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Sample records for fibras musculares lisas

  1. Sistema de reforço à punção de lajes lisas de concreto armado com polímeros reforçados com fibra de carbono (PRFC

    Directory of Open Access Journals (Sweden)

    G. S. Santos

    Full Text Available Este artigo apresenta um estudo analítico de uma recente técnica de reforço de lajes lisas de concreto armado contra o fenômeno da punção. Trata-se da utilização de mantas de Polímeros Reforçados com Fibra de Carbono (PRFC como armadura de cisalhamento. O sistema, denominado Stitch, foi idealizado por Sissakis (2002 [1] e consiste em se formar um laço completo entre dois furos subsequentes como pontos de costura . O objetivo deste artigo é avaliar a aplicação de adaptações das principais normas, nacional e internacionais, de dimensionamento à punção de lajes com pilar interno, sem a atuação de momentos fletores e associadas às limitações do ACI 440 2R:2008 [6], a qual trata do reforço de estruturas com PRFC. Os Resultados mostram que a NBR 6118:2007 [4] apresentou o menor grau de dispersão, com alguns resultados contra a segurança. O ACI 318:2011 possui uma tendência mais conservadora, e o EUROCODE 2:2004 [4] e Model Code (2010 [5] possuem resultados intermediários, com esse ligeiramente mais conservador que aquele.

  2. Influência da progressão do diabetes nos padrões dinâmicos de recrutamento de fibras musculares analisados através de eletromiografia de alta densidade

    OpenAIRE

    Marco Kenji Butugan

    2014-01-01

    Este estudo teve como objetivo investigar a influência de diferentes estágios de severidade da neuropatia diabética na velocidade de condução das fibras musculares estimada em quatro músculos do membro inferior durante contrações isométricas, utilizando-se eletromiografia de superfície. Oitenta e cinco adultos foram estudados: 16 indivíduos não diabéticos e 69 diabéticos classificados em quatro estágios de neuropatia definidos por um sistema fuzzy: ausente (n=26), leve (n=21), moderada (n=11)...

  3. Tumor misto de células musculares lisas e do estroma endometrial uterino: relato de caso Mixed endometrial stromal and smooth muscle tumor of the uterus: case report

    Directory of Open Access Journals (Sweden)

    Luiz Gustavo Oliveira Brito

    2012-12-01

    Full Text Available Os tumores mistos de células musculares lisas e do estroma endometrial uterino, caracterizados pela presença de componentes de ambas as linhagens, coexistindo em proporções quase equivalentes, são neoplasmas raros. Possuem potencial biológico incerto e se comportam de acordo com o componente estromal. A imuno-histoquímica é uma grande aliada no diagnóstico microscópico, pois a clínica e os exames de imagem não ajudam a diferenciá-los de outras doenças uterinas. Descrevemos o caso de uma paciente cuja hipótese diagnóstica era de leiomioma uterino e que, após cirurgia, foi diagnosticada pelo estudo anatomopatológico como tumor misto de células musculares lisas e do estroma endometrial uterino.Mixed tumors of uterine smooth muscle and endometrial stromal cells, which are characterized by the presence of components from both cell lineages with similar proportions, are rare neoplasms. Their biological potential is uncertain, and they behave according to the stromal component. Immunohistochemistry is an important ally in microscopic diagnosis, because symptoms and imaging exams do not help in the differentiation from other uterine diseases. We describe a case of a patient who had been previously diagnosed with uterine leiomyoma, and after surgery, the anatomopathological study revealed a mixed tumor of uterine smooth muscle and endometrial stromal cells.

  4. Rightsizing LISA

    International Nuclear Information System (INIS)

    Stebbins, R T

    2009-01-01

    The Laser Interferometer Space Antenna (LISA) science requirements and conceptual design have been fairly stable for over a decade. In the interest of reducing costs, the LISA Project at NASA has looked for simplifications of the architecture, at downsizing of subsystems and at descopes of the entire mission. This is a natural activity of the formulation phase and one that is particularly timely in the current NASA budgetary context. There is, and will continue to be, enormous pressure for cost reduction from both ESA and NASA, reviewers and the broader research community. Here, the rationale for the baseline architecture is reviewed, and recent efforts to find simplifications and other reductions that might lead to savings are reported. A few possible simplifications have been found in the LISA baseline architecture. In the interest of exploring cost sensitivity, one moderate and one aggressive descope have been evaluated; the cost savings are modest and the loss of science is not.

  5. Efeito da Temperatura Ambiente e da Restrição Alimentar sobre o Desempenho e a Composição de Fibras Musculares Esqueléticas de Frangos de Corte

    Directory of Open Access Journals (Sweden)

    Sartori José Roberto

    2001-01-01

    Full Text Available O objetivo desta pesquisa foi estudar os efeitos da temperatura ambiente e da restrição alimentar sobre o desempenho e a composição do músculo flexor longo do hálux de frangos de corte. Trezentos e vinte e quatro pintos machos da linhagem Ross, com cinco dias de idade, foram distribuídos em um delineamento em parcelas subdivididas, considerando os tratamentos principais no esquema fatorial 3x3 inteiramente casualizado (três programas de alimentação: ad libitum, restrição precoce - 8 a 14 dias e restrição tardia - 29 a 35 dias; três níveis de temperatura: termoneutra, calor e frio. Os tratamentos secundários foram as idades das aves (seis idades: 7, 14, 21, 28, 35 e 42 dias. Não houve interação entre programa de alimentação e temperatura ou entre programa de alimentação, temperatura e idade para as características de desempenho dos frangos. Independentemente do programa de alimentação, houve efeito de temperatura para peso, ganho de peso, consumo de ração e conversão alimentar. O programa de alimentação afetou o peso e o ganho de peso das aves. Houve interação entre programa de alimentação e idade e entre temperatura e idade para peso vivo ao abate e peso do músculo da perna direita. Estas interações não foram significativas para peso do músculo da perna esquerda, área da secção transversal do músculo e relação peso do músculo/peso vivo ao abate. Conclui-se que a temperatura ambiente afeta o desempenho dos frangos de corte, porém não altera o número, diâmetro e freqüência de fibras musculares no músculo flexor longo do hálux. A restrição alimentar precoce pode ser adotada como prática de manejo, sem que se observem alterações do desempenho na idade de abate e nem na composição das fibras musculares esqueléticas dos frangos de corte.

  6. Desempenho, fibras musculares e carne de bovinos jovens de três grupos genéticos Performance, muscle fibers and meat traits of young bulls of three genetic groups

    Directory of Open Access Journals (Sweden)

    Mário De Beni Arrigoni

    2004-10-01

    Full Text Available O objetivo deste trabalho foi avaliar as características de desempenho, carcaça, qualidade de carne e das fibras musculares esqueléticas de bovinos jovens de três grupos genéticos, Angus x Nelore, Canchim x Nelore e Simental x Nelore. Noventa bovinos inteiros mestiços jovens, com idade média de oito meses, sendo 30 de cada grupo genético, foram distribuídos em delineamento experimental inteiramente casualizado, com três tratamentos (grupos genéticos e seis repetições. Nas análises das fibras musculares, foram utilizados seis animais por tratamento e na avaliação de desempenho e características de carcaça, foram utilizados todos os animais. Em relação a ganho de peso diário, rendimentos de carcaça e cortes cárneos, área do músculo longissimus dorsi e proteínas e lipídeos totais na carne, não houve diferença entre os grupos genéticos, porém os mestiços Angus apresentaram maior espessura de gordura subcutânea. A maciez da carne não variou entre os grupos genéticos e entre os períodos de 7 e 14 dias de maturação. A semelhança da maciez da carne de 7 e 14 dias permite que o tempo de maturação das carnes seja reduzido, quando se utiliza animais jovens.The performance, carcass traits and quality of meat and muscle fibers of young bulls of three genetic groups, Angus x Nelore, Canchim x Nelore and Simmental x Nelore, were analysed. Ninety crossbred young bulls, averaging eight months old, being 30 of each genetic group, were allotted in a completely randomized design, with three treatments (genetic groups and six replicates. Six animals per treatment were used for the analysis of muscular fibers, while for the evaluation of performance and carcass traits, all animals were used. Average daily gain, dressing percentage, primal cuts yield, rib eye area and total meat protein and fat did not differ among treatments. Angus crossbreed showed greater fat thickness than the other groups. Meat shear force values did not

  7. Influence of feeding regime and finishing system on lamb muscle fiber and meat quality Influência do regime alimentar e do sistema de terminação sobre as fibras musculares e a qualidade da carne de cordeiros

    Directory of Open Access Journals (Sweden)

    Sarita Bonagurio Gallo

    2009-11-01

    Full Text Available The study verified the influence of different nutritional levels of the dams, before parturition, the weaning age of the lambs and the finishing system on lamb muscle fiber morphology and meat quality. Ile-de-France × Bergamacia crossbred dams grazing on natural grassland were divided into two groups: 1 nutritional supplement 30 days before the parturition (SUPL, and 2 no nutritional supplement (NS. These groups were further subdivided by weaning age of the lambs, which corresponded to either 45 or 60 days. The weaned lambs from each of the previous groups were also divided into different finishing systems: confined and fed a complete diet (CD, confined and fed hay (H and kept on grassland (P. The lambs were slaughtered at 30 kg live weight (CD and P, or at 150 days of age (H. The carcasses were cooled at 4ºC/24h. The analyzed variables were: longissimus dorsi muscle fiber morphophysiology, post mortem myofibrillar fragmentation (at 0, 3 and 7 days post mortem, meat pH and temperature. There was no effect of supplementation of dams or weaning age of the lambs for the evaluated variables. The frequency of slow-oxidative (SO, fast-oxidative-glycolytic (FOG and fast-glycolytic (FG muscle fiber types was not altered by the treatments, but the fiber cross-sectional area was smaller for the lambs finished only on hay, and the meat pH values and temperature were lower and the myofibrill fragment dimensions were smaller. As time maturation increased from 0 to 3 and 7 days post mortem, there was a decrease in the length of the myofibrill fragments. The diet of the lambs which were maintained confined and fed only with hay was nutritionally inferior when compared with all the others, and this changed the quality of the meat compared to the finishing systems on grassland or confined and fed complete diet.Avaliou-se a influência dos níveis nutricionais da ovelha antes do parto, da idade à desmama e do sistema de terminação sobre as fibras musculares

  8. Desempenho e características das fibras musculares esqueléticas de cordeiros nascidos de ovelhas que receberam suplementação alimentar em diferentes períodos da gestação Performance and skeletal muscular fiber characteristics of lambs born from ewes supplemented at different stages of pregnancy

    Directory of Open Access Journals (Sweden)

    Alexandre Agostinho Mexia

    2006-08-01

    Full Text Available Avaliou-se o desenvolvimento ponderal do nascimento ao desmame e o diâmetro e número de fibras musculares do músculo Semitendinosus de cordeiros filhos de ovelhas Santa Inês que receberam suplementação alimentar em diferentes períodos da gestação. Foram utilizadas 73 ovelhas Santa Inês (peso médio de 45,11 kg cobertas com três reprodutores Dorset, distribuídas entre os seguintes tratamentos durante a gestação: controle - pastagem de capim-tanzânia (Panicum maximum Jacq. e resíduo de mandioca durante toda a gestação; terço inicial - tratamento controle + suplementação do 1º ao 50º dia de gestação; terço médio (TM - tratamento controle + suplementação do 50º ao 100º dia de gestação; e terço final (TF - tratamento controle + suplementação do 100º dia de gestação até parição. Os nascimentos ocorreram no período de 23 de novembro de 2003 a 03 de janeiro de 2004. Os tratamentos não influenciaram o peso dos cordeiros ao nascimento (PCN, aos 30 dias de idade (PC30 e ao desmame (PC60 e o ganho médio diário do nascimento ao desmame (GMD 0-60, cujos valores médios foram de 4,02; 9,19; 16,40 e 0,21 kg/dia, respectivamente. O tipo de parto influenciou o PCN, PC30, PC60 e o GMD 0-60. Não houve diferença no diâmetro das fibras musculares ao nascimento (média de 11,61 µm e ao desmame (27,65 µm. O valor médio do número de fibras no músculo Semitendinosus foi de 1.454.185, o peso do músculo de 21,04 g e o comprimento de 8,43 cm, sendo semelhantes entre os períodos de suplementação. Não se justifica a suplementação de ovelhas nos diferentes períodos da gestação quando mantidas em pastagens de capim-tanzânia recebendo resíduo de fécula de mandioca no cocho.The objective of this trial was to evaluate the body weight change as well as the diameters and numbers of muscular fibers of the Semitendinosus muscle of lambs from birth until weaning that were born from Santa Inês ewes supplemented at

  9. Caracterização das fibras musculares do músculo Semitendinosus de bezerros mestiços Angus-Nelore recebendo somatotropina bovina recombinante (rbST até a desmama Characterization of Semitendinosus muscle fibers in pre-weaning Angus-Nellore crossbred calves receiving recombinant bovine somatotropin (rbST

    Directory of Open Access Journals (Sweden)

    Rafael da Costa Cervieri

    2005-06-01

    Full Text Available Objetivando-se estudar o efeito da somatotropina bovina recombinante (rbST sobre a freqüência de distribuição e o diâmetro das fibras musculares do músculo Semitendinosus, 36 bezerros mestiços ½Angus-Nelore, com idade inicial de 63 ± 17 dias e pesando 76,8 ± 14,7 kg, criados em pastagem de Brachiaria decumbens e suplementados em creep feeding, foram submetidos a dois tratamentos até a desmama (217 dias: 18 bezerros receberam 1,4 mg/kg de rbST (Boostin® a cada 14 dias e 18 receberam solução salina (controle. As amostras de músculo foram coletadas aos 117 (biópsia e aos 217 dias de idade, quando foram abatidos cinco animais por tratamento. Os animais suplementados apresentaram maior diâmetro para as fibras do tipo glicolítica de contração rápida (FG aos 117 dias e tendência de aumento aos 217 dias e não diferiram em relação ao grupo controle quanto ao diâmetro das fibras oxidativas-glicolíticas de contração rápida (FOG e oxidativas de contração lenta (SO e à frequência de FG, FOG e SO aos 117 e 217 dias de idade. Independentemente da aplicação de rbST, houve significativo aumento do diâmetro das fibras SO e FOG, tendência de aumento de diâmetro das fibras FG, maior frequência de SO e redução da frequência de FG entre 117 e 217 dias de idade. A utilização de somatotropina exógena possibilitou maior hipertrofia das fibras musculares brancas de contração rápida em bezerros suplementados em creep feeding durante a fase de cria, sem interferir na frequência de distribuição dos tipos de fibras no músculo Semitendinosus.The objective of this experiment was to study the effect of the recombinant bovine somatotropin (rbST on the percentage distribution and diameter of semitendinosus muscle fibers. Thirty-six ½ Angus-Nellore crossbred bull calves, 63 ± 17 days old and weighting 76.8 ± 14.7 kg, raised in Brachiaria decumbens pastures and creep fed, were assigned to one of two treatments until weaning

  10. The LISA Pathfinder Mission

    International Nuclear Information System (INIS)

    Armano, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Baird, J; Bortoluzzi, D; Brandt, N; Fitzsimons, E; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Dunbar, N; Ferraioli, L

    2015-01-01

    LISA Pathfinder (LPF), the second of the European Space Agency's Small Missions for Advanced Research in Technology (SMART), is a dedicated technology validation mission for future spaceborne gravitational wave detectors, such as the proposed eLISA mission. LISA Pathfinder, and its scientific payload - the LISA Technology Package - will test, in flight, the critical technologies required for low frequency gravitational wave detection: it will put two test masses in a near-perfect gravitational free-fall and control and measure their motion with unprecedented accuracy. This is achieved through technology comprising inertial sensors, high precision laser metrology, drag-free control and an ultra-precise micro-Newton propulsion system. LISA Pathfinder is due to be launched in mid-2015, with first results on the performance of the system being available 6 months thereafter.The paper introduces the LISA Pathfinder mission, followed by an explanation of the physical principles of measurement concept and associated hardware. We then provide a detailed discussion of the LISA Technology Package, including both the inertial sensor and interferometric readout. As we approach the launch of the LISA Pathfinder, the focus of the development is shifting towards the science operations and data analysis - this is described in the final section of the paper (paper)

  11. CABLES MUSCULARES

    Directory of Open Access Journals (Sweden)

    Alejandro Gómez

    Full Text Available Los cables musculares o fibras de nitinol presentan una excelente alternativa a los actuadores convencionales, con una fuerza de actuación muy alta, equivalente a la de los actuadores hidráulicos, proporcionalmente a su peso, además de su acción silenciosa. Este material, inventado en 1963, aún no es muy conocido y de ahí que se haya realizado una recopilación de sus propiedades. Entre ellas, la temperatura de transición es la más importante, por ser la que activa la aleación. Muchos sistemas se han creado para alcanzar adecuadamente la temperatura de transición, y también se continúa en la investigación de métodos que ayuden a lograr un control preciso del movimiento de la aleación con memoria de forma (SMA.

  12. LISA system design highlights

    Energy Technology Data Exchange (ETDEWEB)

    Sallusti, M [European Space Agency, ESTEC, Keplerlaan 1, 2200 AG Noordwijk ZH (Netherlands); Gath, P; Weise, D; Berger, M; Schulte, H R, E-mail: marcello.sallusti@esa.in, E-mail: peter.gath@astrium.eads.ne, E-mail: dennis.weise@astrium.eads.ne, E-mail: marcel.berger@astrium.eads.ne, E-mail: Hans.Reiner.Schulte@astrium.eads.ne [Astrium GmbH Satellites, Claude-Dornier-Str., 88039 Friedrichshafen (Germany)

    2009-05-07

    A contract, started in January 2005, was awarded to a consortium of Astrium GmbH and Astrium Ltd for the LISA Mission Formulation. The scope of the contract was the development of a reference design for the mission architecture and for the mission elements (with particular focus on the payload) and a successive phase of derivation of requirements, to be concluded with a mission design review. The technical starting point was the output of the previous LISA study formalized in the Final Technical Report, issued in the year 2000. During the design phase, different architecture concepts were identified and traded off, including the LISA orbits, the measurement scheme and the opto-mechanical architecture. During the Mission Design Review (July 2008) the consolidated mission baseline design, and the specifications of the flight elements and of the payload subsystem and major components were presented. This paper gives a brief overview of the major design points of the latest design of the LISA system.

  13. LISA system design highlights

    International Nuclear Information System (INIS)

    Sallusti, M; Gath, P; Weise, D; Berger, M; Schulte, H R

    2009-01-01

    A contract, started in January 2005, was awarded to a consortium of Astrium GmbH and Astrium Ltd for the LISA Mission Formulation. The scope of the contract was the development of a reference design for the mission architecture and for the mission elements (with particular focus on the payload) and a successive phase of derivation of requirements, to be concluded with a mission design review. The technical starting point was the output of the previous LISA study formalized in the Final Technical Report, issued in the year 2000. During the design phase, different architecture concepts were identified and traded off, including the LISA orbits, the measurement scheme and the opto-mechanical architecture. During the Mission Design Review (July 2008) the consolidated mission baseline design, and the specifications of the flight elements and of the payload subsystem and major components were presented. This paper gives a brief overview of the major design points of the latest design of the LISA system.

  14. LISA Pathfinder and eLISA news

    Science.gov (United States)

    Thorpe, James Ira; Mueller, Guido

    2014-01-01

    Two important gatherings of the space-based gravitational-wave detector community were held in Zurich, Switzerland this past March. The first was a meeting of the Science Working Team for LISA Pathfinder (LPF), a dedicated technology demonstrator mission for a future LISA-like gravitational wave observatory. LPF is entering an extremely exciting phase with launch less than 15 months away. All flight components for both the European science payload, known as the LISA Technology Package (LTP), and the NASA science payload, known as the Space Technology 7 Disturbance Reduction System (ST7-DRS), have been delivered and are undergoing integration. The final flight component for the spacecraft bus, a cold-gas thruster based on the successful GAIA design, will be delivered later this year. Current focus is on completing integration of the science payload (see Figures 1 and 2) and preparation for operations and data analysis. After a launch in Summer 2015, LPF will take approximately 90 days to reach its operational orbit around the Earth-Sun Lagrange point (L1), where it will begin science operations. After 90 days of LTP operations followed by 90 days of DRS operations, LPF will have completed its prime mission of paving the way for a space-based observatory of gravitational waves in the milliHertz band. Immediately following the meeting of the LPF team, the eLISA consortium held its third progress meeting. The consortium (www.elisascience.org) is the organizing body of the European space-based gravitational-wave community, and it was responsible for the "The Gravitational Universe" whitepaper that resulted in the November 2013 election of a gravitational-wave science theme for ESA's Cosmic Visions L3 opportunity. In preparation for an L3 mission concept call, which is expected later this decade, and for launch in the mid 2030s, the eLISA consortium members are coordinating technology development and mission study activities which will build on the LPF results. The final

  15. A lesão muscular na miastenia grave: estudo de 17 casos com histoquimica muscular

    Directory of Open Access Journals (Sweden)

    Lineu Cesar Werneck

    1982-03-01

    Full Text Available Estudo de 17 biópsias musculares de pacientes com miastenia grave, utilizando técnicas de coloração a fresco e histoquímica muscular. Foram encontradas 15 biópsias musculares anormais, sendo que as principais alterações foram fibras musculares angulares escuras atróficas, excesso de gotículas de gordura na membrana externa das fibras, variação no diâmetro das fibras e atrofia de fibras do tipo II. Os achados foram interpretados como denervação em 11 biópsias, atrofia de fibras do tipo II em 7, infiltrado linfocitário em 4, necrose de fibras musculares com fagocitose em 1 e em 2 biópsias não foi encontrada qualquer anormalidade. Quanto maior o tempo de doença, mais severa foi a anormalidade encontrada. Dois pacientes apresentavam timoma, um miastenia grave congênita, um artrite reumatoide, um neurite hipertrófica intersticial, um tireoidite de Hashimoto e um com síndrome miastênica concomitante. São discutidos os achados anatomopatológicos e sua possível explicação.

  16. Características das fibras musculares de cordeiros nascidos de ovelhas recebendo suplementação proteica no terço inicial da gestação Characteristics of muscle fibers of lambs born from sheep given protein suplementation in the intial third of pregnancy

    Directory of Open Access Journals (Sweden)

    Graziela Aparecida Santello

    2010-10-01

    Full Text Available Foram utilizadas 80 ovelhas Santa Inês, com 47,49 ± 3,76 kg de peso vivo, cobertas com reprodutores Dorper e alimentadas com concentrado com 15,20; 22,48; 26,52 e 35,65% de proteína bruta (PB no terço inicial de gestação. As ovelhas, durante o dia, permaneceram em pastagem de capim-aruana (Panicum maximum cv. Aruana. Ao nascimento, foram realizadas biópsias no músculo Semitendinosus esquerdo de cordeiros machos, para avaliar o número e o diâmetro das fibras musculares. Na fase de terminação, os cordeiros foram distribuídos em dois grupos e alimentados com uma dieta controle, contendo 16,18% de proteína bruta (PB e 79,64% nutrientes digestíveis totais (NDT, sem grão de girassol; ou com uma dieta contendo 9,10% de grãos de girassol (15,03% de PB e 78,96% de NDT. Não houve efeito da alimentação materna sobre o peso dos cordeiros ao nascimento (4,82 kg, aos 30 dias de idade (9,69 kg e ao desmame (15,38 kg. O sexo influenciou o peso dos cordeiros ao nascimento e ao desmame. O desempenho dos cordeiros na fase de terminação não foi influenciado pela dieta fornecida nessa fase, nem pelo sexo nem pelo manejo alimentar da mãe durante a gestação. Não houve diferença no número (2813,45 nem no diâmetro (13,16 μm das fibras musculares ao nascimento. O teor de PB de dietas para ovelhas no terço inicial da gestação pode ser reduzido, pois essa redução não influencia no diâmetro e número de fibras musculares.It was used 80 Santa Inês ewes with average body weight 47.79 ± 3.76 kg, mated with Dorper rams and fed concentrated diet with 15.20; 22.48; 26.52 and 35.65% crude protein (CP on the initial third of pregnancy. Sheep were kept on aruana grass (Panicum maximum cv. Aruana pasture during the day. At birth, biopsy on the left Semitendinosus muscle were done on male lambs to evaluate the number and diameter of muscular fibers. During finishing phase, lambs were distributed in two groups and fed control diet with 16

  17. LISA and asteroids

    International Nuclear Information System (INIS)

    Vinet, Jean-Yves

    2006-01-01

    LISA is a joint ESA-NASA mission aiming for cosmic gravitational wave detection and analysis. We address here the question of a special kind of signal caused by asteroid encounters. We present a short theory of the detection of such signals

  18. LISA and the LTP

    International Nuclear Information System (INIS)

    Jennrich, O.

    2002-01-01

    The primary objective of the LISA (Laser Interferometer Space Antenna mission is the detection and observation of gravitational waves from massive black holes (MBH) and galactic binaries in the frequency range 10 -4 Hz ... 10 -1 Hz. This low-frequency range is inaccessible to ground-based interferometers due to the background of local gravitational noise and because ground-based interferometers are limited in length to a few kilometres. LISA is envisaged as an ESA/NASA collaborative project, selected an ESA cornerstone mission and included in NASA's strategic plan and with a nominal launch date in 2011. SMART-2 is primarily intended to demonstrate the key technologies for the ESA/NASA collaborative LISA cornerstone mission. The synergy with the technology being used for Darwin motivates the utilization of SMART-2 for both missions. To this end, SMART-2 will accommodate a LISA technology package (LTP), provided by European institutes and industry and possibly also a Disturbance Reduction System (DRS) that is very similar to the LTP and has the same goals but is provided by US institutes and industry

  19. Synthetic LISA: Simulating time delay interferometry in a model LISA

    International Nuclear Information System (INIS)

    Vallisneri, Michele

    2005-01-01

    We report on three numerical experiments on the implementation of Time-Delay Interferometry (TDI) for LISA, performed with Synthetic LISA, a C++/Python package that we developed to simulate the LISA science process at the level of scientific and technical requirements. Specifically, we study the laser-noise residuals left by first-generation TDI when the LISA armlengths have a realistic time dependence; we characterize the armlength-measurement accuracies that are needed to have effective laser-noise cancellation in both first- and second-generation TDI; and we estimate the quantization and telemetry bitdepth needed for the phase measurements. Synthetic LISA generates synthetic time series of the LISA fundamental noises, as filtered through all the TDI observables; it also provides a streamlined module to compute the TDI responses to gravitational waves according to a full model of TDI, including the motion of the LISA array and the temporal and directional dependence of the armlengths. We discuss the theoretical model that underlies the simulation, its implementation, and its use in future investigations on system-characterization and data-analysis prototyping for LISA

  20. LISA Pathfinder: A Mission Status

    Science.gov (United States)

    Hewitson, Martin; LISA Pathfinder Team Team

    2016-03-01

    On December 3rd at 04:04 UTC, The European Space Agency launched the LISA Pathfinder satellite on board a VEGA rocket from Kourou in French Guiana. After a series of orbit raising manoeuvres and a 2 month long transfer orbit, LISA Pathfinder arrived at L1. Following a period of commissioning, the science operations commenced at the start of March, beginning the demonstration of technologies and methodologies which pave the way for a future large-scale gravitational wave observatory in space. This talk will present the scientific goals of the mission, discuss the technologies being tested, elucidate the link to a future space-based observatory, such as LISA, and present preliminary results from the in-orbit operations and experiments.

  1. Improving the sensitivity of LISA

    International Nuclear Information System (INIS)

    Nayak, K Rajesh; Pai, A; Dhurandhar, S V; Vinet, J-Y

    2003-01-01

    It has been shown in several recent papers that the six Doppler data streams obtained from a triangular LISA configuration can be combined by appropriately delaying the data streams for cancelling the laser frequency noise. Raw laser noise is several orders of magnitude above the other noises and thus it is essential to bring it down to the level of other noises such as shot, acceleration, etc. A rigorous and systematic formalism using the powerful techniques of computational commutative algebra was developed, which generates in principle all the data combinations cancelling the laser frequency noise. The relevant data combinations form a first module of syzygies. In this paper, we use this formalism to advantage for optimizing the sensitivity of LISA by analysing the noise and signal covariance matrices. The signal covariance matrix is calculated for binaries whose frequency changes at most adiabatically and the signal is averaged over polarizations and directions. We then present the extremal SNR curves for all the data combinations in the module. They correspond to the eigenvectors of the noise and signal covariance matrices. A LISA 'network' SNR is also computed by combining the outputs of the eigenvectors. We show that substantial gains in sensitivity can be obtained by employing these strategies. The maximum SNR curve can yield an improvement up to 70% over the Michelson, mainly at high frequencies, while the improvement using the network SNR ranges from 40% to over 100%. Finally, we describe a simple toy model, in which LISA rotates in a plane. In this analysis, we estimate the improvement in the LISA sensitivity, if one switches from one data combination to another as it rotates. Here the improvement in sensitivity, if one switches optimally over three cyclic data combinations of the eigenvector, is about 55% on average over the LISA bandwidth. The corresponding SNR improvement increases to 60%, if one maximizes over the module

  2. Molecular laser stabilization for LISA

    Science.gov (United States)

    Halloin, Hubert; Acef, Ouali; Argence, Berengere; Jeannin, Olivier; Prat, Pierre; de Vismes, Eden; Plagnol, Eric; Brillet, Alain; Mondin, Linda; Berthon, Jacques; Turazza, Oscar

    2017-11-01

    The expected performance of LISA relies on two main technical challenges: the ability for the spacecrafts to precisely follow the free-flying masses and the outstanding precision of the phase shift measurement. This latter constraint requires frequency stabilized lasers and efficient numerical algorithms to account for the redundant, delayed noise propagation, thus cancelling laser phase noise by many orders of magnitude (TDI methods). Recently involved in the technical developments for LISA, the goal of our team at APC (France) is to contribute on these two subjects: frequency reference for laser stabilization and benchtop simulation of the interferometer. In the present design of LISA, two stages of laser stabilization are used (not accounting for the "post-processed" TDI algorithm): laser pre-stabilization on a frequency reference and lock on the ultra stable distance between spacecrafts (arm-locking). While the foreseen (and deeply studied) laser reference consists of a Fabry-Perot cavity, other techniques may be suitable for LISA or future metrology missions. In particular, locking to a molecular reference (namely iodine in the case of the LISA Nd:YAG laser) is an interesting alternative. It offers the required performance with very good long-term stability (absolute frequency reference) though the reference can be slightly tuned to account for arm-locking. This technique is currently being investigated by our team and optimized for LISA (compactness, vacuum compatibility, ease of use and initialization, etc.). A collaboration with a French laboratory (the SYRTE) had been started aiming to study a second improved technique consisting in inserting the iodine cell in a Fabry-Perot cavity. Ongoing results and prospects to increase the performance of the system are presented in the present article.

  3. Laser modulator for LISA pathfinder

    Science.gov (United States)

    Voland, C.; Lund, G.; Coppoolse, W.; Crosby, P.; Stadler, M.; Kudielka, K.; Özkan, C.

    2017-11-01

    LISA Pathfinder is an ESA experiment to demonstrate the key technologies needed for the LISA mission to detect gravitational waves in space. The LISA Pathfinder spacecraft represents one arm of the LISA interferometer, containing an optical metrology system and two proof masses as inertial references for the drag-free control system. The LISA Pathfinder payload consists of two drag-free floating test masses located in the inertial sensors with their control electronics and an optical metrology subsystem. The optical metrology subsystem monitors the movement of both test masses relative to each other and to the spacecraft with very high sensitivity and resolution. This is achieved with a heterodyne Mach- Zehnder interferometer. This interferometer requires as input two coherent laser beams with a heterodyne frequency difference of a few kHz. To generate the two laser beams with a heterodyne frequency difference a Nd:YAG laser is used together with the Laser Modulator. The Nd:YAG laser generates a single coherent laser signal at a wavelength of 1064nm which is fibre coupled to the Laser Modulator. The Laser Modulator then generates the two optical beams with the required heterodyne frequency offset. In addition, the Laser Modulator is required to perform laser amplitude stabilization and optical path difference control for the two optical signals. The Laser Modulator consists of an optical unit - the LMU - and RF synthesiser, power amplification and control electronics. These electronics are all housed in the Laser Modulator Electronics (LME). The LMU has four primary functions: • Splitting of the input laser beam into two paths for later superposition in the interferometer. • Applying different frequency shifts to each of the beams. • Providing amplitude modulation control to each of the beams. • Providing active control of the optical path length difference between the two optical paths. The present paper describes the design and performance of the LMU

  4. Lisa Jevbratt / Lisa Jevbratt ; interv. Tilman Baumgärtel

    Index Scriptorium Estoniae

    Jevbratt, Lisa

    2006-01-01

    1967. a. Rootsis sündinud ja USA-s elavast kunstnikust Lisa Jevbrattist ning tema loomingust, 2000. a. jaanuaris tehtud meiliintervjuu kunstnikuga. L. Jevbratt kuulub rühmitusse C5, tema teosed keskenduvad pigem Interneti struktuurile kui selle sisule. Pikemalt võrguteosest "1:1" (2000), mille teemaks on IP-aadressid., lühidalt tööst "The Stillman Project" (1997), kunstniku galeriist "Non-Site"

  5. Micrometeorite Science with LISA Pathfinder

    Science.gov (United States)

    Pagane, Nicole; Thorpe, James Ira; Littenberg, Tyson; Littenberg, Tyson; Baker, John; Slutsky, Jacob; Hourihane, Sophie; LISA Pathfinder Team

    2018-01-01

    The primary objective of LISA Pathfinder (LPF) was to demonstrate drag-free control of test masses—along with the technology necessary to maintain the inertial motion—that LISA (Laser Interferometer Space Antenna) would later utilize as a space-based gravitational wave observatory. Due to the precise interferometry used during the mission, LPF could be employed as an accelerometer and used to detect micrometeorite impacts while in orbit about the Sun-Earth Lagrange Point L1. To infer micrometeorite impacts, the flight data was processed for event reconstruction to determine external acceleration of LPF; impact parameters were then estimated through a Markov-Chain Monte-Carlo (MCMC) tool via Bayesian analysis by fitting delta functions in the acceleration domain. As impact candidates were collected, a catalog of event data was curated with the reconstructed estimated parameters, among which were impact sky localizations that were later rotated into more intuitive reference frames. To infer the results of this dust modeling technique, current micrometeorite models were compared to the impact data. In the final reference frame common to the available micrometeorite models, the reconstructed impacts appear to cluster at (±90°, 0°)—where impacts prograde in this longitude-latitude frame were at (-90°, 0°), retrograde were (90°, 0°), and the sun was centered at the origin. The two available models used for comparison were of the Jupiter-family comets (JFC) and Halley-type comets (HTC), which clustered primarily around (±90°, 0°) and (0°, ±20°) respectively. This suggests that the JFC population seems to account for the majority of the impacts detected by LPF. The models’ expected rates given localization and velocity are currently being compared to the reconstructed data to further characterize the micrometeorite populations at L1. We will present our current analysis of this data set and discuss possibilities of extending such an analysis for LISA.

  6. LISA Pathfinder: OPD loop characterisation

    Science.gov (United States)

    Born, Michael; LPF Collaboration

    2017-05-01

    The optical metrology system (OMS) of the LISA Pathfinder mission is measuring the distance between two free-floating test masses with unprecedented precision. One of the four OMS heterodyne interferometers reads out the phase difference between the reference and the measurement laser beam. This phase from the reference interferometer is common to all other longitudinal interferometer read outs and therefore subtracted. In addition, the phase is fed back via the digital optical pathlength difference (OPD) control loop to keep it close to zero. Here, we analyse the loop parameters and compare them to on-ground measurement results.

  7. Observing a Gravitational Wave Background With Lisa

    National Research Council Canada - National Science Library

    Tinto, M; Armstrong, J; Estabrook, F

    2000-01-01

    ... formation of several observables. All are independent of lasers and frequency standard phase fluctuations, but have different couplings to gravitational waves and to the various LISA instrumental noises...

  8. Mona Lisa, lesbiahvid ja seksilaulud / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2003-01-01

    Ameerika Teaduse Edendamise Assotsiatsiooni (AAA) konverentsil esitatud uusimatest teadusuuringutest. Artiklid: Mona Lisa naeratuse saladus paljastatud ; Lesbilised Jaapani makaagid seljatavad Darwini ; Linnud õpivad uusi laule uue partneri leidmiseks

  9. Muscular Dystrophy

    Science.gov (United States)

    ... sets of muscles and cause different degrees of muscle weakness. Duchenne muscular dystrophy is the most common and the most severe ... can walk independently. Prednisone If a child has Duchenne muscular ... to help slow the rate of muscle deterioration. By doing so, the child may be ...

  10. LISA Pathfinder instrument data analysis

    Science.gov (United States)

    Guzman, Felipe

    LISA Pathfinder (LPF) is an ESA-launched demonstration mission of key technologies required for the joint NASA-ESA gravitational wave observatory in space, LISA. As part of the LPF interferometry investigations, analytic models of noise sources and corresponding noise subtrac-tion techniques have been developed to correct for effects like the coupling of test mass jitter into displacement readout, and fluctuations of the laser frequency or optical pathlength difference. Ground testing of pre-flight hardware of the Optical Metrology Subsystem is currently ongoing at the Albert Einstein Institute Hannover. In collaboration with NASA Goddard Space Flight Center, the LPF mission data analysis tool LTPDA is being used to analyze the data product of these tests. Furthermore, the noise subtraction techniques and in-flight experiment runs for noise characterization are being defined as part of the mission experiment master plan. We will present the data analysis outcome of pre-flight hardware ground tests and possible noise subtraction strategies for in-flight instrument operations.

  11. Lisa Woodward | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Lisa Woodward is Special Advisor to the President. Before joining IDRC, Lisa held positions in strategic planning, performance measurement, evaluation, risk management, and policy development in federal organizations, including Fisheries and Oceans Canada, the Canadian International Development Agency, and the ...

  12. LISA: Probing the Universe with Gravitational Waves

    NARCIS (Netherlands)

    Prince, T.A.; Binetruy, P.; Centrella, J.; Finn, L.S.; Hogan, C.; Nelemans, G.A.; Phinney, E.S.; Schutz, B.; Team, L.I.S.

    2006-01-01

    LISA is a joint NASA/ESA space mission for detection and study of low-frequency gravitational waves in the band from 0.1 mHz to 0.1 Hz. The mission consists of three satellites separated by a nominal distance of 5 million kilometers, with precision metrology provided by laser ranging. LISA will

  13. Black Holes, Gravitational Waves, and LISA

    Science.gov (United States)

    Baker, John

    2009-01-01

    Binary black hole mergers are central to many key science objectives of the Laser Interferometer Space Antenna (LISA). For many systems the strongest part of the signal is only understood by numerical simulations. Gravitational wave emissions are understood by simulations of vacuum General Relativity (GR). I discuss numerical simulation results from the perspective of LISA's needs, with indications of work that remains to be done. Some exciting scientific opportunities associated with LISA observations would be greatly enhanced if prompt electromagnetic signature could be associated. I discuss simulations to explore this possibility. Numerical simulations are important now for clarifying LISA's science potential and planning the mission. We also consider how numerical simulations might be applied at the time of LISA's operation.

  14. Muscular Dystrophy

    Science.gov (United States)

    ... Surveillance Tracking and Research Network , known as MD STAR net . Learn more about CDC’s other muscular dystrophy ... for Disease Control and Prevention Email Recommend Tweet YouTube Instagram Listen Watch RSS ABOUT About CDC Jobs ...

  15. Muscular dystrophy

    Science.gov (United States)

    ... are no known cures for the various muscular dystrophies. The goal of treatment is to control symptoms. Physical therapy may help maintain muscle strength and function. Leg braces and a wheelchair ...

  16. Possible LISA Technology Applications for Other Missions

    Science.gov (United States)

    Livas, Jeffrey

    2018-01-01

    The Laser Interferometer Space Antenna (LISA) has been selected as the third large class mission launch opportunity of the Cosmic Visions Program by the European Space Agency (ESA). LISA science will explore a rich spectrum of astrophysical gravitational-wave sources expected at frequencies between 0.0001 and 0.1 Hz and complement the work of other observatories and missions, both space and ground-based, electromagnetic and non-electromagnetic. Similarly, LISA technology may find applications for other missions. This paper will describe the capabilities of some of the key technologies and discuss possible contributions to other missions.

  17. Lisa's Lemonade Stand: Exploring Algebraic Ideas.

    Science.gov (United States)

    Billings, Esther M. H.; Lakatos, Tracy

    2003-01-01

    Presents an activity, "Lisa's Lemonade Stand," that actively engages students in algebraic thinking as they analyze change by investigating relationships between variables and gain experience describing and representing these relationships graphically. (YDS)

  18. Optimizing the Earth-LISA 'rendezvous'

    International Nuclear Information System (INIS)

    De Marchi, Fabrizio; Pucacco, Giuseppe; Bassan, Massimo

    2012-01-01

    We present a general survey of heliocentric LISA orbits, hoping that it might help in the exercise of rescoping the mission. We try to semi-analytically optimize the orbital parameters in order to minimize the disturbances coming from the Earth-LISA interaction. In a set of numerical simulations, we include non-autonomous perturbations and provide an estimate of Doppler shift and breathing as a function of the trailing angle. (paper)

  19. Novel Payload Architectures for LISA

    Science.gov (United States)

    Johann, Ulrich A.; Gath, Peter F.; Holota, Wolfgang; Schulte, Hans Reiner; Weise, Dennis

    2006-11-01

    As part of the current LISA Mission Formulation Study, and based on prior internal investigations, Astrium Germany has defined and preliminary assessed novel payload architectures, potentially reducing overall complexity and improving budgets and costs. A promising concept is characterized by a single active inertial sensor attached to a single optical bench and serving both adjacent interferometer arms via two rigidly connected off-axis telescopes. The in-plane triangular constellation ``breathing angle'' compensation is accomplished by common telescope in-field of view pointing actuation of the transmit/received beams line of sight. A dedicated actuation mechanism located on the optical bench is required in addition to the on bench actuators for differential pointing of the transmit and receive direction perpendicular to the constellation plane. Both actuators operate in a sinusoidal yearly period. A technical challenge is the actuation mechanism pointing jitter and the monitoring and calibration of the laser phase walk which occurs while changing the optical path inside the optical assembly during re-pointing. Calibration or monitoring of instrument internal phase effects e.g. by a laser metrology truss derived from the existing interferometry is required. The architecture exploits in full the two-step interferometry (strap down) concept, separating functionally inter spacecraft and intra-spacecraft interferometry (reference mass laser metrology degrees of freedom sensing). The single test mass is maintained as cubic, but in free-fall in the lateral degrees of freedom within the constellation plane. Also the option of a completely free spherical test mass with full laser interferometer readout has been conceptually investigated. The spherical test mass would rotate slowly, and would be allowed to tumble. Imperfections in roundness and density would be calibrated from differential wave front sensing in a tetrahedral arrangement, supported by added attitude

  20. Confusion noise from LISA capture sources

    International Nuclear Information System (INIS)

    Barack, Leor; Cutler, Curt

    2004-01-01

    Captures of compact objects (COs) by massive black holes (MBHs) in galactic nuclei will be an important source for LISA, the proposed space-based gravitational wave (GW) detector. However, a large fraction of captures will not be individually resolvable - either because they are too distant, have unfavorable orientation, or have too many years to go before final plunge - and so will constitute a source of 'confusion noise', obscuring other types of sources. In this paper we estimate the shape and overall magnitude of the GW background energy spectrum generated by CO captures. This energy spectrum immediately translates to a spectral density S h capt (f) for the amplitude of capture-generated GWs registered by LISA. The overall magnitude of S h capt (f) is linear in the CO capture rates, which are rather uncertain; therefore we present results for a plausible range of rates. S h capt (f) includes the contributions from both resolvable and unresolvable captures, and thus represents an upper limit on the confusion noise level. We then estimate what fraction of S h capt (f) is due to unresolvable sources and hence constitutes confusion noise. We find that almost all of the contribution to S h capt (f) coming from white dwarf and neutron star captures, and at least ∼30% of the contribution from black hole captures, is from sources that cannot be individually resolved. Nevertheless, we show that the impact of capture confusion noise on the total LISA noise curve ranges from insignificant to modest, depending on the rates. Capture rates at the high end of estimated ranges would raise LISA's overall (effective) noise level [fS h eff (f)] 1/2 by at most a factor ∼2 in the frequency range 1-10 mHz, where LISA is most sensitive. While this slightly elevated noise level would somewhat decrease LISA's sensitivity to other classes of sources, we argue that, overall, this would be a pleasant problem for LISA to have: It would also imply that detection rates for CO captures

  1. Free-flight experiments in LISA Pathfinder

    International Nuclear Information System (INIS)

    Armano, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Baird, J; Bortoluzzi, D; Brandt, N; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Cutler, C; Dunbar, N; Ferraioli, L

    2015-01-01

    The LISA Pathfinder mission will demonstrate the technology of drag-free test masses for use as inertial references in future space-based gravitational wave detectors. To accomplish this, the Pathfinder spacecraft will perform drag-free flight about a test mass while measuring the acceleration of this primary test mass relative to a second reference test mass. Because the reference test mass is contained within the same spacecraft, it is necessary to apply forces on it to maintain its position and attitude relative to the spacecraft. These forces are a potential source of acceleration noise in the LISA Pathfinder system that are not present in the full LISA configuration. While LISA Pathfinder has been designed to meet it's primary mission requirements in the presence of this noise, recent estimates suggest that the on-orbit performance may be limited by this ‘suspension noise’. The drift-mode or free-flight experiments provide an opportunity to mitigate this noise source and further characterize the underlying disturbances that are of interest to the designers of LISA-like instruments. This article provides a high-level overview of these experiments and the methods under development to analyze the resulting data. (paper)

  2. Hipertrofia muscular em desenervaçao: relato de dois casos com estudo histoquímico e histométrico dos músculos normais e hipertróficos

    Directory of Open Access Journals (Sweden)

    Lineu Cesar Werneck

    1984-09-01

    Full Text Available Relato de dois pacientes do sexo masculino, com 31 e 24 anos de idade, que apresentavam hipertrofia muscular localizada no membro inferior esquerdo, cuja investigação revelou sinais de desenervação pela eletromiografia. Foram submetidos a biópsia muscular no lado normal e no hipertrófico, processadas por histoquímica. Posteriormente, foi calculado o diâmetro médio das fibras, percentagem de tipo específico de fibras, fatores de atrofia e hipertrofia, bem como foi feita análise histográfica dos tipos de fibras. Foi encontrada grande quantidade de fibras hipertróficas, raras fibras atróficas e, na diferenciação histoquímica, um dos pacientes apresentava hipertrofia de fibras do tipo II e o outro hipertrofia tanto de fibras do tipo I, como II. Pelo cálculo dos fatores de atrofia e hipertrofia, existia predominantemente hipertrofia de fibras do tipo II em ambos os quadriceps nos dois casos e hipertrofia de fibras do tipol no caso 2. São discutidos os fatores causadores de hipertrofia em desenervação sendo que no caso 1 a etiologia foi possivelmente radiculite de SI e, no caso 2, secundária a doença do neurônio motor inferior.

  3. Data analysis for the LISA Technology Package

    International Nuclear Information System (INIS)

    Hewitson, M; Danzmann, K; Diepholz, I; GarcIa, A; Armano, M; Fauste, J; Benedetti, M; Bogenstahl, J; Bortoluzzi, D; Bosetti, P; Cristofolini, I; Brandt, N; Cavalleri, A; Ciani, G; Dolesi, R; Ferraioli, L; Cruise, M; Fertin, D; GarcIa, C; Fichter, W

    2009-01-01

    The LISA Technology Package (LTP) on board the LISA Pathfinder mission aims to demonstrate some key concepts for LISA which cannot be tested on ground. The mission consists of a series of preplanned experimental runs. The data analysis for each experiment must be designed in advance of the mission. During the mission, the analysis must be carried out promptly so that the results can be fed forward into subsequent experiments. As such a robust and flexible data analysis environment needs to be put in place. Since this software is used during mission operations and effects the mission timeline, it must be very robust and tested to a high degree. This paper presents the requirements, design and implementation of the data analysis environment (LTPDA) that will be used for analysing the data from LTP. The use of the analysis software to perform mock data challenges (MDC) is also discussed, and some highlights from the first MDC are presented.

  4. Data analysis for the LISA Technology Package

    Energy Technology Data Exchange (ETDEWEB)

    Hewitson, M; Danzmann, K; Diepholz, I; GarcIa, A [Albert-Einstein-Institut, Max-Planck-Institut fuer Gravitationsphysik und Universitaet Hannover, 30167 Hannover (Germany); Armano, M; Fauste, J [European Space Agency, ESAC, Villanueva de la Canada, 28692 Madrid (Spain); Benedetti, M [Dipartimento di Ingegneria dei Materiali e Tecnologie Industriali, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Bogenstahl, J [Department of Physics and Astronomy, University of Glasgow, Glasgow (United Kingdom); Bortoluzzi, D; Bosetti, P; Cristofolini, I [Dipartimento di Ingegneria Meccanica e Strutturale, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Brandt, N [Astrium GmbH, 88039 Friedrichshafen (Germany); Cavalleri, A; Ciani, G; Dolesi, R; Ferraioli, L [Dipartimento di Fisica, Universita di Trento and INFN, Gruppo Collegato di Trento, 38050 Povo, Trento (Italy); Cruise, M [Department of Physics and Astronomy, University of Birmingham, Birmingham (United Kingdom); Fertin, D; GarcIa, C [European Space Agency, ESTEC, 2200 AG Noordwijk (Netherlands); Fichter, W, E-mail: martin.hewitson@aei.mpg.d [Institut fuer Flugmechanik und Flugregelung, 70569 Stuttgart (Germany)

    2009-05-07

    The LISA Technology Package (LTP) on board the LISA Pathfinder mission aims to demonstrate some key concepts for LISA which cannot be tested on ground. The mission consists of a series of preplanned experimental runs. The data analysis for each experiment must be designed in advance of the mission. During the mission, the analysis must be carried out promptly so that the results can be fed forward into subsequent experiments. As such a robust and flexible data analysis environment needs to be put in place. Since this software is used during mission operations and effects the mission timeline, it must be very robust and tested to a high degree. This paper presents the requirements, design and implementation of the data analysis environment (LTPDA) that will be used for analysing the data from LTP. The use of the analysis software to perform mock data challenges (MDC) is also discussed, and some highlights from the first MDC are presented.

  5. Reconstructing the dark sector interaction with LISA

    Energy Technology Data Exchange (ETDEWEB)

    Cai, Rong-Gen; Yang, Tao [CAS Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, P.O. Box 2735, Beijing 100190 (China); Tamanini, Nicola, E-mail: cairg@itp.ac.cn, E-mail: nicola.tamanini@cea.fr, E-mail: yangtao@itp.ac.cn [Institut de Physique Théorique, CEA-Saclay, CNRS UMR 3681, Université Paris-Saclay, F-91191 Gif-sur-Yvette (France)

    2017-05-01

    We perform a forecast analysis of the ability of the LISA space-based interferometer to reconstruct the dark sector interaction using gravitational wave standard sirens at high redshift. We employ Gaussian process methods to reconstruct the distance-redshift relation in a model independent way. We adopt simulated catalogues of standard sirens given by merging massive black hole binaries visible by LISA, with an electromagnetic counterpart detectable by future telescopes. The catalogues are based on three different astrophysical scenarios for the evolution of massive black hole mergers based on the semi-analytic model of E. Barausse, Mon. Not. Roy. Astron. Soc. 423 (2012) 2533. We first use these standard siren datasets to assess the potential of LISA in reconstructing a possible interaction between vacuum dark energy and dark matter. Then we combine the LISA cosmological data with supernovae data simulated for the Dark Energy Survey. We consider two scenarios distinguished by the time duration of the LISA mission: 5 and 10 years. Using only LISA standard siren data, the dark sector interaction can be well reconstructed from redshift z ∼1 to z ∼3 (for a 5 years mission) and z ∼1 up to z ∼5 (for a 10 years mission), though the reconstruction is inefficient at lower redshift. When combined with the DES datasets, the interaction is well reconstructed in the whole redshift region from 0 z ∼ to z ∼3 (5 yr) and z ∼0 to z ∼5 (10 yr), respectively. Massive black hole binary standard sirens can thus be used to constrain the dark sector interaction at redshift ranges not reachable by usual supernovae datasets which probe only the z ∼< 1.5 range. Gravitational wave standard sirens will not only constitute a complementary and alternative way, with respect to familiar electromagnetic observations, to probe the cosmic expansion, but will also provide new tests to constrain possible deviations from the standard ΛCDM dynamics, especially at high redshift.

  6. LISA Mission and System architectures and performances

    International Nuclear Information System (INIS)

    Gath, Peter F; Weise, Dennis; Schulte, Hans-Reiner; Johann, Ulrich

    2009-01-01

    In the context of the LISA Mission Formulation Study, the LISA System was studied in detail and a new baseline architecture for the whole mission was established. This new baseline is the result of trade-offs on both, mission and system level. The paper gives an overview of the different mission scenarios and configurations that were studied in connection with their corresponding advantages and disadvantages as well as performance estimates. Differences in the required technologies and their influence on the overall performance budgets are highlighted for all configurations. For the selected baseline concept, a more detailed description of the configuration is given and open issues in the technologies involved are discussed.

  7. LISA Mission and System architectures and performances

    Energy Technology Data Exchange (ETDEWEB)

    Gath, Peter F; Weise, Dennis; Schulte, Hans-Reiner; Johann, Ulrich, E-mail: peter.gath@astrium.eads.ne [Astrium GmbH Satellites, 88039 Friedrichshafen (Germany)

    2009-03-01

    In the context of the LISA Mission Formulation Study, the LISA System was studied in detail and a new baseline architecture for the whole mission was established. This new baseline is the result of trade-offs on both, mission and system level. The paper gives an overview of the different mission scenarios and configurations that were studied in connection with their corresponding advantages and disadvantages as well as performance estimates. Differences in the required technologies and their influence on the overall performance budgets are highlighted for all configurations. For the selected baseline concept, a more detailed description of the configuration is given and open issues in the technologies involved are discussed.

  8. Galactic binaries with eLISA

    OpenAIRE

    Nelemans, G.

    2013-01-01

    I review what eLISA will see from Galactic binaries -- double stars with orbital periods less than a few hours and white dwarf (or neutron star/black hole) components. I discuss the currently known binaries that are guaranteed (or verification) sources and explain why the expected total number of eLISA Galactic binaries is several thousand, even though there are large uncertainties in our knowledge of this population, in particular that of the interacting AM CVn systems. I very briefly sketch...

  9. Morfologia e morfometria dos tipos de fibras do músculo reto abdominal de cadelas (Canis familiaris durante a gestação

    Directory of Open Access Journals (Sweden)

    Maila Karina Mattos de Brito

    2007-08-01

    Full Text Available Neste trabalho foram avaliadas as alterações morfológicas e o grau de hipertrofia das fibras de contração lentas (tipo I e rápidas (tipo II do músculo reto abdominal de cadelas adultas nas fases: pré-gestacional, 30 e 60 dias de gestação e 30 dias pós-parto (pp. Em todas essas fases, sob anestesia, foram removidas biópsias musculares, as quais foram congeladas. Cortes histológicos foram obtidos em um micrótomo e corados com hematoxilina e eosina (HE para a avaliação da morfologia. Outros cortes foram submetidos à ATPase miofibrilar (m-ATPase, após pré-incubação em meio alcalino (pH = 10,4 e em meio ácido (pH = 4,4, visando à identificação das fibras tipo I e II. Nas cadelas virgens, o tecido muscular revelou-se constituído por fibras com diferentes diâmetros, com contornos poligonais, tendo um ou mais núcleos periféricos. Estas características foram similares nos animais com 30 dias de gestação. Aos 60 dias, ao lado de fibras com aparência normal, observaram-se fibras com contornos mais polimórficos e outras fibras de diâmetros muito pequenos. Aos 30 dias pp, as características do tecido foram similares às dos animais em fase pré-gestacional. Em todas as fases estudadas, os diâmetros fibras tipo II foram maiores do que as do tipo I. Aos 30 dias observou-se a redução significativa dos diâmetros de ambos os tipos de fibras e aumento significativo aos 60 dias de gestação. Durante a gestação, o estímulo crônico, representado pela expansão da parede abdominal, promoveu alterações da morfologia e morfometria das fibras.

  10. Mona Lisa kuulsa naeratuse saladus leidis lahenduse / Johannes Saar

    Index Scriptorium Estoniae

    Saar, Johannes, 1965-

    2004-01-01

    Firenze kunstiajalooõpetaja Giuseppe Pallanti jõudis 25-aastase arhiivitöö tulemusena järeldusele, et Leonardo da Vinci Mona Lisa modelliks on siidikaupmehe Francesco del Giocondo abikaasa Lisa Gerardini

  11. The Mona Lisa of modern science.

    Science.gov (United States)

    Kemp, Martin

    2003-01-23

    No molecule in the history of science has reached the iconic status of the double helix of DNA. Its image has been imprinted on all aspects of society, from science, art, music, cinema, architecture and advertising. This review of the Mona Lisa of science examines the evolution of its form at the hands of both science and art.

  12. Myotonic Muscular Dystrophy

    Science.gov (United States)

    ... Marie-Tooth Disease (CMT) Congenital Muscular Dystrophy (CMD) Duchenne Muscular Dystrophy (DMD) Emery-Dreifuss Muscular Dystrophy Endocrine Myopathies Metabolic Diseases of Muscle Mitochondrial Myopathies (MM) Myotonic Dystrophy (DM) Spinal-Bulbar ...

  13. A noise simulator for eLISA: Migrating LISA Pathfinder knowledge to the eLISA mission

    OpenAIRE

    Armano, M.; Audley, H.; Auger, G.; Baird, J.; Binetruy, P.; Born, Michael; Bortoluzzi, D.; Brandt, N.; Bursi, A.; Caleno, M.; Cavalleri, A.; Cesarini, A.; Cruise, M.; Danzmann, Karsten; Diepholz, I.

    2015-01-01

    We present a new technical simulator for the eLISA mission, based on state space modeling techniques and developed in MATLAB. This simulator computes the coordinate and velocity over time of each body involved in the constellation, i.e. the spacecraft and its test masses, taking into account the different disturbances and actuations. This allows studying the contribution of instrumental noises and system imperfections on the residual acceleration applied on the TMs, the latter reflecting the ...

  14. Time-delay interferometry for LISA

    International Nuclear Information System (INIS)

    Tinto, Massimo; Estabrook, F.B.; Armstrong, J.W.

    2002-01-01

    LISA (Laser Interferometer Space Antenna) is a mission to detect and study low-frequency cosmic gravitational radiation through its influence on the phases or frequencies of laser beams exchanged between three remote spacecraft. We previously showed how, with lasers of identical frequencies on stationary spacecraft, the measurement of twelve time series of Doppler shifts could be combined to cancel exactly the phase noise of the lasers and the Doppler fluctuations due to noninertial motions of the six optical benches, while preserving gravitational wave signals. Here we generalize those results on gravitational wave detection with time-delay interferometry to the expected LISA instrument. The six lasers have different center frequencies (in the nominal LISA configuration these center frequencies may well differ by several hundred megahertz) and the distances between spacecraft pairs will change with time (these slowly varying orbital Doppler shifts are expected to be up to tens of megahertz). We develop time-delay data combinations which, as previously, preserve gravitational waves and exactly cancel the leading noise source (phase fluctuations of the six lasers); these data combinations then imply transfer functions for the remaining system noises. Using these, we plot frequency and phase power spectra for modeled system noises in the unequal Michelson combination X and the symmetric Sagnac combination ζ. Although optical bench noise can no longer be cancelled exactly, with the current LISA specifications it is suppressed to negligible levels. It is known that the presently anticipated laser center frequency differences and the orbital Doppler drifts introduce another source of phase noise, arising from the onboard oscillators required to track the photodetector fringes. For the presently planned mission, our analysis indeed demonstrates that noise from current-generation ultrastable oscillators would, if uncorrected, dominate the LISA noise budget. To meet the

  15. LISA Sources in Milky Way Globular Clusters

    Science.gov (United States)

    Kremer, Kyle; Chatterjee, Sourav; Breivik, Katelyn; Rodriguez, Carl L.; Larson, Shane L.; Rasio, Frederic A.

    2018-05-01

    We explore the formation of double-compact-object binaries in Milky Way (MW) globular clusters (GCs) that may be detectable by the Laser Interferometer Space Antenna (LISA). We use a set of 137 fully evolved GC models that, overall, effectively match the properties of the observed GCs in the MW. We estimate that, in total, the MW GCs contain ˜21 sources that will be detectable by LISA. These detectable sources contain all combinations of black hole (BH), neutron star, and white dwarf components. We predict ˜7 of these sources will be BH-BH binaries. Furthermore, we show that some of these BH-BH binaries can have signal-to-noise ratios large enough to be detectable at the distance of the Andromeda galaxy or even the Virgo cluster.

  16. Weak-light phase locking for LISA

    International Nuclear Information System (INIS)

    McNamara, Paul W

    2005-01-01

    The long armlengths of the LISA interferometer, and the finite aperture of the telescope, lead to an optical power attenuation of ∼10 -10 of the transmitted to received light. Simple reflection at the end of the arm is therefore not an optimum interferometric design. Instead, a local laser is offset phase locked to the weak incoming beam, transferring the phase information of the incoming to the outgoing light. This paper reports on an experiment to characterize a weak-light phase-locking scheme suitable for LISA in which a diode-pumped, Nd:YAG, non-planar ring oscillator (NPRO) is offset phase locked to a low-power (13 pW) frequency stabilized master NPRO. Preliminary results of the relative phase noise of the slave laser shows shot noise limited performance above 0.4 Hz. Excess noise is observed at lower frequencies, most probably due to thermal effects in the optical arrangement and phase-sensing electronics

  17. Data Analysis for the LISA Pathfinder Mission

    Science.gov (United States)

    Thorpe, James Ira

    2009-01-01

    The LTP (LISA Technology Package) is the core part of the Laser Interferometer Space Antenna (LISA) Pathfinder mission. The main goal of the mission is to study the sources of any disturbances that perturb the motion of the freely-falling test masses from their geodesic trajectories as well as 10 test various technologies needed for LISA. The LTP experiment is designed as a sequence of experimental runs in which the performance of the instrument is studied and characterized under different operating conditions. In order to best optimize subsequent experimental runs, each run must be promptly analysed to ensure that the following ones make best use of the available knowledge of the instrument ' In order to do this, all analyses must be designed and tested in advance of the mission and have sufficient built-in flexibility to account for unexpected results or behaviour. To support this activity, a robust and flexible data analysis software package is also required. This poster presents two of the main components that make up the data analysis effort: the data analysis software and the mock-data challenges used to validate analysis procedures and experiment designs.

  18. LISA and LISA PathFinder, the endeavour to detect low frequency GWs

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, H [Blackett Laboratory, Imperial College London, Prince Consort Road, London SW7 2BW (United Kingdom); Boatella, C [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Chmeissani, M [Institut de Fisica d' Altes Energies (IFAE), Edifici C, Universitat Autonoma de Barcelona, 08193 Bellaterra (Barcelona) (Spain); Conchillo, A [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Garcia-Berro, E [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Grimani, C [Universita degli Studi di Urbino, and INFN Florence, Istituto di Fisica, Via Santa Chiara 27, 61029 Urbino (Italy); Hajdas, W [Department of Particles and Matter, Paul Scherrer Institut, ODRA 120, 5232 Villigen (Switzerland); Lobo, A [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Martinez, L [AtIpic, Parc Tecnologic del Valles, 08290 Cerdanyola del Valles, Barcelona (Spain); Nofrarias, M [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Ortega, J A [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Puigdengoles, C [Institut de Fisica d' Altes Energies (IFAE), Edifici C, Universitat Autonoma de Barcelona, 08193 Bellaterra (Barcelona) (Spain); Ramos-Castro, J [Departament d' Enginyeria Electronica, UPC, Campus Nord, Edif. C4, Jordi Girona 1-3, 08034 Barcelona (Spain); Sanjuan, J [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Wass, P [Blackett Laboratory, Imperial College London, Prince Consort Road, London SW7 2BW (United Kingdom); Xirgu, X [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain)

    2007-05-15

    This is a review about LISA and its technology demonstrator, LISAPathFinder. We first describe the conceptual problems which need to be overcome in order to set up a working interferometric detector of low frequency Gravitational Waves (GW), then summarise the solutions to them as currently conceived by the LISA mission team. This will show that some of these solutions require new technological abilities which are still under development, and which need proper test before being fully implemented. LISAPathFinder (LPF) is the the testbed for such technologies. The final part of the paper will address the ideas and concepts behind the PathFinder as well as their impact on LISA.

