ peer-review and editorial decision making and asses the status of manuscripts submitted to the journal in the ten year period between 2001 and 2010. All the minutes of the editorial board meetings of the ten years period 2001-2010 and relevant documents were reviewed. The minutes have details including date of submission, dates to and from reviewers, date of decision, number of assigned peer reviewers and comments given by reviewers for each submitted manuscript. The length of time took in the processes and the decision made (accepted or rejected) for each submitted manuscript was calculated from the dates. All submitted manuscripts passed through three stages: internal per-review by an editorial board member, external peer review by selected reviewers and final editing stage by an assigned editorial member. A total of 615 manuscripts were submitted to EMJ in the ten years period 2001-2010. Five hundred and one (82.7%) manuscripts were accepted for publication by peer reviewers, while 74 (12.2%) were rejected and 31 (5.1%) were withdrawn. Acceptance was lowest among original articles (81.3%) followed by teaching or review articles (84.3%) and case reports (89.3%). Thirty-two (8.4%) manuscripts were accepted within 6 months following submission and 50% were accepted within in one year of submission. About 6% of manuscripts were delayed for more than two years with a maximum delay of 43 months. Even though, there is a decline trend on the delay of processing manuscripts, EMJ has long to go in order to improve the quality of the journal and shorten the slow peer review process

  15. Ten years of a model of aesthetic appreciation and aesthetic judgments : The aesthetic episode - Developments and challenges in empirical aesthetics.

    Science.gov (United States)

    Leder, Helmut; Nadal, Marcos

    2014-11-01

    About a decade ago, psychology of the arts started to gain momentum owing to a number of drives: technological progress improved the conditions under which art could be studied in the laboratory, neuroscience discovered the arts as an area of interest, and new theories offered a more comprehensive look at aesthetic experiences. Ten years ago, Leder, Belke, Oeberst, and Augustin (2004) proposed a descriptive information-processing model of the components that integrate an aesthetic episode. This theory offered explanations for modern art's large number of individualized styles, innovativeness, and for the diverse aesthetic experiences it can stimulate. In addition, it described how information is processed over the time course of an aesthetic episode, within and over perceptual, cognitive and emotional components. Here, we review the current state of the model, and its relation to the major topics in empirical aesthetics today, including the nature of aesthetic emotions, the role of context, and the neural and evolutionary foundations of art and aesthetics.

  16. Ipsilateral combination of Galeazzi and Monteggia fractures in a ten-year-old patient: a case report.

    Science.gov (United States)

    Akalin, Yavuz; Akinci, Orhan; Kayali, Cemil

    2010-01-01

    Galeazzi fractures represent approximately 3 to 6 percent of forearm fractures, whereas Monteggia fractures represent 1 to 2 percent. The combination of these injuries in the same extremity is an exceedingly rare occurrence. We report a case of ipsilateral combination of Galeazzi and Monteggia fractures in a ten-year-old patient. The patient was treated with closed reduction and internal fixation with Kirschner pins. The distal radioulnar and radiocapitellar joint relationships were restored and the fractures healed. The patient proceeded to obtain a satisfactory functional result three years later. Internal fixation is a safe method for such complex forearm fractures in older children and allows post-operative rehabilitation with the advantage of early mobilization.

  17. The statistical analysis of failure of a MEVATRON77 DX67 linear accelerator over a ten year period

    CERN Document Server

    Aoyama, H; Tahara, S; Uno, H; Kadohisa, S; Azuma, Y; Nakagiri, Y; Hiraki, Y

    2003-01-01

    A linear accelerator (linac) takes a leading role in radiation therapy. A linac consists of complicated main parts and systems and it is required that highly accurate operational procedures should be maintained. Operational failure occurs for various reasons. In this report, the failure occurrences of one linac over a ten year period were recorded and analyzed. The subject model was a MEVATRON77 DX67 (Siemens, Inc). The failure rate for each system, the form classification of the contents of failure, the operation situation at the time of failure, and the average performance life of the main parts were totaled. Moreover, the relation between the number of therapies that patients received (operating efficiency) and the failure rate within that number and the relation between environment (temperature and humidity) and the failure rate attributed to other systems were analyzed. In this report, irradiation interruption was also included with situations where treatment was unable to begin in total for the number o...

  18. Ten-year performance of Influenzanet: ILI time series, risks, vaccine effects, and care-seeking behaviour

    Directory of Open Access Journals (Sweden)

    Sander P. van Noort

    2015-12-01

    Full Text Available Recent public health threats have propelled major innovations on infectious disease monitoring, culminating in the development of innovative syndromic surveillance methods. Influenzanet is an internet-based system that monitors influenza-like illness (ILI in cohorts of self-reporting volunteers in European countries since 2003. We investigate and confirm coherence through the first ten years in comparison with ILI data from the European Influenza Surveillance Network and demonstrate country-specific behaviour of participants with ILI regarding medical care seeking. Using regression analysis, we determine that chronic diseases, being a child, living with children, being female, smoking and pets at home, are all independent predictors of ILI risk, whereas practicing sports and walking or bicycling for locomotion are associated with a small risk reduction. No effect for using public transportation or living alone was found. Furthermore, we determine the vaccine effectiveness for ILI for each season.

  19. Favourable ten-year overall survival in a Caucasian population with high probability of hereditary breast cancer

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    Pasini Giuseppe

    2010-03-01

    Full Text Available Abstract Background The purpose of our study was to compare differences in the prognosis of breast cancer (BC patients at high (H risk or intermediate slightly (IS increased risk based on family history and those without a family history of BC, and to evaluate whether ten-year overall survival can be considered a good indicator of BRCA1 gene mutation. Methods We classified 5923 breast cancer patients registered between 1988 and 2006 at the Department of Oncology and Haematology in Modena, Italy, into one of three different risk categories according to Modena criteria. One thousand eleven patients at H and IS increased risk were tested for BRCA1/2 mutations. The overall survival (OS and disease free survival (DFS were the study end-points. Results Eighty BRCA1 carriers were identified. A statistically significantly better prognosis was observed for patients belonging to the H risk category with respect to women in the IS and sporadic groups (82% vs.75% vs.73%, respectively; p BRCA1 carriers with BRCA-negative and sporadic BC (77% vs.77% vs.73%, respectively; p Conclusions Patients belonging to a population with a high probability of being BRCA1 carriers had a better prognosis than those with sporadic BC. Considering these results, women who previously had BC and had survived ten years could be selected for BRCA1 analysis among family members at high risk of hereditary BC during genetic counselling. Since only 30% of patients with a high probability of having hereditary BC have BRCA1 mutations, selecting women with a long term survival among this population could increase the rate of positive analyses, avoiding the use of expensive tests.

  20. The occurrence of osteoarthritis at a minimum of ten years after reconstruction of the anterior cruciate ligament

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    Patt Thomas W

    2008-06-01

    Full Text Available Abstract Objective The objective of this study was to evaluate the incidence of radiographic osteoarthritis in the operated knee in comparison with the contralateral knee ten years after a bone-tendon bone patellar autograft ACL-reconstruction and to evaluate to which level patients regain activity ten years after reconstruction. Methods Fifty-three patients with ACL instability were operated arthroscopically using the central third of the patellar tendon as a bone-tendon-bone autograft. At a minimum of 10 year follow up 28/44 patients matched the inclusion criteria and could be reached for follow-up. Evaluation included a patient satisfaction evaluation using a Visual Analog Scale, physical examination (International Knee Documentation Committee score, Tegner score, Lysholm score, KT-1000 stabilometry and a radiological evaluation (Kellgren and Fairbanks classification. Results The patients' satisfaction, at a mean of 10,3 year follow-up, measured with a VAS score (0–10 was high with a mean of 8.5 (range 4 to 10. The KT 1000 arthrometer laxity measurements revealed in 55% of the patients an A rating (1–2 mm, in 29% a B rating (3–5 mm and in 16% a C rating (6–10 mm. According to the Tegner score 54% of the patients were able to perform at the same activity level as pre-operatively. The mean pre-operative Tegner score was 6.8 and the mean post-operative Tegner score was 6.0 at final follow up. The Lysholm score showed satisfactory results with a mean of 91 points (range 56 to 100. According to the Kellgren and Fairbank classifications, there is a significant difference (p Conclusion The patellar BTB ACL reconstruction does not prevent the occurrence of radiological OA after 10 years but does help the patient to regain the pre-operative level of activity.

  1. Efficacy of thrombomodulin for acute exacerbation of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia: a nonrandomized prospective study

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    Abe M

    2015-10-01

    Full Text Available Mitsuhiro Abe, Kenji Tsushima, Takuma Matsumura, Tsukasa Ishiwata, Yasunori Ichimura, Jun Ikari, Jiro Terada, Yuji Tada, Seiichirou Sakao, Nobuhiro Tanabe, Koichiro Tatsumi Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan Purpose: Acute exacerbation (AE is an important outcome of idiopathic pulmonary fibrosis (IPF and nonspecific interstitial pneumonia (NSIP. Recombinant human soluble thrombomodulin (rhTM is a new drug for the treatment of disseminated intravascular coagulation in Japan. The objective of this study was to evaluate the efficacy of rhTM for AE of IPF/NSIP.Methods: Twenty-two patients with AE-idiopathic interstitial pneumonia (16 patients with IPF and six patients with NSIP were enrolled in our study. Among them, eleven patients were treated with rhTM (rhTM group, and eleven patients were treated without rhTM (non-rhTM group. Patients admitted to our hospital prior to December 2013 were treated with rhTM, while those admitted after January 2014 were treated without rhTM. The primary endpoint was mortality at 90 days after AE treatment. The secondary endpoint was the safety of rhTM for AE-IPF/AE-NSIP. In addition, we examined prognostic factors of AE-IPF/AE-NSIP.Results: The mortality rate was significantly lower in the rhTM group than in the non-rhTM group (mortality rate at 90 days: 36% vs 90%, P=0.023; median survival time: not reached vs 15.0 days, P=0.019. A univariate analysis revealed the respiratory rate (hazard ratio [HR] 1.09, 95% confidence interval [CI] 1.00–1.18, P=0.039 and rhTM administration (HR 0.21, 95% CI 0.06–0.77, P=0.013 as predictors of mortality at 90 days, and a multivariate analysis identified rhTM administration (HR 0.025, 95% CI 0.0006–0.94, P=0.046 as an independent predictor of mortality at 90 days. No serious adverse events were observed.Conclusion: The administration of rhTM is associated with reductions in mortality in patients with AE

  2. Pulmonary Fibrosis

    Science.gov (United States)

    Pulmonary fibrosis is a condition in which the tissue deep in your lungs becomes scarred over time. This ... blood may not get enough oxygen. Causes of pulmonary fibrosis include environmental pollutants, some medicines, some connective tissue ...

  3. Feature changes of rheumatic fever in last ten years%近十年风湿热的演变

    Institute of Scientific and Technical Information of China (English)

    谢旭晶; 徐莉; 陈磷; 魏秋静; 余步云

    2009-01-01

    Objective To investigate the changes of clinical and laboratory manifestations of rheumatic fever (RF) in recent ten years by reviewing the medical data of 315 patients with RF. Methods Three hundred and fifteen in-patients and out-patients with RF during 1985-1995 (group A) and 1997-2007(group B) were selected. Their manifestations were compared. Results Male/female ratio was about 1:2. Carditis and polyarthritis were common manifestations. Compared with group A, the rate of low-grade fever and carditis increased and the rate of heart failure, positive rate of C reaction protein and antistreptolysin O decreased in group B. In group B, 61.4% patients fulfilled the updated Jones diagnostic criteria. 76.2% fulfilled the 2002-2003 WHO criteria. The sensitivity and specificity of peripheral blood lymphocyte procoagulant activity (PCA) for the diagnosis of rheumatic carditis was 79.1% and 71.4% respectively. That of the anti-streptococcal group A polysaccharide (ASP) antibodies was 70.3% and 70% respectively. Five to ten years follow-up clinical data were available for 35 cases since Dec. 1997. The recurrent rate of RF was 62.8%. Only 1/3 cases received regular secondary prevention. Recurrence rate of patients with regular secondary prevention was significantly lower than that of patients without regular secondary prevention. Conclusion Mild earditis has been increasing during last ten years. PCA and ASP are valuable tests for diagnosing rheumatic carditis. More emphasis should be paid to atypical cases, early diagnosis and regular secondary prevention in order to improve prognosis.%目的 探讨近十年风湿热临床表现及实验室榆查的变化,为诊断及治疗提供参考.方法 收集我院风湿热患者共315例,分为2组,1985-1995年就诊的为A组,1997-2007年就诊的为B组,比较2组的临床表现及实验室检查.结果 男:女为1:2.心脏炎、多关节炎仍是最常见的症状.与A组比较,B组低热、心脏炎增加,心力衰竭减少,C

  4. Does present use of cardiovascular medication reflect elevated cardiovascular risk scores estimated ten years ago? A population based longitudinal observational study

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    Straand Jørund

    2011-03-01

    Full Text Available Abstract Background It is desirable that those at highest risk of cardiovascular disease should have priority for preventive measures, eg. treatment with prescription drugs to modify their risk. We wanted to investigate to what extent present use of cardiovascular medication (CVM correlates with cardiovascular risk estimated by three different risk scores (Framingham, SCORE and NORRISK ten years ago. Methods Prospective logitudinal observational study of 20 252 participants in The Hordaland Health Study born 1950-57, not using CVM in 1997-99. Prescription data obtained from The Norwegian Prescription Database in 2008. Results 26% of men and 22% of women aged 51-58 years had started to use some CVM during the previous decade. As a group, persons using CVM scored significantly higher on the risk algorithms Framingham, SCORE and NORRISK compared to those not treated. 16-20% of men and 20-22% of women with risk scores below the high-risk thresholds for the three risk scores were treated with CVM, while 60-65% of men and 25-45% of women with scores above the high-risk thresholds received no treatment. Among women using CVM, only 2.2% (NORRISK, 4.4% (SCORE and 14.5% (Framingham had risk scores above the high-risk values. Low education, poor self-reported general health, muscular pains, mental distress (in females only and a family history of premature cardiovascular disease correlated with use of CVM. Elevated blood pressure was the single factor most strongly predictive of CVM treatment. Conclusion Prescription of CVM to middle-aged individuals by large seems to occur independently of estimated total cardiovascular risk, and this applies especially to females.

  5. Patterns and predictors of sitting time over ten years in a large population-based Canadian sample: Findings from the Canadian Multicentre Osteoporosis Study (CaMos).

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    Gebel, Klaus; Pont, Sarah; Ding, Ding; Bauman, Adrian E; Chau, Josephine Y; Berger, Claudie; Prior, Jerilynn C

    2017-03-01

    Our objective was to describe patterns and predictors of sedentary behavior (sitting time) over 10 years among a large Canadian cohort. Data are from the Canadian Multicentre Osteoporosis Study, a prospective study of women and men randomly selected from the general population. Respondents reported socio-demographics, lifestyle behaviors and health outcomes in interviewer-administered questionnaires; weight and height were measured. Baseline data were collected between 1995 and 1997 (n = 9418; participation rate = 42%), and at 5- (n = 7648) and 10-year follow-ups (n = 5567). Total sitting time was summed across domain-specific questions at three time points and dichotomized into "low" (≤ 7 h/day) and "high" (> 7 h/day), based on recent meta-analytic evidence on time sitting and all-cause mortality. Ten-year sitting patterns were classified as "consistently high", "consistently low", "increased", "decreased", and "mixed". Predictors of sedentary behavior patterns were explored using chi-square tests, ANOVA and logistic regression. At baseline (mean age = 62.1 years ± 13.4) average sitting was 6.9 h/day; it was 7.0 at 5- and 10-year follow-ups (p for trend = 0.12). Overall 23% reported consistently high sitting time, 22% consistently low sitting, 14% decreased sitting, 17% increased sitting with 24% mixed patterns. Consistently high sitters were more likely to be men, university educated, full-time employed, obese, and to report consistently low physical activity levels. This is one of the first population-based studies to explore patterns of sedentary behavior (multi-domain sitting) within men and women over years. Risk classification of sitting among many adults changed during follow-up. Thus, studies of sitting and health would benefit from multiple measures of sitting over time.

  6. Malaria in pregnancy; facts from the parasitology laboratory: a ten-year study in Abuja, North Central Nigeria

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    Ibecheozor, N.K.O

    2014-09-01

    Full Text Available Malaria, which is transmitted by female Anopheles mosquitoes, is the major cause of mortality among the pregnant women in the sub-Saharan Africa. A ten year study of malaria in pregnancy was carried out in Abuja, North Central Nigeria. Thick and thin blood films were stained with the Giemsa methodology. Of the 16760 pregnant women blood samples, 4571 (27.3% were positive for malaria parasites caused by Plasmodium falciparum. Of the 4571 positive cases, 75 (1.7% had parasite density of >5000 parasites/µl of blood; 148 (3.2% had between 500-5000 parasites/µl of blood; 520 (11.4% had between 50 - 500 parasites/µl of blood; while 3828 (83.7% had between 5-50 parasites/µl of blood. With the current estimate of over 4500 deaths of pregnant women in Nigeria due to malaria annually, we must make deliberate efforts to stop these unacceptable and painful losses. The continued use of malaria rapid diagnostic tests (M-RDTs methodologies should be discontinued because of its negative implications. Therefore, the microscopic laboratory diagnostic component should be included in ANC at all level of health care facility.

  7. Resistance of herpes simplex viruses to acyclovir: an update from a ten-year survey in France.

    Science.gov (United States)

    Frobert, Emilie; Burrel, Sonia; Ducastelle-Lepretre, Sophie; Billaud, Geneviève; Ader, Florence; Casalegno, Jean-Sébastien; Nave, Viviane; Boutolleau, David; Michallet, Mauricette; Lina, Bruno; Morfin, Florence

    2014-11-01

    The widespread use of acyclovir (ACV) and the increasing number of immunocompromised patients have raised concern about an increase in ACV-resistant herpes simplex virus (HSV). ACV resistance has traditionally been a major concern for immunocompromised patients with a frequency reported between 2.5% and 10%. The aim of this study was to reassess the status of HSV resistance to ACV in immunocompetent and immunocompromised patients over a ten year period, between 2002 and 2011. This was done by retrospectively following 1425 patients. In immunocompetent patients, prevalence of resistance did not exceed 0.5% during the study period; whereas in immunocompromised patients, a significant increase was observed, rising from 3.8% between 2002 and 2006 (7/182 patients) to 15.7% between 2007 and 2011 (28/178) (p=0.0001). This sharp rise in resistance may largely be represented by allogeneic hematopoietic stem cell transplant patients, in which the prevalence of ACV resistance rose similarly from 14.3% (4/28) between 2002 and 2006 to 46.5% (26/56) between 2007 and 2011 (p=0.005). No increase in ACV resistance was detected in association with other types of immune deficiencies. Genotypic characterization of HSV UL23 thymidine kinase and UL30 DNA polymerase genes revealed 11 and 7 previously unreported substitutions, respectively. These substitutions may be related to potential polymorphisms, drug resistance, or other mutations of unclear significance.

  8. A ten year (1999-2008) retrospective study of amoebiasis in University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia.

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    Farhana, F; Jamaiah, I; Rohela, M; Abdul-Aziz, N M; Nissapatorn, V

    2009-12-01

    This is a ten year (1999-2008) retrospective study of amebiasis in patients admitted to UMMC. A total of 34 cases were analyzed. The most common were amebic liver abscess 22(65%) and the rest were amoebic dysentery 12(35%). Majority of the cases occurred among Malaysians 29(85%), with Chinese 14(41%), followed by the Malays 9(26%) and the Indians 6(18%). Foreigners made up of one Indonesian, one Pakistani and three Myanmarese and constituted 5(15%) of the total cases. Males 24(71%) were more commonly affected. Most of the cases occurred between the age group of 40-49 years, 8(23%) and 60 years and above, 8(23%). Age group of 20-50 years constituted 20(60%) of the cases. The most common clinical presentations were fever with chills and rigors 26(76%), diarrhoea 20 (59%), right hypochondrium pain 17(50%), abdominal pain 17(50%), hepatomegaly 16 (47%) and jaundice 7(20%). All were discharged well after treatment except for one case of death in a 69-year-old Chinese male with amebic liver abscess.

  9. Ten-year experiences with Tetanus at a Tertiary hospital in Northwestern Tanzania: A retrospective review of 102 cases

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    Mshana Stephen E

    2011-07-01

    Full Text Available Abstract Background Tetanus is still a major health problem in developing countries and it is associated with a high morbidity and mortality rate. There is paucity of published data regarding the management of tetanus in Tanzania, especially the study area. This study was conducted to describe our own experiences with tetanus outlining the clinical characteristics and treatment outcome of tetanus patients in our environment and to identify predictors of outcome of these patients. Methods This was a ten-year period retrospective study of patients who presented with a clinical diagnosis of tetanus at Bugando Medical Centre between January 2001 and December 2010. Data was analyzed using SPSS computer software system. Results A total of 102 patients were studied. The male to female ratio was 11.8: 1. The majority of patients (74.5% were aged Conclusion Tetanus remains a major public health problem in our centre and still carries unacceptably high morbidity and mortality despite the available advanced management facilities including ICU care. Young adult males are commonly affected. The incidence of tetanus can be reduced significantly by an effective immunization program and proper wound management of the patients. Early recognition, intense support and prompt treatment improves morbidity and mortality of patients diagnosed with tetanus.

  10. Do Karst Rivers “deserve” their own biotic index? A ten years study on macrozoobenthos in Croatia

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    Rađa Biljana

    2010-07-01

    Full Text Available In this study we present the results of a ten year survey of the aquatic macroinvertebrate fauna along four karst rivers: Jadro, Žrnovnica, Grab and Ruda, all of them situated in the Middle Dalmatia region of Croatia, in an attempt to construct the Iliric Biotic Index, which will be more applicable for the water quality analysis than the most frequently applied biotic index in Croatia, the Italian Modification of Extended Biotic Index. The rivers geologically belong to the Dinaric karst, unique geological phenomena in Europe. Benthic macroinvertebrates were collected along each river at 15 sites by standard methods of sampling along with several physicochemical parameters, including: temperature, dissolved oxygen, carbon dioxide, alkalinity, hardness and pH. Univariate and multivariate techniques revealed differences in the macroinvertebrate community structure as well as in physicochemical parameters between the Karst rivers and continental rivers. Based on those differences, the Iliric Biotic Index was proposed as the standard of karst river water quality in Croatia in accordance with the EU Water Framework Directive. Differences between the Iliric Biotic Index and the most commonly used biotic indices in the European Community and the USA (The Biological Monitoring Working Party (B.M.W.P. scores, i.e. Extended Biotic Index, Indice Biotique, Family Biotic Index suggest that karst rivers need a new biotic index.

  11. Vaccine Adverse Events Reported during the First Ten Years (1998–2008 after Introduction in the State of Rondonia, Brazil

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    Mônica P. L. Cunha

    2013-01-01

    Full Text Available Despite good safety records, vaccines given to young children can cause adverse events. We investigated the reported adverse events following immunization (AEFI of vaccines given to children of less than seven years of age during the first ten years (1998 to 2008 in the state of Rondonia, Brazil. We worked with the events related to BCG (Bacillus Calmett-Guérin, HB (hepatitis B, DTwP/Hib (diphtheria-tetanus-pertussis+Hemophillus influenza b, DTP (diphtheria-tetanus-pertussis, MMR (mumps, measles, rubella, and YF (yellow fever vaccines because they were part of the recommended scheme. The number of doses of vaccines given was 3,231,567 with an average of AEFI of 57.2/year during the studied period. DTwP/Hib was responsible for 298 (57.8%, DTP 114 (22.9%, HB 31 (6%, MMR 28 (5.4%, BCG 24 (4.7%, and YF 20 (3.9% of the reported AEFI. The combination of the AEFI for DTwP/Hib vaccines showed the highest number of systemic (61.4% and local events (33.8%. Young children (≤1-year old were more susceptible to AEFI occurring in the 6 hours (54.2% following vaccine uptake. This study suggests significant differences in reactogenicity of vaccines and that despite limitations of the AEFI Brazilian registry system we cannot ignore underreporting and should use the system to expand our understanding of adverse events and effects.

  12. The Framework Convention on Tobacco Control, ten years later: the regulatory function of OMS to the rescue of global health?

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    KASTLER, Florian

    2016-06-01

    Full Text Available This article analyzes the implementation of the Framework Convention on Tobacco Control (FCTC ten years after its entry into force in 2005, when it was received as a binding legal healthy, innovative and international, instrument. Considered as a symptom of the strong normative function of the World Health Organization (WHO, in accordance with Article 19 of its Constitution, the FCTC could respond to the expectation to become an example to be followed in the creation of new legal instruments of global health. After analyzing the influence of the Convention in national legal systems and its impact on the health of individuals, this article examines the elements that contributed to its approval and the continuing difficulties for its implementation. The analysis shows that if the results in the fight against smoking are promising, based on the experience of the FCTC, some lessons were learned: first, to improve the monitoring and control system to implement the Convention; and second, to consider new ambitious instruments in other areas of health. It seems that these instruments should be adapted to the specific contexts of each health challenge. More generally, in the context of reform, this article demonstrates that the proper use of the normative function offers a response to the criticism being made to WHO, questioning its legitimacy and credibility as an institution focused on global health.

  13. Ten-year results of a randomized trial comparing tacrolimus versus cyclosporine a in combination with mycophenolate mofetil after heart transplantation.

    Science.gov (United States)

    Guethoff, Sonja; Meiser, Bruno M; Groetzner, Jan; Eifert, Sandra; Grinninger, Carola; Ueberfuhr, Peter; Reichart, Bruno; Hagl, Christian; Kaczmarek, Ingo

    2013-02-27

    Long-term results of prospective randomized trials comparing triple immunosuppressive strategies combining tacrolimus (TAC) or cyclosporine A (CsA) with mycophenolate mofetil (MMF) and steroids after heart transplantation (HTX) are rarely published. Therefore, we collected long-term follow-up data of an intervention cohort 10 years after randomization. Ten-year follow-up data of 60 patients included in a prospective, randomized trial between 1998 and 2000 were analyzed as intention-to-treat (TAC-MMF n=30; CsA-MMF n=30). Baseline characteristics were well balanced. Cardiac allograft vasculopathy (CAV) was graduated in accordance with the new ISHLT classification. Survival at 1, 5, and 10 years was 96.7%, 80.0%, and 66.7% for TAC-MMF and 90.0%, 83.3%, and 80.0% for CsA-MMF (P=ns). Freedom from acute rejection (AR) was significantly higher in TAC-MMF versus CsA-MMF (65.5% vs. 21.7%, log-rank 8.3, P=0.004). Freedom from ISHLT≥CAV1 after 5 and 10 years was in TAC-MMF 64.0% and 45.8%, and in CsA-MMF 36.0% (log-rank 3.0, P=0.085) and 8.0% (log-rank 9.0, P=0.003). No difference in long-term results for freedom from coronary angioplasty or stenting, renal dysfunction, diabetes mellitus, CMV infection, or malignancy was detected. Cross-over effects because of treatment switch may result in impairment of significance between the groups. The long-term analysis resulted in a significant difference in manifestation of CAV between the groups after 10 years. Less rejection in the TAC-group might have contributed to the lower incidence of CAV. Superior freedom from AR and CAV in the TAC-MMF group did not result in better long-term survival.

  14. Liver fibrosis regression and progression during controlled hepatitis B virus infection among HIV–HBV patients treated with tenofovir disoproxil fumarate in France: a prospective cohort study

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    Anders Boyd

    2017-01-01

    Conclusions: Liver fibrosis levels are stable for most coinfected patients undergoing TDF, despite control of HBV replication. Nevertheless, a concerning amount of liver fibrosis progression did occur, which could be partly explained by metabolic abnormalities and past severe immunosuppression and requires further evaluation.

  15. A ten-year global record of absorbing aerosols above clouds from OMI's near-UV observations

    Science.gov (United States)

    Jethva, Hiren; Torrres, Omar; Ahn, Changwoo

    2016-05-01

    Aerosol-cloud interaction continues to be one of the leading uncertain components of climate models, primarily due to the lack of an adequate knowledge of the complex microphysical and radiative processes associated with the aerosolcloud system. The situations when aerosols and clouds are found in the same atmospheric column, for instance, when light-absorbing aerosols such as biomass burning generated carbonaceous particles or wind-blown dust overlay low-level cloud decks, are commonly found over several regional of the world. Contrary to the cloud-free scenario over dark surface, for which aerosols are known to produce a net cooling effect (negative radiative forcing) on climate, the overlapping situation of absorbing aerosols over cloud can potentially exert a significant level of atmospheric absorption and produces a positive radiative forcing at top-of-atmosphere. The magnitude of direct radiative effects of aerosols above cloud depends directly on the aerosol loading, microphysical-optical properties of the aerosol layer and the underlying cloud deck, and geometric cloud fraction. We help in addressing this problem by introducing a novel product of optical depth of absorbing aerosols above clouds retrieved from near-UV observations made by the Ozone Monitoring Instrument (OMI) on board NASA's Aura platform. The presence of absorbing aerosols above cloud reduces the upwelling radiation reflected by cloud and produces a strong `color ratio' effect in the near-UV region, which can be unambiguously detected in the OMI measurements. Physically based on this effect, the OMACA algorithm retrieves the optical depths of aerosols and clouds simultaneously under a prescribed state of atmosphere. The algorithm architecture and results from a ten-year global record including global climatology of frequency of occurrence and above-cloud aerosol optical depth, and a discussion on related future field campaigns are presented.

  16. Ten-Year Monitored Natural Recovery of Lead-Contaminated Mine Tailing in Klity Creek, Kanchanaburi Province, Thailand

    Science.gov (United States)

    Phenrat, Tanapon; Otwong, Ashijya; Chantharit, Aphichart; Lowry, Gregory V.

    2016-01-01

    Background: Klity Creek has become Thailand’s first official remediation ordered by the court in 2013, 15 years after the spill of lead (Pb)-contaminated mine tailing into the creek. The Pollution Control Department (PCD) decided to restore the creek through monitored natural recovery (MNR) since 2006 but has not been successful. Interestingly, the most recent remediation plan in 2015 will still apply MNR to five out of the seven portions of the creek, despite no scientific feasibility evaluation of using MNR to restore the creek. Objective: This study qualitatively and quantitatively evaluated the feasibility of using MNR to clean up the creek in order to protect the Klity children from excess Pb exposure. Methods: We analyzed the physical and chemical transformation of Pb contaminated sediment in the creek and developed a remedial action goal and cleanup level using the Integrated Exposure Uptake Biokinetic model (IEUBK). We empirically determined the natural recovery (NR) potentials and rates using 10 years of data monitoring the water and sediment samples from eight monitoring stations (KC1 to KC8). Results: Klity Creek has NR potential for water except at KC2, which is closest to the spill and the other improperly managed Pb sources. However, the creek has no NR potential for sediment except at the KC8 location (NR rate = 11.1 ± 3.0 × 10–3 month–1) farthest from the spill. Conclusion: The MNR method is not suitable to use as the sole remedial approach for Klity Creek (KC2 to KC7). Although MNR is applicable at KC8, it may require up to 377 ± 76 years to restore the sediment to the background Pb concentration. Citation: Phenrat T, Otwong A, Chantharit A, Lowry GV. 2016. Ten-year monitored natural recovery of lead-contaminated mine tailing in Klity Creek, Kanchanaburi Province, Thailand. Environ Health Perspect 124:1511–1520; http://dx.doi.org/10.1289/EHP215 PMID:27157823

  17. [Ten years experience with the first approved biosimilar recombinant human growth hormone drug in normal clinical practice].

    Science.gov (United States)

    López-Siguero, Juan Pedro; Palla García, Margarida; Martínez Busto, Elena; Rebollo, Francisco José; Pombo, Manuel

    2017-06-28

    Recombinant human growth hormone (rhGH) is the first biosimilar drug approved by the European Medicines Agency in 2006, using the biosimilar registration process. It was authorised for the treatment of growth hormone deficiency, and growth disorders associated with Turner's syndrome, chronic renal failure, Prader-Willi syndrome, and growth disorders in children/adolescents born small for gestational age, and replacement therapy in adults with pronounced growth hormone deficiency. This review is focused on the scientific evidence published about this drug in the last ten years, including the clinical trials on which the approval of the regulatory authority is based, and the most relevant studies evaluating the clinical impact of the drug in clinical practice. The equivalence between biosimilar and original product has been confirmed in the clinical trials published by Romer et al. and López-Siguero et al. Furthermore, studies carried out in real-life conditions confirm its long-term efficacy and safety, as well as the absence of clinical impact by switching treatment from the original to the biosimilar product. The number of patients receiving this medication has continuously increased since its approval. Its equivalence with the original product has been verified. Preliminary data from the post-authorisation PATRO study confirm the efficacy and safety of the biosimilar product in comparison with data from clinical trials. However, final results must be evaluated at the end of the study, which will provide additional information about the long-term efficacy and safety of the biosimilar drug. Copyright © 2017. Publicado por Elsevier España, S.L.U.

  18. Favourable outcome after peripartum cardiomyopathy: a ten-year study on peripartum cardiomyopathy in a university hospital.

    Science.gov (United States)

    Chee, Kok-Han

    2013-01-01

    Peripartum cardiomyopathy (PPCM) is an uncommon form of congestive heart failure, affecting obstetric patients around the time of delivery. The epidemiology of PPCM is infrequently reported. This study was undertaken to define the prevalence, presentation and outcome of PPCM among women giving birth in a teaching hospital in Malaysia. A retrospective case record analysis was conducted on all patients admitted and diagnosed with PPCM at the University Malaya Medical Centre, Kuala Lumpur, Malaysia, from 1 January 2000 to 31 December 2009. All deliveries were undertaken in the same hospital. A total of 12 patients were diagnosed with PPCM during the ten-year study period. The prevalence of PPCM was 2.48 in 100,000 (1 in 40,322) live births. Nine women were diagnosed with PPCM within five months of delivery. Three women had twin pregnancies. There was one death in the group (mortality rate 8.3%). The mean left ventricular ejection fraction at the time of diagnosis was 28.9% ± 8.5% (range 15%-40%). Following the index event, left ventricular function normalised in six of the nine patients (66.7%) who underwent subsequent echocardiography one year later. All patients were treated with standard heart failure therapy. Two patients with normalised left ventricular function had subsequent pregnancies - one pregnancy was terminated at seven weeks and the other patient delivered uneventfully at full term. PPCM is uncommon. The outcome in our series was favourable, with 66.7% of patients with PPCM recovering their left ventricular function. The mortality rate was 8.3%.

  19. Ten-year study of species distribution and antifungal susceptibilities of Candida bloodstream isolates at a Brazilian tertiary hospital.

    Science.gov (United States)

    Bonfietti, L X; Szeszs, M W; Chang, M R; Martins, M A; Pukinskas, S R B S; Nunes, M O; Pereira, G H; Paniago, A M M; Purisco, S U; Melhem, M S C

    2012-12-01

    To describe the incidence and susceptibility profile of Candida bloodstream infections in a tertiary-care hospital, we performed a retrospective observational study from 1998 to 2007. Comorbidities and risk factors were compiled from all cases. In vitro susceptibility testing to fluconazole, itraconazole, voriconazole, and amphotericin B was performed for 100 isolates, and caspofungin was tested for C. parapsilosis complex. In a ten-year evaluation of candidemias, 44 % were caused by C. albicans, and species of the C. parapsilosis complex were the second most frequent agents (37 %). Other species presented lower incidences (C. tropicalis, 13 %, C. glabrata, 5 %, and C. krusei, 1 %). Neither C. dubliniensis nor C. metapsilosis were observed in this study. C. orthopsilosis (3 %) and C. parapsilosis stricto sensu (34 %) were also found. Species distribution was independent of catheterization, mechanical ventilation, or previous use of antifungals or corticoids. Parenteral nutrition administration was strongly related to C. glabrata infection, and the highest mortality (80 %) was observed in patients infected by this species. All C. albicans isolates showed high susceptibility to all tested drugs. However, two C. parapsilosis stricto sensu isolates presented high minimum inhibitory concentration (MIC) (4 mg/L each) to fluconazole, and one exhibited voriconazole MIC of 0.25 mg/L, highlighting the cross-resistance to these azoles. All isolates of C. tropicalis and C. glabrata showed no resistance to any drug tested. No difference was noted between C. parapsilosis and C. orthopsilosis susceptibilities to caspofungin. Our results suggest that resistance to amphotericin B, fluconazole, voriconazole, itraconazole, and caspofungin in Brazilian Candida bloodstream isolates is still uncommon.

  20. Who requests their sperm donor's identity? The first ten years of information releases to adults with open-identity donors.

    Science.gov (United States)

    Scheib, Joanna E; Ruby, Alice; Benward, Jean

    2017-02-01

    To report findings from 10 years of requests from adults eligible to obtain their open-identity sperm donor's information. Analysis of archived family and donor data. Semistructured interviews at information releases. Not applicable. A total of 85 DI adults requesting 43 donor identities; program data on 256 DI families. None. We identified [1] demographic predictors of requesting donor identities, [2] information release timing and length, and [3] request motives. Just >35% of eligible DI adults requested their donor's identity. Adults ranged from 18-27 years, requesting at median age 18 years. More women than men requested. Proportionally fewer adults requested when they had heterosexual-couple parents, and proportionally more when they had one rather than two parents. In interviews, the common theme was wanting to know more about the donor, especially about shared characteristics. Most adults planned to contact their donor. More than 94% of adults had donors who were open to contact; adults expressed modest expectations about this contact. In 2001, the first adults became eligible to obtain their open-identity sperm donor's information. Ten years of identity requests at one program indicates that information about one's donor is important to a significant proportion of these DI adults. Most requested their donor's identity soon after becoming eligible, suggesting some urgency to wanting the information. Interview data highlighted the role of donor information in helping adults better understand themselves and their ancestry. Findings hold important implications for practice and policy. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  1. Clinical presentation and treatment outcome of molar pregnancy: Ten years experience at a Tertiary Care Hospital in Dammam, Saudi Arabia

    Directory of Open Access Journals (Sweden)

    Ayman A Al-Talib

    2016-01-01

    Full Text Available Objectives: To study the clinical presentation and treatment outcome of molar pregnancy at a Tertiary Care Hospital in Dammam, Saudi Arabia. Materials and Methods: Reviewed medical records of all molar pregnancy cases among all the deliveries at a tertiary care hospital in Dammam from 2005 to 2014, after approval by institutional ethical review committee. Data abstracted included patient′s age, parity, presenting symptoms, gestational age at diagnosis, uterine size, ultrasonographic findings, BhCG level at the time of diagnosis and at follow-up after evacuation, and blood loss during evacuation. Data was entered and analyzed using Excel; frequency distribution for categorical variables and descriptive statistics for continuous variables were computed. Results: Of a total of 25,000 deliveries in ten years, 22 cases of complete molar pregnancy were encountered: 0.9 cases of molar pregnancy per 1000 pregnancies. Majority of patients (63.7% were older than 35 years, and were nulliparous (45.5%. The commonest symptom was vaginal bleeding (86.4% followed by hyperemesis gravidarum (41.0%; Hyperthyroidism was seen in 1 patient (4.5%. Ovarian enlargement by theca-lutin cyst was seen in 3 patients (13.6%. The majority of patients (63.6% had normal BhCG within 9 weeks (63 days after suction curettage. The majority of the cases followed a benign course. Conclusion: Aged older than 35 years seems a risk factor and vaginal bleeding is the commonest presenting symptom. Early booking of pregnant women to antenatal care clinics and routine first trimester ultrasound made diagnosis easier and earlier before complications appear.

  2. A Ten Year Descriptive Study of Adult Leukaemia at Al-Jomhori Teaching Hospital in Sana'a, Yemen

    Directory of Open Access Journals (Sweden)

    Jameel Al-Ghazaly

    2014-12-01

    Full Text Available Background: There is scarcity of data of the epidemiology of leukaemia in Arab countries including Yemen. Understanding patterns of leukaemia underpins epidemiology and can provide insight into disease etiology. The aim of this research is to determine the epidemiologic pattern of adult leukaemia in Yemen. Methods: The research is a descriptive cross-sectional study. We analyzed the data of 702 adult patients with leukaemia, who were newly diagnosed over a ten-year period between October 1999 and October 2009 at the referral haematology centre in Sana’a at Al-Jomhori Teaching Hospital, according to type of leukaemia, age, sex, geographic distribution and time of diagnosis. Results: Acute Myeloid Leukaemia (AML was found to be the most common (45.1% followed by Chronic Myeloid Leukaemia (CML (26.5%, Acute Lymphoid Leukaemia (ALL (17.7% and Chronic Lymphoid Leukaemia (CLL (10.7%, respectively. There was an almost equal prevalence of AML and CML for males and females but males had significantly more cases of ALL and CLL (p =0.008. A significant variation in geographic pattern showed that the highest number of cases is seen the Central mountainous region and the least number of cases in the South-eastern region which is coastal and lowland (p<0.001. The seasonal variation showed that higher number of ALL cases was seen in the summer months (33% compared with other seasons (21% in the spring, 24.2% in autumn and 21.8% in winter. Conclusions: The pattern of adult leukaemia in Yemen is different from that seen in western countries which could be attributed to different environmental exposure. The geographic pattern indicates a possible role of certain environmental factors which warrant further investigations. The pattern of seasonal variation needs further studies for evaluating the seasonality.

  3. Clinical presentation and treatment outcome of molar pregnancy: Ten years experience at a Tertiary Care Hospital in Dammam, Saudi Arabia

    Science.gov (United States)

    Al-Talib, Ayman A.

