WorldWideScience

Sample records for faisceaux radioactifs par

  1. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  2. Linear study and bundle adjustment data fusion; Application to vision localization; Recherche lineaire et fusion de donnees par ajustement de faisceaux; Application a la localisation par vision

    Energy Technology Data Exchange (ETDEWEB)

    Michot, J.

    2010-12-09

    integrate this additional information directly into an extended bundle adjustment, by adding a constraint term in the weighted cost function. We evaluate three methods (based on machine learning or regularization) that dynamically select the weight associated to the constraint and show that these methods can be used in a real time multi-sensor SLAM, and validate them with different types of constraint on the orientation or on the scale. Experiments conducted on real video sequences show that this technique of constrained bundle adjustment reduces the drifts observed with the classical vision algorithms and improves the global accuracy of the positioning system. (author) [French] Les travaux presentes dans ce manuscrit concernent le domaine de la localisation et la reconstruction 3D par vision artificielle. Dans ce contexte, la trajectoire d'une camera et la structure 3D de la scene filmee sont initialement estimees par des algorithmes lineaires puis optimisees par un algorithme non-lineaire, l'ajustement de faisceaux. Cette these presente tout d'abord une technique de recherche de l'amplitude de deplacement (recherche lineaire), ou line search pour les algorithmes de minimisation iterative. La technique proposee est non iterative et peut etre rapidement implantee dans un ajustement de faisceaux traditionnel. Cette technique appelee recherche lineaire algebrique globale (G-ALS), ainsi que sa variante a deux dimensions (Two way-ALS), accelerent la convergence de l'algorithme d'ajustement de faisceaux. L'approximation de l'erreur de reprojection par une distance algebrique rend possible le calcul analytique d'une amplitude de deplacement efficace (ou de deux pour la variante Two way-ALS), par la resolution d'un polynome de degre 3 (G-ALS) ou 5 (Two way-ALS). Nos experimentations sur des donnees simulees et reelles montrent que cette amplitude, optimale en distance algebrique, est performante en distance euclidienne, et permet

  3. The conditioning of radioactive waste by bitumen; Conditionnement des dechets radioactifs par le bitume

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J; Scheidhauer, J; Malabre, M [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1961-07-01

    The separation of radioactive sludge and waste by bitumen is studied. Results are given concerning various trials carried out on the lixiviation of the final product by water as a function of the pH, of the time, and of the composition. The conditions for carrying out this process of coating the waste are controlled from a radioactive point of view. (author) [French] L'isolement de boues radioactives et de dechets par le bitume est etudie. Les resultats de divers essais portant sur la lixiviation par l'eau du produit fini en fonction du pH, du temps et de la composition sont exposes. Les conditions de realisation de l'enrobage sont controlees au point de vue du risque radioactif. (auteur)

  4. Experimental study of contamination by inhalation of radioactive iodine aerosols. Biological balance; Etude experimentale de la contamination par inhalation d'aerosols d'iode radioactif bilan biologique

    Energy Technology Data Exchange (ETDEWEB)

    Marble, G [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    Several articles have been published concerning research into contamination produced by inhalation of radioactive iodine aerosols in monkeys. Results dealing with the biological balance of this contamination are presented and discussed in this report. (author) [French] L'etude experimentale de la contamination par inhalation d'aerosols d'iode radioactif effectuee chez le singe a fait l'objet de plusieurs publications. Les resultats concernant le bilan biologique de cette contamination sont presentes et discutes dans ce rapport. (auteur)

  5. Production of chemically reactive radioactive ion beams through on-line separation; Production de faisceaux d'ions radioactifs chimiquement reactifs par separation en ligne

    Energy Technology Data Exchange (ETDEWEB)

    Joinet, A

    2003-10-01

    The ISOL (isotope separation on line) allows the production of secondary radioactive ion beams through spallation or fragmentation or fission reactions that take place in a thick target bombarded by a high intensity primary beam. The challenge is to increase the intensity and purity of the radioactive beam. The optimization of the system target/source requires the right choice of material for the target by taking into account the stability of the material, its reactivity and the ionization method used. The target is an essential part of the system because radioactive elements are generated in it and are released more or less quickly. Tests have been made in order to select the best fitted material for the release of S, Se, Te, Ge and Sn. Materials tested as target filling are: ZrO{sub 2}, Nb, Ti, V,TiO{sub 2}, CeO{sub x}, ThO{sub 2}, C, ZrC{sub 4} and VC). Other molecules such as: COSe, COS, SeS, COTe, GeS, SiS, SnS have been studied to ease the extraction of recoil nuclei (Se, S, Te, Ge and Sn) produced inside the target.

  6. Production of chemically reactive radioactive ion beams through on-line separation; Production de faisceaux d'ions radioactifs chimiquement reactifs par separation en ligne

    Energy Technology Data Exchange (ETDEWEB)

    Joinet, A

    2003-10-01

    The ISOL (isotope separation on line) allows the production of secondary radioactive ion beams through spallation or fragmentation or fission reactions that take place in a thick target bombarded by a high intensity primary beam. The challenge is to increase the intensity and purity of the radioactive beam. The optimization of the system target/source requires the right choice of material for the target by taking into account the stability of the material, its reactivity and the ionization method used. The target is an essential part of the system because radioactive elements are generated in it and are released more or less quickly. Tests have been made in order to select the best fitted material for the release of S, Se, Te, Ge and Sn. Materials tested as target filling are: ZrO{sub 2}, Nb, Ti, V,TiO{sub 2}, CeO{sub x}, ThO{sub 2}, C, ZrC{sub 4} and VC). Other molecules such as: COSe, COS, SeS, COTe, GeS, SiS, SnS have been studied to ease the extraction of recoil nuclei (Se, S, Te, Ge and Sn) produced inside the target.

  7. Elimination of slightly radioactive liquid effluent by dilution. Its consequences (1960); Elimination par dilution d'effluents liquides faiblement radioactifs. Leurs consequences (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Bovard, P; Candillon, C [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    Nuclear centres often have to solve problems raised by the elimination of large volumes of slightly radioactive liquid effluent. As things stand at present, the method usually adopted consists in expelling this effluent into the main water system in order to dilute it to a maximum, and thus to lower its radioactive isotope concentration to below the norms imposed by the Public Health Service. This technique requires systematic checking of the water system and its dependences, and demands a thorough knowledge of adsorption and fixation processes. (author) [French] Les centres nucleaires ont frequemment a resoudre des problemes poses par l'elimination de volumes importants d'effluents liquides faiblement radioactifs. Dans l'etat actuel des choses, la solution la plus utilisee consiste a rejeter ces effluents dans le reseau hydrographique de maniere a les diluer au maximum et abaisser ainsi leurs teneurs en isotopes radioactifs au-dessous des normes imposees par la Sante Publique. Cette technique necessite un controle systematique du reseau et de ses dependances et demande une connaissance approfondie des processus d'adsorption et de fixation. (auteur)

  8. Beach sediments drift study by means of radioactive tracers; L'etude du transport littoral par la methode des traceurs radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Hours, R [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Jaffry, P [Electricite de France (EDF), 78 - Chatou (France). Lab. National d' Hydraulique

    1959-07-01

    The present state of the sediments drift studies by means of radioactive tracers is exposed. Various processes of labelling, immersion and detection, used in France and other countries, are reviewed. A more extended analysis of some aspects of the problem by the same authors can be found in 'La Houille Blanche', number 3, may-june 1959 (Rapport C.E.A. number 1269). (author) [French] L'etude du transport littoral des sediments et galets par la methode des traceurs radioactifs est en plein developpement. Le present rapport precise l'etat actuel de la question. Les techniques de marquage, d'immersion et de detection utilisees en France et a l'etranger sont decrites; une analyse plus detaillee de certains aspects de la question est presentee par les memes auteurs dans 'La Houille Blanche', numero 3, mai-juin 1959 (Rapport C.E.A. numero 1269). (auteur)

  9. Health problems raised by the elimination of radioactive wastes and nuclear accidents; Problemes sanitaires poses par l'elimination des dechets radioactifs et par les accidents nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Jammet, H; Mechali, D; Dousset, M [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-07-01

    residus radioactifs produits par les installations nucleaires. L'evaluation du risque encouru par les populations et la fixation des limites admissibles pour les rejets ne peuvent resulter que d'une connaissance exacte du cheminement des radioelements rejetes, depuis leur source d'emission jusqu'a l'homme. L'incorporation des radioelements dans les chaines alimentaires constitue le premier risque a prendre en consideration. Les facteurs de passage doivent etre envisages, dans toutes les etapes de cette transmission, qu'elles interessent les milieux physiques ou les milieux proprement biologiques, du fait de leur continuite et de leur interdependance. Enfin, les donnees de caractere socio-economique et dietetique doivent etre recueillies pour conduire a une evaluation des risques et des niveaux admissibles reposant non sur des donnees theoriques mais sur des bases concretes et experimentales. Le risque d'accidents nucleaires dans l'industrie atomique, bien que de probabilite tres reduite, doit etre pris en consideration du fait de la gravite de leurs consequences. Les problemes sanitaires se posent d'une part dans le domaine de l'hygiene professionnelle, d'autre part dans celui de l'hygiene publique. Le premier domaine implique un risque double: d'irradiation et de contamination. Le domaine public n'est soumis essentiellement qu'au risque de contamination par les substances radioactives liberees accidentellement dans le milieu. Les etudes sanitaires a mener dans ce domaine comprennent, de ce fait, les recherches sur la therapeutique des irradiations ou des contaminations mais aussi celles relatives au transfert des radioelements depuis l'installation accidentee jusqu'a l'homme, principalement a travers les chaines alimentaires, dans leurs composantes physiques comme dans leurs composantes biologiques. De telles etudes sont a la base des decisions d'ordre sanitaire qu'il conviendrait de prendre dans le cas d'un accident. (auteurs)

  10. Health problems raised by the elimination of radioactive wastes and nuclear accidents; Problemes sanitaires poses par l'elimination des dechets radioactifs et par les accidents nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Jammet, H.; Mechali, D.; Dousset, M. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-07-01

    residus radioactifs produits par les installations nucleaires. L'evaluation du risque encouru par les populations et la fixation des limites admissibles pour les rejets ne peuvent resulter que d'une connaissance exacte du cheminement des radioelements rejetes, depuis leur source d'emission jusqu'a l'homme. L'incorporation des radioelements dans les chaines alimentaires constitue le premier risque a prendre en consideration. Les facteurs de passage doivent etre envisages, dans toutes les etapes de cette transmission, qu'elles interessent les milieux physiques ou les milieux proprement biologiques, du fait de leur continuite et de leur interdependance. Enfin, les donnees de caractere socio-economique et dietetique doivent etre recueillies pour conduire a une evaluation des risques et des niveaux admissibles reposant non sur des donnees theoriques mais sur des bases concretes et experimentales. Le risque d'accidents nucleaires dans l'industrie atomique, bien que de probabilite tres reduite, doit etre pris en consideration du fait de la gravite de leurs consequences. Les problemes sanitaires se posent d'une part dans le domaine de l'hygiene professionnelle, d'autre part dans celui de l'hygiene publique. Le premier domaine implique un risque double: d'irradiation et de contamination. Le domaine public n'est soumis essentiellement qu'au risque de contamination par les substances radioactives liberees accidentellement dans le milieu. Les etudes sanitaires a mener dans ce domaine comprennent, de ce fait, les recherches sur la therapeutique des irradiations ou des contaminations mais aussi celles relatives au transfert des radioelements depuis l'installation accidentee jusqu'a l'homme, principalement a travers les chaines alimentaires, dans leurs composantes physiques comme dans leurs composantes biologiques. De telles etudes sont a la base des decisions d'ordre sanitaire qu

  11. Exotic nuclei and radioactive beams; Noyaux exotiques et faisceaux radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Chomaz, P.

    1996-12-31

    The Nuclei called exotic are all the nuclei that it is necessary to recreate in laboratory to study them. Their life time is too short -in relation to earth age- for it remains enough on earth. The researchers are going to have at their s disposal at GANIL (Caen) with the S.P.I.R.A.L. project, exotic nuclei beams and will study new kinds of nuclear reactions to better understand the atom nucleus. (N.C.). 2 refs., 9 figs.

  12. Experimental study of contamination by inhalation of radioactive iodine aerosols. Biological balance; Etude experimentale de la contamination par inhalation d'aerosols d'iode radioactif bilan biologique

    Energy Technology Data Exchange (ETDEWEB)

    Marble, G. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    Several articles have been published concerning research into contamination produced by inhalation of radioactive iodine aerosols in monkeys. Results dealing with the biological balance of this contamination are presented and discussed in this report. (author) [French] L'etude experimentale de la contamination par inhalation d'aerosols d'iode radioactif effectuee chez le singe a fait l'objet de plusieurs publications. Les resultats concernant le bilan biologique de cette contamination sont presentes et discutes dans ce rapport. (auteur)

  13. Kinetic ion exchange studies in ultramarines by the radioactive tracer method; Etudes cinetiques d'echanges d'ions dans les outremers par la technique des traceurs radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    May, S; Goenvec, H; Pinte, G [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    The possibility of ion exchanges in various ultramarines has been studied in the aqueous phase. The kinetics of the exchange reactions is followed by studying the behaviour of a radioactive ion, either in the solution of the exchanging salt or in the ultramarine itself. The sodium in the make-up of the ultramarine, is found to exchange with various ions in solution. The reaction speeds appear to be governed by a diffusion process inside the grains of ultramarine. The diffusion coefficients and the activation energies are determined for the exchanges studied. Several exchange studies were carried out in an organic medium. The kinetics of ion exchange is also investigated in ultramarines from which most of the constituent sulphur has been eliminated. The results obtained in these ultramarines are compared with the exchange kinetics of the same ions in ordinary ultramarine. (author) [French] Nous avons etudie la possibilite d'echanges ioniques dans differents outremers, en phase aqueuse. L'etude cinetique des reactions d'echanges est suivie en etudiant le comportement d'ion radioactif, soit dans la solution du sel echangeant, soit dans l'outremer lui-meme. C'est le sodium de constitution de l'outremer qui s'echange avec differents ions en solution. Les vitesses de reactions semblent etre controlees par un processus de diffusion a l'interieur des grains d'outremer. Les coefficients de diffusion et les energies d'activation sont determines pour les echanges etudies. Quelques etudes sont realisees en milieu organique ou quelques echanges ont ete etudies. La cinetique d'echange d'ions est egalement etudie dans des outremers dans lesquels la majorite du soufre de constitution a ete eliminee. On compare les resultats obtenus dans ces outremers avec les cinetiques d'echanges des memes ions dans l'outremer ordinaire. (auteur)

  14. Use of electron beams for the production of radioactive nuclei through photo-fission; Utilisation de faisceaux d'electrons pour la production des noyaux radioactifs par photo-fission

    Energy Technology Data Exchange (ETDEWEB)

    M' garrech, Slah

    2004-09-01

    The IPN (institute of nuclear physics) of Orsay decided to build a linear accelerator in order to produce an electron beam of 50 MeV energy and of 10 {mu}A average intensity. It is the ALTO project (Linear Accelerator near the Tandem of Orsay). This project will be dedicated to the production of the radioactive ions using the photo-fission process. The central topic of this thesis is the study of the beam dynamics of the ALTO facility. The first part presents studies concerning the injector. The simulations made with the simulation code PARMELA allowed the optimization of the characteristics of pre-buncher (dephasing HF, accelerating field peak...) to obtain a good bunching factor at the entrance of the buncher and at the entrance of the accelerating section according to the distance separating the two systems. The second part of this thesis is related to measurements of transverse emittance of the beam at the buncher exit. The three gradients method has been selected and the optical system used is a solenoid. The results obtained are in good agreement with former measurements. Finally a calculation of the beam line was carried out to optimize the transport of the beam to the PARRNe target without degrading its characteristics. The calculation codes that have been used are BETA and TRACE-WIN. (author)

  15. Shape coexistence in krypton and selenium light isotopes studied through Coulomb excitation of radioactive ions beams; Etude de la coexistence de formes dans les isotopes legers du krypton et du selenium par excitation Coulombienne de faisceaux radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Clement, E

    2006-06-15

    The light krypton isotopes show two minima in their potential energy corresponding to elongated (prolate) and compressed (oblate) quadrupole deformation. Both configuration are almost equally bound and occur within an energy range of less than 1 MeV. Such phenomenon is called shape coexistence. An inversion of the ground state deformation from prolate in Kr{sup 78} to oblate in Kr{sup 72} with strong mixing of the configurations in Kr{sup 74} and Kr{sup 76} was proposed based on the systematic of isotopic chain. Coulomb excitation experiments are sensitive to the quadrupole moment. Coulomb excitation experiments of radioactive Kr{sup 74} and Kr{sup 76} beam were performed at GANIL using the SPIRAL facility and the EXOGAM spectrometer. The analysis of these experiments resulted in a complete description of the transition strength and quadrupole moments of the low-lying states. They establish the prolate character of the ground state and an oblate excited state. A complementary lifetime measurement using a 'plunger' device was also performed. Transition strength in neighboring nuclei were measured using the technique of intermediate energy Coulomb excitation at GANIL. The results on the Se{sup 68} nucleus show a sharp change in structure with respects to heavier neighboring nuclei. (author)

  16. MUST, a set of strip detectors for studying radioactive beams induced reactions; MUST, un ensemble de detecteurs a pistes pour l`etude des reactions induites par faisceaux radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Blumenfeld, Y.; Barbier, A.; Beaumel, D.; Charlet, D.; Clavelin, J.F.; Douet, R.; Engrand, M.; Lebon, S.; Lelong, P.; Lesage, A.; Leven, V.; Lhenry, I.; Marechal, F.; Petizon, L.; Pouthas, J.; Richard, A.; Rougier, D.; Soulet, C.; Suomijaervi, T.; Volkov, P.; Voltolini, G. [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire; Auger, F.; Ottini, S.; Alamanos, N. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee; Sauvestre, J.E.; Bonnereau, B.; Champion, L.; Delbourgo-Salvador, P.; Ethvignot, T.; Szmigiel, M. [CEA Centre d`Etudes de Bruyeres-le-Chatel, 91 (France)

    1996-12-31

    This report states the specificity of light particles elastic scattering, and the need of detecting recoil protons to improve angular resolution. Then the development of a specific MUST strip detector is detailed: 60 strips detectors with Si O sub 2 dielectric, that yield 500 ps time resolution, and Si (Li) detectors following next. A versatile data acquisition system has been developed too, with CAMAC interface to suit to any experimental plant. (D.L.). 27 refs.

  17. Recovery of sludge from the treatment of liquid radioactive effluents by co-precipitation with calcium carbonate: laboratory study; Recuperation des boues de traitement des effluents radioactifs liquides par coprecipitation avec le carbonate de calcium: etude de laboratoire

    Energy Technology Data Exchange (ETDEWEB)

    Patti, F.; Gailledreau, C.; Cohen, P.

    1961-02-24

    As during the treatment by co-precipitation with calcium carbonate of liquid radioactive residues, a partial decontamination can be obtained by simply agitating an already formed radioactive sludge with the effluent to be processed, the authors study whether it would be possible to first perform a co-precipitation with a lower dose of calcium carbonate and then to complete decontamination by agitating with an adequate quantity of sludge stored during preceding operations. The authors report the study of the influence of reactant quantity on the chemical treatment efficiency, of the evolution of the activity of a radioactive residual solution in contact with a precipitate, of the cleaner element, of a precipitate reuse, of the technological and economic aspects, and of another possibility of reduction of the precipitate volume [French] Dans le traitement par coprecipitation avec le carbonate de calcium des residus radioactifs liquides, une decontamination partielle peut etre obtenue en agitant simplement une boue radioactive deja formee avec l'effluent a traiter. En consequence, il pourrait etre possible d'effectuer d'abord une coprecipitation avec une dose plus faible de carbonate de calcium et de completer ensuite la decontamination en agitant le liquide avec une quantite convenable de boue stockee a partir d'operations precedentes. (auteurs)

  18. Quantitative analysis of strontium 90 in the radioactive wastes by means of thenoyltrifluoroacetone; Dosage du strontium 90 dans les effluents radioactifs par le thenoyltrifluoroacetone

    Energy Technology Data Exchange (ETDEWEB)

    Testemale, G; Leredde, J L [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1970-07-01

    A simple method of analysing the quantity of {sup 90}Sr has been perfected. It consists in a double extraction of it by means of thenoyltrifluoroacetone and tributylphosphate in tetrachloride of carbon followed by eliminating yttrium 90 by means of thenoyltrifluoroacetone in the benzene. Numberings on aliquot parts of wastes make the determination of that element possible. The yield is about 97 per cent. (authors) [French] Une technique simple du dosage du {sup 90}Sr a ete mise au point. Elle consiste en une double extraction par le thenoyltrifluoroacetone et le tributylphosphate dans le tetrachlorure de carbone, suivie de l'elimination de l'yttrium 90 par le thenoyltrifluoroacetone dans le benzene, Des comptages sur des parties aliquotes d'effluents permettent la dermination de cet element. Rendement environ 97 pour cent. (auteurs)

  19. Dosage of cesium 137 in radioactive wastes by the application of sodium tetraphenylborate; Dosage du cesium 137 dans les effluents radioactifs par le tetraphenylborate de sodium

    Energy Technology Data Exchange (ETDEWEB)

    Testemale, G; Girault, J [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1967-07-01

    A simple technique of the dosage of {sup 137}Cs has been developed. The technique consists in the formation of cesium tetraphenyl borate, followed by a double extraction with isoamyl acetate, and washing of the organic phase. The counting of known parts of the cesium solution assaying of its purity by {gamma} spectrometry enable the determination of the {sup 137}Cs. The yield is about 98 per cent. (authors) [French] Une technique simple du dosage du {sup 137}Cs a ete mise au point. Elle consiste en une double extraction du tetraphenylborate de cesium forme par l'acetate d'isoamyle suivie d'un lavage de la phase organique. Des comptages sur des parties aliquotes de la solution de cesium et un controle de purete par spectrometrie {gamma} permettent la determination de cet element. Rendement: environ 98 pour cent. (auteurs)

  20. Pharmacological study of radioactive-gold colloid transport by blood and by serous exudate; Contribution a l'etude pharmacologique du transport des colloides d'or radioactif par le sang et les exsudats sereux

    Energy Technology Data Exchange (ETDEWEB)

    Rousselet, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1966-06-01

    substances et particulierement dans le transport de l'or colloidal radioactif. Les fractions sanguines qui peuvent participer au transport de l'or colloidal sont les hematies, les leucocytes et elements histiocytaires, et le plasma. La repartition de la radioactivite dans ces elements est precisee en pratiquant des autoradiographies de coupes de culots de sang centrifuge et congele apres incubation avec de l'or colloidal. Cette etude montre l'importance du plasma dans le transport des particules radioactives. Nous avons alors recherche une fixation eventuelle de l'or colloidal 198 sur les diverses proteines seriques en appliquant certaines methodes de separation a savoir une filtration-exclusion sur colonne de gel de Sephadex G-200 et un fractionnement electrophoretique sur papier et sur acetate de cellulose gelatineux (cellogel). Nous avons etudie la liaison ''in vitro'' et ''in vivo'' des particules colloidales d'or 198 d'abord avec les proteines seriques de sujets sains puis avec les proteines des liquides d'epanchement d'origine pathologique, chez l'homme, ou du a une inflammation experimentale a la carragenine chez le rat. Les particules d'or colloidal 198 de 30 m{mu} (S-2) sont liees dans une certaine mesure aux {alpha}2 globulines sanguines ou ascitiques, celles de 5 m{mu} (S-6) sont liees aux {alpha}1 globulines de meme que les grains contenus dans l'or polydisperse. Cette liaison semble intervenir grace a la couche protectrice de macromolecules constituees par la gelatine. Seules les caracteristiques physicochimiques de grains colloidaux peuvent expliquer leur difference de localisation sur l'electrophoregramme. L'or sous forme ionique, par contre, est combine, aux seules albumines si la quantite de metal presente ne depasse pas une certaine limite. (auteur)

  1. Pharmacological study of radioactive-gold colloid transport by blood and by serous exudate; Contribution a l'etude pharmacologique du transport des colloides d'or radioactif par le sang et les exsudats sereux

    Energy Technology Data Exchange (ETDEWEB)

    Rousselet, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1966-06-01

    transport de l'or colloidal radioactif. Les fractions sanguines qui peuvent participer au transport de l'or colloidal sont les hematies, les leucocytes et elements histiocytaires, et le plasma. La repartition de la radioactivite dans ces elements est precisee en pratiquant des autoradiographies de coupes de culots de sang centrifuge et congele apres incubation avec de l'or colloidal. Cette etude montre l'importance du plasma dans le transport des particules radioactives. Nous avons alors recherche une fixation eventuelle de l'or colloidal 198 sur les diverses proteines seriques en appliquant certaines methodes de separation a savoir une filtration-exclusion sur colonne de gel de Sephadex G-200 et un fractionnement electrophoretique sur papier et sur acetate de cellulose gelatineux (cellogel). Nous avons etudie la liaison ''in vitro'' et ''in vivo'' des particules colloidales d'or 198 d'abord avec les proteines seriques de sujets sains puis avec les proteines des liquides d'epanchement d'origine pathologique, chez l'homme, ou du a une inflammation experimentale a la carragenine chez le rat. Les particules d'or colloidal 198 de 30 m{mu} (S-2) sont liees dans une certaine mesure aux {alpha}2 globulines sanguines ou ascitiques, celles de 5 m{mu} (S-6) sont liees aux {alpha}1 globulines de meme que les grains contenus dans l'or polydisperse. Cette liaison semble intervenir grace a la couche protectrice de macromolecules constituees par la gelatine. Seules les caracteristiques physicochimiques de grains colloidaux peuvent expliquer leur difference de localisation sur l'electrophoregramme. L'or sous forme ionique, par contre, est combine, aux seules albumines si la quantite de metal presente ne depasse pas une certaine limite. (auteur)

  2. Study of radioactive nuclides of very short half-life produced by fast neutrons; Etude de corps radioactifs a vie tres breve produits par neutrons rapides

    Energy Technology Data Exchange (ETDEWEB)

    Monnand, E [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1965-07-01

    Several radionuclides, already known, with half-lives ranging from 5 10{sup -5} to 1 second were observed by pulsed irradiations of C - Mg - Al - Y - In - Tl - Pb - Bi with 14.3 MeV neutrons. These radionuclides are: {sup 12}B (20 {+-} 0.4 ms) - {sup 24m}Na (20 {+-} 0.6 ms) - {sup 88m1}Y (0.332 {+-} 0.012 ms) - {sup 88m2}Y (14.6 {+-} 0.4 ms) - {sup 114m}In (43.5 {+-} 2 ms) - {sup 202m}Tl (0.570 {+-} 0.010 ms) - {sup 204m}Tl (0.063 {+-} 0.002 ms) - {sup 205m}Pb (5.5 {+-}0.3 ms) - {sup 206m}Pb (0.126 {+-} 0.006 ms) - {sup 207m}Pb (830 {+-} 30 ms) - {sup 208m}Bi (2.56 {+-} 0.1 ms). Their half-life, the {beta} and {gamma} rays energies and the production cross sections were measured. (author) [French] Plusieurs radionucleides deja connus, de periode comprise entre 5 10{sup -5} et 1 seconde ont ete observes par irradiation pulsee avec des neutrons de 14,3 MeV, des elements suivants: C - Mg - Al - Y - In - Tl - Pb - Bi. Ces radionucleides sont: {sup 12}B (20 {+-} 0.4 ms) - {sup 24m}Na (20 {+-} 0.6 ms) - {sup 88m1}Y (0.332 {+-} 0.012 ms) - {sup 88m2}Y (14.6 {+-} 0.4 ms) - {sup 114m}In (43.5 {+-} 2 ms) - {sup 202m}Tl (0.570 {+-} 0.010 ms) - {sup 204m}Tl (0.063 {+-} 0.002 ms) - {sup 205m}Pb (5.5 {+-}0.3 ms) - {sup 206m}Pb (0.126 {+-} 0.006 ms) - {sup 207m}Pb (830 {+-} 30 ms) - {sup 208m}Bi (2.56 {+-} 0.1 ms). Leur periode, l'energie des rayonnements {beta} et {gamma} emis, et la section efficace de production ont ete mesurees. (auteur)

  3. Processing radioactive effluents with ion-exchanging resins: study of result extrapolation; Traitement des effluents radioactifs par resines echangeuses d'ions: etude de l'extrapolation des resultats

    Energy Technology Data Exchange (ETDEWEB)

    Wormser, G.

    1960-05-03

    As a previous study showed the ion-exchanging resins could be used in Saclay for the treatment of radioactive effluents, the author reports a study which aimed at investigating to which extent thus obtained results could be extrapolated to the case of higher industrial columns. The author reports experiments which aimed at determining extrapolation modes which could be used for columns of organic resin used for radioactive effluent decontamination. He notably studied whether the Hiester and Vermeulen extrapolation law could be applied. Experiments are performed at constant percolation flow rate, at varying flow rate, and at constant flow rate [French] Plusieurs etudes ont ete faites dans le but d'examiner les possibilites d'emploi des resines echangeuses d'ions pour le traitement des effluents radioactifs. Dans un rapport preliminaire, nous avons montre dans quelles limites un tel procede pouvait etre utilise au Centre d'Etudes Nucleaires de Saclay. Les essais ont ete effectues sur des petites colonnes de resine au laboratoire; il est apparu ensuite necessaire de prevoir dans quelle mesure les resultats ainsi obtenus peuvent etre extrapoles a des colonnes industrielles, de plus grande hauteur. Les experiences dont les resultats sont exposes dans ce rapport, ont pour but de determiner les modes d'extrapolation qui pourraient etre employes pour des colonnes de resine organique utilisees pour la decontamination d'effluents radioactifs. Nous avons en particulier recherche si la loi d'extrapolation de Hiester et Vermeulen qui donne de bons resultats dans le cas de fixation d'ions radioactifs en presence d'un ion macrocomposant sur des terres, pouvait etre appliquee. Les experiences, en nombre limite, ont montre que la loi d'extrapolation de Hiester et Vermeulen pouvait s'appliquer dans le cas de l'effluent considere quand les debits de percolation sont tres faibles; quand ils sont plus forts, les volumes de liquide percoles, a fixation egale, sont proportionnels aux

  4. Disposal of Low-Activity Liquid Effluents by Dilution; Elimination par Dilution d'Effluents Liquides Faiblement Radioactifs; 0423 0414 0410 041b 0414 ; Eliminacion de Efluentes Liquidos de Baja Radiactividad por Dilucion

    Energy Technology Data Exchange (ETDEWEB)

    Bovard, P.; Candillon, C. [Service de Controle des Radiations et de Genie Radioactif, Commissariat a l' Energie Atomique, Saclay (France)

    1960-07-01

    obtenus Nous avons commence en 1957 une etude evolutive de l'incidence des installations nucleaires. Cette etude embrasse la determination des niveaux - de radioactivite naturelle - de contamination artificielle afin d'en degager la part revenant aux Centres Nucleaires. Des exemples sont cites faisant appel a des zones de reference. La plus grande partie de la radioactivite artificielle semble due aux retombees radioactives; ceci n'est pas surprenant si on examine les quantites d'isotopes radioactifs rejetees jusqu'a present en France. Un certain nombre d'essais de laboratoire ont ete effectues. Ils ont contribue a preciser certains mecanismes, ont accru notre connaissance de la pollution des sites et nous ont permis d'ameliorer nos methodes de prelevement. II. Essais de laboratoire Ils ont porte: 1. sur des 'phenomenes d'adsorption analogues a ceux produits dans les rivieres au cours de la dilution des effluents: fixation sur mineraux tres divises: mica, quartz. Des radioisotopes tels que {sup 90}Sr, {sup 137}Cs, {sup 90}Y semblent se comporter fort differemment: dans les conditions moyennes de rejet, le {sup 90}Sr serait le moins adsorbe. : 2. sur la contamination du sol et des vegetaux par l'emploi de colonnes et de cubes de sol en place. Ceci nous a conduit a standardiser nos prelevements, afin de faciliter les analyses ulterieures et de comparer utilement les resultats. III. Choix du site et modalites des rejets De ce faisceau de resultats et d'etudes encore incomplets, nous essayons de degager quelques principes quant au choix des sites. Le site une fois defini, l'experience acquise permet de tirer le meilleur parti des possibilites naturelles. (author) [Spanish] Con los resultados obtenidos en Francia vigilando la radiactividad en las proximidades de las instalaciones nucleares se pueden extraer determinadas conclusiones acerca de la eleccion de los procedimientos de evacuacion. I. Resultados obtenidos Los autores iniciaron en 1957 un estudio evolutivo de las

  5. A contribution to the study of radioactive waste dilution in the Rhone involving tests with a rhodamine B tracer; Contribution a l'etude de la dilution des effluents radioactifs dans le Rhone par le rejet experimental de rhodamine B

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J.; Marichal, M. [Commissariat a l' energie atomique et aux energies alternatives - CEA, Centre de production de plutonium de Marcoule, Service de protection contre les radiations (France)

    1961-07-01

    The process whereby waste from the Marcoule plant mixes with the water in the Rhone was followed in tests with rhodamine as a chemical tracer. Satisfactory dispersion was noted less than 4 km downstream from the waste discharge duct outlet, and the degree of homogeneity was considered to be satisfactory at the bridge of Roquemaure, und perfect at Avignon. This investigation not only revealed a complete absence of any preferential flow paths containing high radioactive waste concentrations, but it also enabled the most representative points to be selected at which to take Rhone water samples during future radioactive waste discharges. Reprint of a paper published in 'La Houille Blanche' N. 5 - Aug 196, p. 636-641 [French] L'emploi de la rhodamine comme traceur chimique a permis de suivre l'evolution du melange des effluents du Centre de Marcoule aux eaux du Rhone. La dispersion est deja satisfaisante a moins de 4 km en aval de la conduite des rejets, et l'homogeneite peut etre consideree comme atteinte au pont de Roquemaure et parfaite a Avignon. Cette etude a montre que les veines preferentielles ou se concentrait l'ecoulement des effluents radioactifs n'existent pas. Elle a permis de preciser en outre les emplacements les plus representatifs des points d'echantillonnage des eaux du Rhone au cours des rejets. Reproduction d'un article publie dans 'La houille blanche' N. 5 - Aug 196, p. 636-641.

