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Sample records for fase aguda fa

  1. Meningoencefalite na fase aguda do sarampo : relato de seis casos

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    EL-FAR FABIANE

    2000-01-01

    Full Text Available Apresentamos 6 casos de meningoencefalite aguda por sarampo, diagnosticados durante epidemia na cidade de São Paulo, em 1997. Os prontuários dos 6 pacientes foram analisados retrospectivamente. O diagnóstico de meningoencefalite baseou-se nas alterações clínicas e liquóricas, e foi confirmado por sorologia específica. Dos 467 pacientes com sarampo atendidos no Instituto de Infectologia Emílio Ribas nesse período, estes 6 evoluíram com alterações neurológicas e liquóricas durante a fase exantemática, sendo a sonolência e rigidez de nuca os achados mais frequentes. Os pacientes tinham entre 2 meses e 28 anos de idade. O exame do líquor mostrou pleocitose em todos. Não houve correlação entre a severidade do quadro clínico e liquórico com a evolução. Em 4 casos foi necessária internação na unidade de terapia intensiva; destes, 2 foram intubados. Apenas 2 pacientes apresentaram alterações na tomografia computadorizada de crânio. Todos tiveram boa evolução, sem sequelas.

  2. Primeiro consenso brasileiro do tratamento da fase aguda do acidente vascular cerebral

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    2001-01-01

    Full Text Available Este texto apresenta a síntese das conclusões do Iº Consenso Brasileiro do Tratamento da Fase Aguda do Acidente Vascular Cerebral (AVC. Tratou-se de reunião patrocinada e coordenada pela Sociedade Brasileira de Doenças Cerebrovasculares, com neurologistas especializados nas doenças cerebrovasculares, que analisaram os principais itens da conduta dos AVC.

  3. Necessidades básicas das esposas de pacientes infartados na fase aguda do tratamento

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    Edna Ikumi Umebayashi Takahashi

    1990-12-01

    Full Text Available Trata-se de um estudo exploratório que teve por finalidade as necessidades básicas das esposas de pacientes infartados, na fase aguda do tratamento. Foi utlizado como referencial para análise os conceitos de Nacessidades Básicas de MASLOW. Os resultados permitiram identificar como principais necessidades afetadas das esposas: segurança, amor e gregária, estima.

  4. NECESSIDADES BÁSICAS DAS ESPOSAS DE PACIENTES INFARTADOS, NA FASE AGUDA DO TRATAMENTO

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    Edna Ikumi Umebayashi Takahashi

    Full Text Available Trata-se de um estudo exploratório que teve por finalidade identificar as necessidades básicas das esposas de pacientes infartados, na fase aguda do tratamento. Foi utilizado como referencial para análise os conceitos de Necessidades Básicas de Maslow. Os resultados permitiram identificar como principais necessidades afetadas das esposas: segurança, amor e gregária, estima.

  5. Necessidades básicas das esposas de pacientes infartados na fase aguda do tratamento

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    Edna Ikumi Umebayashi Takahashi

    Full Text Available Trata-se de um estudo exploratório que teve por finalidade as necessidades básicas das esposas de pacientes infartados, na fase aguda do tratamento. Foi utlizado como referencial para análise os conceitos de Nacessidades Básicas de MASLOW. Os resultados permitiram identificar como principais necessidades afetadas das esposas: segurança, amor e gregária, estima.

  6. Estudo longitudinal do eletrocardiograma na doença de Chagas desde a fase aguda

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    Roberto C. Pedrosa

    1993-09-01

    Full Text Available Vários trabalhos com eletrocardiograma na doença de Chagas têm sido feitos. Alguns referindo-se a grupos selecionados de casos, outros a estudos longitudinais, relatam as características da mortalidade nas diversas fases da doença. Com o objetivo de avaliar o valor do eletrocardiograma como índice de avaliação terapêutica e de seu comportamento na doença de Chagas desde a fase aguda, no presente trabalho, analisou-se evolutivamente o eletrocardiograma de 42 pacientes (18 mulheres e 24 homens procedentes da zona rural do Norte de Minas Gerais; predomínio etário foi nas duas primeiras décadas; todos com comprometimento cardíaco; todos receberam tratamento específico. O acompanhamento dos 42 pacientes foi de 9 anos dos quais 3 pacientes tiveram seguimento de 20 anos. Foram analisados 270 eletrocardiogramas. Nós utilizamos os seguintes critérios para a análise do ECG: código de Minnesota modificado para doença de Chagas; WHO/I. S. F. C. TASK FORCE para condução intraventricular e critérios de Pieretti para área eletricamente inativa. Concluímos que as alterações eletrocardiográficas agravam com a evolução da doença e que o eletrocardiograma não serve de índice de avaliação terapêutica.

  7. Estudo longitudinal do eletrocardiograma na doença de Chagas desde a fase aguda

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    Roberto C. Pedrosa

    1993-09-01

    Full Text Available Vários trabalhos com eletrocardiograma na doença de Chagas têm sido feitos. Alguns referindo-se a grupos selecionados de casos, outros a estudos longitudinais, relatam as características da mortalidade nas diversas fases da doença. Com o objetivo de avaliar o valor do eletrocardiograma como índice de avaliação terapêutica e de seu comportamento na doença de Chagas desde a fase aguda, no presente trabalho, analisou-se evolutivamente o eletrocardiograma de 42 pacientes (18 mulheres e 24 homens procedentes da zona rural do Norte de Minas Gerais; predomínio etário foi nas duas primeiras décadas; todos com comprometimento cardíaco; todos receberam tratamento específico. O acompanhamento dos 42 pacientes foi de 9 anos dos quais 3 pacientes tiveram seguimento de 20 anos. Foram analisados 270 eletrocardiogramas. Nós utilizamos os seguintes critérios para a análise do ECG: código de Minnesota modificado para doença de Chagas; WHO/I. S. F. C. TASK FORCE para condução intraventricular e critérios de Pieretti para área eletricamente inativa. Concluímos que as alterações eletrocardiográficas agravam com a evolução da doença e que o eletrocardiograma não serve de índice de avaliação terapêutica.Several studies have been done to analyse the relationship between the characteristics of the electrocardiogram (ECG and mortality in the several stages of the disease, using different methods like multiple case and longitudinal studies. We anatysed the ECGfrom the acute stage up to twenty years of follow-up (±9 years in 42 patients with Chagas ' disease to determine their evolution and it 's value like an indexfor therapeutic evaluation. The 42 patients (18 female, 24 males were originalty from the North of the State of Minas Gerais (Brazil and the initial stage was mainly in the first two decades of age. All bad cardiac involvementand received fiill specific treatment. We utilized the following criteria for the ECG analyses

  8. Leucograma e proteínas de fase aguda de ruminantes domésticos sadios e enfermos

    OpenAIRE

    Simplicio, Kalina Maria de Medeiros Gomes [UNESP

    2011-01-01

    Foi avaliada a importância de proteínas de fase aguda (PFA) como biomarcadores de enfermidades em ruminantes domésticos. Para tal se determinou o proteinograma sérico e leucograma de 15 bovinos sadios e 15 doentes, 15 ovinos sadios e 15 doentes, e 15 caprinos sadios e 15 doentes. Todos foram submetidos a colheitas diárias de sangue durante sete dias, enquanto permaneciam internados no Hospital Veterinário da FCAV-UNESP, Câmpus de Jaboticabal. Em bovinos a haptoglobina teve destaque como bioma...

  9. FA

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — An Area Forecast (FA) is a forecast of Visual Flight Rules (VFR) clouds and weather conditions over an area as large as the size of several states.

  10. Hemograma e proteínas de fase aguda de bezerros sadios do nascimento aos 30 dias de idade

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    Thaís G. Rocha

    2013-12-01

    Full Text Available O conhecimento da dinâmica das alterações nos parâmetros hematológicos e na cinética das proteínas de fase aguda em animais saudáveis nas primeiras semanas de vida é essencial para a interpretação correta dessas avaliações em situações de morbidez e para diferenciar animais sadios e enfermos de forma confiável. Com o intuito de avaliar a cinética desses parâmetros no primeiro mês de vida de bezerros de corte sadios, filhos de vacas primíparas ou pluríparas, amostras de sangue foram coletadas antes da ingestão de colostro e 1, 2, 7, 15 e 30 dias após o nascimento. Os parâmetros eritrocitários foram influenciados pelo número de partos das vacas e o leucograma mostrou alterações características de influência do cortisol fetal liberado por ocasião do nascimento. O teor sérico de proteína total aumentou significativamente após a ingestão do colostro. As concentrações de ceruloplasmina, haptoglobina e proteínas de pesos moleculares 33 kDa e 23 kDa aumentaram significativamente no primeiro dia de vida, seja pela resposta ao nascimento ou pela ingestão do colostro, enquanto os teores de transferrina, albumina e α1-glicoproteína ácida mantiveram-se relativamente estáveis nos primeiros dias de vida, aumentando gradualmente até os 30 dias de idade.

  11. Proteinograma sérico, com ênfase em proteínas de fase aguda, de bovinos sadios e bovinos portadores de enfermidade aguda de ocorrência natural

    OpenAIRE

    Simplício,K.M.M.G.; Sousa,F.C.; Fagliari,J.J.; Silva,P.C.

    2013-01-01

    Nas últimas décadas, as proteínas de fase aguda (PFAs) tornaram-se biomarcadores de escolha em medicina humana para identificação e monitoração de doenças. Não há razão para imaginar que tais pesquisas clínicas não sejam igualmente úteis na medicina veterinária. Com o objetivo de verificar a importância das PFAs como biomarcadores de doenças inflamatórias em bovinos, determinou-se o proteinograma sérico, por meio da técnica de eletroforese SDS-PAGE, com interesse especial nas PFAs. Foram util...

  12. Estudo imunobiológico de estoques de Trypanosoma cruzi isolados de pacientes na fase aguda da doença de Chagas

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    T.L. Kipnis

    1983-12-01

    Full Text Available Estoques de tripanossomas isolados de pacientes na fase aguda da doença de Chagas foram injetados em grupos de camundongos albinos não isogênicos nas doses de 10³, 10(4 e 10(5 parasitas/camundongos. O curso da infecção foi seguido por três meses. A pctrasitemia foi em geral baixa, com picos recorrentes, na maioria das vezes os animais evoluiam para cronicidade. Somente um estoque induziu alto índice de mortalidade. Os parasitas e as lesões apesar de detectadas no pico da parasitemia e restritos ao coração estavam ausentes aos três meses. Nesta época os perfis de Igs apresentaram diferenças marcantes. Grupos de animais que foram inoculados com estes estoques foram desafiados com doses letais da cepa Y ou CL. Em alguns casos obteve-se uma parasitemia, mas patente.

  13. Resposta de fase aguda e níveis séricos de magnésio em pacientes hospitalizados

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    Cunha,D. F. da; Bianco,M. de P.; Lenza,R. da M.; Cunha,S. F. de C. da

    1999-01-01

    OBJETIVO: A resposta de fase aguda (RFA), caracteriza-se por proteólise, com hipotrofia da massa celular corporal, hiperglicemia, retenção hídrica e disfunção renal, fenômenos que potencialmente afetam os níveis de magnésio (Mg++) sérico. O objetivo do estudo foi comparar os níveis séricos de Mg++ entre pacientes hospitalizados, com ou sem RFA. MÉTODOS: Obteve-se um banco de dados do mainframe do Hospital-Escola contendo informações sobre dosagens bioquímicas simultâneas de creatinina, glicos...

  14. Prioridades de intervención para la fase aguda de las emergencias complejas formuladas por nueve agencias de ayuda humanitaria

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    Carmen Sofía Carrillo Jaimes

    2004-01-01

    Full Text Available Las Emergencias Complejas son un problema de Salud Pública internacional de frecuencia y magnitud crecientes que producen una importante mortalidad y morbilidad especialmente durante su fase aguda. El objetivo de este estudio es identificar y analizar las áreas prioritarias de intervención en la fase aguda de una emergencia compleja formuladas en los manuales operativos de las principales agencias de ayuda, así como el nivel de desarrollo y estructuración de las actividades propuestas en cada área de prioridad. Métodos: Como material de estudio se utilizaron los manuales de intervención elaborados por 9 de las principales agencias de ayuda. Se procedió a un análisis cuantitativo de las 16 prioridades de intervención planteadas así como del nivel de formulación de cada prioridad en base al desarrollo de 73 variables o aspectos de las propuestas formuladas en los manuales. Resultados: El manual de ACNUR recoge el 90% de las 73 variables de desarrollo de las prioridades y el de Oficina de Coordinación de Asuntos Humanitarios de Naciones Unidas el 35% de las 73 variables. ACNUR presenta el mejor desarrollo de las variables no sanitarias, seguido de MSF y USAID. Médicos sin fronteras muestra un grado de desarrollo de las variables sanitarias del 97,3% seguido de ACNUR (94,7%, USAID y UNICEF (92,1%. Conclusiones: Se ha encontrado que ACNUR tiene la propuesta más integral y Oficina de Coordinación de Asuntos Humanitarios de Naciones Unidas la más discreta. Existe una tendencia general a desarrollar y unificar los indicadores de salud, mientras que otros aspectos no se desarrollan.

  15. Cinesioterapia previne ombro doloroso em pacientes hemiplégicos/paréticos na fase sub-aguda do acidente vascular encefálico

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    Horn Agnes Irna

    2003-01-01

    Full Text Available CONTEXTO: Ombro doloroso é freqüente em pacientes com hemiplegia/hemiparesia (H/P por acidente vascular encefálico (AVE, dificultando a recuperação neuromotora gerando incapacidade funcional. OBJETIVO: Estudar tratamento fisioterapêutico para a prevenção da dor no ombro com H/P em pacientes com AVE na fase sub-aguda, e analisar desfechos secundários (força muscular do ombro acometido e movimentos funcionais ativos básicos. MÉTODO: Estudaram-se 21 pacientes (12 homens, 9 mulheres; idades 26 a 87 anos com H/P. O tratamento fisioterapêutico consistiu de 30 minutos diários de cinesioterapia, desde as 48 horas após o AVE até a alta hospitalar. Os pacientes foram avaliados antes e após o tratamento em relação à presença ou ausência de dor no ombro H/P, à força dos diversos grupos musculares do ombro e quanto aos movimentos funcionais de transferência e manutenção postural básica. RESULTADOS: Nenhum paciente apresentava dor no ombro H/P na alta (p<0,001. A força muscular aumentou significativamente em relação à elevação, protusão, abdução e flexão do ombro (p<0,001. Houve melhora dos movimentos funcionais: decúbito dorsal para lateral, decúbito lateral para sentado e manter-se sentado (p<0,001. CONCLUSÃO: A cinesioterapia na fase aguda do AVE preveniu a dor no ombro H/P e favoreceu a recuperação motora.

  16. Malondialdehyde in early phase of acute pancreatitis Malondialdehído en la fase inicial de la pancreatitis aguda

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    Vicent Hernández

    2011-11-01

    Full Text Available Aims: to assess oxidative stress in acute pancreatitis, its evolution over time and its relationship with the severity of the disease. Methods: during a two-year period, patients with acute pancreatitis with less than 24 hours of pain were evaluated. Serum was obtained the first, second and fourth day from admittance, if complications were detected, and after recovery. Malondialdehyde was determined by high performance liquid chromatography. Twenty healthy volunteers constituted the control group. Malondialdehyde between groups was compared with Mann-Whitney and Kruskal-Wallis tests; malondialdehyde evolution was studied with Wilcoxon test. Results: one hundred and sixty-nine patients were included (91 women, median age 67 years, range 20-95; 33 suffered a severe episode. Malondialdehyde decreased from first to fourth day (0.600 vs. 0.451 vs. 0.343 μM, respectively, p 0.05. In severe attacks malondialdehyde was higher than in control group at day 2 (severe: 0.514; mild: 0.440; control: 0.347 μM, p Objetivos: valorar el estrés oxidativo en la pancreatitis aguda, su evolución a lo largo del tiempo y su relación con la gravedad de la enfermedad. Métodos: durante un periodo de dos años, se estudiaron los pacientes ingresados por pancreatitis aguda con dolor abdominal de menos de 24 horas de evolución. Se obtuvo suero de los pacientes el primer, segundo y cuarto día de ingreso, en el momento en que se detectaban complicaciones y tras la recuperación. La concentración de malondialdehído fue determinada utilizando cromatografía líquida de alta resolución. Veinte voluntarios sanos conformaron el grupo control. La concentración de malondialdehído entre los diferentes grupos se comparó utilizando el test de Mann-Whitney y el test de Kruskal-Wallis; la evolución de malondialdehído se valoró mediante el test de Wilcoxon. Resultados: se incluyeron 169 pacientes (91 mujeres, edad mediana 67 años, rango 20-95; 33 sufrieron un episodio

  17. Histopatologia da esquistossomose mansoni em fígado de Mus musculus infectado por amostras humanas de fase aguda e crônica da periferia de Belo Horizonte, Minas Gerais

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    Amélia Dulce Vilela de Carvalho

    1986-06-01

    Full Text Available Exemplares de Biomphalaria glabrataforam infectados com miracídios obtidos de ovos de Schistosoma mansoni, encontrados em fezes de indivíduos de 7 a 18 anos, da região de Lagoa da Pampulha, Belo Horizonte, MG. Os pacientes de fase aguda se infectaram em uma primeira visita ao foco. Os da fase crônica eram moradores próximos aos focos. Para cada caso clínico, isolou-se a respectiva amostra do parasita. Foram infectados pela cauda 55 camundongos fêmeas com 70 ± 10 cercárias. Cortes histológicos de fígados, corados por HE, tricrômico de Gomori, impregnação metálica pela prata, e PAS foram observados à microscopia óptica. Não houve diferenças estatísticas em relação às médias das mensurações dos diâmetros dos granulomas referentes às amostras e datas de sacrifícios. Os granulomas apresentaram fase exsudativa do tipo Ha (reação de inflamação mista e IIIa (granuloma com células epitelióides. Com amostras de pacientes em fase aguda o padrão predominante foi a Ha na 7ª semana. Na 10.ª semana predominaram granulomas do tipo IIIa. Nas amostras de pacientes em fase crônica, verificou-se uma mescla de granulomas do tipo Ha e IIIa na 7ª semana. Na 10ª semana predominou o tipo IIIa. Alguns aspectos histopatológicos de fígados foram descritos e comparados com aqueles existentes na literatura.

  18. Proteinograma sérico, com ênfase em proteínas de fase aguda, de bovinos sadios e bovinos portadores de enfermidade aguda de ocorrência natural

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    K.M.M.G. Simplício

    2013-10-01

    Full Text Available Nas últimas décadas, as proteínas de fase aguda (PFAs tornaram-se biomarcadores de escolha em medicina humana para identificação e monitoração de doenças. Não há razão para imaginar que tais pesquisas clínicas não sejam igualmente úteis na medicina veterinária. Com o objetivo de verificar a importância das PFAs como biomarcadores de doenças inflamatórias em bovinos, determinou-se o proteinograma sérico, por meio da técnica de eletroforese SDS-PAGE, com interesse especial nas PFAs. Foram utilizados 30 animais, distribuídos em dois grupos: 15 bovinos sadios e 15 bovinos doentes (cinco com mastite estafilocócica, cinco com fotossensibilização e cinco com onfaloflebite. Os animais foram submetidos a colheitas diárias de sangue durante sete dias, enquanto internados no Hospital Veterinário da Unesp, Campus de Jaboticabal. Ceruloplasmina e haptoglobina apresentaram elevação significativa em animais acometidos por mastite, fotossensibilização e onfaloflebite (275,17% e 343,71%; 175,17% e 230,19%; 114,47% e 144,47%, respectivamente. A α1-glicoproteína ácida foi um bom biomarcador apenas em animais com mastite e fotossensibilização, elevando, respectivamente, suas concentrações séricas em 198,14% e 145,89%. Fibrinogênio mostrou-se um indicador confiável apenas em bovinos com mastite, com elevação de 146,5% em relação ao grupo sadio. Ficou clara a diferença na responsividade de distintas PFAs frente a diferentes estímulos inflamatórios. Ceruloplasmina e haptoglobina foram biomarcadores mais sensíveis e, portanto, mais confiáveis entre as PFAs estudadas nessa espécie.

  19. Características clínicas da fase aguda da infecção experimental de felinos pelo vírus da imunodeficiência felina

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    M.S. Zanutto

    2011-03-01

    Full Text Available A infecção dos felinos pelo Vírus da Imunodeficiência Felina (FIV resulta no desenvolvimento da síndrome de imunodeficiência dos felinos. Gengivite, perda de peso, linfadenomegalia generalizada, anemia, insuficiência renal crônica, complicações neurológicas, diarréia crônica e infecções bacterianas são encontradas frequentemente. A fase aguda da infecção pode ser assintomática, retardando o estabelecimento do diagnóstico e a implantação de medidas profiláticas para restringir o contágio e a transmissão do agente aos felinos suscetíveis. Com a finalidade de estudar as características clínicas da fase aguda da infecção, dez felinos jovens, sem definição racial, com oito meses de idade foram inoculados por via endovenosa com 1mL de sangue venoso de um gato portador do FIV subtipo B. A confirmação da infecção foi obtida através de teste sorológico em quatro e oito semanas pós-inoculação (p.i. e por nested-PCR. Foram realizados hemogramas semanais, exame ultrassonográfico do abdômen quinzenais e exame oftalmológico mensal, durante doze semanas p.i. Discreta tendência a linfopenia na segunda semana p.i. e a neutropenia entre a quinta e sétima semana p.i., febre intermitente em alguns gatos, linfadenomegalia e hepato-esplenomegalia entre a quarta e a 12ª semana p.i. foram as alterações clínicas observadas. Apenas um gato apresentou uveíte unilateral direita. A fase aguda da infecção transcorreu com alterações clínicas inespecíficas. A linfadenomegalia e a hepato-esplenomegalia observadas no decorrer da infecção, refletindo hiperplasia linfóide, sugerem a necessidade de se realizar o teste sorológico para o FIV, em todos os gatos que se apresentarem com essas alterações, o que permitirá o diagnóstico precoce da infecção e a adoção de medidas profiláticas no sentido de minimizar a propagação da infecção.

  20. Reação de fase aguda e sua relação com o desempenho de cavalos em competição de longa distância

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    L.A. Amaral

    2015-04-01

    Full Text Available O exercício físico é um dos estímulos fisiológicos mais estressantes que um animal pode sofrer e, dependendo de sua intensidade, sugere-se que possa gerar uma reação mediada por proteínas de fase aguda (PFA. O objetivo deste estudo foi caracterizar a reação de fase aguda e sua relação com o desempenho de cavalos submetidos a uma competição de longa distância. O experimento foi desenvolvido durante a Marcha de Resistência anual promovida pela Associação Brasileira de Criadores de Cavalos Crioulos (ABCCC, composta por um percurso de 750km percorrido durante 15 dias. Foram avaliados 23 equinos, os quais foram divididos em dois grupos, sendo o grupo 1 composto pelos 10 primeiros colocados na competição e o grupo 2 formado pelos 13 animais que concluíram a competição em colocações inferiores ou foram desclassificados antes de terminar a prova. Efetuaram-se coletas sanguíneas em repouso (dia 0 e no último dia de competição, e foi realizado o teste de eletroforese em gel de poliacrilamida contendo dodecil sulfato de sódio (SDS-PAGE para identificar as proteínas (albumina, haptoglobina, ceruloplasmina, transferrina, imunoglobulina G, imunoglobulina A, glicoproteína ácida e proteína de peso molecular de 23kDa. Os resultados demonstraram que o exercício físico imposto influenciou de forma significativa (P<0,0001 as concentrações séricas de haptoglobina, ceruloplasmina, imunoglobulina A, glicoproteína ácida e proteína de peso molecular de 23kDa. Quando comparados os resultados dos grupos estudados, observou-se que a concentração de haptoglobina após a competição foi superior no grupo de animais com baixo desempenho (grupo 2. Conclui-se que a competição de longa duração é capaz de gerar reação de fase aguda e que o monitoramento da concentração de haptoglobina pode ser um sinalizador de processo inflamatório e baixo desempenho.

  1. Ação do prebiótico sobre as proteínas de fase aguda de pacientes com neoplasia hematológica Action of prebiotics on proteins in the acute phase of hematologic neoplasia

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    Telma Búrigo

    2007-06-01

    Full Text Available Os pacientes com neoplasias hematológicas são submetidos a tratamento quimioterápico que induz uma intensa alteração na integridade da mucosa intestinal, favorecendo um aumento da sua morbi-mortalidade. O presente trabalho foi desenvolvido na Unidade de Transplante de Medula Óssea do Centro de Pesquisas Oncológicas em Florianópolis - SC e teve como objetivo estudar a ação do prebiótico na resposta de proteína da fase aguda de pacientes com neoplasias hematológicas submetidos à quimioterapia. Foi realizado um estudo clínico randomizado duplo cego envolvendo 25 pacientes divididos em dois grupos que receberam por 15 dias: 12g de FOS (n=14 ou placebo (maltodextrina (n=11. Todas as variáveis foram determinadas antes e após a suplementação. Foram avaliados os níveis séricos das proteínas de fase aguda negativas (albumina e pré-albumina e a proteína de fase aguda positiva, proteína C reativa (PCR. Verificaram-se a presença de diarréia e de constipação, bem como a quantidade de bifidobactérias e valores de pH fecal. A redução dos níveis séricos de proteínas de fase aguda negativas (albumina e pré-albumina comprovam o intenso catabolismo protéico, priorizando a síntese de proteína de fase aguda positiva (PCR. O grupo suplementado apresentou um aumento significante na quantidade de bifidobactérias e o pH fecal não foi alterado em ambos os grupos. Os níveis séricos de PCR foram estatisticamente superiores no grupo controle, indicando a ocorrência de processos inflamatórios e maior demanda metabólica, sugerindo que a quantidade de bifidobactérias pode ter favorecido a redução deste quadro no grupo suplementado, confirmado pela correlação negativa entre estas variáveis.Patients with hematologic neoplasias are submitted to chemotherapeutic treatment that induces intense alterations in the integrity of the intestinal mucous membrane, favoring an increase in the morbimortality rate. The current work was

  2. Manifestaciones clínicas y complicaciones de la fase aguda de bartonelosis o Fiebre de la Oroya en pacientes atendidos en el Hospital Nacional Cayetano Heredia.

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    Ciro Peregrino Maguiña Vargas

    2008-07-01

    Full Text Available Objetivos: Determinar las características clínicas, epidemiológicas y de laboratorio de la bartonelosis aguda, así como las complicaciones en una serie de pacientes atendidos en el Hospital Nacional Cayetano Heredia. Material y métodos: Estudio descriptivo de tipo serie de casos de pacientes mayores de 15 años con bartonelosis aguda hospitalizados en el Hospital Nacional Cayetano Heredia entre 1993 y 2006. Resultados: La edad promedio fue 27,8 años, 72,7% fueron varones, 51,5% procedía de Lima y 33,3% de Ancash. Los síntomas principales fueron: fiebre 90,9%, cefalea 87,9%, hiporexia 75,5%, baja de peso 63,6%, e ictericia 57,6%. Dos pacientes presentaron alteraciones en el fondo de ojo: retinitis exudativa y retinopatía hemorrágica. El hematocrito promedio fue 20,8% y 63,6% cursaron hematocrito £20%. Hubo desviación izquierda en 24,2%, hiperbilirrubinemia a predominio indirecto 62,5% e hipoalbuminemia (< 3mg/dl 56,5%. Se presentaron complicaciones en 84,8%, el 27,2% requirió internamiento en UCI. Las complicaciones no infecciosas ocurrieron en 84,8%, hematológicas 81,8% y gastrointestinales 78,7%. Las complicaciones infecciosas se presentaron en 12,1%. Los antibióticos más utilizados fueron ciprofloxacina 66,6% y cloranfenicol 42,4%, se administró corticoides en 9,1% y se transfundió paquete globular en 42,4%. Conclusiones: Los pacientes de UCI tuvieron más complicaciones cardiovasculares, trombocitopenia y mayor severidad de la anemia. No se registró mortalidad. (Rev. Med Hered 2008;19:87-95

  3. Hemometabolismo cerebral: variações na fase aguda do coma traumático Cerebral hemometabolism: variability in the acute phase of traumatic coma

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    ANTONIO L. E. FALCÃO

    2000-09-01

    Full Text Available OBJETIVO: avaliar as interrelações entre as alterações hemometabólicas cerebrais e sistêmicas em pacientes com traumatismo craniencefálico (TCE grave submetidos a um protocolo terapêutico padronizado. DESENHO: estudo prospectivo, intervencionista em pacientes com coma traumático. LOCAL: uma UTI geral em hospital universitário. PACIENTES E MÉTODOS: vinte e sete pacientes (21M e 6F, idade 14-58 anos, com TCE grave, com três a oito pontos na escala de coma de Glasgow, foram avaliados prospectivamente segundo um protocolo cumulativo padronizado para tratamento da hipertensão intracraniana aguda, o qual incluía medidas rotineiras da pressão intracraniana (PIC e da extração cerebral de oxigênio (ECO2. Foram analisadas as interrelações hemometabólicas envolvendo: pressão arterial média (PAM, PIC, pressão parcial de gás carbônico arterial (PaCO2, ECO2, pressão de perfusão cerebral (PPC e extração sistêmica de oxigênio (ESO2. INTERVENÇÕES: apenas as padronizadas no protocolo terapêutico. RESULTADOS: não houve correlação entre a ECO2 e a PPC (r = -0,07; p = 0,41. Houve correlação inversa entre a PaCO2 e a ECO2 (r = -0,24; p = 0,005 e direta entre a ESO2 e a ECO2 (r = 0,24; p = 0,01. A mortalidade geral dos pacientes foi de 25,9% (7/27. CONCLUSÃO: 1 a PPC não se correlaciona com a ECO2 em quaisquer níveis de PIC; 2 a ECO2 está estreitamente relacionada aos diferentes níveis de PaCO2 ; e 3 durante a hiperventilação otimizada existe um acoplamento entre a ECO2 e a ESO2.OBJECTIVE: to evaluate the interrelationships between cerebral and systemic hemometabolic alterations in patients with severe traumatic brain injury managed according to a standardized therapeutic protocol. DESIGN: prospective, interventional study in patients with traumatic coma. SETTING: a general Intensive Care Unit in a teaching hospital. PATIENTS AND METHODS: twenty-seven patients (21M e 6F, aging 14--58 years, with severe acute brain trauma

  4. Avaliação de provas de fase aguda em crianças e adolescentes com artrite idiopática juvenil e sua correlação com atividade da doença Acute phase reactants evaluation in children and adolescents with juvenile idiopathic arthritis and its correlation with disease activity

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    Aline Alencar M. F. Nicácio

    2009-06-01

    Full Text Available OBJETIVO:Analisar a relação entre as provas de fase aguda e a atividade clínica da artrite idiopática juvenil e avaliar a concordância entre velocidade de hemossedimentação e proteína C reativa (VHS e PCR na fase aguda da doença. MÉTODOS: Foi realizado estudo retrospectivo tipo coorte a partir da análise de prontuários de 30 crianças e adolescentes que preenchiam os critérios diagnósticos para artrite idiopática juvenil, estavam em atendimento em ambulatório de Reumatologia Pediátrica e haviam realizado as provas de fase aguda (VHS e PCR. RESULTADOS: Dos 30 pacientes, 21 (70% eram do sexo feminino e 19 (63,3% apresentavam o subtipo oligoarticular da doença. A média de idade de início dos sintomas foi 65,6 meses, a idade de diagnóstico de 85,3 e o tempo de evolução, 57,2 meses. As provas de fase aguda mostraram associação positiva com a atividade de doença. A anemia não teve relação com a atividade de doença. A concordância entre as duas provas de fase aguda foi superior a 80%. CONCLUSÕES: As provas de fase aguda mantêm relação positiva com a atividade da doença e o seu uso concomitante aumenta a especificidade.OBJECTIVE:To analyze the relationship between the acute phase reactants and the disease activity of Juvenile Idiopathic Arthritis (JIA and to evaluate the agreement between erythrocyte sedimentation rate and C-reactive protein during the acute phase of the disease. METHODS: a cohort retrospective study has been conducted based on the analysis of 30 children and adolescents who fulfilled the diagnostic criteria of JIA. All of them were in current follow-up at the pediatric rheumatology outpatient clinic and had acute phase reactants blood tests performed. RESULTS: Studied population comprised 30 patients: 21 (70% of them were females and 19 (63.3% presented oligoarticular subtype. The mean age at disease onset was 65.6 months; the age at diagnosis was 85.3 months and the follow-up had 57.2 months of

  5. Estudo parasitológico e anátomo-patológico da fase aguda da doença de Chagas em cães inoculados com duas diferentes cepas do Trypanosoma cruzi

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    Maria Alice Pedreira de Castro

    1985-12-01

    Full Text Available Cães jovens foram infectados com as cepas Y e CL do T. cruzi usando-se como inóculos 107 formas sangüíneas inoculadaspor via intraperitoneal e 2 x 10³ tripomastigotas metacíclicos obtidos do inseto vetor e inoculadospor via conjuntival. As cepas Ye CL induziram nos cães curvas deparasitemia totalmente distintas, confirmando dados parasitológicos obtidos em camundongos e coelhos. Com a cepa CL a parasitemia, com ambos os inóculos, foi gradualmente ascencional ao passo que com Y a parasitemia foi extremamente baixa, irregular e, com freqüência, subpatente. Com ambas as cepas o parasitismo e as lesões predominaram no miocárdio. Entretanto, com a cepa Y a miocardite foi sempre intensa desde as fases mais precoces da infecção, ao passo que com a cepa CL o processo inflamatório tomou-se acentuado somente a partir do 20.° dia. Freqüentemente a intensidade da miocardite observada em alguns animais não guardava relação com a parasitemia; em alguns cães com parasitemia subpatente, nos quais a infecção só foi diagnosticada pelo xenodiagnóstico, a intensidade da miocardite foi comparável àquela observada nos animais com parasitemia patente. Idêntica correlação também não foi assinalada em relação ao parasitismo tissular. Esses achados sugerem a participação de mecanismo imunológicos na gênese das lesões, ainda na fase aguda da infecção.Young dogs were inoculated with T. cruzi Y and CL strains either by intraperitoneal route with 107 blood forms or by ocular route with 2 x 10³ vector-derived trypomastigotes. With both inocula the patterns of parasitemia were significantly different, confirming data previously obtained in experimentally infected mice and rabbits. CL strain induced a gradual ascencional parasitemia whereas with Y the parasitemia was either subpatent or the number of parasites was very low, rapidly declining. Although myocarditis was present in most animals regardless of the strain used, the

  6. Tratamento cirúrgico da endocardite infecciosa na fase aguda: experiência de três anos Surgical treatment of infective endocarditis in the acute phase: a three-year experience

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    Iseu Affonso da Costa

    1987-08-01

    Full Text Available O tratamento cirúrgico da endocardite na fase aguda vem-se impondo como o mais efetivo, em muitas circunstâncias clínicas. As contínuas modificações nos aspectos clínicos, diagnósticos e bacteriológicos desta afecção tornam necessária permanente avaliação dos resultados, nas situações concretas de atuação dos diversos grupos clínico-cirúrgicos. A definição de normas de conduta ante esta grave afecção tem-nos preocupado, ultimamente, por sua crescente participação em nossa prática clínica-cirúrgica. De novembro de 1983 a novembro de 1986, 6,7% das substituições valvares por nosso grupo cirúrgico deveram-se a endocardite (32 de 4,77 pacientes. A sede do processo infeccioso teve a seguinte distribuição: mitral 6 casos, aórtica 12 casos (um óbito, mitral e aórtica 6 casos (dois óbitos prótese aórtica 4 casos (três óbitos, prótese mitral 2 casos (um óbito mitral, aórtica e tricúspide 1 caso (um óbito e parede do ventrículo esquerdo 1 caso. A idade variou entre 10 e 56 anos. Sete pacientes eram do sexo feminino e 24 do masculino. Todos os pacientes eram brancos. A análise dos achados anátomo-patológicos permitiu determinação de três grupos: no Grupo A, tivemos 11 operações por lesões valvares simples, consistentes basicamente de vegetações infectadas. Todos os pacientes sobreviveram e obtiveram alta hospitalar. Nos 15 pacientes do Grupo B, havia acometimento multivalvar, ou lesões complicadas por mutilações valvares extensas e/ou comunicações entre câmaras cardíacas; 5 pacientes faleceram. No Grupo C, houve 5 operações por infecções em próteses, ocorrendo 4 óbitos. O prognóstico favorável dos pacientes operados com lesões simples e o alto risco daqueles em que havia destruição tissular mais extensa e daqueles em que a endocardite se instalou em próteses, nos levam a defender o tratamento cirúrgico precoce das infecções valvares, em todos os casos em que não haja r

  7. Apendicitis Aguda

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    Jorge Fallas González

    2012-01-01

    La apendicitis aguda, descrita desde 1886, es la emergencia quirúrgica más común. Tiene su mayor incidencia durante la adultez joven y su menor incidencia en niños y adultos mayores. Su diagnóstico se basa en una historia clínica completa, un examen físico bien orientado y en una adecuada interpretación de los exámenes de laboratorio y gabinete. A pesar de ser una entidad de resolución quirúrgica, su tratamiento engloba diferentes aspectos médicosAcute appendicitis, described since 1886, is t...

  8. Acute phase proteins: a potential approach for diagnosing chronic infection by Trypanosoma vivax Proteínas de fase aguda: uma possível abordagem para diagnóstico de infecção crônica por Trypanosoma vivax

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    Katyane de Sousa Almeida

    2012-06-01

    Full Text Available The present study aimed to assess potential changes in acute phase proteins in sheep experimentally infected with Trypanosoma vivax. There were studied eight male sheep, four used as controls and four infected with 10(5 T. vivax trypomastigotes. Blood samples were collected at two points times before infection and then at 5,7, 9, 11, 13, 15, 20, 30, 45, 60, 75, 90, 105 and 120 days post-infection (dpi. Blood samples were centrifuged and allotted, and acute phase proteins were then separated by electrophoresis on acrylamide gel containing sodium dodecyl sulfate. Protein concentrations were determined by computer-assisted densitometry. Total protein was determined by colorimetric biuret method. Trypanosomes were counted daily using a 5 mL aliquot of blood smear on a glass slide under a 22 × 22 mm coverslip. Parasites were counted in 100 microscopic fields (40× magnification, and then multiplied by a correction factor. The results were expressed as parasites per mL of blood. For statistical analyses, we used the Wilcoxon test at 5% significance level. There was found a reduction in several acute phase proteins and increase in antitrypsin and transferrin. This finding can be used for the diagnosis of T. vivax infection, especially in chronic infection.O objetivo do presente estudo foi verificar possíveis alterações nas proteínas de fase aguda em ovinos infectados experimentalmente com Trypanosoma vivax. Para tanto, foram utilizados oito ovinos machos, sendo quatro usados como controle e quatro infectados com 10(5 tripomastigotas de T. vivax. Colheram-se amostras de sangue em dois tempos antes da infecção e, posteriormente, aos 5, 7, 9, 11, 13, 15, 20, 30, 45, 60, 75, 90, 105 e 120 dias após a infecção (dpi; após centrifugação e aliquotização das amostras. As proteínas de fase aguda foram separadas por eletroforese em gel de acrilamida, contendo dodecil sulfato de sódio, e suas concentrações foram determinadas através de

  9. Leucogram and serum acute phase protein concentrations in queens submitted to conventional or videolaparoscopic ovariectomy Leucograma e concentrações séricas de proteínas de fase aguda de gatas submetidas à ovariectomia convencional ou por videolaparoscopia

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    A.E. Alves

    2010-02-01

    Full Text Available Thirty health queens were submitted to ovariectomy by conventional technique or by videolaparoscopy. In order to study the intensity of inflammatory response by means of acute phase protein analysis and white blood cell count, serum samples were taken before and until 144 hours after the surgical procedures. The protein concentrations that were significantly increased 24 hours after surgical procedures were: ceruloplasmin, hemopexin, haptoglobin, and α1-acid glycoprotein, 69.8%, 103.5%, 117.3%, and 199.0%, respectively, for conventional ovariectomy; and 22.3%, 46.1%, 79.8%, and 74.6%, respectively, for laparoscopic ovariectomy. Therefore, inflammatory response was more intense in queens submitted to conventional ovariectomy. Results indicate that the increase or decrease in acute phase proteins, as well as in white blood cells count, may be useful in the evaluation of inflammatory response induced by these surgical procedures.Trinta gatas, saudáveis, foram submetidas à ovariectomia pela técnica convencional e por videolaparoscopia. Amostras de sangue foram obtidas com o objetivo de verificar a intensidade da resposta inflamatória por meio da análise das concentrações de proteinas de fase aguda e contagem de leucócitos antes e até 144 horas após procedimento cirúrgico. As proteínas que apresentaram aumento significativo 24 horas após a cirurgia foram: ceruloplasmina, hemopexina, haptoglobina e α1-glicoproteína ácida, 69,8%, 103,5%, 117,3% e 199,0%, respectivamente, para ovariectomia convencional, e 22,3%, 46,1%, 79,8% e 74,6%, respectivamente, para ovariectomia por videolaparoscopia. A resposta inflamatória foi mais evidente nas gatas submetidas à ovariectomia convencional. Os resultados mostram aumento e diminuição na concentração de proteínas de fase aguda e na contagem de leucócitos, podendo ser utilizados na avaliação da resposta inflamatória induzida por procedimentos cirúrgicos.

  10. Immunohistochemical expression of oestrogen and progesterone receptors during experimental acute and chronic murine Schistosomiasis mansoni Expressão imunohistoquímica de receptores para estrogênio e progesterona nas fases aguda e crônica da esquistossomose mansônica experimental em camundongos

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    Fawzia Ahmed Habib

    2010-10-01

    Full Text Available INTRODUCTION: The responsibility of Schistosoma mansoni in female infertility is still controversial. This study was conducted to evaluate the effect of acute and chronic schistosomiasis mansoni infection on the endometrium using immunohistochemical analysis of uterine hormone receptor expression. METHODS: Twenty-four nonpregnant swiss albino mice were divided into three groups: control, noninfected; acute; and chronic Schistosoma mansoni infection. Histological sections of uterine specimens were examined by light microscope with an image analyzing system to detect structural histological, estrogen receptor (ER and progesterone receptor (PR expression in the endometrium. RESULTS: No secretory phase was detected in the endometrium in acute and chronic Schistosoma infection. Hormone receptor expression (ER and PR showed statistically significant differences among the groups (pINTRODUÇÃO: A responsabilidade do Schistosoma mansoni em esterilidade feminina é ainda controversa. Este estudo é conduzido para avaliar o efeito da esquistossomose mansoni aguda e crônica no endométrio usando análise de imuno-histoquímíca da expressão de receptor hormonal uterina. MÉTODOS: Vinte e quatro camundongos fêmeas albinas suíças não grávidas foram divididas em 3 grupos (controle não-infectado, grupos agudos e crônicos infeccionados com Schistosoma mansoni. As seções histológicas de espécimes uterinos foram examinadas por microscópio leve com imagem, analisando sistema para detectar no endométrio expressões histológicas estruturais, receptor de estrogênio (ER e receptor de progesterona (PR. RESULTADOS: Nenhuma fase secretora foi detectada no endométrio com infecção aguda e crônica de Schistosoma. A expressão hormonal de receptor (ER e PR mostrou diferenças estatisticamente significantes entre grupos diferentes (p<0,05 com baixa significativa hormonal de ER com infecção crônica (comparado com controle proliferativo, controle secret

  11. Papel do óxido nítrico no desenvolvimento de lesões cardíacas na fase aguda da infecção experimental pelo Trypanosoma cruzi Role of nitric oxide in the development of cardiac lesions during the acute phase of experimental infection by Trypanosoma cruzi

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    Cláudia Renata Bibiano Borges

    2009-04-01

    Full Text Available A doença de Chagas é causada pelo Trypanosoma cruzi e o coração é o órgão mais acometido. O óxido nítrico apresenta importante ação anti-Trypanosoma, porém, com pouca evidência de seu papel no mecanismo de lesão tecidual. O objetivo deste estudo foi analisar a contribuição do óxido nítrico no desenvolvimento da inflamação e da fibrose cardíaca na fase aguda da infecção experimental por cepas Y e Colombiana do Trypanosoma cruzi. A inflamação foi significativamente maior nos animais infectados pela cepa Colombiana, comparada com os infectados com a cepa Y, tanto nos animais C57BL/6 (3,98x1,87%; p=0,004 quanto nos animais C57BL/6 deficientes na sintase do óxido nítrico induzível (3,99x2,4%; p=0,013. O parasitismo cardíaco dos animais C57BL/6 deficientes na sintase do óxido nítrico induzível infectados pela cepa Colombiana foi significativamente maior que o destes mesmos animais infectados com a cepa Y (2,78x0,17 ninhos/mm²; p=0,004 assim como, os animais C57BL/6 infectados com a cepa Colombiana (2,78x1,33 ninhos/mm²; p=0,006 ou cepa Y (2,78x0,53 ninhos/mm²; p=0,005. Os dados reforçam o papel do óxido nítrico no controle do parasitismo e sugerem seu papel na proteção tecidual, controlando a inflamação e potencialmente diminuindo lesões cardíacas durante a fase aguda na doença de Chagas experimental.Chagas disease is caused by Trypanosoma cruzi and the heart is the organ most affected. Nitric oxide has notable anti-Trypanosoma action, but with little evidence regarding its role in the mechanism for tissue injury. The objective of this study was to analyze the contribution of nitric oxide towards the development of inflammation and cardiac fibrosis during the acute phase of experimental infection by Y and Colombian strains of Trypanosoma cruzi. The inflammation was significantly more intense in animals infected with the Colombian strain, compared with those infected with the Y strain, both in C57BL/6

  12. Níveis plasmáticos de vitamina A em crianças carentes com pneumonia na fase aguda e após recuperação Plasma vitamin A levels in deprived children with pneumonia during the acute phase and after recovery

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    Rosangela da Silva

    2005-04-01

    Full Text Available OBJETIVO: Comparar os níveis plasmáticos de retinol em crianças de baixo nível socioeconômico com pneumonia, antes e depois da resolução do processo infeccioso; investigar a associação entre os níveis plasmáticos de retinol, após a resolução da infecção, com algumas variáveis socioeconômicas, a condição nutricional e a gravidade da pneumonia. MÉTODOS: Estudo de coorte prospectivo desenvolvido com 40 crianças, hospitalizadas por pneumonia, na faixa etária de 6 meses a 5 anos. Foram avaliados o nível plasmático de retinol na fase aguda e após a resolução da infecção, a escolaridade do chefe da família, a renda per capita, o peso ao nascer, a condição nutricional, os níveis de hemoglobina e a gravidade da pneumonia. RESULTADOS: O valor médio de retinol plasmático após a resolução do processo infeccioso foi maior em relação à fase aguda da infecção (1,4±0,6 versus 1,7±0,6 µmol/l, p = 0,03. A freqüência de níveis inadequados de retinol (OBJECTIVE: The aim of this study was to examine the plasma retinol of children in the acute phase of pneumonia and after recovery and to investigate the association between plasma levels of retinol after recovery with socioeconomic variables, nutritional status and severity of pneumonia. METHODS: A prospective cohort study which included 40 low-income hospitalized children with pneumonia, aged 6 months to 5 years. We evaluated: plasma retinol level during the acute phase and after recovery, years of schooling of the head of the family, per capita income, birth weight, nutritional status, hemoglobin levels and severity of pneumonia. RESULTS: Mean plasma retinol levels were significantly higher after recovery than during the acute phase of infection (1.4±0.6 vs. 1.7±0.6 µmol/l, p = 0.03. The frequency of inadequate plasma retinol levels (< 1.05 µmol/l was 32.5 and 17.5% for the acute phase and after recovery, respectively. There were no statistically significant

  13. Serum protein concentrations, including acute phase proteins, in calves with hepatogenous photosensitization Teores séricos de proteínas, inclusive proteínas de fase aguda, em bovinos com fotossensibilização hepatógena

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    J.J. Fagliari

    2007-12-01

    Full Text Available One hundred 6- to 12-month-old Nelore calves were allotted into control group (G1; 50 healthy calves and photosensitization group (G2; n= 50. Blood samples were collected 12 to 24 hours after the onset of dermatitis (M1, and 15 to 30 days after that (M2, at time of resolution of clinical signs. Serum protein electrophoresis was performed by means of sodium dodecyl sulphate-polyacrylamide gel electrophoresis. Eighteen serum proteins with molecular weights ranging from 16,000 to 189,000 daltons (Da were identified in all calves. In M1 and M2 serum concentrations of proteins with molecular weights of 115,000Da (ceruloplasmin, 61,000Da (a1-antitrypsin, 45,000Da (haptoglobin, and 40,000Da (acid glycoprotein were significantly increased in calves. In conclusion, measurement of serum acute phase protein concentrations may be useful in monitoring the progression of bovine hepatogenous photosensitization, including guide probable alteration on therapeutic procedures.Foram examinados 100 bezerros da raça Nelore com 6 a 12 meses de idade, distribuídos em: grupo controle (G1; 50 bezerros sadios e grupo fotossensibilização (G2; n= 50. As amostras de sangue foram coletadas 12 a 24 horas após o início da dermatite (M1 e 15 a 30 dias após (M2, época da cura das lesões cutâneas. O proteinograma sérico foi obtido por eletroforese em gel de acrilamida. Em todos os bezerros foram identificadas 18 proteínas com pesos moleculares (PM entre 16.000 a 189.000 dáltons (Da. Em M1 e M2, as concentrações séricas das proteínas de PM 115.000Da (ceruloplasmina, 61.000Da (1-antitripsina, 45.000Da (haptoglobina e 40.000Da (glicoproteína ácida foram significativamente maiores em bezerros com fotossensibilização hepatógena em comparação com aquelas dos animais do grupo-controle. A determinação dos teores séricos de proteínas de fase aguda pode ser útil no monitoramento da progressão da fotossensibilização hepatógena em bovinos, inclusive orientando

  14. Influência da resposta inflamatória de fase aguda nos níveis séricos de retinol e da proteína de ligação do retinol em pacientes com AIDS Influence of acute-phase inflammatory response on serum levels of retinol and retinol binding protein in HIV/AIDS patients

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    Fábio Fernandes Neves

    2010-02-01

    Full Text Available INTRODUÇÃO: a hiporretinolemia constitui fator prognóstico independente em pacientes com AIDS, e a atividade inflamatória causa redução dos níveis séricos deste nutriente na população em geral. Entretanto, faltam estudos que avaliem o impacto da atividade inflamatória sobre o nível sérico do retinol em pacientes com AIDS. MÉTODOS: foram avaliados transversalmente 41 pacientes internados por complicações da AIDS, que tiveram quantificados alguns marcadores de inflamação (proteína C reativa e fator de necrose tumoral alfa e concentrações séricas de retinol e da proteína de ligação do retinol. RESULTADOS: apesar da baixa (14,6% prevalência de hiporretinolemia evidenciou-se correlação negativa dos marcadores de inflamação com os níveis séricos de retinol e de sua proteína de ligação nos pacientes com AIDS. CONCLUSÕES: a atividade inflamatória de fase aguda está associada a baixos níveis séricos de retinol em indivíduos com AIDS.INTRODUCTION: Hyporetinolemia is an independent prognostic factor in AIDS patients. Inflammatory activity causes a reduction in the serum levels of this nutrient in the general population. However, there are no studies assessing the impact of inflammatory activity on the serum retinol level in AIDS patients. METHODS: A cross-sectional assessment was conducted on 41 patients hospitalized due to AIDS complications. Inflammatory markers (C-reactive protein and tumor necrosis factor-alpha and serum retinol and retinol binding protein concentrations were quantified. RESULTS: Despite the low (14.6% prevalence of hyporetinolemia, a significant negative correlation was observed between the inflammatory markers and the serum retinol and retinol binding protein levels in AIDS patients. CONCLUSIONS: Acute-phase inflammatory activity is associated with low serum retinol levels in individuals with AIDS.

  15. Notas sobre apendicitis aguda

    OpenAIRE

    Méndez S., Martín

    2011-01-01

    Hacer un buen diagnóstico, tener el valor de la responsabilidad operando precozmente los enfermos, en los cuales después de minucioso examen se cree o se tiene certeza de una apendicitis aguda, es uno de los méritos de todo buen cirujano. Sin duda tendrá que luchar contra todo, la familia, el enfermo y los allegados; pero si triunfa y vence logrará éxitos y salvará vidas. Parece fácil diagnosticar unaapendicitis aguda y sin embargo, es necesario decirlo claro, nada hay tan complicado y en oca...

  16. Citocinas e proteínas de fase aguda do soro como marcadores de regressão da resposta inflamatória ao tratamento da tuberculose pulmonar Cytokines and acute phase serum proteins as markers of inflammatory regression during the treatment of pulmonary tuberculosis

    Directory of Open Access Journals (Sweden)

    Eliana Peresi

    2008-11-01

    Full Text Available OBJETIVO: Analisar o padrão de citocinas pró- e antiinflamatórias e da resposta de fase aguda (RFA como marcadores de resposta ao tratamento da tuberculose pulmonar. MÉTODOS: Determinação dos níveis de interferon-gama (IFN-γ, tumor necrosis factor-alpha (TNF-α, fator de necrose tumoral-alfa, interleucina-10 (IL-10 e transforming growth factor-beta (TGF-β, fator transformador de crescimento-beta, pelo método ELISA, em sobrenadante de cultura de células mononucleares do sangue periférico e monócitos, assim como dos níveis de proteínas totais, albumina, globulinas, alfa-1-glicoproteína ácida (AGA, proteína C reativa (PCR e velocidade de hemossedimentação (VHS em 28 doentes com tuberculose pulmonar, em três tempos: antes (T0, aos três meses (T3 e aos seis meses (T6 de tratamento, em relação aos controles saudáveis, em um único tempo. RESULTADOS: Os pacientes apresentaram valores maiores de citocinas e RFA que os controles em T0, com diminuição em T3 e diminuição (TNF-α, IL-10, TGF-β, AGA e VHS ou normalização (IFN-γ e PCR em T6. CONCLUSÕES: PCR, AGA e VHS são possíveis marcadores para auxiliar no diagnóstico de tuberculose pulmonar e na indicação de tratamento de indivíduos com baciloscopia negativa; PCR (T0 > T3 > T6 = referência pode também ser marcador de resposta ao tratamento. Antes do tratamento, o perfil Th0 (IFN-γ, IL-10, TNF-α e TGF-β, indutor de e protetor contra inflamação, prevaleceu nos pacientes; em T6, prevaleceu o perfil Th2 (IL-10, TNF-α e TGF-β, protetor contra efeito nocivo pró-inflamatório do TNF-α ainda presente. O comportamento do IFN-γ (T0 > T3 > T6 = controle sugere sua utilização como marcador de resposta ao tratamento.OBJECTIVE: To evaluate the pattern of pro-inflammatory cytokines, anti-inflammatory cytokines and the acute phase response (APR as markers of the response to treatment of pulmonary tuberculosis. METHODS: Twenty-eight patients with pulmonary tuberculosis

  17. Insuficiencia respiratoria aguda

    OpenAIRE

    Gutiérrez Muñoz, Fernando R.

    2010-01-01

    La función respiratoria básica es el intercambio gaseoso de oxígeno y dióxido carbono; lo que implica un perfecto equilibrio y control entre los componentes del sistema respiratorio. a insuficiencia respiratoria aguda (IRA) es la incapacidad del sistema respiratorio de cumplir su función básica, que es el intercambio gaseoso de oxígeno y dióxido de carbono. Basic respiratory function is gas exchange of oxygen and carbon dioxide, which implies a perfect balance and control between the compo...

  18. Notas sobre apendicitis aguda

    Directory of Open Access Journals (Sweden)

    Martín Méndez S.

    1933-04-01

    apendicitis aguda y sin embargo, es necesario decirlo claro, nada hay tan complicado y en ocasiones tan oscuro. Sin duda, a medida que los conocimientos clínicos se extienden, se va iluminando el campo, antes inexplorado, de la cirugía apendicular, y hoy día casi todos los médicos y cirujanos tienen un criterio científico muy bien formado para lograr hacer un buen diagnóstico y aconsejar o llevar a cabo una intervención quirúrgica.

  19. Gingivitis ulceronecrosante aguda

    Directory of Open Access Journals (Sweden)

    Eduardo de la Teja-Ángeles

    2015-11-01

    Full Text Available La gingivitis ulcerativa necrosante, conocida por sus siglas en inglés como GUN (anteriormente se le conocía como enfermedad de Vincent o “boca de trinchera” por afectar a soldados en guerra, es una enfermedad poco frecuente.1-6 Se caracteriza por ser una infección aguda y dolorosa en la que las encías sangran, hay necrosis de las papilas interdentales y ataque al estado general.

  20. Hepatitis viral aguda

    Directory of Open Access Journals (Sweden)

    Héctor Rubén Hernández Garcés

    1998-10-01

    Full Text Available Se realizó una revisión bibliográfica de las hepatitis virales agudas sobre aspectos vinculados a su etiología. Se tuvieron en cuenta además algunos datos epidemiológicos, las formas clínicas más importantes, los exámenes complementarios con especial énfasis en los marcadores virales y el diagnóstico positivoA bibliographical review of acute viral hepatitis was made taking into account those aspects connected with its etiology. Some epidemiological markers, the most important clinical forms, and the complementary examinations with special emphasis on the viral markers and the positive diagnosis were also considered

  1. ming-fa hsieh

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. MING-FA HSIEH. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1179-1187. Preparation, characterization of chitosan/bamboo charcoal/poly(methacrylate) composite beads · DOROTHY CAMINOS-PERUELO WEI-CHIEH WANG ...

  2. Fase aguda da doença de Chagas na Amazônia brasileira: estudo de 233 casos do Pará, Amapá e Maranhão observados entre 1988 e 2005 Acute phase of Chagas disease in the Brazilian Amazon region: study of 233 cases from Pará, Amapá and Maranhão observed between 1988 and 2005

    Directory of Open Access Journals (Sweden)

    Ana Yecê das Neves Pinto

    2008-12-01

    Full Text Available Foram estudados 233 casos de fase aguda da doença de Chagas, oriundos do Pará, Amapá e Maranhão, observados no período de 1988 a 2005, cento e sessenta deles retrospectivamente de 1988 a 2002 e setenta e três prospectivamente de 2003 a 2005. Entre os casos estudados 78,5% (183/233 faziam parte de surtos provavelmente por transmissão oral, acometendo em média 4 pessoas e 21,5% (50/233 eram casos isolados. Foram considerados casos agudos aqueles que apresentaram exames parasitológicos diretos (a fresco, gota espessa ou Quantitative Buffy Coat - QBC e/ou IgM anti-Trypanosoma cruzi positivos. Foram feitos ainda xenodiagnósticos em 224 pacientes e hemoculturas em 213. Todos foram avaliados clinica e epidemiologicamente. As manifestações clínicas mais freqüentes foram febre (100%, cefaléia (92,3%, mialgia (84,1%, palidez (67%, dispnéia (58,4%, edema de membros inferiores (57,9%, edema de face (57,5% dor abdominal (44,2%, miocardite (39,9% e exantema (27%. O eletrocardiograma mostrou alterações de repolarização ventricular em 38,5% dos casos, baixa voltagem de QRS em 15,4% e desvio de SAQRS em 11,5%, extra-sístoles ventriculares em 5,8%, bradicardia em 5,8% e taquicardia em 5,8%, bloqueio de ramo direito em 4,8% e fibrilação atrial em 4,8%. A alteração mais freqüente vista no ecocardiograma foi o derrame pericárdico em 46,2% dos casos. Treze (5,6% pacientes evoluíram para o óbito, 10 (76,9% dos quais por comprometimento cardiovascular, dois por complicações de origem digestiva e um de causa mal definida.Two hundred and thirty-three cases of the acute phase of Chagas disease, from Pará, Amapá and Maranhão, were observed between 1988 and 2005. One hundred and sixty were studied retrospectively from 1988 to 2002 and seventy-three were prospectively followed up from 2003 to 2005. Among the cases studied, 78.5% (183/233 formed part of outbreaks, probably due to oral transmission (affecting a mean of 4 individuals, and 21

  3. REFORMA TRIBUTARIA EN FASES

    Directory of Open Access Journals (Sweden)

    Ricardo Chávez

    2016-01-01

    Full Text Available En este artículo el principal objetivo es analizar tanto cualitativa como cuantitati- vamente el impacto del momento de una reforma tributaria, es decir, el aumento progresivo y avisado (en fases de los impuestos en contraposición con una reforma de una sola vez. Los resultados indican que una reforma en fase debiera producir dos efectos: un efecto sustitución que impulsa a las empresas a adelantar inversión y con ello debiera aumentar el Producto Interno Bruto ( PIB y la inflación. La reacción del banco central debiera ser subir la tasa de interés. El otro efecto es negativo y consiste en un efecto riqueza que reduce el precio de las acciones y aumenta el tipo de cambio, Tomando como ejemplo el caso de Chile, que realizó una reforma en base recientemente (2014: se tiene que un aumento de 1% de los impuestos debería producir, producto de la distorsión intertemporal, un aumento de 0.17% en el PIB dentro del primer año del anuncio. No obstante, pueden existir otros elementos de naturaleza muy heterogénea que pueden influenciar negativamente la implemen- tación de la reforma y, por tanto, cancelar por completo este efecto de sustitución intertemporal. Entre estos elementos negativos se tiene la falta de claridad de la re- forma por parte del gobierno, al grado de virulencia de las discusiones en el Congre- so y su influencia en las expectativas de los empresarios, la falta de credibilidad, por ejemplo, la incertidumbre de nuevas alzas de impuestos, etcétera.

  4. Plan Exportador FA. INTI.

    OpenAIRE

    Herrera Arias, Francisco

    2009-01-01

    El desarrollo del presente trabajo de grado, constituye un trabajo en equipo entre la Secretaria de Desarrollo Económico de la Alcaldía Mayor de Bogotá D.C., el CIDEM de la Universidad del Rosario y Maloka. La metodología aplicada del CIDEM a la empresa FA. INTI. se ha aplicado a mas de 1000 PYMES colombianas y ha sido coordinada por Francisco Herrera Arias y dirigida por la Dr. Luz Sofía Méndez y un equipo profesional de consultores. El plan exportador cuenta con información general de la em...

  5. Adverse prognostic influence of diabetes mellitus and hyperglycemia on the clinical course of brain infarct: a review of its causes with special reference to the pathogenesis of hyperglycemia in the acute phase of stroke Influência prognóstica adversa do diabetes mellitus e da higergliœmia sobre a evolução do infarto cerebral uma revisão de suas causas com menção aos mecanismos de gênese da hiperglicemia na fase aguda do acidente vascular encefálico

    Directory of Open Access Journals (Sweden)

    Charles André

    1992-06-01

    Full Text Available In non-diabetic patients, the appearance of hyperglycemia in the acute phase of stroke is related to the extension of cellular injury, and hence to the physiologic stress response. In animal models of ischemic insult, the deleterious effects of hyperglycemia depend heavily on the production of lactic acid «via» activation of the glycolitic anaerobic pathway. The abnormal production of lactic acid and consequent tissular acidosis appear mainly in the early post-reperfusion period, or in states of marked but partial reduction of blood flow. A direct reduction of cerebral blood flow and, perhaps, the production of a hyperosmolar state may contribute to worsening of the ischemic injury. In diabetic patients, previous hemoreologic and microcirculatory changes, and a greater susceptibility to infections may additionally reduce the chances of complete recovery after stroke.A gênese da hiperglicemia surgida na fase aguda do AVE em pacientes não diabéticos correlaciona-se basicamente ao grau de injúria celular e, portanto, à gravidade da reação fisiológica de «stress». Experimentalmente, o efeito deletério da hiperglicemia após a lesão isquêmica parece depender, em primeiro lugar, do acúmulo intracelular de ácido lático, gerado pela via glicolítica anaeróbica. Este acúmulo anormal de ácido lático, e consequente acidose tissular, parece ocorrer especialmente na fase inicial de reperfusão, ou na presença de fluxo sanguíneo residual - isquemia parcial. Fatores adicionais invocados para explicar o agravamento do insulto isquêmico pela hiperglicemia são a redução do fluxo sanguíneo cerebral e, talvez, a produção de um estado hiperosmolar. Em pacientes diabéticos alterações hemorreológicas e microcirculatórias específicas, bem como maior susceptibilidade às complicações infecciosas, vêm somar-se, para tornar também comum uma evolução clínica desfavorável.

  6. Ataxias agudas en la infancia

    Directory of Open Access Journals (Sweden)

    Yaline Betancourt Fursow

    2013-09-01

    Full Text Available La ataxia cerebelosa aguda infantil (ACAI es la forma más frecuente de complicación neurológica por el virus de la varicela.Descritas dentro del grupo de las cerebelitis agudas. Los objetivos de este estudio fueron: evaluar la presentación clínica, manejo y seguimiento de niños hospitalizados con ACAI en un hospital pediátrico terciario donde la inmunización para varicela no está disponible (parte I y describir los diagnósticos diferenciales de la cerebelitis aguda (parte II. Estudiamos 95 pacientes. Los criterios diagnósticos de ataxia aguda se basaron en: pérdida aguda de la coordinación o dificultad para la marcha con o sin nistagmo asociado y duración menor de 48 horas, en un niño previamente sano. Estos criterios se cumplían en todos los casos valorados, excepto en las ataxias secundarias a ingesta de tóxicos, en los que la duración debía ser menor de 24 horas para su inclusión en el estudio. Se registraron los datos en una historia clínica pediátrica y neurológica. Entre los pacientes inmunosuprimidos la incidencia mayor fue la complicación por varicela. La mayoría de los pacientes fueron varones. El rango de edad fue la preescolar, 5 años . El intervalo entre la presentación del rash y el ingreso fue de 1 a 3 días. El estudio de LCR se practicó en 59.5% de los casos. La TAC y la resonancia magnética cerebral (RM presentaron edema en el 33.3%. El aciclovir endovenoso fue utilizado en 23 pacientes; pero no hubo diferencias significativas en las manifestaciones clínicas y seguimiento entre tratados y no tratados. La ataxia fue la primera manifestación clínica. La estadía hospitalaria fue de 4 días (rango: 2-11 días.

  7. Pneumonia aguda fibrinosa e organizante

    Directory of Open Access Journals (Sweden)

    Cláudia Santos

    2010-07-01

    Full Text Available Resumo: O padrão histológico de Pneumonia Aguda Fibrinosa e Organizante (AFOP – Acute Fibrinous And Organizing Pneumonia, descrito por Beasley em 2002, caracteriza-se pela existência de fibrina intra-alveolar sob a forma de bolas de fibrina e pneumonia organizativa difusa. A apresentação clínica desta doença intersticial pulmonar pode ser aguda ou subaguda, diferindo no entanto dos outros padrões histológicos habitualmente associados a lesão pulmonar aguda – Lesão Alveolar Difusa (DAD, Pneumonia Organizativa (OP e Pneumonia Eosinofílica (EP.A propósito deste tema, os autores fazem uma revisão da literatura e descrevem o caso clínico de um doente de 44 anos, com aspectos imagiológicos e evolução pouco habituais. Abstract: The histologic pattern of Acute Fibrinous and Organizing Pneumonia (AFOP, described by Beasley in 2002, is characterized by the existence of intra alveolar fibrin in the form of fibrin “balls” and diffuse organizing pneumonia. Presenting symptoms of this interstitial pulmonary disease can be acute or subacute. However, it differs from the well-recognized histologic patterns of acute pulmonary lesion – Diffuse Alveolar Damage (DAD, Organizing Pneumonia (OP and Eosinophilic Pneumonia (EP.The authors carry out a review of the literature concerning this topic and describe the clinical case of a 44-year-old patient with unusual imaging features and outcome. Palavras-chave: AFOP, bolas de fibrina, pneumonia organizativa, Key-word: AFOP, fibrin balls, organizing pneumonia

  8. Glomerulonefritis aguda post-infecciosa asociada a neumonía neumocócica Acute post infectious glomerulonephritis associated to pneumococcal pneumonia

    OpenAIRE

    S. Fernández de Miguel; E. de Goicoechea Manzanares; M. Gaboli; J.M. Sánchez Granados; V. Murga Herrera

    2009-01-01

    Presentamos un niño de 6 años con insuficiencia renal aguda secundaria a glomerulonefritis asociada a neumonía neumocócica. El paciente presentó en primer lugar un síndrome nefrítico con hematuria, proteinuria, oliguria, edemas y deterioro de la función renal, siendo diagnosticado a continuación de neumonía con derrame pleural. La función renal se normalizó tras 72 horas, persistiendo una hipertensión arterial que precisó tratamiento en la fase aguda. El cuadro se resolvió sin secue...

  9. FASCODE for the environment (FASE)

    Energy Technology Data Exchange (ETDEWEB)

    Snell, H.E.; Moncet, J.L. [Atmospheric and Environmental Research, Inc., Cambridge, MA (United States); Anderson, G.P.; Chetwynd, J.H. [Phillips Lab., Hanscom AFM, MD (United States)] [and others

    1996-04-01

    The Optical Physics Division of the Phillips Laboratory, with support from the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Program, is developing a state-of-the-art line-by-line atmospheric radiative transfer model as the successor to FASCODE. The goal of this project is to create a computationally efficient model which contains the most up-to-date atmospheric physics. The new model, known as FASCODE for the Environment, or {open_quotes}FASE{close_quotes}, will combine the best features of FASCODE and LBLRTM, the DOE`s standard radiative transfer model. FASE will also contain new features such as new cross-sections for heavy molecules, and improved solar irradiance model, and improvements to the Schumann-Runge bands and continuum. The code will be optimized for vectorized and/or parallel processing. put under configuration control for easy maintenance, and structured into separate modules for each function: atmospheric profiles, layer optical properties, radiative transfer, multiple-scattering, etc. This modular structure will allow for increased flexibility and easy customization of the code for specialized applications, such as a forward model for iterative inversion algorithms. Ease-of-use will be enhanced with improved input control structures and documentation to accommodate the needs of novice and advanced users. This paper addresses changes which have been made to FASCODE and LBLRTM to create FASE, and gives an overview of the modular structure and its capabilities.

  10. Differential responsiveness of obese (fa/fa) and lean (Fa/Fa) Zucker rats to cytokine-induced anorexia.

    Science.gov (United States)

    Plata-Salamán, C R; Vasselli, J R; Sonti, G

    1997-01-01

    Pathophysiological and pharmacological concentrations of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) in the cerebrospinal fluid (CSF) induce anorexia in normal rats. Obesity in humans and rodents is associated with increased TNF-alpha messenger RNA and protein levels in various cell types. This suggests that obese individuals may have differential regulation of cytokine production and dissimilar responsiveness to cytokines. In the present study, we investigated the effects of the intracerebroventricular (ICV) microinfusion of TNF-alpha (50, 100, and 500 ng/rat), IL-1 beta (1.0, 4.0, and 8.0 ng), and TNF-alpha (100 ng) plus IL-1 beta (1.0 ng) on obese (fa/fa) and lean (Fa/Fa) Zucker rats. The results show that: TNF-alpha and IL-1 beta, and the concomitant administration of TNF-alpha and IL-1 beta decreased the short-term (4 hours), nighttime (12 hours), and total daily food intakes in obese and lean rats; IL-1 beta was more potent relative to TNF-alpha; obese rats showed greater responsiveness to IL-1 beta: 8.0 ng IL-1 beta, for example, decreased the 12-hour food intake by 52% in obese and 22% in lean rats. On the other hand, obese and lean rats did not exhibit a significantly different responsiveness to the anorexia induced by 50, 100, or 500 ng TNF-alpha at the 4-hour period; and the concomitant ICV administration of TNF-alpha and IL-1 beta induced anorexia with additive (4-hour period) or synergistic (12-hour and 24-hour periods) effects in obese rats. The effect of TNF-alpha plus IL-1 beta in lean rats was greater than additive for the 12-hour and 24-hour periods. The difference in suppression of total daily food intake by TNF-alpha plus IL-1 beta in obese (-43%) versus lean (-23%) rats was significantly different (p < 0.01). The results show that obese (fa/fa) and lean (Fa/Fa) Zucker rats have differential responsiveness to the ICV microinfusion of two different classes of cytokines.

  11. Leucemia congénita aguda

    Directory of Open Access Journals (Sweden)

    Nilvia Esther González García

    2011-06-01

    Full Text Available La leucemia aguda durante el período neonatal es poco frecuente de evolución rápida y pronóstico sombrío. Sus características clínicas y biológicas difieren de las encontradas en niños de mayor edad, y su inicio se caracteriza por afectación cutánea, hepatoesplenomegalia, hiperleucocitosis e infiltración del sistema nervioso central. Se han observado pacientes con formas tanto mieloides como linfoides, pero la leucemia mieloide aguda parece predominar en esta etapa de la vida. Se presenta el caso de un paciente con leucemia congénita clasificada morfológicamente, con aparición de manifestaciones clínicas de enfermedad hematológica desde el nacimiento y diagnóstico de leucemia linfoblástica aguda congénita.

  12. Avaliação do antígeno SAG2a recombinante de Toxoplasma gondii como um potencial marcador diagnóstico para Toxoplasmose humana aguda

    OpenAIRE

    Béla, Samantha Ribeiro

    2007-01-01

    Proteínas recombinantes têm sido utilizadas para o diagnóstico sorológico da infecção por Toxoplasma gondii para diferenciar entre as fases aguda e crônica da toxoplasmose. Neste estudo, foi avaliada a reatividade de anticorpos IgG e IgG1 através de imunoensaios em soros de pacientes com toxoplasmose aguda e crônica dirigidos contra dois antígenos recombinantes clonados e expressos em E. coli, SAG2A (molécula recombinante total) e SAG2A(DELTA) (molécula recombinante deletada do...

  13. Pancreatitis aguda grave asociada a gangrena vesicular

    OpenAIRE

    Arroyo-Sánchez, Abel S; Aguirre-Mejía, Rosa Y; Echenique-Martínez, Sergio E

    2014-01-01

    Se presenta el caso un paciente diabético que desarrolló un cuadro de pancreatitis aguda grave asociada a gangrena vesicular, en el que se evaluó la aplicabilidad de los criterios de clasificación y manejo de la hoja de ruta para pancreatitis aguda, así mismo se proponen algunos tópicos que pudieran ser investigados a futuro We present a diabetic patient who developed severe acute pancreatitis associated to gallbladder gangrene, in this case we assessed the applicability of classification ...

  14. FA

    African Journals Online (AJOL)

    spamer

    have been extracted annually from the sea and inland waters since 1989 (F ... and the relationships with the environment are examined .... India. 0008–15°N. –. 1948–1988. 00448. 070. 006.4. Peru. 000 5 –18°N. –. 1958 – ..... process (e.g. water column stability, convergence) .... In Climate Change and Fish Popula- tions.

  15. Pneumonia aguda fibrinosa e organizante

    Directory of Open Access Journals (Sweden)

    C. Damas

    2006-09-01

    Full Text Available Resumo: A designação acute fibrinous and organizing pneumonia (AFOP foi proposta por Beasley et al para os casos em que as características histopatológicas das lesões não se enquadravam em outras situações clínicas (agu-das ou subagudas conhecidas. A presença de fibrina intra alveolar e de pneumonia organizativa, com distribuição difusa, é a principal alteração histológica associada a esta entidade.Os autores descrevem o caso de um doente do sexo masculino, com o diagnóstico de AFOP, por bióp-sia pulmonar cirúrgica. O doente teve uma apresentação subaguda, apresentando por queixas principais tosse, dor torácica e febre. TAC torácica mostrou infiltrados bilaterais, difusos. Após início de corticoterapia sistémica e ciclofosfamida, o doente apresentou melhoria clínica significativa. Ao elaborar este caso, os autores esperam acrescentar mais alguns dados sobre esta nova entidade.Rev Port Pneumol 2006; XII (5: 615-620 Abstract: The term Acute Fibrinous and Organizing Pneumonia (AFOP has been proposed by Beasley et al for cases that not fit into the histopathologic criteria of the recognized entities described as acute or subacute clinical presentations. The presence of intra-alveolar fibrin in the form of fibrin ‘balls’ and organizing pneumonia with patchy distribution are the main histological features of this entity. We describe the case of a male patient with the diagnostic of AFOP made by surgical lung biopsy. He had a subacute presentation of symptoms consisting of productive cough, chest pain and fever. Bilateral infiltrates with patchy and diffuse distribution were the predominant features in his chest HRCT scan. The patient had a good clinical course after a treatment with prednisone and cyclophosphamide. Our hope in reporting this case study is to add some more data to the discussion of this new entity.Rev Port Pneumol 2006; XII (5: 615-620 Palavras

  16. Application Of FA Sensor 2

    International Nuclear Information System (INIS)

    Park, Seon Ho

    1993-03-01

    This book introduces FA sensor from basic to making system, which includes light sensor like photo diode and photo transistor, photo electricity sensor, CCD type image sensor, MOS type image sensor, color sensor, cds cell, and optical fiber scope. It also deals with direct election position sensor such as proximity switch, differential motion, linear scale of photo electricity type, and magnet scale, rotary sensor with summary of rotary encoder, rotary encoder types and applications, flow sensor, and sensing technology.

  17. VIH: Infeccion aguda, pesquisa y manejo

    Directory of Open Access Journals (Sweden)

    Cortés S. Esteban, Dr.

    2014-05-01

    Si bien existe una relativa facilidad para realizar el diagnóstico de un paciente con la infección crónica por VIH, existe por otro lado una relativa dificultad para realizar el diagnóstico de la infección aguda en etapas tempranas de la infección. Esta situación es de importancia desde el punto de vista de la Salud Pública por cuanto en la infección aguda es cuando se producen las viremias más elevadas y por tanto la mayor facilidad para que el sujeto sea infectante y disemine la infección viral.

  18. Bases moleculares de las leucemias agudas

    Directory of Open Access Journals (Sweden)

    G. Martínez Antuña

    2006-04-01

    Full Text Available El gran desarrollo de la biología molecular en los últimos años ha contribuido a un importante avance en los conocimientos relacionados con las bases moleculares de las leucemias agudas (LA. Ademas de profundizar en la biología de estas enfermedades y conocer las bases moleculares, ha renido también gran impacto en mejorar el resultado de los tratamientos y disminuir la toxicidad de las terapias.

  19. Otomastoidite Aguda em Criança

    Directory of Open Access Journals (Sweden)

    João Araújo

    2017-09-01

    Full Text Available Criança de 2 anos, sexo masculino, diagnóstico de otite média aguda bilateral, medicada inicialmente com amoxicilina + clavulanato 90 mg/kg/dia desde há 7 dias, internada por agravamento do quadro à esquerda, com edema e eritema retroauricular, apagamento do sulco retroauricular [...] Recebido: 07/09/2015 · Aceite: 7/01/2016

  20. Comportamiento de la otitis media aguda

    Directory of Open Access Journals (Sweden)

    Gladys Fuentes Fernández

    Full Text Available Introducción: la otitis media aguda es una complicación de las infecciones respiratorias agudas altas, frecuente en los niños menores de 5 años. Objetivos: caracterizar su comportamiento, según edad y sexo, e identificar algunos factores de riesgo en este grupo de edad. Métodos: se realizó un estudio descriptivo retrospectivo de 554 niños ingresados en el hospital Pediátrico de Centro Habana con el diagnóstico de otitis media aguda, durante los años 2006-2010. Los datos se recogieron de las historias clínicas. Resultados: la otitis media aguda fue más frecuente en el sexo masculino (58,7 % y en los menores de 1 año (53,1 %. El antecedente de bajo peso (33,9 % y la prematuridad (27,5 %, la asistencia a círculos infantiles (43,5 % y el hábito de fumar de los padres (58,4 %, además del antecedente de ingresos hospitalarios por otitis media en el mes previo a la aparición del episodio actual (59,0 %, constituyeron los principales factores de riesgo en el presente estudio. Conclusiones: la otitis media es una causa frecuente de ingresos hospitalarios, y se identifican como principales factores de riesgo la asistencia a círculos infantiles y el tabaquismo de algunos de los padres.