    2016-01-01

    Objectives: To study the clinical presentation and treatment outcome of molar pregnancy at a Tertiary Care Hospital in Dammam, Saudi Arabia. Materials and Methods: Reviewed medical records of all molar pregnancy cases among all the deliveries at a tertiary care hospital in Dammam from 2005 to 2014, after approval by institutional ethical review committee. Data abstracted included patient's age, parity, presenting symptoms, gestational age at diagnosis, uterine size, ultrasonographic findings, BhCG level at the time of diagnosis and at follow-up after evacuation, and blood loss during evacuation. Data was entered and analyzed using Excel; frequency distribution for categorical variables and descriptive statistics for continuous variables were computed. Results: Of a total of 25,000 deliveries in ten years, 22 cases of complete molar pregnancy were encountered: 0.9 cases of molar pregnancy per 1000 pregnancies. Majority of patients (63.7%) were older than 35 years, and were nulliparous (45.5%). The commonest symptom was vaginal bleeding (86.4%) followed by hyperemesis gravidarum (41.0%); Hyperthyroidism was seen in 1 patient (4.5%). Ovarian enlargement by theca-lutin cyst was seen in 3 patients (13.6%). The majority of patients (63.6%) had normal BhCG within 9 weeks (63 days) after suction curettage. The majority of the cases followed a benign course. Conclusion: Aged older than 35 years seems a risk factor and vaginal bleeding is the commonest presenting symptom. Early booking of pregnant women to antenatal care clinics and routine first trimester ultrasound made diagnosis easier and earlier before complications appear. PMID:27625583

  4. MRC chronic Dyspnea Scale: Relationships with cardiopulmonary exercise testing and 6-minute walk test in idiopathic pulmonary fibrosis patients: a prospective study

    Directory of Open Access Journals (Sweden)

    Roussos Charis

    2010-05-01

    Full Text Available Abstract Background Exertional dyspnea is the most prominent and disabling feature in idiopathic pulmonary fibrosis (IPF. The Medical Research Chronic (MRC chronic dyspnea score as well as physiological measurements obtained during cardiopulmonary exercise testing (CPET and the 6-minute walk test (6MWT are shown to provide information on the severity and survival of disease. Methods We prospectively recruited IPF patients and examined the relationship between the MRC score and either CPET or 6MWT parameters known to reflect physiologic derangements limiting exercise capacity in IPF patients Results Twenty-five patients with IPF were included in the study. Significant correlations were found between the MRC score and the distance (r = -.781, p 2 at the initiation and the end (r = -.542, p = 0.005 and r = -.713, p VO2 peak/kg (r = -.731, p 2 at peak exercise (r = -. 682, p 2 slope (r = .731, p 2 at AT (r = .630, p = 0.002 and the Borg scale at peak exercise (r = .50, p = 0.01 for the CPET. In multiple logistic regression analysis, the only variable independently related to the MRC is the distance walked at the 6MWT. Conclusion In this population of IPF patients a good correlation was found between the MRC chronic dyspnoea score and physiological parameters obtained during maximal and submaximal exercise testing known to reflect ventilatory impairment and exercise limitation as well as disease severity and survival. This finding is described for the first time in the literature in this group of patients as far as we know and could explain why a simple chronic dyspnea score provides reliable prognostic information on IPF.

  5. Ten years of health workforce planning in the Netherlands: a tentative evaluation of GP planning as an example

    Directory of Open Access Journals (Sweden)

    Van Greuningen Malou

    2012-08-01

    Full Text Available Abstract Introduction In many countries, health-care labour markets are constantly being challenged by an alternation of shortage and oversupply. Avoiding these cyclic variations is a major challenge. In the Netherlands, a workforce planning model has been used in health care for ten years. Case description Since 1970, the Dutch government has explored different approaches to determine the inflow in medical schools. In 2000, a simulation model for health workforce planning was developed to estimate the required and available capacity of health professionals in the Netherlands. In this paper, this model is explained, using the Dutch general practitioners as an example. After the different steps in the model are clarified, it is shown how elements can be added to arrive at different versions of the model, or ‘scenarios’. A comparison is made of the results of different scenarios for different years. In addition, the subsequent stakeholder decision-making process is considered. Discussion and evaluation Discussion of this paper shows that workforce planning in the Netherlands is a complex modelling task, which is sensitive to different developments influencing the balance between supply and demand. It seems plausible that workforce planning has resulted in a balance between supply and demand of general practitioners. Still, it remains important that the modelling process is accepted by the different stakeholders. Besides calculating the balance between supply and demand, there needs to be an agreement between the stakeholders to implement the advised training inflow. The Dutch simulation model was evaluated using six criteria to be met by models suitable for policy objectives. This model meets these criteria, as it is a comprehensive and parsimonious model that can include all relevant factors. Conclusion Over the last decade, health workforce planning in the Netherlands has become an accepted instrument for calculating the required supply of

  6. What do you want to be in ten years? - Advising meteorology students in the post-Twister era

    Science.gov (United States)

    Snow, J. T.; Hempe, M.

    2012-12-01

    "What do you want to be in ten years?' This is a question we ask our students, freshmen and transfer, when they first arrive in the College student services center. Often the answer is "I don't know. I just want to be in meteorology." This response leads to a discussion of career opportunities in meteorology and related fields, including what might be called faux-careers, such as professional storm chasing and weather tour operations. (Students often have been misled by what they have seen in television shows.) Many students arrive on our doorstep with their heart set on a degree in meteorology, but lack knowledge of what the field is about or how challenging a meteorology degree program really is. We find ourselves spending a great deal of time convincing students that they need to explore the real opportunities in meteorology and related fields, which are many. Fortunately, because of the concentration of University and federal weather organizations in the National Weather Center and private sector weather companies in adjacent buildings, we are able to show concrete examples of real careers by means of tours, job shadowing, and introductions to alumni employed in these organizations. Also, as the students' progress in their studies, they discover the many opportunities for undergraduate employment, research experiences, and internships in these same organizations, through which they gain an appreciation for what constitutes a real career in modern meteorology. Further, many of today's careers in meteorology require a broad, global perspective. Unfortunately, many meteorology students have not traveled widely, but again have only seen what the media provides about distant lands and peoples. Accordingly, we encourage our undergraduate students to take advantage of our unique opportunities for overseas experiences in meteorology. Through arrangements with the met programs at the University of Reading (England), Monash University (Australia), and University of

  7. Spatial distribution and temporal variation of aerosol optical depth in the Sichuan basin, China, the recent ten years

    Science.gov (United States)

    Liu, Xinyu; Chen, Quanliang; Che, Huizheng; Zhang, Renjian; Gui, Ke; Zhang, Huan; Zhao, Tianliang

    2016-12-01

    The applicability of the MODIS (Moderate Resolution Imaging Spectroradiometer) aerosol optical depth (AOD) product was verified using CE-318 sun photometric data for the Sichuan area. The results show that MODIS_3K AOD agrees well with the AOD derived from the CE-318 sun photometer, with a high correlation coefficient (R2 = 0.91). And we used the MODIS AOD product analyzed the spatial distribution and temporal variation of the annual, seasonal and monthly distribution of AOD in the Sichuan area over the last ten years (2006-2015). In the Sichuan area, the mean change of AOD over the 10-year period showed a significant decreasing trend, reaching its maximum in 2010 and its minimum in 2015. Considering only the first five years, the lowest value was reached in 2008 and the overall trend was a standard symmetrical "V" type. Over the later five years, the annual average AOD value showed an overall decreasing trend. The monthly averaged AOD indicated a "double peaks" fluctuation trend; the two peaks appeared in March and August, and AOD changes were relatively small between September and January. Overall, the average value of AOD reached its highest values in spring, and its lowest values in autumn. In the city of Chengdu, the monthly and seasonal changes in the trend were essentially the same as those of the whole Sichuan area; However, the Chengdu AOD monthly and seasonal average change rate was higher than that of Sichuan as a whole. This shows that Chengdu is still the main contributor to the enhanced AOD value for the entire Sichuan region. The spatial distribution of AOD values indicates an "east high, west low" situation across the Sichuan area and Chengdu is one of three cities with the highest AOD values. However, the spatial variation of AOD trend value indicated an "east low, west high" the spatial distribution across the Sichuan region, opposite to the spatial distribution. Moreover, in the past 10 years, the overall AOD changes in Sichuan showed a downward

  8. Patient Reported Outcomes and Revision Rates at a Mean Follow-up of Ten Years After Lumbar Total Disc Replacement

    DEFF Research Database (Denmark)

    Laugesen, Line A.; Tendal Paulsen, Rune; Carreon, Leah

    2017-01-01

    STUDY DESIGN.: Prospective observational cohort study. OBJECTIVE.: To determine the long-term clinical results and prosthesis survival in patients treated with lumbar total disc replacement (TDR). SUMMARY OF BACKGROUND DATA.: Fusion has become the current standard surgical treatment for lumbar de...

  9. Patterns and predictors of sitting time over ten years in a large population-based Canadian sample: Findings from the Canadian Multicentre Osteoporosis Study (CaMos

    Directory of Open Access Journals (Sweden)

    Klaus Gebel

    2017-03-01

    Full Text Available Our objective was to describe patterns and predictors of sedentary behavior (sitting time over 10 years among a large Canadian cohort. Data are from the Canadian Multicentre Osteoporosis Study, a prospective study of women and men randomly selected from the general population. Respondents reported socio-demographics, lifestyle behaviors and health outcomes in interviewer-administered questionnaires; weight and height were measured. Baseline data were collected between 1995 and 1997 (n = 9418; participation rate = 42%, and at 5- (n = 7648 and 10-year follow-ups (n = 5567. Total sitting time was summed across domain-specific questions at three time points and dichotomized into “low” (≤7 h/day and “high” (>7 h/day, based on recent meta-analytic evidence on time sitting and all-cause mortality. Ten-year sitting patterns were classified as “consistently high”, “consistently low”, “increased”, “decreased”, and “mixed”. Predictors of sedentary behavior patterns were explored using chi-square tests, ANOVA and logistic regression. At baseline (mean age = 62.1 years ± 13.4 average sitting was 6.9 h/day; it was 7.0 at 5- and 10-year follow-ups (p for trend = 0.12. Overall 23% reported consistently high sitting time, 22% consistently low sitting, 14% decreased sitting, 17% increased sitting with 24% mixed patterns. Consistently high sitters were more likely to be men, university educated, full-time employed, obese, and to report consistently low physical activity levels. This is one of the first population-based studies to explore patterns of sedentary behavior (multi-domain sitting within men and women over years. Risk classification of sitting among many adults changed during follow-up. Thus, studies of sitting and health would benefit from multiple measures of sitting over time.

  10. The Essence of European Citizenship Emerging from the Last Ten Years of Academic Debate : Beyond the Cherry Blossoms and the Moon?

    NARCIS (Netherlands)

    Kochenov, D.

    2013-01-01

    This article scrutinizes the last ten years of the academic debate on EU citizenship law taking nine fundamental disagreements among scholars as starting points. It explores EU citizenship's relationship with three groups of issues of fundamental importance, including the place of this concept withi

  11. Let Book Joy Begin @ Your Library[R]!: Ten Years of El Dia de los Ninos/El Dia de los Libros

    Science.gov (United States)

    Roy, Loriene

    2007-01-01

    Ten years ago, in 1996, poet and children's book author, Pat Mora began celebrating "book joy" by founding a children's book and reading day, El Dia de los Ninos/El Dia de los Libros or Children's Day/Book Day. Dia is modeled on National Children's Day Celebrations in Mexico held since 1925 when it was launched in conjunction with a…

  12. OYSTER POPULATUION ESTIMATION IN SUPPORT OF THE TEN-YEAR GOAL FOR OYSTER RESOTRATION IN THE CHESAPEAKE BAY: DEVELOPING STRATEGIES FOR RESTORING AND MANAGING THE EASTERN OYSTER

    Science.gov (United States)

    Mann, Roger, Steve Jordan, Gary Smith, Kennedy Paynter, James Wesson, Mary Christman, Jessica Vanisko, Juliana Harding, Kelly Greenhawk and Melissa Southworth. 2003. Oyster Population Estimation in Support of the Ten-Year Goal for Oyster Restoration in the Chesapeake Bay: Develop...

  13. Fathers' and mothers' attachment representations as predictors of preadolescents' attachment security: A ten-year follow-up of Finnish families

    NARCIS (Netherlands)

    Kouvo, A.M.; Voeten, M.J.M.; Silvén, M.

    2015-01-01

    The question of how mothers' and fathers' representations of attachment correlate ten years later with children's perceptions of attachment relationships was examined in a longitudinal study on Finnish families (N = 42). The parents completed the Adult Attachment Interview (AAI) during the child's f

  14. The ten-year course of depression in primary care and long-term effects of psychoeducation, psychiatric consultation and cognitive behavioral therapy

    NARCIS (Netherlands)

    Conradi, Henk Jan; Bos, Elisabeth H; Kamphuis, Jan H; de Jonge, Peter

    BACKGROUND: While the majority of depressed patients are treated in primary care, long-term follow-up data on the naturalistic course of depression and treatment effectiveness in this setting are scarce. This study examined the ten-year course of depression in primary care patients who had

  15. Let Book Joy Begin @ Your Library[R]!: Ten Years of El Dia de los Ninos/El Dia de los Libros

    Science.gov (United States)

    Roy, Loriene

    2007-01-01

    Ten years ago, in 1996, poet and children's book author, Pat Mora began celebrating "book joy" by founding a children's book and reading day, El Dia de los Ninos/El Dia de los Libros or Children's Day/Book Day. Dia is modeled on National Children's Day Celebrations in Mexico held since 1925 when it was launched in conjunction with a…

  16. Let Book Joy Begin @ Your Library[R]!: Ten Years of El Dia de los Ninos/El Dia de los Libros

    Science.gov (United States)

    Roy, Loriene

    2007-01-01

    Ten years ago, in 1996, poet and children's book author, Pat Mora began celebrating "book joy" by founding a children's book and reading day, El Dia de los Ninos/El Dia de los Libros or Children's Day/Book Day. Dia is modeled on National Children's Day Celebrations in Mexico held since 1925 when it was launched in conjunction with a World…

  17. Students' Constitutional Right to a Sound Basic Education: New York State's Unfinished Agenda. Part 1. A Roadmap to Constitutional Compliance Ten Years after "CFE v. State"

    Science.gov (United States)

    Rebell, Michael A.; Wolff, Jessica R.

    2016-01-01

    Ten years have passed since New York's highest court ruled in the landmark school-funding and educational-rights case, "Campaign for Fiscal Equity (CFE) v. State of New York," that the state was violating students' constitutional right to the "opportunity for a sound basic education" and ordered significant reforms of the…

  18. Factors associated with severe malaria among children below ten years in Mutasa and Nyanga districts, Zimbabwe, 2014-2015.

    Science.gov (United States)

    Mutsigiri-Murewanhema, Faith; Mafaune, Patron Trish; Shambira, Gerald; Juru, Tsitsi; Bangure, Donewell; Mungati, More; Gombe, Notion Tafara; Tshimanga, Mufuta

    2017-01-01

    Severe malaria is a rare life threatening illness. Only a small proportion of patients with clinical malaria progress to this medical emergency. On reviewing 61 malaria death investigation forms submitted to the provincial office in 2014, 22(36%) were children below ten years who succumbed to severe malaria. Mutasa and Nyanga Districts reported 73% of these deaths. This study was conducted to determine factors associated with severe malaria so as to come up with evidence based interventions to prevent severe malaria and associated mortality. A 1:2 unmatched case control study was conducted. A case was defined as a child 10 years and below, who was admitted at Hauna (Mutasa) or Nyanga District Hospitals between September 2014 and May 2015 with a primary diagnosis of severe malaria. Controls were children of similar age with uncomplicated malaria. Permission to conduct the study was sought and granted by the Medical Research Council of Zimbabwe (Approval number B/874), Joint Research Ethics Committee, Health Studies Office and the Manicaland Directorate Institutional Review Board. Written informed consent was sought from all caregivers of enrolled children. Interviewer administered questionnaires were used to ascertain exposures. A total of 52 cases and 104 controls were enrolled into the study. The median age of cases was 4 years (Q1=3, Q3=9) and 6 years for controls (Q1=3, Q3=8). The Case Fatality Rate among cases was 28.8%. The independent risk factors for severe malaria were; distance >10km to the nearest health facility [Adjusted Odds Ratio (aOR)=14.35, 95% CI=1.30, 158.81], duration of symptoms before seeking medical care >2 days [aOR=9.03, 95% CI=2.21, 36.93], having comorbidities [aOR=5.38, 95% CI=1.90, 15.19], staying in a house under construction [aOR=4.51, 95%CI=1.80, 11.32] and duration of illness before receiving antimalarial medicines >24 hours [aOR=3.82, 95% CI=1.44, 10.12]. Owning at least one ITN in the household [aOR=0.32, 95% CI=0.11, 0.95] and

  19. Retrospection on the Development of China Unicom in Ten Years%中国联通:波澜壮阔十年路

    Institute of Scientific and Technical Information of China (English)

    竞辉

    2004-01-01

    China United Telecommunications Corporation welcomes its tenth anniversary on July 19,2004. After ten years' development, China Unicom has changed from a fresh enterprise into the main participator and competitor in China telecom market. Apart from getting the outstanding achievement,China Unicom also conduces to the reform and development of China telecom industry. For China Unicom, the last ten years are the right period of adopting new technologies to improve productivity,regulating corporate governance structure to establish modern enterprise system, innovating telecom services to improve the service level, and trying to break telecom monopoly to promote the market competition. Despite the furious competition in telecom market, its total asset increases from 1.34 billion yuan in beginning to 205 billion yuan, and the number of its mobile phone users has exceeded 100 million. Now China Unicom has become a comprehensive telecom enterprise run according to modern enterprise system and international criterion.

  20. Mid-term results of third-generation alumina-on-alumina ceramic bearings in cementless total hip arthroplasty: a ten-year minimum follow-up.

    Science.gov (United States)

    Yeung, Eric; Bott, Paul Thornton; Chana, Rishi; Jackson, Mark P; Holloway, Ian; Walter, William L; Zicat, Bernard A; Walter, William K

    2012-01-18

    Alumina ceramic-on-ceramic bearings have gained popularity in hip arthroplasty because of their properties of low wear and chemical inertness. In a previous study, we reported the excellent clinical results in a series of cementless ceramic-on-ceramic primary total hip arthroplasties at a minimum of five years of follow-up. The purpose of the present study was to determine the results in the same patient cohort at a minimum of ten years of follow-up. A series of 301 consecutive primary cementless total hip arthroplasties was assessed clinically and radiographically. Clinical information was available for 244 hips in 227 surviving patients at a minimum of ten years of follow-up, and radiographic information was available for 184 hips in 172 patients. Twenty-six (9.2%) of the patients had died of an unrelated cause and eight (2.7%) had undergone revision arthroplasty by the time of the latest follow-up. The average Harris hip score was 94 points, with 95% (232) of the patients having an excellent or good result and psoas tendinitis, and a repeat revision in one of the patients with psoas tendinitis due to acetabular osteolysis. The overall survival rate of the implants was 98% (95% confidence interval, 94.2% to 99.6%) at ten years with revision for any reason as the end point. The patients in our series had a good implant survival rate, good function, a low implant wear rate as reported in the previous study, and no further radiographic evidence of failure at ten years after cementless primary total hip arthroplasty with alumina ceramic-on-ceramic bearings.

  1. Long-term effects of a ten-year osteoporosis intervention program in a Swedish population—A cross-sectional study

    OpenAIRE

    Grahn Kronhed, Ann-Charlotte; Salminen, Helena

    2017-01-01

    The aim of the study was to explore long-term effects seven years after the completion of a ten-year community-based osteoporosis intervention program in Vadstena, Sweden. The association between calcaneal bone mineral density and several life style factors, and the impact of risk factors for sustaining a fracture after the age of 50 were also studied. Previous participants in the intervention group, and matched subjects were invited to calcaneal bone mass measurement by a portable device inc...

  2. DNA barcoding of life: a classification of uses according to function and scale after ten years of development

    Directory of Open Access Journals (Sweden)

    Nancai Pei

    2013-09-01

    Full Text Available DNA barcoding technology provides molecular information, standard dataset platforms, and universal technical regulations for modern biological research. We briefly review the history of DNA barcoding between 2003 and 2012, and classify DNA barcoding into three types of biological function: basic function (e.g., storing data, and identifying species, extending function (e.g., building phylogenies, serving specific subjects, and compiling biological atlas and potential function (e.g., revealing cryptic species. We sort DNA barcoding studies at three levels: clade scale (e.g., familial and/or generic taxa, community scale (e.g., biotic communities in nature reserves and permanent forest dynamics plots, and regional scale (e.g., biodiversity hotpots. We further list ten major research programs proposed by the International Barcode of Life, which are related to DNA barcoding approaches from the prospective of systematics and taxonomy, biodiversity conservation, evolutionary ecology and phylogenetics, and the construction of digital platforms. We appreciate the huge capability of barcoding technology in the field of biological sciences, and also realize the challenges of DNA barcoding utilizations in multidisciplinary studies and the essential to add more tests before the large-scale applications.

  3. RNA extraction from ten year old formalin-fixed paraffin-embedded breast cancer samples: a comparison of column purification and magnetic bead-based technologies

    Directory of Open Access Journals (Sweden)

    Zhang Haiyu

    2007-12-01

    Full Text Available Abstract Background The development of protocols for RNA extraction from paraffin-embedded samples facilitates gene expression studies on archival samples with known clinical outcome. Older samples are particularly valuable because they are associated with longer clinical follow up. RNA extracted from formalin-fixed paraffin-embedded (FFPE tissue is problematic due to chemical modifications and continued degradation over time. We compared quantity and quality of RNA extracted by four different protocols from 14 ten year old and 14 recently archived (three to ten months old FFPE breast cancer tissues. Using three spin column purification-based protocols and one magnetic bead-based protocol, total RNA was extracted in triplicate, generating 336 RNA extraction experiments. RNA fragment size was assayed by reverse transcription-polymerase chain reaction (RT-PCR for the housekeeping gene glucose-6-phosphate dehydrogenase (G6PD, testing primer sets designed to target RNA fragment sizes of 67 bp, 151 bp, and 242 bp. Results Biologically useful RNA (minimum RNA integrity number, RIN, 1.4 was extracted in at least one of three attempts of each protocol in 86–100% of older and 100% of recently archived ("months old" samples. Short RNA fragments up to 151 bp were assayable by RT-PCR for G6PD in all ten year old and months old tissues tested, but none of the ten year old and only 43% of months old samples showed amplification if the targeted fragment was 242 bp. Conclusion All protocols extracted RNA from ten year old FFPE samples with a minimum RIN of 1.4. Gene expression of G6PD could be measured in all samples, old and recent, using RT-PCR primers designed for RNA fragments up to 151 bp. RNA quality from ten year old FFPE samples was similar to that extracted from months old samples, but quantity and success rate were generally higher for the months old group. We preferred the magnetic bead-based protocol because of its speed and higher quantity of

  4. Fibrosis retroperitoneal

    Directory of Open Access Journals (Sweden)

    Claudio Orlich-Castelán

    2005-07-01

    Full Text Available Se reporta el caso de una mujer de 61 años de edad, con antecedente de tuberculosis pélvica en la adolescencia, que se presentó con insuficiencia renal aguda y dolor lumbar y a quien se le diagnosticó fibrosis retroperitoneal. Se revisa la bibliografía reciente y los principales aspectos de esta enfermedadRetroperitoneal fibrosis. is an uncommon disease complicated by ureteral entrapment causing hydronephrosis and obstructive renal failure. We herein report a case recently diagnosed at our institution and review the literature on this topic

  5. Weight variation in users of depot-medroxyprogesterone acetate, the levonorgestrel-releasing intrauterine system and a copper intrauterine device for up to ten years of use.

    Science.gov (United States)

    Modesto, Waleska; de Nazaré Silva dos Santos, Priscila; Correia, Vinicius Machado; Borges, Luiza; Bahamondes, Luis

    2015-02-01

    Data on record regarding weight variation in depot-medroxyprogesterone acetate (DMPA) and levonorgestrel-releasing intrauterine system (LNG-IUS) users are controversial. To date, no studies have yet evaluated weight variation in DMPA and LNG-IUS users in up to ten years of use compared to non-hormonal contraceptive users. A retrospective study analysed weight variations in 2138 women using uninterruptedly DMPA (150 mg intramuscularly, three-monthly; n = 714), the LNG-IUS (n = 701) or a copper-intrauterine device (Cu-IUD; n = 723). At the end of the first year of use, there was a mean weight increase of 1.3 kg, 0.7 kg and 0.2 kg among the DMPA-, LNG-IUS- and Cu-IUD users, respectively, compared to weight at baseline (p < 0.0001). After ten years of use, the mean weight had risen by 6.6 kg, 4.0 and 4.9 kg among the DMPA-, LNG-IUS- and Cu-IUD users, respectively. DMPA-users had gained more weight than LNG-IUS- (p = 0.0197) and than Cu-IUD users (p = 0.0294), with the latter two groups not differing significantly from each other in this respect (p = 0.5532). Users of hormonal and non-hormonal contraceptive methods gained a significant amount of weight over the years. DMPA users gained more weight over the treatment period of up to ten years than women fitted with either a LNG-IUS or a Cu-IUD.

  6. 近十年少儿武术研究综述%A Literature Review of Children Wushu in Recent Ten Years

    Institute of Scientific and Technical Information of China (English)

    吴飞龙

    2015-01-01

    The article uses the methods of documentary, logical analysis and data statistics, searches papers about children Wushu published in www.cnki.net.cn from 2005 to 2014, reviews the number of paper and characteristics of children Wushu research in the last ten years, and finds the research field of children Wushu in recent ten years. It finds out that the number of thesis studying children Wushu in recent ten years are relatively few, the research methods are too simple, the depth of research content is relatively narrow,and the research content is relatively narrow. The search focuses on the promotion of children Wushu. To this end, we hope that the research can effectively inspire experts and scholars' interest and attention in order to promote the development of children Wushu.%文章运用文献资料法,逻辑分析法以及数据统计法,以2005—2014年为时间段,检索发表在中文期刊全文数据库少儿武术研究的文献资料,回顾近十年少儿武术科研论文发表的数量、特点以及少儿武术的研究领域等方面内容,并从中发现近十年少儿武术研究的成果相对较少、研究方法过于单一、研究内容的深度较浅、研究领域相对狭隘。文章着眼于大力推广少儿武术,以期有效地引起广泛的专家及学者的兴趣和注意,促进和推动少儿武术的发展。

  7. Disaster exposure as a risk factor for mental health problems, eighteen months, four and ten years post-disaster--a longitudinal study.

    Science.gov (United States)

    van den Berg, Bellis; Wong, Albert; van der Velden, Peter G; Boshuizen, Hendriek C; Grievink, Linda

    2012-09-18

    Disaster experiences have been associated with higher prevalence rates of (mental) health problems. The objective of this study was to examine the independent relation between a series of single disaster experiences versus the independent predictive value of a accumulation of disaster experiences, i.e. a sum score of experiences and symptoms of distress and post-traumatic stress disorder (PTSD). Survivors of a fireworks disaster participated in a longitudinal study and completed a questionnaire three weeks (wave 1), eighteen months (wave 2) and four years post-disaster (wave 3). Ten years post-disaster (wave 4) the respondents consisted of native Dutch survivors only. Main outcome measures were general distress and symptoms of PTSD. Degree of disaster exposure (sum score) and some disaster-related experiences (such as house destroyed, injured, confusion) were related to distress at waves 2 and 3. This relation was mediated by distress at an earlier point in time. None of the individual disaster-related experiences was independently related to symptoms of distress. The association between the degree of disaster exposure and symptoms of PTSD at waves 2 and 3 was still statistically significant after controlling for symptoms of distress and PTSD at earlier point in time. The variable 'house destroyed' was the only factor that was independently related to symptoms of PTSD at wave 2. Ten years after the disaster, disaster exposure was mediated by symptoms of PTSD at waves 2 and 3. Disaster exposure was not independently related to symptoms of PTSD ten years post-disaster. Until 4 years after the disaster, degree of exposure (a sum score) was a risk factor for PTSD symptoms while none of the individual disaster experiences could be identified as an independent risk factor. Ten years post-disaster, disaster exposure was no longer an independent risk factor for symptoms of PTSD. Since symptoms of PTSD and distress at earlier waves perpetuate the symptoms at later waves

  8. Preparing Science-Trained Professionals for the Biotechnology Industry: A Ten-Year Perspective on a Professional Science Master’s Program

    Directory of Open Access Journals (Sweden)

    Paul T. Hamilton

    2012-02-01

    Full Text Available The biotechnology industry has a need for business-savvy scientists; however, this is not the way scientists are traditionally trained at universities and colleges. To address this need, universities have developed Professional Science Master’s (PSM degree programs that offer advanced training in a technical field along with professional skills development through team-based projects and internships. Nearly ten years ago, the Department of Microbiology at NCSU started a PSM program in Microbial Biotechnology (MMB. This article provides an overview of the MMB program, and shares some of the lessons that we have learned.

  9. Evaluación de la fibrosis hepática en la hepatitis crónica por virus C mediante la aplicación prospectiva del Sabadell's NIHCED score: Sabadell's Non Invasive, Hepatitis C Related-Cirrhosis Early Detection Score Prospective evaluation of liver fibrosis in chronic viral hepatitis C infection using the Sabadell NIHCED: non-invasive hepatitis C related cirrhosis early detection index

    Directory of Open Access Journals (Sweden)

    G. Bejarano

    2009-05-01

    of fibrosis grade is liver biopsy. Our group validated a predictive index - NIHCED - based on demographic, laboratory parameters, and echoghraphic data to determine the presence of cirrhosis. Objective: our objective is to evaluate whether the NIHCED score predicts the presence of advanced fibrosis in patients with chronic HCV infection. Material and methods: this prospective study included patients with chronic HCV infection who underwent liver biopsy and were administered the NIHCED score. Fibrosis grade correlated with the NIHCED score using the ROC curve analysis and Spearman's correlation coefficient. Results: in total 321 patients were included (male/female ratio 1.27 with a mean age of 48 ± 14 years. Liver biopsy showed that 131 (30.5% had no fibrosis or had portal expansion while 190 (69.5% had advanced fibrosis or cirrhosis. At a cut-off point of 6, sensitivity was 72%, specificity was 76.3%, positive predictive value (PPV was 81%, negative predictive value (NPV was 63.7%, and diagnostic accuracy was 72.5%, with an area under the curve (AUC of 0.787, and a Spearman's correlation coefficient of r = 0.65. Conclusions: the NIHCED score predicts the presence of advanced fibrosis in an elevated percentage of patients with a need of liver biopsy.

  10. Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis

    National Research Council Canada - National Science Library

    Weidemann, Frank; Herrmann, Sebastian; Störk, Stefan; Niemann, Markus; Frantz, Stefan; Lange, Volkmar; Beer, Meinrad; Gattenlöhner, Stefan; Voelker, Wolfram; Ertl, Georg; Strotmann, Jörg M

    2009-01-01

    In this prospective follow-up study, the effect of myocardial fibrosis on myocardial performance in symptomatic severe aortic stenosis was investigated, and the impact of fibrosis on clinical outcome...

  11. Trends in the theoretical and research methodological approaches applied in doctoral studies in information and knowledge management: an exploration of ten years of research in South Africa

    Directory of Open Access Journals (Sweden)

    M. A. Mearns

    2008-01-01

    Full Text Available The past ten years have seen the field of information and knowledge management develop and implement new and improved technologies. Because of the ease with which information is exchanged the contribution to information overload has increased exponentially and the need for information and knowledge management is more real than ever before. Research in itself is a science of knowledge creation that continuously evolves in line with newly developed theories and research methodologies. An investigation of the theories and research methodologies that doctoral theses, completed in South Africa, ascribed to over the past ten years were conducted. Search strings containing 'information management', 'knowledge management' and 'information and knowledge management' were searched within citation, abstract and subject fields. A sample of 30 theses from a possible 47 in the relevant population was identified. Qualitative and mixed methods research design was favoured, making use of case studies and surveys, but paying little attention to theoretical approaches or paradigms. The boundaries between disciplines are continuously re-defined, new disciplines evolve and traditional disciplines suffer under the pressures of changing problems of the world. The importance of research in the field of information and knowledge management being grounded in the most recent scientific thought is emphasized.

  12. Study of enzyme replacement therapy for Gaucher Disease: comparative analysis of clinical and laboratory parameters at diagnosis and after two, five and ten years of treatment

    Directory of Open Access Journals (Sweden)

    Ana Maria Almeida Souza

    2014-10-01

    Full Text Available Objective: To evaluate the impact of enzyme replacement therapy for Gaucher Disease on clinical and laboratory parameters after two, five and ten years of treatment. Methods: Data were collected from patient records and analyzed using BioEstat software (version 5.0. Student's t-test, Analysis of Variance (ANOVA, Wilcoxon test and Kruskal–Wallis test were used for statistical analysis. Hepatomegaly and splenomegaly were analyzed using the Kappa test. Results: There was a significant increase in hemoglobin levels (p-value <0.01 and platelet counts (p-value = 0.01 within two years of therapy. At the same time, the frequencies of splenomegaly (p-value <0.01 and hepatomegaly (p-value <0.05 reduced. These results were similar at five and ten years of enzyme replacement therapy. Conclusions: There are substantial and quick (within two years laboratory and clinical responses to enzyme replacement therapy. These improvements continue as long as enzyme replacement therapy is administered every two weeks, as recommended by the literature.

  13. Trends in the theoretical and research methodological approaches applied in doctoral studies in information and knowledge management: an exploration of ten years of research in South Africa

    Directory of Open Access Journals (Sweden)

    M. A. Mearns

    2008-01-01

    Full Text Available The past ten years have seen the field of information and knowledge management develop and implement new and improved technologies. Because of the ease with which information is exchanged the contribution to information overload has increased exponentially and the need for information and knowledge management is more real than ever before. Research in itself is a science of knowledge creation that continuously evolves in line with newly developed theories and research methodologies. An investigation of the theories and research methodologies that doctoral theses, completed in South Africa, ascribed to over the past ten years were conducted. Search strings containing 'information management', 'knowledge management' and 'information and knowledge management' were searched within citation, abstract and subject fields. A sample of 30 theses from a possible 47 in the relevant population was identified. Qualitative and mixed methods research design was favoured, making use of case studies and surveys, but paying little attention to theoretical approaches or paradigms. The boundaries between disciplines are continuously re-defined, new disciplines evolve and traditional disciplines suffer under the pressures of changing problems of the world. The importance of research in the field of information and knowledge management being grounded in the most recent scientific thought is emphasized.

  14. Review and prospect about idiopathic pulmonary fibrosis%特发性肺间质纤维化的回顾和展望

    Institute of Scientific and Technical Information of China (English)

    崔社怀

    2010-01-01

    自50多年前Hamman和Rich报道4例死于原因不明的弥漫性肺间质纤维化以来,特发性肺间质纤维化(idiopathic pulmonary fibrosis,IPF)的概念和定义有了突飞猛进的发展,尤其是近5年, 这反映了广大的科研和临床工作者对此类疾病的重视和不断探索.

  15. Fibrosis retroperitoneal

    Directory of Open Access Journals (Sweden)

    Claudio Orlich-Castelán

    2005-07-01

    Full Text Available Se reporta el caso de una mujer de 61 años de edad, con antecedente de tuberculosis pélvica en la adolescencia, que se presentó con insuficiencia renal aguda y dolor lumbar y a quien se le diagnosticó fibrosis retroperitoneal. Se revisa la bibliografía reciente y los principales aspectos de esta enfermedad

  16. [Retroperitoneal fibrosis].

    Science.gov (United States)

    Babski, Paweł; Wojtuń, Stanisław; Gil, Jerzy

    2007-05-01

    Retroperitoneal fibrosis is a rare clinical entity characterised by the presence of patologic collagen tissue in a retroperitoneal space. The fibrous mass covers abdominal organs causing their disfunctions. RPF was described at the begining of XX century but its etiology is not clear yet. Usually it causes an ureter obstuction and hydronephrosis, that is why most commonly is diagnosed by urologists and nephrologists. However, retroperitoneal fibrosis can be multifacial disease. In some patients localisation of fibrosis is atypical and manifestationns can be varied. Gastrological symptoms like jaundice, bowel obstuction, ascites can occure. Besides, some early signs of RPF are nonspecific and can imitate alarming symptoms of neoplasma, e.g.: weight loss, anemia, malaise, anorexia, fever. This force us to initiate gastrological investigation. The awareness of this disease is important. The early diagnosis and treatment improves prognosis and alows to avoid heavy complications. In typical cases radiology is often enough for diagnosis. However, histological examination is needed in many cases, especialy when patological mass is located atypical. A treatment is made up of farmacology and surgery. The first one is based on steroids, immunossuppressant and tamoxifen. Surgery is needed to eliminate organs obstruction.

  17. 中国少数民族公民教育10年研究综述%Review of the Ten-year Citizen Education of Chinese Ethnic Minorities

    Institute of Scientific and Technical Information of China (English)

    耿亚军; 王颖

    2012-01-01

    This article reviews the citizen education of ethnic minorities in the past ten years from the perspectives of research origin,research status and research prospect.It is stated that the citizen education of ethnic minorities can be strengthened by reinforcing theory construction,coordinating theory and practice with social demand and closely combining internationalization and localization in order to formulate a citizen education system of ethnic minority with Chinese characteristics.%从研究缘起、研究现状、研究展望三方面对少数民族公民教育10年来的情况进行了综述。认为应通过加强理论构建、理论和实践与社会需要相协调、国际化和本土化紧密结合等方面加强少数民族公民教育,以形成有中国特色的少数民族公民教育体系。

  18. Ten years of archival science

    NARCIS (Netherlands)

    Ketelaar, E.

    2010-01-01

    This article reviews how the journal Archival Science--International Journal on Recorded Information in the first 10 years has endeavoured to be integrated, interdisciplinary, and intercultural in promoting the development of archival science as an autonomous scientific discipline.

  19. Ten years of archival science

    NARCIS (Netherlands)

    E. Ketelaar

    2010-01-01

    This article reviews how the journal Archival Science--International Journal on Recorded Information in the first 10 years has endeavoured to be integrated, interdisciplinary, and intercultural in promoting the development of archival science as an autonomous scientific discipline.

  20. To Be Ten Years Younger

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    EAT Bananas Often—Bananas are rich in vitamins A, B, C, E, and many mineral substances like iron and phosphorus that help to balance the acidity and alkalinity of your body. It is one of the best health foods to refresh you and ease your mind. Drink Milk Everyday—Milk contains high levels of calcium and is very nutritious. Drinking a cup of milk helps you to absorb 3 grams more protein. The drink does good to

  1. Phototroph genomics ten years on.

    Science.gov (United States)

    Raymond, Jason; Swingley, Wesley D

    2008-07-01

    The onset of the genome era means different things to different people, but it is clear that this new age brings with it paradigm shifts that will forever affect biological research. Less clear is just how these shifts are changing the scope and scale of research. Are gigabases of raw data more useful than a single well-understood gene? Do we really need a full genome to understand the physiology of a single organism? The photosynthetic field is poised at the periphery of the bulk of genome sequencing work--understandably skewed toward health-related disciplines--and, as such, is subject to different motivations, limitations, and primary focus for each new genome. To understand some of these differences, we focus here on various indicators of the impact that genomics has had on the photosynthetic community, now a full decade since the publication of the first photosynthetic genome. Many useful indicators are indexed in public databases, providing pre- and post-genome sequence snapshots of changes in factors such as publication rate, number of proteins characterized, and sequenced genome coverage versus known diversity. As more genomes are sequenced and metagenomic projects begin to pour out billions of bases, it becomes crucial to understand how to harness this data in order to accumulate possible benefits and avoid possible pitfalls, especially as resources become increasingly directed toward natural environments governed by photosynthetic activity, ranging from hot springs to tropical forest ecosystems to the open ocean.

  2. Cystic Fibrosis Research

    Science.gov (United States)

    ... please turn Javascript on. Feature: Steady Advances Against Cystic Fibrosis Cystic Fibrosis Research Past Issues / Fall 2012 Table of Contents "Remarkable strides in cystic fibrosis research over the past two decades have culminated ...

  3. Idaho National Laboratory Ten-year Site Plan (2012 through 2021) -- DOE-NE's National Nuclear Capability -- Developing and Maintaining the INL Infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Cal Ozaki

    2010-06-01

    To meet long-term objectives to transform the Idaho National Laboratory (INL), we are providing an integrated, long-term vision of infrastructure requirements that support research, development and demonstration (RD&D) goals outlined in the DOE strategic plans, including the NE Roadmap and reports such as Facilities for the Future of Nuclear Energy Research: A Twenty-year Outlook. The goal of the INL Ten-year Site Plan (TYSP) is to clearly link RD&D mission goals and INL core capabilities with infrastructure requirements (single and multi-program), establish the 10-year end-state vision for INL complexes, identify and prioritize infrastructure and capability gaps, as well as the most efficient and economic approaches to closing those gaps.

  4. Durability of the reaction to fire performance for fire retardant treated (FRT wood products in exterior applications – a ten years report

    Directory of Open Access Journals (Sweden)

    Östman Birgit

    2016-01-01

    Full Text Available Several long term experimental studies on the maintained reaction to fire performance of fire retardant treated (FRT wood products over time are presented. They are performed according to a European system based on earlier Nordic and North American systems and include accelerated ageing according to different procedures and natural weathering up to ten years. Main conclusions are: The hygroscopic properties are unchanged compared to untreated wood for most FRT wood products used commercially. The reaction to fire properties of FRT wood may be maintained after accelerated and natural ageing if the retention levels are high enough, but several FRT wood products loose most of their improved reaction to fire properties during weathering. Paint systems contribute considerably to maintain of the fire performance at exterior application and are usually needed to maintain the fire performance after weathering.

  5. Endovascular treatment of false-aneurysm ten years after dacron patch aortoplasty for coarctation of the aortic isthmus. Report of a case.