  6. Resonant ionization by laser beams: application to ions sources and to study the nuclear structure of radioactive tellurium isotopes; Ionisation resonante par faisceaux laser: application aux sources d'ions et a l'etude de la structure des noyaux radioactifs de tellure

    Energy Technology Data Exchange (ETDEWEB)

    Sifi, R

    2007-07-15

    The radioactive ion beams that are produced through current isotope separators are well separated according to the A mass but not according to the Z parameter. The resonant ionization through laser beams applied to ion sources allows the production of radioactive ion beam in a very selective and efficient way by eliminating the isobaric contamination. The first chapter is dedicated to the resonant ionization by laser beams, we describe the principle, the experimental setting, the lasers used, the ionization schemes and the domain of application. The second chapter deals with the application of resonant ionization to laser ion sources for the production of radioactive ion beams. We present experimental tests performed for getting copper ion beams. Resonant ionization through laser is also used in the spectroscopy experiments performed at the Isolde (isotope separation on-line device) installation in CERN where more than 20 elements are ionized very efficiently. The technique is based on a frequency scanning around the excitation transition of the atoms in order to probe the hyperfine structure. Laser spectroscopy allows the determination of the hyperfine structure as well as the isotopic shift of atoms. In the third chapter the method is applied to the spectroscopy of tellurium atoms. First, we define the 2 parameters on which the extraction is based: charge radius and nuclear moments, then we present several theoretical models that we have used to assess our experimental results. (A.C.)

  7. New Research Required in Support of Radioactive Waste Disposal; Recherches Nouvelles Necessitees par le Probleme de l'Elimination des Dechets Radioactifs; 041d 0415 041e 0411 0425 041e 0414 ; Nuevas Investigaciones Necesarias para la Evacuacion de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Schaefer, Milner B. [Inter-American Tropical Tuna Commission, Scripps Institution of Oceanography, La Jolla, CA (United States)

    1960-07-01

    foraines typiques, sur les processus de diffusion et de sedimentation dans les eaux proches du rivage et sur le passage des elements radioactifs tout le long de la chaine alimentaire dans cette partie de la mer. Il faut entreprendre des recherches pour delimiter les zones de peche presentes et eventuelles et les zones ou la peche ne se fait pas, en procedant a des etudes fondamentales sur la productivite biologique ou en recourant a d'autres moyens. Des etudes sont egalement necessaires pour determiner les taux de transfert de matieres radioactives entre les diverses zones par amenee hori-zontale et par diffusion turbulente, les taux de dilution par diffusion, sedimentation et transport vertical, et les taux d'entrainement et de transfert par les organismes. Une recherche s'impose en ce qui concerne les moyens efficaces de controle des zones d'evacuation des dechets. Certains organismes sont capables de concentrer selectivement des elements determines ;1 cette capacite constitue une base economique eventuelle pour le controle des dechets radioactifs existant dans la mer a des concentrations extremement faibles. Des propositions precises de recherche ont ete recemment mises au point par plusieurs groupes d'oceanographes aux Etats-Unis. Ces propositions ont ete resumees en meme temps que les estimations de. depenses y afferentes. (author) [Spanish] Numerosos son los procesos fisicos, quimicos y biologicos que influyen en la forma en que las sustancias radiactivas se distribuyen y vuelven al hombre. Entre ellos figuran la conveccion vertical y horizontal; la difusion turbulenta; la precipitacion y sedimentacion; la captacion, concentracion y transporte de los materiales radiactivos por organismos, y su paso al hombre por ingestion de alimentos de origen marino. Hay que estudiar urgentemente las caracteristicas del flujo y reflujo de las aguas en puertos tipicos, estuarios y aguas costeras abiertas ; los procesos de difusion y sedimentacion en las aguas costeras, y el paso de

  8. Production of intense metallic ion beams in order of isotopic separations; Production de faisceaux intenses d'ions metalliques en vue de la separation des isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Sarrouy, J L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1955-07-01

    We describe an isotope separator with magnetic sector of 60 deg that permits, with a process of neutralization of the space charge, to use efficiently intense ion beams. The sources of realized ions provide ionic debits of 10 mA. This present work deals who to obtain intense ion beams (10 to 15 mA), different processes of ion currents measurement, as well as the study of the phenomenon of space charge neutralization. The second part of this memory will be on the survey and the adaptation on the source of various type of oven permitting to spray and to ionize metals directly. By order of increasing difficulty of vaporization, we reached the chromium. (M.B.) [French] 0n decrit un separateur d'isotope a secteur magnetique de 60 deg qui permet, grace a un procede de neutralisation de la charge d'espace, d'utiliser efficacement des faisceaux d'ions intenses. Les sources d'ions realisees fournissent des debits ioniques de 10 mA. Ce present travail porte sur l'obtention de faisceaux d'ions faisceaux d'ions intenses (10 a 15 mA), des differents procedes de mesures des courants d'ions, ainsi que l'etude du phenomene de neutralisation de charge d'espace. La deuxieme partie de ce memoire portera sur l'etude et l'adaptation sur la source de divers type de four permettant de vaporiser et d'ioniser directement les metaux. Par ordre de difficulte croissantes de vaporisations, nous avons atteint le chrome. (M.B.)

  9. From the coupling between ion beam analysis techniques and physico-chemical characterization methods to the study of irradiation effects on materials behaviour; Du couplage des techniques d'analyse par faisceaux d'ions et des methodes de caracterisation physico-chimique a l'etude des effets d'irradiation sur le comportement des materiaux

    Energy Technology Data Exchange (ETDEWEB)

    Millard-Pinard, N

    2003-07-01

    The general purpose of my research work is to follow and to interpret the surface evolution of materials, which have received several treatments. During my PhD and my post-doc work, my field of research was tribology. Since I arrived in the 'Aval du Cycle Electronucleaire' group of the Institut de Physique Nucleaire de Lyon, my research activities are in line with the CNRS program 'PACE ' (Programme sur l'Aval du Cycle Electronucleaire) within the ACTINET network. They are coordinated by the PARIS (Physico-chimie des actinides et autres radioelements en solution et aux interfaces) and NOMADE (NOuveaux MAteriaux pour les DEchets) GDR with ANDRA (Agence Nationale pour la gestion des Dechets RAdioactifs), EDF and IRSN (Institut de Radioprotection et de Surete Nucleaire) as partner organisations. My work focused on the study of fission products and actinides migration in barrier materials, which may be capable of assuring the long term safety of deep geological repositories. Until now, it was necessary to use the coupling of ion beam analysis techniques and physico-chemical characterization techniques. During the last few months, I have became interested in understanding radiolytic effects. This new orientation has led us to use ion beams as an irradiating tool. These irradiation experiments are pursued in three major projects. The study of cobalt sulfide inhibition effects of radiolysis gas production during the irradiation of model organic molecules. This is a collaboration with the IRSN, the Institut de Recherche sur la Catalyse and the Ecole Nationale Superieure des Mines de Saint-Etienne. A PhD, co-directed by M. Pijolat from ENSMSE and myself, concerning this study will start in October 2003. Water radiolysis effects on iron corrosion are also studied in the particular case of vitrified nuclear waste containers, which will be stored in deep geological repositories. One ANDRA financed PhD, co-directed by Nathalie Moncoffre and myself, is dedicated to this study

  10. From the coupling between ion beam analysis techniques and physico-chemical characterization methods to the study of irradiation effects on materials behaviour; Du couplage des techniques d'analyse par faisceaux d'ions et des methodes de caracterisation physico-chimique a l'etude des effets d'irradiation sur le comportement des materiaux

    Energy Technology Data Exchange (ETDEWEB)

    Millard-Pinard, N

    2003-07-01

    The general purpose of my research work is to follow and to interpret the surface evolution of materials, which have received several treatments. During my PhD and my post-doc work, my field of research was tribology. Since I arrived in the 'Aval du Cycle Electronucleaire' group of the Institut de Physique Nucleaire de Lyon, my research activities are in line with the CNRS program 'PACE ' (Programme sur l'Aval du Cycle Electronucleaire) within the ACTINET network. They are coordinated by the PARIS (Physico-chimie des actinides et autres radioelements en solution et aux interfaces) and NOMADE (NOuveaux MAteriaux pour les DEchets) GDR with ANDRA (Agence Nationale pour la gestion des Dechets RAdioactifs), EDF and IRSN (Institut de Radioprotection et de Surete Nucleaire) as partner organisations. My work focused on the study of fission products and actinides migration in barrier materials, which may be capable of assuring the long term safety of deep geological repositories. Until now, it was necessary to use the coupling of ion beam analysis techniques and physico-chemical characterization techniques. During the last few months, I have became interested in understanding radiolytic effects. This new orientation has led us to use ion beams as an irradiating tool. These irradiation experiments are pursued in three major projects. The study of cobalt sulfide inhibition effects of radiolysis gas production during the irradiation of model organic molecules. This is a collaboration with the IRSN, the Institut de Recherche sur la Catalyse and the Ecole Nationale Superieure des Mines de Saint-Etienne. A PhD, co-directed by M. Pijolat from ENSMSE and myself, concerning this study will start in October 2003. Water radiolysis effects on iron corrosion are also studied in the particular case of vitrified nuclear waste containers, which will be stored in deep geological repositories. One ANDRA financed PhD, co-directed by Nathalie Moncoffre and myself, is

  11. The Permanent Disposal of Highly Radioactive Wastes by Incorporation into Glass; Elimination Permanente de Dechets Hautement Radioactifs par Incorporation dans le Verre; 041e 041a 041e 041d 0427 0414 ; La Evacuacion Permanente de Desechos de Elevada Radiactividad Incorporandolos en Vidrio

    Energy Technology Data Exchange (ETDEWEB)

    Watson, L. C.; Aikin, A. M.; Bancroft, A. I. [Atomic Energy of Canada Ltd. (Canada)

    1960-07-01

    verre contenant un melange de produits de fission ayant cinq ou six ans d'age et dont l'activite allait jusqu'a 50 curies par kilogramme. L'operation s'est faite en discontinu, par lots de quatre kilogrammes. On a constate que les produits de fission peuvent etre incorpores dans le verre commodement et sans danger. En etudiant les nombreux problemes que posent le stockage et l'elimination permanents du verre hautement radioactif, on est parvenu a la conclusion que ce verre devrait etre, soit enfoui dans le sol, soit entrepose dans des souterrains artificiels. Dans ces conditions, il est toujours possible, en cas de besoin, de' proceder a un nouveau controle de l'elimination. Lorsque l'enfouissement se fait directement dans le sol, les produits de fission peuvent surtout etre liberes dans le milieu ambiant par lixiviation du verre dans l'eau. On estime donc important de connaitre le rythme auquel les produits de fission se dispersent par ce mecanisme. Une documentation abondante sur la lixiviation par l'eau a ete recueillie en laboratoire. On a constate que le rythme de liberation depend de la composition du verre. Pour toutes les compositions mises a l'epreuve, les mesures montrent que le rythme de lixiviation des produits de fission incorpores dans le verre decroit avec le temps. Apres plusieurs mois d'immersion dans l'eau, le rythme auquel les substances radioactives se degageaient du verre de differentes compositions etait de 10{sup -4} pour cent par an environ, pour des hemispheres en verre pesant deux kilogrammes. Les donnees recueillies ont servi a evaluer les quantites de produits de fission qui s'echapperont du verre auquel auront ete incorporees les masses importantes de produits de fission qui s'accumuleront par suite du fonctionnement des reacteurs de puissance. (author) [Spanish] En Chalk River se ha continuado el estudio de un proceso para incorporar en vidrio para su evacuacion permanente los desechos de alto nivel radiactivo resultantes de los procesos de

  12. Use of a thin-film evaporator for bitumen coating of radioactive concentrates; Utilisation d'un evaporateur a couche mince pour l'enrobage par le bitume de concentrats radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Lefillatre, G; Rodier, J; Hullo, R; Cudel, Y; Rodi, L [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1969-07-01

    Following the development in the laboratory of a process for coating evaporation concentrates with bitumen, a technological study of this coating process has been undertaken. The report describes a pilot installation for the bitumen coating of concentrates, which uses a thin-film evaporator LUWA L 150. The first, inactive series of tests was designed to determine the maximum and optimum capacities of the evaporator by varying the amounts of bitumen and of concentrate, the rotor speed and the thermo-fluid temperature. Two rotors were tested, one of conventional type, the other a model especially designed for high viscosity products. The maximum capacity of evaporation of the apparatus is 72 kg/hr for a heating temperature of 221 deg. C. During normal operation, the evaporator can produce 50 kg/hr of coated product containing 55 to 60 per cent of bitumen (Mexphalte 40/50), the water content of the product remaining under 0.5 per cent. A second series of tests will shortly be carried out on this pilot installation using, in particular, bituminous emulsions containing mainly Mexphalte 40/50 and 80/100. (authors) [French] A la suite de la mise au point en laboratoire d'un procede d'enrobage par le bitume de concentrats d'evaporation, une etude technologique de cet enrobage a ete entreprise. Ce rapport decrit une installation pilote d'enrobage par le bitume de concentrats utilisant un evaporateur a couche mince LUWA L 150. La premiere serie d'essais en inactif a eu pour but de definir les capacites maximales et optimales de l'evaporateur en faisant varier les dosages en bitume et en concentrats, la vitesse du rotor et la temperature du thermo-fluide. Deux rotors ont ete testes, l'un de type classique, l'autre d'un modele special concu pour les produits de haute viscosite. La capacite d'evaporation maximale de l'appareil est de 72 kg/h d'eau pour une temperature de chauffage de 221 deg. C. En marche normale l'evaporateur peut debiter 50 kg/h d'enrobe compose de 55 a 60

  13. Electronic sorting of radioactive ores; Triage electronique des minerais radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Sandier, J.

    1958-01-15

    Electronic sorting of radioactive ores consists in passing the rock lumps, after sieving, one by one in front of radioactivity detectors; these detectors command electromechanical systems which class the ores according to their radioactivity level. This note sets on the state of progress of the work going on at the D.R.E.M.: use of scintillometers for γ-ray detection, with circuits carrying magnetic memories to improve their operation; results of laboratory and semi-industrial tests on several deposits; description of the material, data on the first factory project; notes on the financial returns of the process. A description is also given of the electronic sorting material used skip by skip for a first rough classification of the ores according to their content, as they leave the shaft. (author) [French] Le triage electronique des minerais radioactifs consiste a faire passer, apres criblage, les cailloux un par un devant des detecteurs de radioactivite; ces detecteurs commandent des systemes electromecaniques qui classent les minerais selon leur niveau de radioactivite. La note expose l'etat d'avancement des travaux en cours a la D.R.E.M: utilisation des scintillometres pour la detection des rayonnements γ, de circuits comportant des memoires magnetiques pour ameliorer le fonctionnement; resultats d'essais de laboratoire et semi-industriels sur plusieurs gisements; description du materiel, donnees sur le premier projet d'usine; notes sur la rentabilite du procede. Est egalement decrit le materiel de triage electronique skip par skip utilise pour une premiere classification grossiere des minerais selon leurs teneurs, des la sortie des puits. (auteur)

  14. The Practice of Waste Disposal in the United Kingdom Atomic Energy Authority; Methodes Employees par l'Atomic Energy Authority du Royaume-Uni pour Eliminer les Dechets Radioactifs; 041f 041e 0420 042f 0414 041e 041a 0423 0414 ; Sistemas de Evacuacion de Desechos en la United Kingdom Atomic Energy Authority

    Energy Technology Data Exchange (ETDEWEB)

    Dunster, H. J.; Wix, L. F.U. [United Kingdom Atomic Energy Authority, Health and Safety Branch (United Kingdom)

    1960-07-01

    The United Kingdom Atomic Energy Authority operates establishments in locations ranging from the South of England to the North coast of Scotland. The functions of these establishments include the production and processing of nuclear fuels, the production of electricity and isotopes for commercial sale, the development of new types of reactors and the conduct of research in all the associated fields. The Authority therefore has a wide variety of wastes to deal with and they arise in a number of different places. The main high-activity wastes, both liquid and solid, are stored in special tanks and containers, while the low-activity large-volume liquid wastes are released in carefully controlled amounts to the sea or to rivers. Low-and medium- activity solid wastes are buried in selected areas where there will be no interference with water supplies, or sunk on to the sea bed. The paper summarizes the methods in use and gives typical quantities of liquid and solid waste arising annually for disposal by the various methods. (author) [French] Les divers etablissements de VAtomic Energy Authority du Royaume-Uni sont echelonnes entre le sud de l'Angleterre et la cote septentrionale de l'Ecosse. Ces etablissements sont notamment charges de la fabrication et du traitement des combustibles nucleaires, de la production d'electricite et de la production d'isotopes a des fins commerciales, de la mise au point de nouveaux modeles de reacteurs et des recherches effectuees dans tous les domaines connexes. L' Atomic Energy Authority doit donc proceder, en plusieurs points du territoire, a l'elimination de toute une serie de dechets radioactifs d'origines diverses. Les principaux dechets, liquides et solides, a radioactivite elevee sont enfermes dans des reservoirs et recipients speciaux, tandis que les volumineux dechets liquides a faible radioactivite sont evacues, par quantites soigneusement controlees, dans la mer ou les cours d'eau. Les dechets solides, de radioactivite faible

  15. Safety apparatus for serious radioactive accidents (1962); Materiel d'intervention en cas d'accident radioactif grave (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Estournel, R; Rodier, J [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1962-07-01

    In the case of a serious radioactive accident, radioactive dust and gases may be released into the atmosphere. It is therefore necessary to be able to evaluate rapidly the importance of the risk to the surrounding population, and to be able to ensure, even in the event of an evacuation of the Centre, the continuation of the radioactivity analyses and the decontamination of the personnel. For this, the Anti-radiation Protection Service at Marcoule has organised mobile detection teams and designed a mobile laboratory and a mobile shower-unit. After describing the duty of the mobile teams, the report gives a description of the apparatus which would be used at the Marcoule Centre in the case of a serious radioactive accident. The method of using this apparatus is given. (authors) [French] Lors d'un accident radioactif grave, des poussieres et des gaz radioactifs peuvent etre relaches dans l'atmosphere. II est alors indispensable d'evaluer rapidement l'importance du risque couru par les populations environnantes, et de pouvoir assurer, meme dans le cas de l'evacuation du Centre, la poursuite des analyses radioactives et la decontamination du personnel. Pour cela, le Service de Protection contre les Radiations du Centre de Marcoule a mis sur pied des equipes mobiles de detection et realise une semi-remorque laboratoire ainsi qu'une semi-remorque douches. Apres avoir defini la mission des equipes mobiles, le rapport donne la description du materiel d'intervention qui serait mis en oeuvre par le Centre de Marcoule dans le cas d'un accident radioactif grave. Il precis le mode d'utilisation de ce materiel. (auteurs)

  16. {gamma}-spectroscopy and radioactive beams: search for highly deformed exotic nuclei; Detection {gamma} et faisceaux radioactifs: recherche de noyaux exotiques tres deformes

    Energy Technology Data Exchange (ETDEWEB)

    Rosse, B

    2006-07-15

    This work is devoted to the search for highly deformed nuclei under extreme conditions of isospin, located near the proton drip-line, around A {approx} 130. The experiment was performed at GANIL (Caen) with the SPIRAL radioactive beam facility. The nuclei of interest were produced by fusion-evaporation reactions induced by the neutron deficient Kr{sup 76} radioactive beam (T1/2 = 14.8 h). {gamma}-rays were detected by the EXOGAM array, composed of 11 segmented germanium clover detectors, for which a new segment calibration method has been developed. To extract fusion-evaporation events of a overwhelming background due to the radioactivity of the beam, the EXOGAM array was coupled with the light charged particle detector DIAMANT and the high acceptance VAMOS spectrometer. The latter was used for the first time to detect fusion-evaporation residues. The detailed data analysis allowed us to demonstrate that the EXOGAM + DIAMANT + VAMOS coupling is operational and essential to investigate the structure of these nuclei. Furthermore, the first {gamma} transition was observed in the very exotic odd-odd Pm{sup 130} nucleus. The results have been interpreted with static and dynamic self-consistent microscopic calculations in collaboration with the Theoretical Physicists of the IPN Lyon. (author)

  17. Desirable New Geologic Research in Support of Radioactive Waste Disposal as Indicated by Hanford Experience; Nouvelles Recherches Geologiques Souhaitables au Sujet de l'Elimination des Dechets Radioactifs, Selon les Indications Fournies par l'Experience de Hanford; 041f 0420 041e 0412 0415 0414 ; Nuevas Investigaciones Geologicas que Convendria Hacer para Facilitar la Evacuacion de Desechos Radiactivos Siguiendo las Indicaciones Proporcionadas por las Experiencias Efectuadas en Hanford

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Randall E. [Hanford Laboratories, Hanford Atomic Products Operation, General Electric Company, Richland, WA (United States)

    1960-07-01

    Hanford consiste a intercaler le plus grand nombre possible de structures geologiques entre les lieux d'elimination et les points les plus proches d'irradiation eventuelle des populations. Selon la decontamination de Simpson, ce procede fait appel aux notions de temporisation et de desintegration. Les problemes qui se posent a Hanford pour l'elimination des dechets portent sur les points suivants : - 1. l'inexactitude des donnees geologiques quantitatives; 2. l'absence de terrains isotropes et homogenes; 3. la necessite de determiner l'importance quantitative de l'ecart des caracteristiques geologiques et hydrologiques, par rapport a la jnpyexmejj ,4. la necessite de determiner et de mesurer les parametres interessants. Le memoire donne des exemples, pris a Hanford, qui illustrent les points ci-dessus. On a fore 557 puits d'une profondeur totale de 33.000 metres, mais les indications obtenues doivent etre utilisees avec prudence. Les etudes courantes des proprietes aquiferes des sols n'ont qu'une valeur limitee, car les donnees relatives a la permeabilite des differentes structures dans toutes les directions sont presentees globalement sous forme de valeurs moyennes. Les etudes fondees sur les echangea d'ions fournissent des donnees quantitatives d'un interet immediat qui peuvent aider a interpreter les caracteristiques geologiques. Les etudes hydrologiques, associees aux recherches geochimiques et aux donnees geologiques, permettent d'expliquer logiquement l'influence des structures geologiques sur les mouvements des eaux souterraines. L'enfouissement des dechets radioactifs n'est ni une panacee ni une pratique a redouter. A Hanford, en combinant les donnees obtenues par les geologues, les-hydrologistes, les geochimistes et les mathematiciens, on a pu parvenir a de bons resultats en matiere d'enfouissement sans danger des dechets. Il reste neanmoins beaucoup a faire. (author) [Spanish] La evacuacion de desechos radiactivos en el subsuelo depende de la estructura

  18. The treatment and conditioning of solid radioactive waste (1962); Le traitement et le conditionnement des dechets radioactifs solides (1982)

    Energy Technology Data Exchange (ETDEWEB)

    Cerre, P; Mestre, E [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    Previous studies, the results of which have been confirmed by experiments, have led us to build a semi-industrial plant for the treatment and coating of solid radioactive waste. This report details the means at our disposal in a pilot plant which, apart from being used for tests, was also routine-operated. It is thus possible to give also an appreciation of its operation in this report. (authors) [French] Les etudes anterieures, dont les resultats ont ete confirmes par des essais, nous ont conduits a realiser une installation semi-industrielle de traitement et d'enrobage des dechets radioactifs solides. Le rapport a pour but de preciser les moyens mis a notre disposition dans une unite pilote qui, outre son role de banc d'essai, a pu etre exploitee en routine. C'est donc aussi un bilan de son exploitation qui est presente. (auteurs)

  19. Analytical chemistry equipment for radioactive products; Installation de chimie analytique pour produits radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Douis, M; Guillon, A; Laurent, H; Sauvagnac, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1959-07-01

    The report deals with a shielded enclosure, hermetic, for analytical examination and handling of radioactive products. Remote handling for the following is provided: pipette absorption - weighing - centrifuging - desiccation - volumetric - pH measurement - potentiometric - colorimetric - polarographic. The above list is not restrictive: the enclosure is designed for the rapid installation of other equipment. Powerfully ventilated and screened to 400 m-curies long life fission product levels by 5 cm of lead, the enclosure is fully safe to the stated level. (author) [French] La presente communication decrit une enceinte etanche et blindee permettant un travail et un controle analytique sur des produits radioactifs. Les techniques suivantes sont adaptees pour une manipulation a distance: pipettage, pesees, centrifugation, dessiccation, volumetrie, mesure de pH, potentiometrie, colorimetrie, polarographie. Cette liste n'est pas limitative. La conception de l'installation permet la mise en place rapide d'autres appareils. Protegee par 5 cm de plomb et fortement ventilee, elle donne toute securite de manipulation jusqu'a un niveau d'activite 400 mcuries en produits de fission a vie longue. (auteur)

  20. Measurement of radioactive isotopes by {gamma} and x rays spectrometry with INa crystals. application to radiochemistry of some fission and activation products; Mesures d'isotopes radioactifs par spectrometrie {gamma} et x a l'aide de cristaux INa. application a la radiochimie de certains produits de fission et d'activation

    Energy Technology Data Exchange (ETDEWEB)

    Simonet, P; Boile, G; Simonet, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-07-01

    The measurement of an number of atoms N may be obtained by detection of one {gamma} ray emitted if its branching ratio K{sub E} is known (number of E energy {gamma} transitions/number of disintegrations). N = A/{lambda} N{sub {gamma}}{sub E} / (K{sub E} * {lambda}) This measurement is effectuated in well-defined geometry, {gamma} rays emitted by the source are detected by a calibrated NaI crystal which is connected to a photomultiplier delivering electric impulses analysed by a multichannel analyser. Crystals are chosen according to energy, intensity of measured rays and of background. Calibration is established with standard sources or by total absolute efficiency of a definite crystal. Half-life, energy of measured photopeak branching ratio have been determined for these isotopes: Fission products: {sup 95}Zr, {sup 95}Nb, {sup 99}Mo, {sup 103}Ru, {sup 106}Ru, {sup 111}Ag, {sup 115}Cd, {sup 115m}Cd, {sup 132}Te, {sup 129m}Te, {sup 134}Cs, {sup 136}Cs, {sup 137}Cs, {sup 140}Ba, {sup 140}La. Rare earth elements: {sup 91}Y, {sup 141}Ce, {sup 144}Ce, {sup 147}Nd, {sup 156}Eu. Products from reactions (n, {gamma}) (n, 2n): 1{sup 10}Ag, {sup 124}Sb, {sup 239}Np, {sup 237}U, {sup 241}Am. (authors) [French] La mesure du nombre d'atomes N d'un isotope peut s'effectuer sur un rayonnement {gamma} si l'on connait le rapport d'embranchement K{sub E} (nombre de rayonnements {gamma} d'energie E/nombre de desintegrations). N = A/{lambda} N{sub {gamma}}{sub E} / (K{sub E} * {lambda}) La mesure s'effectue en geometrie definie; les rayonnements {gamma} emis par la source sous mylar sont detectes par un cristal INa etalonne en fonction de l'energie, lequel est relie a un photomultiplicateur delivrant des impulsions electriques qui seront analysees par un selecteur multicanaux. La connaissance de la distribution theorique (effet photoelectrique, compton, paires, retrodiffusion, echappement... ) permet de determiner qualitativement si les elements sont purs, et de faire une mesure sur

  1. Study of radio-active ions in the atmosphere; Etude des ions radioactifs de l'atmosphere

    Energy Technology Data Exchange (ETDEWEB)

    Renoux, A [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1965-01-01

    A comparative study is made of active, deposits of radon and thoron in suspension in the atmosphere by means of {alpha} radiation counting, using ZELENY tubes, scattering equipment, filter papers or membranes. It has been possible to show the existence of small and large ions which are negative and positive, as well as of neutral radio-active nuclei; their properties are studied. A theoretical interpretation of the results is presented. The average content of radon (using the Ra A concentration) and of Th B in the air has been determined. The radioactive equilibrium between radon and its daughter products in atmospheric air are examined. The techniques developed for active radon and thoron deposits are applied to the study of artificial radio-activity, the analyses being carried out by means of {gamma} spectrometry. (author) [French] On effectue une etude comparative entre les depots actifs du radon et du thoron en suspension dont l'atmosphere a l'aide de comptages de rayonnement {alpha}, en utilisant des tubes de ZELENY, une batterie de diffusion, des papiers filtres ou des membranes. On met ainsi en evidence la presence de petits et gros ions negatifs et positifs, ainsi que celle de noyaux neutres radioactifs, et on etudie leurs proprietes. Une Interpretation theorique des resultats obtenus est developpee. On determine la teneur moyenne de l'air en radon (a partir de la concentration en Ra A) et en Th B. L'equilibre radioactif entre le radon et ses descendants, dans l'air atmospherique, est examine. Les Techniques mises au point pour les depots actifs du radon et du thoron sont appliquees a l'etude de la radioactivite artificielle, les depouillements s'effectuant par spectrometrie {gamma}. (auteur)

  2. Radio-tracer techniques in the study of corrosion by molten fluorides; Etude, a l'aide d'indicateurs radioactifs, de la corrosion provoquee par les fluorures fondus; Primenenie metodov radioaktivnykh indikatorov nrn izuchenii korrozii, prichinyaemoj rasplavlennymi ftoristymi soedineniyami; Estudio con indicadores radiactivos de la corrosion ocasionada por fluoruros fundidos

    Energy Technology Data Exchange (ETDEWEB)

    Grimes, W R; Watson, G M; DeVan, J H; Evans, R B [Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    1962-03-15

    de fluorures fondus contenant, des substances reductibles, le chrome est oxyde selectivement et elimine de l'alliage. En utilisant comme radioindicateur le chrome-51, les auteurs du memoire ont evalue les coefficients d'autodiffusion du chrome dans l'Inconel et l'Inor-8 et verifie dans quelle mesure les valeurs obtenues sont applicables aux alliages exposes a la corrosion. Les auteurs ont calcule les coefficients globaux: 1) en mesurant le passage du chrome-51 (employe sous forme de CrF{sub 2}) des capsules d'alliage aux fluorures non corrosifs fondus; 2) en comparant la radioactivite totale mesuree des echantillons d'alliage exposes avec celle du sel auquel ils avaient ete exposes. Ils ont calcule en outre des coefficients en mesurant les profils de concentration de l'indicateur par polissages electrolytiques successifs des echantillons. Les coefficients globaux et ceux qui ont ete obtenus par polissage electrolytique concordent parfaitement pour l'Inconel a des temperatures elevees et pour l'Inor-8 a toutes les temperatures. Pour les temperatures inferieures a 750{sup o}C, les coefficients obtenus par polissage electrolytique de l'Inconel sont superieurs aux coefficients globaux; dans ce cas, le processus de diffusion dans la masse n'est pas uniforme. Il y a toujours concordance satisfaisante entre les coefficients globaux de diffusion et les coefficients obtenus par extrapolation des donnees publiees au sujet d'alliages Cr-Ni generalement analogues, a des temperatures plus elevees. Les auteurs se sont servis de deux anneaux polythermiques d'Inor-8 pour faire circuler une masse de fluorures fondus non corrosifs contenant du chrome-51 (sous forme de CrF{sub 2}). Ils ont sacrifie l'un des circuits pour evaluer la quantite de {sup 51}Cr absorbee par l'alliage, et utilise l'autre pour faire circuler un melange fondu contenant du FeF{sub 2} et mesurer l'elimination du chrome de l'alliage. Les resultats obtenus concordent assez, bien avec les donnees fournies par les

  3. The treatment of effluents; Ameliorations apportees aux traitements des residus radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Wormser, G; Rodier, J; Robien, E de; Fernandez, N [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1964-07-01

    resins are used in the sodium form; the regeneration is carried out using a sodium salt solution which, after decontamination by coprecipitation is used again. With this process it is possible to use a smaller volume of sludge. 2 - The use of a natural evaporator. This process uses atmospheric air which is not saturated with water vapour and which is at a normal temperature, in order to extract water from the aqueous effluents. (authors) [French] Depuis plusieurs annees, le Commissariat a l'Eneregie Atomique Francais s'est penche avec interet sur les problemes poses par les effluents radioactifs. Les hautes activites n'ayant pas encore recu de solution definitive, nous nous bornerons a traiter, dans cette communication, que des realisations et des recherches relatives aux effluents faiblement et moyennement actifs. Dans le domaine des realisations, diverses stations de traitement ont ete construites en France; nous en ferons une breve enumeration, tout en faisant ressortir les nouveautes les plus importantes. C'est ainsi que nous presenterons plus specialement les dernieres stations de traitement mises en oeuvre (Grenoble, Fontenay-aux-Roses, Cadarache). De I'ensemble de ces realisations nouvelles, nous traiterons d'une maniere un peu plus approfondie, les trois sujets suivants: 1 - Atelier de conditionnement par bitumage des boues provenant de la concentration des radio-nucleides. 2 - Atelier de traitement des dechets solides radioactifs et combustibles par incineration. 3 - Ensemble de concentration effluents liquides radioactifs par evaporation. Dans le domaine de la recherche, de nombreuses voies ont ete abordees; nous en ferons I'inventaire. Il s'agit, dans la plupart des cas, de la concentration des radio-nucleides en vue d'un stockage pratique et peu onereux, concentration associee a une decontamination efficace, et Ie meilleur marche possible, des liquides aqueux, en vue de leur rejet. Pour l'amelioration des traitements aboutissant a la concentration des radio