  19. LISA and LISA PathFinder, the endeavour to detect low frequency GWs

    International Nuclear Information System (INIS)

    Araujo, H; Boatella, C; Chmeissani, M; Conchillo, A; Garcia-Berro, E; Grimani, C; Hajdas, W; Lobo, A; Martinez, L; Nofrarias, M; Ortega, J A; Puigdengoles, C; Ramos-Castro, J; Sanjuan, J; Wass, P; Xirgu, X

    2007-01-01

    This is a review about LISA and its technology demonstrator, LISAPathFinder. We first describe the conceptual problems which need to be overcome in order to set up a working interferometric detector of low frequency Gravitational Waves (GW), then summarise the solutions to them as currently conceived by the LISA mission team. This will show that some of these solutions require new technological abilities which are still under development, and which need proper test before being fully implemented. LISAPathFinder (LPF) is the the testbed for such technologies. The final part of the paper will address the ideas and concepts behind the PathFinder as well as their impact on LISA

  20. Ground-based self-gravity tests for LISA Pathfinder and LISA

    International Nuclear Information System (INIS)

    Trenkel, C; Warren, C; Wealthy, D

    2009-01-01

    Gravitational coupling between the free-falling test masses and the surrounding spacecraft is one of the dominant noise sources for both LISA Pathfinder and LISA. At present, there are no plans to verify any of the self-gravity requirements by test, on the ground. Here, we explore the possibilities of conducting such tests, using a customised torsion balance. We discuss the main sources of systematic and statistical uncertainty present in such a set-up. Our preliminary assessment indicates that the sensitivity is sufficient to carry out meaningful self-gravity tests.

  1. Data analysis and source modelling for LISA

    International Nuclear Information System (INIS)

    Shang, Yu

    2014-01-01

    The gravitational waves are one of the most important predictions in general relativity. Besides of the directly proof of the existence of GWs, there are already several ground based detectors (such as LIGO, GEO, etc) and the planed future space mission (such as: LISA) which are aim to detect the GWs directly. GW contain a large amount of information of its source, extracting these information can help us dig out the physical property of the source, even open a new window for understanding the Universe. Hence, GW data analysis will be a challenging task in seeking the GWs. In this thesis, I present two works about the data analysis for LISA. In the first work, we introduce an extended multimodal genetic algorithm which utilizes the properties of the signal and the detector response function to analyze the data from the third round of mock LISA data challenge. We have found all five sources present in the data and recovered the coalescence time, chirp mass, mass ratio and sky location with reasonable accuracy. As for the orbital angular momentum and two spins of the Black Holes, we have found a large number of widely separated modes in the parameter space with similar maximum likelihood values. The performance of this method is comparable, if not better, to already existing algorithms. In the second work, we introduce an new phenomenological waveform model for the extreme mass ratio inspiral system. This waveform consists of a set of harmonics with constant amplitude and slowly evolving phase which we decompose in a Taylor series. We use these phenomenological templates to detect the signal in the simulated data, and then, assuming a particular EMRI model, estimate the physical parameters of the binary with high precision. The results show that our phenomenological waveform is very feasible in the data analysis of EMRI signal.

  2. Performance of arm locking in LISA

    International Nuclear Information System (INIS)

    McKenzie, Kirk; Spero, Robert E.; Shaddock, Daniel A.

    2009-01-01

    For the Laser Interferometer Space Antenna (LISA) to reach its design sensitivity, the coupling of the free-running laser frequency noise to the signal readout must be reduced by more than 14 orders of magnitude. One technique employed to reduce the laser frequency noise will be arm locking, where the laser frequency is locked to the LISA arm length. In this paper we detail an implementation of arm locking. We investigate orbital effects (changing arm lengths and Doppler frequencies), the impact of errors in the Doppler knowledge that can cause pulling of the laser frequency, and the noise limit of arm locking. Laser frequency pulling is examined in two regimes: at lock acquisition and in steady state. The noise performance of arm locking is calculated with the inclusion of the dominant expected noise sources: ultrastable oscillator (clock) noise, spacecraft motion, and shot noise. We find that clock noise and spacecraft motion limit the performance of dual arm locking in the LISA science band. Studying these issues reveals that although dual arm locking [A. Sutton and D. A. Shaddock, Phys. Rev. D 78, 082001 (2008)] has advantages over single (or common) arm locking in terms of allowing high gain, it has disadvantages in both laser frequency pulling and noise performance. We address this by proposing a modification to the dual arm-locking sensor, a hybrid of common and dual arm-locking sensors. This modified dual arm-locking sensor has the laser frequency pulling characteristics and low-frequency noise coupling of common arm locking, but retains the control system advantages of dual arm locking. We present a detailed design of an arm-locking controller and perform an analysis of the expected performance when used with and without laser prestabilization. We observe that the sensor phase changes beneficially near unity-gain frequencies of the arm-locking controller, allowing a factor of 10 more gain than previously believed, without degrading stability. With a time

  3. The LISA Pathfinder DMU and Radiation Monitor

    Energy Technology Data Exchange (ETDEWEB)

    Canizares, P; Conchillo, A; Gesa, L; Lloro, I; Lobo, A; Mateos, I; Sopuerta, Carlos F [Institut de Ciencies de l' Espai, CSIC, Facultat de Ciencies, Torre C5 parell, 08193 Bellaterra (Spain); Chmeissani, M [Institut de Fisica d' Altes Energies (IFAE), Edifici CN, UAB Campus, 08193 Bellaterra (Spain); Diaz-Aguilo, M; GarcIa-Berro, E; Gibert, F [Institut d' Estudis Espacials de Catalunya (IEEC), Edifici Nexus, Gran Capita 2-4, 08034 Barcelona (Spain); Grimani, C [Universita degli Studi di Urbino, MFI Department, Via Santa Chiara 27, 61029 Urbino, and INFN Florence (Italy); Nofrarias, M [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut), Callinstrasse 38, D-30167 Hannover (Germany); Ramos-Castro, J [Departament d' Enginyeria Electronica, UPC, Campus Nord, Edifici C4, Jordi Girona 1-3, 08034 Barcelona (Spain); Sanjuan, J [Department of Physics, University of Florida, NPB-22258 PO Box 118 440, Gainesville, FL 32611-8440 (United States); Araujo, H M; Wass, P, E-mail: lobo@ieec.fcr.es [High Energy Physics Blackett Laboratory, Prince Consort Road, Imperial College London, London SW7 2BW (United Kingdom)

    2011-05-07

    The LISA Pathfinder DMU (Data Management Unit) flight model was formally accepted by ESA and ASD on 11 February 2010, after all hardware and software tests had been successfully completed. The diagnostics items are scheduled to be delivered by the end of 2010. In this paper, we review the requirements and performance of this instrumentation, specially focusing on the Radiation Monitor and the DMU, as well as the status of their programmed use during mission operations, on which work is ongoing at the time of writing.

  4. LISA Beyond Einstein: From the Big Bang to Black Holes. LISA Technology Development at GSFC

    Science.gov (United States)

    Thorpe, James Ira

    2008-01-01

    This viewgraph presentation reviews the work that has been ongoing at the Goddard Space Flight Center (GSFC) in the development of the technology to be used in the Laser Interferometer Space Antenna (LISA) spacecrafts. The prime focus of LISA technology development efforts at NASA/GSFC has been in LISA interferometry. Specifically efforts have been made in the area of laser frequency noise mitigation. Laser frequency noise is addressed through a combination of stabilization and common-mode rejection. Current plans call for two stages of stabilization, pre-stabilization to a local frequency reference and further stabilization using the constellation as a frequency reference. In order for these techniques to be used simultaneously, the pre-stabilization step must provide an adjustable frequency offset. This presentation reports on a modification to the standard modulation/demodulation technique used to stabilize to optical cavities that generates a frequency-tunable reference from a fixed length cavity. This technique requires no modifications to the cavity itself and only minor modifications to the components. The measured noise performance and dynamic range of the laboratory prototype meet the LISA requirements.

  5. Lipoma con patrón infiltrativo muscular

    OpenAIRE

    Vergara Pages, Julio AJ; Ferrer Lozano, Yovanny; Rodríguez Reyna, Juan C.; Medina González, Maria E

    2006-01-01

    Los lipomas pueden crecer hasta alcanzar un gran tamaño y se clasifican en dos tipos: cutáneo o superficial, cuando se localizan encapsulados en los tejidos blandos superficiales; y profundo o subfascial, cuando su origen es poco delimitado o difuso y presentan estructuras profundas intraóseas, intermusculares e intramusculares. Esta última es poco usual, su localización puede pasar por desapercibida y toma un patrón de crecimiento infiltrativo a través de las fibras musculares estriadas, lo ...

  6. Optical testbed for the LISA phasemeter

    International Nuclear Information System (INIS)

    Schwarze, T S; Fernández Barranco, G; Penkert, D; Gerberding, O; Heinzel, G; Danzmann, K

    2016-01-01

    The planned spaceborne gravitational wave detector LISA will allow the detection of gravitational waves at frequencies between 0.1 mHz and 1 Hz. A breadboard model for the metrology system aka the phasemeter was developed in the scope of an ESA technology development project by a collaboration between the Albert Einstein Institute, the Technical University of Denmark and the Danish industry partner Axcon Aps. It in particular provides the electronic readout of the main interferometer phases besides auxiliary functions. These include clock noise transfer, ADC pilot tone correction, inter-satellite ranging and data transfer. Besides in LISA, the phasemeter can also be applied in future satellite geodesy missions. Here we show the planning and advances in the implementation of an optical testbed for the full metrology chain. It is based on an ultra-stable hexagonal optical bench. This bench allows the generation of three unequal heterodyne beatnotes with a zero phase combination, thus providing the possibility to probe the phase readout for non-linearities in an optical three signal test. Additionally, the utilization of three independent phasemeters will allow the testing of the auxiliary functions. Once working, components can individually be replaced with flight-qualified hardware in this setup. (paper)

  7. Optical testbed for the LISA phasemeter

    Science.gov (United States)

    Schwarze, T. S.; Fernández Barranco, G.; Penkert, D.; Gerberding, O.; Heinzel, G.; Danzmann, K.

    2016-05-01

    The planned spaceborne gravitational wave detector LISA will allow the detection of gravitational waves at frequencies between 0.1 mHz and 1 Hz. A breadboard model for the metrology system aka the phasemeter was developed in the scope of an ESA technology development project by a collaboration between the Albert Einstein Institute, the Technical University of Denmark and the Danish industry partner Axcon Aps. It in particular provides the electronic readout of the main interferometer phases besides auxiliary functions. These include clock noise transfer, ADC pilot tone correction, inter-satellite ranging and data transfer. Besides in LISA, the phasemeter can also be applied in future satellite geodesy missions. Here we show the planning and advances in the implementation of an optical testbed for the full metrology chain. It is based on an ultra-stable hexagonal optical bench. This bench allows the generation of three unequal heterodyne beatnotes with a zero phase combination, thus providing the possibility to probe the phase readout for non-linearities in an optical three signal test. Additionally, the utilization of three independent phasemeters will allow the testing of the auxiliary functions. Once working, components can individually be replaced with flight-qualified hardware in this setup.

  8. Detection of Micrometeoroids with LISA Pathfinder

    Science.gov (United States)

    Thorpe, Ira; Littenberg, Tyson; Janchez, Diego; Baker, John; The LISA Pathfinder Team Team

    2017-01-01

    The LISA Pathfinder mission (LPF), a joint ESA/NASA technology demonstration mission currently operating at the Sun-Earth L1 point, contains the most precise accelerometry system ever flown. Analysis suggests that LPF should have sufficient sensitivity to detect impacts of small micrometeoroids and dust through their transfer of momentum to the spacecraft. Moreover, LPF's ability to fully resolve both the linear and angular momentum transfer in three dimensions allows a magnitude, direction, and location to be estimated for each impact. We present preliminary results from a systematic search of the LISA Pathfinder data for such impacts and discuss the prospects for using these and future results to inform models of the formation and evolution of dust populations in the inner solar system. These models have wide applicability to both pure and applied space science, ranging from the physics of planet formation and dynamics of minor Solar System bodies to estimates of the micrometeorite hazard for future spacecraft. 2017 NASA Science Innovation Fund.

  9. LISA as a dark energy probe

    International Nuclear Information System (INIS)

    Arun, K G; Mishra, Chandra Kant; Iyer, B R; Sinha, Siddhartha; Van Den Broeck, Chris; Sathyaprakash, B S

    2009-01-01

    Recently, it has been shown that the inclusion of higher signal harmonics in the inspiral signals of binary supermassive black holes (SMBH) leads to dramatic improvements in the parameter estimation with Laser Interferometer Space Antenna (LISA). In particular, the angular resolution becomes good enough to identify the host galaxy or galaxy cluster, in which case the redshift can be determined by electromagnetic means. The gravitational wave signal also provides the luminosity distance with high accuracy, and the relationship between this and the redshift depends sensitively on the cosmological parameters, such as the equation-of-state parameter w = p DE /ρ DE of dark energy. Using binary SMBH events at z < 1 with appropriate masses and orientations, one would be able to constrain w to within a few per cent. We show that, if the measured sky location is folded into the error analysis, the uncertainty on w goes down by an additional factor of 2-3, leaving weak lensing as the only limiting factor in using LISA as a dark energy probe.

  10. Immunohistochemical alterations of dystrophin in congenital muscular dystrophy Alterações imuno-hístoquímicas da distrofina na distrofia muscular congênita

    Directory of Open Access Journals (Sweden)

    Lineu Cesar Werneck

    1995-09-01

    Full Text Available The dystrophin distribution in the plasma muscle membrane using immunohystochemistry was studied in 22 children with congenital muscular dystrophy. The dystrophin was detected by immunofluorescence in muscle biopsy through a polyclonal antibody. All the cases had patchy interruptions of the fluorescence in the plasma membrane. A large patchy interruption of the sarcolemma was found in 17 cases, small interruption in 12, and a combination of large and small patchy discontinuity in 7. Small gaps around the fiber like a rosary were found in 15 cases. The frequency of these abnormalities ranged cases from: all fibers in 5 cases, frequent in 8, occasional in 5, and rare in 4. Five cases had total absence of immunofluorescence. These results suggest that the dystrophin expression is abnormal in this group of children and that this type of abnormalities can not be differentiated from early Becker muscular dystrophy nor childhood autosomal recessive muscular dystrophy through immunohystochemistry alone.Foi estudada a distribuição da distrofina na membrana plasmática das fibras musculares em 22 crianças com distrofia muscular congênita, através de técnicas de imuno-histoquímica. A distrofina foi identificada nas biópsias musculares processadas a fresco, por técnicas de imunofluorescência utilizando anticorpos policlonais. Todos os casos tinham interrupções da imunofluorescência na membrana plasmática. Em 17 elas eram grandes, em 12 eram pequenas e em 7 eram de ambos os tipos. Fibras com interrupções pequenas e constantes, como um rosário, foram vistas em 15 casos. Essas anormalidades estavam presentes em todas as fibras em 5 casos, eram frequentes em 8, ocasionais em 5 e raras em 4. Cinco casos mostraram fibras sem distrofina. Esses dados sugerem que a expressão da distrofina é anormal nesse grupo de crianças. Essas anormalidades podem também ser encontradas em casos precoces de distrofia muscular de Becker e distrofia autoss

  11. Avaliação neuropsicológica de pacientes com distrofia muscular de Duchenne

    OpenAIRE

    Elaine Cristina Zachi

    2009-01-01

    A Distrofia Muscular de Duchenne (DMD) é provocada por mutações no gene distrofina. Este gene codifica a proteína distrofina, que exerce papel importante na manutenção da estabilidade da membrana da fibra muscular. Os objetivos do estudo consistiram em examinar o desempenho neuropsicológico de pacientes com DMD e verificar a influência de deleções downstream ao exon 45 sobre o mesmo. Foram avaliados os perfis de inteligência de 63 pacientes com DMD por meio das Escalas Wechsler de Inteligênci...

  12. Interferometry for the LISA technology package LTP: an update

    International Nuclear Information System (INIS)

    Heinzel, G; Bogenstahl, J; Braxmaier, C; Danzmann, K; Garcia, A; Guzman, F; Hough, J; Hoyland, D; Jennrich, O; Killow, C; Robertson, D; Sodnik, Z; Steier, F; Ward, H; Wand, V

    2006-01-01

    This paper gives an update on the status of the LISA technology package (LTP) which is to be launched in 2009 by ESA as a technology demonstration mission for the spaceborne gravitational wave observatory LISA. The dominant noise source in the interferometer prototype has been investigated and improved such that it is now comfortably below its budget at all frequencies

  13. Uso da Fibra de Coco em Betão

    OpenAIRE

    Gonçalves, Stephanie Assunção

    2016-01-01

    O presente trabalho tem como objetivo avaliar as resistências à compressão axial, tração por compressão diametral e tração na flexão, módulos de elasticidade estático e dinâmico do betão reforçado com fibra de coco (BRFC), tendo como referência o betão preparado sem a adição de fibra. A escolha da fibra natural decorreu da necessidade de utilizar os resíduos gerados pelo consumo do coco verde. Sendo assim, este trabalho apresenta uma breve história do betão, suas propriedades, tipos de fibras...

  14. Distrofia muscular de Emery-Dreifuss: relato de caso Emery-Dreifuss muscular dystrophy: case report

    Directory of Open Access Journals (Sweden)

    Ana Lucila Moreira Carsten

    2006-06-01

    Full Text Available A distrofia muscular de Emery-Dreifuss é uma forma de distrofia muscular freqüentemente associada a contraturas articulares e defeitos de condução cardíaca, que pode ser causada pela deficiência da proteína emerina na membrana nuclear interna das fibras musculares. Descrevemos o caso de um homem de 19 anos com diminuição de força muscular, hipotrofia nas cinturas escapular e pélvica, disfagia, contraturas articulares em cotovelos e tornozelos, apresentando história familiar compatível com herança ligada ao cromossomo X. A investigação mostrou creatinaquinase sérica elevada, eletrocardiograma com bloqueio atrioventricular de primeiro grau e bloqueio de ramo direito, eletroneuromiografia normal, biópsia muscular com alterações miopáticas e a análise por imuno-histoquímica mostrou deficiência de emerina. São discutidas as manifestações clínicas e genéticas, alterações laboratoriais e eletroneuromiográficas, bem como, a importância do estudo do padrão de herança no aconselhamento genético destas famílias.The Emery-Dreifuss muscular dystrophy is a form of muscular dystrophy that frequently presents early contractures and cardiac conduction defects, caused by emerin deficiency in the inner nuclear membrane of the muscular fibers. A 19-years-old man it presented muscle weakness and hypotrophy in the proximal upper and lower limbs, dysphagia and early contractures in elbows and ankles, with familiar history compatible with X-linked inheritance form. The investigation showed increased serum creatinekinase levels electrocardiogram had a first degree atrioventricular block and right bundle branch block normal electromyography and nerve conduction study muscle biopsy disclosed myopathic characteristics and nuclear protein immunohystochemical analysis showed deficiency of emerin. The clinical and genetics manifestations, laboratorial and electromyography changes, as well as, the study of the pattern of inheritance for

  15. Fundamentals of the LISA stable flight formation

    International Nuclear Information System (INIS)

    Dhurandhar, S V; Nayak, K Rajesh; Koshti, S; Vinet, J-Y

    2005-01-01

    The joint NASA-ESA mission, LISA, relies crucially on the stability of the three-spacecraft constellation. Each of the spacecraft is in heliocentric orbit forming a stable triangle. In this paper we explicitly show with the help of the Clohessy-Wiltshire equations that any configuration of spacecraft lying in the planes making angles of ±60 0 with the ecliptic and given suitable initial velocities within the plane, can be made stable in the sense that the inter-spacecraft distances remain constant to first order in the dimensions of the configuration compared with the distance to the Sun. Such analysis would be useful in order to carry out theoretical studies on the optical links, simulators, etc

  16. Hipertrofia muscular em desenervaçao: relato de dois casos com estudo histoquímico e histométrico dos músculos normais e hipertróficos

    OpenAIRE

    Werneck, Lineu Cesar; Caropreso, Vicente

    1984-01-01

    Relato de dois pacientes do sexo masculino, com 31 e 24 anos de idade, que apresentavam hipertrofia muscular localizada no membro inferior esquerdo, cuja investigação revelou sinais de desenervação pela eletromiografia. Foram submetidos a biópsia muscular no lado normal e no hipertrófico, processadas por histoquímica. Posteriormente, foi calculado o diâmetro médio das fibras, percentagem de tipo específico de fibras, fatores de atrofia e hipertrofia, bem como foi feita análise histográfica do...

  17. Efecto de una dieta rica en proteínas y alta en fibra más la suplementación con aminoácidos de cadena ramificada sobre el estado nutricional de pacientes con cirrosis

    Directory of Open Access Journals (Sweden)

    A. Ruiz-Margáin

    2018-01-01

    Conclusión: La suplementación con AACR más una dieta alta en proteína y fibra es una intervención segura en los pacientes con cirrosis. Ayuda al incremento de la masa muscular y no eleva los niveles de amonio o de glucosa, y tampoco se asocia con el desarrollo de encefalopatía hepática.

  18. Charge Management in LISA Pathfinder: The Continuous Discharging Experiment

    Science.gov (United States)

    Ewing, Becca Elizabeth

    2018-01-01

    Test mass charging is a significant source of excess force and force noise in LISA Pathfinder (LPF). The planned design scheme for mitigation of charge induced force noise in LISA is a continuous discharge by UV light illumination. We report on analysis of a charge management experiment on-board LPF conducted during December 2016. We discuss the measurement of test mass charging noise with and without continuous UV illumination, in addition to the dynamic response in the continuous discharge scheme. Results of the continuous discharge system will be discussed for their application to operating LISA with lower test mass charge.

  19. FIBRAS DE CARBONO NA CONSTRUÇÃO CIVIL

    Directory of Open Access Journals (Sweden)

    Nicolas Montanari

    2017-02-01

    Full Text Available Os materiais compósitos se dão pela utilização de dois, ou mais, materiais trabalhando de forma conjunta com o propósito de alcançar determinada propriedade a qual não seria possível com os mesmos isolados. A fibra de carbono com resina epóxi utilizada em reforços estruturais é um desses materiais, a grande resistência mecânica à tração e elevado módulo de elasticidade tornam a fibra de carbono adequada do ponto de vista estrutural, e com a resina epóxi atuando de modo a transferir as tensões da estrutura para serem resistidas pela fibra a caracteriza como tal. Este processo de reforço já vem se mostrando uma alternativa a métodos tradicionais, é mais rápido, simples e limpo que outros, clientes vem optando por este processo mesmo que apresente custo final mais elevado, pois quando consideradas as vantagens nele embutidas torna-se viável. Muito já se desenvolveu com a fibra de carbono no ramo da construção civil, porém ainda pode ser feito mais, descobrindo e aperfeiçoando novas técnicas construtivas compostas de materiais com fibra de carbono.

  20. Dual-Cylinder Laser Reference Cavities for LISA Project

    Data.gov (United States)

    National Aeronautics and Space Administration — "Summary: The Laser Interferometer Space Antenna (LISA) mission is under consideration by NASA and ESA as a joint mission to study gravitational wave signals from a...

  1. Gravitational Reference Sensor Front-End Electronics Simulator for LISA

    International Nuclear Information System (INIS)

    Meshksar, Neda; Ferraioli, Luigi; Mance, Davor; Zweifel, Peter; Giardini, Domenico; Ten Pierick, Jan

    2017-01-01

    At the ETH Zurich we are developing a modular simulator that provides a realistic simulation of the Front End Electronics (FEE) for LISA Gravitational Reference Sensor (GRS). It is based on the GRS FEE-simulator already implemented for LISA Pathfinder. It considers, in particular, the non-linearity and the critical details of hardware, such as the non-linear multiplicative noise caused by voltage reference instability, test mass charging and detailed actuation and sensing algorithms. We present the simulation modules, considering the above-mentioned features. Based on the ETH GRS FEE-simulator for LISA Pathfinder we aim to develop a modular simulator that provides a realistic simulation of GRS FEE for LISA. (paper)

  2. Spinal Muscular Atrophy FAQ

    Science.gov (United States)

    ... as ALS (Lou Gehrig’s Disease), cystic fibrosis and Duchenne muscular dystrophy. Approximately 1 in 50 Americans, or about 6 ... Pediatric Neuromuscular Clinical Research Network ( PNCR ) and the Muscular ... is the SMN2 gene? Muscle weakness and atrophy in SMA results from the ...

  3. LISA and its in-flight test precursor SMART-2

    International Nuclear Information System (INIS)

    Vitale, S.; Bender, P.; Brillet, A.; Buchman, S.; Cavalleri, A.; Cerdonio, M.; Cruise, M.; Cutler, C.; Danzmann, K.; Dolesi, R.; Folkner, W.; Gianolio, A.; Jafry, Y.; Hasinger, G.; Heinzel, G.; Hogan, C.; Hueller, M.; Hough, J.; Phinney, S.; Prince, T.; Richstone, D.; Robertson, D.; Rodrigues, M.; Ruediger, A.; Sandford, M.; Schilling, R.; Shoemaker, D.; Schutz, B.; Stebbins, R.; Stubbs, C.; Sumner, T.; Thorne, K.; Tinto, M.; Touboul, P.; Ward, H.; Weber, W.; Winkler, W.

    2002-01-01

    LISA will be the first space-home gravitational wave observatory. It aims to detect gravitational waves in the 0.1 mHz/1 Hz range from sources including galactic binaries, super-massive black-hole binaries, capture of objects by super-massive black-holes and stochastic background. LISA is an ESA approved Cornerstone Mission foreseen as a joint ESA-NASA endeavour to be launched in 2010-11. The principle of operation of LISA is based on laser ranging of test-masses under pure geodesic motion. Achieving pure geodesic motion at the level requested for LISA, 3x10 -15 ms -2 /√Hz at 0.1 mHz, is considered a challenging technological objective. To reduce the risk, both ESA and NASA are pursuing an in-flight test of the relevant technology. The goal of the test is to demonstrate geodetic motion within one order of magnitude from the LISA performance. ESA has given this test as the primary goal of its technology dedicated mission SMART-2 with a launch in 2006. This paper describes the basics of LISA, its key technologies, and its in-flight precursor test on SMART-2

  4. A UV LED-based Charge Management System for LISA

    Science.gov (United States)

    Conklin, John W.; Chilton, Andrew; Olatunde, Taiwo Janet; Apple, Stephen; Parry, Samantha; Ciani, Giacomo; Wass, Peter; Mueller, Guido

    2018-01-01

    The Laser Interferometer Space Antenna (LISA) will be the first space instrument to observe gravitational waves in the millihertz frequency band. LISA consists of three Sun-orbiting spacecraft that form an equilateral triangle, with each side measuring 2.5 million kilometers in length. Each spacecraft houses two free-floating test masses, which are protected from all disturbing forces so that they follow pure geodesics in spacetime. A drag-free control system commands micronewton thrusters to force the spacecraft to fly in formation with the test masses and laser interferometers measure the minute variations in the distance, or light travel time, between these free-falling test masses caused by gravitational waves. The LISA observatory, with a planned launch in the early 2030s, is led by the European Space Agency with significant contributions from NASA. Recently, NASA has initiated strategic investments in key LISA technologies that will likely become U.S. flight hardware contributions to this ground-breaking mission. One of these payload elements is the Charge Management System (CMS), which controls the electric potential of the test masses relative to their housings to reduce spurious force noise acting on the test masses to below the required level. This talk, presented by University of Florida team that leads the CMS development, will describe this vital U.S. contribution to the LISA mission in the context of the envisioned LISA payload architecture and its in-flight sensitivity to gravitational waves.

  5. Obtenção de nanocompósitos, nanodiamante sobre fibra de carbono e nanotubo de carbono sobre fibra de carbono

    OpenAIRE

    Leonardo Iusuti de Medeiros

    2009-01-01

    A proposta desta dissertação é a obtenção de dois compósitos nanoestruturados que sejam constituídos um por nanodiamante sobre fibra de carbono e, o outro, por nanotubo de carbono sobre a fibra de carbono. Em ambos os compósitos as fibras de carbono usadas são obtidas com três diferentes índices de grafitização 1000, 1500 e 2000°C. As fibras de carbono apresentam uma grande área superficial devido a sua estrutura. Quando utilizadas como substrato para crescimento de materiais nanoestruturados...

  6. Distinguishing Between Formation Channels for Binary Black Holes with LISA

    Science.gov (United States)

    Breivik, Katelyn; Rodriguez, Carl L.; Larson, Shane L.; Kalogera, Vassiliki; Rasio, Frederic A.

    2017-01-01

    The recent detections of GW150914 and GW151226 imply an abundance of stellar-mass binary-black-hole mergers in the local universe. While ground-based gravitational-wave detectors are limited to observing the final moments before a binary merges, space-based detectors, such as the Laser Interferometer Space Antenna (LISA), can observe binaries at lower orbital frequencies where such systems may still encode information about their formation histories. In particular, the orbital eccentricity and mass of binary black holes in the LISA frequency band can be used together to discriminate between binaries formed in isolation in galactic fields and those formed in dense stellar environments such as globular clusters. In this letter, we explore the orbital eccentricity and mass of binary-black-hole populations as they evolve through the LISA frequency band. Overall we find that there are two distinct populations discernible by LISA. We show that up to ~90% of binaries formed either dynamically or in isolation have eccentricities measurable by LISA. Finally, we note how measured eccentricities of low-mass binary black holes evolved in isolation could provide detailed constraints on the physics of black-hole natal kicks and common-envelope evolution.

  7. LISA Pathfinder: hardware tests and their input to the mission

    Science.gov (United States)

    Audley, Heather

    The Laser Interferometer Space Antenna (LISA) is a joint ESA-NASA mission for the first space-borne gravitational wave detector. LISA aims to detect sources in the 0.1mHz to 1Hz range, which include supermassive black holes and galactic binary stars. Core technologies required for the LISA mission, including drag-free test mass control, picometre interferometry and micro-Newton thrusters, cannot be tested on-ground. Therefore, a precursor satellite, LISA Pathfinder, has been developed as a technology demonstration mission. The preparations for the LISA Pathfinder mission have reached an exciting stage. Tests of the engineering model of the optical metrology system have recently been completed at the Albert Einstein Institute, Hannover, and flight model tests are now underway. Significantly, they represent the first complete integration and testing of the space-qualified hardware and are the first tests on system level. The results and test procedures of these campaigns will be utilised directly in the ground-based flight hardware tests, and subsequently within in-flight operations. In addition, they allow valuable testing of the data analysis methods using the MatLab based LTP data analysis toolbox. This contribution presents an overview of the test campaigns calibration, control and perfor-mance results, focusing on the implications for the Experimental Master Plan which provides the basis for the in-flight operations and procedures.

  8. Muscular Dystrophy (MD)

    Science.gov (United States)

    ... patients may need assisted ventilation to treat respiratory muscle weakness and a pacemaker for cardiac abnormalities. View Full Treatment Information Definition The muscular dystrophies (MD) are a group of more than 30 ...

  9. Facioscapulohumeral muscular dystrophy

    Science.gov (United States)

    ... There is no known cure for facioscapulohumeral muscular dystrophy. Treatments are given to control symptoms and improve quality of life. Activity is encouraged. Inactivity such as bedrest can make the muscle disease worse. Physical therapy may help maintain muscle ...

  10. Rhabdomyolysis featuring muscular dystrophies.

    Science.gov (United States)

    Lahoria, Rajat; Milone, Margherita

    2016-02-15

    Rhabdomyolysis is a potentially life threatening condition of various etiology. The association between rhabdomyolysis and muscular dystrophies is under-recognized in clinical practice. To identify muscular dystrophies presenting with rhabdomyolysis at onset or as predominant feature. We retrospectively reviewed clinical and laboratory data of patients with a genetically confirmed muscular dystrophy in whom rhabdomyolysis was the presenting or main clinical manifestation. Thirteen unrelated patients (males=6; females=7) were identified. Median age at time of rhabdomyolysis was 18 years (range, 2-47) and median duration between the first episode of rhabdomyolysis and molecular diagnosis was 2 years. Fukutin-related protein (FKRP) muscular dystrophy (n=6) was the most common diagnosis, followed by anoctaminopathy-5 (n=3), calpainopathy-3 (n=2) and dystrophinopathy (n=2). Four patients experienced recurrent rhabdomyolysis. Eight patients were asymptomatic and 3 reported myalgia and exercise intolerance prior to the rhabdomyolysis. Exercise (n=6) and fever (n=4) were common triggers; rhabdomyolysis was unprovoked in 3 patients. Twelve patients required hospitalization. Baseline CK levels were elevated in all patients (median 1200 IU/L; range, 600-3600). Muscular dystrophies can present with rhabdomyolysis; FKRP mutations are particularly frequent in causing such complication. A persistently elevated CK level in patients with rhabdomyolysis warrants consideration for underlying muscular dystrophy. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Accreting Double White Dwarf Binaries: Implications for LISA

    Energy Technology Data Exchange (ETDEWEB)

    Kremer, Kyle; Breivik, Katelyn; Larson, Shane L.; Kalogera, Vassiliki, E-mail: kremer@u.northwestern.edu, E-mail: katelyn.breivik@northwestern.edu, E-mail: vicky@northwestern.edu, E-mail: s.larson@northwestern.edu [Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA), Department of Physics and Astronomy, Northwestern University 2145 Sheridan Road, Evanston, IL 60201 (United States)

    2017-09-10

    We explore the long-term evolution of mass-transferring white dwarf (WD) binaries undergoing both direct-impact and disk accretion and explore implications of such systems to gravitational-wave (GW) astronomy. We cover a broad range of initial component masses and show that these systems, the majority of which lie within the Laser Interferometer Space Antenna ( LISA ) sensitivity range, exhibit prominent negative orbital frequency evolution (chirp) for a significant fraction of their lifetimes. Using a galactic population synthesis, we predict ∼2700 of these systems will be observable with a negative chirp of 0.1 yr{sup −2} by a space-based GW detector like LISA . We also show that detections of mass-transferring double WD systems by LISA may provide astronomers with unique ways of probing the physics governing close compact object binaries.

  12. Accreting Double White Dwarf Binaries: Implications for LISA

    Science.gov (United States)

    Kremer, Kyle; Breivik, Katelyn; Larson, Shane L.; Kalogera, Vassiliki

    2017-09-01

    We explore the long-term evolution of mass-transferring white dwarf (WD) binaries undergoing both direct-impact and disk accretion and explore implications of such systems to gravitational-wave (GW) astronomy. We cover a broad range of initial component masses and show that these systems, the majority of which lie within the Laser Interferometer Space Antenna (LISA) sensitivity range, exhibit prominent negative orbital frequency evolution (chirp) for a significant fraction of their lifetimes. Using a galactic population synthesis, we predict ˜2700 of these systems will be observable with a negative chirp of 0.1 yr-2 by a space-based GW detector like LISA. We also show that detections of mass-transferring double WD systems by LISA may provide astronomers with unique ways of probing the physics governing close compact object binaries.

  13. Bayesian statistics for the calibration of the LISA Pathfinder experiment

    International Nuclear Information System (INIS)

    Armano, M; Freschi, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Bortoluzzi, D; Brandt, N; Fitzsimons, E; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Dunbar, N; Ferraioli, L

    2015-01-01

    The main goal of LISA Pathfinder (LPF) mission is to estimate the acceleration noise models of the overall LISA Technology Package (LTP) experiment on-board. This will be of crucial importance for the future space-based Gravitational-Wave (GW) detectors, like eLISA. Here, we present the Bayesian analysis framework to process the planned system identification experiments designed for that purpose. In particular, we focus on the analysis strategies to predict the accuracy of the parameters that describe the system in all degrees of freedom. The data sets were generated during the latest operational simulations organised by the data analysis team and this work is part of the LTPDA Matlab toolbox. (paper)

  14. Accreting Double White Dwarf Binaries: Implications for LISA

    International Nuclear Information System (INIS)

    Kremer, Kyle; Breivik, Katelyn; Larson, Shane L.; Kalogera, Vassiliki

    2017-01-01

    We explore the long-term evolution of mass-transferring white dwarf (WD) binaries undergoing both direct-impact and disk accretion and explore implications of such systems to gravitational-wave (GW) astronomy. We cover a broad range of initial component masses and show that these systems, the majority of which lie within the Laser Interferometer Space Antenna ( LISA ) sensitivity range, exhibit prominent negative orbital frequency evolution (chirp) for a significant fraction of their lifetimes. Using a galactic population synthesis, we predict ∼2700 of these systems will be observable with a negative chirp of 0.1 yr −2 by a space-based GW detector like LISA . We also show that detections of mass-transferring double WD systems by LISA may provide astronomers with unique ways of probing the physics governing close compact object binaries.

  15. LISA package user guide. Part II: LISA (Long Term Isolation Safety Assessment) program description and user guide

    International Nuclear Information System (INIS)

    Prado, P.; Saltelli, A.; Homma, T.

    1992-01-01

    This manual is subdivided into three parts. In this second part, this document describes the LISA (Long term Isolation Safety Assessment) Code and its submodels. LISA is a tool for analysis of the safety of an underground disposal of nuclear waste. It has the capability to handle nuclide chain of arbitrary length and to evaluate the migration of nuclide through a geosphere medium composed of an arbitrary number of segments. LISA makes use of Monte Carlo methodology to evaluate the uncertainty in the quantity being assessed (eg dose) arising from the uncertainty in the model input parameters. In the present version LISA is equipped with a very simple source term submodel, a relatively complex geosphere and a simplified biosphere. The code is closely associated with its statistical pre-processor code (PREP), which generates the input Monte Carlo sample from the assigned parameter probability density functions and with its post-processor code (SPOP) which provides useful statistics on the output sample (uncertainty and sensitivity analysis). This report describes the general structure of LISA, its subroutines and submodels, the code input ant output files. It is intended to provide the user with enough information to know and run the code as well as the capacity to incorporate different submodels. 15 refs., 6 figs

  16. Propioceptores articulares y musculares

    OpenAIRE

    Vega, José A.

    1999-01-01

    La función de los mecanorreceptores de las articulaciones y músculos se considera asociada a la propiocepción. Sin embargo, existen evidencias de que la propiocepción no sólo depende del morfotipo de mecanorreceptor presente en dichos tejidos sino también de las propiedades de las neuronas sensitivas primarias y las fibras sensitivas asociadas a ellos, así como de su proyección sobre el asta posterior de la médula espinal. Este artículo resume las bases morfológicas de la propi...

  17. The Breadboard model of the LISA telescope assembly

    Science.gov (United States)

    Lucarelli, S.; Scheulen, D.; Kemper, D.; Sippel, R.; Verlaan, A.; Hogenhuis, H.; Ende, D.

    2017-11-01

    The primary goal of the LISA mission is the detection of gravitational waves from astronomical sources in a frequency range of 10-4 to 1 Hz. This requires operational stabilities in the picometer range as well as highly predictable mechanical distortions upon cooling down, outgassing in space, and gravity release. In March 2011 ESA announced a new way forward for the Lclass candidate missions, including LISA. ESA and the scientific community are now studying options for European-only missions that offer a significant reduction of the costs, while maintaining their core science objectives. In this context LISA has become the New Gravitational wave Observatory (NGO). Despite this reformulation, the need for dimensional stability in the picometer range remains valid, and ESA have continued the corresponding LISA Technology Development Activities (TDA's) also in view of NGO. In such frame Astrium GmbH and xperion (Friedrichshafen, Germany) have designed and manufactured an ultra-stable CFRP breadboard of the LISA telescope in order to experimentally demonstrate that the structure and the M1 & M2 mirror mounts are fulfilling the LISA requirements in the mission operational thermal environment. Suitable techniques to mount the telescope mirrors and to support the M1 & M2 mirrors have been developed, with the aim of measuring a system CTE of less than 10-7 K-1 during cooling down to -80°C. Additionally to the stringent mass and stiffness specifications, the required offset design makes the control of relative tilts and lateral displacements between the M1 and M2 mirrors particularly demanding. The thermo-elastic performance of the telescope assembly is going to be experimentally verified by TNO (Delft, The Netherlands) starting from the second half of 2012. This paper addresses challenges faced in the design phase, shows the resulting hardware and present first outcomes of the test campaign performed at TNO.

  18. Inference on inspiral signals using LISA MLDC data

    International Nuclear Information System (INIS)

    Roever, Christian; Stroeer, Alexander; Bloomer, Ed; Christensen, Nelson; Clark, James; Hendry, Martin; Messenger, Chris; Meyer, Renate; Pitkin, Matt; Toher, Jennifer; Umstaetter, Richard; Vecchio, Alberto; Veitch, John; Woan, Graham

    2007-01-01

    In this paper, we describe a Bayesian inference framework for the analysis of data obtained by LISA. We set up a model for binary inspiral signals as defined for the Mock LISA Data Challenge 1.2 (MLDC), and implemented a Markov chain Monte Carlo (MCMC) algorithm to facilitate exploration and integration of the posterior distribution over the nine-dimensional parameter space. Here, we present intermediate results showing how, using this method, information about the nine parameters can be extracted from the data

  19. LISA Pathfinder: Optical Metrology System monitoring during operations

    Science.gov (United States)

    Audley, Heather E.; LISA Pathfinder Collaboration

    2017-05-01

    The LISA Pathfinder (LPF) mission has demonstrated excellent performance. In addition to having surpassed the main mission goals, data has been collected from the various subsystems throughout the duration of the mission. This data is a valuable resource, both for a more complete understanding of the LPF satellite and the differential acceleration measurements, as well as for the design of the future Laser Interferometer Space Antenna (LISA) mission. Initial analysis of the Optical Metrology System (OMS) data was performed as part of daily system monitoring, and more in-depth analyses are ongoing. This contribution presents an overview of these activities along with an introduction to the OMS.

  20. E. Yiannopoulou on Lisa Blackman’s The Body.

    Directory of Open Access Journals (Sweden)

    2009-11-01

    Full Text Available Blackman, Lisa. The Body. Oxford and New York: Berg, 2008. 160 pp. “Is there anything natural about the human body?” (1. This is how Lisa Blackman begins her all too daunting task of reviewing and critically evaluating what has come to be known as “body theory” in the field of sociology. Carefully picking her way among numerous theories on the corporeal that have been produced across the humanities in the last twenty years, Blackman lays out her problematic from the start by asking to know w...

  1. Genetics Home Reference: Fukuyama congenital muscular dystrophy

    Science.gov (United States)

    ... with mental retardation Muscular dystrophy, congenital, Fukuyama type Muscular dystrophy, congenital, with central nervous system involvement Polymicrogyria with muscular dystrophy Related Information How ...

  2. Dismorfia muscular Muscle dysmorphia

    Directory of Open Access Journals (Sweden)

    Sheila Seleri Marques Assunção

    2002-12-01

    Full Text Available Preocupações mórbidas com a imagem corporal eram tidas até recentemente como problemas eminentemente femininos. Atualmente estas preocupações também têm sido encontradas no sexo masculino. A dismorfia muscular é um subtipo do transtorno dismórfico corporal que ocorre principalmente em homens que, apesar da grande hipertrofia muscular, consideram-se pequenos e fracos. Além de estar associada a prejuízos sociais, ocupacionais, recreativos e em outras áreas do funcionamento do indivíduo, a dismorfia muscular é também um fator de risco para o abuso de esteróides anabolizantes. Este artigo aborda aspectos epidemiológicos, etiológicos e padrões clínicos da dismorfia muscular, além de tecer comentários sobre estratégias de tratamento para este transtorno.Morbid concern over body image was considered, until recently, a female issue. Nowadays, it has been viewed as a common male disorder. Muscle dysmorphia, a subtype of a body dysmorphic disorder, affects men who, despite having clear muscular hypertroph,y see themselves as frail and small. Besides being associated to major social, leisure and occupational dysfunction, muscle dysmorphia is also a risk factor for the abuse of steroids. This article describes epidemiological, etiological and clinical characteristics of muscle dysmorphia and comments on its treatment strategy.

  3. Atrofia muscular neurogénica en miopatía nemalínica: ¿Fenómeno primario o secundario? A propósito de un caso

    OpenAIRE

    Alvarez L, Alberto José; Céspedes, Ghislaine; González, Jesús Enrique; Lara, Carmen

    2003-01-01

    La miopatía nemalínica es una miopatía congénita estructural que cursa con debilidad muscular generalmente no progresiva y se caracteriza por la presencia de los llamados "bastones" o "nemalines" en las fibras musculares. Se presenta el estudio anatomoclínico de una forma neonatal severa de la enfermedad en la cual encontramos, además, atrofia muscular neurogénica y escasas motoneuronas de la médula espinal con degeneración simple, sin otra evidencia de denervación. Se revisan otros casos sim...

  4. O papel do esteroide anabolizante sobre a hipertrofia e força muscular em treinamentos de resistência aeróbia e de força

    OpenAIRE

    Carmo,Everton Crivoi do; Bueno Junior,Carlos Roberto; Fernandes,Tiago; Barretti,Diego; Soares,Stéphano Freitas; Silva Junior,Natan Daniel da; Uchida,Marco Carlos; Brum,Patrícia Chakur; Oliveira,Edilamar Menezes de

    2011-01-01

    INTRODUÇÃO: Os efeitos dos esteroides anabolizantes (EA) sobre a massa muscular e força são controversos e dependentes do treinamento realizado e das fibras musculares recrutadas. Com isso, o objetivo deste estudo foi avaliar os efeitos da associação de EA ao treinamento de força ou aeróbio sobre a hipertrofia e força muscular. MÉTODOS: Ratos Wistar (42) foram divididos em seis grupos: sedentário (SC, n = 7), sedentário anabolizante (SA, n = 7), treinado natação controle (TNC, n = 7), treinad...

  5. 240 nm UV LEDs for LISA test mass charge control

    Science.gov (United States)

    Olatunde, Taiwo; Shelley, Ryan; Chilton, Andrew; Serra, Paul; Ciani, Giacomo; Mueller, Guido; Conklin, John

    2015-05-01

    Test Masses inside the LISA Gravitational Reference Sensor must maintain almost pure geodesic motion for gravitational waves to be successfully detected. LISA requires residual test mass accelerations below 3 fm/s2/√Hz at all frequencies between 0.1 and 3 mHz. One of the well-known noise sources is associated with the charges on the test masses which couple to stray electrical potentials and external electromagnetic fields. LISA Pathfinder will use Hg-discharge lamps emitting mostly around 254 nm to discharge the test masses via photoemission in its 2015/16 flight. A future LISA mission launched around 2030 will likely replace the lamps with newer UV-LEDs. Presented here is a preliminary study of the effectiveness of charge control using latest generation UV-LEDs which produce light at 240 nm with energy above the work function of pure Au. Their lower mass, better power efficiency and small size make them an ideal replacement for Hg lamps.

  6. 240 nm UV LEDs for LISA test mass charge control

    International Nuclear Information System (INIS)

    Olatunde, Taiwo; Shelley, Ryan; Chilton, Andrew; Serra, Paul; Ciani, Giacomo; Mueller, Guido; Conklin, John

    2015-01-01

    Test Masses inside the LISA Gravitational Reference Sensor must maintain almost pure geodesic motion for gravitational waves to be successfully detected. LISA requires residual test mass accelerations below 3 fm/s 2 /√Hz at all frequencies between 0.1 and 3 mHz. One of the well-known noise sources is associated with the charges on the test masses which couple to stray electrical potentials and external electromagnetic fields. LISA Pathfinder will use Hg-discharge lamps emitting mostly around 254 nm to discharge the test masses via photoemission in its 2015/16 flight. A future LISA mission launched around 2030 will likely replace the lamps with newer UV-LEDs. Presented here is a preliminary study of the effectiveness of charge control using latest generation UV-LEDs which produce light at 240 nm with energy above the work function of pure Au. Their lower mass, better power efficiency and small size make them an ideal replacement for Hg lamps. (paper)

  7. Multi-Messenger Astronomy: White Dwarf Binaries, LISA and GAIA

    Science.gov (United States)

    Bueno, Michael; Breivik, Katelyn; Larson, Shane L.

    2017-01-01

    The discovery of gravitational waves has ushered in a new era in astronomy. The low-frequency band covered by the future LISA detector provides unprecedented opportunities for multi-messenger astronomy. With the Global Astrometric Interferometer for Astrophysics (GAIA) mission, we expect to discover about 1,000 eclipsing binary systems composed of a WD and a main sequence star - a sizeable increase from the approximately 34 currently known binaries of this type. In advance of the first GAIA data release and the launch of LISA within the next decade, we used the Binary Stellar Evolution (BSE) code simulate the evolution of White Dwarf Binaries (WDB) in a fixed galaxy population of about 196,000 sources. Our goal is to assess the detectability of a WDB by LISA and GAIA using the parameters from our population synthesis, we calculate GW strength h, and apparent GAIA magnitude G. We can then use a scale factor to make a prediction of how many multi- messenger sources we expect to be detectable by both LISA and GAIA in a galaxy the size of the Milky Way. We create binaries 10 times to ensure randomness in distance assignment and average our results. We then determined whether or not astronomical chirp is the difference between the total chirp and the GW chirp. With Astronomical chirp and simulations of mass transfer and tides, we can gather more information about the internal astrophysics of stars in ultra-compact binary systems.

  8. Professor Lisa Aranson on JA Green (a pioonier artist photographer ...

    African Journals Online (AJOL)

    Jonathan Adagogo Green's photographic and artistic contributions working in his countryside, the Niger Delta of Nigeria is reviewed by Professor Lisa Aranson. Aranson in a public lecture presentation on the stand-point of art history thinks of J.A. Green as having operated in two worlds of which he is said to have initiated in ...

  9. 77 FR 56647 - Lisa Jean Sharp: Debarment Order

    Science.gov (United States)

    2012-09-13

    ... Act (the FD&C Act) permanently debarring Lisa Jean Sharp from providing services in any capacity to a...&C Act. Ms. Sharp was given notice of the proposed permanent debarment and an opportunity to request... drug product under the FD&C Act. The factual basis for this conviction is as follows: Ms. Sharp was the...

  10. Sensitivity and parameter-estimation precision for alternate LISA configurations

    International Nuclear Information System (INIS)

    Vallisneri, Michele; Crowder, Jeff; Tinto, Massimo

    2008-01-01

    We describe a simple framework to assess the LISA scientific performance (more specifically, its sensitivity and expected parameter-estimation precision for prescribed gravitational-wave signals) under the assumption of failure of one or two inter-spacecraft laser measurements (links) and of one to four intra-spacecraft laser measurements. We apply the framework to the simple case of measuring the LISA sensitivity to monochromatic circular binaries, and the LISA parameter-estimation precision for the gravitational-wave polarization angle of these systems. Compared to the six-link baseline configuration, the five-link case is characterized by a small loss in signal-to-noise ratio (SNR) in the high-frequency section of the LISA band; the four-link case shows a reduction by a factor of √2 at low frequencies, and by up to ∼2 at high frequencies. The uncertainty in the estimate of polarization, as computed in the Fisher-matrix formalism, also worsens when moving from six to five, and then to four links: this can be explained by the reduced SNR available in those configurations (except for observations shorter than three months, where five and six links do better than four even with the same SNR). In addition, we prove (for generic signals) that the SNR and Fisher matrix are invariant with respect to the choice of a basis of TDI observables; rather, they depend only on which inter-spacecraft and intra-spacecraft measurements are available

  11. GRS vs. OMS Calibration in LISA Pathfinder Data Analysis

    International Nuclear Information System (INIS)

    Meshksar, Neda; Ferraioli, Luigi; Mance, Davor; Zweifel, Peter; Giardini, Domenico; Ten Pierick, Jan

    2017-01-01

    On board LISA Pathfinder spacecraft the test mass displacement along the main measurement axis is sensed in two different ways: optically and electrostatically. We have monitored the relative calibration between the two measurements during the mission science phase. The trend sensitivity of the relative calibration has been computed for different physical parameters, such as temperature, magnetic field, test mass bias voltage and current. (paper)

  12. LISA data analysis using Markov chain Monte Carlo methods

    International Nuclear Information System (INIS)

    Cornish, Neil J.; Crowder, Jeff

    2005-01-01

    The Laser Interferometer Space Antenna (LISA) is expected to simultaneously detect many thousands of low-frequency gravitational wave signals. This presents a data analysis challenge that is very different to the one encountered in ground based gravitational wave astronomy. LISA data analysis requires the identification of individual signals from a data stream containing an unknown number of overlapping signals. Because of the signal overlaps, a global fit to all the signals has to be performed in order to avoid biasing the solution. However, performing such a global fit requires the exploration of an enormous parameter space with a dimension upwards of 50 000. Markov Chain Monte Carlo (MCMC) methods offer a very promising solution to the LISA data analysis problem. MCMC algorithms are able to efficiently explore large parameter spaces, simultaneously providing parameter estimates, error analysis, and even model selection. Here we present the first application of MCMC methods to simulated LISA data and demonstrate the great potential of the MCMC approach. Our implementation uses a generalized F-statistic to evaluate the likelihoods, and simulated annealing to speed convergence of the Markov chains. As a final step we supercool the chains to extract maximum likelihood estimates, and estimates of the Bayes factors for competing models. We find that the MCMC approach is able to correctly identify the number of signals present, extract the source parameters, and return error estimates consistent with Fisher information matrix predictions

  13. GRS vs. OMS Calibration in LISA Pathfinder Data Analysis

    Science.gov (United States)

    Meshksar, Neda; Ferraioli, Luigi; Mance, Davor; ten Pierick, Jan; Zweifel, Peter; Giardini, Domenico; ">LISA Pathfinder colaboration, LISA Pathfinder spacecraft the test mass displacement along the main measurement axis is sensed in two different ways: optically and electrostatically. We have monitored the relative calibration between the two measurements during the mission science phase. The trend sensitivity of the relative calibration has been computed for different physical parameters, such as temperature, magnetic field, test mass bias voltage and current.

  14. Hacia una definición de fibra alimentaria

    OpenAIRE

    García Ochoa, Omar Eduardo; Infante, Ramón Benito; Rivera, Carlos Julio

    2008-01-01

    La fibra alimentaria (FA) ha sido un tópico de considerable interés para los nutricionistas y médicos en estos últimos 35 años. Este artículo presenta un análisis sobre la definición de fibra alimentaria y la controversia que existe al respecto, así como las nuevas propuestas que han surgido para incluir en su definición. La FA fue definida como: todos los polisacáridos no almidones más la lignina, que no pueden ser digeridos o absorbidos en el intestino delgado humano. Esta definición no inc...

  15. Evaluation of Limb-Girdle Muscular Dystrophy

    Science.gov (United States)

    2014-03-06

    Becker Muscular Dystrophy; Limb-Girdle Muscular Dystrophy, Type 2A (Calpain-3 Deficiency); Limb-Girdle Muscular Dystrophy, Type 2B (Miyoshi Myopathy, Dysferlin Deficiency); Limb-Girdle Muscular Dystrophy, Type 2I (FKRP-deficiency)

  16. Morteros Reforzados con Fibras de Bambú

    Directory of Open Access Journals (Sweden)

    Arbeláez Arce Anacilia

    1997-12-01

    Full Text Available El término fibras de bambú, hace referencia al material de desecho (aserrín, seleccionado por diferencia de peso, en inmersión en agua. Se atiene a la definición de fibras que presentan la Norma ASTM C-JI16-89 "Standard Specification for Fiber-Reinforced Concrete ". Se estudian las propiedades físico-mecánicas del mortero 1.3, reforzado con 15, 50 y 100 kg de fibras de bambú, por metro cúbico de mortero, con el objeto de determinar la factibilidad de uso de este material, como matriz para muros estructurales. En el caso de matrices de mortero reforzados para paneles, además de determinar el porcentaje de refuerzo, que permita mantener la resistencia mecánica dentro de los límites establecidos,éste debe lograr un control en el agrietamiento. De hecho en condiciones normales bajo carga, el agrietamiento es inevitable, sea cual fuere la cantidad y calidad de refuerzo usado: Sinembargo, las fibras tienen la propiedad de controlar la propagación del agrietamiento ypor ende transformaruna matrizfrágil, en un material con cierto grado de ductilidad. Los compuestos son probados a compresión axial, flexión e impacto. Las propiedades físicas de absorción de humedad ycontracciones por secado se miden en probetas con dosificación deporcentaje de refuerzo seleccionado de las pruebas mecánicas.

  17. The Engineering of LISA Pathfinder – the quietest Laboratory ever flown in Space

    International Nuclear Information System (INIS)

    Trenkel, Christian; Wealthy, Dave; Dunbar, Neil; Warren, Carl; Schleicher, Alexander; Ziegler, Tobias; Brandt, Nico; Gerndt, Rüdiger

    2017-01-01

    We review the engineering approach adopted to ensure the required gravitational, magnetic, thermal and residual acceleration stability on-board LISA Pathfinder, and present the in-flight results that have been achieved. Arguably, this stability makes LISA Pathfinder the quietest laboratory ever flown in space. The implications for LISA are also discussed. (paper)

  18. Learning about Duchenne Muscular Dystrophy

    Science.gov (United States)

    ... protein. Often these boys are classified as having Becker muscular dystrophy. Genetic testing (looking at the body's genetic instructions) ... National Library of Medicine Web site Duchenne and Becker muscular dystrophy [ghr.nlm.nih.gov] From Genetics Home Reference ...

  19. Desarrollo de materiales compuestos avanzados basados en fibras de carbono para la industria aeroespacial

    OpenAIRE

    Rodriguez, Exequiel Santos

    2015-01-01

    En este trabajo se estudia el desarrollo de materiales compuestos de matriz polimérica reforzados con fibras de carbono para aplicaciones que presentan solicitaciones severas. Este es el caso de la industria aeroespacial, que utiliza componentes en cohetes y aeronaves que se ven sometidos a altas solicitaciones mecánicas y están expuestos a las altas temperaturas. Es por ello que se estudiaron materiales para diversas aplicaciones basados en fibras de carbono: preimpregnados de fibras y resin...

  20. Meaning of Muscular Dystrophy

    Science.gov (United States)

    ... is very similar to Duchenne, except kids with Becker MD may not have problems until much later, when they're teenagers or adults. It takes a long time for their muscles to become weak. How Does a Kid Get Muscular Dystrophy? MD is not contagious (say: con-TAY-juss), ...

  1. Programme [11. international LISA symposium, Zurich (Switzerland), 5-9 September 2016

    International Nuclear Information System (INIS)

    2017-01-01

    Monday, 5th of September 2016 Chair: M. Colpi S. Vitale The LTP experiment on LISA Pathfinder and its first results K. Dooley Advanced LIGO: news from the dark universe B. Schutz LIGOs Black Holes and Science in the LISA Era P. McNamara LISA Pathfinder: First steps to observing gravitational waves from space M. Hewitson In-flight Performance of the Optical Metrology System on LISA Pathfinder W. Weber Physical model of the LISA Pathfinder differential acceleration measurement and its application to LISA K. Danzmann The Status of LISA Chair: O. Jennrich J. Martino On-flight characterization of Coldgas micro-Newton thrusters for Lisa Pathfinder M. Nofrarias Magnetic force noise in LISA Pathfinder L. Ferraioli The LISA Pathfinder GRS Front-End Electronics D. Vetrugno The Δ g workflow: from measured displacements to the differential external acceleration. A. Wittchen Coupling of relative intensity noise and pathlength noise to the length measurement in the optical metrology system of LISA Pathfinder S. Paczkowski Laser frequency stabilisation and interferometer path length differences on LISA Pathfinder R. Giusteri The free-fall mode experiment on LISA Pathfinder: first results P. Wass Electrostatic test-mass force-noise disturbances as measured by LISA Pathfinder R. Dolesi The contribution of Brownian noise from viscous gas damping to the differential acceleration noise measured in LISA Pathfinder between two nominally free falling test masses C. Trenkel The engineering of LISA Pathfinder – the quietest laboratory ever flown in space W. Klipstein LISA-derived Flight Phasemeter on the GRACE Follow-On Mission P. Laufer MEMS Ion Thruster Chips to Significantly Enhance Cold Gas Thruster Lifetime for LISA M. Tinto Enhanced Gravitational Wave Science with LISA and gLISA Tuesday, 6th of September 2016 Chair: P. McNamara F. Ricci Advanced VIRGO: State of the Art C. Belczynski Evolutionary predictions in the advanced LIGO/Virgo era A. Sesana The promise of multi

  2. Description of charging/discharging processes of the LISA sensors

    International Nuclear Information System (INIS)

    Sumner, Tim; Araujo, Henrique; Davidge, David; Howard, Alex; Lee, Chris; Rochester, Geoff; Shaul, Diana; Wass, Peter

    2004-01-01

    The next generation of gravitational experiments in space is likely to use completely isolated proof-masses. For example, LISA uses proof-masses as mirrors in interferometers for gravitational wave astronomy (Bender et al 1998 Pre-phase A report MPG-233 pp 1-191) and STEP uses proof-masses in Earth orbit for an equivalence principle test (Sumner et al 2003 at press). Nongravitational forces will act on these proof-masses if they become charged, through the action of cosmic rays and solar flare particles for example. This paper examines the consequences of proof-mass charging for LISA, and presents results from using GEANT4 to assess the charging processes. Finally, there is a brief discussion of a means of controlling the charge down to an acceptable level

  3. LISA Sources in Milky Way Globular Clusters.

    Science.gov (United States)

    Kremer, Kyle; Chatterjee, Sourav; Breivik, Katelyn; Rodriguez, Carl L; Larson, Shane L; Rasio, Frederic A

    2018-05-11

    We explore the formation of double-compact-object binaries in Milky Way (MW) globular clusters (GCs) that may be detectable by the Laser Interferometer Space Antenna (LISA). We use a set of 137 fully evolved GC models that, overall, effectively match the properties of the observed GCs in the MW. We estimate that, in total, the MW GCs contain ∼21 sources that will be detectable by LISA. These detectable sources contain all combinations of black hole (BH), neutron star, and white dwarf components. We predict ∼7 of these sources will be BH-BH binaries. Furthermore, we show that some of these BH-BH binaries can have signal-to-noise ratios large enough to be detectable at the distance of the Andromeda galaxy or even the Virgo cluster.

  4. The first mock data challenge for LISA Pathfinder

    Energy Technology Data Exchange (ETDEWEB)

    Monsky, A; Hewitson, M; Wanner, G; Nofrarias, M; Diepholz, I; Danzmann, K [Albert-Einstein-Institut, Max-Planck-Institut fuer Gravitationsphysik und Universitaet Hannover, 30167 Hannover (Germany); Ferraioli, L; Hueller, M; Cavalleri, A; Ciani, G; Dolesi, R [Dipartimento di Fisica, Universita di Trento and INFN, Gruppo Collegato di Trento, 38050 Povo, Trento (Italy); Grynagier, A [Institut fuer Flugmechanik und Flugregelung, 70569 Stuttgart (Germany); Armano, M [European Space Agency, ESAC, Villanueva de la Canada, 28692 Madrid (Spain); Benedetti, M [Dipartimento di Ingegneria dei Materiali e Tecnologie Industriali, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Bogenstahl, J [Department of Physics and Astronomy, University of Glasgow, Glasgow (United Kingdom); Bortoluzzi, D; Bosetti, P; Cristofolini, I [Dipartimento di Ingegneria Meccanica e Strutturale, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Brandt, N [Astrium GmbH, 88039 Friedrichshafen (Germany); Cruise, M, E-mail: anneke.monsky@aei.mpg.d [Department of Physics and Astronomy, University of Birmingham, Birmingham (United Kingdom)

    2009-05-07

    The data analysis of the LISA Technology Package (LTP) will comprise a series of discrete experiments, each focusing on a particular noise measurement or characterization of the instrument in various operating modes. Each of these experiments must be analysed and planned in advance of the mission because the results of a given experiment will have an impact on those that follow. As such, a series of mock data challenges (MDCs) will be developed and carried out with the aim of preparing the analysis tools and optimizing the various planned analyses. The first of these MDCs (MDC1) is a simplified treatment of the dynamics along the axis joining the two test masses onboard LISA Pathfinder. The validation of the dynamical model by predicting the spectra of the interferometer output data is shown, a prediction for the data analysis is calculated and, finally, several simulated interferometer data sets are analysed and calibrated to equivalent out-of-loop test mass acceleration.

  5. Alternative opto-mechanical architectures for the LISA instrument

    Energy Technology Data Exchange (ETDEWEB)

    Weise, Dennis R; Marenaci, Pierangelo; Weimer, Peter; Schulte, Hans Reiner; Gath, Peter; Johann, Ulrich, E-mail: dennis.weise@astrium.eads.ne [EADS Astrium GmbH, Claude-Dornier-Str., 88039 Friedrichshafen (Germany)

    2009-03-01

    As part of the on-going LISA Mission Formulation study under ESA contract, EADS Astrium has recently suggested and investigated a variety of novel LISA payload architectures utilizing so-called 'In-Field Pointing' for accommodation of seasonal constellation dynamics. Here, the annual variation in the angle between the interferometer arms of roughly +-1 deg. is compensated by steering the lines of sight of the individual telescopes with a small actuated mirror located in an intermediate pupil plane inside the telescopes. This introduces a certain flexibility for the overall payload configuration and allows for very compact designs. In particular, it enables a 'single active proof mass' mode with a true cold redundancy between a nominal and a backup GRS system on board each spacecraft, and thus enhances mission robustness.