    Science.gov (United States)

    Illuminati, Giulio; Pacilè, Maria Antonietta; Palumbo, Piergaspare; Salvatori, Filippo Maria; Vietri, Francesco

    2013-01-01

    False aneurysm degeneration is a known complication of patch aortoplasty for coarctation of the aortic isthmus. Open surgical treatment consists of prosthetic graft repair of the involved aorta, often requires circulatory arrest to achieve a safe proximal aortic control and perform proximal anastomosis, and finally is associated with substantial perioperative morbidity. Endografting of the diseased aorta is a valuable alternative to open repair, when feasible, with good short and long term results. We now report one more case of false aneurysm ten years after Dacron patch aortoplasty for isthmic coarctation in a 26-year-old woman, successfully treated by endovascular repair via the left common iliac artery, and a complete exclusion of the aneurysm at two year follow-up.

  6. Advancing the education in molecular diagnostics: the IFCC-Initiative "Clinical Molecular Biology Curriculum" (C-CMBC); a ten-year experience.

    Science.gov (United States)

    Lianidou, Evi; Ahmad-Nejad, Parviz; Ferreira-Gonzalez, Andrea; Izuhara, Kenji; Cremonesi, Laura; Schroeder, Maria-Eugenia; Richter, Karin; Ferrari, Maurizio; Neumaier, Michael

    2014-09-25

    Molecular techniques are becoming commonplace in the diagnostic laboratory. Their applications influence all major phases of laboratory medicine including predisposition/genetic risk, primary diagnosis, therapy stratification and prognosis. Readily available laboratory hardware and wetware (i.e. consumables and reagents) foster rapid dissemination to countries that are just establishing molecular testing programs. Appropriate skill levels extending beyond the technical procedure are required for analytical and diagnostic proficiency that is mandatory in molecular genetic testing. An international committee (C-CMBC) of the International Federation for Clinical Chemistry (IFCC) was established to disseminate skills in molecular genetic testing in member countries embarking on the respective techniques. We report the ten-year experience with different teaching and workshop formats for beginners in molecular diagnostics.

  7. Comparison of the impacts of climate change and anthropogenic disturbances on the El Arish coast and seaweed vegetation after ten years in 2010, North Sinai, Egypt

    Directory of Open Access Journals (Sweden)

    Gihan Ahmed El Shoubaky

    2013-08-01

    Full Text Available Human activities on coasts and climate changes during the past ten years have given rise to considerable shoreline changes along the El Arish coast (the northern coast of the Sinai Peninsula. In the El Arish Power Plant, sediment accretion has reached the tip of the breakwaterof the cooling water intake basin, necessitating extensive dredging inside the basin. To the east of El Arish Harbour, the shoreline has been incontinuous retreat. The differences between the year 2000 and 2010 in the shoreline along the El Arish coast weredetermined by analysing satellite images from NOAA-AVHRR images. The analyses revealed erosion and accretionpatterns along the coast. The physical parameters showed that the minimum water temperature of 18°C wasrecorded at site I in winter and that the maximum was 40°C at site II in summer. The latter temperature can be attributed to the effluent dischargeof cooling water from the El Arish power plant. Spatial and temporal patterns in the distribution and abundance of macroalgae were measured at four sites(I, II, III and IV along the El Arish coast. The percentage cover of the successional macroalgae exhibited environmental fluctuations. After ten years,the phytocommunity showed that red and green algae were dominant at the study sites. Significant differences between past and current flora were observed.39 taxa recorded in 2000 were absent in 2010, while 9 taxa not previously reported were present in 2010. These changes are discussed in the context ofpossible global warming effects.PERMANOVA showed significant changes (p < 0.001 between sites, seasons, species abundance and macroalgal groups along the El Arish coast in 2000 and2010. The similarity matrix showed a significant difference between the flora in 2010 and that recorded in 2000, indicating poor similarity and changes inspecies composition among the seasons at the different sites. Most of the algae belonged to the filamentous, coarsely branched and sheet

  8. Ten-year chemical signatures associated with long-range transport observed in the free troposphere over the central North Atlantic

    Directory of Open Access Journals (Sweden)

    B. Zhang

    2017-03-01

    Full Text Available Ten-year observations of trace gases at Pico Mountain Observatory (PMO, a free troposphere site in the central North Atlantic, were classified by transport patterns using the Lagrangian particle dispersion model, FLEXPART. The classification enabled identifying trace gas mixing ratios associated with background air and long- range transport of continental emissions, which were defined as chemical signatures. Comparison between the chemical signatures revealed the impacts of natural and anthropogenic sources, as well as chemical and physical processes during long transport, on air composition in the remote North Atlantic. Transport of North American anthropogenic emissions (NA-Anthro and summertime wildfire plumes (Fire significantly enhanced CO and O3 at PMO. Summertime CO enhancements caused by NA-Anthro were found to have been decreasing by a rate of 0.67 ± 0.60 ppbv/year in the ten-year period, due possibly to reduction of emissions in North America. Downward mixing from the upper troposphere and stratosphere due to the persistent Azores-Bermuda anticyclone causes enhanced O3 and nitrogen oxides. The 'd' [O3]/'d' [CO] value was used to investigate O3 sources and chemistry in different transport patterns. The transport pattern affected by Fire had the lowest 'd' [O3]/'d' [CO], which was likely due to intense CO production and depressed O3 production in wildfire plumes. Slightly enhanced O3 and 'd' [O3]/'d' [CO] were found in the background air, suggesting that weak downward mixing from the upper troposphere is common at PMO. Enhancements of both butane isomers were found during upslope flow periods, indicating contributions from local sources. The consistent ratio of butane isomers associated with the background air and NA-anthro implies no clear difference in the oxidation rates of the butane isomers during long transport. Based on observed relationships between non-methane hydrocarbons, the averaged photochemical age of the air masses at

  9. Clinical evaluation of the role of tulsi and turmeric in the management of oral submucous fibrosis: A pilot, prospective observational study

    Directory of Open Access Journals (Sweden)

    Adit Srivastava

    2015-01-01

    Full Text Available The aim of the present study was to investigate the clinical efficacy of herbal medicines (1 gm tulsi and 1 gm turmeric mixed in glycerine base for the treatment of oral submucous fibrosis (OSMF. Forty-one patients in the age group of 17- 56 years without any systemic complications were included in the study. The patients were treated with medicines, which were to be applied 3-4 times a day. Blood samples were collected before and after treatment to screen for any systemic changes due to these medications. Burning sensation and mouth opening were recorded before and after treatment. Patients were followed up on monthly subsequent visits for three months. Changes in the burning sensation on visual analogue scale (VAS scale and difference in the mouth opening were analyzed statistically. A statistically significant improvement was seen in both burning sensation and mouth opening. Tulsi and turmeric offers a safe and efficacious combination of natural products available for symptomatic treatment of OSMF.

  10. Biomarkers for liver fibrosis

    Science.gov (United States)

    Jacobs, Jon M.; Burnum-Johnson, Kristin E.; Baker, Erin M.; Smith, Richard D.; Gritsenko, Marina A.; Orton, Daniel

    2015-09-15

    Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.

  11. Biomarkers for liver fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Jacobs, Jon M.; Burnum-Johnson, Kristin E.; Baker, Erin M.; Smith, Richard D.; Gritsenko, Marina A.; Orton, Daniel

    2017-05-16

    Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.

  12. Mortality, recruitment and growth of the tree communities in three forest formations at the Panga Ecological Station over ten years (1997-2007

    Directory of Open Access Journals (Sweden)

    Ana Paula de Oliveira

    2014-06-01

    Full Text Available The area evaluated in this study was a continuous stretch comprising three vegetation formations: gallery forest, semideciduous seasonal forest and cerradão (woodland savanna. The aim of this study was to examine the tree community dynamics in a forest gradient-from gallery forest to cerradão-at Panga Ecological Station, in the city of Uberlandia, located in the state of Minas Gerais, Brazil. The study was based on data from a previous inventory of the continuous forest conducted in 211 permanent 10 × 10 m sample plots in eight parallel transect running perpendicular to Panga Creek. Trees with a diameter at breast height > 4.77 cm were sampled in 1997, 2002 and 2007. With the exception of the cerradão, there was a net reduction in tree density over the studied period of ten years, because mortality rates were higher than the recruitment rates. The basal area increased during the period of the study, especially at cerradão. The mean mortality rate in the studied area was 2.64%.yr-1 and 3.36%.yr-1 for the 1997-2002 and 2002-2007 periods, respectively, whereas the mean recruitment rate was 1.76%.yr-1 and 1.97%.yr-1, respectively. In general, mortality rates and recruitment rates have increased during the two successive periods of measurement and showed an imbalance in favor of mortality for the semideciduous seasonal forest and the gallery forest. This fact, added to the low density and high basal area, suggest that there was a process of thinning in the tree community. However, at cerradão, there was an imbalance in favor of recruitment, with a consequent increase in density and basal area, indicating that the cerradão is in a construction phase, which was further favored by a decrease in the occurrence of fire and other anthropogenic disturbances. When the turnover rates are taken into consideration, the global dynamics of the study area over the ten years evaluated can be expressed as cerradão > semideciduous seasonal forest > gallery

  13. Model-based iterative reconstruction in pediatric chest CT: assessment of image quality in a prospective study of children with cystic fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Mieville, Frederic A.; Bochud, Francois O.; Verdun, Francis R. [Lausanne University Hospital, Institute of Radiation Physics, Lausanne (Switzerland); Berteloot, Laureline; Brunelle, Francis [Necker Children' s Hospital of Paris and University of Paris Descartes, Department of Pediatric Radiology, Paris (France); Grandjean, Albane; Ayestaran, Paul [General Electric Medical Systems Europe, Paris (France); Gudinchet, Francois; Schmidt, Sabine [Lausanne University Hospital, Department of Radiology, Lausanne (Switzerland)

    2013-03-15

    The potential effects of ionizing radiation are of particular concern in children. The model-based iterative reconstruction VEO trademark is a technique commercialized to improve image quality and reduce noise compared with the filtered back-projection (FBP) method. To evaluate the potential of VEO trademark on diagnostic image quality and dose reduction in pediatric chest CT examinations. Twenty children (mean 11.4 years) with cystic fibrosis underwent either a standard CT or a moderately reduced-dose CT plus a minimum-dose CT performed at 100 kVp. Reduced-dose CT examinations consisted of two consecutive acquisitions: one moderately reduced-dose CT with increased noise index (NI = 70) and one minimum-dose CT at CTDI{sub vol} 0.14 mGy. Standard CTs were reconstructed using the FBP method while low-dose CTs were reconstructed using FBP and VEO. Two senior radiologists evaluated diagnostic image quality independently by scoring anatomical structures using a four-point scale (1 = excellent, 2 = clear, 3 = diminished, 4 = non-diagnostic). Standard deviation (SD) and signal-to-noise ratio (SNR) were also computed. At moderately reduced doses, VEO images had significantly lower SD (P < 0.001) and higher SNR (P < 0.05) in comparison to filtered back-projection images. Further improvements were obtained at minimum-dose CT. The best diagnostic image quality was obtained with VEO at minimum-dose CT for the small structures (subpleural vessels and lung fissures) (P < 0.001). The potential for dose reduction was dependent on the diagnostic task because of the modification of the image texture produced by this reconstruction. At minimum-dose CT, VEO enables important dose reduction depending on the clinical indication and makes visible certain small structures that were not perceptible with filtered back-projection. (orig.)

  14. Bacteriological profile of community acquired acute bacterial meningitis: A ten-year retrospective study in a tertiary neurocare centre in South India

    Directory of Open Access Journals (Sweden)

    Mani R

    2007-01-01

    Full Text Available Purpose: Ten years retrospective study to evaluate the bacteriological spectrum of community acquired acute bacterial meningitis (CAABM. Methods: Cerebrospinal fluid (CSF samples from 385 clinically suspected cases of pyogenic meningitis were processed for cell counts, cytospin Gram stain, culture, antigen detection by latex agglutination (LAT and antibiotic susceptibility test. Eighteen of these CSF samples were also subjected to a polymerase chain reaction (PCR assay for detection of pneumococcal DNA. Results: The etiological agent could be identified in 284 (73.8% of the total 385 cases by culture and/or smear and /or LAT. Streptococcus pneumoniae was the predominant pathogen accounting for 238 (61.8% cases. Haemophilus influenzae and Neisseria meningitidis accounted for 7 (1.8% and 4 (1% cases respectively. Other gram negative bacilli, Streptococcus spp. and Staphylococcus aureus were isolated from 19 (4.9%, 9 (2.3% and 7 (1.8% cases respectively. Conclusions: Streptococcus pneumoniae remains the major aetiological agent of CAABM both in adults and children in our set-up. No penicillin resistance was detected among the isolates. Further research should focus on preventable aspects of CAABM, especially pneumococcal vaccines, to help reduce the disease burden.

  15. Toxic Nodularia spumigena blooms in the coastal waters of the Gulf of Gdańsk: a ten-year survey

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    Hanna Mazur-Marzec

    2006-06-01

    Full Text Available In the Baltic Sea, summer blooms of the filamentous, nitrogen-fixingcyanobacterium Nodularia spumigena are favoured by high P concentrationsat low N:P ratios and a salinity range of 5-13 PSU. The bloomsare initiated by calm and sunny weather, an elevated surfacewater temperature and thermal stratification. The mass occurrenceof N. spumigena in coastal waters is a matter of special concern,as the cyanobacterium produces nodularin, a potent pentapeptidehepatotoxin. In the Gulf of Gdansk, the large-scale occurrenceof N. spumigena was recorded for the first time in 1994. Bloomsof a similar intensity occurred in 2001, 2003 and 2004. Nodularinconcentrations in freeze-dried bloom samples varied from 0.01to 4.01 mg g-1 d.w. In the coastal waters of the Gulf of Gdańsk,cell-bound nodularin concentrations in 2004 and 2005 attainedmaxima of 25852 ± 107 µg dm-3 and3964 ± 125 µg dm-3, respectively. Microscopic analysis revealedthe presence of diverse N. spumigena forms, with the dominance of curvedfilaments in bloom samples. The results of in situ studies and remotesensing measurements indicate a high frequency and intensity of cyanobacterialblooms in the Gulf of Gdańsk in the last ten years.

  16. 近十年我国成人有效教学研究综述%An Overview of Adult Effective Teaching in Recent Ten Years

    Institute of Scientific and Technical Information of China (English)

    张蓉

    2012-01-01

    In recent ten years, the research on adult effective teaching in our country has gone through three stages: start, development and prosperity. The research mainly related to the connotation, the lack of effectiveness and the strategies of adult effective teaching. The research has made some achievements, but there are several deficiencies such as duplication, the lack of research depth, simple research methods and some other issues. This article would make induction, generalization and reflection on adult effective teaching for about the past 10 years, with a view to promoting the further study.%近十年来,我国关于"成人有效教学"的研究经历了起步、发展和繁荣三个阶段。研究内容主要涉及成人有效教学的内涵、成人教学有效性缺失及成人有效教学策略等。研究虽然取得了一定成果,但还存在着研究成果重复、研究内容缺乏深度、研究方法单一等问题。对近十年有关成人有效教学的研究成果进行梳理、概括与反思,以期促进这一研究的进一步深入。

  17. Higher percentage of in vitro apoptotic cells at time of diagnosis in patients with chronic lymphocytic leukemia indicate earlier treatment requirement: Ten years follow up

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    Kravić-Stevović Tamara

    2014-01-01

    Full Text Available Introduction. Chronic lymphocytic leukemia (CLL has an extremely variable clinical course. Biological reasons for that wide variation in clinical course and survival rates in CLL patients are not fully understood. Objective. The aim of the study was to evaluate the value of spontaneous apoptosis of CLL cells in vitro determined at presentation of disease, in prediction of treatment requirements and evolution of the CLL. Methods. Malignant B cells were isolated from the whole blood of 30 newly diagnosed CLL patients and cultured for 24 hours in RPMI-1640 medium supplemented with 10% of serum obtained from the same CLL patient. Cells were later fixed and processed for embedding in Epon, or cell smears were prepared and stained with TUNEL technique. Results. Ten-year follow-up revealed that patients with lower percentage of cells in apoptosis at presentation of disease had significant longer time treatment initiation (log rank test p0.05. Conclusion. The results of this study emphasize the importance of apoptosis of CLL cells at the time of the initial diagnosis in pathobiology of this disease. [Projekat Ministarstva nauke Republike Srbije, br. 41025

  18. A ten years follow-up of the results of surgery for Dupuytren's disease. A study of fifty-eight cases.

    Science.gov (United States)

    Norotte, G; Apoil, A; Travers, V

    1988-01-01

    Fifty-eight patients (52 males and 6 females) operated on for Dupuytren contracture were examined by the same author with a more than ten year follow-up. At time of surgery the average was 55 years old. 69 hands (169 fingers) rated 4.33 according to the simplified Tubiana's score were treated by the same operative procedure: Mac Indoe's incision, digital Z plasty (if needed), subtotal fasciectomy and physiotherapy beginning 8 days postoperatively. At long term, recurrence appears for 49 hands (71%) one every two in the two first postoperative years, one out of five after five years. 24 of them were graded stage I. The recurrence appeared 14 times associated with an extension of the disease and the earlier, the higher was the initial stage. Some factors seem to be of a bad prognosis regarding recurrence: age (93% of recurrence under 50 years old) Ledderhose or Lapeyronie (100%) other associated diseases (Alcoholism, diabetes mellitus, epilepsy) and severe preoperative stage. Subjective results are good: 45 patients are satisfied and only 3 underwent a second operation.

  19. Quality of life in the late follow-up of ulcerative colitis patients submitted to restorative proctocolectomy with sphincter preservation over ten years ago

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    Alberto Luiz Monteiro Meyer

    2009-01-01

    Full Text Available OBJECTIVE: To evaluate, by means of the Inflammatory Bowel Disease Questionnaire (IBDQ, the quality of life of ulcerative colitis patients submitted to proctocolectomy with sphincter preservation using J-pouch reconstruction over ten years ago. METHODS: The study consisted of 36 patients interviewed using the Inflammatory Bowel Disease Questionnaire. The score scale, resulting from the addition of each answer, ranged from 32 to 224, where the highest score indicates the best quality of life. The chi square test was used to verify the existence of meaningful differences between the results of the questionnaire and age, and gender proportion. For each section, as well as for all of them combined, the Kruskal-Wallis test was used to verify if there were differences in the Inflammatory Bowel Disease Questionnaire scores among the groups in relation to the proportions. RESULTS: After applying the Inflammatory Bowel Disease Questionnaire, it was determined that quality of life was considered excellent for 9 (25%, good for 11 (30.6%, regular for 13 (36.1%, and bad for 3 (8.3% patients. In our study, we determined that 85% of the patients were pleased with and thankful for the surgery that they underwent. CONCLUSION: We can conclude that the possibility of sphincter preservation should always be taken into account, since patients remain clinically stable and have a high quality of life even after long periods.

  20. Vegetation development in a sand dune ten years after restoration, Parque Municipal das Dunas da Lagoa da Conceição, Florianópolis, Santa Catarina

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    Nina Rosa Zanin Zanella

    2010-01-01

    Full Text Available The vegetation cover of a sand dune was surveyed ten years after the improvement of a restoration project that utilized seed sowing, seedling planting and seedling transplantation from an adjacent area with watering in the first months. On the upper part of the restored dune, the vegetation was sparse (53% but more developed than that of the adjacent control area (34%, both presenting herbaceous/subshrub physiognomy with predominance of Panicum racemosum. On the slope of the restored dune, a shrub vegetation developed, presenting a percentage cover (90% similar to that of the control area (100%. Dodonaea viscosa was the dominant species on this restored face. The establishment of arboreal and shrub species seedlings on the upper dune was good. In part, this improved the species richness, but contributed to dissimilarity between this area and the control site.  A lower species richness was presented on the slope and the similarity to the control area was even lower. Plants introduced by sowing and seedling transplantation showed success and contributed to the similarity with the adjacent vegetation. Seedlings of arboreal and shrub plants survived on the upper dune. These species are represented in a more developed stage of succession, differing from the adjacent control area.

  1. [Dermatophytosis due to Trichophyton rubrum. Ten-year period (1996-2006) data collection in a Dermatology Department in Mexico City].

    Science.gov (United States)

    Hernández-Salazar, Amparo; Carbajal-Pruneda, Patricia; Fernández Martínez, Ramón; Arenas, Roberto

    2007-06-01

    Dermatophytosis is the most common mycosis in the world up to 80% caused by Trichophyton rubrum. The aim of the present study was to describe the clinical characteristics of the dermatophytosis caused by T. rubrum in a dermatological outpatient clinic during a ten years period, from 1996 to 2005. We collected the data from patients with a dermatophytosis from which we have isolated T. rubrum. A total of 776 patients with dermatophytosis caused by T. rubrum were found. A slight predominance of female patients (56.2%) was observed. The most commonly affected age group was those in the third to the fifth decade of life, and house working women (33.5%) were predominant. Onychomycosis was found in 63% of the cases, tinea pedis in 22.7%, tinea corporis in 5.2% and tinea cruris in 2.8%. In onychomycosis, the first toe nail was the most commonly affected (58.9%) and the dystrophic type was seen in 50.7% of them.

  2. A Review of the Kafka Study in China in the Past Ten Years%近十年来中国卡夫卡研究述评

    Institute of Scientific and Technical Information of China (English)

    周定宇

    2001-01-01

    Chinese academic circles have made remarkable achiev ements in the Kafka study in the past ten years. The major achievements include several monogr aphs and over 140 research papers. Furthermore, Mr. Ye Ting-fang published his b ook “The Collected Works of Franz Kafka", which marked that China's Kafka study has earned a place in the world.%近10年来,中国学术界对卡夫卡的研究取得了令人可喜的成 绩。这主要表现在:几部专著先后问世;论文达140余篇,尤其值得一提的是,由叶廷芳先 生主编的《卡夫卡全集》的出版,标志着中国“卡学”在全世界开始拥有一席之地。

  3. Changes in Local People’s Perceptions of the Sumava National Park in the Czech Republic over a Ten Year Period (1998–2008

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    Martin Cihar

    2012-06-01

    Full Text Available The Sumava National Park (NP, the largest protected area of its kind in Central Europe, is as interesting as it is problematic (historical development, conflicts between regional development and landscape protection. In order to evaluate the success of the Park’s policies, local park inhabitants’ attitudes were assessed over a ten-year period. Two surveys (N = 181 and N = 200 were conducted in August, 1998 and 2008. The questionnaires consisted of 43 queries from three thematic areas; (a socio-demographic data, (b environment and nature conservation, and (c sustainable tourism and local development. The comparison of the results 1998 with 2008 showed that the Park inhabitants perceived living in the Park as improving and the scheme for nature conservation as either “optimal” or “more strict”. The surveys also showed the loss of job opportunities as the most prevalent local concern. In a cluster analysis based on perceptions of (a the Park, (b the environment and (c Park Administration, subjects were divided into four opinion groups ranging from “optimists” to “grumblers”. The most “positive (optimistic” group saw little connection between the Park’s existence and job losses, while the most “negative” group saw a strong connection in that regard.

  4. [Comparing the occurrence of Trichomonas vaginalis infections today to ten years ago among women prostitutes and gynecology and obstetrics patients in Istanbul].

    Science.gov (United States)

    Polat, Erdal; Sirekbasan, Serhat; Yıldırım, Zehra; Bağdatlı, Yaşar; Çepni, Ismail; Çift, Tayfur; Baltalı, Nezihe D

    2011-01-01

    Trichomonas vaginalis is is a monoxenous parasite which lives in human urogenital systems and causes sex transmitted disease through human sexual contact. Disease frequency has been seen at different rates in different communities or in the same community depending on people's sociocultural status. Previously we made a study for determining prevalence of T. vaginalis infection in woman living in Istanbul. We made this present study for determining any difference in prevalence in comparison to the results of ten years earlier. A total number of 207 vaginal discharge samples which were collected from two different hospitals, (93 from Venereal Diseases Hospital [VDH] and 114 from Cerrahpasa Ob&Gyn Clinic), were evaluated under direct microscopy and were cultured for T. vaginalis in a Cystein-Peptone-Liver-Maltose (CPLM) medium. T. vaginalis was observed under direct microscopy and grew in culture in 2 (0.97%) of 207 vaginal discharge samples [1 (1.1%) patient from VDH and 1 (0.9%) patient from Cerrahpasa]. The incidence of trichomoniasis has significantly decreased compared to the year 2000 in both VDH and Cerrahpasa populations (p=0.038) according to X2 test results. This epidemiologic study shows the importance of social development in the incidence of infectious diseases.

  5. Taking stock of gene therapy for cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Alton Eric WFW

    2000-09-01

    Full Text Available Abstract The identification of the cystic fibrosis (CF gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal models in vivo has been followed by numerous clinical studies using both viral and non-viral vectors to transfer normal copies of the gene to the lungs and noses of CF patients. A wealth of data have emerged from these studies, reflecting enormous progress and also helping to focus and define key difficulties that remain unresolved. Gene therapy for CF remains the most promising possibility for curative rather than symptomatic therapy.

  6. Cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Radlović Nedeljko

    2012-01-01

    Full Text Available Cystic fibrosis (CF is a multisystemic autosomal recessive disease caused by a defect in the expression of CFTR protein, i.e. chloride channel present in the apical membrane of respiratory, digestive, reproductive and sweat glands epithelium. It primarily occurs in the Caucasians, while being considerably or exceptionally rare in persons of other races. Absence, deficit or structural and functional abnormalities of CFTR protein lead to mucosal hyperconcentration in the respiratory, digestive and reproductive systems and malabsorption of chloride and sodium in the sweat glands. Thus, the clinical features of patients’ with CF are predominated by respiratory, digestive and reproductive disorders, as well as the tendency to dehydration in the condition of increased sweating. Beside genotype variations, the degree of disease manifestation is also essentially influenced by various exogenous factors, such as the frequency and severity of respiratory infections, the level of aero-pollution, quality of immunoprophylaxis, patients’ nutritional condition and other. Chloride concentration of over 60 mmol/L in sweat, a high level of immunoreactive chymotrypsinogen in blood and the verification of homozygous mutation of CFTR gene are the basic methods in the diagnostics of the disease. CF belongs to the group of severe and complex chronic diseases, and therefore requires multidisciplinary therapeutic approach. Owing to the improvement of healthcare provision, most patients with CF now survive into adulthood. In addition, their quality of life is also considerably improved.

  7. Ten Year Projections for US Residency Positions: Will There be Enough Positions to Accommodate the Growing Number of U.S. Medical School Graduates?

    Science.gov (United States)

    Hayek, Sarah; Lane, Samantha; Fluck, Marcus; Hunsinger, Marie; Blansfield, Joseph; Shabahang, Mohsen

    2017-09-14

    Recently, a multitude of new U.S. medical schools have been established and existing medical schools have expanded their enrollments. The National Residency Match Program (NRMP) reports that in 2016 there were 23,339 categorical residency positions offered in the match and 26,836 overall applicants with 17,789 (66.29%) of the total candidates being U.S. allopathic graduates. In view of the rapid growth of medical school graduates, the aim of this study is to determine if current trends suggest a shortage of residency positions within the next ten years. The total number of graduates from U.S. medical schools was obtained from the Association of American Medical Colleges (AAMC) for 2005-2014 academic years and was trended linearly for a 10-year prediction for the number of graduates. The yearly number of categorical positions filled by U.S. graduates for calendar years 2006-2015 was obtained from the NRMP and was trended longitudinally 10 years into the future. Analysis of subspecialty data focused on the comparison of differences in growth rates and potential foreseeable deficits in available categorical positions in U.S. residency programs. According to trended data from AAMC, the total number of graduates from U.S. medical schools has increased 1.52 percent annually (15,927 in 2005 to 18,705 in 2014); with a forecast of 22,280 U.S. medical school graduates in 2026. The growth rate of all categorical positions available in U.S. residency programs was 2.55 percent annually, predicting 29,880 positions available in 2026. In view of these results, an analysis of specific residencies was done to determine potential shortages in specific residencies. With 17.4 percent of all U.S. graduates matching into internal medicine and a 3.17 percent growth rate in residency positions, in 2026 the number of internal medicine residency positions will be 9,026 with 3,874 U.S. graduates predicted to match into these positions. In general surgery, residency positions note a growth

  8. Ten Years of Rainfall and Community-Based Streamflow Monitoring in the Tropical Montane Cloud Forest Region of Central Veracruz, Mexico: What Do These Data Tell Us?

    Science.gov (United States)

    Holwerda, F.; Aranda-Delgado, E.; Castilleja-Delgado, E.; Munoz-Villers, L.

    2016-12-01

    Montane ecosystems and the water resources provided by them play a crucial role in the development and growth of cities and the productive sector in Mexico. For the planning and sustainable management of these resources, it is necessary to quantify the key hydrological components and have (at least some) basic understanding of the water cycle at the operational watershed-scale. However, the difficulty of implementing and maintaining rainfall-discharge observation networks due to the lack of financial resources and well-trained personnel, coupled with poor accessibility and safety, as well as the complexity of the biophysical and climatic conditions in montane regions have hampered progress in hydrological research and the generation of basic knowledge for the benefit of society. In 2005, research-motivated measurements of rainfall (P) and community-based observations of streamflow (Q) were initiated independently in the tropical montane cloud forest (TMCF) region of central Veracruz, Mexico. In this presentation, we will explore these data to study the seasonal and annual P inputs and Q outputs of the ca. 11,000 ha Pixquiac river watershed as observed during the past ten years (2005-2015). The P data used in this analysis include continuous measurements from the major recharge zone within the study area (2000-2300 m asl), supplemented with observations from lower and higher altitudes to determine the P-elevation relationship. The Q data of the Pixquiac river consist of monthly measurements made near the outlet of the watershed (1300-1400 m asl) by citizen volunteers using the Global Water Watch methodology. We expect that these observations will contribute to an improved understanding of the hydrometeorology of mesoscale TMCF watersheds in central Veracruz, which is a prerequisite for sustainable planning and management of the water resources in this region.

  9. New Library Movement in the First Ten Years of the 21st Century%新世纪十年的新图书馆运动

    Institute of Scientific and Technical Information of China (English)

    沈占云

    2012-01-01

    In the first ten years of the 21st century,the theory research on library science in China publicizes the public library spirit,starts the new library movement,and promotes researches on library rights positively.At the same time,in the practice field,library circles carry out in-depth investigations into public libraries,organize the volunteer action positively,and train managers of primary level libraries for years.The new library movement embeds the concept of public library spirit and library rights in the library practice work,and has important significance for the development of public libraries in China.%新世纪十年,我国图书馆学理论研究宣扬公共图书馆精神,开展新图书馆运动,积极推动图书馆权利研究;同时,在实践层面,我国图书馆界深入开展基层公共图书馆调查,积极组织志愿者行动,连续多年为基层图书馆管理者开展义务培训。新图书馆运动使公共图书馆精神与图书馆权利等理念根植于我国图书馆实际工作中,对我国公共图书馆的发展具有重要的意义。

  10. Ten-Year Mortality after a Breast Cancer Diagnosis in Women with Severe Mental Illness: A Danish Population-Based Cohort Study.

    Directory of Open Access Journals (Sweden)

    Anette Riisgaard Ribe

    Full Text Available Breast cancer is the leading cause of cancer death in women worldwide. Nevertheless, it is unknown whether higher mortality after breast cancer contributes to the life-expectancy gap of 15 years in women with severe mental illness (SMI.We estimated all-cause mortality rate ratios (MRRs of women with SMI, women with breast cancer and women with both disorders compared to women with neither disorder using data from nationwide registers in Denmark for 1980-2012.The cohort included 2.7 million women, hereof 31,421 women with SMI (12,852 deaths, 104,342 with breast cancer (52,732 deaths, and 1,106 with SMI and breast cancer (656 deaths. Compared to women with neither disorder, the mortality was 118% higher for women with SMI (MRR: 2.18, 95% confidence interval (CI: 2.14-2.22, 144% higher for women with breast cancer (MRR: 2.44, 95% CI: 2.42-2.47 and 327% higher for women with SMI and breast cancer (MRR: 4.27, 95% CI: 3.98-4.57. Among women with both disorders, 15% of deaths could be attributed to interaction. In a sub-cohort of women with breast cancer, the ten-year all-cause-mortality was 59% higher after taking tumor stage into account (MRR: 1.59, 95% CI: 1.47-1.72 for women with versus without SMI.The mortality among women with SMI and breast cancer was markedly increased. More information is needed to determine which factors might explain this excess mortality, such as differences between women with and without SMI in access to diagnostics, provision of care for breast cancer or physical comorbidity, health-seeking-behavior, and adherence to treatment.

  11. BIFoR FACE: A ten-year Free-Air Carbon Dioxide Enrichment (FACE) Experiment in Old Growth Deciduous English Woodland

    Science.gov (United States)

    Thomas, R. M.; MacKenzie, A. R.; Ellsworth, D.; Hemming, D.; Crous, K.; Pope, F.; Blaen, P.; Poynter, A.; Hamilton, L.; Blenkhorn, D.; Jarvis-Rouse, F.

    2015-12-01

    The Birmingham Institute of Forest research (BIFoR) will perform fundamental physical, biological, ecological, social and cultural research of direct relevance to forested landscapes worldwide. A core platform for BIFoR to study the ten-year response of a mature temperate deciduous forest ecosystem to against a large step-change in atmospheric [CO2] is the BIFoR Free-Air Carbon Dioxide Enrichment (FACE) experiment. BIFoR FACE is being established in Mill Haft, a mature (~150 year-old) oak (Quercus robur) and hazel (Corylus avellana) coppice-with-standards woodland in central England. The facility will enable elevated CO2 (eCO2) treatments to be introduced in 30 m diameter rings (3 treatment and 6 control plots), commencing in spring 2016. Under eCO2 conditions primary research questions will investigate carbon uptake and storage, corresponding nutrient limitations, and biodiversity and ecosystem responses. As well as describing the facility and experimental design, we present baseline data collected throughout 2015, prior to fumigation. These data include: biophysical tree properties; atmospheric CO2/H2O fluxes; airborne and ground laser scatterometry; leaf area index; geophysical survey data; phenology camera derivatives; soil and water chemical and physical properties; and invertebrate surveys. Data from an intensive campaign conducted during august 2015 are also shown, including in- and above- canopy characterisation of biogenic VOCs using a Proton Transfer Reaction Mass Spectrometer, aerosol loading including bioaerosols, and enhanced atmospheric chemistry. Further campaign results are presented from leaf level photosynthetic carbon-dioxide response curve (A/Ci) performed at different canopy heights on oak trees, and on the dominant understory species - hazel and sycamore (Acer pseudoplatinus) across the site. BIFoR FACE is an exciting new international facility for forest science - ideas for collaborations are encouraged. Please see http

  12. New Effective Treatment of Liver Fibrosis by Chinese Herbal Medicine

    Institute of Scientific and Technical Information of China (English)

    张国梁

    2002-01-01

    @@ Liver fibrosis is an abnormal proliferation pathologic process of intrahepatic fibrous connective tissue that occurs after liver cells have been necrotized and stimulated by inflammatory factors. It is called fibrosis when the pathological change is mild, and liver cirrhosis when the change becomes so severe as to reconstruct the liver lobuli to form pseudolobuli and nodule(1). Liver fibrosis is an important pathological characteristic of chronic hepatopathy and the chief intermediate link to further develop of liver cirrhosis. No ideal remedy for treatment of chronic hepatitic cirrhosis has been found so far. Although some drugs, such as colchicine and penicillamine, had been reported to have the effect of fibrosis inhibition, their clinical application is still limited for the rather severe toxic-side effects. Certain progress have been made from the clinical and experimental studies on anti-fibrosis treatment by traditional Chinese medicine (TCM) carried out widely in China in recent ten years. And here is a general review of the drugs used.

  13. NEONATAL JAUNDICE – A RARE FORM OF CYSTIC FIBROSIS

    Directory of Open Access Journals (Sweden)

    Nataša Milivojevič

    2003-04-01

    Full Text Available Background. Cystic fibrosis is an autosomal recessive disorder that results in damage to organs containing secretory epithelial cells. It predominantly affects respiratory tract and pancreatic function. While hepatobiliary system is frequently affected in older children with cystic fibrosis, in neonatal period jaundice caused by cystic fibrosis is a rare condition. Two cases were identified in the last ten years (1988–98 in the Department of Pediatrics University Medical Centre Ljubljana.Patients and methods. We present two patients with neonatal jaundice as one of the rare features of cystic fibrosis. Laboratory evidences of cholestasis and liver involvement were present in both cases. In the first case, an improvement of a liver disease occured spontaneously and in the second case the resolution of clinical and laboratory evidence of liver disease followed after she had been treated with ursodeoxycholic acid.Conclusions. Neonatal jaundice and cholestasis can be caused by cystic fibrosis. The treatment is conservative with ursodeoxycholic acid. Only in the cases when the disease is not improving conservatively, the surgical procedure can be considered.

  14. Study and prospects of transforming growth factor-β induced epithelial-mesenchymal transition on pulmonary fibrosis%转化生长因子β诱导上皮细胞-间质细胞转分化与肺纤维化关系的研究现状与展望

    Institute of Scientific and Technical Information of China (English)

    陈娟; 王昌明

    2012-01-01

    Transforming growth factor β (TGF-β) plays an essential role in the process of pulmonary fibrosis.TGF-β regulates pulmonary fibrosis by stimulating and activating the high expression of collagen mRNA of fihroblasts,to promote the synthesis of extra cellular matrix and improve the stability of the collagen molecule after transcription.The latest research suggests that TGF-β induced epithelial-mesenchymal transition (EMT) may be the key mechanisms of pulmonary fibrosis.This article reviews the present condition and prospects of the association between TGF-β induced EMT and pulmonary fibrosis.%肺纤维化过程中,转化生长因子β(TGF-β)起着关键性的作用.TGF-β调节肺纤维化通过刺激、活化成纤维细胞高表达胶原mRNA从而促进细胞外基质成分的合成,同时增强胶原分子转录后稳定性.最新研究表明,TGF-β诱导的上皮细胞间质细胞转分化(EMT)可能是肺纤维化的关键机制.本文就TGF-β诱导EMT与肺纤维化关系的研究现状与展望作一综述.

  15. What Causes Cystic Fibrosis?

    Science.gov (United States)

    ... page from the NHLBI on Twitter. What Causes Cystic Fibrosis? A defect in the CFTR gene causes cystic ... in the severity of the disease. How Is Cystic Fibrosis Inherited? Every person inherits two CFTR genes—one ...

  16. Learning about Cystic Fibrosis

    Science.gov (United States)

    ... Testing for Cystic Fibrosis Consensus Development Conference Statement Learning About Cystic Fibrosis What do we know about ... and treatment information. Hosted by the Dolan DNA Learning Center at Cold Spring Harbor Laboratory. What is ...

  17. Cystic fibrosis: case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Si Hyun; Lee, Hyun Ju; Kim, Ji Hye; Park, Chol Heui [Gachon Medical School, Inchon (Korea, Republic of)

    2002-12-01

    Cystic fibrosis is an autosomal recessive genetic disease. Among Caucasians, it is the most common cause of pulmonary insufficiency during the first three decades of life. The prevalence of cystic fibrosis varies according to ethnic origin: it is common among Caucasians but rare among Asians. We report a case in which cystic fibrosis with bronchiectasis and hyperaeration was revealed by high-resolution CT, and mutation of the cystic fibrosis conductance transmembrane regulator gene (CFTR) by DNA analysis.

  18. Summary of clinic application of Xiaoyao Powder in recent ten years%逍遥散近十年的临床应用概述

    Institute of Scientific and Technical Information of China (English)

    郭艳苓

    2013-01-01

    逍遥散为调和肝脾的常用代表方剂,具有疏肝解郁、健脾和营、养血调经之功.笔者总结近十年逍遥散临床应用概况,在妇科领域有痛经、月经不调、经前期紧张综合征、乳腺病、不孕症、更年期综合征等,消化系统疾病如肠易激综合症、功能性消化不良等,内分泌系统疾病如高催乳素血症、糖尿病、甲亢性心脏病等,神经系统疾病如神经衰弱、失眠等,皮肤科的黄褐斑、痤疮等都有应用.只要辨证准确,谨守病机,都取得了理想的治疗效果,充分体现了中医异病同治的治则精髓.%Xiaoyao Powder is a representative prescription for relieving Qi stagnancy, tonifying spleen and reconciling Ying, nourishing blood for regulating tnenstruation. The author has made a summary oi the clinie application of Xiaoyao Powder in recent ten years. Fust, it is used in gynaecology for dysmen-orrhea, irregular tnenstrnation, premenstrual tension syndrome, mastosis, infertility, menopause syndrome. Second, it is suitable for irritable bowel syndrome, funrtional dyspepsia in digestive system. Third, it is suitable for hyperprolactinemia, diabetes, hyperthyroid heart disease in endocrine system. Four, it is suitable for neurosism, insomnia in nervous system. Five, it is also suitable for chloasma, acne in dermatology. This prescription has achieved a lot on the basis of accurate differentiation and cautiously grasping pathogenesis, all of which embodies the core of rules of treatment, namely , homotherapy for heter-opathy.

  19. Ten-year follow-up of percutaneous transluminal coronary angioplasty for proximal left anterior descending coronary artery stenosis in 351 patients.