  4. A new class of medicament: radioactivity isotopes (1962); Une nouvelle classe de medicaments: les isotopes radioactifs (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Y. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    Very many radioelement are used in medicine, either for diagnosis or as therapeutics. The development of medicine has entailed an increase in the number of application of radioactive isotopes. Firstly used in the form of simple inorganic molecules for diagnosis or as anticancer therapeutics, radioelements are now used for labelling organic molecules, allowing functional specific studies of any kind of nature. Their production is made difficult by their radio-active properties. Their pharmaceutical properties, determined by tests and controls, depend either from radiochemistry and from medicine. The author reminds, in this report, the methods for the preparation and analysis, and set out the medical application. (author) [French] De tres nombreux radioelements trouvent une application en medecine humaine, soit dans le diagnostic, soit en therapeutique. L'evolution de la medecine entraine un accroissement du champ d'application des isotopes radioactifs. D'abord utilises sous forme de molecules minerales simples, pour les diagnostics ou des therapeutiques anticancereuses, les radioelements sont maintenant introduits dans des molecules organiques qui permettent des etudes fonctionnelles specifiques de toute nature. Leur fabrication est compliquee par leurs proprietes radioactives. Leurs caracteristiques pharmaceutiques determinees par des essais et controles, sont liees d'une part a la radiochimie, d'autre part a la medecine. L'auteur rappelle, dans cet expose, les methodes de preparation et d'analyse et aborde les applications medicales. (auteur)

  5. A new class of medicament: radioactivity isotopes (1962); Une nouvelle classe de medicaments: les isotopes radioactifs (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Y [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    Very many radioelement are used in medicine, either for diagnosis or as therapeutics. The development of medicine has entailed an increase in the number of application of radioactive isotopes. Firstly used in the form of simple inorganic molecules for diagnosis or as anticancer therapeutics, radioelements are now used for labelling organic molecules, allowing functional specific studies of any kind of nature. Their production is made difficult by their radio-active properties. Their pharmaceutical properties, determined by tests and controls, depend either from radiochemistry and from medicine. The author reminds, in this report, the methods for the preparation and analysis, and set out the medical application. (author) [French] De tres nombreux radioelements trouvent une application en medecine humaine, soit dans le diagnostic, soit en therapeutique. L'evolution de la medecine entraine un accroissement du champ d'application des isotopes radioactifs. D'abord utilises sous forme de molecules minerales simples, pour les diagnostics ou des therapeutiques anticancereuses, les radioelements sont maintenant introduits dans des molecules organiques qui permettent des etudes fonctionnelles specifiques de toute nature. Leur fabrication est compliquee par leurs proprietes radioactives. Leurs caracteristiques pharmaceutiques determinees par des essais et controles, sont liees d'une part a la radiochimie, d'autre part a la medecine. L'auteur rappelle, dans cet expose, les methodes de preparation et d'analyse et aborde les applications medicales. (auteur)

  6. Dating methods based on the radioactive disequilibrium (1961); Methodes de chronologie par le desequilibre radioactif (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Coquema, C; Coulomb, R; Goldsztein, M; Schiltz, J C [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1961-07-01

    The existence in the uranium families of two long-life descendants: ionium (half-life 80000 years) and protactinium (half-life 32000 years), together with the differences in geochemical behaviour of the various natural radio-elements, particularly thorium, make it possible to envisage several models of geological time-scales covering-periods from 0 to 500000 years The theory of two of the most important models i s developed and methods are described for making radiochemical measurements on the various nuclides which are essential for resolving these models (U{sup 238}, Th{sup 234}, Th{sup 230}, Ra{sup 226}, Pa{sup 231}, Th{sup 232}, Th{sup 228}, Po{sup 210}) An example of dating is given in the case of a secondary mineralisation on a weathered portion of a deposit in the Limouzat (Forez). Samples of autunite and chalcolite taken at different levels of the mine were calculated to be between 30000 and 240000 years old. (authors) [French] L'existence dans les familles de l'uranium de deux descendants a vie longue: ionium (periode 80000 ans) et protactinium (periode 32000 ans), ainsi que les differences tie comportement geochimique des divers radioelements naturels, en particulier du thorium, permettent d'envisager plusieurs modeles d'echelles geochronologiques couvrant un domaine allant de 0 a 500000 ans. Nous developpons la theorie de deux de ces modeles les plus importants, et decrivons les methodes de dosage radiochimiques des divers nucleides dont la connaissance est necessaire a la resolution des modeles ({sup 238}U, {sup 234}Th, {sup 230}Th, {sup 226}Ra, {sup 231}Pa, {sup 232}Th, {sup 228}Th, {sup 210}Po). On donne un exemple de chronologie d'une mineralisation secondaire sur la partie alteree du gisement du Liznouzat (Forez). Des echantillons d'autunite et de chalcolite pris a differents niveaux de la mine ont pu etre dates de 30000 a 240000 ans. (auteurs)

  7. Code of Practice on the International Transboundary Movement of Radioactive Waste; Code De Bonne Pratique Sur Le Mouvement Transfrontiere International De Dechets Radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1990-11-03

    On 21 September 1990, the General Conference, by resolution GC(XXXIV)/RES/530, adopted a Code of Practice on the International Transboundary Movement of Radioactive Waste and requested the Director General - inter alia - to take all necessary steps to ensure wide dissemination of the Code of Practice at both the national and the international level. The Code of Practice was elaborated by a Group of Experts established pursuant to resolution GC(XXXII)/RES/490 adopted by the General Conference in 1988. The text of the Code of Practice is reproduced herewith for the information of all Member States [French] Le 21 septembre 1990, la Conference generale, par la resolution GC(XXXIV)/RES/530, a adopte le Code de bonne pratique sur le mouvement transfrontiere international de dechets radioactifs et a prie le Directeur general-notamment-de prendre toutes les mesures necessaires pour assurer une large diffusion du Code de bonne pratique aux niveaux tant national qu'international. Le Code de bonne pratique a ete elabore par un groupe d'experts cree en application de la resolution GC(XXXII)/RES/490 adoptee par la Conference generale en 1988. Le texte du Code de bonne pratique est reproduit ci-apres pour l'information de tous les Etats Membres.

  8. Determination of the concentration of {alpha} emitting radioactive aerosols; Mesure de la concentration des aerosols radioactifs emetteurs {alpha}

    Energy Technology Data Exchange (ETDEWEB)

    Labeyrie, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1953-06-15

    In the first part of this work the techniques used for the quantitative measurement of the concentrations of aerosols carrying short lived (radon or thoron daughters) or long lived (uranium) {alpha} radioactive emitters are described. In the second part the author investigates the problem of the determination of radon concentration in air by means of activity determinations on airborne dusts. Special reference is made to the measurement of the radon active deposit on two types of dusts (iron oxide (yellow) and uranium oxide) in small chambers (6 liters). In the third part are given data resulting from determinations of radon and thoron concentrations in atmospheric air in the south of Paris area using this method. (author) [French] Dans la premiere partie de ce travail on expose les techniques utilisees pour la mesure quantitative des concentrations d'aerosols contenant des emetteurs radioactifs {alpha}, tant pour ceux a vie courte (derives du radon ou du thoron) que pour ceux a vie longue (uranium). Dans la seconde partie on traite le probleme de la determination de la concentration de l'air en radon par la mesure de l'activite des poussieres ayant sejourne dans cet air. En particulier, on indique pour de petits volumes (6 litres) la proportion de depot actif du radon qui est fixee sur deux types de poussieres (limonite et oxyde d'uranium) en fonction de la concentration de celles-ci. Dans la troisieme partie on donne quelques exemples de mesure par cette methode de la concentration en radon et en thoron de l'atmosphere de la region parisienne. (auteur)

  9. Study of filterable materials and protection instruments by the use of radioactive aerosols; Etude de materiaux filtrants et d'appareils de protection a l'aide des aerosols radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Billard,; Chevalier,; Pradel, [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    Many filtration problems can be studied by means of radioactive aerosols. For the investigations described in this paper we have chosen the solid disintegration products of radon, the radioactive gas formed from radium, because of the facilities of generation and measurement it offers. Radon and its daughters are in fact always present in the atmosphere in sufficient concentration for certain tests. In order to improve the sensitivity of the measurements, radon from uranium ore can be used. The technique of measuring by counting {alpha} particles is rapid and easy to employ. We have thus been able to define a test for filterable substances, and to check filtering installation and individual protection instruments. (author) [French] Les aerosols radioactifs permettent d'etudier de nombreux problemes de filtration. Pour les etudes decrites dans ce document, nous avons choisi les produits solides de desintegration du radon, gaz radioactif forme a partir du radium en raison des facilites de generation et de mesure. Le radon et ses descendants sont, en effet, toujours presents dans l'atmosphere en concentration suffisante pour certains essais. Pour ameliorer la sensibilite des mesures, il suffit d'utiliser le radon provenant de minerai d'uranium. La technique de mesure par comptage des particules {alpha} est rapide et facile a mettre en oeuvre. Nous avons pu ainsi definir un test pour les substances filtrantes et controler les installations de filtration et des appareils de protection individuelle. (auteur)

  10. Production of fast neutrons from deuteron beams in view of producing radioactive heavy ions beams; Etude de la production de neutrons rapides a partir de faisceaux de deutons en vue de la mise en oeuvre de faisceaux d'ions lourds radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Pauwels, N

    2000-11-01

    This thesis is part of two research and development programmes for the study of neutron rich radioactive nuclear beam production. The technique is based on the ISOL method and can be summarized as follows. Fast neutrons are generated by the break-up of deuterons in a thick target. These neutrons irradiate a fissionable {sup 238}U target. The resulting fission products are extracted from the target, ionised, mass selected and post-accelerated. The aim of the thesis is to study the neutron angular and energetic distributions. After a bibliographical research to justify the choice of deuterons as the best projectile, we developed more specifically three points: - the extension of the activation detector method for neutron spectroscopy to a wide energy range (1 to 150 MeV), - the experimental measurement of neutron angular and energetic distributions produced by deuterons on thick targets. The deuteron energy ranges from 17 to 200 MeV and the thick targets were Be, C and U, - the realization of a code based on Serber's theory to predict the neutron distribution for any couple (deuteron energy-thick target). We conclude that for our application the most suitable target is C and the best deuteron energy is about 100 MeV. (author)

  11. The Treatment of Cancer by a Radioactive Drug: Tritium-Labelled Tetra-Sodium 2-Methyl-1:4-Naphthaquinol Diphosphate; Traitement du Cancer par un Remede Radioactif: Le Diphosphate Tetrasodique de Methyl-2 Naphtoquinone-1,4 Tritie; 041b 0435 0447 0435 043d 0414 ; Tratamiento del Cancer con la Sal Tetrasodica del Acido 2-Metil-1,4-Naftoquinon Difosforico Marcada con Tritio

    Energy Technology Data Exchange (ETDEWEB)

    Marrian, D. H.; Marshall, Barbara; Mitchell, J. S.; Simon-Reuss, I. [Department of Radiotherapeutics, University of Cambridge, Cambridge (United Kingdom)

    1962-02-15

    The action of tetra-sodium 2-methyl-1: 4-naphthaquinoI diphosphate (''Synkavit''-Roche Products) as a radiosensitizer will be reviewed together with earlier methods of labelling this and similar molecules. The synthesis of this compound labelled with tritium has been accomplished so as to yield a radiochemically pure drug of specific activity 28 c/mmole (1 atom of tritium/molecule). It will be shown that this compound enters the living cell very rapidly both in-vivo and in-vitro and that cultures of malignant cells incorporate the label to a much greater extent than cultures of normal cells under identical conditions. Preliminary investigations on the use of this drug on patients with advanced, and often otherwise, refractory, malignant conditions will be described; uptake by the bone marrow is less than by the tumour, sometimes by a factor of 5. (author) [French] Les auteurs examinent l'action du diphosphate tetrasodique de methyl-2- naphtoquinone-1,4 ('Synkavit'-Produits Roche) comme radiosensibilisateur, ainsi que les methodes plus anciennes de marquage de ces molecules et de molecules analogues. On a fait la synthese de ce compose marque au tritium, de facon a obtenir un produit pharmaceutique radiochimiquement pur, dont l'activite specifique est de 28 curies par millimole (1 atome de tritium par molecule). Les auteurs demontrent que ce compose penetre tres rapidement dans la cellule vivante, tant in vivo qu'in vitro, et que les cultures de cellules malignes fixent l'indicateur dans une mesure beaucoup plus large que ne le feront les cellules normales dans les memes conditions. Les auteurs exposent les resultats de recherches preliminaires sur l'emploi de ce remede pour soigner des malades atteints de tumeurs malignes avancees et souvent refractaires a tout autre traitement. L'absorption par la moelle osseuse est inferieure, parfois de 5 fois, a l'absorption par la tumeur. (author) [Spanish] Los autores describen la accion radiosensibilizadora de la sal

  12. The Determination of Components of Radioactive Decay Mixtures by Computer Analysis of Count-Rate Data; Determination des Composants de Melanges Radioactifs en Decroissance par Analyse a l'Ordinateur des Resultats du Comptage; Opredelenie komponentov smesej radioaktivnogo raspada posredstvom analiza dannykh skorostej scheta s pomoshch'yu schetno-reshayushchego ustrojstva; Determinacion de los Componentes de Mezclas Radiactivas por Analisis de los Datos de Recuento Mediante Calculadoras

    Energy Technology Data Exchange (ETDEWEB)

    Airman, W. D.F.; Tyler, S. A.; Dipertand, M. H.; Sedlet, J. [Argonne National Laboratory, Argonne, IL (United States)

    1965-10-15

    measurements are made permit correlations between the data obtained and the total decay and growth rates. The development of the programme and the results obtained from theoretical and experimental data used to test it are discussed. (author) [French] Les composants d'un melange de n radioisotopes peuvent etre determines d'apres les variations de l'activite avec le temps, a condition que l'activite d'au moins n-1 elements se modifie de maniere appreciable au cours de la periode consideree, soit par la decroissance directe, soit par la croissance des produits de desintegration. Pour chaque melange, il est possible de predire un ensemble d'elements d'apres des facteurs tels que l'origine et l'evolution anterieure du melange et les techniques de separation chimique et de comptage utilisees. Si ces facteurs sont appliques de maniere convenable, l'ensemble suppose contiendra tous les elements que comporte effectivement le melange. On peut alors, soit formuler les equations de croissance ou de decroissance et les resoudre simultanement pour obtenir chaque element, soit determiner le melange sous forme graphique par extrapolation des parties lineaires de la courbe totale decroissance-croissance. Toutefois, lorsque le nombre d'elements est eleve ou que des schemas complexes de decroissance entrent en ligne de compte, il est impossible, soit d'appliquer l'une ou l'autre de ces techniques, soit d'evaluer les erreurs inherentes aux previsions. L'application de la methode des moindres carres permet d'identifier plus exactement les elements en decroissance que la methode consistant a n'utiliser que des equations simultanees. Les auteurs ont donc mis au point un programme d'ordinateur Fortran, fonde sur la methode des moindres carres (designe par le vocable CORD) et destine a resoudre le probleme general, a savoir: etant donne le taux de comptage pour un echantillon, les precurseurs et les schemas de decroissance possibles, toutes les constantes de decroissance et les caracteristiques de

  13. Modifications of the laser beam coherence inertial confinement fusion plasmas; Modifications des proprietes de coherence des faisceaux laser dans les plasmas de fusion par confinement inertiel

    Energy Technology Data Exchange (ETDEWEB)

    Grech, M

    2007-06-15

    Inertial confinement fusion by laser requires smoothed laser beam with well-controlled coherence properties. Such beams are made of many randomly distributed intensity maxima: the so-called speckles. As the laser beam propagates through plasma its temporal and spatial coherence can be reduced. This phenomenon is called plasma induced smoothing. For high laser intensities, instabilities developing independently inside the speckles are responsible for the coherence loss. At lower intensities, only collective effects, involving many speckles, can lead to induced smoothing. This thesis is a theoretical, numerical and experimental study of these mechanisms. Accounting for the partially incoherent behavior of the laser beams requires the use of statistical description of the laser-plasma interaction. A model is developed for the multiple scattering of the laser light on the self-induced density perturbations that is responsible for a spreading of the temporal and spatial spectra of the transmitted light. It also serves as a strong seed for the instability of forward stimulated Brillouin scattering that induces both, angular spreading and red-shift of the transmitted light. A statistical model is developed for this instability. A criterion is obtained that gives a laser power (below the critical power for filamentation) above which the instability growth is important. Numerical simulations with the interaction code PARAX and an experiment performed on the ALISE laser facility confirm the importance of these forward scattering mechanisms in the modification of the laser coherence properties. (author)

  14. Collection and processing of information in biological kinetics studies with radioactive tracers; Collecte et traitement de l'information dans les etudes de cinetique biologique avec traceurs radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Remy, J; Lafuma, J [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    The authors present an automatic method for the collection and treatment of information in biological kinetics experiments using radioactive tracers. The recording are made without any time constant on magnetic tape. The information recorded is sampled by a 400 channel multi-scale analyzer and transferred to punched cards. The digital analysis is done by an I.B.M. computer. The method is illustrated by an example: the hepatic fixation of colloidal gold in the pig. Its advantages and requirements are discussed. In the appendix are given the FORTRAN texts for two programmes used in treating the example presented. (authors) [French] Les auteurs presentent une methode automatique de collecte et de traitement de l'information dans les experiences de cinetique biologique utilisant les traceurs radioactifs. Les enregistrements sont realises sans constante de temps sur bande magnetique. L'information enregistree fait l'objet d'un echantillonnage a l'aide d'un analyseur a 400 canaux en mode multi-echelle puis est transferee sur cartes perforees. L'exploitation digitale est confiee a un ordinateur I.B.M.. La methode est illustree par un exemple d'etude de la fixation hepatique de l'or colloidal chez le porc. Ses avantages et ses exigences sont discutes. En annexe figurent les textes en FORTRAN de deux programmes utilises pour le traitement de l'exemple cite. (auteurs)

  15. Experimental study of heat transfer for parallel flow in tube bundles with constant heat flux and for medium Prandtl numbers; Etude experimentale du transfert de chaleur dans des faisceaux tubulaires en ecoulement parallele pour une densite de flux thermique constante dans le domaine des nombres de Prandtl moyens

    Energy Technology Data Exchange (ETDEWEB)

    Rieger, M [Commissariat a l' Energie Atomique, 91 - Saclay (France). Centre d' Etudes Nucleaires

    1968-06-01

    The heat transfer parameters were determined experimentally in electrically heated tube bundles for turbulent flow parallel to the axis. The tubes were arranged in a pattern of equilateral triangles. The ratios of the distance between the axes of the tubes to their external diameter were 1.60 and 1.25 in the two test sections studied. The experiments were carried out with distilled water and with a mixture of 60 per cent ethylene glycol and 40 per cent water. The values obtained for the Prandtl numbers in this way fell within the range from 2.3 to 18. The Reynolds numbers were varied between 10{sup 4} and 2.10{sup 5}. The relation between the mean heat transfer coefficients and the friction factor in the tube bundles was found from the experiments as: Nu = [Re Pr {zeta}/8]/[1+{radical}({zeta}/8) 8.8 (Pr-1.3) Pr{sup -0.22}]. The experimentally determined mean Nusselt numbers were also given by the following function: Nu = (0.0122 + 0.00245 p/d) Re{sup 0.86} Pr{sup 0.4}, with a maximum deviation of {+-}4 per cent. For certain local Nusselt numbers, deviations of up to 20 per cent with respect to the relations given were observed. (author) [French] Dans des faisceaux tubulaires a chauffage electrique parcourus par un ecoulement turbulent parallele a l'axe, on a determine experimentalement les parametres du transfert de chaleur. Les centres des sections droites des tubes etaient des sommets de triangles equilateraux. Les rapports de la distance a l'axe des tubes et leur diametre exterieur dans les deux veines de mesure etudiees etaient de 1.60 et 1.25. Des essais furent effectues avec de l'eau distillee ainsi qu'avec un melange de 60 pour cent de glycol ethylenique et 40 pour cent d'eau. Les valeurs des nombres de Prandtl obtenues ainsi etaient situees entre 2.3 a 18. On a fait varier les nombres de Reynolds entre 10{sup 4} et 2.10{sup 5}. La relation entre les nombres caracteristiques de transfert de chaleur moyens et la perte de charge dans les faisceaux tabulaires

  16. Study of the behaviour of artificial radioactive aerosols. Applications to some problems of atmospheric circulation (1963); Etude du comportement dcs aerosols radioactifs artificiels. Applications a quelques problemes de circulation atmospherique (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, G. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-11-15

    The aim of this work, consists in the examination of the behaviour of radioactive aerosols produced in the atmosphere by nuclear explosions, in order to deduce the most general laws governing atmospheric circulation and diffusion. After having given a general table of the radioactive aerosols present the authors consider the validity and the precision of the measurement methods and the concentration of the aerosols at ground level and in the upper atmosphere, as well as their deposition on the ground. The existence is thus demonstrated of a tropospheric equatorial barrier and of discontinuous and seasonal aspects of stratosphere-troposphere transfers. The role is shown of precipitations and dry auto-filtration in the lower atmosphere cleaning processes. This work makes it possible to describe the general behaviour of dust from the stratosphere, and to improve the total radioactive contamination of the globe. (author) [French] L'objectif de ce travail consiste a examiner le comportement des aerosols radioactifs introduits dans l'atmosphere par les explosions nucleaires, pour en deduire les lois les plus generals de la circulation et diffusion atmospheriques. Apres avoir dresse un tableau d'ensemble des aerosols radioactifs presents, on examine la validite et la precision des methodes de mesure de leur concentration, au niveau du sol et en haute atmosphere, ainsi que de leur depot a la surface du sol. On met ainsi en evidence l'existence d'une barriere equatoriale tropospherique; l'aspect discontinu et saisonnier des transferts stratosphere-troposphere; le role des precipitations et de l'auto-filtration seche, dans les processus de nettoyage de la basse atmosphere. Ces etudes permettent de decrire le comportement general des poussieres d'origine stratospherique et d'ameliorer le bilan de la contamination radioactive du globe. (auteur)

  17. Study of the behaviour of artificial radioactive aerosols. Applications to some problems of atmospheric circulation (1963); Etude du comportement dcs aerosols radioactifs artificiels. Applications a quelques problemes de circulation atmospherique (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-11-15

    The aim of this work, consists in the examination of the behaviour of radioactive aerosols produced in the atmosphere by nuclear explosions, in order to deduce the most general laws governing atmospheric circulation and diffusion. After having given a general table of the radioactive aerosols present the authors consider the validity and the precision of the measurement methods and the concentration of the aerosols at ground level and in the upper atmosphere, as well as their deposition on the ground. The existence is thus demonstrated of a tropospheric equatorial barrier and of discontinuous and seasonal aspects of stratosphere-troposphere transfers. The role is shown of precipitations and dry auto-filtration in the lower atmosphere cleaning processes. This work makes it possible to describe the general behaviour of dust from the stratosphere, and to improve the total radioactive contamination of the globe. (author) [French] L'objectif de ce travail consiste a examiner le comportement des aerosols radioactifs introduits dans l'atmosphere par les explosions nucleaires, pour en deduire les lois les plus generals de la circulation et diffusion atmospheriques. Apres avoir dresse un tableau d'ensemble des aerosols radioactifs presents, on examine la validite et la precision des methodes de mesure de leur concentration, au niveau du sol et en haute atmosphere, ainsi que de leur depot a la surface du sol. On met ainsi en evidence l'existence d'une barriere equatoriale tropospherique; l'aspect discontinu et saisonnier des transferts stratosphere-troposphere; le role des precipitations et de l'auto-filtration seche, dans les processus de nettoyage de la basse atmosphere. Ces etudes permettent de decrire le comportement general des poussieres d'origine stratospherique et d'ameliorer le bilan de la contamination radioactive du globe. (auteur)

  18. Some examples of the use of radioactive tracers in pharmacodynamic; Quelques exemples de l'emploi des traceurs radioactifs en pharmacodynamie

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Y [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    The study of absorption, of distribution in the organism and of the elimination of a medicament has been greatly facilitated by the development of nuclear applications. In effect, the introduction into the molecule of one or several radioactive atoms makes it possible to follow the path and destination of minute quantities of the drug and to thus carry out analyses on the animal within limits of posology close to those of therapeutics. However the qualitative or quantitative methods used have certain limits and they must be compared amongst themselves and with others. Some examples will show : - the importance of the way of administering the drug on the changes in the distribution; - the quite relative selectivity of this latter; - and lastly, the different process involved in the elimination mechanisms. (author) [French] L'etude de l'absorption, de la repartition dans l'organisme et de l'elimination d'un medicament s'est trouvee grandement facilitee par le developpement des applications nucleaires. En effet, l'introduction dans une molecule d'un ou plusieurs atomes radioactifs permet de suivre le sort de quantites infimes de la drogue et de ce fait d'en effectuer l'analyse chez l'animal dans des limites de posologie se rapprochant de celles de la therapeutique. Cependant les methodes employees, qualitatives ou quantitatives, presentent des limites et doivent etre confrontees entre elles et avec d'autres methodes. Quelques exemples mettront en evidence: - l'importance du mode d'administration sur l'evolution de la repartition, - l'electivite toute relative de cette derniere, - et enfin, les modalites diverses des mecanismes d'elimination. (auteur)

  19. Results of concentration measurements of artificial radioactive aerosols in the lower atmosphere; Resultats des mesures de concentration, dans la basse atmosphere, des aerosols radioactifs artificiels

    Energy Technology Data Exchange (ETDEWEB)

    Ardouin, B; Jehanno, C; Labeyrie, J; Lambert, G; Tanaevsky, O; Vassy, E [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-07-01

    This report gives the results of the measurements of artificial gross-{beta}-radioactivity in aerosols in the lower atmosphere; these measurements have been made by the Electronic Physics Service of the Electronic Department, and by the Atmospheric Physics Laboratory of the Paris Science Faculty. The measurements were begun in September 1956 and were continued in an increasing number of stations both in France and in the rest of the world. The present report deals with the period up to the end of august 1961, that is up to the end of the nuclear moratorium. After recalling the constitution and the properties of radioactive aerosols present in the atmosphere, the authors describe the measurement methods, estimate their accuracy and discuss various aspects of the results. (authors) [French] Ce rapport contient les resultats des mesures de radioactivite {beta} globale d'origine artificielle des aerosols dans la basse atmosphere, effectuees conjointement par le Service d'Electronique Physique du Departement d'Electronique et le Laboratoire de Physique de l'Atmosphere de la Faculte des Sciences de Paris. Les mesures ont commence en septembre 1956 et ont ete poursuivies dans un nombre croissant de stations, tant en France que dans le reste du monde. Le present rapport s'arrete a la fin aout 1961, c'est-a-dire au moment de la reprise des essais nucleaires. Apres avoir rappele la constitution et les proprietes des aerosols radioactifs presents dans l'atmosphere, les auteurs indiquent les methodes de mesure utilisees, evaluent leur precision et discutent les differents aspects des resultats de leurs mesures. (auteurs)

  20. Testing and calibration through laser radiation and muon beams of the hadron calorimeter in ATLAS detector; Controle et etalonnage par lumiere laser et par faisceaux de muons du calorimetre hadronique a tuiles scintillantes d'ATLAS

    Energy Technology Data Exchange (ETDEWEB)

    Garde, V

    2003-10-15

    This study is dedicated to the calibration of the hadronic calorimeter (Tilecal) of the ATLAS detector. This detector will be installed on the LHC collider at CERN. The first data will be taken in 2007. This thesis is divided in two parts. The first part is dedicated to the study of the LASER system. A prototype of the final system was studied. It was shown that the stability and the linearity of this prototype are conform to the specification. Several studies were devoted to measurements which can be done on the Tilecal: The relative gain can be calculated and gives the stability of the Tilecal with a resolution of 0.35 %. The number of photoelectrons per charge unit has been calculated. The linearity was checked for a normal range of functioning and was corrected for the functioning at high charge. In both cases it was shown that the non-linearity was smaller than 0.5 %. The second study is devoted to muons beams in test beam periods. These results are used to find a calibration constant. Several problems which come from the difference of size cells are not totally solved. But the resolution of the calibration constant found by this method cannot exceed 2.3%. (author)

  1. Radioactive beams produced by the ISOL method: development for laser ionization and for surface ionization; Faisceaux exotiques par methode ISOL: developpements pour l'ionisation par laser et l'ionisation de surface

    Energy Technology Data Exchange (ETDEWEB)

    Hosni, Faouzi

    2004-10-01

    The works were carried out in the framework of the research program PARRNe (production of radioactive neutron-rich nuclei). This program aims to determine optimal conditions to produce intense beams of neutron-rich isotopes. This thesis treats multiple technical aspects related to the production of separate radioactive isotopes in line (ISOL). It deals mainly with the development of the target-source unit which is the key element for projects such as SPIRAL-2 or EURISOL.The first part presents the various methods using fission as production mode and compares them: fission induced by thermal neutrons, induced by fast neutrons and photofission. The experiment carried out at CERN validated the interest of the photofission as a promising production mode of radioactive ions. That is why the institute of nuclear physics of Orsay decided to build a linear electron accelerator at the Tandem d'Orsay (ALTO).The second part of this thesis deals with the development of uranium targets. The X-rays diffraction and Scanning Electron Microscopy have been used as analysis techniques. They allowed to determine the chemical and structural characteristics of uranium carbide targets as function of various heating temperatures. After the production, the process of ionization has been studied. Two types of ion source have been worked out: the first one is a surface ion source and the second one is a source based on resonant ionization by laser. These two types of sources will be used for the ALTO project. (author)

  2. Study of the production of neutron-rich isotope beams issuing from fissions induced by fast neutrons; Etude de la production de faisceaux riches en neutrons par fission induite par neutrons rapides

    Energy Technology Data Exchange (ETDEWEB)

    Lau, Ch

    2000-09-15

    This work is a contribution to the PARRNe project (production of radioactive neutron-rich isotopes). This project is based on the fission fragments coming from the fission of 238-uranium induced by fast neutrons. The fast neutron flux is produced by the collisions of deutons in a converter. Thick targets of uranium carbide and liquid uranium targets have been designed in order to allow a quick release of fission fragments. A device, able to trap on a cryogenic thimble rare gas released by the target, has allowed the production of radioactive nuclei whose half-life is about 1 second. This installation has been settled to different deuton accelerators in the framework of the European collaboration SPIRAL-2. A calibration experiment has proved the feasibility of fixing an ISOL-type isotope separator to a 15 MV tandem accelerator, this installation can provide 500 nA deutons beams whose energy is 26 MeV and be a valuable tool for studying fast-neutron induced fission. Zinc, krypton, rubidium, cadmium, iodine, xenon and cesium beams have been produced in this installation. The most intense beams reach 10000 nuclei by micro-coulomb for 26 MeV deutons. An extra gain of 2 magnitude orders can be obtained by using a more specific ion source and by increasing the thickness of the target. Another extra gain of 2 magnitude orders involves 100 MeV deutons.

  3. suPAR

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian

    2015-01-01

    The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events ...... comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events....

  4. Experiment of decontamination of radioactive liquid by a biological method; Experience de decontamination de liquides radioactifs far voie biologique

    Energy Technology Data Exchange (ETDEWEB)

    Wormser, G.

    1962-07-01

    The author reports experiments of treatment of radioactive liquid effluents by percolation on a bacterial bed like the one used for the treatment of sewer wastewaters. He also reports results obtained in other countries in terms of reduction of effluent radioactivity for various radioactive ions. The installation is described and results are presented in terms of variation of contamination of an effluent with respect to its recycling on a bacterial bed [French] Dans le monde entier, on se preoccupe des moyens de decontamination pour des liquides radioactifs. Les experiences de l'auteur ont confirme qu'un lit bacterien neuf peut donner de bons resultats: il est a noter que ce procede biologique se montre selectif a l'egard des divers ions radioactifs. (auteur)

  5. Par Pond water balance

    International Nuclear Information System (INIS)

    Hiergesell, R.A.; Dixon, K.L.

    1996-06-01

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  6. FooPar

    DEFF Research Database (Denmark)

    Hargreaves, F. P.; Merkle, D.

    2013-01-01

    We present FooPar, an extension for highly efficient Parallel Computing in the multi-paradigm programming language Scala. Scala offers concise and clean syntax and integrates functional programming features. Our framework FooPar combines these features with parallel computing techniques. Foo......, results based on a empirical analysis on two supercomputers are given. We achieve close-to-optimal performance wrt. theoretical peak performance. Based on this result we conclude that FooPar allows programmers to fully access Scalas design features without suffering from performance drops when compared...

  7. Some Questions on the Fixation of Radioisotopes in Connexion with the Problem of their Safe Burial; Quelques Aspects de la Fixation des Isotopes Radioactifs en Rapport avec le Probleme de leur Elimination dans le Sol; 041d 0414 ; Algunos Aspectos de la Fijacion de los Isotopos Radiactivos en Relacion con los Problemas de su Evacuacion sin Riesgos en el Suelo

    Energy Technology Data Exchange (ETDEWEB)

    Zimakov, P. V.; Kulichenko, V. V.