  6. Recent progress at NASA in LISA formulation and technology development

    International Nuclear Information System (INIS)

    Stebbins, R T

    2008-01-01

    Over the last year, the NASA half of the joint LISA project has focused its efforts on responding to a major review, and advancing the formulation and technology development of the mission. The NAS/NRC Beyond Einstein program assessment review will be described, including the outcome. The basis of the LISA science requirements has changed from detection determined by integrated signal-to-noise ratio to observation determined by uncertainty in the estimation of astrophysical source parameters. The NASA team has further defined the spacecraft bus design, participated in many design trade studies and advanced the requirements flow down and the associated current best estimates of performance. Recent progress in technology development is also summarized

  7. Report on the second Mock LISA data challenge

    International Nuclear Information System (INIS)

    Babak, Stanislav; Porter, Edward K; Baker, John G; Benacquista, Matthew J; Cornish, Neil J; Littenberg, Tyson B; Crowder, Jeff; Cutler, Curt; Vallisneri, Michele; Larson, Shane L; Vecchio, Alberto; Auger, Gerard; Barack, Leor; Blaut, Arkadiusz; Bloomer, Ed; Clark, James; Brown, Duncan A; Fairhurst, Stephen; Christensen, Nelson; Gair, Jonathan R

    2008-01-01

    The Mock LISA data challenges are a program to demonstrate LISA data-analysis capabilities and to encourage their development. Each round of challenges consists of several data sets containing simulated instrument noise and gravitational waves from sources of undisclosed parameters. Participants are asked to analyze the data sets and report the maximum information about the source parameters. The challenges are being released in rounds of increasing complexity and realism: here we present the results of Challenge 2, issued in Jan 2007, which successfully demonstrated the recovery of signals from nonspinning supermassive-black-hole binaries with optimal SNRs between ∼10 and 2000, from ∼20 000 overlapping galactic white-dwarf binaries (among a realistically distributed population of 26 million), and from the extreme-mass-ratio inspirals of compact objects into central galactic black holes with optimal SNRs ∼100

  8. Possible LISA follow-on mission scientific objectives

    International Nuclear Information System (INIS)

    Bender, Peter L; Begelman, Mitchell C; Gair, Jonathan R

    2013-01-01

    A major objective that has been suggested for a follow-on mission to a Laser Interferometer Space Antenna (LISA)-type mission is to investigate more completely how intermediate mass black holes were formed and grew in the early universe, before they evolved into the much more massive black holes at the centers of many galaxies today. The actual design of such a follow-on mission will of course depend on what is observed by a LISA-type mission, such as the recently modified proposal for an evolved LISA mission, with the interferometer arm lengths between spacecraft reduced from 5 million to 1 million km. However, the sensitivity goals of a follow-on mission are likely to be influenced strongly by the desire to be able to see mergers of 10 M ⊙ black holes with roughly 3000 M ⊙ or larger intermediate mass black holes out to as large redshifts as possible. Approximate calculations of the expected signal-to-noise have been made for a possible LISA follow-on mission that was suggested about eight years ago (Bender and Begelman 2005 Trends in Space Science and Cosmic Vision 2020 (Noordwijk: ESA Publications Division) pp 33–38), and was called the Advanced Laser Interferometer Antenna. Based on the calculations, it appears that detections out to a redshift of 10 would be possible for 10 M ⊙ black holes spiraling into perhaps 5000 M ⊙ or larger intermediate mass black holes if the extragalactic gravitational wave background due to close white dwarf binaries is in the currently estimated range. (paper)

  9. Cosmological Backgrounds of Gravitational Waves and eLISA

    OpenAIRE

    Dufaux, Jean-Francois

    2012-01-01

    We review cosmological backgrounds of gravitational waves with a particular attention to the scientific potential of the eLISA/NGO mission. After an overview of cosmological backgrounds and detectors, we consider different cosmological sources that could lead to an observable signal. We then study the backgrounds produced by first-order phase transitions and networks of cosmic strings, assessing the prospects for their detection.

  10. Implementation of time-delay interferometry for LISA

    International Nuclear Information System (INIS)

    Tinto, Massimo; Shaddock, Daniel A.; Sylvestre, Julien; Armstrong, J.W.

    2003-01-01

    We discuss the baseline optical configuration for the Laser Interferometer Space Antenna (LISA) mission, in which the lasers are not free-running, but rather one of them is used as the main frequency reference generator (the master) and the remaining five as slaves, these being phase-locked to the master (the master-slave configuration). Under the condition that the frequency fluctuations due to the optical transponders can be made negligible with respect to the secondary LISA noise sources (mainly proof-mass and shot noises), we show that the entire space of interferometric combinations LISA can generate when operated with six independent lasers (the one-way method) can also be constructed with the master-slave system design. The corresponding hardware trade-off analysis for these two optical designs is presented, which indicates that the two sets of systems needed for implementing the one-way method, and the master-slave configuration, are essentially identical. Either operational mode could therefore be implemented without major implications on the hardware configuration. We then derive the required accuracies of armlength knowledge, time synchronization of the onboard clocks, sampling times and time-shifts needed for effectively implementing time-delay interferometry for LISA. We find that an armlength accuracy of about 16 meters, a synchronization accuracy of about 50 ns, and the time jitter due to a presently existing space qualified clock will allow the suppression of the frequency fluctuations of the lasers below to the level identified by the secondary noise sources. A new procedure for sampling the data in such a way to avoid the problem of having time shifts that are not integer multiples of the sampling time is also introduced, addressing one of the concerns about the implementation of time-delay interferometry

  11. UV-LED-based charge control for LISA

    Science.gov (United States)

    Olatunde, Taiwo; Shelley, Ryan; Chilton, Andrew; Ciani, Giacomo; Mueller, Guido; Conklin, John

    2014-03-01

    The test masses inside the LISA gravitational reference sensors (GRS) must maintain almost pure geodesic motion for gravitational waves to be successfully detected. The residual accelerations have to stay below 3fm/s2/rtHz at all frequencies between 0.1 and 3 mHz. One of the well known noise sources is associated with the charges on the test masses which couple to stray electrical potentials and external electro-magnetic fields. The LISA pathfinder (LPF) will use Hg-discharge lamps emitting mostly around 253 nm to discharge the test masses via photoemission in its 2015/16 flight. A future LISA mission launched around 2030 will likely replace the lamps with newer UV-LEDs. UV-LEDs have a lower mass, a better power efficiency, and are smaller than their Hg counterparts. Furthermore, the latest generation produces light at 240 nm, with energy well above the work function of pure gold. I will describe a preliminary design for effective charge control through photoelectric effect by using these LEDs. The effectiveness of this method is verified by taking Quantum Efficiency (QE) measurements which relate the number of electrons emitted to the number of photons incident on the Au test mass surface. This presentation addresses our initial results and future plans which includes implementation and testing in the UF torsion pendulum and space-qualification in a small satellite mission which will launch in the summer of 2014, through a collaboration with Stanford, KACST, and NASA Ames Research Center.

  12. Nested sampling as a tool for LISA data analysis

    International Nuclear Information System (INIS)

    Gair, Jonathan R; Feroz, Farhan; Graff, Philip; Hobson, Michael P; Babak, Stanislav; Petiteau, Antoine; Porter, Edward K

    2010-01-01

    Nested sampling is a technique for efficiently computing the probability of a data set under a particular hypothesis, also called the Bayesian Evidence or Marginal Likelihood, and for evaluating the posterior. MULTINEST is a multi-modal nested sampling algorithm which has been designed to efficiently explore and characterize posterior probability surfaces containing multiple secondary solutions. We have applied the MULTINEST algorithm to a number of problems in gravitational wave data analysis. In this article, we describe the algorithm and present results for several applications of the algorithm to analysis of mock LISA data. We summarise recently published results for a test case in which we searched for two non-spinning black hole binary merger signals in simulated LISA data. We also describe results obtained with MULTINEST in the most recent round of the Mock LISA Data Challenge (MLDC), in which the algorithm was used to search for and characterise both spinning supermassive black hole binary inspirals and bursts from cosmic string cusps. In all these applications, the algorithm found the correct number of signals and efficiently recovered the posterior probability distribution. Moreover, in most cases the waveform corresponding to the best a-posteriori parameters had an overlap in excess of 99% with the true signal.

  13. Nested sampling as a tool for LISA data analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gair, Jonathan R [Institute of Astronomy, Madingley Road, CB3 0HA, Cambridge (United Kingdom); Feroz, Farhan; Graff, Philip; Hobson, Michael P [Astrophysics Group, Cavendish Laboratory, JJ Thomson Avenue, Cambridge CB3 0HE (United Kingdom); Babak, Stanislav; Petiteau, Antoine [Max-Planck-Institut fuer Gravitationsphysik, Am Muehlenberg 1, 14476, Potsdam (Germany); Porter, Edward K, E-mail: jgair@ast.cam.ac.u [APC, UMR 7164, Universite Paris 7 Denis Diderot, 10, rue Alice Domon et Leonie Duquet, 75205 Paris Cedex 13 (France)

    2010-05-01

    Nested sampling is a technique for efficiently computing the probability of a data set under a particular hypothesis, also called the Bayesian Evidence or Marginal Likelihood, and for evaluating the posterior. MULTINEST is a multi-modal nested sampling algorithm which has been designed to efficiently explore and characterize posterior probability surfaces containing multiple secondary solutions. We have applied the MULTINEST algorithm to a number of problems in gravitational wave data analysis. In this article, we describe the algorithm and present results for several applications of the algorithm to analysis of mock LISA data. We summarise recently published results for a test case in which we searched for two non-spinning black hole binary merger signals in simulated LISA data. We also describe results obtained with MULTINEST in the most recent round of the Mock LISA Data Challenge (MLDC), in which the algorithm was used to search for and characterise both spinning supermassive black hole binary inspirals and bursts from cosmic string cusps. In all these applications, the algorithm found the correct number of signals and efficiently recovered the posterior probability distribution. Moreover, in most cases the waveform corresponding to the best a-posteriori parameters had an overlap in excess of 99% with the true signal.

  14. Duchenne muscular dystrophy carriers

    International Nuclear Information System (INIS)

    Matsumura, K.; Nakano, I.

    1989-01-01

    By means of magnetic resonance imaging (MRI), the proton spin-lattice relaxation times (T1 values) of the skeletal muscles were measured in Duchenne muscular dystrophy (DMD) carriers and normal controls. The bound water fraction (BWF) was calculated from the T1 values obtained, according to the fast proton diffusion model. In the DMD carriers, T1 values of the gluteus maximus and quadriceps femoris muscles were significantly higher, and BWFs of these muscles were significantly lower than in normal control. Degenerative muscular changes accompanied by interstitial edema were presumed responsible for this abnormality. No correlation was observed between the muscle T1 and serum creatine kinase values. The present study showed that MRI could be a useful method for studying the dynamic state of water in both normal and pathological skeletal muscles. Its possible utility for DMD carrier detection was discussed briefly. (orig.)

  15. Fibras nervosas retinianas mielinizadas associadas a miopia e ambliopia

    OpenAIRE

    Borges, Bárbara; Cabugueira, Ana; Anjos, Rita; Paixão, Ana; Marques, Margarida; Toscano, Alcina

    2015-01-01

    Introdução: A presença de fibras nervosas mielinizadas na retina está descrita em cerca de 1% da população. Os doentes são habitualmente assintomáticos, embora possam coexistir outras alterações oculares como miopia e ambliopia. Material e Métodos: Descrevem-se 3 casos de crianças com fobras nervosas retinianas mielinizadas unilaterais, associadas a miopia e ambliopia. Resultados: A idade das crianças variou entre 1 e 7 anos. O olho afectado foi o olho direito. A melhor acuidade visual ...

  16. Esclerodermia associada a atividade elétrica muscular continua

    Directory of Open Access Journals (Sweden)

    José Antonio Levy

    1965-12-01

    Full Text Available É relatado o caso de um paciente do sexo masculino, de 15 anos de idade, que apresentava dificuldade para movimentar os braços e para abrir a bôca, além de dispnéia, evoluindo lentamente há dois anos. O exame neurológico revelou hipertonia em todo o corpo, predominando em alguns grupos musculares que se achavam fortemente contraturados, obrigando o paciente a assumir atitudes anormais, impossibilitando-o, ainda, de abrir a bôca e de respirar livremente, dada a grande diminuição da expansibilidade torácica. O exame eletromiográfico revelou a presença de atividade muscular contínua, mesmo durante o repouso, caracterizada por descargas de alta freqüência, as quais persistiram após bloqueio anestésico de nervo periférico e após anestesia geral, sõmente sendo eliminados pelo curare. Com o diagnóstico de esclerodermia e de miosite, embora só a primeira dessas moléstias pudesse ser comprovada anátomo-patològicamente, o paciente foi tratado com corti-costeróides, tendo havido discreta melhora do quadro clínico, sobretudo em relação aos movimentos respiratórios e à abertura da bôca. Tendo, então, o conhecimento de dois casos semelhantes estudados por Isaacs em 1961, com o nome de síndrome da atividade contínua da fibra muscular, os quais haviam sido curados com o uso de hidantoinato de sódio, os autores empregaram esta mesma medicação, tendo verificado, após alguns dias, a diminuição acentuada da atividade anormal pelo exame eletromiográfico.

  17. Estudio sobre la inclusión de fibra dietética en productos reestructurados de pescado

    OpenAIRE

    Sánchez Alonso, Isabel

    2009-01-01

    El objetivo principal de esta memoria es el estudio tecnológico de la inclusión de fibra dietética en músculo de pescado picado y geles elaborados a partir de surimi, ambos conservados en estado congelado. Se estudian dos tipos de fibra dietética: A/ fibra de trigo y B/ concentrado de fibra dietética antioxidante obtenido a partir de subproductos de la industria vinícola. Los dos tipos de fibras dietéticas elegidas, presentan propiedades muy diferentes en sus diversos aspectos funcional-tecno...

  18. Algebraic approach to time-delay data analysis for LISA

    International Nuclear Information System (INIS)

    Dhurandhar, S.V.; Nayak, K. Rajesh; Vinet, J.-Y.

    2002-01-01

    Cancellation of laser frequency noise in interferometers is crucial for attaining the requisite sensitivity of the triangular three-spacecraft LISA configuration. Raw laser noise is several orders of magnitude above the other noises and thus it is essential to bring it down to the level of other noises such as shot, acceleration, etc. Since it is impossible to maintain equal distances between spacecrafts, laser noise cancellation must be achieved by appropriately combining the six beams with appropriate time delays. It has been shown in several recent papers that such combinations are possible. In this paper, we present a rigorous and systematic formalism based on algebraic geometrical methods involving computational commutative algebra, which generates in principle all the data combinations canceling the laser frequency noise. The relevant data combinations form the first module of syzygies, as it is called in the literature of algebraic geometry. The module is over a polynomial ring in three variables, the three variables corresponding to the three time delays around the LISA triangle. Specifically, we list several sets of generators for the module whose linear combinations with polynomial coefficients generate the entire module. We find that this formalism can also be extended in a straightforward way to cancel Doppler shifts due to optical bench motions. The two modules are in fact isomorphic. We use our formalism to obtain the transfer functions for the six beams and for the generators. We specifically investigate monochromatic gravitational wave sources in the LISA band and carry out the maximization over linear combinations of the generators of the signal-to-noise ratios with the frequency and source direction angles as parameters

  19. Cardio-Muscular Conditioner

    Science.gov (United States)

    1993-01-01

    In the mid-sixties, Gary Graham, a Boeing designer, developed a cardiovascular conditioner for a planned Air Force orbiting laboratory. After the project was cancelled, Graham participated in space station conditioning studies for the Skylab program. Twenty years later, he used this expertise to develop the Shuttle 2000-1, a physical therapy and athletic development conditioner, available through Contemporary Designs. The machine is used by football teams, sports clinics and medical rehabilitation centers. Cardiovascular fitness and muscular strength development are promoted through both kinetic and plyometric exercises.

  20. Diagnóstico diferencial das distrofias musculares com referência especial às alterações enzimáticas

    Directory of Open Access Journals (Sweden)

    H. Heick

    1967-06-01

    Full Text Available Depois de apresentar os dados clínicos e genéticos relativos a 221 casos de distrofia muscular progressiva (125 casos do tipo Duchenne, 63 do tipo cintura pélvica e 25 do tipo fácio-escápulo-umeral, os autores analisam os resultados das dosagens sôro-enzimáticas que fizeram; em alguns casos foram pesquisas também as atividades de 25 enzimas em homogeneizados de tecido muscular. Os mesmos exames foram feitos em casos de miopatias de outra etiologia e de distrofias musculares neuropáticas e mielopáticas. Foi verificado que o teor das sôro-enzimas aumenta em todas as formas de distrofia muscular progressiva hereditária. No tipo Duchenne as-atividades enzimáticas são elevadas desde o nascimento das crianças acometidas, precedendo o aparecimento da sintomatologia clínica. Com o progredir da moléstia e com o decorrer dos anos os teores sôro-enzimáticos tendem a diminuir, podendo reduzir-se aos valores normais nas fases finais da moléstia. No tecido muscular não existe diferença significante, no que respeita à composição enzimática, entre os diversos tipos de distrofia muscular progressiva e hereditária. Com exceção de poucas enzimas cuja atividade é maior nos tecidos conjuntivo e adiposo que progressivamente substituem o tecido muscular que entra em atrofia, o teor das mio-enzimas diminui com o progredir da moléstia, como expressão do crescente esgotamento do citoplasma da célula muscular. Nas distrofias musculares neuropáticas e mielopáticas as alterações são idênticas, embora de menor intensidade. Algumas diferenças quantitativas podem ser explicadas pela idade dos pacientes e pela intensidade do processo. A mesma diferença pode ser demonstrada mediante exames histopatológicos: nas formas que acometem crianças (Werdnig-Hoffmann as fibras musculares ainda não denervadas se apresentam com aspecto normal, ao passo que, nas formas do adulto (Kugelberg-Welander, possivelmente pelo desgaste provocado pelos esfor

  1. Limb-Girdle Muscular Dystrophy (LGMD)

    Science.gov (United States)

    ... Marie-Tooth Disease (CMT) Congenital Muscular Dystrophy (CMD) Duchenne Muscular Dystrophy (DMD) Emery-Dreifuss Muscular Dystrophy Endocrine Myopathies Metabolic Diseases of Muscle Mitochondrial Myopathies (MM) Myotonic Dystrophy (DM) Spinal-Bulbar ...

  2. GCR flux 9-day variations with LISA Pathfinder

    International Nuclear Information System (INIS)

    Grimani, C; Benella, S; Fabi, M; Finetti, N; Telloni, D

    2017-01-01

    Galactic cosmic-ray (GCR) energy spectra in the heliosphere vary on the basis of the level of solar activity, the status of solar polarity and interplanetary transient magnetic structures of solar origin. A high counting rate particle detector (PD) aboard LISA Pathfinder (LPF) allows for the measurement of galactic cosmic-ray and solar energetic particle (SEP) integral fluxes at energies > 70 MeV n −1 up to 6500 counts s −1 . Data are gathered with a sampling time of 15 s. A study of GCR flux depressions associated with the third harmonic of the Sun rotation period (∼ 9 days) is presented here. (paper)

  3. Energy transport in mirror machine LISA at electron cyclotron resonance

    International Nuclear Information System (INIS)

    Cunha Rapozo, C. da; Serbeto, A.; Torres-Silva, H.

    1993-01-01

    It is shown that a classical transport calculation is adequate to predict the steady state temperature of the RF produced plasma in LISA machine for both large and small resonant volumes. Temperature anisotropy ranging from 55 to 305 was found which was larger for small resonant volume, and the temperature relaxation was larger at large resonant one. This agrees with the fact that there is a Coulomb relaxation ν c which is proportional to T e -3/2 . It is also shown that the fitting parameter alpha is larger for large resonant volume than for small resonant one. (L.C.J.A.)

  4. A study on the radionuclide migration by means of the code LISA

    International Nuclear Information System (INIS)

    Frenquellucci, F.; Deserti, M.

    1989-01-01

    LISA code (Long Term Isolation Safety Assessment) has been developed by J.R.C. EUROATOM Ispra (Radiochemistry Division) and it's utilized in order to study migration of radionuclides through porous media. Aim of the present work is to analyze LISA's input and output files. A brief description of the code is also performed. As LISA is a research and in development code, its structure is rather complex and an exhaustive description of input/output files is helpful for the user. Version 3 of LISA code, loaded on ENEA's IBM 3090, is avaylable by ENEA-VEL Bologna

  5. Prospects of eLISA for Detecting Galactic Binary Black Holes Similar to GW150914

    OpenAIRE

    Seto, Naoki

    2016-01-01

    We discuss the prospects of eLISA for detecting gravitational waves (GWs) from Galactic binary black holes (BBHs) similar to GW150914. For a comoving merger rate that is consistent with current observation, eLISA is likely to identify at least one BBH with a sufficient signal-to-noise ratio. In addition, eLISA has a potential to measure the eccentricity of the BBH as small as $e\\sim 0.02$, corresponding to the residual value $e\\sim 10^{-6}$ at 10Hz. Therefore, eLISA could provide us with a cr...

  6. Toxic myopathies: muscle biopsy features Miopatia tóxica: biópsia muscular

    Directory of Open Access Journals (Sweden)

    Rosana Herminia Scola

    2007-03-01

    Full Text Available Several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. We present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. The most common substances inducing myopathy were corticosteroids (56.2% followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. The investigation showed normal serum creatine kinase levels in 65.4%, myopathic pattern of the needle electromyography in 40% and the more frequent histological diagnosis of the muscle biopsy was type 2 fiber atrophy (59.3%. Clinical features, etiology, course of the disease, serum levels of muscular enzymes, electromyographic features and, especially, muscle biopsy features are discussed.Diversos medicamentos e substâncias tóxicas podem causar alterações musculares e são causas freqüentes de miopatia adquirida. Apresentamos uma série de 32 pacientes, predomínio de pacientes adulto jovens, com miopatia tóxica. As substâncias mais relacionadas com a miopatia foram os corticosteróides (56,2% seguidos pelo propoxifeno, neurolépticos, zidovudina e drogas indutoras de hipocalemia. A investigação mostrou níveis normais de creatino quinase sérica em 65,4%, eletromiografia de agulha com padrão miopático em 40% e o mais freqüente diagnóstico histológico da biópsia muscular foi atrofia de fibras do tipo 2 (59,3%. As manifestações clínicas, etiologia, tempo de evolução, nível sérico das enzimas musculares, alterações da eletroneuromiografia e, especialmente, da biópsia muscular são discutidos.

  7. Influencia de los componentes del concreto reforzado con fibras en sus propiedades mecánicas

    OpenAIRE

    González Salcedo, Luis Octavio

    2013-01-01

    El concreto es un material de construcción y estructural por excelencia, elaborado con cemento, agua, agregados, adiciones minerales y aditivos químicos. Sin embargo, es conocido también como un material quebradizo, característica que es contrarrestada con la incorporación de un volumen de fibra como reforzamiento de su matriz basada en cemento. La incorporación de fibra hace que se denomine como concreto reforzado con fibra, o simplemente fibrorreforzado, y se caracteriza c...

  8. Plan estratégico Sudamericana de Fibras (2016-2020)

    OpenAIRE

    Herrera Chávez, Santiago; Leyva Forcelledo, Johanna; Ríos Oroz, Erika

    2016-01-01

    La presente investigación tiene como finalidad elaborar un plan estratégico para la empresa Sudamericana de Fibras S.A.; así como proponer recomendaciones con el fin que pueda crecer, en los niveles local y regional, con un modelo sostenible. La empresa Sudamericana de Fibras S.A. opera en el país desde el año 1972 y se dedica a la elaboración de fibras acrílicas, material que se encuentra al inicio de la cadena de suministro en el rubro textil, y permite otorgar propiedades extraordinarias a...

  9. The magnetic diagnostics subsystem of the LISA Technology Package

    Energy Technology Data Exchange (ETDEWEB)

    Diaz-Aguilo, M; Garcia-Berro, E [Departament de Fisica Aplicada, Universitat Politecnica de Catalunya, c/Esteve Terrades, 5, 08860 Castelldefels (Spain); Lobo, A; Mateos, N; Sanjuan, J, E-mail: marc.diaz.aguilo@fa.upc.ed [Institut d' Estudis Espacials de Catalunya, c/Gran Capita 2-4, Edif. Nexus 104, 08034 Barcelona (Spain)

    2010-05-01

    The Magnetic Diagnostics Subsystem of the LISA Technology Package (LTP) on board the LISA Pathfinder (LPF) spacecraft includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at the positions they occupy. However, their readouts do not provide a direct measurement of the magnetic field at the positions of the test masses. Therefore, an interpolation method must be implemented to obtain this information. However, such interpolation process faces serious difficulties. Indeed, the size of the interpolation region is excessive for a linear interpolation to be reliable, and the number of magnetometer channels does not provide sufficient data to go beyond that poor approximation. Recent research points to a possible alternative to address the magnetic interpolation problem by means of neural network algorithms. The key point of this approach is the ability neural networks have to learn from suitable training data representing the magnetic field behaviour. Despite the large distance to the test masses and the insufficient magnetic readings, artificial neural networks are able to significantly reduce the estimation error to acceptable levels. The learning efficiency can be best improved by making use of data obtained from on-ground measurements prior to mission launch in all relevant satellite locations and under real operation conditions. Reliable information on that appears to be essential for a meaningful assessment of magnetic noise in the LTP.

  10. Towards an improved magnetic diagnostic system for LISA

    International Nuclear Information System (INIS)

    Mateos, I; Lobo, A; Sanjuan, J; Ramos-Castro, J; Nofrarias, M

    2009-01-01

    The current design, and material implementation of the magnetic field sensing in the LISA Technology Package (LTP) on board LISA Pathfinder (LPF), is based on a set of 4 high-precision 3-axis fluxgate magnetometers. In order to avoid magnetic disturbances on the LTP proof masses (TM 's), originated by the sensors themselves, these are placed somewhat far from the TM's, which results in partial field information losses. We are currently investigating alternative magnetic sensing techniques, based on AMR (Anisotropic Magnetoresistive) devices. These are much smaller in size than fluxgates, therefore a more numerous array can be thought of for flight. In addition, there is a chance that they may be attached closer to the TM's, thereby enhancing magnetic field sensing spacial resolution. Several issues need to be addressed, such as real sensitivity (including electronics noise) and set/reset trigger procedures. A brief overview about the stability of the magnetic fields and gradients generated in the LTP by means of the coil will also be given. This paper show the latest results of our research.

  11. The magnetic diagnostics subsystem of the LISA Technology Package

    International Nuclear Information System (INIS)

    Diaz-Aguilo, M; Garcia-Berro, E; Lobo, A; Mateos, N; Sanjuan, J

    2010-01-01

    The Magnetic Diagnostics Subsystem of the LISA Technology Package (LTP) on board the LISA Pathfinder (LPF) spacecraft includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at the positions they occupy. However, their readouts do not provide a direct measurement of the magnetic field at the positions of the test masses. Therefore, an interpolation method must be implemented to obtain this information. However, such interpolation process faces serious difficulties. Indeed, the size of the interpolation region is excessive for a linear interpolation to be reliable, and the number of magnetometer channels does not provide sufficient data to go beyond that poor approximation. Recent research points to a possible alternative to address the magnetic interpolation problem by means of neural network algorithms. The key point of this approach is the ability neural networks have to learn from suitable training data representing the magnetic field behaviour. Despite the large distance to the test masses and the insufficient magnetic readings, artificial neural networks are able to significantly reduce the estimation error to acceptable levels. The learning efficiency can be best improved by making use of data obtained from on-ground measurements prior to mission launch in all relevant satellite locations and under real operation conditions. Reliable information on that appears to be essential for a meaningful assessment of magnetic noise in the LTP.

  12. Classifying LISA gravitational wave burst signals using Bayesian evidence

    International Nuclear Information System (INIS)

    Feroz, Farhan; Graff, Philip; Hobson, Michael P; Lasenby, Anthony; Gair, Jonathan R

    2010-01-01

    We consider the problem of characterization of burst sources detected by the Laser Interferometer Space Antenna (LISA) using the multi-modal nested sampling algorithm, MultiNest. We use MultiNest as a tool to search for modelled bursts from cosmic string cusps, and compute the Bayesian evidence associated with the cosmic string model. As an alternative burst model, we consider sine-Gaussian burst signals, and show how the evidence ratio can be used to choose between these two alternatives. We present results from an application of MultiNest to the last round of the Mock LISA Data Challenge, in which we were able to successfully detect and characterize all three of the cosmic string burst sources present in the release data set. We also present results of independent trials and show that MultiNest can detect cosmic string signals with signal-to-noise ratio (SNR) as low as ∼7 and sine-Gaussian signals with SNR as low as ∼8. In both cases, we show that the threshold at which the sources become detectable coincides with the SNR at which the evidence ratio begins to favour the correct model over the alternative.

  13. Disentangling the magnetic force noise contribution in LISA Pathfinder

    International Nuclear Information System (INIS)

    Armano, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Baird, J; Bortoluzzi, D; Brandt, N; Fitzsimons, E; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Dunbar, N; Ferraioli, L

    2015-01-01

    Magnetically-induced forces on the inertial masses on-board LISA Pathfinder are expected to be one of the dominant contributions to the mission noise budget, accounting for up to 40%. The origin of this disturbance is the coupling of the residual magnetization and susceptibility of the test masses with the environmental magnetic field. In order to fully understand this important part of the noise model, a set of coils and magnetometers are integrated as a part of the diagnostics subsystem. During operations a sequence of magnetic excitations will be applied to precisely determine the coupling of the magnetic environment to the test mass displacement using the on-board magnetometers. Since no direct measurement of the magnetic field in the test mass position will be available, an extrapolation of the magnetic measurements to the test mass position will be carried out as a part of the data analysis activities. In this paper we show the first results on the magnetic experiments during an end- to-end LISA Pathfinder simulation, and we describe the methods under development to map the magnetic field on-board. (paper)

  14. Revised electrostatic model of the LISA Pathfinder inertial sensor

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, Nico [Astrium GmbH, 88039 Friedrichshafen (Germany); Fichter, Walter, E-mail: nico.brandt@astrium.eads.ne [iFR, Universitaet Stuttgart, Pfaffenwaldring 7a, 70569 Stuttgart (Germany)

    2009-03-01

    A comprehensive electrostatic finite-element (FE) analysis of the LISA Pathfinder Inertial Sensor (IS) has been carried out at Astrium GmbH. Starting with a detailed geometrical model of the IS housing and test mass (TM) flight units, FE results were derived from multiple analyses runs applying the Maxwell 3D field simulation software. The electrostatic forces and torques on the TM in 6DoF, as well as all non-negligible capacitances between the TM, the 18 electrodes, and the housing, have been extracted for different TM translations and rotations. The results of the FE analyses were expected to confirm the existing IS electrostatic model predictions used for performance analysis, simulations, and on-board algorithms. Major discrepancies were found, however, between the results and the model used so far. In general, FE results give considerably larger capacitance values than the equivalent infinite non-parallel plate estimates. In contrast, the FE derived forces and torques are in general significantly lower compared to the analytic IS electrostatic model predictions. In this paper, these results are discussed in detail and the reasons for the deviations are elaborated. Based on these results, an adapted analytic IS electrostatic model is proposed that reflects the electrostatic forces, torques, and stiffness values in the LISA Pathfinder IS significantly more accurate.

  15. Revised electrostatic model of the LISA Pathfinder inertial sensor

    International Nuclear Information System (INIS)

    Brandt, Nico; Fichter, Walter

    2009-01-01

    A comprehensive electrostatic finite-element (FE) analysis of the LISA Pathfinder Inertial Sensor (IS) has been carried out at Astrium GmbH. Starting with a detailed geometrical model of the IS housing and test mass (TM) flight units, FE results were derived from multiple analyses runs applying the Maxwell 3D field simulation software. The electrostatic forces and torques on the TM in 6DoF, as well as all non-negligible capacitances between the TM, the 18 electrodes, and the housing, have been extracted for different TM translations and rotations. The results of the FE analyses were expected to confirm the existing IS electrostatic model predictions used for performance analysis, simulations, and on-board algorithms. Major discrepancies were found, however, between the results and the model used so far. In general, FE results give considerably larger capacitance values than the equivalent infinite non-parallel plate estimates. In contrast, the FE derived forces and torques are in general significantly lower compared to the analytic IS electrostatic model predictions. In this paper, these results are discussed in detail and the reasons for the deviations are elaborated. Based on these results, an adapted analytic IS electrostatic model is proposed that reflects the electrostatic forces, torques, and stiffness values in the LISA Pathfinder IS significantly more accurate.

  16. T.D Lee and Lisa Randall visit ATLAS

    CERN Multimedia

    Pauline Gagnon

    Professor Tsung-Dao Lee, who received the Nobel Prize for Physics in 1957 for postulating that parity is not conserved in weak interactions, visited the ATLAS detector this month. He is seen here in the company of Peter Jenni, spokesperson for ATLAS. T.D. Lee is still very active at over 80, pursuing his theory work to this day. Professor Lisa Randall from Harvard University, the well-known theorist behind the Randall-Sundrum theory for extra dimensions, was also part of the group visiting the ATLAS detector. She is seen here with Fabiola Gianotti, deputy spokesperson for ATLAS. Lisa Randall's two initial papers have been quoted both more than 2500 times, making her the most cited theoretical physicist in the world in the last five years as of last autumn - a total of about 10,000 citations! One wonders here if Peter is pointing to a CP-violating graviton spotted in the ATLAS cavern... From left to right: Fabiola Gianotti, Gustaaf Brooijmans, convener of the ATLAS Exotics physics gro...

  17. Aplicaciones del cemento reforzado con fibra de vidrio (GRC

    Directory of Open Access Journals (Sweden)

    Barros Llerena, Ángel

    1981-12-01

    Full Text Available Not available.

    El presente artículo tiene como objeto dar a conocer la utilización de fibras de vidrio como refuerzo de los cementos. Se da una breve reseña histórica, se mencionan sus características y comportamiento. Además se presenta un caso práctico y reciente de utilización en la fabricación de elementos de fachada del Estadio «Santiago Bernabéu» del Real Madrid C. de F., y se completa con una relación de los actuales y futuros usos del G.R.C. (glass reinforced cement, denominación inglesa del material más comúnmente utilizado.

  18. Despliegue red fibra óptica hasta el hogar (FTTH)

    OpenAIRE

    Velasco de Miguel, Javier

    2017-01-01

    En este PFC se pretende dar una visión general de lo que es un despliegue FTTH presentando un caso teórico práctico. Está compuesto en 4 partes. En la primera parte se presenta una explicación de la evolución de las redes fijas de banda ancha llegando al uso actual de la fibra como medio de transmisión. Después, se desarrolla una parte teórica del funcionamiento y elementos presentes en las redes de comunicación ópticas. Explicaremos las partes en las que se divide la red FTTH, y se pre...

  19. ESTUDO DA SECAGEM DA FIBRA RESIDUAL DO ABACAXI

    Directory of Open Access Journals (Sweden)

    T. G. M. WAUGHON

    2009-01-01

    Full Text Available

    O objetivo deste trabalho foi caracterizar o resíduo fibroso gerado na industrialização do suco de abacaxi (Ananas comosus L. e estudar seu beneficiamento, através da secagem, visando obter um produto rico em fibras dietéticas. O resíduo caracterizado apresentou um elevado teor de fibras (32,95% b.s.. A secagem foi realizada em secador de leito fixo, em camada delgada, utilizando planejamento fatorial completo a três níveis, com triplicata no ponto central. As variáveis de entrada foram: temperatura (50 ºC, 60 ºC e 70ºC e velocidade de circulação do ar (2,0 m/s; 2,5 m/s e 3,0 m/s. As variáveis de resposta avaliadas foram: umidade de equilíbrio, tempo de secagem, taxa de secagem à velocidade constante e coloração do produto. Os resultados obtidos através da análise de variância mostraram que a temperatura foi a variável de entrada que apresentou maior influência sobre as variáveis de resposta analisadas, não exercendo influência significativa apenas sobre a cor do produto.

  20. White-dwarf-white-dwarf galactic background in the LISA data

    International Nuclear Information System (INIS)

    Edlund, Jeffrey A.; Tinto, Massimo; Krolak, Andrzej; Nelemans, Gijs

    2005-01-01

    LISA (Laser Interferometer Space Antenna) is a proposed space mission, which will use coherent laser beams exchanged between three remote spacecraft to detect and study low-frequency cosmic gravitational radiation. In the low part of its frequency band, the LISA strain sensitivity will be dominated by the incoherent superposition of hundreds of millions of gravitational wave signals radiated by inspiraling white-dwarf binaries present in our own Galaxy. In order to estimate the magnitude of the LISA response to this background, we have simulated a synthesized population that recently appeared in the literature. Our approach relies on entirely analytic expressions of the LISA time-delay interferometric responses to the gravitational radiation emitted by such systems, which allows us to implement a computationally efficient and accurate simulation of the background in the LISA data. We find the amplitude of the galactic white-dwarf binary background in the LISA data to be modulated in time, reaching a minimum equal to about twice that of the LISA noise for a period of about two months around the time when the Sun-LISA direction is roughly oriented towards the Autumn equinox. This suggests that, during this time period, LISA could search for other gravitational wave signals incoming from directions that are away from the galactic plane. Since the galactic white-dwarf background will be observed by LISA not as a stationary but rather as a cyclostationary random process with a period of 1 yr, we summarize the theory of cyclostationary random processes, present the corresponding generalized spectral method needed to characterize such process, and make a comparison between our analytic results and those obtained by applying our method to the simulated data. We find that, by measuring the generalized spectral components of the white-dwarf background, LISA will be able to infer properties of the distribution of the white-dwarf binary systems present in our Galaxy

  1. O papel do esteroide anabolizante sobre a hipertrofia e força muscular em treinamentos de resistência aeróbia e de força

    Directory of Open Access Journals (Sweden)

    Everton Crivoi do Carmo

    2011-06-01

    Full Text Available INTRODUÇÃO: Os efeitos dos esteroides anabolizantes (EA sobre a massa muscular e força são controversos e dependentes do treinamento realizado e das fibras musculares recrutadas. Com isso, o objetivo deste estudo foi avaliar os efeitos da associação de EA ao treinamento de força ou aeróbio sobre a hipertrofia e força muscular. MÉTODOS: Ratos Wistar (42 foram divididos em seis grupos: sedentário (SC, n = 7, sedentário anabolizante (SA, n = 7, treinado natação controle (TNC, n = 7, treinado natação anabolizante (TNA, n = 7, treinado força controle (TFC, n = 7 e treinado força anabolizante (TFA, n = 7. O EA foi administrado duas vezes por semana (10mg/kg/semana. Os protocolos de treinamento foram realizados durante 10 semanas, cinco sessões semanais. Foram avaliadas a hipertrofia dos músculos sóleo, plantar e gastrocnêmio (massa muscular corrigida pelo comprimento da tíbia, a proteína total muscular (Bradford e a força muscular em patas traseiras (testes de resistência à inclinação. RESULTADOS: Não foram observadas diferenças significantes na hipertrofia do músculo sóleo. Os grupos TFC e TFA apresentaram, respectivamente, hipertrofia de 18% e 31% no músculo plantar comparado ao grupo SC. A hipertrofia foi 13% maior no grupo TFA em relação ao grupo TFC. Resultados semelhantes foram encontrados no músculo gastrocnêmio. Os grupos TFC e TFA apresentaram significantes aumentos na quantidade total de proteína nos músculos plantares, sendo essa mais pronunciada no grupo TFA e positivamente correlaciona a hipertrofia muscular. Observamos aumento de força nas patas traseiras nos grupos TCF e TAF. CONCLUSÃO: A administração de EA ou sua associação ao treinamento aeróbio não aumenta a massa muscular e força. Porém, à associação ao treinamento de força leva a maior hipertrofia muscular em fibras glicolíticas. Portanto, o tipo de treinamento físico, recrutamento muscular e características das fibras

  2. Beyond the Required LISA Free-Fall Performance: New LISA Pathfinder Results down to 20 μ Hz

    Science.gov (United States)

    Armano, M.; Audley, H.; Baird, J.; Binetruy, P.; Born, M.; Bortoluzzi, D.; Castelli, E.; Cavalleri, A.; Cesarini, A.; Cruise, A. M.; Danzmann, K.; de Deus Silva, M.; Diepholz, I.; Dixon, G.; Dolesi, R.; Ferraioli, L.; Ferroni, V.; Fitzsimons, E. D.; Freschi, M.; Gesa, L.; Gibert, F.; Giardini, D.; Giusteri, R.; Grimani, C.; Grzymisch, J.; Harrison, I.; Heinzel, G.; Hewitson, M.; Hollington, D.; Hoyland, D.; Hueller, M.; Inchauspé, H.; Jennrich, O.; Jetzer, P.; Karnesis, N.; Kaune, B.; Korsakova, N.; Killow, C. J.; Lobo, J. A.; Lloro, I.; Liu, L.; López-Zaragoza, J. P.; Maarschalkerweerd, R.; Mance, D.; Meshksar, N.; Martín, V.; Martin-Polo, L.; Martino, J.; Martin-Porqueras, F.; Mateos, I.; McNamara, P. W.; Mendes, J.; Mendes, L.; Nofrarias, M.; Paczkowski, S.; Perreur-Lloyd, M.; Petiteau, A.; Pivato, P.; Plagnol, E.; Ramos-Castro, J.; Reiche, J.; Robertson, D. I.; Rivas, F.; Russano, G.; Slutsky, J.; Sopuerta, C. F.; Sumner, T.; Texier, D.; Thorpe, J. I.; Vetrugno, D.; Vitale, S.; Wanner, G.; Ward, H.; Wass, P. J.; Weber, W. J.; Wissel, L.; Wittchen, A.; Zweifel, P.

    2018-02-01

    In the months since the publication of the first results, the noise performance of LISA Pathfinder has improved because of reduced Brownian noise due to the continued decrease in pressure around the test masses, from a better correction of noninertial effects, and from a better calibration of the electrostatic force actuation. In addition, the availability of numerous long noise measurement runs, during which no perturbation is purposely applied to the test masses, has allowed the measurement of noise with good statistics down to 20 μ Hz . The Letter presents the measured differential acceleration noise figure, which is at (1.74 ±0.01 ) fm s-2/√{Hz } above 2 mHz and (6 ±1 ) ×10 fm s-2/√{Hz } at 20 μ Hz , and discusses the physical sources for the measured noise. This performance provides an experimental benchmark demonstrating the ability to realize the low-frequency science potential of the LISA mission, recently selected by the European Space Agency.

  3. Limb girdle muscular dystrophies

    DEFF Research Database (Denmark)

    Vissing, John

    2016-01-01

    PURPOSE OF REVIEW: The aim of the study was to describe the clinical spectrum of limb girdle muscular dystrophies (LGMDs), the pitfalls of the current classification system for LGMDs, and emerging therapies for these conditions. RECENT FINDINGS: Close to half of all LGMD subtypes have been...... or are registered in other classification systems for muscle disease. On the contrary, diseases that fulfill classical criteria for LGMD have found no place in the LGMD classification system. These shortcomings call for revision/creation of a new classification system for LGMD. The rapidly expanding gene sequencing...... capabilities have helped to speed up new LGMD discoveries, and unveiled pheno-/genotype relations. Parallel to this progress in identifying new LGMD subtypes, emerging therapies for LGMDs are under way, but no disease-specific treatment is yet available for nonexperimental use. SUMMARY: The field of LGMD...

  4. Probing the Universe with Gravitational Waves: the Laser Interferometer Space Antenna (LISA)

    NARCIS (Netherlands)

    Prince, T.A.; Binetruy, P.; Centrella, J.; Finn, L.; Hogan, C.; Nelemans, G.A.; Phinney, S.

    2007-01-01

    - For the LISA International Science Team: LISA is a joint NASA/ESA space mission designed to measure gravitational waves in the band from 0.1 mHz to 0.1 Hz, a band that is richly populated by strong sources of gravitational waves. Signals will come from a wider range of sources: massive black holes

  5. Control system design for the constellation acquisition phase of the LISA mission

    Energy Technology Data Exchange (ETDEWEB)

    Cirillo, Francesca; Gath, Peter F, E-mail: francesca.cirillo@astrium.eads.ne, E-mail: peter.gath@astrium.eads.ne [Astrium GmbH Satellites, 88039 Friedrichshafen (Germany)

    2009-03-01

    The objective of the constellation acquisition phase for the LISA mission is to establish the three laser links between the three spacecraft of the LISA constellation so that the interferometric measurements for the science experiment can commence. The laser beam acquisition for LISA is extremely challenging given the 5 million km distance between the spacecraft, the inherent limits of the attitude sensors accuracy, the orbit determination accuracy issues and the time required to phase-lock the incoming and outgoing laser signals. This paper presents the design of the control system for the acquisition phase of the LISA constellation: the acquisition operational procedure is outlined, guidance laws are defined together with the Gyro Mode attitude control principle, which implements a Kalman filter for disturbances rejection purposes. Constellation-wide non-linear simulations demonstrate that the LISA constellation acquisition phase is feasible by means of the proposed control strategy.

  6. Control system design for the constellation acquisition phase of the LISA mission

    International Nuclear Information System (INIS)

    Cirillo, Francesca; Gath, Peter F

    2009-01-01

    The objective of the constellation acquisition phase for the LISA mission is to establish the three laser links between the three spacecraft of the LISA constellation so that the interferometric measurements for the science experiment can commence. The laser beam acquisition for LISA is extremely challenging given the 5 million km distance between the spacecraft, the inherent limits of the attitude sensors accuracy, the orbit determination accuracy issues and the time required to phase-lock the incoming and outgoing laser signals. This paper presents the design of the control system for the acquisition phase of the LISA constellation: the acquisition operational procedure is outlined, guidance laws are defined together with the Gyro Mode attitude control principle, which implements a Kalman filter for disturbances rejection purposes. Constellation-wide non-linear simulations demonstrate that the LISA constellation acquisition phase is feasible by means of the proposed control strategy.

  7. Orocaecal transit time in Duchenne muscular dystrophy.

    OpenAIRE

    Korman, S H; Bar-Oz, B; Granot, E; Meyer, S

    1991-01-01

    Smooth muscle degeneration may occur in Duchenne muscular dystrophy. We measured fasting orocaecal transit time in patients with advanced Duchenne muscular dystrophy and other muscular dystrophies and in healthy controls. No significant differences were found. In contrast to reports of gastric hypomotility in Duchenne muscular dystrophy, we found no evidence of impaired small intestinal motility.

  8. Síndrome de Straatsma. Caso familiar de mielinización de fibras nerviosas

    Directory of Open Access Journals (Sweden)

    Fanny Campos-Jiménez

    2014-01-01

    Full Text Available En condiciones normales sólo ocurre mielinización de fibras del nervio óptico por detrás de la lámina cribosa, pero se observa mielinización de parte de la capa de fibras nerviosas de la retina en el 0.32% a 0.98% de los pacientes. la mielinización intraocular generalmente es yuxtapapilar, y las fibras toman un aspecto característico: manchas blancas, nacaradas, parecidas a una pluma, que siguen la dirección de las fibras de la retina y a veces ocultan la papila. Aparte de estas características fundoscópicas, la mayoría de los pacientes son normales. Se ha encontrado que puede haber una asociación entre la mielinización de las fibras de la retina y una miopía ipsilateral, y también se ha observado ambliopía y estrabismo. Se describe un caso de mielinización de fibras nerviosas, en madre e hija, hecho que sugiere un factor genético en su génesis.

  9. Relativistic analysis of the LISA long range optical links

    International Nuclear Information System (INIS)

    Chauvineau, Bertrand; Regimbau, Tania; Vinet, Jean-Yves; Pireaux, Sophie

    2005-01-01

    The joint ESA/NASA LISA mission consists of three spacecraft on heliocentric orbits, flying in a triangular formation of 5 Mkm each side, linked by infrared optical beams. The aim of the mission is to detect gravitational waves in a low frequency band. For properly processing the scientific data, the propagation delays between spacecraft must be accurately known. We thus analyze the propagation of light between spacecraft in order to systematically derive the relativistic effects due to the static curvature of the Schwarzschild space-time in which the spacecraft are orbiting with time-varying light distances. In particular, our analysis allows us to evaluate rigorously the Sagnac effect, and the gravitational (Einstein) redshift

  10. LISA Pathfinder drag-free control and system implications

    International Nuclear Information System (INIS)

    Fichter, Walter; Gath, Peter; Vitale, Stefano; Bortoluzzi, Daniele

    2005-01-01

    The top-level requirement of the LISA Pathfinder mission is the verification of pure relative free fall between two test masses with an accuracy of about 3 x 10 -14 m s -2 Hz -1/2 in a measurement bandwidth between 1 mHz and 30 mHz. The drag-free control system is one of the key technology elements that shall be verified. Its design is strongly connected to the overall system and experimental design, in particular, via the following issues: the differential test mass motion and thus the science measurements depend on the control system; design constraints, such as negative stiffness of test masses and electrostatic actuation cross-talk, have an impact on science and control system performance; derived requirements for control system components, in particular, the micro-propulsion system, must be within reasonable and feasible limits. In this paper, the control design approach is outlined and the system-related issues are addressed

  11. The LISA Pathfinder interferometry-hardware and system testing

    Energy Technology Data Exchange (ETDEWEB)

    Audley, H; Danzmann, K; MarIn, A Garcia; Heinzel, G; Monsky, A; Nofrarias, M; Steier, F; Bogenstahl, J [Albert-Einstein-Institut, Max-Planck-Institut fuer Gravitationsphysik und Universitaet Hannover, 30167 Hannover (Germany); Gerardi, D; Gerndt, R; Hechenblaikner, G; Johann, U; Luetzow-Wentzky, P; Wand, V [EADS Astrium GmbH, Friedrichshafen (Germany); Antonucci, F [Dipartimento di Fisica, Universita di Trento and INFN, Gruppo Collegato di Trento, 38050 Povo, Trento (Italy); Armano, M [European Space Astronomy Centre, European Space Agency, Villanueva de la Canada, 28692 Madrid (Spain); Auger, G; Binetruy, P [APC UMR7164, Universite Paris Diderot, Paris (France); Benedetti, M [Dipartimento di Ingegneria dei Materiali e Tecnologie Industriali, Universita di Trento and INFN, Gruppo Collegato di Trento, Mesiano, Trento (Italy); Boatella, C, E-mail: antonio.garcia@aei.mpg.de [CNES, DCT/AQ/EC, 18 Avenue Edouard Belin, 31401 Toulouse, Cedex 9 (France)

    2011-05-07

    Preparations for the LISA Pathfinder mission have reached an exciting stage. Tests of the engineering model (EM) of the optical metrology system have recently been completed at the Albert Einstein Institute, Hannover, and flight model tests are now underway. Significantly, they represent the first complete integration and testing of the space-qualified hardware and are the first tests on an optical system level. The results and test procedures of these campaigns will be utilized directly in the ground-based flight hardware tests, and subsequently during in-flight operations. In addition, they allow valuable testing of the data analysis methods using the MATLAB-based LTP data analysis toolbox. This paper presents an overview of the results from the EM test campaign that was successfully completed in December 2009.

  12. Commissioning and operating experience with the LISA superconducting accelerator

    International Nuclear Information System (INIS)

    Castellano, M.; Ferrario, M.; Minestrini, M.; Patteri, P.; Tazzioli, F.; Kulinski, S.

    1996-06-01

    The commissioning of the LISA superconducting (SC) RF electron linac at INFN Frascati Laboratories has been concluded although, due to a change in program priorities, the full possibilities of the machine have not been exploited. In this report the authors illustrate the results achieved so far and the difficulties encountered in commissioning, with the hope that this material might be some of help to those who intend to start the enterprise of building a SC linac in a non specialized environment. The part concerning the SC system is particularly stressed, but a relevant attention is also devoted to the traditional room temperature injector, the proper setting of which is fundamental to achieving the high beam quality that such a machine allows

  13. Detecting white dwarf binaries in Mock LISA Data Challenge 3

    International Nuclear Information System (INIS)

    Blaut, A; Krolak, A; Babak, S

    2009-01-01

    We present a strategy for detecting gravitational wave signals from the Galactic white dwarf binaries in the Mock LISA Data Challenge 3 (MLDC3) and estimate their parameters. Our method is based on the matched filtering in the form of the F-statistic. We perform the search on three-dimensional space (sky coordinate and frequency of gravitational wave) below 3 mHz and include the fourth parameter (frequency derivative) at high frequencies. A template bank is used to search for the strongest signal in the data, then we remove it and repeat the search until we do not have signals in the data above a preselected threshold. For the template bank, we construct an optimal grid that realizes the best lattice covering with a constraint such that the nodes of the grid coincide with the Fourier frequencies. This enables the use of the fast Fourier transform algorithm to calculate the F-statistic.

  14. Strong lensing of gravitational waves as seen by LISA.

    Science.gov (United States)

    Sereno, M; Sesana, A; Bleuler, A; Jetzer, Ph; Volonteri, M; Begelman, M C

    2010-12-17

    We discuss strong gravitational lensing of gravitational waves from the merging of massive black hole binaries in the context of the LISA mission. Detection of multiple events would provide invaluable information on competing theories of gravity, evolution and formation of structures and, possibly, constraints on H0 and other cosmological parameters. Most of the optical depth for lensing is provided by intervening massive galactic halos, for which wave optics effects are negligible. Probabilities to observe multiple events are sizable for a broad range of formation histories. For the most optimistic models, up to ≲ 4 multiple events with a signal to noise ratio ≳ 8 are expected in a 5-year mission. Chances are significant even for conservative models with either light (≲ 60%) or heavy (≲ 40%) seeds. Because of lensing amplification, some intrinsically too faint signals are brought over threshold (≲ 2 per year).

  15. Interferometry for the LISA technology package (LTP) aboard SMART-2

    International Nuclear Information System (INIS)

    Heinzel, G; Braxmaier, C; Schilling, R; Ruediger, A; Robertson, D; Plate, M te; Wand, V; Arai, K; Johann, U; Danzmann, K

    2003-01-01

    The interferometer of the LISA technology package (LTP) on SMART-2 is needed to verify the performance of the gravitational sensors by monitoring the distance between two test masses with a noise level of 10 pm Hz -1/2 between 3 mHz and 30 mHz. It must continuously track the motion of the test mass distance while that distance changes by many μm with a speed of up to 20 μm s -1 , without losing track of the sign of the motion and without exerting any influence on the test masses that might lead to a motion above that level. As a result of a detailed comparison study, a heterodyne Mach-Zehnder interferometer was selected as the baseline for the SMART-2 mission. Its design and expected performance are described in this paper

  16. Aspectos morfológicos de biópsias musculares em equinos com miopatia sob forma de surto

    Directory of Open Access Journals (Sweden)

    Rogério M. Amorim

    2011-07-01

    Full Text Available As miopatias em equinos são classificadas de acordo com aspectos clínicos, morfológicos e moleculares, em três grandes grupos: não associadas ao exercício, associadas ao exercício e devido alteração da condução elétrica do sarcolema. Apesar dos avanços no diagnóstico, a literatura ainda relata surtos de miopatia em equinos sem etiologia esclarecida em diversos países. O objetivo desse estudo foi descrever as alterações histológicas e histoquímicas de biópsias musculares de equinos acometidos por miopatia. Sete equinos da raça Quarto de Milha, com 18-24 meses de idade, apresentaram sinais clínicos de miopatia. Dentre esses animais, cinco apresentaram sinais subagudos leves a moderados e dois apresentaram sinais hiperagudos severos e decúbito lateral. Foram realizadas biópsias musculares utilizando a técnica percutânea, por agulha tipo Bergström, no músculo glúteo médio em todos os animais acometidos. As amostras foram processadas por meio de técnicas histológicas (HE, Tricrômio de Gomori modificado e histoquímicas (PAS, NADH, ATPase. Nos quadros clínicos mais leves, a principal alteração encontrada foi a presença de fibras vermelhas rajadas do tipo I e IIA, que estão associadas às alterações do metabolismo oxidativo e das funções mitocondriais, como ocorrem nas miopatias mitocondriais. Também foram observadas fibras atróficas do tipo I e IIA, além da presença de agregados subsarcolemais. Nos quadros mais severos o tecido muscular apresentou infiltrado inflamatório, aumento de colágeno, fagocitose, necrose, calcificação e regeneração muscular. Diante dos achados morfológicos, da resposta à terapia com vitamina E e Se e da baixa mortalidade quando comparado aos relatos de miopatia atípica, conclui-se que esse surto foi desencadeado por lesões mitocondriais, caracterizadas pelas fibras musculares vermelhas rajadas, possivelmente devido uma quebra da homeostase de vitamina E e Se, sendo compat

  17. The effects of orbital motion on LISA time delay interferometry

    International Nuclear Information System (INIS)

    Cornish, Neil J; Hellings, Ronald W

    2003-01-01

    In an effort to eliminate laser phase noise in laser interferometer spaceborne gravitational wave detectors, several combinations of signals have been found that allow the laser noise to be cancelled out while gravitational wave signals remain. This process is called time delay interferometry (TDI). In the papers that defined the TDI variables, their performance was evaluated in the limit that the gravitational wave detector is fixed in space. However, the performance depends on certain symmetries in the armlengths that are available if the detector is fixed in space, but that will be broken in the actual rotating and flexing configuration produced by the LISA orbits. In this paper we investigate the performance of these TDI variables for the real LISA orbits. First, addressing the effects of rotation, we verify Daniel Shaddock's result that the Sagnac variables α (t), β (t) and γ (t) will not cancel out the laser phase noise, and we also find the same result for the symmetric Sagnac variable ζ (t). The loss of the latter variable would be particularly unfortunate since this variable also cancels out gravitational wave signal, allowing instrument noise in the detector to be isolated and measured. Fortunately, we have found a set of more complicated TDI variables, which we call Δ Sagnac variables, one of which accomplishes the same goal as ζ (t) to good accuracy. Finally, however, as we investigate the effects of the flexing of the detector arms due to non-circular orbital motion, we show that all variables, including the interferometer variables, X(t), Y(t) and Z(t), which survive the rotation-induced loss of direction symmetry, will not completely cancel laser phase noise when the armlengths are changing with time. This unavoidable problem will place a stringent requirement on laser stability of ∼5 Hz Hz -1/2

  18. Muscular Dystrophy: Hope Through Research

    Science.gov (United States)

    ... of muscular dystrophy appeared in 1830, when Sir Charles Bell wrote an essay about an illness that ... linked disorder to their sons but their daughters will be carriers of that disorder. Carrier females occasionally ...

  19. Amyloidotic muscle pseudohypertrophy: case report Pseudo-hipertrofia muscular associada com amiloidose: relato de caso

    Directory of Open Access Journals (Sweden)

    Rosana Herminia Scola

    2001-09-01

    Full Text Available The authors report one case of amyloidosis associated with muscular pseudohypertrophy in a 46-year-old woman, who developed weakness, macroglossia and muscle hypertrophy associated with primary systemic amyloidosis. Electromyography showed a myopathic pattern and bilateral carpal tunnel syndrome. The muscle biopsy presented with a type I and II fiber hypertrophy and infiltration of amyloid material in the interstitious space and artery walls. She underwent bone marrow transplantation with stabilization and subjective improvement of the clinical picture.Descreve-se um caso de pseudo-hipertrofia muscular associada a amiloidose primária em uma paciente do sexo feminino, com 46 anos, que apresentava astenia e macroglossia. O estudo eletromiográfico mostrou padrão miopático e síndrome do túnel do carpo, bilateral. A biópsia muscular revelou hipertrofia de fibras tipo I e II, com infiltração de material amilóide no interstício e parede dos vasos, principalmente arteriais. A paciente foi submetida a transplante autólogo de medula óssea, evoluindo com estabilização do quadro e um sentimento subjetivo de melhora.

  20. Proyecto de apertura de una Planta de Recolección de Fibras Secundarias en la zona norte de la República del Perú, Piura

    OpenAIRE

    Coellar Neira, Paulo Geovanny

    2005-01-01

    Fibras Secundarias. La utilización de fibras secundarias en la elaboración y producción de papel. La recuperación de fibras secundarias. El Mercado Ecuatoriano de Fibras Secundarias. Análisis de Mercado. Determinación del mercado potencial, comparación con países desarrollados. ¿Cómo potenciar el mercado nacional de recuperación de fibras?. Marco legal actual y deseado. Análisis y comentario. Fuentes alternativas de aprovisionamiento de fibras secundarias. Análisis del potencial mercado del P...

  1. THE LISA GRAVITATIONAL WAVE FOREGROUND: A STUDY OF DOUBLE WHITE DWARFS

    International Nuclear Information System (INIS)

    Ruiter, Ashley J.; Belczynski, Krzysztof; Benacquista, Matthew; Williams, Gabriel; Larson, Shane L.

    2010-01-01

    Double white dwarfs (WDs) are expected to be a source of confusion-limited noise for the future gravitational wave observatory LISA. In a specific frequency range, this 'foreground noise' is predicted to rise above the instrumental noise and hinder the detection of other types of signals, e.g., gravitational waves arising from stellar-mass objects inspiraling into massive black holes. In many previous studies, only detached populations of compact object binaries have been considered in estimating the LISA gravitational wave foreground signal. Here, we investigate the influence of compact object detached and Roche-Lobe overflow (RLOF) Galactic binaries on the shape and strength of the LISA signal. Since >99% of remnant binaries that have orbital periods within the LISA sensitivity range are WD binaries, we consider only these binaries when calculating the LISA signal. We find that the contribution of RLOF binaries to the foreground noise is negligible at low frequencies, but becomes significant at higher frequencies, pushing the frequency at which the foreground noise drops below the instrumental noise to >6 mHz. We find that it is important to consider the population of mass-transferring binaries in order to obtain an accurate assessment of the foreground noise on the LISA data stream. However, we estimate that there still exists a sizeable number (∼11,300) of Galactic double WD binaries that will have a signal-to-noise ratio >5, and thus will be potentially resolvable with LISA. We present the LISA gravitational wave signal from the Galactic population of WD binaries, show the most important formation channels contributing to the LISA disk and bulge populations, and discuss the implications of these new findings.

  2. Annual modulation of the galactic binary confusion noise background and LISA data analysis

    International Nuclear Information System (INIS)

    Seto, Naoki

    2004-01-01

    We study the anisotropies of the galactic confusion noise background and its effects on LISA data analysis. LISA has two data streams of gravitational wave signals relevant for the low frequency regime. Because of the anisotropies of the background, the matrix for their confusion noises has off-diagonal components and depends strongly on the orientation of the detector plane. We find that the sky-averaged confusion noise level √(S(f)) could change by a factor of 2 in 3 months and would be minimum when the orbital position of LISA is around either the spring or autumn equinox

  3. Science with the space-based interferometer LISA. IV: probing inflation with gravitational waves

    International Nuclear Information System (INIS)

    Bartolo, Nicola; Guzzetti, Maria Chiara; Liguori, Michele; Matarrese, Sabino

    2016-01-01

    We investigate the potential for the LISA space-based interferometer to detect the stochastic gravitational wave background produced from different mechanisms during inflation. Focusing on well-motivated scenarios, we study the resulting contributions from particle production during inflation, inflationary spectator fields with varying speed of sound, effective field theories of inflation with specific patterns of symmetry breaking and models leading to the formation of primordial black holes. The projected sensitivities of LISA are used in a model-independent way for various detector designs and configurations. We demonstrate that LISA is able to probe these well-motivated inflationary scenarios beyond the irreducible vacuum tensor modes expected from any inflationary background.

  4. Science with the space-based interferometer LISA. IV: Probing inflation with gravitational waves

    CERN Document Server

    Bartolo, Nicola; Domcke, Valerie; Figueroa, Daniel G.; Garcia-Bellido, Juan; Guzzetti, Maria Chiara; Liguori, Michele; Matarrese, Sabino; Peloso, Marco; Petiteau, Antoine; Ricciardone, Angelo; Sakellariadou, Mairi; Sorbo, Lorenzo; Tasinato, Gianmassimo

    2016-01-01

    We investigate the potential for the LISA space-based interferometer to detect the stochastic gravitational wave background produced from different mechanisms during inflation. Focusing on well-motivated scenarios, we study the resulting contributions from particle production during inflation, inflationary spectator fields with varying speed of sound, effective field theories of inflation with specific patterns of symmetry breaking and models leading to the formation of primordial black holes. The projected sensitivities of LISA are used in a model-independent way for various detector designs and configurations. We demonstrate that LISA is able to probe these well-motivated inflationary scenarios beyond the irreducible vacuum tensor modes expected from any inflationary background.

  5. Muscular dystrophy in a dog resembling human becker muscular dystrophy.

    Science.gov (United States)

    Baroncelli, A B; Abellonio, F; Pagano, T B; Esposito, I; Peirone, B; Papparella, S; Paciello, O

    2014-05-01

    A 3-year-old, male Labrador retriever dog was presented with clinical signs of progressive exercise intolerance, bilateral elbow extension, rigidity of the forelimbs, hindlimb flexion and kyphosis. Microscopical examination of muscle tissue showed marked variability in myofibre size, replacement of muscle with mature adipose tissue and degeneration/regeneration of muscle fibres, consistent with muscular dystrophy. Immunohistochemical examination for dystrophin showed markedly reduced labelling with monoclonal antibodies specific for the rod domain and the carboxy-terminal of dystrophin, while expression of β-sarcoglycan, γ-sarcoglycan and β-dystroglycan was normal. Immunoblotting revealed a truncated dystrophin protein of approximately 135 kDa. These findings supported a diagnosis of congenital canine muscular dystrophy resembling Becker muscular dystrophy in man. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Radiation pressure calibration and test mass reflectivities for LISA Pathfinder

    International Nuclear Information System (INIS)

    Korsakova, Natalia; Kaune, Brigitte

    2017-01-01

    This paper describes a series of experiments which were carried out during the main operations of LISA Pathfinder. These experiments were performed by modulating the power of the measurement and reference beams. In one series of experiments the beams were sequentially switched on and off. In the other series of experiments the powers of the beams were modulated within 0.1% and 1% of the constant power. These experiments use recordings of the total power measured on the photodiodes to infer the properties of the Optical Metrology System (OMS), such as reflectivities of the test masses and change of the photodiode efficiencies with time. In the first case the powers are back propagated from the different photodiodes to the same place on the optical bench to express the unknown quantities in the measurement with the complimentary photodiode measurements. They are combined in the way that the only unknown left is the test mass reflectivities. The second experiment compared two estimates of the force applied to the test masses due to the radiation pressure that appears because of the beam modulations. One estimate of the force is inferred from the measurements of the powers on the photodiodes and propagation of this measurement to the test masses. The other estimation of the force is done by calculating it from the change in the main scientific output of the instrument – differential displacement of the two test masses. (paper)

  7. Analog phase lock between two lasers at LISA power levels

    International Nuclear Information System (INIS)

    Diekmann, Christian; Steier, Frank; Sheard, Benjamin; Heinzel, Gerhard; Danzmann, Karsten

    2009-01-01

    This paper presents the implementation of an analog optical phase-locked-loop with an offset frequency of about 20MHz between two lasers, where the detected light powers were of the order of 31 pW and 200 μW. The goal of this setup was the design and characterization of a photodiode transimpedance amplifier for application in LISA. By application of a transimpedance amplifier designed to have low noise and low power consumption, the phase noise between the two lasers was a factor of two above the shot noise limit down to 60mHz. The achievable phase sensitivity depends ultimately on the available power of the highly attenuated master laser and on the input current noise of the transimpedance amplifier of the photodetector. The limiting noise source below 60mHz was the analog phase measurement system that was used in this experiment. A digital phase measurement system that is currently under development at the AEI will be used in the near future. Its application should improve the sensitivity.