    Science.gov (United States)

    Ten Berg, J M; Gin, M T; Ernst, S M; Kelder, J C; Suttorp, M J; Mast, E G; Bal, E; Plokker, H W

    1996-07-01

    We sought to evaluate the short- and long-term results of balloon angioplasty for stenoses in the proximal left anterior descending coronary artery. Both the supposedly high rate of acute complications and relatively poor long-term results of balloon angioplasty for stenoses in the proximal left anterior descending coronary artery have led to a search for alternative interventional techniques. We analyzed the success rates and long-term follow-up results in 351 consecutive patients who underwent balloon angioplasty for stenosis of the left anterior descending coronary artery proximal to its first side branch. The power of the study was >80% in detecting a difference of 9% in the proportion of patients who survived at 10 years, assuming an 80% survival rate in the control group. There were 60 ostial and 291 nonostial stenoses. Follow-up lasted a median of 85 months (range 0 to 137) and was 100% complete. The angiographic success rate was 90.9%. The clinical success rate was 86.3%. Nine patients (2.6%) died, 17 (4.8%) needed emergency coronary artery bypass graft surgery, and 10 (2.8%) developed a myocardial infarction. Several patients had subsequent complications. The success and complication rates were not significantly different for patients with ostial and nonostial stenoses. Ten years after balloon angioplasty, freedom from mortality was 80%, freedom from cardiac death was 87%, freedom from myocardial infarction was 84%, freedom from vessel-related reinterventions was 66%, and freedom from angina pectoris was 33%. There were more reinterventions for ostial stenoses, with a 1-year relative risk of ostial versus nonostial stenoses for related reinterventions of 1.7 (95% confidence interval 1 to 2.8, p = 0.049). More than 10 years ago, balloon angioplasty for stenoses in the proximal left anterior descending coronary artery, either ostial or nonostial, had a high success rate. Although the long-term results are satisfactory, ostial stenoses are associated with a

  20. [The TraumaRegister DGU® as the basis of medical quality management. Ten years experience of a national trauma centre exemplified by emergency room treatment].

    Science.gov (United States)

    Helm, M; Bitzl, A; Klinger, S; Lefering, R; Lampl, L; Kulla, M

    2013-07-01

    The trauma register of the German Society of Trauma Surgery (TraumaRegister DGU®/TR-DGU) has been proven to be a valuable tool for external assessment of quality in the treatment of patients with major trauma. This publication shows for the first time how the quality of trauma treatment in a level I trauma centre could be improved over a period of almost ten years with the help of continuous quality management, i.e. recognizing a problem, developing a solution and evaluating its effect. Tracer parameters and indicators of quality are presented in four periods over a total study period from 1st January 1989 to 31st March 2007. The division into four periods is due to major changes in the trauma treatment algorithms or structural changes in the trauma room. The results are displayed for all patients treated in the trauma room and for those patients with an injury severity score (ISS)≥16. Over all four periods a total number of n=2,239 patients were admitted to the trauma room. Based on the results of the trauma register a number of changes were made, not only structural changes, such as the introduction of point-of-care diagnostics, initially conventional X-ray, then digital X-ray and finally multislice computed tomography (CT) scanning in the trauma room but also changes in the way personnel participating in the trauma treatment are trained. Advanced trauma life support (ATLS®) has become the standard training for doctors and prehospital trauma life support (PHTLS®) for nurses. Time efficient treatment algorithms were introduced. All measures led to changes in several parameters which are chosen as indicators for good treatment quality. It was for instance possible to reduce the average total trauma treatment time for patients with an ISS≥16 from initially 90.9±48.6 min to 37.4±18.  min in the final study period. The external quality management performed by the TR-DGU has proved to be a constant source of inspiration. The effects of the changes made can

  1. Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a ten-year surveillance study (2000–2009

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    Linhares Inês

    2013-01-01

    Full Text Available Abstract Background Urinary tract infection (UTI is one of the most common infectious diseases at the community level. In order to assess the adequacy of the empirical therapy, the prevalence and the resistance pattern of the main bacteria responsible for UTI in the community (in Aveiro, Portugal was evaluated throughout a ten-year period. Methods In this retrospective study, all urine samples from patients of the District of Aveiro, in ambulatory regime, collected at the Clinical Analysis Laboratory Avelab during the period 2000–2009 were analysed. Samples with more than 105 CFU/mL bacteria were considered positive and, for these samples, the bacteria were identified and the profile of antibiotic susceptibility was characterized. Results From the 155597 samples analysed, 18797 (12.1% were positive for bacterial infection. UTI was more frequent in women (78.5% and its incidence varied with age, affecting more the elderly patients (38.6%. Although E. coli was, as usual, the most common pathogen implicated in UTI, it were observed differences related to the other bacteria more implicated in UTI relatively to previous studies. The bacteria implicated in the UTI varied with the sex of the patient, being P. aeruginosa a more important cause of infection in men than in women. The incidence of the main bacteria changed over the study period (P. aeruginosa, Klebsiella spp and Providencia spp increased and Enterobacter spp decreased. Although E. coli was responsible for more than an half of UTI, its resistance to antibiotics was low when compared with other pathogens implicated in UTI, showing also the lowest percentage of multidrug resistant (MDR isolates (17%. Bacteria isolated from females were less resistant than those isolated from males and this difference increased with the patient age. Conclusions The differences in sex and age must be taken into account at the moment of empirical prescription of antimicrobials. From the recommended

  2. Ten years of CO2, CH4, CO and N2O fluxes over Western Europe inferred from atmospheric measurements at Mace Head, Ireland

    Directory of Open Access Journals (Sweden)

    S. G. Jennings

    2008-01-01

    Full Text Available We estimated CO2, CH4, CO and N2O emission fluxes over the British Isles and Western Europe using atmospheric radon observations and concentrations recorded at the Mace Head Atmospheric Research Station between 1996 and 2005. We classified hourly concentration data into either long-range European or regional sources from Ireland and UK, by using local wind speed data in conjunction with 222Rn and 212Pb threshold criteria. This leads to the selection of about 7% of the total data for both sectors. We then used continuous 222Rn measurements and assumptions on the surface emissions of 222Rn to deduce the unknown fluxes of CO2, CH4, CO and N2O. Our results have been compared to the UNFCCC, EMEP and EDGAR statistical inventories and to inversion results for CH4. For Western Europe, we found yearly mean fluxes of 4.1±1.5 106 kg CO2 km−2 yr−1 , 11.9±2.0 103 kg CH4 km−2 yr−1, 12.8±4.2 103 kg CO km−2 yr−1 and 520.2±129.2 kg N2O km−2 yr−1, respectively, for CO2, CH4, CO and N2O over the period 1996–2005. The method based upon 222Rn to infer emissions has many sources of systematic errors, in particular its poorly known and variable footprint, uncertainties in 222Rn soil fluxes and in atmospheric mixing of air masses with background air. However, these biases are likely to remain constant in the long-term, which makes the method quite efficient to detect trends in fluxes. Over the last ten years period, the decrease of the anthropogenic CH4, CO and N2O emissions in Europe estimated by inventories (respectively −30%, −35% and −23% is confirmed by the Mace Head data within 2%. Therefore, the 222Rn method provides an independent way of verification of changes in national emissions derived from inventories. Using European-wide estimates of the CO/CO2 emission ratio, we also found that it is possible to separate the fossil fuel CO2 emissions contribution from the one of total CO2 fluxes. The fossil fuel CO2 emissions and their trends

  3. Ten-year trends of atmospheric mercury in the high Arctic compared to Canadian sub-Arctic and mid-latitude sites

    Directory of Open Access Journals (Sweden)

    A. S. Cole

    2013-02-01

    Full Text Available Global emissions of mercury continue to change at the same time as the Arctic is experiencing ongoing climatic changes. Continuous monitoring of atmospheric mercury provides important information about long-term trends in the balance between transport, chemistry, and deposition of this pollutant in the Arctic atmosphere. Ten-year records of total gaseous mercury (TGM from 2000 to 2009 were analyzed from two high Arctic sites at Alert (Nunavut, Canada and Zeppelin Station (Svalbard, Norway; one sub-Arctic site at Kuujjuarapik (Nunavik, Québec, Canada; and three temperate Canadian sites at St. Anicet (Québec, Kejimkujik (Nova Scotia and Egbert (Ontario. Five of the six sites examined showed a decreasing trend over this time period. Overall trend estimates at high latitude sites were: −0.9% yr−1 (95% confidence limits: −1.4, 0 at Alert and no trend (−0.5, +0.7 at Zeppelin Station. Faster decreases were observed at the remainder of the sites: −2.1% yr−1 (−3.1, −1.1 at Kuujjuarapik, −1.9% yr−1 (−2.1, −1.8 at St. Anicet, −1.6% yr−1 (−2.4, −1.0 at Kejimkujik and −2.2% yr−1 (−2.8, −1.7 at Egbert. Trends at the sub-Arctic and mid-latitude sites agree with reported decreases in background TGM concentration since 1996 at Mace Head, Ireland, and Cape Point, South Africa, but conflict with estimates showing an increase in global anthropogenic emissions over a similar period. Trends in TGM at the two high Arctic sites were not only less negative (or neutral overall but much more variable by season. Possible reasons for differences in seasonal and overall trends at the Arctic sites compared to those at lower latitudes are discussed, as well as implications for the Arctic mercury cycle. The first calculations of multi-year trends in reactive gaseous mercury (RGM and total particulate mercury (TPM at Alert were also performed, indicating increases from 2002 to 2009

  4. Endometriosis-associated ovarian cancer: A ten-year cohort study of women living in the Estrie Region of Quebec, Canada

    Directory of Open Access Journals (Sweden)

    Aris Aziz

    2010-01-01

    Full Text Available Abstract Objectives Endometriosis has been believed to increase the risk of developing ovarian cancer, but recent data supporting this hypothesis are lacking. The aim of this study was to verify whether the incidence of endometriosis, ovarian cancer and the both increased during the last 10 years among women living in the Estrie region of Quebec. Methods We collected data of women diagnosed with endometriosis, ovarian cancer or both, between 1997 and 2006, from a population living in the Estrie region of Quebec. We performed this retrospective cross-sectional study from the CIRESSS (Centre Informatisé de Recherche Évaluative en Services et Soins de Santé system, the database of the CHUS (Centre Hospitalier Universitaire of Sherbrooke, Sherbrooke, Canada. Results Among the 2854 identified patients, 2521 had endometriosis, 292 patients had ovarian cancer and 41 patients had both ovarian cancer and endometriosis. We showed a constant increase in the number of ovarian cancer (OC between 1997 and 2006 (r2 = 0.557, P = 0.013, which is not the case for endometriosis (ENDO or endometriosis-associated ovarian cancer (EAOC. The mean age ± SD was 40.0 ± 9.9 and 53.9 ± 11.4 for patients having ENDO and OC, respectively. Mean age of women with EAOC was 48.3 ± 10.8, suggesting an early onset of ovarian cancer in women having endometriosis of about 5.5 years average, P = 0.003. Women with ENDO were at increased risk for developing OC (Rate Ratio [RR] = 1.6; 95% Confidence Interval [CI] = 1.12-2.09. Pathological analyses showed the predominance of endometrioid type (24.4% and clear-cell type (21.9% types in EAOC compared to OC, P = 0.0070 and 0.0029, respectively. However, the serous type is the most widespread in OC (44.5% in comparison to EAOC (19.51%, P = 0.0023. Conclusion Our findings highlight that the number of cases of ovarian cancer is constantly increasing in the last ten years and that endometriosis represents a serious risk factor which

  5. Patterns and predictors of sitting time over ten years in a large population-based Canadian sample: Findings from the Canadian Multicentre Osteoporosis Study (CaMos)

    OpenAIRE

    Gebel, Klaus; Pont, Sarah; Ding, Ding, W.; Bauman, Adrian E.; Chau, Josephine Y; Berger, Claudie; Prior, Jerilynn C; ,

    2017-01-01

    Our objective was to describe patterns and predictors of sedentary behavior (sitting time) over 10 years among a large Canadian cohort. Data are from the Canadian Multicentre Osteoporosis Study, a prospective study of women and men randomly selected from the general population. Respondents reported socio-demographics, lifestyle behaviors and health outcomes in interviewer-administered questionnaires; weight and height were measured. Baseline data were collected between 1995 and 1997 (n = 9418...

  6. Ten years of MIPAS measurements with ESA Level 2 processor V6 – Part 1: Retrieval algorithm and diagnostics of the products

    Directory of Open Access Journals (Sweden)

    P. Raspollini

    2013-09-01

    Full Text Available The MIPAS (Michelson Interferometer for Passive Atmospheric Sounding instrument on the Envisat (Environmental satellite satellite has provided vertical profiles of the atmospheric composition on a global scale for almost ten years. The MIPAS mission is divided in two phases: the full resolution phase, from 2002 to 2004, and the optimized resolution phase, from 2005 to 2012, which is characterized by a finer vertical and horizontal sampling attained through a reduction of the spectral resolution. While the description and characterization of the products of the ESA processor for the full resolution phase has been already described in previous papers, in this paper we focus on the performances of the latest version of the ESA (European Space Agency processor, named ML2PP V6 (MIPAS Level 2 Prototype Processor, which has been used for reprocessing the entire mission. The ESA processor had to perform the operational near real time analysis of the observations and its products needed to be available for data assimilation. Therefore, it has been designed for fast, continuous and automated analysis of observations made in quite different atmospheric conditions and for a minimum use of external constraints in order to avoid biases in the products. The dense vertical sampling of the measurements adopted in the second phase of the MIPAS mission resulted in sampling intervals finer than the instantaneous field of view of the instrument. Together with the choice of a retrieval grid aligned with the vertical sampling of the measurements, this made ill-conditioned the retrieval problem of the MIPAS operational processor. This problem has been handled with minimal changes to the original retrieval approach but with significant improvements nonetheless. The Levenberg–Marquardt method, already present in the retrieval scheme for its capability to provide fast convergence for nonlinear problems, is now also exploited for the reduction of the ill-conditioning of

  7. Itens alimentares no consumo alimentar de crianças de 7 a 10 anos Food items in the food intake of children aged seven to ten years

    Directory of Open Access Journals (Sweden)

    Patrícia de Fragas Hinnigi

    2012-06-01

    and macronutrients was calculated. The list was based on information provided by a 3-day-Food Diary completed by 85 schoolchildren ranging from seven to ten years old and enrolled in a public school in São Paulo, Brazil. After dividing the food into 129 items, we calculated the percentage in which each item contributed to diet nutrient intake and identified those which contributed to up to 95% of the total intake of calories and selected nutrients. RESULTS: The items "White rice, Greek rice, rice with vegetables" and "Brown, black and white beans, lentils" contributed significantly to the total intake of energy and carbohydrates. The item "Whole milk, powdered milk" had a significant participation in the total intake of lipids, protein and energy. We emphasize the importance of carbohydrates and energy intake from sugar-sweetened beverages (sodas and processed juices in the total diet intake of the children. CONCLUSIONS: the contribution of rice in the total food intake of energy and carbohydrates; of beans in energy, carbohydrates and proteins; of milk and meat in energy, protein and lipids; and bread in energy and carbohydrates is noticeable. The participation of sugar-sweetened beverage in the total intake in energy and carbohydrates and of candies in the total intake of lipids is also evident.

  8. Ten-year results of accelerated hypofractionated adjuvant whole-breast radiation with concomitant boost to the lumpectomy cavity after conserving surgery for early breast cancer.

    Science.gov (United States)

    Cante, Domenico; Petrucci, Edoardo; Sciacero, Piera; Piva, Cristina; Ferrario, Silvia; Bagnera, Silvia; Patania, Sebastiano; Mondini, Guido; Pasquino, Massimo; Casanova Borca, Valeria; Vellani, Giorgio; La Porta, Maria Rosa; Franco, Pierfrancesco

    2017-09-01

    Accelerated hypofractionated whole-breast radiotherapy (WBRT) is considered a standard therapeutic option for early breast cancer (EBC) in the postoperative setting after breast conservation (BCS). A boost to the lumpectomy cavity may further increase local control. We herein report on the 10-year results of a series of EBC patients treated after BCS with hypofractionated WBRT with a concomitant photon boost to the surgical bed over 4 weeks. Between 2005 and 2007, 178 EBC patients were treated with a basic course of radiotherapy consisting of 45 Gy to the whole breast in 20 fractions (2.25 Gy daily) with an additional boost dose of 0.25 Gy delivered concomitantly to the lumpectomy cavity, for an additional dose of 5 Gy. Median follow-up period was 117 months. At 10-year, overall, cancer-specific, disease-free survival and local control were 92.2% (95% CI 88.7-93.4%), 99.2% (95% CI 96.7-99.7%), 95.5% (95% CI 91.2-97.2%) and 97.3% (95% CI 94.5-98.9%), respectively. Only eight patients recurred. Four in-breast recurrences, two axillary node relapses and two metastatic localizations were observed. Fourteen patients died during the observation period due to other causes while breast cancer-related deaths were eight. At last follow-up, ≥G2 fibrosis and telangiectasia were seen in 7% and 5% of patients. No major lung and heart toxicities were observed. Cosmetic results were excellent/good in 87.8% of patients and fair/poor in 12.2%. Hypofractionated WBRT with concomitant boost to the lumpectomy cavity after BCS in EBC led to consistent clinical results at 10 years. Hence, it can be considered a valid treatment option in this setting.

  9. Transforming Growth Factor β-1 (TGF-β1) Is a Serum Biomarker of Radiation Induced Fibrosis in Patients Treated With Intracavitary Accelerated Partial Breast Irradiation: Preliminary Results of a Prospective Study

    Energy Technology Data Exchange (ETDEWEB)

    Boothe, Dustin L. [Weill Cornell Medical College of Cornell University, New York, New York (United States); Coplowitz, Shana [Department of Radiation Oncology, Stich Radiation Center, Weill Cornell Medical College of Cornell University, New York, New York (United States); Greenwood, Eleni [Weill Cornell Medical College of Cornell University, New York, New York (United States); Barney, Christian L. [Department of Radiation Oncology, Ohio State University, Columbus, Ohio (United States); Christos, Paul J. [Division of Biostatistics and Epidemiology, Department of Public Health, Weill Cornell Medical College of Cornell University, New York, New York (United States); Parashar, Bhupesh; Nori, Dattatreyudu; Chao, K. S. Clifford [Department of Radiation Oncology, Stich Radiation Center, Weill Cornell Medical College of Cornell University, New York, New York (United States); Wernicke, A. Gabriella, E-mail: gaw9008@med.cornell.edu [Department of Radiation Oncology, Stich Radiation Center, Weill Cornell Medical College of Cornell University, New York, New York (United States)

    2013-12-01

    Purpose: To examine a relationship between serum transforming growth factor β -1 (TGF-β1) values and radiation-induced fibrosis (RIF). Methods and Materials: We conducted a prospective analysis of the development of RIF in 39 women with American Joint Committee on Cancer stage 0-I breast cancer treated with lumpectomy and accelerated partial breast irradiation via intracavitary brachytherapy (IBAPBI). An enzyme-linked immunoassay (Quantikine, R and D, Minneapolis, MN) was used to measure serum TGF-β1 before surgery, before IBAPBI, and during IBAPBI. Blood samples for TGF-β1 were also collected from 15 healthy, nontreated women (controls). The previously validated tissue compliance meter (TCM) was used to objectively assess RIF. Results: The median time to follow-up for 39 patients was 44 months (range, 5-59 months). RIF was graded by the TCM scale as 0, 1, 2, and 3 in 5 of 20 patients (25%), 6 of 20 patients (30%), 5 of 20 patients (25%), and 4 of 20 patients (20%), respectively. The mean serum TGF-β1 values were significantly higher in patients before surgery than in disease-free controls, as follows: all cancer patients (30,201 ± 5889 pg/mL, P=.02); patients with any type of RIF (32,273 ± 5016 pg/mL, P<.0001); and women with moderate to severe RIF (34,462 ± 4713 pg/mL, P<0.0001). Patients with moderate to severe RIF had significantly elevated TGF-β1 levels when compared with those with none to mild RIF before surgery (P=.0014) during IBAPBI (P≤0001), and the elevation persisted at 6 months (P≤.001), 12 months (P≤.001), 18 months (P≤.001), and 24 months (P=.12). A receiver operating characteristic (ROC) curve of TGF-β1 values predicting moderate to severe RIF was generated with an area under the curve (AUC){sub ROC} of 0.867 (95% confidence interval 0.700-1.000). The TGF-β1 threshold cutoff was determined to be 31,000 pg/mL, with associated sensitivity and specificity of 77.8% and 90.0%, respectively. Conclusions: TGF-β1 levels correlate with

  10. Autophagy in Hepatic Fibrosis

    Directory of Open Access Journals (Sweden)

    Yang Song

    2014-01-01

    Full Text Available Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Hepatic fibrosis is usually associated with chronic liver diseases caused by infection, drugs, metabolic disorders, or autoimmune imbalances. Effective clinical therapies are still lacking. Autophagy is a cellular process that degrades damaged organelles or protein aggregation, which participates in many pathological processes including liver diseases. Autophagy participates in hepatic fibrosis by activating hepatic stellate cells and may participate as well through influencing other fibrogenic cells. Besides that, autophagy can induce some liver diseases to develop while it may play a protective role in hepatocellular abnormal aggregates related liver diseases and reduces fibrosis. With a better understanding of the potential effects of autophagy on hepatic fibrosis, targeting autophagy might be a novel therapeutic strategy for hepatic fibrosis in the near future.

  11. How Is Cystic Fibrosis Treated?

    Science.gov (United States)

    ... page from the NHLBI on Twitter. How Is Cystic Fibrosis Treated? Cystic fibrosis (CF) has no cure. However, ... help oral pancreatic enzymes work better. Treatments for Cystic Fibrosis Complications A common complication of CF is diabetes . ...

  12. Genetics Home Reference: cystic fibrosis

    Science.gov (United States)

    ... Me Understand Genetics Home Health Conditions cystic fibrosis cystic fibrosis Enable Javascript to view the expand/collapse boxes. Download PDF Open All Close All Description Cystic fibrosis is an inherited disease characterized by the buildup ...

  13. Neonatal cystic fibrosis screening test

    Science.gov (United States)

    Cystic fibrosis screening - neonatal; Immunoreactive trypsinogen; IRT test; CF - screening ... Cystic fibrosis is a disease passed down through families. CF causes thick, sticky mucus to build up in ...

  14. Continuous distal migration and internal rotation of the C-stem prosthesis without any adverse clinical effects: an RSA study of 33 primary total hip arthroplasties followed for up to ten years.

    Science.gov (United States)

    von Schewelov, T; Carlsson, A; Sanzén, L; Besjakov, J

    2014-05-01

    In 2005, we demonstrated that the polished triple-tapered C-stem at two years had migrated distally and rotated internally. From that series, 33 patients have now been followed radiologically, clinically and by radiostereometric analysis (RSA) for up to ten years. The distal migration within the cement mantle had continued and reached a mean of 2 mm (0.5 to 4.0) at ten years. Internal rotation, also within the cement mantle, was a mean 3.8° (external 1.6° to internal 6.6°) The cement mantle did not show any sign of migration or loosening in relation to the femoral bone. There were no clinical or radiological signs indicating that the migration or rotation within the cement mantle had had any adverse effects for the patients.

  15. Fibrosis and Cancer

    DEFF Research Database (Denmark)

    Cox, Thomas R.; Erler, Janine T.

    2016-01-01

    The relation between fibrosis and cancer has long been debated, specifically whether desmoplasia precedes, accompanies, or succeeds tumourigenesis, progression, and metastasis. Recent reports have published opposing data, adding to the perplexity. However, what is emerging is that it is likely...... the specific properties of the extracellular matrix (ECM) that determine the paradoxical nature of cancer-associated fibrosis....

  16. Fibrosis and Cardiac Arrhythmias

    NARCIS (Netherlands)

    de Jong, Sanne; van Veen, Toon A. B.; van Rijen, Harold V. M.; de Bakker, Jacques M. T.

    2011-01-01

    In this review article about fibrosis and arrhythmias, we show that the amount of collagen, a normal element of the heart muscle, increases with age and in heart disease. The relation between fibrosis and electrophysiological parameters such as conduction, fractionation of electrograms, abnormal imp

  17. Ten-year Pain, Ten-year Gain On the 10th Anniversary of Journal of Zhejiang Industry & Trade Vocational College%十年汗水 十年收获——浙江工贸职业技术学院学报创刊十周年纪念

    Institute of Scientific and Technical Information of China (English)

    詹振权

    2012-01-01

    浙江工贸职业技术学院学报作为正式学术刊物,已整整10年。追忆创刊、办刊的历程,学报的成长与学校的发展息息相关,可以说是学校文化的缩影。学报特定的功能中,它作为学校重要的“另张名片”,对教育思想的宣传、教育教学改革经验的推广、教师队伍建设和教育理论及方法研究的交流等方面,发挥了重要的作用。借学报创刊10周年之际,在总结办刊经验的同时,共谋学院新一轮的发展,再创辉煌,这应是纪念的意义所在。%It has been ten years since Journal of Zhejiang Industry and Trade Vocational College became a tormal acaaemic journal Looking back to the process of its beginning publication and management, the growth of the journal is closely related to the development of college, thus it can be said as a miniature of college culture. As "another name card" of college, the special function of college journal plays an important role in the dissemination of educational thoughts, the promotion of reform experience of education and teaching, the construction of teaching staff, and the communication of educational theory and research methodology. On the lOth anniversary of journal, the significance of memories should be emphasized on the co-creation of brilliant achievements for a newly development of college when we make a conclusion of the experience of journal management.

  18. Prevalence of SCN1A-related dravet syndrome among children reported with seizures following vaccination: a population-based ten-year cohort study.

    Directory of Open Access Journals (Sweden)

    Nienke E Verbeek

    Full Text Available OBJECTIVES: To determine the prevalence of Dravet syndrome, an epileptic encephalopathy caused by SCN1A-mutations, often with seizure onset after vaccination, among infants reported with seizures following vaccination. To determine differences in characteristics of reported seizures after vaccination in children with and without SCN1A-related Dravet syndrome. METHODS: Data were reviewed of 1,269 children with seizures following immunization in the first two years of life, reported to the safety surveillance system of the Dutch national immunization program between 1 January 1997 and 31 December 2006. Selective, prospective follow-up was performed of children with clinical characteristics compatible with a diagnosis of Dravet syndrome. RESULTS: In 21.9% (n = 279 of children, a diagnosis of Dravet syndrome could not be excluded based on available clinical data (median age at follow-up 16 months. Additional follow-up data were obtained in 83.9% (n = 234 of these children (median age 8.5 years. 15 (1.2% of 1,269; 95%CI:0.6 to 1.8% children were diagnosed with SCN1A-related Dravet syndrome. Of all reported seizures following vaccinations in the first year of life, 2.5% (95%CI:1.3 to 3.6% were due to SCN1A-related Dravet syndrome, as were 5.9% of reported seizures (95%CI:3.1 to 8.7% after 2(nd or 3(rd DTP-IPV-Hib vaccination. Seizures in children with SCN1A-related Dravet syndrome occurred more often with a body temperature below 38.5°C (57.9% vs. 32.6%, p = 0.020 and reoccurred more often after following vaccinations (26.7% vs. 4.0%, p = 0.003, than in children without a diagnosis of SCN1A-related Dravet Syndrome. CONCLUSIONS: Although Dravet syndrome is a rare genetic epilepsy syndrome, 2.5% of reported seizures following vaccinations in the first year of life in our cohort occurred in children with this disorder. Knowledge on the specific characteristics of vaccination-related seizures in this syndrome might promote early diagnosis

  19. Learn About Pulmonary Fibrosis

    Science.gov (United States)

    ... Fibrosis Month - Hope of a Better Future Blog: Yoga, Tai Chi and Your Lungs: The Benefits of ... number of items"); $("#local_list_xml").quickPagination(); }, error: function() { console.log("An error occurred while processing XML ...

  20. Angiogenesis and liver fibrosis

    Institute of Scientific and Technical Information of China (English)

    Gülsüm ?zlem Elpek

    2015-01-01

    Recent data indicate that hepatic angiogenesis,regardless of the etiology, takes place in chronic liverdiseases (CLDs) that are characterized by inflammationand progressive fibrosis. Because antiangiogenictherapy has been found to be efficient inthe prevention of fibrosis in experimental models ofCLDs, it is suggested that blocking angiogenesis couldbe a promising therapeutic option in patients withadvanced fibrosis. Consequently, efforts are beingdirected to revealing the mechanisms involved inangiogenesis during the progression of liver fibrosis.Literature evidences indicate that hepatic angiogenesisand fibrosis are closely related in both clinical andexperimental conditions. Hypoxia is a major inducer ofangiogenesis together with inflammation and hepaticstellate cells. These profibrogenic cells stand at theintersection between inflammation, angiogenesis andfibrosis and play also a pivotal role in angiogenesis.This review mainly focuses to give a clear view on therelevant features that communicate angiogenesis withprogression of fibrosis in CLDs towards the-end point ofcirrhosis that may be translated into future therapies.The pathogenesis of hepatic angiogenesis associatedwith portal hypertension, viral hepatitis, non-alcoholicfatty liver disease and alcoholic liver disease are alsodiscussed to emphasize the various mechanisms involvedin angiogenesis during liver fibrogenesis.

  1. 浑善达克沙地10年生态恢复回顾与展望%Ten-year-period Demonstration Project in Hunshandake Sandland and Prospect for the Future Development of Eco-stock FarmingIndustry

    Institute of Scientific and Technical Information of China (English)

    蒋高明; 刘美珍; 牛书丽; 李永庚; 彭羽; 李刚; 苏本营

    2011-01-01

    2000年以来,为配合国家“京津风沙源治理工程”,中国科学院在浑善达克沙地启动了“浑善达克和京北农牧交错区退化生态系统恢复试验示范研究”重大课题,连续开展了10年的生态恢复工作,取得了重大进展.项目实验区内蒙古正蓝旗巴音胡舒嘎查有72户288口牧民、面积8400hm2的沙地草地,具有流动沙丘、半固定沙丘、固定沙丘、滩地、湿地5种景观类型.经过10年生态治理,沙地草地得到了基本恢复,困扰国家的沙尘暴问题基本得到解决;牧民结束了买草历史,每年牧草出现富余;通了公路;牧民住上了新房,安装了交流电;有了自来水,改善了卫生条件;建立了中国草原上最大的“以禽代畜”示范基地.巴音胡舒试验区,作为荒漠化防治与生物多样性保护的典型案例,被媒体大量报道,并进入美国大学教科书.10年来,浑善达克生态恢复取得了明显的生态、社会与经济效益.本文简要回顾了试验的具体做法、取得的进展及存在的问题,并对今后大规模推广应用该试验成果提出了可具操作性的建议.%In order to realize the national goal of "combating dust storm and desertification in northern Beijing-Tianjin region", since 2000, the Chinese Academy of Sciences has initiated a huge demonstration project in Hunshandake Sandland and Northern Beijing agriculture-pasture trans-zones. After 10 years' experiment in Hunshandake Sandland, great achievements are realized both ecologically and economically. Bayinhushu, the village where the demonstration project was conducted, has 72 household, 288 persons, and a sandland area of 8400hm2. The main landscapes include shifting sand dunes, semi-shifting sand dunes, fixed sand dunes, meadows, and wetlands. The serious land degradation has been controlled, plentiful sandland vegetation is recovered, and dust storms are ceased in the demonstration area. The local herdsmen have ended the history of buying forages during winter and early spring from the market, nowadays, they are able to sell the superfluous forages to the market Herdsmen of Bayinhushu now have their own driveways, new houses, tap-waters, and bathrooms; the living standard is significantly improved. The largest demonstration base for "replacing livestock with poultry" in China's grassland has established. The successful restoration story of Bayinhushu, especially as the case of desertification prevention and biodiversity conservation, has been intensively reported by academic journals and/or media both nationwide and intemationwide. The prestigious Science magazine once reported the project achievement as a great ecological event in its special column of News Focus. The US college textbook, Geology and the Environment (6e), also refers Hunshandake story as the successful case of dust storm controlling. The main approaches, achievements, and challenges involving the demonstration project after 10 years' operation are concisely reviewed. Suggestions that are based on the actual practices and go far toward the sustainable development of eco-stock fanning industry in a large region of grassland, especially in the four main sandlands in China have been put forward.

  2. 近十年中国城镇青年失业问题研究回顾与展望%The Reflections and Prospects of China Urban Youth Unemployment Study in Recent Ten Years

    Institute of Scientific and Technical Information of China (English)

    张子凤

    2011-01-01

    我国学者及社会各界对城镇青年失业问题十分关注,进行了大量探索并且取得十分丰硕的成果。本文在梳理我国城镇青年失业问题研究的基础上,重点对城镇青年失业问题现状与特征、产生原因、影响、治理策略进行归纳和总结。最后对城镇青年失业问题研究进行了述评及展望,明确进一步研究的方向和思路。%Chinese scholars and the society from all walks of life pay much attention to urban youth unemployment,for exploring and obtain very fruitful.Based on comprehensive comb China town of youth unemployment problems,the research focus on urban youth unemploym

  3. Review and Prospect on the Research of Internet Culture Security at Home and Abroad in Recent Ten Years%近十年国内外网络文化安全研究的评述与展望∗

    Institute of Scientific and Technical Information of China (English)

    宋红岩; 汪向红

    2016-01-01

    随着网络产业革命、文化创新与社会变革的不断协同演进,网络文化安全问题越来越受到社会、政府、学界乃至社会公众的关注,但是国内外对网络文化安全内涵并没有定论。当前国内外学者对网络文化安全的定义、内容与要素进行了多元的诠释,学界对网络文化安全建设的政策机制、媒介融合、内容分级分类与社会公众素质等发展现状进行了探讨,各国也从国家顶层设计、技术创新与素养提升等层面进行了建设。应在梳理国内外网络文化安全发展建设的基础上,从我国网络文化安全战略要求提出理论构建、战略安排与协同创新路径安排。%With the co-evolution of the internet industrial revolution, cultural innovation and social change, internet culture secur⁃ity is attracting attention from the society, government, academic circles and the public, but there is not an unified definition at home and abroad on the connotation of internet culture security. Current domestic and foreign scholars have illustrated plurally the definition, content and elements of internet culture security, with discussing the construction of internet culture safety′s policy mechanism, media convergence, content classification and the public as well as the literacy of the public. Countries all over the world also are constructing their internet culture security from the national top layer design, technological innovation and quality improvement. On the basis of com⁃bing the domestic and abroad internet culture security construction and development, from the security strategy of China′s Internet cul⁃ture requirements, the paper will put forward the theoretical framework of ideas, strategic arrangement and collaborative innovation path arrangement for the internet culture security in China.

  4. Ten years of integrated care in Switzerland

    Directory of Open Access Journals (Sweden)

    Peter Berchtold

    2011-03-01

    Full Text Available In Switzerland, a growing part of primary care is provided by networks of physicians and health maintenance organizations (HMOs acting on the principles of gatekeeping. To date, an average of one out of eight insured person in Switzerland, and one out of three in the regions in north-eastern Switzerland, opted for the provision of care by general practitioners in one of the 86 physician networks or HMOs. About 50% of all general practitioners and more than 400 other specialists have joined a physician networks. Seventy-three of the 86 networks (84% have contracts with the healthcare insurance companies in which they agree to assume budgetary co-responsibility, i.e. to adhere to set cost targets for particular groups of patients. Within and outside the physician networks, at regional and/or cantonal levels, several initiatives targeting chronic diseases have been developed, such as clinical pathways for heart failure and breast cancer patients or chronic disease management programs for patients with diabetes. The relevance of these developments towards more integration of healthcare as well as their implications for the future are discussed.

  5. Virgin galactic the first ten years

    CERN Document Server

    Seedhouse, Erik

    2015-01-01

    Thirty years ago when Sir Richard Branson called up Boeing and asked if they had a spare 747, few would have predicted the brash entrepreneur would so radically transform the placid business of air travel. But today, Branson flies airlines on six continents, employs hundreds of jets and, in 2014, was predicting that his spaceship company – Virgin Galactic – would soon open the space frontier to commercial astronauts, payload specialists, scientists and space tourists. With more than 600 seats sold at $250,000 each, what started off as a dream to send people just for the excitement to look back and marvel at Earth, was on the cusp of finally being turned into a business. Then, on October 21, 2014, tragedy struck. SpaceShipTwo was on its most ambitious test flight to date. Seconds after firing its engine, Virgin Galactic’s spaceship was breaking through the sound barrier. In just the three seconds that it took for the vehicle to climb from Mach 0.94 to Mach 1.02, co-pilot Mike Alsbury made what many close...

  6. Ten years of International Migratory Bird Day

    Science.gov (United States)

    Jennifer Wheeler; Susan Bonfield

    2005-01-01

    Public awareness and concern are crucial components of migratory bird conservation. Citizens who are enthusiastic about birds, informed about threats, and empowered to become involved in addressing those threats can make a tremendous contribution to maintaining healthy bird populations. One of the most successful vehicles for public education on migratory birds is...

  7. Ten years of fighting bird flu

    OpenAIRE

    Parry, Jane

    2007-01-01

    This year marks a decade since the first human outbreak of H5N1 avian influenza in Hong Kong. Since then, US $1.9 billion has been pledged to fight avian influenza and a global effort is under way to prevent and be prepared for a pandemic.

  8. "ON-AIR SECRETS": TEN YEARS LATER

    Directory of Open Access Journals (Sweden)

    Bysko Maxim V.

    2013-12-01

    Full Text Available The article is a scientific review on the training manual On-air secret by Andrey Bubukin, published in 2003. This guide has been written by a man who never had anything to do with radio, but by the will of fate suddenly became at once the program director of Russia's first non-state radio station Europa Plus Moscow, the commercial music radio. Then came to the fore not the questions of art qualities of broadcast, but technical-mathematical details of the automated programming of song material. Therefore, at the end of the Soviet broadcasting, it became possible appearance some people obviously alien to the electronic mass media. They are, however, strongly influenced the further "format" broadcasting in new Russia, so as the principles of songs rotation and playlist making on the radio still can’t do without recourse to the Bubukin's textbook. There are serious concerns about the fact that the book is intended not only for program directors, but for the music editors also. Extremely dubious assertions and recommendations related to the problems of arts, journalism, radio-presenter's skill, history of radio.

  9. Changes in Ten Years In Nyingchi

    Institute of Scientific and Technical Information of China (English)

    1996-01-01

    ChangesinTenYearsInNyingchiYUANSHABOnthemorningofApril30,agroupofleadersoftheTibetAutonomousRegionleftLhasaforNvinZchi.Theywe...

  10. China's Innovation System: Ten years on

    DEFF Research Database (Denmark)

    Lundvall, Bengt-Åke; Gu, Shulin; Schwaag Serber, Sylvia

    2016-01-01

    In their 2006 article on innovation in China in this journal, Gu and Lundvall pointed to some weaknesses and challenges for China’s growth and they also outlined ideas for policy action to overcome those. In this short note, written in collaboration with Sylvia Schwag Serger, they go back and ass...

  11. The pyroelectric vidicon - Ten years on

    Science.gov (United States)

    Burgess, D.; Nixon, R.; Ritchie, J.

    1986-01-01

    A technology development status evaluation is presented for British high performance pyroelectric vidicon, IR-sensitive TV cameras, the first tubes and cameras of which were demonstrated over a decade ago. Attention is given to the improvements that had to be instituted in camera design in order to obtain optimum performance from the vidicon tubes. A rotating disk chopper and flicker processing were incorporated into the camera's design. Pyroelectric cameras have been extensively applied in industry and the police and military services for fire detection and in rescue operations.

  12. Educating All Children: Ten Years Later.

    Science.gov (United States)

    Gerber, Michael M.; Levine-Donnerstein, Deborah

    1989-01-01

    In this review of the "Tenth Annual Report to Congress on the Implementation of the Education of the Handicapped Act" (Public Law 94-142), data are cited concerning: current status of services, dropout rates from secondary special education, implementation of preschool special education services, and state variations in the…

  13. China-EU Over Ten Years

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The 10th China-EU Meeting took place in Beijing on November 28, 2007. This was an important annual meeting held at a critical point in the history of China-EU relations. Since this regularly scheduled meeting was first established in 1998, leaders from both China and the EU have met continuously. Over the past decade, many fundamental changes have taken place between China and the EU, and the China-EU relationship has evolved into full strategic partnership.

  14. Hong Kong: Ten Years After the Handover

    Science.gov (United States)

    2007-06-29

    stockholder of the newspaper, Robert Kuok Hock Nien; and in 2004, the hosts of the radio shows “Smoke Signals” (Fung Yin), “Teacup in a Tempest” (Fung Bor...35 For a description of the pre-Handover Hong Kong economic network, see Hong Hong Advantage, by Michael Enright , Edith Scott, and David Dodwell...Hong Kong & the Pearl River Delta: The Economic Interaction, by Michael J. Enright , Chang Ka Mun, Edith Scott, and Zhu Wen Hui, sponsored by the 2022

  15. Ten years left to eliminate blinding trachoma

    Directory of Open Access Journals (Sweden)

    Haddad D.

    2010-09-01

    Full Text Available n 1997, the World Health Organization formed the Global Alliance to Eliminate Blinding Trachoma by 2020 (GET 2020, a coalition of governmental, non-governmental, research, and pharmaceutical partners. In 1998, the World Health Assembly urged member states to map blinding trachoma in endemic areas, implement the SAFE strategy (which stands for surgery for trichiasis, antibiotics, facial-cleanliness and environmental change, such as clean water and latrines and collaborate with the global alliance in its work to eliminate blinding trachoma.

  16. Ten Years of the Armenian Virtual Observatory

    Science.gov (United States)

    Mickaelian, A. M.; Astsatryan, H. V.; Knyazyan, A. V.; Magakian, T. Yu.; Mikayelyan, G. A.; Erastova, L. K.; Hovhannisyan, L. R.; Sargsyan, L. A.; Sinamyan, P. K.

    2016-06-01

    Armenian Virtual Observatory (ArVO, www.aras.am/Arvo/arvo.htm) was created 10 years ago, in 2005, when after the accomplishment of the Digitized First Byurakan Survey (DFBS, www.aras.am/Dfbs/dfbs.html) we had enough resources to run a VO project and contribute in the International Virtual Observatory Alliance (IVOA, www.ivoa.net). ArVO is a project of Byurakan Astrophysical Observatory (BAO) aimed at construction of a modern system for data archiving, extraction, acquisition, reduction, use and publication. ArVO technical and research projects include Global Spectroscopic Database, which is being built based on DFBS. Quick optical identification of radio, IR or X-ray sources will be possible by plotting their positions in the DFBS or other spectroscopic plate and matching all available data. Accomplishment of new projects by combining data is so important that the International Council of Scientific Unions (ICSU) recently created World Data System (WDS, www.icsu-wds.org/) for unifying data coming from all science areas, and BAO has also joined it due to DFBS and ArVO projects.