    1960-07-01

    The results given in this paper are based on the fact that the best way of burying fission products is to incorporate them in vitrified fused blocks containing these fission products. The physico-chemical bases of the transformation of liquid waste into solid blocks are shown. The thermogram of this process is presented and the analysis of its characteristics given. The conditions of fusion of the vitrified mass, in particular those contributing to the fixation of radioactive aerosols, are shown. Some results of studies on the chemical state of radioactive fission products in the solid mass in connexion with the leaching of their radioactivity are given. In conclusion, the results of calculations of the temperatures up to which the radioactive blocks may be heated according to their characteristics are presented. (author) [French] Le present memoire est base sur l'hypothese que le meilleur procede d'elimination des dechets radioactifs dans le sous:sol consiste a les enfouir sous forme de blocs coules dans lesquels ils seraient intimement meles a du verre. Les auteurs decrivent les phenomenes physico-chimiques qui permettent la transformation des dechets radioactifs liquides en blocs solides. Ils donnent le thermogramme de ce processus et examinent certaines de ses particularites. Ils exposent en outre les conditions de coulage de la masse de verre, notamment celles qui facilitent la formation d'aerosols radioactifs. Les auteurs donnent quelques resultats des etudes effectuees sur l'etat chimique des elements radioactifs au sein de la masse solide, dans la mesure ou ces resultats touchent aux problemes que pose la fuite de la radioactivite due au 'lessivage' du bloc par l'eau. En conclusion, les auteurs indiquent les resultats du calcul des temperatures maxima auxquelles on peut porter les blocs radioactifs compte tenu de leurs caracteristiques. (author) [Spanish] Los autores de la memoria parten del supuesto de que la mejor manera de evacuar en el suelo los

  8. The use of an experimental device for the determination of the concentration of artificial radioactive aerosols at high altitudes; Utilisation d'un missile experimental pour l'evaluation des concentrations en aerosols radioactifs artificiels en haute altitude

    Energy Technology Data Exchange (ETDEWEB)

    Boclet, D; Jehanno, C; Labeyrie, J [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Le Boiteux, H [Office National d' Etudes et de Recherches Aeronautique, 92 - Chatillon sous Bagneux (France)

    1960-07-01

    By means of measurements with a Geiger counter on january, the 27{sup th}, in 1959 at an altitude reaching 65 km approximately, and following comparison with similar measurements made by Gangnes, Jenkins and Van Allen in 1949 at the same geomagnetic latitude (41 deg. North), it is concluded that radioactive aerosols above Southern France tropopause had a concentration less than 100.10{sup -12} curies/m{sup 3} at that time. The missile used for this purpose and its performance are quickly described in this paper. (author) [French] Au moyen de mesures faites au compteur Geiger le 27 janvier 1959 jusqu'au environ de 65 km et apres comparaison avec des mesures analogues faites en 1949 par Gangnes, Jenkins et Van Allen a la meme altitude geomagnetique (41deg. N), on conclut que les aerosols radioactifs au-dessus de la tropopause de la France meridionale avaient a cette epoque une concentration inferieure a 100.10{sup -12} curies/m{sup 3}. Une rapide description du missile utilise et de ses performances complete cette communication. (auteur)

  9. Count rate balance method of measuring sediment transport of sand beds by radioactive tracers; Methode du bilan des taux de comptage d'indicateurs radioactifs pour la determination du debit de charriage des lits sableux

    Energy Technology Data Exchange (ETDEWEB)

    Sauzay, G [Commissariat a l' Energie Atomique, 91 - Saclay (France). Centre d' Etudes Nucleaires

    1967-11-01

    Radioactive tracers are applied to the direct measurement of the sediment transport rate of sand beds. The theoretical measurement formula is derived: the variation of the count rate balance is inverse of that of the transport thickness. Simultaneously the representativeness of the tracer is critically studied. The minimum quantity of tracer which has to be injected in order to obtain a correct statistical definition of count rate given by a low number of grains 'seen' by the detector is then studied. A field experiment was made and has let to study the technological conditions for applying this method: only the treatment of results is new, the experiment itself is carried out with conventional techniques applied with great care. (author) [French] Les indicateurs radioactifs sont appliques a la mesure directe du debit de charriage des lits sableux. On etablit la formule theorique de mesure: le bilan des taux de comptage varie en sens inverse de l'epaisseur de charriage. Parallelement on fait une etude critique de la representativite de l'indicateur, puis on determine la quantite minimale de traceur qu'il faut immerger pour que les taux de comptage fournis pour un faible nombre de grains 'vus' par le detecteur aient une definition statistique correcte. Une experience de terrain a permis d'etudier les conditions technologiques de cette methode: seul le depouillement des resultats est nouveau. L'experimentation in-situ se fait suivant les procedes classiques avec un tres grand soin. (auteur)

  10. Caesium absorption by barley - influence of its retention by the soil - competitive action of potassium; Absorption du cesium par l'orge - influence de sa retention dans le sol - action competitive du potassium

    Energy Technology Data Exchange (ETDEWEB)

    Ferron-Trosseau, F. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-06-01

    plants such as rice and cress growing on flooded soils. Radio-active caesium however incorporated without carrier into a soil of medium-exchange capacity (of about 150 milli-equivalents per kilo) presents relatively little danger because of the close interdependence of the radioactive caesium take-up from the soil by the plants and its retention by the soil. Our research has made it possible furthermore to examine the value of various partial decontamination methods for soils proposed by certain atomic scientists: just as isotopic dilution appears totally inadequate for this purpose, so does it seems that the addition of potassium salts in amounts greater than nutritive optimum is incapable of reducing the absorption of radioactive caesium by the plant. (author) [French] Nous avons recherche, dans divers milieux de culture, comment l'absorption du cesium par l'orge varie avec sa concentration et comment cette absorption peut etre concurrencee par un cation alcalin voisin,le potassium. En outre, nous avons considere la distribution du cesium dans le sol - notamment du cesium radioactif - entre terre et solution, en fonction du taux de cesium. De notre etude ressort une nette opposition entre le comportement de l'orge vis a vis du cesium d'une solution nutritive et vis a vis du cesium d'un sol: sur solution nutritive, la fraction du cesium (radioactif et stable) absorbee par l'orge demeure pratiquement constante en presence de proportions croissantes (relativement petites) de cesium stable; sur sol, la fraction du cesium radioactif absorbee par l'orge a augmente en meme temps que le taux (relativement petit) de cesium stable du sol, en relation avec une selectivite rapidement decroissante du sol pour Cs. La difference entre ces resultats est donc expliquee par une tres forte selectivite du sol illitique experimente pour Cs{sup +} tant que la proportion da cesium reste tres petite, de l'ordre de celle de la plupart des sols naturels

  11. Caesium absorption by barley - influence of its retention by the soil - competitive action of potassium; Absorption du cesium par l'orge - influence de sa retention dans le sol - action competitive du potassium

    Energy Technology Data Exchange (ETDEWEB)

    Ferron-Trosseau, F [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-06-01

    as rice and cress growing on flooded soils. Radio-active caesium however incorporated without carrier into a soil of medium-exchange capacity (of about 150 milli-equivalents per kilo) presents relatively little danger because of the close interdependence of the radioactive caesium take-up from the soil by the plants and its retention by the soil. Our research has made it possible furthermore to examine the value of various partial decontamination methods for soils proposed by certain atomic scientists: just as isotopic dilution appears totally inadequate for this purpose, so does it seems that the addition of potassium salts in amounts greater than nutritive optimum is incapable of reducing the absorption of radioactive caesium by the plant. (author) [French] Nous avons recherche, dans divers milieux de culture, comment l'absorption du cesium par l'orge varie avec sa concentration et comment cette absorption peut etre concurrencee par un cation alcalin voisin,le potassium. En outre, nous avons considere la distribution du cesium dans le sol - notamment du cesium radioactif - entre terre et solution, en fonction du taux de cesium. De notre etude ressort une nette opposition entre le comportement de l'orge vis a vis du cesium d'une solution nutritive et vis a vis du cesium d'un sol: sur solution nutritive, la fraction du cesium (radioactif et stable) absorbee par l'orge demeure pratiquement constante en presence de proportions croissantes (relativement petites) de cesium stable; sur sol, la fraction du cesium radioactif absorbee par l'orge a augmente en meme temps que le taux (relativement petit) de cesium stable du sol, en relation avec une selectivite rapidement decroissante du sol pour Cs. La difference entre ces resultats est donc expliquee par une tres forte selectivite du sol illitique experimente pour Cs{sup +} tant que la proportion da cesium reste tres petite, de l'ordre de celle de la plupart des sols naturels. Par ailleurs, l'ion K{sup +} n'a concurrence l

  12. The use radioactive tracers in the study of solid transport in water streams; Emploi de traceurs radioactifs pour l'etude du transport solide dans les cours d'eau

    Energy Technology Data Exchange (ETDEWEB)

    Courtois, G [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Jaffry, P; Heuzel, M [Laboratoire National d' Hydraulique de Chatou, 78 (France)

    1960-07-01

    The Laboratoire National d'Hydraulique which has been studying, during the last few years in conjunction with the Centre d'Etudes Nucleaires at Saclay, the development of apparatus and of methods of investigation of sediment transport by radioactive tracer techniques, is at the moment trying to perfect a genuinely quantitative method of investigation. Two experiments have recently been carried out in rivers, the first designed to investigate the transport of pebbles in the river Rhone, the other to investigate the movement of sands in the Niger. This second experiment has been supported by parallel experiments carried out on a reduced scale model of the Niger built at the laboratories of Chatou: in this experiment are used the radiation from {sup 56}Mn and {sup 24}Na obtained by direct activation of the crushed apricot store which represents, in the scale model, the natural sediment on the bed of the Niger. The combined efforts of the laboratories of Chatou and of the Centre d'Etudes Nucleaires at Saclay are at the moment directed to the application of radioactive tracers to studies on the scale models with the double aim: a) of having a single investigational method for the actual experiment and for the model making it possible to control the accuracy of the model in the preliminary stage of calibrating this model; b) of making the most of the possibilities of observation and of direct measurement offered by the scale models for studying the possibility of improving the tracer method, in particular with respect to the collecting of quantitative data. (author) [French] La Laboratoire National d'Hydraulique qui, depuis quelques annees a developpe, en collaboration avec le Centre d'Etudes Nucleaires de Saclay, les appareillages et les techniques d'etudes des mouvements de sediments par la methode des traceurs radioactifs, s'efforce actuellement de mettre au point un moyen d'investigation veritablement quantitatif. Deux experiences ont ete effectuees recemment en

  13. Decontamination of lead by fusion (1962); Decontamination du plomb par fusion (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Boutot, P; Giachetto, L; Capitaine, A [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1962-07-01

    Various attempts to decontaminate using mechanical and chemical methods having given questionable results, a fusion method has been developed. The apparatus consists of a propane-heated oven fitted with a steel crucible of 1 400 kg capacity, with two ventilation systems, and with a vacuum gauge for preventing the diffusion of toxic gases. There are three operational controls : 1. On the samples taken before during and after the operation, 2. On the plugs taken from the ingots, 3. On the ingot itself. The continuous sanitary control is done by a radioactive aerosol recorder and by periodic sampling. This decontamination process will be improved, especially as far as the productivity and the safety precautions are concerned. (authors) [French] Divers essais de decontamination par voies mecaniques et chimiques ayant donne des resultats discutables, un procede par fusion a ete mis au point. L'appareil se compose d'un four, chauffe au propane, muni d'un creuset en acier d'une capacite de 1 400 kg, de deux systemes de ventilation et d'un deprimometre afin d'eviter la diffusion de vapeurs nocives. Trois controles d'activite sont effectues: 1. sur des echantillons preleves avant, pendant et apres l'operation, 2. sur des carottages realises sur les lingots, 3. sur le lingot lui-meme. Le controle sanitaire permanent est assure par un enregistreur d'aerosols radioactifs et par des prelevements periodiques. Ce procede de decontamination doit encore etre ameliore, principalement en ce qui concerne la productivite et la securite. (auteurs)

  14. L'analyse par activation de neutrons de réacteur

    Science.gov (United States)

    Meyer, G.

    2003-02-01

    Quand les neutrons traversent la matière, certains sont transmis sans interaction, les autres interagissent avec le milieu traversé par diffusion et par absorption. Ce phénomène d'absorption est utilisé pour se protéger des neutrons, mais aussi pour les détecter; il peut également être utilisé pour identifier les noyaux “absorbants" et ainsi analyser le milieu traversé. En effet par différentes réactions nucléaires (n,γ), (n,p), (n,α), (n,fission), on obtient des noyaux résiduels qui sont souvent radioactifs; on dit que l'échantillon est “activé". Si l'on connaît le rendement d'activation et donc le pourcentage de noyaux ainsi “transmutés", les mesures de radioactivité induite vont permettre de déterminer la composition de l'échantillon irradié. Cette méthode dite d'analyse par activation neutronique est pratiquée depuis la découverte du neutron. Elle a permis grâce à sa sélectivité et à sa sensibilité d'avoir accès au domaine des traces et des ultra-traces dans des champs d'application très divers comme la métallurgie, l'archéologie, la biologie, la géochimie etc...

  15. Technical and Economic Problems Associated with the Development of Methods of Processing and Using Radioactive Waste; Problemes techniques et economiques lies au developpement des methodes de traitement et d'utilisation des dechets radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Thiriet, L; Sauteron, J; Oger, C [Commissariat a l' Energie Atomique, Fontenay-Aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    The paper briefly reviews the various techniques used in processing the radioactive wastes which unavoidably result from the generation of electric power from nuclear sources. The paper goes on to define the relative importance, in nuclear fuel cycles, of the problem raised by these wastes. Emphasis is placed on the economic influence of management policies on the cost of power generation, and hence on the relative position of nuclear energy. A substantial percentage of these wastes can be economically utilized. Attention is drawn to the major technical and economic features of the industry which will come into being as a result of this utilization. The major uses anticipated are discussed: radiation sources, heat sources, auxiliary power generation. The paper concludes that satisfactory solutions have already been found to these problems, and describes possible improvements. (author) [French] La communication rappelle d'abord succinctement les differentes techniques de traitement des dechets radioactifs resultant necessairement de la production d'electricite d'origine nucleaire. On situe ensuite l'importance du probleme pose par ces residus dans le cycle du combustible nucleaire. On fait ressortir l'influence economique du choix des methodes de gestion sur le cout de production de l'energie, et par consequent sur la place devolue a l'energie nucleaire. Une part importante de ces dechets peut faire l'objet d'une utilisation rentable de l'industrie qui naitra de cette utilisation. Les principales applications envisagees sont evoquees: sources d'irradiation, sources chauffantes, generateurs auxiliaires d'energie. On conclut que d'ores et deja des solutions satisfaisantes ont ete apportees a ces problemes, et l'on decrit les perspectives d'amelioration concevables. (auteur)

  16. It's quicker "Par Avignon"!

    CERN Multimedia

    2005-01-01

    For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!

  17. Treatment and final conditioning of solid radioactive wastes; Traitement et conditionnement definitif des dechets radioactifs solides

    Energy Technology Data Exchange (ETDEWEB)

    Cerre, J [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    The storage of solid radioactive wastes on a site is so cumbersome and dangerous that we have developed a method of treatment and conditioning by means of which the volume of waste is considerably reduced and very long-lasting shielding can be provided. This paper describes the techniques adopted at Saclay, where the wastes are sheared, compressed and enveloped in concrete of variable thickness. The main part of the report is devoted to a description of the corresponding remote handling installation. (author) [French] L'encombrement et le danger que presentent sur un site le stockage de dechets radioactifs solides nous ont amenes a etudier un mode de traitement et de conditionnement permettant une sensible reduction du volume des dechets et une protection de tres longue duree. La presente communication expose les techniques adoptees a Saclay ou les dechets sont cisailles, comprimes et enrobes dans du beton d'epaisseur variable. La description de l'installation telecommandee correspondante fait l'objet principal de cette communication. (auteur)

  18. Determination of radioactive risks connected with the working of a nuclear plant; Evaluation des risques radioactifs lies au fonctionnement d'une installation nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Lavie, J M; Doury, A [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    Numerous problems which are posed by the evaluation of the radioactive risks linked to the working of a nuclear plant are new problems which have not yet been satisfactorily solved. In these conditions this study must be considered only as a preliminary approach whose essential aims are the following: - development and synthesis of the existing data; - rapid determination of conservative and usable orders of greatness for the security factors, both for normal working and in the case of an accident. The most probable typical accidents are reviewed together with the nature of the resulting risks and the principal factors on which these risks depend. Among these factors, one of the most important is atmospheric diffusion which is studied in some detail using the analytic model due to Sutton. A logical graphical presentation increasing the flexibility in the use of the results and presents the responsible authorities with a flexible, practical and rapid means of evaluating the risks involved starting from a sufficiently general system of initial and simultaneously valid conditions (types of accident, atmospheric conditions). (author) [French] De nombreux problemes souleves par l'evaluation des risques radioactifs lies au fonctionnement d'une installation nucleaire sont des problemes nouveaux qui n'ont pas encore recu de solution satisfaisante. Dans ces conditions cette etude ne doit etre consideree que comme une premiere approche dont les objectifs essentiels sont les suivants: - mise au point et synthese de donnees existantes; - determination rapide d'ordres de grandeur conservatifs et utilisables de valeurs de securite, tant en fonctionnement normal qu'en cas d'accident. Les accidents types les plus probables sont passes en revue ainsi que la nature des risques qui en decoulent et les principaux facteurs dont dependent ces risques. Parmi ces facteurs, l'un des plus importants est la diffusion atmospherique qui fait l'objet d'une etude particuliere a l'aide du modele

  19. Treatment and Processing of Radioactive Wastes; Traitement des Dechets Radioactifs; 041e 0411 0420 0414 ; Tratamiento de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Rodger, Walton A. [Chemical Engineering Division, Argonne National Laboratory, Lemont, IL (United States)

    1960-07-01

    'auteur decrit des installations type. On a envisage la possibilite d'incinerer les dechets combustibles et l'auteur decrit cette methode en precisant les modalites d'application. La mise en paquets peut souvent completer utilement la collecte des dechets. L'auteur etudie un certain nombre de procedes pour les dechets liquides. Il decrit egalement des systemes type en expliquant leur fonctionnement. Dechets de haute radioactivite - Les gaz sont parfois decharges directement dans des cheminees, mais le plus souvent on leur fait subir certains traitements. On peut, soit les epurer par des processus chimiques, retirer l'iode par reaction avec l'argent, extraire les gaz rares ou encore recourir au filtrage. Les solides fortement contamines peuvent necessiter une decontamination sur place avant la collecte. Les dechets liquides fortement radioactifs constituent a l'heure actuelle la plus forte proportion de dechets a eliminer par l'industrie. On a cherche a resoudre le probleme en reduisant le volume des dechets produits en changeant le processus ; on peut aussi concentrer les dechets produits ou bien les reduire sous forme solide - plusieurs methodes sont employees a cet effet, notamment la concentration, l'utilisation de ciment de Portland, l'adsorption sur argile ou autre materiau naturel et la calcination. L'auteur examine les problemes techniques et economiques qui se posent a propos de l'entreposage provisoire. Il peut etre necessaire de ne traiter les dechets qu'en un petit nombre d'endroits soigneusement determines. L'auteur a calcule approximativement les quantites et le materiel necessaire au deplacement. Il etudie egalement les risques afferents et les incidences financieres. (author) [Spanish] El autor examina algunos de los metodos que se han propuesto para tratar los desechos radiactivos de baja y elevada actividad. Desechos de baja actividad - Una vez diluidos, los gases se descargan en la atmosfera mediante chimeneas o se hacen pasar por filtros de elevado poder de

  20. La pelade par plaques

    Science.gov (United States)

    Spano, Frank; Donovan, Jeff C.

    2015-01-01

    Résumé Objectif Présenter aux médecins de famille des renseignements de base pour faire comprendre l’épidémiologie, la pathogenèse, l’histologie et l’approche clinique au diagnostic de la pelade par plaques. Sources des données Une recension a été effectuée dans PubMed pour trouver des articles pertinents concernant la pathogenèse, le diagnostic et le pronostic de la pelade par plaques. Message principal La pelade par plaques est une forme de perte pileuse auto-immune dont la prévalence durant une vie est d’environ 2 %. Des antécédents personnels ou familiaux de troubles auto-immuns concomitants, comme le vitiligo ou une maladie de la thyroïde, peuvent être observés dans un petit sous-groupe de patients. Le diagnostic peut souvent être posé de manière clinique en se fondant sur la perte de cheveux non cicatricielle et circulaire caractéristique, accompagnée de cheveux en « point d’exclamation » en périphérie chez ceux dont le problème en est aux premiers stades. Le diagnostic des cas plus complexes ou des présentations inhabituelles peut être facilité par une biopsie et un examen histologique. Le pronostic varie largement et de mauvais résultats sont associés à une apparition à un âge précoce, une perte importante, la variante ophiasis, des changements aux ongles, des antécédents familiaux ou des troubles auto-immuns concomitants. Conclusion La pelade par plaques est une forme auto-immune de perte de cheveux périodiquement observée en soins primaires. Les médecins de famille sont bien placés pour identifier la pelade par plaques, déterminer la gravité de la maladie et poser le diagnostic différentiel approprié. De plus, ils sont en mesure de renseigner leurs patients à propos de l’évolution clinique de la maladie ainsi que du pronostic général selon le sous-type de patients.

  1. Disposal of Radioactive Wastes in Natural Salt; Elimination des Dechets Radioactifs dans le Sel Naturel; 0423 0414 ; Evacuacion de Desechos Radiactivos en Formaciones Salinas Naturales

    Energy Technology Data Exchange (ETDEWEB)

    Parker, F. L.; Boegly, W. J.; Bradshaw, R. L.; Empson, F. M.; Hemphill, L.; Struxness, E. G.; Tamura, T. [Health Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    1960-07-01

    diverses periodes geologiques ; 2. L'impermeabilite du sel a l'ecoulement d'eau; 3. La vaste repartition geographique du sel; 4. Les enormes quantites de sel existantes ; 5. La solidite structurale du sel; 6. La conductivite thermique relativement elevee du sel par rapport a d'autres formations geologiques generales; 7. La recuperation eventuelle de precieux produits de fission dans les dechets injectes dans le sel; 8. La facilite relative d'obtenir des excavations dans le sel par voie d'extraction, ainsi que la facilite encore plus grande et le cout reduit de la preparation dans le sol de cavites par voie de solution; 9. La faible seismicite constatee dans les zones des principaux gisements de sel. Les dechets radioactifs liquides peuvent etre emmagasines dans les cavites des formations de sel naturel, a condition que les proprietes structurales/du sel ne soient pas defavorablement influencees par les interactions chimiques, la pression, la temperature et les rayonnements. Il ressort d'etudes analytiques qu'on peut emmagasiner 3.200 litres (800 gallons) par tonne de dechets d'uranium irradie a 10.000 MWj/t, vieux de deux ans, dans une sphere de 3 metres (dix pieds) de diametre sans depasser une temperature de 93 Degree-Sign C (200 Degree-Sign F). Des essais de laboratoire montrent que les proprietes structurales et la conductivite thermique du sel gemme ne sont pas sensiblement transformees par des doses de rayonnements intenses, bien que les temperatures elevees augmentent le taux de fluage des echantillons irradies et non irradies. Les interactions chimiques de dechets liquides avec du sel donnent naissance a du chlore et a des composes gazeux du chlore, mais les volumes n'en sont pas excessifs. Les migrations des nuclides a travers le sel ainsi que la deformation de la cavite ne peuvent etre etudiees que sur place dans le sel vierge. Des maquettes a l'echelle de 1/5 ont ete essayees a Hutchinson (Kansas) dans un gisement de sel; des essais d'une certaine importance

  2. Storing and evacuation of solid radioactive waste (1960); Stockage et evacuation des dechets radioactifs solides (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Pomarola, J [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    The object of this paper is to present the plans under consideration for the final destination of solid radioactive wastes. 1) It is first of all necessary to provide in each centre an organised temporary storage dump. Several types of temporary dumps are suitable and can coexist in the same area; on the ground, in buildings; in basements. 2) Definitive storage. To accomplish a definitive storage arrangement it is necessary, as a function of the activity and the conditioning of the wastes, to define: - the site and the means of transport considered both inside and outside nuclear centres. The solution adopted depends on the above imperatives, and plans for definitive storage on the ground, under ground and in the sea are examined successively. Economic considerations play a large part in the decision reached. (author) [French] La presente communication a pour objet les solutions envisagees pour une destination finale des dechets radioactifs solide. 1) Il est tout d'abord necessaire de prevoir, dans chaque centre, un stockage provisoire organise. Plusieurs types de stockage previsoire peuvent convenir et coexister sur une meme aire; stockage sur le sol; stockage en batiment; stockage en sous-sol. 2) Stockage definitif. La realisation d'un stockage definitif rend necessaire, en fonction de l'activite et du conditionnement des dechets, la definition: - du site et des modes de transports envisages a l'interieur et a l'exterieur des Centres Nucleaires. Le choix des solutions decoule des imperatifs ci-dessus et on examine successivement le stockage definitif, - sur le sol; dans le sous-sol; en mer. Les considerations d'ordre economique constituent un facteur important dans le choix de la solution. (auteur)

  3. Waste Disposal Research and Development in the United States of America; L'Elimination des Dechets Radioactifs aux Etats-Unis d'Amerique: Travaux de Recherche et Progres Accomplis; 0418 0417 0423 0427 0414 ; Investigaciones y Trabajos Realizados en los Estados Unidos en Materia de Evacuacion de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Struxness, E. G.; Cowser, K. E.; De Laguna, W.; Jacobs, D. G.; Morton, R. J.; Tamura, T. [Health Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    1960-07-01

    A review of the waste-disposal research and development carried out in the United States of America is given. The major research effort concerns the conversion of high-level liquid wastes into solids. At Hanford and Oak Ridge low-level wastes are disposed to the ground in pits, cribs and lagoons. Geochemical studies related to waste disposal are conducted at Hanford, Oak Ridge and the University of North Carolina. Experiments with soil columns ate described ; these are more effective for the decontamination of waste streams than either cribs or pits. The most suitable exchange materials for the soil columns are found to be vermiculite supported by rock phosphate and the latter supported by graded gravel. The progress of research work on the possibility of injecting radioactive liquid wastes into porous formations through deep wells and disposing of radioactive wastes in impermeable formations by hydraulic fracturing is outlined. (author) [French] L'auteur passe en revue les recherches effectuees aux Etats-Unis en matiere d'elimination des dechets radioactifs et les progres accomplis dans ce domaine. En matiere de recherche, on s'attache principalement a la conversion en solides des dechets liquides de haute activite. A Hanford et a Oak Ridge, les dechets de faible activite sont elimines par decharge terrestre dans des coffres, puits et depots lagunaires. Des etudes de geochimie se rapportant a l'elimination des dechets sont en cours a Hanford, a Oak Ridge et l'Universite de Caroline du Nord. Le memoire decrit les experiences faites avec des colonnes ; pour decontaminer les dechets liquides, ces dernieres sont plus efficaces que les coffres ou les puits. Les substances echangeuses d'ions les plus appropriees pour les colonnes sont vermiculite-phosphate naturel-gravier trie. L'auteur expose les progres dea travaux de recherche portant sur la possibilite d'injecter des dechets radioactifs liquides dans des formations poreuses, par decharge dans des puits profonds, et

  4. suPAR

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Giamarellos-Bourboulis, Evangelos J

    2015-01-01

    Investigation of biomarkers that can promptly predict unfavourable outcome of critically illness is an emerging necessity taking into consideration the need for early intervention, the shortage of available beds in intensive care units and the considerable cost of hospitalisation. The most...... promising biomarker is soluble urokinase-type plasminogen activator receptor (suPAR). Three studies in large populations of critically ill patients and patients admitted to the emergency department have shown that concentrations >12ng/mL can safely predict unfavourable outcome. This review presents...

  5. The use of polarized deuterons beams and the determination of the optical model parameters; Utilisation de faisceaux de deutons polarises et determination des parametres du modele optique

    Energy Technology Data Exchange (ETDEWEB)

    Raynal, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-06-15

    A general description of beams of polarized particles in nuclear reactions is studied; the various choices necessary to define the polarization parameters are discussed with regard to their consequences. The frequent occurrence of symmetry plane yields a set of relations among these parameters. The range of these parameters is studied in particular for a beam of particles of spin 1 and with a symmetry plane. Nuclear reactions involving two bodies are described in terms of the helicity formalism. With the use of the adopted set of polarization parameters, the polarization of the final state is studied for a given polarization in the initial state. An optical model for deuterons may consist of a scalar term, an L.S potential and tensor potentials built with the distance between the deuteron and the nucleus, its angular momentum or its relative momentum. Calculations have been made with the first two tensor potentials. Many authors have calculated a potential for deuterons starting from the nucleon-nucleus potential. These calculations are redone taking into account both the S and D waves of the deuteron. The various terms of the potential have been calculated with a set of different intrinsic wave functions. The use of a potential not limited to scalar form yields good fits for cross-sections with nuclear radii which are greater than those necessary with a purely central potential. The experimental results obtained at Saclay for the polarization of deuterons elastically scattered by Ca are not compatible with the existence of an important tensor potential; they can be accounted for by an L.S coupling potential independent of the central potential but with very small radii. (author) [French] La description de faisceaux do particules polarisees dans les reactions nucleaires est etudiee de facon generale; les choix necessaires pour definir les parametres de polarisation sont discutes en fonction de leurs consequences. L'existence tres frequente d'un plan de symetrie

  6. Parálisis cerebral :

    OpenAIRE

    Cabrero Izquierdo, María del Carmen

    2012-01-01

    Se aborda el tema de la parálisis cerebral definiendo qué es, clasificando los tipos de parálisis dependiendo de la afectación y las características principales. Se explican algunos de sus tratamientos, se dan sistemas alternativos y/o aumentativos de comunicación para un alumno con PC (parálisis cerebral).