  1. Resultados do tratamento da pancreatite aguda grave

    Directory of Open Access Journals (Sweden)

    Franz Robert Apodaca-Torrez

    Full Text Available OBJETIVO: Avaliar os resultados do Protocolo de Atendimento de pacientes com diagnóstico de pancreatite aguda grave. MÉTODOS: Foram analisados, consecutivamente, a partir de janeiro de 2002, idade, sexo, etiologia, tempo de internação, tipo de tratamento e mortalidade de 37 pacientes portadores de pancreatite aguda grave. RESULTADOS: A idade dos pacientes variou de 20 a 88 anos (média de 50 anos; 27% foram do sexo feminino e 73% do masculino. O tempo médio global de internação foi 47 dias. Treze pacientes foram tratados cirurgicamente; a média de operações realizadas foi duas por paciente. Ocorreram seis óbitos dentre os pacientes submetidos ao tratamento cirúrgico (46% e dois óbitos no grupo submetido somente ao tratamento clínico (8,3%. A mortalidade global foi 21% CONCLUSÃO: Após a modificação na forma de abordagem dos pacientes com pancreatite aguda grave, houve diminuição da mortalidade e uma tendência para a conduta expectante.

  2. Soporte nutricional en la insuficiencia renal aguda

    Directory of Open Access Journals (Sweden)

    O. Cristina Olivos, Dra.

    2010-07-01

    Full Text Available La insuficiencia renal aguda (IRA se presenta frecuentemente en distintas condiciones clínicas y es especialmente frecuente en unidades de cuidados intensivos. La presencia de IRA se considera como un factor de riesgo independiente de morbilidad y mortalidad hospitalaria. De ahí la importancia de evaluar los diversos factores determinantes de su evolución, entre los que cuenta la desnutrición calórico-proteica. El propósito de esta revisión es analizar la literatura más relevante hasta la actualidad en este tema.

  3. Intoxicaciones agudas en pediatría

    Directory of Open Access Journals (Sweden)

    Yalena Prado Vizcaíno

    2011-12-01

    Full Text Available Introducción: las intoxicaciones han sido en los últimos años una importante causa de aumento de la morbilidad y mortalidad en edades pediátricas. Objetivo: determinar el comportamiento clínico de las intoxicaciones agudas en la etapa de enero de 2005 a diciembre de 2009 en el Hospital Pediátrico "William Soler". Métodos: el estudio se realizó en el Hospital "William Soler". Se revisaron las historias clínicas, los registros de intoxicaciones agudas y las tarjetas de codificación de egresos hospitalarios por intoxicaciones de los pacientes llegados al hospital en esta etapa. Resultados: se recibieron en el hospital 886 pacientes. El grupo de mayor frecuencia de intoxicaciones fue el de 1 a 5 años, con predominio del sexo masculino, aunque sin diferencias significativas con respecto al sexo femenino. Las intoxicaciones más frecuentes fueron por medicamentos, fundamentalmente psicofármacos y antibióticos, seguido por alimentos y por productos químicos del hogar. El 30,2 % de los casos fueron ingresados. Conclusiones: estos resultados nos hacen pensar en la necesidad de estar alertas y crear acciones encaminadas a proteger o evitar las intoxicaciones en edades tan vulnerables.

  4. INSUFICIENCIA RENAL AGUDA CON UREMIA NORMAL EN PACIENTE MONO-RENO SECUNDARIA A PIELONEFRITIS AGUDA

    Directory of Open Access Journals (Sweden)

    Musso CG

    2006-03-01

    Full Text Available RESUMEN:La insuficiencia renal aguda es un sindrome que característicamente cursa con niveles plasmáticos elevados de urea y creatinina. Sin embargo, hay situaciones clínicas en las cuales este sindrome puede cursar con un incremento de la creatininemia sin presentar elevación de la uremia.En este reporte presentamos un caso clínico de una insuficiencia renal aguda con uremia normal secundaria a una pielonefritis aguda en un paciente con riñón único. El paciente presentaba una elevada excreción fraccional de urea lo cual podía explicar su uremia normal pese a estar cursando una caída del filtrado gomerular. Dicha excreción de urea elevada fue interpretada como secundaria a una diabetes insipida nefrogénica y una alteración en el recirculado intra-renal de la urea ambos producto de la pielonefritis aguda. Concluimos que la pielonefritis aguda en un paciente mono-reno puede presentarse con un patrón de insuficiencia renal aguda con uremia normal. SUMMARYAcute renal failure is a syndrome that usually runs with an increase in creatinine and urea plasma levels. However, there are clinical situations in which this syndrome may run with an increase in plasma creatinine keeping normal the urea one.In this report we present a case of acute renal failure with normal plasma urea level secondary to an acute pyelonephritis in a single kidney patient. The patient had an increased fractional excretion of urea which could explain the normal plasma urea levels found despite of his reduced glomerular filtration. This increased urea excretion state was interpreted as a consequence of the nephrogenic diabetes insipidus and alteration of the intra-renal urea reciclying process that the acute pyelonephritis induced. In conclusion: Acute pyelonephritis in a single kidney patient can appear as a pattern of acute renal failure with normal plasma urea levels.

  5. INSUFICIENCIA RENAL AGUDA CON UREMIA NORMAL EN PACIENTE MONO-RENO SECUNDARIA A PIELONEFRITIS AGUDA

    Directory of Open Access Journals (Sweden)

    Musso CG

    2007-04-01

    Full Text Available RESUMENLa insuficiencia renal aguda es un sindrome que característicamente cursa con niveles plasmáticos elevados de urea y creatinina. Sin embargo, hay situaciones clínicas en las cuales este sindrome puede cursar con un incremento de la creatininemia sin presentar elevación de la uremia. En este reporte presentamos un caso clínico de una insuficiencia renal aguda con uremia normal secundaria a una pielonefritis aguda en un paciente con riñón único. El paciente presentaba una elevada excreción fraccional de urea lo cual podía explicar su uremia normal pese a estar cursando una caída del filtrado gomerular. Dicha excreción de urea elevada fue interpretada como secundaria a una diabetes insipida nefrogénica y una alteración en el recirculado intra-renal de la urea ambos producto de la pielonefritis aguda. Concluimos que la pielonefritis aguda en un paciente mono-reno puede presentarse con un patrón de insuficiencia renal aguda con uremia normal.SUMMARYAcute renal failure is a syndrome that usually runs with an increase in creatinine and urea plasma levels. However, there are clinical situations in which this syndrome may run with an increase in plasma creatinine keeping normal the urea one. In this report we present a case of acute renal failure with normal plasma urea level secondary to an acute pyelonephritis in a single kidney patient. The patient had an increased fractional excretion of urea which could explain the normal plasma urea levels found despite of his reduced glomerular filtration. This increased urea excretion state was interpreted as a consequence of the nephrogenic diabetes insipidus and alteration of the intra-renal urea reciclying process that the acute pyelonephritis induced. In conclusion: Acute pyelonephritis in a single kidney patient can appear as a pattern of acute renal failure with normal plasma urea levels.

  6. Insuficiencia renal aguda con necrosis tubular aguda secundaria a picadura masiva de abejas

    Directory of Open Access Journals (Sweden)

    Gustavo A. Aroca - Martínez

    2006-01-01

    Full Text Available Leñador de 46 años consulta al servicio de nefrología, de la Clínica Renal de la Costa en Barranquilla, con episodio de insuficiencia renal aguda 48 horas después de haber sufrido múltiples picaduras por abejas africanizadas. Durante su estancia hospitalaria presentó incremento de enzimas musculares (AST LDH, y de pruebas de función renal, motivo por el cual fue dializado en varias ocasiones. Con mejoría total, se decide egresar y manejar ambulatoriamente. Se concluye que el caso se trata de una insuficiencia renal por necrosis tubular aguda por rabdomiolisis debida a la picadura múltiple de abejas africanizadas.

  7. Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass

    DEFF Research Database (Denmark)

    Arora, Tulika; Seyfried, Florian; Docherty, Neil G

    2017-01-01

    Roux-en-Y gastric bypass (RYGB) and duodenal jejunal bypass (DJB), two different forms of bariatric surgery, are associated with improved glucose tolerance, but it is not clear whether the gut microbiota contributes to this effect. Here we used fa/fa rats as a model of impaired glucose tolerance...... to investigate whether (i) the microbiota varies between fa/fa and nondiabetic fa/+ rats; (ii) the microbiota of fa/fa rats is affected by RYGB and/or DJB; and (iii) surgically induced microbiota alterations contribute to glucose metabolism. We observed a profound expansion of Firmicutes (specifically......, Lactobacillus animalis and Lactobacillus reuteri) in the small intestine of diabetic fa/fa compared with nondiabetic fa/+ rats. RYGB-, but not DJB-, treated fa/fa rats exhibited greater microbiota diversity in the ileum and lower L. animalis and L. reuteri abundance compared with sham-operated fa/fa rats in all...

  8. Falla cardíaca aguda

    OpenAIRE

    Sénior Sánchez, Juan Manuel; Gándara Ricardo, Jairo Alfonso

    2015-01-01

    Se presenta el caso clínico de una mujer de 26 años de edad, que acudió al Hospital Universitario San Vicente Fundación (Medellín) con síntomas y signos de falla cardíaca aguda y diagnóstico previo de falla cardíaca crónica con fracción de expulsión disminuida, de origen no claro, tromboembolismo pulmonar y ataque cerebrovascular isquémico, sin modulación neurohormonal óptima. Ingresó a la institución con hallazgos clínicos de sobrecarga hídrica y baja perfusión tisular, con requerimiento de ...

  9. Coréia aguda na gravidez

    Directory of Open Access Journals (Sweden)

    Walter C. Pereira

    1967-12-01

    Full Text Available São apresentados doze casos de coréia aguda observados entre 150.000 gestantes (1/12.500. A maioria dos surtos ocorreu no segundo trimestre da primeira gravidez. A duração média dos sintomas foi de três meses, não tendo sido registrado caso algum de óbito materno. Todos os partos foram espontâneos e normais. Houve apenas um óbito fetal conseqüente a choque hemorrágico. São tecidas considerações a propósito dos aspectos clínico, laboratorial e prognóstico da coréia gravídica, sendo focalizado mais pormenorizadamente o problema fisiopatogênico dessa afecção.

  10. Exacerbação aguda da fibrose pulmonar idiopática

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    Natália Melo

    2009-03-01

    Full Text Available Resumo: Alguns doentes com fibrose pulmonar idiopática (FPI apresentam durante a sua evolução fases de agravamento clínico sem causa conhecida, designadas como “exacerbação aguda” ou “fase acelerada” da doença (EA. Caracterizam-se pelo agravamento marcado da dispneia, hipoxemia e pelo aparecimento de novas opacidades pulmonares ou pelo agravamento das já existentes no estudo imagiológico. Os achados histológicos típicos são o dano alveolar difuso (DAD sobreposto a alterações de pneumonia intersticial usual (UIP. Esta entidade clínica associa-se a uma mortalidade elevada, não havendo até ao momento nenhuma terapêutica de comprovada eficácia.Os autores descrevem os casos clínicos de cinco doentes que apresentaram alterações clínicas, funcionais e radiológicas sugestivas de EA-FPI, assim como o tratamento efectuado e a evolução observada, enquadrando-os na discussão das características normalmente apresentadas por esta entidade. Abstract: Some patients with Idiopathic Pulmonary Fibrosis (IPF have disease accelerated deterioration without identifiable cause referred as “acute exacerbation” or “accelerated stage”. It is characterized by severe worsening of dyspnea, hypoxemia and new or progressive opacities on imaging studies. The typical histological findings are diffuse alveolar damage in addition to the features of usual interstitial pneumonia pattern. Mortality in this clinical entity is very high and no efficacious therapeutic have been described.The authors describe the clinical, functional and radiological features, treatment and evolution of five patients with IPF acute exacerbation. A discussion will be carry out concerning the IPF acute exacerbation usual features comparing with the alterations noticed in those patients. Palavras-chave: Fibrose pulmonar idiopática, exacerbação aguda, Key words: Idiopathic

  11. Surto de toxoplasmose aguda transmitida através da ingestão de carne crua de gado ovino

    Directory of Open Access Journals (Sweden)

    Bonametti Ana Maria

    1997-01-01

    Full Text Available Os autores apresentam 17 casos de toxoplasmose aguda sintomática adquirida pela ingestão de carne crua de carneiro, servida em uma festa à qual todos os pacientes compareceram. Em relação ao quadro clínico, o período de incubação da doença variou de 6 a 13 dias (10,9 ± 7,0 e 16 (94,5% pacientes apresentaram febre, cefaléia, mialgia, artralgia e adenomegalia (cervical ou cervical/axilar. Outros sinais clínicos encontrados foram: hepatomegalia em 6 pacientes, esplenomegalia em 4 e exantema em 2. Um paciente apresentou quadro clínico de corioretinite, confirmada através de exame oftalmológico. Todos os pacientes apresentavam títulos séricos de anticorpos específicos (IgG e IgM que evidenciavam fase aguda de toxoplasmose, pela Reação de Imunofluorescência Indireta. Todos os pacientes foram tratados especificamente e houve boa resposta clínica e laboratorial ao tratamento.

  12. La trombectomía mecánica en el tratamiento de accidentes cerebrovasculares (ACV en la fase aguda

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    Alain Bonafe

    2013-08-01

    Full Text Available En Francia, la incidencia anual de accidentes cerebro vasculares (ACV es de 1.6 a 2.4 por cada mil (1.000 personas, es decir entre 100.000 y 145.000 por año, con una mortalidad del 15 al 20% al cabo del primer mes y un 75% de personas sobrevivientes con secuelas. El tratamiento de preferencia es la Trombólisis IV (Intra Venosa con rt-PA (Recombinant Tissue Plasminogen Activator - Activador del Plasminógeno Tisular Recombinante, el cual tiene una ventana de eficacia de 4 horas y media después del inicio de los síntomas. Sólo 2% de los pacientes eligibles para este tratamiento se benefician de una fibrinólisis por vía venosa. Las oclusiones de arterias de calibre grueso son responsables del 46% de los accidentes cerebrovasculares Isquémicos (ACVI y predicen una sobremortalidad y discapacidad funcional severa a los 6 meses. En ausencia de revascularización, la mitad de los ACVI de circulación anterior con oclusión arterial documentada fallece y solamente el 10% de ellos, tienen un buen pronóstico funcional a los tres meses. Algunas variables que han sido identificadas como predictoras de un mal pronóstico son: un puntaje clínico en la escala NIHSS (National Institute of Health Stroke Scale - Escala del Ictus del Instituto Nacional de la Salud superior a 12 según Fischer 2005, una oclusión documentada de una arteria intracraneal, los fracasos y las contraindicaciones de la fibrinólisis intravenosa entre otros. Esta revisión busca presentar los mecanismos, la evaluación, la eficacia y las complicaciones reportadas por la literatura sobre la trombectomía mecánica.

  13. La trombectomía mecánica en el tratamiento de accidentes cerebrovasculares (ACV) en la fase aguda

    OpenAIRE

    Alain Bonafe

    2013-01-01

    En Francia, la incidencia anual de accidentes cerebro vasculares (ACV) es de 1.6 a 2.4 por cada mil (1.000) personas, es decir entre 100.000 y 145.000 por año, con una mortalidad del 15 al 20% al cabo del primer mes y un 75% de personas sobrevivientes con secuelas. El tratamiento de preferencia es la Trombólisis IV (Intra Venosa) con rt-PA (Recombinant Tissue Plasminogen Activator - Activador del Plasminógeno Tisular Recombinante), el cual tiene una ventana de eficacia...

  14. Fases de cultivo: Establecimiento y crecimiento rapido

    Science.gov (United States)

    R. Kasten Dumroese; Douglass F. Jacobs; Kim M. Wilkinson

    2012-01-01

    En este capítulo y en el siguiente, se analizan en detalle las fases de crecimiento por las cuales pasa todo cultivo. Cabe recordar que para llegar a esta instancia se deben haber realizado varios pasos previos en forma adecuada, como el tratamiento de las semillas, la limpieza de contenedores y su llenado con medio de crecimiento de buena calidad. Estos temas se han...

  15. Esofagitis necrotizante aguda: Una entidad inusual

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    Silvana E. Pramparo

    2010-12-01

    Full Text Available La esofagitis necrotizante aguda (ENA, también denominada esófago negro, es una rara enfermedad poco descripta en la literatura médica. Describimos el caso de un hombre de 80 años, con hemorragia digestiva alta quien desarrolló un esófago negro luego de un episodio de hipotensión. La necrosis fue confirmada histológicamente. Los pacientes se presentan con hematemesis y melena en más del 70% de los casos. Los hallazgos endoscópicos muestran una coloración negruzca de la mucosa esofágica. El diagnóstico se realiza con endoscopia y confirmación histológica. La mortalidad es alta (más del 50% aunque relacionada a las enfermedades de base del paciente. Por último, podemos decir que la sospecha es muy importante en el diagnóstico de ENA, particularmente en pacientes ancianos con enfermedades asociadas y evidencia de hemorragia digestiva alta. En este trabajo describimos las características clínicas, endoscópicas e histopatológicas de un paciente con ENA.

  16. Designing Urban Media Façades

    DEFF Research Database (Denmark)

    Dalsgaard, Peter; Halskov, Kim

    2010-01-01

    Media façades comprise a category of urban computing concerned with the integration of displays into the built environment, including buildings and street furniture. This paper identifies and discusses eight challenges faced when designing urban media façades. The challenges concern a broad range...... of issues: interfaces, physical integration, robustness, content, stakeholders, situation, social relations, and emerging use. The challenges reflect the fact that the urban setting as a domain for interaction design is characterized by a number of circumstances and socio-cultural practices that differ from...

  17. Abordando las enfermedades respiratorias agudas en niños con un Enfoque Ecológico en la Comunidad

    Directory of Open Access Journals (Sweden)

    Francisco Lamus-Lemus

    2015-01-01

    Full Text Available Objetivos: Disminuir los episodios de enfermedad respiratoria aguda (ERA en las familias, mediante un enfoque modificado del modelo ecológico de Morelatto para identificar y tra-bajar colectivamente determinantes que influyen en la salud respiratoria de niños y niñas.Materiales y Métodos: Durante el proceso se realizaron actividades encaminadas a pre-venir las principales causas de ERA basadas en el modelo transteórico del comportamiento con el fin de generar cambios conductuales en las familias. Para ello se creó una escala de valoración del riesgo de ERA como instrumento de medición de la efectividad de las activi-dades realizadas, otorgándole a cada familia un puntaje antes y después de la intervención para determinar si hubo disminución del mismo. Resultados: Las actividades realizadas conducen a cambios evidenciados en las prácticas cotidianos de las madres y sus familias, reflejadas en la escala de valoración de riesgos a partir de la disminución de conductas que favorecen la enfermedad respiratoria aguda y sus complicaciones en la primera infancia afiliada a la FA R -Génesis.Conclusiones: Una menor exposición a eventos y complicaciones de la ERA en miembros de grupos familiares de la FA R -Génesis puede contribuir a mejorar la resiliencia y dismi-nuir la vulnerabilidad socioeconómica de las familias afectadas regularmente por la ERAsus complicaciones.

  18. Lesiones periapicales agudas en pacientes adultos

    Directory of Open Access Journals (Sweden)

    María Elena Fernández Collazo

    2012-06-01

    Full Text Available Se realizó un estudio analítico de corte transversal en el área de salud del Policlínico "27 de Noviembre" del municipio Marianao, La Habana, en el periodo correspondiente de enero a diciembre de 2009. Se incluyeron todos los pacientes que acudieron al servicio de urgencia y que presentaron lesiones periapicales agudas. Se recogió información de las variables edad, sexo, grupo dentario, causa de la enfermedad, características clínicas e higiene bucal. Esta última se clasificó en las categorías eficiente y deficiente según el índice simplificado de higiene bucal. Se utilizó el X² para estimar la relación entre las variables, y la comparación de proporciones para contrastar la hipótesis de que existieran diferencias entre las lesiones periapicales para las categorías de las variables grupo dentario, causa de la enfermedad y características clínicas. Se encontró un predominio del absceso periapical agudo en un 84,7 % del grupo de edad de 35 a 59 años y del sexo masculino, aunque no se encontraron diferencias significativas para estas variables, ni en los grupos dentarios con respecto a la enfermedad. La higiene bucal resultó estar relacionada con las lesiones periapicales. Se encontraron diferencias significativas en las lesiones periapicales respecto a todas las causas estudiadas, con excepción de las enfermedades periodontales. Respecto a las características clínicas hubo significación en cuanto al aumento de volumen del fondo del surco vestibular y la movilidad dentaria.

  19. Plantas indicadoras de clomazone na fase vapor

    Directory of Open Access Journals (Sweden)

    Fábio Schreiber

    2013-10-01

    Full Text Available A volatilização representa um processo importante no deslocamento de agrotóxicos para o ambiente. As características físico-químicas da molécula do clomazone indicam que este possui potencial de volatilização. Em vista do exposto, para a realização deste estudo, foram conduzidos dois experimentos com o objetivo de avaliar a suscetibilidade das espécies: pepino, melão, milho, sorgo e arroz a diferentes formulações do herbicida clomazone na fase vapor. Para isso, foram utilizadas caixas de vidro hermeticamente fechadas, com a presença de diferentes formulações de clomazone e as espécies vegetais. As formulações utilizadas foram Gamit 360 CS®, Gamit 500 EC® e Gamit Star®. Com os resultados obtidos, foi possível concluir que, dentre as espécies avaliadas, independente da formulação utilizada, a de menor tolerância ao herbicida clomazone na fase vapor foi o sorgo, seguido do milho e do arroz.

  20. Les faïences patronymiques

    Directory of Open Access Journals (Sweden)

    Jean Rosen

    2006-09-01

    Full Text Available Les faïences patronymiques, collection Jeanne Lemerle - Donation Michel Dillange,J. Rosen (dir., D. Donadieu-Rigaut, J.-M. Roudier, S. Biton, A. Supiot,Le Mans, éd. de la Reinette, 2006, 158 p.A la suite d’une récente donation, le Musée de l’Abbaye Sainte-Croix des Sables-d’Olonne présente un exceptionnel ensemble de cent soixante-cinq faïences patronymiques nivernaises rassemblé dans les années 1930-1940, ensemble très complet produit des environs de 1730 aux années 1830, qui constitue un p...

  1. Resultados de la fase de engorde en invernaderos

    OpenAIRE

    Sonnenholzner, Stanislaus

    2002-01-01

    Resultados de la fase de engorde en invernaderos Continuando con la serie de experimentos que se están desarrollando en la estación experimental Pesglasa para evaluar el efecto del tratamiento térmico en la supervivencia del camarón, se realizó la fase de engorde en invernaderos.

  2. Injúria Renal Aguda no paciente politraumatizado Acute Renal Injury in polytrauma patients

    Directory of Open Access Journals (Sweden)

    Thiago Gomes Romano

    2013-03-01

    Full Text Available A Injúria Renal Aguda (IRA no contexto do paciente politraumatizado ocorre, na maioria das vezes, por uma conjuntura de fatores que passam por eventos correlacionados à ressuscitação volêmica inicial, ao grau de resposta inflamatória sistêmica associada ao trauma, ao uso de contraste iodado para procedimentos diagnósticos, à rabdomiólise e à síndrome compartimental abdominal. Atualmente, passamos por uma fase de uniformização dos critérios diagnósticos da IRA com o Acute Kidney Injury Network (AKIN, sendo a referência mais aceita. Consequentemente, o estudo da IRA no politraumatismo também passa por uma fase de reformulação. Esta revisão da literatura médica visa trazer dados epidemiológicos, fisiológicos e de implicação clínica para o manuseio destes pacientes, bem como expor os riscos do uso indiscriminado de expansores volêmicos e particularidades sobre a instituição de terapia renal substitutiva em indivíduos sob risco de hipertensão intracraniana.Acute Kidney Injury (AKI in trauma is, in most cases, multifactorial. Factors related to the initial ressuscitation protocol, degree of the systemic inflamatory response to trauma, contrast nephropathy in diagnostic procedures, rhabdomyolysis and abdominal compartment syndrome are some of those factors. Nowadays a uniformization in diagnostic criteria for AKI has been proposed by the Acute Kidney Injury Network (AKIN and as a result the incidence of AKI and its impact in outcomes in trauma patients also needs to be reconsider. In this review we aim to approach epidemiologic, physiologic and clinical relevant data in the critical care of patients victims of trauma and also to expose the risks of indiscriminate use of volume expanders and the interaction between renal replacement theraphy and intracranial hypertension.

  3. Miopia aguda induzida por topiramato: relato de dois casos

    Directory of Open Access Journals (Sweden)

    Kathy Dadam Sgrott

    2011-06-01

    Full Text Available RESUMO A miopia aguda pode ser desencadeada pelo uso de medicações sistêmicas, dentre elas, o anticonvulsivante topiramato. Este trabalho descreve dois casos de pacientes jovens com quadro agudo bilateral de miopia induzida por terapia com topiramato para controle de síndrome depressiva, fazendo relação com casos semelhantes descritos na literatura e revisão bibliográfica pertinente.

  4. Manejo de desechos peligrosos (II fase

    Directory of Open Access Journals (Sweden)

    Juan Carlos Salas Jiménez

    2006-05-01

    Full Text Available Este trabajo corresponde a la segunda fase del proyecto de Manejo de Desechos Peligrosos que se generan en los laboratorios del Instituto Tecnológico de Costa Rica (ITCR, el cual continuó con las etapas de implementación de un sistema de gestión de manejo de desechos en los laboratorios de docencia e investigación del ITCR. Las actividades que se desarrollaron fueron: capacitación e implementación de algunas etapas del sistema de gestión, cuantificación y caracterización de los desechos, desarrollo de un programa para el control de inventarios y pruebas de laboratorio para el tratamiento de los desechos peligrosos de mayor volumen. De esta investigación, se obtuvieron los siguientes resultados: 1.Se cuenta con un grupo de funcionarios comprometidos y capacitados para implementar el sistema de gestión. 2. Tres métodos efectivos para los tres desechos que se generan en gran cantidad de masa o volumen. 3. Un sistema de inventarios estandarizados que ha sido instalado en nueve laboratorios de la Sede de Cartago. 4.Una “Guía de manejo de los desechos peligrosos de los laboratorios del ITCR”, que sirva de documento base para los funcionarios de los laboratorios. 5. Una normativa en trámite de aprobación para institucionalizar el Programa de Manejo de desechos peligrosos.

  5. LA ULTIMA FASE. LA ELIMINACIÓN

    Directory of Open Access Journals (Sweden)

    Rafael Nájera Morrondo

    2013-01-01

    Full Text Available En este artículo se presentan lo que se considera la última fase de la erradicación de la poliomielitis en España, la cual llevó 25 años, duran- te el período 1963-88, a raiz del brusco descenso que produjo en la incidencia de la enfermedad la introducción de la vacuna Sabin con cepas atenuadas en el año 1963. Ello debería haber conducido a la desaparición de la enfermedad en un corto período de tiempo, aunque no fue así a causa de la disminución de la vacunación y la vigilancia epidemiológica, que no se retomaron con seriedad hasta 1976. El último caso autóctono se produjo en 1988. Tras asumir Rafael Nájera la dirección del centro Nacional de Microbiología, Virología e Inmunología Sanitarias, el primer objetivo de su equipo fue la erradicación de la poliomielitis de nuestro país, introduciendo los criterios de clasificación de la OMS y los estudios de caracterización intertípica de las cepas aisladas de virus.

  6. Serie de 8 casos de parotiditis supurada aguda neonatal

    Directory of Open Access Journals (Sweden)

    Manuel Díaz Álvarez

    Full Text Available La parotiditis supurada aguda es una infección poco frecuente en la práctica del pediatra y neonatólogo. El objetivo es mostrar nuestra experiencia en la atención de serie de casos con parotiditis supurada aguda en el período neonatal, y describir sus características de presentación. Se presentan los hallazgos clínicos en 8 pacientes con parotiditis supurativa neonatal, quienes estuvieron ingresados en el Servicio de Neonatología del Hospital Pediátrico Universitario "Juan Manuel Márquez", durante el período de 22 años (desde el año 1992 hasta el año 2013, y se contrasta con los reportes publicados en la literatura internacional. Las características de presentación de la parotiditis aguda supurada de nuestros casos concuerdan con la literatura revisada en muchos aspectos, y se demuestra que es, además, una infección poco frecuente en el período neonatal. Es la primera publicación sobre esta entidad en neonatos en Cuba, y la mayor serie de casos en el ámbito latinoamericano.

  7. International Façades - CROFT. Climate Related Optimized Façade Technologies

    Directory of Open Access Journals (Sweden)

    Marcel Bilow

    2012-04-01

    Full Text Available Looking at Central European building projects illustrates an awareness of sustainability and the need to save energy. This trend is based on the finiteness of natural resources, and is thus wise to follow. Developments in this region including passive house technologies, and energy plus solutions that create more energy than they use have become realisable. But it is not increasing technological knowledge alone that supported these developments; the Central European climate makes it possible to invent technological solutions that allow for maximum comfort while maintaining low energy consumption. Other regions have experienced a building boom over the past decades that has dramatically increased city sizes. A detailed examination of such building projects illustrates that most of them strive for the international standard with a high glazing ratio in the style of the Central European examples. But how can architecture be transferred to regions with entirely different climate conditions? The answer lies in the technological possibilities we have at our disposal today. The main research question of this thesis refers to utilising the local climate. Which methods are necessary to plan a building - and a façade as the interface between the inside and the outside, in particular - while working with, not against the climate? Sailing has been used as an analogy: only with the knowledge of winds and tides can we use them to efficiently move across bodies of water. Those who have not learned or understood this will have to use a motorboat and pay the price for petrol. Chapter 2 ‘Climate zones’ describes the different climate zones and their particularities, analysed with the help of eight different boomtowns. The mild Central European climate becomes particularly apparent when compared to tropic locations such as Singapore. Here, very high average temperatures and humidity levels require that we rethink and find new solutions. In chapter 3

  8. Mecanismos del daño celular en la insuficiencia renal aguda Mechanisms of cell damage in acute renal failure

    Directory of Open Access Journals (Sweden)

    José Martínez

    1989-01-01

    Full Text Available

    Los mecanismos del da no celular en la insuficiencia renal aguda Incluyen alteraciones en la producción de energía, la permeabilidad celular y el transporte de calcio. Dichas alteraciones producen cambios progresivos en la estructura celular que pueden ser reversibles si desaparece la causa que llevó a la falla renal, excepto cuando se alcanza la fase final de la lesión de la membrana y se llega a necrosis celular. Este mismo fenómeno probablemente ocurre tambIén en situaciones clínicas.

    The mechanisms of cellular damage In acute renal failure Include alterations In energy production, cell membrane permeability and calcium transport. These changes lead to progressive damage of the whole cellular structure which In general can be reversible If the precipitating cause disappears, except when the final stages of cell membrane lesion take place and cellular necrosis has occurred. This phenomenon probably applies for the clinical settling as well.

  9. Alterations of local cerebral glucose utilization in lean and obese fa/fa rats after acute adrenalectomy.

    Science.gov (United States)

    Doyle, P; Rohner-Jeanrenaud, F; Jeanrenaud, B

    1994-08-29

    An animal model often used to investigate the aetiology of obesity is the genetically obese fa/fa rat. It has many abnormalities, including hyperphagia, hyper-insulinemia, insulin resistance, low cerebral glucose utilization and an overactive hypothalamo-pituitary adrenal (HPA) axis with resulting hypercorticism. Due to the latter consideration, the aim of this work was to study the impact of acute adrenalectomy (ADX) on the local cerebral glucose utilization (LCGU) of lean and obese fa/fa rats. ADX resulted in discrete increases in LCGU of regions common to both lean and obese rats. These common regions were found to belong to be related to the limbic system. Within this system, the LCGU of the brain of obese rats was either normalized to lean sham operated values or increased by ADX to a similar degree in both groups on a percentage basis. It was concluded that the LCGU of both lean and obese animals appears to be negatively regulated, albeit to different extents, by glucocorticoids. Such negative regulation is particularly salient within the limbic system of the lean rat and even more so in the fa/fa rat. It is suggested that the long-term hypercorticism of obese fa/fa rats due to abnormal regulation of the HPA axis may result in a decreased LCGU in limbic and related regions of the brain of fa/fa rats and contribute to the expression of the obese phenotype.

  10. Study of acute hepatotoxicity of Equisetum arvense L. in rats Estudo da hepatotoxicidade aguda da Equisetum arvense L. em ratos

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    Nilo César do Vale Baracho

    2009-12-01

    Full Text Available PURPOSE: To evaluate the acute hepatotoxicity of Equisentum arvense L. in rats. METHODS: Fifty Wistar rats were used, these being divided in four groups, one being the control (receiving only water and the other groups receiving graded doses of Equisentum arvense L. (30, 50, and 100mg/kg respectively for 14 days. Blood samples were obtained to determine TGO, TGP, FA, DHL and GT-gamma activities. After that, hepatic tissue samples were collected for the anatomopathologic analysis. RESULTS: The anatomopathologic exam of the hepatic tissue showed organ with preserved lobular structure. In the same way, there was no significant change in the seric activities of the hepatic enzymes when compared to control group. CONCLUSION: The oral treatment with graded doses of Equisentum arvense L. was not able to produce hepatic changes. Further studies are necessary to evaluate the chronic hepatotoxicity of Equisentum arvense L. in rats.OBJETIVO: Investigar a hepatotoxicidade aguda da Equisetum arvense L. em ratos. MÉTODOS: foram utilizados 50 ratos Wistar, os quais foram divididos em quatro grupos, sendo um controle (recebendo apenas água e os outros grupos recebendo doses crescentes de cavalinha (30, 50 e 100mg/Kg, respectivamente por 14 dias. Foram coletadas amostras de sangue para determinação da atividade sérica de TGO, TGP, FA, DHL e gama-GT. Em seguida, foram obtidas amostras de tecido hepático para análise anatomopatológica. RESULTADOS: O exame anatomopatológico de tecido hepático demonstrou órgão com estrutura lobular preservada. Da mesma forma, não houve alteração significativa na atividade sérica das enzimas hepáticas, quando comparado ao grupo controle. CONCLUSÃO: O tratamento com doses crescentes de Equisetum arvense L., não induziu hepatotoxicidade aguda em ratos. Novos estudos são necessários para avaliar a hepatoxicidade crônica de Equisetum arvense L. em ratos.

  11. en fase líquida

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    Alba Nelly Ardila Arias

    2007-01-01

    Full Text Available Se comparó la reactividad del hidrógeno puro, el isopropanol y el ácido fórmico como agentes reductores en la hidrodecloración catalítica de percloroetileno en fase líquida con 0,8% Pd/TiO2 sol-gel bajo condiciones de reacción moderadas. Además, se estudió el efecto de la cantidad de agua y de hidróxido de sodio adicionados a la mezcla de reacción. Los catalizadores frescos y usados se caracterizaron por espectroscopia de absorción atómica (AAS, quimisorción de H2,adsorción-desorción de N2, difracción de rayos X (DRX, reducción con hidrógeno a temperatura programada (TPR-H2, análisis termogravimétrico (TGA-DTG, espectroscopia de reflectancia difusa UV-Vis (UV-Vis DRS, desorción de NH3 a temperatura programada (TPD-NH3 y microscopía de transmisión electrónica (TEM. Los mejores resultados de HDC se obtuvieron con hidrógeno e isopropanol como agentes reductores. La adición de NaOH aumenta significativamente la conversión del PCE con los tres agentes reductores; no obstante, es importante optimizar la cantidad que se debe adicionar, ya que un exceso afecta negativamente la reacción de HDC. Los resultados de la caracterización realizada a los catalizadores frescos y usados revela ciertos cambios como: disminución del área superficial, incremento de la acidez superficial, disminución de la dispersión y aumento en el tamaño de las partículas de paladio. Sin embargo, algunas características como la carga de paladio, la estructura cristalina del soporte y los estados de oxidación del paladio no se modificaron.

  12. Leucemia congénita aguda Acute congenital leukemia

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    Nilvia Esther González García

    2011-06-01

    Full Text Available La leucemia aguda durante el período neonatal es poco frecuente de evolución rápida y pronóstico sombrío. Sus características clínicas y biológicas difieren de las encontradas en niños de mayor edad, y su inicio se caracteriza por afectación cutánea, hepatoesplenomegalia, hiperleucocitosis e infiltración del sistema nervioso central. Se han observado pacientes con formas tanto mieloides como linfoides, pero la leucemia mieloide aguda parece predominar en esta etapa de la vida. Se presenta el caso de un paciente con leucemia congénita clasificada morfológicamente, con aparición de manifestaciones clínicas de enfermedad hematológica desde el nacimiento y diagnóstico de leucemia linfoblástica aguda congénita.Acute leukemia during neonatal period is not frequent, of a fast course and gloomy prognosis. Its clinical and biological features differ of that present in older children and it onset is characterized by cutaneous affection, hepatosplenomegaly, hyperleukocytosis and infiltration of central nervous system (CNS. There are patients presenting with myeloid and lymphoid types, but the acute leukemia seems to predominate in this stage of life. This is the case of a patient with acute leukemia morphologically classified, with appearance of clinical manifestations of hematologic disease from birth and a diagnosis of congenital acute lymphoblastic leukemia.

  13. Classificação de gravidade na pancreatite aguda

    Directory of Open Access Journals (Sweden)

    Tercio De Campos

    Full Text Available De acordo com a Classificação de Atlanta a pancreatite aguda pode ser dividida, baseado em sua severidade, em uma forma leve ou grave. Uma série de aspectos têm sido discutidos nos últimos anos, tais como, quantas categorias de gravidade devem ser consideradas; se o doente com falência orgânica é igual ao doente com necrose infectada; qual o papel da falência orgânica transitória; e como avaliar a falência orgânica. A reunião de revista"Telemedicina Baseada em Evidência - Cirurgia do Trauma e Emergência" (TBE-CiTE realizou uma avaliação crítica de artigos relacionados a este tema, considerando três artigos recentes que delinearam duas grandes revisões publicadas nos últimos meses. Estes artigos sugerem a classificação de gravidade em três ou quatro categorias, ao invés de pancreatite aguda leve ou grave, além de discutir qual o melhor escore para avaliar a falência orgânica. As seguintes recomendações foram propostas: (1 A pancreatite aguda deve ser classificada em quatro categorias: leve, moderada, grave e crítica, o que permite uma melhor determinação das características dos doentes; (2 Avaliação de falência orgânica com um escore de gravidade, preferencialmente algum que avalie diretamente cada falência orgânica, tais como o SOFA e o MODS (Marshall. O SOFA parece ter maior acurácia, mas o MODS tem melhor aplicabilidade devido à facilidade de uso.

  14. Ataxia cerebelar aguda na criança

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    Valeriana Moura Ribeiro

    1968-03-01

    Full Text Available São relatados os casos de 6 crianças com ataxia cerebelar aguda. Admitem os autores a presença de um fator etiológico de caráter viral comum a todos êles, discutindo os mecanismos patogênicos com base nos casos da literatura. A evolução foi favorável em todos os pacientes, com regressão completa da sintomatologia, dentro do período de 6 a 60 dias.

  15. Insuficiencia renal aguda inducida por mordedura de serpiente Bothrops

    Directory of Open Access Journals (Sweden)

    Gustavo A. Aroca Martínez

    2014-01-01

    Full Text Available Mujer de 58 años de edad, remitida a urgencias por presentar cuadro clínico de insuficiencia renal aguda (IRA secundaria a mordedura de serpiente (Bothrops Atrox. Ingresa hipotensa con elevación de azoados e hiperkalemia, ecografía renal dentro de parámetros normales. Se maneja terapia dialítica con lo cual presenta mejoría clínica. En este reporte se detallan aspectos del diagnóstico, manejo clínico y posibles mecanismos fisiopatológicos que explican el daño renal.

  16. Framework for benchmarking FA-based string recognizers

    CSIR Research Space (South Africa)

    Ngassam, EK

    2010-10-01

    Full Text Available of suggested algorithms by domain-specific FA-implementers requires prior knowledge of the behaviour (performance-wise) of each algorithm in order to make an informed choice. The authors propose a based string recognizers such that FA-implementers could capture...

  17. Odenplan: a media façade design process

    DEFF Research Database (Denmark)

    Korsgaard, Henrik; Hansen, Nicolai Brodersen; Basballe, Ditte Amund

    2012-01-01

    In this paper we present an example of how to work with the challenges inherent in media façade design processes. We base the paper on our experiences from the creation of a series of design proposals for a media façade on the Odenplan subway station in Stockholm, Sweden. We approach the question...

  18. QUANDO LA LINGUA SI FA PENSIERO

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    Daniela Finocchi

    2018-03-01

    Full Text Available Il Concorso letterario nazionale Lingua Madre, ideato nel 2005 da Daniela Finocchi, è un progetto permanente di Regione Piemonte e del Salone Internazionale del Libro di Torino diretto alle donne straniere (o di origine straniera con una sezione per le donne italiane. Nasce per creare relazione, scambio, confronto, per favorire la conoscenza reciproca e mettere in dialogo culture, identità, esperienze diverse. Tutto questo attraverso la scrittura in lingua italiana e tramite la fotografia. Una grande rete a disposizione delle donne, chiamate a raccontare e a raccontarsi in piena libertà e autonomia, a esprimersi al di fuori degli stereotipi, delle “norme” e delle “pre-iscrizioni” culturali e sociali, a giocare parti di sé tramite la parola. 
La lingua dà corpo a immaginari, desideri, mondi interiori e così si fa pensiero e diviene strumento indispensabile per conquistare il diritto a esistere e ad avere voce.   When language becomes thought The “Lingua Madre” national literary competition, founded in 2005 by Daniela Finocchi, is a permanent project of the Piedmont Region and the Turin International Book Fair aimed at foreign (born women, with a section for Italian women. It is aimed at developing relationships, exchanges, dialogues, promoting mutual knowledge and creating dialogue between different cultures, identities and experiences through writing in Italian and photography. A large network is available to women, so they can talk in full freedom and autonomy, express themselves outside stereotypes, “norms”, cultural and social prejudices and explore themselves through words. Language gives substance to ideas, desires, inner worlds, becoming thought, and is thus an indispensable tool to exist and have a voice.

  19. JPRS Report Science & Technology Japan Future Prospects of FA-From FA to IMS

    Science.gov (United States)

    1989-12-04

    of FA Investment (Large Companies) a) m d) m 5000fI~ljl|S 1 m± ¥-1$ 500~1000t| 300~500(f 1000~3000ft i) £ÜÜ 0i!§£3^ SWOT # H^fc3S j) k) 1...is a method conceived by Toyota Motors, now widely understood throughout the world. Such information as the production volume, time, method and...T. Suzuki Toyota Motor Corp. Y. Tatsue AIST, Mechanical Engineering Laboratory K. Togino Komatsu Ltd. H. Torii Nihon Keizai Shimbun Editorial

  20. O mosaico patogênico da pancreatite aguda grave

    Directory of Open Access Journals (Sweden)

    Márcio Cavalcante Carneiro

    Full Text Available A pancreatite aguda tem sido alvo de grandes discussões que vão desde o entendimento de sua fisiopatologia até a investigação de novas modalidades terapêuticas. Reconhece-se que a necrose pancreática e a falência orgânica múltipla - mormente associadas à infecção - representam os principais fatores determinantes da evolução para o óbito, mas, apesar dos grandes avanços em seu estudo, a doença permanece como um desafio para o clínico e o cirurgião. Deste modo, um melhor conhecimento dos mecanismos envolvidos em sua fisiopatologia pode ser a chave para um tratamento mais eficaz, principalmente em relação às formas graves, cuja letalidade ainda encontra-se substancialmente elevada. Baseado nestas considerações, o presente trabalho tem por objetivo a revisão bibliográfica da fisiopatologia, dos fatores patogênicos envolvidos na história natural da pancreatite aguda grave e dos eventos associados à síndrome da resposta inflamatória sistêmica e à sepse, esboçando-se assim o mosaico patogênico desta importante condição.

  1. Carambola como causa de lesão renal aguda

    Directory of Open Access Journals (Sweden)

    Karilla Lany Scaranello

    2014-04-01

    Full Text Available A carambola pertence à família das Oxalidáceas, espécie Averrhoa carambola. É rica em sais minerais, vitaminas A, C, complexo B e ácido oxálico. Estudos recentes demonstram que a toxicidade da fruta difere entre os indivíduos e pode ser explicada pelas respostas biológicas individuais como idade, quantidade da ingestão, neurotoxinas em cada tipo de fruta. Adicionalmente, a nefrotoxicidade causada pela fruta é dose dependente, podendo levar ao desenvolvimento de lesão renal aguda pela deposição de cristais de oxalato de cálcio intratubular, assim como por lesão direta das células epiteliais tubulares, levando à apoptose das mesmas. Relatamos o caso de uma paciente que, após a ingestão do suco da fruta e fruta in natura, desenvolveu lesão renal aguda, necessitando de terapia dialítica, evoluindo com desfecho favorável e recuperação da função renal.

  2. Respostas cardiovasculares agudas em ambiente virtualmente simulado pelo Nintendo Wii

    Directory of Open Access Journals (Sweden)

    Renato Aparecido de Souza

    2013-01-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2013v15n1p60 Recentemente, tem sido verificada a utilização do Nintendo Wii no contexto da saúde. O objetivo do presente estudo foi analisar as respostas cardiovasculares agudas monitoradas por meio do comportamento da frequência cardíaca, pressão arterial sistólica, pressão arterial diastólica e duplo produto, em ambiente virtualmente simulado pelo console Nintendo Wii. A amostra foi composta por 18 universitários saudáveis, com média de idade de 22,07 ± 1,34 anos. As variáveis foram observadas com uso de deltas (valor final - inicial após 25 arremessos de basquetebol em duas situações experimentais: (I com o voluntário sentado e, (II com o voluntário saltando verticalmente. Os resultados sugerem que a prática de atividade física em ambiente virtual emulado pelo Nintendo Wii é capaz de alterar as respostas cardiovasculares agudas, especialmente, quando realizada em associação a saltos verticais. Assim, os resultados sustentam a viabilidade do uso do Nintendo Wii em programas de treinamento e favorecem sua indicação de forma mais segura.

  3. Time to Detection with BacT/Alert FA Plus Compared to BacT/Alert FA Blood Culture Media.

    Science.gov (United States)

    Nutman, A; Fisher Even-Tsur, S; Shapiro, G; Braun, T; Schwartz, D; Carmeli, Y

    2016-09-01

    Rapid identification of the causative pathogen in patients with bacteremia allows adjustment of antibiotic therapy and improves patient outcomes. We compared in vitro and real-life time to detection (TTD) of two blood culture media, BacT/Alert FA (FA) and BacT/Alert FA Plus (FA Plus), for the nine most common species of bacterial pathogens recovered from blood samples. Experimental data from simulated cultures was compared with microbiology records of TTD for both culture media with growth of the species of interest in clinical blood cultures. In the experimental conditions, median TTD was 3.8 hours (23.9 %) shorter using FA Plus media. The magnitude of reduction differed between species. Similarly, in real life data, FA Plus had shorter TTD than FA media; however, the difference between culture media was smaller, and median TTD was only 1 hour (8.5 %) less. We found shorter TTD with BacT/Alert FA Plus culture media, both experimentally and in real-life conditions and unrelated to antibiotic neutralization, highlighting the importance of appropriate blood culture media selection.

  4. Mass spectrometry of the lithium adducts of diacylglycerols containing hydroxy FA in castor oil and two normal FA

    Science.gov (United States)

    Castor oil can be used in industry. The molecular species of triacylglycerols containing hydroxy fatty acids (FA) in castor oil have been identified. We report here the identification of twelve diacylglycerols (DAG) containing hydroxy FA in castor oil using positive ion electrospray ionization mass ...

  5. Escala de Alvarado como herramienta diagnóstica para apendicitis aguda

    Directory of Open Access Journals (Sweden)

    Iván Pimienta Concepción

    2017-06-01

    Full Text Available Introducción: La apendicitis aguda es la enfermedad intrabdominal más frecuente tratada de urgencia. Resulta de interés la utilización de la Escala de Alvarado en el diagnóstico de esta patología por su contribución a la disminución de apendicectomías negativas. Objetivo: Determinar la validez de la Escala de Alvarado como herramienta diagnóstica para apendicitis aguda en pacientes atendidos en el Servicio de Cirugía General del Hospital IESS Ambato. Métodos: Se realizó una investigación observacional, descriptiva y transversal en pacientes hospitalizados con cuadro de dolor abdominal y sospecha de apendicitis aguda, valorados en el Servicio de Cirugía General en el Hospital General IESS Ambato en el período junio 2015 a noviembre del año 2015. Resultados: De acuerdo al resultado histopatológico predominó la apendicitis aguda supurada con (n=83, 54.9%; seguida de apendicitis aguda gangrenosa (n=35, 23.2%; apendicitis aguda precoz (n=15, 9.9%; mientras que el resultado normal y apendicitis aguda gangrenosa perforada se encontraron con los mismos valores (n=9, 5.9%. Conclusiones: Existió un puntaje elevado de la Escala de Alvarado para el diagnóstico de apendicitis aguda según la severidad de los hallazgos descritos en el resultado histopatológico posterior a la apendicectomía. El resultado histopatológico de mayor frecuencia fue la apendicitis aguda supurada, con un riesgo medio en la Escala de Alvarado, la cual es más sensible en periodos de gravedad.

  6. Fases fluoradas como sorventes para extração em fase sólida de pesticidas e compostos perfluorados

    OpenAIRE

    Cristiane Vidal

    2015-01-01

    Resumo: Fases sólidas fluoradas apresentam características oriundas das propriedades da ligação C-F, como o alto momento de dipolo e a baixa polarizabilidade e isto confere seletividades peculiares a elas. Existem diversas fases estacionárias alquilperfluoradas e fenilperfluoradas comerciais para cromatografia líquida, entretanto, a oferta de fases sólidas fluoradas para extração em fase sólida (SPE) é menor. Assim, este trabalho descreve um novo método de SPE utilizando uma fase fluorada pre...

  7. Leucemia linfoblástica aguda (LLA durante a gravidez: um relato de caso

    Directory of Open Access Journals (Sweden)

    Marcelo Gil Cliquet

    2015-10-01

    Full Text Available A incidência de Leucemia Linfoblástica Aguda (LLA associada à gestação é pequena, entretanto, devido à gravidade da doença, é fundamental que o obstetra esteja capacitado a orientar a conduta médica. O tratamento deve ser iniciado logo após o diagnóstico para que não haja prejuízo do prognóstico materno. Quando diagnosticada, sabe-se que haverá prejuízos fetais frente à quimioterapia a ser empregada. O dilema ético criado pela concomitância de neoplasias com a gestação é de difícil manejo. Objetivo: relatar o caso de uma gestante no primeiro trimestre com diagnóstico de LLA. Metodologia: as informações foram obtidas por meio de revisão do prontuário e da literatura. Relato: Relatamos o caso de uma gestante, 30 anos, com dores articulares no joelho e hemograma com pancitopenia. O mielograma e a imunofenotipagem foram compatíveis com Leucemia Linfoblástica B comum, quando a paciente estava com 12 semanas de gestação (ultrassom. A paciente foi informada sobre todos os riscos do tratamento quimioterápico para o feto, bem como os riscos maternos em postergar o tratamento. A partir da discussão entre a paciente, seus familiares e equipe médica, ela decidiu por iniciar o tratamento com protocolo BFM 86 modificado, assinando um termo de consentimento. Durante a Indução 2, foi diagnosticado óbito fetal por ultra-sonografia (21 semanas de gestação. A paciente continuou o tratamento com suporte psicológico e no momento encontra-se em remissão completa, iniciando a fase de consolidação do referido protocolo. Conclusão: Pretendemos alertar sobre a difícil decisão feita por uma paciente grávida com a LLA. Tal escolha deve ser feita com o amparo de toda a equipe médica e familiares dos pacientes, além de ser firmada por meio de um termo de consentimento.

  8. Al CERN prima fase sistema gestione dati LHC

    CERN Multimedia

    2003-01-01

    "Al via la prima fase per la realizzazione del sistema Lhc computing Grid (LCG), progettato per elaborare le quantita' di dati senza precedenti che, a partire dal 2007, saranno prodotte dagli esperimenti eseguiti con il nuovo grande acceleratore Large Hadron Collider (LHC), presso il Cern di Ginevra" 1 page

  9. Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.

    Science.gov (United States)

    Legette, Leecole L; Luna, Arlyn Y Moreno; Reed, Ralph L; Miranda, Cristobal L; Bobe, Gerd; Proteau, Rosita R; Stevens, Jan F

    2013-07-01

    Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9 mg/kg BW for 6 weeks. All rats were maintained on a high fat (60% kcal) AIN-93G diet for 3 weeks to induce severe obesity followed by a normal AIN-93G (15% kcal fat) diet for the last 3 weeks of the study. Weekly food intake and body weight were recorded. Plasma cholesterol, glucose, insulin, triglyceride, and monocyte chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay kits. Plasma and liver tissue levels of XN and its metabolites were determined by liquid-chromatography tandem mass spectrometry. Plasma and liver tissue levels of xanthohumol were similar between low and medium dose groups and significantly (peffect on body weight and plasma glucose levels. The highest dose group (n=6) had significantly lower plasma glucose levels compared to the control group (n=6) in male but not female rats. There was also a significant decrease in body weight for male rats in the highest dose group (16.9 mg/kg BW) compared to rats that received no xanthohumol, which was also not seen for female rats. Plasma cholesterol, insulin, triglycerides, and MCP-1 as well as food intake were not affected by treatment. The findings suggest that xanthohumol has beneficial effects on markers of metabolic syndrome. Copyright © 2012. Published by Elsevier Ltd.

  10. Nefrite Intersticial Aguda Após Exposição a Losartan

    Directory of Open Access Journals (Sweden)

    Letícia Schwerz Weinert

    2007-07-01

    Full Text Available Nefrite intersticial aguda é uma causa comum de perda aguda de função renal. Exposição a drogas é o fator desencadeante mais freqüentemente relatado, porém auto-imunidade e infecções também estão associadas. Os inibidores da enzima de conversão da angiotensina têm sido relatados como possíveis agentes, porém não há relato na literatura de nefrite intersticial com uso de losartan. Descrevemos então, o caso de perda aguda de função renal após exposição a losartan, em paciente com dano renal prévio por nefropatia diabética, cuja biópsia renal diagnosticou nefrite intersticial aguda.

  11. Calcio sérico total y calcio corregido como predictores de severidad en pancreatitis aguda

    Directory of Open Access Journals (Sweden)

    A.A. Gutiérrez-Jiménez

    2014-01-01

    Conclusiones: El CT y CCA tomados en las primeras 24 h son útiles como predictores de severidad en pancreatitis aguda, con valores de S y predictivos comparables o superiores a los de las escalas pronósticas tradicionales.

  12. Benchmarking of FA2D/PARCS Code Package

    International Nuclear Information System (INIS)

    Grgic, D.; Jecmenica, R.; Pevec, D.

    2006-01-01

    FA2D/PARCS code package is used at Faculty of Electrical Engineering and Computing (FER), University of Zagreb, for static and dynamic reactor core analyses. It consists of two codes: FA2D and PARCS. FA2D is a multigroup two dimensional transport theory code for burn-up calculations based on collision probability method, developed at FER. It generates homogenised cross sections both of single pins and entire fuel assemblies. PARCS is an advanced nodal code developed at Purdue University for US NRC and it is based on neutron diffusion theory for three dimensional whole core static and dynamic calculations. It is modified at FER to enable internal 3D depletion calculation and usage of neutron cross section data in a format produced by FA2D and interface codes. The FA2D/PARCS code system has been validated on NPP Krsko operational data (Cycles 1 and 21). As we intend to use this code package for development of IRIS reactor loading patterns the first logical step was to validate the FA2D/PARCS code package on a set of IRIS benchmarks, starting from simple unit fuel cell, via fuel assembly, to full core benchmark. The IRIS 17x17 fuel with erbium burnable absorber was used in last full core benchmark. The results of modelling the IRIS full core benchmark using FA2D/PARCS code package have been compared with reference data showing the adequacy of FA2D/PARCS code package model for IRIS reactor core design.(author)

  13. Embolectomía en una embolia pulmonar aguda masiva

    Directory of Open Access Journals (Sweden)

    Manuel Carnero Alcázar

    2007-07-01

    Full Text Available Presentamos el caso de un varón de 57 años que, en el seno de un meningioma microcítico, padece una tromboembolia pulmonar masiva aguda con inestabilidad hemodinámica. Dado el riesgo de hemorragia por el tumor craneal, se contraindica la terapia fibrinolítica y se procede a practicar embolectomía pulmonar. Ésta se realiza bajo anestesia general, con canulación convencional y bajo hipotermia moderada. Se extrae émbolo en el tronco de la arteria pulmonar y con catéter de Fogarty se extraen émbolos en ramas lobares y segmentarias. Discutimos la asociación de enfermedad tromboembólica con determinadas neoplasias y el tratamiento de la tromboembolia pulmonar

  14. Epidemia de infección respiratoria aguda observaciones hospitalarias

    OpenAIRE

    Chavarría Milanés, José Fernando; Mata, Leonardo; Mohs Villalta, Edgar; Ramírez, Giselle; Lizano, Lucía

    1985-01-01

    artículo -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 1985 Se describe la clínica, tratamiento y complicaciones de 81 niños lactantes con infección respiratoria aguda. Los niños provenían del cantón central de San José y fueron admitidos en el Hospital Nacional de Niños del 10 de noviembre al 15 de diciembre de 1983. Se encontró un 57% de varones y un 43% de mujeres; los más afectados fueron los niños menores de 3 meses. Más de la mitad de los niños egresó con el di...

  15. Acidosis láctica severa y leucemia aguda

    Directory of Open Access Journals (Sweden)

    David Loja

    2004-03-01

    Full Text Available Reportamos el caso de una paciente de 27 años de edad con leucemia linfoblástica aguda, quien presentó acidosis láctica severa como complicación metabólica. Ella acudió con desnutrición severa, anemia marcada y síndrome consuntivo. No había compromiso del sistema reticuloendotelial y un mielograma inicial fue normal. Estos factores retardaron el diagnóstico y obligaron a ampliar el diagnóstico diferencial. La sospecha de neoplasia hematológica asociada a acidosis láctica sin causa aparente permitió reevaluar el caso con un nuevo mielograma y establecer el diagnóstico.

  16. Isquemia aguda de miembros inferiores secundaria a ergortismo

    Directory of Open Access Journals (Sweden)

    Franco J. Vallejo, MD

    2011-11-01

    Full Text Available Paciente de género femenino, de 21 años de edad, quien ingresó por dolor progresivo e intenso en miembros inferiores, y refirió antecedente reciente de ingestión de derivados del ergot. Al examen físico se observó ausencia de pulsos en ambos miembros inferiores. Por angiotomografia se documentó disminución severa, generalizada y bilateral, del calibre de los vasos arteriales de miembros inferiores. Se diagnosticó isquemia arterial aguda secundaria a ergotismo y se inició tratamiento con vasodilatadores y calcio-antagonistas, que resolvió los síntomas en su totalidad.

  17. Complicaciones de la apendicectomía por apendicitis aguda Complications of the appendicectomy due to acute appendicitis

    Directory of Open Access Journals (Sweden)

    Zenén Rodríguez Fernández

    2010-06-01

    Full Text Available INTRODUCCIÓN. La apendicectomía por apendicitis aguda es la operación de urgencia más común en los servicios quirúrgicos, pero no está exenta de complicaciones condicionadas por factores poco conocidos, cuya determinación podría disminuir la morbilidad y mortalidad por esta causa. Fue objetivo de esta investigación identificar algunos factores relacionados con la aparición de complicaciones en los pacientes apendicectomizados por apendicitis aguda. MÉTODOS. Se realizó un estudio descriptivo, observacional y prospectivo de 560 pacientes apendicectomizados, con diagnóstico histopatológico de apendicitis aguda, egresados del Servicio de Cirugía General del Hospital Provincial Docente «Saturnino Lora» de Santiago de Cuba durante el 2006. RESULTADOS. El 21,6 % de la serie sufrió algún tipo de complicación, principalmente la infección del sitio operatorio. Las complicaciones aumentaron en relación con la edad y se presentaron más frecuentemente en los pacientes con enfermedades asociadas, estado físico más precario, mayor tiempo de evolución preoperatoria, así como en las formas histopatológicas más avanzadas de la afección (en las que se incluyen los 4 pacientes fallecidos. La aparición de tales complicaciones puede ser causa de reintervenciones y de aumento de la estadía hospitalaria. CONCLUSIONES. El diagnóstico precoz de la enfermedad y la apendicectomía inmediata con una técnica quirúrgica adecuada previenen la aparición de complicaciones posquirúrgicas y determinan el éxito del único tratamiento eficaz contra la afección más común que causa el abdomen agudo, cuyo pronóstico depende en gran medida y entre otros factores, del tiempo de evolución preoperatoria y de la fase en que se encuentre el proceso morboso al realizar la intervención.INTRODUCTION. Appendicectomy due to acute appendicitis is the commonest urgency operation in surgical services but it is not exempt from complications conditions by

  18. Colesterol y triglicéridos como marcadores bioquímicos del estado de la enfermedad del paciente con leucemia linfocítica aguda

    Directory of Open Access Journals (Sweden)

    Marco Guzmán

    2004-12-01

    Full Text Available Objetivo: Determinar la relación de los niveles séricos de colesterol y triglicéridos con el estado de respuesta al tratamiento quimioterápico de inducción de pacientes con leucemia linfocítica aguda. Material y Métodos: La muestra la conforman 25 pacientes de 2 a 18 años de edad, admitidos al Instituto de Enfermedades Neoplásicas con un diagnóstico reciente de leucemia linfocítica aguda; determinándose en ellos sus concentraciones séricas de colesterol total, colesterol-HDL, colesterol-LDL y triglicéridos, antes y después de la primera fase de la quimioterapia de inducción. Resultados: Solamente 23 pacientes respondieron al tratamiento y en ellos observamos un incremento de 19,24 ± 4,49 mg/dL a 46,84 ± 15,38 mg/dL para el colesterol-HDL; y un descenso de 153,66 ± 36,39 mg/dL a 79,79 ± 34,53 mg/dL para los triglicéridos (p<0,0001. Por el contrario, en los pacientes que no respondieron al tratamiento, se obtuvo un incremento de 14,64 ± 2,46 mg/dL a 23,13 ± 14,23 mg/dL para el colesterol-HDL y un incremento de 121,88 ± 0,56 mg/dL a 161,01 ± 75,25 mg/dL para los triglicéridos. Conclusión: Las concentraciones séricas de colesterol y triglicéridos se relacionan con el estado de la enfermedad del paciente con leucemia linfocítica aguda. Proponemos a estos metabolitos, como marcadores bioquímicos en el seguimiento clínico de esta enfermedad.

  19. Impactos de adoecimento de longa duração: experiência de adultos jovens com Leucemia Mieloide Aguda

    Directory of Open Access Journals (Sweden)

    Reni Aparecida Barsaglini

    Full Text Available Resumo O presente artigo analisa os impactos materiais e imateriais imersos na experiência de adultos jovens com um adoecimento de longa duração – Leucemia Mieloide Aguda. Decorre de pesquisa mais ampla, inspirada na Fenomenologia de Alfred Schutz. Os dados foram obtidos por entrevistas em profundidade com quatro jovens, de 20 a 28 anos, em fase de manutenção no tratamento oncológico, entre novembro de 2013 a janeiro de 2014, em Mato Grosso. Os resultados enfocam aspectos marcantes dos impactos na experiência como o processo de descoberta da enfermidade em que o diagnóstico provocou sentimentos mobilizados por ideias sobre uma doença grave. Seguem-se os impactos na aparência devidos ao tratamento, sobressaindo a queda de cabelo e as estratégias cotidianas de enfrentamento, bem como o aumento ou a perda de peso. Por fim, é marcante o impacto da iminência da morte diante da letalidade da doença e o testemunho da ocorrência em pessoas conhecidas, colocando-a como possibilidade concreta para si, mas também como sobreviventes. Os impactos são os efeitos e as transformações na vida das pessoas e seu entorno e evocam (re ações, contudo, diluem-se na experiência compondo-a, e não sendo homogênea, sua abordagem privilegia a singularidade inscrita em biografias contextualizadas.

  20. Aprovechamiento del cambio de fase en la construcción

    OpenAIRE

    Domínguez Alonso, Manuel

    2011-01-01

    Nociones de transmisión de calor y de masa. Desfase y amortiguamiento. Los materiales de cambio de fase. Los materiales de cambio de fase en la construcción. Los materiales de cambio de fase en la climatización.

  1. Alterações do pericárdio na fase crônica da tripanossomíase cruzi humana e nas fases aguda e crônica da moléstia experimental

    Directory of Open Access Journals (Sweden)

    P. Raso

    1971-06-01

    Full Text Available Os Autores estudam as alterações do pericárdio, especialmente do pericárdio visceral na cardiopatia chagásica, confrontando-se com as alterações, observadas em outras cardiopatias (reumáticas e hipertensivas. Analisam as alterações pericárdicas no camundongo experimentalmente infectado e discutem especialmente a natureza e a gênese das lesões, a evolução e a correlação dos vários aspectos morfológicos entre si.

  2. Proteínas de fase aguda em cães: possíveis aplicações em cirurgia

    OpenAIRE

    Rubio, Camila Peres [UNESP; Schmidt, Elizabeth Moreira dos Santos [UNESP

    2014-01-01

    The acute phase proteins (APP) are blood proteins that change their serum concentrations in animals with infections, inflamations, trauma, surgery or stress. The magnitude of increase of the APP is related to the intensity of surgical trauma. The serum concentration of the APPs is directly proportional to the degree of tissue injury and/or inflammation. Therefore animals with postsurgical complications will have increasead concentrations of APPs. Thus, the APP concentrations may be an useful ...

  3. Termodinámica y diagramas de fase.

    Directory of Open Access Journals (Sweden)

    ANDRÉS FELIPE AGUDELO SANTAMARÍA

    2005-01-01

    Full Text Available Los diagramas de fase son la representación del equilibrio termodinámico de un sistema y permiten predecir las fases presentes y sus proporciones para unas condiciones determinadas. En este trabajo se plantea su fundamento termodinámico y se usa el modelo de solución ideal para obtener los diagramas de equilibrio líquido-sólido de algunos sistemas binarios, utilizando datos termodinámicos existentes en la literatura. Este modelo, aunque simple, permite una buena aproximación a algunos sistemas, y en general es una herramienta útil cuando se carece de datos experimentales. Aunque los diagramas de equilibrio son de gran utilidad en la práctica ingenieril, en la práctica pocos sistemas exhiben comportamiento ideal, ya que esto requiere mucha semejanza entre los componentes.

  4. Operação Liberdade Duradoura: A Segunda Fase?

    Directory of Open Access Journals (Sweden)

    Cristina Soreanu Pecequilo

    2011-09-01

    Full Text Available O presente artigo tem como tema as recentes afirmações por parte dos EUA e seus aliados com relação à instauração da segunda fase da Operação Liberdade Duradoura e dos impactos que essa terá para a atual política de combate ao terrorismo e de para a ocupação do Afeganistão.

  5. La faïence de Nevers (1585-1900

    Directory of Open Access Journals (Sweden)

    Jean Rosen

    2010-10-01

    Full Text Available Depuis 1585, et sans solution de continuité jusqu’à nos jours, Nevers, aussi bien par son importance historique que par le nombre de ses manufactures – douze en 1755, plus de trente ateliers en tout –, a joué un rôle de tout premier plan dans la propagation et l’évolution de la faïence française, du xvie au xxe siècle, et peut être considéré comme le centre idéal pour une recherche sur le long terme. Si la faïence de Nevers a déjà été abordée de multiples façons dans divers colloques et exp...

  6. Insuficiencia renal aguda obstructiva: Estudio de 42 pacientes

    Directory of Open Access Journals (Sweden)

    Isabel Caravia Pubillones

    1997-04-01

    Full Text Available Se revisaron las historias clínicas de 42 pacientes ingresados en el Servicio de Cuidados Intensivos del Instituto de Nefrología con el diagnóstico de insuficiencia renal aguda obstructiva (IRAO, con 1 ó 2 riñones funcionantes. Los pacientes estudiados estaban entre la 5ta y la 7ma década de la vida, con una mayor incidencia en el sexo masculino. La causa más frecuente de IRAO fue la litiasis renal (47,62 %, seguida por las enfermedades tumorales que infiltraban los uréteres (28,57 %. Se empleó tratamiento médico en 9 pacientes y el resto (33 fueron sometidos a tratamiento quirúrgico. Las principales complicaciones fueron sépticas con un franco predominio de las infecciones del tractus urinario (38,5 %. Hubo 3 fallecidos, 2 de ellos por complicaciones cardiovasculares. Del total de insuficiencias renales agudas que se atendieron en nuestro Centro, el 10,6 % correspondió a IRAO. La efectividad del tratamiento quirúrgico empleado fue del 94,4 % de curación en los pacientes atendidosMedical records of 42 patients admitted to the Intensive Care Unit of the Institute of Nephrology diagnosed as having acute obstructive renal failure with 1 or 2 kidneys functioning, were revised. Patients studied ware at the 5th and 7th decade of life with a greater incidence in males. The most frequent cause of acute obstructive renal failure was renal lithiasis (47.62 %, followed by tumor diseases which were infiltrating the ureters (28.57 %. Medical treatment was employed in 9 patients and the remaining (33 were submitted to surgical treatment. The main complications were septic with predominance of urinary tract infections (38.5 %. Three patients died, 2 of them as a result of cardiovascular complications. Of the total number of cases presenting with acute renal failure and treated in our center, 10.6 % had an acute obstructive renal failure. The effectiveness of the surgical treatment performed was 94.4 % of healing in patients treated for this

  7. FRACCIONAMIENTO DE CONTAMINANTES ORGÁNICOS PERSISTENTES EN AIRE URBANO DE MADRID: FASE GAS Y FASE PARTICULADA

    Directory of Open Access Journals (Sweden)

    Beatriz Barbas

    2014-01-01

    Full Text Available En el presente trabajo se evaluó la presencia de algunos Contaminantes Orgánicos Persistentes (COP en muestras de aire de la ciudad de Madrid (España, discriminando entre la fase gas (FG y la materia particulada en suspensión (MPS. Para ello se utilizaron captadores activos de alto volumen (CAV equipados con espumas de poliuretano y filtros de microfibra de vidrio. Los policlorobifenilos resultaron los contaminantes mayoritarios (104.6 ± 86.6 pg/Nm3, media ± desviación estándar, seguidos de polibromodifenil éteres (20.4 ± 11.6 pg/Nm3, declorane plus (0.8 ± 0.5 pg/Nm3 y finalmente policlorodibenzo-p-dioxinas y policlorodibenzofuranos (0.3 ± 0.1 pg/Nm3. Los resultados, en concordancia con los obtenidos en otras ciudades, no sólo confirman la presencia de COP en el aire de Madrid, sino que evidencian diferencias importantes en cuanto al fraccionamiento (presencia mayoritaria en la fase gas o en la fase particulada entre los distintos analitos y congéneres evaluados.

  8. Linfonodo pulmonar na paracoccidioidomicose aguda infantil (relato de um caso

    Directory of Open Access Journals (Sweden)

    Evanil Pires de Campos

    1992-09-01

    Full Text Available Observou-se a evolução de um linfonodo pulmonar na paracoccidioidomicose (PCM aguda infantil. Doente, masculino, 6 anos, branco, natural de Curitiba (PR, procedente de Guaratinguetá (SP, que há 3 meses desenvolveu quadro gripal, febre diária, bimodal, prolongada, precedida de calafrio, acompanhada de sudorese inodora, cefaléia frontal e anorexia. Diagnosticado e tratado como pneumonia por cinco dias, sem melhora do quadro. Há 2 meses, apresentou dor óssea nos braços e articulações do pé, com edema inflamatório e emagrecimento de 6 kg em 3 meses. Exame físico revelou: peso 20 kg; estatura 120 cm; P. A. 90/60 mmHg; facies atípica, hipoativo, palidez cutâneo-mucosa (+ +, hipotrofia muscular, adenopatiageneralizada, sopro sistólico suave em foco aórtico acessório e hepatesplenomegalia. Imunodifusão com exoantígeno glicoprotéico 43 kdpositiva (1/32. A biópsia de gânglio revelou Paracoccidioides brasiliensis. A radiologia demonstrou na primeira consulta, discreto infiltrado intersticial bilateral com linfoadenomegaliapara-hilar que desaparecu em 30 dias. Observou- se, ainda, massa tumoral mediastínica superior, hiperplasia do sistema fagocítico mononuclear e lesões osteolíticas nos 60 dias iniciais da evolução.

  9. Efeito da hipertermia na pancreatite aguda grave experimental

    Directory of Open Access Journals (Sweden)

    Maurício Gustavo Ieri Yamanari

    Full Text Available OBJETIVO: O objetivo deste estudo é avaliar os efeitos da hipertermia na pancreatite aguda (PA grave experimental induzida por ácido taurocólico. MÉTODO: A PA grave foi induzida pela injeção retrógrada de ácido taurocólico a 2,5% ou 5% no ducto pancreático principal. Após a indução, os animais foram colocados numa gaiola contendo duas lâmpadas de 100 W. A temperatura corporal foi aumentada para 39,5ºC e mantida neste nível por 45 minutos. Foram estudados taxa de mortalidade em 72 horas, permeabilidade vascular no pâncreas, porcentagem de água no tecido pancreático, amilase sérica, histologia (edema, necrose acinar e infiltrado inflamatório e níveis séricos de IL-6 e IL-10. RESULTADOS: Não houve alteração em nenhum dos parâmetros avaliados. CONCLUSÃO: Não há benefício da hipertermia na PA grave experimental induzida por ácido taurocólico.

  10. Otitis media aguda: nuevo enfoque terapéutico

    Directory of Open Access Journals (Sweden)

    Ileana Alvarez Lam

    2004-03-01

    Full Text Available La otitis media aguda continúa siendo una de las enfermedades infecciosas más frecuentes en la infancia. Se hace una revisión del tema haciendo énfasis en la conducta terapéutica actual luego del surgimiento de complejos mecanismos de resistencia bacteriana creados por los microorganismos causantes de la enfermedad. Como toda enfermedad infecciosa las esperanzas están cifradas en el surgimiento de una vacuna que impacte de forma positiva en nuestra población infantil. En tal sentido se hace una reflexión sobre el uso de la vacuna antineumocócica de 7 valencias (Prevnar y su repercusión sobre esta enfermedad.Acute otitis media is still one of the most common infectious diseases among children. A review of the topic is made giving emphasis to the present therapeutic conduct after the appearance of complex mechanisms of bacterial resistance created by the microorganisms causing the disease. As in every infectious disease, we place our hopes on the emergence of a vaccine with a positive impact on our infantile population. In this sense, a reflection is made on the use of the heptavalent antipneumococcic vaccine (Prevnar and its repercussion on this disease.

  11. Eficácia e tolerância do nitrofurfurilidene (1 na fase crônica da Moléstia de Chagas

    Directory of Open Access Journals (Sweden)

    Newton Neves da Silva

    1974-12-01

    Full Text Available Foram selecionados 25 pacientes chagásicos crônicos que apresentavam sorologia positiva e elevada parasitemia. A 15 deles, durante 120 dias, foi ministrado o Nitrofurfurilidene na dose diária de 8 a 10 mg por quilo de peso. Aos 10 restantes deu-se placebo. No trans e pós-tratamento não se verificaram alterações nas funções hepática, hematopoiética ou renal de caráter iatrogênico. Xenodiagnóstico e provas sorológicas foram realizadas mensalmente. O xenodiagnóstico, nos 15 doentes tratados, aos 60º dias da fase trans-terapêutica, mostrou-se negativo e assim se manteve durante 4 anos, período de tempo que durou a nossa observação. Quanto às reações sorodiagnósticas o mesmo não ocorreu, embora a partir dos 12 meses do término do tratamento o grupo que recebeu a droga tenha passado a apresentar níveis mais baixos de anticorpos. Os A.A. comentam o desacordo entre os achados do xenodiagnóstico e os das provas sorológicas e sugerem uma hipótese para justificá-lo. Concluem que, embora com menos evidência do que nas formas agudas, o Nitrofurfurilidene revela certa eficácia na fase crônica da infecção chagásica.

  12. Pengaruh pengolahan terhadap Pati Resisten Pisang Kepok (Musa paradisiaca fa. typica) dan Pisang Tanduk (Musa paradisiaca fa. corniculata)

    OpenAIRE

    Marsono, Yustinus

    2016-01-01

    A study on the effect processing on resistant starch (RS) content and chemical composition of kepok (Musa paradisiaca fa. typica) and tanduk banana (Musa paradisiaca fa. corniculata) has been conducted. Mature banana was steamed, steamed - cooled, steamed - frozen, dried and dried - fried and was analyzed for starch, RS, simple sugars and chemical composition. RS content was determined by enzymatic method. It was found that steaming chaned RS from 6.2 mg/g to 9.5 mg/g (53%) for kepok banana a...

  13. checkCIF/PLATON report Datablock: fa083

    Indian Academy of Sciences (India)

    checkCIF/PLATON report. Structure factors have been supplied for datablock(s) fa083. THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors ...

  14. checkCIF/PLATON report Datablock: fa289

    Indian Academy of Sciences (India)

    THIS REPORT IS FOR GUIDANCE ONLY. IF USED AS PART OF A REVIEW PROCEDURE. FOR PUBLICATION, IT SHOULD NOT REPLACE THE EXPERTISE OF AN EXPERIENCED. CRYSTALLOGRAPHIC REFEREE. No syntax errors found. CIF dictionary Interpreting this report. Datablock: fa289. Bond precision:.