  17. Ten years of the project Chain Experiment

    Science.gov (United States)

    Susman, Katarina; Ziherl, Saša; Bajc, Jurij

    2017-05-01

    In this paper the project Chain Experiment is presented. It can be viewed as a competition or as a popularization activity for science, technology, and physics in particular. We present the basic idea of a toppling-domino-like chain of contraptions that are operated one after another, and each demonstrates different physical phenomena. The evolution into its current form with three different types of activities is briefly described. The emphasis of the paper is on the impact of the project on physics education. The ways in which physics students, physics teachers, and participating pupils profit from the different project activities are presented in detail.

  18. Ten years of SLR production in Argentina

    Science.gov (United States)

    Pacheco, A.; Podestá, R.; Yin, Z.; Liu, W.; Actis, E.; Adarvez, S.; Quinteros, J.; Podestá, F.

    2017-07-01

    SLR technique is a proved astro-geodetic art with a significant power to contribute to Earth and Space Sciences. Therefore, scientific applications of SLR System are able to perform multiple tasks in the fields of Astrometry, Geodesy and Geophysics. The results we show here were obtained from satellite observations made at SLR 7406 Station of Observatorio Astronómico Félix Aguilar (OAFA) in San Juan, Argentina. The telescope was installed early on 2006, in concordance with an International Cooperation Agreement between Universidad Nacional de San Juan, Argentina and Chinese Academy of Sciences. In this abstract we show the current research being done with ILRS 7406 station: Length of day (LOD) and Angular velocity of Earth Rotation, calculated weekly; Pole Motion. ILRS7406 is daily surveying Pole coordinates x and y; Tracking SLR to GNSS constellations. SLR System contributes to the adjustment and validation of satellite GALILEO, GPS, GLONASS, and BEIDOU orbits. Our station is nowadays member of the new ITRF 2014 frame, and these past years has been one of the 3 highest producing SLR Stations on the ILRS net, composed of about 40 stations distributed all around the world. The obtained results during this first 10 years of experience are useful to enhance the traditional collaboration between OAFA and international services such as ILRS, IERS and NASA.

  19. Ten Years of Art Imaging Research

    OpenAIRE

    Martinez, K.; Cupitt, J; Saunders, D; Pillay, R

    2002-01-01

    This paper describes a decade of work on digital imaging for museums. In 1989-92, the EU-funded VASARI project produced a digital imaging system that made colour-calibrated images of up to 20k x 20k pels directly from paintings. It used seven colour-separation bands in the visible region, resulting in an average colour error of around 1 deltaELab unit. These images have since been used to monitor the condition of paintings, to document paintings during conservation treatment, including predic...

  20. Late stillbirth: a ten year cohort study.

    Science.gov (United States)

    Robalo, Raquel; Pedroso, Célia; Amaral, Njila; Soares, Clara

    2013-01-01

    Introdução: A morte fetal tardia é um acontecimento que se mantém na prática diária, apesar de protocolos de vigilância pré-natal e intraparto. Objectivo: Análise dos factores que contribuíram para a causa principal ou condições associadas a morte fetal tardia num período de 10 anos Métodos: Coorte retrospectiva de 208 gestações tardias simples, cujo parto em unidade terciária de cuidados perinatais resultou no nascimento de um nado morto, num período de dez anos. Através de consulta de processo clínico foram analisados dados clínicos, laboratoriais e resultados de estudo anatomo-patológico feto-placentário. Resultados: A incidência de morte fetal tardia foi de 3,5 por cada 1000 nascimentos. Não foram encontradas quaisquer tendências na incidência de MF tardia ao longo do tempo de estudo. Em 12 (5,8%) casos a morte fetal foi um acontecimento intraparto e 72 (35%) eram gestações de termo. Em 14% a gravidez não foi vigiada. A IG média de diagnóstico foi 34 semanas. A principal causa de morte associou-se a patologia fetal, tendo sido identificados factores fetais em 59 casos, destes 25% foram considerados leves para a idade gestacional. Em 24.5% dos casos a causa de morte foi inexplicada. Identificaram-se factores de risco materno em 21% dos casos, a patologia hipertensiva foi frequente e foi associada a idade gestacional precoce (p = 0,028). Conclusões: Não houve oscilações na incidência de morte fetal tardia ao longo dos dez anos avaliados. A incidência foi de 3,5‰, idêntica à descrita em países desenvolvidos. Cerca de um quarto das mortes fetais foram inexplicadas. A patologia materna mais frequente foi a hipertensão crónica.

  1. Ten years of snakebites in Iran.

    Science.gov (United States)

    Dehghani, Rouhullah; Fathi, Behrooz; Shahi, Morteza Panjeh; Jazayeri, Mehrdad

    2014-11-01

    Many species of venomous snakes are found in Iran. The most medically important species which are responsible for the most snakebite incidents in Iran belong to the Viperidae family, including Vipera lebetina, Echis carinatus, Pseudocerastes persicus, Vipera albicornuta and the Elapidae family, especially Naja naja oxiana. At least one kind of venomous snake is found in each of the 31 provinces, and many provinces have more than one venomous species. As a result, snakebite is a considerable health hazard in Iran, especially in the rural area of south and south-west of Iran. A retrospective, descriptive study of snakebite in Iran during 2002-2011 was carried out in order based on data collected from medical records of bite victims admitted to hospitals and health centers. From 2002 to 2011, 53,787 cases of snake bites were reported by medical centers in Iran. The annual incidence of snake bites in 100,000 of population varied from 4.5 to 9.1 during this decade and the number of recorded deaths were about 67 cases. The highest rate of snakebite was found in provinces of south and southwest of Iran. We suggest that people, especially in the rural areas, need to be trained and educated about venomous snakes, their hazards, prevention of bite and the importance of early hospital referral and treatment of victims. Also adequate antivenins as the main life saving medicine should be made available based on the recorded numbers of victims in each area of the country.

  2. Ten years of CR physics with PAMELA

    Science.gov (United States)

    Galper, A.; Spillantini, P.

    2017-09-01

    The satellite borne Pamela instrument is dedicated to the precise and high statistics study of CR fluxes on a four decades energy range. Pamela experiment is the last step of the "Russian-Italian Mission" (RIM) program established in 1992 between several Italian and Russian institutes and with the participation of Sweden and Germany. Designed as a cosmic ray observatory at 1 AU, it extensive program is made possible thanks to the outstanding performance of the instrument, the low energy threshold, the quasi-polar orbit and the 10 years duration of the observation. The physics program pays particular attention to the study of particles and antiparticles fluxes and includes search for dark matter, primordial antimatter, new matter in the Universe, study of cosmic-ray propagation, solar physics and solar modulation, and terrestrial magnetosphere. Very important is the discovery of the anomalous increase of the positron flux at energies higher that 50 GeV (the so called "Pamela anomaly"), and the abrupt spectral hardening of H and He, challenging the current paradigm of cosmic-ray acceleration and propagation in the Galaxy.

  3. Stellar populations -- the next ten years

    CERN Document Server

    Bland-Hawthorn, J

    2007-01-01

    The study of stellar populations is a discipline that is highly dependent on both imaging and spectroscopy. I discuss techniques in different regimes of resolving power: broadband imaging (R~4), intermediate band imaging (R~16, 64), narrowband spectral imaging (R~256, 1024, 4096). In recent years, we have seen major advances in broadband all-sky surveys that are set to continue across optical and IR bands, with the added benefit of the time domain, higher sensitivity, and improved photometric accuracy. Tunable filters and integral field spectrographs are poised to make inroads into intermediate and narrowband imaging studies of stellar populations. Further advances will come from AO-assisted imaging and imaging spectroscopy, although photometric accuracy will be challenging. Integral field spectroscopy will continue to have a major impact on future stellar population studies, extending into the near infrared once the OH suppression problem is finally resolved. A sky rendered dark will allow a host of new idea...

  4. Endomyocardial fibrosis in infancy

    Directory of Open Access Journals (Sweden)

    Jatene Marcelo Biscegli

    2003-01-01

    Full Text Available The patient was a 4-month-old infant, who underwent persistent ductus arteriosus interruption with titanium clips at the age of 13 days and, since the age of 2 months, had crises of hypoxia and hypertonicity. After clinical investigation, the presence of pulmonary hypertension was confirmed and left ventricular inflow tract obstruction was suspected. The patient underwent surgical treatment at the age of 4 months, during which right and left ventricular endocardial fibrosis was identified. The fibrosis was resected, but the infant had an unfavorable clinical evolution with significant diastolic restriction and died on the sixth postoperative day. Anatomicopathological and surgical findings suggested endomyocardial fibrosis, although that pathology is very rare at the patient's age.

  5. 农十三师十年改水效果评价%An effect analysis on water improvement in the past ten years in the 13 division of Xinjiang production and construction corps

    Institute of Scientific and Technical Information of China (English)

    张改玲; 阿合买提; 李东; 李戈燕

    2011-01-01

    Objective:To study and appraisal the effect on water improvement in the past ten years in the 13 division of Xinjiang production and construction corps.Methods: According to the army corps drinking water implementation investigation plan,we choose the representative samples, based on "Drinking Water Testing Standard 2001 "and" the Criterion of the Countryside Implementing Drinking Water Health Standard", we test and evaluate the water.Results: Through the ten years water improvement ,the rate of centralism water supply is 98.4%, 100% qualified the second level of security drinking water sanitation standard.There is an inverse correlation between the growth rate of benefit population and the incidence rate of the water intestinal tract infectious disease( r= -0.6559 ,P <0.05 ).Conclusion: The hygiene condition of drinking water got a significant enhancement.The incidence rate of the intestinal tract infectious disease reduced obviously.The water improvement in the past ten years made the remarkable hygienic progress.%目的:对农十三师十年改水效果进行分析评价.方法:依据兵团生活饮用水实施调查方案,选择有代表性水样,按照国家标准GB/T5750.1~5750.13-2006和GB5749-2006标准按进行进行水质检验和卫生等级评价.结果:通过十年改水工程,改水受益率达到92%,100%饮用水达到国家二级安全用水卫生标准,改水受益人口增长率与介水肠道传染病发病率二者之间呈负相关.结论:通过十年改水,饮用水卫生状况得到很大提高,改水受益率逐步提高,改水前后饮水水源类型和水质等级有极大改善,同时介水肠道传染病发病率逐年呈现明显下降趋势,取得了显著的社会效益和经济效益,十年改水效果显著.

  6. Pergolide-induced pleuropulmonary fibrosis

    NARCIS (Netherlands)

    Bleumink, G S; van der Molen-Eijgenraam, M; Strijbos, J H; Sanwikarja, S; van Puijenbroek, E P; Stricker, B H Ch

    2002-01-01

    Pleuropulmonary fibrosis is a rare, but well-recognized adverse effect of ergot alkaloids. We report on four patients who developed pleural and/or pulmonary fibrosis during treatment with pergolide and give characteristics of 87 cases with one or more symptoms of serosal fibrosis. Retroperitoneal an

  7. Poor mid-term survival of the low-carbide metal-on-metal Zweymüller-plus total hip arthroplasty system: a concise follow-up, at a minimum of ten years, of a previous report*.

    Science.gov (United States)

    Repantis, Thomas; Vitsas, Vasilis; Korovessis, Panagiotis

    2013-03-20

    Between 1994 and 1999, 217 metal-on-metal total hip arthroplasties with a low-carbide bearing surface were performed with use of the cementless Zweymüller SL-Plus stem and the Bicon-Plus threaded cup in 194 consecutive patients. After a minimum follow-up of ten years, 181 living patients (203 hips) were available for evaluation. The revision rate after an average of twelve years was 18% (thirty-six hips in thirty-six patients were revised). The main reason for revision was aseptic loosening of one or both components. The probability of survival of the stem at fifteen years was 77% (95% confidence interval [CI], 65% to 86%). The probability of survival of the cup was 80% (95% CI, 62% to 90%). These high failure rates at mid-term follow-up led us to abandon the use of low-carbide metal-on-metal total hip arthroplasty components.

  8. Hemangioma racemoso de retina (síndrome de Wyburn-Mason: acompanhamento de um paciente por dez anos: relato de caso Retinal racemose hemangioma (Wyburn-Mason syndrome: a patient ten years follow-up: case report

    Directory of Open Access Journals (Sweden)

    RL Leitão Guerra

    2009-08-01

    Full Text Available Relatar o caso de um paciente que apresentou hemangioma racemoso de retina (síndrome de Wyburn-Mason e seu acompanhamento por 10 anos. Dez anos após o diagnóstico da doença o exame oftalmológico não sofreu alterações, assim como o campo visual e a retinografia. O prognóstico a longo prazo é controverso. Alguns autores relatam estabilidade das lesões oculares, como no caso descrito, enquanto outros referem perda progressiva da visão.To describe the case of a patient who presents retinal racemose hemangioma (Wyburn-Mason syndrome and his 10 years follow-up. Ten years after the disease diagnosis, the ophthalmologic exam had no changes, as well as the campimetry and the retinography. The long term prognosis is controversial. Some authors report ocular lesions stability and others report progressive visual loss.

  9. Does the use of laminar flow and space suits reduce early deep infection after total hip and knee replacement?: the ten-year results of the New Zealand Joint Registry.

    Science.gov (United States)

    Hooper, G J; Rothwell, A G; Frampton, C; Wyatt, M C

    2011-01-01

    We have investigated whether the use of laminar-flow theatres and space suits reduced the rate of revision for early deep infection after total hip (THR) and knee (TKR) replacement by reviewing the results of the New Zealand Joint Registry at ten years. Of the 51 485 primary THRs and 36 826 primary TKRs analysed, laminar-flow theatres were used in 35.5% and space suits in 23.5%. For THR there was a significant increase in early infection in those procedures performed with the use of a space suit compared with those without (p space suit (p space suit (p space suits were used in those theatres (p deep infection has not been reduced by using laminar flow and space suits. Our results question the rationale for their increasing use in routine joint replacement, where the added cost to the health system seems to be unjustified.

  10. Mycobacterium abscessus and Children with Cystic Fibrosis

    OpenAIRE

    Sermet-Gaudelus, Isabelle; Le Bourgeois, Muriel; Pierre-Audigier, Catherine; Offredo, Catherine; Guillemot, Didier; Halley, Sophie; Akoua-Koffi, Chantal; Vincent, Véronique; Sivadon-Tardy, Valérie; Ferroni, Agnès; Berche, Patrick; Scheinmann, Pierre; Lenoir, Gérard; Gaillard, Jean-Louis

    2003-01-01

    We prospectively studied 298 patients with cystic fibrosis (mean age 11.3 years; range 2 months to 32 years; sex ratio, 0.47) for nontuberculous mycobacteria in respiratory samples from January 1, 1996, to December 31, 1999. Mycobacterium abscessus was by far the most prevalent nontuberculous mycobacterium: 15 patients (6 male, 9 female; mean age 11.9 years; range 2.5–22 years) had at least one positive sample for this microorganism (versus 6 patients positive for M. avium complex), including...

  11. A Comparative Study on Sexual Psychology of Undergraduate Students in Recent Ten Years%中国大学生近十年性心理比较研究

    Institute of Scientific and Technical Information of China (English)

    邵昌玉; 胡珍

    2011-01-01

    采用自编的大学生性文化调查问卷,于2000年调查了全国26所大学的5070名大学生,于2010年调查了全国53所大学的7829名大学生,对两次调查得出的结果进行分析研究,以了解近10年我国大学生性心理的变化趋势,并为高校开展性心理教育提供理论依据。结果显示:大学生异性化倾向较十年前有所改善;有过性幻想和性梦的大学生都较十年前有所减少;与异性交往的心理较十年前更开放。%The study surveyed 5070 undergraduate students from 26 universities in 2000, and 7829 undergraduate students from 53 universities in 2010 with self-developed undergraduate students' sexual culture questionnaire and compared the results so as to learn the tendency of undergraduate students' sexual psychological change in recent ten years and provide theoretical basis for sexual psychological education in universities. The results showed that the tendency of liking to be the opposite sex turned to be better, the number of undergraduate students decreased who have sexual fantasies and sexual dreams compared with ten years ago and undergraduate students are more open to contact with opposite sex students.

  12. Understanding Nephrogenic Systemic Fibrosis

    Directory of Open Access Journals (Sweden)

    Tushar Chopra

    2012-01-01

    Full Text Available Nephrogenic systemic fibrosis (NSF is a rare and a debilitating disease noted uncommonly in patients with impaired renal function when exposed to low-stability gadolinium-based contrast agents (Gd-CAs. According to experimental studies, cytokines released by the stimulation of effector cells such as skin macrophages and peripheral blood monocytes activate circulating fibroblasts which play a major role in the development of NSF lesions. The presence of permissive factors, presumably, provides an environment conducive to facilitate the process of fibrosis. Multiple treatment modalities have been tried with variable success rates. More research is necessary to elucidate the underlying pathophysiological mechanisms which could potentially target the initial steps of fibrosis in these patients. This paper attempts to collate the inferences from the in vivo and in vitro experiments to the clinical observations to understand the pathogenesis of NSF. Schematic representations of receptor-mediated molecular pathways of activation of macrophages and fibroblasts by gadolinium and the final pathway to fibrosis are incorporated in the discussion.

  13. Nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Khurram, Misbah; Skov, Lone; Rossen, Kristian

    2007-01-01

    Nephrogenic systemic fibrosis (NSF) is a fibrotic disease seen in renal failure patients that may lead to severe physical disability. It has been demonstrated in recent studies that NSF can be caused by some gadolinium-containing MRI contrast agents. In this report we present one of a total of 26...

  14. Nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Marckmann, Peter; Skov, Lone; Rossen, Kristian

    2006-01-01

    Nephrogenic systemic fibrosis is a new, rare disease of unknown cause that affects patients with renal failure. Single cases led to the suspicion of a causative role of gadodiamide that is used for magnetic resonance imaging. This study therefore reviewed all of the authors' confirmed cases of ne...

  15. Mycobacterium abscessus and Children with Cystic Fibrosis

    Science.gov (United States)

    Sermet-Gaudelus, Isabelle; Le Bourgeois, Muriel; Pierre-Audigier, Catherine; Offredo, Catherine; Guillemot, Didier; Halley, Sophie; Akoua-Koffi, Chantal; Vincent, Véronique; Sivadon-Tardy, Valérie; Ferroni, Agnès; Berche, Patrick; Scheinmann, Pierre; Lenoir, Gérard

    2003-01-01

    We prospectively studied 298 patients with cystic fibrosis (mean age 11.3 years; range 2 months to 32 years; sex ratio, 0.47) for nontuberculous mycobacteria in respiratory samples from January 1, 1996, to December 31, 1999. Mycobacterium abscessus was by far the most prevalent nontuberculous mycobacterium: 15 patients (6 male, 9 female; mean age 11.9 years; range 2.5–22 years) had at least one positive sample for this microorganism (versus 6 patients positive for M. avium complex), including 10 with >3 positive samples (versus 3 patients for M. avium complex). The M. abscessus isolates from 14 patients were typed by pulsed-field gel electrophoresis: each of the 14 patients harbored a unique strain, ruling out a common environmental reservoir or person-to-person transmission. Water samples collected in the cystic fibrosis center were negative for M. abscessus. This major mycobacterial pathogen in children and teenagers with cystic fibrosis does not appear to be acquired nosocomially. PMID:14720400

  16. Male fertility in cystic fibrosis.

    LENUS (Irish Health Repository)

    Chotirmall, S H

    2011-04-05

    Infertility rates among males with cystic fibrosis (CF) approximate 97%. No information is currently available within Ireland determining an understanding of fertility issues and the best methods of information provision to this specialized group. This study aimed to determine understanding and preferred approaches to information provision on fertility issues to Irish CF males. A Descriptive Study utilizing prospective coded questionnaires was mailed to a male CF cohort (n=50). Sections included demographics, fertility knowledge & investigation. Response rate was 16\\/50 (32%). All were aware that CF affected their fertility. More than two-thirds (n=11) were able to provide explanations whilst only one-third (n=5) provided the correct explanation. Significant numbers stated thoughts of marriage and a future family. Half have discussed fertility with a healthcare professional (HCP). Mean age of discussion was 21.9 years. One third preferred an earlier discussion. The commonest first source for information was written material which was also the preferred source. Three-quarters requested further information preferring again, written material. Significant gaps in sex education of Irish CF males exist. Discussion should be initiated by HCPs and centre-directed written material devised to address deficiencies.

  17. PROFILEing idiopathic pulmonary fibrosis: rethinking biomarker discovery

    Directory of Open Access Journals (Sweden)

    Toby M. Maher

    2013-06-01

    Full Text Available Despite major advances in the understanding of the pathogenesis of idiopathic pulmonary fibrosis (IPF, diagnosis and management of the condition continue to pose significant challenges. Clinical management of IPF remains unsatisfactory due to limited availability of effective drug therapies, a lack of accurate indicators of disease progression, and an absence of simple short-term measures of therapeutic response. The identification of more accurate predictors of prognosis and survival in IPF would facilitate counseling of patients and their families, aid communication among clinicians, and would guide optimal timing of referral for transplantation. Improvements in molecular techniques have led to the identification of new disease pathways and a more targeted approach to the development of novel anti-fibrotic agents. However, despite an increased interest in biomarkers of IPF disease progression there are a lack of measures that can be used in early phase clinical trials. Careful longitudinal phenotyping of individuals with IPF together with the application of novel omics-based technology should provide important insights into disease pathogenesis and should address some of the major issues holding back drug development in IPF. The PROFILE (Prospective Observation of Fibrosis in the Lung Clinical Endpoints study is a currently enrolling, prospective cohort study designed to tackle these issues.

  18. Adipose tissue fibrosis

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    The increasing prevalence of obesity causes a majorinterest in white adipose tissue biology. Adipose tissuecells are surrounded by extracellular matrix proteinswhose composition and remodeling is of crucial importancefor cell function. The expansion of adipose tissue inobesity is linked to an inappropriate supply with oxygenand hypoxia development. Subsequent activation ofhypoxia inducible factor 1 (HIF-1) inhibits preadipocytedifferentiation and initiates adipose tissue fibrosis. Therebyadipose tissue growth is limited and excess triglyceridesare stored in ectopic tissues. Stressed adipocytes andhypoxia contribute to immune cell immigration andactivation which further aggravates adipose tissuefibrosis. There is substantial evidence that adipose tissuefibrosis is linked to metabolic dysfunction,both in rodentmodels and in the clinical setting. Peroxisome proliferatoractivated receptor gamma agonists and adiponectin bothreduce adipose tissue fibrosis, inflammation and insulinresistance. Current knowledge suggests that antifibroticdrugs, increasing adipose tissue oxygen supply or HIF-1antagonists will improve adipose tissue function andthereby ameliorate metabolic diseases.

  19. Gadolinium-Induced Fibrosis.

    Science.gov (United States)

    Todd, Derrick J; Kay, Jonathan

    2016-01-01

    Gadolinium-based contrast agents (GBCAs), once believed to be safe for patients with renal disease, have been strongly associated with nephrogenic systemic fibrosis (NSF), a severe systemic fibrosing disorder that predominantly afflicts individuals with advanced renal dysfunction. We provide a historical perspective on the appearance and disappearance of NSF, including its initial recognition as a discrete clinical entity, its association with GBCA exposure, and the data supporting a causative relationship between GBCA exposure and NSF. On the basis of this body of evidence, we propose that the name gadolinium-induced fibrosis (GIF) more accurately reflects the totality of knowledge regarding this disease. Use of high-risk GBCAs, such as formulated gadodiamide, should be avoided in patients with renal disease. Restriction of GBCA use in this population has almost completely eradicated new cases of this debilitating condition. Emerging antifibrotic therapies may be useful for patients who suffer from GIF.

  20. Cystic fibrosis. Diagnosis.

    Directory of Open Access Journals (Sweden)

    Luis Ortigosa

    2009-11-01

    Full Text Available Cystic fibrosis (CF is one of the most frequent inherited mortal diseases in Caucasian population. Dysfunction in exocrine glands is described in CF patients, with severe pancreatic insufficiency and chronic lung disease. CF is inherited as an autosomal recessive disorder. More than 1000 disease-associated mutations in the cystic fibrosis transmembrane conductance regulator (CFTR gene have been described. DF508 mutation is the most common mutation in the CF gen. Diagnosis in CF is based on clinical and laboratory tests findings. Meconial ileus, CF in other relatives, chronic lung disease, congenital absence of the vas deferens with azoospermia are among other clinical findings, main criteria in CF patients. Two positive results in sweat chloride test , or demonstration in nasal epithelial ionic transport alteration (nasal potential difference and identification of two CF mutations in the patient are laboratory findings in CF.

  1. [News in cystic fibrosis].

    Science.gov (United States)

    Delaisi, B

    2013-08-01

    The improvement over the last two decades in the treatment of cystic fibrosis led to an increase in life expectancy approaching 40 years at birth. Logically, the population of adult patients has been increasing and is currently 50% of patients followed in France. These therapeutic advances have justified the establishment in 2003 of a generalized neonatal screening for cystic fibrosis. The latest data of this screening show an incidence of CF of 1/5359 live births, far below the incidence of 1/2500 which was widely accepted twenty years ago. The performance of this screening is currently based on the dosage of trypsin immuno reactive, followed in case of exceeding the threshold of a search of the 30 most common mutations, can detect around 96% of 150 to 200 CF cases every year. Therefore, the possibility of a false negative of the screening cannot be excluded and evocative symptoms of cystic fibrosis, even for children born after 2003, will lead to prescribe a sweat test. While treatments available so far goal consequences of cystic fibrosis, a new therapeutic class to correct the functional defect of the mutated protein, called CFTR modulators, is emerging. Ivacaftor, leader of this new class, belonging to the category of "CFTR potentiator" got its access on the market in September 2012 for patients carrying the G551D mutation. New other molecules, named "CFTR correctors" which can have synergistic effect with ivacaftor and concern patients carrying the most common mutation--DF 508--are under development. Copyright © 2013. Published by Elsevier Masson SAS.

  2. The Prospective Retrospective Memory Questionnaire: psychometric properties and normative data of a Dutch translation

    NARCIS (Netherlands)

    van der Werf, S.P.; Vos, S.

    2011-01-01

    Ten years ago the Prospective Retrospective Memory Questionnaire (PRMQ) was specifically developed to assess perceived problems concerning both episodic memory and memory for future intentions. Since then, various PRMQ translations have been carried out. These previous studies of this self­report me

  3. Clinical and Radiographic Evaluation of a Commercially Pure Cancellous-Structured Titanium Press Fit Total Hip Prosthetic Stem: Ten-Year Followup of the “Natural Hip” Femoral Stem

    Directory of Open Access Journals (Sweden)

    Thomas B. Pace

    2014-01-01

    Full Text Available This study evaluates the outcomes of 92 hip arthroplasties using a press fit, tapered, split tip, proximally porous ingrowth (CSTi femoral stem (Zimmer Natural Hip in consecutive hip arthroplasty patients followed for an average of ten years postoperatively (range 5–16 years. Patients were functionally and radiographically evaluated using Harris Hip Scores and plain radiographs assessing postarthroplasty groin or thigh pain and radiographic signs of stem subsidence, proximal femoral fixation, stress shielding, and related calcar resorption. At followup of 5–10 years, the incidence of groin pain and thigh pain was 9.1% and 3.6%, respectively. This incidence improved over time. Beyond 10 years of followup, groin pain was 2.7% and thigh pain zero. In 89% of cases, there was solid contact between the calcar and the undersurface of the stem collar. Five cases were revised for instability (5.4%. The Harris Hip Scores and the incidence of thigh or groin pain were very favorable compared to other reported press fit total hip arthroplasty stems and not significantly different across a broad age range. There were no cases of stem loosening of failure of bony ingrowth into the stem.

  4. A Survey of Women's Movement in the 1911 Revolution in the Past Ten Years%近1O年来辛亥革命时期妇女运动研究综述

    Institute of Scientific and Technical Information of China (English)

    李黎明

    2011-01-01

    近10年来,辛亥革命时期的妇女运动研究取得了可喜的进展,在有关宏观性研究以及女子报刊、女子教育、女权思潮、女子参政和人物研究方面均发表了很多有价值的论文,提出了不少有见地的观点。但是,研究中也存在一些问题和不足,需要今后加以改进。%Studies on women's movement during the 1911 Revolution got favorable achievement in the past ten years. A large number of valuable papers on macro studies, and in women newspapers, women' s education, feminist trend, women' s participation character studies were published, and significant views were proposed. However, questions and shortcomings in studies still exist, and requires for further improvement.

  5. Ten Years after the International Committee of Medical Journal Editors' Clinical Trial Registration Initiative, One Quarter of Phase 3 Pediatric Epilepsy Clinical Trials Still Remain Unpublished: A Cross Sectional Analysis.

    Directory of Open Access Journals (Sweden)

    Anette Lampert

    Full Text Available Although selective reporting of clinical trial results introduces bias into evidence based clinical decision making, publication bias in pediatric epilepsy is unknown today. Since there is a considerable ambiguity in the treatment of an important and common clinical problem, pediatric seizures, we assessed the public availability of results of phase 3 clinical trials that evaluated treatments of seizures in children and adolescents as a surrogate for the extent of publication bias in pediatric epilepsy.We determined the proportion of published and unpublished study results of phase 3 clinical trials that were registered as completed on ClinicalTrials.gov. We searched ClinicalTrials.gov, PubMed, and Google Scholar for publications and contacted principal investigators or sponsors. The analysis was performed according to STROBE criteria.Considering studies that were completed before 2014 (N = 99, 75 (76% pediatric phase 3 clinical trials were published but 24 (24% remained unpublished. The unpublished studies concealed evidence from 4,437 patients. Mean time-to-publication was 25 SD ± 15.6 months, more than twice as long as mandated.Ten years after the ICMJE's clinical trials registration initiative there is still a considerable amount of selective reporting and delay of publication that potentially distorts the body of evidence in the treatment of pediatric seizures.

  6. A research of Chinese table tennis project competition pattern characteristic in the last ten years%近十年我国乒乓球项目竞技格局特征研究

    Institute of Scientific and Technical Information of China (English)

    王军; 杨忠明

    2015-01-01

    采用文献资料、数理统计等方法,对近十年我国乒乓球项目竞技格局进行研究,结果表明:我国乒乓球男子项目中竞技实力不断提升的是北京和解放军队,竞技实力在下降的是广东、上海、黑龙江和江苏队;女子项目中竞技实力在减弱的是河北和辽宁队,竞技实力逐步提升的是山东队,竞技实力稳中稍降的是北京队。%By using the methods of literature, mathematical statistics and others, Chinese table tennis project has been studied in recent ten years . The results show that Beijing and the People’s Liberation Army teams are constantly improving in Chinese man’s table tennis competitive strength, while Guangdong, Shanghai, Heilongjiang and Jiangsu teams are decreasing. In woman’s events, Hebei and Liaoning teams are decreasing too;the Shandong team is gradually raising, and the Beijing team is slightly fallen in stability.

  7. 上海市体外诊断试剂生产企业十年发展及监管情况回顾%Ten Years Review of the Development and Administration of Shanghai IVD Reagents

    Institute of Scientific and Technical Information of China (English)

    刘歆; 徐凤玲; 岳伟

    2011-01-01

    This article reviews the development and administration of Shanghai IVDs(ln Vitro Diagnostics) manufactures by analyzing the administration and history of the regulation of IVDs in ten years.It is to find out the problems in the administration of IVDs manufactures and products, and to make suggestions for improvements.%通过对上海市体外诊断试剂生产企业自2000年至2010年十年内企业和产品在数量、种类、规模.生产方式等方面的监管数据进行统计和分析,阐述了体外诊断试剂作为医疗器械特殊品种监管的历程及发展现状旨在找出体外诊断试剂目前监管中存在的问题提出未来监管的重点以及改进的建议.

  8. Molecular Diagnosis of Cystic Fibrosis.

    Science.gov (United States)

    Deignan, Joshua L; Grody, Wayne W

    2016-01-01

    This unit describes a recommended approach to identifying causal genetic variants in an individual suspected of having cystic fibrosis. An introduction to the genetics and clinical presentation of cystic fibrosis is initially presented, followed by a description of the two main strategies used in the molecular diagnosis of cystic fibrosis: (1) an initial targeted variant panel used to detect only the most common cystic fibrosis-causing variants in the CFTR gene, and (2) sequencing of the entire coding region of the CFTR gene to detect additional rare causal CFTR variants. Finally, the unit concludes with a discussion regarding the analytic and clinical validity of these approaches.

  9. Influence of Hepatic Inflammation on FibroScan Findings in Diagnosing Fibrosis in Patients with Chronic Hepatitis B.

    Science.gov (United States)

    Zeng, Xianghua; Xu, Cheng; He, Dengming; Zhang, Huiyan; Xia, Jie; Shi, Dairong; Kong, Lingjun; He, Xiaoqin; Wang, Yuming

    2015-06-01

    Hepatic inflammation may affect the performance of FibroScan. This prospective study investigated the influence of hepatic inflammation on liver stiffness measurement (LSM) values by assessing FibroScan and liver biopsy findings in 325 patients with chronic hepatitis B. Liver fibrosis and inflammation were classified into five stages (S0-S4) and grades (G0-G4) according to the Scheuer scoring system. LSM values were correlated with fibrosis stage and inflammation grade (r = 0.479, p inflammation grade, no significant differences were found between patients with significant fibrosis (S2-S4) (p > 0.05). For inflammation grades G0, G1, G2 and G3, areas under receiver operating characteristic curves of FibroScan for significant fibrosis were 0.8267 (p Inflammation has a significant influence on LSM values in patients with chronic hepatitis B with mild fibrosis, but not in those with significant fibrosis.

  10. [Cystic fibrosis in 2008].

    Science.gov (United States)

    Durieu, I; Josserand, R Nove

    2008-11-01

    To describe the epidemiological, physiopathological, clinical and therapeutic knowledge concerning cystic fibrosis (CF). Important modifications in the health organization of the care concerning this orphan disease have been implemented in France. The life expectancy has dramatically increased, as well as the knowledge concerning the pathological structure and function of the CFTR gene and protein. This will lead to the development of emerging drug treatments for this lethal disease. The life expectancy is predicted to exceed 40 years for children born in the 2000s. As a result, there has been a tremendous growth of the adult population that reached 40% of the overall approximately 5000 patients included in the CF French registry (Observatoire National de la Mucoviscidose). Lung disease remains the primary cause of morbidity and mortality. The characteristic phenotypic presentation associates bronchial and rhinosinusal symptoms, pancreatic insufficiency and liver disease. Bronchial damage leads to progressive chronic respiratory insufficiency. Diabetes mellitus and osteoporosis frequently appears in adulthood. Neonatal screening has been implemented in France since 2002. It will prevent delayed diagnosis and its deleterious consequences. Some atypical cases of CF presenting only with one or two organ system involvement can be diagnosed in adulthood. Isolated chronic rhinosinusitis, bronchiectasis, congenital bilateral absence of vas deferens, recurrent pancreatitis, allergic bronchopulmonary aspergillosis, and some case of cholangitis may so revealed late form of cystic fibrosis. The health care is organized in cystic fibrosis centres. Despite gene discovery, treatment still remains symptomatic, based on intensive pulmonary and nutritional treatments. Challenges for new treatments are to correct the basic defect, either by gene therapy or by pharmacological modulation of the abnormal physiological processes.

  11. In favour of the definition "adolescents with idiopathic scoliosis": juvenile and adolescent idiopathic scoliosis braced after ten years of age, do not show different end results. SOSORT award winner 2014

    OpenAIRE

    Donzelli, Sabrina; Zaina, Fabio; Lusini, Monia; Minnella, Salvatore; Negrini, Stefano

    2014-01-01

    Background The most important factor discriminating juvenile (JIS) from adolescent idiopathic scoliosis (AIS) is the risk of deformity progression. Brace treatment can change natural history, even when risk of progression is high. The aim of this study was to compare the end of growth results of JIS subjects, treated after 10 years of age, with final results of AIS. Methods Design: prospective observational controlled cohort study nested in a prospective database. Setting: outpatient tertiary...

  12. Nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Marckmann, Peter

    2008-01-01

    that gadolinium-containing contrast agents used for magnetic resonance imaging have an essential causative role in most, if not all, cases of nephrogenic systemic fibrosis. One particular agent, gadodiamide, caused the majority of cases, but gadopentetate dimeglumine has also been implicated in several cases....... Increasingly poor renal function, aberrations in calcium-phosphate metabolism and erythropoietin treatment seem to increase the risk of the disease and its severity. Up to 25-30% of patients with renal failure exposed to gadolinium-based contrast agents may develop nephrogenic systemic disease. The figure...

  13. Cystic fibrosis and sleep.

    Science.gov (United States)

    Katz, Eliot S

    2014-09-01

    Sleep disturbances are frequently observed in cystic fibrosis (CF). The resultant sleep fragmentation, short sleep duration, and gas-exchange abnormalities are postulated to contribute to the neurocognitive, cardiovascular, and metabolic abnormalities associated with CF. There are no outcomes data to establish the optimal procedure for screening and treating CF patients for sleep-related respiratory abnormalities. Therapy with supplemental oxygen and bilevel ventilation are widely considered to be effective in the short term, but there are few evidence-based data to support long-term improvements in morbidity and mortality. Copyright © 2014 Elsevier Inc. All rights reserved.

  14. [Nephrogenic systemic fibrosis].

    Science.gov (United States)

    Cavallini, L; Abaterusso, C; Bedogna, V; Pertica, N; Loschiavo, C; Lupo, A

    2008-01-01

    Nephrogenic systemic fibrosis (NSF) is a new, rare, and severe disease occurring in patients with renal failure who have been exposed to gadolinium. The pathogenesis of NSF is not completely known. In fact, the first warning about a significant relationship between NSF and gadolinium (a contrast medium used in magnetic resonance imaging) was only issued in 2006. No cases of NSF have been reported in Italy to date. A nationwide investigation should therefore be carried out to assess the real prevalence of NSF within the Italian uremic population. Furthermore, we need guidelines to reduce the risk of NSF in renal patients undergoing MRI with contrast medium.

  15. 新世纪10余年黄宗忠先生图书馆学思想述略%Professor Huang Zongzhong' s Thoughts on Library Science in the Last Ten Years

    Institute of Scientific and Technical Information of China (English)

    王晓燕

    2012-01-01

    黄宗忠先生是当代著名图书馆学家、教育学家。近10余年来,他积极开展图书馆学基础理论和体系结构的创新,高度重视当代图书馆现实问题的研究,特别强调图书馆学研究的本土化和专业化,密切关注学习借鉴国外图书馆学理论观念、技术方法和先进经验为我所用,在图书馆学理论、图书馆事业建设等领域提出了一系列独特见解,在我国图书馆界产生了广泛而深远的影响,也为发展和丰富我国图书馆学理论研究做出了重要贡献。%Huang Zongzhong was a famous library scientist and educationist. In the last ten years, he had been active in innovating the basic theory and architecture of library science. He attached great importance to study the practical problems in contemporary libraries, with particular emphasis on the localization and specialization of library science. He paid close attention to learning from for- eign library science theories, concepts, technical approaches and advanced experience. He had given a series of unique insights into the field of library science theory and library construction, making extensive and far-reaching impact in the library circle with his important contributions to theoretical research for the development and enrichment of library science in China.

  16. A Review of Studies of Agro-ecology Compensation in Recent Ten Years%近十年来国内关于农业生态补偿研究综述

    Institute of Scientific and Technical Information of China (English)

    陈海军; 陈刚

    2013-01-01

    The research literatures of agro-ecological compensation in recent ten years were divided into five aspects: mechanism of agro-ecological compensation mechanism, system of agro-ecological compensation, legislation of agro-ecological compensation, standard of agro-ecological compensation, and foreign experience of agro-ecological compensation. And through analyzing, it was found that there are some shortages in the aspects of the basic conceptual definition, application of accounting technology, the localization of foreign experience, argument of area adaptability of default premise and subjects' comprehensive application. Finally, the development tendency and direction of agro-ecology compensation were summarized.%将近十年来国内期刊关于农业生态补偿的研究文献被归纳为以农业生态补偿的机制为中心的探讨、关于农业生态补偿的制度讨论、农业生态补偿的立法研究、对国外经验的借鉴和讨论补偿的核心问题——补偿标准等5个主要方面,进行了回顾与分析,发现目前的研究在基本概念的认识、核算方法的综合应用、国外经验的本土化、默认前提的地区适应性论证、学科综合等方面还存在不足.最后,总结了其发展趋势与方向.

  17. A ten-year surveillance study of carbapenemase-producing Klebsiella pneumoniae in a tertiary care Greek university hospital: predominance of KPC- over VIM- or NDM-producing isolates.