  7. The pretreatment of uranium ores by physical processing; Les problemes de la preconcentration des minerais d'uranium par voie physique

    Energy Technology Data Exchange (ETDEWEB)

    Vuchot, L; Ginocchio, A; Hubert, G; Roques, E; Sandier, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    After giving an outline of the classical means of physical processing - granulometry, gravimetry, flotation, magnetism, electrostatics, the authors study the methods peculiar to radioactive ores: pretreatment in batches (counting cylinders) or stone by stone (electronic sorting belt). The three factors to be considered in any treatment operation are studied (cost of the operation, metal recovery, ratio of concentration), as well as their bearing on the cost and the productivity of the following operations. Making use of radioactivity in order to find out instantaneously the approximate grade of the obtained product makes it possible to reduce costs and improve results by setting up total automation. (author) [French] Apres un apercu des procedes classiques de concentration physique des minerais - granulometrie, gravimetrie, flottation, magnetisme et electrostatique, les auteurs s'attachent aux methodes propres aux minerais radioactifs: preconcentration par lots (cylindre de comptage) ou caillou par caillou (bande de triage electronique). Les trois facteurs a considerer lors de toute operation de traitement sont etudies (prix de revient de l'operation, rendement metal et rendement poids), ainsi que leurs repercussions sur les prix de revient et rendements des traitements ulterieurs. L'utilisation de la radioactivite pour determiner instantanement la teneur approximative des produits obtenus permet d'envisager de reduire les prix de revient et d'ameliorer les resultats par une automatisation totale. (auteur)

  8. The pretreatment of uranium ores by physical processing; Les problemes de la preconcentration des minerais d'uranium par voie physique

    Energy Technology Data Exchange (ETDEWEB)

    Vuchot, L.; Ginocchio, A.; Hubert, G.; Roques, E.; Sandier, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    After giving an outline of the classical means of physical processing - granulometry, gravimetry, flotation, magnetism, electrostatics, the authors study the methods peculiar to radioactive ores: pretreatment in batches (counting cylinders) or stone by stone (electronic sorting belt). The three factors to be considered in any treatment operation are studied (cost of the operation, metal recovery, ratio of concentration), as well as their bearing on the cost and the productivity of the following operations. Making use of radioactivity in order to find out instantaneously the approximate grade of the obtained product makes it possible to reduce costs and improve results by setting up total automation. (author) [French] Apres un apercu des procedes classiques de concentration physique des minerais - granulometrie, gravimetrie, flottation, magnetisme et electrostatique, les auteurs s'attachent aux methodes propres aux minerais radioactifs: preconcentration par lots (cylindre de comptage) ou caillou par caillou (bande de triage electronique). Les trois facteurs a considerer lors de toute operation de traitement sont etudies (prix de revient de l'operation, rendement metal et rendement poids), ainsi que leurs repercussions sur les prix de revient et rendements des traitements ulterieurs. L'utilisation de la radioactivite pour determiner instantanement la teneur approximative des produits obtenus permet d'envisager de reduire les prix de revient et d'ameliorer les resultats par une automatisation totale. (auteur)

  9. New instruments and methods for measuring the concentration of radioactive products in the atmosphere; Appareils recents et methodes nouvelles pour la mesure de la concentration des produits radioactifs dans l'atmosphere

    Energy Technology Data Exchange (ETDEWEB)

    Jehanno, C; Blanc, A; Lallemant, C; Roux, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1959-07-01

    ) [French] Differents enregistreurs pour aerosols radioactifs ont ete realises pour mesurer la pollution de l'atmosphere des laboratoires ou l'atmosphere exterieure. EAR 600. - Permet de mesurer en continu instantanement et 3 a 10 heures apres le prelevement des concentrations d'aerosols emetteurs {alpha} ou {beta} allant de quelques 10{sup -11} a quelques 10{sup -8} curies par metre cube d'air. EAR 800. - Permet de mesurer en continu des concentrations d'aerosols emetteurs {alpha} allant de 10{sup -11} a 10{sup -5} curie par metre cube d'air, et des concentrations d'aerosols emetteurs {beta} allant de 10{sup -11} a 10{sup -1} curie par metre cube d'air. EAR PLUTONIUM. - Permet de detecter en quelques minutes 1000 DMP (2.10{sup -9} curie par metre cube) et en 8 heures 1 DMP (2.10{sup -12} curie par metre cube). Deux methodes sont utilisees pour separer l'activite due au plutonium de celle due aux derives du radon et du thoron: a) par discrimination d'amplitude, b) par les coincidences (a,b) RaC' et ThC-ThC'. SP 4. - Monte sur jeep, cet ensemble permet la mesure de l'irradiation produite au sol par le panache des piles. La sensibilite est de 5{mu}R/h. A.D.I.R. - Cet appareil autonome et portatif est destine a la mesure instantanee des teneurs en radon de l'atmosphere des mines. Il permet de mesurer des teneurs de l'air variant entre 0,4 et 400.10{sup -10} curie par litre d'air (0,4 et 400 DPM). La mesure des retombees radioactives est faite apres collection de cette activite par un pluviometre special comportant une surface adhesive et une cartouche de resines echangeuses d'ions. La radioactivite des retombees varie entre quelques 10{sup -9} et quelques 10{sup -7} curie par metre carre et par mois. La mesure des concentrations de l'atmosphere en produits de fission est faite apres collection sur papier filtre. Les concentrations mesurees dans l'air au niveau du sol varient entre 10{sup -13} et 10{sup -12} curie par metre cube. (auteur)

  10. Treatment with charged particles beams: hadron therapy part 1: physical basis and clinical experience of treatment with protons; Le traitement par faisceaux de particules: hadrontherapie 1: bases physiques et experience clinique de la protontherapie

    Energy Technology Data Exchange (ETDEWEB)

    Noel, G.; Feuvret, L.; Ferrand, R.; Mazeron, J.J. [Centre de Protontherapie d' Orsay, 91 (France); Mazeron, J.J. [Centre des Tumeurs, Groupe Hospitalier Universitaire Pitie-Salpetriere, 75 - Paris (France)

    2003-10-01

    Protons have physical characteristics, which differ from those of photons used in conventional radiotherapy. Better shielding of critical organs is obtained by using their particular ballistic (Bragg peak and lateral narrow penumbra). Some indications as ocular melanoma, chordoma and chondrosarcoma of the base of skull are now strongly accepted by the radiation oncologist community. Others are still in evaluation: meningioma, locally advanced nasopharynx tumor and paediatric tumors. The aim of this review is to present the clinical results of a technic which seems 'confidential' because of the rarity and the cost of equipments. (authors)

  11. Modeling of polarization phenomena due to RF sheaths and electron beams in magnetized plasma; Modelisation de phenomenes de polarisation par des gaines rf et des faisceaux electroniques dans un plasma magnetise

    Energy Technology Data Exchange (ETDEWEB)

    Faudot, E

    2005-07-01

    This work investigates the problematic of hot spots induced by accelerated particle fluxes in tokamaks. It is shown that the polarization due to sheaths in the edge plasma in which an electron beam at a high level of energy is injected, can reach several hundreds volts and thus extend the deposition area. The notion of obstructed sheath is introduced and explains the acceleration of energy deposition by the decreasing of the sheath potential. Then, a 2-dimensional fluid modeling of flux tubes in front of ICRF antennae allows us to calculate the rectified potentials taking into account RF polarization currents transverse to magnetic field lines. The 2-dimensional fluid code designed validates the analytical results which show that the DC rectified potential is 50% greater with polarization currents than without. Finally, the simultaneous application of an electron beam and a RF potential reveals that the potentials due to each phenomenon are additives when RF potential is much greater than beam polarization. The density depletion of polarized flux tubes in 2-dimensional PIC (particles in cells) simulations is characterized but not yet explained. (author)

  12. Applicability of ICRP principles for safety analysis of radioactive waste geological storage; Etude de l'applicabilite des principes de la CIPR a l'analyse de surete du stockage geologique des dechets radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Lombard, J; Hubert, P; Pages, P

    1987-07-01

    Since the beginning of the eighties, the international organisations have established new recommendations for radioactive waste management. These recommendations are based on two principles. First is concerned with limitation of risks. It should be shown that the risk is smaller than the limit of acceptance. Practically only on risk criterion is foreseen. The principle demands, if a storage causes an event of individual risk (defined as a product of probability of occurrence and the probability of its causing severe health effects) is higher than 10 {sup -5} per year, this storage is not acceptable. The second principle deals with optimisation, demands that the level of protection related to the storage should be determined by a comparative process choosing the best compromise between the price of protection and the residual risk. These recommendations, especially the second one, differ from the safety analysis principles adopted presently in France and other countries. This study analyzes the advantages and potential inconveniences related to the introduction of the second principle. (author) [French] Depuis le debut des annees quatre vingt, de nouvelles recommandations ont ete formulees par les organismes internationaux (AIEA, OCDE, OIPR) en matiere de gestion des dechets radioactifs. Ces recommandations s'articulent autour de deux principes. Le premier, est celui de limitation des risques. II s'agit de demontrer que le risque est inferieur a un seuil d'acceptabilite. En pratique, un seul critere de risque est envisage. Ainsi le principe stipule, que si un stockage est a I'origine d'evenements conduisant a un risque individuel (defini comme le produit de a probabilite d'occurrence de l'evenement par Ia probabilite que cet evenement cause un effet sanitaire grave) total annuel superieur a 10{sup -5}/an, alors le risque lie a ce stockage est juge inacceptable. Le second, dit d'optimisation, stipule que le niveau de protection associe a un stockage (donc les

  13. Disposal of Waste into the Atmosphere; Elimination des Dechets Radioactifs dans l'Atmosphere; 0423 0414 0410 ; Evacuacion de Desechos Radiactivos en la Atmosfera

    Energy Technology Data Exchange (ETDEWEB)

    Schulte, H. F. [Health Division, Los Alamos Scientific Laboratory, University of California, Los Alamos, NM (United States)

    1960-07-01

    The atmosphere can be compared to the hydrosphere and the lithosphere as a recipient of wastes, but the presence of airborne wastes is of more immediate concern to human life. There are two very distinct problems presented by atmospheric pollution, (1) that in the immediate vicinity of a plant and (2) the world-wide problem from long-term, widespread air pollution. Short- range problems have existed for many years as a result of non-radioactive wastes such as coal-smoke, sulphur dioxide and hydrogen fluoride. However, only in recent years has this problem received intense scientific study. Meteorological conditions play an important role in this problem. In some cases emission rates have been controlled in keeping with meteorological predictions. However, the basic solution is still that of reducing emission rates to the lowest possible values. (author) [French] L'atmosphere peut etre comparee a l'hydrosphere et a la lithosphere en tant que receptacle eventuel de dechets, mais la presence de dechets en suspension dans l'air est plus preoccupante pour la vie humaine. La pollution atmospherique pose deux problemes nettement distincts: 1) un probleme de portee limitee concernant le voisinage immediat d'une usine, et 2) un probleme de portee mondiale, savoir la pollution largement repandue, a long terme, de l'atmosphere. Des problemes de portee limitee se sont poses depuis de nombreuses annees ; ils sont lies a la presence dans l'atmosphere de dechets non radioactifs, tels que les fumees produites par le charbon, l'anhydride sulfurique et l'anhydride fluorhydrique. Cependant, ce n'est que recemment que ce probleme a ete soumis a une etude scientifique poussee. Les conditions meteorologiques jouent la un role important. Dans certains cas, les intensites d'emission ont ete controlees en tablant sur les previsions meteorologiques. Toutefois, la solution fondamentale est encore de reduire l'intensite d'emission a la plus faible valeur possible. (author) [Spanish] Si bien

  14. Disposal of the radioactive effluents at the 'Commissariat a l'Energie Atomique'. Treatment leading to evacuation into a river; Probleme du rejet des residus radioactifs liquides au CEA. Traitements aboutissant a des rejets en riviere

    Energy Technology Data Exchange (ETDEWEB)

    Duhamel,; Menoux,; Candillon, [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    loaded water, 10) Impot elements other than Sr{sup 90} are also studied. (author) [French] Le probleme du traitement des residus radioactifs liquides au CEA est envisage sous l'angle du rejet ultime en riviere dans des conditions optima permettant de satisfaire aux Normes de la protection. 2) A Saclay, ou l'on ne dispose que d'un etang ou l'eau ne se renouvelle pas, les liquides epures sont envoyes par camion citerne a Fontenay-aux-Roses, ou ils sont deverses provisoirement - dans les egouts - en attendant qu'un point de rejet en Seine ait ete determine. 3) Au Bouchet, les eaux residuaires de l'Usine de traitement de minerais d'urano-thorianite devront etre traitees en deux temps de facon a separer le radium dans une premiere phase, ce qui facilitera l'epuration au cours de la deuxieme phase. 4) En vue des futurs rejets a Marcoule, une etude a ete conduite a Saclay, sur des effluents synthetiques - type Marcoule - ayant pour but de mettre au point des procedes d'elimination selective du Sr d'une part, du Cs d'autre part, par coprecipitation. 5) Dans le cas general du rejet ultime en riviere, les problemes suivants sont successivement envisages: - predilution entre les bassins de stockage des eaux epurees et le fleuve; - mode d'injection dans le fleuve; - dilution dans le fleuve (etude prealable par traceurs); - evolution de l'activite dans les eaux du fleuve (adsorption par les organismes inertes ou vivants, contamination des berges); - incidence sur le choix d'un site; - dilution isotopique. 6) Ce dernier probleme est specialement detaille. 7) La teneur de l'eau en un element donne conditionne la dilution isotopique de son isotope radioactif. L'analyse decelant une carence, il est possible d'y suppleer par des rejets d'isotope stable. 8) Cette methode conduit en certains cas a des analyses delicates (en particulier dans le cas du {sup 90}Sr), la teneur en isotope stable necessaire a une forte dilution isotopique restant faible (ce qui est d'ailleurs un avantage). 9

  15. Treatment of Radioactive Waste at Japan's Atomic Energy Research Institute; Traitement des Dechets Radioactifs a l'Institut Japonais de Recherches sur l'Energie Atomique; 041e 0411 0420 0410 0411 041e 0422 041a 0410 0420 0410 0414 ; Tratamiento de los Desechos Radiactivos en el Instituto de Investigaciones sobre Energia Atomica del Japon

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Yutaka [University of Toyko (Japan); Japan Atomic Energy Research Institute (Japan); Ito, Masukuni F.; Ishihara, Takehiko; Mitsuishi, Nobuo [Sadahiro Sakata, Japan Atomic Energy Research Institute (Japan)

    1960-07-01

    The paper describes the origin, nature and treatment of the radioactive wastes. The very low-level liquid waste is diluted and released to the sea, while the low- and medium-level liquid waste is treated by flocculation, evaporation and ion-exchange methods. The solid waste is collected and the combustible waste incinerated. (author) [French] Le present memoire decrit l'origine, la nature et le traitement des dechets radioactifs. Les dechets liquides de tres faible activite sont dilues et evacues dans la mer, tandis que les dechets liquides d'activite faible et moyenne sont traites par des methodes de floculation, d'evaporation et d'echange d'ions. Les dechets solides sont rassembles et les dechets combustibles sont incineres. (author) [Spanish] Los aiutores describen el origen y la naturaleza de los desechos radiactivos, asi como los metodos seguidos para su tratamiento. Los desechos liquidos de muy bajo nivel de actividad se diluyen primero y luego se descargan en el mar, en tanto que los desechos liquidos de bajo y mediano nivel se tratan mediante procedimientos de floculacion, evaporacion e intercambio ionico. Los residuos solidos se acopian y los residuos combustibles se incineran. (author) [Russian] V dokumente opisyvajutsja priroda i harakter radioaktivnyh othodov i metody ih obrabotki. Zhidkie othody ochen' nizkoj aktivnosti razbavljajutsja i otvodjatsja v morja, a zhidkie othody nizkoj i srednej aktivnosti obrabatyvajutsja metodami flokkuljacii, vyparivanija i ionnogo obmena. Tverdye othody sobirajutsja i po vozmozhnosti szhigajutsja. (author)

  16. Modelling of nuclear glasses by classical and ab initio molecular dynamics; Modelisation de verres intervenant dans le conditionnement des dechets radioactifs par dynamiques moleculaires classique et ab initio

    Energy Technology Data Exchange (ETDEWEB)

    Ganster, P

    2004-10-15

    A calcium aluminosilicate glass of molar composition 67 % SiO{sub 2} - 12 % Al{sub 2}O{sub 3} - 21 % CaO was modelled by classical and ab initio molecular dynamics. The size effect study in classical MD shows that the systems of 100 atoms are more ordered than the larger ones. These effects are mainly due to the 3-body terms in the empirical potentials. Nevertheless, these effects are small and the structures generated are in agreement with experimental data. In such kind of glass, we denote an aluminium avoidance and an excess of non bridging oxygens which can be compensated by tri coordinated oxygens. When the dynamics of systems of 100 and 200 atoms is followed by ab initio MD, some local arrangements occurs (bond length, angular distributions). Thus, more realistic vibrational properties are obtained in ab initio MD. The modelling of thin films shows that aluminium atoms extend to the most external part of the surface and they are all tri-coordinated. Calcium atoms are set in the sub layer part of the surface and they produce a depolymerization of the network. In classical MD, tri-coordinated aluminium atoms produce an important electric field above the surface. With non bridging oxygens, they constitute attractive sites for single water molecules. (author)

  17. Elusloom lennukiga puhkusele / Inge Parring

    Index Scriptorium Estoniae

    Parring, Inge

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid

  18. Cadarache LOR (liquides organiques radioactifs) treatment by a solidification process using NOCHAR polymers

    International Nuclear Information System (INIS)

    Vaudey, Claire-Emilie; Renou, Sebastien; Kelley, Dennis; Cochaud, Chantal; Serrano, Roger

    2013-01-01

    In France, two options can be considered to handle the Very Low Level Waste (VLLW) and the Low Level Waste (LLW). The first one is the incineration at CENTRACO facility and the second one is the disposal at ANDRA sites. The waste acceptance in these two channels is dependent upon the adequacy between the waste characteristics (physical chemistry and radiological) and the channel specifications. If the waste characteristics and the channel specifications (presence of significant quantities of halogens, complexing agents, organic components... or/and high activity limits) are incompatible, an alternative solution have to be identify. It consists of a waste pre-treatment process. For Cadarache LOR (Liquides Organiques Radioactifs) waste streams, two radioactive scintillation cocktails have to be treated. They are composed of a mix of organic liquids and water: for the first one, 19 % of organic compounds (xylene, mesitylene, diphenyloxazole, TBP...) and 86.9 % of water, and for the second one, 23 % of organic compounds (TBP...) and 77 % of water. They contain halogens (chlorine and fluorine), complexants agents (nitrate, sulphate, oxalate and formate) and have got αβγ spectra with mass activities equal to some 100 Bq/g. Therefore, tritium is also present. As a consequence, in order for storage acceptance at the ANDRA site, it is necessary to pre-treat the waste. An adequate solution seems to be a solidification process using NOCHAR polymers. Indeed, NOCHAR polymers correspond to an important variety of products applied to the treatment of radioactive aqueous and organic liquids (solvent, oil, solvent/oil mixing ...) and sludge through a mechanical and chemical solidification process. For Cadarache LOR, N910 and N960 respectively dedicated to the organic and aqueous liquids solidification are considered. With the N910, the organic waste solidification occurs in two steps. As the organic liquid travels moves through the polymer strands, the strands swell and

  19. NOCHAR Polymers: An Aqueous and Organic Liquid Solidification Process for Cadarache LOR (Liquides Organiques Radioactifs) - 13195

    International Nuclear Information System (INIS)

    Vaudey, Claire-Emilie; Renou, Sebastien; Porco, Julien; Kelley, Dennis; Cochaud, Chantal; Serrano, Roger

    2013-01-01

    To handle the Very Low Level Waste (VLLW) and the Low Level Waste (LLW) in France, two options can be considered: the incineration at CENTRACO facility and the disposal facility on ANDRA sites. The waste acceptance in these radwaste routes is dependent upon the adequacy between the waste characteristics (physical chemistry and radiological) and the radwaste route specifications. If the waste characteristics are incompatible with the radwaste route specifications (presence of significant quantities of chlorine, fluorine, organic component etc or/and high activity limits), it is necessary to find an alternative solution that consists of a waste pre-treatment process. In the context of the problematic Cadarache LOR (Liquides Organiques Radioactifs) waste streams, two radioactive scintillation cocktails have to be treated. The first one is composed of organic liquids at 13.1 % (diphenyloxazol, mesitylene, TBP, xylene) and water at 86.9 %. The second one is composed of TBP at 8.6 % and water at 91.4 %. They contain chlorine, fluorine and sulphate and have got alpha/beta/gamma spectra with mass activities equal to some kBq.g -1 . Therefore, tritium is present and creates the second problematic waste stream. As a consequence, in order for disposal acceptance at the ANDRA site, it is necessary to pre-treat the waste. The NOCHAR polymers as an aqueous and organic liquid solidification process seem to be an adequate solution. Indeed, these polymers constitute an important variety of products applied to the treatment of radioactive aqueous and organic liquids (solvent, oil, solvent/oil mixing etc) and sludge through a mechanical and chemical solidification process. For Cadarache LOR, N910 and N960 respectively dedicated to the organic and aqueous liquids solidification are considered. With the N910, the organic waste solidification occurs in two steps. As the organic liquid travels moves through the polymer strands, the strands swell and immobilise the liquid. Then as the

  20. Par Pond vegetation status 1996

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-12-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995, and into the early spring and late summer of 1996. Communities similar to the pre-drawdown, Par Pond aquatic plant communities continue to become re-established. Emergent beds of maidencane, lotus, waterlily, watershield, and Pontederia are extensive and well developed. Measures of percent cover, width of beds, and estimates of area of coverage with satellite data indicate regrowth within two years of from 40 to 60% of levels prior to the draw down. Cattail occurrence continued to increase during the summer of 1996, especially in the former warm arm of Par Pond, but large beds common to Par Pond prior to the draw down still have not formed. Lotus has invaded and occupies many of the areas formerly dominated by cattail beds. To track the continued development of macrophytes in Par Pond, future surveys through the summer and early fall of 1997, along with the evaluation of satellite data to map the extent of the macrophyte beds of Par Pond, are planned

  1. Containment of Radioactive Waste for Sea Disposal and Fisheries Off the Canadian Pacific Coast; La Mise en Recipients des Dechets Radioactifs en Vue de leur Elimination dans la Mer et la Protection des Pecheries Operant au Large de la Cote Canadienne de l'Ocean Pacifique; 0423 0414 0414 ; Confinamiento de Desechos Radiactivos para su Evacuacion en el Mar, en Relacion con las Pesquerias de la Costa Canadiense del Pacifico

    Energy Technology Data Exchange (ETDEWEB)

    Waldichuk, Michael [Fisheries Research Board of Canada Biological Station, Nanaimo, BC (Canada)

    1960-07-01

    Low-level radioactive waste consists largely of contaminated laboratory trash, larger items of equipment, animal carcasses from biological tracer experiments, active liquids, and some reactor-irradiated materials. A total of 16,288 55-gallon drums of low-level waste has been dumped off the coast of California from 1946 to 1957, inclusive. The major objectives of the criteria for US sea disposal operations have been (1) safety in handling between waste originator and disposal site, and (2) adequate sinking of wastes in the sea. There has been no requirement for integrity of container or contents at depth. Other techniques used or previously suggested for radioactive waste containment, such as canning, adsorption on clay, and integration into glass are described. In order to render a radioactive waste harmless to fish and other aquatic organisms, it must be either (1) isolated from the environment, or (2) dispersed to levels of permissible concentrations. A spherical vault of suitable engineering design, hermetically sealed and able to withstand high pressures, is proposed for low-level and intermediate-level solid waste disposal, as a means of isolating the waste from the environment. Fish may be affected by radioactive waste in their environment through: (1) direct radiation from the disposed radioactive material; (2) ingestion of food organisms containing concentrated radioisotopes; (3) irradiation by water containing radioactive ions or particles; and (4) contamination by bottom materials rich in precipitated radioisotopes. Research necessary before widespread marine disposal of radioactive waste should be permitted is suggested. (author) [French] Les dechets de faible radioactivite sont constitues surtout par des detritus contamines provenant des laboratoires, des accessoires d'assez grande dimension, des carcasses d'animaux ayant servi a des experiences biologiques avec traceurs, des liquides radioactifs et certains materiaux irradies provenant de reacteurs. De

  2. Vote par sondage uniforme incorruptible

    OpenAIRE

    Blanchard , Nicolas

    2016-01-01

    International audience; Introduit en 2012 par David Chaum, le vote par sondage uniforme (random-sample voting) est un protocole de vote basé sur un choix d'une sous-population représentative , permettant de limiter les coûts tout en ayant de nombreux avantages, principalement lorsqu'il est couplé a d'autres techniques comme ThreeBallot. Nous analysons un problème de corruptibilité potentielle où les votants peuvent vendre leur vote au plus offrant et proposons une variation du protocole reméd...

  3. Device for recovering radioactive waste; Dispositif de recuperation d'effluents radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Mas, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-07-01

    The previous system which consisted in the use of metallic reservoirs placed in a concrete-lined pit gave rise to certain incidents due to corrosion or overflowing followed by contamination with serious consequences. The new system presented consists essentially of a standard 3 m{sup 3} reservoir of stainless steel which is fixed in a concrete-lined well, is tubed with stainless steel. Each reservoir has a standard lid on which are placed all the accessory devices, themselves standardized. The new reservoirs offer thus a great degree of security, and are interchangeable; the wells are easy to decontaminate and it is possible to work in a well without any danger of the personnel being irradiated by neighbouring reservoirs. (author) [French] L'ancien systeme de cuves metalliques disposees dans une fosse betonnee a donne lieu a des incidents par corrosion ou debordements suivis de contamination ayant de grosses consequences. Le nouveau systeme presente comporte essentiellement une cuve standard de 7 m{sup 3} en acier inoxydable mise en place et ancree dans un puits betonne et cuvele en acier inoxydable. Chaque cuve comporte un couvercle standard sur lequel sont rassembles tous les dispositifs annexes standardises eux aussi. Les nouvelles cuves sont donc sures, interchangeables, les puits sont faciles a decontaminer et le travail dans un puits est possible sans crainte d'irradiation du personnel par les cuves voisines. (auteur)

  4. [Project for] a high-flux extracted neutron beam reactor [for physicists]; Un [projet de] reacteur a haut flux et faisceaux sortis [pour physiciens

    Energy Technology Data Exchange (ETDEWEB)

    Ageron, P [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1964-07-01

    tubes and the experimental equipment which can support doses much higher than the ones which are biologically permissible. The final part of the communication describes the studies carried out on the realization of a liquid hydrogen cold sink, one of the most important experimental devices envisaged. (authors) [French] Les besoins francais en canaux pour sortie de neutrons de differentes energies sont brievement indiques. L'interet bien connu des neutrons froids (plus de 4 Angstroem) est souligne. Les grandes lignes d'un reacteur permettant de satisfaire les physiciens sont esquissees. Ce sont les suivantes: 1 - Flux dans l'eau lourde du reflecteur de l'ordre de 7. 10{sup 14} thermiques. 2 - Souplesse d'emploi maximum obtenue par: - separation physique du coeur et du reflecteur, - independance des experiences entre elles, - possibilite de modification, sans interruption notable du fonctionnement de la pile, des experiences physiques jusqu'a - et y compris - la nature du reflecteur utilise, - reduction au minimum des protections fixes; emploi largement generalise des protections liquides (eau) et fluidisees (sables). 3 - Continuite technologique aussi grande que possible avec les reacteurs de recherche francais existant ou en construction (SILOE, PEGASE, OSIRIS). 4 - Surete de fonctionnement recherche par la simplicite de conception. 5 - Minimisation des frais de construction. La reduction des frais d'exploitation est recherchee plutot indirectement par la simplicite des solutions et la reduction du personnel d'exploitation, que directement par la minimisation des consommations d'elements combustibles et d'energie. La solution preconisee peut etre decrite comme un reacteur de type piscine a coeur clos, non pressurise, tres sous modere par l'eau legere de refroidissement. Entourant le reacteur, se trouvent un certain nombre de 'canaux boucles' comprenant chacun: - une portion du reflecteur (eau lourde dans l'exemple decrit), - une portion de canal d'extraction de neutrons

  5. Half-life distribution table of radioactive nuclei; Table de distribution des periodes des noyaux radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Gugenberger, P [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires

    1954-07-01

    This table allows to identify an element if its period is known. Data for this table were taken from the half-life values adopted by Hollander, PERLMAN and SEABORG (Rev. mod. Phys., 1953, 22 number 2). Moreover for each nucleus, the mass number, the charge number and the type of decay are given in the table. (author) [French] Cette table permet l'identification d'un element dont la periode est connue. Elle a ete etablie en utilisant les valeurs des periodes donnees par HOLLANDER, PERLMAN et SEABORG dans Rev. mod. Phys., 1953, 25 numero 2. On y trouve en outre, pour chaque nuclide, les caracteristiques suivantes: Z, A, modes de desintegration. (auteur)

  6. Half-life distribution table of radioactive nuclei; Table de distribution des periodes des noyaux radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Gugenberger, P. [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires

    1954-07-01

    This table allows to identify an element if its period is known. Data for this table were taken from the half-life values adopted by Hollander, PERLMAN and SEABORG (Rev. mod. Phys., 1953, 22 number 2). Moreover for each nucleus, the mass number, the charge number and the type of decay are given in the table. (author) [French] Cette table permet l'identification d'un element dont la periode est connue. Elle a ete etablie en utilisant les valeurs des periodes donnees par HOLLANDER, PERLMAN et SEABORG dans Rev. mod. Phys., 1953, 25 numero 2. On y trouve en outre, pour chaque nuclide, les caracteristiques suivantes: Z, A, modes de desintegration. (auteur)

  7. Par Pond Fish, Water, and Sediment Chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond.

  8. Par Pond Fish, Water, and Sediment Chemistry

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond

  9. Sorption Regularities in Behaviour of Fission-Product Elements during Filtration of their Solutions through Ground; Lois de l'Absorption des Elements Radioactifs Lors du Filtrage des Solutions a Travers les Terrains; 0417 0410 041a 041e 041d 0414 ; Leyes de la Absorcion de los Elementos Radiactivos Cuando se Filtran Soluciones a Traves de las Formaciones Geologicas

    Energy Technology Data Exchange (ETDEWEB)

    Spitsyn, V. I.; Balukova, V. D.; Gromov, V. V.; Zakharov, S. I.; Zhagin, B. P.; Spiridonov, F. M.

    1960-07-01

    la nature. Des que la filtration est devenue constante, on a commence a ajouter a la solution des elements radioactifs ; le processus a dure quatre mois. Des forages consecutifs ont permis de recueillir, a des profondeurs differentes, des echantillons du sol qui ont ete analyses en vue de determiner leur teneur en radioelements. Il a ete constate que la diffusion des isotopes radioactifs atteignait une profondeur d'au moins dix metres, et qu'il existait deux zones nettement determinees ou la radioactivite du sol etait plus faible : l'une a la surface du terrain et l'autre au fond atteint par la solution filtree. On a procede en outre a une etude separee de l'absorption du radio-strontium par des absorbants naturels, principalement par les mineraux purs largement repandus dans les diverses terrains. La presence de certaines quantites, meme petites, d'ions de calcium reduit sensiblement le taux d'absorption du radiostrontium. Cependant, en raison de leur composition - toutes les autres conditions etant egales - certaines substances peuvent absorber le strontium en quantites plus elevees que le calcium. La verification sur place de l'absorption et de la migration du radiostrontium a montre que la filtration des solutions radioactives peut se presenter sous deux formes differentes. Elle prend la premiere lorsque les solutions sont deversees dans des terrains sans a l'action du flux d'eau. Le radiostrontium est alors retenu par les terrains. La deuxieme se presente quand les elements radioactifs penetrent directement dans les couches aquiferes. Dans ce cas le radiostrontium est entraine par les courants souterrains et penetre egalement dans les terrains ou sa migration s'accompagne du processus d'absorption et de desorption. (author) [Spanish] Provocando un proceso de filtracion se ha podido estudiar la absorcion de los elementos radiactivos en la naturaleza. En cuanto se inicio la filtracion se anadieron elementos radicativos a la solucion; el proceso se prolongo durante

  10. Problems presented by the filtration and sampling of aerosols in the atomic energy programme; Problemes poses par la filtration et le prelevement des aerosols dans le cadre de l'energie atomique

    Energy Technology Data Exchange (ETDEWEB)

    Cochinal, R [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1959-07-01

    The maximum permissible limits for radioactive aerosols are much lower than those for aerosols encountered in the non-nuclear industries. These limits depend on numerous factors such as: nature of the radiation, half-life, etc. The radioactive aerosols can be prepared by various methods. The filtering of the air in high activity laboratories or in plutonium treatment factories necessitates an installation consisting of: - aspiration filters, - extraction filters of very high efficiency (those used for {alpha} emitter cells: designed to be replaced without incurring contamination risks; those used for {gamma} emitter cells: designed to be replaced by remote control). The filtering in nuclear reactors is also effectuated by filter papers: - the G1 reactor with open circuit: the air coolant is entirely filtered at the entry and on leaving; - the G2, G3 and EDF1 reactors with closed circuits: filtering under pressure of a small portion of the coolant gas. (author) [French] Les limites maxima permises des aerosols radioactifs sont beaucoup plus faibles que celles des aerosols rencontres dans l'industrie classique. Elles dependent de nombreux facteurs tel que: nature du rayonnement, periode radioactive, etc... La formation des aerosols radioactifs est de nature diverse. La filtration des laboratoires de haute activite, ou d'usines d'elaboration de plutonium conduit a des types d'installations comportant: - des filtres d'aspiration; - des filtres d'extraction a rendement extremement eleve (type pour cellules emettrices {alpha} concu pour etre change sans risque de contamination, type pour cellules emettrices {gamma}: concu pour etre change a distance) La filtration des reacteurs nucleaires sont egalement effectuee par des papiers filtres: - reacteur G1 a circuit ouvert: air de refroidissement totalement filtre a l'aspiration et a l'extraction; - reacteurs G2, G3, EDF1: a circuit ferme: filtration sous pression d'une faible partie du gaz de refroidissement. (auteur)

  11. Fisheries Radiobiology and the Discharge of Radioactive Wastes; Radiobiologie des Pecheries et Evacuation des Dechets Radioactifs; 041f 0420 0418 014 ; Radiobiologia de las Pesquerias y Evacuacion de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, F. [Fisheries Radiobiological Laboratory, Ministry of Agriculture, Fisheries and Food (United Kingdom)

    1960-07-01

    In the United Kingdom authorizations to discharge radioactive wastes are granted by the Minister of Housing and Local Government, the Minister of Agriculture, Fisheries and Food, and by the Secretary of State for Scotland. The hazards arising from contamination of aquatic animals and plants concern the Department of Fisheries ; before authorizations to discharge liquid wastes have been given, the Department has made independent forecasts of permissible levels of discharge based on extensive studies carried out in its research vessels and radiobiological laboratory: for example, where fish have been affected this has meant studies of fish populations and fish migration: uptake of radioactivity by fish : public consumption of fish : commercial distribution of affected fish: L.D.{sub 50}: effects of radiation on tissue, etc. In the course of such work there has been close consultation with the Atomic Energy Authority, and agreement with the Atomic Energy Authority about the safety factor to be incorporated during the first two years of discharge. During these two years, monitoring data collected by the Atomic Energy Authority and the Ministry of Agriculture, Fisheries and Food enable checks and revisions of the original estimates to be made, and at the end of that time formal authorizations, based on operating experience, are issued. (author) [French] Au Royaume-Uni, les autorisations d'evacuer des dechets radioactifs sont accordees par le Ministre du logement et de l'administration locale, par le Ministre de l'agriculture, des pecheries et de l'alimentation et par le Secretaire d'Etat pour l'Ecosse. Les risques dus a la contamination des animaux et des plantes aquatiques relevent du Departement des pecheries; avant d'accorder des autorisations d'evacuer des dechets liquides, le Departement a evalue lui-meme les quantites dont l'evacuation pourrait etre admise, en se fondant sur des etudes approfondies qui sont faites dans ses bateaux de recherche et son laboratoire

  12. On the Waste Disposal Potentiality of the Atmosphere; Possibilites d'Elimination des Dechets Radioactifs dans l'Atmosphere; 041a 0412 041e 041f 0414 ; Sobre la Posibilidad de Evacuar Desechos en la Atmosfera

    Energy Technology Data Exchange (ETDEWEB)

    Small, S. H.; Storebo, P. B. [Norwegian Defence Research Establishment (Norway)

    1960-07-01

    The whole scale of atmospheric mixing, transport and removal processes is reviewed. Certain measurements indicate replacement of stratospheric air within about two years, making high-altitude disposal of radioactive waste materials even less attractive than earlier assumed. Deposition of radioactive materials is to some extent systematically non-uniform, and permissible levels of atmospheric radioactivity should be based upon the probable hazards in the most exposed regions, e.g. regions of considerable orographic precipitation. In connexion with the measurement of atmospheric radioactivity, it is pointed out that sampling techniques should cover the probable effects of gradual changes in particle sizes, and removal of particles by settling, impingement and absorption on vegetation and buildings etc. Meteorological problems in connexion with radiation monitoring and warning systems are discussed in relation to reactor operations. Technical details of relatively simple warning systems are given. (author) [French] Les auteurs examinent l'ensemble des processus suivant lesquels les dechets radioactifs sont brasses, transportes et disperses dans les couches atmospheriques. Certaines mesures indiquent que le renouvellement des masses d'air stratospheriques se fait' en moins de deux ans environ; la possibilite d'eliminer les dechets radioactifs dans les couches superieures de l'atmosphere semble donc encore moins seduisante qu'elle ne le paraissait tout d'abord. On peut dire que, dans une certaine mesure, le depot des substances radioactives s'effectue systematiquement de facon non uniforme; pour determiner le taux de radioactivite atmospherique admissible, il faut donc se baser sur les risques probables encourus dans les regions les plus exposees, par exemple dans les regions a fortes precipitations orographiques. En ce qui concerne la mesure de la radioactivite atmospherique, les techniques d'echantillonnage devraient tenir compte des consequences probables de la

  13. Detection of atmospheric tritium by scintillation. Variations in its concentration in France; Detection du tritium atmospherique par scintillation. Evolution de sa concentration en France