  15. Molecular basis of Acute Myelogenous Leukemia As bases moleculares da leucemia mielóide aguda

    Directory of Open Access Journals (Sweden)

    Eduardo M. Rego

    2002-01-01

    Full Text Available Acute Myelogenous Leukemia (AML is frequently associated with recurring chromosomal translocations, which lead to the fusion of two genes encoding transcription factors. As the moieties of these fusion proteins retain part of the functional domains of the wild-type proteins, they may interfere directly or indirectly with the transcriptional regulation of the leukemic cell, conferring survival advantage. The majority of the transcription factors commonly involved in recurring chromosomal translocations may be grouped in one of the following families: core binding factor (CBF, retinoic acid receptor alpha (RARalpha, homeobox (HOX family, and mixed lineage leukemia (MLL. In vivo analysis of the molecular basis of leukemogenesis through the generation of transgenic mouse models revealed that a common theme is the recruitment of transcriptional co-activators and co-repressors by these fusion proteins. However, the expression of the fusion protein is not sufficient to induce full blown leukemia, as evidenced in part by the long latencies required for disease development in the transgenic models of leukemia, and therefore, second mutagenic events may contribute to AML pathogenesis.A leucemia mielóide aguda (LMA está freqüentemente associada a translocações cromossômicas recorrentes. Em muitos casos, os genes presentes nos pontos de quebra cromossômica são conhecidos e, quase todos codificam para fatores de transcrição. O gene híbrido, resultante da justaposição de exons de genes distintos, codifica para proteínas de fusão. Como estas retêm a maior parte dos domínios funcionais das proteínas selvagens, elas interferem direta ou indiretamente com regulação da transcrição gênica, conferindo vantagem à sobrevivência das células leucêmicas. A maioria dos fatores de transcrição afetados pelas translocações cromossômicas associadas a LMA pode ser agrupada numa das seguintes famílias: dos core binding factors (CBF, do receptor

  16. Disruption of the FA/BRCA pathway in bladder cancer.

    Science.gov (United States)

    Neveling, K; Kalb, R; Florl, A R; Herterich, S; Friedl, R; Hoehn, H; Hader, C; Hartmann, F H; Nanda, I; Steinlein, C; Schmid, M; Tonnies, H; Hurst, C D; Knowles, M A; Hanenberg, H; Schulz, W A; Schindler, D

    2007-01-01

    Bladder carcinomas frequently show extensive deletions of chromosomes 9p and/or 9q, potentially including the loci of the Fanconi anemia (FA) genes FANCC and FANCG. FA is a rare recessive disease due to defects in anyone of 13 FANC genes manifesting with genetic instability and increased risk of neoplasia. FA cells are hypersensitive towards DNA crosslinking agents such as mitomycin C and cisplatin that are commonly employed in the chemotherapy of bladder cancers. These observations suggest the possibility of disruption of the FA/BRCA DNA repair pathway in bladder tumors. However, mutations in FANCC or FANCG could not be detected in any of 23 bladder carcinoma cell lines and ten surgical tumor specimens by LOH analysis or by FANCD2 immunoblotting assessing proficiency of the pathway. Only a single cell line, BFTC909, proved defective for FANCD2 monoubiquitination and was highly sensitive towards mitomycin C. This increased sensitivity was restored specifically by transfer of the FANCF gene. Sequencing of FANCF in BFTC909 failed to identify mutations, but methylation of cytosine residues in the FANCF promoter region was demonstrated by methylation-specific PCR, HpaII restriction and bisulfite DNA sequencing. Methylation-specific PCR uncovered only a single instance of FANCF promoter hypermethylation in surgical specimens of further 41 bladder carcinomas. These low proportions suggest that in contrast to other types of tumors silencing of FANCF is a rare event in bladder cancer and that an intact FA/BRCA pathway might be advantageous for tumor progression. Copyright (c) 2007 S. Karger AG, Basel.

  17. Lúpus eritematoso sistêmico e pancreatite aguda: relato de dois casos

    OpenAIRE

    Azevedo, Ana Beatriz Cordeiro de; Brito, Fabiano Almeida; Santos, Flávia Patrícia Sena Teixeira; Ferreira, Gilda Aparecida; Carvalho, Marco Antônio Parreiras de

    2003-01-01

    A pancreatite aguda é uma manifestação incomum do lúpus eritematoso sistêmico (LES) e a freqüência desta associação não é conhecida. Contudo, a pancreatite aguda é um diagnóstico diferencial importante na avaliação da dor abdominal em pacientes com LES. Os pacientes, normalmente, apresentam dor de intensidade variável, algumas vezes simulando abdome agudo. Vários fatores têm sido implicados na patogênese desta condição, tais como fenômenos autoimunes, vasculite, anticorpos antifosfolípides e ...

  18. Abdomen agudo ocasionado por apendicitis aguda de probable origen tuberculoso. Informe de un caso

    OpenAIRE

    Montiel-Jarquín, Álvaro José; Alvarado-Ortega, Iván; Romero-Figueroa, María del Socorro; Rodríguez-Pérez, Fabiola; Rodríguez-Lima, Felipe; Loria-Castellanos, Jorge

    2017-01-01

    RESUMEN Antecedentes: la apendicitis aguda tuberculosa es una enfermedad rara, constituye de 0,001 % a 0,01 % de las formas clínicas de tuberculosis. Se presenta un caso de apendicitis aguda probablemente tuberculosa como causa de abdomen agudo quirúrgico. Caso clínico: hombre de 29 años con cuadro de dolor abdominal leve a moderado que se intensificó y localizó en el hemiabdomen derecho, claudicación, febrícula, vómito, mal estado general, leucocitosis de 11 300/µL y neutrofilia de 91 %....

  19. Ensaios clínicos toxicológicos, fase I, de um fitoterápico composto (Schinus terebinthifolius Raddi, Plectranthus amboinicus Lour e Eucalyptus globulus Labill

    Directory of Open Access Journals (Sweden)

    Patrícia Trindade C. Paulo

    Full Text Available Neste estudo, foram realizados ensaios clínicos toxicológicos, fase I, do produto fitoterápico composto pelas plantas medicinais Schinus terebinthifolius Raddi, Plectranthus amboinicus Lour e Eucalyptus globulus Labill. O estudo foi realizado no Hospital Universitário Lauro Wanderley/UFPB/PB e, para isto, foram selecionados 28 voluntários sadios, sendo 14 homens e 14 mulheres que ingeriram por via oral, ininterruptamente durante 8 semanas, 15 mL do produto, três vezes ao dia; e no 3º e 7º dia, 3ª e 6ª semanas e 24 h após a 8ª semana, foram feitas avaliações clínicas e laboratoriais para análise da toxicidade aguda e crônica. Os resultados obtidos demonstraram que os pacientes não apresentaram alterações clínicas, laboratoriais e reações adversas significantes, apenas pequenas alterações foram detectadas no sangue através da aspartato transaminase (AST e fosfatase alcalina no grupo feminino para um p < 0,05; no entanto, estes valores determinados permaneceram dentro dos valores de normalidade para indivíduos adultos. Conclui-se que estes dados, em complementação àqueles obtidos com os estudos pré-clínicos, confirmam a baixa toxicidade do produto fitoterápico.

  20. Injúria renal aguda: um alerta global

    Directory of Open Access Journals (Sweden)

    Philip Kam Tao Li

    2013-03-01

    Full Text Available A Injúria Renal Aguda (IRA é cada vez mais prevalente nos países desenvolvidos e nos em desenvolvimento, e está associada com morbidade e mortalidade severas. A maioria das causas da IRA pode ser evitada por meio de intervenções em nível individual, comunitário, regional e intra-hospitalar. Medidas efetivas devem incluir, em toda a comunidade, os esforços para aumentar a consciência dos efeitos devastadores do IRA e fornecer orientações sobre as estratégias de prevenção, bem como o reconhecimento e tratamento precoces. Os esforços devem ser focados em minimizar as causas de IRA, aumentando a consciência da importância de medidas seriadas de creatinina sérica em pacientes de alto risco para IRA, e documentar o volume de urina em pessoas gravemente doentes para obtenção de diagnóstico precoce; até o momento, não há ainda um papel definitivo para outros biomarcadores. Há a necessidade de protocolos para sistematizar a conduta em condições de IRA pré-renal e em infecções específicas. Dados mais precisos sobre a verdadeira incidência e o impacto clínico da IRA ajudarão a melhor conhecer a importância desta doença, a aumentar o conhecimento de IRA por parte dos governantes, dos médicos em geral e de outros profissionais de saúde para ajudar na prevenção da doença. A prevenção é a chave para evitar a pesado ônus de mortalidade e morbidade associada com IRA.

  1. Intoxicación aguda por hidrato de hidracina

    Directory of Open Access Journals (Sweden)

    Santiago Nogué Xarau

    2008-06-01

    Full Text Available Se aporta un caso de exposición aguda, debido a un vertido accidental de unos 25 litros de hidrato de hidracina, que el trabajador estuvo recogiendo sin ningún tipo de equipo de protección individual. El trabajador presentó alteraciones bucales, cutáneas y dolores abdominales difusos. De las pruebas complementarias únicamente se detectó un aumento de la bilirrubina total con predominio de la indirecta. Se le separó de la exposición, se le administró un tratamiento sintomático y en un periodo de un mes se recuperó íntegramente. Se comenta los principales casos de intoxicación por hidracina descritos en la literatura médica y se enfatiza en las medidas preventivas que se deben tomar para evitar casos como éste.We report a case of poisoning by acute exposure to hydrazine hydrate in a worker clearing up an accidental spillage of about 25 litres of the product who had no type of individual protective equipment. The patient presented buccal and cutaneous involvement and diffuse abdominal pain. Complementary tests were unremarkable except for an increase in total bilirubin with a predominance of indirect bilirubin. The patient was removed from the occupational exposure, symptomatic treatment was administered and the patient recovered completely after one month. We review the main reported cases of hydrazine poisoning and emphasize the preventive measures that should be taken to avoid this type of poisoning.

  2. Dacriocistitis aguda neonatal (1996-2005 Acute neonatal dacryocystitis

    Directory of Open Access Journals (Sweden)

    Zoila del S López Díaz

    2006-12-01

    Full Text Available Se realizó un estudio longitudinal y retrospectivo en diez años (1996-2005, de todos los neonatos cuyo motivo de ingreso en nuestra Unidad de Cuidados Intensivos Neonatales fue ser portadores de dacriocistitis aguda. Se obtuvo los siguientes resultados: incidencia 0,04 c/ 100 ingresos. Predominio: edades entre 7-27días (sepsis tardía, sexo femenino 66,6 %, nacidos de embarazos a término y con buen peso al nacer 100 %. Etiología no precisada 83,3 %. Tratamiento utilizado: antibioticoterapia (penicilina + gentacina, 4 pacientes, 66,6 %, (unasyn, 1 paciente, 16,6 %, (amoxicilina + unasyn + gentamicina, 1 paciente, 16,6 %; uso de inmunoglobulina humana en 2 pacientes. Complicaciones: celulitis facial y periorbitaria 66,6 %; absceso periorbitario 33,3 %; fiebre (33,3 % y obstrucción nasal 16,6 %. Evolución satisfactoria con seguimiento por Oftalmología después del egreso hospitalario, en 100 % de los casosA retrospective longitudinal study of all neonates admitted to our Intensive Care Unit because they suffered from acute dacryocystitis was performed for 10 years (1996-2005. The results were as follows: incidence rate of 0,04 per 100 admissions; prevalence: 7-27d age groups (late sepsis, females with 66,6%; neonates born to term pregnancies and with good birthweight in 100%. Inaccurate etiology in 83,3 %. Treatment: antibiotic therapy (penicilline + gentamycin in 4 paients, 66,6%, (unasyn, one patient, 16,6 %, (amoxycillin + unasyn +gentamycin, 1 patient, 16.6 %. Use of human immunoglobulin in 2 patients. Complications: facial and periorbital cellulitis, 66,6%; periorbital abscess 33,3 %; fever (33,3 % and nasal obstruction (16,6 %. Satisfactory recovery with ophtalmological follow-up after discharge from hospital in 100 % of cases

  3. Intoxicação aguda por cobre em ovinos

    Directory of Open Access Journals (Sweden)

    Marcele Bettim Bandinelli

    2013-10-01

    Full Text Available Descrevem-se casos de intoxicação aguda por cobre em ovinos da raça Santa Inês, numa propriedade rural, no Rio Grande do Sul. Três ovelhas recém-paridas, que consumiam ração formulada para bovinos, ingeriram, avidamente, sal mineral comercial para bovinos e apresentaram doença clínica e morte, uma semana após a introdução do sal. Os animais desenvolveram anorexia, permaneceram em decúbito lateral, o qual evoluiu para esternal e apresentaram fasciculação e rigidez muscular generalizada, antes de morrerem. À necropsia de um desses animais, as principais alterações foram hepatomegalia moderada e acentuação do padrão lobular hepático, além de erosões e ulcerações multifocais aleatórias na mucosa abomasal. Na avaliação histológica do fígado, havia necrose hepatocelular centrolobular acentuada e difusa, tumefação de hepatócitos, predominantemente, na região periportal, além de pequena quantidade de células de Kupffer com pigmento granular citoplasmático. O diagnóstico baseou-se na história clínica, nos achados de necropsia e histopatológicos e confirmou-se pelas altas concentrações de cobre detectadas no tecido hepático e nas amostras de ração e sal mineral.

  4. Uso de antimicrobianos en la enfermedad diarreica aguda

    Directory of Open Access Journals (Sweden)

    Enrique A. González Corona

    1996-04-01

    Full Text Available Se realizó un estudio sobre el estado actual del uso de antimicrobianos en el Servicio de Enfermedades Diarreicas Agudas del Hospital Infantil Docente Sur de Santiago de Cuba, durante el período comprendido entre marzo y agosto de 1992. El universo estuvo integrado por 427 pacientes ingresados, de los cuales sólo 13,1 % requirió el empleo de estos medicamentos: 9,4 % por infección enteral y 3,7 % por extraenteral bacteriana. Más de la tercera parte de los afectados curaron con alimentación continuada y rehidratación, en su mayoría oral, y fueron las diarreas persistentes y disentéricas las que más frecuentemente condicionaron su administración. El criterio clínico fue determinante en su indicación.A study was carried out on the current state of the use of microbicidals in the Acute Diarrhea Service of the Southern Educational Children's Hospital at Santiago de Cuba, during the period between March and August 1992. The universe was integrated by 427 inpatients, of which only the 13,1 % required the use of these drugs: 9,4 % due to enteral infection, and 3,7 % due to bacterial extraenteral infection. More than the third part of the patients healed with continuous feeding and rehydration, mostly oral, and the persistent and dysenteric diarrheas conditioned most frequently its administration. The clinical criterion was determining in its indication.

  5. Problemas identificados en el manejo de la enfermedad diarreica aguda

    Directory of Open Access Journals (Sweden)

    Carlos Coronel Carbajal

    2000-08-01

    Full Text Available Se realizó un estudio retrospectivo de corte transversal en el Hospital "Armando E. Cardoso", en el período de 1 año (Mayo 98-Febrero 99. Este estudio consistió en encuestar a 256 madres de niños con diarreas agudas con el objetivo de identificar las costumbres inapropiadas que aún persisten en el manejo ambulatorio de las enfermedades diarreicas. Al concluir el estudio se pudo apreciar cómo en el 56,3 % de los pacientes hubo mal manejo alimentario, además solo el 12,1 % de las madres buscaron orientación médica en las primeras 24 horas. En este estudio se pudo conocer que el 100 % de las madres saben que las soluciones de rehidratación oral (SRO forman parte del tratamiento de la EDA, pero solo el 42 % conoce que previenen la deshidratación, además solo un 25 % conoce de otros líquidos que reemplazan el uso de las soluciones de rehidratación oralA cross-sectional study was conducted at the "Armando E. Cardoso" Hospital from May, 1998, to February,1999. 256 mothers of children with acute diarrhea were surveyed in order to identify the inappropiate costums that still exist in the ambulatory management of diarrheal diseases. A poor food management was observed in 56.3% of the patients and only 12.1% of the mothers looked for medical advice during the first 24 hours. It was possible to know through this study that 100% of the mothers know that oral rehydration solutions (ORS are part of the treatment of ADD, but only 42% know that the drug also prevents dehydration. Just 25% know about other fluids that replace the use of oral rehydration solutions

  6. Regulation of palmitoyl-CoA chain elongation by clofibric acid in the liver of Zucker fa/fa rats.

    Science.gov (United States)

    Toyama, Tomoaki; Kudo, Naomi; Mitsumoto, Atsushi; Kawashima, Yoichi

    2005-05-01

    The regulation of palmitoyl-CoA chain elongation (PCE) by clofibric acid [2-(4-chlorophenoxy)-2-methylpropionic acid] was investigated in comparison with stearoyl-CoA desaturase (SCD) in the liver of obese Zucker fa/fa rats. The proportion of oleic acid in the hepatic lipids of Zucker obese rats is 2.7 times higher than that of lean littermates. The activities of PCE and SCD in the liver of Zucker obese rats were markedly higher than in lean rats, and the hepatic uptake of 2-deoxyglucose (2-DG) was also higher in Zucker obese rats compared with lean rats. The increased activities of SCD and PCE in Zucker obese rats were due to the enhanced expression of mRNA of both SCD1 and rat FA elongase 2 (rELO2), but not SCD2 or rELO1. The proportion of oleic acid in the liver was significantly increased by the administration of clofibric acid to Zucker obese rats, and the hepatic PCE activity and rELO2 mRNA expression, but not the SCD activity or SCD1 mRNA expression, were increased in response to clofibric acid treatment. By contrast, the activities of both PCE and SCD and the mRNA expression of SCD1 and rELO2 in the liver were increased by the treatment of Zucker lean rats with clofibric acid. Multiple regression analysis, which was performed to determine the relationships involving PCE activity, SCD activity, and the proportion of oleic acid, revealed that the three parameters were significantly correlated and that the standardized partial regression coefficient of PCE was higher than that of SCD. These results indicate that oleic acid is synthesized by the concerted action of PCE and SCD and that PCE plays a crucial role in the formation of oleic acid when Zucker fa/fa rats are given clofibric acid.

  7. Metformin ameliorates diabetes but does not normalize the decreased GLUT 4 content in skeletal muscle of obese (fa/fa) Zucker rats

    DEFF Research Database (Denmark)

    Handberg, A; Kayser, L; Høyer, P E

    1993-01-01

    We studied the expression of the glucose transporter GLUT 4 in the soleus and red gastrocnemius muscles from obese, diabetic (fa/fa) Zucker rats compared to their lean littermates (Fa/-), with and without treatment with the antidiabetic drug metformin. In the untreated groups of rats, the GLUT 4...... content in a crude membrane fraction of both the soleus and the red gastrocnemius muscles were significantly lower in the obese (fa/fa) rats (3.46 +/- 0.28 vs. 6.04 +/- 0.41, p ... the same rats were confirmed by quantitative immunofluorescence microscopy, and the results were significantly correlated with the results obtained from quantitative immunoblotting (rho = 0.70, p fa/fa rats could contribute to the well-established insulin...

  8. Measurement of CSF volume with 3D-FASE MRI

    International Nuclear Information System (INIS)

    Kanayama, Shoichi; Calderon, A.; Makita, Jun-ichi; Ohara, Yukou; Tsunoda, Akira; Sato, Kiyoshi.

    1997-01-01

    A noninvasive and fast cerebrospinal fluid (CSF) volume measurement method has been developed using 3D-FASE MRI and a semi-automatic segmentation process. Images with a high CSF/(gray and white matter) ratio (about 10-20) were obtained with a heavily T 2 weighted 3D-FASE sequence. The CSF region was segmented with a region growing method and the volume was calculated from the number of segmented voxels with a signal intensity weighted summation. Total measurement time was about 30 minutes for each study. The errors of the measured volumes were within 10% for the phantom experiments. Intracranial CSF volumes of normal volunteers ranged between about 100 and 200 cc and the ventricle/intracranial CSF ratio was about 10%. 3D display of the segmented intracranial and ventricle CSF regions was also carried out and proved to be useful to understand the anatomy. Increased intracranial and/or ventricle CSF volumes were obtained for a hydrocephalic patient and one patient with probable cerebral atrophy. The results suggest that the developed method could be used for the diagnosis of patients with neurological diseases. (author)

  9. Penerapan Perencanaan Pajak Penghasilan pada Fa Trico Paint Factory

    Directory of Open Access Journals (Sweden)

    Stefanus Ariyanto

    2011-05-01

    Full Text Available The most important parts of government income comes from taxes, especially income taxes. The different point of view arises between government and tax payer. While the government try to increase the tax income, the taxpayers always intend to minimize their tax burden by implementing tax management/plannning. This paper is a case study in FA Trico Paint Factory (FA TPF that try to reperforming company’s income tax return preparation with the main purpose to minimize company tax burden, while it is still comply with tax regulations in Indonesia. This approach could be an alternative for the company to restate it’s annual income tax return, to avoic fines and charges for not comply with the regulations, and minimize it’s income tax expense by approximately 10% per year. 

  10. Choosing the governing solutions for FA of AES-2006

    International Nuclear Information System (INIS)

    Vasilchenko, I.; Dragunov, Y.; Ryzhov, S.; Kobelev, S.; Vyalitsyn, V.; Troyanov, V.

    2008-01-01

    According to the program approved by the Government of Russia the AES-2006 design intended as a base one for the beginning of realization of the plans on development of the nuclear power engineering of Russia in the near future has been under way now. The most crucial components of the reactor plant are certainly the core and its basic component - FA. In the FA design such factors are concentrated that mainly define safety, profitability, adaptability to manufacture and operation of the fuel and NPP as a whole. As the nearest prototype for AES-2006 the TVS-2M design used at the Balakovo NPP is taken. The report shows on the basis of qualitative and quantitative evaluation that design of TVS-2 and its modifications TVS-2M are in the best compliance with the requirements of the project of the new RP AES-2006. This compliance is confirmed by the operational experience of the basic variant of the design

  11. Pneumonia eosinofílica aguda com evolução para síndroma de dificuldade respiratória aguda: caso clínico

    OpenAIRE

    J.P.F. Baptista; P.C. Casanova; J.P.A. Sousa; P.J. Martins; A. Simões; V. Fernandes; J. Souto; J.J. Costa; A. Rebelo; L. Carvalho; J. Pimentel

    2004-01-01

    RESUMO: Os autores apresentam um caso de pneumonia eosinofílica aguda (PEA) associada a síndroma de dificuldade respiratória aguda grave num adolescente previamente saudável, medicado com nitrofurantoína. A PEA deve ser incluída no diagnóstico diferencial da pneumonia adquirida na comunidade, bem como na lista das patologias causadoras de síndroma de dificuldade respiratória aguda, e o seu diagnóstico deve ser sugerido pela presença de alveolite eosinofílica no líquido de lavagem broncoalveol...

  12. Estudio molecular del gen MLL en 30 pacientes con leucemias agudas Molecular study of MLL gen in 30 patients with acute leukemias

    Directory of Open Access Journals (Sweden)

    Raquel Levón Herrera

    2000-04-01

    Full Text Available Los reordenamientos del gen MLL en la banda cromosómica 11q23 son frecuentes en leucemias agudas (LA en niños y en las LA secundarias desarrolladas después de la terapia con inhibidores de la enzima topoisomerasa II. En menor medida también se aprecia en adultos con LA. La presencia de estos reordenamientos se considera un indicador de mal pronóstico asociado con resultados clínicos desfavorables, por ello es muy importante realizar su determinación en las LA. En este trabajo mostramos los resultados preliminares de la introducción del estudio del gen MLL en nuestro país mediante la técnica de Southern. Analizamos ADN de 30 pacientes con LA, incluidos niños y adultos, que en el momento del estudio se encontraban al debut o en recaída. El estudio molecular se realizó con la sonda FA4, que es un inserto genómico del gen MLL. Sólo uno de los 30 pacientes mostró bandas de reordenamiento con 2 enzimas de restricción diferentes, el resto mostró el gen MLL en configuración germinal. Es interesante destacar que el paciente con el reordenamiento era un niño con leucemia mieloblástica aguda subtipo M5b, lo cual concuerda con la literatura, donde se describe que estos reordenamientos están estrechamente correlacionados con los subtipos mielomonocítico (M4 y monocítico (M5 de leucemia mieloide aguda (LMARearrangements of MLL gen in llq23 chromosomal band are frequents in childhood type of acute leukemia (AL and in secondary AL, developed after therapy with II topoisomerase enzyme. To a lesser extent also is seen in adults with AL. Presence of theses rearrangements is considered to be a worse prognosis indicator, associated with unfavourable clinical results, that is why it is very important to carry our its assessment in AL. In this paper authors present preliminary results from introduction of study on MLL gen in our country through Southern technique. DNA from 30 patients was analized, including children and adults, that at the

  13. A protein prioritization approach tailored for the FA/BRCA pathway.

    Directory of Open Access Journals (Sweden)

    Anneke Haitjema

    Full Text Available Fanconi anemia (FA is a heterogeneous recessive disorder associated with a markedly elevated risk to develop cancer. To date sixteen FA genes have been identified, three of which predispose heterozygous mutation carriers to breast cancer. The FA proteins work together in a genome maintenance pathway, the so-called FA/BRCA pathway which is important during the S phase of the cell cycle. Since not all FA patients can be linked to (one of the sixteen known complementation groups, new FA genes remain to be identified. In addition the complex FA network remains to be further unravelled. One of the FA genes, FANCI, has been identified via a combination of bioinformatic techniques exploiting FA protein properties and genetic linkage. The aim of this study was to develop a prioritization approach for proteins of the entire human proteome that potentially interact with the FA/BRCA pathway or are novel candidate FA genes. To this end, we combined the original bioinformatics approach based on the properties of the first thirteen FA proteins identified with publicly available tools for protein-protein interactions, literature mining (Nermal and a protein function prediction tool (FuncNet. Importantly, the three newest FA proteins FANCO/RAD51C, FANCP/SLX4, and XRCC2 displayed scores in the range of the already known FA proteins. Likewise, a prime candidate FA gene based on next generation sequencing and having a very low score was subsequently disproven by functional studies for the FA phenotype. Furthermore, the approach strongly enriches for GO terms such as DNA repair, response to DNA damage stimulus, and cell cycle-regulated genes. Additionally, overlaying the top 150 with a haploinsufficiency probability score, renders the approach more tailored for identifying breast cancer related genes. This approach may be useful for prioritization of putative novel FA or breast cancer genes from next generation sequencing efforts.

  14. Intoxicaciones agudas graves en un servicio de medicina intensiva durante doce años

    Directory of Open Access Journals (Sweden)

    César Palazón Sánchez

    2000-01-01

    Full Text Available Conocer 12 epidemiología de las u~tux~- aciones agudas graves en un servicio de medicina intensiva y evaluar el pronóstico de la PCR y mortalidad asociada a los distintos tóxicos.

  15. Efectividad de la magnetoterapia como tratamiento en pacientes con lumbalgia aguda

    Directory of Open Access Journals (Sweden)

    Raidel González Rodríguez

    2015-05-01

    Full Text Available Son numerosos los pacientes aquejados de algias vertebrales, tanto lumbares como dorsales y cervicales. Se realizó esta investigación con el objetivo de determinar la efectividad de la magnetoterapia como tratamiento en la lumbalgia aguda, en pacientes atendidos en el policlínico universitario “Raúl Sánchez” de la provincia de Pinar del Río, Cuba. Se realizó un estudio descriptivo, prospectivo, de corte transversal en pacientes con lumbalgia aguda, pertenecientes a dicha área de salud. La muestra quedó conformada por 68 pacientes de ambos sexos con lumbalgia aguda, diagnosticados clínicamente y mayores de 17 años de edad. En la investigación predominó el sexo femenino (67,6 % y el rango de edad estuvo entre 40 y 49 años. El esfuerzo físico fue el principal factor desencadenante (47,1 %. Con el tratamiento de la magnetoterapia aplicado a los pacientes se redujeron los estadios del dolor. La mayoría de los pacientes presentaron una respuesta clínica excelente y mejoraron los síntomas entre los siete y diez días (61,8 %. No se reportaron efectos adversos. La magnetoterapia resultó efectiva en el tratamiento de pacientes aquejados de lumbalgia aguda

  16. Incidencia de la enfermedad diarreica aguda en menores de cinco años

    Directory of Open Access Journals (Sweden)

    Mayelín Ávila Labrada

    2015-05-01

    Full Text Available La enfermedad diarreica aguda es motivo frecuente de consulta pediátrica, representando un problema grave de salud pública. Los agentes infecciosos son causa frecuente de diarrea aguda. Se realizó un estudio descriptivo, retrospectivo sobre la prevalencia de la enfermedad diarreica aguda en menores de cinco años, atendidos en la clínica “Simón Bolívar” en la ciudad de Mariara del municipio Diego Ibarra, Carabobo, Venezuela; en el periodo comprendido entre enero de 2008 y diciembre de 2012, lo cual ofreció información de cinco años completos. La prevalencia de la enfermedad diarreica aguda disminuyó significativamente en el intervalo 2009-2011, sin embargo, se caracterizó por tener la mayor prevalencia en los años extremos, 2012 y 2008, por ese orden. Los varones y los del grupo de uno a cuatro años fueron los que más incidieron en cada uno de los años estudiados

  17. Fisiopatología de la diarrea aguda

    Directory of Open Access Journals (Sweden)

    Raúl L. Riverón Corteguera

    1999-06-01

    Full Text Available Es un artículo de revisión de los aspectos importantes de la fisiopatología de la diarrea. Se hace una descripción de la fisiopatología intestinal que incluye la anatomía del intestino y de su superficie de absorción y la estructura funcional de la mucosa intestinal. La fisiopatología normal de los líquidos intestinales. Mecanismo de absorción del agua y los electrólitos. Absorción de sodio por difusión electrogénica, unido al ion cloro, intercambio con el ion hidrógeno y unido a sustancias orgánicas como glucosa, aminoácidos y algunos oligopéptidos; secreción intestinal de agua y electrólitos. Control intracelular de la secreción. Mediadores y moduladores extracelulares del transporte intestinal. Factores que aumentan la absorción y reducen la secreción. Factores que estimulan la secreción y reducen la absorción Mecanismo fisiopatológico de la diarrea. Clasificación de la diarrea infecciosa aguda: acuosa secretoria y osmótica; diarrea con sangre invasiva y no invasiva.This a review of some important aspects of the physiopathology of diarrhea. A description is made of the intestinal physiopathology, including the anatomy of the intestine and of its surface of absorption, as well as the functional structure of the intestinal mucosa: the normal physiopathology of the intestinal fluids; the mechanism of absorption of water and electrolites; the absorption of sodium by electrogenic difussion, joined to the chloride ion; the interchange with the hydrogen ion and attached to organic substances, such as glucose, aminoacids and some oligopeptides; the intestinal secretion of water and electrolites; the intracellular control of secretion, the extracellular mediators and modulators of intestinal transport; the factors that increase absorption and reduce secretion; the factors that stimulate secretion and absorption; and the physiopathological mechanism of diarrhea. The classification of acute infectious diarrhea in aqueous

  18. Linfonodo pulmonar na paracoccidioidomicose aguda infantil (relato de um caso

    Directory of Open Access Journals (Sweden)

    Evanil Pires de Campos

    1992-09-01

    Full Text Available Observou-se a evolução de um linfonodo pulmonar na paracoccidioidomicose (PCM aguda infantil. Doente, masculino, 6 anos, branco, natural de Curitiba (PR, procedente de Guaratinguetá (SP, que há 3 meses desenvolveu quadro gripal, febre diária, bimodal, prolongada, precedida de calafrio, acompanhada de sudorese inodora, cefaléia frontal e anorexia. Diagnosticado e tratado como pneumonia por cinco dias, sem melhora do quadro. Há 2 meses, apresentou dor óssea nos braços e articulações do pé, com edema inflamatório e emagrecimento de 6 kg em 3 meses. Exame físico revelou: peso 20 kg; estatura 120 cm; P. A. 90/60 mmHg; facies atípica, hipoativo, palidez cutâneo-mucosa (+ +, hipotrofia muscular, adenopatiageneralizada, sopro sistólico suave em foco aórtico acessório e hepatesplenomegalia. Imunodifusão com exoantígeno glicoprotéico 43 kdpositiva (1/32. A biópsia de gânglio revelou Paracoccidioides brasiliensis. A radiologia demonstrou na primeira consulta, discreto infiltrado intersticial bilateral com linfoadenomegaliapara-hilar que desaparecu em 30 dias. Observou- se, ainda, massa tumoral mediastínica superior, hiperplasia do sistema fagocítico mononuclear e lesões osteolíticas nos 60 dias iniciais da evolução.The primary complex like Ghon was observed in a child's clinical roentgenographic study. C.S., white, male, 6 years old, was born in Curitiba (PR, Brazil and living in Guaratingueta (SP, Brazil, developed "common cold", bimodal diary fever, chills, shake and sweats. Dyspnea, cough with general fymphadenopathy. Foot and right shoulder artralgies. Six months ago visited a cave, equitation practice, dog and cat contacts and notransfusion, frontal sweats, fever (38.4°C. T.A. was 8/6, tachicardia in generalizated fymphadenopathy. Cardiopulmonary system was normal, mesogastric tumoral mass, hepatesplenomegaly and no ascitis. Bone marrow with eosinophilia; nodule demonstred presence of P. brasiliensis; hypoalbuminemia

  19. Opuntia ficus indica (nopal) attenuates hepatic steatosis and oxidative stress in obese Zucker (fa/fa) rats.

    Science.gov (United States)

    Morán-Ramos, Sofía; Avila-Nava, Azalia; Tovar, Armando R; Pedraza-Chaverri, José; López-Romero, Patricia; Torres, Nimbe

    2012-11-01

    Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors such as obesity, insulin resistance, and oxidative stress. Nopal, a cactus plant widely consumed in the Mexican diet, is considered a functional food because of its antioxidant activity and ability to improve biomarkers of metabolic syndrome. The aim of this study was to assess the effect of nopal consumption on the development of hepatic steatosis and hepatic oxidative stress and on the regulation of genes involved in hepatic lipid metabolism. Obese Zucker (fa/fa) rats were fed a control diet or a diet containing 4% nopal for 7 wk. Rats fed the nopal-containing diet had ∼50% lower hepatic TG than the control group as well as a reduction in hepatomegaly and biomarkers of hepatocyte injury such as alanine and aspartate aminotransferases. Attenuation of hepatic steatosis by nopal consumption was accompanied by a higher serum concentration of adiponectin and a greater abundance of mRNA for genes involved in lipid oxidation and lipid export and production of carnitine palmitoyltransferase-1 and microsomal TG transfer proteins in liver. Hepatic reactive oxygen species and lipid peroxidation biomarkers were significantly lower in rats fed nopal compared with the control rats. Furthermore, rats fed the nopal diet had a lower postprandial serum insulin concentration and a greater liver phosphorylated protein kinase B (pAKT):AKT ratio in the postprandial state. This study suggests that nopal consumption attenuates hepatic steatosis by increasing fatty acid oxidation and VLDL synthesis, decreasing oxidative stress, and improving liver insulin signaling in obese Zucker (fa/fa) rats.

  20. CFD Analysis of a Maneuvering F/A-18E Super Hornet

    Science.gov (United States)

    2016-10-12

    tools for aircraft, ships, and radio - frequency antenna design and analysis. The resulting program is called the Computational Research and Engineering...accurately predicting the forces and moments on the F/A-18E Super Hornet while performing several complicated maneuvers. Past F/A-18E computational studies... predicting the forces and moments on the F/A-18E Super Hornet while performing several complicated maneuvers. Past F/A-18E computational studies have

  1. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair

    Science.gov (United States)

    Leung, Justin Wai Chung; Wang, Yucai; Fong, Ka Wing; Huen, Michael Shing Yan; Li, Lei; Chen, Junjie

    2012-01-01

    The Fanconi anemia (FA) pathway participates in interstrand cross-link (ICL) repair and the maintenance of genomic stability. The FA core complex consists of eight FA proteins and two Fanconi anemia-associated proteins (FAAP24 and FAAP100). The FA core complex has ubiquitin ligase activity responsible for monoubiquitination of the FANCI-FANCD2 (ID) complex, which in turn initiates a cascade of biochemical events that allow processing and removal of cross-linked DNA and thereby promotes cell survival following DNA damage. Here, we report the identification of a unique component of the FA core complex, namely, FAAP20, which contains a RAD18-like ubiquitin-binding zinc-finger domain. Our data suggest that FAAP20 promotes the functional integrity of the FA core complex via its direct interaction with the FA gene product, FANCA. Indeed, somatic knockout cells devoid of FAAP20 displayed the hallmarks of FA cells, including hypersensitivity to DNA cross-linking agents, chromosome aberrations, and reduced FANCD2 monoubiquitination. Taking these data together, our study indicates that FAAP20 is an important player involved in the FA pathway. PMID:22396592

  2. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair.

    Science.gov (United States)

    Leung, Justin Wai Chung; Wang, Yucai; Fong, Ka Wing; Huen, Michael Shing Yan; Li, Lei; Chen, Junjie

    2012-03-20

    The Fanconi anemia (FA) pathway participates in interstrand cross-link (ICL) repair and the maintenance of genomic stability. The FA core complex consists of eight FA proteins and two Fanconi anemia-associated proteins (FAAP24 and FAAP100). The FA core complex has ubiquitin ligase activity responsible for monoubiquitination of the FANCI-FANCD2 (ID) complex, which in turn initiates a cascade of biochemical events that allow processing and removal of cross-linked DNA and thereby promotes cell survival following DNA damage. Here, we report the identification of a unique component of the FA core complex, namely, FAAP20, which contains a RAD18-like ubiquitin-binding zinc-finger domain. Our data suggest that FAAP20 promotes the functional integrity of the FA core complex via its direct interaction with the FA gene product, FANCA. Indeed, somatic knockout cells devoid of FAAP20 displayed the hallmarks of FA cells, including hypersensitivity to DNA cross-linking agents, chromosome aberrations, and reduced FANCD2 monoubiquitination. Taking these data together, our study indicates that FAAP20 is an important player involved in the FA pathway.

  3. A protein prioritization approach tailored for the FA/BRCA pathway

    NARCIS (Netherlands)

    Haitjema, A.; Brandt, B.W.; Ameziane, N.; May, P.; Heringa, J.; de Winter, J.P.; Joenje, H.; Dorsman, J.C.

    2013-01-01

    Fanconi anemia (FA) is a heterogeneous recessive disorder associated with a markedly elevated risk to develop cancer. To date sixteen FA genes have been identified, three of which predispose heterozygous mutation carriers to breast cancer. The FA proteins work together in a genome maintenance

  4. A Protein Prioritization Approach Tailored for the FA/BRCA Pathway

    NARCIS (Netherlands)

    Haitjema, A.; Brandt, B.W.; Ameziane, N.; May, P.; Heringa, J.; de Winter, J.P.; Joenje, H.; Dorsman, J.C.

    2013-01-01

    Fanconi anemia (FA) is a heterogeneous recessive disorder associated with a markedly elevated risk to develop cancer. To date sixteen FA genes have been identified, three of which predispose heterozygous mutation carriers to breast cancer. The FA proteins work together in a genome maintenance

  5. Deterministic Assessment of Future Costs for Dismantling (FA)

    Energy Technology Data Exchange (ETDEWEB)

    Vasko, Marek [DECOM, Trnava (Slovakia)

    2012-11-01

    The main objective of the report is to provide an re-evaluation of cost calculations by OMEGA code for the Intermediate Storage for Spent Fuel in Studsvik (FA facility) using up-to-date Swedish labour cost unit factors and available up-to-date Swedish (or international) cost unit factors for consumables, materials and substances. Furthermore, evolution of other OMEGA database parameters concerning cost calculations e.g. manpower unit factors and workgroups parameters are taken into account. This report follows up former project which introduced tentative calculations of main decommissioning parameters such as costs, manpower and exposure of personnel for activities of older nuclear facility decommissioning in Sweden represented by FA Facility in Studsvik by means of calculation code OMEGA. The project demonstrated an implementation of advanced costing methodology based on PSL structure format to achieve transparent, traceable and comparable estimates even for older nuclear facilities like FA Facility in Studsvik. This former project used Slovak origin labour costs unit factors and other cost unit factors. After successful completion of this project, there was an intent of SSM to reevaluate calculations using an up-to-date Swedish labour cost data and also available Swedish consumables and materials cost data if available. Within this report re-calculations of main decommissioning parameters using available Swedish data are presented in structure according to Proposed Standardized List of Items for Costing Purposes. Calculations are made for decommissioning scenario with post-dismantling decontamination and steel radwaste melting technologies available at the site. All parameters are documented and summed up in both table and graphic forms in text and Annexes. Further, comparison of calculated results with previous calculations together with discussion is provided.

  6. Deterministic Assessment of Future Costs for Dismantling (FA)

    International Nuclear Information System (INIS)

    Vasko, Marek

    2012-03-01

    The main objective of the report is to provide an re-evaluation of cost calculations by OMEGA code for the Intermediate Storage for Spent Fuel in Studsvik (FA facility) using up-to-date Swedish labour cost unit factors and available up-to-date Swedish (or international) cost unit factors for consumables, materials and substances. Furthermore, evolution of other OMEGA database parameters concerning cost calculations e.g. manpower unit factors and workgroups parameters are taken into account. This report follows up former project which introduced tentative calculations of main decommissioning parameters such as costs, manpower and exposure of personnel for activities of older nuclear facility decommissioning in Sweden represented by FA Facility in Studsvik by means of calculation code OMEGA. The project demonstrated an implementation of advanced costing methodology based on PSL structure format to achieve transparent, traceable and comparable estimates even for older nuclear facilities like FA Facility in Studsvik. This former project used Slovak origin labour costs unit factors and other cost unit factors. After successful completion of this project, there was an intent of SSM to reevaluate calculations using an up-to-date Swedish labour cost data and also available Swedish consumables and materials cost data if available. Within this report re-calculations of main decommissioning parameters using available Swedish data are presented in structure according to Proposed Standardized List of Items for Costing Purposes. Calculations are made for decommissioning scenario with post-dismantling decontamination and steel radwaste melting technologies available at the site. All parameters are documented and summed up in both table and graphic forms in text and Annexes. Further, comparison of calculated results with previous calculations together with discussion is provided

  7. Formal characterizations of FA-based string processors

    CSIR Research Space (South Africa)

    Ngassam, EK

    2010-08-01

    Full Text Available stream_source_info Ngassam_2010.pdf.txt stream_content_type text/plain stream_size 7434 Content-Encoding UTF-8 stream_name Ngassam_2010.pdf.txt Content-Type text/plain; charset=UTF-8 Formal Characterizations of FA...-based String Processors Ernest Ketcha Ngassam1,2,?, Bruce W. Watson3, and Derrick G. Kourie3 1SAP Meraka UTD, Pretoria, South Africa 2School of Computing University of South Africa Pretoria 0001 ernest.ngassam@sap.com 3Department of Computer Science...

  8. VVER-440 fuel cycles possibilities using modified FA design

    International Nuclear Information System (INIS)

    Mikolas, P.; Svarny, J.; Razym, V.; Dostal, M.; Jenik, J.; Krupar, P.

    2009-01-01

    A nearly equilibrium five-year cycle has been achieved at Dukovany NPP over the last years. This means that working fuel assemblies (WFA) with an average enrichment of 4.25 w% (control assemblies (CA) with an average enrichment of 3.82 w%) are normally loaded and reloaded for five years. Operation at uprated thermal power (105% of the original one, increase from 1375 MW t to 1444 MW t ) is being prepared by use of WFA with an average enrichment of 4.38 w% (CA with an average enrichment of 4.25 w%). With the aim of fuel cycle economy improvement, the fuel residence time in the core has to be prolonged up to six years with one cycle duration time up to 18 months and preserving loadings with very low leakage. In order to achieve this goal, at least neutron-physical characteristics of FA must be improved and such changes should be evaluated from other viewpoints. Some particular changes have already been analyzed earlier. Designs of new fuel assemblies with higher (and in the central part of a FA the highest possible, i.e. 4.95 w%) enrichment with preserving low pin power non-uniformity are described in the presented paper. An FA with an average enrichment of 4.66 w% (lower than originally evaluated) containing six fuel pins with 3.35 w% Gd 2 O 3 content was selected in the end. Fuel pins have bigger pellet diameter, bigger pin pitch and thinner FA shroud. A newly designed FA was evaluated from the viewpoint of physics (pin power non-uniformity, criticality of fuel at transport and storage and determination of basic quantities for spent fuel storage purposes by ORIGEN code), thermo-hydraulics (comparison of subchannel output temperatures and the departure from nucleate boiling ratio - DNBR) and mechanical properties. The purpose of this study was to simulate an FA subject to the loads during its six- year lifetime whereas normal working conditions were taken into account. There are presented two models with different shroud thickness undergoing these analyses. Both

  9. FaPOD27 functions in the metabolism of polyphenols in strawberry fruit (Fragaria sp.

    Directory of Open Access Journals (Sweden)

    Su-Ying eYeh

    2014-10-01

    Full Text Available The strawberry (Fragaria × ananassa is one of the most preferred fresh fruit worldwide, accumulates numerous flavonoids but has limited shelf life due to excessive tissue softening caused by cell wall degradation. Since lignin is one of the polymers that strengthen plant cell walls and might contribute to some extent to fruit firmness monolignol biosynthesis was studied in strawberry fruit. Cinnamoyl-CoA reductase (CCR, cinnamyl alcohol dehydrogenase (CAD, and a peroxidase (POD27 gene were strongly expressed in red, ripe fruit whereas a second POD gene was primarily expressed in green, immature fruit. Moreover, FaPOD27 transcripts were strongly and constitutively induced in fruits exposed to Agrobacterium infection. Gene expression levels and enzymatic activities of FaCCR and FaCAD were efficiently suppressed through RNAi in FaCCR- and FaCAD-silenced strawberries. Besides, significantly elevated FaPOD transcript levels were detected after agroinfiltration of pBI-FaPOD constructs in fruits. At the same time, levels of G-monomers were considerably reduced in FaCCR-silenced fruits whereas the proportion of both G- and S-monomers decisively decreased in FaCAD-silenced and pBI-FaPOD fruits. Development, firmness, and lignin level of the treated fruits were similar to pBI-intron control fruits, presumably attributed to increased expression levels of FaPOD27 upon agroinfiltration. Additionally, enhanced firmness, accompanied with elevated lignin levels, was revealed in chalcone synthase-deficient fruits (CHS-, independent of down- or up-regulation of individual and combined FaCCR, FaCAD, and FaPOD genes by agroinfiltration, when compared to CHS-/pBI-intron control fruits. These approaches provide further insight into the genetic control of flavonoid and lignin synthesis in strawberries. The results suggest that FaPOD27 is a key gene for lignin biosynthesis in strawberry fruit and thus to improving the firmness of strawberries.

  10. Whole exome sequencing reveals concomitant mutations of multiple FA genes in individual Fanconi anemia patients.

    Science.gov (United States)

    Chang, Lixian; Yuan, Weiping; Zeng, Huimin; Zhou, Quanquan; Wei, Wei; Zhou, Jianfeng; Li, Miaomiao; Wang, Xiaomin; Xu, Mingjiang; Yang, Fengchun; Yang, Yungui; Cheng, Tao; Zhu, Xiaofan

    2014-05-15

    Fanconi anemia (FA) is a rare inherited genetic syndrome with highly variable clinical manifestations. Fifteen genetic subtypes of FA have been identified. Traditional complementation tests for grouping studies have been used generally in FA patients and in stepwise methods to identify the FA type, which can result in incomplete genetic information from FA patients. We diagnosed five pediatric patients with FA based on clinical manifestations, and we performed exome sequencing of peripheral blood specimens from these patients and their family members. The related sequencing data were then analyzed by bioinformatics, and the FANC gene mutations identified by exome sequencing were confirmed by PCR re-sequencing. Homozygous and compound heterozygous mutations of FANC genes were identified in all of the patients. The FA subtypes of the patients included FANCA, FANCM and FANCD2. Interestingly, four FA patients harbored multiple mutations in at least two FA genes, and some of these mutations have not been previously reported. These patients' clinical manifestations were vastly different from each other, as were their treatment responses to androstanazol and prednisone. This finding suggests that heterozygous mutation(s) in FA genes could also have diverse biological and/or pathophysiological effects on FA patients or FA gene carriers. Interestingly, we were not able to identify de novo mutations in the genes implicated in DNA repair pathways when the sequencing data of patients were compared with those of their parents. Our results indicate that Chinese FA patients and carriers might have higher and more complex mutation rates in FANC genes than have been conventionally recognized. Testing of the fifteen FANC genes in FA patients and their family members should be a regular clinical practice to determine the optimal care for the individual patient, to counsel the family and to obtain a better understanding of FA pathophysiology.

  11. Detección molecular de las translocaciones más comunes en Leucemia aguda mediante RT-PCR

    Directory of Open Access Journals (Sweden)

    L. García

    2001-07-01

    Full Text Available Evaluar la incidencia de las translocaciones t(4;11, t(1;19, t(9;22 y t(12;21 en leucemia linfoide aguda (LLA y t(15;17, t(8;21 e Inv.(16 en leucemia mieloide aguda (LMA. Correlacionar los resultados obtenidos con el diagnóstico morfológico y citogenético.

  12. Solution Validation for a Double Façade Prototype

    Directory of Open Access Journals (Sweden)

    Pau Fonseca i Casas

    2017-12-01

    Full Text Available A Solution Validation involves comparing the data obtained from the system that are implemented following the model recommendations, as well as the model results. This paper presents a Solution Validation that has been performed with the aim of certifying that a set of computer-optimized designs, for a double façade, are consistent with reality. To validate the results obtained through simulation models, based on dynamic thermal calculation and using Computational Fluid Dynamic techniques, a comparison with the data obtained by monitoring a real implemented prototype has been carried out. The new validated model can be used to describe the system thermal behavior in different climatic zones without having to build a new prototype. The good performance of the proposed double façade solution is confirmed since the validation assures there is a considerable energy saving, preserving and even improving interior comfort. This work shows all the processes in the Solution Validation depicting some of the problems we faced and represents an example of this kind of validation that often is not considered in a simulation project.

  13. O perfil da antiestreptolisina O no diagnóstico da febre reumática aguda Antistreptolysin O titer profile in acute rheumatic fever diagnosis

    Directory of Open Access Journals (Sweden)

    Claudia Saad Magalhães Machado

    2001-04-01

    Full Text Available OBJETIVO: estabelecer o perfil dos títulos de ASO, mediante o diagnóstico diferencial da FRA com outras afecções que também cursam com níveis elevados de ASO. MÉTODOS: foram estudados 78 casos de FRA na apresentação e seguimento, 22 de coréia isolada, 45 de infecções orofaringeanas recorrentes (IOR e 23 de artrites idiopáticas juvenis (AIJ, com início ou reativação recente. A determinação seqüencial de ASO (UI/ml foi realizada por ensaio nefelométrico automatizado (Behring®-Germany nos períodos de 0-7 dias, 1-2 semanas, 2-4 semanas, 1-2 meses, 2-4 meses, 4-6 meses, 6-12 meses, 1-2 anos, 2-3 anos, 3-4 anos e 4-5 anos após o diagnóstico. RESULTADOS: os títulos de ASO na fase aguda da FRA apresentaram elevação significante até o intervalo de 2- 4 meses (p 960 UI/ml. CONCLUSÃO: esta reavaliação do perfil da ASO indicou uma resposta exuberante na fase aguda da febre reumática indicou ainda que os seus níveis séricos podem diferenciá-la de outras afecções que também cursam com níveis elevados de ASO, como as infecções orofaringeanas recorrentes ou as artrites idiopáticas juvenis em atividade.OBJECTIVE: to determine ASO titer profile by establishing ARF differential diagnoses of other diseases with high levels of ASO antibodies. METHODS: we investigated 78 patients with ARF at onset and follow-up, 22 with isolated chorea at onset, 45 with recurrent oropharyngeal tonsillitis, and 23 with recent flare of juvenile idiopathic arthritis. We tested ASO with automated particle-enhanced immunonephelometric assay (Behring®-Germany. The ASO (IU/ml titers were assessed at the following time intervals: 0-7 days, 1-2 weeks, 2-4 weeks, 1-2 months, 2-4 months, 4-6 months, 6-12 months, 1-2 years, 2-3 years, 3-4 years, and 4-5 years after onset of ARF. RESULTS: ASO titers in patients diagnosed with ARF had a significant increase up to the 2-4-month time interval (P < 0.0001. Baseline levels were observed afterwards in patients

  14. Esofagitis necrosante aguda: análisis retrospectivo Acute esophageal necrosis: a retrospective case series

    Directory of Open Access Journals (Sweden)

    R. Ramos

    2008-09-01

    Full Text Available Introducción: la esofagitis necrosante aguda es una entidad rara. Se reconoce por el aspecto negro difuso del esófago a la endoscopia. Su incidencia e patogénesis se desconoce. Pacientes y métodos: se analizaron retrospectivamente 11 pacientes con esofagitis necrosante aguda desde el punto de vista de los datos clínicos, de laboratorio y endoscopicos en 2 años. Resultados: se analizaron las endoscopias realizadas a 3.976 pacientes, observándose esofagitis necrosante aguda en 11 pacientes. El estado nutricional era malo en 6 pacientes. La resolución completa de la esofagitis se observó en cuatro pacientes. Durante el seguimiento se observó una estenosis en un paciente y un nuevo episodio de esofagitis necrosante aguda en otro paciente. Siete pacientes fallecieron, pero esta elevada mortalidad parece deberse a las enfermedades de base y no es atribuible a las lesiones de la esofagitis necrosante. Conclusiones: la incidencia de esofagitis necrosante aguda en nuestra serie fue 0,28%. La esofagitis necrosante aguda tiene una elevada mortalidad.Background: acute esophageal necrosis has been considered a rare event. It is defined as the presence of diffuse dark pigmentation of the esophagus on upper endoscopy. Its incidence has not yet been established. The pathogenesis remains unknown. Patients and methods: a retrospective analysis of clinical, laboratory, endoscopic, and histological data, and of the clinical course of 11 patients with acute necrotizing esophagitis was carried out over a 2-year period. Results: among 3,976 patients who underwent upper endoscopy, 11 (0.28% with acute esophageal necrosis were identified. Nutritional status was poor for 6 patients. Complete resolution of acute esophageal necrosis without further recurrence was observed in 4. One stricture appeared during follow-up and other patient developed new-onset acute esophageal necrosis. Seven patients died, but no death was directly related to acute esophageal necrosis

  15. Estado oxidante e antioxidante de crianças com bronquiolite aguda

    Directory of Open Access Journals (Sweden)

    Rusen Dundaroz

    2013-08-01

    Full Text Available OBJETIVO: O estresse oxidativo demonstrou contribuir para a patogênese de doenças pulmonares inflamatórias agudas e crônicas. Nosso objetivo foi avaliar o estado oxidante/antioxidante de crianças com bronquiolite aguda por meio de mensuração da capacidade antioxidante total do plasma, estado oxidante total e índice de estresse oxidativo. MÉTODOS: As crianças com bronquiolite aguda encaminhadas para o Departamento de Emergência Pediátrica do hospital universitário entre janeiro e abril 2012 foram comparadas a controles saudáveis de mesma idade. Os pacientes com bronquiolite aguda tiveram essa doença classificada como leve e moderada. O estado oxidante e antioxidante foi avaliado pela mensuração da capacidade antioxidante total do plasma, estado oxidante total e índice de estresse oxidativo. RESULTADOS: Foram incluídas 31 crianças com bronquiolite aguda com idade de três meses a dois anos e 37 crianças saudáveis. O estado oxidante total (EOT foi maior em pacientes com bronquiolite aguda do que no grupo de controle (5,16±1,99 µmol H2O2 em comparação a 3,78±1,78 µmol H2O2 [p = 0,004]. A capacidade antioxidante total (CAT foi significativamente menor em crianças com bronquiolite que no grupo de controle (2,51±0,37 µmol Trolox equivalente/L em comparação a 2,75±0,39 µmol Trolox Eqv/L (p = 0,013. Os pacientes com bronquiolite moderada apresentaram níveis de EOT mais elevados que os com bronquiolite leve e os do grupo de controle (p = 0,03, p < 0,001. Os pacientes com bronquiolite moderada apresentaram níveis de IEO mais elevados que os do grupo de controle (p = 0,015. O nível de saturação de oxigênio de pacientes com bronquiolite foi inversamente correlacionado ao nível de EOT (r = -0,476, p < 0,05. CONCLUSÃO: O equilíbrio entre os sistemas oxidante e antioxidante é interrompido em crianças com bronquiolite moderada, indicando que o fator de estresse poderá ter um papel na patogênese da doença.

  16. Manejo da hipertensão arterial na isquemia cerebral aguda Management of arterial hypertension in patients with acute ischemic stroke

    Directory of Open Access Journals (Sweden)

    WALTER JOSÉ FAGUNDES-PEREYRA

    1999-12-01

    Full Text Available OBJETIVO: Avaliar o nível de conhecimento dos médicos, através de sua conduta, em paciente com quadro de hipertensão arterial na fase aguda da isquemia cerebral. Também comentamos as principais condutas nesta fase, com ênfase na tensão arterial (TA. MÉTODO: Foram entrevistados 120 médicos da clínica médica e da cirurgia geral, em dez dos maiores Hospitais de Belo Horizonte, em 1997. Todos responderam a um questionário contendo um caso clínico de paciente hipertenso leve, admitido com quadro de isquemia cerebral e tensão arterial de 186x110 mmHg. Os profissionais deveriam optar por reduzir, aumentar ou manter a TA. RESULTADOS: Dos entrevistados, 38 (31,7% responderam que reduziriam os níveis tensionais, 82 (68,3% optaram pela manutenção e nenhum aumentaria (pPURPOSE: We aimed with study to assess the current clinical practice about the management of high blood pressure in patients in the acute phase of ischemic stroke. We also comment some topics of ischemic stroke treatment. METHODS: A case report of a patient admitted 8 hours after onset of ischemic stroke and with blood pressure of 186x110 mmHg was presented to 120 surgeons and clinician. They were asked to decide the best therapeutic option: to increase, decrease or maintenance blood pressure. RESULTS: Thirty-eight physicians (31,7% considered decreasing blood pressure the best therapeutics, 82 (68,3% considered maintenance and none decided to increase it (p < 0.05. There was no difference between the two specialties conduct. The physicians, with more than 10 years of graduation, had a tendency to decrease the blood pressure (p <0.05. CONCLUSION: The maintenance of blood pressure may present a sufficient blood support to compensate brain flow. A high percentage of the physicians (31,7% do not know about the current concepts of therapeutics considering hypertension in acute ischemic stroke. The development on special units to treat these patients ("stroke units" may eventually

  17. Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats.

    Science.gov (United States)

    Daubioul, Catherine; Rousseau, Nicolas; Demeure, Roger; Gallez, Bernard; Taper, Henryk; Declerck, Barbara; Delzenne, Nathalie

    2002-05-01

    This study was designed to compare the effects of dietary supplementation with nondigestible carbohydrates, differing in fermentability by colonic bacteria, on hepatic steatosis in growing obese Zucker rats. Male Zucker fa/fa rats were divided into three groups: a control group that received the basal diet, a fructan group that received 10 g highly fermented Synergy 1/100 g diet and a cellulose group that received 10 g poorly fermented Vivapur Microcrystalline cellulose/100 g diet. Rats consuming fructan had a lower energy intake, a lower body weight and less triacylglycerol accumulation in the liver as assessed in vivo by nuclear magnetic resonance (NMR) spectroscopy, and ex vivo by biochemical and histochemical analysis compared with the control and/or cellulose groups. The high fermentation of fructans compared with cellulose was reflected by greater cecal contents and by a twofold greater propionate concentration in the portal vein of rats fed fructan compared with those fed cellulose. By measuring the capacity of hepatocytes isolated from liver of Zucker rats to synthesize triglycerides or total lipids from different precursors, we showed that propionate, at the concentrations measured in the portal vein of rats treated with fructan, selectively decreased the incorporation of acetate into total lipids, a phenomenon that could contribute, along with the lower energy intake, to less triglyceride accumulation in the liver of obese Zucker rats fed dietary fructans.

  18. Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in Zucker fa/fa rats.

    Science.gov (United States)

    Jiao, Jian; Bae, Eun Ju; Bandyopadhyay, Gautam; Oliver, Jason; Marathe, Chaitra; Chen, Michael; Hsu, Jer-Yuan; Chen, Yu; Tian, Hui; Olefsky, Jerrold M; Saberi, Maziyar

    2013-04-01

    Gastrointestinal bypass surgeries that result in rerouting and subsequent exclusion of nutrients from the duodenum appear to rapidly alleviate hyperglycemia and hyperinsulinemia independent of weight loss. While the mechanism(s) responsible for normalization of glucose homeostasis remains to be fully elucidated, this rapid normalization coupled with the well-known effects of vagal inputs into glucose homeostasis suggests a neurohormonally mediated mechanism. Our results show that duodenal bypass surgery on obese, insulin-resistant Zucker fa/fa rats restored insulin sensitivity in both liver and peripheral tissues independent of body weight. Restoration of normoglycemia was attributable to an enhancement in key insulin-signaling molecules, including insulin receptor substrate-2, and substrate metabolism through a multifaceted mechanism involving activation of AMP-activated protein kinase and downregulation of key regulatory genes involved in both lipid and glucose metabolism. Importantly, while central nervous system-derived vagal nerves were not essential for restoration of insulin sensitivity, rapid normalization in hepatic gluconeogenic capacity and basal hepatic glucose production required intact vagal innervation. Lastly, duodenal bypass surgery selectively altered the tissue concentration of intestinally derived glucoregulatory hormone peptides in a segment-specific manner. The present data highlight and support the significance of vagal inputs and intestinal hormone peptides toward normalization of glucose and lipid homeostasis after duodenal bypass surgery.

  19. Heterose em suínos na fase de aleitamento

    Directory of Open Access Journals (Sweden)

    José Bento Sterman Ferraz

    1991-12-01

    Full Text Available Visando avaliar o ganho de produtividade, advindo da heterose, no peso de suínos em fase de aleitamento, analisaram-se os pesos ao nascimento(PO, 21 dias de idade (P21 e desmama (PD de 746leitões, sendo 201 da raça Landrace, 136 Wessex-Saddleback e 409 mestiços, pelo método dos quadrados mínimos, considerando-se, ainda, os efeitos fixos de época e ano de nascimento, ordem do parto, sexo do leitão e tamanho da leitegada, além de raças paterna e materna e suas interações. Os efeitos não genéticos tiveram influência significativa em quase todas as características. Os mestiços mostraram, em geral, pesos superiores aos puros, com estimativas de heterose de 2,6% para PO, 9,7% para P21 e 13,9% para PD, indicando a importância da herança não aditiva à medida que os leitões ficam menos dependentes de suas mães. Os efeitos de interação entre as raças paterna e materna foram cada vez maiores com o avançar da idade. Os resultados indicam haver ganho de produtividade coma utilização deste tipo de cruzamento.

  20. Cerebelite aguda causada por vírus Epstein-Barr: relato de caso

    Directory of Open Access Journals (Sweden)

    Teive Hélio A.G.

    2001-01-01

    Full Text Available A cerebelite aguda pode ocorrer em associação a infecção pelo vírus da varicela-zoster, enterovirus, caxumba, micoplasma e outros agentes infecciosos. A cerebelite aguda é uma complicação rara da infecção pelo vírus Epstein-Barr (EBV. Relatamos o caso de uma mulher de 21 anos com história de 12 dias de evolução com náuseas, vômitos, ataxia de marcha e membros, tremor cefálico e de membros, opsoclono, mioclonias e rash cutâneo. Sorologia para EBV foi positiva. A infecção pelo EBV, com complicações neurológicas, pode não se apresentar com os sinais e sintomas clássicos da mononucleose infeciosa.

  1. Nutrição na pancreatite aguda : monografia : Nutrition in acute pancreatitis

    OpenAIRE

    Oliveira, Joana da Silva

    2009-01-01

    Resumo da tese:A pancreatite aguda (PA) é uma doença inflamatória aguda do pâncreas de etiologia multifactorial e pode ter atingimento local (PA ligeira a moderada) ou sistémico (PA grave). A magnitude da lesão pancreática, a presença e extensão da necrose e de infecção determinam o grau de gravidade. Prever a gravidade é fundamental para direccionar antecipadamente a terapêutica médica e nutricional. Na sua maioria, os episódios de PA são ligeiros a moderados, de resolução espontânea, enquan...

  2. Visualization of cranial nerves by MR cisternography using 3D FASE. Comparison with 2D FSE

    Energy Technology Data Exchange (ETDEWEB)

    Asakura, Hirofumi; Nakano, Satoru; Togami, Taro [Kagawa Medical School, Miki (Japan)] (and others)

    2001-03-01

    MR cisternography using 3D FASE was compared with that of 2D FSE in regard to visualization of normal cranial nerves. In a phantom study, contrast-to-noise ratio (C/N) of fine structures was better in 3D FASE images than in 2D FSE. In clinical cases, visualization of trigeminal nerve, abducent nerve, and facial/vestibulo-cochlear nerve were evaluated. Each cranial nerve was visualized better in 3D FASE images than in 2D FSE, with a significant difference (p<0.05). (author)

  3. Visualization of cranial nerves by MR cisternography using 3D FASE. Comparison with 2D FSE

    International Nuclear Information System (INIS)

    Asakura, Hirofumi; Nakano, Satoru; Togami, Taro

    2001-01-01

    MR cisternography using 3D FASE was compared with that of 2D FSE in regard to visualization of normal cranial nerves. In a phantom study, contrast-to-noise ratio (C/N) of fine structures was better in 3D FASE images than in 2D FSE. In clinical cases, visualization of trigeminal nerve, abducent nerve, and facial/vestibulo-cochlear nerve were evaluated. Each cranial nerve was visualized better in 3D FASE images than in 2D FSE, with a significant difference (p<0.05). (author)

  4. Dor aguda no joelho do paciente idoso Acute knee pain in elderly patients

    Directory of Open Access Journals (Sweden)

    Gilberto Luís Camanho

    2008-09-01

    Full Text Available A dor aguda no joelho de pacientes idosos é freqüente, sendo caracterizada por seu aparecimento súbito, sem causa aparente, com exame radiográfico dentro dos padrões da normalidade, na maioria dos casos. A etiologia da dor aguda no joelho é decorrente de insuficiência das estruturas, e seu quadro clínico difere completamente daquele determinado pela osteoartrose, sendo sempre unilateral e ocorre na grande maioria em pacientes do sexo feminino, após a quinta década de vida, e na região medial do joelho (local de maior carga. Com o propósito de analisar as possíveis etiologias para a dor aguda do joelho de pacientes acima de 60 anos de idade, suas características e tratamento, os autores discutem as etiologias relacionadas à dor aguda: lesão meniscal, fratura por fadiga e osteonecrose idiopática.Acute knee pain in elderly patients is not uncommon, and is characterized by a sudden onset, no apparent cause, and by normal radiographic findings in most cases. The etiology of acute knee pain is the result of insufficient structures, and clinical symptoms are totally different from the symptoms seen in osteoarthrosis. This acute pain in the knee is always unilateral and in the medial region of the knee joint (site with the heaviest load, predominantly in females after the fifth decade of live. In order to consider the possible etiologies for acute knee joint pain in patients older than 60 years, its characteristics and treatment, the authors discuss etiologies related to acute pain: lesion of the meniscus, stress fracture, and idiopathic osteonecrosis.

  5. Perfiles clínicos y hemodinámicos en pacientes con falla cardiaca aguda

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Calderón

    2017-09-01

    Conclusiones: la falla cardíaca aguda descompensada es el perfil de presentación clínica más común en nuestra población con dos tercios del total de casos. El perfil hemodinámico más frecuente fue el “caliente y húmedo” (Stevenson B, resultados que concuerdan con lo observado en estudios locales y registros internacionales.

  6. Relación entre las infecciones respiratorias agudas altas y el asma bronquial

    Directory of Open Access Journals (Sweden)

    Verónica Soler Fonseca

    Full Text Available Introducción: la infección respiratoria es la enfermedad más frecuente en los seres humanos, pues es responsable de la mitad de todas las enfermedades agudas. En Cuba al igual que en el resto del mundo, el asma bronquial constituye un importante problema de salud con incidencia relevante en los niños. Se señala que las infecciones virales están involucradas en la patogénesis del asma, sobre todo en el paciente pediátrico. Objetivo: identificar la influencia de las Infecciones Respiratorias Agudas Altas en la aparición y exacerbación de las crisis de asma bronquial. Métodos: se realizó un estudio descriptivo, transversal y prospectivo de los pacientes ingresados con asma bronquial en el servicio de enfermedades respiratorias del Hospital Pediátrico Docente de San Miguel del Padrón, durante todo el año 2008. Resultados: el tiempo de evolución de la IRAA más frecuente que desencadenó la crisis de asma bronquial fue de más de 7 días, con un 54,8 %. Un total de 188 pacientes presentaron rinofaringitis aguda catarral relacionada con la aparición de la crisis de asma bronquial, lo que representó el 82,4 % del total de la muestra. Conclusiones: predominó el grupo de 1 a 4 años con manifestaciones respiratorias altas de posible etiología viral sin diferencias apreciables en relación con el sexo. La mayoría de los pacientes que participaron en el estudio presentaron IRAA de etiología viral (Rinofaringitis, que precedieron la aparición y exacerbación de las crisis agudas de asma bronquial.

  7. Sertralina e pancreatite aguda: relato de caso Sertraline and acute pancreatitis: a case-report

    Directory of Open Access Journals (Sweden)

    André Malbergier

    2004-03-01

    Full Text Available A pancreatite aguda é uma patologia grave e com considerável morbidade e mortalidade. Vários fatores são apontados como possíveis causas de pancreatite aguda. Neste relato, será apresentado um caso de pancreatite aguda com possível associação causal com um inibidor seletivo de recaptura de serotonina: sertralina. Após um mês de tratamento com sertralina, uma paciente do sexo feminino, 55 anos, desenvolveu forte dor abdominal e elevação da amilase sérica. Após internação e retirada da sertralina, seus sintomas remitiram e os níveis de amilase voltaram ao normal. Pela potencial gravidade do quadro e pelo amplo uso desta medicação, tal associação deve ser lembrada em investigações de casos de pancreatite aguda.Acute pancreatitis is a severe disease with considerable morbidity and mortality. Many risk factors are causally related to acute pancreatitis. In this report, a case of acute pancreatitis with possible causal relationship with the use of a selective serotonin reuptake inhibitor, sertraline, will be discussed. After one month of treatment with sertraline, a female patient, 55 years-old, developed a severe abdominal pain and showed a serum amylase elevation. She was admitted to the hospital and the use of sertraline was interrupted. After that, the symptoms remitted and the serum amylase level returned to normal. Because of the potential severity of this disease and the widespread use of sertraline, this association should be reminded when investigating possible causes for acute pancreatitis.

  8. MANOVA, LDA, and FA criteria in clusters parameter estimation

    Directory of Open Access Journals (Sweden)

    Stan Lipovetsky

    2015-12-01

    Full Text Available Multivariate analysis of variance (MANOVA and linear discriminant analysis (LDA apply such well-known criteria as the Wilks’ lambda, Lawley–Hotelling trace, and Pillai’s trace test for checking quality of the solutions. The current paper suggests using these criteria for building objectives for finding clusters parameters because optimizing such objectives corresponds to the best distinguishing between the clusters. Relation to Joreskog’s classification for factor analysis (FA techniques is also considered. The problem can be reduced to the multinomial parameterization, and solution can be found in a nonlinear optimization procedure which yields the estimates for the cluster centers and sizes. This approach for clustering works with data compressed into covariance matrix so can be especially useful for big data.

  9. Status and prospects of the FaCT project

    International Nuclear Information System (INIS)

    Nagaoki, Yoshihiro; Kikuchi, Shin; Ichimiya, Masakazu

    2008-01-01

    'Fast Reactor Cycle Technology Development (FaCT)' project has been conducted since 2006. In this project, design study and research and development (R and D) on innovative technologies for fast reactor (FR) cycle system are implemented in order to present the conceptual designs of commercial and demonstration facilities by 2015 and start operating demonstration fast reactor in 2025. The R and Ds has been stepped forward into the development stage to establish the realization of innovative technologies which bring excellent performance to fast reactor cycle system. The purpose of R and D by 2010 is to decide whether innovative technologies shall be adopted. So promoting R and D of FR, the project governance was organized. Furthermore, several possible R and D have been effectively carried out within the frameworks of international cooperation, such as Global Nuclear Energy Partnership (GNEP), Generation IV International Forum (GIF), and International Project on Innovative Nuclear Reactors and Fuel Cycles (INPRO). (author)

  10. Algunas observaciones sobre la apendicitis aguda en los niños

    Directory of Open Access Journals (Sweden)

    Luis Piñeros Suárez

    1940-03-01

    Full Text Available La apendicitis aguda en los niños, presenta actitudes particulares que diferencian de la apendicitis aguda del adulto y que vienen a formar grupos clínicos casi exclusivamente de la infancia. De una manera general, las formas más graves, las formas fulminantes de la apendicitis aguda se encuentran especialmente en la infancia y en estas formas graves llama poderosamente la atención, la falta de relación entre los signos clínicos observados y la importancia de las lesiones encontradas en el apéndice y el peritoneo, pues en los niños con signos de intensidad media y sin que se hayan presentado los síntomas que en el adulto caracterizan las formas graves de apendicitis, podemos encontrar en las operaciones practicadas en las primeras 24 a 36 horas, peritonitis generalizadas, formas de apendicitis gangrenosas, que no son frecuentes en el adulto y mucho menos en un lapso de tiempo tan corto.

  11. Infarto esplénico secundario a pancreatitis aguda Splenic infarction secondary to acute pancreatitis

    Directory of Open Access Journals (Sweden)

    J. J. Arenal Vera

    2008-05-01

    Full Text Available Fundamento y objetivo: la estrecha relación anatómica del páncreas con los vasos esplénicos y el bazo es responsable de complicaciones esplénicas en el curso de la pancreatitis aguda. El objetivo es presentar dos casos clínicos de pancreatitis aguda grave que sufrieron infarto esplénico como complicación de la enfermedad pancreática. Pacientes, participantes: en un periodo de tres meses, dos pacientes fueron diagnosticados de infarto esplénico secundario a pancreatitis aguda. En ambos casos el diagnóstico y seguimiento evolutivo del infarto esplénico se hizo a través de tomografía axial computerizada. Resultados: en el primer paciente, las imágenes muestran de forma inequívoca la afectación de la arteria esplénica por el proceso inflamatorio pancreático. En el segundo, no se pudo demostrar afectación de los vasos esplénicos, por lo que la única posible explicación etiológica es un incremento de coagulabilidad intravascular. Conclusiones: sería recomendable añadir las complicaciones esplénicas al conjunto de complicaciones graves extrapancreáticas de la pancreatitis aguda. La tomografía axial computerizada es de gran utilidad para la detección y seguimiento de las complicaciones esplénicas de la pancreatitis aguda.Background and objective: the close anatomic relationship of the pancreas with the splenic vessels and the spleen is responsible for splenic complications in the course of acute pancreatitis. Our objective was to report two cases of severe acute pancreatitis complicated by splenic infarction. Patients: in a three-month period of time two patients were diagnosed with splenic infarction secondary to acute pancreatitis. In both cases splenic infarction diagnosis and follow-up were carried out using computed tomography. Results: in the first case images clearly showed a narrowing of the splenic artery due to the inflammatory pancreatic condition. In the second case no involvement of the splenic vessels could

  12. Tratamiento quirúrgico de las colecciones agudas y crónicas del pericardio

    Directory of Open Access Journals (Sweden)

    Orestes Noel Mederos Curbelo

    Full Text Available Introducción: las colecciones agudas o crónicas del pericardio con frecuencia producen una compresión del corazón que en los casos crónicos conlleva invalidez y, en los agudos, peligro de muerte por taponamiento cardíaco. Objetivo: caracterizar a los pacientes intervenidos quirúrgicamente en el Hospital Universitario "Comandante Manuel Fajardo" entre 1995 y 2012 a causa de colecciones pericárdicas. Métodos: se realizó un estudio descriptivo transversal con los pacientes atendidos quirúrgicamente en dicha institución por colecciones del pericardio. Constituyeron el universo 24 pacientes: 22 con colecciones agudas y 2 con colecciones crónicas. Resultados: la causa más frecuente de los derrames agudos fue la pericarditis aguda idiopática (25 %. Las colecciones crónicas fueron por pericarditis fibrosa de causa idiopática en el 100 % de los enfermos. La intervención realizada fue la resección del pericardio y el drenaje de las colecciones agudas mediante toracotomía izquierda o por vía preperitoneal subxifoidea. En las colecciones de origen maligno se realizó la resección pericárdica con fines paliativos y, en los derrames por lesión traumática del corazón, la sutura de este órgano fue el tratamiento quirúrgico empleado en todos los casos. En las pericarditis constrictivas, la pericardiectomía radical fue el tratamiento empleado en el 100 % de los casos. Conclusiones: el tratamiento quirúrgico en las colecciones agudas y crónicas del pericardio permite drenar el contenido por una ventana pericárdica obtenida por toracoscopia o por vía preperitoneal subxifoidea, mientras que la toracotomía izquierda es útil en las emergencias. En los derrames crónicos con fibrosis y síntomas de insuficiencia cardíaca, la pericardiectomía radical mediante esternotomía media ofrece los mejores resultados.

  13. Intoxicaciones agudas graves en un servicio de medicina intensiva durante doce años

    Directory of Open Access Journals (Sweden)

    Palazón Sánchez C

    2000-01-01

    Full Text Available Fundamento: Conocer la epidemiología de las intoxicaciones agudas graves en un servicio de medicina intensiva y evaluar el pronóstico de la PCR y mortalidad asociada a los distintos tóxicos Métodos: Estudio retrospectivo realizado en el servicio de medicina intensiva polivalente de 10 camas, ubicado en un Hospital General de adultos. Período de estudio 12 años. Revisión de las historias clínicas de las personas ingresadas en el servicio de medicina intensiva por intoxicaciones agudas graves. Se recogieron datos demográficos, existencia de PCR al ingreso, necesidad de VM, complicaciones de las intoxicaciones agudas graves y mortalidad de la serie. Se realizó un análisis global y por año de estudio. El tratamiento estadístico de los datos se realizó con el paquete SPSS mediante la "t" de Student o la "chi" cuadrado, considerando valores significativos si p<0,05 Resultados: Se han incluido 233 sujetos, de los que 130 fueron varones. La estancia media fue de 4 días. El 63% de los pacientes fueron menores de 40 años (p<0,05. La intoxicación más frecuente fue la medicamentosa debida a un solo producto (72%. La supervivencia tras la PCR fue del 40% (4/10. La mortalidad global se situó en el 5,6% (n=13, habiendo precisado el 92% de los sujetos que posteriormente murieron, VM en algún momento de su ingreso en la unidad de cuidados intensivos. Conclusiones: En nuestro medio, la intoxicación más frecuente es la medicamentosa. La mortalidad se muestra dependiente del carácter de voluntariedad, pero independiente del tipo de tóxico (medicamentoso o no. La PCR asociada a las intoxicaciones agudas graves tiene, en nuestra serie, un mejor pronostico que la asociada a otras patologías. La VM asociada a las intoxicaciones agudas graves tiene una mortalidad baja (15,7%

  14. Does Fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials?

    DEFF Research Database (Denmark)

    Jensen, Charlotte Floridon; Jensen, Charlotte Harken; Thorsen, Poul

    2000-01-01

    Fetal antigen 1 (FA1) is a circulating EGF multidomain glycoprotein. FA1 and its membrane-associated precursor is defined by the mRNAs referred to as delta-like (dlk), preadipocyte factor 1 (pref-1) or zona glomerulosa-specific factor (ZOG). Using a polyclonal antibody recognising both forms......, the localisation of FA1/dlk was analysed in embryonic and fetal tissues between week 5 to 25 of gestation and related to germinal origin and development. FA1 was observed in endodermally derived hepatocytes, glandular cells of the pancreas anlage, and in respiratory epithelial cells. FA1 was also present...... in mesodermally derived cells of the renal proximal tubules, adrenal cortex, Leydig and Hilus cells of the testes and ovaries, fetal chondroblasts, and skeletal myotubes. Ectodermally derived neuro- and adenohypophysial cells, cells in the floor of the 3rd ventricle and plexus choroideus were also FA1 positive...