  8. Analog phase lock between two lasers at LISA power levels

    Energy Technology Data Exchange (ETDEWEB)

    Diekmann, Christian; Steier, Frank; Sheard, Benjamin; Heinzel, Gerhard; Danzmann, Karsten, E-mail: Christian.Diekmann@aei.mpg.d [Max-Planck-Institute for Gravitational Physics, Callinstr. 38, D-30167 Hannover (Germany)

    2009-03-01

    This paper presents the implementation of an analog optical phase-locked-loop with an offset frequency of about 20MHz between two lasers, where the detected light powers were of the order of 31 pW and 200 muW. The goal of this setup was the design and characterization of a photodiode transimpedance amplifier for application in LISA. By application of a transimpedance amplifier designed to have low noise and low power consumption, the phase noise between the two lasers was a factor of two above the shot noise limit down to 60mHz. The achievable phase sensitivity depends ultimately on the available power of the highly attenuated master laser and on the input current noise of the transimpedance amplifier of the photodetector. The limiting noise source below 60mHz was the analog phase measurement system that was used in this experiment. A digital phase measurement system that is currently under development at the AEI will be used in the near future. Its application should improve the sensitivity.

  9. Radiation pressure calibration and test mass reflectivities for LISA Pathfinder

    Science.gov (United States)

    Korsakova, Natalia; Kaune, Brigitte; LPF Collaboration

    2017-05-01

    This paper describes a series of experiments which were carried out during the main operations of LISA Pathfinder. These experiments were performed by modulating the power of the measurement and reference beams. In one series of experiments the beams were sequentially switched on and off. In the other series of experiments the powers of the beams were modulated within 0.1% and 1% of the constant power. These experiments use recordings of the total power measured on the photodiodes to infer the properties of the Optical Metrology System (OMS), such as reflectivities of the test masses and change of the photodiode efficiencies with time. In the first case the powers are back propagated from the different photodiodes to the same place on the optical bench to express the unknown quantities in the measurement with the complimentary photodiode measurements. They are combined in the way that the only unknown left is the test mass reflectivities. The second experiment compared two estimates of the force applied to the test masses due to the radiation pressure that appears because of the beam modulations. One estimate of the force is inferred from the measurements of the powers on the photodiodes and propagation of this measurement to the test masses. The other estimation of the force is done by calculating it from the change in the main scientific output of the instrument - differential displacement of the two test masses.

  10. Planning for chemical disasters at Point Lisas, Trinidad and Tobago

    International Nuclear Information System (INIS)

    Mathur, M.N.

    1995-01-01

    No major chemical disaster has taken place so far in Trinidad and Tobago. Even so, in view of the numerous hazards that the various chemical handling plants deal with at Point Lisas, the country has to be prepared to deal with chemical disasters. The country's emergency preparedness plan for chemical disasters aims to localize the emergency, if possible, eliminate it and minimize the effects of the accident on people and property. The hazards of ammonia, hydrogen, chlorine, hydrocarbons and methanol release can have devastating effects on the workers and the residents in the vicinity of the plants. The Emergency Plan identifies an Emergency Co-ordinating Officer who would take command of the off-site activities and coordinate the activities of Works Management, Local Authority, Police, Fire Services, Defence Force, Health Authority and Factory Inspectorate. Resources of fire fighting, medical treatment, telecommunications, waste management and public education have to be enhanced immediately. In the long term a new fire station and a new county hospital have to be built, some housing settlements have to be phased out and non-essential staff relocated

  11. LISA Pathfinder: An important first step towards a space-based gravitational wave observatory

    Science.gov (United States)

    Thorpe, James

    2017-08-01

    ESA's LISA Pathfinder mission was launched on Dec 3rd, 2015 and completed earlier this Summer. During this relatively short mission, Pathfinder at its two science payloads, Europe's LISA Technology Package and NASA's Disturbance Reduction System, demonstrated several techniques and technologies that enable development of a future space-based gravitational wave observatory. Most notably, Pathfinder demonstrated that the technique of drag-free flight could be utilized to place a test mass in near-perfect free-fall, with residual accelerations at the femto-g level in the milliHertz band. Additionally, technologies such as precision bonded optical structures for metrology, micropropulsion systems, and non-contact charge control, were successfully tested, retiring risk for LISA. In this talk, I will present an overview of Pathfinder's results to date and some perspective on how this success will be leveraged into realizing LISA.

  12. Report on the first round of the Mock LISA Data Challenges

    International Nuclear Information System (INIS)

    Arnaud, K A; Auger, G; Babak, S

    2007-01-01

    The Mock LISA Data Challenges (MLDCs) have the dual purpose of fostering the development of LISA data analysis tools and capabilities, and demonstrating the technical readiness already achieved by the gravitational-wave community in distilling a rich science payoff from the LISA data output. The first round of MLDCs has just been completed: nine challenges consisting of data sets containing simulated gravitational-wave signals produced either by galactic binaries or massive black hole binaries embedded in simulated LISA instrumental noise were released in June 2006 with deadline for submission of results at the beginning of December 2006. Ten groups have participated in this first round of challenges. All of the challenges had at least one entry which successfully characterized the signal to better than 95% when assessed via a correlation with phasing ambiguities accounted for. Here, we describe the challenges, summarize the results and provide a first critical assessment of the entries

  13. Deficiência muscular de carnitina: relato de 8 casos com estudo clínico, eletromiográfico, histoquímico e bioquímico muscular

    Directory of Open Access Journals (Sweden)

    Lineu Cesar Werneck

    1985-09-01

    Full Text Available São relatados os casos de 8 pacientes, sendo 7 do sexo masculino, cuja idade variou entre 5 dias e 64 anos. Sete pacientes apresentavam diminuição da força muscular e todos apresentavam, nas biópsias musculares, acúmulo de lipídios. Os sintomas iniciaram nos primeiros dias de vida em três pacientes, na infância em dois, na idade adulta em dois; um dos casos apresentava-se assinto-mático aos 64 anos de idade (heterozigoto?. Em graus variáveis os pacientes apresentavam dificuldades na deglutição, hipotonia, atrofia muscular, dificuldades na mastigação, parestesias em membros inferiores, hepatomegalia e esplenome-galia. Cinco casos tinham história familiar e um relatava recorrências dos sintomas. Todos apresentavam aumento dos enzimas séricos, principalmente da creatinoquinase. A eletromiografia foi compatível a envolvimento muscular primário em um caso, desenervação em dois e neuromiopático em dois, não tendo sido realizada em três casos. Na biópsia muscular, em todos os casos, além do acúmulo de lipídios, ocorriam: componente de desenervação em 4, miopa-tia crônica em 4, atrofia de fibras do tipo II em um. Em dois casos, as alterações histológicas eram sugestivas de atrofia espinhal infantil. Um dos casos, possivelmente pertencente à forma sistêmica de deficiência de carnitina, possuía importante envolvimento miocárdico, vindo a falecer. São discutidos aspectos clínicos, metabólicos e terapêuticos das deficiências musculares de carnitina.

  14. Stellar binary black holes in the LISA band: a new class of standard sirens

    Science.gov (United States)

    Del Pozzo, Walter; Sesana, Alberto; Klein, Antoine

    2018-04-01

    The recent Advanced LIGO detections of coalescing black hole binaries (BHBs) imply a large population of such systems emitting at milli-Hz frequencies, accessible to the Laser Interferometer Space Antenna (LISA). We show that these systems provide a new class of cosmological standard sirens. Direct LISA luminosity distance - Dl - measurements, combined with the inhomogeneous redshift - z - distribution of possible host galaxies provide an effective way to populate the Dl-z diagram at z arm-length, respectively.

  15. LISA extreme-mass-ratio inspiral events as probes of the black hole mass function

    International Nuclear Information System (INIS)

    Gair, Jonathan R.; Tang, Christopher; Volonteri, Marta

    2010-01-01

    One of the sources of gravitational waves for the proposed space-based gravitational wave detector, the Laser Interferometer Space Antenna (LISA), are the inspirals of compact objects into supermassive black holes in the centers of galaxies--extreme-mass-ratio inspirals (EMRIs). Using LISA observations, we will be able to measure the parameters of each EMRI system detected to very high precision. However, the statistics of the set of EMRI events observed by LISA will be more important in constraining astrophysical models than extremely precise measurements for individual systems. The black holes to which LISA is most sensitive are in a mass range that is difficult to probe using other techniques, so LISA provides an almost unique window onto these objects. In this paper we explore, using Bayesian techniques, the constraints that LISA EMRI observations can place on the mass function of black holes at low redshift. We describe a general framework for approaching inference of this type--using multiple observations in combination to constrain a parametrized source population. Assuming that the scaling of the EMRI rate with the black-hole mass is known and taking a black-hole distribution given by a simple power law, dn/dlnM=A 0 (M/M * ) α 0 , we find that LISA could measure the parameters to a precision of Δ(lnA 0 )∼0.08, and Δ(α 0 )∼0.03 for a reference model that predicts ∼1000 events. Even with as few as 10 events, LISA should constrain the slope to a precision ∼0.3, which is the current level of observational uncertainty in the low-mass slope of the black-hole mass function. We also consider a model in which A 0 and α 0 evolve with redshift, but find that EMRI observations alone do not have much power to probe such an evolution.

  16. Constraining stellar binary black hole formation scenarios with eLISA eccentricity measurements

    OpenAIRE

    Nishizawa, Atsushi; Sesana, Alberto; Berti, Emanuele; Klein, Antoine

    2016-01-01

    A space-based interferometer such as eLISA could observe few to few thousands progenitors of black hole binaries (BHBs) similar to those recently detected by Advanced LIGO. Gravitational radiation circularizes the orbit during inspiral, but some BHBs retain a measurable eccentricity at the low frequencies where eLISA is most sensitive. The eccentricity of a BHB carries precious information about its formation channel: BHBs formed in the field, in globular clusters, or close to a massive black...

  17. Muscular atrophy in diabetic neuropathy

    DEFF Research Database (Denmark)

    Andersen, H; Gadeberg, P C; Brock, B

    1997-01-01

    Diabetic patients with polyneuropathy develop motor dysfunction. To establish whether motor dysfunction is associated with muscular atrophy the ankle dorsal and plantar flexors of the non-dominant leg were evaluated with magnetic resonance imaging in 8 patients with symptomatic neuropathy, in 8 non...... confirmed that the atrophy predominated distally. We conclude that muscular atrophy underlies motor weakness at the ankle in diabetic patients with polyneuropathy and that the atrophy is most pronounced in distal muscles of the lower leg indicating that a length dependent neuropathic process explains...

  18. Metabolismo muscular en el ejercicio

    OpenAIRE

    Martín Martín, Laura

    2017-01-01

    Fundamentos: Cada vez son más las personas que realizan algún tipo de actividad física, pero pocas son las que poseen un verdadero conocimiento de los procesos que se desencadenan a nivel muscular y la influencia de la alimentación en la misma. El objetivo de este trabajo es ofrecer información de manera general sobre el metabolismo muscular. Métodos: Revisión bibliográfica de artículos y documentos consultando bases de datos y libros. La mayor parte del análisis ha sido ext...

  19. Genetics Home Reference: spinal muscular atrophy

    Science.gov (United States)

    ... difficulty breathing. Children with this type often have joint deformities (contractures) that impair movement. In severe cases, ... Proximal spinal muscular atrophy Washington University, St. Louis: Neuromuscular Disease Center: Spinal Muscular Atrophy Patient Support and ...

  20. Respiratory function in facioscapulohumeral muscular dystrophy 1

    NARCIS (Netherlands)

    Wohlgemuth, M.; Horlings, G.C.; Kooi, E.L. van der; Gilhuis, H.J.; Hendriks, J.C.M.; Maarel, S.M. van der; Engelen, B.G.M. van; Heijdra, Y.F.; Padberg, G.W.A.M.

    2017-01-01

    To test the hypothesis that wheelchair dependency and (kypho-)scoliosis are risk factors for developing respiratory insufficiency in facioscapulohumeral muscular dystrophy, we examined 81 patients with facioscapulohumeral muscular dystrophy 1 of varying degrees of severity ranging from ambulatory

  1. What Are the Types of Muscular Dystrophy?

    Science.gov (United States)

    ... muscular dystrophy? There are more than 30 forms of muscular dystrophy (MD), with information on the primary types included in the table below. 1 Duchenne (DMD) What It Is Common Symptoms How It ...

  2. Optimal statistic for detecting gravitational wave signals from binary inspirals with LISA

    CERN Document Server

    Rogan, A

    2004-01-01

    A binary compact object early in its inspiral phase will be picked up by its nearly monochromatic gravitational radiation by LISA. But even this innocuous appearing candidate poses interesting detection challenges. The data that will be scanned for such sources will be a set of three functions of LISA's twelve data streams obtained through time-delay interferometry, which is necessary to cancel the noise contributions from laser-frequency fluctuations and optical-bench motions to these data streams. We call these three functions pseudo-detectors. The sensitivity of any pseudo-detector to a given sky position is a function of LISA's orbital position. Moreover, at a given point in LISA's orbit, each pseudo-detector has a different sensitivity to the same sky position. In this work, we obtain the optimal statistic for detecting gravitational wave signals, such as from compact binaries early in their inspiral stage, in LISA data. We also present how the sensitivity of LISA, defined by this optimal statistic, vari...

  3. Constraining stellar binary black hole formation scenarios with eLISA eccentricity measurements

    Science.gov (United States)

    Nishizawa, Atsushi; Sesana, Alberto; Berti, Emanuele; Klein, Antoine

    2017-03-01

    A space-based interferometer such as the evolved Laser Interferometer Space Antenna (eLISA) could observe a few to a few thousands of progenitors of black hole binaries (BHBs) similar to those recently detected by Advanced LIGO. Gravitational radiation circularizes the orbit during inspiral, but some BHBs retain a measurable eccentricity at the low frequencies where eLISA is the most sensitive. The eccentricity of a BHB carries precious information about its formation channel: BHBs formed in the field, in globular clusters, or close to a massive black hole (MBH) have distinct eccentricity distributions in the eLISA band. We generate mock eLISA observations, folding in measurement errors, and using a Bayesian model selection, we study whether eLISA measurements can identify the BHB formation channel. We find that a handful of observations would suffice to tell whether BHBs were formed in the gravitational field of an MBH. Conversely, several tens of observations are needed to tell apart field formation from globular cluster formation. A 5-yr eLISA mission with the longest possible armlength is desirable to shed light on BHB formation scenarios.

  4. Hormigones de alta resistencia con nano-adiciones y fibras de acero

    OpenAIRE

    Alizo Mirabal, Manuel Arturo

    2015-01-01

    El presente Trabajo Fin de Máster consistió en determinar la influencia que pueden poseer las nano-adiciones de Sílice y Alúmina y fibras de acero en un Hormigón de Alta Resistencia. Partiendo de una dosificación de Hormigón de Alta Resistencia conocida, que contenía humo de Sílice (10%) y fibras de poliolefina (3kg/m3), se les procedió a sustituir por la incorporación de nano-adiciones de Sílice y Alúmina (7% y 3% respectivamente) y añadiendo fibras de acero en lugar de poliolefina. En el pr...

  5. CONCRETO REFORZADO CON FIBRA NATURAL DE ORIGEN ANIMAL (PLUMAS DE AVES)

    OpenAIRE

    Díaz Cabrejos, Pablo; Universidad Señor de Sipán SAC

    2016-01-01

    Para mejorar las propiedades del concreto como la resistencia y la durabilidad ha sido investigado a través de los años. Con ayuda de la tecnología se han obtenido óptimos diseños para concretos reforzados con fibras pero su aplicación comercial aún está limitada debido a que estas fibras incrementan el costo.Con la presente investigación se pretende determinar el contenido óptimo de las fibras en el concreto teniendo en cuenta la inhibición causadas por la contracción plástica. Se estudiará ...

  6. Estudio de viabilidad de cajones marítimos con hormigón con fibras

    OpenAIRE

    Ramos Marquès, Òscar Gonçal

    2017-01-01

    En este TFM se estudia la viabilidad de sustituir la armadura pasiva por fibras metálicas o plásticas en cajones para obras portuarias. Para ello, en primer lugar, se estudia el procedimiento constructivo de un cajón y las propiedades de los hormigones con fibras. Una vez analizado el estado del conocimiento se procede a escoger un cajón representativo, ya construido con armadura pasiva. El cajón escogido es el cajón tipo 3 del dique est...

  7. Sensores de fibra óptica basados en resonancias electromagnéticas

    OpenAIRE

    López Lambás, Sergio

    2011-01-01

    Este trabajo surge como continuación a los trabajos basados en LMR ya realizados con el objetivo de profundizar en el estudio y fabricación de sensores de fibra óptica basados en resonancias electromagnéticas utilizando diferentes materiales y técnicas. En concreto el proyecto perseguirá los siguientes objetivos: Desarrollar sensores de fibra óptica basados en resonancias electromagnéticas con recubrimientos metálicos y su aplicación a la detección de campo magnético. Estudiar y mejorar la fa...

  8. Reconstrucción de lesiones osteocondrales con fibra de carbono

    OpenAIRE

    Carranza Bencano, A.; Armas-Padrón, J. R.; Lozano, Mª A.

    1998-01-01

    Objetivo: Estudiar a largo plazo la evolución histológica de defectos osteocondrales de la rótula de conejos tratados con fibra de carbono. Material y Método: 18 conejos de raza gigante español, variedad parda, de ambos sexos, con un peso aproximado de 1.5 a 2 Kg y 18 discos Cleveland de fibra de carbono de 8 mm de diámetro (Medicarb®, fabricado por Leyland Medical International). Creación de un defecto de 6 mm. de diámetro en la superficie articular de la rótula, hasta alcanzar el teji...

  9. Caracterización de propiedades relacionadas con la textura de suspensiones de fibras alimentarias

    OpenAIRE

    CÓRDOBA SEQUEIRA, ARTURO

    2008-01-01

    La fibra dietética es un componente que, además de ser beneficioso para la salud, puede resultar adecuado para aumentar la viscosidad y otras propiedades relacionadas de determinados productos. No obstante, la procedencia de la misma, así como su concentración y el modo en que se adicione puede afectar a su funcionalidad. En este trabajo se ha realizado un estudio de las propiedades físico-químicas y estructurales de fibras dietéticas procedentes de diferentes frutas (limón, naranja y manzana...

  10. Desenvolvimento de sorvete de chocolate utilizando fibra de casca de laranja como substituto de gordura

    Directory of Open Access Journals (Sweden)

    Camila Comas e Boff

    2013-10-01

    Full Text Available A procura por alimentos mais saudáveis por parte dos consumidores tem impulsionado as indústrias de alimentos a desenvolverem alimentos que contenham menor teor de gordura, contudo sem alterar as características sensoriais e nutricionais dos produtos. A indústria de sorvetes é uma das que mais utiliza gordura em suas formulações, contendo, em média, 10% desse ingrediente. Uma alternativa para a substituição de gorduras é a fibra de frutas cítricas, que vem sendo utilizada com sucesso, reduzindo o teor de gordura na indústria de embutidos, por exemplo. Nesse sentido, o objetivo deste trabalho foi avaliar as características sensoriais e físico-químicas de sorvetes elaborados com fibra de casca de laranja amarga comercial como substituto da gordura. Foram utilizadas duas formulações com concentrações diferentes de fibra de laranja (F1 com 0,74% e F2 com 1,10% de fibra e uma formulação controle (com gordura. Para as duas formulações, foram encontrados valores condizentes com a literatura para a composição centesimal do sorvete. Em relação ao valor energético dos sorvetes, foi observada uma redução de mais de 25%, indicando que o produto pode ter alegação de light. Para o teor de fibra dos sorvetes, os valores observados foram de F1 1,4% e F2, 2,0%, podendo considerar o sorvete da formulação F2 como fonte de fibras. Os atributos de cor, odor e textura não apresentaram diferenças entre as amostras. Já sabor, sabor residual e aceitação global obtiveram diferenças entre as amostras com fibra e a controle. Os sorvetes elaborados com fibra de casca de laranja obtiveram índices de aceitação de 78%.

  11. Dysphagia in facioscapulohumeral muscular dystrophy.

    NARCIS (Netherlands)

    Wohlgemuth, M.; Swart, B.J.M. de; Kalf, J.G.; Joosten, F.B.M.; Vliet, A.M. van der; Padberg, G.W.A.M.

    2006-01-01

    Dysphagia is not considered a symptom of facioscapulohumeral muscular dystrophy (FSHD). In this study, the authors found that dysphagia does occur in patients with advanced FSHD showing mild involvement of the jaw and lingual muscles. Dysphagia is seldom life threatening in these patients. The

  12. Glucocorticoids for Duchenne Muscular Dystrophy

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2013-07-01

    Full Text Available Investigators at the Dubowitz Neuromuscular Centre, Great Ormond Street Hospital, and other centers in the UK, conducted a prospective longitudinal study across 17 neuromuscular centers in the UK of 360 boys aged 3-15 years with Duchenne muscular dystrophy who were treated with daily or intermittent (10 days on/10 days off prednisolone for a mean duration of 4 years.

  13. BEEF CATTLE MUSCULARITY CANDIDATE GENES

    Directory of Open Access Journals (Sweden)

    Irida Novianti

    2010-04-01

    Full Text Available Muscularity is a potential indicator for the selection of more productive cattle. Mapping quantitative trait loci (QTL for traits related to muscularity is useful to identify the genomic regions where the genes affecting muscularity reside. QTL analysis from a Limousin-Jersey double backcross herd was conducted using QTL Express software with cohort and breed as the fixed effects. Nine QTL suggested to have an association with muscularity were identified on cattle chromosomes BTA 1, 2, 3, 4, 5, 8, 12, 14 and 17. The myostatin gene is located at the centromeric end of chromosome 2 and not surprisingly, the Limousin myostatin F94L variant accounted for the QTL on BTA2. However, when the myostatin F94L genotype was included as an additional fixed effect, the QTL on BTA17 was also no longer significant. This result suggests that there may be gene(s that have epistatic effects with myostatin located on cattle chromosome 17. Based on the position of the QTL in base pairs, all the genes that reside in the region were determined using the Ensembl data base (www.ensembl.org. There were two potential candidate genes residing within these QTL regions were selected. They were Smad nuclear interacting protein 1 (SNIP1 and similar to follistatin-like 5 (FSTL5. (JIIPB 2010 Vol 20 No 1: 1-10

  14. Inherited myopathies and muscular dystrophies

    NARCIS (Netherlands)

    Cardamone, Michael; Darras, Basil T.; Ryan, Monique M.

    The inherited myopathies and muscular dystrophies are a diverse group of muscle diseases presenting with common complaints and physical signs: weakness, motor delay, and respiratory and bulbar dysfunction. The myopathies are caused by genetic defects in the contractile apparatus of muscle, and

  15. Quantitative analysis of LISA pathfinder test-mass noise

    International Nuclear Information System (INIS)

    Ferraioli, Luigi; Congedo, Giuseppe; Hueller, Mauro; Vitale, Stefano; Hewitson, Martin; Nofrarias, Miquel; Armano, Michele

    2011-01-01

    LISA Pathfinder (LPF) is a mission aiming to test the critical technology for the forthcoming space-based gravitational-wave detectors. The main scientific objective of the LPF mission is to demonstrate test masses free falling with residual accelerations below 3x10 -14 m s -2 /√(Hz) at 1 mHz. Reaching such an ambitious target will require a significant amount of system optimization and characterization, which will in turn require accurate and quantitative noise analysis procedures. In this paper, we discuss two main problems associated with the analysis of the data from LPF: i) excess noise detection and ii) noise parameter identification. The mission is focused on the low-frequency region ([0.1, 10] mHz) of the available signal spectrum. In such a region, the signal is dominated by the force noise acting on test masses. At the same time, the mission duration is limited to 90 days and typical data segments will be 24 hours in length. Considering those constraints, noise analysis is expected to deal with a limited amount of non-Gaussian data, since the spectrum statistics will be far from Gaussian and the lowest available frequency is limited by the data length. In this paper, we analyze the details of the expected statistics for spectral data and develop two suitable excess noise estimators. One is based on the statistical properties of the integrated spectrum, the other is based on the Kolmogorov-Smirnov test. The sensitivity of the estimators is discussed theoretically for independent data, then the algorithms are tested on LPF synthetic data. The test on realistic LPF data allows the effect of spectral data correlations on the efficiency of the different noise excess estimators to be highlighted. It also reveals the versatility of the Kolmogorov-Smirnov approach, which can be adapted to provide reasonable results on correlated data from a modified version of the standard equations for the inversion of the test statistic. Closely related to excess noise

  16. Verification of time-delay interferometry techniques using the University of Florida LISA interferometry simulator

    Energy Technology Data Exchange (ETDEWEB)

    Mitryk, Shawn J; Wand, Vinzenz; Mueller, Guido, E-mail: smitryk@phys.ufl.ed, E-mail: mueller@phys.ufl.ed [Department of Physics, University of Florida, PO Box 118440, Gainesville, FL 32611-8440 (United States)

    2010-04-21

    Laser Interferometer Space Antenna (LISA) is a cooperative NASA/ESA mission proposed to directly measure gravitational waves (GW) in the frequency range from 30 muHz to 1 Hz with an optimal strain sensitivity of 10{sup -21}/sq root(Hz) at 3 mHz. LISA will utilize a modified Michelson interferometer to measure length changes of 40 pm/sq root(Hz) between drag-free proof masses located on three separate spacecraft (SC) separated by a distance of 5 Gm. The University of Florida has developed a hardware-in-the-loop simulator of the LISA constellation to verify the laser noise cancellation technique known as time-delay interferometry (TDI). We replicate the frequency stabilization of the laser on the local SC and the phase-locking of the lasers on the far SC. The laser photodetector beatnotes are electronically delayed, Doppler shifted and applied with a mock GW signal to simulate the laser link between the SC. The beatnotes are also measured with a LISA-like phasemeter and the data are used to extract the laser phase and residual phase-lock loop noise in post-processing through TDI. This uncovers the GW modulation signal buried under the laser noise. The results are then compared to the requirements defined by the LISA science collaboration.

  17. LISA Pathfinder test-mass charging during galactic cosmic-ray flux short-term variations

    Science.gov (United States)

    Grimani, C.; Fabi, M.; Lobo, A.; Mateos, I.; Telloni, D.

    2015-02-01

    Metal free-floating test masses aboard the future interferometers devoted to gravitational wave detection in space are charged by galactic and solar cosmic rays with energies \\gt 100 MeV/n. This process represents one of the main sources of noise in the lowest frequency band (\\lt 10-3 Hz) of these experiments. We study here the charging of the LISA Pathfinder (LISA-PF) gold-platinum test masses due to galactic cosmic-ray (GCR) protons and helium nuclei with the Fluka Monte Carlo toolkit. Projections of the energy spectra of GCRs during the LISA-PF operations in 2015 are considered. This work was carried out on the basis of the solar activity level and solar polarity epoch expected for LISA-PF. The effects of GCR short-term variations are evaluated here for the first time. Classical Forbush decreases, GCR variations induced by the Sun rotation, and fluctuations in the LISA-PF frequency bandwidth are discussed.

  18. Sensing and actuation system for the University of Florida Torsion Pendulum for LISA

    Science.gov (United States)

    Chilton, Andrew; Shelley, Ryan; Olatunde, Taiwo; Ciani, Giacomo; Conklin, John; Mueller, Guido

    2014-03-01

    Space-based gravitational wave detectors like LISA are a necessity for understanding the low-frequency portion of the gravitational universe. They use test masses (TMs) which are separated by Gm and are in free fall inside their respective spacecraft. Their relative distance is monitored with laser interferometry at the pm/rtHz level in the LISA band, ranging from 0.1 to 100 mHz. Each TM is enclosed in a housing that provides isolation, capacitive sensing, and electrostatic actuation capabilities. The electronics must both be sensitive at the 1 nm/rtHz level and not induce residual acceleration noise above the requirement for LISA Pathfinder (3*10-15 m/sec2Hz1/2at 3 mHz). Testing and developing this technology is one of the roles of the University of Florida Torsion Pendulum, the only US testbed for LISA-like gravitational reference sensor technology. Our implementation of the sensing system functions by biasing our hollow LISA-like TMs with a 100 kHz sine wave and coupling a pair surrounding electrodes as capacitors to a pair of preamps and a differential amplifier; all other processing is done digitally. Here we report on the design of, implementation of, and preliminary results from the UF Torsion Pendulum.

  19. CT findings of muscular dystrophy

    International Nuclear Information System (INIS)

    Saitoh, Hiroshi

    1991-01-01

    CT scans of muscles in patients with limb girdle type (LG), myotonic type (MYD) and Duchenne type (DMD) dystrophies were obtained at five different body levels: the neck, L3 vertebral body, pelvic girdle, thigh and lower leg. CT numbers, cross sectional areas (CSA) and %CSA of muscle or fat were evaluated in each muscle. The characteristic CT patterns for each type of muscular dystrophy were obtained. Compared with DMD, the gracilis and soleus were more severely damaged in LG and the biceps femoris remained relatively preserved among the hamstrings. In addition, the multifidus of the neck and sternocleidomastoid also were more severely damaged in MYD. This study suggests that CT scan will be useful in the differential diagnosis of these types of muscular dystrophy as well as in planning appropriate rehabilitation and detecting damaged muscles. (author)

  20. Fibra de sisal como envoltório na drenagem agrícola

    Directory of Open Access Journals (Sweden)

    Viviane F. Silva

    2014-06-01

    Full Text Available O trabalho foi realizado objetivando analisar o desempenho do sistema de drenagem com fibra de sisal envolto orgânico como material alternativo.  A pesquisa foi realizada no Laboratório de Engenharia de Irrigação e Drenagem da Universidade Federal de Campina Grande. Usando-se um sistema experimental composto de nove tanques construídos de alvenaria e impermeabilizados internamente. Os tratamentos foram dispostos em um arranjo fatorial com três tipos de tubos, Drenoflex, Kananet e tubo de PVC liso próprio para Esgoto envolto com fibra de sisal num delineamento inteiramente casualizado com três repetições. Foram avaliados a carga hidráulica de entrada (he, fluxo(q e resistência de entrada(re e analisados  estatisticamente, utilizando-se o software ASSISTAT . A comparação dos tubos Drenoflex, PVC liso e Kananet envolto com fibra de sisal, as médias da carga hidráulica na entrada para os tubos variando os valores de 0,40486 a 0,35543, sendo significativo para o tubo Kananet, devido possuir furos maiores facilitando assim a passagem da água pelo tubo. E em relação à resistência de entrada na interação entre os tubos drenantes e a fibra de sisal diferiu estatisticamente com o tubo PVC liso. O desempenho do sistema drenante com envolto de fibra de sisal é considerado muito bom.

  1. Fibras vegetales colombianas como refuerzo en compuestos de matriz polimérica

    Directory of Open Access Journals (Sweden)

    José Luis Suárez Castañeda

    2017-01-01

    Full Text Available Contexto: Se realizó una búsqueda local de tejidos de fibras vegetales para determinar la composición de los grupos funcionales y morfología de su superficie antes y después de un tratamiento alcalino con miras a su empleo como refuerzo en compuestos de matriz polimérica. Método: La búsqueda se desarrolló dentro del área metropolitana del Valle de Aburrá, Colombia. Las fibras se trataron por inmersión en NaOH disuelto al 6 % w/v por 48 horas, seguida por una neutralización en ácido acético al 1 % v/v por una hora. Posteriormente fueron secadas a 60 °C por 24 horas. Las técnicas empleadas para los análisis fueron la espectroscopía infrarroja por transformada de Fourier (FTIR y la microscopía electrónica de barrido (SEM. Resultados: Se seleccionaron tejidos de fique, yute, corteza de coco, lino y algodón. Los análisis FTIR muestran una tendencia a la disminución de ácidos grasos, hemicelulosas, ligninas y enlaces β en la superficie de las fibras, mientras que las imágenes SEM demuestran la remoción de impurezas, la exposición de rugosidades y la creación de espacios interfibrales. Conclusiones: El tratamiento alcalino podría favorecer el mecanismo de anclaje del polímero termofijo a la superficie de las fibras y la creación de enlaces entre las moléculas polares de las fibras y el polímero termofijo, disminuyendo el deslizamiento relativo entre matriz y refuerzo durante la aplicación de cargas.

  2. A Study of CAP-1002 in Ambulatory and Non-Ambulatory Patients With Duchenne Muscular Dystrophy

    Science.gov (United States)

    2018-04-17

    Muscular Dystrophies; Muscular Dystrophy, Duchenne; Muscular Disorders, Atrophic; Muscular Diseases; Neuromuscular Diseases; Nervous System Diseases; Genetic Diseases, X-Linked; Genetic Diseases, Inborn

  3. OBTENCIÓN DE FIBRA DIETETICA NUTRICIONAL DE VALOR AGREGADO A PARTIR DE BAGAZO DE CAÑA

    OpenAIRE

    LICONA AGUILAR, ANGELES IVETH

    2014-01-01

    La fibra dietética se reconoce cada vez más como un elemento importante para una nutrición sana; numerosas referencias respaldan esta aseveración en las que se ha demostrado no solo la importancia que la fibra tiene en la regulación de las funciones intestinales sino también para la prevención de algunas enfermedades. En este contexto, tiene sentido analizar la posibilidad de aprovechar la potencial utilización que brindan numerosos residuos agrícolas como fuente de fibra en una gran variedad...

  4. Reducing tilt-to-length coupling for the LISA test mass interferometer

    Science.gov (United States)

    Tröbs, M.; Schuster, S.; Lieser, M.; Zwetz, M.; Chwalla, M.; Danzmann, K.; Fernández Barránco, G.; Fitzsimons, E. D.; Gerberding, O.; Heinzel, G.; Killow, C. J.; Perreur-Lloyd, M.; Robertson, D. I.; Schwarze, T. S.; Wanner, G.; Ward, H.

    2018-05-01

    Objects sensed by laser interferometers are usually not stable in position or orientation. This angular instability can lead to a coupling of angular tilt to apparent longitudinal displacement—tilt-to-length coupling (TTL). In LISA this is a potential noise source for both the test mass interferometer and the long-arm interferometer. We have experimentally investigated TTL coupling in a setup representative for the LISA test mass interferometer and used this system to characterise two different imaging systems (a two-lens design and a four-lens design) both designed to minimise TTL coupling. We show that both imaging systems meet the LISA requirement of  ±25 μm rad‑1 for interfering beams with relative angles of up to  ±300 μrad. Furthermore, we found a dependency of the TTL coupling on beam properties such as the waist size and location, which we characterised both theoretically and experimentally.

  5. In-flight thermal experiments for LISA Pathfinder: Simulating temperature noise at the Inertial Sensors

    International Nuclear Information System (INIS)

    Armano, M; Audley, H; Born, M; Danzmann, K; Diepholz, I; Auger, G; Binetruy, P; Baird, J; Bortoluzzi, D; Brandt, N; Fitzsimons, E; Bursi, A; Caleno, M; Cavalleri, A; Cesarini, A; Dolesi, R; Ferroni, V; Cruise, M; Dunbar, N; Ferraioli, L

    2015-01-01

    Thermal Diagnostics experiments to be carried out on board LISA Pathfinder (LPF) will yield a detailed characterisation of how temperature fluctuations affect the LTP (LISA Technology Package) instrument performance, a crucial information for future space based gravitational wave detectors as the proposed eLISA. Amongst them, the study of temperature gradient fluctuations around the test masses of the Inertial Sensors will provide as well information regarding the contribution of the Brownian noise, which is expected to limit the LTP sensitivity at frequencies close to 1 mHz during some LTP experiments. In this paper we report on how these kind of Thermal Diagnostics experiments were simulated in the last LPF Simulation Campaign (November, 2013) involving all the LPF Data Analysis team and using an end-to-end simulator of the whole spacecraft. Such simulation campaign was conducted under the framework of the preparation for LPF operations. (paper)

  6. Advancements of the Lightweight Integrated Solar Array and Transceiver (LISA-T) Small Spacecraft System

    Science.gov (United States)

    Lockett, Tiffany Russell; Martinez, Armando; Boyd, Darren; SanSouice, Michael; Farmer, Brandon; Schneider, Todd; Laue, Greg; Fabisinski, Leo; Johnson, Les; Carr, John A.

    2015-01-01

    This paper describes recent advancements of the Lightweight Integrated Solar Array and Transceiver (LISA-T) currently being developed at NASA's Marshall Space Flight Center. The LISA-T array comprises a launch stowed, orbit deployed structure on which thin-film photovoltaic (PV) and antenna devices are embedded. The system provides significant electrical power generation at low weights, high stowage efficiency, and without the need for solar tracking. Leveraging high-volume terrestrial-market PVs also gives the potential for lower array costs. LISA-T is addressing the power starvation epidemic currently seen by many small-scale satellites while also enabling the application of deployable antenna arrays. Herein, an overview of the system and its applications are presented alongside sub-system development progress and environmental testing plans.

  7. The Mock LISA Data Challenges: from challenge 3 to challenge 4

    International Nuclear Information System (INIS)

    Babak, Stanislav; Petiteau, Antoine; Robinson, Emma L; Baker, John G; McWilliams, Sean T; Arnaud, Keith A; Benacquista, Matthew J; Cornish, Neil J; Adams, Matt; Larson, Shane L; Mandel, Ilya; Porter, Edward K; Vallisneri, Michele; Cutler, Curt; Vecchio, Alberto; Blaut, Arkadiusz; Bridges, Michael; Feroz, Farhan; Cohen, Michael; Gair, Jonathan R.

    2010-01-01

    The Mock LISA Data Challenges are a program to demonstrate LISA data-analysis capabilities and to encourage their development. Each round of challenges consists of one or more datasets containing simulated instrument noise and gravitational waves from sources of undisclosed parameters. Participants analyze the datasets and report best-fit solutions for the source parameters. Here we present the results of the third challenge, issued in April 2008, which demonstrated the positive recovery of signals from chirping galactic binaries, from spinning supermassive-black-hole binaries (with optimal SNRs between ∼10 and 2000), from simultaneous extreme-mass-ratio inspirals (SNRs of 10-50), from cosmic-string-cusp bursts (SNRs of 10-100), and from a relatively loud isotropic background with Ω gw (f) ∼ 10 -11 , slightly below the LISA instrument noise.

  8. The Mock LISA Data Challenges: from challenge 3 to challenge 4

    Energy Technology Data Exchange (ETDEWEB)

    Babak, Stanislav; Petiteau, Antoine; Robinson, Emma L [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut), Am Muehlenberg 1, D-14476 Golm bei Potsdam (Germany); Baker, John G; McWilliams, Sean T; Arnaud, Keith A [Gravitational Astrophysics Laboratory, NASA Goddard Space Flight Center, 8800 Greenbelt Rd, Greenbelt, MD 20771 (United States); Benacquista, Matthew J [Center for Gravitational Wave Astronomy, University of Texas at Brownsville, Brownsville, TX 78520 (United States); Cornish, Neil J; Adams, Matt [Department of Physics, Montana State University, Bozeman, MT 59717 (United States); Larson, Shane L [Department of Physics, Utah State University, Logan, UT 84322 (United States); Mandel, Ilya [Department of Physics and Astronomy, Northwestern University, Evanston, IL (United States); Porter, Edward K [APC, UMR 7164, University Paris 7 Denis Diderot, 10, rue Alice Domon et Leonie Duquet, 75025 Paris Cedex 13 (France); Vallisneri, Michele; Cutler, Curt [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States); Vecchio, Alberto [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B152TT (United Kingdom); Blaut, Arkadiusz [Institute of Theoretical Physics, University of Wroclaw, Wroclaw (Poland); Bridges, Michael; Feroz, Farhan [Astrophysics Group, Cavendish Laboratory, University of Cambridge, Cambridge CB30HE (United Kingdom); Cohen, Michael [Theoretical Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Gair, Jonathan R., E-mail: Michele.Vallisneri@jpl.nasa.go [Institute of Astronomy, University of Cambridge, Cambridge CB30HA (United Kingdom)

    2010-04-21

    The Mock LISA Data Challenges are a program to demonstrate LISA data-analysis capabilities and to encourage their development. Each round of challenges consists of one or more datasets containing simulated instrument noise and gravitational waves from sources of undisclosed parameters. Participants analyze the datasets and report best-fit solutions for the source parameters. Here we present the results of the third challenge, issued in April 2008, which demonstrated the positive recovery of signals from chirping galactic binaries, from spinning supermassive-black-hole binaries (with optimal SNRs between approx10 and 2000), from simultaneous extreme-mass-ratio inspirals (SNRs of 10-50), from cosmic-string-cusp bursts (SNRs of 10-100), and from a relatively loud isotropic background with OMEGA{sub gw}(f) approx 10{sup -11}, slightly below the LISA instrument noise.

  9. LISA technologies in new light: exploring alternatives for charge management and optical bench construction

    Science.gov (United States)

    Ciani, Giacomo; Chilton, Andrew; Olatunde, Taiwo; Apple, Stephen; Conklin, John W.; Mueller, Guido

    2015-08-01

    A LISA-like gravitational wave observatory is the choice candidate for ESA's L3 large mission scheduled to launch in 2034. The LISA Test Package (LTP) mission will launch later this year and test many critical technologies needed for such an observatory, among which are picometer interferometry in space and UV charge management of the Test Mass (TM). The design of these subsystems has been frozen many years ago during the final formulation of the LTP mission; since then, the LISA mission concept has evolved and new technologies have become available, making it possible to re-think the way these subsystem are implemented. With the final formulation of the L3 mission still years in the future and the LTP results expected in about one year, now is an ideal time look for areas of possible improvement and explore alternative implementations that can enhance performance, reduce costs or mitigate risks.Recently developed UV LED are lighter, cheaper and more powerful than traditional mercury lamps; in addition, their fast response time can be used to implement AC discharge techniques that can save even more space and power, and provide a more precise control of the charge.The most recent iteration of the mission baseline design allows for eliminating some of the optical components initially deemed essential; paired with the use of polarization multiplexing, this permits a redesign of the optical bench that simplifies the layout and enables a modular approach to machining and assembly, thus reducing the risks and costs associated with the current monolithic design without compromising the picometer stability of the optical path.Leveraging on extensive previous experience with LISA interferometry and the availability of a torsion pendulum-based LISA test-bed, the University of Florida LISA group is working at developing, demonstrating and optimizing both these technologies. I will describe the most recent advancements and results.

  10. MONA, LISA and VINCI Soon Ready to Travel to Paranal

    Science.gov (United States)

    2000-11-01

    First Instruments for the VLT Interferometer Summary A few months from now, light from celestial objects will be directed for the first time towards ESO's Very Large Telescope Interferometer (VLTI) at the Paranal Observatory (Chile). During this "First Light" event and the subsequent test phase, the light will be recorded with a special test instrument, VINCI (VLT INterferometer Commissioning Instrument). The main components of this high-tech instrument are aptly named MONA (a system that combines the light beams from several telescopes by means of optical fibers) and LISA (the infrared camera). VINCI was designed and constructed within a fruitful collaboration between ESO and several research institutes and industrial companies in France and Germany . It is now being assembled at the ESO Headquarters in Garching (Germany) and will soon be ready for installation at the telescope on Paranal. With the VLTI and VINCI, Europe's astronomers are now entering the first, crucial phase of an exciting scientific and technology venture that will ultimately put the world's most powerful optical/IR interferometric facility in their hands . PR Photo 31/00 : VINCI during tests at the ESO Headquarters in Garching. The VLT Interferometer (VLTI) ESO Press Photo 31/00 ESO Press Photo 31/00 [Preview; JPEG: 400 x 301; 43k] [Normal; JPEG: 800 x 602;208xk] [Full-Res; JPEG: 1923 x 1448; 2.2Mb] PR Photo 31/00 shows the various components of the complex VINCI instrument for the VLT Interferometer , during the current tests at the Optical Laboratory at the ESO Headquarters in Garching (Germany). It will later be installed in "clean-room" conditions within the Interferometric Laboratory at the Paranal Observatory. This electronic photo was obtained for documentary purposes. VINCI (VLT INterferometer Commissioning Instrument) is the "First Light" instrument for the Very Large Telescope Interferometer (VLTI) at the Paranal Observatory (Chile). Early in 2001, it will be used for the first tests

  11. LTP - LISA technology package: Development challenges of a spaceborne fundamental physics experiment

    International Nuclear Information System (INIS)

    Gerndt, R

    2009-01-01

    The LISA Technology Package (LTP) is the main payload onboard the LISA Pathfinder Spacecraft. The LTP Instrument together with the Drag-Free Attitude Control System (DFACS) and the respective LTP and DFACS operational software forms the LTP Experiment. It is completed by the FEEPs of the LPF spacecraft that are controlled by DFACS in order to control the spacecraft's attitude along with the experiment's needs. This article concentrates on aspects of the Industrial development of the LTP Instrument items and on essential performance issues of LTP. Examples of investigations on specific issue will highlight the kind of special problems to be solved for LTP in close cooperation with the Scientific Community.

  12. Acoustic waves and the detectability of first-order phase transitions by eLISA

    Science.gov (United States)

    Weir, David J.

    2017-05-01

    In various extensions of the Standard Model it is possible that the electroweak phase transition was first order. This would have been a violent process, involving the formation of bubbles and associated shock waves. Not only would the collision of these bubbles and shock waves be a detectable source of gravitational waves, but persistent acoustic waves could enhance the signal and improve prospects of detection by eLISA. I summarise the results of a recent campaign to model such a phase transition based on large-scale hydrodynamical simulations, and its implications for the eLISA mission.

  13. From LPF to eLISA: new approach in payload software

    Science.gov (United States)

    Gesa, Ll.; Martin, V.; Conchillo, A.; Ortega, J. A.; Mateos, I.; Torrents, A.; Lopez-Zaragoza, J. P.; Rivas, F.; Lloro, I.; Nofrarias, M.; Sopuerta, CF.

    2017-05-01

    eLISA will be the first observatory in space to explore the Gravitational Universe. It will gather revolutionary information about the dark universe. This implies a robust and reliable embedded control software and hardware working together. With the lessons learnt with the LISA Pathfinder payload software as baseline, we will introduce in this short article the key concepts and new approaches that our group is working on in terms of software: multiprocessor, self-modifying-code strategies, 100% hardware and software monitoring, embedded scripting, Time and Space Partition among others.

  14. Doing Science with eLISA: Astrophysics and Cosmology in the Millihertz Regime

    Science.gov (United States)

    Amaro, Seoane, Pau; Aoudia, Sofiane; Babak, Stanislav; Binetruy, Pierre; Berti, Amanuele; Bohe, Alejandro; Caprini, Chiara; Colpi, Monica; Cornish, Neil J.; Danzmann, Karsten; hide

    2012-01-01

    This document introduces the exciting and fundamentally new science and astronomy that the European New Gravitational Wave Observatory (NGO) mission (derived from the previous LISA proposal) will deliver. The mission (which we will refer to by its informal name eLISA ) will survey for the first time the low-frequency gravitational wave band (about 0.1 mHz to 1 Hz), with sufficient sensitivity to detect interesting individual astrophysical sources out to z = 15. The measurements described here will address the basic scientific goals that have been captured in ESA s New Gravitational Wave Observatory Science Requirements Document ; they are presented here so that the wider scientific community can have access to them. The eLISA mission will discover and study a variety of cosmic events and systems with high sensitivity: coalescences of massive black holes binaries, brought together by galaxy mergers; mergers of earlier, less-massive black holes during the epoch of hierarchical galaxy and black-hole growth; stellar-mass black holes and compact stars in orbits just skimming the horizons of massive black holes in galactic nuclei of the present era; extremely compact white dwarf binaries in our Galaxy, a rich source of information about binary evolution and about future Type Ia supernovae; and possibly most interesting of all, the uncertain and unpredicted sources, for example relics of inflation and of the symmetry-breaking epoch directly after the Big Bang. eLISA s measurements will allow detailed studies of these signals with high signal-to-noise ratio, addressing most of the key scientific questions raised by ESA s Cosmic Vision programme in the areas of astrophysics and cosmology. They will also provide stringent tests of general relativity in the strong-field dynamical regime, which cannot be probed in any other way. This document not only describes the science but also gives an overview on the mission design and orbits. LISA s heritage in the eLISA design will be

  15. eLISA eccentricity measurements as tracers of binary black hole formation

    OpenAIRE

    Nishizawa, Atsushi; Berti, Emanuele; Klein, Antoine; Sesana, Alberto

    2016-01-01

    Up to hundreds of black hole binaries individually resolvable by eLISA will coalesce in the Advanced LIGO/Virgo band within ten years, allowing for multi-band gravitational wave observations. Binaries formed via dynamical interactions in dense star clusters are expected to have eccentricities $e_0\\sim 10^{-3}$-$10^{-1}$ at the frequencies $f_0=10^{-2}$ Hz where eLISA is most sensitive, while binaries formed in the field should have negligible eccentricity in both frequency bands. We estimate ...

  16. Lesiones musculares en el deporte. Muscular injuries in sport.

    Directory of Open Access Journals (Sweden)

    Jiménez Díaz, José Fernando

    2006-04-01

    Full Text Available ResumenDurante la práctica de la actividad física hay una gran incidencia de lesiones musculares, si bien se han llevado a cabo pocos estudios clínicos sobre el tratamiento y la resolución de las mismas. Desde el punto de vista etiopatogénico, hay que señalar que la incidencia de lesión es mayor en aquellos músculos poliarticulares en condiciones de acumulación de fatiga y con condiciones ambientales desfavorables. La clasificación de las lesiones musculares permite distinguir entre aquellas que no afectan a la fascia produciéndose un sangrado dentro del mismo (intramuscular o bien si la fascia también se rompe, el sangrado se sitúa entre los diferentes músculos (intermuscular. El tratamiento de estas lesiones se realizará combinando reposo, compresión, aplicación de frío y elevación del área lesionada así como el desarrollo de un adecuado programa de readaptación funcional que permita al jugador incorporarse lo antes posible a la dinámica del equipo. En la actualidad se está llevando a cabo opciones terapéuticas con factores de crecimiento, terapia génica y células madre, si bien todavía no están lo suficientemente desarrolladas.AbstractDuring the practice of the physical activity there is a great effect of muscular injuries, though few clinical studies have been carried out on the treatment and the resolution of the same ones. Inside the reasons it is necessary to indicate that the effect of injury is major in those muscles you will polyarticulate in situation of fatigue and with environmental unfavorable conditions.The classification of the muscular injuries allows to distinguish between those that do not affect the fascia producing the bled intramuscular or if the fascia also breaks, the bled one places between the different muscles (intermuscular.The treatment will be realized combining rest, compression, application of cold and elevation of these injuries as well as the development of a program of functional

  17. El Nopal fresco como fuente de fibra y calcio en panqués El Nopal fresco como fuente de fibra y calcio en panqués

    OpenAIRE

    José Eleazar Barboza- Corona; Victor Manuel Da Mota; Ernesto Camarena-Aguilar; Guadalupe Alanís- Guzmán; Rosa Inés Pineda Torres; Mayela Bautista-Justo

    2012-01-01

    El objetivo de este trabajo fue utilizar nopal fresco en la formulación de panqués para incrementar su contenido de fibra dietética y calcio. Se desarrollaron cinco formulaciones de panqués utilizando nopal fresco (Opuntia amyclaea Tenore), 4 con sucralosa (una testigo sin nopal) y una con azúcar y nopal. Se evaluaron sensorialmente por 60 jueces no entrenados mediante la prueba de preferencia, utilizando una escala hedónica del 1 al 9. Se les determinó el contenido de proteína (Nx6.25), hume...

  18. Muscular Calf Injuries in Runners.

    Science.gov (United States)

    Fields, Karl B; Rigby, Michael D

    2016-01-01

    Calf pain is a common complaint among runners of all ages but is most frequent in masters athletes. This article focuses on injuries to the triceps surae or true 'calf muscles.' The most common calf injury is a tear of the medial gastrocnemius muscle (Tennis Leg) but other structures including the lateral gastrocnemius, plantaris and soleus also may be the cause of muscular pain. This article looks at the presentation, evaluation, and treatment of these injuries. We also highlight some examples of musculoskeletal ultrasound which is a valuable tool for rapid diagnosis of the cause and extent of injury.

  19. Genetics Home Reference: Duchenne and Becker muscular dystrophy

    Science.gov (United States)

    ... Conditions Duchenne and Becker muscular dystrophy Duchenne and Becker muscular dystrophy Printable PDF Open All Close All Enable Javascript ... dystrophy occur almost exclusively in males. Duchenne and Becker muscular dystrophies have similar signs and symptoms and are caused ...

  20. Sky Localization of Complete Inspiral-Merger-Ringdown Signals for Nonspinning Black Hole Binaries with LISA

    Science.gov (United States)

    McWilliams, Sean T.; Lang, Ryan N.; Baker, John G.; Thorpe, James Ira

    2011-01-01

    We investigate the capability of LISA to measure the sky position of equal-mass, nonspinning black hole binaries, including for the first time the entire inspiral-merger-ringdown signal, the effect of the LISA orbits, and the complete three-channel LISA response. For an ensemble of systems near the peak of LISA's sensitivity band, with total rest mass of 2 x l0(exp 6) Stellar Mass at a redshift of z = 1 with random orientations and sky positions, we find median sky localization errors of approximately approx. 3 arcminutes. This is comparable to the field of view of powerful electromagnetic telescopes, such as the James Webb Space Telescope, that could be used to search for electromagnetic signals associated with merging black holes. We investigate the way in which parameter errors decrease with measurement time, focusing specifically on the additional information provided during the merger-ringdown segment of the signal. We find that this information improves all parameter estimates directly, rather than through diminishing correlations with any subset of well-determined parameters.

  1. Estudo bibliométrico do descritor “Ergonomia” na base LISA

    Directory of Open Access Journals (Sweden)

    Eliana Maria dos Santos Bahia

    2011-03-01

    Full Text Available Objetivo: O estudo analisa a produção científica sobre ergonomia utilizando a base de dados Library and Information Science Abstracts (LISA. A base de dados LISA, iniciada em 1969, mantém sua cobertura temática na área de Biblioteconomia e Ciência da Informação.Método: No estudo utilizou-se o método da bibliometria aplicada para verificar a produção científica indexada.Resultados: Entre os resultados da busca de termos indexados na base de dados LISA, encontraram-se 503 artigos com o termo “Ergonomic”; 352 artigos, com a expressão “Design”; 111 artigos com o descritor “Systems”; 110 artigos com o termo “Work”; e , 98 artigos com o termo “Evaluation”. Dentre os 34 títulos de periódicos, 4 títulos cobrem 79% dos artigos que tratam sobre Ergonomia na base LISA. Os demais 30 títulos de periódicos cobrem 21% dos artigos indexados sob essa temática.Conclusões: O presente estudo bibliométrico oferece possibilita um panorama de como a ergonomia é percebida na área da Biblioteconomia e Ciência da Informação.

  2. LISA detection of massive black hole binaries: imprint of seed populations and extreme recoils

    International Nuclear Information System (INIS)

    Sesana, A; Volonteri, M; Haardt, F

    2009-01-01

    All the physical processes involved in the formation, merging and accretion history of massive black holes along the hierarchical build-up of cosmic structures are likely to leave an imprint on the gravitational waves detectable by future space-borne missions, such as LISA. We report here the results of recent studies, carried out by means of dedicated simulations of black hole build-up, aiming at understanding the impact on LISA observations of two ingredients that are crucial in every massive black hole formation scenario, namely: (i) the nature and abundance of the first black hole seeds and (ii) the large gravitational recoils following the merger of highly spinning black holes. We predict LISA detection rates spanning two orders of magnitude, in the range 3-300 events per year, depending on the detail of the assumed massive black hole seed model. On the other hand, large recoil velocities do not dramatically compromise the efficiency of LISA observations. The number of detections may drop substantially (by ∼60%), in scenarios characterized by abundant light seeds, but if seeds are already massive and/or relatively rare, the detection rate is basically unaffected.

  3. Numerical code to determine the particle trapping region in the LISA machine

    International Nuclear Information System (INIS)

    Azevedo, M.T. de; Raposo, C.C. de; Tomimura, A.

    1984-01-01

    A numerical code is constructed to determine the trapping region in machine like LISA. The variable magnetic field is two deimensional and is coupled to the Runge-Kutta through the Tchebichev polynomial. Various particle orbits including particle interactions were analysed. Beside this, a strong electric field is introduced to see the possible effects happening inside the plasma. (Author) [pt

  4. Interpolation of the magnetic field at the test masses in eLISA

    International Nuclear Information System (INIS)

    Mateos, I; Díaz-Aguiló, M; Ramos-Castro, J; García-Berro, E; Lobo, A

    2015-01-01

    A feasible design for a magnetic diagnostics subsystem for eLISA will be based on that of its precursor mission, LISA Pathfinder. Previous experience indicates that magnetic field estimation at the positions of the test masses has certain complications. This is due to two reasons. The first is that magnetometers usually back-act due to their measurement principles (i.e., they also create their own magnetic fields), while the second is that the sensors selected for LISA Pathfinder have a large size, which conflicts with space resolution and with the possibility of having a sufficient number of them to properly map the magnetic field around the test masses. However, high-sensitivity and small-sized sensors that significantly mitigate the two aforementioned limitations exist, and have been proposed to overcome these problems. Thus, these sensors will be likely selected for the magnetic diagnostics subsystem of eLISA. Here we perform a quantitative analysis of the new magnetic subsystem, as it is currently conceived, and assess the feasibility of selecting these sensors in the final configuration of the magnetic diagnostic subsystem. (paper)

  5. Modulation of LISA free-fall orbits due to the Earth-Moon system

    Energy Technology Data Exchange (ETDEWEB)

    Cerdonio, Massimo; Marzari, Francesco [Department of Physics, University of Padova and INFN Padova, via Marzolo 8, I-35131 Padova (Italy); De Marchi, Fabrizio [Department of Physics, University of Trento and INFN Trento, I-38100 Povo (Trento) (Italy); De Pietri, Roberto [Department of Physics, University of Parma and INFN Parma I-43100 Parma (Italy); Jetzer, Philippe [Institute of Theoretical Physics, University of Zuerich, Winterhurerstrasse 190, 8057 Zuerich (Switzerland); Mazzolo, Giulio [Max Planck Institut fuer Gravitationsphysik, Callinstrasse 38, 30167 Hannover (Germany); Ortolan, Antonello [INFN Laboratori Nazionali di Legnaro, Viale dell' Universita 35020 Legnaro (Padova) (Italy); Sereno, Mauro, E-mail: fdemarchi@science.unitn.i [Dipartimento di Fisica, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino (Italy)

    2010-08-21

    We calculate the effect of the Earth-Moon (EM) system on the free-fall motion of LISA test masses. We show that the periodic gravitational pulling of the EM system induces a resonance with fundamental frequency 1 yr{sup -1} and a series of periodic perturbations with frequencies equal to integer harmonics of the synodic month ({approx_equal} 3.92 x 10{sup -7} Hz). We then evaluate the effects of these perturbations (up to the 6th harmonics) on the relative motions between each test mass couple, finding that they range between 3 mm and 10 pm for the 2nd and 6th harmonic, respectively. If we take the LISA sensitivity curve, as extrapolated down to 10{sup -6} Hz in Bender (2003 Class. Quantum Grav. 20 301-10), we obtain that a few harmonics of the EM system can be detected in the Doppler data collected by the LISA space mission. This suggests that the EM system gravitational near field could provide an additional crosscheck to the calibration of LISA, as extended to such low frequencies.

  6. Modulation of LISA free-fall orbits due to the Earth-Moon system

    International Nuclear Information System (INIS)

    Cerdonio, Massimo; Marzari, Francesco; De Marchi, Fabrizio; De Pietri, Roberto; Jetzer, Philippe; Mazzolo, Giulio; Ortolan, Antonello; Sereno, Mauro

    2010-01-01

    We calculate the effect of the Earth-Moon (EM) system on the free-fall motion of LISA test masses. We show that the periodic gravitational pulling of the EM system induces a resonance with fundamental frequency 1 yr -1 and a series of periodic perturbations with frequencies equal to integer harmonics of the synodic month (≅ 3.92 x 10 -7 Hz). We then evaluate the effects of these perturbations (up to the 6th harmonics) on the relative motions between each test mass couple, finding that they range between 3 mm and 10 pm for the 2nd and 6th harmonic, respectively. If we take the LISA sensitivity curve, as extrapolated down to 10 -6 Hz in Bender (2003 Class. Quantum Grav. 20 301-10), we obtain that a few harmonics of the EM system can be detected in the Doppler data collected by the LISA space mission. This suggests that the EM system gravitational near field could provide an additional crosscheck to the calibration of LISA, as extended to such low frequencies.

  7. Playing Harry Potter: Essays and interviews on fandom and performance, edited by Lisa S. Brenner

    Directory of Open Access Journals (Sweden)

    Abigail De Kosnik

    2016-09-01

    Full Text Available Lisa S. Brenner, editor. Playing Harry Potter: Essays and interviews on fandom and performance. Jefferson, NC: McFarland, 2015, paperback, $29.95 (238p ISBN 978-0-7864-9657-0; e-book $14.43 (5374 KB ISBN 978-1-4766-2136-4, ASIN B012E9G0R6.

  8. PREFACE: Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008

    Science.gov (United States)

    Lobo, Alberto; Sopuerta, Carlos F.

    2009-07-01

    In June 2006 the LISA International Science Team (LIST) accepted the bid presented by the Institut d'Estudis Espacials de Catalunya (IEEC) to host the 7th International LISA Symposium. This was during its 11th meeting at the University of Maryland, just before the 6th edition of the Symposium started in NASA's Goddard Space Flight Center. The 7th International LISA Symposium took place at the city of Barcelona, Spain, from 16-20 June 2008, in the premises of CosmoCaixa, a modern Science Museum located in the hills near Tibidabo. Almost 240 delegates registered for the event, a record breaking figure compared to previous editions of the Symposium. Many of the most renowned world experts in LISA, Gravitational Wave Science, and Astronomy, as well as Engineers, attended LISA 7 and produced state-of-the-art presentations, while everybody benefited from the opportunity to have live discussions during the week in a friendly environment. The programme included 31 invited plenary lectures in the mornings, and 8 parallel sessions in the afternoons. These were classified into 7 major areas of research: LISA Technology, LISA PathFinder, LISA PathFinder Data Analysis, LISA Data Analysis, Gravitational Wave sources, Cosmology and Fundamental Physics with LISA and Other Gravitational Wave Detectors. 138 abstracts for communications were received, of which a selection was made by the session convenors which would fit time constraints. Up to 63 posters completed the scientific programme. More details on the programme, including some of the talks, can be found at the Symposium website: http://www.ice.cat/research/LISA_Symposium. There was however a remarkable add-on: Professor Clifford Will delivered a startling presentation to the general public, who completely filled the Auditori—the main Conference Room, 320 seats—and were invited to ask questions to the speaker who had boldly guided them through the daunting world of Black Holes, Waves of Gravity, and other Warped Ideas of

  9. Massive black-hole binary inspirals: results from the LISA parameter estimation taskforce

    International Nuclear Information System (INIS)

    Arun, K G; Babak, Stas; Porter, Edward K; Sintes, Alicia M; Berti, Emanuele; Cutler, Curt; Cornish, Neil; Gair, Jonathan; Hughes, Scott A; Lang, Ryan N; Iyer, Bala R; Sinha, Siddhartha; Mandel, Ilya; Sathyaprakash, Bangalore S; Van Den Broeck, Chris; Trias, Miquel; Volonteri, Marta

    2009-01-01

    The LISA Parameter Estimation Taskforce was formed in September 2007 to provide the LISA Project with vetted codes, source distribution models and results related to parameter estimation. The Taskforce's goal is to be able to quickly calculate the impact of any mission design changes on LISA's science capabilities, based on reasonable estimates of the distribution of astrophysical sources in the universe. This paper describes our Taskforce's work on massive black-hole binaries (MBHBs). Given present uncertainties in the formation history of MBHBs, we adopt four different population models, based on (i) whether the initial black-hole seeds are small or large and (ii) whether accretion is efficient or inefficient at spinning up the holes. We compare four largely independent codes for calculating LISA's parameter-estimation capabilities. All codes are based on the Fisher-matrix approximation, but in the past they used somewhat different signal models, source parametrizations and noise curves. We show that once these differences are removed, the four codes give results in extremely close agreement with each other. Using a code that includes both spin precession and higher harmonics in the gravitational-wave signal, we carry out Monte Carlo simulations and determine the number of events that can be detected and accurately localized in our four population models.