    Science.gov (United States)

    Spyropoulou, Aikaterini; Papadimitriou-Olivgeris, Matthaios; Bartzavali, Christina; Vamvakopoulou, Sophia; Marangos, Markos; Spiliopoulou, Iris; Anastassiou, Evangelos D; Christofidou, Myrto

    2016-03-01

    Resistance patterns and carbapenemase gene presence among Klebsiella pneumoniae isolates from the University General Hospital of Patras, Greece during a ten-year period were analysed under a surveillance programme for multi-drug-resistant bacteria. From 2005 to 2014, K. pneumoniae isolates from clinically significant specimens were identified by the Vitek 2 Advanced Expert System. Antibiotic susceptibility testing was performed by the agar disc diffusion method and Etest. The strains were tested for the presence of blaVIM, blaIMP, blaKPC, blaNDM and blaOXA-48 genes by PCR. PFGE of chromosomal Xbal DNA digests was performed. A total of 3449 K. pneumoniae isolates were recovered during the last decade. Among them, 1668 (48 %) were carbapenemase-producing: 1333 (80%) K. pneumoniae carbapenemase (KPC)-, 286 (17%) Verona imipenemase (VIM), 45 (3%) KPC- and VIM-, and four New Delhi metallo-beta-lactamase (NDM)-producing. Their resistance rates to gentamicin, colistin and tigecycline were 41%, 23% and 16%, respectively. VIM-producing K. pneumoniae were isolated in 2005 and since 2008 have been endemic. KPC-producing K. pneumoniae (KPC-Kp) isolates were introduced in 2008 and until now represent the predominant carbapenemase-producing K. pneumoniae in our institution. PFGE of 97 KPC-Kp strains identified three types: A, 84 (87%); B, 11 (11%); and E, two (2%). Eleven co-producing KPC and VIM K. pneumoniae isolates belonged to PFGE B. The four NDM-positives were classified to type F. The number of K. pneumoniae bacteraemias increased during the study period, which may be solely attributed to the increase of carbapenemase-producing isolates. The threat of carbapenemase-producing K. pneumoniae emphasizes the urgent need for implementation of infection control measures and budgetary allocations to infection control.

  18. Research Overview on English Teaching of Secondary Vocational Education over the Past Ten Years%近十年我国中职英语教学研究综述

    Institute of Scientific and Technical Information of China (English)

    陈咏

    2016-01-01

    通过综述的方式归纳和梳理了近十年来在职业教育类和外语类核心期刊上发表的有关中职英语教学研究的论文,发现十年来我国中职英语教学研究得到了充分重视,主题鲜明,内容丰富。但整体而言,中职英语教学研究者缺乏职业教育的英语课程观、教学观以及对中职学生学习特点的深入研究,鲜有将职业教育教学理论与中职英语教学紧密结合起来的研究,研究内容失衡,方法较为单一,缺乏实证研究。%This review provides a general analysis of English language teaching research of secondary vocational education, which is based on the articles published in core journals on vocational education and foreign language teaching in past ten years. It is found that much focus has been laid on English language teaching research of secondary vocational school with rich content and distinct theme. Overall, the researches neglected the view of English curriculum and English teaching from the domain of vocational education as well as the learning characteristic of the secondary vocational school students. Few research pays attention to the study integrating vocational education and teaching theory with English teaching of secondary vocational education. Problems lie in imbalanced research content and methodology, and the lack of empirical research.

  19. 我国教师课程能力十年研究述评%Research of Teachers'Curriculum Abilities Researches in the Past Ten Years in China:Retrospection and Reflections

    Institute of Scientific and Technical Information of China (English)

    包兵兵; 陈菊

    2014-01-01

    In the past ten years ,researches of teachers'curriculum abilities in China focused on the bas‐ic content ,features ,components ,stages of development ,practical issues and causes ,strategies of promotion and other aspects .Researchers recognized the important role of teachers'curriculum abili‐ties in the new curriculum reform and the professional development of teachers ,and discussed more extensively and deeply ,so as to have actively promoted the teacher's curriculum abilities on the theory and practice in the context of curriculum reform .However ,there are also some problems ,including insufficient concern ,a limited number of research objects ,inadequate theoretical innovation ,and re‐stricted type of research methods .Therefore ,further research is expected .%最近十年,我国研究者对教师课程能力的研究主要集中在教师课程能力的基本内涵、主要特征、构成要素、发展阶段、实践问题及形成原因、提升策略等方面。研究者认识到教师课程能力在新课程改革和教师专业化发展中的重要作用,对其展开了较为广泛而深入的探讨,积极推动了教师课程能力在新课程改革背景下的理论建构与实践研究。但是,我国教师课程能力研究还存在重视程度不够、研究对象窄化、理论创新滞后、研究方法单一等问题,需要展开进一步研究。

  20. Serum markers of liver fibrosis

    DEFF Research Database (Denmark)

    Veidal, Sanne Skovgård; Bay-Jensen, Anne-Christine; Tougas, Gervais

    2010-01-01

    BACKGROUND: Fibrosis is a central histological feature of chronic liver diseases and is characterized by the accumulation and reorganization of the extracellular matrix. The gold standard for assessment of fibrosis is histological evaluation of a percutaneous liver biopsy. Albeit a considerable......-epitopes, may be targeted for novel biochemical marker development in fibrosis. We used the recently proposed BIPED system (Burden of disease, Investigative, Prognostic, Efficacy and Diagnostic) to characterise present serological markers. METHODS: Pubmed was search for keywords; Liver fibrosis, neo......, a systematic use of the neo-epitope approach, i.e. the quantification of peptide epitopes generated from enzymatic cleavage of proteins during extracellular remodeling, may prove productive in the quest to find new markers of liver fibrosis....

  1. Management strategies for liver fibrosis.

    Science.gov (United States)

    Altamirano-Barrera, Alejandra; Barranco-Fragoso, Beatriz; Méndez-Sánchez, Nahum

    2017-01-01

    Liver fibrosis resulting from chronic liver injury are major causes of morbidity and mortality worldwide. Among causes of hepatic fibrosis, viral infection is most common (hepatitis B and C). In addition, obesity rates worldwide have accelerated the risk of liver injury due to nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Also liver fibrosis is associated with the consumption of alcohol, or autoimmune hepatitis and chronic cholangiophaties. The response of hepatocytes to inflammation plays a decisive role in the physiopathology of hepatic fibrosis, which involves the recruitment of both pro- and anti-inflammatory cells such as monocytes and macrophages. As well as the production of other cytokines and chemokines, which increase the stimulus of hepatic stellate cells by activating proinflammatory cells. The aim of this review is to identify the therapeutic options available for the treatment of the liver fibrosis, enabling the prevention of progression when is detected in time.

  2. Liver Fibrosis in HIV Patients Receiving a Modern cART

    Science.gov (United States)

    Mohr, Raphael; Schierwagen, Robert; Schwarze-Zander, Carolynne; Boesecke, Christoph; Wasmuth, Jan-Christian; Trebicka, Jonel; Rockstroh, Jürgen Kurt

    2015-01-01

    Abstract Liver-related death in human immunodeficiency virus (HIV)-infected individuals is about 10 times higher compared with the general population, and the prevalence of significant liver fibrosis in those with HIV approaches 15%. The present study aimed to assess risk factors for development of hepatic fibrosis in HIV patients receiving a modern combination anti-retroviral therapy (cART). This cross-sectional prospective study included 432 HIV patients, of which 68 (16%) patients were anti-hepatitis C virus (HCV) positive and 23 (5%) were HBsAg positive. Health trajectory including clinical characteristics and liver fibrosis stage assessed by transient elastography were collected at inclusion. Liver stiffness values >7.1 kPa were considered as significant fibrosis, while values >12.5 kPa were defined as severe fibrosis. Logistic regression and Cox regression uni- and multivariate analyses were performed to identify independent factors associated with liver fibrosis. Significant liver fibrosis was detected in 10% of HIV mono-infected, in 37% of HCV co-infected patients, and in 18% of hepatitis B virus co-infected patients. The presence of diabetes mellitus (odds ratio [OR] = 4.6) and FIB4 score (OR = 2.4) were independently associated with presence of significant fibrosis in the whole cohort. Similarly, diabetes mellitus (OR = 5.4), adiposity (OR = 4.6), and the FIB4 score (OR = 3.3) were independently associated with significant fibrosis in HIV mono-infected patients. Importantly, cumulative cART duration protected, whereas persistent HIV viral replication promoted the development of significant liver fibrosis along the duration of HIV infection. Our findings strongly indicate that besides known risk factors like metabolic disorders, HIV may also have a direct effect on fibrogenesis. Successful cART leading to complete suppression of HIV replication might protect from development of liver fibrosis. PMID:26683921

  3. Idiopathic pulmonary fibrosis.

    Science.gov (United States)

    Xaubet, Antoni; Ancochea, Julio; Molina-Molina, María

    2017-02-23

    Idiopathic pulmonary fibrosis is a fibrosing interstitial pneumonia associated with the radiological and/or histological pattern of usual interstitial pneumonia. Its aetiology is unknown, but probably comprises the action of endogenous and exogenous micro-environmental factors in subjects with genetic predisposition. Its diagnosis is based on the presence of characteristic findings of high-resolution computed tomography scans and pulmonary biopsies in absence of interstitial lung diseases of other aetiologies. Its clinical evolution is variable, although the mean survival rate is 2-5 years as of its clinical presentation. Patients with idiopathic pulmonary fibrosis may present complications and comorbidities which modify the disease's clinical course and prognosis. In the mild-moderate disease, the treatment consists of the administration of anti-fibrotic drugs. In severe disease, the best therapeutic option is pulmonary transplantation. In this paper we review the diagnostic and therapeutic aspects of the disease. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  4. Role of vitamin A in liver fibrosis

    NARCIS (Netherlands)

    Knook, D.L.; Bosma, A.; Seifert, W.F.

    1995-01-01

    The relationship between vitamin A and liver fibrosis was studied with a CCl4-induced fibrosis model in rats. Depending on the time of administration, vitamin A can potentiate or reduce fibrosis: when present during CCl4-treatment parenchymal cell damage and fibrosis were enhanced, whereas vitamin A

  5. Gastroesophageal Reflux Disease in Children with Cystic Fibrosis.

    Science.gov (United States)

    Dziekiewicz, Marcin A; Banaszkiewicz, Aleksandra; Urzykowska, Agnieszka; Lisowska, Aleksandra; Rachel, Marta; Sands, Dorota; Walkowiak, Jaroslaw; Radzikowski, Andrzej; Albrecht, Piotr

    2015-01-01

    Previously published studies have indicated that gastroesophageal reflux (GER) disease is common in pediatric patients with cystic fibrosis. The aim of the present study was to get insight into the incidence of GER and to characterize the nature of reflux episodes in children with cystic fibrosis. This was a multicenter, prospective study of children with cystic fibrosis older than 18 months. Forty four consecutive patients (22 boys, mean age 10.4 ± 3.6, range 3.0-17.8 years) were enrolled into the study. All patients underwent 24 h pH-impedance monitoring. GER were classified according to the widely recognized criteria as an acid, weakly acid, weakly alkaline, or proximal. The pH-impedance trace was considered abnormal when acid exposure was >6 %. GER was diagnosed in 24/44 (54.5 %) children. A total of 1585 (median 35, range 7-128) reflux episodes were detected; 1199 (75.6 %) were acidic, 382 (24.1 %) weakly acidic, and 4 (0.3 %) weakly alkaline. Six hundred and ninety-one (43.6 %) reflux episodes reached the proximal esophagus. In 14/44 patients typical GER symptoms were present. We conclude that the incidence of GER in children with cystic fibrosis is very high. In the majority of patients typical GER symptoms are absent. Therefore, diagnostic procedures should be considered, regardless of lacking symptoms. Although acid reflux episodes predominate in children with cystic fibrosis, classical pH-metry may not constitute a sufficient diagnostic method in this population because of a relatively high number of proximal reflux episodes. Such episodes also indicate an increased risk for aspiration. The pH-impedance diagnostic measurement is advocated when suspecting GER in children with cystic fibrosis.

  6. O pessegueiro em pomar compacto. IX. dez anos de produção de cultivares sob poda drástica bienal The peach meadow orchard system. IX. yield of cultivars during ten years on biennial drastic pruning

    Directory of Open Access Journals (Sweden)

    Wilson Barbosa

    1999-01-01

    Full Text Available O objetivo deste trabalho foi comparar o desenvolvimento vegetativo e reprodutivo de quatorze cultivares e seleções de pessegueiro (Prunus persica L. Batsch e nectarineira cultivadas no espaçamento de 4 x 1,5 m (1.667 pl/ha, sob poda drástica bienal da copa. Pelos resultados obtidos no decênio 1986-95, verificou-se que as cultivares e seleções mais produtivas foram (número e kg de frutos/planta respectivamente: Aurora-1 (112; 9,2, IAC 680-178 (94; 8,5, IAC 680-13 (95; 8,1, Talismã (99; 8,1, Régis (98; 7,8 e Flordaprince (91; 7,7. No ano agrícola de 1995, as variáveis analisadas, área da secção transversal do tronco, área da folha, número e massa dos frutos por cm² de tronco, apresentaram diferenciação estatística entre cultivares e seleções. A poda drástica bienal da copa ocasionou, tanto em material precoce quanto mediano, diminuição de produção a cada duas safras, não chegando, porém, a prejudicar a produtividade média do pomar.Fourteen peach (Prunus persica L. Batsch and nectarine cultivars and selections, budded on Okinawa rootstock, were grown under the meadow orchard system, with biennial drastic pruning at 4 x 1.5 m spacing. Results obtained during ten years of experiments (1986-95 clearly indicate that 'Aurora-1', IAC 680-178, IAC 680-13, 'Talismã', 'Régis' and 'Flordaprince' peaches were the best, with an average yield (fruits per tree of 112, 9.2; 94, 8.5; 95, 8.1; 99, 8.1; 98, 7.8 and 91, 7.7 number and kg/tree respectively. The biennial drastic pruning decreased the yield of trees every two years, without affecting the average decennial productivity. In 1995, data on trunk cross-sectional area, fruits and mass per cm² of trunk and leaf area presented significant differences among cultivars and selections.

  7. Nutritional Issues in Cystic Fibrosis.

    Science.gov (United States)

    Solomon, Missale; Bozic, Molly; Mascarenhas, Maria R

    2016-03-01

    The importance of maintaining adequate nutrition in patients with cystic fibrosis has been well known for the past 3 decades. Achieving normal growth and maintaining optimal nutrition is associated with improved lung function. Comprehensive and consistent nutritional assessments at regular intervals can identify those at risk of nutritional failure and uncover micronutrient deficiencies contributing to malnutrition. Management of malnutrition in cystic fibrosis should follow a stepwise approach to determine the causes and comorbidities and to develop a nutritional plan. Nutritional management is crucial at every stage in a person's life with cystic fibrosis and remains a cornerstone of management.

  8. Epigenetic regulation in cardiac fibrosis

    Institute of Scientific and Technical Information of China (English)

    Li-Ming; Yu; Yong; Xu

    2015-01-01

    Cardiac fibrosis represents an adoptive response in the heart exposed to various stress cues. While resolution of the fibrogenic response heralds normalization of heart function, persistent fibrogenesis is usually associated with progressive loss of heart function and eventually heart failure. Cardiac fibrosis is regulated by a myriad of factors that converge on the transcription of genes encoding extracellular matrix proteins, a process the epigenetic machinery plays a pivotal role. In this minireview, we summarize recent advances regarding the epigenetic regulation of cardiac fibrosis focusing on the role of histone and DNA modifications and non-coding RNAs.

  9. Nephrogenic systemic fibrosis.

    LENUS (Irish Health Repository)

    Kennedy, C

    2010-11-05

    Nephroaenic systemic fibrosis (NSF) is a potentiallv fatal dermatiological condition found exclusively in patients with advanced renal I failure. There is minimal literature regarding the epidemiology and outcomes of patients with NSF in Ireland. A retrospective chart review was performed for all patients with NSF in Ireland. Ireland\\'s experience with the disease was examined in light of international reports. There have been three cases of NSF in Ireland; an area which serves 1915 dialysis patients--giving a point prevalence among Irish end-stage kidney disease patients of 0.002. There was a large variation in disease severity between the three patients. All three patients had significant exposure to gadolinium chelate. Caution with gadolinium administration must be exercised in patients with advanced renal failure.

  10. Profile of cystic fibrosis

    Directory of Open Access Journals (Sweden)

    Mona M. El-Falaki

    2014-09-01

    Full Text Available It was generally believed that Cystic fibrosis (CF is rare among Arabs; however, the few studies available from Egypt and other Arabic countries suggested the presence of many undiagnosed patients. The aim of the present study was to determine the frequency of CF patients out of the referred cases in a single referral hospital in Egypt. A total of 100 patients clinically suspected of having CF were recruited from the CF clinic of the Allergy and Pulmonology Unit, Children’s Hospital, Cairo University, Egypt, throughout a 2 year period. Sweat chloride testing was done for all patients using the Wescor macroduct system for collection of sweat. Quantitative analysis for chloride was then done by the thiocyanate colorimetric method. Patients positive for sweat chloride (⩾60 mmol/L were tested for the ΔF508 mutation using primer specific PCR for cystic fibrosis transmembrane conductance regulator (CFTR gene. Thirty-six patients (36% had a positive sweat chloride test. The main clinical presentations in patients were chronic cough in 32 (88.9%, failure to thrive in 27 (75%, steatorrhea in 24 (66.7%, and hepatobiliary involvement in 5 (13.9%. Positive consanguinity was reported in 50% of CF patients. Thirty-two patients were screened for ΔF508 mutation. Positive ΔF508 mutation was detected in 22 (68.8% patients, 8 (25% were homozygous, 14 (43.8% were heterozygous, and 10 (31.3% tested were negative. CF was diagnosed in more than third of patients suspected of having the disease on clinical grounds. This high frequency of CF among referred patients indicates that a high index of suspicion and an increasing availability of diagnostic tests lead to the identification of a higher number of affected individuals.

  11. Preliminary investigation of diagnosis and treatment of pulmonary embolism in Chongqing in recent ten years%重庆市近10年肺栓塞诊治情况初步调查

    Institute of Scientific and Technical Information of China (English)

    古正凤; 韩晓黎; 陈虹; 重庆市PTE-DVT防治协作组

    2015-01-01

    Objective To investigate the status of diagnosis and treatment of pulmonary embolism in hospitals of Chongqing in recent ten years in order to provide evidences for the rational organization of pulmonary embolism training and improvement of the level of pulmonary embolism diagnosis and treatment.Methods Samples from 30 hospitals in Chongqing (15 tertiary hospitals,15 second-class hospitals) by convenience sampling method were investigated.The investigation included number of patients with pulmonary embolism from 2003 to 2012,medical conditions,prevention and screening of pulmonary embolism.Results ①The total number of pulmonary embolism diagnosis cases in nearly ten years was 703 (512 cases in tertiary hospitals,191 cases in second-class hospitals),of whom 581 cases were diagnosed in clinic,122 cases were confirmed.The definite diagnosis rate was 17.35%.②With the time,pulmonary embolism diagnosis cases increased gradually,dramatically increased in 2009-2012.③ The unmber of hospitals in which pulmonary embolism could be diagnosed had increased year by year except six hospitals.④ All of the investigated hospitals could carry out biochemical and imaging examinations such as D-dimer,blood gas analysis,myocardial injury markers,activated partial thromboplastin time,international normalized ratio,lower limb vascular ultrasound,cardiac ultrasound,and enhancement CT.All the investigated hospitals had the essential medicines,such as heparin,low molecular heparin,warfarin,and urokinase.⑤17 hospitals could conduct CT pulmonary angiography,including eight hospitals for clinical diagnosis.⑥The eight investigated hospitals conducted pulmonary embolism risk assessment with relevant scale table in some departments.Conclusions The consciousness of pulmonary embolism diagnosis has been gradually improved for the most hospital medical staffs from 2003 to 2012 in Chongqing,but the consciousness of prevention and screening high-risk patients with pulmonary embolism is

  12. ATLAS Detector Upgrade Prospects

    Science.gov (United States)

    Dobre, M.; ATLAS Collaboration

    2017-01-01

    After the successful operation at the centre-of-mass energies of 7 and 8 TeV in 2010-2012, the LHC was ramped up and successfully took data at the centre-of-mass energies of 13 TeV in 2015 and 2016. Meanwhile, plans are actively advancing for a series of upgrades of the accelerator, culminating roughly ten years from now in the high-luminosity LHC (HL-LHC) project, which will deliver of the order of five times the LHC nominal instantaneous luminosity along with luminosity levelling. The ultimate goal is to extend the dataset from about few hundred fb ‑1 expected for LHC running by the end of 2018 to 3000 fb ‑1 by around 2035 for ATLAS and CMS. The challenge of coping with the HL-LHC instantaneous and integrated luminosity, along with the associated radiation levels, requires further major changes to the ATLAS detector. The designs are developing rapidly for a new all-silicon tracker, significant upgrades of the calorimeter and muon systems, as well as improved triggers and data acquisition. ATLAS is also examining potential benefits of extensions to larger pseudorapidity, particularly in tracking and muon systems. This report summarizes various improvements to the ATLAS detector required to cope with the anticipated evolution of the LHC luminosity during this decade and the next. A brief overview is also given on physics prospects with a pp centre-of-mass energy of 14 TeV.

  13. [Lung physiotherapy in cystic fibrosis].

    Science.gov (United States)

    Gursli, S; Haanaes, O C

    1991-02-28

    This article is intended as a brief practical guide for physicians and physiotherapists concerned with the treatment of cystic fibrosis. Physiotherapeutic techniques for the treatment of chest diseases have been developed and modified as advances have taken place in the medical management of cystic fibrosis. The article describes forced expiratory technique, positive expiratory pressure, postural drainage, autogenic drainage and other techniques. Patients with cystic fibrosis live longer and have a better quality of life than ever before, but progressive deterioration of lung function will always be their most serious problem. Physical activity and chest physiotherapy are essential parts of all treatment regimens for cystic fibrosis. It is important to realize that the physiotherapist is a very important member of the team which includes nurses, physicians-and the patient.

  14. Pulmonary fibrosis associated with nabumetone.

    OpenAIRE

    Morice, A.; Atherton, A.; GLEESON, F; Stewart, S.

    1991-01-01

    A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone. Resolution of symptoms, physical signs and radiographic changes followed drug withdrawal and steroid therapy.

  15. Fibrosis quística

    OpenAIRE

    Arturo Solís-Moya; José Pablo Gutiérrez-S

    2003-01-01

    Enfermedades Raras en Asturias. Dirección General de Salud Pública y Participación. Informes breves 09 Cystic fibrosis is a multisystem disease generates the formation and accumulation of viscous mucus that affects everything lungs, digestive system including liver and pancreas. Formerly known as mucoviscidosis or cystic fibrosis pancreas. Este proyecto ha sido financiado a cargo de los fondos para la cohesión territorial 2010 del Ministerio de Sanidad y Política Socia...

  16. Fibrosis quística

    OpenAIRE

    Arturo Solís-Moya; José Pablo Gutiérrez-S

    2014-01-01

    Enfermedades Raras en Asturias. Dirección General de Salud Pública y Participación. Informes breves 09 Cystic fibrosis is a multisystem disease generates the formation and accumulation of viscous mucus that affects everything lungs, digestive system including liver and pancreas. Formerly known as mucoviscidosis or cystic fibrosis pancreas. Este proyecto ha sido financiado a cargo de los fondos para la cohesión territorial 2010 del Ministerio de Sanidad y Política Socia...

  17. Alveolar inflammation in cystic fibrosis

    DEFF Research Database (Denmark)

    Ulrich, Martina; Worlitzsch, Dieter; Viglio, Simona

    2010-01-01

    BACKGROUND: In infected lungs of the cystic fibrosis (CF) patients, opportunistic pathogens and mutated cystic fibrosis transmembrane conductance regulator protein (CFTR) contribute to chronic airway inflammation that is characterized by neutrophil/macrophage infiltration, cytokine release...... accumulated in type II alveolar epithelial cells, lacking CFTR. P. aeruginosa organisms were rarely present in inflamed alveoli. CONCLUSIONS: Chronic inflammation and remodeling is present in alveolar tissues of the CF lung and needs to be addressed by anti-inflammatory therapies....

  18. Predictive 5-Year Survivorship Model of Cystic Fibrosis

    Science.gov (United States)

    Liou, Theodore G.; Adler, Frederick R.; FitzSimmons, Stacey C.; Cahill, Barbara C.; Hibbs, Jonathan R.; Marshall, Bruce C.

    2007-01-01

    The objective of this study was to create a 5-year survivorship model to identify key clinical features of cystic fibrosis. Such a model could help researchers and clinicians to evaluate therapies, improve the design of prospective studies, monitor practice patterns, counsel individual patients, and determine the best candidates for lung transplantation. The authors used information from the Cystic Fibrosis Foundation Patient Registry (CFFPR), which has collected longitudinal data on approximately 90% of cystic fibrosis patients diagnosed in the United States since 1986. They developed multivariate logistic regression models by using data on 5,820 patients randomly selected from 11,630 in the CFFPR in 1993. Models were tested for goodness of fit and were validated for the remaining 5,810 patients for 1993. The validated 5-year survivorship model included age, forced expiratory volume in 1 second as a percentage of predicted normal, gender, weight-for-age z score, pancreatic sufficiency, diabetes mellitus, Staphylococcus aureus infection, Burkerholderia cepacia infection, and annual number of acute pulmonary exacerbations. The model provides insights into the complex nature of cystic fibrosis and supplies a rigorous tool for clinical practice and research. PMID:11207152

  19. New and emerging targeted therapies for cystic fibrosis.

    Science.gov (United States)

    Quon, Bradley S; Rowe, Steven M

    2016-03-30

    Cystic fibrosis (CF) is a monogenic autosomal recessive disorder that affects about 70,000 people worldwide. The clinical manifestations of the disease are caused by defects in the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The discovery of the CFTR gene in 1989 has led to a sophisticated understanding of how thousands of mutations in the CFTR gene affect the structure and function of the CFTR protein. Much progress has been made over the past decade with the development of orally bioavailable small molecule drugs that target defective CFTR proteins caused by specific mutations. Furthermore, there is considerable optimism about the prospect of gene replacement or editing therapies to correct all mutations in cystic fibrosis. The recent approvals of ivacaftor and lumacaftor represent the genesis of a new era of precision medicine in the treatment of this condition. These drugs are having a positive impact on the lives of people with cystic fibrosis and are potentially disease modifying. This review provides an update on advances in our understanding of the structure and function of the CFTR, with a focus on state of the art targeted drugs that are in development.

  20. A comparison of MR elastography and {sup 31}P MR spectroscopy with histological staging of liver fibrosis

    Energy Technology Data Exchange (ETDEWEB)

    Godfrey, Edmund M. [St James' Hospital, Leeds (United Kingdom); St James' Hospital, Department of Radiology, Leeds (United Kingdom); Patterson, Andrew J.; Priest, Andrew N.; Davies, Susan E.; Joubert, Ilse; Krishnan, Anant S.; Shaw, Ashley S.; Alexander, Graeme J.; Allison, Michael E.; Griffiths, William J.H.; Gimson, Alexander E.S. [Addenbrooke' s Hospital, Cambridge (United Kingdom); Griffin, Nyree [St Thomas' s Hospital, London (United Kingdom); Lomas, David J. [University of Cambridge, Department of Radiology, Cambridge (United Kingdom)

    2012-12-15

    Conventional imaging techniques are insensitive to liver fibrosis. This study assesses the diagnostic accuracy of MR elastography (MRE) stiffness values and the ratio of phosphomonoesters (PME)/phosphodiesters (PDE) measured using {sup 31}P spectroscopy against histological fibrosis staging. The local research ethics committee approved this prospective, blinded study. A total of 77 consecutive patients (55 male, aged 49 {+-} 11.5 years) with a clinical suspicion of liver fibrosis underwent an MR examination with a liver biopsy later the same day. Patients underwent MRE and {sup 31}P spectroscopy on a 1.5 T whole body system. The liver biopsies were staged using an Ishak score for chronic hepatitis or a modified NAS fibrosis score for fatty liver disease. MRE increased with and was positively associated with fibrosis stage (Spearman's rank = 0.622, P < 0.001). PME/PDE was not associated with fibrosis stage (Spearman's rank = -0.041, p = 0.741). Area under receiver operating curves for MRE stiffness values were high (range 0.75-0.97). The diagnostic utility of PME/PDE was no better than chance (range 0.44-0.58). MRE-estimated liver stiffness increases with fibrosis stage and is able to dichotomise fibrosis stage groupings. We did not find a relationship between {sup 31}P MR spectroscopy and fibrosis stage. circle Magnetic resonance elastography (MRE) and MR spectroscopy can both assess the liver. (orig.)

  1. Cytokines in human lung fibrosis.

    Science.gov (United States)

    Martinet, Y; Menard, O; Vaillant, P; Vignaud, J M; Martinet, N

    1996-01-01

    Fibrosis is a pathological process characterized by the replacement of normal tissue by mesenchymal cells and the extracellular matrix produced by these cells. The sequence of events leading to fibrosis of an organ involves the subsequent processes of injury with inflammation and disruption of the normal tissue architecture, followed by tissue repair with accumulation of mesenchymal cells in the area of derangement. The same sequence of events occurs in wound healing with normal granulation tissue and scar formation, but, while normal scar formation is very localized and transient, in contrast, in fibrosis, the repair process is exaggerated and usually widespread and can be chronic. Inflammatory cells (mainly mononuclear phagocytes), platelets, endothelial cells, and type II pneumocytes play a direct and indirect role in tissue injury and repair. The evaluation of three human fibrotic lung diseases, two diffuse [idiopathic pulmonary fibrosis (IPF), and the adult respiratory distress syndrome (ARDS)], and one focal (tumor stroma in lung cancer), has shown that several cytokines participate to the local injury and inflammatory reaction [interleukin-1 (IL-1), interleukin-8 (IL-8), monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha)], while other cytokines are involved in tissue repair and fibrosis [platelet-derived growth factor (PDGF), insulin-like growth factor-1 (IGF-1), transforming growth factor-beta (TGF-beta), and basic-fibroblast growth factor (b-FGF)]. A better understanding of the cytokines and cytokine networks involved in lung fibrosis leads to the possibility of new therapeutic approaches.

  2. Therapeutic targets in liver fibrosis.

    Science.gov (United States)

    Fallowfield, Jonathan A

    2011-05-01

    Detailed analysis of the cellular and molecular mechanisms that mediate liver fibrosis has provided a framework for therapeutic approaches to prevent, slow down, or even reverse fibrosis and cirrhosis. A pivotal event in the development of liver fibrosis is the activation of quiescent hepatic stellate cells (HSCs) to scar-forming myofibroblast-like cells. Consequently, HSCs and the factors that regulate HSC activation, proliferation, and function represent important antifibrotic targets. Drugs currently licensed in the US and Europe for other indications target HSC-related components of the fibrotic cascade. Their deployment in the near future looks likely. Ultimately, treatment strategies for liver fibrosis may vary on an individual basis according to etiology, risk of fibrosis progression, and the prevailing pathogenic milieu, meaning that a multiagent approach could be required. The field continues to develop rapidly and starts to identify exciting potential targets in proof-of-concept preclinical studies. Despite this, no antifibrotics are currently licensed for use in humans. With epidemiological predictions for the future prevalence of viral, obesity-related, and alcohol-related cirrhosis painting an increasingly gloomy picture, and a shortfall in donors for liver transplantation, the clinical urgency for new therapies is high. There is growing interest from stakeholders keen to exploit the market potential for antifibrotics. However, the design of future trials for agents in the developmental pipeline will depend on strategies that enable equal patient stratification, techniques to reliably monitor changes in fibrosis over time, and the definition of clinically meaningful end points.

  3. Update on the debate about the existence and utility of the Big Five: a ten-year follow-up on Carroll's "the Five-Factor Personality Model: how complete and satisfactory is it?

    Science.gov (United States)

    Merenda, Peter F

    2008-12-01

    This paper is a follow-up comment on John B. Carroll's critique of the Big Five Model and his suggestion years ago on how to design and conduct research properly on the structure of personality and its assessment. The status of research on personality factor models is discussed, and conclusions are reached regarding the likely consequences and further prospects of the failure of personality theorists and practitioners to follow through on Carroll's poignant suggestion for required effort.

  4. Acoustic radiation force imaging sonoelastography for noninvasive staging of liver fibrosis

    Institute of Scientific and Technical Information of China (English)

    Carmen Fierbinteanu-Braticevici; Dan Andronescu; Radu Usvat; Dragos Cretoiu; Cristian Baicus; Gabriela Marinoschi

    2009-01-01

    AIM: To investigate the diagnostic accuracy of acoustic radiation force impulse (ARFI) imaging as a noninvasive method for the assessment of liver fibrosis in chronic hepatitis C (CHC) patients.METHODS: We performed a prospective blind comparison of ARFI elastography, APRI index and FibroMax in a consecutive series of patients who underwent liver biopsy for CHC in University Hospital Bucharest. Histopathological staging of liver fibrosis according to the METAVIR scoring system served as the reference. A total of 74 patients underwent ARFI elastography, APRI index, FibroMax and successful liver biopsy.RESULTS: The noninvasive tests had a good correlation with the liver biopsy results. The most powerful test in predicting fibrosis was ARFI elastography. The diagnostic accuracy of ARFI elastography, expressed as area under receiver operating characteristic curve (AUROC) had a validity of 90.2% (95% CI AUROC =0.831-0.972, P < 0.001) for the diagnosis of significant fibrosis (F ≥ 2). ARFI sonoelastography predicted even better F3 or F4 fibrosis (AUROC = 0.993, 95% CI =0.979-1).CONCLUSION: ARFI elastography had very good accuracy for the assessment of liver fibrosis and was superior to other noninvasive methods (APRI Index,FibroMax) for staging liver fibrosis.

  5. Dez anos de heterocontrole da fluoretação de águas em Chapecó, Estado de Santa Catarina, Brasil Ten years of external control over water fluoridation in Chapecó, Santa Catarina State, Brazil

    Directory of Open Access Journals (Sweden)

    Mirvaine Panizzi

    2008-09-01

    Full Text Available O objetivo deste estudo foi analisar a concentração de flúor na água de abastecimento público em Chapecó, Santa Catarina, Brasil, no período de 1995 a 2005 e, adicionalmente, avaliar a efetividade de uma intervenção ocorrida em 2003 na qualidade da fluoretação. Foram analisadas 989 amostras de água. Para adequação da concentração de flúor as amostras foram classificadas obedecendo a três critérios utilizados no Brasil. Uma intervenção político-jurídica foi realizada pela municipalidade no ano de 2003. A fim de avaliar a tendência da fluoretação ao longo de todo período e antes e depois da intervenção, utilizou-se o procedimento de Prais-Winsten. Nos dez anos analisados, o sistema de fluoretação de águas apresentou 46%, 32% e 43% de amostras adequadas, dependendo do critério adotado. Previamente à intervenção municipal, a proporção de amostras adequadas foi de 40%, 26% e 36%, aumentando para 63%, 49% e 61% após intervenção, segundo os diferentes critérios de análise. Verificou-se uma melhora na adequação da concentração de flúor após a intervenção municipal. Recomenda-se a continuidade da vigilância da fluoretação de águas, considerando-a processual e de caráter permanente.This study aimed to analyze fluoride concentration in the public water supply in Chapecó, Santa Catarina State, Brazil, from 1995 to 2005 and to assess the effectiveness of a fluoridation quality intervention in 2003. A total of 989 water samples were analyzed. Fluoride concentrations were classified according to three different criteria used in Brazil. The city conducted a political and legal intervention in 2003. The Prais-Winsten procedure was used to evaluate the fluoride concentrations over time. In the ten years, the water fluoridation system showed 46%, 32%, and 43% of adequate samples, depending on the criterion. Prior to the municipal intervention, the proportion of adequate samples was 40%, 26%, and 36

  6. Qualitative postural analysis among boys and girls of seven to ten years of age Análise postural qualitativa entre meninos e meninas de sete a dez anos de idade

    Directory of Open Access Journals (Sweden)

    PJ Penha

    2008-10-01

    Full Text Available BACKGROUND: Postural abnormalities are often found in children. At this stage of life, posture undergoes many adjustments and adaptations due to body changes. Objective: To qualitatively identify the postural abnormalities which occur most frequently among children aged OBJECTIVE: Reven and ten years, comparing boys and girls, and to evaluate these subjects' lumbar flexibility. METHODS: One hundred and ninety-one children were photographed in the sagittal and frontal planes. The variables analyzed were: ankle (valgus and varus, tibiotarsal angle (opened and closed, knee (hyperextension and semiflexion, valgus and varus, pelvis (anteversion and retroversion; lateral pelvic inclination, trunk (antepulsion and retropulsion, lumbar spine (hyperlordosis and rectification, thoracic spine (hyperkyphosis and rectification, cervical spine (hyperlordosis and rectification, scoliosis, shoulder (imbalance and protraction, scapula (winged, abducted and adducted and head (tilt and protraction. The lumbar flexibility was assessed using Schöber's index. RESULTS: The boys had greater incidence of winged scapula, shoulder imbalance, protraction of shoulders and head and cervical hyperlordosis than the girls did. Conversely, the girls had greater incidence of head tilt and larger Schöber index values. CONCLUSIONS: There were abnormalities in children's postural development that are probably related to muscle, skeletal and flexibility differences between the genders. These differences may influence each child's postural pattern during growth.CONTEXTUALIZAÇÃO: Alterações posturais são freqüentemente encontradas em crianças. Nessa fase, a postura sofre uma série de ajustes e adaptações às mudanças no próprio corpo. OBJETIVO: Identificar, de maneira qualitativa, quais as alterações posturais mais freqüentes em crianças entre sete e dez anos, comparando meninos e meninas, e avaliar a flexibilidade lombar desses sujeitos. MATERIAIS E MÉTODOS: Cento e

  7. Idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Noble Paul W

    2008-03-01

    Full Text Available Abstract Idiopathic pulmonary fibrosis (IPF is a non-neoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known provocation. IPF is a rare disease which affects approximately 5 million persons worldwide. The prevalence is estimated to be slightly greater in men (20.2/100,000 than in women (13.2/100,000. The mean age at presentation is 66 years. IPF initially manifests with symptoms of exercise-induced breathless and dry coughing. Auscultation of the lungs reveals early inspiratory crackles, predominantly located in the lower posterior lung zones upon physical exam. Clubbing is found in approximately 50% of IPF patients. Cor pulmonale develops in association with end-stage disease. In that case, classic signs of right heart failure may be present. Etiology remains incompletely understood. Some environmental factors may be associated with IPF (cigarette smoking, exposure to silica and livestock. IPF is recognized on high-resolution computed tomography by peripheral, subpleural lower lobe reticular opacities in association with subpleural honeycomb changes. IPF is associated with a pathological lesion known as usual interstitial pneumonia (UIP. The UIP pattern consists of normal lung alternating with patches of dense fibrosis, taking the form of collagen sheets. The diagnosis of IPF requires correlation of the clinical setting with radiographic images and a lung biopsy. In the absence of lung biopsy, the diagnosis of IPF can be made by defined clinical criteria that were published in guidelines endorsed by several professional societies. Differential diagnosis includes other idiopathic interstitial pneumonia, connective tissue diseases (systemic sclerosis, polymyositis, rheumatoid arthritis, forme fruste of autoimmune disorders, chronic hypersensitivity pneumonitis and other environmental (sometimes occupational exposures. IPF is typically progressive and leads to significant

  8. Monocyte Chemoattractant Protein-1 (MCP-1) as a Potential Therapeutic Target and a Noninvasive Biomarker of Liver Fibrosis Associated With Transient Myeloproliferative Disorder in Down Syndrome.

    Science.gov (United States)

    Kobayashi, Kenichiro; Yoshioka, Takako; Miyauchi, Jun; Nakazawa, Atsuko; Yamazaki, Shigeaki; Ono, Hiromi; Tatsuno, Michiko; Iijima, Kenta; Takahashi, Chiaki; Okada, Yoko; Teranishi, Kenji; Matsunaga, Takaaki; Matsushima, Chieko; Inagaki, Mayo; Suehiro, Minoru; Suehiro, Saori; Nishitani, Masahiko; Kubota, Hirohito; Iio, Jun; Nishida, Yoshinobu; Katayama, Tetsuo; Takada, Narito; Watanabe, Kentaro; Yamamoto, Tetsuro; Yasumizu, Ryoji; Matsuoka, Kentaro; Ohki, Kentaro; Kiyokawa, Nobutaka; Maihara, Toshiro; Usami, Ikuya

    2017-03-06

    Liver fibrosis is one of the common complications of transient myeloproliferative disorder (TMD) in Down syndrome (DS), but the exact molecular pathogenesis is largely unknown. We herein report a neonate of DS with liver fibrosis associated with TMD, in which we performed the serial profibrogenic cytokines analyses. We found the active monocyte chemoattractant protein-1 expression in the affected liver tissue and also found that both serum and urinary monocyte chemoattractant protein-1 concentrations are noninvasive biomarkers of liver fibrosis. We also showed a prospective of the future anticytokine therapy with herbal medicine for the liver fibrosis associated with TMD in DS.

  9. [Nephrogenic systemic fibrosis].

    Science.gov (United States)

    Artunc, F; Schanz, S; Metze, D; Heyne, N

    2008-01-01

    Nephrogenic systemic fibrosis (NSF) is a novel disease entity, increasingly diagnosed over the last years in patients with renal functional impairment and chronic kidney disease. Recently, gadolinium-containing MR contrast agents have been causally associated with the development NSF. Herein, we present the case of a dialysis-dependent young patient with systemic lupus erythematodes, who developed disabling cutaneous sclerosis of extremities, abdomen and mammae. Clinical and laboratory investigations revealed no signs of activity of the underlying disease. Histopathological examination of a skin biopsy was consistent with NSF showing profound thickening of tissue septae with mucine deposition and slight fibroblast proliferation without inflammatory reaction. Analysis of the patient's medical history revealed that she had undergone repeated contrast enhanced MR scans, including MR angiographies with high doses of gadopentetate. UV phototherapy was little effective, and not until kidney transplantation two years later with good allograft function, improvement of clinical symptoms was observed. Discussion of this case summarizes the current knowledge of clinical features and pathogeneses of NSF, including the role of gadolinium-containing contrast agents. Evolving clinical implications are summarized in the current Tübingen University Hospital guideline for the use of contrast-enhanced MR scans in patients with impaired renal function.

  10. What Are the Signs and Symptoms of Cystic Fibrosis?

    Science.gov (United States)

    ... Twitter. What Are the Signs and Symptoms of Cystic Fibrosis? The signs and symptoms of cystic fibrosis (CF) ... respiratory, digestive, or reproductive systems of the body. Cystic Fibrosis Figure A shows the organs that cystic fibrosis ...