  15. Effect of hyperthermia on experimental acute pancreatitis Efeito da hipertermia na pancreatite aguda experimental

    Directory of Open Access Journals (Sweden)

    José Luiz Jesus de Almeida

    2006-12-01

    Full Text Available BACKGROUD: Recent studies indicate that hyperthermia can change inflammatory mechanisms and protect experimental animals from deleterious effects of secretagogue-induced acute pancreatitis AIM: To evaluate the effects of hyperthermia post-treatment on cerulein-induced acute pancreatitis in rats METHODS: Twenty animals were divided in two groups: group I (n = 10, rats with cerulein-induced acute pancreatitis undergone hyperthermia, and group II (n = 10, animals with cerulein-induced acute pancreatitis that were kept normothermic. In all groups, amylase serum levels, histologic damage, vascular permeability and pancreatic water content were assessed. Acute pancreatitis was induced by administration of two cerulein injections (20 mcg/kg. A single dose of Evans' blue dye was administered along with the second dose of cerulein. All animals also received a subcutaneous injection of saline solution. After this process, animals undergone hyperthermia were heated in a cage with two 100 W lamps. Body temperature was increased to 39.5ºC and maintained at that level for 45 minutes. Normothermia rats were kept at room temperature in a second cage RESULTS: Control animals had typical edema, serum amylase activity and morphologic changes of this acute pancreatitis model. Hyperthermia post-treatment ameliorated the pancreatic edema, whereas the histologic damage and the serum amylase level remained unchanged CONCLUSIONS: The findings suggest a beneficial effect of the thermal stress on inflammatory edema in experimental acute pancreatitis.RACIONAL: Estudos recentes indicam que a hipertermia pode modificar mecanismos inflamatórios e proteger animais experimentais dos efeitos deletérios da pancreatite aguda induzida por secretagogos OBJETIVO: Avaliar a eficácia da hipertermia como tratamento da pancreatite aguda induzida por ceruleína em ratos MÉTODOS: Vinte animais foram divididos em dois grupos: grupo I (n = 10, ratos com pancreatite aguda induzida por

  16. Effect of façade systems on the performance of cooling ceilings: In situ measurements

    Directory of Open Access Journals (Sweden)

    Katharina Eder

    2015-03-01

    Full Text Available This article presents an innovative façade system designed to increase the thermal comfort inside an office room and to enhance the cooling capacity of the suspended cooling ceiling. A series of measurements is conducted in an existing office building with different façade systems (i.e., a combination of glazing and shading. An innovative façade system is developed based on this intensive set of measurements. The new system enhances the thermal comfort and cooling capacity of the suspended cooling ceiling. The main usage of the new system is the refurbishment and improvement of existing façade systems.

  17. Microcristais biliares na pancreatite aguda idiopática: indício para etiologia biliar oculta subjacente

    Directory of Open Access Journals (Sweden)

    CHEBLI Júlio Maria Fonseca

    2000-01-01

    Full Text Available As principais causas de inflamação pancreática no mundo são a litíase biliar e o alcoolismo crônico. Admite-se que 10 a 30% das pancreatites agudas sejam idiopáticas. Sugere-se que parte destas são causadas por microlitíase ou barro biliar, identificados pela presença de microcristais no sedimento biliar. Neste estudo, realizou-se análise microscópica da bile obtida por colangiopancreatografia endoscópica, em pacientes com pancreatite aguda idiopática, pancreatite aguda biliar e pancreatite crônica alcoólica - 20 em cada grupo. Pacientes com pancreatite aguda idiopática e microcristais na bile foram submetidos a colecistectomia. Naqueles inaptos à cirurgia efetuou-se esfincterotomia endoscópica ou tratamento com ácido ursodesoxicólico. Pacientes com pancreatite aguda idiopática sem cristais não receberam tratamento específico. A prevalência de microcristais biliares em pacientes com pancreatite aguda idiopática (75% e pancreatite aguda biliar (90% foi significativamente maior que naqueles com pancreatite crônica alcoólica (15%. A detecção de microcristais apresentou sensibilidade de 90%, especificidade de 85%, valor preditivo positivo de 85,7%, valor preditivo negativo de 89,4% e acurácia de 87,5% em identificar pancreatite de origem biliar. Nos pacientes com pancreatite aguda idiopática recurrente, cursando com microcristais, houve redução significante dos episódios de pancreatite após tratamento específico. No seguimento deste grupo durante 23,3 meses, recidiva ocorreu apenas naqueles que apresentavam "fator biliar persistente" (coledocolitíase ou microcristais. Todos os pacientes com pancreatite aguda idiopática submetidos a colecistectomia apresentavam colecistite crônica, e microlitíase foi observada em um paciente. No seguimento ultra-sonográfico, colelitíase foi detectada em um dos casos. No subgrupo de cinco pacientes com pancreatite aguda idiopática sem microcristais houve uma recidiva. Estudo

  18. Fatores preditivos de coledocolitíase em doentes com pancreatite aguda biliar Predictors of choledocholithiasis in patients sustaining acute biliary pancreatitis

    Directory of Open Access Journals (Sweden)

    José Gustavo Parreira

    2004-12-01

    Full Text Available OBJETIVO: Avaliar o papel da fosfatase alcalina (FA, gama glutamiltransferase (gamaGT e ultra-sonografia (US como fatores preditivos de coledocolitíase em doentes com pancreatite aguda biliar (PAB. MÉTODOS: Os dados foram coletados prospectivamente durante um período de 31 meses. Quarenta doentes foram incluídos, sendo 30 mulheres, com média etária de 49 + 16 anos. Foram registrados os dados de todos os doentes com pancreatite aguda biliar. Aqueles doentes ictéricos e com a forma grave da doença foram excluídos. As dosagens de FA e GGT, assim como a US, eram realizadas na admissão e 48 horas antes da cirurgia. Todos os pacientes foram submetidos à colangiografia intra-operatória (CIO ou à colangiografia retrógrada endoscópica (CPRE pré-operatória, que era definida baseada na probabilidade de coledocolitíase. Com o intuito de identificar os indicadores de coledocolitíase, as variáveis foram comparadas entre os pacientes com ou sem coledocolitíase. Os testes t de Student, Qui-quadrado e Fisher foram empregados para a análise estatística, considerando-se pBACKGROUND: To assess the role of alkaline phosphatase (AP, gamil-glutamyltransferase (gammaGT and abdominal ultrasound (US as predictors of choledocholithiasis in patients sustaining acute biliary pancreatitis. METHODS: Data was prospectively collected during a period of 31 months. Forty patients were included, 30 were female and the mean age was 49 + 16. All patients sustaining acute biliary pancreatitis were enrolled. Patients with clinical jaundice and severe pancreatitis were excluded. Serum content of AP and gGT as well as US were assessed at admission and 48 hours before cholecistectomy. All patients underwent intra-operative cholangiography (IOC or pre-operative endoscopic retrograde cholangiography (ERCP, which was indicated based on the odds of choledocholithiasis. In order to identify the predictors of choledocholithiasis, variables were compared between patients

  19. Efek Beauveria bassiana pada Anopheles maculatus Fase Aquatik di Laboratorium

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    Bina Ikawati

    2017-07-01

    Full Text Available AbstractBeauveria bassiana can be used both as for controlling agricultural insect and protecting health. Thisstudy aims to examine the effects of aquatic phase of B. bassiana on An. maculatus in the laboratory.Samples were eggs and larvae of An. maculatus reared from Banjarnegara colony. Eggs and instarlarvae II, III and IV and their control which consisted of 10 larvae/eggs were replicated six times andcontacted to B. bassiana spores for 15 minutes and then transferred to aquades to be maintained forobservation, in every 24 hours as long as 192 hours (8 days. Probit analysis found that applicationof B. bassiana caused damage of external coat of eggs and inhibited >60% of unhatched eggs. Lethaldosage was dosage spores of 1,713x107 (16 days, whereas the lethal dose required to make 50% ofunperached eggs is a dose of spore concentration of 1,361x107 (11.6 days. Higher concentrationswill be needed to know the faster effects B bassiana on An. maculatus larvae or eggs.Key words: Beauveria bassiana, Anopheles maculatus, aquatic phase, laboratory AbstrakBeauveria bassiana dapat digunakan baik sebagai pengendali serangga pertanian maupun kesehatan.Penelitian ini bertujuan mengkaji efek B. bassiana terhadap An. maculatus pada fase akuatik dilaboratorium. Sampel uji berupa telur dan larva An. maculatus dari koloni Banjarnegara. Telur danlarva instar II,III dan IV serta kontrol masing-masing sebanyak 10 ekor/butir dengan replikasi 6 kalidikontakkan dengan spora B. bassiana selama 15 menit dan selanjutnya dipindahkan ke aquadesuntuk dipelihara untuk dilakukan pengamatan, pengamatan dengan mikroskop compound terutamapada larva yang lemah/mati setiap 24 jam selama 192 jam (8 hari. Analisis probit membuktikanbahwa aplikasi B. bassiana pada telur menimbulkan efek kerusakan pada lapisan luar telur diketahuidari pengamatan dengan mikroskop serta mampu menghambat >60% telur tidak menetas. Simulasidengan análisis probit menunjukkan lethal dose yang dibutuhkan

  20. Uji Klinik Fase II Ramuan Jamu sebagai Pelindung Fungsi Hati

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    zuraida - zulkarnain

    2017-07-01

    Full Text Available AbstractThe human liver is susceptible to interference due to its complex function. The development ofhepatoprotective from jamu formula is still needed as to produce more effective, cheaper andsafer hepatoprotective. The result of previous study showed that the hepatoprotective from jamuformula was safe and efficacious. This phase 2 trial was conducted to evaluate the efficacy andsafety of hepatoprotective from jamu formula which consists of Curcuma longa rhizomes, Curcumaxanthorrhiza rhizomes, and Taraxacum officinale leaves. The design was open label randomizedclinical trial with silimarin as a comparison for 42 days intervention. Two hundreds of humansubjects participated in this study. The trial held in 2015 and involved 50 physician members ofSaintifikasi Jamu Network at several regencies in Indonesia. The parameters for assessing efficacywere SGPT, SGOT and as for safety were routine blood, urea, and creatinine. Clinical symptoms andpossible side effects were also observed. The results showed that the jamu formula can reduce theaverage value of SGPT and SGOT equal to silimarin. Jamu formula can relieve clinical symptomsarising from liver function disruption, and it is safe, it does not alter kidney function, hemoglobin,leukocyte count and platelet count in its use for 42 days.Keywords: hepatoprotective, Saintifikasi Jamu, Curcuma longa, Curcuma AbstrakHati mudah mengalami gangguan disebabkan fungsinya yang kompleks. Saat ini masih diperlukanpengembangan ramuan jamu untuk melindungi dan memperbaiki sel-sel hati (hepatoprotektor yanglebih efektif, murah dan aman. Hasil penelitian observasi klinik terdahulu menunjukkan bahwaformula jamu untuk hepatoprotektor aman dan berkhasiat sehingga dilanjutkan dengan uji klinik fase2. Tujuan uji ini untuk menilai khasiat dan keamanan ramuan jamu sebagai hepatoprotektor dengankomposisi rimpang temulawak, rimpang kunyit, dan daun jombang. Rancangan uji adalah open labelrandomised clinical trial dengan

  1. Fase gametofítica del helecho Microgramma nitida (Polypodiaceae

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    Ma. del Rosario Ramírez

    1998-09-01

    Full Text Available Se describe la fase gametofítica del helecho Microgramma nitid con esporas de Veracruz, México (siembra promedio 40 esporas/ cm². La morfogénesis se caracteriza por: germinación tipo Vittaria, un filamento inicial de seis células protálicas; gametofitos jóvenes espatulados que se transforman en gametofitos adultos cordiformes-alargados, con márgenes ondulados y tricomas unicelulares-capitados en los margenes y en las superficies; aparición de una célula meristemática obcónica apical, que es reemplazada rápidamente por un meristemo pluricelular. Los anteridios y arquegonios son del tipo usual de las Polypodiaceae s.str. El desarrollo protálico es del tipo Drynaria. Ocho meses después de la siembra apareció la primera hoja del esporofito; ésta es espatulada, con márgenes lisos y una hilera de células aclorofílicas, tricomas pluricelulares, bifurcados y estomas anomocíticos. Las células epidérmicas de la hoja del esporofito tienen paredes laterales onduladas en las superficies dorsal y ventral.The development of the gametophytic phase of Microgramma nitida is described based on spore samples that was obtained of fertil specimens gathered on Veracruz State, Mexico. The spore sowing density was 40 spores/cm2 ; it is characterized by Vittaria-type germination of the spore, a germinal filament of six cells; young gametophytes are naked, spathulated and later are transformed in cordate-elongated adult gametophytes with wavy borders; marginal, superficial capitated, unicellular hairs; the meristematic cell is wedge-shaped and is quickly replaced by a pluricellular meristem. The antheridia and archegonia are of the usual Polypodiaceae s. str.type. Prothallial development is thus of the Drynaria-type. The first leaf of the sporophyte appeared eight months after spore sowing. The leaf is spathulated, with smooth borders and the margin has a row of cells without chlorophyll; bifurcated and pluricellular hairs; anomocytic stomata; the

  2. The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway.

    Science.gov (United States)

    Polito, David; Cukras, Scott; Wang, Xiaozhe; Spence, Paige; Moreau, Lisa; D'Andrea, Alan D; Kee, Younghoon

    2014-03-07

    Fanconi anemia (FA) is a genome instability syndrome characterized by bone marrow failure and cellular hypersensitivity to DNA cross-linking agents. In response to DNA damage, the FA pathway is activated through the cooperation of 16 FA proteins. A central player in the pathway is a multisubunit E3 ubiquitin ligase complex or the FA core complex, which monoubiquitinates its substrates FANCD2 and FANCI. FANCE, a subunit of the FA core complex, plays an essential role by promoting the integrity of the complex and by directly recognizing FANCD2. To delineate its role in substrate ubiquitination from the core complex assembly, we analyzed a series of mutations within FANCE. We report that a phenylalanine located at the highly conserved extreme C terminus, referred to as Phe-522, is a critical residue for mediating the monoubiquitination of the FANCD2-FANCI complex. Using the FANCE mutant that specifically disrupts the FANCE-FANCD2 interaction as a tool, we found that the interaction-deficient mutant conferred cellular sensitivity in reconstituted FANCE-deficient cells to a similar degree as FANCE null cells, suggesting the significance of the FANCE-FANCD2 interaction in promoting cisplatin resistance. Intriguingly, ectopic expression of the FANCE C terminus fragment alone in FA normal cells disrupts DNA repair, consolidating the importance of the FANCE-FANCD2 interaction in the DNA cross-link repair.

  3. The Carboxyl Terminus of FANCE Recruits FANCD2 to the Fanconi Anemia (FA) E3 Ligase Complex to Promote the FA DNA Repair Pathway*

    Science.gov (United States)

    Polito, David; Cukras, Scott; Wang, Xiaozhe; Spence, Paige; Moreau, Lisa; D'Andrea, Alan D.; Kee, Younghoon

    2014-01-01

    Fanconi anemia (FA) is a genome instability syndrome characterized by bone marrow failure and cellular hypersensitivity to DNA cross-linking agents. In response to DNA damage, the FA pathway is activated through the cooperation of 16 FA proteins. A central player in the pathway is a multisubunit E3 ubiquitin ligase complex or the FA core complex, which monoubiquitinates its substrates FANCD2 and FANCI. FANCE, a subunit of the FA core complex, plays an essential role by promoting the integrity of the complex and by directly recognizing FANCD2. To delineate its role in substrate ubiquitination from the core complex assembly, we analyzed a series of mutations within FANCE. We report that a phenylalanine located at the highly conserved extreme C terminus, referred to as Phe-522, is a critical residue for mediating the monoubiquitination of the FANCD2-FANCI complex. Using the FANCE mutant that specifically disrupts the FANCE-FANCD2 interaction as a tool, we found that the interaction-deficient mutant conferred cellular sensitivity in reconstituted FANCE-deficient cells to a similar degree as FANCE null cells, suggesting the significance of the FANCE-FANCD2 interaction in promoting cisplatin resistance. Intriguingly, ectopic expression of the FANCE C terminus fragment alone in FA normal cells disrupts DNA repair, consolidating the importance of the FANCE-FANCD2 interaction in the DNA cross-link repair. PMID:24451376

  4. Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2

    Energy Technology Data Exchange (ETDEWEB)

    Godthelp, Barbara C. [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Buul, Paul P.W. van [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Jaspers, Nicolaas G.J. [Department of Cell Biology and Genetics, Erasmus University, P.O. Box 1738, 3000 DR Rotterdam (Netherlands); Elghalbzouri-Maghrani, Elhaam [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Duijn-Goedhart, Annemarie van [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands); Arwert, Fre [Department of Clinical Genetics and Human Genetics, Free University Medical Center, Amsterdam (Netherlands); Joenje, Hans [Department of Clinical Genetics and Human Genetics, Free University Medical Center, Amsterdam (Netherlands); Zdzienicka, Malgorzata Z. [Department of Toxicogenetics, Leiden University Medical Center, Building 2, Postzone S-6-P, P.O. Box 9600, 2300 RC, Leiden (Netherlands) and Department of Molecular Cell Genetics, Collegium Medicum, N.Copernicus University, Bydgoszcz (Poland)]. E-mail: M.Z.Zdzienicka@LUMC.nl

    2006-10-10

    Fanconi anemia (FA) is an inherited cancer-susceptibility disorder, characterized by genomic instability and hypersensitivity to DNA cross-linking agents. The discovery of biallelic BRCA2 mutations in the FA-D1 complementation group allows for the first time to study the characteristics of primary BRCA2-deficient human cells. FANCD1/BRCA2-deficient fibroblasts appeared hypersensitive to mitomycin C (MMC), slightly sensitive to methyl methane sulfonate (MMS), and like cells derived from other FA complementation groups, not sensitive to X-ray irradiation. However, unlike other FA cells, FA-D1 cells were slightly sensitive to UV irradiation. Despite the observed lack of X-ray sensitivity in cell survival, significant radioresistant DNA synthesis (RDS) was observed in the BRCA2-deficient fibroblasts but also in the FANCA-deficient fibroblasts, suggesting an impaired S-phase checkpoint. FA-D1/BRCA2 cells displayed greatly enhanced levels of spontaneous as well as MMC-induced chromosomal aberrations (Canada), similar to cells deficient in homologous recombination (HR) and non-D1 FA cells. In contrast to Brca2-deficient rodent cells, FA-D1/BRCA2 cells showed normal sister chromatid exchange (SCE) levels, both spontaneous as well as after MMC treatment. Hence, these data indicate that human cells with biallelic BRCA2 mutations display typical features of both FA- and HR-deficient cells, which suggests that FANCD1/BRCA2 is part of the integrated FA/BRCA DNA damage response pathway but also controls other functions outside the FA pathway.

  5. Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2

    International Nuclear Information System (INIS)

    Godthelp, Barbara C.; Buul, Paul P.W. van; Jaspers, Nicolaas G.J.; Elghalbzouri-Maghrani, Elhaam; Duijn-Goedhart, Annemarie van; Arwert, Fre; Joenje, Hans; Zdzienicka, Malgorzata Z.

    2006-01-01

    Fanconi anemia (FA) is an inherited cancer-susceptibility disorder, characterized by genomic instability and hypersensitivity to DNA cross-linking agents. The discovery of biallelic BRCA2 mutations in the FA-D1 complementation group allows for the first time to study the characteristics of primary BRCA2-deficient human cells. FANCD1/BRCA2-deficient fibroblasts appeared hypersensitive to mitomycin C (MMC), slightly sensitive to methyl methane sulfonate (MMS), and like cells derived from other FA complementation groups, not sensitive to X-ray irradiation. However, unlike other FA cells, FA-D1 cells were slightly sensitive to UV irradiation. Despite the observed lack of X-ray sensitivity in cell survival, significant radioresistant DNA synthesis (RDS) was observed in the BRCA2-deficient fibroblasts but also in the FANCA-deficient fibroblasts, suggesting an impaired S-phase checkpoint. FA-D1/BRCA2 cells displayed greatly enhanced levels of spontaneous as well as MMC-induced chromosomal aberrations (Canada), similar to cells deficient in homologous recombination (HR) and non-D1 FA cells. In contrast to Brca2-deficient rodent cells, FA-D1/BRCA2 cells showed normal sister chromatid exchange (SCE) levels, both spontaneous as well as after MMC treatment. Hence, these data indicate that human cells with biallelic BRCA2 mutations display typical features of both FA- and HR-deficient cells, which suggests that FANCD1/BRCA2 is part of the integrated FA/BRCA DNA damage response pathway but also controls other functions outside the FA pathway

  6. Insuficiência respiratória aguda como primeira manifestação de esclerose lateral amiotrófica: dois casos clínicos

    Directory of Open Access Journals (Sweden)

    Susana Moreira

    2004-11-01

    Full Text Available RESUMO: A esclerose lateral amiotrófica (ELA é uma doença neuromuscular rapidamente progressiva que envolve todos os grupos musculares com excepção dos músculos extra-oculares e dos esfíncteres. A maior causa de morbilidade e mortalidade são as complicações respiratórias que surgem habitualmente numa fase tardia da história natural da doença. Num número reduzido de casos, a ELA tem como manifestação inicial a insuficiência respiratória aguda.Os autores apresentam 2 casos clínicos de doentes internados num Serviço de pneumologia, sem doença neuromuscular prévia conhecida, com o diagnóstico de insuficiência respiratória aguda de etiologia desconhecida e que se revelaram ser ELA.A análise dos casos discutidos, e dos que estão já publicados na literatura, sugere que o aparecimento de insuficiência respiratória aguda em doentes sem história prévia de patologia pulmonar e/ou cardíaca, especialmente na 5.ª e 6.ª décadas de vida, deve alertar para a ELA como hipótese diagnóstica.REV PORT PNEUMOL 2004; X (6: 499-504 ABSTRACT: Amyotrophic lateral sclerosis (ALS is a fast progressing neuromuscular disease that affects all but the extrinsic muscles of the eye and sphincters. The main cause of morbidity and mortality are the respiratory complications that usually start in a late stage of the disease’s natural history. In a small number of cases acute respiratory failure is the initial manifestation of the disease.The authors present 2 case studies admitted to a pulmonary department, without previously known neuromuscular disease, with the diagnosis of acute respiratory failure of unknown ethiology and that were later shown to be cases of ALS.Analysis of the cases presented here, and those already published in the literature, suggests that the occurrence of acute respiratory failure in patients without a previous history of pulmonary and

  7. Comportamento da síndrome coronariana aguda: resultados de um registro brasileiro

    Directory of Open Access Journals (Sweden)

    Leopoldo Soares Piegas

    2013-06-01

    Full Text Available FUNDAMENTO: O Brasil carece de registros multicêntricos publicados de síndrome coronariana aguda. OBJETIVO: O Registro Brasileiro de Síndrome Coronariana Aguda é um estudo multicêntrico nacional com objetivo de apresentar dados representativos das características clínicas, e manejo e evolução hospitalares dessa síndrome. MÉTODOS: Participaram 23 hospitais de 14 cidades. Foram elegíveis pacientes que se apresentaram com suspeita de síndrome coronariana aguda nas primeiras 24 horas, com quadro clínico sugestivo, associado a alterações eletrocardiográficas compatíveis e/ou marcadores de necrose. O seguimento foi realizado até o óbito ou a alta hospitalar. RESULTADOS: Entre os anos de 2003 e 2008, foram incluídos 2.693 pacientes com diagnóstico de síndrome coronariana aguda, sendo 864 (32,1% mulheres. O diagnóstico final foi de angina instável para 1.141 (42,4% pacientes, com mortalidade de 3,06% deles; de infarto agudo do miocárdio sem supradesnível de ST para 529 (19,6% pacientes, com mortalidade de 6,8% deles; e de infarto agudo do miocárdio com supradesnível de ST para 950 (35,3% pacientes, com mortalidade de 8,1% deles; tiveram diagnóstico não confirmado 73 (2,7% pacientes, com mortalidade de 1,36% deles. A mortalidade global foi de 5,53%. O modelo de regressão logística múltipla identificou o gênero feminino (OR=1,45, o diabetes melito (OR=1,59, o índice de massa corporal (OR=1,27 e a intervenção coronariana percutânea (OR=0,70 como fatores de risco de óbito, para demografia e intervenções. Um modelo para óbito por complicações maiores identificou choque cardiogênico/Edema Agudo de Pulmão (OR=4,57, reinfarto (OR=3,48, acidente vascular cerebral (OR=21,56, sangramento grave (OR=3,33, parada cardiorrespiratória (OR=40,27 e classe funcional de Killip (OR=3,37. CONCLUSÃO: Os dados do Registro Brasileiro de Síndrome Coronariana Aguda não diferem de outros coletados fora do país. Seus achados poder

  8. FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Abdullah Mahmood; Singh, Thiyam Ramsing [Division of Experimental Hematology and Cancer Biology, Cincinnati Children' s Research Foundation, Cincinnati Children' s Hospital Medical Center, Cincinnati, OH 45229 (United States); Meetei, Amom Ruhikanta, E-mail: Ruhikanta.Meetei@cchmc.org [Division of Experimental Hematology and Cancer Biology, Cincinnati Children' s Research Foundation, Cincinnati Children' s Hospital Medical Center, Cincinnati, OH 45229 (United States); Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 (United States)

    2009-07-31

    Fanconi anemia (FA) is a rare autosomal recessive or X-linked disorder characterized by aplastic anemia, cancer susceptibility and cellular sensitivity to DNA-crosslinking agents. Eight FA proteins (FANCA, -B, -C, -E, -F, -G, -L and -M) and three non-FA proteins (FAAP100, FAAP24 and HES1) form the FA nuclear core complex that is required for monoubiquitination of the FANCD2-FANCI dimer upon DNA damage. The other three FA proteins, FANCD1/BRCA2, FANCJ/BACH1/BRIP1 and FANCN/PALB2, act in parallel or downstream of the FANCD2-FANCI dimer. Despite the isolation and characterization of several FA proteins, the mechanism by which these proteins protect cells from DNA interstrand crosslinking agents has been unclear. This is because a majority of the FA proteins lack any recognizable functional domains that can provide insight into their function. The recently discovered FANCM (Hef) and FANCJ (BRIP1/BACH1) proteins contain helicase domains, providing potential insight into the role of FA proteins in DNA repair. FANCM with its partner, FAAP24, and FANCJ bind and metabolize a variety of DNA substrates. In this review, we focus on the discovery, structure, and function of the FANCM-FAAP24 and FANCJ proteins.

  9. FANCM-FAAP24 and FANCJ: FA proteins that metabolize DNA

    International Nuclear Information System (INIS)

    Ali, Abdullah Mahmood; Singh, Thiyam Ramsing; Meetei, Amom Ruhikanta

    2009-01-01

    Fanconi anemia (FA) is a rare autosomal recessive or X-linked disorder characterized by aplastic anemia, cancer susceptibility and cellular sensitivity to DNA-crosslinking agents. Eight FA proteins (FANCA, -B, -C, -E, -F, -G, -L and -M) and three non-FA proteins (FAAP100, FAAP24 and HES1) form the FA nuclear core complex that is required for monoubiquitination of the FANCD2-FANCI dimer upon DNA damage. The other three FA proteins, FANCD1/BRCA2, FANCJ/BACH1/BRIP1 and FANCN/PALB2, act in parallel or downstream of the FANCD2-FANCI dimer. Despite the isolation and characterization of several FA proteins, the mechanism by which these proteins protect cells from DNA interstrand crosslinking agents has been unclear. This is because a majority of the FA proteins lack any recognizable functional domains that can provide insight into their function. The recently discovered FANCM (Hef) and FANCJ (BRIP1/BACH1) proteins contain helicase domains, providing potential insight into the role of FA proteins in DNA repair. FANCM with its partner, FAAP24, and FANCJ bind and metabolize a variety of DNA substrates. In this review, we focus on the discovery, structure, and function of the FANCM-FAAP24 and FANCJ proteins.

  10. 3D adaptable building skin : an invention for freedom in shape of façades

    NARCIS (Netherlands)

    Suma, A.B.

    2006-01-01

    This paper sets out to develop a principle on which a façade element can be deformed in shape. By using a flexible structure with cables, small bars and inflatable tubes, which together form a woven pattern, a 3D freedom of deformability results. The shape of the façade element can be manipulated

  11. High-intensity running in English FA Premier League soccer matches

    DEFF Research Database (Denmark)

    Bradley, Paul S.; Sheldon, William; Wooster, Blake

    2009-01-01

    The aims of this study were to (1) determine the activity profiles of a large sample of English FA Premier League soccer players and (2) examine high-intensity running during elite-standard soccer matches for players in various playing positions. Twenty-eight English FA Premier League games were...

  12. TOXICIDAD AGUDA DE Aleurites moluccana POR VIA ORAL EN RATAS SPRAGUE-DAWLEY

    Directory of Open Access Journals (Sweden)

    Laura Rocío Orellana-Cuéllar

    2014-12-01

    Full Text Available Objetivo: Determinar la toxicidad aguda por Aleurites moluccana por administración oral en ratas Sprague-Dawley. Metodología: Estudio experimental realizado en el Instituto de Patología de la Facultad de Medicina-UNMSM. Se usaron treinta ratas Sprague-Dawley, hembras y machos, de 6 semanas de edad. Se formaron aleatoriamente tres grupos de diez ratas: grupo A1, recibió 8,2 mg/Kg de peso de A. moluccana; grupo  A2, recibió 2000 mg/Kg de peso de A. moluccana; grupo control, recibió agua ad libitum. Se evaluaron los signos clínicos de toxicidad, los pesos, variables bioquímicas y las características histopatológicas de hígado, riñón, corazón, intestino, bazo y gónadas. Se consideró significativo un p0,05. Los grupos  A1 y A2 presentaron signos clínicos de toxicidad y la muerte de tres ratas; células hepáticas binucleadas y regenerativas en el hígado; y hemorragia glomerular en el riñón. Conclusiones: Las variables clínicas e histopatológicas en hígado y riñón demostraron que la Aleurites moluccana produce toxicidad aguda, las variables bioquímicas no demostraron este efecto. Palabras Claves: Aleurites moluccana, Toxicidad aguda, Ratas Sprague-Dawley.

  13. Síndrome coronariana aguda em paciente jovem com sintomas atípicos

    Directory of Open Access Journals (Sweden)

    Gustavo Daher

    2012-08-01

    Full Text Available O diagnóstico da dor torácica aguda no setor de emergência pode ser difícil e desafiador, incluindo diversos diagnósticos diferenciais, dentre eles: causas benignas a causas potencialmente fatais. O diagnóstico na maioria das vezesé estabelecido através do quadro clínico e de exames complementares como: marcadores de necrose miocárdica, eletrocardiograma e radiografia de tórax.A angiotomografia coronariana tem sido utilizada nos casos de dor torácica aguda com baixa ou intermediária probabilidade de síndrome coronariana aguda, permitindo sua exclusão e conseqüente alta precoce dos pacientes. Apresentamosrelato de caso de uma paciente jovem com dor precordial atípica e marcadores de necrose miocárdica discretamente elevados. Considerando-se a epidemiologia e o quadro clínico da paciente, foi feita hipótese diagnóstica inicial de miocardite. A angiotomografia cardíaca com pesquisa de realce tardiofoi solicitada. Apesar do escore de cálcio ter sido zero, foi diagnosticada lesão estenosante grave no terço médio da artéria coronária descendente anterior com realce tardio na parede anterior do ventrículo esquerdo, compatível comnecrose miocárdica. A paciente foi submetida a cateterismo com angioplastia da lesão.

  14. Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover

    DEFF Research Database (Denmark)

    Abdallah, Basem M; Bay-Jensen, Anne-Christine; Srinivasan, Bhuma

    2011-01-01

    We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s......-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n = 100) and a group of postmenopausal women, where half had received...... estrogen-replacement therapy (ERT, n = 166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p ...

  15. Pancreatitis aguda por hipertrigliceridemia severa: reporte de caso y revisión de la literatura

    OpenAIRE

    Herrera Del Águila, Dwight Denis; Garavito Rentería, Jorge; Linarez Medina, Karen; Lizarzaburu Rodríguez, Víctor

    2015-01-01

    La pancreatitis aguda por hipertrigliceridemia se presenta en aproximadamente 1-4 % de los casos, es la tercera causa de pancreatitis luego de la etiología biliar y alcohólica. La hipertrigliceridemia puede ser producida por causas primarias asociadas a trastornos genéticos en el metabolismo de los lípidos, y por casusas secundarias. Se presenta el caso de un paciente varón de 32 años de edad, natural de Huancayo, con antecedentes de diabetes mellitus tipo 2, dislipidemia mixta severa con hip...

  16. Sarcoidosis aguda: Variante de Síndrome de Löfgren sin eritema nodoso

    OpenAIRE

    Pérez, Gerardo; Facal, Jorge

    2014-01-01

    El síndrome de Löfgren, es una variante aguda de la sarcoidosis, que se caracteriza por fiebre, eritema nodoso, adenomegalias hiliares pulmonares y artritis. En general, tiene un curso benigno y autolimitado, que contrasta con las formas crónicas que requieren uso de corticoides y tienen tendencia a la recidiva. Se describe aquí el caso clínico de un paciente joven, de sexo masculino, con artritis pero sin eritema nodoso, lo que dificultó el planteo diagnóstico de síndrome de Löfgren. Se real...

  17. Inmunofenotipos aberrantes en leucemias agudas en una población hospitalaria de Buenos Aires

    Directory of Open Access Journals (Sweden)

    Viviana Novoa

    2013-02-01

    Full Text Available La citometría de flujo multiparamétrica es el método de elección para la caracterización inmunofenotípica de las células hematopoyéticas clonales presentes en los distintos procesos leucémicos agudos. El objetivo fue analizar la expresión de antígenos de membrana y evaluar la presencia de fenotipos aberrantes en los blastos de pacientes con diagnóstico de leucemia aguda, que permiten el monitoreo de la respuesta al tratamiento. Se revisaron los inmunofenotipos de 364 muestras de pacientes adultos derivadas a nuestro laboratorio en un período de 7 años. El inmunofenotipo se realizó por citometría de flujo con un amplio panel de anticuerpos monoclonales con el que se evaluó la expresión de antígenos de linaje linfoide, mieloide y también antígenos de maduración. De las 364 muestras estudiadas, 60.2% presentaron un fenotipo compatible con leucemia mieloide aguda (LMA, 28.8% con leucemia linfoblástica B (LLA-B, 6.6% con leucemia linfoblástica T (LLA-T y 4.4% con leucemias agudas poco frecuentes. La presencia de fenotipos aberrantes se observó en 89% de los casos, los fenotipos aberrantes identificados fueron: 1 infidelidad de linaje: LMA (54%, LLA-B (40%, LLA-T (29%; 2 ausencia de expresión antigénica: LMA (21%, LLA-B (35%, LLA-T (70%; 3 alteración de la expresión antigénica: LMA (67%, LLA-B (66%, LLA-T (84%; 4 asincronismo madurativo: LMA (26%, LLA-B (37% y 5 fenotipo ectópico: LLA-T 96%. El análisis por citometría de flujo multiparamétrica de las leucemias agudas permitió la identificación de fenotipos aberrantes en la mayoría de nuestros pacientes, que son de utilidad para el monitoreo de la respuesta al tratamiento.

  18. Infecciones respiratorias agudas en los niños. Posibles medidas de control

    OpenAIRE

    Mohs Villalta, Edgar

    1985-01-01

    Artículo científico -- Universidad de Costa Rica. Instituto de Investigaciones en Salud, 1985 Las infecciones respiratorias agudas que representan el 50% aproximadamente, de los casos de enfermedades que deben notificarse a las autoridades y de las consultas pediátricas de pacientes ambulatorios en los países en desarrollo, son también una de las principales causas de las enfermedades contraídas en los hospitales y de mortalidad por enfermedades nosocomiales. En 1982, por *mph:), fueron la...

  19. El problema Patogénico de las Pancreatitis Agudas. Lesiones producidas por la Etionina.

    OpenAIRE

    Pera Blanco-Morales, Cristóbal

    2016-01-01

    Cuando en el año 1952 realizamos una extensa revisión del problema de la necrosis aguda del páncreas, conveníamos en que eran tres las razones que justifican el gran interés que el estudio de esta afección conserva en la actualidad: a) Las dudas existentes acerca de su etiología y patogénesis. b) La extraordinaria gravedad del proceso que conduce a la muerte en una elevada proporción de casos. c) La incertidumbre sobre cua...

  20. PARTO PRETÉRMINO Y SUFRIMIENTO FETAL SECUNDARIOS A PERITONITIS POR APENDICITIS AGUDA PERFORADA

    OpenAIRE

    Hidalgo M,Juan José; Molina P,Marta; Varo GM,Begoña; Rivas R,Salvador; Bernabeu A,José Ramón; Perales M,Alfredo

    2009-01-01

    La apendicitis aguda es la urgencia quirúrgica no obstétrica más frecuente durante el embarazo. Se ha asociado a parto pretérmino y a morbimortalidad fetal y materna, especialmente cuando se complica con peritonitis. Los cambios anatómicos, fisiológicos y bioquímicos que se producen durante la gestación pueden alterar los síntomas y signos típicos asociados a la apendicitis. Esto puede retrasar el diagnóstico y dar lugar a un aumento de la morbimortalidad materna y fetal. Presentamos el caso ...

  1. Efecto de la restitución temprana de la nutrición oral en la pancreatitis aguda leve

    OpenAIRE

    Vega Sandoval, Carlos Andres; Isaza Restrepo, Andres; Moscoso Daza, Alejandro

    2010-01-01

    Aunque el manejo nutricional de los pacientes con Pancreatitis Aguda Severa ha sido bien establecido por la evidencia disponible, el inicio de la vía oral en Pancreatitis Leve no ha sido igualmente estudiado. El objetivo de este estudio es evaluar el efecto del inicio temprano de la nutrición por vía oral en estos pacientes. Métodos: Realizamos un descriptivo serie de comparación de casos en los cuales comparamos la evolución y resultados del manejo de los pacientes con pancreatitis aguda ant...

  2. Aspectos disautonômicos da porfiria aguda intermitente: a propósito de seis casos

    Directory of Open Access Journals (Sweden)

    Charles P. Tilbery

    1979-06-01

    Full Text Available Foram estudados seis casos de porfiria aguda intermitente, sendo enfocados os aspectos disautonômicos apresentados durante a longa permanência hospitalar dos doentes (média de 64 dias. Foram observados taquicardia sinusal e hipertensão arterial (4 casos, parada cardíaca (3 casos e depressão respiratória (5 casos. Os autores tecem comentários a propósito da fisiopatologia destas alterações e chamam a atenção sobre o prognóstico sombrio da porfiria aguda intermitente.

  3. Global emissions of the hydrofluorocarbons (HFCs) HFC-365mfc, HFC-245fa, HFC-227ea, and HFC-236fa based on atmospheric observations

    Science.gov (United States)

    Vollmer, M. K.; Miller, B. R.; Rigby, M. L.; Reimann, S.; Muhle, J.; Agage, Soge, Snu Members, Kopri Members

    2010-12-01

    We report on the atmospheric measurements and global emissions of the hydrofluorocarbons (HFCs) HFC-365mfc (CH3CH2CF2CF3, 1,1,1,3,3-pentafluorobutane), HFC-245fa (CHF2CH2CF3, 1,1,1,3,3-pentafluoropropane), HFC-227ea (CF3CHFCF3, 1,1,1,2,3,3,3-heptafluoropropane), and HFC-236fa (CF3CH2CF3, 1,1,1,3,3,3-hexafluoropropane). These measurements are from in-situ observations at stations of AGAGE (Advanced Global Atmospheric Gases Experiment) and SOGE (System for Observations of Halogenated Greenhouse Gases in Europe), and from the Korean station Gosan. We also report on flask sample measurements from the Antarctic stations King Sejong and Troll, and extend our records back to the 1970s using archived air samples of both hemispheres. All data are used in a global 12-box 2-dimensional atmospheric transport model to derive global abundances and emission estimates. All four HFCs have strongly increased in the atmosphere in recent years with growth rates at nearly 10 %, resulting in dry air mole fractions at the end of 2009 of 0.49 ppt for HFC-365mfc, 1.00 ppt for HFC-245fa, and 0.51 ppt for HFC-227ea. HFC-236fa, for which we report the first atmospheric measurements, is less abundant and has grown to 0.069 ppt at the end of 2009. Our model results show rapidly growing emissions of HFC-365mfc and HFC-245fa after 2002 but surprisingly these have now started to decline to globally 2.7 kt/yr (HFC-365mfc) and 6.1 kt/yr (HFC-245fa). On the other hand HFC-227ea and HFC-236fa show uninterrupted growth in their emissions of 2.5 kt/yr and 0.2 kt/yr at the end of 2009.

  4. FASE INTESTINAL DE Trichinella spiralis EN MODELO MURINO

    Directory of Open Access Journals (Sweden)

    MARÍA ALEJANDRA MORENO GARCÍA

    2009-01-01

    Full Text Available RESUMEN Trichinella spiralis se encuentra principalmente en el hombre, rata, cerdo, perro; puede infectar a cualquier carnívoro u omnívoro. Cuando la carne o sus derivados están contaminados con larvas infectantes (LI de T. spiralis y son ingeridas éstas pasan al estómago, donde sus cápsulas son disueltas por acción de los jugos gástricos, las larvas son liberadas en pocas horas, después pasan a la porción proximal del intestino delgado, donde se lleva a cabo su desarrollo. El objetivo del presente trabajo fue evaluar la fase intestinal de T. spiralis en un modelo murino. Un lote de 45 ratas Long Evans, se infectaron con aproximadamente 500 LI, y fueron sacrificadas tres diarias por 15 días. Se tomó un segmento de duodeno, yeyuno e íleon y se fijaron en formol al 10% para posteriormente ser procesados en parafina y teñido con hematoxilina-eosina. El resto del intestino delgado fue fraccionado, se incubó a 37 ºC por dos horas y el sobrenadante se observó al microscopio de luz. Se encontró que el implante se lleva a cabo a nivel de yeyuno e íleon, que las hembras adultas dan origen aproximadamente 60-80 larvas recién nacidas (LRN, parto vivíparo en un tercio distal y subse-cuentemente son destruidas. Los machos adultos tienen espermatozoides no ciliados. Palabras clave: larvas infectantes, adultos, larvas recién nacidas. ABSTRACT Trichinella spiralis is a parasitic disease in man, rat, pig, but can infect any carnivorous or omnivorous. When the meat or their derivates are contaminated with infective larvae (il of T. spiralis pass to the stomach, their capsules are dissolved by the stomach juice, the larvaes are liberated in few hours, and then they pass to the near portion of the slim intestine in which they develop. The objective of the present work was to evaluate the intestine phase of T. spiralis in a murine model. Fourtyfive Long Evans rats were infected with 500 li approximately, then 3 rats were sacrificed everyday

  5. Estrogen Inhibits Dlk1/FA1 Production: A Potential Mechanism for Estrogen Effects on Bone Turnover

    Science.gov (United States)

    Abdallah, B. M.; Bay-Jensen, A.; Srinivasan, B.; Tabassi, N. C.; Garnero, P.; Delaissé, J.; Khosla, S.; Kassem, M.

    2011-01-01

    We have recently identified Dlk1/FA1 (Delta-like 1/FA1) as a novel regulator of bone mass that functions to mediate bone loss, under estrogen deficiency, in mice. In this report, we investigated the effects of estrogen (E)-deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (s-CTx and s-osteocalcin), were measured in two cohorts: a group of pre- and postmenopausal women (n=100) and a group of postmenopausal women, where half had received estrogen replacement therapy (ERT) (n=166). s-Dlk1/FA1, and s-CTX were elevated in postmenopausal E-deficient compared to premenopausal E-replete women (both; P<0.001). s-Dlk1/FA1 was correlated with s-CTX (r=0.30, P<0.01). ERT, in postmenopausal women, decreased s-Dlk1/FA1, as well as s-CTX and s-osteoclacin (all; P<0.0001). Changes in s-Dlk1 were significantly correlated with those observed in s-CTx (r=0.18, P<0.05) and s-osteocalcin (r=0.28, P<0.001). In conclusion, s-Dlk1/FA1 is influenced by E-deficiency and is correlated with bone turnover. Increased levels of s-Dlk1/FA1 in post-menopausal women may be a mechanism mediating the effects estrogen deficiency on bone turnover. PMID:21681814

  6. Resposta circulatória à caminhada de 50 m na unidade coronariana, na síndrome coronariana aguda Respuesta circulatoria a la caminata de 50m en la unidad coronaria, en la síndrome coronaria aguda Circulatory response to a 50-m walk in the coronary care unit in acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Cristiane Maria Carvalho Costa Dias

    2009-02-01

    Full Text Available FUNDAMENTO: Ausência de técnica padronizada e monitorada para iniciar a reabilitação de pacientes com síndrome coronariana aguda (SCA, na unidade coronariana. OBJETIVO: Descrever a técnica e a resposta circulatória à caminhada de 50 m (C50m. MÉTODOS: Estudo experimental, transversal, com 65 pacientes com SCA; destes 36 (54% com infarto agudo do miocárdio (IAM, Killip I; 29 (45,2% com angina instável (AI; 61,5% do sexo masculino, idade 62,8 ± 12,7 anos. Caminhada com início 45 ± 23 horas pós-internamento. Mensuraram-se pressão arterial sistólica (PAS mmHg e diastólica (PAD mmHg, freqüência cardíaca (FC bpm, duplo produto (PAS mmHg X FC bpm, saturação periférica de oxigênio (SpO2%, tempo de caminhada e percepção do esforço pela escala de Borg (EB. Obtiveram-se medições nas posições supina, sentada e ortostase (fase 1 - estresse gravitacional, no final da caminhada e pós-repouso de 5 minutos (fase 2 - estresse físico. RESULTADOS: Observou-se aumento da FC ao estresse gravitacional sentado (Δ = 4,18 e em ortostase (Δ = 2,69, (p 142 mmHg ao sentar associou-se com aumento significativo (p = 0,031 de 11 mmHg ao exercício em 13 pacientes com sobrepeso/obesidade e 85% com hipertensão. Verificaram-se efeitos adversos em 19 (29,2% pacientes, tonturas em 23,1%, com impedimento da caminhada em três deles. CONCLUSÃO: Nesta amostra, após 24 horas do evento coronariano, não se verificaram efeitos colaterais graves à C50m.FUNDAMENTO: Ausencia de técnica estandarizada y de monitoreo para iniciarse la rehabilitación de pacientes con síndrome coronaria aguda (SCA, en la unidad coronaria. OBJETIVO: Describir la técnica y la respuesta circulatoria a la caminata de 50m (C50m./ MÉTODOS: Estudio experimental, transversal, con 65 pacientes con SCA; el número de 36 (54% de ellos con infarto agudo de miocardio (IAM, Killip I; un total de 29 (45,2% con angina instable (AI; el 61,5% del sexo masculino, edad 62,8 ± 12,7 a

  7. Desalination of Walls and Façades

    Science.gov (United States)

    Wedekind, W.; Jáuregui Arreola, K.; Siegesmund, S.

    2012-04-01

    For large monumental objects like walls and façades, the common technique of applying poultices for desalination often are not effective. This practice is neither cost effective nor does it lead to the desired result of desalination. To manage the conservation and desalination of these kinds of objects, several sprinkling techniques are known and have been applied on historical objects. For example, in the wooden warship Vasa, which was excavated from the sea bottom in Stockholm/Sweden, a sprinkling method was applied in 1961 for conservation and desalination. A sprinkling method to desalinate porous mineral materials will be presented using three different case studies: the rock cut monument no. 825 in Petra/Jordan, the medieval monastary church of the former Franziscan convent in Zeitz/Germany and the baroque monastary church Santa Monica in Guadalajara/Mexico. Before to start with practical conservation, the material- and petropysical properties, focoussed on water transport properties, like porosity, pore size distribution, water uptake and drying rate were investigadet. Diagnostic investigations on the objects included the mapping of deterioration, moister content measurements and salt accumulation determined by borehole cuts samples at depth. In the sprinkling method water is sprayed onto the wall surface through nozzels arranged in a modular grid. Depending on the sprinkling duration, a small or a large amount of water seeps into the porous materials, whereby the depth penetration can be adjusted accordingly. The water not absorbed by the stone runs off the facade and can be collected in liter amounts and tested by electrical conductivity with respect to the dissolved substances. After the drying of the wall's surface and the accumulation of salt at the material's surface, the procedure is repeated. For each subsequent washing a lower content of salt should be brought to the surface. Step by step the salt concentration will eventually decrease to almost

  8. Measurement of FA and VitB12 in serum by TRFIA and its clinical application

    International Nuclear Information System (INIS)

    Zhou Jinhong; Wang Huimin

    2006-01-01

    To investigate the correlation between diseases and the quantity of folic acid(FA) and vitamine B 12 (VitB 12 ) in serum, the quantity of FA and VitB 12 in serum was measured by TR- FIA. The results showed that the levels of FA and VitB 12 in 68 controlled subjects were 20.13±5.72 nmol/L and 240.45±58.23 pmol/L respectively. The levels of FA and VitB 12 in 6 patients with megaloblastic anemia, 26 with medium-terminal gestation femineity, 7 with liver cirrhosis, 10 with gastric ulcerand 31 with cerebral infarction were significant lower than those in the control group. The level of FA in 24 with malignant hematopathy and 57 with malignant tumor was significantly lower but VitB 12 between the 31 patients with iron deficiency anemia and 12 with CAA and the control group. The amount of the FA in 9 patients with chronic atrophic gastritis and 42 blood donors were lower than that in the control. The determination of FA and VitB 12 levels may be quite significant in the diagnosis, therapy and prognosis of diseases. Laboratories should establish the reference values which fit the locals specifically. (authors)

  9. Mielopatia transversa em adulto portador de leucemia aguda linfoblástica: relato de caso

    Directory of Open Access Journals (Sweden)

    Brito José Correia de Farias

    2001-01-01

    Full Text Available Relatamos um caso de mielopatia transversa aguda em paciente masculino de 31 anos de idade, branco, portador de leucemia aguda linfoblástica, subtipo L3 (LLA-L3. Esta é uma forma grave de leucemia e compromete mais crianças em relação aos adultos. Menos de 1% dos pacientes leucêmicos apresentam complicações espinais. No paciente em estudo, a sintomatologia instalou-se de modo abrupto e com as seguintes características: dores nas costas, paraplegia crural flácida e perda das funções sensitivas e vegetativas abaixo do segmento afetado. O diagnóstico etiológico foi estabelecido após a realização dos seguintes exames: hemograma, mielograma, análise do líquido cefalorraqueano e ressonância magnética de coluna dorsal. Foi instituído tratamento específico, que não interferiu com a evolução fatal da doença.

  10. Particularidades del síndrome de dificultad respiratoria aguda en edades pediátricas

    Directory of Open Access Journals (Sweden)

    Valentín Santiago Rodríguez Moya

    Full Text Available Desde las primeras descripciones del síndrome de dificultad respiratoria aguda los pediatras intensivistas reconocieron que posee particularidades que la hacen diferente en la población pediátrica. El objetivo de este trabajo es divulgar la definición específica en el modelo infantil, aunque existen similitudes en la fisiopatología del síndrome de dificultad respiratoria en adultos y niños. Se revisaron los conceptos vigentes sobre el síndrome de dificultad respiratoria aguda desde su descripción, a través de los diferentes consensos (desde el de 1994 hasta el de 2015 y se señalaron las recomendaciones en el tratamiento y seguimiento de esta entidad. Los tópicos que se trataron fueron: concepto; prevalencia y epidemiología; fisiopatología, severidad y enfermedades asociadas; soporte ventilatorio; tratamientos secundarios específicos sobre el pulmón; tratamientos concomitantes; monitoreo general y pulmonar; soporte ventilatorio no invasivo; terapia extracorpórea y el seguimiento a largo plazo. Las recomendaciones propuestas en la última conferencia de consenso para el tratamiento del síndrome de dificultad respiratoria en edades pediátricas permiten optimizar el tratamiento e identificar necesidades futuras de investigación del tema.

  11. Retinopatia de Purtscher-like e pancreatite aguda Purtscher-like retinopathy and acute pancreatitis

    Directory of Open Access Journals (Sweden)

    Kelly Fernandes de Paula Rodrigues

    2008-04-01

    Full Text Available Retinopatia de Purtscher-like é uma baixa súbita da visão associada à imagem de múltiplas áreas branco-amareladas (manchas algodonosas e hemorragias no pólo posterior de ambos os olhos. O exato mecanismo da injúria ainda não é claro, mas provavelmente seria de natureza embólica.Tem sido descrita em uma variedade de condições, incluindo pancreatite aguda, síndrome de embolia gordurosa, insuficiência renal, nascimento (parto e pós-parto, desordens do tecido conectivo, entre outras. Serão relatados três casos de pancreatite aguda confirmada pelos exames laboratoriais e história clínica, associadas a alterações no exame do fundo de olho, compatíveis com esta retinopatia.Purtscher-like retinopathy is acute loss of vision associated image of the multiple areas of retinal whitening and hemorrhage in the posterior pole of both eyes. The exact mechanism of injury remains unclear, current evidence suggests that it is embolic in nature. In a variety of conditions are been described including acute pancreatitis, fat embolism syndrome, renal failure, childbirth, and connective tissue disorders. Will are related three cases of the acute pancreatitis which was confirmed by complementary laboratory studies and clinical history, associated from exam of the fundus of the eye, similar is this retinopathy.

  12. Disrupting Façades of Clarity in the Teaching and Learning of Qualitative Research

    Directory of Open Access Journals (Sweden)

    Melissa Contreras-McGavin

    2013-02-01

    Full Text Available In this article we examine two methodological façades of clarity that commonly shroud critical qualitative educational inquiry. More specifically, we interrogate discussions of reflexivity and positionality and explore the ways in which methodology curricula and instructional practices perpetuate façades of clarity, or a false sense of coherence, ultimately undermining the transformative potential of critical educational research. We identify specific pedagogical opportunities, spaces, and strategies for dismantling these façades and offer ways to reconstruct methodological practices congruent with the emancipatory and empowering aims of critical scholarship.

  13. Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats

    OpenAIRE

    Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Bergseth, Marthe Tønder; Mjøs, Svein Are; Mola, Nazanin; Leh, Sabine Maria; Mellgren, Gunnar; Gudbrandsen, Oddrun Anita

    2017-01-01

    ABSTRACT Knowledge of the health impact of consuming heat-treated versus raw fish fillet is limited. To investigate effects of baked or raw salmon fillet intake on lipids and n-3 PUFAs in serum and tissues, obese Zucker fa/fa rats were fed diets containing 25% of protein from baked or raw salmon fillet and 75% of protein from casein, or casein as the sole protein source (control group) for four weeks. Salmon diets had similar composition of amino and fatty acids. Growth and energy intake were...

  14. Efectos sobre el metabolismo lipoproteico y estrés oxidativo en ratas zucker fa/fa de cárnicos enriquecidos con glucomanano y espirulina

    OpenAIRE

    González Torres, Laura

    2016-01-01

    Esta memoria doctoral versa sobre los estudios que se realizaron para evaluar los efectos de reestructurados cárnicos (RP) enriquecidos con glucomanano y espirulina sobre crecimiento, tamaño y estructura de órganos, glucemia, insulinemia, resistencia a la insulina, metabolismo lipoproteico y estrés oxidativo en un modelo de síndrome metabólico como es la rata Zucker fa/fa. Para ello se diseñaron diferentes dietas hipersaturadas, añadidas o no con agente hipercolesterolemiante, conteniendo 15%...

  15. Lesao óssea em leucemias agudas linfoblásticas tipo T e TIPO nao T / nao B

    OpenAIRE

    Martins, Fernando Lopes

    2013-01-01

    Resumo: O AUTOR APRESENTA OS RESULTADOS DO ESTUDO RADIOLÓGICO DE ESQUELETO DE 61 PACIENTES PORTADORES DE LEUCEMIA AGUDA LINFOBLÁSTICA, CORRELACIONANDO A PRESENÇA OU NÃO DE Lesões ÓSSEAS COM A CLASSIFICAÇÃO IMUNOLÓGICA DE LAL TIPO T E TIPO não T / não B

  16. Estudo da incidência de coledocolitíase em pacientes com colecistite calculosa aguda e crônica submetidos à colecistectomia vídeolaparoscópica

    Directory of Open Access Journals (Sweden)

    Sidney Moreno Gil

    Full Text Available OBJETIVO: Avaliar a incidência da coledocolitiase em pacientes submetidos à colecistectomia laparoscópica, portadores de colecistopatia calculosa aguda e crônica. O presente estudo, também, analisa se a era laparoscópica modificou a incidência e a história natural da litíase da via biliar quando compara os dados da literatura com os índices do Grupo estudado. MÉTODO: O estudo foi realizado em um Grupo de 946 pacientes, distribuídos em Grupo A de 214 pacientes de 1991-1995 e Grupo B de 732 pacientes de 1999-2007 colecistectomizados pelo método laparoscópico. O critério diagnóstico de coledocolitíase foi estabelecido por colangiofluoroscopia de rotina em todas as operações. RESULTADOS: A incidência total de coledocolitiase no Grupo A de 9,8% e no B de 5,8% não mostram diferença estatística significativa entre si e com a literatura mundial (p=0,08.Nos pacientes operados por colecistite aguda também não se observou diferença estatística entre o grupo A e B na incidência de litíase da via biliar( p=0,8. A análise dos dados nos pacientes operados por colecistite crônica revela uma taxa de coledocolitíase menor no Grupo B de 3,7% com significância estatística do que no A de 8,4% p=0,03. CONCLUSÃO: O presente estudo revela uma diminuição expressiva na incidência de coledocolitiase no Grupo B em relação ao A e a literatura mundial quando a indicação cirúrgica ocorre na fase não complicada da doença litiásica biliar. O estudo também demonstra um aumento significativo na indicação da colecistectomia laparoscópica eletiva mais precoce no Grupo B como já observado em diversas publicações da literatura médica.

  17. Estudio de separación de fases en sistemas líquido-líquido usando LIX 984N en fase orgánica

    Directory of Open Access Journals (Sweden)

    Castillo-Segura, J.

    2012-04-01

    Full Text Available In this work we studied the sedimentation and coalescence phenomena in liquid-liquid dispersion without chemical reaction, the aqueous electrolyte consisted of 0.25 M sodium sulfate and an organic phase characteristic organic extractant for copper (LIX 984N diluted in a commercial solvent (Shellsol 24 AR. The phenomena that dominate the phase separation have been studied by several researchers, which proposed a number of models to predict sedimentation and coalescence profiles. In this work we applied a semi-empirical model to describe the phenomena involved, varying the following experimental conditions: percentage of extractant in organic phase (5 - 30 % v / v, continuous phase (aqueous and organic, time and stirring speed (30 - 1800 s and 400 - 1200 rpm respectively. The main results show that from the 800 rpm of agitation this variable has no influence on primary breakup time, in the same way for 180 seconds of stirring produces the same effect. The fraction of dispersed phase in the packing zone found was 0.74. For higher levels of percentage of extractant in organic phase increased the phase separation time as when the organic phase was used as the continuous phase relative to the aqueous phase. We found a partial adjustment of the experimental data in relation to the simulated values , which is attributable to two factors: the initial inertia of the system once the agitation stopped and the existence of different times of inflection points of the curves of sedimentation and coalescence. In the different articles found in literature assume that the above phenomena occur simultaneously.

    En este trabajo se estudiaron los fenómenos de sedimentación y coalescencia en una dispersión líquido-líquido sin reacción química, la fase acuosa consistió en electrolito de sulfato de sodio 0,25 M y una fase orgánica de extractante característico para el cobre (LIX 984N diluido en un solvente comercial (shellsol 24 AR. Los fenómenos que

  18. Tratamento homeopático da hepatotoxicose aguda induzida por tetracloreto de carbono em coelhos Homeopatic treatment of acute carbon tetrachloride induced hepatotoxicity in rabbits

    Directory of Open Access Journals (Sweden)

    Maria Cecília Ribeiro Moncorvo

    1998-09-01

    Full Text Available Quinze (15 coelhos (Oryctolagus cuniculus foram submetidos à intoxicação pelo tetracloreto de carbono na dosagem de 0,5 ml/kg de peso corporal, dose única, administrado por sonda gástrica. Foram realizadas as dosagens de alanina amino transferase (ALT, aspartato amino transferase (AST, fosfatase alcalina (FA e gama glutamil transferase (GGT antes e durante o experimento. Vinte e quatro (24 horas após a intoxicação, os coelhos foram divididos aleatoriamente em três grupos de 5 animais. Cada grupo recebeu um tratamento diferente durante 13 dias. O grupo I foi tratado com tetracloreto de carbono diluído na 30ª centesimal hahnemanniana (30 CH, uma vez ao dia. O grupo II recebeu Phosphorus 30 CH, também uma vez ao dia. O grupo III desempenhou o papel de controle, recebendo diariamente uma dose de placebo, pelo mesmo período de tempo que os grupos anteriores. Os resultados das concentrações séricas de ALT, AST, GGT e FA foram submetidos à análise estatística. A variação da concentração de todas as enzimas foi significativa entre os dias, mas nem todas variaram significativamente entre os grupos considerados. O tetracloreto de carbono 30 CH foi capaz de acelerar a recuperação do quadro de hepatite tóxica aguda determinada pela redução dos níveis de ALT. O tratamento com Phosphorus 30 CH mostrou-se incapaz seja de reverter o quadro de hepatite tóxica, seja de acelerar a regeneração hepática.Fithteen (15 New Zeland and Californian rabbits (Oryctolagus cuniculus were submitted to intoxication with carbon tethracloride in a dose 0/0.5 ml/kg, once a day, administred by orogastric sonde. Enzimatic parameters: alanine aminotransferase (ALT, aspartate aminotransferase (AST, alkaline phosphatase and gamma-glutamyltransferase of those rabbits were tested before and during the experiment. After the intoxication, the rabbits were divided in three groups of five animals. Each group received differents treatments during 13 days. The

  19. Insuficiencia renal aguda en pacientes de la Unidad de Cuidados Intensivos, Hospital Regional de Cuilapa, Santa Rosa, Guatemala

    Directory of Open Access Journals (Sweden)

    Ronald J. Ajcalon

    2017-03-01

    Full Text Available La insuficiencia renal aguda, es una condición común en la Unidad de Cuidados Intensivos de Adultos (UCIA y probablemente una consecuencia de la enfermedad crítica que se asocia a resultados clínicos adversos, altos costos y una mortalidad de más del 50%, sobre todo si se requiere tratamiento de reemplazo renal. El objetivo fue determinar la incidencia de insuficiencia renal aguda en pacientes ingresados a la UCIA. El estudio fue prospectivo, longitudinal, observacional, en 101 pacientes ingresados en la UCIA del Hospital Regional de Cuilapa. Se diagnosticaron 101 pacientes durante el periodo de estudio con insuficiencia renal aguda represento el 27.4% del total de pacientes internados (368 en el servicio en un año. La incidencia de mortalidad en pacientes que requieren terapia de reemplazo renal y se encuentran en ventilación mecánica es del 100%. Del total de pacientes estudiados, según la escala Akin, se encontró que el 49.5% de los pacientes correspondían a grado II, aunque el grado I también fue frecuente (29%, y que el 22 % de los pacientes correspondían a grado III. La patología que mayormente se asoció al desarrollo de insuficiencia renal aguda fue sepsis grave con un 31%, seguido de pacientes sometidos a cirugía mayor e hipovolemia con el 21 y 18% respectivamente. Se halló una incidencia aumentada de insuficiencia renal aguda comparado con estadísticas internacionales, cuya etiología fue mayormente causada por procesos sépticos.

  20. O eletrocardiograma na fase crônica da doença de Chagas experimental no cão

    Directory of Open Access Journals (Sweden)

    J. Pellegrino

    1946-03-01

    Full Text Available O Autor estudou o eletrocardiograma de 6 cães adultos antes e após a inoculação, nestes animais, de uma amostra de Schizotrypanum cruzi obtida de um caso humano de miocardite chagásica com bloqueio aurículo-ventricular total. A fase aguda da moléstia nos cães foi seguida por frequentes exames de sangue a fresco, entre lãmina e lamínula, para a pesquisa do flagelado. Os traçados eletrocardiográficos foram obtidos antes da inoculação e até 320 dias após a mesma. Além das derivações periféricas, em alguns cães, registrou também as derivações precordiais. A interpretação dos eletrocardiogramas seriados foi feita levando-se em conta a variabilidade dos traçados em série observada em cães normais. Em todos os 6 cães estudados houve uma diminuição muito acentuada da voltagem dos complexos ventriculares, denotando lesão miocárdica. A diminuição da voltagem de QRs já se evidencia na fase aguda e de transição da moléstia, tornando-se máxima logo no inicio da fase crônica. Em dois cães, paralelamente com a diminuição da voltagem, houve uma rotação do eixo elétrico para a esquerda. Em um cão foram observadas extrasístoles ventriculares e, em dois, extrasístoles auriculares. Somente em um cão observou alterações significativas da onda P. constituidas por alargamento e entalhe da mesma. O Autor salienta e discute o fato de não ter encontrado alterações na condução (não houve aumento de Pr e somente em um caso houve alargamento significativo de QRS. As pesquizas ainda continuam sendo apenas parciais os resultados apresentados. Agradecemos ao Prof. AMERICANO FREIRE pelas sugestões e ao Sr. KURT BENSEMANN pela constante assistencia técnica.The Author has studied the electrocardiograms of 6 adult dogs, before and after the inoculation of a Schizotrypanum cruzi strain in these animals, which has been obtained from a human case of Chagas' myocarditis with complete aurriculoventricular block. The acute

  1. Data of evolutionary structure change: 1A4FA-2ZLWD [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1A4FA-2ZLWD 1A4F 2ZLW A D -VLSAADKTNVKGVFSKISGHAEEYGAETLERMFTAYPQ...R VQLSGEEKAAVLALWDKV--NEEEVGGEALGRLLVVYPWTQRFFDSFGDLSNPGAVMGNPKVKAHGKKVLHSFGEGVHHLDNLKGTFAALSEL... 2ZLW D 2ZLWD LWDKV--

  2. Foetal antigen 2 (FA2) in the stromal reaction induced by breast carcinoma

    DEFF Research Database (Denmark)

    Rasmussen, H B; Teisner, B; Andersen, J A

    1992-01-01

    An indirect immunoperoxidase technique was used to examine the distribution of foetal antigen 2 (FA2), a recently described basement membrane (BM)-associated antigen, in invasive breast carcinoma (n = 34), fibroadenoma (n = 5) and normal breast tissue (n = 5), and to compare its distribution...... with that of laminin and collagen type IV. In normal breast tissue, FA2 was detected in the intralobular stroma as a broad band around acini and ducts, but was not present in the interlobular stroma. In areas of carcinoma in situ, FA2 was present diffusely around and in close contact with the glandular elements......, the staining being more intense than that found around normal glandular structures. Two distinct patterns of FA2 distribution were found in adenocarcinomas of the breast. In the fibroblast reaction type, fibroblast staining dominated, whilst in the stromal reaction type, intense and extensive staining...

  3. Data of evolutionary structure change: 1J3FA-1LHSA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1J3FA-1LHSA 1J3F 1LHS A A MVLSEGEWQLVLHVWAKVEADVAGHGQDILIRLFKSHPE...TLEKFDRFKHLKTEAEMKASEDLKKHGVTVLTGLGAILKKKGHHEAELKPLAQSHAT--KIPIKYLEFISEAIIHVLHSRHPGDFGADAQGAMNKALELFRKDIAAKY...line>ILE CA 332 LYS CA 290 1LHS A 1LHSA ESHATKHKIPVK HH

  4. Pengoperasian Beban Listrik Fase Tunggal Terkendali Melalui Minimum System Berbasis Mikrokontroler Dan Sensor Voice Recognition (Vr)

    OpenAIRE

    Goeritno, Arief; Ginting, Sandy Ferdiansyah; Yatim, Rakhmad

    2017-01-01

    Minimum system berbasis mikrokontroler dan sensor voice recognition (VR) sebagai pengendali aktuator telah digunakan untuk pengoperasian beban listrik fase tunggal. Minimum system adalah suatu sistem yang tersusun melalui 2 (dua) tahapan, yaitu (a) diagram rangkaian dan bentuk fisis board dan (b) pengawatan terintegrasi terhadap minimum system pada sistem mikrokontroler ATmega16. Keberadaan sistem mikrokontroler pada minimum system perlu program tertanam melalui pemrograman berbasis bahasa ...

  5. ECO-driving met behulp van serious gaming en social media (fase 1)

    NARCIS (Netherlands)

    Kuiper, H.; Boonekamp, R.C.; Bijlsma, T.; Jansen, S.T.H.; Obdeijn, C.; Stuiver, A.; Spronkmans, S.; Bijnen, D.; Versteegh, T.

    2013-01-01

    Dit rapport beschrijft fase 1 van een EL&I cofinancieringstraject waarin onderzoek wordt gedaan naar gedragsbeïnvloeding bij automobilisten om CO2-reductie te bereiken met behulp van Serious gaming en Social Media. Het onderzoek sluit goed aan bij het overheidswerkprogramma “Schoon en Zuinig”

  6. ANSIEDAD–ESTADO A LO LARGO DE LAS FASES DE COMPETENCIA DEPORTIVA

    Directory of Open Access Journals (Sweden)

    Jaime Alberto Arenas Granada

    2014-11-01

    Full Text Available Con el objetivo de conocer el comportamiento de la ansiedad–estado en tres fases de competencia deportiva (clasificatoria, semifinal y final e identificar diferencias entre el género, delegaciones y experiencia deportiva, fue empleada la escala de ansiedad–estado del Inventario de Ansiedad Estado y Rasgo (IDARE/STAI, para lo cual se obtuvo un total de 173 datos (clasificatoria, n= 98; semifinal, n=43; final n= 32 en una muestra intencional de hombres y mujeres voleibolistas representantes de seis instituciones universitarias. Estudio empírico cuantitativo, de alcance longitudinal y análisis estadístico no paramétrico. Los resultados permitieron establecer la correlación positiva y significativa entre las fases de competencia y los niveles de ansiedad–estado, se observaron diferencias significativas en el género, en función al promedio general y la fase clasificatoria; con mayores puntajes de ansiedad–estado por parte de las mujeres. Los promedios de las fases no establecieron diferencias estadísticamente significativas, como tampoco se observó en las delegaciones, ni en la experiencia deportiva. Sin embargo, se destaca la importancia de la experiencia deportiva como variable a considerar en las demandas de la competencia deportiva. Los resultados son discutidos y direccionados a la instauración de programas de entrenamiento psicológico, así como el desarrollo de nuevos trabajos en esta línea.

  7. The effect of architectural façade design on energy savings in the student dormitory

    OpenAIRE

    Pejić Petar Č.; Petković Dušan Lj.; Krasić Sonja M.

    2014-01-01

    There are many reasons for adequate use of natural light inside students' dormitories. Intensity of light required for student activities and temperature inside the rooms are the major factors for an occupant's comfortable work and life. Design of building façades has a significant impact both on the use of natural light and energy consumption. In this paper, a comparative analysis of student rooms with different orientations and different façade designs wa...

  8. A Conserved Metal Binding Motif in the Bacillus subtilis Competence Protein ComFA Enhances Transformation.

    Science.gov (United States)

    Chilton, Scott S; Falbel, Tanya G; Hromada, Susan; Burton, Briana M

    2017-08-01

    Genetic competence is a process in which cells are able to take up DNA from their environment, resulting in horizontal gene transfer, a major mechanism for generating diversity in bacteria. Many bacteria carry homologs of the central DNA uptake machinery that has been well characterized in Bacillus subtilis It has been postulated that the B. subtilis competence helicase ComFA belongs to the DEAD box family of helicases/translocases. Here, we made a series of mutants to analyze conserved amino acid motifs in several regions of B. subtilis ComFA. First, we confirmed that ComFA activity requires amino acid residues conserved among the DEAD box helicases, and second, we show that a zinc finger-like motif consisting of four cysteines is required for efficient transformation. Each cysteine in the motif is important, and mutation of at least two of the cysteines dramatically reduces transformation efficiency. Further, combining multiple cysteine mutations with the helicase mutations shows an additive phenotype. Our results suggest that the helicase and metal binding functions are two distinct activities important for ComFA function during transformation. IMPORTANCE ComFA is a highly conserved protein that has a role in DNA uptake during natural competence, a mechanism for horizontal gene transfer observed in many bacteria. Investigation of the details of the DNA uptake mechanism is important for understanding the ways in which bacteria gain new traits from their environment, such as drug resistance. To dissect the role of ComFA in the DNA uptake machinery, we introduced point mutations into several motifs in the protein sequence. We demonstrate that several amino acid motifs conserved among ComFA proteins are important for efficient transformation. This report is the first to demonstrate the functional requirement of an amino-terminal cysteine motif in ComFA. Copyright © 2017 American Society for Microbiology.

  9. Molecular causes and consequences of genetic instability with respect to the FA/BRCA Caretaker Pathway

    OpenAIRE

    Neveling, Kornelia

    2012-01-01

    In the context of this thesis, I investigated the molecular causes and functional consequences of genetic instability using a human inherited disease, Fanconi anemia. FA patients display a highly variable clinical phenotype, including congenital abnormalities, progressive bone marrow failure and a high cancer risk. The FA cellular phenotype is characterized by spontaneous and inducible chromosomal instability, and a typical S/G2 phase arrest after exposure to DNA-damaging agents. So far, 13 g...

  10. Status of JSFR development in phase I FaCT project

    International Nuclear Information System (INIS)

    Aoto, Kazumi; Chikazawa, Yoshitaka; Kotake, Shoji; Ito, Takaya

    2011-01-01

    The Fast Reactor Cycle Technology Development (FaCT) project is pursuing commercialization of fast reactor cycle system around 2050 under cooperation of MEXT (Ministry of Education, Culture, Sports, Science and Technology), METI (Ministry of Economy, Trade and Industry), utilities, venders and JAEA (Japan Atomic Energy Agency). As results of the FaCT Phase I, the key technologies for Japan Sodium-cooled Fast Reactor (JSFR) has been evaluated. (author)

  11. Diets containing salmon fillet delay development of high blood pressure and hyperfusion damage in kidneys in obese Zucker fa/fa rats.

    Science.gov (United States)

    Vikøren, Linn A; Drotningsvik, Aslaug; Mwakimonga, Angela; Leh, Sabine; Mellgren, Gunnar; Gudbrandsen, Oddrun A

    2018-04-01

    Hypertension is the leading risk factor for cardiovascular and chronic renal diseases, affecting more than 1 billion people. Fish intake is inversely correlated with the prevalence of hypertension in several, but not all, studies, and intake of fish oil and fish proteins has shown promising potential to delay development of high blood pressure in rats. The effects of baked and raw salmon fillet intake on blood pressure and renal function were investigated in obese Zucker fa/fa rats, which spontaneously develop hypertension with proteinuria and renal failure. Rats were fed diets containing baked or raw salmon fillet in an amount corresponding to 25% of total protein from salmon and 75% of protein from casein, or casein as the sole protein source (control group) for 4 weeks. Results show lower blood pressure and lower urine concentrations of albumin and cystatin C (relative to creatinine) in salmon diet groups when compared to control group. Morphological examinations revealed less prominent hyperfusion damage in podocytes from rats fed diets containing baked or raw salmon when compared to control rats. In conclusion, diets containing baked or raw salmon fillet delayed the development of hypertension and protected against podocyte damage in obese Zucker fa/fa rats. Copyright © 2018 American Heart Association. Published by Elsevier Inc. All rights reserved.

  12. Primeras experiencias con drenaje biliar percutáneo de urgencia en la colangitis aguda

    Directory of Open Access Journals (Sweden)

    José Luis González González

    Full Text Available Introducción: la obstrucción biliar es motivo frecuente de morbilidad en los pacientes con metástasis hepáticas, adenopatías periportales y cáncer hepatobiliopancreático. La colangitis aguda es la complicación más temida, debido a su mortalidad. En este trabajo se presentan los primeros abordajes percutáneos realizados por cirujanos del Hospital Clínicoquirúrgico "Hermanos Ameijeiras" como herramienta para el tratamiento urgente de esta entidad. Objetivo: caracterizar el drenaje percutáneo transparietohepático de urgencia en pacientes con colangitis aguda e ictericia obstructiva. Métodos: se realizó un estudio descriptivo, prospectivo y aplicado con 30 pacientes atendidos de esta forma en dicha institución entre enero de 2008 y diciembre de 2010. Resultados: el diagnóstico etiológico preponderante fue el de tumor maligno de la cabeza del páncreas. La localización baja de la lesión duplicó a la localización alta. La mejoría clínica de la ictericia se evidenció en la mayoría de los pacientes después de una semana tras el procedimiento: el drenaje percutáneo constituyó el método definitivo en el 73,3 % de los pacientes. Las edades medias para los distintos diagnósticos etiológicos exhibieron diferencias estadísticamente significativas. No hubo complicaciones ni mortalidad relacionadas con el procedimiento. Conclusiones: el drenaje biliar percutáneo guiado por ultrasonido es una herramienta útil y segura para el tratamiento de urgencia de la colangitis aguda. Es un método que pueden realizar los cirujanos generales con entrenamiento adecuado y específico, y tiene asociadas pocas complicaciones.

  13. Caracterización inmunofenotípica de pacientes con leucemia mieloide aguda

    Directory of Open Access Journals (Sweden)

    Daily Pino Blanco

    Full Text Available Introducción: la leucemia mieloide aguda incluye un grupo heterogéneo de neoplasias caracterizadas por una expansión clonal de mieloblastos, cuya clasificación involucra varios criterios, incluidos los inmunológicos. Objetivo: caracterizar el inmunofenotipo de los pacientes con leucemia mieloide aguda evaluados en el Instituto de Hematología e Inmunología. Métodos: se realizó un estudio descriptivo transversal de los pacientes diagnosticados con este tipo de leucemia, cuyas muestras de sangre fueron procesadas en el Departamento de Inmunología en el período 2008-2012. Se usó un ultramicrométodo inmunocitoquímico que utiliza un panel de anticuerpos monoclonales específicos de antígenos mieloides y linfoides. Las variables analizadas fueron: edad, sexo, subtipo de leucemia y expresión de marcadores inmunológicos, cuyas asociaciones fueron analizadas con los estadígrafos Chi-cuadrado y coeficiente de correlación de Spearman. Resultados: se estudiaron 58 pacientes, 28 del sexo femenino y 30 del masculino. El grupo de edad predominante fue de 0 a 9 años con una mediana de 26 años. El subtipo M4 resultó el más frecuente (30,4 %. Los subtipos M4 y M7 predominaron en niños, mientras que el M0, predominó en adultos, con diferencias estadísticamente significativas (p d»0,05. La combinación de los antígenos panmieloides CD13 y CD33 se presentó en el 91 % de los enfermos. Las combinaciones de CD13/CD33, CD14/CD15, CD33/CD14 y CD33/CD15 mostraron correlación significativa. En el 20,6 % de los pacientes evaluados, fueron detectados, además, antígenos linfoides. No se encontraron diferencias significativas en cuanto al sexo y la edad. El antígeno CD7 fue el más expresado, seguido de los antígenos: CD3, CD20, CD22 y CD79, en igual proporción. Conclusiones: el inmunofenotipaje celular demostró ser un procedimiento útil para confirmar el diagnóstico morfológico y clínico de la leucemia mieloide aguda.