  10. Uso de fibra natural de sisal em blocos de concreto para alvenaria estrutural

    OpenAIRE

    Indara Soto Izquierdo

    2011-01-01

    A utilização de fibras vegetais como reforço constitui um grande interesse na obtenção de novos materiais para a construção civil produto de seu baixo custo, alta disponibilidade e reduzido consumo de energia para sua produção. Este trabalho avalia a incorporação de fibras de sisal, de comprimento 20 e 40 mm, e fração volumétrica de 0,5 e 1%, em concretos para a alvenaria de blocos estruturais e determina o uso destas unidades na execução de prismas e mini-paredes. Foram realizados os testes ...

  11. Perfis de polietileno reciclado carregado com fibra de açaí

    OpenAIRE

    BRITO, Paulo Roberto de Oliveira

    2012-01-01

    Foram obtidos perfis tubulares porosos de polietileno (PE) e de polietileno/fibra de açaí (PE/PA) 80/20 extrudados a partir de partículas granuladas de polietileno de alta densidade reciclado de embalagens pós-consumo de 600 μm, e deste com fibra de açaí de 300 μm. Para o processamento das peças foi desenvolvida uma extrusora mono-rosca de bancada, com sistema mecânico acionado por um motor elétrico de ½ CV (0,37 kw) controlado por um inversor de freqüência, com canhões, roscas, matriz e sist...

  12. Vibrómetro de fibra óptica codificado en frecuencia

    OpenAIRE

    Sánchez Prudencio, Guillermo

    2013-01-01

    En el presente proyecto se expone el desarrollo de un vibrómetro basado en fibra óptica. La motivación de este proyecto es el diseño de un sistema capaz de monitorizar las vibraciones de una máquina mediante el uso de tecnología láser y de fibra óptica. Mediante este sistema es posible el cálculo de la frecuencia y amplitud de la vibración de la máquina. El vibrómetro está basado en el principio de interferencia de la luz. Un haz de luz coherente proporcionado por un láser se divide en dos: u...

  13. TECNOLOGIA A FIBRA OPTICA: UNIVERSIDAD NACIONAL DE COLOMBIA SEDE MEDELLIN, "UN REFERENTE LATINOAMERICANO"

    Directory of Open Access Journals (Sweden)

    RODRIGO ACUÑA

    2008-01-01

    Full Text Available En este artículo se muestran algunos resultados de las investigaciones realizadas por el grupo de Fotónica y Opto-electrónica de la Universidad Nacional de Colombia, Sede Medellín. Se hace una breve reseña de la creación del grupo y se describen las principales aplicaciones desarrolladas, las cuales convierten al grupo en un referente Latinoamericano en el área. Se ilustran aplicaciones de las redes de Bragg en fibra óptica en sensores, simulaciones computacionales de guías de onda ópticas y la construcción de fuentes de luz láser a fibra óptica.

  14. Fibra da casca do coco verde como substrato agrícola

    Directory of Open Access Journals (Sweden)

    Carrijo Osmar Alves

    2002-01-01

    Full Text Available A produção comercial de mudas e o cultivo sem solo de hortaliças estão se tornando práticas comuns entre os olericultores. Vários materiais orgânicos como as turfas, resíduos de madeira, casca de pinus e de arroz parcialmente carbonizada ou não, ou materiais inorgânicos como areia, rochas vulcânicas, perlita, lã de rocha e a espuma fenólica já são utilizados como substratos, isoladamente ou em composição. A casca de coco verde que em muitas regiões causa transtorno ao serviço de limpeza pública pelo volume e pela dificuldade de decomposição produz uma fibra que pode ser utilizada como substrato. Para a produção da fibra, a casca de coco verde é picada, desfibrada, triturada, lavada e secada. Para o uso como substrato na produção de mudas, a fibra deve passar por um processo de compostagem. Este processo não é necessário para o uso como substrato em cultivo sem solo, mas no entanto, o substrato necessitará ser enriquecido com nutrientes em pré-plantio ou em fertirrigação. O uso do substrato da fibra de coco verde na produção de tomate em casa de vegetação, alcançou, em termos absolutos, 13,2 kg m-2 de frutos comerciais (média de 3 anos cerca de 7,3% mais que o segundo melhor substrato, o pó de serra com 12,3 kg m-2.

  15. PROPRIEDADES TERMOFÍSICAS DE COMPÓSITO DE MATRIZ DE GESSO E FIBRA VEGETAL

    Directory of Open Access Journals (Sweden)

    George Santos Marinho

    2013-03-01

    Full Text Available Foi desenvolvido um compósito de matriz de gesso e reforço de fibra vegetal (Cocos nucifera destinado à fabricação de elementos construtivos (e. g., placas para forração de coberturas e painéis de vedação. Corpos de prova foram produzidos na forma de sanduíche de gesso / fibra / gesso. Duas espessuras diferentes da fatia de fibra foram consideradas: 8 mm e 10 mm. Um corpo de prova de gesso sem a fatia de fibra foi fabricado para servir como padrão de comparação. Utilizando-se um equipamento analisador térmico, foram realizados ensaios para determinação das seguintes propriedades termofísicas dos corpos de prova: condutividade térmica (k, capacidade térmica volumétrica (.CP e difusividade térmica (. A partir dos resultados foi possível evidenciar vantagens do compósito em relação ao padrão. O menor valor de k conferiu ao compósito uma maior capacidade de isolação, possibilitando redução da carga térmica no interior das edificações devido à radiação solar. Nsse aspecto, o compósito se mostra adequado ao uso como elemento de vedação em edificações situadas em localidades de baixas latitudes (e. g., região Nordeste do Brasil. Além das vantagens citadas, o compósito pode proporcionar mais leveza e economia de material, possibilitando a produção de elementos construtivos mais esbeltos.

  16. Miopatia por deficiência de carnitina-palmitil-transferase: relato de 2 casos com dosagens enzimáticas no tecido muscular

    Directory of Open Access Journals (Sweden)

    Lineu Cesar Werneck

    1983-12-01

    Full Text Available Relato dos casos de dois irmãos, que desde a infância apresentavam dores musculares após exercício prolongado ou exposição ao frio, com diminuição da força, à medida que o exercício continuava. Um deles desenvolveu mioglobinúria recorrente e, em um episódio apresentou insuficiência renal aguda, necessitando de diálise peritonial. A investigação laboratorial intercrise foi normal, mas durante o episódio de mioglobinúria, apresentou grande aumento da creatinafosfoquinase. A eletromiografia foi sugestiva de processo de denervação. Teste de produção de lactato durante isquemia foi normal. Biópsias musculares mostraram discreto aumento dos lipídios nas fibras musculares e maior atividade da desidrogenase succínica na histoquímica. O estudo bioquímico do tecido muscular dos dois pacientes, revelou importante redução da atividade da carnitina-palmitil-transferase, com atividade normal da carnitina-octanoil-transferase e carnitina-acetil-transferase. São discutidas as vias metabólicas, sua importância na manutenção da energia muscular durante o exercício prolongado e o papel dos ácidos graxos como fonte energética muscular durante condições normais e patológicas.

  17. Becker muscular dystrophy: an unusual presentation.

    OpenAIRE

    Thakker, P B; Sharma, A

    1993-01-01

    A 15 year old boy who presented with passing painless dark urine was found to have myoglobinuria. His creatine phosphokinase was raised, and a muscle biopsy specimen showed non-specific dystrophic changes. Subsequent DNA analysis led to the diagnosis of Becker muscular dystrophy. Myoglobinuria may be a presenting symptom of Becker muscular dystrophy.

  18. Preimplantation genetic diagnosis of spinal muscular atrophy

    NARCIS (Netherlands)

    Dreesen, JCFM; Bras, M; de Die-Smulders, C; Dumoulin, JCM; Cobben, JM; Evers, JLH; Smeets, HJM; Geraedts, JPM

    After Duchenne muscular dystrophy, spinal muscular atrophy (SMA) is the most common severe neuromuscular disease in childhood. Since 1995, homozygous deletions in exon 7 of the survival motor neuron (SMN) gene have been described in >90-95% of SMA patients. However, the presence of a highly

  19. Roentgenological findings in muscular alterations of extremities

    International Nuclear Information System (INIS)

    Palvoelgyi, R.

    1978-01-01

    A survey of roentgenological findings in muscular alterations of extremities based on the author's experiences and on the literature is presented. Following a description of the normal roentgen anatomy, the alterations in different diseases of interstitial lipomatosis are demonstrated. By roentgenological examinations differt muscular lesions of the extremities can be differentiated and the clinical follow-up verified. (orig.) [de

  20. The end-to-end testbed of the optical metrology system on-board LISA Pathfinder

    Energy Technology Data Exchange (ETDEWEB)

    Steier, F; Cervantes, F Guzman; Marin, A F GarcIa; Heinzel, G; Danzmann, K [Max-Planck-Institut fuer Gravitationsphysik (Albert-Einstein-Institut) and Universitaet Hannover (Germany); Gerardi, D, E-mail: frank.steier@aei.mpg.d [EADS Astrium Satellites GmbH, Friedrichshafen (Germany)

    2009-05-07

    LISA Pathfinder is a technology demonstration mission for the Laser Interferometer Space Antenna (LISA). The main experiment on-board LISA Pathfinder is the so-called LISA Technology Package (LTP) which has the aim to measure the differential acceleration between two free-falling test masses with an accuracy of 3 x 10{sup -14} ms{sup -2} Hz{sup -1/2} between 1 mHz and 30 mHz. This measurement is performed interferometrically by the optical metrology system (OMS) on-board LISA Pathfinder. In this paper, we present the development of an experimental end-to-end testbed of the entire OMS. It includes the interferometer and its sub-units, the interferometer backend which is a phasemeter and the processing of the phasemeter output data. Furthermore, three-axes piezo-actuated mirrors are used instead of the free-falling test masses for the characterization of the dynamic behaviour of the system and some parts of the drag-free and attitude control system (DFACS) which controls the test masses and the satellite. The end-to-end testbed includes all parts of the LTP that can reasonably be tested on earth without free-falling test masses. At its present status it consists mainly of breadboard components. Some of those have already been replaced by engineering models of the LTP experiment. In the next steps, further engineering and flight models will also be inserted in this testbed and tested against well-characterized breadboard components. The presented testbed is an important reference for the unit tests and can also be used for validation of the on-board experiment during the mission.

  1. Theory of the Sagnac's interferometer of low birefringence and twist fiber; Teoria del interferometro de Sagnac de fibra de baja birrefrigencia y torcida

    Energy Technology Data Exchange (ETDEWEB)

    Estudillo-Ayala, J. M.; Kuzin, E. A.; Ibarra-Escamilla, B. [Instituto Nacional de Astrofisica, Optica y Electronica, Puebla (Mexico); Rojas-Laguna, R. [Universidad de Guanajuato, Guanajuato (Mexico)

    2001-06-01

    The fibre Sagnac interferometer of low birefringence and twist in the lineal region is examined numerically, a method is shown to measure the birefringence in the fibers and rotation of the axes inside of the interferometer fibre loop. [Spanish] El interferometro de Sagnac de fibra de baja birrefrigencia y torcida en la region lineal es numericamente examinado, se muestra un metodo para medir la birrefrigencia en las fibras y rotacion de los ejes dentro de la fibra del lazo del interferometro.

  2. Adaptaciones musculares relacionadas a áreas corporales que participan activamente en el vuelo de Anhima cornuta (Aves: Anseriformes, Anhimidae

    Directory of Open Access Journals (Sweden)

    Marcos Antonio Manzanares

    2013-04-01

    Full Text Available La forma y correspondencia entre la anatomía muscular y ósea revela en gran medida el hábito locomotor de cualquier ave. Las especies pertenecientes a la Familia Anhimidae son relevantes dentro de las Aves, debido a las adaptaciones óseas (y por lo tanto, musculares que presentan, como la pérdida de procesos uncinados, el desarrollo de espolones metarcapales, la extrema neumatización y el notable desarrollo de forámenes. Se analizaron anatómicamente y numéricamente (superficie de origen e inserción, longitud en reposo y masa los componentes musculares relacionados a las zonas de la columna vertebral, tronco, miembros y cinturas de tres ejemplares de Anhima cornutade distintos sexos y se compararon con lo estudiado en 4 ejemplares de especies relacionadas (Dendrocygna bicolory Dendrocygna viduata, Anatidae. El estudio reveló que en Anhima existe un gran desarrollo de los músculos intercostales e intervertebrales (torácicos y lumbares, evidenciando una adaptación a la ausencia de procesos uncinados. En Anhimaexisten fascículos proporcionalmente menos pesados y de menor tamaño que en Dendrocygna, indicando morfológicamente la ocurrencia de un vuelo menos desarrollado en el primero. Algunos tendones y fibras musculares metacarpales cuya inserción ocurre en el primer dígito en Dendrocygna, en Anhimase insertan en la base de los espolones proximal y distal, demostrando el poco control del vuelo en Anhima. La musculatura de los miembros posteriores en Anhimaes mucho más desarrollada, tanto en tamaño, como en masa proporcional, evidenciando una gran actividad en esta zona en la propulsión del vuelo y en hábitos terrestres

  3. Study of test-mass charging process in the LISA missions due to diffuse γ-rays

    International Nuclear Information System (INIS)

    Finetti, N; Scrimaglio, R; Grimani, C; Fabi, M

    2009-01-01

    Gravitational inertial sensors will be placed on board the Laser Interferometer Space Antenna (LISA) and aboard its precursor mission LISA Pathfinder (LISA-PF) in order to detect low frequency gravitational waves in space. Free-floating test-masses (Au 7 Pt 3 cubes) will be housed in inertial sensors for detecting possible laser signal variations induced by gravitational waves. Charging of the LISA test-masses due to exposure of the spacecraft to cosmic radiation and energetic solar particles will affect operation of gravitational inertial sensors. In this paper we report on the role of diffuse γ-rays in charging the LISA and LISA-PF test-masses with respect to protons and helium nuclei. The diffuse γ-ray flux in the Galaxy has been interpolated taking into account the outcomes of recent calculations. A comparison with γ-ray observations gathered by different experiments (COMPTEL and EGRET, Milagro, Whipple, HEGRA, TIBET) has been carried out. Simulations of the test-mass charging process have been performed by means of the FLUKA2006.3b package. Monte Carlo simulations of the interaction of cosmic particles with the LISA spacecraft indicate that the diffuse γ-ray contribution to the average steady-state test-mass charging rate and to the single-sided power spectrum of the charge rate noise is marginal with respect to that due to galactic cosmic-rays.

  4. Comportamiento mecánico del concreto reforzado con fibras de bagazo de caña de azúcar

    OpenAIRE

    Espinoza Carvajal, Marlon Jonathan

    2015-01-01

    El tema de investigación que a continuación vamos a describir se centra en el estudio de la incorporación de fibras naturales a una matriz de cemento. Primeramente se evaluó el Estado del Arte, verificando la existencia de estudios que tenga similitud con el tema y sirvan de referentes. Ya en campo empezamos con la recolección de la fibra natural en el Ingenio Monterrey, (MALCA), luego se procede con el aislamiento de la fibra por un tiempo no mayor a tres meses, esto ayuda a que la fibra...

  5. Combinación de fibras de acero de última generación para el refuerzo de hormigón autocompactante

    OpenAIRE

    Alberti, Marcos; Enfedaque, Alejandro; Galvez, Jaime; Cortez, Adriana

    2018-01-01

    [ES] Dado que la mayor desventaja mecánica del hormigón son sus propiedades en tracción, las fibras normalmente se utilizan para mejorar la respuesta frente a solicitaciones de tracción y flexión, siendo las fibras de acero las más comúnmente utilizadas. Este tipo de fibras se ha utilizado con éxito en aplicaciones estructurales en los últimos 50 años y, como consecuencia, se han desarrollado nuevas fibras de acero de última generación de las que existe una bibliografía muy lim...

  6. In-orbit performance of the LISA Pathfinder drag-free and attitude control system

    Science.gov (United States)

    Schleicher, A.; Ziegler, T.; Schubert, R.; Brandt, N.; Bergner, P.; Johann, U.; Fichter, W.; Grzymisch, J.

    2018-04-01

    LISA Pathfinder is a technology demonstrator mission that was funded by the European Space Agency and that was launched on December 3, 2015. LISA Pathfinder has been conducting experiments to demonstrate key technologies for the gravitational wave observatory LISA in its operational orbit at the L1 Lagrange point of the Earth-Sun system until final switch off on July 18, 2017. These key technologies include the inertial sensors, the optical metrology system, a set of µ-propulsion cold gas thrusters and in particular the high performance drag-free and attitude control system (DFACS) that controls the spacecraft in 15 degrees of freedom during its science phase. The main goal of the DFACS is to shield the two test masses inside the inertial sensors from all external disturbances to achieve a residual differential acceleration between the two test masses of less than 3 × 10-14 m/s2/√Hz over the frequency bandwidth of 1-30 mHz. This paper focuses on two important aspects of the DFACS that has been in use on LISA Pathfinder: the DFACS Accelerometer mode and the main DFACS Science mode. The Accelerometer mode is used to capture the test masses after release into free flight from the mechanical grabbing mechanism. The main DFACS Science Mode is used for the actual drag-free science operation. The DFACS control system has very strong interfaces with the LISA Technology Package payload which is a key aspect to master the design, development, and analysis of the DFACS. Linear as well as non-linear control methods are applied. The paper provides pre-flight predictions for the performance of both control modes and compares these predictions to the performance that is currently achieved in-orbit. Some results are also discussed for the mode transitions up to science mode, but the focus of the paper is on the Accelerometer mode performance and on the performance of the Science mode in steady state. Based on the achieved results, some lessons learnt are formulated to extend

  7. Interpretação dos mecanismos de gradação da força muscular através da acelerometria Interpretacion de los mecanismos de graduación de la fuerza muscular a través de la acelerometria Interpretation of the mechanisms related to the muscular strength gradation through accelerometry

    Directory of Open Access Journals (Sweden)

    Thiago Torres da Matta

    2005-10-01

    Full Text Available O objetivo deste estudo foi caracterizar as componentes temporais e espectrais dos abalos musculares em diferentes níveis de contração muscular através da acelerometria. Participaram do estudo 15 indivíduos do sexo masculino e 12 do feminino, todos destros. O experimento constou de um teste de carga máxima (CM que permitiu determinar cinco cargas percentuais administradas durante os testes de força (20%, 40%, 60%, 80% e 100% da CM, em isometria e por oito segundos cada. Um acelerômetro biaxial foi colocado sobre o ventre muscular do bíceps braquial direito. A raiz média quadrática (valor RMS, um parâmetro temporal, e a freqüência média (FME, um parâmetro espectral, foram extraídas dos sinais de acelerometria (sinal de MMG. Estes parâmetros foram analisados nas direções X (perpendicular às fibras e Y (paralela às fibras. Ambos os grupos apresentaram comportamento decrescente da FME (Y com a carga, sendo mais pronunciado para o grupo feminino. A variável FME (X, no grupo feminino, apresentou comportamento semelhante à FME (Y, sendo apenas observada diferença estatística significativa entre 20% da CM e todas as demais cargas (p = 0,0022 para 40% e p El objetivo de este estudio fué el de caracterizar los componentes temporales y espectrales de las alteraciones musculares en diferentes niveles de la contracción muscular a través de la acelerometría. Participaron del estudio 15 individuos del sexo masculino y 12 del sexo femenino todos diestros. El experimento constó de un test de carga máxima (CM que permitió determinar cinco cargas porcentuales administradas durante los tests de fuerza (20%, 40%, 60%, 80% y 100% de la CM, en isometría y por ocho segundos cada una. Un acelerómetro biaxial fué colocado sobre el vientre muscular del bíceps braquial derecho. La raiz média cuadrada (valor RMS, un parámetro temporal, y la frecuencia média (FME, un parámetro espectral, fueron obtenidas de los señales de acelerometr

  8. El Nopal fresco como fuente de fibra y calcio en panqués El Nopal fresco como fuente de fibra y calcio en panqués

    Directory of Open Access Journals (Sweden)

    José Eleazar Barboza- Corona

    2012-02-01

    Full Text Available El objetivo de este trabajo fue utilizar nopal fresco en la formulación de panqués para incrementar su contenido de fibra dietética y calcio. Se desarrollaron cinco formulaciones de panqués utilizando nopal fresco (Opuntia amyclaea Tenore, 4 con sucralosa (una testigo sin nopal y una con azúcar y nopal. Se evaluaron sensorialmente por 60 jueces no entrenados mediante la prueba de preferencia, utilizando una escala hedónica del 1 al 9. Se les determinó el contenido de proteína (Nx6.25, humedad, cenizas, lípidos, hidratos de carbono, fibra dietética total, calcio y fósforo por los métodos de la AOAC, (1990. Los resultados revelaron contenidos de proteínas (Nx6.25 entre 9.54 y 10.08, de humedad entre 35.75 y 40.00, de cenizas, 2.29 g/100 g y 2.44 g/100 g peso húmedo. La evaluación sensorial mostró una buena aceptación, los contenidos de fibra dietética total estuvieron entre 8.27 % y 10.43 % y los de calcio entre 0.27 y 0.375 g/100 g. El valor calórico fue de 216.02 kcal a 225.68 kcal kJ/100 g de panqué, aproximadamente 50 % menos que los que se ofrecen en el mercado. Por su alto contenido de fibra y calcio, ausencia de azúcar y bajo valor calórico estos productos podrían ser una opción saludable para personas diabéticas y obesas.The aim of this work was to utilize fresh cactus as a source of dietary fiber and calciumin pound cake formulations. Five pound cake formulations using fresh cactus (Opuntiaamyclaea Tenore were developed (four with sucralosa, one of them without cactus andone with sugar cane and cactus. Sensory evaluation was performed by 60 untrained judgesand based on a preference assay with a hedonic scale from 1 to 9. Protein (Nx6.25,lipids, ashes, carbohydrates, total dietary fiber, calcium and phosphorus were determinedaccording to the methods of the AOAC, (1990. The results showed protein contentsfrom 9.54 to 10.08, moisture from 35.75 to 40.00, lipids from 2.29 g/100 g y 2.44 g/100g fresh weight. The

  9. Review: Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday (2011 Buchbesprechung: Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday (2011

    Directory of Open Access Journals (Sweden)

    Jigal Beez

    2013-01-01

    Full Text Available Review of the monograph:Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday, Hamburg: Verlag Dr. Kovač, 2011, ISBN 978-3-8300-5806-9, 216 pagesBesprechung der Monographie:Lisa Mackenrodt, Swahili Spirit Possession and Islamic Healing in Contemporary Tanzania: The Jinn Fly on Friday, Hamburg: Verlag Dr. Kovač, 2011, ISBN 978-3-8300-5806-9, 216 Seiten

  10. LISA Pathfinder E2E performance simulation: optical and self-gravity stability analysis

    Science.gov (United States)

    Brandt, N.; Fichter, W.; Kersten, M.; Lucarelli, S.; Montemurro, F.

    2005-05-01

    End-to-end (E2E) modelling and simulation, i.e. verifying the science performance of LISA Pathfinder (spacecraft and payload), is mandatory in order to minimize mission risks. In this paper, focus is on two particular applications of the E2E performance simulator currently being developed at EADS Astrium GmbH: the opto-dynamical stability and the self-gravity disturbance stability analysis. The E2E models applied here comprise the opto-dynamical modelling of the optical metrology systems (OMS) laser interferometry, the thermo-elastic distortion modelling of the OMS optical elements and the self-gravity disturbance model accounting for structural distortions. Preliminary analysis results are presented in detail, identifying shortcomings of the current LISA technology package (LTP) mounting baseline. As a consequence, the design is now being revised.

  11. LISA Pathfinder E2E performance simulation: optical and self-gravity stability analysis

    International Nuclear Information System (INIS)

    Brandt, N; Fichter, W; Kersten, M; Lucarelli, S; Montemurro, F

    2005-01-01

    End-to-end (E2E) modelling and simulation, i.e. verifying the science performance of LISA Pathfinder (spacecraft and payload), is mandatory in order to minimize mission risks. In this paper, focus is on two particular applications of the E2E performance simulator currently being developed at EADS Astrium GmbH: the opto-dynamical stability and the self-gravity disturbance stability analysis. The E2E models applied here comprise the opto-dynamical modelling of the optical metrology systems (OMS) laser interferometry, the thermo-elastic distortion modelling of the OMS optical elements and the self-gravity disturbance model accounting for structural distortions. Preliminary analysis results are presented in detail, identifying shortcomings of the current LISA technology package (LTP) mounting baseline. As a consequence, the design is now being revised

  12. Lifetime testing UV LEDs for use in the LISA charge management system

    Science.gov (United States)

    Hollington, D.; Baird, J. T.; Sumner, T. J.; Wass, P. J.

    2017-10-01

    As a future charge management light source, UV light-emitting diodes (UV LEDs) offer far superior performance in a range of metrics compared to the mercury lamps used in the past. As part of a qualification program a number of short wavelength UV LEDs have been subjected to a series of lifetime tests for potential use on the laser interferometer space antenna (LISA) mission. These tests were performed at realistic output levels for both fast and continuous discharging in either a DC or pulsed mode of operation and included a DC fast discharge test spanning 50 days, a temperature dependent pulsed fast discharge test spanning 21 days and a pulsed continuous discharge test spanning 507 days. Two types of UV LED have demonstrated lifetimes equivalent to over 25 years of realistic mission usage with one type providing a baseline for LISA and the other offering a backup solution.

  13. Lifetime testing UV LEDs for use in the LISA charge management system

    International Nuclear Information System (INIS)

    Hollington, D; Baird, J T; Sumner, T J; Wass, P J

    2017-01-01

    As a future charge management light source, UV light-emitting diodes (UV LEDs) offer far superior performance in a range of metrics compared to the mercury lamps used in the past. As part of a qualification program a number of short wavelength UV LEDs have been subjected to a series of lifetime tests for potential use on the laser interferometer space antenna (LISA) mission. These tests were performed at realistic output levels for both fast and continuous discharging in either a DC or pulsed mode of operation and included a DC fast discharge test spanning 50 days, a temperature dependent pulsed fast discharge test spanning 21 days and a pulsed continuous discharge test spanning 507 days. Two types of UV LED have demonstrated lifetimes equivalent to over 25 years of realistic mission usage with one type providing a baseline for LISA and the other offering a backup solution. (paper)

  14. LISA: A performance assessment code for geological repositories of radioactive waste

    International Nuclear Information System (INIS)

    Bertozzi, G.; Saltelli, A.

    1985-01-01

    LISA, developed at JRC-Ispra, is a statistical code, which calculates the radiation exposures and risks associated with radionuclide releases from geological repositories of nuclear waste. The assessment methodology is described briefly. It requires that a number of probabilistic components be quantified and introduced in the analysis; the results are thus expressed in terms of risk. The subjective judgment of experts may be necessary to quantify the probabilities of occurrence of rare geological events. Because of large uncertainties in input data, statistical treatment of the Monte Carlo type is utilized for the analysis; thus, the output from LISA is obtained in the form of distributions. A few results of an application to a probabilistic scenario for a repository mined in a clay bed are illustrated

  15. Construction of an optical test-bed for eLISA

    International Nuclear Information System (INIS)

    Lieser, Maike; Isleif, K-S; Schuster, S; Tröbs, M; Veith, S; Heinzel, G; Danzmann, K; Fitzsimons, E; Killow, C; Perreur-Lloyd, M; Robertson, D; Ward, H

    2016-01-01

    In the planned eLISA mission a key part of the system is the optical bench that holds the interferometers for reading out the inter-spacecraft distance and the test mass position. We report on ongoing technology development for the eLISA optical system like the back-link between the optical benches and the science interferometer where the local beam is interfered with the received beam from the distant spacecraft. The focus will be on a setup to investigate the tilt-to-pathlength coupling in the science interferometer. To test the science interferometer in the lab a second bench providing a laser beam and a reference interferometer is needed. We present a setup with two ultra-stable low expansion glass benches and bonded optics. To suppress the tilt-to-pathlength coupling to the required level (few μm/rad) imaging optics are placed in front of the interferometer photo diodes. (paper)

  16. The Mock LISA Data Challenges: from Challenge 1B to Challenge 3

    International Nuclear Information System (INIS)

    Babak, Stanislav; Porter, Edward K; Gair, Jonathan; Baker, John G; Arnaud, Keith; Benacquista, Matthew J; Cornish, Neil J; Crowder, Jeff; Vallisneri, Michele; Cutler, Curt; Larson, Shane L; Plagnol, Eric; Vecchio, Alberto; Barack, Leor; Blaut, Arkadiusz; Fairhurst, Stephen; Harry, Ian; Gong Xuefei; Khurana, Deepak; Krolak, Andrzej

    2008-01-01

    The Mock LISA Data Challenges are a programme to demonstrate and encourage the development of LISA data-analysis capabilities, tools and techniques. At the time of this workshop, three rounds of challenges had been completed, and the next was about to start. In this paper we provide a critical analysis of the entries to the latest completed round, Challenge 1B. The entries confirm the consolidation of a range of data-analysis techniques for galactic and massive-black-hole binaries, and they include the first convincing examples of detection and parameter estimation of extreme-mass-ratio inspiral sources. In this paper we also introduce the next round, Challenge 3. Its data sets feature more realistic waveform models (e.g., galactic binaries may now chirp, and massive-black-hole binaries may precess due to spin interactions), as well as new source classes (bursts from cosmic strings, isotropic stochastic backgrounds) and more complicated nonsymmetric instrument noise

  17. arXiv Probing non-Gaussian Stochastic Gravitational Wave Backgrounds with LISA

    CERN Document Server

    Bartolo, Nicola; Figueroa, Daniel G.; Garcia-Bellido, Juan; Peloso, Marco; Pieroni, Mauro; Ricciardone, Angelo; Sakellariadou, Mairi; Sorbo, Lorenzo; Tasinato, Gianmassimo

    The stochastic gravitational wave background (SGWB) contains a wealth of information on astrophysical and cosmological processes. A major challenge of upcoming years will be to extract the information contained in this background and to disentangle the contributions of different sources. In this paper we provide the formalism to extract, from the correlation of three signals in the Laser Interferometer Space Antenna (LISA), information about the tensor three-point function, which characterizes the non-Gaussian properties of the SGWB. Compared to the two-point function, the SGWB three-point function has a richer dependence on the gravitational wave momenta and chiralities, and a larger number of signal channels. It can be used therefore as a powerful discriminator between different models. We provide LISA's response functions to a general SGWB three-point function. As examples, we study in full detail the cases of an equilateral and squeezed SGWB bispectra, and provide the explicit form of the response functio...

  18. LTP - LISA technology package: Development challenges of a spaceborne fundamental physics experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gerndt, R, E-mail: ruediger.gerndt@astrium.eads.ne [Astrium Satellites GmbH, Claude-Dornier-Str., 88090 Immenstaad (Germany)

    2009-03-01

    The LISA Technology Package (LTP) is the main payload onboard the LISA Pathfinder Spacecraft. The LTP Instrument together with the Drag-Free Attitude Control System (DFACS) and the respective LTP and DFACS operational software forms the LTP Experiment. It is completed by the FEEPs of the LPF spacecraft that are controlled by DFACS in order to control the spacecraft's attitude along with the experiment's needs. This article concentrates on aspects of the Industrial development of the LTP Instrument items and on essential performance issues of LTP. Examples of investigations on specific issue will highlight the kind of special problems to be solved for LTP in close cooperation with the Scientific Community.

  19. Detection of Double White Dwarf Binaries with Gaia, LSST and eLISA

    Science.gov (United States)

    Korol, V.; Rossi, E. M.; Groot, P. J.

    2017-03-01

    According to simulations around 108 double degenerate white dwarf binaries are expected to be present in the Milky Way. Due to their intrinsic faintness, the detection of these systems is a challenge, and the total number of detected sources so far amounts only to a few tens. This will change in the next two decades with the advent of Gaia, the LSST and eLISA. We present an estimation of how many compact DWDs with orbital periods less than a few hours we will be able to detect 1) through electromagnetic radiation with Gaia and LSST and 2) through gravitational wave radiation with eLISA. We find that the sample of simultaneous electromagnetic and gravitational waves detections is expected to be substantial, and will provide us a powerful tool for probing the white dwarf astrophysics and the structure of the Milky Way, letting us into the era of multi-messenger astronomy for these sources.

  20. Possible Periodic Orbit Control Maneuvers for an eLISA Mission

    Science.gov (United States)

    Bender, Peter L.; Welter, Gary L.

    2012-01-01

    This paper investigates the possible application of periodic orbit control maneuvers for so-called evolved-LISA (eLISA) missions, i.e., missions for which the constellation arm lengths and mean distance from the Earth are substantially reduced. We find that for missions with arm lengths of 106 km and Earth-trailing distance ranging from approx. 12deg to 20deg over the science lifetime, the occasional use of the spacecraft micro-Newton thrusters for constellation configuration maintenance should be able to essentially eliminate constellation distortion caused by Earth-induced tidal forces at a cost to science time of only a few percent. With interior angle variation kept to approx. +/-0:1deg, the required changes in the angles between the laser beam pointing directions for the two arms from any spacecraft could be kept quite small. This would considerably simplify the apparatus necessary for changing the transmitted beam directions.

  1. Searching for massive black hole binaries in the first Mock LISA Data Challenge

    International Nuclear Information System (INIS)

    Cornish, Neil J; Porter, Edward K

    2007-01-01

    The Mock LISA Data Challenge is a worldwide effort to solve the LISA data analysis problem. We present here our results for the massive black hole binary (BBH) section of round 1. Our results cover challenge 1.2.1, where the coalescence of the binary is seen, and challenge 1.2.2, where the coalescence occurs after the simulated observational period. The data stream is composed of Gaussian instrumental noise plus an unknown BBH waveform. Our search algorithm is based on a variant of the Markov chain Monte Carlo method that uses Metropolis-Hastings sampling and thermostated frequency annealing. We present results from the training data sets where we know the parameter values a priori and the blind data sets where we were informed of the parameter values after the challenge had finished. We demonstrate that our algorithm is able to rapidly locate the sources, accurately recover the source parameters and provide error estimates for the recovered parameters

  2. Supermassive Black Holes as Revealed by LISA: How Gravitational Wave Astronomy Will be a Game Changer

    Science.gov (United States)

    Holley-Bockelmann, Kelly

    2018-04-01

    Astronomers now know that supermassive black holes are in nearly every galaxy.Though these black holes are an observational certainty, nearly every aspect of their evolution -- from their birth, to their fuel source, to their basic dynamics -- is a matter of lively debate. Fortunately, LISA, a space-based gravitational wave observatory set to launch in 2034, will revolutionize this field by providing data that is complementary to electromagnetic observations as well as data in regimes that are electromagnetically dark. This talk will touch on our current understanding of how SMBHs form, evolve, and alter their galaxy host, and will outline the theoretical, computational and observational work needed to make the most of LISA observations.

  3. ESTUDIO DE LA RESISTENCIA MECÁNICA DE MATERIALES COMPUESTOS POLIMÉRICOS REFORZADOS CON FIBRAS DE CARBONO

    Directory of Open Access Journals (Sweden)

    Enrique Rocha-Rangel

    2011-01-01

    Full Text Available Materiales compuestos hechos de una resina epóxica reforzada con diferentes contenidos de fibra de carbono, fueron preparados por dos técnicas de laminación diferentes. Se aplicó 1 Kg/cm2 de presión en los laminados, mientras, que otros laminados se sometieron a un vacío de 1 atm. De los resultados se tiene que las resistencias a la flexión y tensión de los compósitos son mejoradas con el aumento en el contenido de fibra en los mismos. Los compósitos resultantes presentan un mejor comportamiento mecánico bajo esfuerzos de tensión que cuando lo hacen bajo esfuerzos de flexión, debido a que en flexión las fibras se rompen eventualmente, provocando que el material falle a bajos valores de esfuerzo. Cuando los materiales compuestos son sometidos a tensión, las fibras trasmiten los esfuerzos entre ellas y el material falla hasta que se acumula la energía necesaria para romper todas las fibras de una sola vez.

  4. Avaliação da determinação da fibra em detergente neutro e da fibra em detergente ácido pelo sistema ANKOM

    Directory of Open Access Journals (Sweden)

    Berchielli Telma Teresinha

    2001-01-01

    Full Text Available O objetivo do trabalho foi comparar os valores de fibra em detergente neutro (FDN e os de fibra em detergente ácido (FDA obtidos com o equipamento ANKOM e pelo método convencional (Van Soest. No primeiro ensaio foram analisados cinco materiais diferentes (cana-de-açúcar, capim-braquiária, silagem de milho, polpa cítrica e fezes bovina e testados quatro tipos de saquinhos para filtragem de amostra. O delineamento experimental foi em blocos casualizados, em um fatorial 5x4 (cinco materiais diferentes e quatro tipos de saquinhos de filtragem, com três repetições. As médias obtidas foram comparadas àquelas obtidas com método convencional. No segundo ensaio procurou-se avaliar o efeito da quantidade de amostra por saquinho (0,5; 0,8 e 1,0 g sobre os teores de FDN e FDA em três tipos de alimentos, utilizando o ANKOM. Neste ensaio, o delineamento experimental foi em blocos casualizados em esquema fatorial 3x3 (três alimentos x três quantidades, com três repetições. Os tipos de saquinhos de filtragem utilizados não influenciaram os teores de FDN nos diferentes alimentos, com exceção das fezes, cujos saquinhos de náilon resultaram em concentrações de FDN inferiores. Não houve diferença entre os valores de FDN e FDA, obtidos pelo equipamento ANKOM ou pelo convencional, para os alimentos estudados, com exceção da polpa cítrica, cujo valor médio de FDA pelo ANKOM foi inferior àquele obtido pelo método convencional. A quantidade não exerceu efeito sobre a concentração de FDN dos alimentos analisados no equipamento ANKOM.

  5. Structural Organization of Muscular Elements of a Skin-Muscular Sac of Trematodes: Literature Survey

    OpenAIRE

    Kanat Kambarovich Akhmetov; Irina Yurievna Chidunchi

    2015-01-01

    The issue of structural organization of muscular elements of a trematodes’ skin-muscular sac is considered in the study. Special attention is paid to an analysis of materials of preceding researches, study of foreign authors and also to additional literature reflecting peculiarities of structure of a trematodes’ body muscular system. The stated issue is insufficiently studied and calls for further researches. A comparative analysis of places of trematodes’ localization, taking into considerat...

  6. Lisa B Signorello, ScD, ScM | Division of Cancer Prevention

    Science.gov (United States)

    Lisa Signorello is the Director and Chief of the Cancer Prevention Fellowship Program (CPFP) Branch in the National Cancer Institute's Division of Cancer Prevention. Dr. Signorello served as Deputy Director of the CPFP from August 2014 to November 2017 and came to the NCI after having held academic positions at the Harvard School of Public Health, Harvard Medical School, and Vanderbilt University, as well as having had significant private sector research experience. |

  7. Laser frequency stabilization and stray light issues for LISA and other future multi-spacecraft missions Project

    Data.gov (United States)

    National Aeronautics and Space Administration — "The Laser Interferometer Space Antenna (LISA) is a joint NASA/ESA project which will use laser interferometry between drag-free proof masses to measure...

  8. Demonstration of AC and DC charge control for the LISA test masses

    Science.gov (United States)

    Olatunde, Taiwo Janet

    2018-01-01

    Taiwo Olatunde, Stephen Apple, Andrew Chilton, Samantha Parry, Peter Wass, Guido Mueller, John W. Conklin The residual test mass acceleration in LISA must be below 3 fm/s2/√Hz at all frequencies between 0.1 and 3 mHz. Test mass charge coupled with stray electrical potentials and external electromagnetic fields is a well-known source of acceleration noise. LISA Pathfinder uses Hg lamps emitting mostly around 254 nm to discharge the test masses via photoemission, but a future LISA mission launched around 2030 will likely replace the lamps with newer UV LEDs with lower mass, better power efficiency, smaller size and higher bandwidth. This presentation will discuss charge control demonstrated on the torsion pendulum in AC and DC modes at the University of Florida using latest generation UV LEDs producing light at 240 nm with energy above the work function of pure Au. Initial results of Au quantum efficiency measurements (number of emitted electrons per incident photons) which is critical for bi-polar charge control will also be presented.

  9. Renormalized second post-Newtonian spin contributions to the accumulated orbital phase for LISA sources

    International Nuclear Information System (INIS)

    Gergely, Laszlo Arpad; Mikoczi, Balazs

    2009-01-01

    We give here a new third post-Newtonian (3PN) spin-spin contribution (in the PN parameter ε) to the accumulated orbital phase of a compact binary, arising from the spin-orbit precessional motion of the spins. In the equal mass case, this contribution vanishes, but Laser Interferometer Space Antenna (LISA) sources of merging supermassive binary black holes have typically a mass ratio of 1:10. For such nonequal masses, this 3PN correction is periodic in time, with a period approximately ε -1 times larger than the period of gravitational waves. We derive a renormalized and simpler expression of the spin-spin coefficient at 2PN, as an average over the time scale of this period of the combined 2PN and 3PN contribution. We also find that for LISA sources the quadrupole-monopole contribution to the phase dominates over the spin-spin contribution, while the self-spin contribution is negligible even for the dominant spin. Finally, we define a renormalized total spin coefficient σ to be employed in the search for gravitational waves emitted by LISA sources.

  10. Low-Frequency Gravitational-Wave Science with eLISA/ NGO

    Science.gov (United States)

    Amaro-Seoane, Pau; Aoudia, Sofiane; Babak, Stanislav; Binetruy, Pierre; Berti, Emanuele; Bohe, Alejandro; Caprini, Chiara; Colpi, Monica; Cornish, Neil J.; Danzmann, Karsten; hide

    2011-01-01

    We review the expected science performance of the New Gravitational-Wave Observatory (NGO, a.k.a. eLISA), a mission under study by the European Space Agency for launch in the early 2020s. eLISA will survey the low-frequency gravitational-wave sky (from 0.1 mHz to 1 Hz), detecting and characterizing a broad variety of systems and events throughout the Universe, including the coalescences of massive black holes brought together by galaxy mergers; the inspirals of stellar-mass black holes and compact stars into central galactic black holes; several millions of ultracompact binaries, both detached and mass transferring, in the Galaxy; and possibly unforeseen sources such as the relic gravitational-wave radiation from the early Universe. eLISA's high signal-to-noise measurements will provide new insight into the structure and history of the Universe, and they will test general relativity in its strong-field dynamical regime.

  11. Sub-pm{{\\sqrt{Hz}^{-1}}} non-reciprocal noise in the LISA backlink fiber

    Science.gov (United States)

    Fleddermann, Roland; Diekmann, Christian; Steier, Frank; Tröbs, Michael; Heinzel, Gerhard; Danzmann, Karsten

    2018-04-01

    The future space-based gravitational wave detector laser interferometer space antenna (LISA) requires bidirectional exchange of light between its two optical benches on board of each of its three satellites. The current baseline foresees a polarization-maintaining single-mode fiber for this backlink connection. Phase changes which are common in both directions do not enter the science measurement, but differential (‘non-reciprocal’) phase fluctuations directly do and must thus be guaranteed to be small enough. We have built a setup consisting of a Zerodur baseplate with fused silica components attached to it using hydroxide-catalysis bonding and demonstrated the reciprocity of a polarization-maintaining single-mode fiber at the 1 pm \\sqrt{Hz}-1 level as is required for LISA. We used balanced detection to reduce the influence of parasitic optical beams on the reciprocity measurement and a fiber length stabilization to avoid nonlinear effects in our phase measurement system (phase meter). For LISA, a different phase meter is planned to be used that does not show this nonlinearity. We corrected the influence of beam angle changes and temperature changes on the reciprocity measurement in post-processing.

  12. An unusual variant of Becker muscular dystrophy

    NARCIS (Netherlands)

    de Visser, M.; Bakker, E.; Defesche, J. C.; Bolhuis, P. A.; van Ommen, G. J.

    1990-01-01

    We report on 5 brothers with slowly progressive limbgirdle weakness. Calf hypertrophy was absent. The levels of creatine kinase, electromyography, and findings from a muscle biopsy specimen were compatible with muscular dystrophy. The propositus's biopsy specimen also showed numerous rimmed

  13. Physical Therapy and Facioscapulohumeral Muscular Dystrophy (FSHD)

    Science.gov (United States)

    Physical Therapy & FSHD Facioscapulohumeral Muscular Dystrophy A Guide for Patients & Physical Therapists Authors: Wendy M. King, P.T., Assistant ... Shree Pandya, P.T., M.S., Assistant Professor, Neurology & Physical Medicine and Rehabilitation A publication of the FSH ...

  14. How Do People Cope with Muscular Dystrophy?

    Science.gov (United States)

    ... topic are answered in this section. How do people cope with muscular dystrophy (MD)? Although MD presents ... improve health and quality of life. Almost all people with any form of MD experience a worsening ...

  15. Duchenne muscular dystrophy: the management of scoliosis

    Science.gov (United States)

    Gardner, Adrian C.; Roper, Helen P.; Chikermane, Ashish A.; Tatman, Andrew J.

    2016-01-01

    This study summaries the current management of scoliosis in patients with Duchenne Muscular Dystrophy. A literature review of Medline was performed and the collected articles critically appraised. This literature is discussed to give an overview of the current management of scoliosis within Duchenne Muscular Dystrophy. Importantly, improvements in respiratory care, the use of steroids and improving surgical techniques have allowed patients to maintain quality of life and improved life expectancy in this patient group. PMID:27757431

  16. Muscular Oxygen Uptake Kinetics in Aged Adults.

    Science.gov (United States)

    Koschate, J; Drescher, U; Baum, K; Eichberg, S; Schiffer, T; Latsch, J; Brixius, K; Hoffmann, U

    2016-06-01

    Pulmonary oxygen uptake (V˙O2) kinetics and heart rate kinetics are influenced by age and fitness. Muscular V˙O2 kinetics can be estimated from heart rate and pulmonary V˙O2. In this study the applicability of a test using pseudo-random binary sequences in combination with a model to estimate muscular V˙O2 kinetics was tested. Muscular V˙O2 kinetics were expected to be faster than pulmonary V˙O2 kinetics, slowed in aged subjects and correlated with maximum V˙O2 and heart rate kinetics. 27 elderly subjects (73±3 years; 81.1±8.2 kg; 175±4.7 cm) participated. Cardiorespiratory kinetics were assessed using the maximum of cross-correlation functions, higher maxima implying faster kinetics. Muscular V˙O2 kinetics were faster than pulmonary V˙O2 kinetics (0.31±0.1 vs. 0.29±0.1 s; p=0.004). Heart rate kinetics were not correlated with muscular or pulmonary V˙O2 kinetics or maximum V˙O2. Muscular V˙O2 kinetics correlated with maximum V˙O2 (r=0.35; p=0.033). This suggests, that muscular V˙O2 kinetics are faster than estimates from pulmonary V˙O2 and related to maximum V˙O2 in aged subjects. In the future this experimental approach may help to characterize alterations in muscular V˙O2 under various conditions independent of motivation and maximal effort. © Georg Thieme Verlag KG Stuttgart · New York.

  17. Radiographic features of Golden Retriever muscular dystrophy.

    Science.gov (United States)

    Brumitt, Jason W; Essman, Stephanie C; Kornegay, Joe N; Graham, John P; Weber, William J; Berry, Clifford R

    2006-01-01

    Golden Retriever muscular dystrophy is an inherited, degenerative myopathy due to the absence of dystrophin and is used as a model of Duchenne muscular dystrophy of young boys. This report describes the radiographic abnormalities of Golden Retriever muscular dystrophy in 26 dogs. The thoracic abnormalities included diaphragmatic asymmetry (18/26), diaphragmatic undulation (18/26), and gastro-esophageal hiatal hernia (6/26). Pelvic abnormalities included narrowing of the body of the ilia (14/19), ventral deviation and curvature of the tuber ischii (14/19), elongation of the obturator foramen with a decrease in opacity of the surrounding bone (12/19), and lateral flaring of the wings of the ilia (12/19). Abdominal abnormalities consisted of hepatomegaly (14/22) and poor serosal detail (12/22). The unique thoracic abnormalities were a consistent finding in affected Golden Retriever muscular dystrophy dogs. The diagnosis of muscular dystrophy should be included in the differential list if the combination of diaphragm undulation and asymmetry, and gastro-esophageal hiatal hernia are identified. These diaphragmatic abnormalities are related to hypertrophy and hyperplasia of the diaphragm. Additionally, the skeletal changes of pelvic tilt, elongation of the pelvis, widening of the obturator foramina and thinning of the ischiatic tables appear to be specific to Golden Retriever muscular dystrophy in dogs. These pelvic abnormalities are most likely secondary to bone remodeling associated with the progressive skeletal myopathy and subsequent contracture/fibrosis.

  18. Características de adhesión entre fibras de queratina y poliéster insaturado

    Directory of Open Access Journals (Sweden)

    Marco Paniagua

    2008-01-01

    Full Text Available En este trabajo se presentan los métodos y resultados utilizados para determinar las características de adhesión entre fibras de queratina y una matriz de poliéster insaturado. Las fibras fueron preparadas con varios tratamientos superficiales para determinar el efecto de estos en la adhesión a la matriz mediante: i pruebas de desgarre de monofilamento, pull-out, como método directo de medición y ii pruebas de tensión en laminados como método indirecto para estudiar, mediante microscopía electrónica SEM, la adhesión fibra matriz en la zona de fractura.

  19. Spinal and bulbar muscular atrophy.

    Science.gov (United States)

    Lieberman, Andrew P

    2018-01-01

    Spinal and bulbar muscular atrophy (SBMA) is an adult-onset degenerative disorder of the neuromuscular system resulting in slowly progressive weakness and atrophy of the proximal limb and bulbar muscles. The disease is caused by the expansion of a CAG/glutamine tract in the amino-terminus of the androgen receptor. That SBMA exclusively affects males reflects the fact that critical pathogenic events are hormone-dependent. These include translocation of the polyglutamine androgen receptor from the cytoplasm to the nucleus and unfolding of the mutant protein. Studies of the pathology of SBMA subjects have revealed nuclear aggregates of the mutant androgen receptor, loss of lower motor neurons in the brainstem and spinal cord, and both neurogenic and myopathic changes in skeletal muscle. Mechanisms underlying disease pathogenesis include toxicity in both lower motor neurons and skeletal muscle, where effects on transcription, intracellular transport, and mitochondrial function have been documented. Therapies to treat SBMA patients remain largely supportive, although experimental approaches targeting androgen action or promoting degradation of the mutant androgen receptor protein or the encoding RNA are under active study. Copyright © 2018 Elsevier B.V. All rights reserved.

  20. Estudo da Estabilização Termo-Oxidativa de Fitas e Feixes de Fibras de Poliacrilonitrila

    Directory of Open Access Journals (Sweden)

    Costa Andréa M. A. R.

    2002-01-01

    Full Text Available Os estudos relacionados ao processo de fabricação de fibras de carbono indicam que a etapa de estabilização termo-oxidativa das fibras precursoras é limitante, envolvendo reações químicas complexas e mudanças na estrutura física das fibras. Com o objetivo de se conhecer melhor a etapa de estabilização e eliminar gastos em testes experimentais, a modelagem e a simulação surgem para tentar otimizar este processo. Apresenta-se neste trabalho um modelo matemático para a etapa de estabilização de uma fita de fibras de poliacrilonitrila. As equações do modelo descrevem as principais reações químicas de estabilização, a difusão de oxigênio e a transferência de calor na fita. Para a resolução do modelo foi desenvolvido um programa computacional na linguagem Fortran, utilizando os métodos de Colocação Ortogonal e Rungefraction three-quarters Kutta Semi-implícito. Foram obtidos resultados de temperaturas e concentrações na fita de fibras de poliacrilonitrila em função do tempo de estabilização e da posição na espessura da fita. Estes resultados foram analisados e comparados com os simulados em um feixe de fibras de poliacrilonitrila e indicaram que a transferência de calor na fita é melhor do que no feixe e conseqüentemente as reações exotérmicas são mais controladas.

  1. Efeito da fibra do polissacarídeo de soja no peso e na umidade das fezes de ratos em fase de crescimento

    OpenAIRE

    Freitas,Karine C.; Motta,Maria Eugênia F. A.; Amâncio,Olga M. S.; Fagundes Neto,Ulysses; Morais,Mauro B.

    2004-01-01

    OBJETIVO: Comparar, em ratos, o efeito do polissacarídeo de soja em relação a celulose e fórmula de soja sem fibra alimentar sobre o peso e a umidade fecal. MÉTODOS: Foram utilizados 12 ratos Wistar machos, com 21 dias de vida, distribuídos em três grupos, que receberam ração AIN-93G variando-se a fonte de fibra alimentar: grupo polissacarídeo, com 5% de fibra na forma de polissacarídeo de soja; grupo fórmula de soja, com 5% de fórmula de soja sem fibra; e grupo celulose, com 5% de fibra na f...

  2. Variación de la estructura fina de las fibras acrílicas en la hilatura

    OpenAIRE

    Gacén Guillén, Joaquín; Maillo Garrido, Josefina; Manich i Bou, Albert Mª; Ussmane, Mahomed

    2002-01-01

    Dos fibras acrílicas comerciales de diferente finura han sido transformadas en hilados en continua de hilar (3.3. dtex) y en hilatura de rotor (1.3 dtex). Los hilos resultantes han sido vaporizados y teñidos en condiciones standard. Las variaciones de la estructura producidas por las operaciones de hilatura, vaporizado y tintura han sido evaluadas a través del ensayo de solubilidad de las fibras acrílicas en una mezcla dimetilformamida/agua (95/5). Two commercial acrylic fibres of d...

  3. Variación de la estructura fina de las fibras acrílicas en la hilatura

    OpenAIRE

    Gacén Guillén, Joaquín; Maillo Garrido, Josefina; Manich i Bou, Albert Mª; Ussmane, Mahomed

    2002-01-01

    [ESP] Dos fibras acrílicas comerciales de diferente finura han sido transformadas en hilados en continua de hilar (3.3. dtex) y en hilatura de rotor (1.3 dtex). Los hilos resultantes han sido vaporizados y teñidos en condiciones standard. Las variaciones de la estructura producidas por las operaciones de hilatura, vaporizado y tintura han sido evaluadas a través del ensayo de solubilidad de las fibras acrílicas en una mezcla dimetilformamida/agua (95/5).

  4. Fertilidade de substratos para mudas de mangabeira, contendo fibra de coco e adubados com fósforo

    OpenAIRE

    Dias,Thiago Jardelino; Pereira,Walter Esfrain; Sousa,Geocleber Gomes de

    2007-01-01

    Este experimento foi executado no Centro de Ciências Agrárias da UFPB, Areia, Estado da Paraíba, com objetivo de avaliar a fertilidade de substratos compostos por diferentes concentrações de fibra de coco (0 a 40%), esterco bovino (0 a 25%), terra vegetal (25 a 70%), 15% de areia e adubados com superfosfato triplo (0; 5,5 e 11 g L-1). Houve aumento das características químicas desejáveis do substrato com aumento da concentração de terra vegetal, fibra de coco e dose máxima do superfosfato tri...

  5. Hernia hiatal y su relación con la ingestión de fibra dietética

    OpenAIRE

    Rodríguez Miranda, Adelaida; González-Carbajal Pascual, Miguel; Naranjo Hernández, Daysi; Valdés Alonso, Lidunka; Companioni Acosta, Susana

    1995-01-01

    Se estudiaron 226 pacientes con diagnóstico de hernia hiatal por radiología, endoscopia y manometría esofágica y 200 controles normales para determinar la cantidad de fibra dietética ingerida y su relación con la hernia hiatal. Se encontró que los pacientes que presentaron hernia hiatal consumían menos cantidad de fibra dietética que los controles, lo cual fue demostrado estadísticamente.

  6. Papel de la fibra dietética en la prevención de las enfermedades cardiovasculares

    OpenAIRE

    María Zurdo Seijas, Claudia

    2015-01-01

    Las enfermedades cardiovasculares constituyen una de las principales causas de muerte en España. Casi todos los factores de riesgo cardiovascular son modificables, ya que tienen relación con el estilo de vida, y más concretamente, con la alimentación. La relación entre el consumo de fibra y las enfermedades cardiovasculares ha sido muy estudiada, tanto a través de ensayos clínicos como en los grandes estudios de cohortes. El objetivo de este trabajo es describir los tipos de fibra dietética q...

  7. Conocimiento y hábitos en relación a la fibra dietética: resultados preliminaries

    OpenAIRE

    Leal, Marcela; Carranza, C; Herrera, J; Guiné, Raquel

    2015-01-01

    Introducción. El consumo de fibra dietética, y el conocimiento de sus beneficios son fundamentales en el cambio de conducta alimentaria para la prevención de ECNT. Objetivo. Describir los hábitos de consumo de alimentos con fibra dietética y el nivel de conocimiento. Metodología. Estudio cuantitativo, descriptivo, no experimental transversal, parte del proyecto internacional del Instituto Politécnico (Portugal) donde participan 10 países. Muestra no probabilística por voluntarios de 8...

  8. Cardiac involvement in patients with limb-girdle muscular dystrophy type 2 and Becker muscular dystrophy

    DEFF Research Database (Denmark)

    Sveen, Marie-Louise; Thune, Jens Jakob; Køber, Lars

    2008-01-01

    OBJECTIVE: To investigate the extent of cardiac involvement in patients with 1 of the 12 groups of recessively inherited limb-girdle muscular dystrophy type 2 (LGMD2A-L) and Becker muscular dystrophy (BMD). DESIGN: Prospective screening. SETTING: Neuromuscular Clinic and Department of Cardiology...

  9. SÍNTESIS IN SITU DE NANOPARTÍCULAS DE PLATA SOBRE FIBRAS DE FIQUE

    Directory of Open Access Journals (Sweden)

    Sergio Ovalle

    2014-07-01

    Full Text Available Se realizó la síntesis de un material nanocompuesto mediante la deposiciónin situ de nanopartículas (NPs de plata sobre fibras de Fique. La influencia de parámetros experimentales, como concentración del precursor, concentración del agente reductor y tiempos de inmersión de las fibras en la solución del precursor y del agente reductor, se evaluó en términos de recubrimiento, tamaño y dispersión del nanomaterial sobre la superficie. Los nanocompositos fueron caracterizados mediante espectroscopia de reflectancia difusa UV-Vis (RD, microscopía electrónica (FESEM y difracción de rayos X (DRX. El control de los parámetros experimentales mencionados permitió obtener un material que exhibe recubrimiento uniforme y completo de NPs sobre la superficie y tamaños promedio de NPs de 40 nm. 

  10. Método experimental para consolidar fibras de papel. (I parte del estudio

    Directory of Open Access Journals (Sweden)

    Alicia De Lera Santín

    2009-08-01

    Full Text Available En este artículo describimos un nuevo método enzimático para consolidar la celulosa del papel. Este método consiste en la síntesis de la celulosa con una enzima hidrolítica: la celulasa. Ésta actúa como una sintetasa, consolidando el papel cuando es mezclada en una solución orgánica de solvente/tampón (4:1 en presencia de un sustrato (β-cellobiosyl fluoride. Para mejorar el tratamiento añadimos un gel de agar-agar con todos los reactivos necesarios. Para observar el estado de las fibras antes y después del tratamiento, realizamos test mecánicos y fotografías de microscopía electrónica de barrido. Se observó que el proceso de consolidación casi consigue recuperar el estado físico inicial de las fibras así como su resistencia al desgarre y alargamiento.

  11. Muscular cystic hydatidosis: case report

    Directory of Open Access Journals (Sweden)

    Naspetti Riccardo

    2007-03-01

    Full Text Available Abstract Background Hydatidosis is a zoonosis caused by Echinococcus granulosus, and ingesting eggs released through the faeces from infected dogs infects humans. The location of the hydatid cysts is mostly hepatic and/or pulmonary, whereas musculoskeletal hydatidosis is very rare. Case presentation We report an unusual case of primary muscular hydatidosis in proximity of the big adductor in a young Sicilian man. The patient, 34 years old, was admitted to the Department of Infectious and Tropical Diseases for ultrasonographic detection, with successive confirmation by magnetic resonance imaging, of an ovular mass (13 × 8 cm in the big adductor of the left thigh, cyst-like, and containing several small cystic formations. Serological tests for hydatidosis gave negative results. A second drawing of blood was done 10 days after the first one and showed an increase in the antibody titer for hydatidosis. The patient was submitted to surgical excision of the lesion with perioperatory prophylaxis with albendazole. The histopathological examination of the bioptic material was not diriment in the diagnosis, therefore further tests were performed: additional serological tests for hydatidosis for the evaluation of IgE and IgG serotype (Western Blot and REAST, and molecular analysis of the excised material. These more specific serological tests gave positive results for hydatidosis, and the sequencing of the polymerase chain reaction products from the cyst evidenced E. granulosus DNA, genotype G1. Any post-surgery complications was observed during 6 following months. Conclusion Cystic hydatidosis should always be considered in the differential diagnosis of any cystic mass, regardless of its location, also in epidemiological contests less suggestive of the disease. The diagnosis should be achieved by taking into consideration the clinical aspects, the epidemiology of the disease, the imaging and immunological tests but, as demonstrated in this case, without

  12. FIBRAS ANIMALES ARQUEOLÓGICAS. ESTUDIO DE LA ESTRUCTURA FÍSICA CELULAR DE LAS FIBRAS/Archaeological animal fibres. Study of their physical cellular structure

    Directory of Open Access Journals (Sweden)

    María del Carmen Reigadas

    2012-11-01

    Full Text Available El análisis microscópico de la morfología de fibras animales se ha empleado conjuntamente con otras líneas de evidencia, brindando información taxonómica útil para reconstruir posibles escenarios que den cuenta de las estrategias implementadas por las sociedades cazadoras- recolectoras y/ o productoras, en vistas a la explotación y aprovechamiento de los recursos animales. En esta oportunidad y en el marco de la vía mencionada, se presenta como complemento de los resultados obtenidos a partir de las variables cualitativas y cuantitativas tales como grosor, médula, tipo de fibra y color, el avance realizado en el estudio de la corteza, estructura no contemplada hasta el presente. Se evalúa a partir de la información generada su relevancia en la búsqueda de indicadores interespecíficos. El análisis fue realizado en muestras correspondientes al nivel 4 del sitio Cueva Salamanca 1 (7500 + 60 AP [Beta 178223] (Pintar 2004 y nivel 4 de Quebrada Seca 3 (Cal. 3684- 4226 1s (Aschero et al. 1993-94, ambos localizados en la puna meridional (Antofagasta de la Sierra, Argentina de las cuales ya se disponen designaciones taxonómicas obtenidas por análisis morfológico. Abstract Microscopic analysis of the morphology of animal fibers has been used in conjunction with other lines of evidence, providing useful taxonomic information to reconstruct scenarios that account for the strategies implemented by hunter-gatherers and producers, in view of the use of animal resources. Here, the advance made in the study of cortical cells is offered as a complement to results obtained from qualitative and quantitative variables such as thickness, medulla, fiber type and color. The information gained is used to evaluate the relevance in the search of interspecific indicators. The analysis was performed on samples corresponding to level 4 from Cueva Salamanca 1 (7500 ± 60 BP [Beta 178223] (Pintar 2004 and level 4 from Quebrada Seca 3 (Cal. 3684 to 4226 1s

  13. Automatic system for quantification and visualization of lung aeration on chest computed tomography images: the Lung Image System Analysis - LISA

    Energy Technology Data Exchange (ETDEWEB)

    Felix, John Hebert da Silva; Cortez, Paulo Cesar, E-mail: jhsfelix@gmail.co [Universidade Federal do Ceara (UFC), Fortaleza, CE (Brazil). Dept. de Engenharia de Teleinformatica; Holanda, Marcelo Alcantara [Universidade Federal do Ceara (UFC), Fortaleza, CE (Brazil). Hospital Universitario Walter Cantidio. Dept. de Medicina Clinica

    2010-12-15

    High Resolution Computed Tomography (HRCT) is the exam of choice for the diagnostic evaluation of lung parenchyma diseases. There is an increasing interest for computational systems able to automatically analyze the radiological densities of the lungs in CT images. The main objective of this study is to present a system for the automatic quantification and visualization of the lung aeration in HRCT images of different degrees of aeration, called Lung Image System Analysis (LISA). The secondary objective is to compare LISA to the Osiris system and also to specific algorithm lung segmentation (ALS), on the accuracy of the lungs segmentation. The LISA system automatically extracts the following image attributes: lungs perimeter, cross sectional area, volume, the radiological densities histograms, the mean lung density (MLD) in Hounsfield units (HU), the relative area of the lungs with voxels with density values lower than -950 HU (RA950) and the 15th percentile of the least density voxels (PERC15). Furthermore, LISA has a colored mask algorithm that applies pseudo-colors to the lung parenchyma according to the pre-defined radiological density chosen by the system user. The lungs segmentations of 102 images of 8 healthy volunteers and 141 images of 11 patients with Chronic Obstructive Pulmonary Disease (COPD) were compared on the accuracy and concordance among the three methods. The LISA was more effective on lungs segmentation than the other two methods. LISA's color mask tool improves the spatial visualization of the degrees of lung aeration and the various attributes of the image that can be extracted may help physicians and researchers to better assess lung aeration both quantitatively and qualitatively. LISA may have important clinical and research applications on the assessment of global and regional lung aeration and therefore deserves further developments and validation studies. (author)

  14. Automatic system for quantification and visualization of lung aeration on chest computed tomography images: the Lung Image System Analysis - LISA

    International Nuclear Information System (INIS)

    Felix, John Hebert da Silva; Cortez, Paulo Cesar; Holanda, Marcelo Alcantara

    2010-01-01

    High Resolution Computed Tomography (HRCT) is the exam of choice for the diagnostic evaluation of lung parenchyma diseases. There is an increasing interest for computational systems able to automatically analyze the radiological densities of the lungs in CT images. The main objective of this study is to present a system for the automatic quantification and visualization of the lung aeration in HRCT images of different degrees of aeration, called Lung Image System Analysis (LISA). The secondary objective is to compare LISA to the Osiris system and also to specific algorithm lung segmentation (ALS), on the accuracy of the lungs segmentation. The LISA system automatically extracts the following image attributes: lungs perimeter, cross sectional area, volume, the radiological densities histograms, the mean lung density (MLD) in Hounsfield units (HU), the relative area of the lungs with voxels with density values lower than -950 HU (RA950) and the 15th percentile of the least density voxels (PERC15). Furthermore, LISA has a colored mask algorithm that applies pseudo-colors to the lung parenchyma according to the pre-defined radiological density chosen by the system user. The lungs segmentations of 102 images of 8 healthy volunteers and 141 images of 11 patients with Chronic Obstructive Pulmonary Disease (COPD) were compared on the accuracy and concordance among the three methods. The LISA was more effective on lungs segmentation than the other two methods. LISA's color mask tool improves the spatial visualization of the degrees of lung aeration and the various attributes of the image that can be extracted may help physicians and researchers to better assess lung aeration both quantitatively and qualitatively. LISA may have important clinical and research applications on the assessment of global and regional lung aeration and therefore deserves further developments and validation studies. (author)

  15. Análise histológica e histoquímica das fibras dos músculos reto do abdome e intercostal paraesternal de ratos submetidos ao exercício da natação Histologic and histochemical analysis of fibers of rectus of abdomen and paraesternal intercostal muscles of Wistar rats after swimming exercise

    Directory of Open Access Journals (Sweden)

    Paulo César Bálade Saad

    2002-08-01

    Full Text Available O objetivo deste trabalho foi o de analisar, através de técnicas histológicas e reações histoquímicas, se o exercício induziria alterações nas fibras musculares dos músculos reto do abdome (expiratório e intercostal paraesternal (inspiratório. Para tanto, ratos da linhagem Wistar, divididos em grupos controle e treinado, foram submetidos à adaptação e, em seguida, ao treinamento da natação por 15, 30, 45 e 60 dias, 1h/dia, cinco dias/semana. Ao término do experimento os animais foram sacrificados, os músculos retirados e congelados em N-hexana resfriada a -70ºC em N2. Os cortes histológicos (7µm foram feitos em micrótomo criostato a -20ºC, procedendo-se então à confecção das lâminas para a análise da morfologia geral (HE, análise da capacidade oxidativa (NADH-TR e habilidade contrátil (ATPase miofibrilar, para verificação dos percentuais dos tipos de fibras musculares. Os músculos estudados revelaram fibras com contornos poligonais e com diferentes diâmetros, sendo de três tipos básicos; SO (slow oxydative, FOG (fast oxydative glycolitic e FG (fast glycolitic, com distribuição em mosaico. A análise dos resultados demonstrou que o músculo reto do abdome apresentou aumento significativo nos percentuais de fibras SO e diminuição das fibras FOG nos animais que nadaram durante 60 dias, e aumento das fibras FG para os ratos que nadaram durante 15 dias. O músculo intercostal paraesternal apresentou aumento significativo nos percentuais das fibras SO nos animais que nadaram durante 60 dias, aumento de fibras FOG para os que nadaram durante 45 e 60 dias e diminuição das fibras FG para os que nadaram durante 30, 45 e 60 dias. Dos fatos, pode-se concluir que, no exercício da natação os músculos inspiratórios realizaram maior trabalho devido à pressão hidrostática, aumento da freqüência respiratória e aumento da resistência elástica pulmonar, e que, para isso, houve a necessidade de maior adapta

  16. Non-linear quantization error reduction for the temperature measurement subsystem on-board LISA Pathfinder

    Science.gov (United States)

    Sanjuan, J.; Nofrarias, M.