  11. Antimicrobial susceptibility of Haemophilus influenzae in the respiratory tracts of patients with cystic fibrosis

    NARCIS (Netherlands)

    Moller, LVM; Regelink, AG; Grasselier, H; van Alphen, L

    1998-01-01

    We analyzed the antimicrobial susceptibilities of Haemophilus influenzae isolates from 157 sputum specimens prospectively collected from 39 cystic fibrosis (CF) patients during a 2-year study, These isolates were characterized by random amplified polymorphic DNA analysis and major outer membrane pro

  12. Nephrogenic systemic fibrosis

    Directory of Open Access Journals (Sweden)

    Bhushan Madke

    2011-01-01

    Full Text Available Nephrogenic systemic fibrosis (NSF is a relatively new fibrosing disorder which has caught the attention of various specialities in the past decade. NSF is an extremely disabling and often painful condition, affecting up to 13% of the individuals with chronic kidney disease. The administration of a gadolinium chelate contrast agent has been reported to induce the development of NSF, particularly in patients who have acute or chronic renal disease with a glomerular filtration rate (GFR lower than 30-mL/min/1.73 m 2 and in those with acute renal insufficiency. Mass spectroscopy studies have demonstrated particles of gadolinium in the lesional tissue. The exact pathogenesis of this curious sclerosing condition is unknown. The role of the aberrant targeting of ′circulating fibrocytes′ to the peripheral tissues and viscera has been hypothesized. NSF has distinct clinicopathological features in the setting of renal failure and needs to be looked upon as a new entity on the block. The condition is characterized by irregular indurated plaques, with amoeba-like projections and islands of sparing, chiefly on the trunk and extremities. Flexion contractures of fingers, knees, and elbow joints are known to occur in advanced cases of NSF. The course is frequently associated with painful episodes and loss of ambulation. Histopathology shows haphazard arrangement of thickened bundles of collagen, varying amount of mucin, and increased population of fibroblast-like cells in the dermis. Immunohistochemistry shows increased deposition of type-I procollagen and CD 34+ cells having fibroblastic activity. The condition is refractory to treatment with corticosteroids and immunosuppressive agents. Various modalities of therapy such as UVA1 phototherapy, imatinib mesylate, photodynamic therapy, plasmapheresis, extracorporeal photochemotherapy, and high-dose intravenous immunoglobulin have shown a moderate degree of improvement in skin thickness scores. A prudent

  13. ENDOMYOCARDIAL FIBROSIS IN CHINA

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Purpose.To introduce the epidemical, pathological, and clinical characteristics as well as the diagnostic and therapeutical experiences of endomyocardial fibrosis(EMF) in China. Data sources.A CMBdisc search was done of the Chinese-language literature published from January 1983 through June 1997 about EMF and/or restrictive cardiomyopathy. A manual search was then done for other contributions, including abstracts, between January 1965 and June 1997.Results. Eighty-seven Chinese cases of EMF were collected in this paper. There were 49 men and 38 women, with a mean age of 28±13 years(range, 8 to 68 years). The distribution of the cases is mainly in the south of China. Combined right and left ventricular disease occurs in 48 percent of cases, with pure right ventricular involvement occurring in 42 percent and pure left ventricular involvement in the remaining 10 percent of patients who are examined postmortem. The diagnosis of EMF was confirmed in 21 cases at autopsy, and in 66 cases by echocardiography, angiocardiography, and/or endomyocardial biopsy which showed the characteristic changes. Clinically, right-sided disease is the commonest variety. Endocardiectomy and tricuspid(n=7) or mitral(n=1) valves replacement have been performed in 8 patients. There were 2 operative deaths. Six patients had a satisfactory recovery postoperatively and living well in the follow-up duration. Conclusion.EMF has been diagnosed clinically and confirmed at necropsy in a number of cases in the south of China. The etiology, incidence and epidemiology are still unknown. The pathological and clinical features are similar to those in tropical areas, but right ventricular involvement is the commonest type in our country.

  14. Using Cystic Fibrosis Therapies for Non-Cystic Fibrosis Bronchiectasis.

    Science.gov (United States)

    ElMaraachli, Wael; Conrad, Douglas J; Wang, Angela C C

    2016-03-01

    Non-cystic fibrosis bronchiectasis (NCFB) is an increasingly prevalent disease that places a significant burden on patients and health systems globally. Although many of the therapies used to treat NCFB were originally developed as cystic fibrosis (CF) therapies, not all of them have been demonstrated to be efficacious in NCFB and some may even be harmful. This article explores the evidence for which therapeutic strategies used to treat CF have been translated into the care of NCFB. The conclusion is that therapies for adult NCFB cannot be simply extrapolated from CF clinical trials, and in some instances, doing so may actually result in harm.

  15. 颅内动脉瘤治疗十年回顾(附1372例治疗及随访)%Management of intracranial aneurysms: review of ten years experience

    Institute of Scientific and Technical Information of China (English)

    秦尚振; 陈刚; 张戈; 杜浩; 张新元; 姚国杰; 余光宏; 秦海林; 宋健; 马廉亭; 徐国政; 龚杰; 杨铭; 李俊; 余泽; 胡军民; 潘力

    2012-01-01

    Objective To summarize ten years experience in treating intracranial aneurysms (ICAN) in order to enhance the curative effect on them. Methods The clinical data of 1 372 patients with ICAN, of whom, 632 with 697 ICAN were treated by endovascular embolization (EVE) and 740 with 805 ICAN by microsurgery from January, 2000 to December, 2009, were analyzed retrospectively. Results The prognoses were assessed by GOS in all the patients. Of 564 patients with Hunt-Hess grades 0~Ⅲ treated by EVE, 536 (95.0%) had good prognoses, 22 (3.9%) were severely disabled and 6 (1.1%) died. Of 566 patients with Hunt-Hess grades 0~ Ⅲ treated by the microsurgery, 542 (95.8%) had good prognoses, 18 (3.2%) were severely disabled and 6 (1.1%) died. Of 68 patients with Hunt-Hess grades Ⅳ~Ⅴ treated by EVE, 32 (47.1%) had good prognoses, 18 (26.5%) were severely disabled and 18 (26.5%) died. Of 174 patients with Hunt-Hess grades Ⅳ ~ Ⅴ treated by the microsurgery, 84 (48.3%) had good prognoses, 55 (31.6%) were severely disabled, 7 (4.0%) vegetatively survived and 28 (16.1%) died. There was insignificant difference in the rates of good prognoses between both the EVE and microsurgical treatment groups (P>0.05). Of 26 patients with Hunt-Hess grade Ⅴ, 4 were severely disabled, 3 survived vegetatively and 19 died. DSA re-examination showed that of 167 patients treated by EVE, 138 had densely occluded aneurysms, 24 incompletely and 5 suffered from recurrence of aneurysms, and of 136 patients treated by the microsurgery, 129 received complete clipping of the aneurysms and 7 received incomplete. Conclusions The EVE and microsurgical clipping are the effective methods to treat ICAN. The methods to treat ICAN should be selected according to the aneurysmal region and size, and patient' s economic conditions. The anterior circulation aneurysms may be treated by both the EVE and microsurgical clipping. The EVE should be selected first for the posterior circulation aneurysms. The

  16. 10年间酒精所致精神障碍住院患者流行病学变迁%Epidemiological changes of hospitalized patients with mental disorders due to use of alcohol in ten years

    Institute of Scientific and Technical Information of China (English)

    任季冬; 罗明; 余佳

    2016-01-01

    目的:探讨酒精所致精神障碍患者的流行病学及临床特征。方法对2005年1月-2014年12月在攀枝花市第三人民医院诊断为酒精所致精神障碍/酒相关障碍(符合 ICD -10诊断标准)的住院病历档案进行回顾性调查分析。结果10年间共收治酒精所致精神障碍患者986例,住院构成比10年增长约1.5倍,男性961例(97.46%),女性25例(2.54%),男女比例约为38:1,平均发病年龄(46.16±11.92)岁;农民285例(28.9%),工人337例(34.2%),二者占酒精所致精神障碍住院患者的63.1%;病理分型中依赖综合症占33%,精神病性症状占48.1%;伴发躯体疾病中,肝损害142例(14.4%),心血管系统疾病121例(12.3%);平均初饮年龄(25.31±11.07)岁,平均嗜酒年限(21.08±10.91)年。结论酒精中毒导致的精神和躯体障碍逐渐增加,已是一个日趋严重的社会问题,应提倡早期干预,酒精所致精神障碍患者宜尽早戒酒。%Objective To explore the epidemiology and clinical features of patients with mental disorder due to use of alcohol. Methods The medical records of patients who were diagnosised with mental disorders due to use of alcohol/ alcohol related disorders (ICD - 10 diagnosis standard)were retrospective survey analysised in January 2005 to December 2014 in the No. 3 People’s Hospital of Panzhihua. Results During the ten years,a total of 986 patients with mental disorders due to use of alcohol were treated and hospitali-zation constituent ratio of the patients grew about 1. 5 times. Among these patients,there were 961 male cases(97. 46% )and 25 women cases(2. 53% ),the sex ratio was about 38:1. The average age was(46. 16 ± 11. 92). Distribution of professional,there were 285 cases(28. 9% )of farmers,337 cases(34. 2% )of workers,the two kinds of professional accounted for 63. 1% of hospitalized patients with mental disorders due to use of alcohol. The dependence

  17. 北京市东城区十年孕产妇死亡监测分析%Monitoring analysis on maternal mortality of Dongcheng District in Beijing in the past ten years

    Institute of Scientific and Technical Information of China (English)

    叶家林; 朱晓毅

    2009-01-01

    Objective: To observe the maternal mortality of Dongcheng District in Beijing from 1997 to 2006, explore the main death causes and changing trend and find an effective way to reduce the maternal mortality. Methods: The monitoring data of 27 maternal deaths from 1997 to 2006 were analysed retrospectively, the maternal mortality and death causes were compared between the first five years and the second five years. Results: From 1997 to 2006, there were totally 104 858 cases of live births and 27 eases of maternal deaths, the maternal mortality was 25.75/100 000. The maternal mortalities in the first five years and the second five years were 45. O2/100 000 and 13. 87/100 000; the main death causes were hypertensive disorder complicating pregnancy, liver disease during pregnancy, obstetric hemor-rhage, amniotic fluid embolism, heart disease, cerebral hemorrhage and ectopic pregnancy, the first death cause was hypertensive disorder complicating pregnancy and the second was liver disease during pregnancy. The percentage of direct obstetric causes of maternal deaths was 59. 26%. The percentage of maternal deaths without systemic perinatal health care was 55.56%, and ecdemic population accounted for 62.96%. Conclusion: The maternal mortality of Dongcheng District declined in the past ten years and the position of death causes changed also. Liver disease during pregnancy is the first death cause beyond hypertensive disorder complicating pregnancy. It affects the quality of perinatal health care that the eedemic population doesnt take systemic health care in perinatal period. How to effectively cover the ecdemic population by the maternal management system is the main problem faced by Dongcheng District. It is also the key point that following perina-tal work to improve the first-aid salve ability of medical treatment organization dealing with pregnancy incorporated diseases.%目的:调查北京市东城区辖区医院1997~2006年孕产妇死亡情况,探讨孕产妇死

  18. A review of lightning observation experiments during the last ten years in Guangdong%广东野外雷电综合观测试验十年进展

    Institute of Scientific and Technical Information of China (English)

    张义军; 潘汉波; 吕伟涛; 陈绍东; 郑栋; 张阳; 颜旭; 陈绿文; 董万胜; 但建茹

    2016-01-01

    triggered during the ten-year period, and the maximum and average peak current of return stroke is 42 kA and 16 kA,respectively.Types and difference characteris-tics of electric field change pulse involved in the preliminary breakdown process of natural lightning are analyzed.It is found that the length of upward connecting leader initiated from tall structures can be several hundred meters or even more than 1 km, and its speed can reach up to the magnitude of 106 m/s.Great diversity is found in the attachment of downward leader and up-ward connecting leader.Tests of lightning protection technology show that the voltage on the overhead lines induced by close-distance electromagnetic wave coupling from artificially triggered lightning could be up to the magnitude of kV.Multiple return strokes,continuing current and ground potential rise are the main factors that cause damages to surge protective device (SPD). Results of performance evaluation for the Lightning Location System of Guangdong-Hongkong-Macau show that the detection efficiency of flash and stroke are 96% and 89%,respectively;the arithmetic mean value of location error is 532 m;the esti-mated value of return stroke current intensity is about 63% of the true value.

  19. Pathological assessment of liver fibrosis regression

    Directory of Open Access Journals (Sweden)

    WANG Bingqiong

    2017-03-01

    Full Text Available Hepatic fibrosis is the common pathological outcome of chronic hepatic diseases. An accurate assessment of fibrosis degree provides an important reference for a definite diagnosis of diseases, treatment decision-making, treatment outcome monitoring, and prognostic evaluation. At present, many clinical studies have proven that regression of hepatic fibrosis and early-stage liver cirrhosis can be achieved by effective treatment, and a correct evaluation of fibrosis regression has become a hot topic in clinical research. Liver biopsy has long been regarded as the gold standard for the assessment of hepatic fibrosis, and thus it plays an important role in the evaluation of fibrosis regression. This article reviews the clinical application of current pathological staging systems in the evaluation of fibrosis regression from the perspectives of semi-quantitative scoring system, quantitative approach, and qualitative approach, in order to propose a better pathological evaluation system for the assessment of fibrosis regression.

  20. [Laparoscopic treatment of retroperitoneal fibrosis].

    Science.gov (United States)

    Joual, Abdenbi; Rabii, Redouane; El Mejjad, Amine; Fekak, Hamid; Debbagh, Adil; El Mrini, Mohamed

    2004-04-01

    The authors report a case of idiopathic retroperitoneal fibrosis (RPF) in a 38-year-old man presenting with obstructive acute renal failure. The initial management consisted of urinary diversion by bilateral double-J ureteric stenting. After restoration of normal renal function, CT urography demonstrated retroperitoneal fibrosis surrounding the two ureters. Surgical treatment was performed by laparoscopy using four trocars. The operation consisted of detachment of the ascending and descending colon followed by release of the ureters from the lumbar segment to the pelvic segment and finally intraperitonealization of the ureters. The operating time was six hours, the postoperative course was uneventful and the double-J stents were removed at the third week. Laparoscopic treatment of RPF is a treatment option providing all of the benefits of minimally invasive surgery. In the light of this case and a review of the literature, the authors describe the laparoscopic treatment of idiopathic retroperitoneal fibrosis.

  1. Nephrogenic systemic fibrosis: epidemiology update

    DEFF Research Database (Denmark)

    Marckmann, P.

    2008-01-01

    Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated that gadoli......Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated...

  2. Transient elastography for liver fibrosis diagnosis

    DEFF Research Database (Denmark)

    Andersen, Ellen Sloth; Christensen, Peer Brehm; Weis, Nina

    2009-01-01

    fibrosis. Most of the studies have been conducted on patients with chronic hepatitis but a few studies have also covered fibrosis and cirrhosis due to other etiologies, and they also demonstrate the high sensitivity and specificity. Transient elastography for assessment of fibrosis may turn out...

  3. Cystic Fibrosis (CF): Chloride Sweat Test

    Science.gov (United States)

    ... Old Feeding Your 1- to 2-Year-Old Cystic Fibrosis (CF) Chloride Sweat Test KidsHealth > For Parents > Cystic Fibrosis (CF) Chloride Sweat Test Print A A A ... It Is A chloride sweat test helps diagnose cystic fibrosis (CF) , an inherited disorder that makes kids sick ...

  4. What's it Like to Have Cystic Fibrosis?

    Science.gov (United States)

    ... Emergency Room? What Happens in the Operating Room? Cystic Fibrosis KidsHealth > For Kids > Cystic Fibrosis Print A A A What's in this article? ... with a condition she's known all her life — cystic fibrosis (say: SIS-tik fi-BRO-sus). Her parents ...

  5. Different types of incidence that revision cognitive processes have on narrative texts coherence: a research with ten-year-old children [Diferentes tipos de incidencia de los procesos cognitivos de revisión sobre la coherencia de textos narrativos: un estudio con niños de 10 años*

    Directory of Open Access Journals (Sweden)

    Diana de Castro

    2012-06-01

    Full Text Available The following research stands within the framework of cognitive develop- ment psychology. Its purpose is to identify how the revision process works in the re-writings done by ten-year-old children, and the incidence this has on establishing coherence in narrative texts. The qualitative and statistical analysis of three written productions and two conversations held with 30 ten-year-old children enables to identify the different types of incidence that revision has over coherence, as well as the paths followed by children to attain transformations at both structural and discursive levels. Analysis of children’s changes in their written productions allows noticing transfor- mations in coherence and it also helps identify the advances, retreats, oscil- lations, and permanence in the performances. Finally, mental functionings decisive for coherence are identified; the article ends up pointing out the importance of having educational proposals that focus on revision.

  6. Clinical results after ten years of the Lyon R96-02 trial: improving rectum conservation by increasing irradiation dose; Resultats cliniques a dix ans de l'essai Lyon R96-02: ameliorer la conservation du rectum en augmentant la dose d'irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Gerard, J.P. [Centre Antoine-Lacassagne, Nice (France); Ortholan, C. [Hopital Princesse-Grace, Monaco (Monaco); Chapet, O. [Centre hospitalier de Lyon-Sud, Pierre-Benite (France); Romestaing, P. [Hopital prive J.-Mermoz, Lyon (France)

    2011-10-15

    The author report and comments the results after ten years of a trial which aimed at testing the influence of a boost by pre-operative 50 kV contact radiotherapy on the sphincter or rectum conservation rate. Patient had been treated by external radiotherapy with or without this contact radiotherapy. Results are analysed in terms of complete or partial clinical response, global survival, local recurrence, and absence of colostomy. Short communication

  7. Cardiovascular magnetic resonance imaging to assess myocardial fibrosis in valvular heart disease.

    Science.gov (United States)

    Podlesnikar, Tomaz; Delgado, Victoria; Bax, Jeroen J

    2017-06-22

    The left ventricular (LV) remodeling process associated with significant valvular heart disease (VHD) is characterized by an increase of myocardial interstitial space with deposition of collagen and loss of myofibers. These changes occur before LV systolic function deteriorates or the patient develops symptoms. Cardiovascular magnetic resonance (CMR) permits assessment of reactive fibrosis, with the use of T1 mapping techniques, and replacement fibrosis, with the use of late gadolinium contrast enhancement. In addition, functional consequences of these structural changes can be evaluated with myocardial tagging and feature tracking CMR, which assess the active deformation (strain) of the LV myocardium. Several studies have demonstrated that CMR techniques may be more sensitive than the conventional measures (LV ejection fraction or LV dimensions) to detect these structural and functional changes in patients with severe left-sided VHD and have shown that myocardial fibrosis may not be reversible after valve surgery. More important, the presence of myocardial fibrosis has been associated with lesser improvement in clinical symptoms and recovery of LV systolic function. Whether assessment of myocardial fibrosis may better select the patients with severe left-sided VHD who may benefit from surgery in terms of LV function and clinical symptoms improvement needs to be demonstrated in prospective studies. The present review article summarizes the current status of CMR techniques to assess myocardial fibrosis and appraises the current evidence on the use of these techniques for risk stratification of patients with severe aortic stenosis or regurgitation and mitral regurgitation.

  8. Cough in idiopathic pulmonary fibrosis

    NARCIS (Netherlands)

    M.J.G. Van Manen (Mirjam J.G.); S.S. Birring (Surinder S.); C. Vancheri (Carlo); V. Cottin (Vincent); Renzoni, E.A. (Elisabetta A.); Russell, A.-M. (Anne-Marie); M.S. Wijsenbeek (Marlies)

    2016-01-01

    textabstractMany patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF,

  9. Hepatic fibrosis: Concept to treatment.

    Science.gov (United States)

    Trautwein, Christian; Friedman, Scott L; Schuppan, Detlef; Pinzani, Massimo

    2015-04-01

    Understanding the molecular mechanisms underlying liver fibrogenesis is fundamentally relevant to developing new treatments that are independent of the underlying etiology. The increasing success of antiviral treatments in blocking or reversing the fibrogenic progression of chronic liver disease has unearthed vital information about the natural history of fibrosis regression, and has established important principles and targets for antifibrotic drugs. Although antifibrotic activity has been demonstrated for many compounds in vitro and in animal models, none has been thoroughly validated in the clinic or commercialized as a therapy for fibrosis. In addition, it is likely that combination therapies that affect two or more key pathogenic targets and/or pathways will be needed. To accelerate the preclinical development of these combination therapies, reliable single target validation is necessary, followed by the rational selection and systematic testing of combination approaches. Improved noninvasive tools for the assessment of fibrosis content, fibrogenesis and fibrolysis must accompany in vivo validation in experimental fibrosis models, and especially in clinical trials. The rapidly changing landscape of clinical trial design for liver disease is recognized by regulatory agencies in the United States (FDA) and Western Europe (EMA), who are working together with the broad range of stakeholders to standardize approaches to testing antifibrotic drugs in cohorts of patients with chronic liver diseases.

  10. Lung transplantation for cystic fibrosis

    NARCIS (Netherlands)

    Adler, Frederick R; Aurora, Paul; Barker, David H; Barr, Mark L; Blackwell, Laura S; Bosma, Otto H; Brown, Samuel; Cox, D R; Jensen, Judy L; Kurland, Geoffrey; Nossent, George D; Quittner, Alexandra L; Robinson, Walter M; Romero, Sandy L; Spencer, Helen; Sweet, Stuart C; van der Bij, Wim; Vermeulen, J; Verschuuren, Erik A M; Vrijlandt, Elianne J L E; Walsh, William; Woo, Marlyn S; Liou, Theodore G

    2009-01-01

    Lung transplantation is a complex, high-risk, potentially life-saving therapy for the end-stage lung disease of cystic fibrosis (CF). The decision to pursue transplantation involves comparing the likelihood of survival with and without transplantation as well as assessing the effect of wait-listing

  11. Update on nephrogenic systemic fibrosis

    DEFF Research Database (Denmark)

    Marckmann, P.; Logager, V.B.; Thomsen, Henrik S.

    2008-01-01

    Gadolinium-based contrast agents were for many years considered safe, but this is no longer the case. The least stable agents may trigger the development of nephrogenic systemic fibrosis (NSF), a generalized fibrotic disorder, in renal failure patients. The use of gadodiamide and gadopentetate di...

  12. Lactate in cystic fibrosis sputum

    DEFF Research Database (Denmark)

    Bensel, Tobias; Stotz, Martin; Borneff-Lipp, Marianne

    2011-01-01

    Antibiotic therapy is thought to improve lung function in patients with cystic fibrosis (CF) by decreasing neutrophil-derived inflammation. We investigated the origin and clinical significance of lactate in the chronically inflamed CF lung. Methods Lactate was measured in sputa of 18 exacerbated ...

  13. Cough in idiopathic pulmonary fibrosis

    NARCIS (Netherlands)

    M.J.G. Van Manen (Mirjam J.G.); S.S. Birring (Surinder S.); C. Vancheri (Carlo); V. Cottin (Vincent); Renzoni, E.A. (Elisabetta A.); Russell, A.-M. (Anne-Marie); M.S. Wijsenbeek (Marlies)

    2016-01-01

    textabstractMany patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF,

  14. Pseudomembranous colitis in cystic fibrosis.

    Science.gov (United States)

    Nagakumar, Prasad

    2013-05-01

    Cystic fibrosis (CF) patients may require frequent courses of antibiotics and repeated hospital admissions. Although children with CF have high carriage rate for C.difficile, they rarely develop colitis. Pseudomembranous colitis is more common in adult post lung transplant CF patients. Although rare, paseudomembranous colitis should be considered in CF patients presenting with abdominal symptoms even in the absence of diarrhoea.

  15. [Therapeutic update in cystic fibrosis].

    Science.gov (United States)

    Durupt, S; Nove Josserand, R; Durieu, I

    2014-06-01

    We present the recent therapeutic advances in the cystic fibrosis care. It concerns improvements in symptomatic treatment with the development of dry powder inhaled antibiotics that improved quality of life, and innovative treatments namely the modulators of the cystic fibrosis transmembrane protein conductance regulator (CFTR), molecules which act specifically at the level of the defective mechanisms implied in the disease. The life expectancy of cystic fibrosis patients born after 2000, is estimated now to be about 50 years. This improvement of survival was obtained with the organization of the care within the specialized centers for cystic fibrosis (Centre de ressource et de compétences de la mucoviscidose) and remains still based on heavy symptomatic treatments. Dry powder inhaled antibiotics constitute a significant time saving for patients to whom all the care can achieve two hours daily. Since 2012, the modulators of CFTR, molecules allowing a pharmacological approach targeted according to the type of the mutations, allows a more specific approach of the disease. Ivacaftor (Kalydeco(®)) which potentialises the function of the CFTR protein expressed on the cellular surface is now available for patients with the G551D mutation. Lumacaftor is going to be tested in association with ivacaftor in patients with the F508del mutation, that is present in at least 75% of the patients. The ataluren which allows the production of a functional protein CFTR in patients with a no sense mutation is the third representing of this new therapeutic class. We presently have numerous symptomatic treatments for the cystic fibrosis care. The development of CFTR modulators, today available to a restricted number of patients treated with ivacaftor represents a very promising therapeutic avenue. It will represent probably the first step to a personalized treatment according to CFTR genotype. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by

  16. 国内语际语用学近十年研究述评%The Review of Ten-year Inter-language Pragmatics Research Methods and Its Outlook in China

    Institute of Scientific and Technical Information of China (English)

    邓娟

    2016-01-01

    The present research reviews the research fruits of inter‐language pragmatics during 2004 to 2014 in the national key journals and investigates the theory and empirical research methods .On one hand , theory research methods involves history ,theory and methodology ,prospects of inter‐language pragmat‐ics ,pragmatic competence and its influencing factors ,pragmatic failure ,pragmatics and teaching ,prag‐matics and translation ,cognitive research of inter‐language pragmatics .On the other hand ,empirical re‐search deals with the speech of target language ,use and acquisition of discourse markers ,conversation a‐nalysis and deixis acquisition in second language acquisition ,pragmatic failure and transfer ,inter‐language competence ,pragmatics and foreign language teaching .The research aims to predict the future inter‐lan‐guage research methods .%回顾了国内外语核心期刊2004-2014年发表的语际语用学研究成果,调研了语际语用学理论研究和实证研究的方法,理论研究涉及到语际语用学发展的历史研究、理论基础和方法及其发展前景,语用能力、影响语用能力的各种因素、语用失误、语用与教学、语用与翻译、语际语用学的认知研究;实证研究涉及到目标语言语行为、话语标记语的使用与习得法、二语习得中的会话分析、二语中指示语的习得、语用失误和语用迁移、语际语用能力、语用学与外语教学这七各方面。基于这十年的研究成果展望未来的语际语用学研究方法。

  17. [Mechanism of and Therapy for Kidney Fibrosis].

    Science.gov (United States)

    Kuma, Akihiro; Tamura, Masahito; Otsuji, Yutaka

    2016-03-01

    Fibrosis occurs in systemic tissues other than the brain and finally induces dysfunction of the fibrotic organ. Kidney fibrosis is related to scarring after acute kidney injury and the progression of chronic kidney disease. Kidney function decreases with the progression of kidney fibrosis. As fibrotic tissue cannot return to its original status, advanced kidney fibrosis requires the administration of dialysis or kidney transplantation. Thus, elucidation the mechanism of kidney fibrosis is an important research theme. The proliferation and activation of (myo) fibroblasts and the excessive production of an extracellular matrix are common mechanisms in fibrosis in many organs, but it seems that kidney fibrosis has specific pathways. Tubular epithelial, mesangial cells, and erythropoietin producing cells, which exist only in the kidney, participate in forming kidney fibrosis. This review highlights an understanding of the cells and their underlying mechanisms, which are specific to kidney fibrosis process: transforming growth factor-β (TGF-β), epithelial-mesenchymal transition, wingless/int-1 (WNT) signaling, renal anemia, and uremia. Finally, we describe potential therapies that focus on the mechanisms of kidney fibrosis: anti-TGF-β antibody and mammalian target of rapamycin (mTOR).

  18. Algoritmo para el tratamiento del neumotórax traumático: experiencia de 10 años Algorithm for treatment of traumatic pneumothorax: ten-years experience

    Directory of Open Access Journals (Sweden)

    Gimel Sosa Martín

    2010-12-01

    diseases. The objective of present paper was to analyze the behavior of he spontaneous and traumatic pneumothorax and also to assess its treatment. METHODS. A multi-center study was conducted using analytical, descriptive, retrospective and prospective, cross-sectional elements in 154 patients with clinical, radiological diagnosis of the pneumothorax seen between October, 1998 and December, 2008, following the work algorithm designed for this aim. Study sample included 154 patients. RESULTS. In present study there was predominance of male sex, smoking and the type of traumatic pneumothorax. The minimal pleurotomy was effective in the 94,8% of patients. The traumatic pneumothorax were 126 (81,2%. From these, 120 (77,9% were caused by firearms wounds and contusions and six were of iatrogenic type (3,8%. The more frequent complication after pleurotomy was the pleural tube obstruction. CONCLUSIONS. The medical treatment, indifferent minimal pleurotomy, the high minimal pleurotomy and the chemical pleurodesis had a effectiveness between the 90 and the 100%. There was predominance of several types of traumatic pneumothorax In this series, thoracotomy indications were due to a persistent, traumatic, relapsing pneumothorax.

  19. Associations between N-terminal procollagen type III, fibrosis and echocardiographic indices in dogs that died due to myxomatous mitral valve disease.

    Science.gov (United States)

    Hezzell, Melanie J; Falk, Torkel; Olsen, Lisbeth Høier; Boswood, Adrian; Elliott, Jonathan

    2014-12-01

    To evaluate associations between N-terminal procollagen type III (PIIINP), a serum biomarker of collagen biosynthesis, and myocardial fibrosis in dogs with naturally-occurring myxomatous mitral valve disease (MMVD). Twenty-two dogs with echocardiographically-confirmed MMVD were prospectively recruited from a hospital population. All died as a result of MMVD and their hearts were available for post mortem examination. Echocardiographic measurements and serum PIIINP concentrations were obtained from all dogs prior to death or euthanasia. Serum PIIINP concentrations (μg/mL) were measured using a validated commercially available radioimmunoassay. Myocardial tissue samples were collected post mortem and myocardial fibrosis was scored. The average fibrosis score for all cardiac sites in the heart was designated the global fibrosis score (GFS). The average fibrosis score for all papillary muscle sites was designated the papillary fibrosis score (PFS). Univariate and multivariate linear regression analyses were used separately to evaluate associations between GFS and PFS, respectively, and PIIINP and echocardiographic variables. Left ventricular end-diastolic diameter normalized for body weight (LVEDDN) and PIIINP were weakly independently positively associated with both GFS and PFS. LVEDDN and PIIINP were weakly negatively correlated. Both LVEDDN and serum PIIINP increase with increasing fibrosis score, although these relationships were not strong enough to be clinically useful. Although LVEDDN and PIIINP were positively correlated with fibrosis, PIIINP decreased with increasing LVEDDN, suggesting a complex interplay between fibrosis and remodeling in MMVD. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. Epidemiology of idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Ley B

    2013-11-01

    Full Text Available Brett Ley, Harold R Collard Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, California, USA Abstract: Idiopathic pulmonary fibrosis is a chronic fibrotic lung disease of unknown cause that occurs in adults and has a poor prognosis. Its epidemiology has been difficult to study because of its rarity and evolution in diagnostic and coding practices. Though uncommon, it is likely underappreciated both in terms of its occurrence (ie, incidence, prevalence and public health impact (ie, health care costs and resource utilization. Incidence and mortality appear to be on the rise, and prevalence is expected to increase with the aging population. Potential risk factors include occupational and environmental exposures, tobacco smoking, gastroesophageal reflux, and genetic factors. An accurate understanding of its epidemiology is important, especially as novel therapies are emerging. Keywords: idiopathic pulmonary fibrosis, epidemiology, incidence, prevalence, mortality, risk factors

  1. [Historical compilation of cystic fibrosis].

    Science.gov (United States)

    Navarro, Salvador

    2016-01-01

    Cystic fibrosis is the most common life-shortening recessively inherited disorder in the Caucasian population. The genetic mutation that most frequently provokes cystic fibrosis (ΔF508) appeared at least 53,000years ago. For many centuries, the disease was thought to be related to witchcraft and the "evil eye" and it was only in 1938 that Dorothy H. Andersen characterized this disorder and suspected its genetic origin. The present article reviews the pathological discoveries and diagnostic and therapeutic advances made in the last 75 years. The review ends with some considerations for the future. Copyright © 2015 Elsevier España, S.L.U. and AEEH y AEG. All rights reserved.

  2. Fibrosis endomiocárdica

    Directory of Open Access Journals (Sweden)

    María Juliana Rodríguez-González

    2017-07-01

    Una de las formas más comunes de miocardiopatía restrictiva es la fibrosis endomiocárdica la cual es endémica en algunas zonas tropicales especialmente en África (países de bajos ingresos, pero en nuestro medio hay pocos reportes de aparición. Su etiología es desconocida, aunque existen diversos mecanismos que han sido involucrados en su fisiopatología. Su diagnóstico se basa en estudios imagenológicos (ecocardiograma transtorácico y resonancia magnética nuclear cardíaca. El pronóstico es muy pobre, y usualmente se diagnostica en etapas muy avanzadas de la enfermedad. Se describe el caso de una paciente femenina, adulta media, que debutó con cardiopatía restrictiva, cuyo diagnóstico final fue fibrosis endomiocárdica.

  3. Pathogenesis of oral submucous fibrosis

    Directory of Open Access Journals (Sweden)

    Saba Khan

    2012-01-01

    Full Text Available Data from recent epidemiological studies provide overwhelming evidence that areca nut is the main etiological factor for oral submucous fibrosis (OSF. It is logical to hypothesize that the increased collagen synthesis or reduced collagen degradation is the possible mechanism in the development of the disease. There are numerous biological pathways involved in the above processes and it is likely that the normal regulatory mechanisms are either down regulated or up regulated at different stages of the disease. The copper content of areca nut is high and the possible role of copper as a mediator of fibrosis is supported by the demonstration of the up regulation of lysyl oxidase in OSMF biopsies. The aim of this article is to emphasize that the incorporation of copper into the areca nut is through the Bordeaux mixture, which is sprayed as a fungicide on areca plantations in regions with scheduled monsoons and of which copper sulfate is an important constituent.

  4. Liver shear-wave velocity and serum fibrosis markers to diagnose hepatic fibrosis in patients with chronic viral hepatitis B

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Jian Xue; Ji, Yong Hao; Zhao Junzhi; Zhang, Yao Ren; Dun, Guo Liang; Ning, Bo [Dept. of Ultrasonography, Baoji Central Hospital, Baoji (China); Ai, Hong [Dept. of Ultrasonography, The First Affiliated Hospital of Medical College, Xi' an Jiaotong University, Xi' an (China)

    2016-06-15

    To compare several noninvasive indices of fibrosis in chronic viral hepatitis B, including liver shear-wave velocity (SWV), hyaluronic acid (HA), collagen type IV (CIV), procollagen type III (PCIII), and laminin (LN). Acoustic radiation force impulse (ARFI) was performed in 157 patients with chronic viral hepatitis B and in 30 healthy volunteers to measure hepatic SWV (m/s) in a prospective study. Serum markers were acquired on the morning of the same day of the ARFI evaluation. Receiver operating characteristic (ROC) analysis was performed to evaluate and compare the accuracies of SWV and serum markers using METAVIR scoring from liver biopsy as a reference standard. The most accurate test for diagnosing fibrosis F ≥ 1 was SWV with the area under the ROC curve (AUC) of 0.913, followed by LN (0.744), HA (0.701), CIV (0.690), and PCIII (0.524). The best test for diagnosing F ≥ 2 was SWV (AUC of 0.851), followed by CIV (0.671), HA (0.668), LN (0.562), and PCIII (0.550). The best test for diagnosing F ≥ 3 was SWV (0.854), followed by CIV (0.693), HA (0.675), PCIII (0.591), and LN (0.548). The best test for diagnosing F = 4 was SWV (0.965), followed by CIV (0.804), PCIII (0.752), HA (0.744), and LN (0.662). SWV combined with HA and CIV did not improve diagnostic accuracy (AUC = 0.931 for F ≥ 1, 0.863 for F ≥ 2, 0.855 for F ≥ 3, 0.960 for F = 4). The performance of SWV in diagnosing liver fibrosis is superior to that of serum markers. However, the combination of SWV, HA, and CIV does not increase the accuracy of diagnosing liver fibrosis and cirrhosis.

  5. Idiopathic pulmonary fibrosis: treatment update.

    LENUS (Irish Health Repository)

    O'Connell, Oisin J

    2011-11-01

    Idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic interstitial pneumonias. Despite multiple recent clinical trials, there is no strong evidence supporting a survival advantage for any agent in the management of patients with IPF. The limited effectiveness of current treatment regimes has led to a search for novel therapies including antifibrotic strategies. This article reviews the evidence supporting the treatments currently used in the management of IPF.

  6. Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha

    Institute of Scientific and Technical Information of China (English)

    Dariusz Marek Lebensztejn; Maria El(z)bieta Sobaniec-Lotowska; Maciej Kaczmarski; Michael Voelker; Detlef Schuppan

    2006-01-01

    AIM: To evaluate prospectively 4 selected serum fibrosis markers (tenascin, hyaluronan, collagen Ⅵ, TIMP-1)before, during and 12 mo after IFN treatment of children with chronic hepatitis B.METHODS: Forty-seven consecutive patients wit-h chronic hepatitis B (range 4-16 years, mean 8 years) underwent IFN treatment (3 MU tiw for 20 wk). Fibrosis stage and inflammation grade were assessed in a blinded fashion before and 12 mo after end of treatment. Serum fibrosis markers were determined using automated assays.RESULTS: IFN treatment improved histological inflammation but did not change fibrosis in the whole group or in subgroups. Only hyaluronan correlated significantly with histological fibrosis(r = 0.3383, P = 0.021).Basal fibrosis markers did not differ between responders (42.5%) and nonresponders(57.5% ). During IFN treatment only serum tenascin decreased significantly in the whole group and in nonresponders. When pretreatment values were compared to values 12 mo after therapy, TIMP-1 increased in all patients and in nonresponders, and hyaluronan decreased in all patients and in responders.CONCLUSION: Tenascin reflects hepatic fibrogenesis and inflammation which decreases during IFN treatment of children with chronic hepatitis B. TIMP-1 correlates with nonresponse and hyaluronan with histological fibrosis.

  7. Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha.

    Science.gov (United States)

    Lebensztejn, Dariusz-Marek; Sobaniec-Lotowska, Maria-Elzbieta; Kaczmarski, Maciej; Voelker, Michael; Schuppan, Detlef

    2006-06-07

    To evaluate prospectively 4 selected serum fibrosis markers (tenascin, hyaluronan, collagen VI, TIMP-1) before, during and 12 mo after IFN treatment of children with chronic hepatitis B. Forty-seven consecutive patients with chronic hepatitis B (range 4-16 years, mean 8 years) underwent IFN treatment (3 MU tiw for 20 wk). Fibrosis stage and inflammation grade were assessed in a blinded fashion before and 12 mo after end of treatment. Serum fibrosis markers were determined using automated assays. IFN treatment improved histological inflammation but did not change fibrosis in the whole group or in subgroups. Only hyaluronan correlated significantly with histological fibrosis(r = 0.3383, P = 0.021). Basal fibrosis markers did not differ between responders (42.5%) and nonresponders(57.5%). During IFN treatment only serum tenascin decreased significantly in the whole group and in nonresponders. When pretreatment values were compared to values 12 mo after therapy, TIMP-1 increased in all patients and in nonresponders, and hyaluronan decreased in all patients and in responders. Tenascin reflects hepatic fibrogenesis and inflammation which decreases during IFN treatment of children with chronic hepatitis B. TIMP-1 correlates with nonresponse and hyaluronan with histological fibrosis.

  8. Oral submucous fibrosis: an update

    Directory of Open Access Journals (Sweden)

    Wollina U

    2015-04-01

    Full Text Available Uwe Wollina,1 Shyam B Verma,2 Fareedi Mukram Ali,3 Kishor Patil4 1Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; 2Nirvana Skin Clinic, Vadodara, Gujarat, India; 3Departments of Oral and Maxillofacial Surgery, SMBT Dental College, Sangamner, Maharashtra, India; 4Departments of Oral Pathology and Microbiology, SMBT Dental College, Sangamner, Maharashtra, India Abstract: Oral submucous fibrosis (OSF is a premalignant condition caused by betel chewing. It is very common in Southeast Asia but has started to spread to Europe and North America. OSF can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. OSF is a diagnosis based on clinical symptoms and confirmation by histopathology. Hypovascularity leading to blanching of the oral mucosa, staining of teeth and gingiva, and trismus are major symptoms. Major constituents of betel quid are arecoline from betel nuts and copper, which are responsible for fibroblast dysfunction and fibrosis. A variety of extracellular and intracellular signaling pathways might be involved. Treatment of OSF is difficult, as not many large, randomized controlled trials have been conducted. The principal actions of drug therapy include antifibrotic, anti-inflammatory, and antioxygen radical mechanisms. Potential new drugs are on the horizon. Surgery may be necessary in advanced cases of trismus. Prevention is most important, as no healing can be achieved with available treatments. Keywords: betel nut, betel quid, oral disease, squamous cell carcinoma, tobacco, fibrosis

  9. Recommendations for quality improvement in genetic testing for cystic fibrosis European Concerted Action on Cystic Fibrosis

    NARCIS (Netherlands)

    Dequeker, E; Cuppens, H; Dodge, J; Estivill, [No Value; Goossens, M; Pignatti, PF; Scheffer, H; Schwartz, M; Schwarz, M; Tummler, B; Cassiman, JJ

    These recommendations for quality improvement of cystic fibrosis genetic diagnostic testing provide general guidelines for the molecular genetic testing of cystic fibrosis in patients/individuals. General strategies for testing as well as guidelines for laboratory procedures, internal and external

  10. Cystic fibrosis from the gastroenterologist's perspective.

    Science.gov (United States)

    Ooi, Chee Y; Durie, Peter R

    2016-03-01

    Cystic fibrosis is a life-limiting, recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Increased survival outcomes and the multisystem nature of the disease, including the involvement of hepatobiliary and gastrointestinal tracts, now require the need for more extensive knowledge and expertise in cystic fibrosis among gastroenterologists. Manifestations are either a direct consequence of the primary defect in cystic fibrosis or a secondary complication of the disease or therapy. Adult patients with cystic fibrosis also have an increased risk of malignancy in the gastrointestinal and pancreatico-biliary tracts compared with the general population. Novel treatments that target the basic defects in the CFTR protein have emerged, but to date not much is known about their effects on the gastrointestinal and hepatobiliary systems. The introduction of such therapies has provided new opportunities for the application of intestinal endpoints in clinical trials and the understanding of underlying disease mechanisms that affect the gut in cystic fibrosis.