  14. Leucemia linfoblástica aguda em lactentes: 20 anos de experiência

    Directory of Open Access Journals (Sweden)

    Amanda Ibagy

    2013-02-01

    Full Text Available OBJETIVO: Analisar pacientes com menos de dois anos de idade com leucemia linfoblástica aguda atendidos no período de 1990 a 2010, em um centro de referência estadual. MÉTODOS: Estudo clínico, epidemiológico, transversal, descritivo e observacional. Pacientes incluídos tinham menos de dois anos de idade, com leucemia linfoblástica aguda, tratados no período de 1990 a 2010 na unidade de oncologia pediátrica de um centro de referência estadual, totalizando 41 casos. RESULTADOS: Todos os pacientes eram Caucasianos e 60,9% eram do sexo feminino. Com relação à idade, 24,38% tinham menos de seis meses, 17,07% tinham entre seis meses e um ano e 58,53% mais do que um ano de idade. A idade de seis meses foi estatisticamente significante para o desfecho de óbito. Os sinais e sintomas predominantes foram febre, hematomas e petéquias. Uma contagem de leucócitos superior a 100.000 foi observada em 34,14% dos casos; hemoglobina inferior a 11 em 95,13% e contagem de plaquetas inferior a 100.000, em 75,61% dos casos. Infiltração do sistema nervoso central estava presente em 12,91% dos pacientes. Em relação à linhagem, a linhagem B predominou (73%, mas a linhagem de células T foi estatisticamente significativa para o óbito. Trinta e nove por cento dos pacientes tiveram recorrência da doença. Em relação ao estado vital, 70,73% dos pacientes morreram, sendo choque séptico a principal causa. CONCLUSÕES: leucemia linfoblástica aguda em crianças tem uma alta taxa de mortalidade, principalmente em crianças menores de um ano e linhagem derivada de células T.

  15. Suscetibilidade genética na lesão pulmonar aguda e síndrome da angústia respiratória aguda Genetic susceptibility in acute lung injury and acute respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Fernando Suparregui Dias

    2009-12-01

    Full Text Available A lesão pulmonar aguda e sua forma mais grave, a síndrome da angústia respiratória aguda, são o denominador comum de várias doenças que podem provocar uma inflamação exagerada nos pulmões. Nos últimos anos, essa variabilidade tem sido atribuída, pelo menos em parte, a fatores genéticos. O presente estudo tem por objetivos revisar o papel dos principais genes envolvidos na suscetibilidade, morbidade e mortalidade na lesão pulmonar aguda e na síndrome da angústia respiratória aguda. Através de pesquisa nas bases de dados PubMed e LiLACS, empregando-se os unitermos lesão pulmonar aguda, síndrome da angústia respiratória aguda e síndrome da angústia respiratória do adulto em combinação com polimorfismos genéticos, foram selecionados 69 artigos, dos quais 38 foram incluídos nesta revisão. Foram também considerados artigos relevantes extraídos das referências bibliográficas nos artigos selecionados das bases de dados. Os polimorfismos genéticos são variantes gênicas presentes em pelo menos 1% da população. A presença destas variantes genéticas pode influenciar a expressão de mediadores da resposta inflamatória, afetando diretamente a suscetibilidade à lesão pulmonar aguda, a intensidade da inflamação no parênquima pulmonar, a evolução e o desfecho destes pacientes. Estudos de associação com grandes populações e passíveis de reprodução permitirão de modo definitivo a inclusão da genômica no arsenal diagnóstico, prognóstico e terapêutico de pacientes com lesão pulmonar aguda/síndrome da angústia respiratória agudaAcute lung injury and its most severe presentation, acute respiratory distress syndrome, are a common denominator for several diseases which can lead to exaggerated lung inflammation. In the last years this variability has been ascribed, at least partially, to genetic issues. This study aims to review the role of the main genes involved in acute lung injury and acute respiratory

  16. The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco.

    Science.gov (United States)

    Aharoni, A; De Vos, C H; Wein, M; Sun, Z; Greco, R; Kroon, A; Mol, J N; O'Connell, A P

    2001-11-01

    Fruit ripening is characterized by dramatic changes in gene expression, enzymatic activities and metabolism. Although the process of ripening has been studied extensively, we still lack valuable information on how the numerous metabolic pathways are regulated and co-ordinated. In this paper we describe the characterization of FaMYB1, a ripening regulated strawberry gene member of the MYB family of transcription factors. Flowers of transgenic tobacco lines overexpressing FaMYB1 showed a severe reduction in pigmentation. A reduction in the level of cyanidin 3-rutinoside (an anthocyanin) and of quercetin-glycosides (flavonols) was observed. Expression of late flavonoid biosynthesis genes and their enzyme activities were adversely affected by FaMYB1 overexpression. Two-hybrid assays in yeast showed that FaMYB1 could interact with other known anthocyanin regulators, but it does not act as a transcriptional activator. Interestingly, the C-terminus of FaMYB1 contains the motif pdLNL(D)/(E)Lxi(G)/S. This motif is contained in a region recently proposed to be involved in the repression of transcription by AtMYB4, an Arabidopsis MYB protein. Our results suggest that FaMYB1 may play a key role in regulating the biosynthesis of anthocyanins and flavonols in strawberry. It may act to repress transcription in order to balance the levels of anthocyanin pigments produced at the latter stages of strawberry fruit maturation, and/or to regulate metabolite levels in various branches of the flavonoid biosynthetic pathway.

  17. Fetal antigen 1 (FA1), a circulating member of the epidermal growth factor (EGF) superfamily

    DEFF Research Database (Denmark)

    Jensen, Charlotte Harken; Krogh, T N; Støving, René Klinkby

    1997-01-01

    We describe an ELISA technique for quantification of fetal antigen 1 (FA1), a glycoprotein belonging to the EGF-superfamily. The ELISA is based on immunospecifically purified polyclonal antibodies and has a dynamic range of 0.7-5.3 ng/ml, intra- and inter-assay C.V.s of less than 3.2% and an aver......We describe an ELISA technique for quantification of fetal antigen 1 (FA1), a glycoprotein belonging to the EGF-superfamily. The ELISA is based on immunospecifically purified polyclonal antibodies and has a dynamic range of 0.7-5.3 ng/ml, intra- and inter-assay C.V.s of less than 3.......2% and an average recovery of 105% in serum and 98% in urine. Comparison of FA1 in amniotic fluid, serum and urine revealed parallel titration curves, identical elution volumes following size chromatography, immunological identity and similar profiles when analysed by MALDI-MS. The reference interval for serum FA1...... was 12.3-46.6 ng/ml and the levels were 10 times higher in patients with renal failure. FA1 showed no diurnal variation, no variation during the menstrual cycle and was not influenced by the acute phase reaction. In humans (n = 10) the renal clearance of FA1 was 11 ml/min and an identical high renal...

  18. A BPMN-based process map for the design and construction of façades

    Directory of Open Access Journals (Sweden)

    Eleanor Voss

    2013-12-01

    Full Text Available Corresponding author: Eleanor Voss, Glass and Façade Technology Research Group, Department of Engineering, University of Cambridge, Trumpington Street, Cambridge, UK. E-mail: ev236@cam.ac.uk Process mapping can lead to significant efficiency and quality improvements in construction engineering and is an ideal basis for developing IT support tools. The increasing complexity and multidisciplinary nature of façade design and construction suggest that a process map would be beneficial in this sector of the construction industry, but it has received limited attention to date. This paper presents a verified process map of the façade design and construction process. The map is the first of its kind to represent, in detail, the whole process relevant to all façade types, from commencement of the façade consultant's and contactor's participation, to the end of their involvement. The paper describes the process by which the mapping notation was selected, followed by the development and verification of the process map, including testing in two independent research projects. The BuildingSMART's BPMN notation is found to have superior system features and comprehensibility for this application and the resulting process map is easy to interpret and verify by industry experts. The trialling of the map in the two research projects indicate that the map is a useful tool for assessing process improvements in the façades sector.

  19. Architectural Kansei of ‘Wall’ in The Façade Design by Le Corbusier

    Science.gov (United States)

    Sendai, Shoichiro

    The purpose of this paper is to discuss the modern architect Le Corbusier's architectural Kansei (sensibility) on wall in site environment through the analysis of his façade design, using Œuvres complètes (1910-1965, 8 vols., Les éditions d'architecture, Artemis, Zurich) and Le Corbusier Archives (1982-1984, 32 vols., Garland Publishing, Inc. and Fondation Le Corbusier, New York, London, Paris). At first, I arrange five façade types, according to the explanation by Le Corbusier ; ‘fenêtre en longueur (strip window)’, ‘pan de verre (glass wall)’, ‘brise-soleil (sun-breaker)’, ‘loggia’ and ‘claustra’. Through the analysis of the relationship between these types and the design process of each building, we find that Le Corbusier's façade design includes the affirmation and the negation of the ‘wall’ at the same time. In fact, the nature of façade modification during design process is divers: increase in transparency, decrease in transparency and spatialization of façade. That means, Le Corbusier studied the environmental condition by these façade types, and tried to realize the phenomenal openness. This trial bases on the function of architectural Kansei as correspondence between body and environment beyond the physical design.

  20. Energy performance of a ventilated façade by simulation with experimental validation

    International Nuclear Information System (INIS)

    Aparicio-Fernández, Carolina; Vivancos, José-Luis; Ferrer-Gisbert, Pablo; Royo-Pastor, Rafael

    2014-01-01

    A model for a building with ventilated façade was created using the software tool TRNSYS, version 17, and airflow parameters were simulated using TRNFlow. The results obtained with the model are compared and validated with experimental data. The temperature distribution along the air cavity was analysed and a chimney effect was observed, which produced the highest temperature gradient on the first floor. The heat flux of the external wall was analysed, and greater temperatures were observed on the external layer and inside the cavity. The model allows to calculate the energy demand of the building façade proposing and evaluating passive strategies. The corresponding office building for computer laboratories located in Valencia (Spain), was monitored for a year. The thermal behaviour of the floating external sheet was analysed using an electronic panel designed for the reading and storage of data. A feasibility study of the recovery of hot air inside the façade into the building was performed. The results obtained showed a lower heating demand when hot air is introduced inside the building, increasing the efficiency of heat recovery equipment. - Highlights: •An existing office building was monitored for a year. •A model of a ventilated façade by TRNSYS simulation tool was validated. •Air flow parameters inside the ventilated façade were identified. •Recovery of the hot air inside the façade for input into the building was studied

  1. Atmospheric histories and global emissions of the anthropogenic hydrofluorocarbons HFC-365mfc, HFC-245fa, HFC-227ea, and HFC-236fa

    Science.gov (United States)

    Vollmer, Martin K.; Miller, Benjamin R.; Rigby, Matthew; Reimann, Stefan; Mühle, Jens; Krummel, Paul B.; O'Doherty, Simon; Kim, Jooil; Rhee, Tae Siek; Weiss, Ray F.; Fraser, Paul J.; Simmonds, Peter G.; Salameh, Peter K.; Harth, Christina M.; Wang, Ray H. J.; Steele, L. Paul; Young, Dickon; Lunder, Chris R.; Hermansen, Ove; Ivy, Diane; Arnold, Tim; Schmidbauer, Norbert; Kim, Kyung-Ryul; Greally, Brian R.; Hill, Matthias; Leist, Michael; Wenger, Angelina; Prinn, Ronald G.

    2011-04-01

    We report on ground-based atmospheric measurements and emission estimates of the four anthropogenic hydrofluorocarbons (HFCs) HFC-365mfc (CH3CF2CH2CF3, 1,1,1,3,3-pentafluorobutane), HFC-245fa (CHF2CH2CF3, 1,1,1,3,3-pentafluoropropane), HFC-227ea (CF3CHFCF3, 1,1,1,2,3,3,3-heptafluoropropane), and HFC-236fa (CF3CH2CF3, 1,1,1,3,3,3-hexafluoropropane). In situ measurements are from the global monitoring sites of the Advanced Global Atmospheric Gases Experiment (AGAGE), the System for Observations of Halogenated Greenhouse Gases in Europe (SOGE), and Gosan (South Korea). We include the first halocarbon flask sample measurements from the Antarctic research stations King Sejong and Troll. We also present measurements of archived air samples from both hemispheres back to the 1970s. We use a two-dimensional atmospheric transport model to simulate global atmospheric abundances and to estimate global emissions. HFC-365mfc and HFC-245fa first appeared in the atmosphere only ˜1 decade ago; they have grown rapidly to globally averaged dry air mole fractions of 0.53 ppt (in parts per trillion, 10-12) and 1.1 ppt, respectively, by the end of 2010. In contrast, HFC-227ea first appeared in the global atmosphere in the 1980s and has since grown to ˜0.58 ppt. We report the first measurements of HFC-236fa in the atmosphere. This long-lived compound was present in the atmosphere at only 0.074 ppt in 2010. All four substances exhibit yearly growth rates of >8% yr-1 at the end of 2010. We find rapidly increasing emissions for the foam-blowing compounds HFC-365mfc and HFC-245fa starting in ˜2002. After peaking in 2006 (HFC-365mfc: 3.2 kt yr-1, HFC-245fa: 6.5 kt yr-1), emissions began to decline. Our results for these two compounds suggest that recent estimates from long-term projections (to the late 21st century) have strongly overestimated emissions for the early years of the projections (˜2005-2010). Global HFC-227ea and HFC-236fa emissions have grown to average values of 2.4 kt yr-1

  2. Oxide fuel fabrication technology development of the FaCT project (1). Overall review of fuel technology development of the FaCT project

    International Nuclear Information System (INIS)

    Abe, Tomoyuki; Namekawa, Takashi; Tanaka, Kenya

    2011-01-01

    The FaCT project is in progress in Japan for the commercialization of fast reactor cycle system. The development goal of the fuel in the FaCT project is a low-decontaminated TRU homo-recycling in a closed cycle and extension in average discharge burn-up to 150 GWd/t. Research and development on innovative technologies concerning the short process, remote maintenance and cooling system of automatic fuel production equipments, long life cladding material and control of oxygen potential have been conducted in phase I of the FaCT project. As the result of various test including 600 g batch MOX tests, it is concluded that the short process is available to fuel pellet fabrication of the FaCT project. Although cold mock-up tests on test model of some typical process equipments suggest possibilities of remote maintenance of automatic fuel fabrication equipment, it is concluded that it still needs further efforts to judge the operability of the completely remote fabrication for low-decontaminated TRU fuel. A cold mock-up test on fuel pin assembling equipment show that influence of decay heat of MA can be managed by cooling system. Irradiation tests in BOR-60 indicate that 9Cr-ODS possess the satisfactory in-reactor performance as the long life cladding material if homogeneity of alloy element is adequately controlled. Modification of cladding tube fabrication process to ensure homogeneity and further development of measures to control oxygen potential inside the fuel pin are necessary to reach the burn-up target of the FaCT project. (author)

  3. Hemiplejía aguda infantil asociada a infección por enterovirus

    OpenAIRE

    Muñoz, Erika; Caramuta, Luciana; Frenkel, Susana; Cáceres, Lidia

    2005-01-01

    El ictus isquémico en la infancia es una entidad infrecuente, en el 50% de los casos no existe una causa identificable. Sin embargo, con el advenimiento de nuevas técnicas diagnósticas se han podido conocer más afecciones causales. Presentamos el caso de una paciente de 9 años con hemiplejía aguda izquierda, con estudios de neuroimágenes poco significativos y en la cual el análisis del líquido cefalorraquídeo por método de reacción en cadena de polimerasa (PCR) para ARN viral, fue positivo pa...

  4. Diagnósticos de enfermagem em adultos com leucemia mielóide aguda

    OpenAIRE

    Souza, Luccas Melo de; Gorini, Maria Isabel Pinto Coelho

    2006-01-01

    Trata-se de um estudo de casos, que objetivou identificar os Diagnósticos de Enfermagem (DE) de pacientes adultos com Leucemia Mielóide Aguda, a fim de fornecer subsídios à Sistematização da Assistência de Enfermagem. Utilizaram-se as técnicas de entrevista e observação, além da aplicação do Processo de Enfermagem. Durantes os três meses da coleta de dados, outros DEs foram encontrados através de novas buscas nos prontuários dos 6 pacientes. Os 32 DEs encontrados foram agrupados conforme a Te...

  5. Toxicidade aguda do extrato aquoso de folhas de Erythrina velutina em animais experimentais

    Directory of Open Access Journals (Sweden)

    Ariadne Conceição Santos Craveiro

    Full Text Available Este trabalho teve como objetivo a avaliação da toxicidade aguda do extrato aquoso de folhas de Erythrina velutina, espécie vegetal muito usada na medicina popular principalmente como tranqüilizante. O protocolo experimental utilizado seguiu o Guia para a Realização de Estudos de Toxicidade Pré-clínica de Fitoterápicos da Agência Nacional de Vigilância Sanitária (Anvisa, 2004. Ratos Wistar adultos foram tratados por via oral com a dose limite de 5 g/kg do extrato e observados por 14 dias consecutivos. Nenhum animal veio a óbito e nenhum sinal de toxicidade foi detectado nas observações comportamentais ou nas autópsias, indicando uma razoável atoxicidade do extrato.

  6. Ataxia cerebelar aguda na criança Acute cerebellar ataxia in children

    Directory of Open Access Journals (Sweden)

    Valeriana Moura Ribeiro

    1968-03-01

    Full Text Available São relatados os casos de 6 crianças com ataxia cerebelar aguda. Admitem os autores a presença de um fator etiológico de caráter viral comum a todos êles, discutindo os mecanismos patogênicos com base nos casos da literatura. A evolução foi favorável em todos os pacientes, com regressão completa da sintomatologia, dentro do período de 6 a 60 dias.Clinical observations of 6 children with acute cerebellar ataxia and respective laboratorial data are reported. Considerations are made in order to support the hypothesis of involving virus. The evolution of the disorder was a nonfatal one and the patients regained normal cerebellar function within a period of 6 to 60 days.

  7. Hepatite aguda colestática pelo propiltiouracil: relato de caso

    Directory of Open Access Journals (Sweden)

    PAROLIN Mônica Beatriz

    2000-01-01

    Full Text Available Propiltiouracil é uma droga amplamente utilizada no tratamento do hipertiroidismo. A hepatotoxicidade é um dos efeitos colaterais mais raros e também mais graves associados a ela. Relata-se um caso de hepatite aguda colestática que acomete um jovem de 15 anos em uso de propiltiouracil para tratamento de hipertiroidismo. Causas virais, metabólicas e autoimunes foram excluídas e a biopsia hepática revelou achados histopatológicos sugestivos de hepatite colestática induzida por droga. Com a suspensão da droga, houve remissão dos sintomas e normalização progressiva das provas de função hepática. Raramente, os pacientes em uso de propiltiouracil podem desenvolver injúria hepática grave.

  8. Leucemia Linfoblástica Aguda Caso clínico

    OpenAIRE

    Jiménez Navarro, Nuria

    2017-01-01

    El cáncer es una de las segundas causas de muerte de nuestra población considerándose también la segunda causa de muerte entre los 0-14 años de edad. Es una enfermedad multifactorial que consigue deteriorar al paciente tanto física como psíquicamente. La leucemia linfoblástica aguda es el cáncer más relevante en niños, constituyendo el 80% de los casos. Está localizado en las células sanguíneas, normalmente en los glóbulos blancos, de la médula ósea, afectando a la función inmunológica. Debid...

  9. FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2.

    Directory of Open Access Journals (Sweden)

    Maria Castella

    2015-10-01

    Full Text Available The Fanconi anemia (FA-BRCA pathway mediates repair of DNA interstrand crosslinks. The FA core complex, a multi-subunit ubiquitin ligase, participates in the detection of DNA lesions and monoubiquitinates two downstream FA proteins, FANCD2 and FANCI (or the ID complex. However, the regulation of the FA core complex itself is poorly understood. Here we show that the FA core complex proteins are recruited to sites of DNA damage and form nuclear foci in S and G2 phases of the cell cycle. ATR kinase activity, an intact FA core complex and FANCM-FAAP24 were crucial for this recruitment. Surprisingly, FANCI, but not its partner FANCD2, was needed for efficient FA core complex foci formation. Monoubiquitination or ATR-dependent phosphorylation of FANCI were not required for the FA core complex recruitment, but FANCI deubiquitination by USP1 was. Additionally, BRCA1 was required for efficient FA core complex foci formation. These findings indicate that FANCI functions upstream of FA core complex recruitment independently of FANCD2, and alter the current view of the FA-BRCA pathway.

  10. Mielitis aguda necrotizante en un paciente con Sida Acute necrotizing myelitis in an AIDS patient

    Directory of Open Access Journals (Sweden)

    M. Corti

    2003-04-01

    Full Text Available Como consecuencia de la infección por el virus de la inmunodeficiencia humana tipo-1 (HIV-1, otros patógenos como citomegalovirus (CMV y herpes simple tipo 1-2 (HSV 1-2 pueden comprometer tanto el sistema nervioso central como el periférico. Estos agentes pueden involucrar también a la médula espinal y causar una mielitis aguda necrotizante. Esta complicación ocurre por lo general en pacientes con enfermedad HIV/sida avanzada y marcada inmunodeficiencia, con recuentos de linfocitos T CD4+ de menos de 50 cél/µL. El cuadro clínico, los cambios en el LCR y las neuroimágenes generan una importante sospecha diagnóstica. Es fundamental el inicio precoz de la terapia antiviral específica. Se presenta un paciente con enfermedad avanzada debida al HIV-1 y mielitis aguda necrotizante por CMV y HSV bajo la forma clínica de síndrome de la cola de caballo.In the setting of HIV infection, cytomegalovirus (CMV and herpes simplex virus type 1-2 (HSV 1-2 can affect both the central and peripheral nervous systems. These agents can involve the spinal cord and produce a necrotizing transverse myelitis. This usually occurs in AIDS patients with severe immunodeficiency: CD4 + lymphocyte counts typically are less than 50 cell/µL. The clinical presentation, CSF and imaging studies can provide a high level of suspicion diagnosis. Prompt initiation of antiviral specific drugs is essential. We report a patient with an acute necrotizing myelitis (cauda equina syndrome secondary to CMV and HSV infections.

  11. Diabetes Mellitus en el servicio de urgencias: manejo de las complicaciones agudas en adultos

    Directory of Open Access Journals (Sweden)

    Eder A. Hernández-Ruiz

    2008-01-01

    Full Text Available La Diabetes Mellitus (DM es una enfermedad de alta prevalencia, reconocida como un problema de salud pública, debido a sus altas tasas de morbilidad y mortalidad asociadas. Diferentes estudios han documentado que la falta de adherencia al tratamiento, constituye uno de los principales factores desencadenantes para las descompensaciones agudas en el paciente diabético. Dentro del espectro de dichas alteraciones se encuentran las crisis hiperglicémicas agudas, las cuales se han dicotomizado en dos entidades clínicas: la Cetoacidosis Diabética (CAD y el Estado Hiperglicémico Hiperosmolar (EHH, que constituyen complicaciones metabólicas potencialmente fatales en el corto plazo y de las cuales pueden encontrarse cuadros superpuestos. Se han establecido criterios diagnósticos específicos buscando realizar un diagnóstico diferencial acertado, que permita un tratamiento idóneo; sin embargo, las tasas de morbilidad y mortalidad siguen siendo considerables. Por su parte, la Hipoglicemia también constituye una emergencia médica que, de no ser tratada oportunamente, puede ocasionar daño neurológico permanente e incluso la muerte. De lo anterior se deduce la importancia de que existan guías claras de manejo de estas alteraciones en todos los centros y servicios donde se preste atención médica de urgencias. Se siguen realizando investigaciones en busca de nuevas estrategias diagnósticas y terapéuticas que permitan un manejo más integral de la DM y sus complicaciones, en aras de mejorar la calidad de vida de los pacientes.

  12. Factores de riesgo de infecciones respiratorias agudas en menores de 5 años

    Directory of Open Access Journals (Sweden)

    María Eulalia Prieto Herrera

    2000-01-01

    Full Text Available Se realizó un estudio analítico, retrospectivo de casos y controles, pareado 1:1 para conocer algunos factores de riesgo de infecciones respiratorias agudas en menores de 5 años del reparto La Yaba, pertenecientes al policlínico Este de Camagüey, durante el año 1996. El universo fueron 90 niños que padecieron infecciones respiratorias agudas durante este período. La fuente de obtención de datos fue la historia clínica familiar e individual. El registro primario fue la encuesta con las variables: lactancia materna, desnutrición, enfermedades asociadas, fumador pasivo, hacinamiento. Se concluyó que la lactancia materna inadecuada (RR 12, 152, la desnutrición (RR 2, 278, la enfermedad parasitaria (RR 1, 643, el fumador pasivo (RR, 536 y el hacinamiento (RR 2, 719 se comportaron como factores de riesgo.An analytic retrospective case-control study was performed, matched 1:1, with the aim of getting to know the risk factors for acute respiratory diseases in children under 5 years of age from La Yaba neighborhood belonging to the health area of the eastern policlinics of Camaguey, during the year 1996. The study material was made up of 90 children that suffered from acute respiratory diseases during that period. The data source was the individual and family medical histories. The primary record was a survey including the following variables: breast feeding, malnutrition, associated diseases, passive smoking, overcrowding. It was concluded that inadequate breast feeding (RR 12, 152, malnutrition (RR 2, 278, parasitic disease (RR 1, 643, passive smoking (RR, 536 and overcrowding (RR 2, 719 behaved as risk factors.

  13. Nutritional support in patients with severe acute pancreatitis Soporte nutricional en pacientes con pancreatitis aguda grave

    Directory of Open Access Journals (Sweden)

    Mónica Marcela Peláez Hernández

    2007-04-01

    Full Text Available Severe acute pancreatitis is associated with a systemic inflammatory response leading to a hypermetabolic, hypercatabolic condition; for those reasons, patients suffering from this disease require an excellent artificial nutritional support in order to maintain the structural integrity and the function of vital organs with minimal pancreatic secretion. Total parenteral nutrition has been the standard practice in the treatment of patients with severe acute pancreatitis because of the favorable outcomes of early nutritional support while avoiding pancreatic stimulation; however, recent evidence suggests there are potentially greater benefits with enteral as compared with parenteral nutrition, including fewer septic and metabolic complications and lesser costs. That is why present guidelines for the management of acute pancreatitis recommend that enteral instead of parenteral nutrition be used in patients with severe acute pancreatitis. La pancreatitis aguda, especialmente en su forma grave, está asociada con una respuesta inflamatoria sistémica que lleva a un estado de hipermetabolismo e hipercatabolismo, en el que se requiere un excelente soporte nutricional que permita mantener la integridad estructural y la función de los órganos vitales con un estímulo mínimo de la secreción pancreática. La nutrición parenteral total era el soporte de elección, que permitía obtener todos los beneficios de la nutrición temprana sin estimular la secreción pancreática; pero la evidencia actual muestra mayores beneficios con la nutrición enteral, porque se asocia con menos complicaciones infecciosas y metabólicas y con disminución en los costos. Por ello las guías actuales de tratamiento de la pancreatitis aguda grave recomiendan como primera elección el soporte nutricional enteral.

  14. Crisis aguda de Asma Bronquial. Diagnóstico y tratamiento estandarizado

    Directory of Open Access Journals (Sweden)

    Anelia de la Caridad Rojas-Pérez

    2013-01-01

    Full Text Available Se realizó un estudio prospectivo de intervención en 150 pacientes con diagnóstico de Asma Bronquial que acudieron con crisis aguda al Servicio de Urgencias del Hospital Pediátrico de Holguín, de Enero del 2009 hasta Diciembre del 2010; para evaluar la evolución de los mismos después de la aplicación de Guías de Buenas Prácticas. Se aplicó tratamiento a los pacientes según lo establecido, observando su respuesta. Predominó el grupo de 4 a 8 años del sexo masculino, el 52 % de los pacientes presentaron crisis ligeras, buena respuesta al uso de broncodilatadores en aerosol, se aplicó la Prednisona por vía oral en la mayoría de los casos que lo requirieron, el 68,7 % realizó tratamiento domiciliario con respuestas controladas y solo en el 31,3 % se decidió ingreso hospitalario lo que permitió arribar a la siguiente conclusión: Con la aplicación de Guías de Buenas Prácticas Clínicas par a el manejo de la exacerbación aguda del Asma Bronquial se logró una clasificación adecuada de la severidad de la misma, buena respuesta a los tratamientos utilizados y disminución de los ingresos hospitalarios.

  15. Achados principais de exames laboratoriais no diagnóstico de apendicite aguda: uma avaliação prospectiva Main findings in laboratory tests diagnosis of acute appendicitis: a prospective evaluation

    Directory of Open Access Journals (Sweden)

    Rafael Nunes Goulart

    2012-06-01

    Full Text Available RACIONAL: Apendicite aguda é a doença abdominal cirúrgica mais comum nas unidades de emergência. Embora o diagnóstico seja clínico, a realização de exames complementares pode ser útil na dúvida diagnóstica. OBJETIVO: Avaliar as principais alterações de exames laboratoriais em pacientes com apendicite aguda, assim como sua relação com a fase evolutiva da doença. MÉTODOS: Avaliação prospectiva de pacientes com diagnóstico de apendicite aguda submetidos ao tratamento cirúrgico. RESULTADOS: Cento e setenta e nove pacientes participaram deste estudo, a maioria do sexo masculino. A idade média foi de 26 anos. Em relação à contagem de leucócitos, 46,9% apresentavam valores BACKGROUND: Acute appendicitis is the most common surgical abdominal disease in the emergency room. Although the diagnosis is clinical the complementary tests may be useful in doubt. AIM: To evaluate the main laboratory tests in patients with acute appendicitis, as well as its relationship with the evolutionary stage of the disease. METHODS: Prospective evaluation of patients with acute appendicitis who underwent surgical treatment. RESULTS: A total of 179 patients participated in this study, most were male. The mean age was 26 years. For leukocyte count 46.9% had values ​​<15.000mm3. The mean percentage of polymorphonuclear cells was 81,7%, 1,2% of sticks, 1% eosinophils, lymphocytes 12,8% and 2,9% monocytes. C-reactive protein was required for 54 patients. It was <10 mg/dl in 19, between 10 and 50 mg/dl in 24 and greater than or equal to 50 mg/dl in 11. Regarding the evolutionary phase 64% patients had early stage (stages 1 and 2, 16,2% stage 3 and 35 stage 4. A total of 57% of patients with white blood cell count greater than or equal to 20.000/mm3 had appendicular perforation (p<0,05. The percentage of polymorphonuclear leukocytes from patients with early stages was lower than the later stages (79,8% and 85,1%, respectively, with p<0,05. Patients

  16. PROFIL PROTEIN HIPOFISA SAPI PERAH PERANAKAN FRIES HOLLAND (PFH BETINA FASE FOLIKULER DAN LUTEA

    Directory of Open Access Journals (Sweden)

    Nurul Isnaini

    2012-04-01

    Full Text Available ABSTRAK   Penelitian dilakukan dengan tujuan untuk mengetahui profil protein hipofisa sapi perah PFH betina fase folikuler dan fase luteal dengan menggunakan metode SDS-PAGE. Hasil penelitian ini diharapkan dapat digunakan sebagai acuan untuk melaksanakan pengujian jenis protein tertentu yang terdapat dalam hipofisa sapi perah PFH.Materi yang digunakan dalam penelitian ini adalah hipofisa sapi perah PFH betina Fase Folikuler dan Fase Luteal. Sampel hipofisa didapatkan dari Rumah Potong Hewan (RPH Singosari Malang. Metode penelitian yang digunakan dalam penelitian ini adalah metode observasi. Dimana sampel hipofisa sapi perah PFH fase folikuler dan fase luteal dilakukan isolasi protein, dan ditentukan Berat Molekul (BM proteinnya. Data yang diperoleh dianalisis dengan menggunakan analisis diskriptif. Hasil penelitian menunjukkan bahwa profil protein hipofisa fase folikuler dan fase luteal sapi perah PFH memiliki perbedaan. Pada hipofisa fase folikuler memiliki 12 pita protein, yaitu 163; 112,3; 101,3; 85,8; 80,6; 71,2; 53,3; 45,2; 39,9; 32,4; 29,8; dan 24,8 kDa. Pada hipofisa fase luteal memiliki 12 pita protein, yaitu 163; 112,3; 101,3; 85,8; 71,2; 60,3; 53,3; 45,2; 39,9; 32,4; 29,8; dan 24,8 kDa. Pita protein yang membedakan adalah pita dengan berat molekul 80,6 kDa hanya terdapat pada hipofisa fase folikuler, dan pita dengan berat molekul 60,3 kDa hanya terdapat pada hipofisa fase luteal. Kesimpulan yang diperoleh dari penelitian ini adalah terdapat perbedaan profil protein yang dihasilkan pada hipofisa fase folikuler dengan hipofisa fase luteal. Saran yang diberikan adalah perlu dilakukan penelitian lanjutan yaitu uji immunoblothing atau westernblothing (WB untuk memastikan keberadaan  protein-protein tertentu.   Kata kunci: Hipofisa, folikuler, luteal, berat molekul protein. HIPOPHISIS PROTEIN PROFILE OF CROSSBREED FRIESH HOLLAND DAIRY CATTLE IN FOLLICULAR AND LUTEAL PHASE   ABSTRACT   The aim of this research was to identification of

  17. Alterações agudas dos níveis de neurotransmissores em corpo estriado de ratos jovens após estado epiléptico induzido por pilocarpina Acute alterations of neurotransmitters levels in striatum of young rat after pilocarpine-induced status epilepticus

    Directory of Open Access Journals (Sweden)

    Rivelilson Mendes de Freitas

    2003-06-01

    Full Text Available Altas doses de agonista colinérgico muscarínico, pilocarpina, produzem alterações comportamentais, convulsões e estado epiléptico em ratos. O objetivo desse estudo foi verificar as alterações nas concentrações dos neurotransmissores em corpo estriado de ratos em desenvolvimento após estado epiléptico induzido pela pilocarpina. Ratas Wistar foram tratadas com uma única dose de pilocarpina (400mg/Kg; s.c.. Controles receberam salina. A concentração dos neurotransmissores foi determinada através do HPLC, no corpo estriado de ratos que no período de observação de 1 e 24h desencadearam estado epiléptico e não sobreviveram à fase aguda do quadro convulsivo. Foi observada redução nos níveis de dopamina, serotonina, ácido dihidroxifenilacético, ácido 5-hidroxiindolacético, e aumento no ácido 4-hidroxi-3-metoxi-fenilacético. Os resultados mostraram que a ativação do sistema colinérgico pode interagir com os sistemas dopaminérgico e serotonérgico nos mecanismos referentes à fase aguda do processo convulsivo.High doses of the muscarinic cholinergic agonist, pilocarpine, result in behavioural changes, seizures and status epilepticus in rats. The purpose of the present work is to invetigate the striatal neurotransmissors level in young rats after status epilepticus induced by pilocarpine. Wistar rats were treated with a single dose of pilocarpine (400mg/Kg; s.c.. Controls received saline. Young animals were closed observed for behavioural changes during 1 and 24h. In these periods, the animals that developed status epilepticus and didn't survive this acute phase of seizures had the brains removed and striatal neurotransmissors level determined by HPLC. The concentration of dopamine, serotonine, dihydroxyphenylacetic acid, 5-hydroxyindolacetic acid was reduced and an increase in 4-hydroxy-3-methoxy-phenylacetic acid was observed. These results suggest that cholinergic activation can interage with dopaminergic and

  18. The cathepsin B inhibitor, z-FA-CMK is toxic and readily induced cell death in human T lymphocytes

    International Nuclear Information System (INIS)

    Liow, K.Y.; Chow, S.C.

    2013-01-01

    The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-chloromethylketone (z-FA-CMK) was found to be toxic and readily induced cell death in the human T cell line, Jurkat, whereas two other analogs benzyloxycarbonyl-phenylalanine-alanine-fluoromethylketone (z-FA-FMK) and benzyloxycarbonyl-phenylalanine-alanine-diazomethylketone (z-FA-DMK) were not toxic. The toxicity of z-FA-CMK requires not only the CMK group, but also the presence of alanine in the P1 position and the benzyloxycarbonyl group at the N-terminal. Dose–response studies showed that lower concentrations of z-FA-CMK induced apoptosis in Jurkat T cells whereas higher concentrations induced necrosis. In z-FA-CMK-induced apoptosis, both initiator caspases (-8 and -9) and effector caspases (-3, -6 and -7) were processed to their respective subunits in Jurkat T cells. However, only the pro-form of the initiator caspases were reduced in z-FA-CMK-induced necrosis and no respective subunits were apparent. The caspase inihibitor benzyloxycarbonyl-valine-alanine-aspartic acid-(O-methyl)-fluoromehylketone (z-VAD-FMK) inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentration of z-FA-CMK but has no effect on z-FA-CMK-induced necrosis and the loss of initiator caspases. This suggests that the loss of initiator caspases in Jurkat T cells during z-FA-CMK-induced necrosis is not a caspase-dependent process. Taken together, we have demonstrated that z-FA-CMK is toxic to Jurkat T cells and induces apoptosis at low concentrations, while at higher concentrations the cells die of necrosis. - Highlights: • z-FA-CMK is toxic and induce cell death in the human T cells. • z-FA-CMK toxicity requires the CMK group, alanine and the benzyloxycarbonyl group. • z-FA-CMK induced apoptosis at low concentration and necrosis at high concentration

  19. The cathepsin B inhibitor, z-FA-CMK is toxic and readily induced cell death in human T lymphocytes

    Energy Technology Data Exchange (ETDEWEB)

    Liow, K.Y.; Chow, S.C., E-mail: chow.sek.chuen@monash.edu

    2013-11-01

    The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-chloromethylketone (z-FA-CMK) was found to be toxic and readily induced cell death in the human T cell line, Jurkat, whereas two other analogs benzyloxycarbonyl-phenylalanine-alanine-fluoromethylketone (z-FA-FMK) and benzyloxycarbonyl-phenylalanine-alanine-diazomethylketone (z-FA-DMK) were not toxic. The toxicity of z-FA-CMK requires not only the CMK group, but also the presence of alanine in the P1 position and the benzyloxycarbonyl group at the N-terminal. Dose–response studies showed that lower concentrations of z-FA-CMK induced apoptosis in Jurkat T cells whereas higher concentrations induced necrosis. In z-FA-CMK-induced apoptosis, both initiator caspases (-8 and -9) and effector caspases (-3, -6 and -7) were processed to their respective subunits in Jurkat T cells. However, only the pro-form of the initiator caspases were reduced in z-FA-CMK-induced necrosis and no respective subunits were apparent. The caspase inihibitor benzyloxycarbonyl-valine-alanine-aspartic acid-(O-methyl)-fluoromehylketone (z-VAD-FMK) inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentration of z-FA-CMK but has no effect on z-FA-CMK-induced necrosis and the loss of initiator caspases. This suggests that the loss of initiator caspases in Jurkat T cells during z-FA-CMK-induced necrosis is not a caspase-dependent process. Taken together, we have demonstrated that z-FA-CMK is toxic to Jurkat T cells and induces apoptosis at low concentrations, while at higher concentrations the cells die of necrosis. - Highlights: • z-FA-CMK is toxic and induce cell death in the human T cells. • z-FA-CMK toxicity requires the CMK group, alanine and the benzyloxycarbonyl group. • z-FA-CMK induced apoptosis at low concentration and necrosis at high concentration.

  20. New methods for testing fire resistance of wood façade systems

    Directory of Open Access Journals (Sweden)

    Mårtensson August

    2016-01-01

    Full Text Available Arson in schools has been a huge problem in Sweden over the last fifteen years. The average amount of school arsons between 2000 and 2014 was 285 cases each year which corresponds to 50% of the total amount of reported fires in school buildings. This is a well-known problem and a lot of research has been done in this area. Investigations has been done about fire and heat detection systems, different technical factors significance in fire scenarios and how to prevent adolescents from starting fires. Another part of the problem that partly been investigated is how the schools are constructed. Roughly 50% of the arsons are outside of the school building. In Sweden one and two storey buildings are allowed to be built with wooden façades in accordance with the building code, which is one of the reasons many schools are built with wooden façade systems. The most critical part in a wood façade system from a fire safety perspective is concluded to be the eaves because of how they usually are built to let air pass through. Even though a wood façade isn't as well resistant to fire compared to a concrete façade, three versions of new test methods for combustible façades have been developed to make it possible to make sure in advance that a construction is resistant enough. The new test methods are focused on specific details and parts of a façade system to provide a more informative and useful result compared to SP Fire 105. Observations and measurements of flame spread and temperature changes in the eave, over the window joints and in the air gap are made. With these parameters in consideration criteria's has been chosen for a critical temperature of 280 ∘C at a critical time of 20 minutes.

  1. The effect of architectural façade design on energy savings in the student dormitory

    Directory of Open Access Journals (Sweden)

    Pejić Petar Č.

    2014-01-01

    Full Text Available There are many reasons for adequate use of natural light inside students' dormitories. Intensity of light required for student activities and temperature inside the rooms are the major factors for an occupant's comfortable work and life. Design of building façades has a significant impact both on the use of natural light and energy consumption. In this paper, a comparative analysis of student rooms with different orientations and different façade designs was performed in order to investigate what type of refurbishment in the façade is necessary. The goal of the refurbishment was generation of optimal thermal and lighting comfort for students' work with maximal energy saving for a new student dormitory in Nis, Serbia. An analysis of annual energy consumption of the newly designed student dormitory and proposed replacements on the exterior façade was performed by using the software EnergyPlus. Based on the energy consumption analysis it could be concluded that significant energy savings would be possible by upgrading the shading devices across the width of the window. In other words, changing the façade of the dorm could generally improve students' comfort, while the energy costs would be reduced. [Projekat Ministarstva nauke Republike Srbije, br. TR 36037: Development of student dorms in Serbia at the beginning of the 21st century i br. TR 33051: The concept of sustainable energy supply of settlements with energy efficient buildings

  2. Fitness costs and stability of Cry1Fa resistance in Brazilian populations of Spodoptera frugiperda.

    Science.gov (United States)

    Santos-Amaya, Oscar F; Tavares, Clébson S; Rodrigues, João Victor C; Campos, Silverio O; Guedes, Raul Narciso C; Alves, Analiza P; Pereira, Eliseu José G

    2017-01-01

    The presence of fitness costs of resistance to Bacillus thuringiensis (Bt) insecticidal proteins in insect populations may delay or even reverse the local selection of insect resistance to Bt transgenic crops, and deserves rigorous investigation. Here we assessed the fitness costs associated with Cry1Fa resistance in two strains of fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae), derived from field collections in different Brazilian regions and further selected in the laboratory for high levels of resistance to Cry1Fa using leaves of TC1507 corn. Fitness components were compared using paired resistant and susceptible strains with similar genetic backgrounds and F 1 generations from reciprocal crosses, all of them reared on non-transgenic corn leaves. No apparent life history costs in the larval stage were observed in the Bt-resistant strains. Moreover, the resistance remained stable for seven generations in the absence of selection, with no decrease in the proportion of resistant individuals. Larval respiration rates were also similar between resistant and susceptible homozygotes, and heterozygotes displayed respiration rates and demographic performance equal or superior to those of susceptible homozygotes. In combination, these results indicate the lack of strong fitness costs associated with resistance to Cry1Fa in the fall armyworm strains studied. These findings suggest that Cry1Fa resistance in S. frugiperda populations is unlikely to be counterselected in Cry1Fa-free environments. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.

  3. Multi-angled Façade System for Office Building Renovation

    DEFF Research Database (Denmark)

    Hannoudi, Loay Akram; Christensen, Jørgen Erik; Lauring, Michael

    renovating office buildings. The architectural potential is presented with the help of AutoCAD software. The energy efficiency and indoor climate are investigated and evaluated by using correlational research and simulation research methods with the software IDA ICE. From a functional perspective, the multi......-angled façade increases the area of the office room and provides more space. There are many potential aesthetic benefits provided by multi-angled façades such as improved optical and visual quality from inside the office room and the possibility for daylight penetration and a view to outside from one part...... compared to a renovated flat façade varies between 4.9 and 6.5 kWh/(m2.year), depending on the orientation of the façade. The increase in the office room area, when renovated with a multi-angled façade, is by 19%, while the increase of the yearly primary energy consumption (not area weighted), is by 4...

  4. AppFA: A Novel Approach to Detect Malicious Android Applications on the Network

    Directory of Open Access Journals (Sweden)

    Gaofeng He

    2018-01-01

    Full Text Available We propose AppFA, an Application Flow Analysis approach, to detect malicious Android applications (simply apps on the network. Unlike most of the existing work, AppFA does not need to install programs on mobile devices or modify mobile operating systems to extract detection features. Besides, it is able to handle encrypted network traffic. Specifically, we propose a constrained clustering algorithm to classify apps network traffic, and use Kernel Principal Component Analysis to build their network behavior profiles. After that, peer group analysis is explored to detect malicious apps by comparing apps’ network behavior profiles with the historical data and the profiles of their selected peer groups. These steps can be repeated every several minutes to meet the requirement of online detection. We have implemented AppFA and tested it with a public dataset. The experimental results show that AppFA can cluster apps network traffic efficiently and detect malicious Android apps with high accuracy and low false positive rate. We have also tested the performance of AppFA from the computational time standpoint.

  5. Application and properties of pure lime façades - case study

    Directory of Open Access Journals (Sweden)

    Violeta Bokan Bosiljkov

    2008-01-01

    Full Text Available The paper presents experiences obtained during application and testing of different pure lime façades that could be successfully used in restoration of historical buildings in Slovenia. The lime façade consists of a rendering layer (rough mortar, a finishing layer (fine mortar and a protective layer of lime wash. For the design of the mortars different industrially and traditionally produced limes were chosen, based on the results of preliminary studies of the authors and experiences of a small enterprise (SE involved in the study. The façade layers were applied to the most problematic northern wall of the historic chapel made from rubble masonry. The chapel belongs to the castle Crnelo, built at the end of the 17th century in the village Turnše, not far from Ljubljana, the capital of Slovenia. The façade layers were made by skilled workers of SE, with about one year time difference between application of rendering and finishing layers, and with a protective layer of coloured lime wash applied to one to three day old finishing layers. On the rendering layers, visual inspection, water absorption tests and determination of carbonation depth were carried out before subsequent finishing layers were applied. The same on-site tests were carried out also on finished façade layers. So far, parallel to the on-site tests, compressive and water absorption tests on prisms prepared from rough mortars were carried out in laboratory.

  6. Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent

    Science.gov (United States)

    Jeppesen, J.; Albers, P. H.; Rose, A. J.; Birk, J. B.; Schjerling, P.; Dzamko, N.; Steinberg, G. R.; Kiens, B.

    2011-01-01

    The aim of this study was to investigate the molecular mechanisms regulating FA translocase CD36 (FAT/CD36) translocation and FA uptake in skeletal muscle during contractions. In one model, wild-type (WT) and AMP-dependent protein kinase kinase dead (AMPK KD) mice were exercised or extensor digitorum longus (EDL) and soleus (SOL) muscles were contracted, ex vivo. In separate studies, FAT/CD36 translocation and FA uptake in response to muscle contractions were investigated in the perfused rat hindlimb. Exercise induced a similar increase in skeletal muscle cell surface membrane FAT/CD36 content in WT (+34%) and AMPK KD (+37%) mice. In contrast, 5-aminoimidazole-4-carboxamide ribonucleoside only induced an increase in cell surface FAT/CD36 content in WT (+29%) mice. Furthermore, in the perfused rat hindlimb, muscle contraction induced a rapid (1 min, +15%) and sustained (10 min, +24%) FAT/CD36 relocation to cell surface membranes. The increase in cell surface FAT/CD36 protein content with muscle contractions was associated with increased FA uptake, both in EDL and SOL muscle from WT and AMPK KD mice and in the perfused rat hindlimb. This suggests that AMPK is not essential in regulation of FAT/CD36 translocation and FA uptake in skeletal muscle during contractions. However, AMPK could be important in regulation of FAT/CD36 distribution in other physiological situations. PMID:21297178

  7. Chao Fa Movies: The Transnational Production of Hmong American History and Identity by Ian G. Baird

    Directory of Open Access Journals (Sweden)

    Ian Baird

    2014-12-01

    Full Text Available Films made by and for particular social and ethnic peoples can reveal a great deal about identity issues. Here, I examine the cultural production, the content, and the socio-cultural and political significance of three Chao Fa-inspired Hmong films produced at Khek Noi, Thailand by Hmong American producers working with largely Hmong Thai actors. The first two, Chao Fa 1 and 2, were directed in 2009 by Kou Thao. The third, Vaj Tuam Thawj – The Legend of Chao Fa, was put together by Jimmy Vang, in 2010. Even though these Chao Fa films are fictional, they attempt to depict events and circumstances that are familiar to many first generation Hmong Americans, and they can muster strong emotions from people who see them as depicting factual history. In addition, just like many other American youth, many 1.5 generation Hmong are tied together by shared media experiences, including Hmong movies. Thus, the Chao Fa movies are important for producing and reproducing, reinforcing and dispersing ideas related to Hmong American identity and culture. They tell stories of the Hmong being oppressed by many different groups, and this history suggests why many Hmong—not only the Chao Fa—have long desired the type of independence and freedom from prejudice and discrimination that they imagine would come if the Hmong only had their own nation state.

  8. Evaluated experimental database on critical heat flux in WWER FA models

    International Nuclear Information System (INIS)

    Artamonov, S.; Sergeev, V.; Volkov, S.

    2015-01-01

    The paper presents the description of the evaluated experimental database on critical heat flux in WWER FA models of new designs. This database was developed on the basis of the experimental data obtained in the years of 2009-2012. In the course of its development, the database was reviewed in terms of completeness of the information about the experiments and its compliance with the requirements of Rostekhnadzor regulatory documents. The description of the experimental FA model characteristics and experimental conditions was specified. Besides, the experimental data were statistically processed with the aim to reject incorrect ones and the sets of experimental data on critical heat fluxes (CHF) were compared for different FA models. As a result, for the fi rst time, the evaluated database on CHF in FA models of new designs was developed, that was complemented with analysis functions, and its main purpose is to be used in the process of development, verification and upgrading of calculation techniques. The developed database incorporates the data of 4183 experimental conditions obtained in 53 WWER FA models of various designs. Keywords: WWER reactor, fuel assembly, CHF, evaluated experimental data, database, statistical analysis. (author)

  9. A BPMN-Based Process Map for the Design and Construction of Façades

    Directory of Open Access Journals (Sweden)

    Eleanor Voss

    2013-12-01

    Full Text Available Process mapping can lead to significant efficiency and quality improvements in construction engineering and is an ideal basis for developing IT support tools. The increasing complexity and multidisciplinary nature of façade design and construction suggest that a process map would be beneficial in this sector of the construction industry, but it has received limited attention to date. This paper presents a verified process map of the façade design and construction process.  The map is the first of its kind to represent, in detail, the whole process relevant to all façade types, from commencement of the façade consultant’s and contactor’s participation, to the end of their involvement. The paper describes the process by which the mapping notation was selected, followed by the development and verification of the process map, including testing in two independent research projects. The BuildingSMART’s BPMN notation is found to have superior system features and comprehensibility for this application and the resulting process map is easy to interpret and verify by industry experts. The trialling of the map in the two research projects indicate that the map is a useful tool for assessing process improvements in the façades sector.

  10. Le «segmentateur» fa-(’inna en arabe classique et moderne

    Directory of Open Access Journals (Sweden)

    Pierre Larcher

    2006-01-01

    Full Text Available Fa- is generally described as a connective particle and, when linked to ’inna, as the equivalent of the French car, the Italian giacché, the German denn or the English for. However, in Classical Arabic, the so-called “fa- of the apodosis”, often connected to ’inna, seems to function in a syntactically as well as in a semantically different way. In Modern Standard Arabic, fa-(’inna appears systematically not only after conditional clauses, but also after concessive, causal, final clauses and, more generally, after any expression having the value of a subordinate clause. Therefore, fa- is the mark of what the Swiss linguist Charles Bally (1865-1947 called “segmentation” (vs. coordination. This apparently double function of fa-(’inna is actually a single one: in both cases, it separates the topic from the comment. The difference is that in the first case the topic is a whole sentence, whereas in the second it is a segment (clause or phrase of the sentence itself.

  11. Physical interaction between the strawberry allergen Fra a 1 and an associated partner FaAP: Interaction of Fra a 1 proteins and FaAP.

    Science.gov (United States)

    Franz-Oberdorf, Katrin; Langer, Andreas; Strasser, Ralf; Isono, Erika; Ranftl, Quirin L; Wunschel, Christian; Schwab, Wilfried

    2017-10-01

    The strawberry fruit allergens Fra a 1.01E, Fra a 1.02 and Fra a 1.03 belong to the group of pathogenesis-related 10 (PR-10) proteins and are homologs of the major birch pollen Bet v 1 and apple allergen Mal d 1. Bet v 1 related proteins are the most extensively studied allergens but their physiological function in planta remains elusive. Since Mal d 1-Associated Protein has been previously identified as interaction partner of Mal d 1 we studied the binding of the orthologous Fra a 1-Associated Protein (FaAP) to Fra a 1.01E/1.02/1.03. As the C-terminal sequence of FaAP showed strong auto-activation activity in yeast 2-hybrid analysis a novel time resolved DNA-switching system was successfully applied. Fra a 1.01E, Fra a 1.02, and Fra a 1.03 bind to FaAP with K D of 4.5 ± 1.1, 15 ± 3, and 11 ± 2 nM, respectively. Fra a 1.01E forms a dimer, whereas Fra a 1.02 and Fra a 1.03 bind as monomer. The results imply that PR-10 proteins might be integrated into a protein-interaction network and FaAP binding appears to be essential for the physiological function of the Fra a 1 proteins. © 2017 Wiley Periodicals, Inc.

  12. Evaluation of digesters in the Netherlands. Phase 2; Evaluatie van de vergisters in Nederland. Fase 2

    Energy Technology Data Exchange (ETDEWEB)

    Velghe, F.; Wierinck, I. [Organic Waste Systems, Gent (Belgium)

    2013-10-15

    The goal of phase 1 was mapping the digestion sector, including the current bottlenecks. All digestion plants with a grant decision by NL Agency were contacted to support this study. 79 plant operators participated to the comprehensive questionnaire. The phase 1 study relates to the year 2010 and consequently does not include new developments such as green gas. In this report (phase 2) the results of monitoring of 20 digesters for a year are presented. The focus was on cost effectiveness and optimization of the digestion process [Dutch] Een gezonde en kosteneffectieve vergistingssector is van belang voor verdere ontwikkeling van de vergistingsketen. De basis voor deze inventarisatie was een enquete (fase 1). Dat rapport baseerde zich op gegevens van installaties die in 2010 volledig in bedrijf waren. In fase 2 is een twintigtal vergisters een jaar lang gemonitord. De nadruk ligt hier op het verbeteren van de kosteneffectiviteit van het vergistingproces door procesoptimalisatie.

  13. Facial electroneurography in Bell's palsy: variability in the early stage and comparison between interpretation methods Eletroneurografia do nervo facial na paralisia de Bell: variabilidade na fase aguda e comparação entre técnicas

    Directory of Open Access Journals (Sweden)

    Jovany Luis Alves de Medeiros

    1996-09-01

    Full Text Available To determine the variability of the abnormalities found in the electroneurography (ENG of the facial nerve in cases of Bell's palsy during the initial two week period was one of the objectives of the authors. A second one was to investigate the value of ENG as a tool to determine an early prognosis of recovery utilizing two different methods. In the first one the amplitude of the compound muscular action potential (CMAP obtained on the paralyzed side was compared to this potential on the opposite (normal side. The second method compared the CMAP on the paralyzed side to normal standardized data from normal individuals. A group of 33 patients with Bell's palsy was followed until total recovery or for at least 4 months, if the recovery was not achieved earlier. It was observed that amplitude of the CMAP become stable towards the sixth day of palsy and this is a good time to establish the prognosis. Another conclusion is that both methods were equivalent to determine the prognosis in Bell's palsy.O objetivo deste trabalho é determinar a variabilidade da eletroneurografia (ENG do nervo facial na paralisia de Bell durante as primeiras duas semanas e investigar o valor da ENG na determinação de um prognóstico precoce utilizando-se dois métodos diferentes. O primeiro método compara a amplitude do potencial de ação muscular composto obtido no lado paralisado com o lado normal e o segundo método compara o potencial de ação muscular composto obtido no lado paralisado com valores normativos. Um grupo de 33 pacientes com paralisia de Bell foi seguido até a recuperação total ou pelo menos por quatro meses nos casos em que não houve recuperação. Observou-se que a amplitude do potencial de ação muscular composto estabiliza-se em torno do sexto dia e que este é um bom momento para se realizar o exame e se estabelecer um prognóstico. Outra conclusão é que ambos os métodos são equivalentes para determinação prognóstica.

  14. Global Aphasia As A Predictor Of Mortality In The Acute Phase Of A First Stroke [afasia Global Prediz Mortalidade Na Fase Aguda De Um Primeiro Acidente Vascular Cerebral Isquêmico

    OpenAIRE

    de Oliveira F.F.; Damasceno B.P.

    2011-01-01

    OBJECTIVE: To establish whether vascular aphasic syndromes can predict stroke outcomes. METHOD: Thirty-seven adults were evaluated for speech and language within 72 hours after a single first-ever ischemic brain lesion, in blind association to CT and/or MR. RESULTS: Speech or language disabilities were found in seven (87.5%) of the eight deceased patients and twenty-six (89.7%) of the twenty-nine survivors. Global aphasia was identified in eleven patients, all with left hemisphere lesions (ni...

  15. Obtención del punto de equilibrio de reacciones en fase gaseosa

    Directory of Open Access Journals (Sweden)

    M. Ewerts S.

    2009-05-01

    Full Text Available Castellan (Physical Chenaistry, la ed, . p 214 indica un método gráfico para hallar la coordenada de reacción a partir de los potenciales químicos Lt(T,P para una reacción en fase gaseosa. El método, que posiblemente se presta bien al estudio de equilibrios simples, esincómodo cuando se quiere aplicar por ejemplo a la reacción.

  16. Obtención del punto de equilibrio de reacciones en fase gaseosa

    OpenAIRE

    Ewerts S., M.

    2009-01-01

    Castellan (Physical Chenaistry, la ed, . p 214) indica un método gráfico para hallar la coordenada de reacción a partir de los potenciales químicos Lt(T,P) para una reacción en fase gaseosa. El método, que posiblemente se presta bien al estudio de equilibrios simples, esincómodo cuando se quiere aplicar por ejemplo a la reacción.

  17. Cálculo termodinámico de los diagramas de fases

    OpenAIRE

    Pena, Pilar; Aza Pendas, Salvador de

    1980-01-01

    Partiendo del concepto de energía libre de Gibbs como criterio de equilibrio^e hace una breve introducción sobre las posibilidades de los métodos termodinámicos para el calculo de los diagramas de equilibrio de fases. A continuación se presentan varias aplicaciones concretas para la constmcción de diagramas binarios del tipo de solubilidad sólida completa y del tipo eutéctico.

  18. NGAL urinária em pacientes sem e com lesão renal aguda em unidade de terapia intensiva

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    Mirian Watanabe

    2014-12-01

    Full Text Available Objetivo: Avaliar a eficácia diagnóstica e prognóstica da lipocalina associada à gelatinase neutrofílica urinária em pacientes de unidade de terapia intensiva. Métodos: Estudo do tipo coorte, prospectivo, longitudinal desenvolvido em uma unidade de terapia intensiva clínica especializada em cardiologia. Os pacientes foram estratificados segundo os grupos sem e com lesão renal aguda, acompanhados a partir das primeiras 24 horas de internação até a alta hospitalar ou óbito. A creatinina sérica, o fluxo urinário e a lipocalina associada à gelatinase neutrofílica urinária foram coletadas em dois períodos: 24 horas e 48 horas de admissão. Resultados: Foram avaliados 83 pacientes clínicos da unidade de terapia intensiva, com predomínio do gênero masculino (57,8%. Os pacientes foram agrupados em sem lesão renal aguda (N=18, com lesão renal aguda (N=28 ou com lesão renal aguda grave (N=37. Entre os pacientes com lesão renal aguda e lesão renal aguda grave, foram prevalentes os portadores de doenças crônicas, em uso de ventilação mecânica e em terapia de substituição renal, além daqueles com maiores taxas de permanência na unidade de terapia intensiva e hospitalar, e maior mortalidade. O grupo com lesão renal aguda não apresentou alteração significativa da creatinina sérica nas primeiras 24 horas na unidade de terapia intensiva, apesar dos níveis elevados de lipocalina associada à gelatinase neutrofilica urinária demonstrados nos grupos com lesão renal aguda e lesão renal aguda grave (p<0,001. Níveis elevados de lipocalina associada à gelatinase neutrofílica urinária na amostra foram associados ao óbito. Conclusão: A elevação nos níveis de lipocalina associada à gelatinase neutrofílica urinária antecede as variações da creatinina sérica em pacientes com lesão renal aguda e pode ser associada ao óbito.

  19. Método para Medir Indirectamente la Velocidad de Fase en Sensores Surface Acoustic Wave

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    Leonardo Andrés Pérez

    2015-10-01

    Full Text Available El sensor de temperatura Surface Acoustic Wave (SAW ofrece amplias posibilidades para ser utilizado en ambientes hostiles. En teoría, las mediciones del SAW se pueden leer inalámbricamente sin integrar circuitos electrónicos en su estructura, permitiendo funcionalidades en mediciones a muy altas temperaturas. La literatura reporta que las variaciones de temperatura del SAW ocasionan corrimientos en su frecuencia de sincronismo, efecto que se atribuye a la sensibilidad térmica de la velocidad de fase del substrato piezoeléctrico. Caracterizar  apropiadamente el SAW requiere una buena medición de la velocidad de fase. No obstante, medir esta velocidad con respecto a la temperatura no es posible con la instrumentación actual. Este artículo reporta un método indirecto para medir estas variaciones de velocidad a través de  simulaciones basadas en el Modelo de Mason y mediciones de la respuesta en frecuencia de un prototipo SAW. Identificar la velocidad de fase del SAW conlleva a graficar, con aceptable precisión, la curva de funcionamiento del sensor, la cual puede utilizarse posteriormente como curva de calibración.

  20. Cloning and expression analysis of FaPR-1 gene in strawberry

    Science.gov (United States)

    Mo, Fan; Luo, Ya; Ge, Cong; Mo, Qin; Ling, Yajie; Luo, Shu; Tang, Haoru

    2018-04-01

    The FaPR-1 gene was cloned by RT-PCR from `Benihoppe' strawberry and its bioinformatics analysis was conducted. The results showed that the open reading frame was 483 bp encoding encoding l60 amino acids which protein molecular weight and theoretical isoelectricity were 17854.17 and 8.72 respectively. Subcellular localization prediction shows that this gene is located extracellularly. By comparing strawberry FaPR-l and other plant Pathogenesis-related protein, homology and phylogenetic tree construction showed that the homology with grapes, peach is relatively close. In the treatments of ABA, sucrose and the mixture of the two, the expression of FaPR-1 in strawberry fruit were significantly increased.

  1. [Data mining analysis of professor Li Fa-zhi AIDS itchy skin medical record].

    Science.gov (United States)

    Wang, Dan-Ni; Li, Zhen; Xu, Li-Ran; Guo, Hui-Jun

    2013-08-01

    Analysis of professor Li Fa-zhi in the treatment of AIDS drug laws of itchy skin, provide the corresponding drug reference basis for Chinese medicine treatment of AIDS, skin itching. By using the method of analyzing the complex network of Weishi county, Henan in 2007 October to 2011 July during an interview with professor Li Fa-zhi treatment of AIDS patients with skin pruritus, etiology and pathogenesis analysis, skin itching AIDS syndrome differentiation of old Chinese medicine treatment and medication rule. The use of multi-dimensional query analysis, core drug skin itching AIDS treatment in this study as a windbreak, cicada slough, bupleurum, Qufeng solution table drug, licorice detoxification efficacy of drugs, Radix Scutellariae, Kochia scoparia, clearing away heat and promoting diuresis medicine; core prescription for Jingfang San streak virus. Professor Li Fa-zhi treatment of AIDS in the skin itching Qufeng solution table dehumidification antipruritic treatment.

  2. Altered Rhythms. Urban façades in post-war Milan

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    Magda Mària Serrano

    2017-10-01

    Full Text Available Urban façades are the outward manifestation of the character of a city, and are composed of elements that respond to rhythmic sequences in consonance with the internal order of the rooms behind them. In post-war Milan, façades were used as a field of experimentation by a group of architects, some of whom were also artists and designers, who saw themselves and can be seen as ambassadors for the future modernity of a city devastated by war. This article explains how the urban façades of Milan, based as they were on the themes drawn from the Italian compositional tradition, offer a wide variety of elements, figures and rhythms, altering and transgressing the compositional canons through the use of mechanisms that in some cases are closer to painting or sculpture than to architecture.

  3. The influence of ventilated façade on sound insulation properties of envelope walls

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    Fišarová Zuzana

    2017-01-01

    Full Text Available Presented article deals with sound insulation properties of timber structures’ envelope walls. Particularly, the influence of heavy board ventilated façade on laboratory airborne sound insulation R and Rw in dB was studied. The installation method and gaps between façade boards can cause building defects originating in overrating the influence of ventilated cladding on envelope wall acoustic parameters. Real constructions were built for the experimental purposes and measurements, one with gaps between boards and one with simply eliminated gaps for mutual comparison. The results obtained were processed to make tables and graphs and to derive recommendations for the design of this type of constructions involving the general installation method of façade boards. Detailed results are depicted in conclusions.

  4. Flight Tests of a Ministick Controller in an F/A-18 Airplane

    Science.gov (United States)

    Stoliker, Patrick C.; Carter, John

    2003-01-01

    In March of 1999, five pilots performed flight tests to evaluate the handling qualities of an F/A-18 research airplane equipped with a small-displacement center stick (ministick) controller that had been developed for the JAS 39 Gripen airplane (a fighter/attack/ reconnaissance airplane used by the Swedish air force). For these tests, the ministick was installed in the aft cockpit (see figure) and production support flight control computers (PSFCCs) were used as interfaces between the controller hardware and the standard F/A-18 flight-control laws. The primary objective of the flight tests was to assess any changes in handling qualities of the F/A-18 airplane attributable to the mechanical characteristics of the ministick. The secondary objective was to demonstrate the capability of the PSFCCs to support flight-test experiments.

  5. Asma aguda em adultos na sala de emergência: o manejo clínico na primeira hora

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    DALCIN PAULO DE TARSO ROTH

    2000-01-01

    Full Text Available Asma é doença com alta prevalência em nosso meio e ao redor do mundo. Embora novas opções terapêuticas tenham sido recentemente desenvolvidas, parece haver aumento mundial na sua morbidade e mortalidade. Em muitas instituições, as exacerbações asmáticas ainda constituem emergência médica muito comum. As evidências têm demonstrado que a primeira hora no manejo da asma aguda na sala de emergência concentra decisões cruciais que podem determinar o desfecho desta situação clínica. Nesta revisão não-sistemática, os autores enfocaram a primeira hora da avaliação e tratamento do paciente com asma aguda na sala de emergência, descrevendo uma estratégia apropriada para o seu manejo. São consideradas as seguintes etapas: diagnóstico, avaliação da gravidade, tratamento farmacológico, avaliação das complicações e decisão sobre onde se realizará o tratamento adicional. Espera-se que estas recomendações contribuam para que o médico clínico tome a decisão apropriada na primeira hora do manejo da asma aguda.

  6. Detecting blind building façades from highly overlapping wide angle aerial imagery

    Science.gov (United States)

    Burochin, Jean-Pascal; Vallet, Bruno; Brédif, Mathieu; Mallet, Clément; Brosset, Thomas; Paparoditis, Nicolas

    2014-10-01

    This paper deals with the identification of blind building façades, i.e. façades which have no openings, in wide angle aerial images with a decimeter pixel size, acquired by nadir looking cameras. This blindness characterization is in general crucial for real estate estimation and has, at least in France, a particular importance on the evaluation of legal permission of constructing on a parcel due to local urban planning schemes. We assume that we have at our disposal an aerial survey with a relatively high stereo overlap along-track and across-track and a 3D city model of LoD 1, that can have been generated with the input images. The 3D model is textured with the aerial imagery by taking into account the 3D occlusions and by selecting for each façade the best available resolution texture seeing the whole façade. We then parse all 3D façades textures by looking for evidence of openings (windows or doors). This evidence is characterized by a comprehensive set of basic radiometric and geometrical features. The blindness prognostic is then elaborated through an (SVM) supervised classification. Despite the relatively low resolution of the images, we reach a classification accuracy of around 85% on decimeter resolution imagery with 60 × 40 % stereo overlap. On the one hand, we show that the results are very sensitive to the texturing resampling process and to vegetation presence on façade textures. On the other hand, the most relevant features for our classification framework are related to texture uniformity and horizontal aspect and to the maximal contrast of the opening detections. We conclude that standard aerial imagery used to build 3D city models can also be exploited to some extent and at no additional cost for facade blindness characterisation.

  7. Leucemia mielóide aguda Ph1-positivo de novo ou crise blástica de leucemia mielóide crônica? Análise molecular e evolução clínica de um caso Molecular analysis and clinical evolution of one case of Ph1-positive acute myeloid leukemia (AML

    Directory of Open Access Journals (Sweden)

    G.W.B. Colleoni

    1998-09-01

    Full Text Available Os autores relatam um caso de leucemia mielóide aguda (LMA que apresentava, ao diagnóstico, basofilia no sangue periférico e cariótipo com presença do cromossomo Filadélfia (Ph1. Após um ano de tratamento com quimioterapia intensiva e em fase de remissão clínica e hematológica, a análise molecular pela técnica da reação em cadeia da polimerase-transcriptase reversa (RT-PCR revelou presença de doença residual (rearranjo b2-a2. A seguir, o paciente apresentou primeira recidiva como LMA e, após a remissão, evoluiu com quadro hematológico sugestivo de leucemia mielóide crônica (LMC em fase crônica. Após dez meses, apresentou nova recidiva da LMA. Os autores discutem a dificuldade do diagnóstico diferencial entre LMA Ph1-positivo de novo e crise blástica mielóide como primeira manifestação clínica da LMC, baseados nos aspectos clínicos e moleculares.A case of AML presented with basophilia in peripheral blood and Ph1 chromosome in karyotype analysis is reported. After one year of treatment with intensive chemoterapy and clinical and hematological remission, molecular analysis (RT-PCR detected minimal residual disease (b2-a2 rearrangement. Thus, the patient relapsed as AML and, after second remission, he developed a hematological picture of chronic CML. Ten months later, he relapsed again as AML. The difficulties of diagnosis between AML Ph1-positive de novo and myeloid blast crisis of CML, as the first manifestation of disease, based on clinical and molecular aspects are discussed.

  8. Una técnica para obtener la fase icosahédrica en peliculas delgadas multicapas de AICr

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    D. Chaverri

    2016-03-01

    Full Text Available Se describe el procedimiento empleado para producir películas delgadas de multicapas de AlCr con fase icosahédrica utilizando un sistema de alto vacío con cañón de electrones. Las muestras con fase icosahédrica experimentan reconocimiento in situ al condensar las capas sobre sustratos calientes (aproximadamente360°C. Para identificarla fase icosahédrica se utiliza microscopía electrónica de transmisión en el modo de difracción. Se comparan las muestras con fase con otras formadas simultáneamente sobre sustratos a aproximadamente 100°C.

  9. Uso de la antibioticoterapia perioperatoria en la apendicitis aguda: Use of perioperative antibiotic therapy Acute appendicitis:

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    Gimel Sosa Martín

    2009-09-01

    Full Text Available INTRODUCCIÓN. La apendicitis aguda es la afección que más frecuentemente requiere intervención quirúrgica de urgencia. El uso de profilaxis antimicrobiana disminuye la incidencia de sepsis de la herida quirúrgica y mejora la relación riesgo-beneficio y costo-beneficio de la operación. El presente estudio buscó diseñar e implantar un protocolo terapéutico para el uso de antimicrobianos, según estadio de la apendicitis aguda, para uso en centros de atención secundaria. MÉTODOS. Se realizó un estudio prospectivo de indicación-prescripción con elementos de consecuencias prácticas y un grupo de intervención. Se seleccionaron de manera aleatoria 215 pacientes con diagnóstico de apendicitis aguda, atendidos entre diciembre del 2002 y diciembre del 2006. Se establecieron dos grupos, uno de control y uno experimental. Se instauró un protocolo de profilaxis aplicado al grupo experimental, basado en textos de referencia y adecuado al contexto socioeconómico cubano. RESULTADOS. Se aplicó el protocolo de profilaxis a 105 pacientes. La incidencia de sepsis fue del 8,5 %, significativamente menor a la del grupo control (24,5 %. El costo fue igualmente menor en el grupo experimental. CONCLUSIONES. El uso racional de la terapéutica antimicrobiana para la profilaxis de la infección de la herida quirúrgica mejora la relación riesgo-beneficio y costo-beneficio del procedimiento quirúrgico y la calidad de la atención médica.INTRODUCTION: Acute appendicitis if the affection that more frequent requires of an emergence surgical intervention. Use of antimicrobial prophylaxis decreases sepsis incidence of surgical wound, and to improve the risk-benefit and the cost-benefit relation of surgery. Present study tried to design and to creates a therapeutical protocol for use of antimicrobials, according to acute appendicitis stage to use in secondary care centers. METHODS: We made a prospective study of prescription-indication with the elements

  10. Nuevo enfoque de la interpretación del dolor en una pulpitis aguda

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    Andrés O Pérez Ruiz

    2000-04-01

    Full Text Available El dolor es probablemente el principal motivo de consulta en las urgencias estomatológicas y es precisamente el dolor de la pulpitis aguda el que comentamos en este trabajo. El dolor pulpar en sí mismo es similar al dolor que resulta por inflamación de los órganos viscerales y, por lo tanto, podrían ser inadecuados los intentos de explicarlos por comparación con los nociceptores de estructuras somáticas. Se propone analizar el comportamiento del dolor como consecuencia de una pulpitis aguda, con un nuevo enfoque, asimilándolo como el dolor proveniente de estructuras viscerales con manifestaciones dolorosas alejadas del sitio o zona dañada y en el propio diente en que el tejido ha sido injuriado y evoluciona rápidamente hacia la necrosis. Establecemos una analogía entre el dolor visceral como el generado de la pulpa y el del tipo somático profundo como el correspondiente a la afectación periapical por rápida evolución de la inflamación hacia la necrosis.Pain is probably the chief complaint in dental emergencies and this paper deals precisely with the pain caused by acute pulpitis. The pulpar pain itself is similar to the one resulting from inflammation of the visceral organs and, therefore, the attempts to explain these pains by comparing them with the nociceptors of somatic structures may be inappropiate. It is our objective to analyze the behaviour of pain caused by acute pulpitis with a new approach, assimilating it as the pain from visceral structures with painful manifestations far from the damaged site or zone and it is the own tooth whose tissue has been affected and evolves rapidly to necrosis.We establish an analogy between the visceral pain as the one generated by the pulpa and that of deep somatic type as the corresponding to the periapical affection by the fast evolution of inflammation to necrosis.

  11. Prevención de las infecciones respiratorias agudas: Presente y futuro

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    Roberto Razón Behar

    2003-12-01

    Full Text Available Las infecciones respiratorias agudas (IRA, son las causas más frecuentes de morbilidad en el mundo y de elevada mortalidad particularmente en los países en desarrollo. Los virus son los agentes etiológicos más frecuentes. Los virus influenza a y b, y el virus sincitial respiratorio (VSR son los más importantes por la severidad de la enfermedad y por la alta transmisibilidad. Las bacterias, principalmente el Streptococcus pneumoniae (neumococo, y el Haemophilus influenzae tipo B (Hib, son las causas más frecuentes de neumonías adquiridas en la comunidad. Las estrategias generales en la prevención y en el tratamiento se basan en: evaluar sistemáticamente los conocimientos existentes acerca de las IRA, divulgarlos y aplicarlos, desarrollar una guía nacional para las indicaciones de los antibióticos, aplicar las vacunas existentes: DPT, triple viral (SRP, anti-Hi, incrementar la inmunización contra el neumococo y los virus influenza, particularmente en grupos de riesgo y desarrollar y evaluar nuevas vacunas contra el VSR, Haemophilus influenzae no serotipificables, Bordetella pertussis y otros agentes infecciosos que afectan el aparato respiratorio. Se realiza una revisión de nuevos agentes y drogas antivirales, así como del desarrollo presente y futuro de las inmunizaciones contra los principales virus y bacterias, que causan infecciones respiratorias agudas.Acute respiratory infections (ARI are the most frequent cause of morbidity and of the high mortality in the world, particularly in the developing countries. The viruses are the most common etiological agents.The influenza a and b viruses and the syncytial respiratory virus (SRV are the most important due to the severity of the disease and to their high transmissibility. The bacteria, mainly Streptococcus pneumoniae (Pneumococcus, and Haemophilus influenzae type B (Hib, are the most frequent cause of pneumonias acquired in the community. The general strategies in the prevention and

  12. Efeitos hemodinâmicos da sobrecarga ventricular direita aguda experimental

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    Flávio Brito Filho

    2011-04-01

    Full Text Available FUNDAMENTO: A sobrecarga ventricular direita aguda está associada a situações clínicas de elevada morbimortalidade, tais como: ressecções pulmonares extensas, tromboembolismo pulmonar, transplante pulmonar e edema pulmonar das altitudes. Alguns pontos de sua fisiopatologia permanecem obscuros. OBJETIVO: Avaliar os efeitos hemodinâmicos da sobrecarga ventricular direita aguda experimental em suínos. MÉTODOS: A sobrecarga ventricular direita foi induzida pela oclusão das artérias pulmonares através de ligaduras. Vinte porcos foram utilizados no estudo, sendo alocados em 04 grupos: um controle, não submetido à oclusão vascular pulmonar, e três de sobrecarga ventricular direita submetidos à oclusão das seguintes artérias pulmonares: SVD1 (artéria pulmonar esquerda; SVD2 (artéria pulmonar esquerda e do lobo inferior direito e SVD3 (artéria pulmonar esquerda, do lobo inferior direito e do lobo mediastinal, obstruindo a vasculatura pulmonar em 42, 76 e 82,0% respectivamente. Variáveis de hemodinâmica foram medidas a cada 15 minutos durante a uma hora do estudo. Na análise estatística, foram utilizados ajustes de modelos lineares mistos com estrutura de variâncias e covariâncias. RESULTADOS: Nas comparações intergrupais, houve aumento significativo da frequência cardíaca (p = 0,004, pressão arterial pulmonar média (p = 0,001 e pressão capilar pulmonar (p < 0,0001. Houve redução significativa da pressão arterial média (p = 0,01 e do índice sistólico (p = 0,002. Não houve diferença significativa no índice cardíaco (p = 0,94. CONCLUSÃO: Apesar da intensa sobrecarga ventricular direita promovida pela obstrução de 82,0% da vasculatura pulmonar e pelo aumento significativo da pressão arterial pulmonar não houve disfunção cardiovascular severa e/ou choque circulatório no período estudado.