    Energy Technology Data Exchange (ETDEWEB)

    Bibron, R [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-06-01

    The tritium released into the atmosphere as a result of the explosion of thermonuclear devices is a useful radioactive tracer for the study of certain geophysical problems. The low concentrations found however call for the use of extremely sensitive detectors. Two detection methods using liquid scintillators are described. In the first method, the sample is introduced into the scintillator in liquid form, after prior concentration of the tritium by electrolysis. In the second method the tritium is incorporated into the scintillator solvent molecule by chemical synthesis. In the last part of the report are examined the variations in the tritium concentration in rain-water and of the free hydrogen in the air in France. A discussion is then made of the seasonal variations in the case of rain-water and these are compared to the variations in the strontium-90 concentrations. (author) [French] Le tritium introduit dans l'atmosphere par les explosions d'armes thermonucleaires est un traceur radioactif Interessant pour l'etude de certains problemes de geophysique. Les faibles concentrations rencontrees obligent toutefois a utiliser des detecteurs extremement sensibles. On decrit deux methodes de detection utilisant des scintillateurs liquides. Dans la premiere methode, l'echantillon est introduit dans le scintillateur, sous forme aqueuse, apres une concentration prealable du tritium par electrolyse. Dans la seconde methode, le tritium est incorpore a la molecule du solvant du scintillateur par synthese chimique. Dans la derniere partie du rapport, on examine l'evolution de la concentration du tritium dans les eaux de precipitation et l'hydrogene libre de l'air en France. On discute ensuite les variations saisonnieres dans le cas des eaux de precipitation et on les compare aux variations du strontium 90. (auteur)

  14. Detection of atmospheric tritium by scintillation. Variations in its concentration in France; Detection du tritium atmospherique par scintillation. Evolution de sa concentration en France

    Energy Technology Data Exchange (ETDEWEB)

    Bibron, R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-06-01

    The tritium released into the atmosphere as a result of the explosion of thermonuclear devices is a useful radioactive tracer for the study of certain geophysical problems. The low concentrations found however call for the use of extremely sensitive detectors. Two detection methods using liquid scintillators are described. In the first method, the sample is introduced into the scintillator in liquid form, after prior concentration of the tritium by electrolysis. In the second method the tritium is incorporated into the scintillator solvent molecule by chemical synthesis. In the last part of the report are examined the variations in the tritium concentration in rain-water and of the free hydrogen in the air in France. A discussion is then made of the seasonal variations in the case of rain-water and these are compared to the variations in the strontium-90 concentrations. (author) [French] Le tritium introduit dans l'atmosphere par les explosions d'armes thermonucleaires est un traceur radioactif Interessant pour l'etude de certains problemes de geophysique. Les faibles concentrations rencontrees obligent toutefois a utiliser des detecteurs extremement sensibles. On decrit deux methodes de detection utilisant des scintillateurs liquides. Dans la premiere methode, l'echantillon est introduit dans le scintillateur, sous forme aqueuse, apres une concentration prealable du tritium par electrolyse. Dans la seconde methode, le tritium est incorpore a la molecule du solvant du scintillateur par synthese chimique. Dans la derniere partie du rapport, on examine l'evolution de la concentration du tritium dans les eaux de precipitation et l'hydrogene libre de l'air en France. On discute ensuite les variations saisonnieres dans le cas des eaux de precipitation et on les compare aux variations du strontium 90. (auteur)

  15. Conditioning of solid radioactive wastes (1960); Conditionnement des dechets radioactifs solides (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Cerre, P [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    Since solid radioactive wastes are of varied forms, dimensions and volumes, the C.E.A. first reduces the volume by breaking up and compacting. Since these wastes cannot be temporarily stored without contamination risk, an effective packing process has been devised and carried through. This consists in burying the wastes in a specially planned concrete with the following characteristics: - high mechanical resistance; - maximum insolubility; - resistance to corrosion; - maximum imperviousness; - providing protection against radiation. It is then possible to store the blocks safely, with a view to eventual definitive rejection. (author) [French] Les dechets actifs solides etant de formes, de dimensions et de volumes varies, le C.E.A. procede en premier lieu a une reduction de volume par fractionnement et compactage. L'emmagasinage provisoire de tels dechets ne pouvant se concevoir sans risques de contamination, un procede efficace d'emballage a ete etudie et realise. Il consiste a noyer les dechets dans un beton specialement etudie qui presente les caracteristiques suivantes: - forte resistance mecanique; - insolubilite maximum; - resistance a la corrosion; - etancheite maximum; - protection contre le rayonnement. Il est alors possible de conserver sans danger les blocs formes en vue d'un rejet definitif ulterieur. (auteur)

  16. Directed and persistent movement arises from mechanochemistry of the ParA/ParB system.

    Science.gov (United States)

    Hu, Longhua; Vecchiarelli, Anthony G; Mizuuchi, Kiyoshi; Neuman, Keir C; Liu, Jian

    2015-12-22

    The segregation of DNA before cell division is essential for faithful genetic inheritance. In many bacteria, segregation of low-copy number plasmids involves an active partition system composed of a nonspecific DNA-binding ATPase, ParA, and its stimulator protein ParB. The ParA/ParB system drives directed and persistent movement of DNA cargo both in vivo and in vitro. Filament-based models akin to actin/microtubule-driven motility were proposed for plasmid segregation mediated by ParA. Recent experiments challenge this view and suggest that ParA/ParB system motility is driven by a diffusion ratchet mechanism in which ParB-coated plasmid both creates and follows a ParA gradient on the nucleoid surface. However, the detailed mechanism of ParA/ParB-mediated directed and persistent movement remains unknown. Here, we develop a theoretical model describing ParA/ParB-mediated motility. We show that the ParA/ParB system can work as a Brownian ratchet, which effectively couples the ATPase-dependent cycling of ParA-nucleoid affinity to the motion of the ParB-bound cargo. Paradoxically, this resulting processive motion relies on quenching diffusive plasmid motion through a large number of transient ParA/ParB-mediated tethers to the nucleoid surface. Our work thus sheds light on an emergent phenomenon in which nonmotor proteins work collectively via mechanochemical coupling to propel cargos-an ingenious solution shaped by evolution to cope with the lack of processive motor proteins in bacteria.

  17. Study of the diffusion of iron, of silver and of carbon in beryllium using radioactive tracers; Etude de la diffusion du fer, de l'argent et du carbone dans le beryllium au moyen des traceurs radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Naik, M Ch [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-06-01

    A study has been made of the diffusion of radioactive iron and silver tracers in beryllium. The following values have been found. D{sub Fe} = 0.53 exp - [51800 / RT], D{sub Ag} = 62 exp - [46100 / RT]. The values for iron are in good agreement with those found previously for chemical diffusion. A comparison of the diffusion coefficients for iron, silver and nickel shows that the diffusion rate increases with increasing solute atom radius. The existence has been shown of diffusion anisotropy for silver; it has been studied quantitatively on monocrystals. It is found that: D{sub parallel} 0.41 exp - [39100 / RT], D{sub perpendicular} = 1.98 exp - [45700 / RT]. The anisotropy decreases as the temperature increases. The silver diffuses more rapidly along the C axis than in the base plane. This result cannot be explained in terms of the model proposed for the diffusion of foreign atoms in solution in zinc. A greater number of experiments is required before a model can be put forward. An attempt has also been made to determine the diffusion coefficients of carbon in beryllium by treatment in an atmosphere of acetylene marked with C-14. Diffusion coefficients have been obtained but these should not be considered to be very significant since a chemical reaction occurs at the surface of the samples. (author) [French] On a etudie la diffusion dans le beryllium de traceurs radioactifs du fer et de l'argent. On trouve: D{sub Fe} = 0.53 exp - [51800 / RT], D{sub Ag} = 62 exp - [46100 / RT].Les valeurs trouvees pour le fer sont en bon accord avec les valeurs obtenues precedemment pour la diffusion chimique. La comparaison des coefficients de diffusion du fer, de l'argent et du nickel montre que la diffusion est d'autant plus rapide que le rayon atomique du solute est plus grand. On a mis en evidence une anisotropie de diffusion de l'argent qui a ete etudiee quantitativement sur des monocristaux. On trouve: D{sub parallele} = 0.41 exp - [39100 / RT], D{sub perpendiculaire} = 1

  18. Recherche documentaire par titrage automatique

    OpenAIRE

    Lopez , Cédric; Prince , Violaine; Roche , Mathieu

    2011-01-01

    Nous proposons dans cet article un système facilitant la recherche d'information dans un ensemble de documents textuels, basé sur le titrage (et sous-titrage) automatique. Ce dernier peut se révéler crucial, par exemple, dans le cadre de la problématique de l'accessibilité des pages web (norme W3C). Notre processus de titrage automatique consiste à extraire des syntagmes nominaux pertinents dans les textes, pouvant constituer des titres ou sous-titres candidats. Une approche originale combina...

  19. SECHAGE DE PRODUITS GRANULAIRES PAR DESHYDRATATION PAR DETENTES SUCCESSIVES (DDS)

    OpenAIRE

    Abdulla , Galal; Mellouk , Hamid; Belghit , Abdelhamid; Allaf , Karim

    2009-01-01

    International audience; Dans cette étude, nous avons évalué les performances d'un nouveau procédé de séchage dans le cas du liège en granulés. Ce procédé (La déshydratation par détentes successives : DDS) consiste à soumettre le matériau liège dans une chambre hermétique aux variations cycliques de la pression. Chaque cycle est composé d'une compression et d'une décompression. La phase de compression est réalisée en injectant de l'air comprimé à température ambiante provenant d'un compresseur...

  20. Territory of Upper Volta. Interest and Programme of Prospecting for Radioactive Metals; Territoire de la Haute-Volta. Interet et Programme d'une Prospection pour Metaux Radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1958-04-15

    The costs of a programme for prospecting for radioactive metals (esp. Uranium) can amount to a total cost of the order of 600 to 700 millions FF over 10 years. Such a programme represents a rather high risk, because in order to succeed, a reserve capable to pay for the programme must be found in the foreseen period. The first part of the report describes the Uranium reserves already known in Africa. [French] Un programme de prospection pour metaux radioactifs (notamment l'Uranium) pourrait etaler des depenses totales de l'ordre de 600 a 700 millions FF sur 10 ans. Un tel programme represente un risque assez grand, puisque pour reussir, il faut trouver dans le delai envisage, et avec les moyens prevus, un gisement capable d'amortir une telle depense. Une premiere partie du rapport expose les caracteres des gisments d'Uranium actuellement connus en Afrique.

  1. La preuve par le nombre

    Directory of Open Access Journals (Sweden)

    Hélène Verdier

    2012-04-01

    Full Text Available S’il en était besoin, la question des usages et de la finalité des résultats de l’inventaire général pourrait être abordée par le nombre : nombre d’œuvres répertoriées, de communes inventoriées, de clichés photographiques réalisés, de dossiers, de consultations des notices dans les bases de données… Les additions aujourd’hui sont éloquentes, mais elles laissent dans l’ombre le rôle de l’inventaire qui, en mettant en œuvre une démarche systématique de connaissance, participe à l’ identificatio...

  2. Par Pond vegetation status Summer 1995 -- Summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-01-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  3. Disposal of the radioactive effluents at the 'Commissariat a l'Energie Atomique'. Treatment leading to evacuation into a river; Probleme du rejet des residus radioactifs liquides au CEA. Traitements aboutissant a des rejets en riviere

    Energy Technology Data Exchange (ETDEWEB)

    Duhamel; Menoux; Candillon [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    to find out in loaded water, 10) Impot elements other than Sr{sup 90} are also studied. (author) [French] Le probleme du traitement des residus radioactifs liquides au CEA est envisage sous l'angle du rejet ultime en riviere dans des conditions optima permettant de satisfaire aux Normes de la protection. 2) A Saclay, ou l'on ne dispose que d'un etang ou l'eau ne se renouvelle pas, les liquides epures sont envoyes par camion citerne a Fontenay-aux-Roses, ou ils sont deverses provisoirement - dans les egouts - en attendant qu'un point de rejet en Seine ait ete determine. 3) Au Bouchet, les eaux residuaires de l'Usine de traitement de minerais d'urano-thorianite devront etre traitees en deux temps de facon a separer le radium dans une premiere phase, ce qui facilitera l'epuration au cours de la deuxieme phase. 4) En vue des futurs rejets a Marcoule, une etude a ete conduite a Saclay, sur des effluents synthetiques - type Marcoule - ayant pour but de mettre au point des procedes d'elimination selective du Sr d'une part, du Cs d'autre part, par coprecipitation. 5) Dans le cas general du rejet ultime en riviere, les problemes suivants sont successivement envisages: - predilution entre les bassins de stockage des eaux epurees et le fleuve; - mode d'injection dans le fleuve; - dilution dans le fleuve (etude prealable par traceurs); - evolution de l'activite dans les eaux du fleuve (adsorption par les organismes inertes ou vivants, contamination des berges); - incidence sur le choix d'un site; - dilution isotopique. 6) Ce dernier probleme est specialement detaille. 7) La teneur de l'eau en un element donne conditionne la dilution isotopique de son isotope radioactif. L'analyse decelant une carence, il est possible d'y suppleer par des rejets d'isotope stable. 8) Cette methode conduit en certains cas a des analyses delicates (en particulier dans le cas du {sup 90}Sr), la teneur en isotope

  4. ¡París!

    Directory of Open Access Journals (Sweden)

    Beatriz Caballero

    2003-01-01

    Full Text Available El día no le alcanzaba para caminarlo. Conocía cada puente, cada calle,plaza, museo, rincón, iglesia, café, y la mesa con el mejor ángulo para mirar siempre una iglesia, ojalá Saint-Germain-des-Pres, o Notre-Dame. Siempre contaba la impresión que le había causado a Bolívar ver allí cuando el papa coronó a Napoleón. Él se iba para la oficina todos los días, Luis a un taller a pintar, Antonio a estudiar ciencias políticas, yo al colegio y mamá hacía las cosas prácticas. Aprendíamos francés todos al tiempo y por la noche nos contábamos lo nuevo que cada uno había aprendido. Mamá después, cuando ya se quería volver, decía que París nos había maleado a todos. Estaba en pleno furor el cine francés de la "nueva ola", pero ella sólo me llevaba a ver películas de vaqueros pues no se fiaba de la clasificación de los periódicos.

  5. A rapid method of dosing plutonium in radioactive effluents; Methode de dosage rapide du plutonium dans les effluents radioactifs (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Scheidhauer, J; Messainguiral, L [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1961-07-01

    The plutonium is first separated by a lanthanum fluoride precipitation. The precipitated fluorides are dissolved in normal nitric acid solution in the presence of aluminium nitrate. The plutonium transformed to the tetravalent state is then extracted with thenoyltrifluoroacetone and returned to the aqueous phase with 10 N nitric acid. After evaporation on a watch glass the residue is calcined on a Meker burner and counted using a counting system fitted with a zinc sulphide scintillator. When necessary, the calcium is eliminated at the beginning of the dosage by a fluoride precipitation, the plutonium being oxidised to the valency IV. (authors) [French] Le plutonium est d'abord separe par entrainement au fluorure de lanthane. Le precipite des fluorures est remis en solution en milieu acide nitrique normal, en presence de nitrate d'aluminium. Le plutonium amene a la valence IV est alors extrait par la thenoyltrifluoroacetone et remis en phase aqueuse dans l'acide nitrique 10 N. Apres evaporation sur verre de montre, le residu est calcine sur bec Meker et compte sur un ensemble de comptage equipe d'un scintillateur au sulfure de zinc. Lorsque cela est necessaire, le calcium est elimine, au debut du dosage, par precipitation du fluorure, le plutonium etant oxyde a la valence VI. (auteurs)

  6. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  7. The Hydrographical Features of the Baltic Sea and the Disposal of Radioactive Wastes; L'Hydrographie de la Mer Baltique et l'Evacuation des Dechets Radioactifs; 0413 0418 0414 0420 041e 0413 0420 0414 ; Caracteristicas Hidrograficas del Mar Baltico en Relacion con la Evacuacion de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Hela, Ilmo [Institute of Marine Research Helsinki (Finland)

    1960-07-01

    The purpose of the paper is to point out a few hydrographical features of the Baltic Sea, which make this sea, in reference to the disposal of radioactive wastes, different from any oceanic region. The seas can be divided, in reference to the practical problem of the disposal of radionuclides, into the following zones: (1) harbours, (2) fairways leading into harbours, (3) outer continental shelf and (4) the open sea. There, is no open sea, in the above sense, in the Baltic Sea. In addition, the validity of the rules recommended for the above zones, must be carefully checked through further hydrographical studies, since: (1) the whole Baltic is, in a sense, an estuary, with a sill-depth of only 18 metres in the Danish Sounds, (2) the mixing in the Baltic Sea is much more restricted than in the oceans, since the Baltic is rich in islands, brackish, heavily stratified, practically tideless, in winter partly covered with ice, and has a limited fetch of wind and only slowly moving permanent currents. In the paper reference is made to all these factors which diminish the turbulent diffusion, both vertical and horizontal. For the evaluation of the advection and turbulent (eddy) diffusion, both in the upper water layers and at the bottom, synoptic observations of current velocity and salinity at a number of points in several regions of the Baltic Sea and under different weather conditions are needed. (author) [French] Le memoire a pour but d'exposer certains traits de l'hydrographie de la mer Baltique qui, du point de vue de l'evacuation des dechets radioactifs, la distinguent de toute region oceanique. Pour l'etude des problemes pratiques poses par l'evacuation des dechets radioactifs, on peut repartir la mer en quatre zones: 1) les ports, 2) les chenaux d'acces aux ports, 3) le plateau continental, 4) la haute mer. Dans ce sens, il n'y a pas de haute mer dans la Baltique. En outre, la validite des reglements recommandes pour les zones precitees doit faire l'objet d

  8. Use of radioactive tracers in studying the transport of solids in watercourses; Emploi de traceurs radioactifs pour l'etude du transport solide dans les cours d'eau; Ispol'zovanie radioaktivnykh indikatorov dlya izucheniya peremeshcheniya tverdykh chastits v vodnykh potokakh; Empleo de indicadores radiactivos para el estudio del transporte de solidos en las corrientes de agua

    Energy Technology Data Exchange (ETDEWEB)

    Courtois, G [Centre d' Etudes Nucleaires de Saclay (France); Jaeery, P; Heuzel, M [Laboratoire National d' Hydraulique de Chatou (France)

    1962-01-15

    The National Hydraulics Laboratory which, in collaboration with the Saclay Nuclear Research Centre, has for several years been devising equipment and techniques for the study of sediment movements by the radioactive tracer method, is now endeavouring to develop a really quantitative method of research. Two river experiments were recently made, the first a study of shingle drifting in the Rhone, the second a study of sand movement in the Niger. The latter experiment was matched by identical experiments carried out on a scale model of the River Niger which the Chatou Laboratory has at its disposal. The experiments used Mn{sup 56} and Na{sup 24} radiation obtained by direct activation of crushed apricot stone, this representing in the scale model the natural sediment of the Niger bed. The Chatou Laboratory and the Saclay Nuclear Study Centre are at present both devoting attention to the application of radioactive tracers in studies with scale models, with the twin aims of: (a) Obtaining a single research tool for use under natural conditions and with scale models in order to gauge the trustworthiness of the model, in the calibration testing stage; (b) Taking advantage of the facilities for direct observation and measurement offered by scale models in order to study prospects of improving the tracer method, with a view particularly to securing quantitative data. (author) [French] Le Laboratoire national d'hydraulique, qui depuis quelques annees a developpe, en collaboration avec le Centre d'etudes nucleaires de Saclay, les appareillages et les techniques d'etudes des mouvements de sediments par la methode des traceurs radioactifs, s'efforce actuellement de mettre au point un moyen d'investigation veritablement quantitatif. Deux experiences ont ete effectuees recemment en riviere, la premiere a ete consacree a l'etude du charriage des galets dans le Rhone, l'autre a l'etude des transports de sables dans le Niger. Cette derniere experience a ete doublee d

  9. Automatic optimisation of beam orientations using the simplex algorithm and optimisation of quality control using statistical process control (S.P.C.) for intensity modulated radiation therapy (I.M.R.T.); Optimisation automatique des incidences des faisceaux par l'algorithme du simplexe et optimisation des controles qualite par la Maitrise Statistique des Processus (MSP) en Radiotherapie Conformationnelle par Modulation d'Intensite (RCMI)

    Energy Technology Data Exchange (ETDEWEB)

    Gerard, K

    2008-11-15

    Intensity Modulated Radiation Therapy (I.M.R.T.) is currently considered as a technique of choice to increase the local control of the tumour while reducing the dose to surrounding organs at risk. However, its routine clinical implementation is partially held back by the excessive amount of work required to prepare the patient treatment. In order to increase the efficiency of the treatment preparation, two axes of work have been defined. The first axis concerned the automatic optimisation of beam orientations. We integrated the simplex algorithm in the treatment planning system. Starting from the dosimetric objectives set by the user, it can automatically determine the optimal beam orientations that best cover the target volume while sparing organs at risk. In addition to time sparing, the simplex results of three patients with a cancer of the oropharynx, showed that the quality of the plan is also increased compared to a manual beam selection. Indeed, for an equivalent or even a better target coverage, it reduces the dose received by the organs at risk. The second axis of work concerned the optimisation of pre-treatment quality control. We used an industrial method: Statistical Process Control (S.P.C.) to retrospectively analyse the absolute dose quality control results performed using an ionisation chamber at Centre Alexis Vautrin (C.A.V.). This study showed that S.P.C. is an efficient method to reinforce treatment security using control charts. It also showed that our dose delivery process was stable and statistically capable for prostate treatments, which implies that a reduction of the number of controls can be considered for this type of treatment at the C.A.V.. (author)

  10. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

    NARCIS (Netherlands)

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C. Arnold

    2015-01-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced

  11. Determination of mineral radioactive strontium-{sup 90} in urines; Recherche du strontium mineral radioactif {sup 90}Sr dans les urines

    Energy Technology Data Exchange (ETDEWEB)

    Jeanmaire, L; Jammet, H; Bertrand, S [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1959-07-01

    An analytical procedure for radioactive strontium in urine is described. As a first step, a precipitation of calcium oxalate performed on the urine, allows to detect the presence of various fission products and particularly of strontium which is carried by the precipitate. Strontium can then be selectively separated on ion exchange resins. By studying the growth curve of {beta} activity, it is possible to determine the activities which may be attributed to {sup 89}Sr and {sup 90}Sr respectively. (author) [French] Cet article decrit une technique de dosage du strontium radioactif dans les urines. Dans un premier stade, une precipitation d'oxalate de calcium effectuee sur l'urine permet de deceler la presence de differents produits de fission et en particulier du strontium qui est entraine sur ce precipite. Il est possible ensuite de separer selectivement le strontium au moyen de resines echangeuses d'ions. L'examen de le courbe de croissance de l'activite {beta} permet de determiner les activites dues respectivement a {sup 89}Sr et {sup 90}Sr. (auteur)

  12. Use of ion exchange and early treatment of radioactive contamination in the digestive tract; Utilisation des echangeurs d'ions et traitement precoce de la contamination radioactive par voie digestive

    Energy Technology Data Exchange (ETDEWEB)

    Michon, G; Guilloux, M J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    The efficiency of cation exchange resins for the treatment of digestive contamination with strontium has been studied on rats. The results obtained show that the most efficient resins are those of sulfonic type when administered in the ammonium form. The treatment is still efficient when applied 45 minutes after the ingestion of strontium. In the most favourable cases, the radioactivity of the skeleton was lower by a factor 6 in the treated animals than in controls. This easily applicable, rather safe and non specific treatment deserves to be retained for use. (author) [French] Une etude de l'efficacite des resines echangeuses de cations dans le traitement d'une contamination digestive par le strontium a ete entreprise chez le rat. Les resultats montrent que parmi les resines, les plus efficaces sont celles de type sulfonique, administrees sous forme ammonium. Le traitement est encore efficace 45 minutes apres l'ingestion du strontium. Dans les meilleurs cas, le squelette des rats traites etait six fois moins radioactif que celui des temoins. Ce traitement d'emploi facile, peu dangereux, non specifique, merite d'etre retenu. (auteur)

  13. Study of the Fixation and Migration of Radioactive Cations in a Natural Ion Exchanger; Etude de la Fixation et de la Migration de Cations Radioactifs dans un Echangeur d'Ions Naturel; 0418 0417 0423 0427 0415 0414 ; Estudio de la Fijacion y de la Migracion de Cationes Radiactivos en un Cambiador Natural de Iones

    Energy Technology Data Exchange (ETDEWEB)

    Baetsle, L. [Centre d' Etudes de l' Energie Nucleaire, Mol (Belgium)

    1960-07-01

    With a view to utilizing lignite as a natural ion exchanger in the treatment of radioactive waste, a study was made of its physical and physico-chemical properties with reference to ion exchange. The distribution of Sr{sup 90} and Cs{sup 137} ions in the presence of Ca, Na and H was first examined and the equilibrium constants calculated. The kinetics and fixation of ions were then studied, and various parameters required for the calculation of ion-exchange beds were established. Study of the complex phenomenon of radioactive ion migration in the soil was started by the separate investigation of each component ionic equilibrium. (author) [French] Afin d'utiliser le lignite comme echangeur d'ions naturel dans le traitement d'eaux residuaires radioactives, uene etude a ete faite de ses proprietes physiques et physiochimiques, ayant trait a l'echange d'ions. En premier lieu on a etudie la distribution des ions {sup 90}Sr et {sup 137}Cs en presence de Ca, Na et H, et calcule les constantes d'equilibre. En second heu on a traite la cinetique de la fixation des ions, et etabli quelques parametres necessaires au calcul de hts d'echangeurs d'ions. L'etude du phenomene complexe de la migration des ions radioactifs dans le sol a ete abordee par l 'investigation separee de chacun des equilibres ioniques composants. (author) [Spanish] Con objeto de utilizar el lignito como cambiador natural de iones en el tratamiento de aguas residuales radiactivas, se han estudiado sus propiedades fisicas y fisicoquimicas en relacion con el intercambio de iones. En primer lugar, el autor ha estudiado la distribucion de los iones {sup 90}Sr y {sup 137}Cs en presencia de Ca, Na y H, y ha calculado las constantes de equilibrio. En segundo lugar ha estudiado la cinetica de la fijacion de iones y ha establecido algunos parametros necesarios para calcular los lechos de cambiadores de iones. El autor ha abordado el estudio del complejo fenomeno de la migracion de iones radiactivos en el suelo

  14. Management of Waste from the Use of Radioisotopes; Divers Aspects Resultant de l'Utilisation des Isotopes Radioactifs; 0423 0414 0410 041b 0415 041d 0418 0415 041e 0422 0425 041e 0414 ; Diversos Aspectos Relacionados con los Desechos Procedentes del Empleo de Radioisotopos

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, Lester R. [Radiation Safety Branch, Division of Licensing and Regulation, United States Atomic Energy Commission (United States)

    1960-07-01

    The author examines the origin and nature of radioactive waste generated in the use of radioisotopes in industry, medicine, agriculture and research and studies the relationship between types, quantities and uses of radioisotopes and disposal of the radioactive waste generated in their use. He also discusses the methods used for the disposal of such waste under the licensing controls of the United States Atomic Energy Commission. These methods include: 1. The controlled discharge of low concentrations of effluents into streams and into the atmosphere; 2. Controlled release of small quantities of soluble or readily dispersible waste products into sanitary sewage systems; 3. Burial, under controlled conditions, of small quantities of waste in the soil ; 4. Return to AEC installations of radioactive waste for storage or land burial ; 5. Treatment by incineration; and 6. Disposal of packaged waste at sea. The paper reviews the criteria and regulatory requirements applicable to cach method of disposal to accomplish the objective of preventing the waste from entering the food chain of man in hazardous quantities, or of adversely affecting the use of the environment by man. It goes on to discuss the limitations on the types, quantities, and methods of disposal for which private concerns can be licensed due to long-term responsibility for maintenance of burial grounds or storage facilities. (author) [French] L'auteur se propose d'examiner l'origine et la nature des dechets radioactifs resultant de l'utflisation des radioisotopes dans l'industrie, la medecine, l'agriculture et dans les laboratoires de recherche, et d'etudier les rapports qui existent entre les types, les quantites et les utilisations des radioisotopes, d'une part, et les dechets de leur production, d'autre part. Il etudie aussi les methodes utilisees pour l'elimination de ces dechets conformement aux mesures de controle appliquees par la Commission de l'energie atomique des Etats-Unis. Les methodes

  15. Etude du mecanisme de predissociation de l'ion moleculaire de protoxyde d'azote par la mesure de l'energie cinetique des fragments de l'oxyde nitrique et de l'oxygene

    Science.gov (United States)

    Delisle, Claude

    La reaction N2 + O+ ↔ NO + + N, laquelle joue un role important dans la physique de la haute atmosphere, a ete le sujet de plusieurs etudes. Bien que cette reaction ait ete l'objet d'une quantite importante de travaux, ces derniers ne permettent toutefois pas de comprendre entierement le mecanisme d'un point de vue quantique, particulierement les niveaux d'energie excites des fragments qui permettent cette reaction. Puisque cette reaction n'est pas tres facile a reproduire en laboratoire, nous avons utilise la spectroscopie laser sur faisceaux d'ions rapides afin d'explorer les limites de dissociation de l'ion moleculaire intermediaire de cette reaction, a savoir l'ion N2O+. Le faisceau d'ions N2O+ rapides, apres excitation de l'ion moleculaire vers un niveau predissocie de l'etat A2Sigma+, se dissocie pour produire les fragments ioniques O+ et NO+. Par la mesure de la variation du nombre de fragments ioniques en fonction de l'energie cinetique des ions N2O+, nous avons enregistre les spectres de predissociation de l'ion N2O+. Lorsque c'etait possible, nous avons procede a l'analyse de ces spectres de dissociation afin d'en tirer les constantes moleculaires. Pour certaines des transitions rotationnelles intenses, nous avons mesure l'energie cinetique acquise par les fragments lors de la predissociation de l'ion N 2O+. Afin d'analyser les distributions en energie cinetique, nous avons developpe une simulation de l'experience en considerant, entre autres choses, la position des niveaux de vibration et de rotation des fragments diatomiques de chacune des limites de dissociation de N2O+. Les resultats de l'analyse sont exprimes en termes de population des niveaux de vibration des fragments diatomiques pour une distribution donnee de la population des niveaux de rotation des fragments. Les resultats ainsi obtenus, montrent que les fragments diatomiques sont produits dans des niveaux de vibration fortement excites. De tels niveaux d'excitation ne correspondent pas aux

  16. ParA and ParB coordinate chromosome segregation with cell elongation and division during Streptomyces sporulation

    Science.gov (United States)

    Donczew, Magdalena; Mackiewicz, Paweł; Wróbel, Agnieszka; Flärdh, Klas; Zakrzewska-Czerwińska, Jolanta

    2016-01-01

    In unicellular bacteria, the ParA and ParB proteins segregate chromosomes and coordinate this process with cell division and chromosome replication. During sporulation of mycelial Streptomyces, ParA and ParB uniformly distribute multiple chromosomes along the filamentous sporogenic hyphal compartment, which then differentiates into a chain of unigenomic spores. However, chromosome segregation must be coordinated with cell elongation and multiple divisions. Here, we addressed the question of whether ParA and ParB are involved in the synchronization of cell-cycle processes during sporulation in Streptomyces. To answer this question, we used time-lapse microscopy, which allows the monitoring of growth and division of single sporogenic hyphae. We showed that sporogenic hyphae stop extending at the time of ParA accumulation and Z-ring formation. We demonstrated that both ParA and ParB affect the rate of hyphal extension. Additionally, we showed that ParA promotes the formation of massive nucleoprotein complexes by ParB. We also showed that FtsZ ring assembly is affected by the ParB protein and/or unsegregated DNA. Our results indicate the existence of a checkpoint between the extension and septation of sporogenic hyphae that involves the ParA and ParB proteins. PMID:27248800

  17. Contamination potentielle des aliments par des ...

    African Journals Online (AJOL)

    SARA Computers

    la notion de la pollution et de l'exposition aux PCBs, lorsque 77% n'ont pas conscience de cette situation de risque ... 2018). Quoique la contamination par les. PCBs soit de faible niveau, elle est ...... Université Paris-Est, Paris, France ; 183.

  18. CFD analysis of PAR performance as function of inlet design

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kweonha, E-mail: khpark@kmou.ac.kr [Division of Mechanical and Energy systems Engineering, Korea Maritime University, Dongsam-dong, Yeongdo-gu, Busan 606-791 (Korea, Republic of); Khor, Chong Lee, E-mail: itachi_829@hotmail.com [Department of Mechanical Engineering, Korea Maritime University (Korea, Republic of)

    2016-01-15

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  19. CFD analysis of PAR performance as function of inlet design

    International Nuclear Information System (INIS)

    Park, Kweonha; Khor, Chong Lee

    2016-01-01

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  20. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign (March,...