  11. HIV Infection Accelerates Hepatitis C-Related Liver Fibrosis

    Science.gov (United States)

    ... HIV Infection Accelerates Hepatitis C–Related Liver Fibrosis HIV Infection Accelerates Hepatitis C–Related Liver Fibrosis Email ... the progression of other chronic diseases as well. HIV and Fibrosis Dr. Kirk and his team tapped ...

  12. Clinical effects of sinus surgery and adjuvant therapy in cystic fibrosis patients - can chronic lung infections be postponed?

    DEFF Research Database (Denmark)

    Aanaes, K; Johansen, H K; Skov, M

    2013-01-01

    The paranasal sinuses can be a bacterial reservoir for pulmonary infections in patients with cystic fibrosis (CF) METHODOLOGY: In this prospective, non-randomised, uncontrolled, intervention cohort study, the clinical effect of sinus surgery followed by two weeks` intravenous antibiotics, 6 months...

  13. Effects of Positive End-Expiratory Pressure on Oscillated Volume during High-Frequency Chest Compression in Children with Cystic Fibrosis

    OpenAIRE

    Dosman, Cara F; Peter C Zuberbuhler; Tabk, Joan I; Jones, Richard L

    2003-01-01

    OBJECTIVE: To investigate the effects of positive end-expiratory pressure (PEEP) on end-expiratory lung volume (EELV) and mean oscillated volume (Vosc) during high frequency chest compression (HFCC).DESIGN: A clinic-based prospective intervention study.SETTING: Pulmonary function laboratory, University of Alberta, Edmonton, Alberta.POPULATION: Nine children with cystic fibrosis with little or no obstructive airway disease who were selected from the outpatient Cystic Fibrosis and Pediatric Pul...

  14. Oral Pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study

    Directory of Open Access Journals (Sweden)

    Mitchell James B

    2007-05-01

    Full Text Available Abstract Background Fibrosis is a common side effect after treatment with ionizing radiation. Several methods to ameliorate debilitating fibrosis have been employed but without consistent results. The goal of this pilot study is to determine if Pirfenidone, a novel regulator of cytokine gene expression, has the potential to ameliorate established radiation-induced fibrosis. Methods Open label, prospective pilot study of 800 mg three times/day, orally administered Pirfenidone was administered to enrolled patients who were had completed radiation therapy and who had established radiation-induced fibrosis. Range of motion (ROM was assessed using standard measures, and subjective measures of pain, fatigue, disability and global health were measured every three months. Results Seven patients were enrolled of whom 3 had ROM assessments of 1 site and 2 had ROM assessments of 2 sites. Of these assessments, 6 revealed increased ROM during drug intervention while 1 revealed a decreased ROM. There was an overall improvement in the mental composite score of the SF36 while physical composite score was decreased and the vitality score was unchanged. Two patients were removed from the study because of syncopal episodes. Conclusion Several patients experienced improved function of at least 25% and reported subjective improvement. Pirfenidone may benefit patients with radiation-induced fibrosis and is worthy of a larger well controlled trial.

  15. Viscoelasticity-based magnetic resonance elastography for the assessment of liver fibrosis in hepatitis C patients after liver transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Kamphues, C.; Bova, R.; Yahyazadeh, A.; Bahra, M.; Neuhaus, P. [Charite, Campus Virchow Klinikum, Berlin (Germany). Klinik fuer Allgemein-, Viszeral- und Transplantationschirurgie; Klatt, D.; Braun, J.; Sack, I.; Asbach, P. [Charite - Universitaetsmedizin, Berlin (Germany). Klinik fuer Radiologie; Klauschen, F. [Charite - Universitaetsmedizin, Berlin (Germany). Inst. fuer Pathologie

    2012-11-15

    Purpose: Despite advantages in antiviral therapy of hepatitis C (HCV) in recent years, progressing liver fibrosis remains a major problem for patients suffering from hepatitis C after liver transplantation. Therefore, effective non-invasive methods for the assessment of liver fibrosis are needed in order to guide treatment decisions and predict prognosis in these patients. The aim of this study was to prospectively assess the diagnostic accuracy of viscoelasticity-based magnetic resonance (MR) elastography for the assessment of liver fibrosis in HCV patients after liver transplantation. Materials and Methods: After IRB approval, a total of 25 patients, who had received a liver graft due to chronic hepatitis C underwent both liver biopsy and MR elastography. Two viscoelastic constants, the shear elasticity {mu} and the powerlaw exponent {alpha} were calculated by fitting the frequency function of the complex shear modulus with the viscoelastic springpot-model. Results: A strong positive correlation between shear elasticity {mu} and the stage of fibrosis could be found (R = 0.486, p = 0.0136). The area under the receiver operating curve (AUROC) of MR elastography based on {mu} for diagnosis of severe fibrosis (F {>=} 3) was 0.87 and 0.65 for diagnosis of significant fibrosis (F {>=} 2). The powerlaw exponent {alpha} did not correlate with the stage of fibrosis. Conclusion: MR elastography represents a promising non-invasive procedure for the assessment of higher grades of fibrosis in HCV patients after liver transplantation. The poor correlation for lower grades of fibrosis suggests unknown mechanical interactions in the transplanted liver. (orig.)

  16. Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest

    Directory of Open Access Journals (Sweden)

    Bismut Françoise

    2010-04-01

    Full Text Available Abstract Background FibroTest and elastography have been validated as biomarkers of liver fibrosis in the most frequent chronic liver diseases and in the fibrosis screening of patients with diabetes. One challenge was to use them for estimating the prevalence of fibrosis, identifying independent risk factors and to propose screening strategies in the general population. Methods We prospectively studied 7,463 consecutive subjects aged 40 years or older. Subjects with presumed advanced fibrosis (FibroTest greater than 0.48 were re-investigated in a tertiary center. Results The sample characteristics were similar to those of the French population. FibroTest was interpretable in 99.6%. The prevalence of presumed fibrosis was 2.8%, (209/7,463, including cirrhosis in 0.3% (25/7,463; 105/209 (50% subjects with presumed fibrosis accepted re-investigation. Fibrosis was confirmed in 50, still suspected in 27, indeterminate in 25 and not confirmed with false positive FibroTest or false negative elastography in 3 subjects. False negative rate of FibroTest estimated using elastography was 0.4% (3/766. The attributable causes for confirmed fibrosis were both alcoholic and nonalcoholic fatty liver disease (NAFLD in 66%, NAFLD in 13%, alcohol in 9%, HCV in 6%, and other in 6%. Factors independently associated (all P Conclusions Biomarkers have permitted to estimate prevalence of advanced fibrosis around 2.8% in a general population aged 40 years or older, and several risk factors which may be used for the validation of selective or non-selective screening strategies.

  17. The Sociology and Entrenchment. A Cystic Fibrosis Test for Everyone?

    DEFF Research Database (Denmark)

    Koch, Lene; Stemerding, Dirk

    1994-01-01

    Socialmedicine, genetic screening, cystic fibrosis, ethics, political regulation, sociology of technology......Socialmedicine, genetic screening, cystic fibrosis, ethics, political regulation, sociology of technology...

  18. Recent concepts on cystic fibrosis Fibrosis quística

    Directory of Open Access Journals (Sweden)

    William Parra

    1991-01-01

    Full Text Available

    Up to date concepts on Cystic Fibrosis are summarized in this article; the following are included: Incidence, pathogenesis, prenatal and postnatal diagnosis, treatment, genetics and future perspectives. Criteria are given for suspecting the disease and emphasis is made on the fact that its frequency in Colombia may be higher than usually thought.

    En este artículo se actualizan algunos conceptos sobre la Fibrosis Quística y su manejo; se incluyen los siguientes: incidencia, patogénesis, bases para el diagnóstico incluyendo el prenatal, tratamiento, aspectos gen éticos y perspectivas futuras. Se hace énfasis en la necesidad de pensar más a menudo en la enfermedad pues su frecuencia en Colombia puede ser mayor de lo que usualmente se acepta.

  19. Endocrine Disorders in Cystic Fibrosis.

    Science.gov (United States)

    Blackman, Scott M; Tangpricha, Vin

    2016-08-01

    Cystic fibrosis is frequently complicated by endocrine disorders. Diabetes can be expected to affect most with CF and pancreatic insufficiency and varies widely in age of onset, but early identification and treatment improve morbidity and mortality. Short stature can be exacerbated by relative delay of puberty and by use of inhaled corticosteroids. Bone disease in CF causes fragility fractures and should be assessed by monitoring bone mineral density and optimizing vitamin D status. Detecting and managing endocrine complications in CF can reduce morbidity and mortality in CF. These complications can be expected to become more common as the CF population ages. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. PROSPECTING EXPLORATION

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>20082879 Chen Yaoyu(No.3 Geology and Mineral Exploration Team,Gansu Provincial Bureau of Geology and Mineral Exploration and Development,Lanzhou 730050,China); Gong Quansheng Discussion on the Division of Deposit Scale and the Index of Ore Prospecting(Gansu Geology,ISSN 1004—4116,CN62—1191/P,16(3),2007,p.6—11,4 tables,6 refs.) Key words:prospecting and exploration of mineral

  1. Outcome in cystic fibrosis liver disease.

    LENUS (Irish Health Repository)

    Rowland, Marion

    2011-01-01

    Evidence suggests that cystic fibrosis liver disease (CFLD) does not affect mortality or morbidity in patients with cystic fibrosis (CF). The importance of gender and age in outcome in CF makes selection of an appropriate comparison group central to the interpretation of any differences in mortality and morbidity in patients with CFLD.

  2. European Cystic Fibrosis Society Standards of Care

    DEFF Research Database (Denmark)

    Stern, Martin; Bertrand, Dominique Pougheon; Bignamini, Elisabetta;

    2014-01-01

    Since the earliest days of cystic fibrosis (CF) treatment, patient data have been recorded and reviewed in order to identify the factors that lead to more favourable outcomes. Large data repositories, such as the US Cystic Fibrosis Registry, which was established in the 1960s, enabled successful...

  3. HOME CARE IN CYSTIC-FIBROSIS PATIENTS

    NARCIS (Netherlands)

    VANAALDEREN, WMC; MANNES, GPM; BOSMA, ES; ROORDA, RJ; HEYMANS, HSA

    1995-01-01

    Intravenous antibiotics and enteral tube feeding at home for the treatment of pulmonary exacerbations and underweight condition in cystic fibrosis (CF) patients have become tools that are used in many cystic fibrosis centres, The experience with home care programmes from different countries is quite

  4. Self-management education for cystic fibrosis.

    LENUS (Irish Health Repository)

    Savage, Eileen

    2011-01-01

    Self-management education may help patients with cystic fibrosis and their families to choose, monitor and adjust treatment requirements for their illness, and also to manage the effects of illness on their lives. Although self-management education interventions have been developed for cystic fibrosis, no previous systematic review of the evidence of effectiveness of these interventions has been conducted.

  5. Laparoscopic cholecystectomy in adult cystic fibrosis.

    LENUS (Irish Health Repository)

    McGrath, D S

    2012-02-03

    Two female patients with Cystic Fibrosis, attending the Adult Regional Cystic Fibrosis centre at the Cork University Hospital, were investigated for upper abdominal pain and found to have gallstones at ultrasonography. Laparoscopic cholecystectomy was performed successfully and, without complication, in both patients.

  6. [Non-invasive assessment of liver fibrosis].

    Science.gov (United States)

    Cohen-Ezra, Oranit; Ben-Ari, Ziv

    2015-03-01

    Chronic liver diseases represent a major public health problem, accounting for significant morbidity and mortality worldwide. Prognosis and management of chronic liver diseases depend on the amount of liver fibrosis. Liver biopsy has long remained the gold standard for assessment of liver fibrosis. Liver biopsy is an invasive procedure with associated morbidity, it is rarely the cause for mortality, and has a few limitations. During the past two decades, in an attempt to overcome the limitations of liver biopsy, non-invasive methods for the evaluation of liver fibrosis have been developed, mainly in the field of viral hepatitis. This review will focus on different methods available for non-invasive evaluation of liver fibrosis including a biological approach which quantifies serum levels of biomarkers of fibrosis and physical techniques which measure liver stiffness by transient elastography, ultrasound or magnetic resonance based elastography, their accuracy, advantages and disadvantages.

  7. Evidence for a Cystic Fibrosis Enteropathy.

    Directory of Open Access Journals (Sweden)

    Marlou P M Adriaanse

    Full Text Available Previous studies have suggested the existence of enteropathy in cystic fibrosis (CF, which may contribute to intestinal function impairment, a poor nutritional status and decline in lung function. This study evaluated enterocyte damage and intestinal inflammation in CF and studied its associations with nutritional status, CF-related morbidities such as impaired lung function and diabetes, and medication use.Sixty-eight CF patients and 107 controls were studied. Levels of serum intestinal-fatty acid binding protein (I-FABP, a specific marker for enterocyte damage, were retrospectively determined. The faecal intestinal inflammation marker calprotectin was prospectively studied. Nutritional status, lung function (FEV1, exocrine pancreatic insufficiency (EPI, CF-related diabetes (CFRD and use of proton pump inhibitors (PPI were obtained from the medical charts.Serum I-FABP levels were elevated in CF patients as compared with controls (p<0.001, and correlated negatively with FEV1 predicted value in children (r-.734, p<0.05. Faecal calprotectin level was elevated in 93% of CF patients, and correlated negatively with FEV1 predicted value in adults (r-.484, p<0.05. No correlation was found between calprotectin levels in faeces and sputum. Faecal calprotectin level was significantly associated with the presence of CFRD, EPI, and PPI use.This study demonstrated enterocyte damage and intestinal inflammation in CF patients, and provides evidence for an inverse correlation between enteropathy and lung function. The presented associations of enteropathy with important CF-related morbidities further emphasize the clinical relevance.

  8. Interactive radio in the classroom: ten years of proven success.

    Science.gov (United States)

    Imhoof, M

    1985-01-01

    Interactive instructional radio programming is an innovative, inexpensive, and highly effective educational tool. In interactive radio programming, lessons are provided by a radio instructor, but unlike other radio education programs, the instructor prompts responses from the radio audience, provides pauses for audience responses, and then supplies the correct response to the prompt. The lessons are generally supervised by a classroom teacher, and the students respond to the radio prompts either orally or in writing. The lessons encourage student participation, and the programs frequently require more than 100 audience responses for each 1/2 hour of radio programing. The US Agency for International Development's Office of Education in the Bureau for Science and Technology researched and developed the tool during the last 10 years, and conducted highly successful experimental projects with it in Kenya, Nicaragua, and the Dominican Republic. In September 1984 a conference, jointly sponsored by the agency and Kenya's Ministry of Education, Science, and Technology, was held in Nairobi to demonstrate the new tool and to encourage other countries to utilize the approach. Participants visited rural classrooms in Kenya where they had an opportunity to observe how the technique was being successfully used in Kenya's Radio Language Arts Project. In view of the successful results attained in the experimental projects of the 3 countries noted above, the conference participants recommended that the technique should immediately be integrated into the national curricula of these countries, and that the approach should be more widely used in other countries. They noted that the technique is especially appropriate for use in primary schools and in nonformal adult education programs and that the tool is especially useful for teaching mathematics and second languages. They recommended that educators in developing countries develop interactive instructional radio programs, evaluate these programs, and then integrate the approach in the school curriculum. The participants noted that the technique can serve to upgrade the quality of classroom teaching and that the approach can be also used to provide teachers with inservice training. They further recommended that administrators and parents should be provided with information about the technique and its advantages, and that efforts should be made to immediately promote its use.

  9. Ten years of transition and... / Rika Ishii, Nick Sten

    Index Scriptorium Estoniae

    Ishii, Rika

    1999-01-01

    Ülevaade majandusreformidest Baltimaades ja Baltimaade majandussuhetest Euroopa Liidu ning Venemaaga. Tabel: SKP, inflatsioon, väliskaubandus ja välisinvesteeringud Eestis, Lätis, Leedus ja Kesk- ja Ida-Euroopa riikides aastatel 1991-1998

  10. Research, records and responsibility ten years of PARADISEC

    CERN Document Server

    Harris, Amanda

    2015-01-01

    Research, records and responsibility' explores developments in collaborative archiving practice between archives and the communities they serve and represent, incorporating case studies of historical recordings, visual data and material culture.

  11. 1959 - 1969 Ten years in the life of a machine

    CERN Multimedia

    1969-01-01

    Operation and development of the PS have brought a dramatic improvement in its capabilities. This article describes the years of getting to know the machine and of developing its potential, picking out some major landmarks on the way. The article was put together with the help of P.H. Standley (PS Division Head), C.S. Taylor (Linac), G. Plass, W. Richter (Mam Ring), M. Georgijevic (Power Supply), J.H.B. Madsen (Operation), and G.L. Munday (Experimental Areas).

  12. Laser Fusion: The First Ten Years 1962-1972

    Energy Technology Data Exchange (ETDEWEB)

    Kidder, R E

    2006-07-06

    This account of the beginning of the program on laser fusion at Livermore in 1962, and its subsequent development during the decade ending in 1972, was originally prepared as a contribution to the January 1991 symposium 'Achievements in Physics' honoring Professor Keith Brueckner upon his retirement from the University of San Diego at La Jolla. It is a personal recollection of work at Livermore from my vantage point as its scientific leader, and of events elsewhere that I thought significant. This period was one of rapid growth in which the technology of high-power short-pulse lasers needed to drive the implosion of thermonuclear fuel to the temperature and density needed for ignition was developed, and in which the physics of the interaction of intense light with plasmas was explored both theoretically and experimentally.

  13. Ten-Year-Old Students Solving Linear Equations

    Science.gov (United States)

    Brizuela, Barbara; Schliemann, Analucia

    2004-01-01

    In this article, the authors seek to re-conceptualize the perspective regarding students' difficulties with algebra. While acknowledging that students "do" have difficulties when learning algebra, they also argue that the generally espoused criteria for algebra as the ability to work with the syntactical rules for solving equations is…

  14. Ten years of the rational analysis of cognition.

    Science.gov (United States)

    Chater; Oaksford

    1999-02-01

    Rational analysis is an empirical program that attempts to explain the function and purpose of cognitive processes. This article looks back on a decade of research outlining the rational analysis methodology and how the approach relates to other work in cognitive science. We illustrate rational analysis by considering how it has been applied to memory and reasoning. From the perspective of traditional cognitive science, the cognitive system can appear to be a rather arbitrary assortment of mechanisms with equally arbitrary limitations. In contrast, rational analysis views cognition as intricately adapted to its environment and to the problems it faces.

  15. Floridi's "Open Problems in Philosophy of Information", Ten Years Later

    National Research Council Canada - National Science Library

    Gordana Dodig Crnkovic; Wolfgang Hofkirchner

    2011-01-01

      In his article Open Problems in the Philosophy of Information [1] Luciano Floridi presented a Philosophy of Information research program in the form of eighteen open problems, covering the following fundamental areas...

  16. The home-work balance of telecommuters: ten years after

    NARCIS (Netherlands)

    Casimir, G.J.

    2013-01-01

    In 2001, my doctoral dissertation on the impact of telecommuting on the division of labour in the domestic setting ended with the notion that boundaries between work and home are increasingly blurred. In this study, I investigated if this trend actually took place, by means of an analysis of

  17. Collection overview: ten years of wonderful open access science.

    Science.gov (United States)

    Roberts, Roland G; Alfred, Jane

    2013-10-01

    To mark our tenth Anniversary at PLOS Biology, we are launching a special, celebratory Tenth Anniversary PLOS Biology Collection which showcases 10 specially selected PLOS Biology research articles drawn from a decade of publishing excellent science. It also features newly commissioned articles, including thought-provoking pieces on the Open Access movement (past and present), on article-level metrics, and on the history of the Public Library of Science. Each research article highlighted in the collection is also accompanied by a PLOS Biologue blog post to extend the impact of these remarkable studies to the widest possible audience.

  18. Ten years of transition and... / Rika Ishii, Nick Sten

    Index Scriptorium Estoniae

    Ishii, Rika

    1999-01-01

    Ülevaade majandusreformidest Baltimaades ja Baltimaade majandussuhetest Euroopa Liidu ning Venemaaga. Tabel: SKP, inflatsioon, väliskaubandus ja välisinvesteeringud Eestis, Lätis, Leedus ja Kesk- ja Ida-Euroopa riikides aastatel 1991-1998

  19. Ten years on, the web spans the globe

    CERN Multimedia

    Dalton, A W

    2003-01-01

    Short article on the history of the WWW. Prof Berner-Lee states that one of the main reasons the web was such a success was due to CERN's decision to make the web foundations and protocols available on a royalty-free basis (1/2 page).

  20. Ten-year cardiovascular risk assessment in university students.

    Science.gov (United States)

    Uvacsek, Martina; Kneffel, Zs; Tóth, M; Johnson, A W; Vehrs, P; Myrer, J W; Hager, R

    2014-09-01

    Cardiovascular disease (CVD) is responsible for more than half of all deaths in the European region. The aim of the study was to compare body composition, blood pressure, total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C), family history, activity behaviors, and the 10-year risk of having a heart attack between 166 university students (21.62 ± 2.59 yrs) from Utah (USA) and 198 students (22.11 ± 2.51 yrs) from Hungary. Ninety-two percent of the Hungarian students and 100% of the Utah students had an estimated 10-year Framingham risk score of 1% or less. The high prevalence of low risk was primarily due to the young age of study participants, healthy body composition and non-smoking behavior. Hungarians who had higher 10-year risk of heart attack had significantly higher waist hip ratio (WHR), TC, diastolic blood pressure (DBP) and were smokers compared to those Hungarians with lower risk. The self-reported physical activity levels between the two groups of students were not different. In conclusion the young men and women who participated in this study were, for the most part healthy; however the smoking habits and the lower physical activity of the Hungarian students likely elevated their risk of CVD.

  1. NHS litigation in bariatric surgery over a ten year period.

    Science.gov (United States)

    Ratnasingham, Kumaran; Knight, James; Liu, Mamie; Karatsai, Eleni; Humadi, Samer; Irukulla, Shashi

    2017-04-01

    Negligence claims in the UK NHS has increased over the last 30 years. The aim of this present study was determine the number of claims and the cost of litigation in Bariatric Surgery and compare it to similar other specialties. Data was received from NHS Litigation Authority (NHSLA) in response to Freedom of Information data request. There was a total of 7 claims, of which 4 were successful. The total pay out sum was £210,000 in 10 years. This is a very low amount compared to other surgical specialties. This low level of litigation probably indicates that the current bariatric surgical services in the NHS are delivering safe care with good patient satisfaction. This needs to be carefully considered prior to changing the payment tariffs for bariatric surgery. Copyright © 2017 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

  2. Interventions and outcomes infetal hydrops - a ten year experience

    LENUS (Irish Health Repository)

    O'Sullivan, C

    2011-02-01

    Institute of Obstetricians & Gynaecologists, RCPI Four Provinces Meeting, Junior Obstetrics & Gynaecology Society Annual Scientific Meeting, Royal Academy of Medicine in Ireland Dublin Maternity Hospitals Reports Meeting, Nov 2010

  3. Ten Years of Tamoxifen Reduces Breast Cancer Recurrences, Improves Survival

    Science.gov (United States)

    ... Antonio Breast Cancer Symposium (SABCS) and published in The Lancet on December 5, 2012—are likely to change ... Cancer Center London in an accompanying editorial in The Lancet . "No data are available to suggest that [the ...

  4. US-Hungarian Relations Ten Years After 1956

    Directory of Open Access Journals (Sweden)

    Tibor Glant

    2016-10-01

    Full Text Available 1966, the tenth anniversary of the 1956 Revolution, was a key year in US–Hungarian relations. Diplomatic relations were raised from the lowest to the highest level, but suspicion and tension remained. Neither side knew what to expect from the other on account of the anniversary, the Vietnam War, economic and cultural negotiations, and the fate of Cardinal Mindszenty. A traditional diplomatic historical approach is supplemented here with cultural materials to present the full scale of contacts ranging from high political issues to the visit of Hollywood movie star Kirk Douglas in Budapest. First Secretary of the Legation for Press and Cultural Affairs Edward Alexander receives special attention, because he played a crucial role in the events of 1966. As press secretary, he helped calm Hungarian fears over what American journalists might report about the anniversary, while as cultural affairs officer he worked on documenting and expanding American cultural presence in Hungary. In the latter capacity, he opened the USIA Library at the Legation, fraternized with blacklisted painters of the Zuglói Kör [‘Zugló Circle’], monitored the Hungarian stage production of My Fair Lady, and reported on the publication of American literature in Hungarian.

  5. Ten-year survival of patients with oesophageal squamous cell ...

    African Journals Online (AJOL)

    [1] The outcome for ... survival after surgical resection of oesophageal SCC. ... the upper chest were performed for all tumours of the lower third ... clinicopathological characteristics of patients who were alive more than 10 years after oesophagectomy and .... series, 72 patients (6.9%) underwent neo-adjuvant therapy, and.

  6. Ten year neurocognitive trajectories in first-episode psychosis

    DEFF Research Database (Denmark)

    Barder, Helene E; Sundet, Kjetil; Rund, Bjørn R

    2013-01-01

    Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP) and the relationship to clinically significant subgroups even more so. We report 10 year longitud......Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP) and the relationship to clinically significant subgroups even more so. We report 10 year...... longitudinal neurocognitive development in a sample of FEP patients, and explore whether the trajectories of cognitive course are related to presence of relapse to psychosis, especially within the first year, with a focus on the course of verbal memory. Method: Forty-three FEP subjects (51% male, 28 ± 9 years...... of illness. We conclude that worsening of specific parts of cognitive function may be expected for patients with on-going psychosis, but that the majority of patients do not show significant change in cognitive performance during the first 10 years after being diagnosed....

  7. Vietnam 1963-1973: Ten Years of Operational Contract Support

    Science.gov (United States)

    2014-05-22

    determine which contractors operate within the market.29 This study uses the framework of the microeconomic phenomenon of monopsony to explain the...increases. Third, when the size of the military decreases, then the dependence on PMCs increases. In order to 27Edwin Mansfield, Microeconomics ...operates in an imbalanced market where the U.S. Government becomes the sole buyer on the demand side. This is a microeconomic phenomenon known as

  8. Predoctoral education in family medicine: a ten-year perspective.

    Science.gov (United States)

    Leaman, T L

    1979-11-01

    The educational goals chosen by teachers of family medicine for predoctoral students a decade ago differ substantially from the present goals. The original goals were to increase the number of family physicians, provide them with the basic knowledge and skills to practice, integrate the concepts of family medicine into the total medical school curriculum, and develop the "attitudes and ideals" of the good family physician. A series of basic learning principles were evolved to attain these goals. These included: teach in a practice setting, focus on persons rather than disease processes, use a team approach to teaching, involve students in the planning and evaluation process, and recognize curriculum development as a dynamic process. The present curriculum has an increased emphasis on clinical skills in family practice and on integration of behavioral science; there is a new emphasis on the role of the physician in the community and a better understanding of health care systems. Future directions for family medicine include increasing the emphasis on interpersonal communications, clinical synthesis, and clinical assessment.

  9. Ten-year experience of phototherapy in Yonsei Medical Center.

    Science.gov (United States)

    Park, S H; Hann, S K; Park, Y K

    1996-12-01

    Phototherapy with PUVA or UVB has been used to treat a wide variety of diseases such as psoriasis, vitiligo, atopic dermatitis and mycosis fungoides, etc. The present study was performed to investigate the pattern of phototherapy in the phototherapy clinic of Yonsei Medical Center. One thousand six hundred ninety two patients who received PUVA or UVB phototherapy were included in this study. We analyzed the protocols for phototherapy between 1985 and 1994. The number of phototherapy per year increased sharply until 1991 and thereafter it has remained relatively constant. The most common age group at the start of phototherapy was the third decade. The most common indications for PUVA and UVB phototherapy were vitiligo and psoriasis, respectively. Most patients had received less than 50 treatments of PUVA and less than 200 J/cm2 of cumulative UVA. Most patients had received less than 50 treatments with UVB and cumulative UVB doses were variable. We had not found any malignancy in the skin. Since the maximum safe cumulative doses of UVA or UVB have not yet been established, it is difficult to decide when phototherapy should be discontinued. The data presented in this study needs to be further analyzed in correlation with photoaging and cancer development for the safe usage of phototherapy.

  10. Ten-Year Study of a Wilson's Disease Dysarthric.

    Science.gov (United States)

    Day, Linda Susan; Parnell, Martha M.

    1987-01-01

    The 10-year longitudinal case study describes the history, speech therapy program, and treatment results for an adult male with Wilson's disease, a genetically based metabolic progressive neurological disorder which includes severe speech problems. (DB)

  11. Spitzoid Melanoma: A Ten Year-Old Boy

    Directory of Open Access Journals (Sweden)

    Işıl Kılınç Karaarslan

    2008-01-01

    Full Text Available Spitzoid melanoma is a rare variant of melanoma, in which the clinical and histopathologic diagnoses are difficult. Data on the features of Spitzoid melanoma in children is limited in the literature, since melanoma is rarely seen in childhood. Here, we report a 10 year-old child with a Spitzoid melanoma. By the means of this case, it has been emphasized that melanoma should be considered in the differential diagnosis of vascular lesions even seen in childhood, unless the clinical and dermoscopic features are characteristic for an entity. (Journal of Current Pediatrics 2008; 6: 127-9

  12. Ten years of Toarcian argillite - carbon steel in situ interaction

    Energy Technology Data Exchange (ETDEWEB)

    Dauzeres, Alexandre [IRSN, PRP-DGE/SRTG/LETIS, BP 17, 92262 Fontenay-aux-Roses cedex (France); Maillet, Anais [IRSN, PRP-DGE/SRTG/LETIS, BP 17, 92262 Fontenay-aux-Roses cedex (France); UMR CNRS 7285, IC2MP, Batiment B35 - 5, avenue Albert Turpain, 86022 Poitiers cedex (France); Gaudin, Anne [UMR CNRS 6112, LPGN, 2 rue de la Houssiniere, BP 92208, 44322 Nantes cedex 3 (France); El Albani, Abderrazak; Vieillard, Philippe [UMR CNRS 7285, IC2MP, Batiment B35 - 5, avenue Albert Turpain, 86022 Poitiers cedex (France)

    2013-07-01

    In situ interaction experiments over periods of 2, 6, and 10 years between Toarcian argillite and carbon steel discs were carried out in the Tournemire Underground Research Laboratory (URL), yielding a dataset of the materials' geochemical evolution under conditions representative of the future geological disposal of high-level long-lived radioactive wastes. The carbon steel discs were exposed to corrosion due to trapped oxygen. The corrosion rates indicate that the oxidizing transient lasted between 2 and 6 years. A systematic dissolution of calcium phases (Ca-smectite sheets in I/S and calcite) was observed in the iron diffusion halos. The iron release induced mineralogical dissolution and precipitation reactions, which partly clogged the argillite porosity. (authors)

  13. Sunspot Numbers from ISOON: A Ten-Year Data Analysis

    Science.gov (United States)

    Balasubramaniam, K. S.; Henry, T. W.

    2016-11-01

    Sunspot numbers are important tracers of historical solar activity. They are important in predicting the oncoming solar maximum, in the design of lifetimes of space assets, and in assessing the extent of solar-radiation impact on the space environment. Historically, sunspot numbers have been obtained visually from sunspot drawings. The availability of digital images from the US Air Force Improved Solar Optical Observing Network (ISOON) prototype telescope concurrent to observer-dependent sunspot numbers recorded at the National Solar Observatory (NSO) has provided a basis for comparing sunspot numbers determined from the two methods. We compare sunspot numbers from visual and digital methods observed nearly simultaneously. The advantages of digital imagery are illustrated.

  14. The cosmic dust analyser onboard cassini: ten years of discoveries

    Science.gov (United States)

    Srama, R.; Kempf, S.; Moragas-Klostermeyer, G.; Altobelli, N.; Auer, S.; Beckmann, U.; Bugiel, S.; Burton, M.; Economomou, T.; Fechtig, H.; Fiege, K.; Green, S. F.; Grande, M.; Havnes, O.; Hillier, J. K.; Helfert, S.; Horanyi, M.; Hsu, S.; Igenbergs, E.; Jessberger, E. K.; Johnson, T. V.; Khalisi, E.; Krüger, H.; Matt, G.; Mocker, A.; Lamy, P.; Linkert, G.; Lura, F.; Möhlmann, D.; Morfill, G. E.; Otto, K.; Postberg, F.; Roy, M.; Schmidt, J.; Schwehm, G. H.; Spahn, F.; Sterken, V.; Svestka, J.; Tschernjawski, V.; Grün, E.; Röser, H.-P.

    2011-12-01

    The interplanetary space probe Cassini/Huygens reached Saturn in July 2004 after 7 years of cruise phase. The German cosmic dust analyser (CDA) was developed under the leadership of the Max Planck Institute for Nuclear Physics in Heidelberg under the support of the DLR e.V. This instrument measures the interplanetary, interstellar and planetary dust in our solar system since 1999 and provided unique discoveries. In 1999, CDA detected interstellar dust in the inner solar system followed by the detection of electrical charges of interplanetary dust grains during the cruise phase between Earth and Jupiter. The instrument determined the composition of interplanetary dust and the nanometre-sized dust streams originating from Jupiter's moon Io. During the approach to Saturn in 2004, similar streams of submicron grains with speeds in the order of 100 km/s were detected from Saturn's inner and outer ring system and are released to the interplanetary magnetic field. Since 2004 CDA measured more than one million dust impacts characterising the dust environment of Saturn. The instrument is one of the three experiments which discovered the active ice geysers located at the south pole of Saturn's moon Enceladus in 2005. Later, a detailed compositional analysis of the water ice grains in Saturn's E ring system led to the discovery of large reservoirs of liquid water (oceans) below the icy crust of Enceladus. Finally, the determination of the dust-magnetosphere interaction and the discovery of the extended E ring (at least twice as large as predicted) allowed the definition of a dynamical dust model of Saturn's E ring describing the observed properties. This paper summarizes the discoveries of a 10-year story of success based on reliable measurements with the most advanced dust detector flown in space until today. This paper focuses on cruise results and findings achieved at Saturn with a focus on flux and density measurements. CDA discoveries related to the detailed dust stream dynamics, E ring dynamics, its vertical profile and E ring compositional analysis are published elsewhere (see Hus et al. in AIP Conference Proccedings 1216:510-513, 2010; Hsu et al. in Icarus 206:653-661, 2010; Kempf et al. in Icarus 193:420, 2008; 206(2):446, 2010; Postberg et al. in Icarus 193(2):438, 2008; Nature 459:1098, 2009; Nature, 2011, doi: 10.1038/nature10175).

  15. Analysis of ten years of publishing in Pharmacy Practice

    Directory of Open Access Journals (Sweden)

    Mendes AE

    2016-12-01

    Full Text Available Objective: The aim of this study is to characterize the patterns and trends in the editorial process and features of the first decade of Pharmacy Practice, with the final goal of initiating a benchmarking process to enhance the quality of the journal. Methods: Metadata of all of the articles published from 2006 issue #3 to 2016 issue #2 were extracted from PubMed and complemented by a manual data extraction process on the full-text articles. Citations of these articles were retrieved from Web of Science (WOS, Scopus, and Google Scholar on August 15, 2016. The references from all of the articles published by Pharmacy Practice in 2015 were also extracted. International collaboration was explored with a network analysis. Results: A total of 40 issues were published in this timespan, including 349 articles, 91.1% of which were original research articles. The number of citations received by these articles varies from 809, as reported by the WOS, to the 1162 reported by Scopus and the 2610 reported by Google Scholar. The journals cited by Pharmacy Practice are mainly pharmacy journals, including Pharm Pract (Granada, Int J Clin Pharm, Am J Health-Syst Pharm, Am J Pharm Educ, and Ann Pharmacother. Only 17.3% of the articles involved international collaboration. Delays in the editorial process increased in 2013, mainly due to an increase in acceptance delay (mean=138 days. Conclusion: Pharmacy Practice has improved its visibility and impact over the past decade, especially after 2014, when the journal became indexed in PubMed Central. The editorial process duration is one of the weaknesses that should be tackled. Further studies should investigate if the low international collaboration rate is common across other pharmacy journals.

  16. Ten Years in the Academic Integrity Trenches: Experiences and Issues

    Science.gov (United States)

    Atkinson, Doug; Nau, S. Zaung; Symons, Christine

    In 2016, our university launched its Academic Integrity Program (AIP) in order to promote and protect academic integrity. All commencing students must complete this online AIP within 14 days of starting their course. Satisfactory completion of this module with a test score of 80% is required before students can access their course materials.…

  17. Ten years of transition Stiglitz's criticism and counterarguments

    Directory of Open Access Journals (Sweden)

    Đurđević Ljiljana

    2004-01-01

    Full Text Available IMF supports the transition process in most ex-socialist countries through concessionary financing, recommendations for economic policy and technical assistance. Results vary across countries and have been analyzed by a number of authors. In this context, some authors have dealt with the IMF's "guilt" Stiglitz's criticism having struck the most responsive chord in public triggering violent reactions. The paper deals with the key hypotheses of this criticism as well as the main counter arguments.

  18. The Gestational Trophoblastic Diseases: A Ten Year Retrospective Study

    Directory of Open Access Journals (Sweden)

    Razieh Mohammadjafari

    2010-01-01

    Full Text Available Background: Gestational trophoblastic disease (GTD defines a heterogenenous group ofinterrelated lesions that arise from the trophoblastic epithelium of the placenta. There are severalhistologically distinct types of GTD: hydatiform mole (complete or partial, persistant/invasivegestational trophoblastic neoplasia (GTN, choriocarcinoma and placenta site trophoblastictumors. The aim of this study was to determine the frequency and risk factors of GTD amongwomen admitted to Imam Khomeini Hospital in Ahvaz, Iran.Materials and Methods: This was a cross-sectional study conducted at Imam KhomeiniHospital in Ahvaz, Iran. All hospital records related to GTD (132 from 1996 until 2006 werereviewed. Demographic and histo-pathologic characteristics were extracted. Chi-square andFisher-exact tests were used to analyze all variables. P ≤ 0.05 was considered statisticallysignificant. SPSS, version 11 was used for statistical analysis.Results: The mean age of patients was 27.6 years. Most patients who presented with GTDwere of ages 18-35 years (71.3%. There was no relationship between age and hydatiformmole during the reproductive years. There were 28 (18.9% patients over the age 40, of which18 (15.90% of these had a complete hydatiform mole. Within this group, 9 (6.8% changedto a persistent mole. There was a significant relationship between age over 40 and completemole (p<0.02. The percentage of patients with blood groups A and O was the same (37.9%.There was a significant relationship between blood groups (O+ and A+ and complete mole(p<0.05.Conclusion: The most common age range for hydatiform mole was 18-35 years. Women overthe age of 40 had a more complete hydatiform mole, which is similar to the other countries.Age and blood group are two risk factors for hydatiform mole.

  19. Chandra: Ten Years of Amazing Science with a Great Observatory

    Science.gov (United States)

    Weisskopf, Martin C.

    2009-01-01

    We review briefly review the history of the development of the Chandra X-Ray Observatory, highlighting certain details that many attendees of this Conference might not be aware of. We then present a selection of scientific highlights of the first 10 years of this remarkable and unique mission.

  20. Ten Years of Cloud Optical and Microphysical Retrievals from MODIS

    Science.gov (United States)

    Platnick, Steven; King, Michael D.; Wind, Galina; Hubanks, Paul; Arnold, G. Thomas; Amarasinghe, Nandana

    2010-01-01

    The MODIS cloud optical properties algorithm (MOD06/MYD06 for Terra and Aqua MODIS, respectively) has undergone extensive improvements and enhancements since the launch of Terra. These changes have included: improvements in the cloud thermodynamic phase algorithm; substantial changes in the ice cloud light scattering look up tables (LUTs); a clear-sky restoral algorithm for flagging heavy aerosol and sunglint; greatly improved spectral surface albedo maps, including the spectral albedo of snow by ecosystem; inclusion of pixel-level uncertainty estimates for cloud optical thickness, effective radius, and water path derived for three error sources that includes the sensitivity of the retrievals to solar and viewing geometries. To improve overall retrieval quality, we have also implemented cloud edge removal and partly cloudy detection (using MOD35 cloud mask 250m tests), added a supplementary cloud optical thickness and effective radius algorithm over snow and sea ice surfaces and over the ocean, which enables comparison with the "standard" 2.1 11m effective radius retrieval, and added a multi-layer cloud detection algorithm. We will discuss the status of the MOD06 algorithm and show examples of pixellevel (Level-2) cloud retrievals for selected data granules, as well as gridded (Level-3) statistics, notably monthly means and histograms (lD and 2D, with the latter giving correlations between cloud optical thickness and effective radius, and other cloud product pairs).