  13. Micronutrientes: una opción en el tratamiento de las enfermedades diarreicas agudas

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    Carlos Coronel Carbajal

    2000-12-01

    Full Text Available Se realizó un estudio longitudinal y prospectivo a 126 pacientes que ingresaron al Servicio de Diarreas Agudas del Hospital General Docente "Armando Enrique Cardoso", en el período comprendido entre junio de 1998 y enero de 1999. A 71 pacientes se les ofrecieron microelementos (vitamina A, sulfato de zinc y fumarato ferroso con el objetivo de conocer los beneficios de los microelementos en la enfermedad diarreica aguda. Al concluir el estudio se pudo comprobar que el grupo de pacientes suplementados tuvo una estadía más corta y la duración del episodio fue menor. Además se halló que en estos pacientes el número de deposiciones es menor, así como la afectación nutricional. También se comprobó cómo la recuperación nutricional es mucho más rápida, así como la recuperación del apetito. Se pudo mostrar cómo la consistencia de las deposiciones al tercer día de tratamiento, en el grupo que recibió micronutrientes, mejoró.A longitudinal and prospective study was conducted among 126 patients that were admitted in the Service of Acute Diarrheas of "Armando Enrique Cardoso" General Teaching Hospital between June, 1998, and January, 1999. 71 patients were administered microelements (vitamin A, zinc sulfate and ferrous fumarate in order to know their benefits in the acute diarrheal disease. On concluding the study, it was proved that the length of stay and the episode were shorter in the group of supplemented patients. It was also observed that the number of defecations as well as the nutritional affectation were lower in these patients and that the nutritional recovery and the recuperation of appetite were faster. The consistency of the defecations improved on the third day of treatment in the group that received micronutrients.

  14. Respuesta del sistema antioxidante en varones sanos, frente a hiperglicemia aguda inducida

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    Raquel Oré

    2009-09-01

    Full Text Available Objetivo: determinar la respuesta del sistema antioxidante en varones sanos, frente a la hiperglicemia aguda inducida. Diseño: estudio prospectivo, descriptivo, longitudinal, experimental. Lugar: Instituto Nacional de Biología Andina, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. Material biológico: Sangre y suero de sujetos aparentemente sanos. Intervenciones: A 13 sujetos adultos clínicamente sanos, entre 20 y 41años, después de 10 horas de ayuno, se administró glucosa vía endovenosa, mediante el método de clamp hiperglicémico, a 125 mg/dL por encima del valor basal, durante 120 minutos. Se realizó mediciones de la glicemia a 0, 5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110 y 120 minutos. Se tomó la muestra sanguínea con anticoagulante EDTA y otra de sangre total, para obtención de suero, para las pruebas bioquímicas a los 0, 60 y 120 minutos. Principales medidas de resultados: Modificaciones de la glicemia y lipoperoxidación en suero, glutatión y actividad superóxido dismutasa en glóbulos rojos lisados e índices de estrés oxidativo. Resultados: El nivel de glucosa durante el clamp hiperglicémico, luego de alcanzar el ‘equilibrio’, fue 197±17,58 mg/dL. La lipoperoxidación aumentó de 2,54 + 0,51 a 2,90 + 0,58 umol/L, de 0 a 60 minutos, y a 2,66 + 0,55 umol/L a los 120 minutos. El glutatión se redujo en 8,10% a la hora, aumentando 7,08% a los 120 minutos. La actividad superóxido dismutasa se elevó 0,54% a los 60 minutos y 5,66% a los 120 minutos, sobre el basal. Los índices de valoración del estrés oxidativo tuvieron correlación r Pearson positiva, en nivel alto a muy alto. Conclusiones: la hiperglicemia aguda inducida hasta 2 horas elevó el estrés oxidativo, promoviendo generación de defensa antioxidante, con síntesis de glutatión reducido de novo y mayor actividad de la superóxido dismutasa.

  15. Caracterización epidemiológica de la descompensación aguda del asma bronquial

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    Yanin Arteaga Prado

    2013-08-01

    Full Text Available Introducción: el asma bronquial tiene una compleja fisiopatología que involucra la presencia en el paciente de factores genéticos de atopia, mecanismos inmunológicos disfuncionales. Objetivo: caracterizar la asociación de diversos aspectos epidemiológicos con la aparición de descompensaciones agudas del asma bronquial. Material y método: se realizó un estudio descriptivo y transversal a 118 pacientes del área de dos consultorios médicos del Policlínico Universitario "Hermanos Cruz" de la Ciudad de Pinar del Río durante el primer trimestre del 2012. Se comparó el grupo de pacientes que presentaron descompensaciones de la enfermedad con el grupo de pacientes que no se descompensó. Se aplicó un cuestionario para explorar las variables de interés. Para verificar la asociación entre variables se utilizó el estadígrafo ji cuadrado para un valor de significación estadística á=0.05. Resultados: las descompensaciones agudas fueron casi dos veces más frecuentes en el sexo femenino. De manera muy significativa (Z=3,26 p<0,01 una tercera parte de los asmáticos de su enfermedad; las amas de casa y los estudiantes fueron los más afectados. Solo el 38,1 % de los asmáticos tuvo un adecuado seguimiento por un especialista (clínico, pediatra, alergólogo o inmunólogo y de estos solo el 11,1 % presentaron descompensaciones agudas, en tanto se descompensó un 39,7 % de los que no tienen seguimiento especializado. Conclusiones: la degradación de las condiciones de la vivienda favoreció la aparición de descompensaciones agudas del asma. En tres cuartas partes de las casas había animales domésticos, existiendo una fuerte asociación entre esta condición y la aparición de descompensaciones agudas del paciente asmático.

  16. Incidencia y factores de riesgo para adquirir diarrea aguda en una comunidad rural de la selva peruana

    Directory of Open Access Journals (Sweden)

    César Henríquez Camacho

    2002-04-01

    Full Text Available Objetivo: Determinar la incidencia y factores de riesgo para adquirir diarrea aguda en una comunidad rural localizada en la selva del departamento de San Martín, Perú. Material y métodos: Una cohorte de 119 personas fue seleccionada al azar entre la población de 446 habitantes y seguida diariamente por un mes entre enero y febrero de 1999, buscando casos de diarrea aguda, definida como tres ó más cámaras de deposiciones al día por no más de 3 días. Un estudio caso control pareado fue diseñado para determinar los factores de riesgo para adquirir diarrea. Resultados: Fueron observados 18 casos de diarrea aguda; la incidencia fue 15.1 casos por 100 personas-mes (IC 95%: 9.45-23.12. La edad media de los casos fue de 10.7 años (rango: 1-34 años y 66% de los casos fueron niños menores de 10 años de edad. Los factores de riesgo para adquirir diarrea fueron: consumo de alimentos crudos, RR: 2.2 (IC 95%: 1.12-4.33, consumo de alimentos no lavados, RR: 4.47 (IC 95%: 1.56-12.82, falta de lavado de manos antes de alimentarse, RR: 9.61 (95% IC: 1.44-64.16, consumo de agua no hervida, RR: 4.52 (IC 95%: 1.23-16.65 y alimentación fuera de casa, RR: 2.2 (IC 95%: 1.51-3.20. La diferencia en el número promedio (DE de personas que vivían por casa entre casos y controles fue de 4.38 (1.03 vs. 3.22 (0.54, p=0.0003, respectivamente. No hubo diferencia en el tiempo de residencia en la comunidad entre casos y controles, media de 5.61 ( 5.04 años vs. 8.83 (9.79, p=0.5747. Conclusiones: Diarrea aguda es un problema de salud pública en la selva de San Martín. Hacinamiento, carencia de saneamiento y pobres prácticas higiénicas son los responsables para adquirir diarrea aguda en esta comunidad de bajo nivel socioeconómico. Campañas educativas y mejora en las condiciones sanitarias son claramente necesarias para superar este problema.

  17. The cathepsin B inhibitor z-FA-CMK induces cell death in leukemic T cells via oxidative stress.

    Science.gov (United States)

    Liow, K Y; Chow, Sek C

    2018-01-01

    The cathepsin B inhibitor benzyloxycarbonyl-phenylalanine-alanine-chloromethyl ketone (z-FA-CMK) was recently found to induce apoptosis at low concentrations in Jurkat T cells, while at higher concentrations, the cells die of necrosis. In the present study, we showed that z-FA-CMK readily depletes intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) generation. The toxicity of z-FA-CMK in Jurkat T cells was completely abrogated by N-acetylcysteine (NAC), suggesting that the toxicity mediated by z-FA-CMK is due to oxidative stress. We found that L-buthionine sulfoximine (BSO) which depletes intracellular GSH through the inhibition of GSH biosynthesis in Jurkat T cells did not promote ROS increase or induce cell death. However, NAC was still able to block z-FA-CMK toxicity in Jurkat T cells in the presence of BSO, indicating that the protective effect of NAC does not involve GSH biosynthesis. This is further corroborated by the protective effect of the non-metabolically active D-cysteine on z-FA-CMK toxicity. Furthermore, in BSO-treated cells, z-FA-CMK-induced ROS increased which remains unchanged, suggesting that the depletion of GSH and increase in ROS generation mediated by z-FA-CMK may be two separate events. Collectively, our results demonstrated that z-FA-CMK toxicity is mediated by oxidative stress through the increase in ROS generation.

  18. HEAT TRANSFER EVALUATION OF HFC-236FA IN CONDENSATION AND EVAPORATION

    Science.gov (United States)

    The report gives results of an evaluation of the shell-side heat transfer performance of hydrofluorocarbon (HFC)-236fa, which is considered to be a potential substitute for chlorofluorocarbon (CFC)-114 in Navy shipboard chillers, for both conventional finned [1024- and 1575-fpm (...

  19. The Arabic Hyperbolic Pattern "Fa??al" in Two Recent Translations of the Qur'an

    Science.gov (United States)

    El-Zawawy, Amr M.

    2014-01-01

    The present study addresses the problem of rendering the ?? ?? 'fa??al' hyperbolic pattern into English in two recent translations of the Qur'an. Due to the variety of Qur'an translations and the large amount of hyperbolic forms of Arabic verbs recorded in the Qur'an, only two translations of the Qur'an are consulted and analyzed: these two…

  20. Consumption of fa cai Nostoc soup: a potential for BMAA exposure from Nostoc cyanobacteria in China?

    Science.gov (United States)

    Roney, Britton R; Renhui, Li; Banack, Sandra Anne; Murch, Susan; Honegger, Rosmarie; Cox, Paul Alan

    2009-01-01

    Grown in arid regions of western China the cyanobacterium Nostoc flagelliforme--called fa cai in Mandarin and fat choy in Cantonese--is wild-harvested and used to make soup consumed during New Year's celebrations. High prices, up to $125 USD/kg, led to overharvesting in Inner Mongolia, Ningxia, Gansu, Qinghai, and Xinjiang. Degradation of arid ecosystems, desertification, and conflicts between Nostoc harvesters and Mongol herdsmen concerned the Chinese environmental authorities, leading to a government ban of Nostoc commerce. This ban stimulated increased marketing of a substitute made from starch. We analysed samples purchased throughout China as well as in Chinese markets in the United States and the United Kingdom. Some were counterfeits consisting of dyed starch noodles. A few samples from California contained Nostoc flagelliforme but were adulterated with starch noodles. Other samples, including those from the United Kingdom, consisted of pure Nostoc flagelliforme. A recent survey of markets in Cheng Du showed no real Nostoc flagelliforme to be marketed. Real and artificial fa cai differ in the presence of beta-N-methylamino-L-alanine (BMAA). Given its status as a high-priced luxury food, the government ban on collection and marketing, and the replacement of real fa cai with starch substitutes consumed only on special occasions, it is anticipated that dietary exposure to BMAA from fa cai will be reduced in the future in China.

  1. ECCS analysis of B and W's 177-FA lowered-loop NSS

    International Nuclear Information System (INIS)

    Jones, R.C.; Biller, J.R.; Dunn, B.M.

    1975-06-01

    The effectiveness for the ECCS for B and W's 177-FA Lowered-Loop NSS is shown to meet the five criteria of 10 CFR 50.46. A spectrum analysis is performed and the worst case is used to establish allowable linear heat rates as a function of elevation in the core. (U.S.)

  2. Adaptive Façade: Variant-Finding using Shape Grammar

    Science.gov (United States)

    Tomasowa, Riva; Utama Sjarifudin, Firza

    2017-12-01

    Modular façade construction has never been better since the birth of computer-aided manufacturing which bridges the modeling phase into the manufacturing phase for escalating the mass production. This comes to a result that the identity of a product or a building façade will commonly generate in the same way that the initial design was intended to. Rectifying the early model will then greatly impact the process later. The aim of this paper is to propose a way to solve these two challenges, without risking the manufacturing process, but more to explore the potential designs. Shape grammar is used to conceive more designs in the early stage, derived from the initial product - the modular adaptive façade system. The derivations are then tested through simulation to state the efficacy of the models. We find that the workflow somehow contributes to the better design and engineering process as well as the solution allows diversification in the façade expressions.

  3. Obesity is accompanied by disturbances in peripheral glucocorticoid metabolism and changes in FA recycling

    DEFF Research Database (Denmark)

    Simonyte, Kotryna; Rask, Eva; Näslund, Ingmar

    2009-01-01

    and activity of 11betaHSD1 as well as the expression of phosphoenolpyruvate carboxykinase (PEPCK), sterol regulatory element binding protein (SREBP), and fatty acid synthase (FAS) in adipose and liver and investigated putative associations between 11betaHSD1 and energy metabolism genes. A total of 33 obese...... acid (FA) recycling in adipose tissue (AT)....

  4. Dynamic behavior of reactive aluminum nanoparticle-fluorinated acrylic (AlFA) polymer composites

    Science.gov (United States)

    Crouse, Christopher A.; White, Brad; Spowart, Jonathan E.

    2011-06-01

    The dynamic behavior of aluminum nanoparticle-fluorinated acrylic (AlFA) composite materials has been explored under high strain rates. Cylindrical pellets of the AlFA composite materials were mounted onto copper sabots and impacted against a rigid anvil at velocities between 100 and 400 m/s utilizing a Taylor gas gun apparatus to achieve strain rates on the order of 104 /s. A framing camera was used to record the compaction and reaction events that occurred upon contact of the pellet with the anvil. Under both open air and vacuum environments the AlFA composites demonstrated high reactivity suggesting that the particles are primarily reacting with the fluorinated matrix. We hypothesize, based upon the compaction history of these materials, that reaction is initiated when the oxide shells on the aluminum nanoparticles are broken due an interparticle contact deformation process. We have investigated this hypothesis through altering the particle loading in the AlFA composites as well as impact velocities. This data and the corresponding trends will be presented in detail.

  5. Data of evolutionary structure change: 1B0FA-2FOCA [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1B0FA-2FOCA 1B0F 2FOC A A IVGGRRARPHAWPFMVSLQLA----GGHFCGATLIAPNF...>2FOC A 2FOCA SLQYRSGSSWAHTC ...tryChain> 2FOC A 2FOCA PLHCLVNGQY...ine> 2FOC A 2FOCA...in>A 2FOCA HCVDR--ELTFR GG

  6. The scope of inducing natural air supply via the façade

    NARCIS (Netherlands)

    van den Engel, P.J.W.; Kurvers, S.R.

    2017-01-01

    An overview is given of recent developments in the use of a system of inducing natural air supply via the façade in the Netherlands. This is followed by a review of the results of measurements from climate chamber experiments of its inducing ventilation performance and detailed insights gained

  7. Methodology for Thermal Behaviour Assessment of Homogeneous Façades in Heritage Buildings

    Directory of Open Access Journals (Sweden)

    Enrique Gil

    2017-01-01

    Full Text Available It is fundamental to study the thermal behaviour in all architectural constructions throughout their useful life, in order to detect early deterioration ensuring durability, in addition to achieving and maintaining the interior comfort with the minimum energy consumption possible. This research has developed a methodology to assess the thermal behaviour of façades in heritage buildings. This paper presents methodology validation and verification (V & V through a laboratory experiment. Guidelines and conclusions are extracted with the employment of three techniques in this experiment (thermal sensors, thermal imaging camera, and 3D thermal simulation in finite element software. A small portion of a homogeneous façade has been reproduced with indoor and outdoor thermal conditions. A closed chamber was constructed with wood panels and thermal insulation, leaving only one face exposed to the outside conditions, with a heat source inside the chamber that induces a temperature gradient in the wall. With this methodology, it is possible to better understand the thermal behaviour of the façade and to detect possible damage with the calibration and comparison of the results obtained by the experimental and theoretical techniques. This methodology can be extrapolated to the analysis of the thermal behaviour of façades in heritage buildings, usually made up of homogeneous material.

  8. F-15A Versus F/A-22 Initial Operational Capability. A Case for Transformation

    National Research Council Canada - National Science Library

    Mott V, William H

    2005-01-01

    The F/A-22 Raptor is a new weapons system replacing- the F-15C Eagle. Its operational debut in 2005 comes at a time of constrained budgets, a changing global threat environment, and the ongoing global war on terrorism (GWOT...

  9. OTITIS MEDIA AGUDA. DIAGNÓSTICO Y MANEJO PRÁCTICO

    Directory of Open Access Journals (Sweden)

    Dr. Francisco J. Krause

    2016-11-01

    Full Text Available La otitis media aguda es una patología infecciosa del oído medio muy frecuente. El diagnóstico es clínico, por lo que es fundamental un acucioso examen físico y una neumootoscopía para evaluar la movilidad timpánica. Hay dos tendencias respecto al manejo, tratamiento antibiótico inmediato u observación estricta (dependiendo de las características del paciente y del cuadro clínico. Los gérmenes más frecuentes son los virus, Neumococo, Haemophilus influenza y Moraxella catarrhalis. La prevalencia de cada uno de ellos varía según región geográfica y según la presencia de vacunación. La resistencia a antibióticos ha ido en aumento en estos años, pero aún puede considerarse sensible a amoxicilina por lo que se recomienda su uso como primera línea. En el caso de fracaso a tratamiento pueden utilizarse asociaciones con B-lactámicos y/o cefalosporinas, dejando en forma excepcional clindamicina o quinolonas. Aquellos niños con OMA recurrente requerirán evaluación por especialidad para mayor estudio y tratamiento.

  10. Insuficiência renal aguda em paciente tratada com ATRA e anfotericina B: relato de caso

    Directory of Open Access Journals (Sweden)

    Gelcimar Moresco

    2011-06-01

    Full Text Available O presente relato apresenta o caso clínico de uma paciente com leucemia promie-locítica aguda tratada com ácido todo-transretinoico (ATRA, que apresentou suspeita de síndrome do ácido transreti-noico (síndrome de ATRA. Com a ocor-rência de leucopenia febril inespecífica, foram associados ao tratamento antimi-crobianos e antifúngicos. A diminuição da função renal, observada inicialmente, contribuiu para a suspeita de síndrome de ATRA, que foi agravada pelos antifúngi-cos. Assim, o uso de ATRA foi suspenso, mas somente 8 dias depois foi caracteriza-da pneumonia e descartada a hipótese de síndrome de ATRA. Nesse contexto, foi discutida a nefrotoxicidade do ATRA e a potencialização desse efeito adverso pelo uso de antifúngicos nefrotóxicos, em par-ticular da anfotericina B, assim como a im-portância do diagnóstico diferencial entre síndrome de ATRA e doença infecciosa.

  11. Subtipos moleculares de PML/RARα en pacientes con leucemia promielocítica aguda

    Directory of Open Access Journals (Sweden)

    María del Carmen Castro-Mujica

    2013-03-01

    Full Text Available El objetivo fue describir la frecuencia de los subtipos moleculares de PML/RARα en pacientes con leucemia promielocítica aguda (LPA y su distribución según grupo de riesgo de recaída y citomorfología. Se realizó una serie de casos que incluyó a cincuenta pacientes registrados en el Instituto Nacional de Enfermedades Neoplásicas (INEN, durante el periodo 2010-2012, con diagnóstico molecular de LPA PML/RARα y subtipos bcr1, bcr2 y bcr3 por reacción en cadena de la polimerasa con transcriptasa reversa (RT-PCR. El subtipo bcr1 fue el más frecuente (62%. Los pacientes con riesgo de recaída intermedio y morfología hipergranular fueron, en su mayoría, bcr1 (70% y todos los que poseían riesgo de recaída alto y morfología hipogranular fueron bcr3. Se concluye que en la población estudiada hay un predomino del subtipo bcr1 y que existen diferencias en la distribución de los subtipos bcr1 y bcr3 según el grupo de riesgo de recaída y citomorfología

  12. Leucemias agudas en ancianos de la provincia de Santiago de Cuba

    Directory of Open Access Journals (Sweden)

    Lidia Clara Suárez Beyríes

    2015-04-01

    Full Text Available Se realizó un estudio descriptivo y retrospectivo de 64 pacientes mayores de 60 años con leucemia aguda, atendidos en el Servicio de Hematología del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, durante el quinquenio 2006-2011, para determinar las principales características clínicas y hematológicas en el momento del diagnóstico, así como la supervivencia global de los afectados, aunque los tratamientos administrados no tenían criterio curativo. La edad promedio de los ancianos fue de 70 años, en un rango etario de 60 a 90; en tanto, la variedad no linfoblástica representó 98,4 %, y todos los pacientes presentaron anemia y trombocitopenia como alteraciones hematológicas, con incremento en los requerimientos transfusionales. De igual forma, la presencia de blastos en la sangre periférica se demostró en 50 % y la hiperleucocitosis en 59,4 %, mientras las principales causas de muerte estuvieron relacionadas con la hemorragia cerebral y la progresión de la enfermedad con la infiltración multiorgánica, lo cual condujo a una supervivencia muy corta de los integrantes de la serie

  13. Consumo alimentar e estresse em pacientes com síndrome coronariana aguda

    Directory of Open Access Journals (Sweden)

    Evelise Helena Fadini Reis Brunori

    2015-10-01

    Full Text Available RESUMOObjetivo:Avaliar se o consumo alimentar de pacientes com síndrome coronariana aguda (SCA segue as recomendações nacionais e internacionais e se existe relação com níveis de estresseMétodo:Estudo transversal com 150 pacientes com SCA que foram entrevistados utilizando-se os Questionários de Frequência Alimentar e Escala de Estresse Percebido-10.Resultados:Consumo diário acima das recomendações: colesterol (92%, fi bras (42,7% e proteínas (68%; consumo abaixo das recomendações: potássio (88% e carboidratos (68,7%; consumo conforme recomendações: sódio (53,3% e lípides (53,3%. A maioria (54% com consumo alimentar inadequado era estressada ou altamente estressada. Houve associação estatisticamente signifi cante entre menor nível de estresse e maior consumo de fibras.Conclusão:Em pacientes com SCA, o consumo alimentar esteve fora do recomendado pelas diretrizes e o menor consumo de fibras ocorre concomitantemente com maior estresse. Esforços educativos podem instrumentalizar os pacientes na adequação do consumo alimentar e no controle do estresse.

  14. Toxicidad aguda de las hojas de Xanthium spinosum en ratones BALB/C

    Directory of Open Access Journals (Sweden)

    Arturo Silvero-Isidre

    2016-01-01

    Full Text Available Las hojas de la planta Xanthium spinosum se utilizan culturalmente en Paraguay por sus propiedades medicinales. Se evaluó la toxicidad aguda del extracto de hojas maduras; para el estudio se seleccionaron 35 ratones BALB/C machos que fueron distribuidos en 7 grupos, 6 de ensayo y 1 de control. El extracto fue preparado en concentraciones de 6 y 9% (g/dL; se administró la solución 6% a tres grupos y la solución 9% a los otros tres grupos, con dosis entre 200 y 1000 mg/kg. Al final de 14 días de observación, se extrajeron muestras de sangre para estudios laboratoriales de urea y transaminasas, además de órganos para estudios anatomopatológicos. Se determinaron aumentos en los niveles de GOT y urea en comparación al grupo control. Se concluye que el consumo del extracto de hojas maduras de Xanthium spinosum puede causar daño hepático.

  15. Actuación de enfermería en la leucemia mieloide aguda.

    Directory of Open Access Journals (Sweden)

    Melchor Pino, Pilar

    2012-08-01

    Full Text Available La leucemia mieloide aguda (LMA es una proliferación neoplásica de células inmaduras de estirpe mieloide que se produce por una alteración en el crecimiento y diferenciación de las células hematopoyéticas.En este trabajo se presenta un caso clínico sobre un paciente de 37 años diagnosticado de LMA. Se hace una valoración de las necesidades básicas siguiendo el modelo de Virginia Henderson al ingreso del paciente, mediante una entrevista dirigida y la obtención de datos mediante la observación.El objetivo general es elaborar un plan individualizado de cuidados a dicho paciente, mediante la aplicación del Proceso Enfermero y la utilización de la taxonomía NANDA-NOC-NIC que nos permitirá aplicar unos cuidados de calidad a este paciente.Cuando el paciente abandone el hospital, la enfermera le entregará un informe de alta, que asegurará la continuidad de sus cuidados.

  16. Reacciones adversas e interacciones medicamentosas en el tratamiento de las enfermedades respiratorias agudas

    Directory of Open Access Journals (Sweden)

    Oneyda Clapé Laffita

    2000-12-01

    Full Text Available Como continuación de los estudios de farmacovigilancia en la Unidad de Cuidados Intensivos e Intermedios del Hospital Provincial Docente Clinicoquirúrgico "Saturnino Lora", se evaluaron las reacciones adversas e interacciones medicamentosas detectadas en el tratamiento de las enfermedades respiratorias agudas, para lo cual se aplicó el método de vigilancia intensiva del paciente hospitalizado, a fin de validar los datos obtenidos farmacológica y estadísticamente. Se encontraron 96 reacciones adversas y 47 interacciones medicamentosas, valores estos que fueron relacionados con aspectos clínicos y demográficos. Los posibles riesgos quedaron atenuados por las medidas propuestas en cada plan terapéutico y la orientación farmacológica al enfermo.As part of the pharmacovigilance studies conducted at the Intensive and Intermediate Care Unit of the "Saturnino Lora" Provincial Clinical and Surgical Teaching Hospital, the adverse reactions and drug interactions detected in the treatment of acute respiratory diseases were evaluated. The method of intensive surveillance of the hospitalized patient was used to validate the data obtained from the pharmacological and statistical point of view. 96 adverse reactions and 47 drug interactions were found. These values were related to clinical and demographic aspects. The possible risks were attenuated by the measures proposed in each therapeutic plan and the pharmacological advice given to the patient.

  17. A case report and literature review of Fanconi Anemia (FA) diagnosed by genetic testing.

    Science.gov (United States)

    Solomon, Ponnumony John; Margaret, Priya; Rajendran, Ramya; Ramalingam, Revathy; Menezes, Godfred A; Shirley, Alph S; Lee, Seung Jun; Seong, Moon-Woo; Park, Sung Sup; Seol, Dodam; Seo, Soo Hyun

    2015-05-08

    Fanconi anemia (FA) is a genetically heterogeneous rare autosomal recessive disorder characterized by congenital malformations, hematological problems and predisposition to malignancies. The genes that have been found to be mutated in FA patients are called FANC. To date 16 distinct FANC genes have been reported. Among these, mutations in FANCA are the most frequent among FA patients worldwide which account for 60- 65%. In this study, a nine years old male child was brought to our hospital one year ago for opinion and advice. He was the third child born to consanguineous parents. The mutation analyses were performed for proband, parents, elder sibling and the relatives [maternal aunt and maternal aunt's son (cousin)]. Molecular genetic testing [targeted next-generation sequencing (MiSeq, Illumina method)] was performed by mutation analysis in 15 genes involved. Entire coding exons and their flanking regions of the genes were analysed. Sanger sequencing [(ABI 3730 analyzer by Applied Biosystems)] was performed using primers specific for 43 coding exons of the FANCA gene. A novel splice site mutation, c.3066 + 1G > T, (IVS31 + 1G > T), homozygote was detected by sequencing in the patient. The above sequence variant was identified in heterozygous state in his parents. Further, the above sequence variant was not identified in other family members (elder sibling, maternal aunt and cousin). It is concluded that genetic study should be done if possible in all the cases of suspected FA, including siblings, parents and close blood relatives. It will help us to plan appropriate treatment and also to select suitable donor for hematopoietic stem cell transplantation and to plan for genetic counseling. In addition to the case report, the main focus of this manuscript was to review literature on role of FANCA gene in FA since large number of FANCA mutations and polymorphisms have been identified.

  18. Slicing Method for curved façade and window extraction from point clouds

    Science.gov (United States)

    Iman Zolanvari, S. M.; Laefer, Debra F.

    2016-09-01

    Laser scanning technology is a fast and reliable method to survey structures. However, the automatic conversion of such data into solid models for computation remains a major challenge, especially where non-rectilinear features are present. Since, openings and the overall dimensions of the buildings are the most critical elements in computational models for structural analysis, this article introduces the Slicing Method as a new, computationally-efficient method for extracting overall façade and window boundary points for reconstructing a façade into a geometry compatible for computational modelling. After finding a principal plane, the technique slices a façade into limited portions, with each slice representing a unique, imaginary section passing through a building. This is done along a façade's principal axes to segregate window and door openings from structural portions of the load-bearing masonry walls. The method detects each opening area's boundaries, as well as the overall boundary of the façade, in part, by using a one-dimensional projection to accelerate processing. Slices were optimised as 14.3 slices per vertical metre of building and 25 slices per horizontal metre of building, irrespective of building configuration or complexity. The proposed procedure was validated by its application to three highly decorative, historic brick buildings. Accuracy in excess of 93% was achieved with no manual intervention on highly complex buildings and nearly 100% on simple ones. Furthermore, computational times were less than 3 sec for data sets up to 2.6 million points, while similar existing approaches required more than 16 hr for such datasets.

  19. A salinomicina para o controle da eimeriose de caprinos leiteiros nas fases de cria e recria

    Directory of Open Access Journals (Sweden)

    Vieira Luiz da Silva

    2004-01-01

    Full Text Available A salinomicina foi avaliada no controle da eimeriose caprina em 27 cabritos mestiços distribuídos aleatoriamente em três tratamentos num delineamento inteiramente casualizado: T0, não medicados (grupo controle; T1 e T2, medicados com doses de 1 e 2mg de salinomicina/kg de peso vivo/dia, respectivamente. Na fase de cria, não houve diferença estatística (P>0,005 no ganho médio de peso (GP entre os três tratamentos. Na fase de recria, o grupo T0 apresentou GP significativamente inferior (P0,005. O número médio de oocistos por grama de fezes (OOPG do grupo T0, nas duas fases estudadas, foi significativamente maior (P0,005 entre si. O grupo T0 apresentou rendimento médio de carcaça (RC significativamente inferior (P0,005. O peso médio da massa corporal (MC do grupo T0 foi inferior (P0,005 do grupo T1; entre os grupos T1 e T2, não houve diferença significativa (P>0,005 no peso médio da massa corporal (MC. O uso da salinomicina nas doses de 1 e 2mg/kg, resultou em maior ganho de peso dos animais dos grupos T1 e T2 e, consequentemente, maior valor da margem bruta destes tratamentos. Os resultados obtidos mostraram que os T1 e T2 foram equivalentes para o controle da eimeriose caprina, uma vez que ambos os tratamentos apresentaram maior ganho de peso e oocistograma inferior ao grupo T0. Conclui-se que o tratamento com a salinomicina na dose de 1,0mg/kg é eficaz, desde que seja administrada a partir da segunda semana de vida.

  20. El retrato de fase como una herramienta de análisis del comportamiento motor

    Directory of Open Access Journals (Sweden)

    Rosa Angulo-Barroso

    2016-04-01

    Full Text Available Existe un gran número de investigaciones centradas en la adquisición y perfeccionamiento de habilidades motrices. Estas investigaciones intentan explicar cuál es la fuente y los procesos de cambio de los comportamientos motores que permiten al individuo adquirir o perfeccionar una habilidad. La ventaja de la Teoría de los Sistemas Dinámicos (TSD como marco de referencia es la inclusión de un análisis contextual en el proceso de aprendizaje. El objetivo de este artículo es dar a conocer una metodología llamada retrato de fase, la cual facilita el estudio del comportamiento motor basándose en los principios de la TSD. Datos biomecánicos tratados con una técnica de reducción adecuada constituyen una buena herramienta para describir y entender los cambios que suceden en el comportamiento motor. Los retratos de fase, mediante un gráfico (posición angular, velocidad angular, son capaces de capturar el complejo juego de fuerzas que influyen en el comportamiento motor. En este artículo, las formas de las trayectorias de los gráficos nos indicaron: (1 cómo el organismo se comporta durante la realización de las habilidades motoras analizadas mostrando sus patrones generales; (2 las singularidades poblacionales (con deficiencias y sin deficiencias o individuales; (3 los comportamientos adquiridos en el proceso de aprendizaje (novato y experto; y (4 los cambios producidos por manipulación del entorno. No obstante, los retratos de fase aunque muy útiles para resumir el comportamiento motor, no son representaciones completas del mismo y deberíamos completarlos con otras técnicas de análisis.

  1. Planeamiento del proceso constructivo del PAD I fase III en la mina Cerro Verde

    OpenAIRE

    Tomas Loayza, Mariela Irma; Tomas Loayza, Mariela Irma; Tomas Loayza, Mariela Irma

    2015-01-01

    El planeamiento constructivo del PAD 1 Fase III ha sido elaborado detalladamente teniendo en cuenta un trabajo calificado de investigación, plasmando los resultados en el cronograma de ejecución y corroborando la ejecución de la obra mediante el ciclograma. Los alcances del proyecto son los estudios de topografía, estudios geotécnicos, geológicos y diseño civil, que son dados en el capítulo 11. La topografía es el relieve que representa la zona caracterizándose por taludes con elevada p...

  2. Equilibrio de fases de sistemas compostos por oleos vegetais, acidos graxos e etanol hidratado.

    OpenAIRE

    Cintia Bernardo Gonçalves

    2004-01-01

    Resumo: Este trabalho de tese de doutoramento teve como objetivo avaliar vários aspectos do processo de extração líquido-líquido (ELL) como uma rota alternativa para a desacidificação de óleos vegetais. O conhecimento do equilíbrio de fases do sistema de interesse é essencial para o bom planejamento e desenvolvimento do processo de ELL. O presente trabalho apresenta dados de equilíbrio para sistemas compostos por óleos vegetais (milho/palma), ácidos graxos (oléico/ palmítico) e solvente (etan...

  3. Mapas conceptuales como primera fase del diseño de bases de datos

    OpenAIRE

    Gómez Gauchía, Héctor

    2005-01-01

    En nuestra asignatura de Bases de Datos los alumnos no entienden el proceso de diseño de bases de datos fácilmente. Hemos descubierto que es un problema previo a donde empieza el diseño de base de datos habitual, el problema está en la fase de formación de conceptos. Nuestra propuesta consiste en incluir, en el proceso, el uso de mapas conceptuales. Y, así, representar conocimiento declarativo a un nivel muy bajo, usando conceptos relacionados con frases de enlac...

  4. Calculos de estabilidade e divisão de fases por meio de redes neurais artificiais

    OpenAIRE

    Jones Erni Schmitz

    2006-01-01

    Resumo: A simulação de processos é um componente fundamental de uma grande variedade de atividades de Engenharia de Processos, tais como a Otimização Online, o controle em Tempo Real, a Identificação, etc. O cálculo de Equilíbrio de Fases é uma atividade fundamental em qualquer simulação de processos de separação. O elevado tempo computacional deste cálculo provocado pela sua natureza iterativa pode criar incompatibilidades entre a atividade de simulação e as aplicações em tempo real que ela ...

  5. TransiÃÃes de fase em monocristais de D-Metionina

    OpenAIRE

    Wanessa David Canedo Melo

    2012-01-01

    Nesse trabalho investigamos as propriedades vibracionais em monocristais D-Metionina, utilizando as espectroscopias Raman e Infravermelho. As medidas de espectroscopia Raman foram realizadas sob a variaÃÃo de pressÃo hidrostÃtica no intervalo de 0GPA atà 7GPa, mostraram duas transiÃÃes de fase, uma por volta 2.0GPa e outra em 2.5GPa, as quais foram detectadas no espectro Raman atravÃs das mudanÃas exibidas pelos picos associados principalmente Ãs vibraÃÃes atribuÃdas à carboxila (CO2-), amina...

  6. Transplante alogênico de células-tronco hematopoéticas em leucemias agudas: a experiência de dez anos do Hospital das Clínicas da UFMG Allogeneic hematopoietic stem cells transplantation in acute leukemia: ten years of experience in the Hospital das Clínicas - UFMG

    Directory of Open Access Journals (Sweden)

    Rosana M. Lamego

    2010-01-01

    Full Text Available As leucemias agudas são doenças com alta morbimortalidade para as quais o transplante alogênico de medula óssea é uma opção terapêutica eficaz. Neste artigo, relatamos a experiência de um centro brasileiro com pacientes apresentando leucemia aguda que receberam um enxerto de medula óssea ou células-tronco periféricas de um doador familiar HLA idêntico no período de julho de 1995 a dezembro de 2005. Foi realizado um estudo de coorte retrospectivo, analisando dados de 125 pacientes com mediana de idade de 28,7 anos. Oitenta e um pacientes (64,8% apresentavam leucemia mieloide aguda; 38 (30,4%, leucemia linfoide aguda; e seis (4,8%, leucemia bifenotípica. Trinta e dois pacientes encontravam-se em primeira remissão completa, 23 em segunda remissão e 70 com doença avançada (refratários, recidivados ou além da segunda remissão. A sobrevida global estimada em 10 anos foi de 22,9%. Em relação à situação clínica do paciente no momento do transplante, a sobrevida global em dez anos foi de 56,3% para pacientes em primeira remissão, 38% para os pacientes em segunda remissão, e 3,7% para os pacientes com doença avançada. Considerando-se os pacientes transplantados em primeira e segunda remissão, a evolução foi semelhante aos dados disponíveis na literatura. Entretanto, os resultados dos pacientes transplantados em fase avançada foram ruins, devendo-se discutir o papel do transplante para este grupo.Acute leukemias are a group of diseases with high morbimortality. Allogeneic bone marrow transplantation is an efficacious therapeutic option for their treatment. We report the experience of a Brazilian center in respect to acute leukemia patients who received a bone marrow or peripheral blood allograft from a HLA-matched sibling from July 1995 to December 2005. Data were retrospectively collected. The median age of the 125 patients included in the study was 28.7 years. Eighty-one patients presented with acute myeloid leukemia

  7. Importância da detecção das mutações no gene FLT3 e no gene NPM1 na leucemia mieloide aguda - Classificação da Organização Mundial de Saúde 2008 Importance of detecting FLT3 and NPM1 gene mutations in acute myeloid leukemia -World Health Organization Classification 2008

    Directory of Open Access Journals (Sweden)

    Marley Aparecida Licínio

    2010-01-01

    Full Text Available As leucemias mieloides agudas (LMA constituem um grupo de neoplasias malignas caracterizadas pela proliferação descontrolada de células hematopoéticas, decorrente de mutações que podem ocorrer em diferentes fases da diferenciação de células precursoras mieloides. Em 2008, a Organização Mundial da Saúde (OMS-2008 publicou uma nova classificação para neoplasias do sistema hematopoético e linfoide. De acordo com essa classificação, para um diagnóstico mais preciso e estratificação de prognóstico de pacientes com leucemias mieloides agudas, devem-se pesquisar mutações nos genes FLT3 e NPM1. Sabe-se que a presença de mutações no gene FLT3 é de prognóstico desfavorável e que as mutações no gene NPM1 do tipo A são de prognóstico favorável. Assim, nos países desenvolvidos, a análise das mutações no gene FLT3 e NPM1 tem sido considerada como um fator de prognóstico importante na decisão terapêutica em pacientes com diagnóstico de leucemias mieloides agudas. Considerando essas informações, é de extrema importância a análise das mutações no gene FLT3 (duplicação interna em tandem - DIT - e mutação pontual D835 e no gene NPM1 como marcadores moleculares para o diagnóstico, o prognóstico e a monitoração de doença residual mínima em pacientes com leucemias mieloides agudas.Acute myeloid leukemia (AML is a group of malignancies characterized by uncontrolled proliferation of hematopoietic cells resulting from mutations that occur at different stages in the differentiation of myeloid precursor cells. In 2008, the World Health Organization (WHO-2008 published a new classification for cancers of the hematopoietic and lymphoid system. According to this classification, FLT3 and NPM1 gene mutations should be investigated for a more precise diagnosis and prognostic stratification of AML patients. It is well known that the presence of FLT3 gene mutations is considered an unfavorable prognostic factor and type

  8. Protein source in a high-protein diet modulates reductions in insulin resistance and hepatic steatosis in fa/fa Zucker rats.

    Science.gov (United States)

    Wojcik, Jennifer L; Devassy, Jessay G; Wu, Yinghong; Zahradka, Peter; Taylor, Carla G; Aukema, Harold M

    2016-01-01

    High-protein diets are being promoted to reduce insulin resistance and hepatic steatosis in metabolic syndrome. Therefore, the effect of protein source in high-protein diets on reducing insulin resistance and hepatic steatosis was examined. Fa/fa Zucker rats were provided normal-protein (15% of energy) casein, high-protein (35% of energy) casein, high-protein soy, or high-protein mixed diets with animal and plant proteins. The high-protein mixed diet reduced area under the curve for insulin during glucose tolerance testing, fasting serum insulin and free fatty acid concentrations, homeostatic model assessment index, insulin to glucose ratio, and pancreatic islet cell area. The high-protein mixed and the high-protein soy diets reduced hepatic lipid concentrations, liver to body weight ratio, and hepatic steatosis rating. These improvements were observed despite no differences in body weight, feed intake, or adiposity among high-protein diet groups. The high-protein casein diet had minimal benefits. A high-protein mixed diet was the most effective for modulating reductions in insulin resistance and hepatic steatosis independent of weight loss, indicating that the source of protein within a high-protein diet is critical for the management of these metabolic syndrome parameters. © 2015 The Obesity Society.

  9. In Plane Loaded Glass Panes in Façades, Temperature Loads in Fixed Bonded Glass Panes

    NARCIS (Netherlands)

    Huveners, E.M.P.; Herwijnen, van F.; Soetens, F.; Hofmeyer, H.; Vitkala, J.

    2005-01-01

    The author discusses the use of glass panes as transparent stability elements in vertical façade structures subjected to in-plane loads including temperature loads. In the present façade architecture, glass is normally used non-structural. The only mechanical requirement is to resist transversal

  10. FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression

    DEFF Research Database (Denmark)

    Tornehave, D; Jensen, Charlotte Harken; Teisner, B

    1996-01-01

    Fetal antigen 1 (FA1) is a glycoprotein containing six epidermal growth factor (EGF)-like repeats. It is closely similar to the protein translated from the human delta-like (dlk) cDNA and probably constitutes a proteolytically processed form of dlk. dlk is homologous to the Drosophila homeotic...... proteins delta and notch and to the murine preadipocyte differentiation factor Pref-1. These proteins participate in determining cell fate choices during differentiation. We now report that FA1 immunoreactivity is present in a number of neuroectodermally derived tumours as well as in pancreatic endocrine...... tumours. A negative correlation between FA1 and glucagon immunoreactants in these tumours prompted a reexamination of FA1 immunoreactants during fetal pancreatic development. At the earliest stages of development, FA1 was expressed by most of the non-endocrine parenchymal cells and, with ensuing...

  11. The catalytic kinetic method for the determination of trace formaldehyde (FA) base on a bromate-eosin Y system

    Science.gov (United States)

    Tang, Yufang; Chen, Hao; Weng, Chao; Tang, Xiaohui; Zhang, Miaoling; Yang, Qiongqiong; Hu, Tao; Cai, Changqun

    A new simple and highly sensitive catalytic kinetic method for the determination of trace amount of FA in food sample has been established. The method was based on the catalytic effect of FA on the oxidation of eosin Y by potassium bromate in present of phosphoric acid. The reaction was monitored spectrophotometrically by measuring the decrease in absorbance of eosin Y at 518 nm. Under the optimized experimental conditions, the developed method allowed the determination of FA in the range of 0.03-0.6 μg mL-1 with a good precision, and the limit of detection was down to 0.00988 μg mL-1. The relative standard deviation of five replicate measurements for the determination of FA in concentration 0.12 μg mL-1 was 1.8%. The proposed method was successfully applied to the determination of FA in food directly and satisfactory results were obtained.

  12. Repopulation of FaDu human squamous cell carcinoma during fractionated radiotherapy correlates with reoxygenation

    International Nuclear Information System (INIS)

    Petersen, Cordula; Zips, Daniel; Krause, Mechthild; Schoene, Kerstin; Eicheler, Wolfgang; Hoinkis, Cordelia; Thames, Howard D.; Baumann, Michael

    2001-01-01

    Purpose: FaDu human squamous cell carcinoma (FaDu-hSCC) showed a clear-cut time factor during fractionated radiotherapy (RT) under ambient blood flow. It remained unclear whether this is caused solely by proliferation or if radioresistance resulting from increasing hypoxia contributed to this phenomenon. To address this question, repopulation of clonogenic FaDu cells during fractionated RT under clamp hypoxia was determined by local tumor control assays, and compared to the results after irradiation with the same regimen under ambient blood flow. Methods and Materials: FaDu-hSCC was transplanted into the right hind leg of NMRI nu/nu mice. In the first set of experiments, irradiation was performed under clamp hypoxia. After increasing numbers of 3 Gy fractions (time intervals 24 h or 48 h), graded top-up doses were given to determine the TCD 50 (dose required to control 50% of the tumors). In the second set of experiments, all 3 Gy fractions were applied under ambient conditions, but as in the previous experiments the graded top-up doses were given under clamp hypoxia. A total of 26 TCD 50 assays were performed and analyzed using maximum likelihood techniques. Results: With increasing numbers of daily fractions, the top-up TCD 50 under clamp hypoxia decreased from 39.4 Gy [95% CI 36, 42] after single dose to 19.8 Gy [15, 24] after 18 fractions in 18 days and to 37.8 Gy [31, 44] after 18 fractions in 36 days. The results were consistent with biphasic repopulation, with a switch to rapid repopulation after about 22 days [13, 30]. The clonogen doubling time (T clon ) decreased from 9.8 days [0, 21] in the beginning of RT to 3.4 days after 22 days. Under ambient blood flow the top-up TCD 50 decreased from 37.6 Gy [34, 40] after single dose irradiation to 0 Gy [0, 1] after 18 fractions in 18 days and 22.4 Gy [18, 27] after 18 fractions in 36 days. Similar to results from irradiations under clamp hypoxia, the ambient data were consistent with a biphasic course of clonogen

  13. The role of FaBG3 in fruit ripening and B. cinerea fungal infection of strawberry.

    Science.gov (United States)

    Li, Qian; Ji, Kai; Sun, Yufei; Luo, Hao; Wang, Hongqing; Leng, Ping

    2013-10-01

    In plants, β-glucosidases (BG) have been implicated in developmental and pathogen defense, and are thought to take part in abscisic acid (ABA) synthesis via hydrolysis of ABA glucose ester to release active ABA; however, there is no genetic evidence for the role of BG genes in ripening and biotic/abiotic stress in fruits. To clarify the role of BG genes in fruit, eight Fa/FvBG genes encoding β-glucosidase were isolated using information from the GenBank strawberry nucleotide database. Of the Fa/FvBG genes examined, expression of FaBG3 was the highest, showing peaks at the mature stage, coincident with the changes observed in ABA content. To verify the role of this gene, we suppressed the expression of FaBG3 via inoculation with Agrobacterium tumefaciens containing tobacco rattle virus carrying a FaBG3 fragment (RNAi). The expression of FaBG3 in FaBG3-RNAi-treated fruit was markedly reduced, and the ABA content was lower than that of the control. FaBG3-RNAi-treated fruit did not exhibit full ripening, and were firmer, had lower sugar content, and were pale compared with the control due to down-regulation of ripening-related genes. FaBG3-RNAi-treated fruit with reduced ABA levels were much more resistant to Botrytis cinerea fungus but were more sensitive to dehydration stress than control fruit. These results indicate that FaBG3 may play key roles in fruit ripening, dehydration stress and B. cinerea fungal infection in strawberries via modulation of ABA homeostasis and transcriptional regulation of ripening-related genes. © 2013 The Authors The Plant Journal © 2013 John Wiley & Sons Ltd.

  14. Virtual endoscopic images by 3D FASE cisternography for neurovascular compression

    International Nuclear Information System (INIS)

    Ishimori, Takashi; Nakano, Satoru; Kagawa, Masahiro

    2003-01-01

    Three-dimensional fast asymmetric spin echo (3D FASE) cisternography provides high spatial resolution and excellent contrast as a water image acquisition technique. It is also useful for the evaluation of various anatomical regions. This study investigated the usefulness and limitations of virtual endoscopic images obtained by 3D FASE MR cisternography in the preoperative evaluation of patients with neurovascular compression. The study included 12 patients with neurovascular compression: 10 with hemifacial spasm and two with trigeminal neuralgia. The diagnosis was surgically confirmed in all patients. The virtual endoscopic images obtained were judged to be of acceptable quality for interpretation in all cases. The areas of compression identified in preoperative diagnosis with virtual endoscopic images showed good agreement with those observed from surgery, except in one case in which the common trunk of the anterior inferior cerebellar artery and posterior inferior cerebellar artery (AICA-PICA) bifurcated near the root exit zone of the facial nerve. The veins are displayed in some cases but not in others. The main advantage of generating virtual endoscopic images is that such images can be used for surgical simulation, allowing the neurosurgeon to perform surgical procedures with greater confidence. (author)

  15. FASES DE RESOLUCIÓN DE UNA SITUACIÓN-PROBLEMA UTILIZANDO ELEMENTOS DE COMPETENCIAS

    Directory of Open Access Journals (Sweden)

    Ester Ruda

    2012-01-01

    Full Text Available El objetivo de este trabajo fue analizar las fases utilizadas para resolver una situación-problema a través de elementos de competencias en el proceso de enseñanza y aprendizaje de una asignatura universitaria. Se analizan las fases a desarrollar (análisis de la situación-problema, identificación de los esquemas de actuación, selección, disposición y aplicación estratégica de los esquemas de actuación; conocimiento, dominio y transferencia de los componentes de la competencia y las evidencias de logro del dominio de los componentes de la competencia. Se aplican los conceptos a un ejemplo para una asignatura del ciclo superior de una carrera relacionada con la química y se discuten los resultados obtenidos. La resolución de una situación-problema implica que los alumnos han adquirido elementos de competencias, han sorteado distintos pasos que implican el dominio de procedimientos que aparecen en toda acción competente y han aplicado interrelacionadamente contenidos conceptuales, actitudinales y procedimentales.

  16. Uso da Valeriana officinalis em dietas de codornas japonesas na fase de postura

    Directory of Open Access Journals (Sweden)

    Rodrigo Antonio Gravena

    2009-06-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2009v22n4p185 Este estudo teve como objetivo avaliar o efeito da Valeriana officinalis sobre o estresse de codornas japonesas na fase postura, analisando-se parâmetros de desempenho, comportamental e fisiolόgico. Foram utilizadas 192 aves dos 43 aos 140 dias de idade, distribuídas em blocos casualizados e submetidas a quatro níveis de valeriana (controle, 250, 500 e 750mg/Ng de ração com oito repetições e seis aves por parcela. Foram avaliados parâmetros de desempenho (conversão alimentar por dúzia de ovos, conversão alimentar por massa de ovos, consumo de ração, peso dos ovos, porcentagem de postura e viabilidade, comportamentais (tempo em imobilidade tônica, observação focal e ferimentos corporais e fisiolόgicos (níveis plasmáticos de corticosterona e relação heterόfilo:linfόcito. Os resultados obtidos na fase de postura demonstraram que a valeriana adicionada na dieta não foi capaz de reduzir o estresse das aves e não afetou o desempenho produtivo.

  17. Injuria renal aguda en la sepsis grave Acute kidney injury in severe sepsis

    Directory of Open Access Journals (Sweden)

    Hernán Trimarchi

    2009-06-01

    Full Text Available La sepsis afecta al 40% de los pacientes críticos, siendo su mortalidad de aproximadamente un 30% en el caso de la sepsis grave, y de 75% con injuria renal aguda, la cual sucede en el 20-51% de los casos. Se realizó un estudio prospectivo, observacional, longitudinal, en 80 pacientes sépticos graves en el lapso de 1 año para determinar el desarrollo de injuria renal aguda y su relación con la mortalidad; correlacionar antecedentes clínicos y variaciones del laboratorio con la mortalidad; determinar la tasa de mortalidad de la sepsis grave; relacionar óbito y foco séptico primario; evaluar la predictibilidad de mortalidad según niveles de creatinina de ingreso y sus variaciones finales. Se definieron dos grupos: Obito (n = 25 y No-óbito (n = 55. Analizados según la creatinina de ingreso, 39 tenían valores normales de creatinina (10 óbitos y 41 la presentaban elevada (15 óbitos; según la creatinina de egreso, 48 presentaron creatinina normal y fallecieron 7, mientras que 32 tenían daño renal agudo, de los cuales 18 fallecieron. De los 25 pacientes fallecidos, el 72% presentaron daño renal. De éstos, 7 pacientes vivos y 2 fallecidos requirieron hemodiálisis. El foco primario más frecuente fue el respiratorio (26.4%. El desarrollo de daño renal es un alto predictor de mortalidad en la sepsis, independientemente de los valores iniciales de creatinina. Edad más avanzada, hipertensión arterial, score APACHE más elevado, anemia más grave, hipoalbuminemia, hiperfosfatemia e hiperkalemia se asociaron a mayor mortalidad. La mortalidad global fue 31.3%. La imposibilidad de identificar el foco séptico primario se asoció a mayor mortalidad. El foco respiratorio se relacionó a mayor riesgo de requerir hemodiálisis.Sepsis affects 40% of critically ill patients, with a reported mortality of approximately 30% in severe sepsis, raising to 75% when acute kidney injury ensues, which occurs in about 20-51% of cases. The present study

  18. Guía para la práctica clínica de las enfermedades diarreicas agudas

    OpenAIRE

    Freijoso Santiesteban, Elsie; Cires Pujol, María Miriam; Silva Herrera, Lázaro; Delgado Martínez, Ibis; Riverón Corteguera, Raúl; Ramírez, Margarita

    2003-01-01

    Se presenta una guía para la práctica clínica de las enfermedades diarreicas agudas (EDA), cuyo objetivo principal es el de establecer recomendaciones para el manejo terapéutico de pacientes con EDA. En la misma se abordan las definiciones y causas de las EDA, los objetivos del tratamiento, la evaluación del paciente con diarreas y las características clínico epidemiológicas, así como las consideraciones terapéuticas y tratamientos para las diarreas causadas por diferentes microorganismos.A c...

  19. Infección respiratoria aguda en niños que acuden a un centro de desarrollo infantil

    Directory of Open Access Journals (Sweden)

    Nandí-Lozano Eugenia

    2002-01-01

    Full Text Available Objetivo. Establecer la incidencia de infección respiratoria y los patrones de colonización faríngea en niños que asisten a guarderías. Material y métodos. Se realizó un estudio de cohorte en niños menores de cuatro años de edad, de uno u otro sexo, asistentes a la guardería del Hospital Infantil de México Federico Gómez, de la Ciudad de México, durante abril a octubre de 1999. Se registró la presencia de infección de vías aéreas superiores cada semana, y de colonización cada tres meses, mediante un exudado nasofaríngeo. Se hizo estadística descriptiva de las variables analizadas. Se determinaron tasas de infección respiratoria aguda. Resultados. Se estudiaron 85 niños, 40 del sexo femenino (47% y 45 del sexo masculino (53% durante un total de 9 090 niños/día de seguimiento. Tres niños tenían antecedentes de atopia (3.52%, seis niños antecedentes de asma (7.05%, y 39 eran expuestos a tabaquismo pasivo (45.88%. Se diagnosticaron 246 rinofaringitis (95.3%, nueve otitis media aguda (3.48%, tres bronquiolitis (1.16%, para un total de 258 eventos de infección respiratoria aguda. La tasa de incidencia global fue de 10.35 infecciones por niño/año de observación (IC 95% 8.7-12.0. La incidencia de otitis y bronquiolitis fue de 0.36 y 0.12 eventos por niño/año de observación. Se tomaron cultivos nasofaríngeos con una prevalencia de colonización para S. pneumoniae de 20.4%, H. influenzae no tipificable 13.1% y Moraxella catarrhalis 8.1%. Conclusiones. Los resultados no sólo demuestran una alta prevalencia de colonización debido a cepas invasivas, sino que también revelan una tasa de incidencia de infección respiratoria aguda del doble de lo reportado en estudios de comunidad. Estos resultados ayudan a caracterizar un problema pobremente documentado en nuestro país.

  20. Consenso intersociedades para el manejo de infecciones respiratorias: bronquitis aguda y enfermedad pulmonar obstructiva crónica

    OpenAIRE

    Gustavo Lopardo; Claudia Pensotti; Pablo Scapellato; Oscar Caberlotto; Aníbal Calmaggi; Liliana Clara; Manuel Klein; Gabriel Levy Hara; María J. López Furst; Analía Mykietiuk; Daniel Pryluka; Maria J. Rial; Claudia Vujacich; Diego Yahni

    2013-01-01

    La Sociedad Argentina de Infectología convocó a otras sociedades científicas para elaborar una guía práctica y actualizada para el manejo del tratamiento antibiótico de las bronquitis agudas (BA) y los episodios de reagudización de enfermedad pulmonar obstructiva crónica (EPOC), con el objetivo de promover el uso racional de los recursos diagnósticos y terapéuticos. La BA se caracteriza por la inflamación del árbol bronquial que afecta tanto a adultos como a niños sin enfermedades pulmonares ...

  1. Tratamiento quirúrgico de la diverticulitis aguda en la Comunidad Valenciana. Estudio multicéntrico.

    OpenAIRE

    Salvador Martínez, Antonio

    2015-01-01

    Diverticulitis aguda. Estado actual y controversias Este término representa un espectro de los cambios inflamatorios que van desde una inflamación local subclínica hasta la peritonitis generalizada con perforación libre. Su mecanismo de aparición gira alrededor de una perforación de un divertículo. El antiguo concepto de obstrucción luminal probablemente represente un hecho raro. El aumento de la presión intraluminal o las partículas espesadas de alimentos pueden erosionar la pared d...

  2. Características clínico epidemiologicas de los pacientes con Leucemia Aguda del Servicio de Hematologia del Hospital Almanzor Aguinaga Asenjo

    OpenAIRE

    Polo-Capuñay, Ana María; Universidad de San Martín de Porres; León-Seminario, Carlos Alberto; Universidad de San Martín de Porres; Pérez-Villena, Joan Flaubert; Universidad de San Martín de Porres; Yovera-Merino, Jhonny David; Universidad de San Martín de Porres; Barraza-Chavesta, Omar; Universidad de San Martín de Porres; Torres-Anaya, Victor; Universidad de San Martín de Porres; Diaz-Vélez., Cristian; Universidad de San Martín de Porres

    2014-01-01

    OBJETIVOIdentificar las características clínico-epidemiológicas de los pacientes con leucemia en el área de Hematología del H.A.A.A.MATERIAL Y MÉTODOEstudio retrospectivo, transversal y descriptivo. Se revisaron 55 historias clínicas de pacientes con diagnóstico de Leucemia Aguda, tomadas de la oficina de registro del HNAAA, durante el periodo de Enero 2005 a Marzo 2010.RESULTADOSEn el periodo de estudio, se diagnosticaron 142 casos de Leucemia, 105 (73.94%) correspondieron a Leucemia aguda. De...

  3. Colesterol y triglicéridos como marcadores bioquímicos del estado de la enfermedad del paciente con leucemia linfocítica aguda

    OpenAIRE

    Marco Guzmán; Miguel Sandoval

    2004-01-01

    Objetivo: Determinar la relación de los niveles séricos de colesterol y triglicéridos con el estado de respuesta al tratamiento quimioterápico de inducción de pacientes con leucemia linfocítica aguda. Material y Métodos: La muestra la conforman 25 pacientes de 2 a 18 años de edad, admitidos al Instituto de Enfermedades Neoplásicas con un diagnóstico reciente de leucemia linfocítica aguda; determinándose en ellos sus concentraciones séricas de colesterol total, colesterol-HDL, colesterol-LDL y...

  4. Aféresis en el tratamiento de pancreatitis aguda hipertrigliceridémica: Reporte de caso y revisión de la literatura

    OpenAIRE

    Zaragoza, José J.; Villa, Gianluca; Borbolla-Arizti, Juan Pablo; Salgado-Hernández, Turmalina; Cerón-Díaz, Ulises

    2015-01-01

    La hipertrigliceridemia severa está asociada con varias patologías incluyendo pancreatitis aguda. Las opciones de tratamiento para la pancreatitis aguda hipertrigliceridémica incluyen insulina, glucosa y heparina en infusión, así como muchos tipos de aféresis. Los pacientes se pueden beneficiar del uso temprano de recambio plasmático para reducir los niveles de lípidos en sangre. El tiempo de inicio y el tipo de terapia juegan un papel importante para conseguir los beneficios completos del pr...

  5. Nutrición parenteral total en una paciente gestante con pancreatitis aguda e hipertrigliceridemia por déficit de lipoproteín lipasa

    OpenAIRE

    Contreras-Bolívar, Victoria; González-Molero, Inmaculada; Valdivieso, Pedro; Olveira, Gabriel

    2015-01-01

    Presentamos un caso de pancreatitis aguda severa inducida por hipertrigliceridemia secundaria a déficit de lipoproteín lipasa (LPL) en una paciente gestante con diabetes gestacional, manejada inicialmente con dieta, siendo necesario posteriormente llevar a cabo medidas de soporte nutricional artificial: nutrición parenteral total. El déficit de LPL causa hipertrigliceridemia severa y, frecuentemente, pancreatitis aguda de repetición, situación de difícil manejo y de importante gravedad durant...

  6. Amigdalitis aguda recurrente bacteriana: Estudio prospectivo, comparativo y controlado de sus características clínicas y microbiológicas

    OpenAIRE

    Der M,Carolina; Iñiguez C,Rodrigo; Guzman D,Ana Maria; Jofré P,David; Iñiguez C,Armando; Labarca L,Jaime

    2007-01-01

    Introducción: La amigdalitis aguda recurrente es una patología de frecuente consulta, es una de las indicaciones de amigdalectomía. No se sabe con exactitud el origen de esta patología. Objetivo: Identificar la microbiología y patrones de susceptibilidad de las bacterias en la amigdalitis aguda recurrente bacteriana (AARB) a los antimicrobianos más comúnmente en el medio nacional, usados en su tratamiento. Material y método: Se planificó un estudio prospectivo, controlado y ciego. Se evaluaro...

  7. Efecto de los inotrópicos sobre la mortalidad en falla cardiaca aguda. Metaanálisis en red de ensayos clínicos

    OpenAIRE

    Juan M. Sénior; Edison Muñoz; James Díaz

    2017-01-01

    Introducción: en pacientes con falla cardiaca aguda es necesario el uso de inotrópicos para lograr su estabilización. Objetivo: definir cuál de los medicamentos inotrópicos se asocia con menor mortalidad. Metodología: se realizó un metaanálisis en red con la aproximación frecuentista. La búsqueda sistemática incluyó PUBMED, EMBASE, CENTRAL, DARE, Epistemonikos, SieELO, LILACS y OpenGray. Se incluyeron ensayos clínicos con asignación aleatoria en pacientes con falla cardiaca aguda que re...

  8. Apendicitis aguda en el paciente senil: Factores asociados a una mayor morbimortalidad post operatoria

    Directory of Open Access Journals (Sweden)

    Víctor Eduardo Chian Chang

    1996-04-01

    Full Text Available Objetivo: Definir los factores asociados a una mayor morbilidad y mortalidad en pacientes seniles con apendicitis aguda. Material y métodos: Se realizó un estudio retrospectivo con 100 pacientes intervenidos en el Hospital Nacional Arzobispo Loayza, durante el período comprendido entre 1984 a 1994. Resultados: Se asociaron a una mayor frecuencia de complicaciones postoperatorias: edad mayor o igual a 70 años, tiempo de enfermedad mayor de 48 horas, presencia de apendicitis perforada con peritonitis localizada o generalizada (p<0.05. Además la presencia de apendicitis perforada se asoció significativamente a la presencia de absceso residual y/o fístula estercorácea (p=0.027 y la presencia de AA gangrenosa o perforada a mayor frecuencia de infección de herida operatoria (p<0.05. El antecedente de patología cardiovascular previa se asoció a mayor frecuencia de complicaciones cardiovasculares (p<0.05. Se asociaron a mayor mortalidad en AA, pacientes con intervención quirúrgica adicional a la apendicetomía (p=0.016 y presencia de AA perforada (p=0.027. Conclusiones: Los estadios avanzados de AA, así como la presencia de problema cardiovascular al momento del diagnóstico se asociaron con una mayor frecuencia de complicaciones post-operatorias. La presencia de peritonitis se asocia con la mortalidad. (Rev Med Hered 1996; 7: 62-67.

  9. Infecciones respiratorias agudas y factores asociados Acute respiratory infections and associated factors

    Directory of Open Access Journals (Sweden)

    Rogelio León López

    2005-12-01

    Full Text Available Se realizó un estudio descriptivo y retrospectivo con la finalidad de conocer la relación entre las infecciones respiratorias agudas con algunos factores asociados seleccionados en lactantes, durante el trienio 2001-2003, en el área de salud del Policlínico Docente “30 de Noviembre”, del municipio 10 de Octubre. La incidencia de estas enfermedades en el mencionado período fue de 933 x 1 000. Se encontró que la mayoría de los infantes exhibió un adecuado estado inmunológico y nutricional, así como también que no tenían historia de alergia respiratoria. La institucionalización de estos niños no influyó en la aparición de estas enfermedades, y el tratamiento que predominó fue el sintomático.A descriptive and retrospective study was conducted to know the relation between acute respiratory infections and some associated factors selected in infants from the health area of “30 de Noviembre” Teaching Polyclinic, in “10 de Octubre” municipality, between 2001 and 2003. The incidence of these diseases in the above period was 933 x 1000. It was observed that most of the infants had an adequate immunological and nutritional state, and that they did not have any history of respiratory allergy. The institutionalization of these children did not influence on the appearance of these diseases. There was a predominance of the symptomatic treatment.

  10. INSUFICIENCIA RENAL AGUDA EN EL ANCIANO. CONSIDERACIONES ACERCA DE SU VALORACIÓN Y TRATAMIENTO.

    Directory of Open Access Journals (Sweden)

    Musso CG

    2005-02-01

    Full Text Available RESUMEN:La insuficiencia renal aguda (IRA es un trastorno frecuente en los ancianos a raíz de la senescencia renal, la menor metabolización de los fármacos y la mayor exposición a la polifarmacia y enfermedades sistémicas que ellos padecen. Las siguientes son las principales características de la IRA en el anciano: carácter multifactorial, presentación clínica atípica, fragilidad tubular, patrón de síndrome intermedio y poca fiabilidad del examen físico y de los índices urinarios en la interpretación de su etiología. Las medidas de profilaxis y rehidratación siguen siendo los mejores tratamientos de la IRA en el viejo. La biopsia renal y la diálisis tienen el mismo rol tanto en el grupo senil como en el joven.ABSTRACTACUTE RENAL FAILURE IN THE ELDERLY: PEARLS FOR ITS ASSESSMENT AND TREATMENT.Acute renal failure (ARF is a frequent disorder in the elderly, and this phenomenon is due to the senescence process, reduced metabolization of drugs, increased exposure to polypharmacy and systemic diseases of the aged group. The following are the main characteristics of the ARF in the elderly: mulfactorial, atypical presentation, tubular frailty, intermediate syndrome pattern, low reliable physical examination and urinary indeces. Profilaxis and rehydration are the best treatments for ARF in the old population. Renal biopsy and dialysis have the same role in young and old people.

  11. A sepse como causa de lesão renal aguda: modelo experimental

    Directory of Open Access Journals (Sweden)

    Carolina Ferreira Pinto

    2012-10-01

    Full Text Available A sepse associada à falência de múltiplos órgãos como a lesão renal aguda (LRA demonstra alta taxa de mortalidade no paciente crítico. Este estudo investigou a LRA induzida pela sepse em modelo experimental. Foram utilizados ratos da raça Wistar, adultos e machos divididos nos seguintes grupos: Controle - controle cirúrgico e Sepse - indução da sepse pela ligadura e punção do cécon (LPC. Foram avaliados os parâmetros fisiológicos (temperatura retal, pressão arterial média - PAM, glicemia sérica e fluxo urinário; a função renal (clearance de creatinina; o estresse oxidativo (peróxidos urinários e substâncias reativas com ácido tiobarbitúrico - TBARS e realizada a análise histológica renal. O estudo conclui que a LRA induzida pela sepse caracteriza-se por lesão endotelial com disfunção hemodinâmica, liberação de mediadores inflamatórios e geração de espécies reativas de oxigênio (EROs por células tubulares, caracterizando-se como uma associação de vasoconstrição renal de origem hemodinâmica e inflamatória.

  12. Citarabina y reacciones cutáneas en leucemia aguda mieloide

    Directory of Open Access Journals (Sweden)

    Sofía Grille

    2013-12-01

    Full Text Available La citarabina es un antimetabolito utilizado en el tratamiento de las leucemias agudas mieloides (LAM. Esta droga presenta numerosos efectos adversos (mielosupresión, toxicidad en sistema nervioso central, hepática, gastrointestinal, ocular y cutánea. La toxicidad dermatológica es habitualmente descrita como rara, sin embargo existen diferencias en la incidencia comunicada. Se realizó un estudio retrospectivo donde se incluyeron todas las LAM tratadas con quimioterapia que incluía citarabina, entre el 1º de julio 2006 y el 1° de julio 2012. Se incluyeron 46 pacientes con una mediana de edad de 55 años. La incidencia global de reacciones cutáneas fue de 39% (n = 18. La presencia de lesiones cutáneas no se asoció con sexo, edad, antecedentes de atopía, de reacciones medicamentosas, tipo de LAM ni dosis de citarabina utilizada. Las lesiones se observaron entre 2 a 8 días de iniciado el tratamiento. En cuanto al grado lesional, 27.8% presentaron grado 1, 38.9% grado 2 y 33.3% grado 3. No existieron lesiones grado 4 ni muerte vinculada a toxicidad cutánea. En cuanto al tipo de lesiones, 55.6% se presentaban con máculas, 22.2% con pápulas y 22.2% con eritema. Con respecto a la distribución de las lesiones, 52% de los pacientes presentaron una distribución difusa, 39.3% acral y 8.7% a nivel flexural. Las reacciones adversas cutáneas con la administración de citarabina son frecuentes en nuestro medio, en algunos casos con afectación grave. Si bien suelen resolverse espontáneamente, pueden determinar mayor riesgo de infección, así como comprometer la calidad de vida.

  13. Actividad antiulcerosa y toxicidad aguda oral de celulosa microcristalina suspensión al 12 %

    Directory of Open Access Journals (Sweden)

    Pedro Gilberto Barzaga Fernández

    Full Text Available La celulosa microcristalina ha sido usada recientemente en el tratamiento de la gastritis alcalina por reflujo biliar duodenogástrico. Se realizó un estudio toxicológico y se evaluó el efecto antiulceroso de celulosa microcristalina suspensión al 12 % en ratas. La determinación de la toxicidad aguda oral se realizó mediante el ensayo de dosis límite, mediante la administración de una dosis de 2 000 mg/kg a animales de uno y otro sexos. El efecto protector sobre la mucosa gástrica se evaluó sobre lesiones inducidas por taurocolato de sodio y se ensayaron las dosis de 240, 360 y 540 mg/kg de la suspensión. Como resultado en el estudio toxicológico, no se produjo mortalidad para la dosis ensayada, por lo que se clasificó la sustancia como no tóxica. Mientras que las diferentes dosis empleadas para el efecto antiulceroso disminuyeron el número y la intensidad de las lesiones significativamente de manera dosis dependiente. La dosis efectiva media fue de 356,8 mg/kg. Tales hallazgos permiten sugerir que el efecto protector de celulosa microcristalina suspensión al 12 % podría estar dado por una inactivación de los ácidos biliares o por una alteración en la cantidad o composición de la capa de moco que recubre la mucosa gástrica.

  14. Enfermedad diarreica aguda por Escherichia coli patógenas en Colombia

    Science.gov (United States)

    Gómez-Duarte, Oscar G.

    2014-01-01

    Resumen Las cepas de E. coli patógenas intestinales son causas importantes de la enfermedad diarreica aguda (EDA) en niños menores de 5 años en América Latina, África y Asia y están asociadas a alta mortalidad en niños en las comunidades más pobres de África y el Sudeste Asiático. Estudios sobre el papel de las E. coli patógenas intestinales en la EDA infantil en Colombia y otros países de América Latina son limitados debido a la carencia de ensayos para detección de estos patógenos en los laboratorios clínicos de centros de salud. Estudios recientes han reportado la detección de E. coli patógenas intestinales en Colombia, siendo la E. coli enterotoxigénica la cepa más frecuentemente asociada a diarrea en niños menores de 5 años. Otros patógenos detectados en estos pacientes incluyen las E. coli enteroagregativa, enteropatógena, productora de toxina Shiga, y de adherencia difusa. Con base en estudios que reportan la presencia de E. coli productora de toxina Shiga y E. coli enteroagregativa en carnes y vegetales en supermercados, se cree que productos alimentarios contaminados contribuyen a la transmisión de estos patógenos y a la infección del huésped susceptible. Más estudios son necesarios para evaluar los mecanismos de transmisión, el impacto en la epidemiologia de la EDA, y las pautas de manejo y prevención de estos patógenos que afectan la población pediátrica en Colombia. PMID:25491457

  15. Injúria renal aguda: um alerta global Acute kidney injury: a global alert

    Directory of Open Access Journals (Sweden)

    Philip Kam Tao Li

    2013-03-01

    Full Text Available A Injúria Renal Aguda (IRA é cada vez mais prevalente nos países desenvolvidos e nos em desenvolvimento, e está associada com morbidade e mortalidade severas. A maioria das causas da IRA pode ser evitada por meio de intervenções em nível individual, comunitário, regional e intra-hospitalar. Medidas efetivas devem incluir, em toda a comunidade, os esforços para aumentar a consciência dos efeitos devastadores do IRA e fornecer orientações sobre as estratégias de prevenção, bem como o reconhecimento e tratamento precoces. Os esforços devem ser focados em minimizar as causas de IRA, aumentando a consciência da importância de medidas seriadas de creatinina sérica em pacientes de alto risco para IRA, e documentar o volume de urina em pessoas gravemente doentes para obtenção de diagnóstico precoce; até o momento, não há ainda um papel definitivo para outros biomarcadores. Há a necessidade de protocolos para sistematizar a conduta em condições de IRA pré-renal e em infecções específicas. Dados mais precisos sobre a verdadeira incidência e o impacto clínico da IRA ajudarão a melhor conhecer a importância desta doença, a aumentar o conhecimento de IRA por parte dos governantes, dos médicos em geral e de outros profissionais de saúde para ajudar na prevenção da doença. A prevenção é a chave para evitar a pesado ônus de mortalidade e morbidade associada com IRA.

  16. Injuria renal aguda, perfil epidemiológico intrahospitalario y factores asociados al riesgo de muerte

    Directory of Open Access Journals (Sweden)

    Cristian León

    2014-10-01

    Full Text Available La injuria renal aguda (IRA es un evento mórbido de gran impacto en la vida de las personas. La tasa de letalidad de la IRA ha sido un tema relevante y se han estudiado muchos factores relacionados. Objetivos: Determinar el perfil epidemiológico de los pacientes con IRA en un hospital de Lima y los factores asociados a la mortalidad durante el periodo de hospitalización. Material y métodos: Estudio descriptivo, retrospectivo de una cohorte de pacientes incidentes con diagnóstico de IRA. Se calculó la letalidad bruta y la ajustada a tiempo de permanencia hospitalaria. Se usó la regresión multivariante de Cox, así como el mejor modelo para regresión logística binaria asociada a letalidad. Se aceptó una significancia estadística de p<0,05. Resultados: Se identificaron 90 pacientes con IRA en los años 2002, 2003 y 2004 (incidencia de 30, 39 y 21 pacientes/año, respectivamente. Su permanencia hospitalaria fue 13,44 ± 1,66 (promedio±1ES días, la tasa bruta de letalidad 39% y la tasa ajustada 2,89 fallecidos/100 días de hospitalización. Las variables relacionadas al riesgo de muerte en el tiempo fueron el estado de shock, el diagnóstico de sepsis y la disfunción respiratoria al momento de la admisión. Conclusiones: La gravedad clínica como condición al momento de la admisión al centro hospitalario, el estado séptico y la presencia de disfunción respiratoria, fueron los factores que influenciaron en el pronóstico de supervivencia de pacientes con IRA.

  17. Experimental verification of FA for WWER-1000. Investigations of TVS - 2M

    International Nuclear Information System (INIS)

    Vasilchenko, I.; Seleznev, A.; Kobelev, S.; Makarov, V.; Afanasjev, A.; Matvienko, I.; Enin, A.; Ustimenko, A.; Volkov, S.

    2008-01-01

    During development of TVS-2M design for WWER-1000 and within the scope of its pre-reactor verification there was performed a complex of bench tests of FA for operational impacts. These tests were carried out with the use of the full-scale non-irradiated FA dummy and the models of units. The present report presents the methods and the results of tests of the full-scale dummy for static concentrated loads, impact of thermal cycling and vibration under separate and simultaneous impact of the listed loads. The results of tests carried out indicate that the solutions implemented in TVS-2M, first of all, a rigid welded skeleton, provide much higher resistance to distortion due to thermomechanical loads in comparison with zirconium AFA of the previous generation. This work was organized by JSC TVEL. (authors)

  18. Insulin like growth factor-1/insulin bypasses Pref-1/FA1-mediated inhibition of adipocyte differentiation

    DEFF Research Database (Denmark)

    Zhang, Hongbin; Nøhr, Jane; Jensen, Charlotte Harken

    2003-01-01

    that forced expression of the soluble form, FA1, or full-length Pref-1 did not inhibit adipocyte differentiation of 3T3-L1 cells when differentiation was induced by standard treatment with methylisobutylxanthine, dexamethasone, and high concentrations of insulin. However, forced expression of either form...... of Pref-1/FA1 in 3T3-L1 or 3T3-F442A cells inhibited adipocyte differentiation when insulin or insulin-like growth factor-1 (IGF-1) was omitted from the differentiation mixture. We demonstrate that the level of the mature form of the IGF-1 receptor is reduced and that IGF-1-dependent activation of p42/p44...... mitogen-activated protein kinases (MAPKs) is compromised in preadipocytes with forced expression of Pref-1. This is accompanied by suppression of clonal expansion and terminal differentiation. Accordingly, supplementation with insulin or IGF-1 rescued p42/p44 MAPK activation, clonal expansion...