    2018-04-01

    Laser Interferometer Space Antenna (LISA) Pathfinder is a mission to test the technology enabling gravitational wave detection in space and to demonstrate that sub-femto-g free fall levels are possible. To do so, the distance between two free falling test masses is measured to unprecedented sensitivity by means of laser interferometry. Temperature fluctuations are one of the noise sources limiting the free fall accuracy and the interferometer performance and need to be known at the ˜10 μK Hz-1/2 level in the sub-millihertz frequency range in order to validate the noise models for the future space-based gravitational wave detector LISA. The temperature measurement subsystem on LISA Pathfinder is in charge of monitoring the thermal environment at key locations with noise levels of 7.5 μK Hz-1/2 at the sub-millihertz. However, its performance worsens by one to two orders of magnitude when slowly changing temperatures are measured due to errors introduced by analog-to-digital converter non-linearities. In this paper, we present a method to reduce this effect by data post-processing. The method is applied to experimental data available from on-ground validation tests to demonstrate its performance and the potential benefit for in-flight data. The analog-to-digital converter effects are reduced by a factor between three and six in the frequencies where the errors play an important role. An average 2.7 fold noise reduction is demonstrated in the 0.3 mHz-2 mHz band.

  17. Modulator noise suppression in the LISA time-delay interferometric combinations

    International Nuclear Information System (INIS)

    Tinto, Massimo; Armstrong, J W; Estabrook, Frank B

    2008-01-01

    Laser Interferometer Space Antenna (LISA) is a mission to detect and study low-frequency cosmic gravitational radiation through its influence on the phases of six modulated laser beams exchanged between three remote spacecraft. We previously showed how the measurements of some 18 time series of relative frequency or phase shifts could be combined (1) to cancel the phase noise of the lasers, (2) to cancel the Doppler fluctuations due to non-inertial motions of the six optical benches and (3) to remove the phase noise of the onboard reference oscillators required to track the photodetector fringes, all the while preserving signals from passing gravitational waves. Here we analyze the effect of the additional noise due to the optical modulators used for removing the phase fluctuations of the onboard reference oscillators. We use the recently measured noise spectrum of an individual modulator (Klipstein et al 2006 Proc. 6th Int. LISA Symp. (Greenbelt, MA) (AIP Conf. Proc. vol 873) ed S M Merkowitz and J C Livas pp 19-23) to quantify the contribution of modulator noise to the first and second-generation time-delay interferometric (TDI) combinations as a function of the modulation frequency. We show that modulator noise can be made smaller than the expected proof-mass acceleration and optical-path noises if the modulation frequencies are larger than ∼682 MHz in the case of the unequal-arm Michelson TDI combination X 1 , ∼ 1.08 GHz for the Sagnac TDI combination α 1 , and ∼706 MHz for the symmetrical Sagnac TDI combination ζ 1 . These modulation frequencies are substantially smaller than previously estimated and may lead to less stringent requirements on the LISA's oscillator noise calibration subsystem. The measurements in Klipstein et al were performed in a laboratory experiment for a range of modulation frequencies, but we emphasize that, for the reference oscillator noise calibration algorithm to work, the modulation frequencies must be equal to the

  18. CONSUMO DE FIBRA DIETÉTICA EN LACTANTES MENORES DE 2 AÑOS Y ESTREÑIMIENTO FUNCIONAL

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Velasco Benítez

    2014-09-01

    Full Text Available Introducción: La inclusión de la fibra dietética (FD, tiene múltiples beneficios sobre la salud del ser humano; sin embargo, en pediatría, existen grandes brechas concernientes a la relación de fibra y estreñimiento. Objetivo: Describir el hábito intestinal en lactantes . Se tuvo en cuenta la alimentación con leche materna, el tiempo de inicio de alimentación complementaria y el antecedente de madre o cuidador con EF. Los resultados son expresados como X±DS. El análisis estadístico incluyó X2 y prueba de Spearman  o Fischer. Resultados: Se estudiaron 125 lactantes de 13±7 meses, 86 masculinos. No hubo diferencias significativas en edad, sexo, consumo de gramos de fibra/d, ni con la alimentación con leche materna, el tiempo de inicio de la alimentación complementaria y el antecedente de madre o cuidador con EF. Conclusión: No encontramos ninguna asociación entre hábito intestinal y gramos de fibra consumidos, ni alimentación con leche materna, inicio de la alimentación complementaria precoz y antecedente de EF en la madre o cuidador.

  19. Massive Black Hole Mergers: Can We "See" what LISA will "Hear"?

    Science.gov (United States)

    Centrella, Joan

    2010-01-01

    The final merger of massive black holes produces strong gravitational radiation that can be detected by the space-borne LISA. If the black hole merger takes place in the presence of gas and magnetic fields, various types of electromagnetic signals may also be produced. Modeling such electromagnetic counterparts of the final merger requires evolving the behavior of both gas and fields in the strong-field regions around the black holes. We will review current efforts to simulate these systems, and discuss possibilities for observing the electromagnetic signals they produce.

  20. LISA - a powerful program package for LIstmode and Spectral data Analysis

    International Nuclear Information System (INIS)

    Oberstedt, A.; Hambsch, F.J.

    1994-01-01

    LISA is a graphical program package which enables both off-line listmode and spectral data evaluation as well as on-line monitoring while multi-parameter experiments are running. It can be executed on every computer with a UNIX operating system and an X-WINDOW environment, running PV-WAVE from Visual Numerics Incorporation. This package is basically written in the language PV-WAVE CL, but integration of procedures written in the C-language and execution of UNIX shell commands lead to an additional increase of performance. (orig.)

  1. On-orbit alignment and diagnostics for the LISA Technology Package

    International Nuclear Information System (INIS)

    MarIn, A F GarcIa; Wand, V; Steier, F; Cervantes, F Guzman; Bogenstahl, J; Jennrich, O; Heinzel, G; Danzmann, K

    2006-01-01

    This paper presents a procedure to perform fully autonomous on-orbit alignment of the interferometer on board the LISA Technology Package (LTP). LTP comprises two free-floating test masses as inertial sensors that additionally serve as end mirrors of a set of interferometers. From the output signals of the interferometers, a subset has been selected to obtain alignment information of the test masses. Based on these signals, an alignment procedure was developed and successfully tested on the engineering model of the optical bench. Furthermore, operation procedures for the characterization of critical on-orbit properties of the optical metrology system (e.g. fibre noise) have been established

  2. After-dinner speech: the path of LISA to become ‘L3’

    Science.gov (United States)

    Huber, M. C. E.

    2017-05-01

    We describe the state of fundamental-physics experiments in space in the mid 1980s on both sides of the Atlantic, and then follow the development of this field within ESA’s Scientific Programme. The special case of LISA — a fundamental physics experiment in space also supported by astronomers, and now, following the ground-based detection of gravitational waves, the means to extend the observable spectrum of such waves towards lower frequencies and long-lasting signals — is then followed in its rise to become the ‘Large Project L3’ of ESA.

  3. Observing extreme-mass-ratio inspirals with eLISA/NGO

    OpenAIRE

    Gair, Jonathan R; Porter, Edward K

    2012-01-01

    The extreme-mass-ratio inspirals (EMRIs) of stellar mass compact objects into massive black holes in the centres of galaxies are an important source of low-frequency gravitational waves for space-based detectors. We discuss the prospects for detecting these sources with the evolved Laser Interferometer Space Antenna (eLISA), recently proposed as an ESA mission candidate under the name NGO. We show that NGO could observe a few tens of EMRIs over its two year mission lifetime at redshifts z < 0...

  4. LISA. A code for safety assessment in nuclear waste disposals program description and user guide

    International Nuclear Information System (INIS)

    Saltelli, A.; Bertozzi, G.; Stanners, D.A.

    1984-01-01

    The code LISA (Long term Isolation Safety Assessment), developed at the Joint Research Centre, Ispra is a useful tool in the analysis of the hazard due to the disposal of nuclear waste in geological formations. The risk linked to preestablished release scenarios is assessed by the code in terms of dose rate to a maximum exposed individual. The various submodels in the code simulate the system of barriers -both natural and man made- which are interposed between the contaminants and man. After a description of the code features a guide for the user is supplied and then a test case is presented

  5. Effects of different eLISA-like configurations on massive black hole parameter estimation

    Science.gov (United States)

    Porter, Edward K.

    2015-09-01

    As the theme for the future L3 Cosmic Vision mission, ESA has recently chosen the "Gravitational Wave Universe." Within this program, a mission concept called eLISA has been proposed. This observatory has a current initial configuration consisting of four laser links between the three satellites, which are separated by a distance of one million kilometers, constructing a single-channel Michelson interferometer. However, the final configuration for the observatory will not be fixed until the end of this decade. With this in mind, we investigate the effect of different eLISA-like configurations on massive black hole detections. This work compares the results of a Bayesian inference study of 120 massive black hole binaries out to a redshift of z ˜13 for a 106 km arm length eLISA with four and six links, as well as a 2 ×106 km arm length observatory with four links. We demonstrate that the original eLISA configuration should allow us to recover the luminosity distance of the source with an error of less than 10% out to a redshift of z ˜4 , and a sky error box of Δ Ω ≤102 deg2 out to z ˜0.1 . In contrast, both alternative configurations suggest that we should be able to conduct the same parameter recovery with errors of less than 10% in luminosity distance out to z ˜12 and Δ Ω ≤102 deg2 out to z ˜0.4 . Using the information from these studies, we also infer that if we were able to construct a 2 Gm, six-link detector, the above values would shift to z ˜20 for luminosity distance and z ˜0.9 for sky error. While the final configuration will also be dependent on both technological and financial considerations, our study suggests that increasing the size of a two-arm detector is a viable alternative to the inclusion of a third arm in a smaller detector. More importantly, this work further suggests no clear scientific loss between either choice.

  6. Aspectos ultra-estruturais da fibra muscular cardíaca de ratas albinas durante o ciclo gravídico-puerperal

    Directory of Open Access Journals (Sweden)

    Liberatori Filho A.W.

    1999-01-01

    Full Text Available OBJETIVO. No presente estudo avaliamos, por intermédio da microscopia eletrônica de transmissão, a morfologia dos cardiomiócitos do ventrículo esquerdo de ratas albinas no decorrer do ciclo gravídico-puerperal. MÉTODOS. Obtida a prenhez, 77 ratas foram divididas ao acaso em dois grupos denominados, respectivamente, de: gestação (G e puerpério (P. Os animais pertencentes ao grupo gestação foram ainda subdivididos em quatro subgrupos, de acordo com a idade gestacional; 1o (G-A, 7o (G-B, 14o (G-C e 21o (G-D dias de prenhez. O grupo definido como puerpério foi também subdividido em três subgrupos; 7o (P-A, 14o (P-B e 21o (P-C dias de puerpério. Findo o período estabelecido para cada subgrupo, os animais foram sacrificados, sendo coletados fragmentos do terço médio do ventrículo esquerdo, os quais após processamento apropriado, permitiram observação adequada à microscopia eletrônica de transmissão. RESULTADOS. Os resultados obtidos demonstraram hipertrofia gradativos dos cardiomiócitos no decorrer da prenhez (aumento das miofibrilas, que ao final da gestação apresentaram-se entremeadas de numerosas mitocôndrias. As paredes dos capilares sangüíneos, progressivamente, tornaram-se mais delgadas, com aumento das vesículas de pinocitose no interior das células endoteliais. Revelou ainda, acentuadas dobras do sarcolema em nível dos túbulos T (túneis capilares. No grupo puerpério, notamos gradativa regressão nessas alterações, com retorno às características pré-gestacionais. Os achados demonstram a ocorrência de hipertrofia no decorrer da gestação. CONCLUSÃO. Durante a prenhez há hipertrofia em cardiomiócito do ventrículo esquerdo com regressão durante o puerpério.

  7. [Human myopathy and animal muscular dystrophy].

    Science.gov (United States)

    Schapira, G; Dreyfus, J C; Schapira, F

    1977-08-01

    Two hereditary muscular dystrophies similar to human progressive muscular dystrophy (P.M.D. Duchenne type) have been isolated in animals, one in mouse, the other in chicken. The decrease in the activity of glycogenolytic enzymes is similar to that observed in denervated muscle. Isozymic fetal types for several muscular enzymes have been observed as well in chicken as in man, but this fetal type may also be found in neurogenic atrophy. The release in circulation of muscle enzymes seems more specific. But the origin of the genetic lesion is still unknown. We describe here the three different theories about this problem: i.e. neurogenic, vascular, or myogenic. This last theory implies a trouble of membrane permeability.

  8. Mitochondrial disorders in progressive muscular dystrophies

    Directory of Open Access Journals (Sweden)

    D. A. Kharlamov

    2014-01-01

    Full Text Available The literature review gives data on the role of mitochondrial disorders in the pathogenesis of different progressive muscular dystrophies. It describes changes in Duchenne, limb-girdle, facial scapulohumeral (Landuzi—Degerina muscular dystrophies. The review is based on both clinical and experimental animal studies. Along with the implication of mitochondria in the pathogenesis of the diseases, it describes muscular dystrophy treatment options compensating for energy disorders and overcoming oxidative stress and mitochondrial dysfunction. Mitochondrial studies in different muscle diseases hand physicians treatment modalities that fail to lead to recovery, but compensate for disorders caused by mutations in the genetic apparatus. 

  9. Muscular pathology: echographic and NMR imaging aspects

    International Nuclear Information System (INIS)

    Pascal-Suisse, P.; Beaurain, P.; Mougniot, C.

    1995-01-01

    A comparison of echographic techniques and NMR imaging has been done for the diagnosis of muscular trauma and tumor pathologies. In traumatic pathology, the echographic analysis allows to determine the complete assessment of recent muscular injuries. NMR imaging can be used in granuloma or fibrous callosity appreciation and for the analysis of deep injury (muscles and muscles-tendon junctions) and of muscular aponeurosis. Echography must be used together with color coding Doppler technique in the diagnosis of tumor pathology and for the study of slow fluxes. The recently available energy Doppler technique seems to be powerful in the study of vascularization of small expansive formations, but their extension to adjacent bone or tissue can only be appreciated using NMR imaging. (J.S.)

  10. Comportamiento al corte de hormigones reforzado con fibras de acero Shear behavior of steel fiber reinforced concretes

    Directory of Open Access Journals (Sweden)

    Sergio Carmona Malatesta

    2009-01-01

    Full Text Available En este artículo se presentan los resultados de un estudio experimental a cerca de la influencia de la incorporación de fibras de acero en el comportamiento del hormigón frente a esfuerzos de corte, medidos utilizando el ensayo JSCE - SF6, modificado. Usando los resultados de los ensayos realizados se evalúa La capacidad de disipación de energía del hormigón durante la rotura o tenacidad del hormigón reforzado con fibras en función del contenido y tipo de Fibra utilizada. Con los resultados obtenidos, se puede concluir que la incorporación de fibras como refuerzo al esfuerzo de corte aumenta la ductilidad del hormigón, permitiendo mayores deformaciones que un hormigón convencional. Se observa que la capacidad de absorber energía de los hormigones, cuantificada a través de la tenacidad absoluta, se incrementa más de tres veces cuando se incorporar fibras y no se tienen roturas frágiles. Por lo tanto, la incorporación de fibras como refuerzo es una buena solución para mejorar la respuesta del hormigón ante solicitaciones de corte. Por otra parte, se demuestra que el ensayo de corte propuesto por la recomendación japonesa JSCE-SF6, levemente modificada, entrega resultados coherentes y reproducibles, permitiendo cuantificar diferentes propiedades del hormigón reforzado con fibras sometido a solicitaciones de corte.This paper presents the results of an experimental research on influence of steel fibers on shear behavior of concrete, using modified JSCE - SF6 test. The tests results are used to evaluate the energy dissipation capacity of concrete during failure or fiber reinforced concrete toughness, in terms of amount and type of fibers. With the results, it can be concluded that the addition of fibers as shear reinforcement influence significantly the ductility of concrete. The results show that the absorption energy capacity of concrete, measured by mean of absolute toughness, increase 3 times when concrete is reinforced with

  11. Constraining early and interacting dark energy with gravitational wave standard sirens: the potential of the eLISA mission

    International Nuclear Information System (INIS)

    Caprini, Chiara; Tamanini, Nicola

    2016-01-01

    We perform a forecast analysis of the capability of the eLISA space-based interferometer to constrain models of early and interacting dark energy using gravitational wave standard sirens. We employ simulated catalogues of standard sirens given by merging massive black hole binaries visible by eLISA, with an electromagnetic counterpart detectable by future telescopes. We consider three-arms mission designs with arm length of 1, 2 and 5 million km, 5 years of mission duration and the best-level low frequency noise as recently tested by the LISA Pathfinder. Standard sirens with eLISA give access to an intermediate range of redshift 1 ∼< z ∼< 8, and can therefore provide competitive constraints on models where the onset of the deviation from ΛCDM (i.e. the epoch when early dark energy starts to be non-negligible, or when the interaction with dark matter begins) occurs relatively late, at z ∼< 6. If instead early or interacting dark energy is relevant already in the pre-recombination era, current cosmological probes (especially the cosmic microwave background) are more efficient than eLISA in constraining these models, except possibly in the interacting dark energy model if the energy exchange is proportional to the energy density of dark energy.

  12. Efeito do exercício físico e estatinas na função muscular em animais com dislipidemia

    Directory of Open Access Journals (Sweden)

    Marilita Falângola Accioly

    2012-06-01

    Full Text Available As estatinas são utilizadas no tratamento das dislipidemias, com grande tolerância; no entanto, vários efeitos colaterais podem surgir, destacando-se miopatia. A prática regular do exercício físico (EF produz modificações favoráveis no perfil lipídico; entretanto, pode gerar lesões musculares. OBJETIVO: Avaliar o efeito da associação entre exercício físico e estatinas na função muscular, pela análise histológica, em modelo experimental animal com dislipidemia. MÉTODOS: Foram utilizados 80 ratos machos Wistar, distribuídos em oito grupos, incluindo animais submetidos à dieta hipercolesterolêmica (DH, sinvastatina com (G1 e sem (G2 EF; DH e fluvastatina, com (G3 e sem EF (G4; alimentados com ração comercial (RC na presença (G5 e ausência de (G6 EF; DH submetidos (G7 ou não (G8 a EF. A DH foi administrada por 90 dias, as estatinas e prática de EF em esteira rolante por oito semanas. Os animais foram sacrificados, e o músculo sóleo retirado para análise histológica. Aplicaram-se os testes t de Student pareado e análise multivariada, com nível significante para p < 0,05. RESULTADOS: As principais alterações histológicas encontradas foram fibras de diferentes diâmetros, atróficas, em degeneração, splitting, edema, infiltrado inflamatório. Essas alterações foram observadas em 90% dos animais do grupo G1, 80% do G2, 70% do G3, 30% do G4, 40% do G5 e 30% do G7. Nos grupos G6 e G8 identificaram-se fibras musculares com morfologia preservada. CONCLUSÕES: Na avaliação histológica muscular, a associação entre fluvastatina, sinvastatina e exercício físico acarreta alterações morfológicas com predomínio no uso da sinvastatina, variando de grau leve a grave, no músculo sóleo de ratos, induzidos pelos inibidores da HMG-CoA redutase.

  13. Características musculares y producción de fuerza máxima/explosiva durante acciones isométricas/dinámicas de los músculos extensores de los miembros inferiores en jóvenes no entrenados

    OpenAIRE

    Izquierdo, M.; Aguado, X.; González, J. L.; López, J. L.; Ribas, T.; Linares, F.; Vila, L.; Voces, J. A.; Álvarez, A. I.; Prieto, J. G.

    1997-01-01

    Participaron en el estudio, de forma voluntaria cinco sujetos de sexo masculino, estudiantes de educación Física (22-26 años). El objetivo fue observar las relaciones entre el test de salto horizontal con los tests de salto vertical con contramovimiento y con flexión previa, tests de fuerza isométrica máxima y la distribución de los tipos de fibras musculares. Los resultados en la distancia y altura de vuelo conseguidas en los tests de salto horizontal, salto desde flexión previa sin cont...

  14. Genetics Home Reference: spinal muscular atrophy with progressive myoclonic epilepsy

    Science.gov (United States)

    ... myoclonic epilepsy Spinal muscular atrophy with progressive myoclonic epilepsy Printable PDF Open All Close All Enable Javascript ... boxes. Description Spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME) is a neurological condition that causes ...

  15. Crescimento inicial de mudas de Acacia mangium cultivadas em mantas de fibra de coco contendo substrato de lodo de esgoto

    Directory of Open Access Journals (Sweden)

    Rômulo Fredson Duarte

    2011-02-01

    Full Text Available O objetivo deste trabalho foi avaliar o crescimento inicial de mudas de Acacia mangium semeadas em "manta" de fibra de coco contendo substrato de lodo de esgoto. O delineamento experimental foi em blocos casualizados com 13 tratamentos e três repetições, distribuídos em esquema fatorial (6 x 2 + 1 com seis proporções de fibra de coco e resíduo agregante, combinados com substratos com e sem lodo de esgoto, mais o tratamento-controle (terra de subsolo. Foram avaliados o índice de velocidade de emergência (IVE, a percentagem de emergência (EM e a altura das plantas aos 40 e 60 dias após a emergência. O tratamento- controle apresentou melhores resultados em relação ao IVE e EM quando comparado com os tratamentos utilizando "manta" de fibra de coco e resíduo agregante. Não houve diferença entre o controle e os tratamentos com "mantas" em altura das plantas aos 40 e 60 dias. Não foram observadas interações entre o tipo de substrato utilizado no semeio e as diferentes proporções de fibra de coco na "manta". A presença de lodo no substrato não influenciou o IVE e a EM, contudo verificou-se que o substrato sem lodo de esgoto proporcionou maior crescimento em altura das plantas. O uso de "mantas" contendo 50 e 100% de fibra de coco proporcionou maior crescimento às mudas de acácia em condições de campo.

  16. Muscular Imbalance Correction in the Power Fitness Training

    OpenAIRE

    Olga E. Aftimichuk; Alexander V. Varvarich

    2013-01-01

    Muscular imbalance is one of the manifestations of pathological-biomechanical changes in muscular-skeletal system. It is the result of tonus-power imbalance of short and relaxed muscles. Muscle shortening is the most striking sign of muscular imbalance. Hypodynamia and passive lifestyle can cause such results. The paper justifies the experimental technique of women muscular imbalances correction by means of power training. Selection of exercises, weights and machines was made, taking into acc...

  17. Obtención de fibra dietética nutricional de valor agregado a partir de bagazo de caña

    OpenAIRE

    Licona Aguilar, Angeles Iveth

    2013-01-01

    La fibra dietética se reconoce cada vez más como un elemento importante para una nutrición sana; numerosas referencias respaldan esta aseveración en las que se ha demostrado no solo la importancia que la fibra tiene en la regulación de las funciones intestinales sino también para la prevención de algunas enfermedades. En este contexto, tiene sentido analizar la posibilidad de aprovechar la potencial utilización que brindan numerosos residuos agrícolas como fuente de fibra en una gran variedad...

  18. Rapid prototyping and evaluation of programmable SIMD SDR processors in LISA

    Science.gov (United States)

    Chen, Ting; Liu, Hengzhu; Zhang, Botao; Liu, Dongpei

    2013-03-01

    With the development of international wireless communication standards, there is an increase in computational requirement for baseband signal processors. Time-to-market pressure makes it impossible to completely redesign new processors for the evolving standards. Due to its high flexibility and low power, software defined radio (SDR) digital signal processors have been proposed as promising technology to replace traditional ASIC and FPGA fashions. In addition, there are large numbers of parallel data processed in computation-intensive functions, which fosters the development of single instruction multiple data (SIMD) architecture in SDR platform. So a new way must be found to prototype the SDR processors efficiently. In this paper we present a bit-and-cycle accurate model of programmable SIMD SDR processors in a machine description language LISA. LISA is a language for instruction set architecture which can gain rapid model at architectural level. In order to evaluate the availability of our proposed processor, three common baseband functions, FFT, FIR digital filter and matrix multiplication have been mapped on the SDR platform. Analytical results showed that the SDR processor achieved the maximum of 47.1% performance boost relative to the opponent processor.

  19. Compact laser interferometer for translation and tilt measurement as optical readout for the LISA inertial sensor

    Science.gov (United States)

    Schuldt, Thilo; Gohlke, Martin; Weise, Dennis; Johann, Ulrich; Peters, Achim; Braxmaier, Claus

    2007-10-01

    The space mission LISA (Laser Interferometer Space Antenna) aims at detecting gravitational waves in the frequency range 30 μ Hz to 1Hz. Free flying proof masses inside the satellites act as inertial sensors and represent the end mirrors of the interferometer. In the current baseline design, LISA utilizes an optical readout of the position and tilt of the proof mass with respect to the satellite housing. This readout must have ~ 5pm/√Hz sensitivity for the translation measurement (for frequencies above 2.8mHz with an ƒ -2 relaxation down to 30 μHz) and ~ 10 nrad/√Hz sensitivity for the tilt measurement (for frequencies above 0.1mHz with an ƒ -1 relaxation down to 30 μHz). The University of Applied Sciences Konstanz (HTWG) - in collaboration with Astrium GmbH, Friedrichshafen, and the Humboldt-University Berlin - therefore develops a highly symmetric heterodyne interferometer implementing differential wavefront sensing for the tilt measurement. We realized a mechanically highly stable and compact setup. In a second, improved setup we measured initial noise levels below 5 pm/√Hz and 10 nrad/√Hz, respectively, for frequencies above 10mHz.

  20. Principles, operations, and expected performance of the LISA Pathfinder charge management system

    Energy Technology Data Exchange (ETDEWEB)

    Ziegler, T [Astrium GmbH, 88039 Friedrichshafen (Germany); Fichter, W [iFR, Universitaet Stuttgart, Pfaffenwaldring 7a, 70569 Stuttgart (Germany); Schulte, M [Blackett Laboratory, Imperial College, Prince Consort Road, London SW7 2BZ (United Kingdom); Vitale, S, E-mail: tobias.ziegler@astrium.eads.ne [Department of Physics, University of Trento, 38050 Povo, Trento (Italy)

    2009-03-01

    The test masses of LISA Pathfinder are free flying and therefore not grounded to the spacecraft by a wire. Because of galactic cosmic rays, solar energetic particles, and unknown microscopic surface effects during initial test mass release, an unacceptable level of absolute charge might be present on the test masses. A charged test mass can endanger transition to high accuracy control modes which are required for science experiments. Furthermore, charged test masses introduce unwanted disturbance accelerations for example due to Coulomb interactions with surrounding conducting surfaces. The charge management system is designed to discharge the test masses up to a tolerable level of absolute charge such that the mission goal can be achieved. It is therefore an essential part of the experiments to be performed with the LISA Technology Package. The paper describes charge management tasks to be performed on board the spacecraft and summarizes the principles of charge measurement and discharge control. An overview of the experiment operations is given where the interconnection of operational charge management system modes and operational modes of the drag-free, suspension and attitude control system is considered. Simulated performance results are presented.

  1. LISA time-delay interferometry zero-signal solution: Geometrical properties

    International Nuclear Information System (INIS)

    Tinto, Massimo; Larson, Shane L.

    2004-01-01

    Time-delay interferometry (TDI) is the data processing technique needed for generating interferometric combinations of data measured by the multiple Doppler readouts available onboard the three Laser Interferometer Space Antenna (LISA) spacecraft. Within the space of all possible interferometric combinations TDI can generate, we have derived a specific combination that has zero response to the gravitational wave signal, and called it the zero-signal solution (ZSS). This is a two-parameter family of linear combinations of the generators of the TDI space, and its response to a gravitational wave becomes null when these two parameters coincide with the values of the angles of the source location in the sky. Remarkably, the ZSS does not rely on any assumptions about the gravitational waveform, and in fact it works for waveforms of any kind. Our approach is analogous to the data analysis method introduced by Guersel and Tinto in the context of networks of Earth-based, wideband, interferometric gravitational wave detectors observing in coincidence a gravitational wave burst. The ZSS should be regarded as an application of the Guersel and Tinto method to the LISA data

  2. Metal-amplified Density Assays, (MADAs), including a Density-Linked Immunosorbent Assay (DeLISA).

    Science.gov (United States)

    Subramaniam, Anand Bala; Gonidec, Mathieu; Shapiro, Nathan D; Kresse, Kayleigh M; Whitesides, George M

    2015-02-21

    This paper reports the development of Metal-amplified Density Assays, or MADAs - a method of conducting quantitative or multiplexed assays, including immunoassays, by using Magnetic Levitation (MagLev) to measure metal-amplified changes in the density of beads labeled with biomolecules. The binding of target analytes (i.e. proteins, antibodies, antigens) to complementary ligands immobilized on the surface of the beads, followed by a chemical amplification of the binding in a form that results in a change in the density of the beads (achieved by using gold nanoparticle-labeled biomolecules, and electroless deposition of gold or silver), translates analyte binding events into changes in density measureable using MagLev. A minimal model based on diffusion-limited growth of hemispherical nuclei on a surface reproduces the dynamics of the assay. A MADA - when performed with antigens and antibodies - is called a Density-Linked Immunosorbent Assay, or DeLISA. Two immunoassays provided a proof of principle: a competitive quantification of the concentration of neomycin in whole milk, and a multiplexed detection of antibodies against Hepatitis C virus NS3 protein and syphilis T. pallidum p47 protein in serum. MADAs, including DeLISAs, require, besides the requisite biomolecules and amplification reagents, minimal specialized equipment (two permanent magnets, a ruler or a capillary with calibrated length markings) and no electrical power to obtain a quantitative readout of analyte concentration. With further development, the method may be useful in resource-limited or point-of-care settings.

  3. Parasites and hepatic histopathological lesions in lisa (Mugil incilis from Totumo mash, North of Colombia

    Directory of Open Access Journals (Sweden)

    Jesús Olivero V.

    2013-03-01

    Full Text Available Objective. To assess the levels of parasitism by nematodes and trematodes, as well as the hepatic histopathological alterations present in Mugil incilis (Lisa from Totumo marsh, North of Colombia. Materials and methods. Between July 2004 and June 2005, 500 fish were collected at Totumo Marsh (75°16’W and 10°44´N, North of Colombia. Morphometric and parasitic parameters were determined for each specimen, and the hepatic histopathological status of the liver was assessed by analyzing liver slides stained with hematoxylin and eosin. Results. Nematode larvae isolated from Mugil incilis corresponded to Contracaecum spp. Parasite prevalence was 60.49%. Parasitic mean abundance and mean intensity were 4.8±1.05 and 7.02±1.49, nematodes per fish, respectively. The correlation between nematode mean abundance and fish length was significant and positive (r=0.525, p<0.0001, but negative for condition factor (r=-0.109, p=0.014. Hepatic histopathological analysis revealed the presence of encapsulated trematode larvae as the main finding. However, the presence of inflammation, granulomas, steatosis and necrosis, were also registered as secondary alterations. Conclusions. Lisas collected at Totumo Marsh are parasitized with nematodes and trematodes. These fish have different histopathological lesions in the liver tissue, being the most important the presence of trematode encapsulated cyst that generate inflammatory reactions, and negatively correlate with morphometric markers of fish health.

  4. Constraints on LISA Pathfinder's Self-Gravity: Design Requirements, Estimates and Testing Procedures

    Science.gov (United States)

    Armano, M.; Audley, H.; Auger, G.; Baird, J.; Binetruy, P.; Born, M.; Bortoluzzi, M.; Brandt, Nico; Bursi, Alessandro; Slutsky. J.; hide

    2016-01-01

    LISA Pathfinder satellite was launched on 3 December 2015 toward the Sun Earth first Lagrangian point (L1) where the LISA Technology Package (LTP), which is the main science payload, will be tested. LTP achieves measurements of differential acceleration of free-falling test masses (TMs) with sensitivity below 3 x 10(exp -14) m s(exp -2) Hz(exp - 1/2) within the 130 mHz frequency band in one dimension. The spacecraft itself is responsible for the dominant differential gravitational field acting on the two TMs. Such a force interaction could contribute a significant amount of noise and thus threaten the achievement of the targeted free-fall level. We prevented this by balancing the gravitational forces to the sub nm s(exp -2) level, guided by a protocol based on measurements of the position and the mass of all parts that constitute the satellite, via finite element calculation tool estimates. In this paper, we will introduce the gravitational balance requirements and design, and then discuss our predictions for the balance that will be achieved in flight.

  5. Simulation of the charging process of the LISA test masses due to solar flares

    International Nuclear Information System (INIS)

    Vocca, H; Grimani, C; Amico, P; Bosi, L; Marchesoni, F; Punturo, M; Travasso, F; Barone, M; Stanga, R; Vetrano, F; Vicere, A

    2004-01-01

    Cosmic-ray and solar high energy particles penetrate the LISA experiment test masses. Consequently, an electric charge accumulates in the bodies of the masses, generating spurious Coulomb forces between the masses and the surrounding electrodes. This process increases the noise level of the experiment. We have estimated the amount of charge deposited per second on the LISA test masses by solar flares and primary cosmic-ray protons at solar minimum. The simulation has been carried out with the Fluka Monte Carlo program. A simplified geometry for the experiment has been considered. We have found a net charging rate of 37 ± 1 e + /s for primary protons at solar minimum between 0.1 and 1000 GeV/n. The amount of charge released by a medium-strong solar flare, like that of 16 February 1984, is 10 732 ± 30 e + /s in the energy range 0.1-10 GeV/n. This value increases or decreases by approximately one order of magnitude for strong (weak) solar flares

  6. Carga limite para juntas mecânicas em laminados de fibra de carbono

    OpenAIRE

    Arthur Chaves de Mas Santacreu

    1989-01-01

    Neste trabalho são testadas várias juntas parafusadas com laminados de fibra de carbono. São investigadas as influências dos parâmetros geométricos e dos parâmetros de constituição do laminado no comportamento da curva carga versus deformação do furo carregado. Paralelamente é desenvolvido um modelo de elementos finitos linear elástico para calcular a deformação do furo carregado a partir das propriedades mecânicas do material e da geometria da junta. É proposto um critério de previsão de car...

  7. Science with the space-based interferometer eLISA. II. Gravitational waves from cosmological phase transitions

    International Nuclear Information System (INIS)

    Caprini, Chiara; Hindmarsh, Mark; Helsinki Univ.; Huber, Stephan

    2016-04-01

    We investigate the potential for the eLISA space-based interferometer to detect the stochastic gravitational wave background produced by strong first-order cosmological phase transitions. We discuss the resulting contributions from bubble collisions, magnetohydrodynamic turbulence, and sound waves to the stochastic background, and estimate the total corresponding signal predicted in gravitational waves. The projected sensitivity of eLISA to cosmological phase transitions is computed in a model-independent way for various detector designs and configurations. By applying these results to several specific models, we demonstrate that eLISA is able to probe many well-motivated scenarios beyond the Standard Model of particle physics predicting strong first-order cosmological phase transitions in the early Universe.

  8. Laserterapia de baixa intensidade na expressão de colágeno após lesão muscular cirúrgica Low-level laser therapy in the expression of collagen after muscular surgical injury

    Directory of Open Access Journals (Sweden)

    Flávia Fonseca Moreira

    2011-03-01

    Full Text Available A laserterapia é um procedimento utilizado em larga escala nas lesões musculoesqueléticas, devido as suas diversas propriedades, antiinflamatórias, cicatrizantes entre outras. Além disso, há tipos distintos de aparelhos de laser. Mesmo com os diversos modelos experimentais existentes na literatura, não há um consenso sobre a faixa de utilização, bem como o tipo de laser que promove melhor reparo no tecido muscular. Este estudo visa analisar os efeitos da laserterapia de baixa intensidade na expressão de colágeno após lesão muscular. Camundongos Swiss albinos (n=18 foram submetidos à lesão muscular cirúrgica e divididos em dois grupos, controle (C e teste (T. Os animais foram submetidos a uma irradiação diária de 5 J/cm² pelos lasers AsGaAl 830 nm e AsGa 904 nm e, em diferentes tempos de sacrifício (7 e 14 dias. Os resultados não demonstraram diferença estatística significativa na expressão de colágeno em ambos os grupos analisados. Contudo, os dados apontam que a dose de 5 J/cm² do laser AsGa 904 nm promoveu maior deposição de fibras colágenas após 14 dias de tratamento, sugerindo que a terapia seja efetiva na síntese de colágeno. Outros estudos experimentais, em humanos, devem ser propostos para maiores inferências sobre os resultados do laser no tratamento da lesão muscular.The laser therapy is a procedure utilized at long scale in the musculoskeletal injuries, due its anti-inflammatory and reparatory proprieties and others. Besides, there are differents types of laser equipments. Despites with the many experimental models at literature, there is no consensus about the range of application as well as the type of laser that promove of the best repair in muscular tissue. The aim of this study is to analyze the effects of the low level laser therapy in the expression of collagen after muscular injury. Mice Swiss albinos (n=18 were subjected to the muscular surgical injury and separated in two groups, control (C

  9. DESENVOLVIMENTO DE SORVETE ENRIQUECIDO COM FIBRAS DE LINHAÇA E LACTOBACILOS VIVOS E SUA VIABILIDADE

    Directory of Open Access Journals (Sweden)

    Marina Leopoldina Lamounier,

    2012-08-01

    Full Text Available Observa-se um aumento no número de consumidores conscientes que se preocupam em adquirir produtos de qualidade, que apresentam sabor e aparência agradáveis e são mais nutritivos e saudáveis. Dentre esses alimentos, se destacam os probióticos e as fibras que são comprovadamente benéficos à saúde. Este trabalho teve como objetivos desenvolver sorvete de ameixa enriquecido com fibras de linhaça e lactobacilos vivos, bem como verificar sua aceitação e viabilidade durante o período de validade. Foi utilizado Lactobacillus acidophilus como agente de fermentação do leite e sua viabilidade na mistura foi avaliada através das análises microbiológicas durante 0, 7, 14, 21 e 28 dias de estocagem. Os resultados obtidos mostraram que sorvete pode ser armazenado durante 28 dias a -18 ºC mantendo as suas características probióticas. Apesar de haver uma redução no número de células viáveis após o armazenamento, o sorvete apresentou no final desse período contagens médias de 1,9 x 107 UFC/g, estando de acordo com a legislação podendo, portanto ser considerado um alimento probiótico. A avaliação sensorial foi realizada por 50 provadores não treinados onde 91% aprovaram o produto e 76% declararam que comprariam o produto. Assim, demonstra-se a viabilidade de elaboração do sorvete adicionado de Lactobacillus acidophilus e linhaça.

  10. Cardiomyopathy in becker muscular dystrophy: Overview.

    Science.gov (United States)

    Ho, Rady; Nguyen, My-Le; Mather, Paul

    2016-06-26

    Becker muscular dystrophy (BMD) is an X-linked recessive disorder involving mutations of the dystrophin gene. Cardiac involvement in BMD has been described and cardiomyopathy represents the number one cause of death in these patients. In this paper, the pathophysiology, clinical evaluations and management of cardiomyopathy in patients with BMD will be discussed.

  11. Respiratory muscle training in Duchenne muscular dystrophy.

    OpenAIRE

    Rodillo, E; Noble-Jamieson, C M; Aber, V; Heckmatt, J Z; Muntoni, F; Dubowitz, V

    1989-01-01

    Twenty two boys with Duchenne muscular dystrophy were entered into a randomised double blind crossover trial to compare respiratory muscle training with a Triflow II inspirometer and 'placebo' training with a mini peak flow meter. Supine posture was associated with significantly impaired lung function, but respiratory muscle training showed no benefit.

  12. A Drosophila model for Duchenne muscular dystrophy

    NARCIS (Netherlands)

    Plas, Mariska Cathelijne van der

    2008-01-01

    Duchenne Muscular Dystrophy (DMD) is a severe X-linked disease characterized by progressive muscle wasting and sometimes mild mental retardation. The disease is caused by mutations in the dystrophin gene. DMD is correlated with the absence of Dp427, which is located along the sarcolemma in skeletal

  13. Duchenne muscular dystrophy models show their age

    OpenAIRE

    Chamberlain, Jeffrey S.

    2010-01-01

    The lack of appropriate animal models has hampered efforts to develop therapies for Duchenne muscular dystrophy (DMD). A new mouse model lacking both dystrophin and telomerase (Sacco et al., 2010) closely mimics the pathological progression of human DMD and shows that muscle stem cell activity is a key determinant of disease severity.

  14. What Are the Treatments for Muscular Dystrophy?

    Science.gov (United States)

    ... Child Neurology Society. (2005). Practice parameter: Corticosteroid treatment of Duchenne dystrophy. Neurology, 64 , 13-20. Retrieved June 22, 2012, ... Statement. (2004). Respiratory care of the patient with Duchenne muscular ... American Journal of Respiratory and Critical Care Medicine, 170, 456-465. ...

  15. Visuospatial Attention Disturbance in Duchenne Muscular Dystrophy

    Science.gov (United States)

    De Moura, Maria Clara Drummond Soares; do Valle, Luiz Eduardo Ribeiro; Resende, Maria Bernadete Dutra; Pinto, Katia Osternack

    2010-01-01

    Aim: The cognitive deficits present in the Duchenne muscular dystrophy (DMD) are not yet well characterized. Attention, considered to be the brain mechanism responsible for the selection of sensory stimuli, could be disturbed in DMD, contributing, at least partially, to the observed global cognitive deficit. The aim of this study was to…

  16. Brain Function in Duchenne Muscular Dystrophy

    Directory of Open Access Journals (Sweden)

    J. Gordon Millichap

    2002-02-01

    Full Text Available The role of dystrophin disorders in the CNS function of boys with Duchenne muscular dystrophy (DMD and the dystrophin-deficient mdx mouse, an animal model of DMD, is reviewed at the University of New South Wales, University of Sydney, Australia.

  17. Duchenne muscular dystrophy - a molecular service

    African Journals Online (AJOL)

    In 1987 a carrier detection and prenatal diagnostic service for. Duchenne muscular dystrophy using molecular technology was instituted at the Department of Human Genetics, Uni- versity of Cape Town, to serve affe.cted families in southern. Africa. DNA samples from 100 affected male subjects and. 350 of their relatives ...

  18. Skull development in the muscular dystrophic mouse

    DEFF Research Database (Denmark)

    Vilmann, H; Kirkeby, S; Moss, M L

    1989-01-01

    Roentgencephalometric tracings of skulls of 7-week-old normal and muscular dystrophic mice were compared. A marked size reduction of the dystrophic skulls relative to the normal ones was observed. However, the visceral parts of the dystrophic skull were more reduced in size than the neural parts....

  19. Hereditary muscular dystrophies and the heart

    NARCIS (Netherlands)

    Hermans, M. C. E.; Pinto, Y. M.; Merkies, I. S. J.; de Die-Smulders, C. E. M.; Crijns, H. J. G. M.; Faber, C. G.

    2010-01-01

    Cardiac disease is a common clinical manifestation of neuromuscular disorders, particularly of muscular dystrophies. Heart muscle cells as well as specialized conducting myocardial fibres may be affected by the dystrophic process. The incidence and nature of cardiac involvement vary with different

  20. Cardiac involvement in children with neuro-muscular disorders

    Directory of Open Access Journals (Sweden)

    E. N. Arkhipova

    2015-01-01

    Full Text Available Many inherited neuromuscular disorders include cardiac involvement as a typical clinical feature. Among the most common of them is the group of muscular dystrophies. Dilated cardiomyopathy, ventricular arrhythmias, atrial fibrillations, atrioventricular and intraventricular conduction abnormalities, and sudden cardiac death are well known pathological findings in Duchenne muscular dystrophies, myotonic dystrophy type I and 2, Emery-Dreifuss muscular dystrophies and different types of limb-girdle muscular dystrophies and other disorders. Detection of cardiac pathology in patients with different muscular dystrophies is possible with ECG, echocardiography and cardiovascular magnetic resonance imaging, which are recommended for screening and early cardioprotective treatment.

  1. EDITORIAL: Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008 Proceedings of the 7th International LISA Symposium, Barcelona, Spain, 16-20 June 2008

    Science.gov (United States)

    Lobo, Alberto; Sopuerta, Carlos F.

    2009-05-01

    In June 2006 the LISA International Science Team (LIST) accepted the bid presented by the Institut d'Estudis Espacials de Catalunya (IEEC) to host the 7th International LISA Symposium. This was during its 11th meeting at the University of Maryland, just before the 6th edition of the symposium started at NASA's Goddard Space Flight Center. The 7th International LISA Symposium took place in the city of Barcelona, Spain, 16-20 June, 2008, in the premises of CosmoCaixa, a modern science museum located in the hills near Tibidabo. Almost 240 delegates registered for the event, a record breaking figure compared to previous editions of the symposium. Many of the most renowned world experts in LISA, gravitational wave science, and astronomy, as well as engineers, attended LISA #7 and produced state of the art presentations, while everybody benefited from the opportunity to have live discussions during the week in a friendly environment. The programme included 31 invited plenary lectures in the mornings, and eight parallel sessions in the afternoons. These were classified into seven major areas of research: LISA Technology, LISA PathFinder, LISA PathFinder Data Analysis, LISA Data Analysis, Gravitational Wave Sources, Cosmology and Fundamental Physics with LISA and Other Gravitational Wave Detectors. Abstracts for 138 communications were received, from which a selection was made by the session convenors which would fit time constraints. Up to 63 posters completed the scientific programme. More details on the programme, including some of the talks, can be found at the symposium website:http://www.ice.cat/research/LISA_Symposium. There was, however, a remarkable add-on: Professor Clifford Will delivered a startling presentation to the general public, who completely filled the Auditori—the main conference room, 320 seats—and were invited to ask questions to the speaker who boldly guided them through the daunting world of Black Holes, Waves of Gravity, and other Warped Ideas

  2. Mejoramiento de las propiedades de tensión en WPC de LDPE: HIPS/fibra natural mediante entrecruzamiento con DCP

    Directory of Open Access Journals (Sweden)

    Arnoldo Emilio Delgado Tobón

    2014-06-01

    Full Text Available Fibra de Retamo Liso (telinemonspessulana fue mezclada en una matriz polimérica formada por: polietileno de baja densidad (LDPE y poliestireno de alto impacto (HIPS en relación 70:30 respectivamente. La fibra natural fue sometida a reducción de tamaño entre 1700 y 850 µm; se le realizó tratamiento superficial de mercerización; el contenido de humedad fue 0,17%. El análisis termo gravimétrico (TGA muestra que la fibra tratada tiene estabilidad de 200,53 °C. La elaboración del compuesto se realizó en mezclador interno y la técnica de obtención de las probetas fue mediante moldeo por compresión. Se evaluó el efecto del agente entrecruzante peróxido de dicumilo (DCP en compuestos con varios porcentajes de fibra: 0; 10; 25; 50 phr. La adición de DCP (1 phr en los compuestos, mejora significativamente las propiedades de tensión con respecto a similares concentraciones de fibra; sin embargo, esta diferencia en los valores de las propiedades disminuye progresivamente cuando la cantidad de fibra se aproxima a 50 phr. El aumento en la concentración de fibra afecta negativamente las propiedades de tensión, con excepción del Módulo de Elasticidad y la Resistencia a la Fluencia. La causa principal es originada por la baja adhesión interfacial fibra natural-matriz polimérica, claramente evidenciada en las imágenes SEM.

  3. A study of atriphos (ATP) action on muscular circulation in progressive muscular dystrophy by the radioactive xenon clearance technique

    International Nuclear Information System (INIS)

    Chakyrov, B.; Samardzhiev, A.

    1977-01-01

    The effect of intramuscularly and intravenously adminostered atriphos on the muscular circulation was studied with radioactive xenon in 12 children with progressive muscular dystrophy. After combined local intramuscular injection of ATP (atriphos) with the radioactive marker a 12-fold increment of muscular circulation ensues, lasting about 15 minutes. No vasodilatating effect on the muscular flow was oberved after intravenous injection of 20-40 mg of atriphos. It is believed that intramuscular administration of atriphos produced dilatation of capillaries and of the venous part of the muscular circulation. (author)

  4. Efeito do tratamento alcalino de fibras de Curauá sobre as propriedades de compósitos de matriz biodegradável

    Directory of Open Access Journals (Sweden)

    Lílian Vanessa Rossa Beltrami

    2014-06-01

    Full Text Available Neste trabalho avaliou-se a influência do tratamento alcalino das fibras de curauá, nas concentrações de 1, 5 e 10%(m/v de NaOH, nas propriedades dos compósitos com matriz de PHBV e 20% m/m de fibras de curauá. Os compósitos foram moldados por extrusão e injeção e avaliadas suas as propriedades morfológicas, térmicas e mecânicas. Os resultados de FTIR mostraram que o tratamento alcalino promoveu modificações na estrutura das fibras de curauá, comprovadas pela remoção da hemicelulose e da lignina, evidenciadas pela ausência das bandas típicas destes compostos. Nos compósitos com fibras de curauá tratadas com solução de NaOH na concentração de 5% apresentaram um aumento de 30% na resistência à flexão e 12% na resistência ao impacto, quando comparados aos compósitos com fibras sem tratamento. Estes resultados indicam que o tratamento alcalino promoveu uma melhoria na adesão das fibras na matriz, o que melhorou significativamente as propriedades mecânicas dos compósitos.

  5. The low emittance 2.5 GeV synchrotron light source LISA

    International Nuclear Information System (INIS)

    Einfeld, D.; Hormes, J.; Husmann, D.

    1992-01-01

    LISA, a Light source for Industrial and Scientific Applications, has been proposed. Due to the intention to use the source above all for the LIGA (Lithographie, Galvanik, Abformtechnik) method to produce micromechanical structures, the critical wavelength of the synchrotron radiation spectrum is foreseen to be 0.2 nm. Therefore, the electron energy and the field strength of the ring dipoles have been chosen to be 2.5 GeV and 1.5 T, respectively. It is proposed to make use of a modified 'quadrupole ben achromat' (QBA) lattice. The novel feature of this lattice is the application of two types of bending magnets of different lengths, i.e. different bending angels. (author) 9 refs.; 6 figs.; 1 tab

  6. Metaphors Expressing Emotions in Lisa Kleypas’s Rainshadow Road Novel

    Directory of Open Access Journals (Sweden)

    Novi Liana Ko

    2014-05-01

    Full Text Available Metaphors have been always interesting to explore since they are able to represent many things, one of which is feelings. Article examined the metaphorical sentences which expressed emotions found in Lisa Kleypas’s the Rainshadow Road. Library research was conducted to find the kinds of emotions which were expressed by the metaphorical sentences. It was also done to figure out what the metaphors refered to. Another objective was to reveal the most dominant emotion which appeared through the metaphors expressed in the novel. The analysis used metaphor theory to compare the dictionary meaning and the metaphorical one. The result shows that there are various emotions which are expressed through the metaphorical sentences. Happiness is found as the most dominant emotion which appears in the novel.

  7. Actuation stability test of the LISA pathfinder inertial sensor front-end electronics

    Science.gov (United States)

    Mance, Davor; Gan, Li; Weber, Bill; Weber, Franz; Zweifel, Peter

    In order to limit the residual stray forces on the inertial sensor test mass in LISA pathfinder, √ it is required that the fluctuation of the test mass actuation voltage is within 2ppm/ Hz. The actuation voltage stability test on the flight hardware of the inertial sensor front-end electronics (IS FEE) is presented in this paper. This test is completed during the inertial sensor integration at EADS Astrium Friedrichshafen, Germany. The standard measurement method using voltmeter is not sufficient for verification, since the instrument low frequency √ fluctuation is higher than the 2ppm/ Hz requirement. In this test, by using the differential measurement method and the lock-in amplifier, the actuation stability performance is verified and the quality of the IS FEE hardware is confirmed by the test results.

  8. Inference on white dwarf binary systems using the first round Mock LISA Data Challenges data sets

    International Nuclear Information System (INIS)

    Stroeer, Alexander; Veitch, John; Roever, Christian; Bloomer, Ed; Clark, James; Christensen, Nelson; Hendry, Martin; Messenger, Chris; Meyer, Renate; Pitkin, Matthew; Toher, Jennifer; Umstaetter, Richard; Vecchio, Alberto; Woan, Graham

    2007-01-01

    We report on the analysis of selected single source data sets from the first round of the mock LISA data challenges (MLDC) for white dwarf binaries. We implemented an end-to-end pipeline consisting of a grid-based coherent pre-processing unit for signal detection and an automatic Markov Chain Monte Carlo (MCMC) post-processing unit for signal evaluation. We demonstrate that signal detection with our coherent approach is secure and accurate, and is increased in accuracy and supplemented with additional information on the signal parameters by our Markov Chain Monte Carlo approach. We also demonstrate that the Markov Chain Monte Carlo routine is additionally able to determine accurately the noise level in the frequency window of interest

  9. Auxiliary functions of the LISA laser link: ranging, clock noise transfer and data communication

    International Nuclear Information System (INIS)

    Heinzel, Gerhard; Esteban, Juan Jose; Barke, Simon; Otto, Markus; Wang Yan; Garcia, Antonio F; Danzmann, Karsten

    2011-01-01

    The Laser Interferometer Space Antenna (LISA) is required to reduce two important noise sources by post-processing on the ground using time-delay interferometry (TDI): phase noise of the on-board reference clocks and laser frequency noise. To achieve the desired suppression, the TDI algorithm needs measurements of the differential clock noise between any two spacecraft and inter-spacecraft ranging measurements with at least 1 m accuracy, which is beyond the precision of ground-based measurements for deep space missions. Therefore, we need on-board measurements by transmitting clock noise and ranging information between the spacecraft as auxiliary functions of the laser link. This paper reports our current experimental results in clock noise transfer and ranging for noise subtraction via post-processing as well as additional data transfer.

  10. Massive Black Hole Mergers: Can we see what LISA will hear?

    Science.gov (United States)

    Centrella, Joan

    2009-01-01

    Coalescing massive black hole binaries are formed when galaxies merge. The final stages of this coalescence produce strong gravitational wave signals that can be detected by the space-borne LISA. When the black holes merge in the presence of gas and magnetic fields, various types of electromagnetic signals may also be produced. Modeling such electromagnetic counterparts requires evolving the behavior of both gas and fields in the strong-field regions around the black holes. We have taken a first step towards this problem by mapping the flow of pressureless matter in the dynamic, 3-D general relativistic spacetime around the merging black holes. We report on the results of these initial simulations and discuss their likely importance for future hydrodynamical simulations.

  11. eLISA Telescope In-field Pointing and Scattered Light Study

    Science.gov (United States)

    Livas, J.; Sankar, S.; West, G.; Seals, L.; Howard, J.; Fitzsimons, E.

    2017-05-01

    The orbital motion of the three spacecraft that make up the eLISA Observatory constellation causes long-arm line of sight variations of approximately ± one degree over the course of a year. The baseline solution is to package the telescope, the optical bench, and the gravitational reference sensor (GRS) into an optical assembly at each end of the measurement arm, and then to articulate the assembly. An optical phase reference is exchanged between the moving optical benches with a single mode optical fiber (“backlink” fiber). An alternative solution, referred to as in-field pointing, embeds a steering mirror into the optical design, fixing the optical benches and eliminating the backlink fiber, but requiring the additional complication of a two-stage optical design for the telescope. We examine the impact of an in-field pointing design on the scattered light performance.

  12. A constrained Metropolis-Hastings search for EMRIs in the Mock LISA Data Challenge 1B

    International Nuclear Information System (INIS)

    Gair, Jonathan R; Porter, Edward; Babak, Stanislav; Barack, Leor

    2008-01-01

    We describe a search for the extreme-mass-ratio inspiral sources in the Round 1B Mock LISA Data Challenge data sets. The search algorithm is a Monte Carlo search based on the Metropolis-Hastings algorithm, but also incorporates simulated, thermostated and time annealing, plus a harmonic identification stage designed to reduce the chance of the chain locking onto secondary maxima. In this paper, we focus on describing the algorithm that we have been developing. We give the results of the search of the Round 1B data, although parameter recovery has improved since that deadline. Finally, we describe several modifications to the search pipeline that we are currently investigating for incorporation in future searches

  13. Bell's palsy: the answer to the riddle of Leonardo da Vinci's 'Mona Lisa'.

    Science.gov (United States)

    Maloney, W J

    2011-05-01

    The smile of the famed portrait 'The Mona Lisa' has perplexed both art historians and researchers for the past 500 years. There has been a multitude of theories expounded to explain the nature of the model's enigmatic smile. The origin of the model's wry smile can be demonstrated through a careful analysis of both documented facts concerning the portrait--some gathered only recently through the use of modern technology--and a knowledge of the clinical presentation of Bell's palsy. Bell's palsy is more prevalent in women who are either pregnant or who have recently given birth. This paper postulates that the smile of the portrait's model was due to Leonardo da Vinci's anatomically precise representation of a new mother affected by Bell's palsy subsequent to her recent pregnancy.

  14. Selective metallization of polymers using laser induced surface activation (LISA)—characterization and optimization of porous surface topography

    DEFF Research Database (Denmark)

    Zhang, Yang; Hansen, Hans Nørgaard; De Grave, Arnaud

    2011-01-01

    Laser induced selective activation (LISA) is a molded interconnected devices technique for selective metallization of polymers. On the working piece, only the laser-machined area can be metalized in the subsequent plating. The principle of the technology is introduced. Surface analysis was perfor...

  15. Simple Enough--Even for Web Virgins: Lisa Mitten's Access to Native American Web Sites. Web Site Review Essay.

    Science.gov (United States)

    Belgarde, Mary Jiron

    1998-01-01

    A mixed-blood Mohawk urban Indian and university librarian, Lisa Mitten provides access to Web sites with solid information about American Indians. Links are provided to 10 categories--Native nations, Native organizations, Indian education, Native media, powwows and festivals, Indian music, Native arts, Native businesses, and Indian-oriented home…

  16. Search for a stochastic gravitational-wave signal in the second round of the Mock LISA Data Challenges

    International Nuclear Information System (INIS)

    Robinson, E L; Vecchio, A; Romano, J D

    2008-01-01

    The analysis method currently proposed to search for isotropic stochastic radiation with the Laser Interferometer Space Antenna (LISA) relies on the combined use of two LISA channels, one of which is insensitive to gravitational waves, such as the symmetrized Sagnac. For this method to work, it is essential to know how the instrumental noise power in the two channels are related to one another; however, no quantitative estimates of this key information are available to date. The purpose of our study is to assess the performance of the symmetrized Sagnac method for different levels of prior information regarding the instrumental noise. We develop a general approach in the framework of Bayesian inference and an end-to-end analysis algorithm based on Markov chain Monte Carlo methods to compute the posterior probability density functions of the relevant model parameters. We apply this method to data released as part of the second round of the Mock LISA Data Challenges. For the selected (and somewhat idealized) example cases considered here, we find that for a signal whose amplitude dominates the instrumental noise by a factor ∼25, a prior uncertainty of a factor ∼2 in the ratio between the power of the instrumental noise contributions in the two channels allows for the detection of isotropic stochastic radiation. More importantly, we provide a framework for more realistic studies of LISA's performance and development of analysis techniques in the context of searches for stochastic signals

  17. Playing Harry Potter: Essays and interviews on fandom and performance, edited by Lisa S. Brenner [book review

    Directory of Open Access Journals (Sweden)

    Abigail De Kosnik

    2016-09-01

    Full Text Available Review of Lisa S. Brenner, editor. Playing Harry Potter: Essays and interviews on fandom and performance. Jefferson, NC: McFarland, 2015, paperback, $29.95 (238p ISBN 978-0-7864-9657-0, e-book $14.43 (5374 KB ISBN 978-1-4766-2136-4, ASIN B012E9G0R6.

  18. CONSUMO DE FIBRA DIETÉTICA EN LACTANTES MENORES DE 2 AÑOS Y ESTREÑIMIENTO FUNCIONAL

    OpenAIRE

    Carlos Alberto Velasco Benítez; Sandra Carolina Giraldo Lora

    2014-01-01

    Introducción: La inclusión de la fibra dietética (FD), tiene múltiples beneficios sobre la salud del ser humano; sin embargo, en pediatría, existen grandes brechas concernientes a la relación de fibra y estreñimiento. Objetivo: Describir el hábito intestinal en lactantes . Se tuvo en cuenta la alimentación con leche materna, el tiempo de inicio de alimentación complementaria y el antecedente de madre o cuidador con EF. Los resultados son expresados como X±DS. El análisis estadístico incluyó X...

  19. Utilização de pós residuais e fibra de sisal em blocos de concreto

    OpenAIRE

    Indara Soto Izquierdo

    2015-01-01

    A pesquisa tem como enfoque fundamental a aplicação de novos materiais alternativos para uma construção sustentável. Pós residuais, provenientes do resíduo orgânico e do setor mineral, e fibras de sisal constituem bons exemplos de materiais não convencionais. Dessa forma, o objetivo principal foi avaliar a incorporação dos pós residuais e da fibra de sisal no concreto para a fabricação de blocos de concreto e elementos de alvenaria. Foram estudados três relações cimento: agregado, de 1:15, 1:...