  1. Review of the incineration of 500 tonnes of radio-active residues; Bilan de l'incineration de 500 tonnes de residus radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J; Seyfried, P; Charbonneaux, M [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1969-07-01

    During its first five years operation, the incinerator at the Marcoule Centre has burnt almost 500 tonnes of radio-active residues. Improvements in some of the details of the process have been made during this period; they concern the nature of the materials involved. The technical and radiological results for the installation are very favorable, and have made it possible to maintain a high charge factor.Although the overall economic results are not advantageous in the case of ungraded solid residues this method represents nevertheless the best available for eliminating oils, solvents, wood and dead animals. It can also be of use furthermore each time that a dilution in the atmosphere can advantageously be used as a method of disposing of certain radio elements such as tritium or carbon 14 in the form of gases or vapours. (author) [French] L'incinerateur du Centre de Marcoule a brule, durant les 5 premieres annees de fonctionnement, pres de 500 tonnes de residus radioactifs. Les ameliorations de detail realisees au cours de cette periode ont porte sur la nature des materiaux employes. Les bilans techniques et radiologiques de l'installation sont tres favorables et ont permis de maintenir un facteur de charge eleve. Si le bilan economique n'est pas favorable a l'incineration des residus solides 'tout venant' cette methode constitue cependant la solution ideale pour l'elimination des huiles, des solvants, du bois et des cadavres d'animaux. En outre, elle peut etre interessante chaque fois que la dilution dans l'atmosphere peut etre avantageusement mise a profit pour rejeter certains radioelements tels que le tritium ou le carbone 14 sous forme de gaz ou de vapeurs. (auteur)

  2. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable inflammatory biomarker. In patients, suPAR is a marker of disease presence, severity and prognosis. In the general population, suPAR is predictive of disease development, such as diabetes and cardiovascular disease a...

  3. Copenhagen uPAR prostate cancer (CuPCa) database

    DEFF Research Database (Denmark)

    Lippert, Solvej; Berg, Kasper D; Høyer-Hansen, Gunilla

    2016-01-01

    AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. METHODS...

  4. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle

    2015-01-01

    . This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. METHODS: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating...

  5. Problems raised by radioactive ion acceleration in the SPIRAL project. Accelerator tuning and stabilisation; Problemes poses par l`acceleration d`ions radioactifs dans le project SPIRAL. Reglage et stabilisation de l`accelerateur

    Energy Technology Data Exchange (ETDEWEB)

    Boy, L. [Paris-6 Univ., 75 (France)

    1997-12-31

    This study is related to the SPIRAL project. This facility uses a cyclotron to accelerate radioactive ion beams produced in a thick target by the Grant Accelerateur National d`Ions Lourds primary beam. The low intensity of radioactive beams and the mixing of several species imply special tuning methods and associated diagnostics. Also, a cyclotron and the beam line will be used to switch from this tuning beam to the radioactive one. We present a theoretical study and a numerical simulation of the tuning of five radioactive beams using three different methods. the beam dynamic is performed through the injection beam line and the cyclotron up to the electrostatic deflector. Within the frame of these methods we have described all the SPIRAL beam diagnostics. Construction and test of a new low intensity diagnosis based on a plastic scintillator for phase measurement inside the cyclotron is described in details. (author). 63 refs.

  6. Development of a machine for sorting laundry according to its radioactive contamination (1962); Conception et mise en oeuvre d'une machine a trier le linge en fonction de sa contamination par des produits radioactifs (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Cohendy, G; Alles, M; Pellerin, A [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1962-07-01

    A the Marcoule Plutonium Production Centre special clothing is worn, in the active zones. A large fraction of these clothes is contaminated and must therefore be subjected to specialised treatments during washing in order to be reintroduced subsequently without danger. Because of the large amount of clothes to be treated it has become necessary to install a special semi-automatic machine; the role of the operator is limited to placing the clothing in the machine and to removing the baskets of sorted clothes. The machine itself has been designed and built by the Mechanics Section. The Radiation Protection Service chose the sorting method which is based on {beta} radiation and uses Geiger counters actuating an appropriate electronic system; the Service also developed this system, depending on the various degrees of contamination of the treated clothing. (authors) [French] Le Centre de Production de Plutonium de Marcoule utilise des vetements speciaux pour travailler dans les zones actives. Une proportion importante de ces vetements se contamine et doit, de ce fait, subir des traitements appropries au cours du lavage, de facon a pouvoir etre reintroduits sans danger dans le circuit d'utilisation. Devant l'importance des quantites a traiter, il est apparu necessaire de mettre en place une machine speciale, semi-automatique; le role de l'operateur, consiste en effet uniquement a introduire le linge dans la machine et a extraire de celle-ci les paniers de linge trie. La Section de Mecanique a concu et realise la machine proprement dite. Le Service de Protection contre les Radiations a choisi le mode de tri qui s'effectue en {beta} a l'aide de compteurs Geiger actionnant une electronique appropriee et a assure la mise au point de cette electronique, en fonction des divers degres de contamination du linge a trier. (auteurs)

  7. Study of radionuclides complexes formation by organic compounds in intermediate and low-level radioactive wastes; Etude de la mobilisation, par des complexants organiques, des radionucleides contenus dans les dechets radioactifs de faible et moyenne activite

    Energy Technology Data Exchange (ETDEWEB)

    Bourbon, X.

    1994-12-01

    In the general framework of the safety of nuclear wastes of low and intermediate activity, we studied the effects of organic compounds on the solubilization of metallic cations. Organic compounds originate from the degradation of cellulose in concrete interstitial waters. Degradation reactions generate a number of products, among which carboxylic acids. These acids are known for their chelating properties. We first analysed the degradation of cellulose in alkaline conditions: we qualitatively and quantitatively determined the degradation products for various reaction progress indices, including a dozen of carboxylic acids. The principal goal of our work was the prediction of the behaviour of metallic cations in such cellulose degradation solutions. Owing the complexity of the system, a priori theoretical calculation are not possible. We have thus decided to choose tetra hydroxy pentanoic acid as a reference compound in order to simulate as accurately as possible the behaviour of more complex acids which contain similar functional groups. We have experimentally determined the complexing properties of this reference acid toward divalent cobalt and copper, and trivalent samarium and europium. Simple and mixed complex (hydroxyl) have been evidenced in alkaline medium. Their stability constants have been determined and extrapolated at zero ionic strength using the SIT theory. These results allowed us to theoretically predict the behaviour of our four reference cations in cellulose degradation products formed in concrete interstitial waters. In parallel, we have measured their solubility in real cellulose degradation solutions. Solubility predictions are correct for transition metals, but not for rare earth cations. In this case the complexes which have been identified with tetra hydroxy pentanoic acid are not stable enough to dissolve metallic hydroxides. In real degradation solutions, other compounds would account for the enhancement of rare earth elements solubility.

  8. Results of several years experiments on the absorption of radioactive strontium and caesium by cultivated plants (1962); Compte rendu d'experiences de plusieurs annees sur l'absorption du strontium et du cesium radioactifs par des plantes cultivees (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Michon, M [Commissariat a l' Energie Atomique, Dept. de Protection Sanitaire, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires; Benard, M; Flanzy, M [Station Centrale de Technologie des Produits Vegetaux, 11 - Narbonne (France); Fioramonti, M; Marty, M [Station Agronomique de Toulouse, 31 (France); Barbier, M; Le Blaye, M; Brossard, M [Societe Centrale d' Agronomie, 78 - Versailles (France)

    1962-07-01

    This report follows on to the report number CEA 1860 and uses results obtained in 1960 to give more precise details concerning the data presented in the preceding report. First results obtained on the vine are given. The Sr absorption coefficient has varied very little from one year to the next and that of caesium has slightly diminished. The values obtained suggest that the concentrations of {sup 90}Sr and {sup 137}Cs in irrigation water should not exceed 1/5 of the maximum permissible concentration in drinking water. (authors) [French] Ce rapport fait suite au rapport CEA 1860 et precise grace aux resultats acquis en 1960 les donnees exprimees dans le precedent rapport. Il y est fait mention des premiers resultats obtenus pour la vigne. Le coefficient d'absorption du Sr a peu varie d'une annee sur l'autre et celui du cesium legerement diminue. Les valeurs obtenues permettent de penser qu'il serait souhaitable que la concentration en {sup 90}Sr et en {sup 137}Cs dans l'eau d'irrigation ne depasse pas le 1/5 de la concentration maxima admissible pour l'eau de boisson. (auteurs)

  9. Radioactive waste combustion / vitrification under arc plasma: thermal and dynamic modelling; Combustion - vitrification de dechets radioactifs par plasma d'arc: modelisation de la thermique et de la dynamique

    Energy Technology Data Exchange (ETDEWEB)

    Barthelemy, B

    2003-07-01

    This thesis concerns the thermal and dynamic modelling for a combustion/vitrification process of surrogate radioactive waste under transferred arc plasma. The writer presents the confinement processes for radioactive waste using arc plasma and the different software used to model theses processes. This is followed by a description of our experimental equipment including a plasma arc reactor and an inductive system allowing the homogenization of glass temperature. A combustion/vitrification test is described. Thermal and material balances were discussed. The temperature fields of plasma arc and the glass frit conductivity are measured. Finally, the writer describes and clarifies the equations solved for the simulations of the electrically plasma arc and the glass melting including the thin layer of glass frit coating the crucible cold walls. The modelling results are presented in the form of spatial distribution of temperature, velocity and volume power... (author)

  10. Radioactive waste combustion-vitrification under arc plasma: thermal and dynamic modelling; Combustion - vitrification de dechets radioactifs par plasma d'arc: modelisation de la thermique et de la dynamique

    Energy Technology Data Exchange (ETDEWEB)

    Barthelemy, B

    2003-06-01

    This thesis concerns the thermal and dynamic modelling for a combustion/vitrification process of surrogate radioactive waste under transferred arc plasma. The writer presents the confinement processes for radioactive waste using arc plasma and the different software used to model theses processes. This is followed by a description of our experimental equipment including a plasma arc reactor and an inductive system allowing the homogenization of glass temperature. A combustion/vitrification test is described. Thermal and material balances were discussed. The temperature fields of plasma arc and the glass frit conductivity are measured. Finally, the writer describes and clarifies the equations solved for the simulations of the electrically plasma arc and the glass melting including the thin layer of glass frit coating the crucible cold walls. The modelling results are presented in the form of spatial distribution of temperature, velocity and voluminal power... (author)

  11. Law project on the radioactive materials and wastes management 2006 recommendations presented by Anne Duthilleul; Projet de loi sur la gestion des matieres et des dechets radioactifs 2006 avis presente par Mme Anne Duthilleul

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    This document provides recommendations on the law project concerning the radioactive material and wastes management. It precises the law objectives, the french particularities concerning the radioactive wastes and materials management, the public debate in France, the evaluation of the researches, the recommendations of the economic and social council. (A.L.B.)

  12. Numerical modeling of the thermomechanical behavior of networks of underground galleries for the storage of the radioactive waste: approach by homogenization; Modelisation numerique du comportement thermomecanique de reseaux de galeries souterraines pour le stockage des dechets radioactifs: Approche par homogeneisation

    Energy Technology Data Exchange (ETDEWEB)

    Zokimila, P

    2005-10-15

    Deep geological disposal is one of the privileged options for the storage of High Level radioactive waste. A good knowledge of the behavior and properties of the potential geological formations as well as theirs evolution in time under the effect of the stress change induced by a possible installation of storage is required. The geological formation host will be subjected to mechanical and thermal solicitations due respectively to the excavation of the disposal tunnels and the release of heat of the canisters of radioactive waste. These thermomechanical solicitations will generate a stress relief in the host layer and disposal tunnels deformations as well as the extension of the damaged zones (EDZ) could cause local and global instabilities. This work aims to develop calculation methods to optimize numerical modeling of the thermoelastic behavior of the disposal at a large scale and to evaluate thermomechanical disturbance induced by storage on the geological formation host. Accordingly, after a presentation of the state of knowledge on the thermomechanical aspects of the rocks related to deep storage, of numerical modeling 2D and 3D of the thermoelastic behavior of individual disposal tunnel and a network of tunnels were carried out by a discrete approach. However, this classical approach is penalizing to study the global behavior of disposal storage. To mitigate that, an approach of numerical modeling, based on homogenization of periodic structures, was proposed. Formulations as numerical procedures were worked out to calculate the effective thermoelastic behavior of an equivalent heterogeneous structure. The model, obtained by this method, was validated with existing methods of homogenization such as the self-consistent model, as well as the Hashin-Shtrikman bounds. The comparison between the effective thermoelastic behavior and current thermoelastic behavior of reference showed a good coherence of the results. For an application to deep geological storage, the effective thermoelastic properties of a network of circular tunnels could be given in 2D for various dimensions of the distance between galleries. (author)

  13. Transversal effects of the space charge in an electrified particle beam (the proton synchrotron Saturne) (1963); Les effets transversaux de la charge d'espace dans les faisceaux de particules electrisees (synchrotron a protons Saturne) (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Faure, J; Gouttefangeas, M; Levy-Mandel, R; Vienet, R; Lago, B; Loeb, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-07-01

    This is a study of the repulsive electrostatic forces existing inside a proton beam focused by the magnetic field of a circular accelerator. The general equation that rules the variation of beam density versus time can be rewritten by a fairly simple reasoning, A numerical method to solve this equation is then developed. The next step is then to find an optimum beam, a gaussian distribution of density being proposed allowing to find an analytical solution to the problem. (authors) [French] On etudie l'action des forces electrostatiques de repulsion qui existent dans un faisceau de protons focalise par le champ magnetique d'un accelerateur circulaire. L'equation generale qui regit la variation de densite du faisceau au cours du temps est retrouvee par un raisonnement simple. On developpe une methode numerique de resolution de cette equation. On pose le probleme de la recherche d'un faisceau optimal et on propose une loi de repartition gaussienne de densite qui permet de trouver une solution analytique au probleme. (auteurs)

  14. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Science.gov (United States)

    Baronian, Grégory; Ginda, Katarzyna; Berry, Laurence; Cohen-Gonsaud, Martin; Zakrzewska-Czerwińska, Jolanta; Jakimowicz, Dagmara; Molle, Virginie

    2015-01-01

    Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  15. Phosphorylation of Mycobacterium tuberculosis ParB participates in regulating the ParABS chromosome segregation system.

    Directory of Open Access Journals (Sweden)

    Grégory Baronian

    Full Text Available Here, we present for the first time that Mycobacterium tuberculosis ParB is phosphorylated by several mycobacterial Ser/Thr protein kinases in vitro. ParB and ParA are the key components of bacterial chromosome segregation apparatus. ParB is a cytosolic conserved protein that binds specifically to centromere-like DNA parS sequences and interacts with ParA, a weak ATPase required for its proper localization. Mass spectrometry identified the presence of ten phosphate groups, thus indicating that ParB is phosphorylated on eight threonines, Thr32, Thr41, Thr53, Thr110, Thr195, and Thr254, Thr300, Thr303 as well as on two serines, Ser5 and Ser239. The phosphorylation sites were further substituted either by alanine to prevent phosphorylation or aspartate to mimic constitutive phosphorylation. Electrophoretic mobility shift assays revealed a drastic inhibition of DNA-binding by ParB phosphomimetic mutant compared to wild type. In addition, bacterial two-hybrid experiments showed a loss of ParA-ParB interaction with the phosphomimetic mutant, indicating that phosphorylation is regulating the recruitment of the partitioning complex. Moreover, fluorescence microscopy experiments performed in the surrogate Mycobacterium smegmatis ΔparB strain revealed that in contrast to wild type Mtb ParB, which formed subpolar foci similar to M. smegmatis ParB, phoshomimetic Mtb ParB was delocalized. Thus, our findings highlight a novel regulatory role of the different isoforms of ParB representing a molecular switch in localization and functioning of partitioning protein in Mycobacterium tuberculosis.

  16. [Ambroise Paré in French literature].

    Science.gov (United States)

    Dumaitre, P

    1995-01-01

    The 16th century by its passionate side has been the favourite one of authors of historical novels in which among the heroes of "cloak and dagger stories" appears sometime Ambroise Paré. Alexandre Dumas (the father) has shown him at the court of Charles IX in La Reine Margot (1845) where he does not however play a great role. On the contrary, Balzac in Le Martyr calviniste (1842) has given him a capital part close to the dying François II, whom he intended to trepanize but had to give up this idea as a consequence of the opposition of the queen-mother Catherine de Médicis. In the present century, Robert Merle in Paris ma bonne ville (Fortune de France, 3, 1980) shows Paré at the time of the Saint Barthélemy.

  17. Par Pond refill water quality sampling

    International Nuclear Information System (INIS)

    Koch, J.W. II; Martin, F.D.; Westbury, H.M.

    1996-08-01

    This study was designed to document anoxia and its cause in the event that the anoxia caused a fish kill. However, no fish kill was observed during this study, and dissolved oxygen and nutrient concentrations generally remained within the range expected for southeastern reservoirs. Par Pond water quality monitoring will continue during the second summer after refill as the aquatic macrophytes become reestablished and nutrients in the sediments are released to the water column

  18. The Public Health Problems of Nuclear Waste Disposal; L'Elimination des Dechets Radioactifs et la Sante Publique; 041f 0420 041e 0414 ; Problemas que Presenta para la Salud Publica la Evacuacion de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Dunster, H. J. [United Kingdom Atomic Energy Authority, Health and Safety Branch (United Kingdom)

    1960-07-01

    The fundamental bases of the control of public health problems in connexion with the disposal of radioactive wastes are the Recommendations of the International Commission on Radiological Protection. These Recommendations cannot be applied directly to the disposal of waste because the released radioactivity rarely reaches man in a direct manner. The setting of maximum permissible discharge rates, therefore, involves a knowledge not only of man's utilization of his environment but also of the diverse processes which govern the behaviour of radioactive materials in that environment. As an example of the way in which the United Kingdom has dealt with these problems the paper discusses the discharge of low-activity liquid wastes into the sea, and refers briefly to the similar problems of assessing discharges into rivers and disposal into the ground or the deep sea. The paper concludes that it is possible to demonstrate without difficulty the safety of most proposed waste-disposal operations but that meticulous investigation and control are necessary whenever substantial amounts of radioactivity are to be released to man's environment. (author) [French] Les donnees de base relatives aux mesure de sante publique touchant l'elimination des dechets radioactifs sont fournies par les recommandations de la Commission internationale de protection radiologique. Mais ces recommandations ne peuvent pas etre directement appliquees a l'elimination des dechets, car il est rare que l'homme se trouve directement expose aux radiations emises. Pour pouvoir fixer, en matiere d'elimination de dechets, un taux maximum admissible, il faut donc connaitre non seulement le comportement de l'homme dans le milieu considere, mais aussi les processus suivant lesquels les matieres radioactives agissent sur ce milieu. Prenant comme exemple ce qui est fait au Royaume-Uni, l'auteur etudie la question de l'evacuation dans la mer de dechets liquides de faible radioactivite et il donne un apercu des

  19. Centromere pairing by a plasmid-encoded type I ParB protein

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

    2007-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes two trans-acting proteins, ParA and ParB, and two cis-acting sites, parC1 and parC2, to which ParB binds cooperatively. ParA is related to MinD and oscillates in helical structures and thereby positions ParB/parC-carrying plasmids regularly......, hence identifying the N terminus of ParB as a requirement for ParB-mediated centromere pairing. These observations suggest that centromere pairing is an important intermediate step in plasmid partitioning mediated by the common type I loci....

  20. Heating of leads casks. An analytical solution to the heat equation made up of a series of Laguerre functions; Echauffement des chateaux de plomb. Une solution analytique a l'equation de la chaleur constituee par une serie de fonctions de Laguerre

    Energy Technology Data Exchange (ETDEWEB)

    Formery, Ph; Gilles, A [Commissariat a l' Energie Atomique, Dir. des Productions, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    The packing used for the transport of highly radioactive materials such as in-pile irradiated rods; have to comply to fairly strict safety standards. They should in particular resist to fire without the radioactive protection being seriously affected. The heating of a transport cask placed in a fire has been calculated by normal automatic computation methods assuming that only thermal radiation is responsible for the heating and that this obeys STEFAN'S law. Simultaneously, a purely analytical treatment has been attempted as follows. The existence of a simple solution, of the Laguerre function type, to the heat equation has been demonstrated. By superposing an infinite number of simple solutions, it is possible to produce a fairly general solution, depending on parameters, which satisfies the initial state and the limiting conditions. The parameters can be adjusted so that the temperature and the flux produced on the shell by this solution satisfy approximately STEFAN'S relationship. (authors) [French] Les emballages qui servent au transport de produits fortement radioactifs, tels que des barreaux irradies dans les piles, doivent satisfaire a des normes de securite assez strictes. Ils doivent, en particulier, resister au feu sans que la protection contre le rayonnement soit sensiblement entamee. L'echauffement, par seul rayonnement thermique suppose obeir a la loi de STEFAN, d'un chateau de transport plonge dans un feu a ete calcule par les methodes habituelles du calcul automatique. Parallelement a ete tentee l'approche purement analytique que voici: Une solution simple, du type fonction de LAGUERRE, a l'equation de la chaleur est mise en evidence. La superposition, en nombre infini, de solutions simples, permet de fabriquer une solution assez generale dependant de parametres, satisfaisant a l'etat initial et aux conditions aux limites. Les parametres peuvent etre ajustes de facon que la temperature et le flux engendres sur la coque par cette solution

  1. Localizing by autoradiography at -195 deg radioactive areas in rats exposed to a high flux of thermal neutrons, importance of phosphorus 32 in consecutive internal irradiation; Localisation par autoradiographie a -195 deg des zones radioactives chez le rat expose a un haut flux de neutrons thermiques, importance du phosphore 32 dans l'irradiation interne consecutive

    Energy Technology Data Exchange (ETDEWEB)

    Chanteur, J; Pellerin, P [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1961-07-01

    Rats weighing 25 g were exposed for 5 mn to a flux of 6.10{sup 12} thermal neutrons/cm{sup 2}/s. Anatomical autoradiography at -195 deg. C has enabled the radioactive organs to be easily localised, to follow in course of time the decrease of radioactivity, and from it to deduce the probable nature of the numerous emitters in question. In particular, the phosphorus 32 has thus appeared to be one of those responsible for internal irradiation, general, on the one hand, by activating cellular phosphorus, local, on the other, by activating bony phosphates. Owing to this, an accidental irradiation by neutrons might have consequences that are both somatic (elective irradiation of the bone marrow) and genetic (activation of nucleic acids). The gamma spectrometry has confirmed the nature of certain other emitters. (author) [French] Des rats de 25 g ont ete exposes pendant 5 mn a un flux de 6.10{sup 12} neutrons thermiques/cm{sup 2}/s. L'autoradiographie anatomique a -195 deg. C a permis de localiser facilement les organes radioactifs, de suivre dans le temps la decroissance de la radioactivite, et d'en deduire la nature probable des nombreux emetteurs en cause. En particulier, le phosphore 32 est ainsi apparu comme l'un des responsables de l'irradiation interne, d'une part generale par activation du phosphore cellulaire, d'autre part locale par activation des phosphates osseux. Une irradiations accidentelle par neutrons aurait, de ce fait, des consequences a la fois somatiques (irradiation elective de la moelle osseuse) et genetiques (activation des acides nucleiques). La spectrometrie gamma a confirme la nature de certains autres emetteurs. (auteur)

  2. Study of various processes for marking sediments with gold-198; Etude de divers procedes de marquages de sediments par l'or 198

    Energy Technology Data Exchange (ETDEWEB)

    Jeanneau, B [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-12-15

    The use of radioactive isotopes for the study of sediment deposits is based mainly on two methods: marking in the mass - a glass of an element which can be activated replaces the sediment; surface marking - a physico-chemical process is used to deposit a radio-element at the surface of the sediment. The second process is used in particular for sands when it is advantageous to have a large number of particles for statistical analysis. The aim of this work was to develop a rapid and simple method of marking which could be applied on the actual site of the experiment where equipment, may be limited. The method recommended for marking sand with gold-198 is a combination of the Petersen (treatment with tin chloride) and Campbell (treatment with silver) methods combined with prior treatments with nitric acid and caustic soda. Using this method it is possible to deposit 125 mg of gold per kilo of sediment with a yield of 95 per cent (i.e. 10 Ci/kg) using a hydrochloric acid solution containing gold. The problem of the solidity of the deposits, of their value and of their reproducibility is discussed from the point of view of the mineral constitution of the sand. (author) [French] L'utilisation d'isotopes radioactifs pour l'etude des deplacements sedimentaires fait, principalement appel a deux methodes: le marquage massique - un verre contenant un element activable remplace le sediment; le marquage superficiel - un traitement physico-chimique permet de deposer un radioelement a la surface du sediment. Le second procede est surtout employe pour les sables lorsqu'il est utile de disposer d'un grand nombre de grains pour des raisons statistiques. Le but de ce travail etait de mettre au point une methode simple et rapide de marquage pouvant etre appliquee sur le site meme de l'experience pour les utilisateurs disposant d'un equipement limite. Le procede preconise pour le marquage des sables par l'or 198 est une combinaison des methodes Petersen (traitement au chlorure d

  3. Characterization of carbon, nitrogen, oxygen and refractory metals in binary and ternary silicon-based films using ion beam methods; Caracterisation des elements: carbone, azote, oxygene et metal refractaire dans des depots binaires et ternaires a base de silicium par methodes d'analyse utilisant les faisceaux d'ions

    Energy Technology Data Exchange (ETDEWEB)

    Somatri-Bouamrane, R. [Lyon-1 Univ., 69 - Villeurbanne (France). Inst. de Physique Nucleaire]|[Universite Claude Bernard, 69 - Lyon (France)

    1996-12-19

    Ion beam methods (non Rutherford backscattering, nuclear reactions) have been carried out in order to characterize silicon-based films. The cross sections for the reactions {sup 12}C({alpha},{alpha}), {sup 14}N({alpha},{alpha}), {sup 16}O({alpha},{alpha}), {sup 28}Si({alpha},{alpha}) and {sup 14}N({alpha},p) have been measured within 2 and 7 MeV. CVD beta SiC films could be analyzed and the interface between silicon carbide and the (100) silicon substrate was studied. The epitaxial growth of the beta SiC film could be modelled by comparing the results obtained with ion beam analysis, infrared spectroscopy and electron microscopy. Moreover, the stoichiometry of low pressure CVD Me-Si-N (Me=Re, W, Ti, Ta) ternary systems was studied. The evolution of the nitrogen content in W-Si-N systems allowed to study their stability with respect to the annealing conditions. (N.T.)

  4. Childhood Pars Planitis; Clinical Features and Outcomes

    Directory of Open Access Journals (Sweden)

    Homayoon Nikkhah

    2011-01-01

    Full Text Available Purpose: To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease. Methods: Medical records of pediatric patients (less than 16 years of age at diagnosis with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed. Results: Overall, 117 eyes of 61 patients including 51 (83.6% male subjects were included. Mean age at the time of diagnosis was 7.8΁3.2 (range, 3-16 years. Mean best corrected visual acuity (BCVA was 0.88΁0.76 logMAR at presentation which improved to 0.39΁0.51 logMAR at final visit (P<0.001. Endotheliitis was present in 23 (19.6% eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025. Cataract formation (41.9% and cystoid macular edema (19.7% were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002, age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029, absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047 and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046 were significantly associated with final BCVA of 20/40 or better. Conclusion: Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.

  5. Solidification of Radioactive Waste Solutions; Solidification des Effluents Radioactifs; 041e 0422 0412 0415 0420 0416 0414 0415 041d 0418 0415 0420 0410 0414 0418 041e 0410 041a 0422 0418 0412 041d 042b 0425 0421 0411 0420 041e 0421 041d 042b 0425 0420 0410 0421 0422 0412 041e 0420 041e 0412 ; Solidificacion de Efluentes Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Brezhneva, N. E.; Golovanov, Ju. N.; Oziraner, S. N.; Eremin, A. A.; Rozanova, V. N.

    1963-02-15

    This paper sets out the results of experimental development of a method for the solidifaction of radioactive waste solutions, based on the drying and vitrification of precipitates of iron-hydroxide obtained by settling from radioactive solutions. The solidification system is based on the principle of maximum reduction of the waste off-gases after removal of the aerosols and volatile radioactive components. The authors established optimum conditions to obtain a chemically stable glass and succeeded in lowering the temperature for the melting of the glass by modifying the fluxes added. An appreciable drop in the chemical stability of the glass was noted when it was stored for a long time at temperatures above 300 Degree-Sign - 350 Degree-Sign C. The authors studied the leachability of radiocaesium from the glass. They also investigated the volatility of radiocaesium and radio ruthenium in the course of drying and melting and showed that in an atmosphere of carbonic acid gas the volatility of ruthenium completely disappears. Hie volatility of radiocaesium in appreciable quantities becomes noticeable at temperatures above 700 Degree-Sign C and increases as the temperature rises. It is shown that radiocaesium condenses in the drainage tubes at temperatures below 400 Degree-Sign C and is easily washed off by weak solutions of nitric acid and water. Calculations of the heat release from radioactive glass show that the radius of globular glass castings from high-activity materials (10 c/g) must not exceed 25 cm. The paper includes the flowsheet for a process for the drying and vitrification of radioactive sludge by means of a gas- and heat-remover, together with details of the apparatus required. (author) [French] Les auteurs exposent les resultats des recherches qu'ils ont faites, dans leur laboratoire, pour mettre au point une methode de solidification des effluents radioactifs, fondee sur la dessiccation et la vitrification de l'hydroxyde de fer, obtenu par

  6. Origin, Nature, Disposal and Control of Radioactive Wastes Arising from the Use of Radioisotopes; Origine, Nature, Elimination et Controle des Dechets Radioactifs Decoulant de l'Emploi des Radioisotopes; 041f 0420 041e 0414 ; Origen, Naturaleza, Evacuacion y Control de los Desechos Radiactivos Producidos en la Utilizacion de Radioisotopos

    Energy Technology Data Exchange (ETDEWEB)

    Kenny, A. W. [Ministry of Housing and Local Government (United Kingdom)

    1960-07-01

    The paper describes the different types of radioactive waste arising from industrial, medical and scientific uses of radioisotopes. An outline is given of methods used for waste disposal, depending on the content of radioactivity. (author) [French] L'auteur decrit les differents types de dechets radioactifs decoulant de l'utilisation de radioisotopes dans l'industrie, en medecine et dans la science. Il donne un apercu des methodes employees pour l'elimination des dechets selon leur teneur en elements radioactifs. (author) [Spanish] En la memoria se describen los diferentes tipos de desechos radiactivos producidos por la utilizacion industrial, medica y cientifica de los radioisotopos y se hace una exposicion de los metodos empleados para la evacuacion de desechos segun su contenido radiactivo. (author) [Russian] V doklade daetsja opisanie razlichnyh tipov radioaktivnyh othodov, voznikajushhih v rezul'tate promyshlennogo, medicinskogo i nauchnogo ispol'zovanija radioizotopov. Osobo razbirajutsja metody, ispol'zuemye dlja udalenija radioaktivnyh othodov v zavisimosti ot ih radioaktivnosti. (author)

  7. Usefulness of the decay rate in the management of radioactive waste stocks; De l'interet de la decroissance pour la gestion des dechets radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J; Cohendy, G [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1969-07-01

    It became apparent, during first few years operation of the Marcoule Centre, that it was very useful to exploit the natural decay rate of the radioactive element contaminating the waste. The storage of this waste under the best possible conditions in each case, was first of all favorable for the radiological safety point of view; it led, furthermore, to a marked reduction in the cost price since it made it possible to avoid employing protection means which would have proved to be excessively outsize after a few years. Finally, even when the half-life of the radioelements involved seemed to annul any possible advantages of this method, the temporary storage made it possible to develop treatment processes which were unknown at the time. The overall result of this policy is that at the present time over 98 per cent of the solid waste produced by the Marcoule Centre has been processed in such a way that it can, at any moment, be discharged from the site without difficulty. (authors) [French] Des les premieres annees de fonctionnement du Centre de Marcoule, il est apparu qu'il etait extremement benefique de mettre a profit la decroissance naturelle des elements radioactifs contaminant les dechets. Le stockage de ces dechets dans des conditions appropriees a chaque cas d'espece a tout d'abord ete favorable a la surete radiologique; en outre, il a abouti a une reduction sensible des prix de revient, du fait qu'il a evite de mettre en oeuvre des moyens de protection qui se seraient reveles surdimensionnes au bout de quelques annees. Enfin, meme lorsque la periode des radioelements en cause semblait enlever tout interet a cette methode, le stockage d'attente a permis de mettre au point des procedes de traitement inconnus a l'epoque. Le resultat global de cette politique est que, actuellement, plus de 98 pour cent des dechets solides produits depuis l'origine du Centre de Marcoule ont ete conditionnes de telle sorte qu'ils peuvent, a tout moment, etre evacues hors du Site

  8. Storage and Disposal of Solid Radioactive Waste; Stockage et Evacuation des Dechets Radioactifs Solides; 0425 0420 0414 ; Almacenamiento y Evacuacion de Desechos Radiactivos Solidos

    Energy Technology Data Exchange (ETDEWEB)

    Pomarola, J. [Chef du Bureau Technique, Service de Controle des Radiations et de Genie Radioactif, Commissariat a l' Energie Atomique, Saclay (France)

    1960-07-01

    This paper deals with solutions for the problem of final disposal of solid radioactive waste. I. It is first essential to organize a proper system of temporary storage. II. Final Storage In order to organize final storage, it is necessary to fix, according to the activity and form of the waste, the site and the modes of transport to be used within and outside the nuclear centre. The choice of solutions follows from the foregoing essentials. The paper then considers, in turn, final storage, on the ground, in the sub-soil and in the sea. Economic considerations are an important factor in determining the choice of solution. (author) [French] La presente communication a pour objet les solutions envisagees pour une destination finale des dechets radioactifs solides. I - Il est tout d'abord necessaire de prevoir un stockage provisoire organise. II - Stockage definitif: La realisation d'un stockage definitif rend necessaire, en fonction de l'activite et du conditionnement des dechets, la definition: - du site et des modes de transports envisages a l'interieur et a l'exterieur des Centres Nucleaires. Le choix des solutions decoule des imperatifs ci-dessus et on examine successivement le stockage definitif: - sur le sol, - dans le sous-sol, - en mer. Les considerations d'ordre economique constituent un facteur important dans le choix de la solution. (author) [Spanish] El autor de la memoria estudia las diferentes soluciones previstas para la evacuacion definitiva de los desechos radiactivos solidos. I - Antes que nada hay que preparar un almacenamiento provisional organizado. II - Evacuacion definitiva : Para organizar la evacuacion definitiva es necesario definir antes, en funcion de la actividad y acondicionamiento de los desechos: - el emplazamiento y la forma de transporte que se piensa utilizar en el interior y en el exterior de los centros nucleares. La eleccion de las diversas soluciones depende de las dos condiciones mencionadas; el autor examina sucesivamente la

  9. Soil contamination. part 1. changes in the humidity of non saturated soils after reject in a limited space. part 2. movements of radioactive ions in non saturated soils after reject in a limited space; Contamination des sols (1. partie). Evolution de l'humidite dans les sols non satures apres rejets sur une surface limitee. (2. partie). Comportement des ions radioactifs dans les sols non satures apres rejets d'eau sur une surface limitee

    Energy Technology Data Exchange (ETDEWEB)

    Rancon, D [Commissariat a l' Energie Atomique, Cadarache (France). Centre d' Etudes Nucleaires

    1972-07-01

    upon the counting rate of radioactivity. This method which have allowed to get various results about {sup 131}I and {sup 85}Sr can be generalized to other radioisotopes and other soils. They are applicable to radiological safety of sites studies : Testing storage plants, estimate of accidents hazards and protection of subterranean waters. (author) [French] II est important, dans les etudes de surete radiologique de sites, de connaitre les mouvements d'eau dans les terrains non satures surmontant la nappe aquifere, cette tranche de terrain aere pouvant servir de protection contre la contamination de la nappe. L'utilisation d'humidimetres a neutrons a permis de construire graphiquement les coupes des etats hydriques du terrain et les evolutions dans le temps du volume du sol mouille a partir d'un rejet affectant une superficie restreinte. On mesure aussi les gradients d'humidite, les cinetiques d'assechement, la capacite de retention du sol et la teneur en eau gravifique suspendue en en equilibre avec la charge d'eau. L'etat hydrique initial influence la vitesse d'infiltration et non la vitesse d'avancement du front d'humectation, on peut donc calculer la quantite d'eau accumulable par le terrain. Apres l'arret du rejet, le volume de sol mouille evolue jusqu'a un etat d'equilibre limite par le front d'humectation, les redistributions d'humidite s'effectuant seulement au sein de ce volume; ainsi, en cas de rejet de liquide radioactif, les ions contaminants resteront confines dans un volume mesurable limite par le front d'humectation. Partie 2. Pour faire suite au rapport sur les mouvements d'eau dans les sols non satures apres rejet sur une surface limitee - CEA R 3635 (1) - on etudie les mouvements des ions radioactifs dans ces sols en utilisant un anion et un cathion caracteristiques: l'iode 131 et le strontium 85. La methode est basee sur la mesure simultanee des fronts d'humidite et d'activite au moyen d'humidimetre a neutrons et d'une sonde d'activite specialement

  10. Études par diffraction de fibres de l'ADN double brin

    Science.gov (United States)

    Forsyth, V. T.; Parrot, I. M.