  19. An Experimental Study on Mitigating Alkali Silica Reaction by Using Fly Ash (FA in Combination with Silica Fume and Expanded Perlite Powder (EPP

    Directory of Open Access Journals (Sweden)

    Isneini Mohd

    2016-01-01

    Full Text Available ASR suppression by FA, SF, EPP, FA in combination with SF and EPP were evaluated by both mortar bar and concrete prism test. Mortar bars were made based on JIS A 1146, meanwhile concrete prism bars were casted in accordance with Rilem AAR-3. Both specimens were stored in 40°C 100% R.H. controlled room. Mortar and concrete mixtures used reactive aggregate in pessimum proportion. The results indicated that FA in combination with SF and EPP showed smaller expansion compared to FA. The best of concrete mixtures in reducing expansion is combination of FA with SF (FA15SF10.

  20. FA composition of heart and skeletal muscle during embryonic development of the king penguin.

    Science.gov (United States)

    Decrock, Frederic; Groscolas, Rene; Speake, Brian K

    2002-04-01

    Since the yolk lipids of the king penguin (Aptenodytes patagonicus) naturally contain the highest concentrations of DHA and EPA yet reported for the eggs of any avian species, the effects of this (n-3)-rich yolk on the FA profiles of the embryonic heart and skeletal muscle were investigated. The concentrations (mg/g wet tissue) of phospholipid (PL) in the developing heart and leg muscle of the penguin doubled between days 27 and 55 from the beginning of egg incubation (i.e., from the halfway stage of embryonic development to 2 d posthatch), whereas no net increase occurred in pectoral muscle. During this period, the concentration of TAG in heart decreased by half but increased two- and sixfold in leg and pectoral muscle, respectively. The most notable change in cholesteryl ester concentration occurred in pectoral muscle, increasing ninefold between days 27 and 55. Arachidonic acid (ARA) was the major polyunsaturate in PL of the penguin's heart, where it formed about 20% (w/w) of FA at day 55. At the equivalent developmental stage, the heart PL of the chicken contained a 1.3-fold greater proportion of ARA, contained a fifth less DHA, and was almost devoid of EPA, whereas the latter FA was a significant component (7% of FA) of penguin heart PL. Similarly, in PL of leg and pectoral muscle, the chicken displayed about 1.4-fold more ARA, up to 50% less DHA, and far less EPA in comparison with the penguin. Thus, although ARA-rich PL profiles are achieved in the heart and muscle of the penguin embryo, these profiles are significantly affected by the high n-3 content of the yolk.

  1. Evaluation of dentoskeletal effects of Farmand functional appliance (Fa II) on class II malocclusion

    OpenAIRE

    Yassaei S.; Aghili H.; Razeghi D.

    2007-01-01

    Background and Aim: Functional appliances refer to a variety of removable or fixed appliances designed to alter the mandibular position both sagitally and vertically, resulting in orthodontic and orthopedic changes. Despite the long history of functional appliances, there is still much controversy related to their effectiveness and mode of action. The aim of this study was to evaluate dental and skeletal effects of Fa II in patients with class II malocclusion due to mandibular deficiency.Mate...

  2. FaCE: a tool for Three Body Faddeev calculations with core excitation

    OpenAIRE

    Thompson, I. J.; Nunes, F. M.; Danilin, B. V.

    2004-01-01

    FaCE is a self contained programme, with namelist input, that solves the three body Faddeev equations. It enables the inclusion of excitation of one of the three bodies, whilst the other two remain inert. It is particularly useful for obtaining the binding energies and bound state structure compositions of light exotic nuclei treated as three-body systems, given the three effective two body interactions. A large variety of forms for these interactions may be defined, and supersymmetric transf...

  3. Aggressive Recurrence of Oral Squamous Cell Carcinoma in a patient with Fanconi’s Anaemia (FA)

    LENUS (Irish Health Repository)

    Nolan, M.

    2017-03-01

    Fanconi’s Anaemia is a rare autosomal recessive disease for which the incidence of head and neck cancer can be increased 700-fold1. We report a case of a 31-year old Caucasian male with FA who initially presented in July 2007 with oral squamous cell carcinoma for which he received radical surgery and radiotherapy. He was disease-free until August 2015 when he presented with an extremely aggressive recurrence.

  4. Concept and development status of fast breeder reactor fuels in the FaCT project

    International Nuclear Information System (INIS)

    Maeda, S.; Suzuki, M.; Kaito, T.; Tanaka, K.; Abe, T.

    2013-01-01

    The fuel development and the conceptual design study have been progressed in the first phase of the FaCT project in Japan. Significant outcomes of key technologies related to fuel design, fuel properties, core materials, fuel fabrication have been provided. The prospects of these technologies have been identified. After the Fukushima accident, the research and development for reducing the amount and toxic level of radioactive wastes will be promoted more than before. These outcomes will be reflected on the future development

  5. Wind tunnel study of natural ventilation of building integrated photovoltaics double skin façade

    Directory of Open Access Journals (Sweden)

    Hudişteanu Sebastian Valeriu

    2018-01-01

    Full Text Available The paper presents a wind tunnel experimental analysis of a small-scale building model (1:30. The objective of the study is to determine the wind influence on the ventilation of a double skin façade channel (DSF and the cooling effect over integrated photovoltaic panels. The tests were achieved by conceiving and implementation of an experimental program using a wind tunnel with atmospheric boundary layer. The effect of the wind over the ventilation of the horizontal channels of double skin façades is evaluated for different incident velocities. The results are generalized for the average steady state values of the velocities analysed. The experimental results put in evidence the correlation between the reference wind velocity and the dynamics of the air movement inside the double skin façade. These values are used to determine the convective heat transfer and the cooling effect of the air streams inside the channel upon the integrated photovoltaic panels. The decrease of the photovoltaic panels temperature determines a raise of 11% in efficiency and power generated.

  6. EPS insulated façade fires from a fire and rescue perspective

    Directory of Open Access Journals (Sweden)

    Kumm M.

    2013-11-01

    Full Text Available This paper highlights the challenges the fire and rescue services can meet at façade fires involving EPS insulation during construction and use of a building. The EPS characteristics are discussed in respect to the fire and rescue operation and results from orientating fire tests performed at a fire and rescue services training and test field are presented. Types of evacuation solutions, involving the fire and rescue services, where façade fires can delay or completely rule out the possibilities for safe evacuation, are presented. The restrictions in the Swedish building codes regarding use of combustible insulation are analysed and reflections over the practical problems with following the instructions to keep an EPS insulated façade safe through the building's whole lifespan are made. A number of occurred fires involving EPS are discussed and analysed from a fire and rescue perspective. Finally, recommendations are given for the fire and rescue services and future research fields are proposed.

  7. [Data mining analysis of professor Li Fa-zhi AIDS herpes zoster medical record].

    Science.gov (United States)

    Wang, Dan-Ni; Li, Zhen; Xu, Li-Ran; Guo, Hui-Jun

    2013-08-01

    Analysis of professor Li Fa-zhi in the treatment of AIDS drug laws of herpes zoster and postherpetic neuralgia, provide reference for the use of Chinese medicine treatment of AIDS, herpes zoster and postherpetic neuralgia. By using the method of analyzing the complex network of Weishi county, Henan in 2007 October to 2011 July during an interview with professor Li Fa-zhi treatment of AIDS of herpes zoster and postherpetic neuralgia patients, patients are input structured clinical information collection system, into the analysis of the data, carries on the research analysis theory of traditional Chinese medicine compatibility system algorithm and complex network analysis the use of complex networks. The use of multi-dimensional query analysis of AIDS drugs, the core of herpes zoster and postherpetic neuralgia treated in this study are Scutellariae Radix, Glucyrrhizae Radix, Carthame Flos, Plantaginis Semen, Trichosamthis Fructus, Angelicae Sinensis Radix, Gentianae Radix; core prescription for Longdan Xiegan decoction and Trichosanthes red liquorice decoction. Professor Li Fa-zhi treatment of AIDS, herpes zoster and postherpetic neuralgia by clearing heat and removing dampness and activating blood circulation to.

  8. Wind tunnel study of natural ventilation of building integrated photovoltaics double skin façade

    Science.gov (United States)

    Hudişteanu, Sebastian Valeriu; Popovici, Cătălin George; Cherecheş, Nelu-Cristian

    2018-02-01

    The paper presents a wind tunnel experimental analysis of a small-scale building model (1:30). The objective of the study is to determine the wind influence on the ventilation of a double skin façade channel (DSF) and the cooling effect over integrated photovoltaic panels. The tests were achieved by conceiving and implementation of an experimental program using a wind tunnel with atmospheric boundary layer. The effect of the wind over the ventilation of the horizontal channels of double skin façades is evaluated for different incident velocities. The results are generalized for the average steady state values of the velocities analysed. The experimental results put in evidence the correlation between the reference wind velocity and the dynamics of the air movement inside the double skin façade. These values are used to determine the convective heat transfer and the cooling effect of the air streams inside the channel upon the integrated photovoltaic panels. The decrease of the photovoltaic panels temperature determines a raise of 11% in efficiency and power generated.

  9. Verification of FA2D Prediction Capability Using Fuel Assembly Benchmark

    International Nuclear Information System (INIS)

    Jecmenica, R.; Pevec, D.; Grgic, D.; Konjarek, D.

    2008-01-01

    FA2D is 2D transport collision probability code developed at Faculty of Electrical Engineering and Computing, University Zagreb. It is used for calculation of cross section data at fuel assembly level. Main objective of its development was capability to generate cross section data to be used for fuel management and safety analyses of PWR reactors. Till now formal verification of code predictions capability is not performed at fuel assembly level, but results of fuel management calculations obtained using FA2D generated cross sections for NPP Krsko and IRIS reactor are compared against Westinghouse calculations. Cross section data were used within NRC's PARCS code and satisfactory preliminary results were obtained. This paper presents results of calculations performed for Nuclear Fuel Industries, Ltd., benchmark using FA2D, and SCALE5 TRITON calculation sequence (based on discrete ordinates code NEWT). Nuclear Fuel Industries, Ltd., Japan, released LWR Next Generation Fuels Benchmark with the aim to verify prediction capability in nuclear design for extended burnup regions. We performed calculations for two different Benchmark problem geometries - UO 2 pin cell and UO 2 PWR fuel assembly. The results obtained with two mentioned 2D spectral codes are presented for burnup dependency of infinite multiplication factor, isotopic concentration of important materials and for local peaking factor vs. burnup (in case of fuel assembly calculation).(author)

  10. Recoveries of rat lymph FA after administration of specific structured C-13-TAG

    DEFF Research Database (Denmark)

    Vistisen, Bodil; Mu, Huiling; Høy, Carl-Erik

    2003-01-01

    of intragastrically administered L*L*L*, M*M*M*, ML*M, and ML*L* (where * = C-13-labeled FA) in rats. Lymph lipids were separated into lipid classes and analyzed by GC combustion isotope ratio MS. The recoveries of lymph TAG 18:2n-6 8 h after administration of L*L*L*, ML*M, and ML*L* were 38.6, 48.4, and 49...... rapid recovery of exogenous long-chain FA following administration of specific structured TAG compared with long-chain TAG was probably due to fast hydrolysis. The lymphatic recovery of 8:0 was 2.2% 24 h after administration of M*M*M*. This minor lymphatic recovery of exogenous 8:0 was probably due...... to low stimulation of chylomicron formation. These results demonstrate tendencies toward faster lymphatic recovery of long-chain FA after administration of specific structured TAG compared with long-chain TAG....

  11. Transport and fate of Herbaspirillum chlorophenolicum FA1 in saturated porous media

    Science.gov (United States)

    Li, X.; Xu, H.; Wu, J.

    2016-12-01

    For the bioremediation of contaminated groundwater, sufficient dispersal of functional microorganisms is one of the most important factors that determine the remediation efficiency. There are extensive studies on the transport of microbes in porous media, while most of them focus on pathogenic bacteria and little attention has been given toward functional bacteria that being used in bioremediation process. Therefore, accurate knowledge of the mechanisms that govern the transport and distribution of such bacteria in groundwater is needed to develop efficient treatment techniques. Herbaspirillum chlorophenolicum FA1, a pure bacterial strain capable of absorbing heavy metals and degrading polycyclic aromatic hydrocarbons (PAHs), was selected as the representative functional bacterium in this study. A series of batch and column experiments were conducted to investigate the transport and deposition behavior of strain FA1 in saturated porous media. The effects of physical (grain size), chemical (ionic strength, humic acid), and biological factors (living/dead cells) were studied in detail. In addition, numerical simulations of breakthrough curve (BTC) data were also performed for information gathering. Results of this study could advance our understanding of functional bacteria transport and help to develop successful bioremediation strategies. This work was financially supported by the National Natural Science Foundation of China -Xinjiang Project (U1503282), the National Natural Science Foundation of China (41030746, 41102148), and the Natural Science Foundation of Jiangsu Province (BK20151385). Keywords: Herbaspirillum chlorophenolicum FA1, bacteria, porous media, transport, modeling

  12. Fire protection concepts for Timber-Glass Composite façades

    Directory of Open Access Journals (Sweden)

    Schleicher Andreas

    2016-01-01

    The main objectives can be summarized as follows: Growth and densification in urban areas require the development of intelligent and resource-efficient building systems for “Smart Cities” of the future. By using timber-glass composites (TGC the primary energy demand of buildings can be reduced substantially. This research project examines the feasibility of applications of this new technology in multi-story and high-rise buildings. Critical aspects concerning fire protection such as flammability of timber elements, fire spread and failure of façade elements with bracing capacity will be analyzed. Different strategies will be developed in case studies and validated by structural analysis. Large scale mock ups of TGC façade elements will be checked on their suitability in fire tests. The findings of this research will lead to innovative fire safety concepts for building systems with TGC façades. Compliance with the high safety standards for multi-story buildings in urban areas like Vienna is one of the main objectives of this work. The adaptation of these fire safety concepts to the national standards of the neighboring countries will be continued subsequently. The gained knowledge should lead to further cooperation with companies for serial productions with TGC technology.

  13. Evaluation of dentoskeletal effects of Farmand functional appliance (Fa II on class II malocclusion

    Directory of Open Access Journals (Sweden)

    Yassaei S.

    2007-07-01

    Full Text Available Background and Aim: Functional appliances refer to a variety of removable or fixed appliances designed to alter the mandibular position both sagitally and vertically, resulting in orthodontic and orthopedic changes. Despite the long history of functional appliances, there is still much controversy related to their effectiveness and mode of action. The aim of this study was to evaluate dental and skeletal effects of Fa II in patients with class II malocclusion due to mandibular deficiency.Materials and Methods: In this before-after clinical trial, 35 patients with class II div I malocclusion were selected. These samples were under treatment with Fa II appliance for 11 months. The range of age of females was 10-13 years and males 11-14 years. Combination analysis was used to determine skeletal and dental effects. Paired t-test was used to compare the differences of mean value pre and post treatment. P<0.05 was considered as the level of significance. Results: There was significant difference between pre and post treatment in respect to posterior and anterior facial height, eruption of upper and lower posterior teeth, eruption of upper anterior teeth, mandibular body length, ANB angle, IMPA and 1 to SN. No significant difference was observed between pre and post treatment regarding facial growth.Conclusion: Treatment with Fa II functional appliance leads to significant alterations in dental and skeletal elements of craniofacial complex and improvement of dental and jaws relationship.

  14. Development and Characterization of a High Sensitivity Segmented Fast Neutron Spectrometer (FaNS-2).

    Science.gov (United States)

    Langford, T J; Beise, E J; Breuer, H; Heimbach, C R; Ji, G; Nico, J S

    2016-01-01

    We present the development of a segmented fast neutron spectrometer (FaNS-2) based upon plastic scintillator and 3 He proportional counters. It was designed to measure both the flux and spectrum of fast neutrons in the energy range of few MeV to 1 GeV. FaNS-2 utilizes capture-gated spectroscopy to identify neutron events and reject backgrounds. Neutrons deposit energy in the plastic scintillator before capturing on a 3 He nucleus in the proportional counters. Segmentation improves neutron energy reconstruction while the large volume of scintillator increases sensitivity to low neutron fluxes. A main goal of its design is to study comparatively low neutron fluxes, such as cosmogenic neutrons at the Earth's surface, in an underground environment, or from low-activity neutron sources. In this paper, we present details of its design and construction as well as its characterization with a calibrated 252 Cf source and monoenergetic neutron fields of 2.5 MeV and 14 MeV. Detected monoenergetic neutron spectra are unfolded using a Singular Value Decomposition method, demonstrating a 5% energy resolution at 14 MeV. Finally, we discuss plans for measuring the surface and underground cosmogenic neutron spectra with FaNS-2.

  15. Flight Test of the F/A-18 Active Aeroelastic Wing Airplane

    Science.gov (United States)

    Voracek, David

    2007-01-01

    A viewgraph presentation of flight tests performed on the F/A active aeroelastic wing airplane is shown. The topics include: 1) F/A-18 AAW Airplane; 2) F/A-18 AAW Control Surfaces; 3) Flight Test Background; 4) Roll Control Effectiveness Regions; 5) AAW Design Test Points; 6) AAW Phase I Test Maneuvers; 7) OBES Pitch Doublets; 8) OBES Roll Doublets; 9) AAW Aileron Flexibility; 10) Phase I - Lessons Learned; 11) Control Law Development and Verification & Validation Testing; 12) AAW Phase II RFCS Envelopes; 13) AAW 1-g Phase II Flight Test; 14) Region I - Subsonic 1-g Rolls; 15) Region I - Subsonic 1-g 360 Roll; 16) Region II - Supersonic 1-g Rolls; 17) Region II - Supersonic 1-g 360 Roll; 18) Region III - Subsonic 1-g Rolls; 19) Roll Axis HOS/LOS Comparison Region II - Supersonic (open-loop); 20) Roll Axis HOS/LOS Comparison Region II - Supersonic (closed-loop); 21) AAW Phase II Elevated-g Flight Test; 22) Region I - Subsonic 4-g RPO; and 23) Phase II - Lessons Learned

  16. TransiÃÃes de fase induzidas por altas pressÃes no molibdato de Ãtrio.

    OpenAIRE

    AbraÃo Cefas Torres Dias

    2011-01-01

    Neste trabalho investigamos as propriedades vibracionais do molibidato de Ãtrio hidratado e anidro em funÃÃo da pressÃo hidrostÃtica. A anÃlise dos modos vibracionais mostra que esse material experimenta uma transiÃÃo de fase da estrutura ortorrÃmbica para uma fase de mais baixa simetria para valores de pressÃo em torno de 0,3 GPa, provavelmente monoclÃnica, antes de se transformar em uma estrutura com alto grau de desordem a partir de 2,4 GPa. A transiÃÃo estrutural da fase ordenada para a f...

  17. Differential protection of Cry1Fa toxin against Spodoptera frugiperda larval gut proteases by cadherin orthologs correlates with increased synergism.

    Science.gov (United States)

    Rahman, Khalidur; Abdullah, Mohd Amir F; Ambati, Suresh; Taylor, Milton D; Adang, Michael J

    2012-01-01

    The Cry proteins produced by Bacillus thuringiensis (Bt) are the most widely used biopesticides effective against a range of crop pests and disease vectors. Like chemical pesticides, development of resistance is the primary threat to the long-term efficacy of Bt toxins. Recently discovered cadherin-based Bt Cry synergists showed the potential to augment resistance management by improving efficacy of Cry toxins. However, the mode of action of Bt Cry synergists is thus far unclear. Here we elucidate the mechanism of cadherin-based Cry toxin synergism utilizing two cadherin peptides, Spodoptera frugiperda Cad (SfCad) and Manduca sexta Cad (MsCad), which differentially enhance Cry1Fa toxicity to Spodoptera frugiperda neonates. We show that differential SfCad- and MsCad-mediated protection of Cry1Fa toxin in the Spodoptera frugiperda midgut correlates with differential Cry1Fa toxicity enhancement. Both peptides exhibited high affinity for Cry1Fa toxin and an increased rate of Cry1Fa-induced pore formation in S. frugiperda. However, only SfCad bound the S. frugiperda brush border membrane vesicle and more effectively prolonged the stability of Cry1Fa toxin in the gut, explaining higher Cry1Fa enhancement by this peptide. This study shows that cadherin fragments may enhance B. thuringiensis toxicity by at least two different mechanisms or a combination thereof: (i) protection of Cry toxin from protease degradation in the insect midgut and (ii) enhancement of pore-forming ability of Cry toxin.

  18. Effects of carbon dioxide level (PCO2) on the fibrinolytic activity (FA) of pulmonary artery endothelial cells (PAEC)

    International Nuclear Information System (INIS)

    Langleben, D.; Moroz, L.A.; Danes, D.

    1990-01-01

    Recovery from pulmonary thromboembolism depends on the rapidity and completeness of clot lysis. This involves endogenous fibrinolytic mechanisms, particularly the balance between plasminogen activators and inhibitors produced by endothelial cells. Hypocapnia is common in pulmonary embolism, however it is not known if endothelial fibrinolytic function is affected by PCO 2 . The authors therefore measured the FA in medium (MCDB-131, 0.5% albumin) conditioned for 20 hours in-vitro by exposure to confluent cultures of bovine proximal PAEC. During conditioning, cells were exposed to 5% CO 2 in air (PCO 2 - 36-40mm Hg, CONTROL), or various PCO 2 levels (30-55 mmHg, in air). FA of conditioned medium was determined by 125 I-fibrin solid phase assay, with addition of plasminogen (10 ug/ml). With PCO 2 levels ≤ 35 mmHg, FA in the conditioned medium was 5 to 18% higher than CONTROL FA. When PCO 2 was ≥ 45 mmHg, FA decreased 5 to 60% as compared to CONTROL FA. There was a significant negative linear relationship between PCO 2 and FA. Thus, PCO 2 level can affect PAEC mediated plasminogen activation. This finding may be relevant to in-vivo clearance of clots from pulmonary arteries

  19. Spread of smoke and heat along narrow air cavity in double-skin façade fires

    Directory of Open Access Journals (Sweden)

    Chow Lun Cheuk

    2014-01-01

    Full Text Available A scenario on double-skin façade fire was identified earlier for hazard assessment. A flashover room fire occurred next to the façade, broke the interior glass pane and spread to the façade cavity. As observed in experiments, hot gas moved up as a vertical channel flow for narrow façade cavity. Heat and smoke spread along the narrow air cavity of a double-skin façade will be studied in this paper. A simple mathematical model is developed from basic heat transfer theory for studying the vertical air temperature profiles of the hot gas flowing along the cavity. Assuming one-dimensional flow for hot gas moving up the façade cavity, conservation equations on mass and enthalpy were solved. Experimental results on two double-skin façade rigs of height 6 m and 15 m with narrow cavity depth were used to justify the results. A total of 11 tests were carried out. Correlation expressions between cavity air temperature and the height above ceiling of the fire room were derived.

  20. Measurement of FA and VitB{sub 12} in serum by TRFIA and its clinical application

    Energy Technology Data Exchange (ETDEWEB)

    Jinhong, Zhou; Huimin, Wang [Affiliated Hospital of Nantong Univ., Nantong (China). Dept. of Laboratory Medicine

    2006-03-15

    To investigate the correlation between diseases and the quantity of folic acid(FA) and vitamine B{sub 12} (VitB{sub 12}) in serum, the quantity of FA and VitB{sub 12} in serum was measured by TR- FIA. The results showed that the levels of FA and VitB{sub 12} in 68 controlled subjects were 20.13{+-}5.72 nmol/L and 240.45{+-}58.23 pmol/L respectively. The levels of FA and VitB{sub 12} in 6 patients with megaloblastic anemia, 26 with medium-terminal gestation femineity, 7 with liver cirrhosis, 10 with gastric ulcerand 31 with cerebral infarction were significant lower than those in the control group. The level of FA in 24 with malignant hematopathy and 57 with malignant tumor was significantly lower but VitB{sub 12} between the 31 patients with iron deficiency anemia and 12 with CAA and the control group. The amount of the FA in 9 patients with chronic atrophic gastritis and 42 blood donors were lower than that in the control. The determination of FA and VitB{sub 12} levels may be quite significant in the diagnosis, therapy and prognosis of diseases. Laboratories should establish the reference values which fit the locals specifically. (authors)

  1. Equilibrio entre fases para la aplicación de solventes verdes en tecnología de alimentos

    OpenAIRE

    Hernández, Elvis J.

    2010-01-01

    [ES]: En este trabajo se presentan los resultados obtenidos del estudio (experimental y teórico) del equilibrio entre fases de compuestos alimentarios y solventes verdes, aportando nuevos resultados a los fundamentos de los procesos de separación por contacto en equilibrio de la tecnología de alimentos. Se obtuvieron nuevos datos de equilibrio entre fases, aplicando métodos experimentales a altas presiones (equilibrio líquido – fluido supercrítico, para el disolvente dióxido de carbono) y ...

  2. Estudio del comportamiento de una sustancia de cambio de fase con condición de borde convectiva

    OpenAIRE

    Lozano, Ricardo; Villa Saravia, Luis Tadeo; Bouciguez, Angélica Carmen

    2016-01-01

    El proceso de fusión - solidificación, ha sido abordado con anterioridad, procurando soluciones a problemas de difusión con cambio de fase, cuando estando inicialmente solidas a la temperatura de fusión son sometidas a un flujo de calor por uno de sus laterales. Un flujo interesante es el convectivo, pues es la forma más realista de entrada o extracción de calor a la sustancia de cambio de fase. Dada esta condición de borde resulta interesante observar el comportamiento de la sustancia, cuand...

  3. Sensibilidade as catecolaminas dos atrios direitos das ratas : influencia das fases do ciclo estral e do "stress"

    OpenAIRE

    Monica Luiza Viegas Rodrigues

    1993-01-01

    Resumo: Os objetivos deste trabalho foram: analisar a sensibilidade ao efeito cronotrópico da isoprenalina, noradrenalina e adrenalina de átrios direitos isolados de ratas normais, em cada uma das fases do ciclo estral, ou após 50 minutos de natação, durante o estro ou o diestro; correlacionar as alterações de sensibilidade com as fases do ciclo estral e/ou com os níveis plasmáticos de corticosterona. Utilizamos ratas adultas, Wistar, normais, sedentárias, ou imediatamente após 50 min de nata...

  4. Morfogénesis de la fase sexual del helecho Arachniodes denticulata (Dryopteridaceae

    Directory of Open Access Journals (Sweden)

    Aniceto Mendoza

    1999-12-01

    Full Text Available Se describe la morfología de la espora y desarrollo de la fase sexual de Arachniodes denticulata (Sw. Ching. El material fue recolectado en los estados de Hidalgo, Oaxaca y Veracruz, México (una muestra por cada localidad. Las esporas fueron sembradas en medio de Thompson con agar (30 cajas. Sus esporas son monoletes con perina, elipsoidales, no clorofílicas. Su germinación es tipo Vittaria y su desarrollo protálico tipo Aspidium, el gametofito adulto es cordiforme-espatulado a cordiforme-reniforme; presentan tricomas marginales y superficiales, unicelulares, capitados; los rizoides no tienen cloroplastos; sus gametangios son del tipo común de los helechos leptosporangiados. Después de 200 días de haber sido sembradas las esporas, no se formaron esporofitos. Se concluye que A. denticulata comparte características comunes con A. aristata, A. assamica y con especies de los géneros Cyrtomium, Dryopteris, Polystichum, como son el tipo de germinación y desarrollo protálico, así como la presencia de tricomas unicelulares desde jóvenes protalos. Mientras que Didymochlaena truncatula difiere de las anteriores por presentar un patrón de desarrollo protálico tipo Adiantum y por la ausencia de tricomas en toda su fase sexual.Spore morphology and sexual fase development of Arachniodes denticulata (Sw. Ching are described from material collected in states of Hidalgo, Oaxaca and Veracruz, Mexico (one sample from each locality. The spores were sown in Thompson medium with agar (30 Petri dishes. The spores are monolete, with perine, ellipsoid in shape and non chlorophyllic. The germination is Vittaria-type and the prothallial development Aspidium-type; the gametophytes are cordiform-spatulate to cordiform-reniform in shape, with unicellular capitate trichome in margin and surface; rhizoids without chloroplasts; gametangia are the common type in leptosporangiate homosporous ferns. No sporophytes were observed after 200 days of culture. It is

  5. Barrido de frecuencia en coordenadas de fase Frequency scan on phase-coordinates

    Directory of Open Access Journals (Sweden)

    Ignacio Pérez Abril

    2012-02-01

    Full Text Available El análisis de redes eléctricas ha transitado de modelos en componentes de secuencia a modelos en coordenadas de fase. La formulación del barrido de frecuencia en coordenadas de fase, además de facilitar la modelación más precisa de las redes desequilibradas, permite especificar inyecciones armónicas de cualquier tipo: monofásicas o trifásicas de la secuencia deseada. Por lo que puede estudiarse el efecto de las cargas no lineales de acuerdo a sus características y conexión al circuito. El presente trabajo desarrolla el modelo en coordenadas de fase de una red eléctrica, considerando la representación de bancos de transformadores monofásicos de tres o dos transformadores, así como otros tipos de asimetrías que pueden encontrarse en los sistemas eléctricos de instalaciones industriales, de edificios comerciales o de servicio. El modelo desarrollado se prueba con un ejemplo sencillo de un sistema delta a cuatro hilos que permite destacar las posibilidades del modelo.The electric networks analysis has upgraded from the sequence components frame models to the phase- coordinates frame models. The formulation of the frequency scan method in a phase- coordinates frame, besides allowing for a more accurate modeling of unbalanced networks, allows the specification of harmonic injections of any type: single-phase or three-phase of the desired sequence. Therefore, it is possible to study the effect of the non-linear loads according to its features and connection to the circuit. This paper develops the phase-coordinates model of a distribution power system, considering the representation of three-phase transformer banks of three or two single-phase transformers, as well as other asymmetries that can be found in the electrical systems of industrial plants, commercial or service facilities. The frequency scan based on the presented model is tested with a simple example of a four-wire delta system that highlights the possibilities of the model

  6. Barrido de frecuencia en coordenadas de fase; Frequency scan on phase-coordinates

    Directory of Open Access Journals (Sweden)

    Ignacio Pérez Abril

    2014-04-01

    Full Text Available El análisis de redes eléctricas ha transitado de modelos en componentes de secuencia a modelos en coordenadas de fase. La formulación del barrido de frecuencia en coordenadas de fase, además de facilitar la modelación más precisa de las redes desequilibradas, permite especificar inyecciones armónicas de cualquier tipo: monofásicas o trifásicas de la secuencia deseada. Por lo que puede estudiarse el efecto de las cargas no lineales de acuerdo a sus características y conexión al circuito. El presente trabajo desarrolla el modelo en coordenadas de fase de una red eléctrica, considerando la representación de bancos de transformadores monofásicos de tres o dos transformadores, así como otros tipos de asimetrías que pueden encontrarse en los sistemas eléctricos de instalaciones industriales, de edificios comerciales o de servicio. El modelo desarrollado se prueba con un ejemplo sencillo de un sistema delta a cuatro hilos que permite destacar las posibilidades del modelo.  The electric networks analysis has upgraded from the sequence components frame models to the phase- coordinates frame models. The formulation of the frequency scan method in a phase- coordinates frame, besides allowing for a more accurate modeling of unbalanced networks, allows the specification of harmonic injections of any type: single-phase or three-phase of the desired sequence. Therefore, it is possible to study the effect of the non-linear loads according to its features and connection to the circuit. This paper develops the phase-coordinates model of a distribution power system, considering the representation of three-phase transformer banks of three or two single-phase transformers, as well as other asymmetries that can be found in the electrical systems of industrial plants, commercial or service facilities. The frequency scan based on the presented model is tested with a simple example of a four-wire delta system that highlights the possibilities of the

  7. Distribution of medium-chain FA in different lipid classes after administration of specific structured TAG in rats

    DEFF Research Database (Denmark)

    Mu, Huiling; Høy, Carl-Erik

    2002-01-01

    Structured TAG (STAG) containing medium-chain FA (MCFA) in the sn-1,3 positions and essential FA in the sn-2 position were synthesized by lipase-catalyzed acidolysis. In our previous studies we found that part of the MCFA from STAG could be absorbed in the small intestine; however, it was unclear...... how they were absorbed. In order to get a better understanding of the metabolism of STAG to improve future design and application of STAG, in the present study lymph lipids collected after feeding STAG were fractionated into different classes and the FA composition of each lipid class was studied...

  8. O uso do Aloe sp (aloe vera em feridas agudas e crônicas: revisão integrativa

    Directory of Open Access Journals (Sweden)

    Lucélia Terra Chini

    2017-01-01

    Full Text Available Objetivos: buscar evidencias disponibles en la literatura acerca del uso de Aloe sp (sábila en la cicatrización de heridas agudas y crónicas. Materiales y método: se trata de una revisión integradora realizada en las bases de datos LILACS, PubMed y Scopus, en el periodo de febrero a marzo del 2015. La búsqueda resultó en 178 publicaciones. Resultados: siete estudios constituyeron la revisión, los cuales involucraron personas con heridas de cesárea, heridas de episiotomía, quemaduras, área donadora de injerto, heridas posthemorroidectomía y heridas fisuarias anales crónicas. Se evidenció que la sábila promueve la cicatrización de heridas, además de disminuir el dolor en fisuras anales crónicas y quemaduras. Conclusiones: la sábila representa una nueva terapéutica en el tratamiento de heridas; sin embargo, las evidencias disponibles sobre su eficacia y seguridad son ineficientes para legitimar su uso en la cicatrización de heridas agudas y crónicas; por lo tanto, no se pueden generalizar.

  9. Abordaje transumbilical en pacientes pediátricos con sospecha de apendicitis aguda. Un serie de 424 pacientes

    Directory of Open Access Journals (Sweden)

    Luis Augusto Zárate Suárez

    2013-05-01

    Full Text Available Antecedentes: El tratamiento de la apendicitis aguda implica su extirpación; es frecuente la solicitud de cicatrices postquirúrgicas del mejor tamaño posible. Una de las estrategias disponibles es el abordaje transumbilical. Objetivos: Descubrir las características clínicas y los desenlaces operatorios de los pacientes pediátricos en quienes se realiza apendicectomía vía transumbilical. Metodología: Estudio prospectivo de 424 pacientes sucesivos en cuanto a los desenlaces operatorios a corto plazo. Resultados: El tiempo promedio de intervención quirúrgica fue de 22 minutos; 95,8% de los pacientes presentó evolución satisfactoria del postquirúrgico; 1,4% de los pacientes se reintervino para drenar un absceso intracavitario residual y 0,2% presentó infencción de sitio operatorio sin mas complicaciones. Conclusión: El abordaje transumbilical de la apendicitis es una alternativa minimamente invasiva para todos los estados de apendicitis aguda e implica disminución del tiempo de realización, menor estancia del postquirúrgico, menor incidencia de complicaciones y mayor conformidad con los resultados estéticos.

  10. Ciencia, tecnología y sociedad: reflexiones sobre el tratamiento antimicrobiano secuencial en la apendicitis aguda complicada

    Directory of Open Access Journals (Sweden)

    José Carlos Bueno Rodríguez

    Full Text Available Actualmente los estudios de Ciencia, Tecnología y Sociedad (CTS constituyen un importante espacio de trabajo en la política pública, la educación y la investigación. La introducción de nuevos procedimientos y tecnologías en la atención médica debe analizarse desde la perspectiva de los estudios de CTS porque requiere de un sustento científico-tecnológico y tiene que cumplir, entre otros, con los requisitos éticos de aplicabilidad a los seres humanos. La utilización secuencial de los antimicrobianos en el tratamiento postoperatorio de la apendicitis aguda complicada en los niños, constituye una modificación de la terapéutica comúnmente empleada en Cuba y en muchas instituciones de salud del mundo. El presente trabajo muestra una reflexión sobre los pilares científicos, tecnológicos y sociales que sustentan la aplicación de un nuevo protocolo de tratamiento con el uso secuencial de los antimicrobianos en los niños con apendicitis aguda complicada.

  11. Diabetes insipidus como manifestação inicial de leucemia mieloide aguda em paciente com monossomia do cromossomo 7

    Directory of Open Access Journals (Sweden)

    Amanda Dias Lima Morais

    2017-04-01

    Full Text Available O diabetes insipidus (DI central é uma síndrome caracterizada pela incapacidade de concentração urinária devido à deficiência do hormônio antidiurético. O envolvimento do sistema nervoso central é frequente nas leucemias, mas a ocorrência de DI é rara e confere pior prognóstico. A patogênese do DI na leucemia não é totalmente conhecida, mas a infiltração do eixo hipotálamo-hipofisário por células leucêmicas parece ser um fator responsável. O presente relato descreve o caso de um paciente que apresentou DI como primeira manifestação de leucemia mieloide aguda e que evoluiu com dificuldades de ajustes do sódio sérico, da poliúria e da reposição volêmica, necessitando de permanência prolongada em unidade de cuidados intensivos. Palavras-chave: diabetes insipidus; leucemia mieloide aguda; monossomia; cromossomo 7.

  12. Epiteliopatía pigmentaria placoide posterior multifocal aguda unilateral. A propósito de un caso

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    Ana Isabel Díaz Zapién

    2016-07-01

    Full Text Available Se presenta el caso de una mujer de 48 años de edad, que inicia su cuadro clínico con disminución súbita de agudeza visual acompañado de la presencia de un escotoma central en ojo derecho unilateral, sin otros síntomas acompañantes, antecedentes personales patológicos negados, 4 semanas después la paciente recupera visión llegando a un 20/20 sin la presencia del escotoma. La epiteliopatía pigmentaria placoide posterior multifocal aguda (EPPPMA es una patología inflamatoria coriorretiniana, que se presenta en adultos jóvenes, sanos, sin predominio por algún género, produciendo alteraciones visuales agudas, con hallazgos fundoscópicos característicos de lesiones placoides blanco-amarillentas a nivel del epitelio pigmentario de la retina. El diagnóstico se basa en los datos clínicos y la evolución complementado con la fluorangiografía, la mayoría de los casos con buen pronóstico visual, con una recuperación de la agudeza visual completa dentro de las primeras 3-6 semanas.

  13. Fases del kirchnerismo: de la ruptura a la afirmación particularista

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    Francisco J. Cantamutto

    2017-05-01

    Full Text Available El presente artículo analiza el kirchnerismo como proceso político populista. Utilizando la bibliografía especializada, es posible reconstruir la modificación en las alianzas políticas y sociales del gobierno, marcadas por el conflicto con la fracción agropecuaria del bloque en el poder en 2008. Este conflicto produjo un cambio de énfasis en la estrategia política del gobierno, que modificó su discurso y alianzas. Con base en ello se propone una periodización del proceso en dos etapas, donde se pasa de una fase ligada a la ruptura populista del orden institucional previo a una segunda donde se produce una afirmación particularista de la identidad kirchnerista. El artículo analiza en detalle los nuevos rasgos del orden político a partir de 2008.

  14. PRENDIMIENTO DE DOS TIPOS DE INJERTOS EN CACAO EN DISTINTAS FASES LUNARES, SIUNA 2014

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    Mario Reyes Martínez

    2016-05-01

    Full Text Available Sin duda, los productores saben de la influencia lunar y sobre el movimiento de la savia en las plantas en determinados momentos, debido a los conocimientos ancestrales y experiencias adquiridas. Sin embargo, en relación al prendimiento de injertos en cacao (Theobroma cacao, existen pocos estudios científicos que demuestren tales efectos. El objetivo principal del estudio fue comparar los efectos de las fases lunares en el prendimiento de dos tipos de injertos en cacao. Para ello se utilizó un diseño completamente al azar con arreglo bifactorial, con tres repeticiones por cada una de las fases y un universo de 576 plantas. La variable de medición únicamente fue el prendimiento de las plantas que se injertaron. Los datos fueron procesados en el programa Statistical Product and Service Solutions (SPSS versión 21 y se sometieron al análisis de varianza ANDEVA con un nivel de confianza del 95%. Los análisis revelan que existen diferencias significativas para las técnicas de injertación (p=0.011<0.05 y se obtuvo mayores prendimientos en los injertos de yema sobre los de bisel. Con respecto al efecto de las fases lunares sobre los dos tipos de injertos no se encontró evidencia estadística (p=0.950>0.05. En base al análisis combinado de varianza no existen diferencias significativas para la interacción fases lunares y técnicas de injertación puesto que (p=0.761>0.05. Summary There is no doubt the producers know of the moon influence and the sap movement in plants at certain moments, due to the ancestral knowledge and experiences gained. However, in relation to the root taking of grafts in cocoa (Theobroma cacao, there are few scientific studies that demonstrate such effects. The main objective of this study was to compare the effects of moon phases in the root taking of two types of grafts in cocoa. To do this we used a complete randomized design with bifactorial order, with three replays for each of the phases and a universe of 576

  15. Evaluation of Carbohydrate-Derived Fulvic Acid (CHD-FA) as a Topical Broad-Spectrum Antimicrobial for Drug-Resistant Wound Infections

    Science.gov (United States)

    2016-10-01

    the newly formulated CHD-FA-Zn. Our initial results demonstrated that CHD-FA-Zn reduced microbial burdens of susceptible and drug- resistant planktonic...wound-associated drug resistant bacteria and fungi. Rat models of wound infection (open, and burn model) will be established with healthy animals ...Establish MIC90s for CHD-FA with clinical isolates of major drug resistant pathogens Assess CHD-FA in animal models of wound infection for major

  16. Fístula bilio-duodenal pós colecistite aguda: Relato de caso

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    Marina Araújo Fonte Boa

    2016-12-01

    Full Text Available As fístulas biliares internas espontâneas são comunicações estabelecidas entre qualquer segmento da árvore biliar e dos órgãos abdominais. Elas constituem uma afecção rara apesar de compreender uma complicação da colecistite, patologia freqüente da prática cirúrgica. As fístulas bilioentericas ocorrem em 3-5% dos doentes com colelitíase, sendo 68% destas bilioduodenais. O objetivo desse manuscrito é relatar um caso de fístula bilioduodenal complicada com hemobilia e hemorragia digestiva, descrevendo a conduta adotada. Os dados foram coletados entre dezembro/2015 a abril/2016 através da analise de prontuário fornecido pelo Hospital Universitário Sul Fluminense (HUSF. Trata-se de um paciente masculino, 75 anos, atendido no HUSF-Vassouras/RJ com diagnóstico sindrômico de abdome agudo inflamatório por colecistite aguda, submetido a tratamento conservador para regressão da inflamação peri-colecística, diminuindo assim, o risco de lesões iatrogênicas da árvore biliar em posterior cirurgia. Evoluiu com melena, que foi investigada por endoscopia digestiva alta onde foi observada úlcera de bulbo duodenal com drenagem de secreção purulenta pela sua luz; e tomografia computadorizada de abdome que evidenciou presença de aerobilia indicando presença de fístula bileodigestiva. O tratamento conservador consistiu-se em antibioticoterapia e reposição volêmica, optado devido à remissão do quadro de colecistite após desobstrução pela fístula, devido à hemorragia que cessou espontaneamente e também pelo risco da realização do procedimento cirúrgico em paciente idoso com intensa resposta inflamatória sistêmica. Não é comum na literatura médica a ocorrência de fístulas biliodigestivas com sinais e sintomas hemorrágicos. O quadro clínico geralmente é inespecífico e frequentemente atrasado devido à falta de sinais e sintomas patognomônicos.

  17. Esofagitis necrotizante aguda: Una entidad inusual Acute esophageal necrosis: An unusual entity

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    Silvana E. Pramparo

    2010-12-01

    Full Text Available La esofagitis necrotizante aguda (ENA, también denominada esófago negro, es una rara enfermedad poco descripta en la literatura médica. Describimos el caso de un hombre de 80 años, con hemorragia digestiva alta quien desarrolló un esófago negro luego de un episodio de hipotensión. La necrosis fue confirmada histológicamente. Los pacientes se presentan con hematemesis y melena en más del 70% de los casos. Los hallazgos endoscópicos muestran una coloración negruzca de la mucosa esofágica. El diagnóstico se realiza con endoscopia y confirmación histológica. La mortalidad es alta (más del 50% aunque relacionada a las enfermedades de base del paciente. Por último, podemos decir que la sospecha es muy importante en el diagnóstico de ENA, particularmente en pacientes ancianos con enfermedades asociadas y evidencia de hemorragia digestiva alta. En este trabajo describimos las características clínicas, endoscópicas e histopatológicas de un paciente con ENA.Acute esophageal necrosis (AEN, also designated black esophagus, is a rare disorder that is poorly described in the medical literature. We present the case of an 80 years old man, with upper gastrointestinal bleeding who developed a black esophagus after hypotensive episodes. Necrosis was confirmed histologically. Hematemesis and melena are present in more than 70% of the cases. Endoscopic findings show black discoloration of the distal esophagus with proximal extension ending sharply at the gastroesophageal junction. Diagnosis is reached endoscopically with histological support. Mortality is high (up to 50% even though related to the patient's underlying condition. Finally, we may say that to keep in mind the posibility of AEN is a key factor in its diagnosis, particularly in older patients with associated morbidity and evidence of upper gastrointestinal bleeding. In the present report we describe the clinical, endoscopic and histophatological characteristics of a patient with a

  18. Intoxicación aguda por inhalación de Acrilato de Etilo, Lima 2002

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    Jeannette Ávila VM

    2005-10-01

    Full Text Available Objetivos: Describir las características clínico-epidemiológicas de los casos de intoxicación aguda por inhalación de acrilato de etilo, ocasionado por el manejo clandestino de un envase con restos de ésta sustancia, en una urbanización del distrito Comas, en Lima, Perú en noviembre del año 2002. Materiales y métodos: Estudio transversal analítico realizado en residentes y población del centro educativo aledaño a la zona del accidente. Se realizó una encuesta a todas las personas expuestas, se consideró como caso la presencia de cefalea, irritación ocular, nauseas, dolor abdominal y prurito intenso en el cuerpo. Se caracterizó el accidente en tiempo, espacio y persona. En el centro educativo se exploraron factores de exposición que favorecieron la presencia de intoxicados. Los datos fueron ingresados en Epi Info v 6.0 y analizados en STATA v.8.0 Resultados: Se encuestó 456 residentes y 326 personas en la escuela. La tasa de ataque general fue 21,9%, 46,9% en la escuela y 4,2% en viviendas. Los síntomas predominantes fueron cefalea 56%, irritación ocular 47%, dolor abdominal 42%. El 23% requirió hospitalización. El permanecer en pisos superiores de la escuela fue un factor de riesgo OR 4,54 (IC95% 2,66-7,84 y en el pabellón A OR 3,82 (IC95% 2,33-6,25. Conclusiones: Los síntomas predominantes fueron cefalea, irritación ocular y dolor abdominal. La cercanía a la zona de exposición del cilindro y la dispersión de los vapores tóxicos influyeron para afectar mayormente a la escuela y a aquellos que ocupaban aulas en pisos superiores y el pabellón A. La legislación peruana debe contemplar el problema del manejo clandestino de residuos peligrosos.

  19. Efectividad de la acupuntura en la crisis aguda de asma bronquial

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    María Teresa Paz Rodríguez

    2014-10-01

    Full Text Available Introducción: el asma bronquial es una enfermedad respiratoria con significativa prevalencia y una de las principales causas de ingreso hospitalario y la acupuntura una forma terapéutica de la Medicina Tradicional y Natural con múltiples indicaciones, dentro de ellas esta afección. Objetivo: determinar la evolución de los pacientes asmáticos persistentes moderados de ambos sexos antes y después del tratamiento con acupuntura en el servicio de urgencia en el Hospital General Docente Abel Santamaría Cuadrado de Pinar del Río. Material y método: se realizó un estudio de intervención, prospectivo, longitudinal, utilizando la acupuntura como modalidad terapéutica de la Medicina Tradicional China en pacientes que acudieron al cuerpo de guardia de Medicina Interna del Hospital General Docente "Abel Santamaría Cuadrado" de Pinar del Rio, en el período comprendido entre octubre-diciembre del 2013. El universo lo integraron todos los pacientes que acudieron a la consulta con crisis aguda de asma bronquial (223 y la muestra, 83 pacientes clasificados como asmáticos persistentes moderados utilizándose acupuntura en los puntos pulmón 7, vaso concepción 17 y vejiga 13 al grupo de estudio (41 pacientes y 42 con tratamiento convencional. Resultados: al tratar estos pacientes se ha evidenciado que el 78,4% de ellos mejoró por la aplicación de este método milenario. Ninguno presentó complicaciones y sólo 11 pacientes no mejoraron. Conclusiones: los pacientes respondieron de igual forma al tratamiento sin distinción de edad y sexo, demostrando este método ser eficiente, de fácil aplicación con aparición de menos reacciones adversas y además, económico.

  20. Rinovirus: Frecuencia en niños con infección respiratoria aguda, no internados

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    Débora N. Marcone

    2012-02-01

    Full Text Available Los métodos moleculares para diagnosticar rinovirus humanos (RVH han aumentado la sensibilidad de detección. Esto ha permitido documentar la asociación entre los RVH y las infecciones respiratorias agudas (IRA altas y bajas. La infección por RVH durante la infancia se asoció con posterior desarrollo de asma. Se estudió la frecuencia de RVH en 186 niños menores de 6 años ambulatorios con IRA (alta o baja, durante 2 años consecutivos (1/6/2008 - 31/5/2010. Se correlacionó la presencia de RVH con los antecedentes y características clínico-epidemiológicas. La detección de RVH se realizó con una RT-PCR en tiempo real que amplifica parte de la región 5' no codificante del genoma. Los virus respiratorios clásicos se estudiaron por inmunofluorescencia. En el 61% de los niños se detectó etiología viral. Las frecuencias fueron: RVH 27%, virus sincicial respiratorio (VSR 16%, influenza A y B 9%, parainfluenza 8%, metapneumovirus 7% y adenovirus 0.5%. Se observaron coinfecciones duales en 8 casos, siendo RVH el más frecuente (en 4 de ellos. Los RVH circularon durante todo el período estudiado, con picos en invierno y primavera. No se observaron diferencias clínico-epidemiológicas significativas entre pacientes con o sin RVH, excepto un mayor porcentaje de niños afebriles con RVH. Los RVH fueron los virus más detectados en niños ambulatorios, principalmente en menores de 2 años, los segundos virus asociados a bronquiolitis, luego del VSR, y detectados tres veces más en los niños expuestos a tabaquismo pasivo (OR: 2,91; p = 0.012 que en el resto. Fueron identificados como único agente en el 28% de las bronquiolitis.

  1. Intoxicación aguda por plaguicidas Acute poisoning from pesticides

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    Jaime Jesús Durán-Nah

    2000-02-01

    Full Text Available OBJETIVO: Describir la epidemiología de la intoxicación aguda por plaguicidas (IAP en el Hospital General O'Horán de Mérida, Yucatán, México. MATERIAL Y MÉTODOS: Se revisaron los expedientes de 33 pacientes ³ 13 años, tratados en una unidad de cuidados intensivos (UCI, entre 1994 y 1998. Se recopilaron variables demográficas y clínicas relevantes, y se aplicó estadística descriptiva. RESULTADOS: En la población estudiada predominó el sexo masculino (82% del medio rural (70%, y la edad media fue de 34 ± 15.8 años. El intento de suicidio fue causa frecuente de IAP (79%, y en 33% de los casos la intoxicación se produjo por la utilización de organofosforados. La mortalidad fue de 12%. CONCLUSIONES: La IAP fue baja entre los sujetos del medio rural, por lo que los resultados de este estudio parecen no reflejar la realidad del problema. Es importante añadir que los plaguicidas son utilizados con relativa frecuencia para el intento de suicidio.OBJECTIVE: To describe the epidemiologic pattern of acute pesticide poisoning (APP in a general hospital in Merida, Yucatan, Mexico. MATERIAL AND METHODS: From 1994 to 1998, 33 patients 13 years of age or older with diagnosis of APP were studied. Descriptive statistics were used to analyze information. RESULTS: Males were frequently affected (82%, specially those coming from rural areas (60%. The mean age of the group was 34 ± 15.8 years. In 79% of the cases, pesticides were used to commit suicide and 33% of poisoning cases were due to organophospate pesticides. The mortality rate was 12%. CONCLUSIONS: In this small sample, acute poisoning from pesticides in the agricultural setting may be underestimated, since it was less frequent than in the general population. APP was more commonly used by indigent people to commit suicide.

  2. Progressão de policitemia Vera para leucemia mieloide aguda

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    Marcelo Gil Cliquet

    2016-10-01

    Full Text Available Introdução: A Policitemia Vera (PV é um distúrbio clonal caracterizado pela hiperplasia de células hematopoiéticas, com acúmulo de eritrócitos, leucócitos e plaquetas. A mutação pontual JAK2 V617F parece ser o evento inicial da doença, presente em mais de 95% dos pacientes. Com a evolução da doença, há risco de progressão para leucemia mieloide aguda/ síndrome mielodisplásica (LMA/SMD. A transformação leucêmica pode ser espontânea em razão da idade, estágio da doença, estado imunológico ou associada com a terapia citoredutora, principalmente quando se usa alquilantes. Objetivo: Relatar o caso e um paciente com diagnóstico de PV há 19 anos com evolução para LMA há 8 meses. Métodos: As informações foram obtidas por meio de revisão do prontuário, entrevista com o paciente, registro fotográfico de exames e revisão da literatura. Relato: Paciente masculino, 81 anos, hipertenso, teve diagnóstico de PV em 1997, segundo critérios da OMS. No hemograma, concentração de hemograma(Hb de 18,2 g/dl, Heritrócito de 58,5%, leucócitos(leuc = 18.100/mm3 e plaquetas(plt = 64.800/mm3. Apresentava esplenomegalia a 4cm do rebordo costal esquerdo, fraqueza, cansaço e edema em membros inferiores. Paciente foi tratado com Hydroxiureia. O exame molecular de sangue periférico, em 2013, constatou a presença de mutação JAK2 (Val617Phe. Em Março de 2016, apresentou leuc de 86.400/mm3, plt de 152.000, Hb de 10,4g/dl. A imunofe- notipagem confirmou diagnóstico de LMA e o tratamento com Aracytin 20mg SC por sete dias foi iniciado. O paciente evoluiu com piora do estado geral, fraqueza, e infecção em membro inferior, vindo a falecer. Conclusão: Deve- se lembrar sobre a possibilidade da evolução da PV para LMA, mesmo em pacientes em tratamento por longos períodos em uso de hidroxiureia.

  3. Enfermedades diarreicas agudas en el niño: comportamiento de algunos factores de riesgo

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    Freddie Hernández Cisneros

    2000-01-01

    Full Text Available Se realizó un estudio de casos y controles, pareado 1:1, con el objetivo de conocer el comportamiento de algunos factores de riesgo de las enfermedades diarreicas agudas en el niño, en el Policlínico Comunitario Centro de Camagüey, durante 18 meses de trabajo. El grupo de casos estuvo representado por 89 niños de dicha área de salud egresados con ese diagnóstico, y el grupo control, por la misma cantidad de niños no egresados por ninguna enfermedad y de la misma área de salud. A ambos grupos se les aplicó una encuesta cuyos datos obtenidos se procesaron automatizadamente. Se encontraron como resultados más importantes un 97,67 % de niños menores de 1 año, la higiene doméstica no fue buena en el 80,9 % y la personal mala en el 73,03 %. Hubo destete precoz en el 65,17 % y hacinamiento en el 62,92 %, presentándose en el 45,9 % algún grado de desnutrición y el 37,08 % fueron bajo peso al nacer. El 32,58 % eran madres menores de 20 años y sólo el 15,73 % uso la lactancia materna pura. Se concluyó que todos los factores evaluados se comportaron como factores de riesgo, infiriéndose la importancia de la Educación para la Salud.A case-control study, matched 1:1, was conducted aimed at knowing the behaviour of some risk factors of acute diarrheal diseases in children at the Central Community Polyclinic of Camagüey, during 18 months. The case group was composed of 89 children from that health area that were discharged with that diagnosis, whereas the control group had the same number of children who were sound and lived in the same area. Both groups were surveyed and the data obtained were automatically processed. 97.6 % of the children were under 1, domestic hygiene was not good in 80.9 % and personal hygiene was also bad in 73.03 %. It was observed early weaning in 65.1 % and heaping in 62.92 %. Some degree of malnutrition was found in 15.9 % and 37.08 % were considered as low birth weight. 32.58 % were mothers under 20. Only 15

  4. Sindrome confusional agudo por abstinencia aguda de nicotina Delirium due to acute nicotine withdrawal

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    Manuel Klein

    2002-08-01

    Full Text Available El síndrome confusional agudo (SCA o delirium en pacientes hospitalizados es un problema frecuente y grave. Se caracteriza por síntomas de comienzo agudo y curso fluctuante con inatención, pensamiento desorganizado, y con distintos niveles de alteración de la conciencia.En la bibliografía consultada, el SCA como manifestación de un síndrome de abstinencia aguda nicotínica fue descripto en solo ocho casos. Presentamos el caso de un tabaquista grave que, internado por una reagudización de su enfermedad pulmonar obstructiva crónica (EPOC, presentó un cuadro de SCA al tercer día de abstinencia tabacal, cediendo los síntomas tras la administración de un parche de nicotina. Lo descripto sugiere que en pacientes internados que presentan SCA y agitación, con fuertes antecedentes de tabaquismo, un simple ensayo con un parche de nicotina puede ofrecer en pocas horas una notable respuesta terapéutica y a su vez un test confirmatorio. El reconocimiento del SCA como forma de presentación de la abstinencia nicotínica permitirá identificar casos habitualmente complejos en los que se podrá implementar una sencilla y eficaz alternativa terapéutica.Delirium or acute confusional state among hospitalized patients is a frequent and serious problem. It is characterized by acute onset symptoms, fluctuating course, impaired attention, unorganized thinking, and altered level of conciousness. Delirium, as a manifestation of acute nicotine withdrawal syndrome has been reported in the reviewed literature only in eight cases. We report the case of a heavy smoker admitted because of a reagudization of his chronic obstructive pulmonary disease. At the third day of nicotine abstinence, he developed delirium with a rapid improvement of his symptoms after treatment with a transdermal nicotine patch. This description suggests that in hospitalized heavy smokers who develop delirium with agitation, a simple trial with a nicotine patch can offer a dramatic

  5. Manejo de las infecciones respiratorias agudas (IRA en una comunidad kaqchiquel de Guatemala

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    Sáenz de Tejada Sandra

    1997-01-01

    Full Text Available Las infecciones respiratorias agudas (IRA figuran entre las principales causas de morbilidad y mortalidad infantiles en América Latina. En Guatemala, la neumonía es la primera causa de muerte en niños pequeños y ocasiona aproximadamente una tercera parte de las consultas ambulatorias a servicios pediátricos. Una buena proporción de estas muertes se deben a un manejo deficiente, atribuible a la falta de reconocimiento de los primeros signos de neumonía, a la presencia de barreras que impiden una búsqueda inmediata de atención, a la consulta a proveedores inapropiados o a recomendaciones terapéuticas inadecuadas. El propósito de esta breve investigación cualitativa fue estudiar las percepciones y los comportamientos de los habitantes de San Juan Comalapa, comunidad kaqchiquel en el altiplano central de Guatemala, en lo que respecta a las IRA. Se entrevistó a 32 madres en su domicilio con el fin de determinar cómo clasificaban las IRA y qué signos y síntomas las hacían buscar atención inmediata. Los resultados revelaron que las madres sabían reconocer la presencia de respiración rápida, pero no de tiraje respiratorio (dos signos importantes de neumonía. Cuando buscaban atención, solían acudir a médicos u otros proveedores en centros de salud y ocasionalmente en consultorios privados, pero la búsqueda raras veces era oportuna debido a la poca accesibilidad de los servicios y a la subestimación de la gravedad de los síntomas. Esta conducta podría modificarse por medio de una intervención educativa. Al final se hacen recomendaciones orientadas a mejorar la comunicación verbal entre los proveedores de atención de salud y las madres.

  6. Manejo de las infecciones respiratorias agudas (IRA en una comunidad kaqchiquel de Guatemala

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    Sandra Sáenz de Tejada

    1997-04-01

    Full Text Available Las infecciones respiratorias agudas (IRA figuran entre las principales causas de morbilidad y mortalidad infantiles en América Latina. En Guatemala, la neumonía es la primera causa de muerte en niños pequeños y ocasiona aproximadamente una tercera parte de las consultas ambulatorias a servicios pediátricos. Una buena proporción de estas muertes se deben a un manejo deficiente, atribuible a la falta de reconocimiento de los primeros signos de neumonía, a la presencia de barreras que impiden una búsqueda inmediata de atención, a la consulta a proveedores inapropiados o a recomendaciones terapéuticas inadecuadas. El propósito de esta breve investigación cualitativa fue estudiar las percepciones y los comportamientos de los habitantes de San Juan Comalapa, comunidad kaqchiquel en el altiplano central de Guatemala, en lo que respecta a las IRA. Se entrevistó a 32 madres en su domicilio con el fin de determinar cómo clasificaban las IRA y qué signos y síntomas las hacían buscar atención inmediata. Los resultados revelaron que las madres sabían reconocer la presencia de respiración rápida, pero no de tiraje respiratorio (dos signos importantes de neumonía. Cuando buscaban atención, solían acudir a médicos u otros proveedores en centros de salud y ocasionalmente en consultorios privados, pero la búsqueda raras veces era oportuna debido a la poca accesibilidad de los servicios y a la subestimación de la gravedad de los síntomas. Esta conducta podría modificarse por medio de una intervención educativa. Al final se hacen recomendaciones orientadas a mejorar la comunicación verbal entre los proveedores de atención de salud y las madres.

  7. Mortalidad por intoxicaciones agudas producidas con medicamentos: Cuba, 1995-1996

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    María Luisa González Valiente

    2000-04-01

    Full Text Available Se realizó un estudio descriptivo para determinar la incidencia de intoxicaciones agudas fatales medicamentosas en 1995 y 1996, y los principales factores de riesgo en la población cubana. Ocurrieron 314 defunciones para una tasa de 1,4 por 100 000 habitantes. En edades pediátricas el riesgo superior se encuentra en los menores de 1 a y en los adultos el riesgo aumenta al avanzar la edad, con una mayor afectación del sexo femenino. Las edades de mayor riesgo son a partir de 55 a en las mujeres y en los hombres después de 75 a. Los años de vida potencialmente perdidos fueron 7 430, con predominio de las mujeres (74 %. En los adultos predominaron las circunstancias voluntarias, en especial los suicidios con ingestión de psicofármacos; el diazepam y el fenobarbital se encuentran entre los más elegidos. En segundo término aparecen las reacciones adversas, producidas fundamentalmente por antibióticos, con predominio de las penicilinas. Por último, las circunstancias accidentales originadas por cardiotónicos. En los niños no existió diferencia estadística significativa en las diferentes circunstancias.We undertook a descriptive stuy to determine the incidence of fatal outcomes of acute drug poisoning in 1995 and 1996 and the main risk factors for the Cuban population. There were 314 deaths accounting for 1,4 death per 1000 pop. In pediatric ages, under 1 year-old infants are at the highest risk whereas risk for adults increases with age, being females the most affected ones. The most risky ages for women are from 55 years and over, and for men after 75 years of life. Potential years of life lost amounted to 7 430 with females predominating (74 %. Voluntary poisonings in adults prevailed spcially suicides from psychodrug-taking; diazepam and phenobarbital were the most used drugs for this end. Adverse drug effects was the second cause, which are mainly caused by antibiotics particularly penicilims. Lastly, accidental situations created

  8. AFSC/ABL: Origins of sockeye and chum salmon seized from the F/V Ying Fa

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Samples of chum (Oncorhynchus keta) and sockeye (O. nerka) salmon seized from the stateless fishing vessel Ying Fa were analyzed to determine their region of origin...

  9. Neurons in the monoaminergic nuclei of the rat and human central nervous system express FA1/dlk

    DEFF Research Database (Denmark)

    Jensen, Charlotte Harken; Meyer, M; Schrøder, Henrik Daa

    2001-01-01

    The gene DLK1 encodes a member of the epidermal growth factor (EGF) superfamily, delta-like (dlk). When exposed in vivo to the action of an unknown protease, this type 1 membrane protein generates a soluble peptide referred to as Fetal antigen 1 (FA1). By acting in juxtacrine as well as paracrine....../autocrine manners, both forms have been shown to be active in the differentiation/proliferation process of various cell types. In adults, FA1/dlk has been demonstrated mainly within (neuro) endocrine tissues. In this study we investigated the presence of FA1/dlk in other parts of the developing and adult rat...... and human CNS. Using immunocytochemistry and in situ hybridization we found that in both species FA1/dlk was expressed in neurons of the Edinger-Westphal's nucleus as well as in substantia nigra, ventral tegmental area (VTA), locus coeruleus and in certain parts of the raphe nuclei....

  10. Fiebre entérica en fase de fastigium: notas epicríticas acerca de un caso de autopsia

    OpenAIRE

    Salazar Morales, Miguel Fernando; Estrada Hernández, María del Rocío; Parraguirre Martínez, Sara

    2012-01-01

    La fiebre tifoidea es una enfermedad sistémica de etiología infecciosa ocasionada por el bacilo gramnegativo Salmonella typhi. Se presenta el caso de una mujer de 19 años quien comenzó con fiebre, dolor abdominal y diarrea; posteriormente cursó con insuficiencia hepática, necrosis tubular aguda, rabdomiolisis y trombocitopenia. Falleció a los 3 días del ingreso hospitalario. Los hallazgos de autopsia fueron: ulceración de placas de Peyer, inflamación y necrosis de ganglios linfáticos mesentér...

  11. Een analyse van de mogelijke gevolgen van de aanleg van IJburg tweede fase voor watervogels in de SBZ IJmeer

    NARCIS (Netherlands)

    Schekkerman, H.; Eerden, van M.E.; Rijn, van S.; Roos, M.

    2006-01-01

    De gemeente Amsterdam heeft vergevorderde plannen om in het IJmeer, grenzend aan het Vogelrichtlijngebied (SBZ, Natura 2000 gebied) IJmeer, de tweede fase van de wijk IJburg te realiseren. In dit rapport wordt (1) beschreven welke specifieke waarden van het IJmeer volgens de Vogelrichtlijn dienen te

  12. Studies on fluctuating asymmetry (FA for certain morphological traits in four species of the Drosophila bipectinata complex

    Directory of Open Access Journals (Sweden)

    Banerjee Parul

    2015-01-01

    Full Text Available Fluctuating asymmetry (FA is defined as subtle deviations from perfect bilateral symmetry, evident in differences between the right and the left sides of any given trait. It is a pattern of variation between sides and measures developmental instability. Differences in the level of FA may be used for comparing developmental precision among closely related species and thus may give an idea whether developmental stability was affected during the divergence and separation of populations into distinct species. Keeping this in view, FA was studied in four species of the Drosophila bipectinata complex i.e. D. bipectinata, D. parabipectinata, D. malerkotliana and D. pseudoananassae. In females of all the four species, FA values did not vary significantly for any of the traits considered. However, in case of males, they varied significantly for Wing length (WL and sex comb tooth number (SCTN. Also, while in females Composite fluctuating asymmetry (CFA did not exhibit significant variation, in males it was found to vary significantly across the four species. However, Bonferroni t-tests did not reveal any consistent difference in FA levels between any two species. The magnitude of FA was found to differ significantly among traits and CFA values were found to be higher for males than females in all the four species. Therefore, it may be concluded that the level of FA shows trait specific variations and males are more prone to developmental perturbations. However, the FA levels are more or less similar in all the four species of this complex. Thus, developmental precision remains nearly same in all the four species of this complex irrespective of the degree of evolutionary divergence reached.

  13. Recovery from sublethal damage during fractionated irradiation of human FaDu SCC

    International Nuclear Information System (INIS)

    Petersen, Cordula; Zips, Daniel; Krause, Mechthild; Voelkel, Wolfram; Thames, Howard D.; Baumann, Michael

    2005-01-01

    Background and purpose: The present study addresses whether recovery of sublethal damage in tumours may change during fractionated irradiation in FaDu human squamous cell carcinoma and whether such an effect might contribute to the pronounced time factor of fractionated irradiation previously found in this tumour. Patients and methods: FaDu tumours were transplanted s.c. into the right hind leg of NMRI nu/nu mice. Single doses or 2, 4, and 8 equal fractions in 3.5 days were applied in previously unirradiated tumours and after priming with 18 fractions of 3 Gy in 18 or 36 days. All irradiations were given under clamp hypoxic conditions. Experimental endpoints were tumour control dose 50% (TCD 50 ) and α/β values without and after priming. Results: Without priming TCD 50 increased with increasing number of fractions from 38.8 Gy (95% CI 35;45) after single dose irradiation to 54.0 Gy (42;57) after 8 fractions. No increase in TCD 50 when given in 1, 2, 4, or 8 fractions in 3.5 days was found after priming with 18 3-Gy fractions in 18 and 36 days. After priming with 18 fractions in 18 days TCD 50 remained constant at 25 Gy and after priming with 18 fractions in 36 days at 42 Gy. The α/β ratio without priming was 68 Gy (42;127). After fractionated irradiation with 18 3-Gy fractions in 18 and 36 days the α/β ratio increased to 317 Gy (38;∞) and to infinite, respectively. Conclusions: Our results indicate that clonogenic cells in FaDu tumours lose entirely their capacity to recover from sublethal radiation damage during fractionated irradiation. Therefore, an increased repair capacity as an explanation for the pronounced time factor of fractionated irradiation in this tumour can be ruled out

  14. Current status on advanced aqueous reprocessing process (next) in FaCT project

    International Nuclear Information System (INIS)

    Washiya, Tadahiro; Myochin, Munetaka; Koyama, Tomozo

    2009-01-01

    Japan Atomic Energy Agency (JAEA) launched the Fast Reactor Cycle Technology Development (FaCT) project in cooperation with the Japanese electric utilities in 2006. An integration of the advanced aqueous reprocessing concept and the simplified pelletizing fuel fabrication was selected as the most promising fuel cycle system. In order to accomplish the integration, R and D tasks were launched as FaCT Project in 2006 by Japanese joint team. The New Extraction System for TRU Recovery (NEXT) system is an advanced aqueous reprocessing concept which was based on the well established aqueous reprocessing for LWR spent fuel and newly applied processes such as uranium crystallization and extraction chromatography for MAs recovery. Main task of the NEXT process is to develop the TRU recovery process and equipments with high reliability, criticality safety, high durability and remote maintainability. In the FaCT project, all innovative technologies are planned to be developed within the next decade focusing on the future commercialization of FBR cycle systems. The judgment of the adoption of each innovative technology will be made by 2010 based on the results of R and Ds. The development of each technology is to be completed by around 2015. By the same time, it is scheduled to present the conceptual design of commercial and demonstrative fast reactor cycle facilities. The six items (Disassembling and shearing, Fuel dissolution, Uranium Crystallization, Single cycle co-extraction of U, Pu and Np, MA recovery by extraction chromatography and Waste treatment) have been identified as the issues to be developed corresponding to each process step. Current R and D status and prospects of this system until around 2015 is reported. (author)

  15. Accident Testing of High Temperature Reactor Fuel Elements with the KueFA Device

    International Nuclear Information System (INIS)

    Seeger, O.; Laurie, M.; Bottomley, P.D.W.; Ferreira-Teixeira, A.E.; Van Winckel, S.; Rondinella, V.V.; Allelein, H.J.

    2013-06-01

    The High Temperature Reactor (HTR) is characterised by an advanced design with passive safety features. Fuel elements are constituted by a graphite matrix containing sub-mm-sized fuel particles with Tri-Isotropic (TRISO) coating, designed to provide high fission product retention. During a loss of coolant accident scenario in a HTR the maximum temperature is foreseen to be in the range of 1600-1650 deg. C, remaining well below the melting point of the fuel. The Cold Finger Apparatus (KueFA) is used to observe the combined effects of Depressurization and Loss of Forced Circulation (DLOFC) accident scenarios on HTR fuel. Originally designed at the Forschungszentrum Juelich (FZJ), an adapted KueFA operates on irradiated fuel in hot cell at JRC-ITU. A fuel pebble is heated in He atmosphere for several hundred hours, mimicking accident temperatures up to 1800 deg. C and realistic temperature transients. Non-gaseous volatile fission products released from the fuel condense on a water cooled stainless steel plate dubbed 'Cold Finger'. Exchanging plates frequently during the experiment and analysing plate deposits by means of HPGe gamma spectroscopy allows a reconstruction of the fission product release as a function of time and temperature. In order to achieve a good quantification of the release, a careful calibration of the setup is mandatory. An especially tailored collimator was designed to perform plate scanning with high spatial resolution, thus yielding information about the fission product distribution on the condensation plates. The analysis of condensation plates from recent KueFA tests shows that fission product release quantification is possible at high and low activity levels. Chemical dissolution has been performed for some condensation plates in order to assess beta nuclides of interest such as 90 Sr and possibly 129 I using an Inductively Coupled Plasma - Mass Spectrometer (ICP-MS) and to cross check the HPGe gamma spectroscopy measurements

  16. Birth order and recalled childhood gender nonconformity in Samoan men and fa'afafine.

    Science.gov (United States)

    Semenyna, Scott W; VanderLaan, Doug P; Vasey, Paul L

    2017-04-01

    Having a greater than average number of older biological brothers is a robust correlate of male androphilia (i.e., sexual attraction and arousal to adult males). Previous investigations have sought to understand whether this fraternal birth order (FBO) effect is also systematically related to recalled indicators of childhood gender nonconformity (CGN). However, these investigations have relied on data from low-fertility Western populations in which expressions of femininity in male children are routinely stigmatized and consequently, suppressed. The present study examined the FBO effect (among other sibship characteristics) and recalled indicators of CGN in Samoa, a high-fertility population, whose members are relatively tolerant of male femininity. Indeed, Samoans identify feminine androphilic males as belonging to an alternative gender category, known locally as fa'afafine. The present study compared the sibship characteristics of 231 fa'afafine and 231 opposite-sex attracted men from Samoa, as well as how these characteristics related to recalled CGN. Results replicated the well-established FBO effect for predicting male sexual orientation, with each older brother increasing the odds of being androphilic by 21%. However, no relationship was found between the number of older brothers (or other siblings) a participant had and their recalled CGN. Although fa'afafine reported significantly more CGN than Samoan men, CGN did not mediate the FBO effect, nor did the FBO effect and CGN interact to predict male sexual orientation. These findings are consistent with previous studies suggesting that the FBO effect is associated with male sexual orientation, but not childhood female-typical gender expression among androphilic males. © 2017 Wiley Periodicals, Inc.

  17. Caracterización del comportamiento clínico-quirúrgico de la pancreatitis aguda en una unidad hospitalaria de Pinar del Río

    Directory of Open Access Journals (Sweden)

    Eduardo Rogelio García Noguera

    2015-08-01

    Full Text Available Introducción: la pancreatitis aguda es una enfermedad que produce diversos grados de inflamación en el órgano y puede llegar hasta la necrosis glandular. Objetivo: caracterizar el comportamiento clínico-quirúrgico en los pacientes con pancreatitis aguda en el Hospital General Docente "Abel Santamaría Cuadrado" de Pinar del Rio, en el periodo de 2009-2012. Material y método: se realizó una investigación observacional, descriptiva, longitudinal, retrospectiva, en pacientes con diagnóstico de pancreatitis aguda, ingresados en el Hospital General Docente "Abel Santamaría Cuadrado", de Pinar del Río, entre el 2009 y el 2012. Resultados: el 53,3% de los pacientes ingresó en el Servicio de Cirugía y el resto en la Unidad de Cuidados Intensivos. El 77,8% de los pacientes fueron intervenidos quirúrgicamente antes de transcurrir 48 horas desde el ingreso. Existió un predominio notable de enfermos complicados que ingresaron en las salas de cirugía, prevaleciendo en estos las complicaciones agudas o sistémicas. En los pacientes operados la mortalidad se elevó considerablemente un 42,1%. Conclusiones: para llevar a cabo una conducta adecuada en los pacientes ingresados con pancreatitis aguda, y de esta manera reducir las complicaciones y fallecimiento por esta causa, se deben ingresar desde el inicio en una sala de cuidados intensivos; además de incrementar el empleo de investigaciones como la TAC abdominal y disminuir los casos intervenidos quirúrgicamente.

  18. Suspected acute toxoplasmosis in pregnant women Suspeita de toxoplasmose aguda em gestantes

    Directory of Open Access Journals (Sweden)

    Marcela Peres Castilho-Pelloso

    2007-02-01

    Full Text Available OBJECTIVE: To determine the prevalence of reagent serology for suspected acute toxoplasmosis in pregnant women and to describe clinical, laboratory and therapeutic profiles of mothers and their children. METHODS: A retrospective study was conducted with IgM-anti-Toxoplasma gondii-reagent pregnant women and their children who attended the public health system in the state of Paraná, Southern Brazil, from January 2001 to December 2003. Information were obtained from clinical, laboratory (ELISA IgM/IgG and ultrasonographic data and from interviews with the mothers. To test the homogeneity of the IgM indices in relation to the treatment used, the Pearson's Chi-square test was applied. Comparisons were considered significant at a 5% level. RESULTS: Two hundred and ninety (1.0% cases of suspected IgM-reagent infection were documented, with a prevalence of 10.7 IgM-reagent women per 1,000 births. Prenatal care started within the first 12 weeks for 214/290; 146/204 were asymptomatic. Frequent complaints included headaches, visual disturbance and myalgia. Ultrasonography revealed abnormalities in 13 of 204 pregnancies. Chemoprophylaxis was administered to 112/227; a single ELISA test supported most decisions to begin treatment. Pregnant women with IgM indices =2.000 tended to be treated more often. Among exposed children, 44/208 were serologically followed up and all were IgG-reagent, and three IgM-reagent cases showed clinical symptoms. CONCLUSIONS: The existence of pregnant women with laboratorially suspected acute toxoplasmosis who were not properly followed up, and of fetuses that were not adequately monitored, shows that basic aspects of the prenatal care are not being systematically observed. There is need of implementing a surveillance system of pregnant women and their children exposed to T. gondii.OBJETIVO: Determinar a prevalência de gestantes com sorologia reagente suspeita de toxoplasmose aguda e descrever as variáveis maternas e do

  19. Aspectos nutricionais na lesão renal aguda Nutritional aspects in acute kidney injury

    Directory of Open Access Journals (Sweden)

    Marina Nogueira Berbel

    2011-10-01

    Full Text Available A avaliação nutricional é ferramenta indispensável para a monitoração e acompanhamento clínico do paciente com lesão renal aguda (LRA. A perda aguda da função renal interfere no metabolismo de todos os macronutrientes, propiciando situações pró-inflamatórias, pró-oxidativas e de hipercatabolismo. As principais alterações nutricionais no paciente com LRA são hipercatabolismo, hiperglicemia e hipertrigliceridemia, que, somadas às contribuições da doença de base, complicações e necessidade de terapia renal substitutiva, podem interferir na depleção nutricional do paciente. A desnutrição em pacientes com LRA está associada a maior incidência de complicações, maior tempo de internação e maior mortalidade. Entretanto, existem poucos estudos na literatura avaliando o estado nutricional de pacientes com LRA. Parâmetros antropométricos como índice de massa corporal, circunferência do braço e pregas cutâneas são de difícil interpretação, devido à alteração no estado de hidratação desses pacientes. Os parâmetros bioquímicos geralmente utilizados na rotina clínica também sofrem influência de fatores não nutricionais, como prejuízo da função hepática e estado inflamatório. Embora não existam dados prospectivos sobre o comportamento dos marcadores nutricionais, alguns autores conseguiram demonstrar associações de alguns parâmetros com desfecho clínico. A utilização de marcadores como albumina, colesterol, pré-albumina, IGF-1, aplicação da avaliação subjetiva global e cálculo do balanço nitrogenado parecem ser úteis como parâmetros de triagem para pior prognóstico e maior mortalidade em pacientes com LRA. Em pacientes com LRA em terapia renal substitutiva, uma oferta calórica em torno de 25 a 30 kcal/kg e oferta mínima de 1,5 g/kg/dia de proteínas é recomendada a fim de minimizar o catabolismo proteico e prevenir complicações metabólicas.Nutritional assessment is an

  20. Objective and subjective evaluation of façade sound insulation

    DEFF Research Database (Denmark)

    Ordoñez, Rodrigo Pizarro; Visentin, Chiara; Markovic, Milos

    2013-01-01

    by filtering recordings of traffic noise with the frequency response of sound insulation measurements. The measurements were performed in typical Italian buildings in accordance with the ISO 140-5 standard. The objectives of the present paper are to compare the subjective evaluations obtained with the two......Façade insulation of several different construction types were subjectively evaluated using two psychoacoustic methods: paired comparisons using a two alternative forced choice (2-AFC) paradigm and direct scaling using a visual analogue scale (VAS). The stimuli used in the evaluations were obtained...