  20. Theory and modelling of the magnetic field measurement in LISA PathFinder

    Energy Technology Data Exchange (ETDEWEB)

    Diaz-Aguilo, M; Garcia-Berro, E [Departament de Fisica Aplicada, Universitat Politecnica de Catalunya, c/Esteve Terrades, 5, 08860 Castelldefels (Spain); Lobo, A, E-mail: marc.diaz.aguilo@fa.upc.ed [Institut d' Estudis Espacials de Catalunya, c/Gran Capita 2-4, Edif. Nexus 104, 08034 Barcelona (Spain)

    2010-02-07

    The magnetic diagnostics subsystem of the LISA Technology Package (LTP) on board the LISA PathFinder (LPF) spacecraft includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at their respective positions. However, their readouts do not provide a direct measurement of the magnetic field at the positions of the test masses, and hence an interpolation method must be designed and implemented to obtain the values of the magnetic field at these positions. However, such an interpolation process faces serious difficulties. Indeed, the size of the interpolation region is excessive for a linear interpolation to be reliable while, on the other hand, the number of magnetometer channels do not provide sufficient data to go beyond the linear approximation. We describe an alternative method to address this issue, by means of neural network algorithms. The key point in this approach is the ability of neural networks to learn from suitable training data representing the behaviour of the magnetic field. Despite the relatively large distance between the test masses and the magnetometers, and the insufficient number of data channels, we find that our artificial neural network algorithm is able to reduce the estimation errors of the field and gradient down to levels below 10%, a quite satisfactory result. Learning efficiency can be best improved by making use of data obtained in on-ground measurements prior to mission launch in all relevant satellite locations and in real operation conditions. Reliable information on that appears to be essential for a meaningful assessment of magnetic noise in the LTP.

  1. Theory and modelling of the magnetic field measurement in LISA PathFinder

    International Nuclear Information System (INIS)

    Diaz-Aguilo, M; Garcia-Berro, E; Lobo, A

    2010-01-01

    The magnetic diagnostics subsystem of the LISA Technology Package (LTP) on board the LISA PathFinder (LPF) spacecraft includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at their respective positions. However, their readouts do not provide a direct measurement of the magnetic field at the positions of the test masses, and hence an interpolation method must be designed and implemented to obtain the values of the magnetic field at these positions. However, such an interpolation process faces serious difficulties. Indeed, the size of the interpolation region is excessive for a linear interpolation to be reliable while, on the other hand, the number of magnetometer channels do not provide sufficient data to go beyond the linear approximation. We describe an alternative method to address this issue, by means of neural network algorithms. The key point in this approach is the ability of neural networks to learn from suitable training data representing the behaviour of the magnetic field. Despite the relatively large distance between the test masses and the magnetometers, and the insufficient number of data channels, we find that our artificial neural network algorithm is able to reduce the estimation errors of the field and gradient down to levels below 10%, a quite satisfactory result. Learning efficiency can be best improved by making use of data obtained in on-ground measurements prior to mission launch in all relevant satellite locations and in real operation conditions. Reliable information on that appears to be essential for a meaningful assessment of magnetic noise in the LTP.

  2. Elimination of vibrio cholerae in lisa fillets (Mugil cephalus) by gamma radiation

    International Nuclear Information System (INIS)

    Torres, Z.

    1999-03-01

    The elimination of Vibrio cholerae 01 biotype El Tor (1,87 8 cuf/g) in fresh lisa fillets (Mugil cephalus) with radiation doses of 0 and 0,5 kGy was investigated. Furthermore, in order to evaluate physical, chemical and sensory changes, doses of 1,2,3 and 4 kGy were applied to non inoculated fillets of lisa. Finally, D 10 for Vibrio cholerae was determined in a saline suspension (5,2x10 8 cfu/ml) based on the Most Probable Number (MPN) method and radiation doses of 0,5, 0,75, 1,0, 1,25 and 1,5 kGy. D value found in a 1,87 8 cfu/g concentration of fillet was 0,13 kGy. Humidity, protein, fat and ash contents were not affected significantly and remained around 73 to 75,5, 3,8 to 4,2 and 1% respectively. Control samples showed a 'drip' variation ranging between 0,82 and 0,88% and a N-BVT variation between 1,77 and 1,56, 0,89 and 1,99, 2,13 and 2,47, 1,86 and 2,10%, and a N-BVT variation between 17,79 and 30,16, 16,37 and 26,88 16,33 and 25,12, 15,31 and 33,54 mg N/100 g, respectively. The highest life span for the appearance characteristic was obtained by control samples (23 days) and the lowest by samples radiated at 3 and 4 kGy (28 days). 4 kGy dose resulted in organoleptic changes perceived by panelists during tasting of cooked fish. D 10 found in a saline suspension was 0,13 kGy

  3. Editorial. Special issue of Classical and Quantum Gravity on the proceedings of the 4th international LISA symposium

    International Nuclear Information System (INIS)

    Finn, Lee Samuel

    2003-01-01

    The 4th International LISA Symposium was held at the National Science Foundation Physics Frontier Center for Gravitational Wave Physics at The Pennsylvania State University on 19-24 July 2002. This special issue of Classical and Quantum Gravity is the proceedings of this meeting. LISA - the Laser Interferometer Space Antenna - is part of an international effort to open a new window on the universe. Not all things radiate light, but everything gravitates. Observations of the gravitational waves radiated by black holes and compact binary star systems, in our galaxy and beyond, can reveal details about these systems and their environments that are otherwise inaccessible. The international effort, of which LISA is a part, includes ground-based detectors, and the relationship between LISA and its ground-based detector 'cousins' was an important theme for this Symposium. LISA will observe gravitational waves in the 0.1 mHz to 0.1 Hz band, complementing observations made by ground-based detectors in the 10 Hz to several KHz band. Together they will explore nearly six decades of bandwidth in the gravitational-wave sky. LISA in particular will observe the gravitational waves radiated by the coalescence of black holes at the centres of colliding galaxies, and the inspiral of compact neutron stars or stellar-mass black holes onto these black holes, virtually anywhere in the universe. It will take a census of neutron star or close white dwarf binaries in our own galaxy and observe the formation of large black holes from the very first structures to form and collapse in our universe. In doing all these things, it will shed new 'light' on the first structures to form in the universe, explore the evolution of galaxies and the roles that black holes play in their structure, test relativity near the 'edges' of a black hole, and deepen our understanding of stellar and binary system evolution. A successful conference - and this LISA Symposium, like its predecessors, was very

  4. Método para la formulación de hormigones de fibras metálicas

    Directory of Open Access Journals (Sweden)

    Serna Ros, Pedro

    1984-06-01

    Full Text Available In the work we are presenting, we have set ourselves the target of determining a practical method for ascertaining the dosage of fibrous concrete. To do this, as in any problem regarding dosage, we shall start from the possibilities of supply, which will be conditioned by the nature of the aggregates to be used, of certain technical restrictions imposed by the admixtures and of the carrying out requirements which will set the concrete workability. The first part of our study amounts to determining the optimal percentages for each aggregate and the water-cement ratio, starting with the dosage of cement established initially and for each fibre content proposed. In the second part, we shall develop the study of acceptable limits of fibre content, in order to prevent 'balls of fibre' from forming.

    En los trabajos que presentamos nos hemos planteado el objetivo de determinar un método práctico de dosificación de hormigones de fibras. Para ello partiremos, como en cualquier problema de dosificación, de unas posibilidades de suministro que nos condicionarán la naturaleza de los áridos a utilizar, de unas limitaciones técnicas impuestas por los aditivos, y de unas necesidades de puesta en obra que nos fijarán la trabajabilidad del hormigón. La primera parte de nuestro trabajo se reduce a determinar, a partir de la dosificación en cemento fijada inicialmente, y para cada contenido en fibras propuesto, los porcentajes óptimos de cada uno de los áridos y la relación agua/cemento. En la segunda parte desarrollaremos el estudio de los límites admisibles del contenido en fibras, para evitar la formación de "pelotas de fibras".

  5. Neuropatia experimental por DDT: análise de nervo por microdissecção de fibras

    Directory of Open Access Journals (Sweden)

    Edison Matos Nóvak

    1984-09-01

    Full Text Available Estudou-se o nervo gênito-femural do rato albino submetido a intoxicação crônica por DDT, administrado por 180 dias na dose de 5 mg/kg de peso via oral. Os resultados mostraram proporção anormal de fibras tipo C, sendo sugerido ocorrer degeneração tipo axonal determinada pelo DDT.

  6. Studio dei fattori che influenzano la digeribilità della fibra nella bovina da latte: approcci dinamici

    OpenAIRE

    Bonfante, Elena

    2017-01-01

    I ruminanti sono altamente specializzati nella digestione della fibra. In condizioni di ottima funzionalità digestiva, sono le particelle di foraggio ad essere trattenute per lungo tempo nel rumine dove possono essere degradate dai batteri cellulosolitici. Nonostante queste conoscenze, la stima della degradabilità ruminale delle porzioni potenzialmente degradabili delle fibre è stata notevolmente sottostimata da taluni modelli dinamici di razionamento. Studi più recenti realizzati da Kriz...

  7. COMPORTAMIENTO DEL CONCRETO REFORZADO CON FIBRAS DE ACERO ZP-306 SOMETIDO A ESFUERZOS DE COMPRESIÓN

    Directory of Open Access Journals (Sweden)

    Lina P. Gallo-Arciniegas

    2013-01-01

    Full Text Available En Colombia, el uso del concreto reforzado con fibras de acero (CRFA es muy limitado, debido a que en el país no existe suficiente evidencia experimental y requisitos reglamentarios al respecto. En el artículo se presentan los resultados de una investigación experimental y analítica sobre el comportamiento del CRFA elaborado con fibras ZP-306, sometidas a esfuerzos de compresión. El estudio involucra la revisión y discusión de los modelos disponibles en la literatura, así como un programa experimental que incluye el ensayo de 48 especímenes. A partir de un análisis de regresión de los datos medidos, se proponen ecuaciones para estimar las principales propiedades mecánicas del CRFA, tales como resistencia a compresión, módulo de elasticidad y relación de Poisson. Las ecuaciones correlacionan las propiedades mecánicas con las principales características de las fibras de acero, tales como dosificación y relación de aspecto.

  8. Importância da fibra na nutrição de coelhos Importance of fibre in rabbit nutrition

    Directory of Open Access Journals (Sweden)

    Alexandra del Pilar Naranjo Herrera

    2001-06-01

    Full Text Available Os coelhos, por serem herbívoros não ruminantes, podem ser alimentados com considerável quantidade de alimentos fibrosos. No entanto, não apresentam eficiência tão grande para utilizar essa fibra sendo, nesse aspecto, inferior aos ruminantes e, inclusive, aos suínos. Por outro lado, a fibra, apesar de seu escasso valor nutritivo, apresenta valor lastre, sendo importante, pois, na regulação do trânsito da digesta e na prevenção de distúrbios digestivos. Assim, o objetivo deste artigo é revisar alguns aspectos da composição química da fibra e de sua digestão pelos coelhos, bem como a sua relação com outros nutrientes da dieta, como proteína e energia.Rabbits are monogastric herbivorous that intake quantity significative of fibrous feed. However they not show efficiency to degrate this fibre, being less capacity, in this aspect, that ruminants and inclusively, of the swine. For other hand, the fibre have ballast value, being important in the transit digestive regulation and prevention of digestive disturb. Thus, the objetive of this paper is to review some aspects of chemistry composition of fibre and it's digestion for rabbits and it's relation with other components of diet like protein and energy.

  9. Muscular cysticercosis: Case report and imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Olmo, Neide Regina Simoes; Fiorio, Ulysses Ferreira; Clemente, Marcel Andreazza, E-mail: neideolmo@yahoo.com.br [Clinica Mult Imagem, Santos, SP (Brazil); Bastos, Eder Amaral [Universidade Metropolitana de Santos (UNIMES), Santos, SP (Brazil); Mendes, Gustavo Gomes [AC Camargo Cancer Center, Sao Paulo, SP (Brazil)

    2016-11-15

    Cysticercosis is a parasitic disease caused by a worm of the Cestoda class. The most prevalent form affects the nervous system. This case report is from a 78-year old female patient evaluated at Clinica Mult Imagem, in the city of Santos, Brazil, who presented a form of the disease that differed from the classic neurocysticercosis, in this case muscular cysticercosis. This and other forms of manifestation justify further studies to ensure adequate recognition, diagnosis and treatment of this parasitic disease. (author)

  10. Defective myoblasts identified in Duchenne muscular dystrophy.

    OpenAIRE

    Blau, H M; Webster, C; Pavlath, G K

    1983-01-01

    A defect in the proliferative capacity of satellite cells, mononucleated precursors of mature muscle fibers, was found in clonal analyses of cells cultured from Duchenne muscular dystrophy (DMD) patients. The total yield of myoblasts per gram of muscle biopsy was decreased to 5% of normal. Of the DMD myoblast clones obtained, a large proportion contained a morphological class of flat distended cells that had an increased generation time and ceased to proliferate beyond 100-1,000 cells but cou...

  11. Intra-muscular hemangioma: A review

    Directory of Open Access Journals (Sweden)

    Shruti Nayak

    2014-01-01

    Full Text Available Intra-muscular hemangiomas (IMH are relatively uncommon benign vascular tumors, which account for less than 1% of all hemangiomas. IMH may be presented as a perceived sporting injury. Diagnosis of this lesion is important not only because of its rarity, but also due to dangers posed by misdiagnosis and mismanagement. They must be considered in the differential diagnosis of unexplained pain and swelling in muscles. IMH occurring in the oral cavity is reviewed below.

  12. Urological manifestations of Duchenne muscular dystrophy.

    Science.gov (United States)

    Askeland, Eric J; Arlen, Angela M; Erickson, Bradley A; Mathews, Katherine D; Cooper, Christopher S

    2013-10-01

    Duchenne muscular dystrophy is a dystrophinopathy affecting males that is associated with multiple organ system complications. To our knowledge urological complications of Duchenne muscular dystrophy have been described only anecdotally to date. We reviewed the medical charts of 135 patients with Duchenne or Duchenne-Becker muscular dystrophy for demographics and disease progression, urological diagnoses, intervention and followup. Of 135 patients 67 (50%) had at least 1 documented urological diagnosis and 38 (28%) had multiple manifestations. Lower urinary tract symptoms were the most common urological diagnosis (32% of patients). Survival analysis revealed a median age at onset of lower urinary tract symptoms of 23 years (95% CI 17.7-23.9). Intervention was required in 12 patients (9%), most commonly due to nephrolithiasis. Urological morbidity increased with Duchenne muscular dystrophy progression when stratified by clinical progression. Lower urinary tract symptoms were more common in nonambulatory patients (40.7% vs 19%, p = 0.007), those with a diagnosis of scoliosis (44% vs 19.7%, p = 0.003) and/or scoliosis spine surgery (60% vs 22%, p <0.001), and those on invasive respiratory support (53% vs 29%, p = 0.046). Likewise, nephrolithiasis was more common in nonambulatory patients (10% vs 0%, p = 0.017), those with scoliosis (12% vs 0%, p = 0.004) and/or scoliosis spine surgery (20% vs 1%, p <0.001), and those on invasive respiratory support (29% vs 3%, p <0.001). Only 28% of patients with a urological manifestation were referred to urology. As these patients transition into adolescence and adulthood, the increased prevalence of urological manifestations warrants increased awareness and referral to urologists. Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  13. Disability and Survival in Duchenne Muscular Dystrophy

    OpenAIRE

    Kohler, M; Clarenbach, C F; Bahler, C; Brack, T; Russi, E W; Bloch, K E

    2009-01-01

    BACKGROUND: Duchenne muscular dystrophy (DMD) leads to progressive impairment of muscle function, respiratory failure and premature death. Longitudinal data on the course of physical disability and respiratory function are sparse. OBJECTIVES: To prospectively assess physical impairment and disability, respiratory function and survival in DMD patients over several years in order to describe the course of the disease with current care. METHODS: In 43 patients with DMD, aged 5-35 years, yearly a...

  14. Comportamiento a tracción de cementos reforzados con fibras de vidrio

    Directory of Open Access Journals (Sweden)

    Sánchez Paradela, M. Laura

    1991-06-01

    Full Text Available Glassfibre Reinforced Cement (GRC is a composite material widely used in the field of building construction. It offers multiple applications due to its high strength as well as fire and corrosoón resistance. However, it degradates with time, affecting its mechanical properties, mainly its ductility, becoming progressively brittle and cracking under low deformations. Therefore, with the aim of predicting the mechanical behaviour of the material, both at short time and long time, a wide experimental program has been carried out, testing fresh material as well as aged material. A high number of tensile tests have been performed, using GRC specimens with different kind of fibres and different manufacturing processes for comparison of results. It must be pointed out that it is the first time that tensile tests of GRC specimens have been carried out in Spain.

    El cemento reforzado con fibras de vidrio (GRC es un material compuesto que se viene utilizando ampliamente en el campo de la Construcción. Presenta múltiples aplicaciones debido a sus buenas propiedades resistentes y de protección frente al fuego y la corrosión. Sin embargo, sufre un deterioro con el tiempo, que afecta a sus propiedades mecánicas, principalmente a su ductilidad, volviéndose frágil y agrietándose bajo pequeñas deformaciones. Por tal motivo y con el fin de predecir el comportamiento mecánico del material a corto y a largo plazo, se ha desarrollado un extenso programa experimental, empleando tanto material joven como envejecido. Se han realizado numerosos ensayos de tracción directa, utilizando probetas de GRC con diversos tipos de fibras y empleando distintos métodos de fabricación para una comparación de resultados. Es la primera vez que se realizan ensayos de tracción directa en España sobre probetas de GRC.

  15. Proximal spinal muscular atrophy: current orthopedic perspective

    Directory of Open Access Journals (Sweden)

    Haaker G

    2013-11-01

    Full Text Available Gerrit Haaker, Albert Fujak Department of Orthopaedic Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany Abstract: Spinal muscular atrophy (SMA is a hereditary neuromuscular disease of lower motor neurons that is caused by a defective "survival motor neuron" (SMN protein that is mainly associated with proximal progressive muscle weakness and atrophy. Although SMA involves a wide range of disease severity and a high mortality and morbidity rate, recent advances in multidisciplinary supportive care have enhanced quality of life and life expectancy. Active research for possible treatment options has become possible since the disease-causing gene defect was identified in 1995. Nevertheless, a causal therapy is not available at present, and therapeutic management of SMA remains challenging; the prolonged survival is increasing, especially orthopedic, respiratory and nutritive problems. This review focuses on orthopedic management of the disease, with discussion of key aspects that include scoliosis, muscular contractures, hip joint disorders, fractures, technical devices, and a comparative approach of conservative and surgical treatment. Also emphasized are associated complications including respiratory involvement, perioperative care and anesthesia, nutrition problems, and rehabilitation. The SMA disease course can be greatly improved with adequate therapy with established orthopedic procedures in a multidisciplinary therapeutic approach. Keywords: spinal muscular atrophy, scoliosis, contractures, fractures, lung function, treatment, rehabilitation, surgery, ventilation, nutrition, perioperative management

  16. Management of myocardial damage in muscular dystrophy

    International Nuclear Information System (INIS)

    Tamura, Takuhisa

    2011-01-01

    Heart failure (HF) is a fatal complication in many muscular dystrophy cases and has become the most common cause of death in Duchenne muscular dystrophy (DMD) since 2001. HF deaths in DMD occur in young patients and increase, along with respiratory failure, in older patients. Managing HF, therefore, is the most important component of DMD treatment. Management of HF is necessary in DMD patients of all ages because myocardial damage progresses regardless of age and disability. Electrocardiography, echocardiography, myocardial single-photon emission computed tomography (SPECT), and natriuretic peptides are used for the diagnosis of myocardial damage and chronic HF. Tissue Doppler echocardiography is in particularly useful for early detection of minute myocardial damage and dysfunction in DMD. The first-line drugs for chronic HF are angiotensin-converting enzyme inhibitors, and the prognosis of DMD patients has been improved using these drugs and beta-blockers. Diuretics are added in the presence of pulmonary congestion. Digoxin is most effective at a blood level of 0.5-0.8 ng/mL because of its pharmacokinetics in DMD. Surgical treatment may be necessary in cases of intractable HF. Cardiac resynchronization therapy (biventricular pacing), a treatment with an artificial pacemaker, is indicated for cases that meet specific criteria, including HF with ventricular dyssynchrony. Applications of partial left ventriculectomy (Batista procedure) and left ventricular assist devices in muscular dystrophy are likely in the near future. (author)

  17. Entrenamiento y adaptación muscular: sustratos y vías metabólicas para la producción de energía

    Directory of Open Access Journals (Sweden)

    Federico Martín Boffi

    2008-07-01

    Full Text Available Tres isoformas de MyHC han sido caracterizadas en músculo esquelético de equinos adultos a nivel proteico: tipo I, IIA y IIX. La distribución de estas MyHCs definen tres tipos puros de fibras que contienen una sola isoforma (tipo I, IIA y IIX y dos tipos de fibras híbridas que expresan dos isoformas (I+IIA y IIAX. Las fibras híbridas IIAX existen en los músculos locomotores como una población estable y significativa. Dependiendo de la naturaleza del estímulo, la respuesta adaptativa puede tomar diferentes formas: hipertrofia, remodelación sin hipertrofia y respuesta mixta, cuando se combina la remodelación con la hipertrofia. Los equinos pueden aprovechar diferentes sustratos energéticos, algunos de los cuales son utilizados en forma inmediata tras la ingesta, mientras que otros son almacenados en el hígado, músculos y tejido adiposo para ser usados en otro momento. El glucógeno muscular y la glucosa pueden ser degradados por la vía aeróbica (oxidativa o la anaeróbica lactacida (glucolítica, mientras que en ejercicios de resistencia la utilización de ácidos grasos se realiza a partir de la degradación de triglicéridos almacenados en el tejido celular subcutáneo. El metabolismo oxidativo mide la función de los sistemas cardiovascular y respiratorio. En cambio, el metabolismo anaeróbico solo involucra al tejido muscular.Three isoforms of MyHc have been characterized in the skeletal muscle of adult equines at the proteins level: types I, IIA and IIX. The distribution of these MyHCs defines three pure kinds of fibre which contain a single isoform (I+IIA and IIAX. The hybrid fibres IIAX exist in the locomotive muscles as a permanent and significant population. The adjusting response may take different forms depending on the nature of the stimulus: hypertrophy, reorganization (restructuring without hypertrophy and a combined answer, when restructuring joins hypertrophy. The equines may take the most of different energetic

  18. Feixes de fibras Lignocelulósicas refinadas mecanicamente em compósitos cimentícios para avaliação da resistência à tração

    Directory of Open Access Journals (Sweden)

    Flávio Airton knuth

    2017-07-01

    Full Text Available As fibras vegetais têm características particulares em relação a outros tipos de fibras usadas em compósitos. Os estudos utilizam, em sua maioria, fibras cuja lignina fora previamente removida pelo processo de polpação. Segundo a literatura, a lignina prejudica a ancoragem fibra-matriz. No entanto, sem a lignina, é necessário que seja feito tratamento superficial no conjunto fibroso. Isso por que as fibras sofrem processo de inchamento e retração no interior da matriz devido a seu caráter hidrofílico, o que diminui sua vida útil. No entanto, a despeito das considerações literárias, esse trabalho se propõe a fazer uso da vantagem de proteção, estruturação e impermeabilização que a lignina exerce sobre as fibras vegetais. Isso implica na necessidade de suprir a redução da resistência do compósito, especialmente à tração, que a lignina causa pela sua atuação negativa na ancoragem fibra-matriz. Para tanto, fibras lignocelulósicas extraídas de talos de banana foram submetidas a processo de refinamento mecânico. Segundo a literatura, a fibra sofre modificações na sua parede externa quando submetida a esse refinamento. Ao final do processo, foram obtidas fibras com formato helicoidal e superfície corrugada o que resultou em maior aderência no conjunto fibra-matriz. As fibras submetidas ao maior grau de refinamento aumentaram a resistência do compósito à tração na compressão diametral em 40% em relação a corpo de prova de cimento puro.

  19. Parental attitudes toward newborn screening for Duchenne/Becker muscular dystrophy and spinal muscular atrophy.

    Science.gov (United States)

    Wood, Molly F; Hughes, Sarah C; Hache, Lauren P; Naylor, Edwin W; Abdel-Hamid, Hoda Z; Barmada, M Michael; Dobrowolski, Steven F; Stickler, David E; Clemens, Paula R

    2014-06-01

    Disease inclusion in the newborn screening (NBS) panel should consider the opinions of those most affected by the outcome of screening. We assessed the level and factors that affect parent attitudes regarding NBS panel inclusion of Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), and spinal muscular atrophy (SMA). The attitudes toward NBS for DMD, BMD, and SMA were surveyed and compared for 2 categories of parents, those with children affected with DMD, BMD, or SMA and expectant parents unselected for known family medical history. The level of support for NBS for DMD, BMD, and SMA was 95.9% among parents of children with DMD, BMD, or SMA and 92.6% among expectant parents. There was strong support for NBS for DMD, BMD, and SMA in both groups of parents. Given advances in diagnostics and promising therapeutic approaches, discussion of inclusion in NBS should continue. Copyright © 2013 Wiley Periodicals, Inc.

  20. Contribuição para o diagóstico diferencial da distrofia muscular progressiva

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    José Antonio Levy

    1964-06-01

    Full Text Available Os dados fornecidos pela anamnese assim como a sintomatologia nem sempre permitem estabelecer, com segurança, o diagnóstico de distrofia muscular progressiva (DMP; o diagnótico é facilitado quando são obtidos dados heredológicos depondo por afecção de caráter familiar ou quando se trate de casos de longa evolução, mostrando a característica fundamental da irreversibilidade. As provas laboratoriais propostas até agora, embora úteis para a avaliação do estado da consunção do tecido muscular, não fornecem elementos seguros para o diagnóstico diferencial, pois os resultados podem ser idênticos tanto na DMP (especialmente nas fases, iniciais ou de evolução subaguda como nas polimiosites e nas neuromiosites. De grande importância para o diagnóstico diferencial são a eletromio-grafia e a biopsia muscular: a eletromiografia mostra, na DMP, diminuição da voltagem e redução da duração média dos potenciais de ação, com elevada incidência de potenciais polifásicos; o exame histológico mostra grande variação no calibre e degeneração das fibras musculares com proliferação de tecido conjuntivo, sem infiltrações de caráter inflamatório e sem atividade regenerativa útil. Entretanto, êstes exames complementares não bastam, por si sós, para o diagnóstico diferencial de todos os casos e seus resultados devem ser interpretados cuidadosamente. Neste trabalho são referidos 21 casos que exigiram cuidadoso diagnóstico diferencial. Em 17 (casos 1 a 17, com base na anamnese e na sintomatologia, fôra feito o diagnóstico de DMP; entretanto em todos êles o exame mais minucioso, acrescido de dados fornecidos pela eletromiografia e especialmente pela biopsia, conduziu à formulação de outro diagnóstico. Em dois casos (18 e 19, ambos de moléstia de Charcot-Marie-Tooth, o exame histo-patológico sugeria o diagnóstico de DMP. Em um caso (20 o quadro clínico sugeria DMP e o exame eletromiográfico indicava haver les

  1. Prevalence of muscular dystrophy in patients with muscular disorders in Tehran, Iran

    Directory of Open Access Journals (Sweden)

    Khadijeh Hajinaghi Tehrani

    2018-05-01

    Full Text Available Muscular dystrophy is a group of diseases that is characterized by progressive muscle wasting and the weakness of variable distribution and severity. On the basis of the distribution of predominant muscle weakness, there are many different kinds of muscular dystrophy. Some dystrophies are especially frequent in certain populations. There are no studies on the prevalence of muscular dystrophy in Iran. This study was aimed to survey the prevalence of muscular dystrophy among Iranian patients with muscular disorders. This analytical cross-sectional study was conducted on 1000 patients with musculoskeletal disorders who visited the dystrophy association of Bou-Ali Hospital (Tehran from June 2014 to June 2016. Patients’ data were extracted using a checklist that included age, gender, age of onset, family history, findings from clinical diagnostic tests and types of muscular dystrophy. The clinical findings were the results of genetic tests; EMG-NCV; para-clinical findings, including LDH and CPK; and pathological findings. All data were analyzed by SPSS V.22 (IBM Inc., NY with Chi Square and One way ANOVA tests. All analyses were performed with P = 0.05 considered as the threshold of statistical significant. Out of the 337 patients studied, 262 (77.7% were male and 75 (22.3% were female. Subjects had a mean (± SD age of 26.08 (± 11.86 years with an age range of 3 to 59 years. The most common types of muscular dystrophy were found to be Duchenne dystrophy (131 cases, 38.9%, limb-girdle dystrophy (91 cases, 27%, Becker dystrophy (58 cases, 17.2%, FSHD dystrophy (31 cases, 9.2%, and SMA (26 cases, 7.7%, respectively. The results showed that a statistically significant relationship between dystrophy types and gender, age, family history, age of diagnosis, CPK and LDH levels (P < 0.001. There were no statistical relationship between dystrophy types and pathological findings (P = 0.57, EMG-NCV test results (P = 0.062, and genetic findings (P = 0

  2. Recent developments in the treatment of Duchenne muscular dystrophy and spinal muscular atrophy

    Science.gov (United States)

    Liew, Wendy K. M.

    2013-01-01

    Pediatric neuromuscular disorders comprise a large variety of disorders that can be classified based on their neuroanatomical localization, patterns of weakness, and laboratory test results. Over the last decade, the field of translational research has been active with many ongoing clinical trials. This is particularly so in two common pediatric neuromuscular disorders: Duchenne muscular dystrophy and spinal muscular atrophy. Although no definitive therapy has yet been found, numerous active areas of research raise the potential for novel therapies in these two disorders, offering hope for improved quality of life and life expectancy for affected individuals. PMID:23634188

  3. Estimulação elétrica neuromuscular em cães com atrofia muscular induzida Neuromuscular electric stimulation in dogs with induced muscle atrophy

    Directory of Open Access Journals (Sweden)

    C. Pelizzari

    2008-02-01

    Full Text Available Empregou-se a estimulação elétrica neuromuscular (EENM de baixa freqüência no músculo quadríceps femoral de cães com atrofia induzida e avaliou-se a ocorrência de ganho de massa nessa musculatura. Foram utilizados oito cães com pesos entre 15 e 30kg, distribuídos aleatoriamente em dois grupos denominados de I ou controle e II ou tratado. A articulação femorotibiopatelar esquerda foi imobilizada por 30 dias pelo método de transfixação percutânea tipo II, com retirada de aparelho de imobilização após esse período. Decorridas 48 horas da remoção, foi realizada a EENM nos cães do grupo II, cinco vezes por semana, com intervalo de 24 horas cada sessão, pelo período de 60 dias. Foram avaliadas a circunferência da coxa, a goniometria do joelho, a análise clínica da marcha, as enzimas creatina-quinase (CK e aspartato-amino-transferase (AST e a morfometria das fibras musculares em cortes transversais do músculo vasto lateral colhido mediante biópsia muscular. A EENM foi empregada no músculo quadríceps femoral na freqüência de 50Hz, duração de pulso de 300 milisegundos e relação de tempo on/off de 1:2. Quanto à morfometria das fibras do músculo vasto lateral, no grupo tratado houve aumento significativo (PLow frequency neuromuscular electrical stimulation (NMES was used on the femoral quadriceps of dogs with induced muscular atrophy and the occurrence of gain in mass in these muscles was evaluated. Eight dogs from 15 to 30kg were randomly distributed in two groups named I, or control; and II, or treated. For the induction of muscular atrophy, the left femoral-tibial-patellar joint was immobilized for 30 days by percutaneous transfixation type II. After 30 days, the immobilization device was removed. The NMES treatment began 48 hours after the removal of the immobilization device of the dogs of group II, and it was carried out five times per week with an interval of 24 hours between each session, for 60 days. The

  4. Aplicações de fibras vegetais na secagem de concretos refratários Use of natural fibers to speed up the drying step of refractory castables

    Directory of Open Access Journals (Sweden)

    C. S. Isaac

    2004-06-01

    Full Text Available A secagem de concretos refratários é uma etapa crítica em seu processamento devido aos riscos de explosão durante a saída de água contida em sua estrutura. Para minimizar esses problemas e aumentar a velocidade de secagem, fibras poliméricas têm sido adicionadas às formulações de concreto. Uma variável importante a ser considerada no desempenho desse aditivo é o tipo de fibra utilizada. Trabalhos do grupo de pesquisa indicaram que fibras vegetais podem apresentar bom desempenho na geração de canais permeáveis. Esse fato, aliado à sua grande disponibilidade e baixo custo, sugere que estas fibras sejam uma alternativa interessante às fibras sintéticas utilizadas atualmente. Neste trabalho, comparou-se o desempenho de fibras vegetais com o do polipropileno utilizados como aditivos de secagem. Foram realizadas medidas de permeabilidade utilizando a Equação de Forchheimer, ensaios de permeametria em alta temperatura e análise termogravimétrica do concreto. As fibras foram caracterizadas por calorimetria exploratória diferencial e termogravimetria.The drying of refractory castables is a critical step during application due to the possibility of spalling. In order to decrease these risks and improve the drying rate, polymeric fibers have been added to the castables' formulation. The type of fiber is an important aspect to be studied. Authors' previous works indicated that vegetable fibers can be good candidates. This fact, associated with its wide availability and low cost, suggests that these fibers can be interesting substitutes to synthetic ones. In this work, vegetable and polypropylene fibers had their performance evaluated as drying agents. The results of permeability measurements and hot air permeametry were related with the thermogravimety of the fiber-containing castables. The fibers were characterized by differential scanning calorimetry and thermogravimetry.

  5. Cognitive and Neurobehavioral Profile in Boys With Duchenne Muscular Dystrophy.

    Science.gov (United States)

    Banihani, Rudaina; Smile, Sharon; Yoon, Grace; Dupuis, Annie; Mosleh, Maureen; Snider, Andrea; McAdam, Laura

    2015-10-01

    Duchenne muscular dystrophy is a progressive neuromuscular condition that has a high rate of cognitive and learning disabilities as well as neurobehavioral disorders, some of which have been associated with disruption of dystrophin isoforms. Retrospective cohort of 59 boys investigated the cognitive and neurobehavioral profile of boys with Duchenne muscular dystrophy. Full-scale IQ of Duchenne muscular dystrophy. © The Author(s) 2015.

  6. Infiltração de sal de alumínio em fibras de sisal para obtenção de fibras de alumina Infiltration of aluminum salt into sisal to produce alumina fibers

    Directory of Open Access Journals (Sweden)

    T. E. Andrade Jr.

    2005-03-01

    Full Text Available O sisal é um recurso estratégico para a região Nordeste e, particularmente, para o estado do Rio Grande do Norte, por ser uma cultura renovável e adaptada às condições do semi-árido. Em virtude das condições adversas de clima e solo, o sisal é, em algumas regiões, o único produto agrícola rentável passível de plantio. Agregar valor aos produtos manufaturados a partir do sisal contribui não só para o desenvolvimento científico e tecnológico da região, como também para a geração de renda para a população dos municípios potiguares produtores de sisal. Da planta extraem-se fibras ligninocelulósicas utilizadas na produção artesanal de cordas e industrial de mantas e tapetes. Uma outra alternativa é o aproveitamento da estrutura da fibra para a produção de fibras de alumina (Al2O3 pela biomodelagem. Este processo consiste na reprodução da estruturas natural do material de partida. O objetivo deste trabalho foi estudar as condições de infiltração da fibra de sisal com sal de alumínio para posterior conversão da estrutura em fibras de alumina. Inicialmente, as fibras de sisal foram pré-tratadas com hidróxido de sódio, infiltradas com uma solução saturada de sal de alumínio (Al2Cl6 e sinterizadas entre 1400 °C e 1650 °C. A caracterização das fibras de alumina foi feita por difração de raios X e microscopia eletrônica de varredura. Os resultados mostraram a conversão completa apenas da superfície da fibra de sisal em alfa-Al2O3, resultando em baixa resistência ao manuseio. Novos métodos de infiltração são propostos com o objetivo de reproduzir-se a estrutura interna da fibra de sisal, resultando em fibras materiais com melhor resistência mecânica.Sisal is a renewable agricultural resource adapted to the hostile climatic and soil conditions particularly encountered in the semi-arid areas of the state of Rio Grande do Norte, located in Northeastern Brazil. Consequently, sisal has played a

  7. Influência do exercício físico sobre a via da miostatina e o fenótipo muscular em ratos submetidos a alimentação intermitente

    OpenAIRE

    Oliveira, Ana Priscila Cayres de

    2016-01-01

    A alimentação intermitente (AI), alternativa à tradicional restrição calórica (RC), consiste em intervenção dietética envolvendo ciclos de jejum e alimentação. O principal efeito da RC tradicional sobre a musculatura esquelética é a redução do tamanho da fibra, a qual pode ser atenuada pelo exercício físico. Entretanto, pouco se sabe sobre a influência da AI sobre o fenótipo muscular e os mecanismos moleculares envolvidos. Neste sentido, a miostatina é um fator de crescimento que regula negat...

  8. Muscular anatomy of the Podocoryna carnea hydrorhiza.

    Science.gov (United States)

    Buss, Leo W; Anderson, Christopher; Bolton, Edward W

    2013-01-01

    The muscular anatomy of the athecate hydroid Podocoryna carnea hydrorhiza is elucidated. The polyp-stolon junction is characterized by an opening, here called the chloe, in the otherwise continuous hydrorhizal perisarc. The chloe is elliptical when the polyp first arises, but takes on a more complex outline as multiple stolons anastomose to communicate with that polyp. Surrounding the polyp base are spots, here called anchors, which autofluoresce at the same wavelengths as perisarc and which, like perisarc, contain chitin as assessed by Calcofluor White, Congo Red and wheat germ agglutinin staining. Anchors remain after living tissues are digested using KOH. Collagen IV staining indicates that the mesoglea is pegged to the anchors and rhodamine phallodin staining detects cytoskeletal F-actin fibers of the basal epidermis surrounding the anchors. Longitudinal muscle fibers of the polyp broaden at the polyp base and are inserted into the mesoglea of the underlying stolon, but were neither observed to extend along the stolonal axis nor to attach to the anchors. Circular muscular fibers of the polyp extend into stolons as a dense collection of strands running along the proximal-distal axis of the stolon. These gastrodermal axial muscular fibers extend to the stolon tip. Epidermal cells at the stolon tip and the polyp bud display a regular apical latticework of F-actin staining. A similar meshwork of F-actin staining was found in the extreme basal epidermis of all stolons. Immunohistochemical staining for tubulin revealed nerves at stolon tips, but at no other hydrorhizal locations. These studies bear on the mechanisms by which the stolon tip and polyp bud pulsate, the manner in which the stolon lumen closes, and on the developmental origin of the basal epidermis of the hydrorhiza.

  9. Nose muscular dynamics: the tip trigonum.

    Science.gov (United States)

    Figallo, E E; Acosta, J A

    2001-10-01

    In 1995, the senior author (E.E.F.) published an article in which he described the musculus digastricus septi nasi labialis. In the article presented here, work carried out by anatomists and other researchers who, over the last two centuries, studied nose muscular dynamics is described. The present study is based on Gray's Anatomy, which, in 1858, first described the nasal tip muscles, along with the other nasal muscles. Later works not only used different terminology for these muscles but also ignored some, creating tremendous confusion. The study presented here provides an update of the exact terms, location, insertions, and muscle functions of the muscles of the nose. Each nose muscle is described with regard to the two portions able to produce separate contractions. In this study, the term "dual function" is used and characterizes the nasal mimetic muscles that do not have well-defined fascia. Therefore, there is doubt about the existence of a real nasal superficial muscle aponeurotic system. The musculus myrtiformis seems to have a dual function, inserting in the canine fosse and in the periosteum of the central incisors, forming two portions-one to the septum and the other to the nostril-each of which has specific functions. This study has been based on research in physiognomy, the science of expression. With regard to the basis for nose expressions, common anatomical research is excluded because it provides a different view of the dynamics studied to date. The term trigonum musculare apicis nasi defines the interaction of the musculi compressor narium minor and dilator naris anterior, connecting with the columellar bundle of the musculus digastricus and levering the nasal spine. This muscular trigone creates circular concentric and eccentric movements of the nasal tip.

  10. A comparison of swallowing dysfunction in Becker muscular dystrophy and Duchenne muscular dystrophy.

    Science.gov (United States)

    Yamada, Yuka; Kawakami, Michiyuki; Wada, Ayako; Otsuka, Tomoyoshi; Muraoka, Kaori; Liu, Meigen

    2018-06-01

    Swallowing dysfunction has been reported in Duchenne muscular dystrophy (DMD), but has not been studied in Becker muscular dystrophy (BMD). The aims of this study were to report the characteristics of swallowing dysfunction in BMD compared with DMD. The study participants were 18 patients with BMD and 18 patients with DMD. All the patients were examined using videofluorography during swallowing of 5 mL of fluid. The penetration-aspiration scale (P-A scale) and the videofluorographic dysphagia scale (VDS) were used to evaluate dysphagia. Swinyard functional ability stage was not significantly different between the BMD and DMD groups. Rate of aspiration, P-A scale score, and total VDS score did not differ across groups, but the VDS item score for laryngeal elevation was lower in the BMD group than in the DMD group (median scores 4.5 and 9, respectively; p Becker muscular dystrophy (BMD) was not well known. Eighteen patients with BMD and 18 patients with Duchenne muscular dystrophy were examined with videofluorography. Patients with BMD have swallowing problems similar to those observed in patients with DMD.

  11. Força e arquitetura muscular do gémeo interno na bomba muscular venosa

    OpenAIRE

    Peixoto, Flávia; Pinto, Ângela; Kozlova, Veronika; Crisóstomo, Rute

    2015-01-01

    Objetivo: Avaliar e comparar a Força Muscular (FM), Amplitude de Movimento (ADM) e Arquitetura Muscular da bomba muscular venosa em sujeitos com e sem Insuficiência Venosa Crónica (IVC). Relevância: A IVC provoca alterações na função da bomba muscular venosa, no entanto, pouco se conhece acerca das suas repercussões físicas e funcionais. Amostra: Sujeitos com IVC (alterações da tróficas, e úlcera ativa/cicatrizada) e saudáveis. Foram avaliados 33 sujeitos dos quais foram analis...

  12. [Complete atrioventricular block in Duchenne muscular dystrophy].

    Science.gov (United States)

    Kuru, Satoshi; Tanahashi, Tamotsu; Matsumoto, Shinjirou; Kitamura, Tetsuya; Konagaya, Masaaki

    2012-01-01

    We report a case of complete atrioventricular (AV) block in a 40-year-old patient with Duchenne muscular dystrophy (DMD). While he was bed-ridden and required mechanical ventilation, his cardiac involvement was mild. He had the deletion of exon 45-52 in the dystrophin gene. He underwent transient complete AV block and came to require pacemaker implantation due to recurrence of complete AV block ten days after the first attack. Electrophysiological study revealed mild prolonged AH and HV interval. Although DMD patients with AV block have been rarely reported so far, attention should be paid to AV block for patients who prolonged their lives.

  13. Spinal muscular atrophy present in children

    OpenAIRE

    Garófalo Gómez, Nicolás; Zaldívar Vaillant, Tatiana; Vargas Díaz, José; Rojas Massipe, Edelsia; Novoa López, Lucía

    2009-01-01

    INTRODUCCIÓN. Las atrofias musculares espinales en la infancia (AME) son trastornos genéticos autosómicos recesivos, caracterizados por degeneración de las motoneuronas espinales y bulbares. El presente estudio tuvo el objetivo principal de describir las principales características clínicas en una serie de niños con AME. MÉTODOS. Se realizó un estudio retrospectivo de los pacientes con AME atendidos en el Instituto de Neurología y Neurocirugía de Cuba, entre enero de 1997 y diciembre de 2001....

  14. Merosin/laminin-2 and muscular dystrophy

    DEFF Research Database (Denmark)

    Wewer, U M; Engvall, E

    1996-01-01

    structural organization of domains, some of which have been assigned biological activities, including self-assembly and interactions with other proteins. The particular importance of laminins for the formation and stability of cell adhesion complexes is highlighted in severe inherited diseases of muscle...... and skin. Merosin is the collective name for laminins that share a common subunit, the laminin alpha 2 chain. Merosin-deficient congenital muscular dystrophy (CMD) is caused by mutations in the laminin alpha 2 chain gene. The skin disease Herlitz junctional epidermolysis bullosa is caused by mutations...

  15. Muscular cysticercosis: Case report and imaging findings

    Directory of Open Access Journals (Sweden)

    Neide Regina Simões Olmo

    Full Text Available Summary Cysticercosis is a parasitic disease caused by a worm of the Cestoda class. The most prevalent form affects the nervous system. This case report is from a 78-year-old female patient evaluated at Clínica Mult Imagem, in the city of Santos, Brazil, who presented a form of the disease that differed from the classic neurocysticercosis, in this case muscular cysticercosis. This and other forms of manifestation justify further studies to ensure adequate recognition, diagnosis and treatment of this parasitic disease.

  16. PROPIEDADES TÉCNICO-FUNCIONALES DE LA FIBRA DIETARIA DE CÁSCARAS DE MANGO VARIEDADHILACHA (Mangifera indica L.: EFECTO DEL SECADO POR CONVECCIÓN

    Directory of Open Access Journals (Sweden)

    GUSTAVO ADOLFO HINCAPIÉ LL.

    2014-06-01

    Full Text Available Un subproducto de la obtención del jugo de mango es su cáscara; la cual contiene niveles considerables de fibra dietaria que podrían ser utilizados en la elaboración de productos alimenticios, sin embargo, actualmente no es muy aprovechado. El proceso de secado prolonga la vida útil de la cascara y permite que pueda ser adicionada a otros alimentos. En este estudio, se caracterizó fisicoquímicamente la Cáscara de Mango Hilacha (CMH y se evaluó el efecto de cinco temperaturas de secado sobre las propiedades técnico-funcionales de la fibra dietaria; Capacidad de Hinchamiento (CH, Capacidad de Retención de Agua (CRA y Capacidad de Adsorción de Lípidos (CAL, características que determinan en gran medida la calidad de la fibra dietaria (FD. Los resultados obtenidos indican que la CMH tiene un contenido de fibra dietaria total, proteína, extracto etéreo, carbohidratos y fibra cruda similar al de otras variedades de mango. La cáscara de mango hilacha seca y molida (CSMH obtenida, es una promisoria fuente de FD, ya que su calidad no se vio afectada significativamente por el proceso de secado empleado en este trabajo.

  17. Optical metrology alignment and impact on the measurement performance of the LISA Technology Package

    Energy Technology Data Exchange (ETDEWEB)

    Hirth, M; Fichter, W; Brandt, N; Gerardi, D [iFR, Universitaet Stuttgart, Pfaffenwaldring 7a, 70569 Stuttgart (Germany); Schleicher, A [Astrium GmbH, 88039 Friedrichshafen (Germany); Wanner, G, E-mail: marc.hirth@ifr.uni-stuttgart.d [Albert Einstein Institut, Callinstrasse 38, 30167 Hannover (Germany)

    2009-03-01

    Aside from LISA Pathfinder's top-level acceleration requirement, there is a stringent independent requirement for the accuracy of the optical metrology system. In case of a perfectly aligned metrology system (optical bench and test masses) it should rather be independent of residual displacement jitter due to control. However, this ideal case will not be achieved as mechanical tolerances and uncertainties lead to a direct impact of test mass and spacecraft displacement jitter on the optical measurement accuracy. In this paper, we present a strategy how to cover these effects for a systematic requirement breakdown. We use a simplified nonlinear geometrical model for the differential distance measurement of the test masses which is linearized and linked to the equations of motion for both the spacecraft and the two test masses. This leads from test mass relative displacement to a formulation in terms of applied force/torque and thus allows to distinguish the absolute motion of each of the three bodies. It further shows how motions in each degree of freedom couple linearly into the optical measurement via DC misalignments of the laser beam and the test masses. This finally allows for deriving requirements on the alignment accuracy of components and on permittable closed-loop acceleration noise. In the last part a budget for the expected measurement performance is compiled from simulations as no measurement data is available yet.

  18. The late inspiral of supermassive black hole binaries with circumbinary gas discs in the LISA band

    Science.gov (United States)

    Tang, Yike; Haiman, Zoltán; MacFadyen, Andrew

    2018-05-01

    We present the results of 2D, moving-mesh, viscous hydrodynamical simulations of an accretion disc around a merging supermassive black hole binary (SMBHB). The simulation is pseudo-Newtonian, with the BHs modelled as point masses with a Paczynski-Wiita potential, and includes viscous heating, shock heating, and radiative cooling. We follow the gravitational inspiral of an equal-mass binary with a component mass Mbh = 106 M⊙ from an initial separation of 60rg (where rg ≡ GMbh/c2 is the gravitational radius) to the merger. We find that a central, low-density cavity forms around the binary, as in previous work, but that the BHs capture gas from the circumbinary disc and accrete efficiently via their own minidiscs, well after their inspiral outpaces the viscous evolution of the disc. The system remains luminous, displaying strong periodicity at twice the binary orbital frequency throughout the entire inspiral process, all the way to the merger. In the soft X-ray band, the thermal emission is dominated by the inner edge of the circumbinary disc with especially clear periodicity in the early inspiral. By comparison, harder X-ray emission is dominated by the minidiscs, and the light curve is initially more noisy but develops a clear periodicity in the late inspiral stage. This variability pattern should help identify the electromagnetic counterparts of SMBHBs detected by the space-based gravitational-wave detector LISA.

  19. Optical metrology alignment and impact on the measurement performance of the LISA Technology Package

    International Nuclear Information System (INIS)

    Hirth, M; Fichter, W; Brandt, N; Gerardi, D; Schleicher, A; Wanner, G

    2009-01-01

    Aside from LISA Pathfinder's top-level acceleration requirement, there is a stringent independent requirement for the accuracy of the optical metrology system. In case of a perfectly aligned metrology system (optical bench and test masses) it should rather be independent of residual displacement jitter due to control. However, this ideal case will not be achieved as mechanical tolerances and uncertainties lead to a direct impact of test mass and spacecraft displacement jitter on the optical measurement accuracy. In this paper, we present a strategy how to cover these effects for a systematic requirement breakdown. We use a simplified nonlinear geometrical model for the differential distance measurement of the test masses which is linearized and linked to the equations of motion for both the spacecraft and the two test masses. This leads from test mass relative displacement to a formulation in terms of applied force/torque and thus allows to distinguish the absolute motion of each of the three bodies. It further shows how motions in each degree of freedom couple linearly into the optical measurement via DC misalignments of the laser beam and the test masses. This finally allows for deriving requirements on the alignment accuracy of components and on permittable closed-loop acceleration noise. In the last part a budget for the expected measurement performance is compiled from simulations as no measurement data is available yet.

  20. Picometer stable scan mechanism for gravitational wave detection in space: LISA PAAM

    Science.gov (United States)

    Pijnenburg, J. A. C. M.; Rijnveld, N.

    2017-11-01

    Detection and observation of gravitational waves requires extreme stability in the frequency range 0.03 mHz to 1 Hz. The Laser Interferometer Space Antenna (LISA) mission will attain this by creating a giant interferometer in space, based on free floating proof masses in three spacecrafts. Due to orbit evolution and time delay in the interferometer arms, the direction of transmitted light changes. To solve this problem, a picometer stable Point-Ahead Angle Mechanism (PAAM) was designed, realized and successfully tested. The PAAM concept is based on a rotatable mirror. The critical requirements are the contribution to the optical path length (less than 1.4 pm / rt Hz) and the angular jitter (less than 8 nrad / rt Hz). Extreme dimensional stability is achieved by manufacturing a monolithical Haberland hinge mechanism out of Ti6Al4V, through high precision wire erosion. Extreme thermal stability is realized by placing the thermal center on the surface of the mirror. Because of piezo actuator noise and leakage, the PAAM has to be controlled in closed-loop. To meet the requirements in the low frequencies, an active target capacitance-to-digital converter is used. Interferometric measurements with a triangular resonant cavity in vacuum proved that the PAAM meets the requirements.

  1. Testing and Characterization of a Prototype Telescope for the Evolved Laser Interferometer Space Antenna (eLISA)

    Science.gov (United States)

    Sankar, S.; Livas, J.

    2016-01-01

    We describe our efforts to fabricate, test and characterize a prototype telescope for the eLISA mission. Much of our work has centered on the modeling and measurement of scattered light performance. This work also builds on a previous demonstration of a high dimensional stability metering structure using particular choices of materials and interfaces. We will discuss ongoing plans to merge these two separate demonstrations into a single telescope design demonstrating both stray light and dimensional stability requirements simultaneously.

  2. Relaci??n entre la masa muscular, la densidad mineral ??sea, la fuerza muscular, la aptitud funcional y la calidad muscular en personas mayores

    OpenAIRE

    Pati??o Villada, Fredy Alonso

    2015-01-01

    294 p. La tesis pretende determinar la frecuencia de la sarcopenia y osteporosis , problemas que afectan a la salud de las personas mayores, y analizar la relaci??n entre la masa muscular, la densidad mineral ??sea (DMO), la fuerza muscular, la aptitud funcional y la calidad muscular (CM). La muestra estudiada fue la formada por un grupo de 83 hombres y 175 mujeres mayores de Le??n (Espa??a). El estudio transversal eval??a ??ndices de masa grasa y densidad mineral ??sea y niveles d...

  3. Prevalence of obesity, sarcopenic obesity and associated factors: A FIBRA Network study

    Directory of Open Access Journals (Sweden)

    Carla Moura Santos

    Full Text Available Abstract Introduction: Sarcopenic obesity in older adults may lead to an inability to use muscles efficiently and has been associated with functional deficits and disabilities. Objective: To identify the prevalence of obesity and sarcopenic obesity (SO among community-dwelling older adults, and to characterize associated sociodemographics, health conditions and functional performance. Methods: Study data are from the FIBRA Network database of the Federal University of Minas Gerais. There were 1,373 older adult participants, subdivided into three groups: 1 non-obese; 2 non-sarcopenic obese; and 3 sarcopenic obese (SO. The latter is defined as a BMI ≥30 kg/m2 and weak palmar grip strength (PGS. Results: The overall prevalence of obesity and SO among older adults was 25.85% and 4.44%, respectively, with levels of frailty and pre-frailty among at 36.1% and 59%, respectively. Gait speed (GS was lower in the SO group as well, compared to the other groups. An average increase in GS of 0.1 m/sec reduced the likelihood of SO by 85.1%, in average. Sarcopenic obese older adults were 14.2 times more likely to be pre-fragile and 112.9 times more likely to be fragile than the other groups. Conclusion: The prevalence of obesity found in this study was higher than that in the general population, but similar to national statistics for the sample’s mean age and gender. SO was directly associated with frailty in advanced and instrumental activities of daily living as well as gait speed and significantly increased the likelihood of being pre-frail and frail. GS may be an extremely useful tool for monitoring the progress of SO in older adults.

  4. Postes prefabricados de fibra: Consideraciones para su uso clínico

    Directory of Open Access Journals (Sweden)

    Hugo Calabria Díaz

    Full Text Available En la década de los 90 los Postes Prefabricados de Fibra (PPF se introdujeron al mercado como alternativa a los sistemas metálicos o cerámicos. Hasta la fecha se mantienen en uso, modificando de manera constante sus presentaciones comerciales y estrategias de fijación. Sus cualidades mecánicas como su bajo Módulo Elástico (ME similar al dentinario, introducen un nuevo paradigma en la rehabilitación del Diente Endodonticamente Tratado (DET: .ldquo;el poste debe acompañar en forma solidaria la flexión de los tejidos dentarios frente a las cargas.rdquo;. Sus actuales cualidades estéticas, la fácil remoción y la posibilidad de su cementado adhesivo, los han convertido en una alternativa válida a las soluciones convencionales. Sin embargo, algunos resultados contradictorios junto con la importante dificultad de lograr hibridación en la dentina radicular, mantienen interrogantes a resolver en el futuro. Se indican en casos en donde se prevea retratamiento, en pacientes jóvenes, de alta exigencia estética y toda vez que se quiera y pueda eludir los costos de aleaciones nobles. En el presente artículo se analizan los fundamentos clínicos y experimentales de distintos autores, extrapolándose consideraciones prácticas para su uso. Los mismos se ilustran en un caso clínico para un paciente joven, con antecedente de traumatismo y con altas expectativas estéticas

  5. Espalhamento e secagem de filme de amido-glicerol-fibra preparado por "tape-casting"

    Directory of Open Access Journals (Sweden)

    Jaqueline Oliveira de Moraes

    2014-02-01

    Full Text Available O objetivo deste trabalho foi avaliar processos de espalhamento e secagem de filme de amido-glicerol-fibras de celulose, preparado por "tape-casting". O espalhamento da suspensão foi avaliado a 50, 150 e 250 cm min-1, seguido de secagem em estufa com circulação forçada de ar, a 40 ou 70ºC; avaliou-se também o espalhamento da suspensão a 150 cm min-1, seguido da secagem do filme sobre suporte de "tape-casting" a 22ºC e 60% de umidade relativa, com velocidades do ar de 4, 6 e 8 m s-1 no túnel de secagem. Ensaios reológicos mostraram que o espalhamento das suspensões a temperaturas inferiores a 50ºC apresentou módulo de elasticidade superior ao módulo viscoso, em todo o espectro de frequências de oscilação. As microscopias mostraram filmes secos a 40 e 70ºC sem defeitos de formação, e cujas propriedades mecânicas não diferiam. A velocidade de espalhamento e a do ar não modificam o tempo de secagem nem as propriedades dos filmes. O tempo de secagem pode ser reduzido para aproximadamente duas horas, o que é importante para a produção dos filmes em larga escala.

  6. The End of Panopticon/panopticism in William Gibson’s Mona Lisa Overdrive : A Baudrillardian Reading

    Directory of Open Access Journals (Sweden)

    Hanieh Zaltash

    2014-11-01

    Full Text Available This paper seeks to examine William Gibson’s Mona Lisa Overdrive as a cyberpunk novel in the light of Baudrillard’s theory of “Simulation”. Jean Baudrillard believes that reality is replaced by “hyperreality” and human beings live in a total “simulation” in which everything, such as power might be simulated. Thus, according to Baudrillard, power exists just as “the simulation of power” which is the result of “the circularization of power” between the dominator and the dominated. Baudrillard delineates “the circularization of power” through criticizing Michel Foucault’s theories regarding power and panopticon, and introduces “the end of panopticon” which is centered upon the reversibility of the positions of the observer and the observed. In a meticulous analysis of TV performance of the Loud family in 1971, Baudrillard claims that the panoptic system is ended through playing on the opposition of seeing and being seen. The findings suggest that Mona Lisa Overdrive depicts “the end of panopticon,” in a sense that Angie Mitchell in this novel can be considered as a counterpart for Baudrillard’s instance of the Loud family. Indeed, this study attempts to elucidate “the end of panopticon” in Mona Lisa Overdrive (1988 through scrutinizing Angie Mitchell’s way of living.

  7. Muscular subunits transplantation for facial reanimation

    Directory of Open Access Journals (Sweden)

    Hazan André Salo Buslik

    2006-01-01

    Full Text Available PURPOSE: To present an alternative technique for reconstruction of musculocutaneous damages in the face transferring innervated subsegments(subunits of the latissimus dorsi flap for replacement of various facial mimetic muscles. METHODS: One clinical case of trauma with skin and mimetic muscles damage is described as an example of the technique. The treatment was performed with microsurgical transfer of latissimus dorsi muscle subunits. Each subunit present shape and dimensions of the respective mimetic muscles replaced. The origin, insertions and force vectors for the mimicmuscle lost were considered. Each subsegment has its own arterial and venous supply with a motor nerve component for the muscular unit. RESULTS: Pre and one year postoperative photos registration of static and dynamic mimic aspects, as well as digital electromyography digital data of the patients were compared. The transplanted muscular units presented myoeletric activity, fulfilling both the functional and cosmetic aspect. CONCLUSION: This technique seems to be a promising way to deal with the complex musculocutaneous losses of the face as well as facial palsy.

  8. Muscle MRI findings in facioscapulohumeral muscular dystrophy

    Energy Technology Data Exchange (ETDEWEB)

    Gerevini, Simonetta; Caliendo, Giandomenico; Falini, Andrea [IRCCS San Raffaele Scientific Institute, Neuroradiology Unit, Head and Neck Department, Milan (Italy); Scarlato, Marina; Previtali, Stefano Carlo [IRCCS San Raffaele Scientific Institute, Department of Neurology, INSPE and Division of Neuroscience, Milan (Italy); Maggi, Lorenzo; Pasanisi, Barbara; Morandi, Lucia [Fondazione IRCCS Istituto Neurologico ' ' Carlo Besta' ' , Neuromuscular Diseases and Neuroimmunology Unit, Milan (Italy); Cava, Mariangela [IRCCS San Raffaele Scientific Institute, Department of Radiology and Center for Experimental Imaging, Milan (Italy)

    2016-03-15

    Facioscapulohumeral muscular dystrophy (FSHD) is characterized by extremely variable degrees of facial, scapular and lower limb muscle involvement. Clinical and genetic determination can be difficult, as molecular analysis is not always definitive, and other similar muscle disorders may have overlapping clinical manifestations. Whole-body muscle MRI examination for fat infiltration, atrophy and oedema was performed to identify specific patterns of muscle involvement in FSHD patients (30 subjects), and compared to a group of control patients (23) affected by other myopathies (NFSHD). In FSHD patients, we detected a specific pattern of muscle fatty replacement and atrophy, particularly in upper girdle muscles. The most frequently affected muscles, including paucisymptomatic and severely affected FSHD patients, were trapezius, teres major and serratus anterior. Moreover, asymmetric muscle involvement was significantly higher in FSHD as compared to NFSHD patients. In conclusion, muscle MRI is very sensitive for identifying a specific pattern of involvement in FSHD patients and in detecting selective muscle involvement of non-clinically testable muscles. Muscle MRI constitutes a reliable tool for differentiating FSHD from other muscular dystrophies to direct diagnostic molecular analysis, as well as to investigate FSHD natural history and follow-up of the disease. (orig.)

  9. Clinico-epidemiologic characteristics of spinal muscular atrophy ...

    African Journals Online (AJOL)

    Rabah M. Shawky

    Deletion;. Chromosome 5;. Mutations. Abstract Spinal muscular atrophy (SMA) is characterized by progressive hypotonia and muscular weakness because of progressive degeneration of alpha motor neuron from anterior horn cells in the spinal cord. It is inherited by an autosomal recessive pattern. The precise frequency of ...

  10. Morphologic imaging in muscular dystrophies and inflammatory myopathies

    International Nuclear Information System (INIS)

    Degardin, Adrian; Lacour, Arnaud; Vermersch, Patrick; Morillon, David; Cotten, Anne; Stojkovic, Tanya

    2010-01-01

    To determine if magnetic resonance imaging (MR imaging) is useful in the diagnostic workup of muscular dystrophies and idiopathic inflammatory myopathies for describing the topography of muscle involvement. MR imaging was performed in 31 patients: 8 with dystrophic myotony types 1 (n = 4) or 2 (n = 4); 11 with limb-girdle muscular dystrophy, including dysferlinopathy, calpainopathy, sarcoglycanopathy, and dystrophy associated with fukutin-related protein mutation; 3 with Becker muscular dystrophy; and 9 with idiopathic inflammatory myopathies, including polymyositis, dermatomyositis, and sporadic inclusion body myositis. Analysis of T1 images enabled us to describe the most affected muscles and the muscles usually spared for each muscular disease. In particular, examination of pelvis, thigh, and leg muscles demonstrated significant differences between the muscular diseases. On STIR images, hyperintensities were present in 62% of our patients with muscular dystrophies. A specific pattern of muscular involvement was established for each muscular disease. Hyperintensities observed on STIR images precede fatty degeneration and are not specific for inflammatory myopathies. (orig.)

  11. Dysphagia in Duchenne Muscular Dystrophy Assessed by Validated Questionnaire

    Science.gov (United States)

    Archer, Sally K.; Garrod, Rachel; Hart, Nicholas; Miller, Simon

    2013-01-01

    Background: Duchenne muscular dystrophy (DMD) leads to progressive muscular weakness and death, most typically from respiratory complications. Dysphagia is common in DMD; however, the most appropriate swallowing assessments have not been universally agreed and the symptoms of dysphagia remain under-reported. Aims: To investigate symptoms of…

  12. Upper limb function in adults with Duchenne muscular dystrophy

    NARCIS (Netherlands)

    B. Bartels (Bart); R.F. Pangalila (Robert); M.P. Bergen (Michael); N.A.M. Cobben (Nicolle); H.J. Stam (Henk); M.E. Roebroeck (Marij)

    2011-01-01

    textabstractTo determine upper limb function and associated factors in adults with Duchenne muscular dystrophy. Design: Cross-sectional study. Subjects: A sample of 70 men with Duchenne muscular dystrophy (age range 20-43 years). Methods: General motor function and, in particular, upper limb distal

  13. Limb girdle muscular dystrophy due to mutations in POMT2

    DEFF Research Database (Denmark)

    Østergaard, Sofie Thurø; Johnson, Katherine; Stojkovic, Tanya

    2018-01-01

    BACKGROUND: Mutations in the gene coding for protein O-mannosyl-transferase 2 (POMT2) are known to cause severe congenital muscular dystrophy, and recently, mutations in POMT2 have also been linked to a milder limb-girdle muscular dystrophy (LGMD) phenotype, named LGMD type 2N (LGMD2N). Only four...