  1. Transparent Façade Panel Typologies Based on Recyclable Polymer Materials

    Directory of Open Access Journals (Sweden)

    Harry Giles

    2012-11-01

    Full Text Available Buildings are large consumers of energy. In the United States of America; they constitute over 33% of the total annual energy consumption, produce 35% of the total carbon dioxide emissions and attribute 40% of landfill wastes. The building industry is also a large consumer of non-renewable materials and this trend has escalated dramatically over the past century. It is essential that we find ways to save on energy consumption through the use of solar energy, improved thermal insulation, and alternative efficient glazed façade systems. In this paper, we demonstrate how alternative typologies of transparent and translucent load-bearing façade systems based on biocomposite and recyclable materials, are structurally and thermally efficient at the same time they contribute towards reduced pollutant emissions and non-renewable material uses.Composite insulated panel systems are used extensively in the engineering and building industry, owing to their structural and thermal efficiency. However, these systems are generally opaque and offer little flexibility in building applications. As an alternative, we demonstrate how building products comprised of hybrid material typologie scan be made to perform efficiently as load-bearing façade systems that substitute for current glazing systems with adequate thermal and structural performance, which also possess good light transmission characteristics and integral shading capability. The materials are configured to work as composite panel systems made from a combination of biocomposite and recyclable polymer materials. These materials are environmentally sustainable, because they either originate from naturally grown renewable resources or are recyclable. Our research program includes the design and development of prototype panel systems; the evaluation of structural and thermal performance, together with their role in reducing energy consumption and pollution emission through life cycle analysis. The paper

  2. Poly(3-Hydroxybutyrate) Synthesis Genes in Azotobacter sp. Strain FA8

    OpenAIRE

    Pettinari, M. Julia; Vázquez, Gustavo J.; Silberschmidt, Daniel; Rehm, Bernd; Steinbüchel, Alexander; Méndez, Beatriz S.

    2001-01-01

    Genes responsible for the synthesis of poly(3-hydroxybutyrate) (PHB) in Azotobacter sp. FA8 were cloned and analyzed. A PHB polymerase gene (phbC) was found downstream from genes coding for β-ketothiolase (phbA) and acetoacetyl-coenzyme A reductase (phbB). A PHB synthase mutant was obtained by gene inactivation and used for genetic studies. The phbC gene from this strain was introduced into Ralstonia eutropha PHB-4 (phbC-negative mutant), and the recombinant accumulated PHB when either glucos...

  3. Cercetări experimentale privind comportarea sistemelor pentru faţade, expuse la acţiunea focului

    Directory of Open Access Journals (Sweden)

    Ştefania Rădulescu

    2010-12-01

    Full Text Available Visually, it is often the goal of any architecture to define a personality or individual character through the design of the façade. This face or skin, wrapped to the structural frame beneath, is often key to an architect's desire to evoke our emotions, instilling a sense of grandeur as if each new building were an artist's sculpture. In recent decades the desire for taller structures and, particularly, those that are competing for recognition to be among the tallest, if not the world's tallest, is reason to review the fire safety issues related to façade or curtain wall design. Additionally, due to the creativity of architects, new and unique façade designs are continually appearing. The risk of fire spread through articulated elements of the façade or vertically around the façade via the mechanism of flame leap, poses new concerns for the newest class of super highrise structures. Our understanding of fire and its mechanisms of spread in buildings no longer eludes us, however, the risks of fire spread related to super high-rise buildings and the façades that define their character has not been well examined. Current code practices recognize the successful record of fully sprinkler protected high-rise buildings and only require that the void space between the curtain wall and the floor slab be resistive to fire spread using a perimeter fire barrier system.

  4. Studies on watermelon somatic cell mutant of resistance to fusaric acid (FA) by low energy Ar+ ion beam irradiation

    International Nuclear Information System (INIS)

    Wang Haobo; Gu Yunhong; Cheng Guowang; Yu Zengliang

    2003-01-01

    Three kinds of watermelon seeds irradiated by Ar + ion beam (25 keV, 6.24 x 10 16 ions/cm 2 ) were inoculated in MS medium with 15 mg/L FA. Cotyledons from the sterile seedling as explants were inoculated in MS +BA 2.0 mg/L + FA 15 mg/L. And the adventitious shoots of resistance to FA were cultured in MS + NAA 0.2 mg/L + FA 15 mg/L. The results showed that both the irradiation of Ar + and FA affected the germination rate and seedling of watermelon line 3-27 and YH-5, and the joint effect of Ar + and FA showed an enhanced restraint. The adventitious shoot and rootage induction rate from the seeds irradiated by Ar + were respectively bigger than the unirradiated seeds in 3-27 and YH-5. The increasing ranges were different between two watermelon lines and between the shoot and rootage induction rates

  5. Vesicular stomatitis virus (indiana 2 serotype as experimental model to study acute encephalitis – morphological features Vírus da estomatite vesicular (sorotipo indiana 2 como modelo experimental para o estudo de encefalite aguda – aspectos morfológicos

    Directory of Open Access Journals (Sweden)

    Florêncio Figueiredo Cavalcanti Neto

    2003-10-01

    ículos cerebrais, multiplicando-se em células do epêndima e em neurônios, além de utilizar o transporte retrógado e anterógrado. Constatamos que devido à facilidade de manipulação do vírus, este modelo experimental tem sido utilizado em inúmeros trabalhos de pesquisa em diversas áreas. Se por um lado, os relatos sobre a patogenia da infecção são numerosos, por outro lado, ainda existem muitas lacunas que envolvem, por exemplo, aspectos sobre a transmissão do vírus, a recuperação dos animais infectados e a participação de células gliais durante a fase aguda e a fase de recuperação dos animais.  

  6. Caries dental aguda del primer molar permanente en niños de 12 años

    Directory of Open Access Journals (Sweden)

    Daniel Enrique Reyes Romagosa

    Full Text Available Introducción: el primer molar permanente es considerado la llave de la oclusión dentaria, la presencia de caries en éste es elevada, lo que dificulta el logro de las metas trazadas por organizaciones de salud a nivel mundial en este grupo de edad. Objetivo: determinar el comportamiento de la caries dental aguda en primer molar permanente en una población de 12 años de edad atendida en la Clínica Estomatológica Santa Cruz de la Parroquia Goaigoaza. Métodos: se realizó un estudio descriptivo transversal en la Clínica Estomatológica Santa Cruz. Parroquia Goaigoaza, municipio Puerto Cabello, estado Carabobo, en el período comprendido entre abril del 2009 a abril 2010. Se seleccionaron 97 pacientes de 12 años de edad los que constituyeron el universo y la muestra. Acudieron a la consulta por dolor debido a la presencia de caries dental aguda. Se registraron las variables: edad, sexo, grado clínico de la caries dental, estímulos externos que provocaron dolor, la cara dental y la arcada dentaria más afectadas. La información fue recogida mediante interrogatorio y examen clínico. Resultados: el sexo masculino representó el 63,9 %. La caries dental de 3er grado estuvo presente en un 68 %. Los estímulos externos que provocaron dolor fueron: el frío presente en 75,2 % y los alimentos dulces en 69,1 % en ambos sexos. El primer molar inferior derecho resultó más afectado (46,4 % que el izquierdo (36,1 %, así como la arcada dentaria inferior (25,8 % y la cara oclusal (64,9 %. Conclusiones: predominaron el sexo masculino y la caries dental aguda de 3er grado. El frío y los alimentos dulces fueron los estímulos externos más frecuentes. Los más afectados resultaron el primer molar inferior derecho, la cara oclusal y la arcada dentaria inferior.

  7. Estrategia de atención de niños hospitalizados por infecciones respiratorias agudas bajas

    Directory of Open Access Journals (Sweden)

    Ana M Ferrari

    2002-06-01

    Full Text Available OBJETIVO: Mejorar la calidad de la atención hospitalaria de los niños con infecciones respiratorias agudas bajas, aumentar los conocimientos sobre esa patología y mejorar la eficiencia en el uso de los recursos asistenciales, por medio de una estrategia que se denominó Plan de Invierno.MÉTODOS: La estrategia se basó en la utilización de protocolos de diagnóstico y tratamiento, internación por cuidados progresivos y por enfermedad, adecuación de los recursos asistenciales y creación de un sistema de registro permanente, informatizado. Se incorporó la investigación sistemática de la etiología viral para racionalizar el uso de la medicación y reducir las infecciones intrahospitalarias. RESULTADOS: Durante la aplicación del Plan (19/V-19/IX/99 ingresaron 3.317 niños; 1.347 (40.61% presentaban infecciones respiratorias agudas bajas. Se captaron 1.096 (81%, de los cuales 71% eran menores de un año. Predominaron las infecciones respiratorias virales (68%. Los criterios de ingreso fueron saturación de oxígeno <95%, polipnea, tiraje o derrame pleural en el 92.4% de los niños. La magnitud de la demanda impidió que las pautas de aislamiento individual o en grupo se cumplieran en todos los casos. El uso de la medicación se ajustó a lo recomendado en un elevado porcentaje: no recibieron antibióticos 73% de las bronquiolitis ni 72% de las neumonías virales, y 96% de las neumonias bacterianas los recibieron según pauta; se redujo el uso de broncodilatadores y de corticoides. El gasto en medicamentos disminuyó fundamentalmente en el grupo de los corticoides y tuvo el mayor impacto en el costo por día/cama de antibióticos. CONCLUSIONES: Disminuir la morbimortalidad por infecciones respiratorias agudas bajas requiere continuar mejorando la calidad de la atención hospitalaria y fortalecer los programas de promoción de salud y de control de las enfermedades prevalentes, en el primer nivel de atención.

  8. Estrategia de atención de niños hospitalizados por infecciones respiratorias agudas bajas

    Directory of Open Access Journals (Sweden)

    Ferrari Ana M

    2002-01-01

    Full Text Available OBJETIVO: Mejorar la calidad de la atención hospitalaria de los niños con infecciones respiratorias agudas bajas, aumentar los conocimientos sobre esa patología y mejorar la eficiencia en el uso de los recursos asistenciales, por medio de una estrategia que se denominó Plan de Invierno.MÉTODOS: La estrategia se basó en la utilización de protocolos de diagnóstico y tratamiento, internación por cuidados progresivos y por enfermedad, adecuación de los recursos asistenciales y creación de un sistema de registro permanente, informatizado. Se incorporó la investigación sistemática de la etiología viral para racionalizar el uso de la medicación y reducir las infecciones intrahospitalarias. RESULTADOS: Durante la aplicación del Plan (19/V-19/IX/99 ingresaron 3.317 niños; 1.347 (40.61% presentaban infecciones respiratorias agudas bajas. Se captaron 1.096 (81%, de los cuales 71% eran menores de un año. Predominaron las infecciones respiratorias virales (68%. Los criterios de ingreso fueron saturación de oxígeno <95%, polipnea, tiraje o derrame pleural en el 92.4% de los niños. La magnitud de la demanda impidió que las pautas de aislamiento individual o en grupo se cumplieran en todos los casos. El uso de la medicación se ajustó a lo recomendado en un elevado porcentaje: no recibieron antibióticos 73% de las bronquiolitis ni 72% de las neumonías virales, y 96% de las neumonias bacterianas los recibieron según pauta; se redujo el uso de broncodilatadores y de corticoides. El gasto en medicamentos disminuyó fundamentalmente en el grupo de los corticoides y tuvo el mayor impacto en el costo por día/cama de antibióticos. CONCLUSIONES: Disminuir la morbimortalidad por infecciones respiratorias agudas bajas requiere continuar mejorando la calidad de la atención hospitalaria y fortalecer los programas de promoción de salud y de control de las enfermedades prevalentes, en el primer nivel de atención.

  9. Design of MiSolFA Hard X-Ray Imager

    Science.gov (United States)

    Lastufka, Erica; Casadei, Diego

    2017-08-01

    Advances in the study of coronal electron-accelerating regions have so far been limited by the dynamic range of X-ray instruments. A quick and economical alternative to desirable focusing optics technology is stereo observation. The micro-satellite MiSolFA (Micro Solar-Flare Apparatus) is designed both as a stand-alone X-ray imaging spectrometer and a complement to the Spectrometer/Telescope for Imaging X-rays (STIX) mission. These instruments will be the first pair of cross-calibrated X-ray imaging spectrometers to look at solar flares from very different points of view. MiSolFA will achieve indirect imaging between 10 and 60 keV and provide spectroscopy up to 100 keV, equipped with grids producing moiré patterns in a similar way to STIX. New manufacturing techniques produce gold gratings on a graphite or silicon substrate, with periods ranging from 15 to 225 micrometers, separated by a distance of 15.47 cm, to achieve a spatial resolutions from 10" to 60" (as compared to RHESSI's separation of 150 cm and 1" resolution). We present the progress of the imager design, the performance of the first prototypes, and reach out to the community for further scientific objectives to consider in optimizing the final design.

  10. The Arabic Hyperbolic Pattern 'Fa??al' in Two Recent Translations of the Qur'an

    Directory of Open Access Journals (Sweden)

    Amr M. El-Zawawy

    2014-06-01

    Full Text Available The present study addresses the problem of rendering the فعال'fa??al' hyperbolic pattern into English in two recent translations of the Qur'an. Due to the variety of Qur'an translations and the large amount of hyperbolic forms of Arabic verbs recorded in the Qur'an, only two translations of the Qur'an are consulted and analyzed: these two translations, namely Saheeh International Translation (1997 and Prof. Abdel-Haleem's (2004, are distinguished by the fact that they are recent and well-received. Moreover, the investigation of hyperbolic forms is confined to the Arabic formفعال    'fa??al'. The study reveals that the Saheeh translator has applied morphological shifting in many examples while Abdel-Haleem's translation exhibits a considerable amount of syntactic transposition, coupled with paraphrasing. The test of accuracy as administered here is to give a clear picture of the need to pay particular attention to hyperboles of the form examined and other ones not analyzed here for limitations of space.

  11. Comparison and development of sustainable office façade renovation solutions in the Netherlands

    Directory of Open Access Journals (Sweden)

    Michiel Ritzen

    2013-12-01

    Full Text Available Environmental, commercial and societal developments in the Netherlands stimulate the environmental improvement of the existing office building stock. In the Netherlands, about 15% of all office area was vacant in 2012, and the majority of offices have a relative poor energy performance. To measure the improvement, different assessment tools are applied. These tools either focus on one aspect, such as operation energy, and result in a specific outcome such as MJ/m2, or these tools combine different aspects, such as energy and materials, through a weighted system and result in a generic outcome, such as ‘excellent’.In this research, the relation between assessment outcome and actual environmental impact is investigated of both types of tools, by reflecting the outcome of the tool to the carrying capacity of a system. The relation is investigated through a comparison of the energy and material aspect of three office façade renovation solutions using four different assessment tools. Using a tool in which energy and material impact is related to the carrying capacity, current energy focused optimization might lead to a sub optimization of actual environmental impact. To illustrate this, a calculated façade solution is presented with minimal environmental impact based on carrying capacity.

  12. Thermal Performance of Ventilated Double Skin Façades with Venetian Blinds

    Directory of Open Access Journals (Sweden)

    Jordi Parra

    2015-05-01

    Full Text Available Venetian blinds (VB are shading devices of widespread use in residential and corporate buildings. They can reflect or transmit light into buildings and at the same time allow daylighting and exterior views. They can also efficiently block radiative heat from entering the building, and if combined with a heat dissipation system such as forced ventilation, they can improve the thermal performance of double skin façades (DSF. Computational Fluid Dynamics (CFD has proven to be a useful tool for modeling flow and heat transfer in DSF, including conduction, convection and radiation heat transfer phenomena. The aim of this work is to evaluate, by means of CFD, the influence of several optical, construction and operation parameters of a DSF (such as optical properties of the materials, geometrical relations of the VB or flow stream conditions in terms of energy savings, measured as a reduction of the solar load entering the building. Results obtained show that parameters such as the proximity of the VB to the exterior skin of the façade or a differentiated surface treatment for the exterior and interior faces of the VB louvers can notably affect the thermal performance of the DSF and hence the heat gains experienced by the building.

  13. Climate Based Façade Design for Business Buildings with Examples from Central London

    Directory of Open Access Journals (Sweden)

    John Napier

    2015-01-01

    Full Text Available There is a disconnection between commercial architecture and environmental thinking, where green features can be included as part of a strategy for gaining approvals and marketing projects, but those features are not reviewed after completion and occupation of the building and knowledge is not shared. High levels of air conditioning are still considered unavoidable. Elaborate double skin façades and complex motorized shading systems are adopted; often masking an underlying lack of basic environmental thinking. This article returns (in principle to the physics of comfort in buildings and the passive strategies which can help achieve this with a low energy and carbon footprint. Passive and active façade design strategies are outlined as the basis of a critical tool and a design methodology for new projects. A new architectural sensibility can arise based on modeling the inputs of sunlight, daylight and air temperature in time and space at the early stages of design. Early but sound strategies can be tested and refined using advanced environmental modeling techniques. Architecture and environmental thinking can proceed hand in hand through the design process.

  14. Penalaan Parameter Superconducting Magnetic Energy Storage (SMES menggunakan Firefly Algorithm (FA pada Sistem Tenaga Listrik Multimesin

    Directory of Open Access Journals (Sweden)

    Herlambang Setiadi

    2014-03-01

    Full Text Available Energi listrik yang disuplai ke konsumen harus mempunyai stabilitas dan keandalan yang tinggi. Jika terjadi sebuah gangguan pada sistem tenaga listrik dapat mengakibatkan ketidakstabilan. Gangguan tersebut dapat berupa putus jaringan (transien maupun perubahan beban (dinamik. Perubahan beban yang terjadi secara tiba-tiba dan periodik tidak dapat direspon dengan baik oleh generator sehingga dapat mempengaruhi kestabilan dinamik sistem. Hal ini menyebabkan timbul osilasi frekuensi pada generator. Respon yang kurang baik dapat menimbulkan osilasi frekuensi dalam periode yang lama. Hal itu akan mengakibatkan pengurangan kekuatan transfer daya yang ada. Pada sistem tenaga listrik multimachine, semua mesin bekerja secara sinkron se­hingga generator harus beroperasi pada frekuensi yang sama. Untuk meredam osilasi frekuensi yang terjadi dibutuhkan kontroler tambahan yaitu Superconducting Magnetic Energy Storage (SMES. Agar mendapatkan koordinasi controler yang baik maka parameter pada SMES dioptimisasi dengan Firefly Algorithm (FA. Tugas Akhir ini mengajukan konsep penalaan parameter SMES menggunakan FA pada sistem tenaga listrik multimesin. Dengan diajukan metode diatas diharapkan permasalahan osilasi frekuensi akibat terdapat perubahan beban dapat diredam.

  15. A new fast data logger and viewer at Diamond: the FA archiver

    International Nuclear Information System (INIS)

    Abbott, M.G.; Rehm, G.; Uzun, I.S.

    2012-01-01

    At Diamond Light Source, position data from 174 Electron Beam Position Monitors (BPMs) and a number of X-Ray BPMs is distributed over the Fast Acquisition communications network at an update rate of 10 kHz; the total aggregate data rate is around 15 MB/s. The data logger described here (the FA Archiver) captures this entire data stream to disk in real time, re-broadcasts selected subsets of the live stream on demand to interested clients, and allows rapid access to any part of the saved data. The archive is saved into a rolling buffer allowing retrieval of detailed beam position data from any time in the last four days. A simple socket-based interface to the FA Archiver allows easy access to both stored and live data from a variety of clients. Clients include a graphical viewer for visualizing the motion or spectrum of a single BPM in real time, a command line tool for retrieving any part of the stored data by time of day, and Matlab scripts for exploring the dataset, helped by the storage of decimated minimum, maximum, mean, and standard deviation data. (authors)

  16. Cytotoxicity of the dicarboximide fungicides, vinclozolin and iprodione, in rat hepatoma-derived Fa32 cells.

    Science.gov (United States)

    Dierickx, Paul J

    2004-10-01

    Dicarboximide fungicides are widely used to control various fungal species. Their primary action is not known, due to a lack of knowledge concerning the mechanism of action of the dicarboximide group. The cytotoxicities of vinclozolin and iprodione in rat hepatoma-derived Fa32 cells were investigated. Cytotoxicity was measured by neutral red uptake inhibition after treatment for 24 hours. Iprodione was more toxic than vinclozolin. Vinclozolin was less toxic in glutathione-depleted cells than in control cells. This was also true for iprodione at lower concentrations, but iprodione became more toxic at higher concentrations. Both the fungicides increased the endogenous glutathione content by 20% after 1 hour. After 24 hours, the glutathione content was doubled by vinclozolin, but was not affected by iprodione. No effect on glutathione S-transferase activity or reactive oxygen species formation could be observed. Cytochrome P450-dependent ethoxyresorufin-O-deethylase and pentoxyresorufin-O-depentylase activities were moderately activated by iprodione and strongly activated by vinclozolin. A glutathione-related cytochrome P450-dependent metabolic attack of vinclozolin and iprodione could be responsible for their cytotoxicity in Fa32 cells. Further research is needed to fully elucidate these (or other) mechanisms.

  17. Color Image Evaluation for Small Space Based on FA and GEP

    Directory of Open Access Journals (Sweden)

    Li Deng

    2014-01-01

    Full Text Available Aiming at the problem that color image is difficult to quantify, this paper proposes an evaluation method of color image for small space based on factor analysis (FA and gene expression programming (GEP and constructs a correlation model between color image factors and comprehensive color image. The basic color samples of small space and color images are evaluated by semantic differential method (SD method, color image factors are selected via dimension reduction in FA, factor score function is established, and by combining the entropy weight method to determine each factor weights then the comprehensive color image score is calculated finally. The best fitting function between color image factors and comprehensive color image is obtained by GEP algorithm, which can predict the users’ color image values. A color image evaluation system for small space is developed based on this model. The color evaluation of a control room on AC frequency conversion rig is taken as an example, verifying the effectiveness of the proposed method. It also can assist the designers in other color designs and provide a fast evaluation tool for testing users’ color image.

  18. Leaching of biocides used in façade coatings under laboratory test conditions.

    Science.gov (United States)

    Schoknecht, Ute; Gruycheva, Jana; Mathies, Helena; Bergmann, Hannelore; Burkhardt, Michael

    2009-12-15

    The European Biocidal Products Directive 98/8/EC requires a risk assessment concerning possible effects of active ingredients on the environment. Biocides can be leached from treated materials exposed to outdoor use. These emissions have to be estimated and evaluated during the authorization procedure. Different immersion and irrigation tests were performed to investigate leaching of biocides from façade coatings. Several marketed formulations of textured coatings and paints spiked with a mixture of commonly used active ingredients (OIT, DCOIT, IPBC, carbendazim, isoproturon, diuron, terbutryn, and Irgarol 1051) were investigated. The emission process can be described by time-dependent functions that depend on the test conditions. The results of all test procedures confirm that leachability is related to water solubility and n-octanol-water partition coefficient of the active ingredients and that leaching of biocides from façade coatings is mainly a diffusion controlled process. Other factors like the composition of the product, availability and transport of water, concentration of active ingredients in the coatings, as well as UV-exposure of the coatings influence biocide emissions.

  19. Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway

    DEFF Research Database (Denmark)

    Chen, Li; Qanie, Diyako; Jafari, Abbas

    2011-01-01

    Delta-like 1 (Dlk1, also known as fetal antigen-1, FA1) is a member of Notch/Delta family that inhibits adipocyte and osteoblast differentiation; however, its role in chondrogenesis is still not clear. Thus, we overexpressed Dlk1/FA1 in mouse embryonic ATDC5 cells and tested its effects...... on chondrogenic differentiation. Dlk1/FA1 inhibited insulin-induced chondrogenic differentiation as evidenced by reduction of cartilage nodule formation and gene expression of aggrecan, collagen Type II and X. Similar effects were obtained either by using Dlk1/FA1-conditioned medium or by addition of a purified......, secreted, form of Dlk1 (FA1) directly to the induction medium. The inhibitory effects of Dlk1/FA1 were dose-dependent and occurred irrespective of the chondrogenic differentiation stage: proliferation, differentiation, maturation, or hypertrophic conversion. Overexpression or addition of the Dlk1/FA1...

  20. O transplante de medula óssea na leucemia mielóide aguda: análise de 80 pacientes transplantados no complexo do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo The allogeneic and autologous bone marrow transplantation in acute myeloid leukemia: analysis of 80 patients - Bone Marrow Transplantation Service - Hospital das Clínicas of the Medical School, University of São Paulo

    Directory of Open Access Journals (Sweden)

    Nadjanara D. Bueno

    2004-01-01

    Full Text Available Oitenta pacientes consecutivos portadores de Leucemia Mielóide Aguda (LMA submetidos a transplante de medula óssea alogênico (TMO alo e autogênico (TMO auto, foram selecionados entre 1989 e 2001. Quarenta por cento dos mesmos estavam vivos ao final do estudo; no TMO alo 37,9% e no TMO auto 45,4%. Fatores como sexo, classificação Franco-Americano-Britânica de LMA, tratamento de indução, número de células infundidas e regime de condicionamentos não tiveram significância estatística na sobrevida. Pacientes portadores de LMA M1 a M4 e que foram submetidos à consolidação com altas doses de arabinosídeo tiveram melhor sobrevida (p= 0,0148. Pacientes em 1º remissão completa se beneficiaram com TMO alo e auto, com uma sobrevida de 52,6% e 69,2% respectivamente. A presença de doença enxerto contra o hospedeiro (DECH aguda teve impacto na sobrevida dos pacientes quando se comparou ausência de DECH aguda, grau I/II com III/IV (p= 0,0285. Infecção foi a causa de óbito mais freqüente no TMO alo. No TMO auto, a recidiva foi a principal causa de óbito. Morte por toxicidade relacionada ao procedimento ocorreu em 38,9% dos pacientes que morreram no TMO alo e em 16,7% no TMO auto. Na análise univariada de Cox para fatores prognósticos, tiveram significância a fase da doença e a DECH aguda, que perderam significância na análise multivariada (p=0,069.The patients records of eighty consecutive patients with acute myeloid leukemia (AML submitted to allogeneic (allo BMT and autologous (auto BMT bone marrow transplantation (BMT between 1989 and 2001 were assessed. Forty percent were alive in the end of the study; 37.9% of allogeneic patients and 45.4% of autologous. Factors such as gender, the French-American-British AML classification, induction treatment, number of infused cells and the conditioning regiment did not have any impact in survival. Patients with AML from M1 to M4, and who were consolidated with high doses of arabinoside

  1. Intoxicaciones agudas por cocaína: Caracterización, factores de riesgo, conocimientos y precauciones de los consumidores

    OpenAIRE

    Santos Sanz, Sara

    2012-01-01

    La cocaína es la tercera droga ilegal más consumida después del cannabis y las anfetaminas. España es uno de los países donde su consumo está más extendido, sobretodo en el grupo de adultos jóvenes de 15-34 años. Los problemas de salud asociados al consumo de cocaína son frecuentes (13%-30%) entre los consumidores, aunque la intoxicación aguda por cocaína así como sus factores de riesgo no se han estudiado tanto como en el caso de la sobredosis por heroina. Existen vacios en la literatura sob...

  2. Tratamiento con trióxido de arsénico en pacientes con leucemia promielocítica aguda

    Directory of Open Access Journals (Sweden)

    Lidia Clara Suárez Beyríes

    2014-01-01

    Full Text Available Se realizó un estudio observacional, descriptivo y transversal de 17 adultos con leucemia promielocítica aguda, atendidos en el Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba durante un quinquenio, con vistas a evaluar la eficacia del tratamiento de inducción con trióxido de arsénico. En la casuística, la remisión hematológica completa se obtuvo en 82,4 % de sus integrantes a los 42,2 días como promedio. Predominaron la hepatotoxicidad y los dolores óseos como reacciones adversas más comunes, así como también las hemorragias severas como causa principal de muerte. Con este tratamiento se logró la incorporación laboral de quienes mejoraron totalmente y la sobrevida global hasta la fecha es de 76,4 %

  3. Toxicidad aguda oral y subcrónica en ratas de un extracto acuoso liofilizado de Ocimum tenuiflorum L

    OpenAIRE

    A Lagarto; J Tillán; V Bueno; I Chávez; I Guerra; Y Vega; O Valdés; T Gabilondo

    2005-01-01

    El potencial tóxico de un extracto acuoso liofilizado fue evaluado mediante el ensayo de toxicidad aguda oral y subcrónica a 90 días en ratas Wistar de ambos sexos. Los métodos empleados fueron los descritos por las normas OECD. En el ensayo agudo se administró por vía oral la dosis de 2000 mg/kg y en el ensayo subcrónico 250, 500 y 1000 mg/kg/día durante 13 semanas. Se evaluaron los signos tóxicos y peso corporal en ambos ensayos. En el estudio subcrónico además se evalu...

  4. Efecto del ejercicio físico basado en el juego en la leucemia linfocítica aguda

    OpenAIRE

    González García, Laura Ximena; Escobar Zabala, Paola Andrea

    2012-01-01

    Objetivo: Establecer el efecto de un programa de ejercicio físico (EF) basado en el juego sobre el Síndrome de Desacondicionamiento Físico (SDF) de niños con Leucemia Linfocítica Aguda (LLA) entre 5-12 años. Materiales y Métodos: Se realizó un estudio cuasi-experimental con la participación de siete niños tratados por LLA en el Instituto Nacional de Cancerología (INC). Se hizo una evaluación inicial de los determinantes de la condición física (capacidad aeróbica, fuerza muscular, flexibil...

  5. Insuficiência aórtica aguda por avulsão de comissura valvar aórtica

    OpenAIRE

    Cunha,Claudio Ribeiro da; Santos,Paulo César; Atik,Fernando Antibas; Conti,Daniel Oliveira de

    2012-01-01

    Paciente do sexo masculino, de 66 anos, previamente hipertenso, com história de ortopneia, palpitações e dor precordial de início súbito, que teve o diagnóstico de avulsão espontânea de uma comissura valvar aórtica e consequente insuficiência aórtica aguda, evoluindo com insuficiência cardíaca esquerda refratária ao tratamento clínico. O paciente foi submetido precocemente à substituição cirúrgica da valva aórtica por uma bioprótese, e apresentou evolução pós-operatória satisfatória. Atualmen...

  6. Uncária tomentosa e a lesão renal aguda isquêmica em ratos

    Directory of Open Access Journals (Sweden)

    Maria de Fátima Fernandes Vattimo

    2011-03-01

    Full Text Available O objetivo deste estudo foi avaliar o efeito renoprotetor do fitoterápico Uncaria tomentosa sobre a lesão renal aguda isquêmica induzida pelo clampeamento dos pedículos renais de ratos. A hipóxia e a hipoperfusão geradas com a isquemia intensificam a produção de espécies reativas já presentes no processo inflamatório. Os resultados mostraram que a função renal avaliada pelo clearance de creatinina, a excreção de peróxidos urinários (FOX e a excreção urinária de malondealdeído (TBARS desses animais apresentou renoproteção induzida pela UT, provavelmente relacionada às suas atividades antioxidantes.

  7. Relação entre polimorfismos de IL-8 e a gravidade da bronquiolite viral aguda

    OpenAIRE

    Leitão, Lidiane Alves de Azeredo

    2013-01-01

    Introdução : Até os 2 anos de idade, praticamente, todos os lactentes apresentam infecção por vírus sincicial respiratório (VSR). Entretanto, a gravidade da bronquiolite viral aguda (BVA) pode variar significativamente. Essa grande variação pode ser causada por fatores genéticos e imunológicos. Estudos prévios indicam que vias aéreas infectadas por VSR contêm níveis elevados de interleucina-8 (IL-8). O conhecimento de polimorfismos genéticos associados à BVA grave pode ter grande relevância c...

  8. Forma atípica de tireoidite supurativa aguda em paciente pediátrico: relato de caso

    OpenAIRE

    Torres, Maria Rosineide dos S.; Medeiros, Carla C. M.; Nóbrega Neto, Sebastião Horácio; Souza, Lincoln S.; Rodrigues, Mônica L. C.; Silva, Maria Nelice M.; Maior, Lyzandra de H. C. S.; Avelino, Márcia C.; Mourão, Germana T. F.

    2008-01-01

    A tireoidite aguda é uma doença rara. Na infância associa-se principalmente a anormalidades congênitas com acometimento do lobo esquerdo. Na ausência de tireoidopatia preexistente, a função tireoidiana geralmente está normal. Relatamos um caso de uma menina, 6 anos de idade, com tumoração associada a sinais flogísticos na região cervical anterior há 15 dias acompanhada de leucocitose com desvio à esquerda, VSH e TSH elevados. Não havia história prévia de tireoidopatia. A ultra-sonografia da r...

  9. Efecto de la infección aguda con Trypanosoma cruzi sobre el sistema nervioso central de rata gestante

    OpenAIRE

    Lugo de Yarbuh, Ana; Rondón, Johan; Alarcón, Maritza; Moreno, Elio; Araujo, Sonia

    2009-01-01

    Este estudio analizó el efecto de la infección aguda con Trypanosoma cruzi sobre la histología del sistema nervioso central de ratas durante la gestación. Las ratas Wistar fueron infectadas por inoculación intraperitoneal de 5x10(4) tripanosomas sanguícolas de la cepa M/HOM/Bra/53/Y. Para obtener la preñez durante el ascenso de la parasitemia, las ratas en estrus del ciclo menstrual fueron apareadas con los machos a los 12 días posinfección (pi). Ratas vírgenes/infectadas, vírgenes/sanas y sa...

  10. Uso de terapias não convencionais no manejo da crise aguda de asma refratária

    OpenAIRE

    OLIVEIRA RAQUEL HERMES ROSA; RIBEIRO ALEXANDRE DE OLIVEIRA; AMARANTE GUSTAVO ADOLPHO JUNQUEIRA; TEDDE MIGUEL LIA

    2002-01-01

    Uma paciente em crise aguda de asma, refratária ao uso de beta2-agonista inalatório e intravenoso, aminofilina intravenosa e corticóide, em ventilação mecânica, foi tratada com métodos terapêuticos não convencionais: broncoscopia, lavado broncoalveolar com N-acetilcisteína e ventilação com halotano. Houve melhora dos parâmetros ventilatórios após o lavado e a resolução do broncoespasmo ocorreu após a anestesia, propiciando a extubação e alta da UTI. É feita uma revisão da literatura sobre o u...

  11. INFLUENCIA DE LAS FASES LUNARES SOBRE EL RENDIMIENTO DEL MAÍZ (Zea mays variedad NB6

    Directory of Open Access Journals (Sweden)

    Larry Flores Martínez

    2012-10-01

    Full Text Available La observación de las fases lunares para realizar actividades agrícolas, es una costumbre de muchas culturas alrededor del mundo. Sin embargo, existen pocos estudios científicos relacionados con este tema. El objeto  de esta investigación fue determinar la influencia de las fases lunares sobre el rendimiento del maíz. Para ello se consultó a 45 productores de 19 comunidades de la Región Autónoma Atlántico Sur (RAAS, sobre el uso de las fases lunares para la siembra. Además, se estableció un experimento utilizando un diseño de bloques completamente al azar con cuatro repeticiones por cada fase lunar (16 parcelas en total. Se midió el porcentaje de germinación, el crecimiento y rendimiento del cultivo.  Los datos fueron analizados utilizando el programa InfoStat versión 2010. Los resultados reflejan que la germinación de las semillas presentó diferencias estadísticas significativas, siendo mayores en parcelas sembradas en las fases de cuarto creciente y luna nueva. La variable altura, largo y peso de mazorca, no presentaron diferencias significativas según fase lunar. En la variable diámetro del tallo se encontró diferencia significativa; las plantas sembradas en luna nueva presentaron el mayor diámetro. El daño causado por enfermedades y herbívoros presentó un resultado variable para las cuatro fases lunares. El peso promedio del maíz sembrado en la fase de luna nueva fue mayor que en las otras fases, contrario a la creencia popular de los productores de la región.SUMMARYObservation of the moon phases for agricultural activities is a custom in many cultures around the world. However, there are few scientific studies related to this topic. The purpose of this research was to determine the influence of moon phases on corn yields. In order to achieve this goal, 45 producers were consulted from 19 communities in the South Atlantic Autonomous Region (RAAS, regarding the use of the moon phases for sowing. Besides, an

  12. Toxicidad aguda oral de la o-vainillina Acute oral toxicity of o-vanillin

    Directory of Open Access Journals (Sweden)

    Yamisleydi Alonso Moreno

    2008-04-01

    Full Text Available El 2-hidroxi-3-metoxibenzaldehído (o-vainillina posee una probada actividad anti sickling y una baja actividad hemolítica sobre hematíes SS y normales, por lo que puede ser eficaz en el tratamiento de la anemia drepanocítica, enfermedad genética de alta prevalencia a nivel global. En este sentido se desarrolló un estudio de toxicidad aguda oral, con el objetivo de determinar sus efectos adversos. Se administró una dosis de 2 000 mg/kg de peso corporal a un grupo de ratas (3 hembras y 3 machos y el vehículo a otro grupo utilizado como control. Los animales se mantuvieron en observación durante 14 días, se determinaron las variaciones de peso, la presencia o no de síntomas y signos clínicos, y la necropsia al finalizar el estudio. Como resultado no se observó disminución del peso corporal en ninguno de los grupos experimentales, presentaron síntomas como: piloerección, respiración acelerada, actividad disminuida, acicalamiento, aislamiento a la esquina de la caja y la muerte de un animal. El análisis macroscópico de los órganos no detectó variación alguna. La DL50 de la o-vainillina se encuentra por encima de 2 000 mg/kg de peso corporal, según el sistema global armonizado2-hydroxy-3-methoxybenzaldehyde (o-vanillin has a proven anitsickling activity and a low haemolytic activity on SS and normal red corpuscles, so it may be efficient in the treatment of drepanocytic anemia, a genetic disease of high prevalence at the world level. In this sense, an acute oral toxicity study was conducted aimed at determining its adverse effects. A dose of 2 000 mg/kg of body weight was administered to a group of rats (3 females and 3 males, where the vehicle was given to the control group. The animals were observed for 14 days. The variations of weight, the presence or not of symptoms and clinical signs, and the necropsy at the end of the study were determined. Body weight reduction was not observed in any of the experimental groups. They

  13. BRONQUIOLITE AGUDA – O QUE MUDOU NOS ÚLTIMOS 5 ANOS?

    Directory of Open Access Journals (Sweden)

    Ana Lachado

    2016-07-01

    Full Text Available Introdução: A bronquiolite aguda (BA é uma infeção do tra- to respiratório inferior, cujo diagnóstico é clínico, cujo tratamento é essencialmente de suporte. Na maioria dos casos, deve-se a infeção pelo vírus sincicial respiratório (VSR. Em Dezembro de 2012 a Direção Geral da Saúde (DGS emitiu normas de orienta- ção clínica (NOCs com o objetivo de reduzir a utilização desne- cessária de métodos de diagnóstico e terapêutica. Objetivos: Caracterizar os doentes internados com BA no serviço de pediatria de um hospital central e analisar a evolução da abordagem diagnóstica e terapêutica, antes e após a NOC. Métodos: Análise retrospetiva dos processos clínico dos doentes internados com BA, com menos de 24 meses, entre ju- lho de 2010 e junho de 2015. Foram analisados os fatores de risco e de gravidade, incluindo transferência para Cuidados In- tensivos (CI, os meios complementares de diagnóstico (ECD e terapêuticas utilizadas. Resultados: Incluídos 530 doentes, 55% do sexo masculi- no, com mediana de idades de 3.7 meses. Internamento com mediana de 5 dias. Presença de um ou mais fatores de risco associados em 92%. Foi efetuada a pesquisa de vírus no lava- do nasofaríngeo em 81.3% dos casos: VSR (n=272, adenoví- rus (n=52, rinovírus (n=49 e metapneumovírus (n=31. Hou- ve necessidade de transferência para CI em 9.2% dos casos. No 1º, 2º, 3º, 4º e 5º ano foram solicitados ECD em 93.4%; 92.3%; 80.8%; 72.8% e 68.3% dos doentes, respetivamente. O tratamento broncodilatador foi utilizado em 67.1%, 63.5%, 47.5%, 46.2% e 44,2% dos doentes do 1º ao 5º ano, respetiva- mente. A corticoterapia foi utilizada em 32.3%, 21.2%, 23.2%, 33,7% e 16,7% do 1º ao 5º ano, respetivamente. A antibioterapia foi utilizada em 25.1%, 17.3%, 14.1%, 18.5% e 9.2% dos doen- tes de 1º ao 5º ano, respetivamente. A cinesiterapia foi utilizada em 32.5%, 36.5%, 6.1%, 7.6% e 4.2%. dos doentes de 1º ao 5º ano, respetivamente. A

  14. Lesiones periapicales agudas en pacientes adultos Acute periapical lesions in adult patients

    Directory of Open Access Journals (Sweden)

    María Elena Fernández Collazo

    2012-06-01

    Full Text Available Se realizó un estudio analítico de corte transversal en el área de salud del Policlínico "27 de Noviembre" del municipio Marianao, La Habana, en el periodo correspondiente de enero a diciembre de 2009. Se incluyeron todos los pacientes que acudieron al servicio de urgencia y que presentaron lesiones periapicales agudas. Se recogió información de las variables edad, sexo, grupo dentario, causa de la enfermedad, características clínicas e higiene bucal. Esta última se clasificó en las categorías eficiente y deficiente según el índice simplificado de higiene bucal. Se utilizó el X² para estimar la relación entre las variables, y la comparación de proporciones para contrastar la hipótesis de que existieran diferencias entre las lesiones periapicales para las categorías de las variables grupo dentario, causa de la enfermedad y características clínicas. Se encontró un predominio del absceso periapical agudo en un 84,7 % del grupo de edad de 35 a 59 años y del sexo masculino, aunque no se encontraron diferencias significativas para estas variables, ni en los grupos dentarios con respecto a la enfermedad. La higiene bucal resultó estar relacionada con las lesiones periapicales. Se encontraron diferencias significativas en las lesiones periapicales respecto a todas las causas estudiadas, con excepción de las enfermedades periodontales. Respecto a las características clínicas hubo significación en cuanto al aumento de volumen del fondo del surco vestibular y la movilidad dentaria.A cross-sectional and analytical study was conducted in the health area of the "27 de Noviembre" of Marianao municipality, La Habana, from January to December, 2009 including all patients came to emergency service presenting with acute periapical lesions. Information on following variables was available: age, sex, dental group, cause of disease, clinical features and oral hygiene. This latter was classified in the efficient and deficient categories

  15. Proteína C reactiva e gravidade da bronquiolite aguda

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    S. Costa

    2009-01-01

    Full Text Available Resumo: O diagnóstico de bronquiolite aguda é essencialmente clínico. A utilidade de exames laboratoriais, em particular do doseamento da proteína C reactiva (PCR, não está bem estabelecida.O objectivo deste trabalho foi avaliar a relação entre o valor da PCR e os marcadores indirectos de gravidade em doentes com diagnóstico de bronquiolite.Foram incluídos no estudo todos os doentes admitidos no Serviço de Pediatria do HSJ durante o ano de 2006 e que tiveram como diagnóstico principal bronquiolite, tendo sido feita uma revisão retrospectiva do processo clínico desses doentes.Foram incluídos 176 doentes com idades compreendidas entre zero e 36 meses (mediana de 4 meses; 63,1% eram do sexo masculino. O doseamento da PCR tinha sido efectuado em 94,3% dos doentes, com valores compreendidos entre zero e 256 mg/L e com mediana de 11 mg/L.O valor da PCR, na população estudada, apresentou uma relação estatisticamente significativa com a admissão em unidade de cuidados intensivos (UCI (p=0,008, a duração do internamento hospitalar (p=0,025 e a necessidade de oxigenoterapia (p=0,022.Desta forma, este trabalho coloca a hipótese de o valor de PCR poder ser um marcador de gravidade e ter significado prognóstico em doentes com bronquiolite. Mais estudos são necessários para validar estes resultados e esclarecer se existe uma relação real entre as variáveis estudadas ou se esta é produzida pelo efeito confundidor de outras infecções.Rev Port Pneumol 2009; XV (1: 55-65 Abstract: A diagnosis of bronchiolitis is made clinically and the use of supportive laboratory examinations, including the quantification of C reactive protein (CRP, is not well established.The aim of this study was to evaluate the correlation between CRP value and indirect markers of disease severity in patients with bronchiolitis.This study included the patients diagnosed with bronchiolitis admitted to the Pediatrics Department of S. João Hospital in 2006. A

  16. Apendicitis aguda en el anciano: Aspectos clínicos y de laboratorio

    Directory of Open Access Journals (Sweden)

    Víctor E Chian Chang

    1996-01-01

    Full Text Available Objetivo: Describir las manifestaciones clínicas, la correlación clinico-patológica y la importancia de los análisis de laboratorio en la definición del cuadro de apendicitis aguda (AA en el anciano. Material y Métodos: estudio retrospectivo en 100 pacientes de más de 60 años, que fueron hospitalizados en el servicio de emergencia del Hospital Nacional Arzobispo Loayza, durante el periodo 1984-1994. Resultados: En el lapso observado se atendieron un total de 4447 casos de AA en todos los grupo9s erarios, siendo el 3.89% constituido por pacientes ancianos. El tiempo de enfermedad promedio fue de 3.5 días, encontrándose que a mayor duración de esta, se incrementaba la probabilidad de perforación apendicular (X²=19.28 p<0.05. Todos los pacientes presentaron dolor abdominal, pero sólo el 43% tuvo la progresión clásica de este síntoma, se demostró de otro lado, que ha mayor edad, la frecuencia de dolor atípico se incrementaba, (X²=4, p<0.05. Otros síntomas asociados fueron náuseas (73%, vómitos (63% e hiporexia (52%. El signo más frecuente fue el Mc Burney (96.5%, otro signo importante por la frecuencia de presentación fue el signo del Psoas positivo (73.7%; alza térmica solo se detectó en el 43.8%. El hemograma fue normal en 28% y el sedimento de orina fue patológico en 67.2%. El 56% tuvo perforación apendicular como diagnóstico intraoperatorio. El tiempo de hospitalización promedio fue de 13 días y la tasa de mortalidad fue de 6%. Conclusiones: En la población anciana bajo estudio, el tiempo de enfermedad fue significativamente mayor al de la población general, incrementando la probabilidad de perforación apendicular marcadamente; la presencia de síntomas atípicos con respecto al descrito para otros grupos erarios, molestias urinarias frecuentes, menor prevalencia de fiebre, así como análisis de laboratorio básicos de poca ayuda para definir el cuadro podrían explicar esta observación. No se llega a

  17. Lisina digestível para leitoas em fase de crescimento Digestible lysine for growing gilts

    Directory of Open Access Journals (Sweden)

    Gabriel Cipriano Rocha

    2013-05-01

    Full Text Available Oitenta leitoas (24,2±1,52kg com alto potencial genético para deposição de carne na carcaça foram distribuídas em experimento de blocos ao acaso para avaliar cinco níveis de lisina digestível (Ld (9, 10, 11, 12 e 13g kg-1 durante a fase de crescimento (63 a 103 dias de idade. Os animais foram alojados em pares e alimentados à vontade. No início e ao final do período experimental, as leitoas foram pesadas e submetidas à análise de ultrassom para avaliação da área de olho de lombo (AOL e espessura de toucinho (ET. Os níveis de Ld proporcionaram aumento linear (P0,05 dos níveis de Ld sobre o consumo de ração diário (CRD e ET. Os níveis de 12,0 e 12,5g kg-1 de Ld na dieta, correspondentes, respectivamente, ao consumo de lisina digestível diário (CLdD, de 23,6 e 24,6g, proporcionam os melhores resultados de desempenho e área de olho de lombo de leitoas em fase de crescimento (63 aos 103 dias de idade.Eighty gilts (24.2±1.52kg with high genetic potential for lean gain were used in a randomized complete block design to evaluate five digestible lysine levels (9, 10, 11, 12 and 13g kg-1 during the growing phase (63 to 103 days of age. Gilts were housed in pair and fed their respective diets ad libitum. At the begging and the ending of the experimental period, gilts were weighed and scanned by ultrasound to measure loin area, as well as fat depth. The digestible lysine levels linearly increase (P0.05 of the treatments on the fat depth and feed intake. The digestible lysine levels of 12 and 12.5g kg-1, corresponding to the intake of 23.6 e 24.6g dia-1, provide the best results of performance and loin area of growing gilts (63 to 103 days old.

  18. Computer-simulation study on fire behaviour in the ventilated cavity of ventilated façade systems

    Directory of Open Access Journals (Sweden)

    Giraldo María P.

    2013-11-01

    Full Text Available Fire spread through the façades is widely recognized as one of the fastest pathways of fire spreading in the buildings. Fire may spread through the façade in different ways depending on the type of façade system and on the elements and materials from which it is constructed. Ventilated façades are multilayer systems whose main feature is the creation of an air chamber of circulating air between the original building wall and the external cladding. The “chimney effect” in the air cavity is a mechanism that improves the façade's thermal behaviour and avoids the appearance of moisture from rain or condensation. However, in a event of fire, it may contribute to the quickest spreading of fire, representing a significant risk to the upper floors of a building. This study deals with some aspects of fire propagation through the ventilated cavity in ventilated façade systems. Also we review the provisions stipulated by the Spanish building code (Código Técnico de la Edificación, CTE [1] to avoid fire spread outside the building. The results highlight the importance of the use of proper fire barriers to ensure the compartmentalization of the ventilated cavity, as well as the use of non-combustible thermal insulation materials, among others. In addition, based on the results, it might be considered that the measures stipulated by the CTE are insufficient to limit the risks associated with this kind of façades systems. The study has been performed using field models of computational fluid-dynamics. In particular, the Fire Dynamics Simulator (FDS software has been used to numerically solve the mathematical integration models.

  19. Prismatic TIR (total internal reflection) low-concentration PV (photovoltaics)-integrated façade for low latitudes

    International Nuclear Information System (INIS)

    Sabry, Mohamed

    2016-01-01

    Low-concentration Façade-integrated Photovoltaic system in the form of TIR (total internal reflection) prismatic segmented façade could play an effective role in reducing the direct component of solar radiation transmitting through buildings, hence reducing both cooling and artificial lighting load on such buildings. A prismatic segmented façade is capable of allowing diffused skylight to transmit through it to the building interior, while preventing most of the direct solar radiation and converting it into clean energy by means of the integrated PV (​photovoltaics) cells. A range of prismatic TIR segmented façades with different head angles has been designed based on the geographical latitude of the chosen location. Each façade configuration is simulated by ray-tracing technique and its performance is investigated against realistic direct solar radiation data in two clear sky days representing summer and winter of the targeted location. Ray tracing simulations revealed that all of the selected configurations could collect most of the direct solar radiation in summer. In contrary, larger head angle of the segmented façade could collect wider intervals around the noon time till reaching a head angle of 23° at which most of the incident direct solar radiation could be collected. - Highlights: • 5 different head angles of prismatic segmented PV-integrated Façade are ray-traced. • Transmitted and PV-collected solar radiation percentages are determined. • DNI daily profiles with associated solar altitudes and azimuth data are simulated. • Expected transmitted and PV collected solar radiation are calculated for the proposed segments.

  20. Cirurgia conservadora da endocardite bacteriana aguda da valva tricúspide Conservative operation for bacterial endocardites of the tricuspide valve

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    Iseu Affonso da Costa

    1988-08-01

    Full Text Available É relatado o caso de 1 paciente que apresentou endocardite aguda da valva tricúspide pós-aborto, cujo agente causal era o S. aureus. Como não houvesse resposta favorável ao tratamento antibiótico (gentamicina, vancomicina e oxacilina, optou-se pela intervenção, vinte dias após a internação. Foi praticada excisão de uma vegetação única e do tecido valvar adjacente, na comissura ântero-posterior e plicatura anular. O resultado foi favorável, com cura clínica. O exame ecocardiográfico confirmou a presença da vegetação no pré-operatório e o funcionamento conservado da valva, após a plastia. O tratamento cirúrgico, com retirada do tecido infectado e preservação da valva constitui uma alternativa aplicável a certos casos de endocardite aguda das valvas atrioventriculares.One case of acute bacterial endocarditis of the tricuspid valve caused by S. aureus and following a septic abortion is presented. Surgical treatment was indicated after failure of antibiotics. Operation consisted of excision of a large vegetation adherent to the anterior and posterior cusps at the commisure and of the affected valvar tissue. Annular plicature at the segment corresponding to the posterior cuspid was employed to maintain competence. Clinical result was very satisfactory with resolution of sepsis. Dopplerecocardiography revealed the presence of the vegetation before the operation and showed a small regurgitation after valvoplasty. Conservative operation upon the atrioventricular valves must be kept in mind as an alternative in the treatment of acute bacterial endocarditis.

  1. Colecistitis aguda calculosa y síndrome de disfunción múltiple de órganos

    Directory of Open Access Journals (Sweden)

    Jorge Reyes Cardero

    1997-04-01

    Full Text Available Se hizo un estudio de 12 fallecidos, cuya causa principal de muerte fue la peritonitits aguda, que evolucionó hacia el síndrome de disfunción múltiple de órganos. Entre ellos predominó el sexo femenino, la edad avanzada y la presencia de alguna enfermedad asociada o de base. Afectados por una colecistopatía litiásica de más de 1 año de evolución, se demoraron en asistir al Cuerpo de Guardia del Hospital Provincial Clinicoquirúrgico Docente "Saturnino Lora", de Santiago de Cuba, cuando sufrieron los síntomas de colecistitis aguda, de modo que fueron operados en las primeras 24 horas del diagnóstico o después de ese tiempo, pero ya las complicaciones habían condicionado una evolución desfavorable. En algunos casos se hizo necesario reintervenir en más de una ocasiónA study was carried out in 40 deceased patients who died because of an acute peritonitis resulting in a syndrome of multiple organ failure. Most patients were female aged subjects who presented with an associated or baseline disease. Patients were affected by a cholelithiasis with more than I year of evolution and came late to the Emergency Department of "Saturnino Lora" Provincial Teaching hospital when they began to suffer the symptoms of acute cholecystitis, so they were operated on within the first 24 hours of the diagnosis or afterwards, but at that moment complications had led to a nonfavourable evolution. In certain cases it was necessary to reoperate more than once

  2. Hidratación oral continua o a dosis fraccionadas en niños deshidratados por diarrea aguda

    Directory of Open Access Journals (Sweden)

    Mota-Hernández Felipe

    2002-01-01

    Full Text Available Objetivo. Evaluar la seguridad y efectividad de dos técnicas de hidratación oral. Material y métodos. Ensayo clínico aleatorio, hecho en el Servicio de Hidratación Oral del Hospital Infantil de México, Federico Gómez, entre septiembre de 1998 y junio de 1999. Cuarenta pacientes deshidratados por diarrea aguda, menores de cinco años, recibieron suero oral ad libitum (grupo AL y otros cuarenta lo recibieron en dosis fraccionada (grupo DF. Las características clínicas fueron similares en ambos grupos. Los resultados se presentan como promedio y desviación estándar o mediana, según la distribución de frecuencias simples y relativas. Resultados. El promedio de gasto fecal en el grupo AL fue 11.0±7.5 g/kg/h y en el grupo DF 7.1±7.4 (p=0.03. La ingesta de suero, el tiempo de hidratación y la diuresis promedio, fueron similares entre ambos grupos (p>0.05. Seis pacientes del grupo AL y cinco del DF tuvieron gasto fecal alto (>10 g/kg/hora, mejorando con la administración de atole de arroz. Un paciente del grupo AL y dos pacientes del DF tuvieron vómitos persistentes, mejorando con gastroclisis. Ningún paciente requirió rehidratación intravenosa. Conclusiones. Estos resultados sugieren que la administración de suero oral ad libitum, bajo supervisión, es tan segura y efectiva como la técnica de dosis fraccionada para el tratamiento de niños deshidratados por diarrea aguda.

  3. Daño pulmonar agudo relacionado con la transfusión (Trali y Bartonelosis aguda

    Directory of Open Access Journals (Sweden)

    Douglas López de Guimaraes

    2006-07-01

    Full Text Available Se presenta el caso de un varón de 22 años procedente de la periferia de la ciudad de Huaraz, Perú, que acude al Hospital "Victor Ramos Guardia" de Huaraz con un tiempo de enfermedad de 14 días, febril, pálido e ictérico, en el frotis de sangre periférica se encuentran formas bacilares de Bartonella bacilliformis en 99% de la lámina; se inicia tratamiento antibiótico con ceftriaxona y ciprofloxacino. Al día siguiente se le indica transfusión de dos paquetes globulares (puesto que tenía 6,2 g/dL de Hb, dos horas después presenta dolor toráxico, tos seca exigente, vómitos, dificultad respiratoria y cianosis, en la auscultación se encuentran roncantes y crepitantes, la radiografía de tórax muestra infiltrado alveolar difuso a predominio derecho. Es trasladado a la UCI donde recibe oxígeno con máscara de reservorio, dopamina, corticoides y se inicia el monitoreo hemodinámico; responde en forma satisfactoria, sale de alta con frotis negativo a Bartonella bacilliformis. Es el primer caso de daño pulmonar agudo relacionado con la transfusión (TRALI asociado con Bartonelosis aguda con cuadro clínico - radiológico y evolución compatible, es importante distinguir entre la complicación pulmonar debido a la sepsis grave por Bartonelosis aguda, que puede producir un cuadro clínico similar y el TRALI.

  4. Apendicite aguda: achados na tomografia computadorizada - ensaio iconográfico Acute appendicitis: computed tomography findings - an iconographic essay

    Directory of Open Access Journals (Sweden)

    Marcelo Eustáquio Montandon Júnior

    2007-06-01

    Full Text Available A apendicite aguda é a causa mais comum de dor abdominal aguda que requer intervenção cirúrgica no mundo ocidental. O diagnóstico precoce é essencial para minimizar a morbidade da doença. O uso dos métodos de imagem significou grande avanço no diagnóstico desta entidade, até então avaliada apenas com base na história clínica, exame físico e dados laboratoriais, haja vista que 20% a 33% dos pacientes apresentam sintomas atípicos. O diagnóstico é mais difícil nas crianças, nos idosos e nas mulheres em idade fértil. Os principais métodos de imagem para sua avaliação são a ultra-sonografia e a tomografia computadorizada. Os objetivos deste trabalho são: descrever a fisiopatologia da doença, comentar os principais aspectos técnicos da tomografia computadorizada, demonstrar e ilustrar os achados tomográficos e citar os principais diagnósticos diferenciais.Acute appendicitis is the most important cause of abdominal pain requiring surgical intervention in the Western world. The early diagnosis of this disease is of paramount relevance for minimizing its morbidity. Imaging methods have represented a huge progress in the diagnosis of this entity, which used to be based essentially on clinical history, physical examination and laboratory tests results, considering that 20% to 33% of patients present with atypical symptoms. Diagnostic difficulty is higher in children, the elderly, and women in childbearing age. The main imaging methods for evaluation of acute appendicitis are ultrasound and computed tomography. The present study is aimed at describing the disease physiopathology, commenting main computed tomography technical aspects, demonstrating and illustrating tomographic findings, and describing main differential diagnoses.

  5. Valor Diagnóstico do Aumento dos Eosinóftlos e Linfocitos no Lavado Bronco-Alveolar em Doentes com Insuficiência Respiratória Aguda e Infiltrados Pulmonares Difusos

    OpenAIRE

    Kazui Soma; Nobukazu Takada; Masaru Kubota; Masato Katagiri; Nobuo Yanase; Tomoyuki Tomita; Takashj Ohwada

    2000-01-01

    RESUMO: Os autores analisaram de 1983 a 199 1, a utilidade da contagem diferencial de células no Lavado Bronco-Alveolar (LBA) em doentes com Insuficiência Respiratória Aguda (IRA) e Infiltrados Pulmonares Difusos (IPD), com particular interesse nos que apresentavam níveis elevados de eosinóflos ou de linfocitos no LBA. Foram estudados 118 doentes com insuficiência respiratória para aguda e com PaO2

  6. Adaptive Augmenting Control Flight Characterization Experiment on an F/A-18

    Science.gov (United States)

    VanZwieten, Tannen S.; Orr, Jeb S.; Wall, John H.; Gilligan, Eric T.

    2014-01-01

    This paper summarizes the Adaptive Augmenting Control (AAC) flight characterization experiments performed using an F/A-18 (TN 853). AAC was designed and developed specifically for launch vehicles, and is currently part of the baseline autopilot design for NASA's Space Launch System (SLS). The scope covered here includes a brief overview of the algorithm (covered in more detail elsewhere), motivation and benefits of flight testing, top-level SLS flight test objectives, applicability of the F/A-18 as a platform for testing a launch vehicle control design, test cases designed to fully vet the AAC algorithm, flight test results, and conclusions regarding the functionality of AAC. The AAC algorithm developed at Marshall Space Flight Center is a forward loop gain multiplicative adaptive algorithm that modifies the total attitude control system gain in response to sensed model errors or undesirable parasitic mode resonances. The AAC algorithm provides the capability to improve or decrease performance by balancing attitude tracking with the mitigation of parasitic dynamics, such as control-structure interaction or servo-actuator limit cycles. In the case of the latter, if unmodeled or mismodeled parasitic dynamics are present that would otherwise result in a closed-loop instability or near instability, the adaptive controller decreases the total loop gain to reduce the interaction between these dynamics and the controller. This is in contrast to traditional adaptive control logic, which focuses on improving performance by increasing gain. The computationally simple AAC attitude control algorithm has stability properties that are reconcilable in the context of classical frequency-domain criteria (i.e., gain and phase margin). The algorithm assumes that the baseline attitude control design is well-tuned for a nominal trajectory and is designed to adapt only when necessary. Furthermore, the adaptation is attracted to the nominal design and adapts only on an as-needed basis

  7. MR cisternography with three-dimensional fast advanced spin-echo (FASE)

    International Nuclear Information System (INIS)

    Ohgi, Kazuyuki; Yamamoto, Hidefumi; Yokote, Hiroyuki

    2000-01-01

    To evaluate the usefulness of MR cisternography (MRC) combined with various postprocessing techniques and three-dimensional (3D) time-of-flight (TOF) MR angiography, MR cisternograms in 212 patients with various cranial nerve symptoms were retrospectively evaluated. MR examinations were performed with a 1.5 T MR imager using a 3D fast advanced spin-echo (FASE) sequence. Maximum intensity projection (MIP) had the advantage of demonstrating fluid-filled structures such as cerebrospinal fluid (CSF)-internal auditory canal (IAC) and Meckel's cave. Minimum intensity projection (Min IP) was especially useful in delineating neurovascular structures (NVS) in wide CSF space. Addition provided the most well-balanced images of NVS, and was superior to Min IP in the depiction of NVS in narrow CSF space. Virtual endoscopy and volume rendering had the potential to provide additional information in the evaluation of the three-dimensional relationships of NVS. Combination of 3D TOF MRA with MRC was helpful in differentiating arteries, veins, and nerves. With the judicious use of various postprocessing techniques and combined MRA, the value of MRC in the evaluation of patients with various cranial nerve symptoms can be further strengthened. (author)

  8. MR cisternography with three-dimensional fast advanced spin-echo (FASE)

    Energy Technology Data Exchange (ETDEWEB)

    Ohgi, Kazuyuki; Yamamoto, Hidefumi; Yokote, Hiroyuki [Japanese Red-Cross Medical Center, Tokyo (Japan)] [and others

    2000-06-01

    To evaluate the usefulness of MR cisternography (MRC) combined with various postprocessing techniques and three-dimensional (3D) time-of-flight (TOF) MR angiography, MR cisternograms in 212 patients with various cranial nerve symptoms were retrospectively evaluated. MR examinations were performed with a 1.5 T MR imager using a 3D fast advanced spin-echo (FASE) sequence. Maximum intensity projection (MIP) had the advantage of demonstrating fluid-filled structures such as cerebrospinal fluid (CSF)-internal auditory canal (IAC) and Meckel's cave. Minimum intensity projection (Min IP) was especially useful in delineating neurovascular structures (NVS) in wide CSF space. Addition provided the most well-balanced images of NVS, and was superior to Min IP in the depiction of NVS in narrow CSF space. Virtual endoscopy and volume rendering had the potential to provide additional information in the evaluation of the three-dimensional relationships of NVS. Combination of 3D TOF MRA with MRC was helpful in differentiating arteries, veins, and nerves. With the judicious use of various postprocessing techniques and combined MRA, the value of MRC in the evaluation of patients with various cranial nerve symptoms can be further strengthened. (author)

  9. Cuidar de pacientes em fase terminal: a experiência de alunos de medicina

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Araújo Sadala

    2008-03-01

    Full Text Available O objetivo deste estudo foi compreender os significados que alunos de medicina atribuem à experiência de cuidar de pacientes em fase terminal. Os dados foram coletados mediante entrevistas individuais com vinte e quatro estudantes de medicina de uma universidade paulista. As convergências dos depoimentos dos participantes foram agrupadas em três categorias: a deparando-se com o mundo da doença terminal/morte; b relação com o paciente e sua família; c reflexão sobre o cuidar do paciente terminal. Nos depoimentos, os estudantes expressam ansiedade ao cuidar deste tipo de paciente, assim como as dificuldades em lidar com os próprios sentimentos. Consideram-se pouco preparados para relacionar-se com esses pacientes, mas aprenderam com a experiência vivida. Os resultados do estudo apontam para a necessidade de se introduzirem, na formação médica, conteúdos visando desenvolver competências interpessoais e capacidade de reflexão sobre questões de ética e deontologia médica, envolvendo a terminalidade da vida.

  10. El uso de placebo en ensayos clínicos de fase III en Brasil

    Directory of Open Access Journals (Sweden)

    Gustavo Butzge Rubenich

    2015-01-01

    Full Text Available El Consejo Federal de Medicina de Brasil (CFM –órgano normativo y fiscalizador del ejercicio ético de la medicina– prohibió, en 2008, la participación de médicos brasileños en investigaciones que utilizaran placebo para enfermedades con tratamiento eficaz y efectivo, en contraposición a la Declaración de Helsinki, que permite su uso en condiciones metodológicamente justificadas. Con el objetivo de verificar si la normativa ética del CFM modificó el uso de placebo en ensayos clínicos de fase III en Brasil, se analizaron varias características de sus registros en el ClinicalTrials.gov, en los períodos de 2003 a 2007 y de 2009 a 2013. Se concluye que: a la normativa promulgada por el CFM en 2008 fue ineficaz y prevaleció la posición adoptada por la Declaración de Helsinki; b el patrocinio de ensayos con placebo por parte de la industria farmacéutica multinacional fue significativo; c predominaron las investigaciones de fármacos para enfermedades crónicas, y fueron poco significativas para las enfermedades postergadas, de importancia para Brasil.

  11. Aproximación al control de la fase de vuelo de un dirigible

    Directory of Open Access Journals (Sweden)

    Leonardo Solaque Guzmán

    2008-01-01

    Full Text Available El presente trabajo tiene por objetivo el modelo dinámico de un dirigible (como Karma y UrAn, y la elaboración de un conjunto de leyes de control de velocidad, altitud y dirección cuando el dirigible se desplaza en la fase de vuelo crucero. La primera parte del documento presenta un modelo matemático representativo de las principales dinámicas del dirigible. Luego se muestra una descripción de las principales relaciones de las variables, a partir de un modelado e identificación previos, usados para el planteamiento de modelos reducidos, llamados modelos de control. Una segunda parte está dedicada a la formulación de las estrategias de control, basadas en técnicas PID, GPC y una no Lineal. Estas leyes son planteadas sobre la base del desacople de dinámicas para el vuelo lateral y el vuelo longitudinal. Finalmente se incluyen pruebas de simulación y sobre las estructuras reales.

  12. FASES DA TEORIA HUMANÍSTICA: ANÁLISE DA APLICABILIDADE EM PESQUISA

    Directory of Open Access Journals (Sweden)

    Ana Luiza Paula de Aguiar Lélis

    2014-01-01

    Full Text Available El objetivo fue analizar la aplicabilidad de las fases de la Teoría Humanística en investigaciones, según un Modelo de Análisis de Teoría. Estudio de análisis crítica de teoría de enfermería con énfasis en la aplicabilidad. Fue efectuada una búsq ueda, en abril y mayo de 2013, en las bases de datos SCOPUS, Cumulative Index of Nursing and Allied Health Literature y en las disponibles en la Biblioteca Virtual de Salud. Fueron utilizados los descriptores: “Teoria de Enfermagem” y “Pesquisa em Enfermagem” y Nursing Theory y Nursing Research , en publicaciones del 2002 hasta mayo de 2013. Siete artículos fueron seleccionados, de los cuales cinco revelaron todas las etapas en su desarrollo, evidenciando la aplicabilidad de la Teoría Humanística como soporte metodológico e n las investigaciones de enfermería.

  13. A Decision Support Concept for a construction design project – selecting the type of glass façade

    Directory of Open Access Journals (Sweden)

    Franjo Šimić

    2017-01-01

    Full Text Available The paper describes research into the possibility of developing a concept for supporting decisions in planning construction projects (one of the most important stages of construction project management. The focus is on supporting decisions in selecting the type of and solution for the glass façade in the main design. Materials and types of soluteons for a glass façade were analyzed and alternative solutions were obtained. The concept was developed in that it included relevant stakeholders in the decision-making process during the construction design. These stakeholders were the investor, architect, and construction contractor. The analysis was carried out and a hierarchical structure of objectives was formed as a goal tree. The criteria at the last hierarchical level were used to evaluate alternative solutions for the glass façade, and their weights were determined by all stakeholders using the AHP method (Analytic Hierarchy Process. Using PROMETHEE (Preference Ranking Method for Enrichment Evaluation, a comparison of alternative solutions for the glass façade was conducted and the alternatives were ranked according to the priorities for inclusion into the main design. The concept was tested by selecting a type of glass façade on a residential-commercial building in the city of Rijeka, Croatia.

  14. An enhanced functional ability questionnaire (faVIQ to measure the impact of rehabilitation services on the visually impaired

    Directory of Open Access Journals (Sweden)

    James Stuart Wolffsohn

    2014-02-01

    Full Text Available AIM:To develop a short, enhanced functional ability Quality of Vision (faVIQ instrument based on previous questionnaires employing comprehensive modern statistical techniques to ensure the use of an appropriate response scale, items and scoring of the visual related difficulties experienced by patients with visual impairment.METHODS:Items in current quality-of-life questionnaires for the visually impaired were refined by a multi-professional group and visually impaired focus groups. The resulting 76 items were completed by 293 visually impaired patients with stable vision on two occasions separated by a month. The faVIQ scores of 75 patients with no ocular pathology were compared to 75 age and gender matched patients with visual impairment.RESULTS:Rasch analysis reduced the faVIQ items to 27. Correlation to standard visual metrics was moderate (r=0.32-0.46 and to the NEI-VFQ was 0.48. The faVIQ was able to clearly discriminate between age and gender matched populations with no ocular pathology and visual impairment with an index of 0.983 and 95% sensitivity and 95% specificity using a cut off of 29.CONCLUSION:The faVIQ allows sensitive assessment of quality-of-life in the visually impaired and should support studies which evaluate the effectiveness of low vision rehabilitation services.

  15. Formal language of Lanna Shop House’s Façade in Lampang Old city, Thailand

    Science.gov (United States)

    Phetsuriya, Natthakit

    2017-10-01

    This article aims to presents ‘the formal architectural language of Lanna Designs” that is a linguistic paradigm for decrypt the linguistic system which is hidden in the Lanna façade style. Lanna Designs present an identity of vital ordered and crucial articulated formal language which inherently set of mathematical rules for the arrangement of ornaments. The scope of this article is attempted to the morphology of façades of the ten shop houses which located in Lampang Old city and have familiar proportion and style. In this article, the sampling of façade buildings required proportion as three-stall and two-story with familiar style. The morphology is described based on terms of a symbolic encoding system that is represented as graphically building grammar. The system helps to emphasize commonalities in façade languages and propose a prototype of identified Lanna façade design. This methodology might be the option for decrypt or study in every facades style.

  16. Field-Evolved Mode 1 Resistance of the Fall Armyworm to Transgenic Cry1Fa-Expressing Corn Associated with Reduced Cry1Fa Toxin Binding and Midgut Alkaline Phosphatase Expression

    Science.gov (United States)

    Jakka, Siva R. K.; Gong, Liang; Hasler, James; Banerjee, Rahul; Sheets, Joel J.; Narva, Kenneth; Blanco, Carlos A.

    2015-01-01

    Insecticidal protein genes from the bacterium Bacillus thuringiensis (Bt) are expressed by transgenic Bt crops (Bt crops) for effective and environmentally safe pest control. The development of resistance to these insecticidal proteins is considered the most serious threat to the sustainability of Bt crops. Resistance in fall armyworm (Spodoptera frugiperda) populations from Puerto Rico to transgenic corn producing the Cry1Fa insecticidal protein resulted, for the first time in the United States, in practical resistance, and Bt corn was withdrawn from the local market. In this study, we used a field-collected Cry1Fa corn-resistant strain (456) of S. frugiperda to identify the mechanism responsible for field-evolved resistance. Binding assays detected reduced Cry1Fa, Cry1Ab, and Cry1Ac but not Cry1Ca toxin binding to midgut brush border membrane vesicles (BBMV) from the larvae of strain 456 compared to that from the larvae of a susceptible (Ben) strain. This binding phenotype is descriptive of the mode 1 type of resistance to Bt toxins. A comparison of the transcript levels for putative Cry1 toxin receptor genes identified a significant downregulation (>90%) of a membrane-bound alkaline phosphatase (ALP), which translated to reduced ALP protein levels and a 75% reduction in ALP activity in BBMV from 456 compared to that of Ben larvae. We cloned and heterologously expressed this ALP from susceptible S. frugiperda larvae and demonstrated that it specifically binds with Cry1Fa toxin. This study provides a thorough mechanistic description of field-evolved resistance to a transgenic Bt crop and supports an association between resistance and reduced Cry1Fa toxin binding and levels of a putative Cry1Fa toxin receptor, ALP, in the midguts of S. frugiperda larvae. PMID:26637593

  17. First International Workshop on Human Factors in Modeling (HuFaMo 2015)

    DEFF Research Database (Denmark)

    Störrle, Harald; Chaudron, Michel R. V.; Amaral, Vasco

    2015-01-01

    human factors in modeling. Our goal is to improve the state of the science and professionalism in empirical research in the Model Based Engineering community. Typical examples of research questions might consider the usability of a certain approach, such as a method or language, or the emotional states......Modeling is a human-intensive enterprise. As such, many research questions related to modeling can only be answered by empirical studies employing human factors. The International Workshop Series on Human Factors in Modeling (HuFaMo) is dedicated to the discussion of empirical research involving...... or personal judgements of modelers. While concerned with foundations and framework support for modeling, the community has been somehow neglecting the issue of human factors in this context. There is a growing need from the community concerned with quality factors to understand the best practices...

  18. Verrerie de Passavant-la-Rochère/faïencerie de Salins

    OpenAIRE

    Barbe, Noël

    2007-01-01

    Le travail du verre est présent dès le Moyen Age à Passavant-la-Rochère. A Salins, la production céramique date du début du xviiie siècle. Sur chacun de ces sites subsiste une unité de production représentant par ailleurs la dernière activité de ce type dans la région administrative constituée par la Franche-Comté. La verrerie de Passavant-la-Rochère est une entreprise familiale employant 250 ouvriers. La faïencerie de Salins est aujourd'hui intégrée au groupe Sarreguemines-Digoin dont elle c...

  19. Figlina u Fažani i njezina preobrazba u kasnoj antici

    OpenAIRE

    Bulić, Davor; Koncani Uhač, Ida

    2011-01-01

    Figlina u Fažani prvi se put spominje u stručnoj literaturi početkom XX. stoljeća. Proučavanje proizvoda i njihove distribucije na tržište te pitanje vlasništva figline intenzivira se kroz zadnja tri desetljeća prošlog stoljeća. Zaštitna arheološka istraživanja (2007. - 2009.) omogućila su prikupljanje više ili manje cjelovitih podataka o mikrolokaciji radioničkog kompleksa i keramičkih proizvoda. Ovaj prilog predstavlja pokušaj sistematizacije dostupnih podataka i njihov...

  20. Wing Torsional Stiffness Tests of the Active Aeroelastic Wing F/A-18 Airplane

    Science.gov (United States)

    Lokos, William A.; Olney, Candida D.; Crawford, Natalie D.; Stauf, Rick; Reichenbach, Eric Y.

    2002-01-01

    The left wing of the Active Aeroelastic Wing (AAW) F/A-18 airplane has been ground-load-tested to quantify its torsional stiffness. The test has been performed at the NASA Dryden Flight Research Center in November 1996, and again in April 2001 after a wing skin modification was performed. The primary objectives of these tests were to characterize the wing behavior before the first flight, and provide a before-and-after measurement of the torsional stiffness. Two streamwise load couples have been applied. The wing skin modification is shown to have more torsional flexibility than the original configuration has. Additionally, structural hysteresis is shown to be reduced by the skin modification. Data comparisons show good repeatability between the tests.