  14. Morphologic imaging in muscular dystrophies and inflammatory myopathies

    Energy Technology Data Exchange (ETDEWEB)

    Degardin, Adrian; Lacour, Arnaud; Vermersch, Patrick [CHU de Lille, Clinique neurologique, Lille (France); Morillon, David; Cotten, Anne [CHRU de Lille, Service de Radiologie Osteoarticulaire, Hopital Roger Salengro, Lille (France); Stojkovic, Tanya [G-H Pitie-Salpetriere, Institut de Myologie, Paris (France)

    2010-12-15

    To determine if magnetic resonance imaging (MR imaging) is useful in the diagnostic workup of muscular dystrophies and idiopathic inflammatory myopathies for describing the topography of muscle involvement. MR imaging was performed in 31 patients: 8 with dystrophic myotony types 1 (n = 4) or 2 (n = 4); 11 with limb-girdle muscular dystrophy, including dysferlinopathy, calpainopathy, sarcoglycanopathy, and dystrophy associated with fukutin-related protein mutation; 3 with Becker muscular dystrophy; and 9 with idiopathic inflammatory myopathies, including polymyositis, dermatomyositis, and sporadic inclusion body myositis. Analysis of T1 images enabled us to describe the most affected muscles and the muscles usually spared for each muscular disease. In particular, examination of pelvis, thigh, and leg muscles demonstrated significant differences between the muscular diseases. On STIR images, hyperintensities were present in 62% of our patients with muscular dystrophies. A specific pattern of muscular involvement was established for each muscular disease. Hyperintensities observed on STIR images precede fatty degeneration and are not specific for inflammatory myopathies. (orig.)

  15. Upper Body Muscular Endurance Among Children 2-5 Years.

    Science.gov (United States)

    Gabbard, Carl P.; And Others

    The upper body muscular endurance of males and females 2-5 years of age was assessed, and relationships relative to sex, age, endurance and selected anthropometric measures were investigated. None of the relationships were found to be of practical predicative value; while upper body muscular strength increased with age, no significant differences…

  16. Primary muscular hydatid: preoperative diagnosis Throught computerized tomography and ultrasonography

    International Nuclear Information System (INIS)

    Macho Fernandez, J.M.; Marin Cardenas, M.A.; Mazas Artasona, L.; Lample Lacasa, C.; Otero Sierra, C.; Hernandez Navarrete, M.J.; Gomez-Pereda, R.

    1995-01-01

    Primary muscular hydatid disease, is extremely rare,- but not exceptional-, comparatively with other atypical localization. In this article the authors revised 474 patients with hydatid disease over a ten years period. Three cases of primary muscular localization were found. The ultrasonography and computed tomography facilitates the preoperative diagnosis. (Author) 40 refs

  17. Muscular hamartoma of the breast: a case report

    International Nuclear Information System (INIS)

    Kang, Byeong Seong; Park, Jeong Mi

    2002-01-01

    Muscular hamartoma is a variant of breast hamartoma shown at microscopic examination to be composed of abundant smooth muscle cells. We report a case of muscular hamartoma occurring in a 35-year-old woman with an incidentally discovered breast mass, and confirmed by excisional biopsy. We also describe the radiologic and pathologic findings

  18. EVALUACIÓN QUIMICA DE LA FIBRA EN SEMILLA, PULPA Y CÁSCARA DE TRES VARIEDADES DE AGUACATE

    Directory of Open Access Journals (Sweden)

    ADELA MARÍA CEBALLOS P

    Full Text Available El sector agropecuario colombiano requiere integrarse al sector agroindustrial para aumentarle valor a sus productos y residuos. Utilizar residuos agrícolas y agroindustriales como materias primas para obtener metabolitos secundarios es tema de interés en investigación y busca dar respuestas al uso de esos residuos, mediante desarrollo de tecnologías aplicables al entorno colombiano. Se valoraron cáscara, semilla y pulpa de aguacate variedades Booth8, Trinidad y Papelillo en estados de madurez fisiológica (MF y consumo (MC. Se hizo caracterización bromatológica, contenido de fibra como carbohidratos solubles (CHOS, lignina LG, celulosa y hemicelulosa (CEL y HEMICEL y fibra bruta (FB según (Tappi Methods 1993, 1998, AOAC, 2001. Los resultados fueron analizados mediante ANOVA (P < 0,05 utilizando SAS V9.1. Los CHOS en los dos estados de madurez y para las tres variedades variaron entre 12-38% cáscara, 20-35% pulpa y 17-35% semilla; CEL y HEMICEL 8-50% cáscara, 7-26% pulpa, 1-5% semilla, los cuales pueden ser útiles como complementos de procesos biotecnológicos. La pulpa de las tres variedades tiene alto valor nutricional por sus contenidos de proteína, fibra y minerales. La composición de la cáscara y semilla podrían ser importantes para suplementos de dieta animal o como recuperador de suelos para la producción agrícola

  19. La fibra óptica y el fenómeno no lineal mezcla de cuarta onda

    Directory of Open Access Journals (Sweden)

    Fabián Gómez López

    2015-12-01

    Full Text Available RESUMEN Para aprovechar de mejor manera el ancho de banda que tiene la fibra óptica, los sistemas de comunicaciones ópticos han tenido que aumentar la potencia de transmisión de las señales para poder transportar a grandes distancias la información. Debido a lo anterior, comienzan a producirse ciertos fenómenos ópticos no lineales como la mezcla de cuarta onda (Four Wave Mixing, FWM, que degradan la señal de información. En este documento se realiza un estado del arte de la fibra óptica y un estudio del fenómeno no lineal FWM, que se genera cuando dos o más señales ópticas se propagan en la fibra, lo cual conlleva a una mezcla de señales que puede generar nuevos componentes de interferencia de la señal óptica transmitida. ABSTRACT To make better use of the bandwidth that has the optical fiber, optical communications systems have had to increase the transmission power of signals to transport information over long distances. Because of this, certain nonlinear optical phenomena such as four wave mixing (Four Wave Mixing, FWM, which degrade the information signal begin to occur. Herein a state of the art of optical fiber and a study of the nonlinear FWM phenomenon, which is generated when two or more optical signals propagating in the fiber takes place, which leads to a mixture of signals that can generate new components interference of the transmitted optical signal.

  20. Caracterización de morteros de yeso reforzados con fibras recuperadas de eslingas textiles de un solo uso.

    OpenAIRE

    Tasán Cruz, Dany Marcelo

    2012-01-01

    Este trabajo estudia el comportamiento de conglomerantes a base de yeso agregados con Residuos de Construcción y demolición (RCD) como fibras recuperadas de eslingas textiles de un solo uso, incorporadas en tres porcentajes y comparando con una muestra de referencia.Las eslingas textiles de un solo uso, tienen como origen, dos obras situadas en la Comunidad de Madrid (Centro de Neurociencias Ramón y Cajal) y la Comunidad de Castilla la Mancha (Nuevo Hospital de Cuenca). Han sido estudiadas...

  1. Estudo do comportamento fotofísico de prepregs de fibra de vidro e resina fenólica.

    OpenAIRE

    Rogério da Silva Rosa

    2007-01-01

    O objetivo desse trabalho é a aplicação da Espectroscopia de Luminescência em modo estacionário para o estudo do processo de cura de pré-impregnados (prepregs) de fibra de vidro e resina fenólica, tratadas termicamente em três diferentes temperaturas 90, 120 e 150 C. O processo de cura dos prepregs também foi monitorado por Espectroscopia de absorção na região do Infravermelho com transformada de Fourier (FT-IR). Os espectros de luminescência dos prepregs mostram mudanças significativas atrib...

  2. Medición de microdeformaciones en losas viales usando sensores de redes de Bragg en fibras ópticas

    OpenAIRE

    Vélez-Hoyos, Francisco Javier; Serpa-Imbet, Claudia Milena; Gómez-Cardona, Nelson Darío

    2010-01-01

    En este trabajo se presenta un método no invasivo para la medición de microdeformaciones en estructuras de concreto usando sensores de redes de Bragg en fibras ópticas adheridos a su superficie. Se realizan mediciones en losas viales de concreto bajo una carga estática de 10 kN, encontrándose una relación aproximada de 2 : 1 entre la deformación registrada por los sensores y los valores arrojados por una simulación computacional con el método de elementos finitos. Se propone el uso de estos s...

  3. Comportamiento del hormigón con áridos siderúrgicos (EAF) reforzado con fibras

    OpenAIRE

    Fuente Alonso, José Antonio de la

    2016-01-01

    La investigación que recoge la presente Tesis Doctoral desarrolla un estudio experimental para obtener hormigones destinados a pavimentos y/o soleras utilizando como áridos los residuos generados en la fabricación de acero en hornos eléctricos de arco, escoria negra EAF, y reforzándolo con fibras metálicas o sintéticas. El objetivo principal es la elaboración de un hormigón siderúrgico, utilizando escoria negra de horno eléctrico de arco EAF como sustitución de los áridos naturales en un 7...

  4. Incremento de productividad en la producción de fibras acrílicas mediante la mejora de procesos.

    OpenAIRE

    Zabarburu Chuquizuta, Segundo Jose; Zabarburu Chuquizuta, Segundo Jose; Zabarburu Chuquizuta, Segundo Jose

    2012-01-01

    Vivimos en la época de la globalización, en donde no existen fronteras económicas, con mercados altamente competitivos, los cuales obligan a las empresas a realizar innovaciones tecnológicas, mejorar sus procesos, reducir sus costos y mejorar su calidad para lograr precisamente ser más competitivos. En este sentido la empresa Sudamericana de Fibras S.A. busca optimizar sus procesos y el uso de sus recursos. El siguiente trabajo de tesis está basado en la modificación de procesos que tra...

  5. Genetic modifiers of Duchenne and facioscapulohumeral muscular dystrophies.

    Science.gov (United States)

    Hightower, Rylie M; Alexander, Matthew S

    2018-01-01

    Muscular dystrophy is defined as the progressive wasting of skeletal muscles that is caused by inherited or spontaneous genetic mutations. Next-generation sequencing has greatly improved the accuracy and speed of diagnosis for different types of muscular dystrophy. Advancements in depth of coverage, convenience, and overall reduced cost have led to the identification of genetic modifiers that are responsible for phenotypic variability in affected patients. These genetic modifiers have been postulated to explain key differences in disease phenotypes, including age of loss of ambulation, steroid responsiveness, and the presence or absence of cardiac defects in patients with the same form of muscular dystrophy. This review highlights recent findings on genetic modifiers of Duchenne and facioscapulohumeral muscular dystrophies based on animal and clinical studies. These genetic modifiers hold great promise to be developed into novel therapeutic targets for the treatment of muscular dystrophies. Muscle Nerve 57: 6-15, 2018. © 2017 Wiley Periodicals, Inc.

  6. Why is muscularity sexy? Tests of the fitness indicator hypothesis.

    Science.gov (United States)

    Frederick, David A; Haselton, Martie G

    2007-08-01

    Evolutionary scientists propose that exaggerated secondary sexual characteristics are cues of genes that increase offspring viability or reproductive success. In six studies the hypothesis that muscularity is one such cue is tested. As predicted, women rate muscular men as sexier, more physically dominant and volatile, and less committed to their mates than nonmuscular men. Consistent with the inverted-U hypothesis of masculine traits, men with moderate muscularity are rated most attractive. Consistent with past research on fitness cues, across two measures, women indicate that their most recent short-term sex partners were more muscular than their other sex partners (ds = .36, .47). Across three studies, when controlling for other characteristics (e.g., body fat), muscular men rate their bodies as sexier to women (partial rs = .49-.62) and report more lifetime sex partners (partial rs = .20-.27), short-term partners (partial rs = .25-.28), and more affairs with mated women (partial r = .28).

  7. Resistência à compressão de argamassas em função da adição de fibra de coco

    OpenAIRE

    Silva,Everton J. da; Silva,Paola D. da; Marques,Maria L.; Fornari Junior,Celso C. M.; Garcia,Fermin C.; Luzardo,Francisco H. M.

    2014-01-01

    Neste trabalho se propôs analisar a influência que a variação do comprimento da fibra de coco exerce na resistência à compressão da argamassa, em busca de se determinar, experimentalmente, o comprimento mais próximo ao tamanho crítico. Foram confeccionadas argamassas com adição (0,3% em relação ao volume total da mistura) de 6 comprimentos diferentes de fibras de coco: 12,5; 25,0; 37,5; 50,0; 62,5 e 75,0 mm, além de uma argamassa de referência sem adição de fibra de coco. Para a avaliação do ...

  8. Estado del arte sobre el comportamiento físico-mecánico de la escayola reforzada con fibras de vidrio E

    Directory of Open Access Journals (Sweden)

    Comino Almenara, Pablo

    2004-10-01

    Full Text Available This article contains a discussion of the results and conclusions obtained in different studies to determine the physical and mechanical performance of fibre-reinforced plaster/scagliola specimens. The reinforcement used in this case is short filaments of fibreglass-E, the type of fibre most widely used at this time in Spain to reinforce prefabricated plaster/scagliola.En este artículo se presentan los resultados y las conclusiones obtenidas en diferentes estudios, sobre el comportamiento físico y mecánico, realizados en probetas de yeso/escayola reforzadas mediante la incorporación de fibras, y, en concreto, de fibras de vidrio E, en formato de hilos cortados. Este tipo de fibras son las más utilizadas en la actualidad para el refuerzo en prefabricados de yeso/ escayola, en España.

  9. Atrofia muscular espinal en el niño Spinal muscular atrophy present in children

    Directory of Open Access Journals (Sweden)

    Nicolás Garófalo Gómez

    2009-09-01

    Full Text Available INTRODUCCIÓN. Las atrofias musculares espinales en la infancia (AME son trastornos genéticos autosómicos recesivos, caracterizados por degeneración de las motoneuronas espinales y bulbares. El presente estudio tuvo el objetivo principal de describir las principales características clínicas en una serie de niños con AME. MÉTODOS. Se realizó un estudio retrospectivo de los pacientes con AME atendidos en el Instituto de Neurología y Neurocirugía de Cuba, entre enero de 1997 y diciembre de 2001. Se recopilaron los datos de 35 pacientes, 4 de ellos, fetos con confirmación prenatal de AME. Se precisaron las principales características clínicas, electromiográficas, de la biopsia muscular y de los estudios genéticos moleculares realizados en cada caso. RESULTADOS. La AME de tipo II resultó la forma clínica más frecuente (58 %, seguida por la AME de tipo I (42 %. Las principales manifestaciones clínicas resultaron la debilidad muscular generalizada con predominio proximal en extremidades, asociada a hipotonía y arreflexia osteotendinosa. La deleción de los exones 7 y 8 del gen SMN1 se detectó en 20 de 23 casos estudiados (87 %.INTRODUCTION: Spinal muscular atrophies (SMA in childhood are autosomal recessive genetic disorders, characterized by spinal and bulbar motoneurons degenerations. Aim of present paper was to describe the main clinical features in a series of children presenting SMA. METHODS: A retrospective study of patients with SMA seen in the Neurology and Neurosurgery Institute of Cuba from January, 2997 and December, 2001 was made. Data from 35 patients were available; four of them were fetus with prenatal confirmation of SMA. Main clinical, electromyography, muscular biopsy, and of molecular genetic studies performed in each case were determined. RESULTS: Type II SMA was the more frequent clinical presentation (58%, followed by type I SMA (42,%. Main clinical manifestations were a systemic muscular weakness with

  10. Signs and symptoms of Duchenne muscular dystrophy and Becker muscular dystrophy among carriers in the Netherlands : a cohort study

    NARCIS (Netherlands)

    Hoogerwaard, EM; Bakker, E; Ippel, PF; Oosterwijk, JC; Majoor-Krakauer, DF; Leschot, NJ; Van Essen, AJ; Brunner, HG; van der Wouw, PA; Wilde, AAM; de Visser, Marianne

    1999-01-01

    Background Carriers of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) may show muscle weakness or dilated cardiomyopathy. Studies focusing on skeletal-muscle involvement were done before DNA analysis was possible. We undertook a cross-sectional study in a population of

  11. Signs and symptoms of Duchenne muscular dystrophy and Becker muscular dystrophy among carriers in The Netherlands: a cohort study

    NARCIS (Netherlands)

    Hoogerwaard, E. M.; Bakker, E.; Ippel, P. F.; Oosterwijk, J. C.; Majoor-Krakauer, D. F.; Leschot, N. J.; van Essen, A. J.; Brunner, H. G.; van der Wouw, P. A.; Wilde, A. A.; de Visser, M.

    1999-01-01

    BACKGROUND: Carriers of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) may show muscle weakness or dilated cardiomyopathy. Studies focusing on skeletal-muscle involvement were done before DNA analysis was possible. We undertook a cross-sectional study in a population of

  12. Comportamiento mecánico y dinámico de una mezcla asfáltica con adición de fibras

    Directory of Open Access Journals (Sweden)

    Oscar Javier Reyes Ortiz

    2005-01-01

    Full Text Available El artículo refiere el análisis experimental en el laboratorio, del efecto de la adición de fibras de polipropileno por vía seca (reemplazo de material granular por fibra sobre las propiedades mecánicas y dinámicas de una mezcla. Inicialmente se caracteriza el material granular y asfalto CA60/70, se realiza el diseño de la mezcla asfáltica de granulometría 0/10 (IDU RSV 2002 y asfalto de acuerdo con la metodología Marshall; se evalúa el efecto de fibras sobre las propiedades mecánicas mediante la evaluación de la estabilidad y fluencia, y dinámicamente por su valor de deformación permanente y modulo dinámico. Los resultados muestran un efecto positivo de las fibras en la modificación de la mezcla asfáltica. El modulo dinámico aumenta en un 45% promedio en un porcentaje de adición de 0.60%; la deformación permanente disminuye en 27.6% para una adición de fibras de 0.60% y 48.8% para la adición de fibras de 0.75%, respectivamente. Este comportamiento refleja otra alternativa eficaz para mejorar la mezcla asfáltica, aumentando la resistencia a la disgregación por efecto abrasivo del tráfico y retardando el inicio y propagación del agrietamiento por ahuellamiento

  13. Para-muscular and trans-muscular approaches to the lumbar inter-vertebral foramen: an anatomical comparison.

    Science.gov (United States)

    Poetscher, Arthur Werner; Ribas, Guilherme Carvalhal; Yasuda, Alexandre; Nishikuni, Koshiro

    2005-03-01

    Foraminal and extra-foraminal disc herniations comprise up to 11.7% of all lumbar disc herniations. Facetectomy, which had been the classic approach, is now recognized as cause of pain and instability after surgery. Otherwise, posterior lateral approaches through a trans-muscular or a para-muscular technique offer no significant damage to key structures for spinal stability. The surgical anatomy of these approaches has already been described, but they were not compared. In order to quantify the angle of vision towards the intervertebral foramen offered by each technique, 12 fresh cadavers were dissected and studied regarding these approaches. The angle presented by trans-muscular approach was wider in all studied lumbar levels. Surgery through the trans-muscular approach is performed with a better working angle, requiring a smaller resection of surrounding tissues. Therefore, minor surgical trauma can be expected. Our measurements support previously published data that point the trans-muscular approach as the best surgical option.

  14. Produção de biscoitos extrusados de polvilho azedo com fibras: efeito de parâmetros operacionais sobre as propriedades físicas

    OpenAIRE

    Camargo,Karina Fernandes de; Leonel,Magali; Mischan,Martha Maria

    2008-01-01

    Neste trabalho buscou-se avaliar o efeito de parâmetros operacionais do processo de extrusão no desenvolvimento de biscoitos de polvilho com fibras, utilizando como matérias-primas o polvilho azedo e o farelo de mandioca. O processamento foi realizado em um extrusor mono-rosca, sendo considerados parâmetros variáveis: temperatura na 3ª zona de extrusão, umidade e porcentagem de fibras na mistura. Para analisar o efeito combinado das variáveis independentes nas características tecnológicas dos...

  15. Consumo de fibra dietética en lactantes menores de 2 años y estreñimiento funcional

    OpenAIRE

    Velasco Benítez, Carlos Alberto; Giraldo Lora, Sandra Carolina

    2015-01-01

    Antecedentes. La inclusión de la fibra dietética (FD), tiene múltiples beneficios sobre la salud del ser humano; sin embargo, en pediatría, existen grandes brechas concernientes a la relación de fibra y estreñimiento. Objetivo. Describir el hábito intestinal en lactantes . Se tuvo en cuenta la alimentación con leche materna, el tiempo de inicio de alimentación complementaria y el antecedente de madre o cuidador con EF. Los resultados son expresados como promedio ± desviación estándar. El anál...

  16. Elaboración y caracterización estructural de fibras de tereftalato de polietileno (PET) dopadas con nanocobre (0) utilizando proceso de extrusión

    OpenAIRE

    Guzman, A.; Cárcamo, H.; León, O.

    2015-01-01

    El presente estudio describe la elaboración y caracterización de una fibra sintética bactericida compuesta por Tereftalato de Polietileno reciclado (rPET) y nanopartículas de cobre (0), mediante un proceso de extrusión utilizando una extrusora monohusillo. Las nanopartículas empleadas fueron elaboradas utilizando radiación microondas y ultrasonido. Para la elaboración de la fibra se produce un masterbatch de rPET con polvo de cobre nanométrico empleando un solvente de alto punto de fusión (tr...

  17. Metodología para el diseño óptimo de dovelas de hormigón reforzado con fibras

    OpenAIRE

    Fuente Antequera, Albert de la; Pujadas Álvarez, Pablo; Blanco Álvarez, Ana; Aguado de Cea, Antonio

    2012-01-01

    En este trabajo se presentan una de las experiencias más relevantes relativas al uso de fibras estructurales como refuerzo del hormigón substitución prácticamente toda la armadura pasiva tradicional en dovelas para anillos de revestimiento en el área metropolitana de Barcelona. Es conocido, que la adición de fibras estructurales mejora, por una parte, la respuesta estructural del elemento durante su construcción, especialmente durante la acción del empuje de los gatos, y, por otra parte, cond...

  18. Sintesis in situ de nanopartículas de peróxido de zinc sobre fibras de plátano con potencial en la industria textil

    OpenAIRE

    María Estefanía Ballesteros García; John Ricardo Jr. Duran Romero; Juliana Gutiérrez Corrales; Alis Pataquiva-Mateus

    2017-01-01

    El presente trabajo de investigación plantea un desarrollo entorno al manejo de residuos en los cultivos de plátano, siendo una idea sostenible con respecto a la extracción y adquisición de fibras con cualidades innovadoras que posean nanopartículas (NPs) de ZnO2 como la capacidad antimicrobiana. La finalidad de la investigación fue la de nanoestructurar fibras provenientes de residuos del plátano con NPs de peróxido de zinc como una propuesta sostenible, teniendo en cuenta factores de optimi...

  19. Construção e caracterização de um amplificador em fibra para pulsos ultracurtos em ʎ = 1.5 um

    OpenAIRE

    ARIAS, Luis Alfredo Giraldo

    2014-01-01

    Lasers de pulsos ultracurtos baseados em fibras ópticas como meio de ganho constituem fortes candidatos para substituir lasers de estado sólido mais tradicionais, tais como o laser de Ti:safira. Uma das razões é o custo direto e outra é a possibilidade de compactação de sistemas que ocupam muito espaço e consomem quantidades significativas de energia. Um dos problemas de lasers baseados em fibras ópticas é que a potência óptica média disponível é relativamente baixa, da ordem d...

  20. Estudo da flamabilidade e resistência à chama de compósito de poliéster insaturado e fibra da folha do abacaxizeiro (PALF)

    OpenAIRE

    Ribeiro, Luciene Mendes

    2011-01-01

    Na presente pesquisa foram desenvolvidos compósitos com fibras da folha do abacaxizeiro (PALF - Pineapple Leaf Fiber), utilizando resina de poliéster insaturado como matriz, incorporando retardante de chama em diferentes composições. As fibras da folha do abacaxizeiro foram obtidas na ramada 4 do município de Ielmo Marinho no Estado do Rio Grande do Norte. A resina de poliéster insaturado e o catalisador foram comprados no comércio. O retardante de chama de alumina trihidratada (hidróxido de ...

  1. Contribución al desarrollo de sensores de temperatura y redes de sensores en tecnología de fibra óptica

    OpenAIRE

    Madruga Saavedra, Francisco Javier

    2006-01-01

    Este trabajo de tesis recoge las contribuciones aportadas en el campo de los sensores de fibra óptica en tres ámbitos de trabajo. Un sistema sensor de alta temperatura sin contacto con transductores de fibras ópticas de sílice se ha presentado. Dos topologías de "ojo abierto" y "ojo cerrado" y un algoritmo de decodificación "pirometría de banda dual" propuesto en este trabajo son las novedosas aportaciones presentadas. El sistema ha sido validado en laboratorio y en pruebas de campo de forma ...

  2. Contribución al desarrollo de sensores de temperatura y redes de sensores en tecnología de fibra óptica

    OpenAIRE

    Madruga Saavedra, Francisco Javier

    2008-01-01

    RESUMEN: Este trabajo de tesis recoge las contribuciones aportadas en el campo de los sensores de fibra óptica en tres ámbitos de trabajo. Un sistema sensor de alta temperatura sin contacto con transductores de fibras ópticas de sílice se ha presentado. Dos topologías de "ojo abierto" y "ojo cerrado" y un algoritmo de decodificación "pirometría de banda dual" propuesto en este trabajo son las novedosas aportaciones presentadas. El sistema ha sido validado en laboratorio y en pruebas de campo ...

  3. Eventos adversos temporalmente asociados a VAMENGOC- BC®. Municipio La Lisa, 1998-1999

    Directory of Open Access Journals (Sweden)

    Iván Edelberto Cuevas

    2000-12-01

    Full Text Available Con el objetivo de describir la frecuencia de eventos temporalmente asociados a la vacuna cubana VAMENGOC- BC®, se realizó un estudio observacional de tipo descriptivo, cuyo universo estuvo constituido por los lactantes en las edades comprendidas de tres (3549 y cinco meses (3832 de edad de las áreas de salud del Municipio La Lisa en Ciudad de La Habana. Hubo un 3,21% de niños con eventos adversos, con una mayor frecuencia después de la primera dosis; sin diferencias apreciables por sexo. La clasificación fue de un 52% de tipo sistémico, locales un 19% y no solicitados un 29%. La mayor parte de los niños afectados fue en las primeras 72 horas posteriores a la vacunación, y desaparecieron antes de 72 horas desde su comienzo. Las manifestaciones más frecuentes fueron fiebre (predominó entre todos los eventos adversos con 1,53 casos por 100 vacunados; la induración (0,31 por 100 vacunados, eritema (0,30 por 100 vacunados y el dolor (0,136 por 100 vacunados en el sitio de administración de la vacuna; irritabilidad (0,244 por 100 vacunados y pérdida de apetito (0,311 por 100 vacunados. Los eventos no solicitados más frecuentes fueron la Enfermedad Respiratoria Aguda (0,637 por 100 vacunados, la Enfermedad Diarreica Aguda (0,311 por 100 vacunados y la Otitis Media (0,176 por 100 vacunados. Los eventos adversos serios fueron infrecuentes. No hubo fallecidos y todos los casos se recuperaron en menos de diez días, sin secuelas, discapacidades ni minusvalías

  4. Serum creatinine level: a supplemental index to distinguish Duchenne muscular dystrophy from Becker muscular dystrophy.

    Science.gov (United States)

    Zhang, Huili; Zhu, Yuling; Sun, Yiming; Liang, Yingyin; Li, Yaqin; Zhang, Yu; Deng, Langhui; Wen, Xingxuan; Zhang, Cheng

    2015-01-01

    To improve assessment of dystrophinopathy, the aim of this study was to identify whether serum creatinine (Crn) level reflects disease severity. Biochemical, Vignos score, and genetic data were collected on 212 boys with dystrophinopathy. Serum Crn level had a strong inverse correlation with Vignos score by simple correlation (r = -0.793) and partial correlation analysis after adjustment for age, height, and weight (r = -0.791; both P Becker muscular dystrophy (BMD) patients than Duchenne muscular dystrophy (DMD) patients at ages 4, 5, 7, and 9 yr (all P < 0.0125). After adjusting for age, height, and weight, BMD patients still had a significantly higher serum Crn level than DMD patients (β = 7.140,  t = 6.277,  P < 0.01). Serum Crn level reflected disease severity and may serve as a supplemental index to distinguish DMD from BMD in clinical practice.

  5. Guidelines for the Perianesthesia Care of the Duchenne Muscular Dystrophy/Becker Muscular Dystrophy Patient.

    Science.gov (United States)

    Alliod, Barbara A; Ash, Rebecca A

    2016-12-01

    More patients suffering with Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are presenting to perianesthesia settings for emergent and nonemergent treatment and care. A group of collaborative health care providers at Rush University Medical Center in Chicago developed a multidisciplinary DMD/BMD Task Force to study this disorder and create a set of guidelines to aid those engaging in the planning, execution of care, and recovery of this unique population in the perianesthesia setting. Attention to detail, well-executed preplanning, meticulous awareness of the patient, and prearranged implementation and intervention has proven to offset potential problems and complications and is the key to a successful perianesthesia period. Copyright © 2016 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.

  6. Muscular response to the first three months of deflazacort treatment in boys with Duchenne muscular dystrophy

    DEFF Research Database (Denmark)

    Jensen, L; Petersson, S J; Illum, N O

    2017-01-01

    OBJECTIVE: Duchenne muscular dystrophy (DMD) patients are often treated with glucocorticoids; yet their precise molecular action remains unknown. METHODS: We investigated muscle biopsies from nine boys with DMD (aged: 7,6±2,8 yrs.) collected before and after three months of deflazacort treatment...... into the molecular actions of glucocorticoids in DMD at the mRNA level, and we show that multiple regulatory pathways are influenced. This information can be important in the development of new treatments....

  7. Pain in adolescents with spinal muscular atrophy and Duchenne and Becker muscular dystrophy.

    Science.gov (United States)

    Lager, Christina; Kroksmark, Anna-Karin

    2015-09-01

    The purpose of this study was to explore the prevalence, nature and scope of pain in adolescents with spinal muscular atrophy and Duchenne and Becker muscular dystrophy and whether the pain differs between diagnostic groups or between adolescents with different ambulation status. Furthermore to study the consequences of pain and to identify pain-exacerbating and pain-relieving factors. In a national survey, fifty-five adolescents with spinal muscular atrophy and dystrophinopathy completed a questionnaire assessing pain frequency, duration, location using a body map, intensity and discomfort using visual analogue scales, pain interference using a modified version of Brief Pain Inventory and factors exacerbating and relieving pain. Sixty-nine per cent of the adolescents reported pain during the past three months and 50% reported chronic pain. The pain prevalence did not differ significantly between diagnostic groups or between ambulators and non-ambulators. The average pain intensity was graded as mild and the worst pain as moderate. The pain typically occurred weekly, most frequently in the neck/back or legs. General activity and mood were the areas that were most affected by pain. Common pain-exacerbating factors were sitting, too much movement/activity and being lifted or transferred. Pain is a frequent problem in adolescents with spinal muscular atrophy and dystrophinopathy. The assessments used enable an understanding both of the nature and scope of pain and of the impact of pain in everyday life. The study highlights the importance of assessing pain in a systematic manner and offering an individual approach to interventions designed to reduce pain in this population. Copyright © 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

  8. Fibras vegetais utilizadas na pesca artesanal na microrregião do Salgado, Pará

    Directory of Open Access Journals (Sweden)

    Jorge Oliveira

    Full Text Available As espécies vegetais fibrosas ocupam papel de destaque no cotidiano das comunidades tradicionais amazônicas ao lado das espécies medicinais, alimentícias e madeireiras. Na microrregião do Salgado do estado do Pará - constituída pelos municípios de Colares, Curuçá, Magalhães Barata, Maracanã, Marapanim, Salinópolis, Santarém Novo, São Caetano de Odivelas, São João de Pirabas e Vigia - as fibras vegetais são usadas em cestaria, trançados, fixadoras em substituição ao prego, adornos e vestuário. Para a elaboração do presente trabalho, os dados foram obtidos entre artesãos e pescadores artesanais da microrregião do Salgado do estado do Pará, com cerca de 150 entrevistas semiestruturadas. Foram registradas 17 espécies, distribuídas em oito famílias e 17 gêneros utilizados na preparação de implementos de pesca artesanal, cujas matérias prima são provenientes de diversas partes da planta, onde as talas são da haste caulinar de Marantaceae e estipe de Arecaceae, os cipós são raízes de Araceae e Cyclanthaceae e os caules de Bignoniaceae e Dilleniaceae, enquanto que as palhas são folhas e pinas de Arecaceae. A família mais representativa com relação ao número de espécies e o fornecimento de matéria prima utilizada foi Arecaceae com 8 spp., seguida de Dilleniaceae e Araceae com 2 spp., Bignoniaceae, Bombacaceae, Cyclanthaceae, Marantaceae e Poaceae com 1 sp. cada. O trabalho visa contribuir para o conhecimento das espécies vegetais fibrosas, quanto a sua morfologia, origem e manuseio da matéria prima, os produtos confeccionados e seus usos, além do registro dos aspectos culturais da utilização de espécies vegetais fibrosas no cotidiano da atividade pesqueira artesanal daquela microrregião.

  9. Fibroblast cultures in duchenne muscular dystrophy

    International Nuclear Information System (INIS)

    Ionasescu, V.; Lara-Braud, C.; Zellweger, H.; Ionasescu, R.; Burmeister, L.

    1977-01-01

    Primary skin fibroblast cultures were grown from forearm pinch skin biopsies obtained from 24 patients with Duchenne muscular dystrophy (DMD) and ten normal controls matched for sex and age. The first subcultures were grown for 7 days and incubated with L-( 3 H)-proline for 24 hours. Intracellular collagen incoption was significantly decreased (2.2 X) and extracellular collagen incorporation significantly increased (1.8 X) in fibroblast cultures from patients with DMD by both collagenase assay and polyacrylamide gel electrophoresis. The synthesis of noncollagen proteins showed low values from the DMD fibroblast cultures. The alterations in synthesis and secretion of collagen and noncollagen proteins were characteristic only for the log phase of DMD fibroblasts. (author)

  10. Natural history of Duchenne muscular dystrophy

    Directory of Open Access Journals (Sweden)

    Qing KE

    2015-05-01

    Full Text Available Duchenne muscular dystrophy (DMD is X-linked recessive hereditary disease. DMD gene mutations result in dystrophin deficiency, which causes not only muscle movement disorders but also scoliosis, cognitive dysfunction, urinary tract diseases, respiratory diseases and heart diseases. Most patients die in early adult for respiratory and circulatory failure. Early multidisciplinary therapies will significantly delay disease progression and improve patients' quality of life. However, DMD diagnosis and treatment exist significantly time delay now. In this study, we review the natural history of DMD, including motor, cognitive, respiratory and heart function, for improving DMD early recognition, diagnosis and treatment, so as to benefit DMD patients. DOI: 10.3969/j.issn.1672-6731.2015.05.004

  11. Hardware reconfigurable para la reconstrucción de videos transmitidos por un mazo de fibras incoherente

    Directory of Open Access Journals (Sweden)

    Pablo Montejo Valdés

    2013-04-01

    Full Text Available La transmisión de imágenes mediante mazos de fibras ópticas no coherentes (IOFB necesita información sobre la posición de cada fibra para ser usada en la reconstrucción de la imagen original. Otro importante requerimiento es poseer suficiente memoria para almacenar la imagen durante su reconstrucción y durante su retransmisión. La mayoría de las veces estos aspectos obligan el uso de memoria externa si se utilizan FPGAs en el sistema. Este trabajo presenta una solución a este problema. Se propone un sistema en un chip capaz de almacenar la información necesaria y las imágenes sobre las que se está trabajando usando un FPGA de bajo costo. Se presentan dos soluciones y se implementa la que resulta más ventajosa. Los resultados son discutidos. El uso de este método hace posible transmitir  video usando IOFB y reconstruir las imágenes originales casi en tiempo real, debido a su baja latencia. Esta propuesta podría utilizarse en sistemas autónomos sacando ventaja de su nivel de compactación, fiabilidad y bajo costo.

  12. Application of unimodal optic fiber to communications among electric substations; Aplicacion de fibra optica unimodal a comunicaciones entre subestaciones electricas

    Energy Technology Data Exchange (ETDEWEB)

    Martinez Pinon, Fernando; Hernandez Juarez, Taide [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1992-07-01

    The utilization of the unimodal fiber optics technology in the electric power systems, represents one of the best communication options because of its multiple advantages, that results in a better coordination of the technical and administrative activities, needed to carry the electric energy from its generation site to the most remote locations. In this document a study, in accordance with the available options for the design of communication systems via unimodal optic fiber, is presented. With this technology, ties of more than 100 kilometers without the need of repeating stations, can be made. [Espanol] La utilizacion de la tecnologia de fibra optica unimodal en los sistemas electricos de potencia representa una de las mejores alternativas de comunicacion por sus multiples ventajas que se traducen en una mejor coordinacion de las acitividades tecnicas y administrativas necesarias para llevar la energia electrica desde el lugar de generacion hasta los puntos mas distantes. En este documento se presenta un estudio de acuerdo a las opciones disponibles para el diseno de sistemas de comunicacion por fibra optica unimodal. Con esta tecnologia se pueden realizar enlaces mayores que 100 km sin necesidad de repetidores.

  13. The Importance of Muscular Strength: Training Considerations.

    Science.gov (United States)

    Suchomel, Timothy J; Nimphius, Sophia; Bellon, Christopher R; Stone, Michael H

    2018-04-01

    This review covers underlying physiological characteristics and training considerations that may affect muscular strength including improving maximal force expression and time-limited force expression. Strength is underpinned by a combination of morphological and neural factors including muscle cross-sectional area and architecture, musculotendinous stiffness, motor unit recruitment, rate coding, motor unit synchronization, and neuromuscular inhibition. Although single- and multi-targeted block periodization models may produce the greatest strength-power benefits, concepts within each model must be considered within the limitations of the sport, athletes, and schedules. Bilateral training, eccentric training and accentuated eccentric loading, and variable resistance training may produce the greatest comprehensive strength adaptations. Bodyweight exercise, isolation exercises, plyometric exercise, unilateral exercise, and kettlebell training may be limited in their potential to improve maximal strength but are still relevant to strength development by challenging time-limited force expression and differentially challenging motor demands. Training to failure may not be necessary to improve maximum muscular strength and is likely not necessary for maximum gains in strength. Indeed, programming that combines heavy and light loads may improve strength and underpin other strength-power characteristics. Multiple sets appear to produce superior training benefits compared to single sets; however, an athlete's training status and the dose-response relationship must be considered. While 2- to 5-min interset rest intervals may produce the greatest strength-power benefits, rest interval length may vary based an athlete's training age, fiber type, and genetics. Weaker athletes should focus on developing strength before emphasizing power-type training. Stronger athletes may begin to emphasize power-type training while maintaining/improving their strength. Future research should

  14. Poliolefinas reforçadas com fibras vegetais curtas: sisal × curauá Polyolefins reinforced with short vegetal fibers: sisal vs. curauá

    Directory of Open Access Journals (Sweden)

    Márcia A. S. Spinacé

    2011-01-01

    Full Text Available É crescente o interesse nos compósitos poliméricos reforçados com fibras vegetais curtas em substituição às fibras de vidro, pois as fibras naturais provêm de fontes renováveis, não são abrasivas aos equipamentos de processamento, são biodegradáveis, e possuem baixa densidade comparada às fibras de vidro. Elas apresentam início de degradação em torno de 200 °C, sendo adequadas para reforçar poliolefinas que são processadas até essa temperatura ou termofíxos. Várias fibras vegetais vêm sendo usadas como reforço, dentre elas o curauá e o sisal; no entanto, há grande controvérsia na literatura sobre as propriedades finais dos compósitos. Neste trabalho comparamos as propriedades de compósitos de polietileno de alta densidade ou polipropileno com 20% em massa de fibras curtas de sisal ou de curauá com ou sem agentes de acoplagem. Todos foram processados por extrusão e moldados por injeção, exatamente nas mesmas condições, e os resultados foram comparados em termos das propriedades mecânicas. As fibras de curauá apresentam resistência à tração superior às fibras de sisal e os compósitos com fibras de curauá apresentaram resistência à tração e flexão ligeiramente superior aos compósitos com fibra de sisal. No caso da resistência ao impacto a situação se inverte. Como o sisal é mais frágil que o curauá, durante o processamento ocorre maior quebra da fibra provocando essa diferenciação nas propriedades mecânicas dos compósitos.There is growing interest in reinforced polymer composites using short vegetal fibers to replace glass fibers for several reasons. The composite fibers are produced from renewable resources, being biodegradable and less abrasive to the processing equipment, in addition to possessing a lower density than the glass fibers. Since their thermal degradation onset is at 200 °C, they can be used to reinforce thermoplastics processed below this temperature and thermosets

  15. Mapa de preferência de sorvetes ricos em fibras Preference map of high-fiber ice cream

    Directory of Open Access Journals (Sweden)

    Regiane Lopes de Sales

    2008-12-01

    Full Text Available Quatro amostras de sorvete foram preparadas adicionando-se diferentes concentrações de granola e Frutooligossacarídeo (FOS. Foi avaliado o teor de fibras segundo método AOAC. A avaliação da aceitabilidade sensorial foi realizada por 78 consumidores, com idade entre 15 e 25 anos. Estes avaliaram a aceitação global das formulações, utilizando a escala hedônica de nove pontos, em uma única seção, de forma monádica. O experimento foi estruturado segundo delineamento em blocos inteiramente casualizados. Os resultados foram submetidos à análise de variância, ao teste de médias de Tuckey e à metodologia do Mapa de Preferência interno para análise dos componentes principais. As amostras controle e as adicionadas de FOS tiveram melhor aceitação. A amostra contendo somente FOS foi a que mais se aproximou do produto tradicional, não diferindo significativamente quanto à aceitação global. A granola distinguiu-se estatisticamente do produto tradicional. O teor de fibras analisado foi superior ao fornecido pelo fabricante da granola. As concentrações de fibras nos sorvetes variaram de 0,9 a 5,45 g.100 g-1 de sorvete, com a maior concentração de fibras provenientes do FOS. Esse resultado permite concluir que o FOS é um ingrediente promissor no desenvolvimento de produtos ricos em fibras.Four samples of ice cream were prepared with four different concentrations of granola and fructooligosaccharide (FOS. The concentration of fiber was evaluated using the AOAC method. The acceptance evaluation was conducted by 78 consumers between 15 and 25 years of age. The consumers evaluated the global acceptance of the formulations through the structured 9-point hedonic scale, in a single section, in a monadic form. The experiment was structured by a Randomized Complete Block Design. The results were submitted to the analysis of variance, Tukey test, and to the preference mapping technique for principal component analysis. The control samples

  16. Genetics and emerging treatments for Duchenne and Becker muscular dystrophy.

    Science.gov (United States)

    Wein, Nicolas; Alfano, Lindsay; Flanigan, Kevin M

    2015-06-01

    Mutations in the DMD gene result in Duchenne or Becker muscular dystrophy due to absent or altered expression of the dystrophin protein. The more severe Duchenne muscular dystrophy typically presents around ages 2 to 5 with gait disturbance, and historically has led to the loss of ambulation by age 12. It is important for the practicing pediatrician, however, to be aware of other presenting signs, such as delayed motor or cognitive milestones, or elevated serum transaminases. Becker muscular dystrophy is milder, often presenting after age 5, with ambulation frequently preserved past 20 years and sometimes into late decades. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. CT finding and cerebrospinal fluid proteins in muscular dystrophy patients

    International Nuclear Information System (INIS)

    Hirase, Tsutomu; Ide, Masami; Araki, Shukuro; Okamoto, Hiroshi; Kawasaki, Shoichiro; Imamura, Shigehiro.

    1983-01-01

    We analyzed the microcomponents of protein fractions in the cerebrospinal fluid of patients with various types of muscular dystrophy. The degenerative pattern is characterized by an increase in the prealbumin and a decrease in the γ-globulin fraction is shown in the Duchenne and congenital muscular dystrophy. The increase in CSF IgG, γ-globulin fraction is shown in the myotonic dystrophy. In addition to the abnormality of IQ, EEG, and brain CT, abnormal CSF proteins obviously suggest the presence of CNS involvement in muscular dystrophy. (author)

  18. CT finding and cerebrospinal fluid proteins in muscular dystrophy patients

    Energy Technology Data Exchange (ETDEWEB)

    Hirase, Tsutomu; Ide, Masami; Araki, Shukuro; Okamoto, Hiroshi (Kumamoto Univ. (Japan). School of Medicine); Kawasaki, Shoichiro; Imamura, Shigehiro

    1983-06-01

    We analyzed the microcomponents of protein fractions in the cerebrospinal fluid of patients with various types of muscular dystrophy. The degenerative pattern is characterized by an increase in the prealbumin and a decrease in the ..gamma..-globulin fraction is shown in the Duchenne and congenital muscular dystrophy. The increase in CSF IgG, ..gamma..-globulin fraction is shown in the myotonic dystrophy. In addition to the abnormality of IQ, EEG, and brain CT, abnormal CSF proteins obviously suggest the presence of CNS involvement in muscular dystrophy.

  19. MR imaging of fukuyama congenital muscular dystrophy; a case report

    International Nuclear Information System (INIS)

    Yoo, Jeong Hyun; Kim, Yoo Kyung; Koo, Hae Soo; Park, Ki Deuk

    2000-01-01

    Fukuyama congenital muscular dystrophy is a genetic disease and common in Japan. The typical clinical features are hypotonia with an early infantile onset and severe developmental delay. The diagnosis is based on pathologic evidence of muscular dystrophy revealed by biopsy or an increased serum creatine kinase levels. Involvement of the brain is characterized by abnormal cerebral cortical dysplasia, cerebellar dysplasia, and white matter changes. We encountered a case of Fukuyama congenital muscular dystrophy in which brain MRI findings were typical, and present this case together with a review of the literature

  20. Resistance training in patients with limb-girdle and becker muscular dystrophies

    DEFF Research Database (Denmark)

    Sveen, Marie-Louise; Andersen, Søren P; Ingelsrud, Lina H

    2013-01-01

    In this study we investigated the effect of strength training in patients with limb-girdle muscular dystrophy (LGMD) and Becker muscular dystrophy (BMD).......In this study we investigated the effect of strength training in patients with limb-girdle muscular dystrophy (LGMD) and Becker muscular dystrophy (BMD)....

  1. [Supplementary device for a dynamometer to evaluate and register muscular endurance indices].

    Science.gov (United States)

    Timoshenko, D A; Bokser, O Ia

    1986-01-01

    In practice of psychophysiologic research muscular endurance index is used for estimation of CNS function. Muscular endurance index is defined as relative time needed for maintaining the preset muscular effort. The described device widens the possibilities of a digital dynamometer for automatic estimation and recording of muscular endurance index in real time.

  2. Treinamento aeróbico prévio à compressão nervosa: análise da morfometria muscular de ratos

    Directory of Open Access Journals (Sweden)

    Elisangela Lourdes Artifon

    2013-02-01

    Full Text Available INTRODUÇÃO: Ciatalgia origina-se da compressão do nervo isquiático e implica em dor, parestesia, diminuição da força muscular e hipotrofia. O exercício físico é reconhecido na prevenção e reabilitação de lesões, porém quando em sobrecargas pode aumentar o risco de lesões e consequente déficit funcional. OBJETIVO: Avaliar efeitos de treinamento aeróbico prévio a modelo experimental de ciatalgia em relação a parâmetros morfométricos dos músculos sóleos de ratos. MATERIAIS E MÉTODOS: 18 ratos divididos em três grupos: simulacro (mergulho, 30 segundos; exercício regular (natação, dez minutos diários; e treinamento aeróbico progressivo (natação em tempos progressivos de dez a 60 minutos diários. Ao final de seis semanas de exercício, os ratos foram submetidos ao modelo experimental da ciatalgia. No terceiro dia após a lesão, foram eutanasiados e tiveram seus músculos sóleos dissecados, pesados e preparados para análise histológica. Variáveis analisadas: peso muscular, área de secção transversa e diâmetro médio das fibras musculares. RESULTADOS: Observou-se diferença estatisticamente significativa para todos os grupos quando se comparou músculo controle e aquele submetido à lesão isquiática. A análise intergrupos não apresentou diferença estatisticamente significativa para nenhuma das variáveis analisadas. CONCLUSÃO: Tanto o exercício físico regular quanto o treinamento aeróbico não produziram efeitos preventivos ou agravantes às consequências musculares da inatividade funcional após ciatalgia.

  3. Concreto autoadensável reforçado com fibras de aço: comportamento à flexão

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    A. R. Barros

    Full Text Available Este estudo foi desenvolvido para avaliar o comportamento de vigas de concreto autoadensável (CAA reforçado com fibras de aço submetidas à flexão. Para tal, foram utilizadas fibras de aço com fator l/d = 50, em uma fração volumétrica de 1%. Foram confeccionadas vigas armadas de dimensões (12,5 x 23,5 x 132 cm, as quais foram ensaiadas por flexão a quatro pontos, aos 28 dias de idade, sendo feitas medições das deformações apresentadas nos estribos e armadura longitudinal, além de medições das deformações do concreto na região comprimida e das flechas no meio do vão. Os resultados dos ensaios mostraram que a adição das fibras de aço ao CAA promoveu sensível ganho na capacidade resistente da viga, com menores flechas, menores deformações das armaduras, longitudinal e transversal, e melhorado controle da fissuração, em comparação às demais vigas produzidas com concretos convencionais, com e sem fibras de aço.

  4. Fibras reforçadas por resina (FRC em Ortodontia. Versatilidade clínica: parte 2 Fiber reinforced composite (FRC in Orthodontic. Clinical versatility: part II

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    Daniel Ianni Filho

    2005-06-01

    Full Text Available As fibras de vidro e de polietileno podem ser utilizadas na prática ortodôntica em diversas situações clínicas, nos casos com ou sem extrações dentárias. Este artigo tem como objetivo mostrar algumas das aplicações clínicas nas quais as fibras contribuíram de forma significativa para a realização dos tratamentos ortodônticos, simplificando-os e aumentando a eficiência clínica. As fibras foram utilizadas principalmente em segmentos de ancoragem e na substituição da banda pela colagem da associação fibra/tubo nos molares.Glass and polyethylene fibers can be used in orthodontic practice on several clinical(s situations, in cases with or without teeth extraction. The objective of this article is to show some of the clinical applications in which the fibers contributed in a positive way to improve the performance of orthodontic treatments, simplifying and raiseing the clinical efficiency. These fibers were mainly used on anchorage segments, and as a substitute for the band by bonding the fiber/tube association in molars.

  5. EFEITO DE DIFERENTES TEMPOS DE COZIMENTO NOS TEORES DE FIBRAS ALIMENTARES EM FOLHAS DE BRÓCOLIS, COUVE-FLOR E COUVE (BRASSICA OLERACEA L.

    Directory of Open Access Journals (Sweden)

    Mônica Alessandra Teixeira dos SANTOS

    2009-07-01

    Full Text Available

    Foram determinados os teores de fibras alimentares (FDA, FDN, lignina e pectinas das folhas de brócolis e couve-flor e comparados aos teores encontrados nas tradicionais folhas de couve. Os materiais estudados foram cultivados no município de Ijaci MG, com o objetivo da utilização integral dessas hortaliças como fonte alternativa de fibras. As folhas foram submetidas a cocção por seis diferentes tempos (0, 2, 4, 6, 8 e 10 minutos. Acompanhando o comportamento das diversas frações da fibra no material úmido e após secagem. Os resultados mostraram que as folhas de couve-flor e brócolis superaram a couve comum, que apresentou teores superiores apenas na fração FDA do material seco. Os resultados revelaram que as folhas das hortaliças analisadas podem ser consideradas como boas fontes de fibras insolúveis, mas não contribuem significativamente com a porção solúvel.

  6. Sintesis in situ de nanopartículas de peróxido de zinc sobre fibras de plátano con potencial en la industria textil

    Directory of Open Access Journals (Sweden)

    María Estefanía Ballesteros García

    2017-09-01

    Full Text Available El presente trabajo de investigación plantea un desarrollo entorno al manejo de residuos en los cultivos de plátano, siendo una idea sostenible con respecto a la extracción y adquisición de fibras con cualidades innovadoras que posean nanopartículas (NPs de ZnO2 como la capacidad antimicrobiana. La finalidad de la investigación fue la de nanoestructurar fibras provenientes de residuos del plátano con NPs de peróxido de zinc como una propuesta sostenible, teniendo en cuenta factores de optimización en procesos para la síntesis de las nanopartículas. Los resultados más relevantes se obtuvieron en la prueba física microscopia electrónica de barrido (SEM, en donde se destaca el tamaño nanométrico de las partículas sintetizadas de 94 nm. Se demostró el factor hidrofóbico de las fibras de plátano por encima de las fibras de algodón.

  7. Análise quantitativa da camada de fibras nervosas da retina de cães normais e glaucomatosos através da polarimetria a laser

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    Ana Lucia Braga Martins

    2003-01-01

    Full Text Available As lesões glaucomatosas são progressivas e irreversíveis. Estudos sobre o aparecimento e comportamento desta enfermidade vêm sendo discutidos na oftalmologia em geral. O diagnóstico precoce é de extrema importância para o tratamento e estabilização da mesma. A análise da espessura da camada de fibras nervosas retinianas ''in vivo'' foi proposta na oftalmologia humana, para estabelecer as alterações produzidas pelo glaucoma, e tem demonstrado que tais alterações podem ser detectadas até seis anos antes de alterações de campo visual e aumento de pressão intraocular. Entretanto, na Medicina Veterinária, estes dados carecem de estudo e discussão. Neste experimento foram utilizados dois grupos de cães, com olhos normais e olhos glaucomatosos, que foram submetidos à análise das fibras nervosas retinianas através do Analisador de Fibras Nervosas GDx. Os resultados estatísticos demonstraram que a camada de fibras nervosas dos olhos dos cães glaucomatosos estava mais delgada (p < 0,05 quando comparados aos olhos de cães normais, confirmando a perda de axônios das células ganglionares em olhos de cães com glaucoma.

  8. Influência das fibras de aço e das adições minerais na fissuração de tirantes de concreto armado

    Directory of Open Access Journals (Sweden)

    L. A. Oliveira Júnior

    Full Text Available Neste trabalho é investigada a influência das fibras de aço e das adições minerais (sílica ativa e cinza volante na fissuração de tirantes de concreto armado. Fibras de aço com gancho nas extremidades e relação de aspecto igual a 65 foram usadas nas frações volumétricas de 0,75%, 1,00% e 1,50%. Dezesseis tirantes de 800 mm de comprimento e seção transversal quadrada de 150 mm de lado reforçados com uma barra de aço CA-50 de 20 mm de diâmetro foram submetidos à tração axial para determinação das aberturas das fissuras. Os resultados mostraram que as fibras reduziram a abertura média de fissuras em até 75% e que as adições minerais melhoraram o comportamento do concreto na fissuração. As aberturas de fissuras foram comparadas aos valores sugeridos pelas recomendações das normas brasileira, americana e européia, que se mostraram inadequadas para estimar a abertura de fissuras em concretos reforçados com fibras.

  9. Dystrophin analysis in carriers of Duchenne and Becker muscular dystrophy

    NARCIS (Netherlands)

    Hoogerwaard, Edo M.; Ginjaar, Ieke B.; Bakker, Egbert; de Visser, Marianne

    2005-01-01

    Associations between clinical phenotype (muscle weakness, dilated cardiomyopathy) and dystrophin abnormalities in muscle tissue among definite carriers of Duchenne (DMD) and Becker muscular dystrophy (BMD) were investigated. No associations between dystrophin abnormalities and clinical variables in

  10. Experimental investigation of muscular neurotization in the rat.

    Science.gov (United States)

    Must, R

    1987-01-01

    Reinnervation of a free muscle graft by nerves from an adjacent intact muscle is called muscular neurotization. This paper investigates the mechanisms and stimuli responsible for muscular neurotization in the rat. Sternohyoid or sternomastoid muscles were transplanted as free muscle grafts to the ventral surface of an intact sternohyoid muscle (feeder muscle). After several weeks the graft and underlying feeder muscle were removed together, frozen, serially sectioned, stained, and carefully examined for the presence or absence of nerves. It was concluded from a series of experiments that in this model muscular neurotization is a form of nerve regeneration. In order for muscular neurotization to occur, it is necessary to have (1) injury to the nerves of the intact feeder muscle and (2) a pathway upon which the regenerating nerves may grow into the graft.

  11. A new chart for weight control in Duchenne muscular dystrophy.

    OpenAIRE

    Griffiths, R D; Edwards, R H

    1988-01-01

    Weight control is desirable in the muscle wasting conditions. A new chart is presented to allow the prediction of an ideal weight, free of excess fat, specifically for boys with Duchenne muscular dystrophy.

  12. Nonmuscular involvement in merosin-negative congenital muscular dystrophy.

    NARCIS (Netherlands)

    Gilhuis, H.J.; Donkelaar, H.J. ten; Tanke, R.B.; Vingerhoets, D.M.; Zwarts, M.J.; Verrips, A.; Gabreëls, F.J.M.

    2002-01-01

    The spectrum of nonmuscular involvement in six children with merosin-negative congenital muscular dystrophy is described. In all children, biochemical, neuroradiologic, cardiac, and neurophysiologic studies were performed. Cerebral structures that were myelinated at gestation, including internal

  13. How Physicians Support Mothers of Children with Duchenne Muscular Dystrophy.

    Science.gov (United States)

    Fujino, Haruo; Saito, Toshio; Matsumura, Tsuyoshi; Shibata, Saki; Iwata, Yuko; Fujimura, Harutoshi; Shinno, Susumu; Imura, Osamu

    2015-09-01

    Communicating about Duchenne muscular dystrophy and its prognosis can be difficult for affected children and their family. We focused on how physicians provide support to the mothers of children with Duchenne muscular dystrophy who have difficulty communicating about the condition with their child. The eligible participants were certified child neurologists of the Japanese Society of Child Neurology. Participants responded to questionnaires consisting of free descriptions of a vignette of a child with Duchenne muscular dystrophy and a mother. We analyzed 263 responses of the participants. We found 4 themes on advising mothers, involving encouraging communication, family autonomy, supporting family, and considering the child's concerns. These results provide a better understanding of the communication between physicians and family members who need help sharing information with a child with Duchenne muscular dystrophy. These findings will assist clinical practitioners in supporting families and the affected children throughout the course of their illness. © The Author(s) 2015.

  14. Predictive factors for masticatory performance in Duchenne muscular dystrophy

    NARCIS (Netherlands)

    Bruggen, H.W. van; Engel-Hoek, L. van den; Steenks, M.H.; Bronkhorst, E.M.; Creugers, N.H.; Groot, I.J.M. de; Kalaykova, S.

    2014-01-01

    Patients with Duchenne muscular dystrophy (DMD) report masticatory and swallowing problems. Such problems may cause complications such as choking, and feeling of food sticking in the throat. We investigated whether masticatory performance in DMD is objectively impaired, and explored predictive

  15. Strength training and albuterol in facioscapulohumeral muscular dystrophy

    NARCIS (Netherlands)

    van der Kooi, EL; Vogels, OJM; van Asseldonk, RJGP; Lindeman, E; Hendriks, JCM; Wohlgemuth, M; van der Maarel, SM; Padberg, GW

    2004-01-01

    Background: In animals and healthy volunteers beta2-adrenergic agonists increase muscle strength and mass, in particular when combined with strength training. In patients with facioscapulohumeral muscular dystrophy (FSHD) albuterol may exert anabolic effects. The authors evaluated the effect of

  16. Modificação da rugosidade de fibras de carbono por método químico para aplicação em compósitos poliméricos

    Directory of Open Access Journals (Sweden)

    Burakowski Liliana

    2001-01-01

    Full Text Available O presente trabalho aborda o tratamento superficial de fibras de carbono por ácidos clorídrico e nítrico, visando o aumento controlado da rugosidade superficial da fibra e assim melhorar a ligação fibra/matriz no processamento de compósitos poliméricos reforçados com fibras longas. Foram utilizadas fibras de carbono com size, da empresa Toray. Essas foram tratadas com os ácidos clorídrico e nítrico, a 103°C, em concentrações de 35,5 % e 97 %, em massa, respectivamente, em tempos de exposição de 5, 10, 20, 30, 40 e 60 minutos. As fibras modificadas quimicamente foram caracterizadas por microscopia eletrônica de varredura e por ensaios mecânicos de tração e os dados foram tratados pelo método estatístico de Weibull. Os resultados mostram que os tratamentos empregados modificam a superfície da fibra e que períodos de tratamento superiores a 20 minutos as danificam, degradando de maneira significativa as suas propriedades mecânicas.

  17. Degradabilidad in situ de la materia seca, proteína y fibra del forraje de morera (morus alba

    Directory of Open Access Journals (Sweden)

    Carlos Boschini

    2001-01-01

    Full Text Available Con el propósito de conocer la degradabilidad ruminal de la materia seca, de la proteína cruda, de la fibra neutro detergente y de sus fracciones contenidas en rebrotes de morera de 56, 84 y 112 días. Se determinó la degradación en hojas, tallos y la planta entera. La degradabilidad potencial en los tres componentes estudiados fue disminuyendo conforme aumentó la edad del rebrote. La fracción soluble en la materia seca varió de 29 a 25% en la hoja y de 27 a 19% en el tallo al aumentar la edad de 56 a 112 días. La fracción degradable en la hoja se mantuvo constante en las tres edades (61-63% con tasas de degradación ruminal de 14, 10 y 9%/h a 56, 84 y 112 días. En el tallo la fracción degradable disminuyó de 42 a 30% entre 56 y 112 días con velocidades de degradación de 8,4, 6,7 y 5,3%/h al aumentar la edad. La proteína cruda soluble disminuyó de 41 a 33% en la planta entera, conforme aumentó la edad, y la fracción degradable permaneció constante en 49-51%. La tasa de degradación fue superior a 9,4%/h. La fibra neutro detergente presentó una fracción degradable de 71%, 62% y 43% a 56, 84 y 112 días respectivamente, con tasas de degradación de 13, 10 y 9%/h en el mismo orden. La degradación de la fibra neutro detergente se inició en el rumen con un tiempo de rezago de 1,5 a 3,2 horas

  18. DESENVOLVIMENTO DE PRODUTO À BASE DE FIBRAS DE BETERRABA (BETA VULGARIS VARIEDADE AÇUCAREIRA

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    CLáUDIA HELENA DEGÁSPARI

    2009-07-01

    Full Text Available

    O presente trabalho procurou desenvolver um produto para atender os indivíduos com doença celíaca. O produto escolhido foi uma formulação de quibe na forma frita. Os testes foram realizados comparando-se uma formulação de quibe contendo trigo integral moído com uma formulação que substituá 100% do trigo por fibra de beterraba (Fibrex® As formulações foram desenvolvidas apenas em protótipo de produto para demonstrar a aplicabilidade deste, submetendo-as a testes de análise sensorial de preferência com emprego do método de escala hedônica, com uma equipe de vinte provadores semitreinados. Os diversos testes sensoriais realizados demonstraram que tanto a formulação com trigo integral quanto a com fibra de beterraba mostraram-se sensorialmente adequadas, sem diferenças entre si nos parâmetros sensoriais avaliados, exceto no atributo aroma em que o resultado apontou uma diferença significativa de 5% em favor da formulação com fibra de beterraba. Pelos resultados de aceitabilidade, acredita-se ter esse produto um bom potencial de comercialização, principalmente para o público portador de doença celíaca. Da mesma forma, os cálculos de estimativa realizados para verificar o possível aumento no custo final do produto demonstraram que este não interfere significativamente, uma vez que o ingrediente que se apresenta com maior contribuição no custo final é a carne.

  19. Distrofia muscular progressiva: alguns aspectos do diagnõstico diferencial

    Directory of Open Access Journals (Sweden)

    Sylvio Saraiva

    1960-09-01

    Full Text Available The authors call attention to some clinical entities which are less known and more difficult to recognize and with which differential diagnosis of progressive muscular dystrophy should be made (infantile spinal muscular atrophy, amyotonia congenita, congenital acute anterior poliomyelitis, anthro-griposis multiplex, von Gierke's disease, central core disease, chronical polymyositis and dermatomyositis, thyrotoxic myopathy and menopausal dys- trophy. The importance of muscle biopsy in the differential diagnosis is emphasized.

  20. Pulmonary Endpoints in Duchenne Muscular Dystrophy. A Workshop Summary.

    Science.gov (United States)

    Finder, Jonathan; Mayer, Oscar Henry; Sheehan, Daniel; Sawnani, Hemant; Abresch, R Ted; Benditt, Joshua; Birnkrant, David J; Duong, Tina; Henricson, Erik; Kinnett, Kathi; McDonald, Craig M; Connolly, Anne M

    2017-08-15

    Development of novel therapeutics for treatment of Duchenne muscular dystrophy (DMD) has led to clinical trials that include pulmonary endpoints that allow assessment of respiratory muscle status, especially in nonambulatory subjects. Parent Project Muscular Dystrophy (PPMD) convened a workshop in Bethesda, Maryland, on April 14 and 15, 2016, to summarize published respiratory data in DMD and give guidance to clinical researchers assessing the effect of interventions on pulmonary outcomes in DMD.