    2005-11-01

    L'état fibreux est un état naturel pour les molécules de polymère qui ont tendance à adopter des conformations hélicoïdales régulières plutôt que des structures globulaires caractéristiques à de nombreuses protéines. La diffraction de fibres a donc une application étendue pour l'étude d'une grande variété de polymères biologiques et synthétiques. Ce papier a pour objectif d'illustrer l'étendue générale de la méthode et, en particulier, de démontrer l'impact des sources modernes de rayonnement synchrotron et de faisceaux neutroniques.

  11. Accouchement par forceps: indications et pronostic materno-foetal ...

    African Journals Online (AJOL)

    L'accouchement par voie basse, peut être parfois compromis par des facteurs maternels, foetaux ou materno-foetaux nécessitant des moyens thérapeutiques comme le forceps pour achever l'accouchement par voie naturelle. Le forceps, une méthode qui n'est pas sans risque pour la mère et le nouveau-né. Nous avons ...

  12. The study of some thiazinic and indaminic dye syntheses induced by ionising radiation; Etude de quelques syntheses de colorants thianziniques et indaminiques amorcees par les rayonnements ionisants

    Energy Technology Data Exchange (ETDEWEB)

    Balestic, S [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-03-15

    With a view to finding some radiochemical reactions applicable on an industrial scale for evaluating the radioactive waste from nuclear reactors, a systematic study was made of the radiochemical synthesis of thiazinic dyes such as methylene blue and Lauths' violet, on which the first tests were carried out in 1954. The first part of the study concerned the identification and the dosage, during radiolysis, of dyes by means of their absorption spectra after separation from the reaction medium by adsorption chromatography or ion-exchange; other radiolysis products such as ammonium chloride and hydrogen peroxide were also identified. During a later stage by systematically varying the physico-chemical parameters it was possible to determine the most favourable conditions for radio-synthesis; the maximum radiochemical yields obtained had the following values: G (Lauths' violet) 1,65; G (Methylene blue) = 1,75. Furthermore, the study of the influence of variously substituted aminated products on the radiochemical yield showed the possibility of synthesising Bindsehedlers green and Wursters blue by radiochemical methods. Finally the discovery of a fundamental intermediate product, Wursters red, together with the kinetic study of the chemical synthesis of methylene blue made it possible to determine the main stages of the reaction mechanism and to decide which of these stages could be attributed to ionising radiations in the case of the radiochemical synthesis. (author) [French] Dans le but de trouver des reactions radiochimiques susceptibles d'une application industrielle pour valoriser les dechets radioactifs provenant des reacteurs nucleaires, il a ete entrepris une etude systematique de la synthese radiochimique des colorants thiazimiques tels que le Bleu de Methylene et le Violet de Lauth dont les premiers essais ont ete effectues par Loiseleur en 1954. La premiere partie de l'etude a porte sur l'identification et le dosage des colorants formes au cours de la radiolyse

  13. PAR1 activation affects the neurotrophic properties of Schwann cells.

    Science.gov (United States)

    Pompili, Elena; Fabrizi, Cinzia; Somma, Francesca; Correani, Virginia; Maras, Bruno; Schininà, Maria Eugenia; Ciraci, Viviana; Artico, Marco; Fornai, Francesco; Fumagalli, Lorenzo

    2017-03-01

    Protease-activated receptor-1 (PAR1) is the prototypic member of a family of four G-protein-coupled receptors that signal in response to extracellular proteases. In the peripheral nervous system, the expression and/or the role of PARs are still poorly investigated. High PAR1 mRNA expression was found in the rat dorsal root ganglia and the signal intensity of PAR1 mRNA increased in response to sciatic nerve transection. In the sciatic nerve, functional PAR1 receptor was reported at the level of non-compacted Schwann cell myelin microvilli of the nodes of Ranvier. Schwann cells are the principal population of glial cells of the peripheral nervous system which myelinate axons playing an important role during axonal regeneration and remyelination. The present study was undertaken in order to determine if the activation of PAR1 affects the neurotrophic properties of Schwann cells. Our results suggest that the stimulation of PAR1 could potentiate the Schwann cell ability to favour nerve regeneration. In fact, the conditioned medium obtained from Schwann cell cultures challenged with a specific PAR1 activating peptide (PAR1 AP) displays increased neuroprotective and neurotrophic properties with respect to the culture medium from untreated Schwann cells. The proteomic analysis of secreted proteins in untreated and PAR1 AP-treated Schwann cells allowed the identification of factors differentially expressed in the two samples. Some of them (such as macrophage migration inhibitory factor, matrix metalloproteinase-2, decorin, syndecan 4, complement C1r subcomponent, angiogenic factor with G patch and FHA domains 1) appear to be transcriptionally regulated after PAR1 AP treatment as shown by RT-PCR. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Taare Zameen Par and dyslexic savants.

    Science.gov (United States)

    Chakravarty, Ambar

    2009-04-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely 'disinhibits' the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations.

  15. Soudage de bois feuillus par friction rotationnelle

    OpenAIRE

    Belleville, Benoît

    2012-01-01

    Les différentes colles utilisées actuellement par l’industrie du meuble au Canada nécessitent des temps de polymérisation constituant un goulot dans la production des meubles et limitant l’atteinte de la production unitaire. Ces adhésifs synthétiques généralement issus de la pétrochimie nécessitent énormément d’énergie lors de leur confection. L’utilisation de connecteurs métalliques ou plastiques, quant à elle, limite les phases de découpage et sablage subséquentes. La présence d’adhésifs et...

  16. The Application of Existing Oceanographic Knowledge to the Problem of Radioactive Waste Disposal into the Sea; Applicationdes Connaissances Oceanographiques Actuelles au Probleme de l'Elimination de Dechets Radioactifs dans la Mer; 0418 0421 041f 0414 ; Aplicacion de los Conocimientos Oceanograficos Actuales al Problema de la Evacuacion de Desechos Radiactivos en el Mar

    Energy Technology Data Exchange (ETDEWEB)

    Pritchard, D. W. [Johns Hopkins University, Baltimore, MD (United States)

    1960-07-01

    quantites assez importantes de dechets emballes (de l'ordre de plusieurs megacuries par an) sans compromettre l'utilisation par l'homme des produits de la mer. On pourrait eliminer sans danger sur le plateau continental des dechets emballes de faible activite, de l'ordre de plusieurs centaines de curies par an et par lieu d'evacuation. Les navires a propulsion nucleaire peuvent decharger sans trop de risques dans les couches superficielles de la haute mer plusieurs centaines de curies avec les matieres echangeuses d'ions usees. L'auteur etudie en particulier J'influence que peut avoir sur les milieux voisins des rivages et des estuaires l'exploitation de navires a propulsion nucleaire. La troisieme partie du memoire contient l'expose succinct de certaines recherches oceanographiques faites actuellement aux Etats-Unis, et qui peuvent eclairer le probleme de l'elimination des dechets radioactifs. (author) [Spanish] La memoria se divide en tres partes principales. En la primera, el autor expone los criterios seguidos para abordar el problema general de la evacuacion de sustancias radiactivas en el mar. Indica aquellos sectores en los que se requieren conocimientos oceanograficos y estudia sucintamente el estado de nuestros conocimientos actuales en estos sectores. En la segunda parte, los conocimientos oceanograficos existentes se aplican a los problemas de evacuacion de desechos, inclusive sus aspectos fisicos, quimicos y biologicos. El autor demuestra que, sobre la base de los conocimientos oceanograficos actuales, la evacuacion en las profundidades del mar de grandes cantidades (del orden de los megacuries por ano) de desechos envasados puede hacerse sin comprometer la utilizacion del mar y de sus productos por el hombre. Los desechos envasados de baja actividad, en cantidades del orden de varios centenares de curies por ano y por lugar de eliminacion, podran evacuarse en la plataforma continental. Asimismo, podra permitirse la evacuacion en las capas superficiales de la

  17. Radioactive Waste Control at the United Kingdom Atomic Energy Research Establishment, Harwell; Traitement des Dechets Radioactifs au Centre de Recherche sur l'Energie Atomique de Harwell; 041a 041e 041d 0422 0420 041e 041b 042c 0417 0410 0423 0414 ; Control de Desechos Radiactivos en el A.E.R.E., Harwell

    Energy Technology Data Exchange (ETDEWEB)

    Burns, R. H. [United Kingdom Atomic Energy Authority (United Kingdom)

    1960-07-01

    The paper outlines the present practices in the control and treatment of radioactive wastes at Harwell. The large-volume, low-level active liquid effluent is treated by phosphate coagulation methods and, eventually, discharged to the River Thames. The medium-level wastes are segregated and undergo a two-stage chemical treatment followed by passage through columns of Vermiculite. The latter process has been found to be effective in removing radoicaesium, which is not dealt with efficiently by the precipitation methods used. Liquid wastes with a high- activity content are stored and a new plant, incorporating chemical treatment, ion exchange and evaporation, is being installed. The chemical sludges formed in the treatment processes are dumped at sea after de-watering by filtration. The contaminated solid waste is either stored or disposed of at sea. It is important to reduce the volume as much as possible and the methods employed include pressure baling, melting and incineration of combustible matter. Small quantities of activity are discharged to the atmosphere through exhaust stacks. The cleaning of this discharge air is commonly achieved by the use of high-efficiency filters or liquid scrubbing systems. Regular stack monitoring is carried out and this is backed up by a comprehensive district sampling programme. (author) [French] L'auteur decrit les methodes de controle et de traitement des dechets radioactifs qui sont appliquees au Centre de Harwell. Le volume considerable des effluents liquides de faible activite est traite par des methodes de coagulation au moyen des phosphates, puis evacue dans la Tamise. Apres separation, les dechets d'activite moyenne sont soumis a un traitement chimique en deux temps, avant de traverser des colonnes de Vermiculite. On a constate que ce dernier processus eliminait le radio- cesium, ce que les methodes de precipitation utilisees ne permettent pas de faire de maniere efficace. Les dechets liquides d'activite intense sont

  18. TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia

    Science.gov (United States)

    Naeser, Margaret A.; Martin, Paula I.; Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Nicholas, Marjorie; Tormos, Jose M.; Steven, Megan S.; Baker, Errol H.; Pascual-Leone, Alvaro

    2011-01-01

    This study sought to discover if an optimum 1 cm2 area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. PMID:21864891

  19. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  20. Concerning the dynamic instability of actin homolog ParM

    International Nuclear Information System (INIS)

    Popp, David; Yamamoto, Akihiro; Iwasa, Mitsusada; Narita, Akihiro; Maeda, Kayo; Maeda, Yuichiro

    2007-01-01

    Using in vitro TIRF- and electron-microscopy, we reinvestigated the dynamics of native ParM, a prokaryotic DNA segregation protein and actin homolog. In contrast to a previous study, which used a cysteine ParM mutant, we find that the polymerization process of wild type ATP-ParM filaments consists of a polymerization phase and a subsequent steady state phase, which is dynamically unstable, like that of microtubules. We find that the apparent bidirectional polymerization of ParM, is not due to the intrinsic nature of this filament, but results from ParM forming randomly oriented bundles in the presence of crowding agents. Our results imply, that in the bacterium, ParM filaments spontaneously form bipolar bundles. Due to their intrinsic dynamic instability, ParM bundles can efficiently 'search' the cytoplasmic lumen for DNA, bind it equally well at the bipolar ends and segregate it approximately symmetrically, by the insertion of ParM subunits at either end

  1. The protein kinase SIK downregulates the polarity protein Par3

    DEFF Research Database (Denmark)

    Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta

    2018-01-01

    on Par3. Functionally, this mechanism impacts on tight junction downregulation. Furthermore, SIK contributes to the loss of epithelial polarity and examination of advanced and invasive human cancers of diverse origin displayed high levels of SIK expression and a corresponding low expression of Par3...

  2. Technical and Administrative Considerations in the Management of Radioactive Wastes; Considerations Techniques et Administratives Relatives au Traitement des Dechets Radioactifs; 0422 0415 0425 041d 0418 0427 0415 0421 041a 0414 ; Aspectos Tecnicos y Administrativos de la Manipulacion de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Wolman, Abel [Johns Hopkins University, Baltimore, MD (United States); Division of Reactor Development, U.S. Atomic Energy Commission, Washington, DC (United States); Lieberman, Joseph A. [Environmental and Sanitary Engineering Branch, Division of Reactor Development, U.S. Atomic Energy Commission, Washington, DC (United States)

    1960-07-01

    administratifs du traitement des dechets en rattachant cette analyse aux mesures qu'il pourrait etre necessaire de prendre dans l'avenir pour assurer un traitement et un controle efficaces, sur le plan administratif et juridique, des effluents radioactifs resultant de la production d'energie atomique. Les auteurs repartissent tout d'abord en de larges categories les differentes sortes de dechets pour bien souligner que le probleme de leur traitement presente de multiples aspects et qu'on ne saurait en donner une solution unique. Ils examinent rapidement le role des differents milieux dans le choix des methodes de traitement des dechets et definissent les procedes fondamentaux de controle (dilution et dispersion, concentration et confinement). Les auteurs distinguent entre les normes fondamentales de protection radiologique et les criteres de fonctionnement qui doivent etre fixes pour realiser le controle des effluents de facon a veiller a ce que les normes fondamentales soient respectees. Les auteurs examinent les progres realises en matiere de normes et criteres ainsi que l'application de ceux-ci dans l'etablissement de reglements de sante et de securite et la mise au point de procedures administratives et juridiques. A cet egard, ils signalent les avantages que presente, du point de vue de l'opinion publique et du travail administratif, l'utilisation la plus large des textes legislatifs et des procedures administratives dans les services deja crees aux divers echelons de l'autorite. Malgre l'importance des depenses qu'entrainent le traitement et l'elimination des dechets radioactifs, le cout par unite d'energie electrique produite ne represente qu'une partie relativement restreinte du cout total par unite d'energie. Les auteurs indiquent d'autres facteurs economiques qui jouent un role dans la manipulation et l'elimination des dechets, notamment en fonction de l'emplacement de l'usine et du point d'evacuation. En outre, ils examinent d'autres aspects du traitement des dechets

  3. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  4. PARs for combustible gas control in advanced light water reactors

    International Nuclear Information System (INIS)

    Hosler, J.; Sliter, G.

    1997-01-01

    This paper discusses the progress being made in the United States to introduce passive autocatalytic recombiner (PAR) technology as a cost-effective alternative to electric recombiners for controlling combustible gas produced in postulated accidents in both future Advanced Light Water Reactors (ALWRs) and certain U. S. operating nuclear plants. PARs catalytically recombine hydrogen and oxygen, gradually producing heat and water vapor. They have no moving parts and are self-starting and self-feeding, even under relatively cold and wet containment conditions. Buoyancy of the hot gases they create sets up natural convective flow that promotes mixing of combustible gases in a containment. In a non-inerted ALWR containment, two approaches each employing a combination of PARs and igniters are being considered to control hydrogen in design basis and severe accidents. In pre-inerted ALWRs, PARs alone control radiolytic oxygen produced in either accident type. The paper also discusses regulatory feedback regarding these combustible gas control approaches and describes a test program being conducted by the Electric Power Research Institute (EPRI) and Electricite de France (EdF) to supplement the existing PAR test database with performance data under conditions of interest to U.S. plants. Preliminary findings from the EPRI/EdF PAR model test program are included. Successful completion of this test program and confirmatory tests being sponsored by the U. S. NRC are expected to pave the way for use of PARs in ALWRs and operating plants. (author)

  5. Radioactive equilibrium of uranium-bearing ores in some problems of applied geology; Les equilibres radioactifs des menerais uraniferes dans quelques problemes de geologie appliquee

    Energy Technology Data Exchange (ETDEWEB)

    Coulomb, R; Girard, Ph; Goldsztein, M [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1964-07-01

    The state of equilibrium between several nuclides in radioactive relationship is determined with accuracy by the fundamental equations of radioactivity. It can be measured physically and expressed in suitable and internationally adopted units; Equilibrium - disequilibrium of uranium-bearing ores is a fairly complex phenomenon but the problem can be much simplified by well-chosen approximations in various practical field cases. The results of radiometric and radiochemical measurements lead to the interpretation of geochemical anomalies and may be used in the qualitative and quantitative estimation of uranium bearing deposits. (authors) [French] L'etat d'equilibre entre plusieurs radioelements en filiation se definit avec precision par les equations fondamentales de la radioactivite et peut etre determine par des mesures physiques dans des systemes d'unites commodes et internationalement adoptes. Le probleme general equilibre-desequilibre des minerais uraniferes est relativement complexe, mais peut se simplifier largement par des approximations judicieuses dans de nombreux cas particuliers rencontres concretement sur le terrain. Les resultats des mesures radiometriques et radiochimiques permettent l'interpretation des anomalies geochimiques et peuvent servir a l'estimation qualitative et quantitative des gisements de minerais uraniferes. (auteurs)

  6. uPAR as anti-cancer target

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Thurison, Tine

    2011-01-01

    , and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models....

  7. Limnological database for Par Pond: 1959 to 1980

    International Nuclear Information System (INIS)

    Tilly, L.J.

    1981-03-01

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  8. Protease-activated receptor (PAR2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.

    Directory of Open Access Journals (Sweden)

    Lisa G van den Hengel

    Full Text Available AIMS: In collateral development (i.e. arteriogenesis, mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in arteriogenesis in a murine hind limb ischemia model. METHODS AND RESULTS: PAR1-deficient (PAR1-/-, PAR2-deficient (PAR2-/- and wild-type (WT mice underwent femoral artery ligation. Laser Doppler measurements revealed reduced post-ischemic blood flow recovery in PAR2-/- hind limbs when compared to WT, while PAR1-/- mice were not affected. Upon ischemia, reduced numbers of smooth muscle actin (SMA-positive collaterals and CD31-positive capillaries were found in PAR2-/- mice when compared to WT mice, whereas these parameters in PAR1-/- mice did not differ from WT mice. The pool of circulating repair-associated (Ly6C-low monocytes and the number of repair-associated (CD206-positive macrophages surrounding collaterals in the hind limbs were increased in WT and PAR1-/- mice, but unaffected in PAR2-/- mice. The number of repair-associated macrophages in PAR2-/- hind limbs correlated with CD11b- and CD115-expression on the circulating monocytes in these animals, suggesting that monocyte extravasation and M-CSF-dependent differentiation into repair-associated cells are hampered. CONCLUSION: PAR2, but not PAR1, is involved in arteriogenesis and promotes the repair-associated response in ischemic tissues. Therefore, PAR2 potentially forms a new pro-arteriogenic target in coronary artery disease (CAD patients.

  9. Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).

    Science.gov (United States)

    Cunningham, Margaret R; McIntosh, Kathryn A; Pediani, John D; Robben, Joris; Cooke, Alexandra E; Nilsson, Mary; Gould, Gwyn W; Mundell, Stuart; Milligan, Graeme; Plevin, Robin

    2012-05-11

    Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh supply of receptor is required to be mobilized to the cell surface for responsiveness to agonist to be sustained. Unlike other PAR subtypes, the mechanisms regulating receptor trafficking of PAR(4) remain unknown. Here, we report novel features of the intracellular trafficking of PAR(4) to the plasma membrane. PAR(4) was poorly expressed at the plasma membrane and largely retained in the endoplasmic reticulum (ER) in a complex with the COPI protein subunit β-COP1. Analysis of the PAR(4) protein sequence identified an arginine-based (RXR) ER retention sequence located within intracellular loop-2 (R(183)AR → A(183)AA), mutation of which allowed efficient membrane delivery of PAR(4). Interestingly, co-expression with PAR(2) facilitated plasma membrane delivery of PAR(4), an effect produced through disruption of β-COP1 binding and facilitation of interaction with the chaperone protein 14-3-3ζ. Intermolecular FRET studies confirmed heterodimerization between PAR(2) and PAR(4). PAR(2) also enhanced glycosylation of PAR(4) and activation of PAR(4) signaling. Our results identify a novel regulatory role for PAR(2) in the anterograde traffic of PAR(4). PAR(2) was shown to both facilitate and abrogate protein interactions with PAR(4), impacting upon receptor localization and cell signal transduction. This work is likely to impact markedly upon the understanding of the receptor pharmacology of PAR(4) in normal physiology and disease.

  10. The processing and management of wastes from atomic reactors; Nouvelles installations industrielles du C.E.A. pour le traitement des dechets radioactifs liquides et solides

    Energy Technology Data Exchange (ETDEWEB)

    Cerre, P; Mestre, E; Bourdrez, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-07-01

    The policy concerning radioactive wastes studied by all Atomic Centres has led to various procedures which, while apparently numerous, come under a few standard headings. Whether the wastes are in the liquid or solid state their management depends on their physical and chemical nature. The procedure adopted is governed by three general principles: - determination of the most economical means possible of storage and processing by volume reduction; - conversion to a solid compact form; - complete acceptance of the accepted standards at all places and all times. In this communication all the standard solutions adopted and used by the various Centres of the Commissariat a l'Energie Atomique will be examined bearing in mind the preceding remarks. Particular mention will be made of the following: - For liquids, physical, chemical and physico-chemical processing - For solids, decontamination, volume reduction and long-term conditioning techniques. The different procedures for collecting and storing solid wastes before and after processing are also discussed. The paper ends with a brief review of the studies, both technical and economic, being pursued on this subject. (authors) [French] La gestion des dechets etudies par tous les Centres Atomiques a donne lieu a des solutions qui - bien que nombreuses en apparence - se ramenent a quelques solutions types, peu nombreuses. Qu'il s'agisse de dechets solides ou liquides, la nature physique et chimique des dechets conditionne leur mode de gestion. Celle-ci procede de trois principes generaux: - recherche du mode de stockage et de traitement aussi economique que possible par reduction de volume; - mise sous forme compacte solide; - garantie du respect des normes en tous lieux et en tous temps. Dans cette communication, nous examinons toutes les solutions types, compte tenu des remarques precedentes, qui ont ete adoptees et sont utilisees par les differents Centres du Commissariat a l'Energie Atomique. Nous rappelons en

  11. Positron Accumulator Ring (PAR) power supply

    International Nuclear Information System (INIS)

    Fathizadeh, M.

    1995-01-01

    The Positron Accumulator Ring (PAR) consists of 8 dipole magnets connected in series. These magnets are energized via one 12-pulse dc power supply. The power supply consists of four phase controlled half-wave wye group converters. Each of the two half-wave converters are connected through an interphase transformer to obtain a full-wave converter with 120 degrees conduction. The input voltage for these two half-wave converters are 180 degrees apart. The two full-wave converters are connected in parallel through a third interphase transformer. This type of connection of the converters not only provides the required output current, it also improves the input power factor of the power supply. The output of the wye group converters is filtered through a passive L-R-C filter to reduce the ripple content of the output current. At low current values of the power supply the current ripple is high, thus a large filter is needed, which adds to the cost of the power supply, however at high output current levels, the current ripple is less severe. The large size of the filter can be reduced by adding an anti-parallel rectifier diode(D1) to the output of the power supply. A freewheeling diode(D2) is connected before the choke to circulate the current once the power supply is turned off. In order to measure the current in the magnet a high precision, low drift, zero flux current transductor is used. This transductor senses the magnet current which provides a feedback signal to control the gating of the converter's thyristors. A true 14 bit Digital to Analog Converter (DAC) is programmed by the control computer for the required current value, providing a reference for the current regulator. Fast correction of the line transients is provided by a relatively fast voltage loop controlled by a high gain slow response current loop

  12. First-in-human uPAR PET

    DEFF Research Database (Denmark)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive...... for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of (64)Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment...... of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with (64)Cu...

  13. Peptide-Based Optical uPAR Imaging for Surgery

    DEFF Research Database (Denmark)

    Juhl, Karina; Christensen, Anders; Persson, Morten

    2016-01-01

    Near infrared intra-operative optical imaging is an emerging technique with clear implications for improved cancer surgery by enabling a more distinct delineation of the tumor margins during resection. This modality has the potential to increase the number of patients having a curative radical...... tumor resection. In the present study, a new uPAR-targeted fluorescent probe was developed and the in vivo applicability was evaluated in a human xenograft mouse model. Most human carcinomas express high level of uPAR in the tumor-stromal interface of invasive lesions and uPAR is therefore considered...... an ideal target for intra-operative imaging. Conjugation of the flourophor indocyanine green (ICG) to the uPAR agonist (AE105) provides an optical imaging ligand with sufficiently high receptor affinity to allow for a specific receptor targeting in vivo. For in vivo testing, human glioblastoma xenograft...

  14. Contribution de la tomographie par coherence optique au diagnostic ...

    African Journals Online (AJOL)

    Contribution de la tomographie par coherence optique au diagnostic de la neuropathie optique toxique. C.O.A. Abouki, S Alamou, C.R.A. Assavedo, L Odoulami-Yehouessi, I Sounouvou, S Hounnou-Tchabi ...

  15. Nuclear structure of weakly bound radioactive nuclei through elastic and and inelastic scattering on proton. Impacts of the couplings induced by these exotic nuclei on direct reactions; Structure de noyaux radioactifs faiblement lies par diffusions elastiques et inelastiques sur proton. Effets des couplages induits par ces noyaux exotiques sur les reactions directes

    Energy Technology Data Exchange (ETDEWEB)

    Lapoux, V

    2005-09-15

    Information on the structure, spectroscopy and target interaction potentials of exotic nuclei can be inferred by interpreting measured data from direct reactions on proton such as elastic or inelastic scattering of proton (p,p') or one-nucleon transfer reaction (p,d). A series of experimental results has been obtained at the GANIL facilities on the setting composed of the MUST telescope array used for the detection of light charged-particles and of CATS beam detectors. This setting aims at measuring reactions on light proton or deuteron targets through reverse kinematics. Particularly, results on C{sup 10}, C{sup 11} and on direct reactions with the He{sup 8} beam of Spiral are presented. The first chapter is dedicated to the description of the most important theories concerning the nucleus. The experimental tools used to probe the nucleus are reported in the second chapter. The third and fourth chapters present the framework that has allowed us to analyse results from (p,p') and (p,d) reactions on weakly bound exotic nuclei. The last chapter is dedicated to the description of future experimental programs. (A.C.)

  16. The IRSN publishes an assessment of doses received in Japan by external irradiation due to radioactive deposits caused by the Fukushima-Daiichi power plant accident; L'IRSN publie une estimation des doses recues au Japon par irradiation externe due aux depots radioactifs provoques par l'accident de la centrale de Fukushima-Daiichi

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    This document first describes how dry and wet radioactive deposits are formed. It also indicates their main components: iodine 131 and 132, caesium 134, 136 and 137, tellurium 132, and barium 140. It describes the different exposure ways due to radioactive deposits in the environment. A map indicates dose level assessments few tens of kilometres around the Fukushima power plant. A brief comment of this map is proposed

  17. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Directory of Open Access Journals (Sweden)

    Flavien Pillet

    Full Text Available Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  18. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Science.gov (United States)

    Pillet, Flavien; Passot, Fanny Marie; Pasta, Franck; Anton Leberre, Véronique; Bouet, Jean-Yves

    2017-01-01

    Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi) mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  19. Prise en charge des intoxications par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Les signes cliniques étaient dominés par les douleurs (98%) suivies des hémorragies (73,80%) pour les morsures de serpent, la douleur pour les piqures de scorpion (100%) et les oedèmes pour les piqures d'abeilles (100%). Les cas de morsure de serpent ont été traités par le sérum antivenimeux polyvalent. Conclusion: ...

  20. Intoxication par la paraphényléne-diamine

    African Journals Online (AJOL)

    raoul

    9 mars 2011 ... remède contre la douleur par Averbukh [8], ou contre la constipation par Schemesh [9], mais l´utilisation à des fins autolytique reste toujours prédominante. Le tableau clinique de l´intoxication à ... une anurie ayant nécessité le recours à l´hémodialyse. Ce taux de survenue d´IRA anurique est relativement ...

  1. Serum suPAR in patients with FSGS: trash or treasure?

    NARCIS (Netherlands)

    Maas, R.J.H.; Deegens, J.K.J.; Wetzels, J.F.M.

    2013-01-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both

  2. A treatment station for solid radio-active waste at the Saclay nuclear research centre (1962); Station de traitement des dechets radioactifs solides au centre d'etudes nucleaires de Saclay (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Cerre, P; Mestre, E; Lebrun, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    The waste from an atomic centre is very varied in nature, in form, and in activity, going from weakly contaminated laboratory waste to objects actuated in a pile and strongly radioactive. After one year's working of a pilot plant, a factory has been built, in which solide waste is treated and then conditioned in concrete blocks. The present communication describes the treatment and conditioning techniques in this factory which uses to a maximum remotely controlled operation. (authors) [French] Les dechets d'un Centre Atomique sont de natures, de forme et d'activites extremement variees, allant des dechets de laboratoires faiblement contamines, aux dispositifs actives en pile et fortement radioactifs. Apres l'exploitation pendant un an d'une unite pilote, une usine a ete construite dans laquelle les dechets solides sont traites, puis conditionnes en bloc de beton. La presente communication a pour objet la description des techniques de traitement et de conditionnement dans cette usine ou les operations sont au maximum commandees automatiquement et a distance. (auteurs)

  3. Tests of the use of cation exchange organic resins for the decontamination of radioactive aqueous effluents; Essais d'emploi des resines organiques echangeuses de cations pour la decontamination des effluents aqueux radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Bourdrez, Jean; Girault, Jacques; Wormser, Gerald

    1962-12-14

    The authors report tests performed in laboratory and results obtained during an investigation of the use of synthetic ion exchangers for the decontamination of radioactive effluents of moderate activity level and with a non neglectable salt loading. Resins are used under sodium form and regenerated after each fixing operation. Once decontaminated and free of its disturbing ions, the regenerating agent (NaCl) is used for several operations. The authors present the used resins, the treated effluents, describe the tests, and discuss the obtained results [French] Dans ce rapport nous faisons le point des essais et resultats obtenus au laboratoire au cours d'une etude concernant l'utilisation des echangeurs d'ions synthetiques pour la decontamination des effluents radioactifs de niveau d'activite moyenne et de charge en sels non negligeable. Les resines sont employees sous forme sodique et regenerees apres chaque operation de fixation. Le regenerant decontamine et debarrasse de ses ions genants est utilise pour plusieurs operations d'elution. Les seuls residus a stocker proviennent d'une part eventuellement d'un pretraitement de l'effluent, d'autre part, dans tous les cas des precipites consecutifs a la purification de l'eluant dont le traitement chimique est plus aise et donne lieu a des boues beaucoup moins volumineuses qu'une coprecipitation effectuee sur la totalite de l'effluent. (auteurs)

  4. A Study Of The Dilution Of Radio-Active Waste In The Rhone (1961); Etude de la dilution dans le rhone des effluents radioactifs du Centre de Marcoule (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J; Scheidhauer, J; Marichal, M; Court, R [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1961-07-01

    The discharge into the Rhone of liquid radio-active waste from the Marcoule Centre necessitates a large number of measurements, in particular chemical and radio-chemical analysis of the waste, itself and of the waters of the Rhone both above arid below the point of discharge. The results thus obtained during 1960 made it possible to evaluate the total amount of active waste discharged and its dilution in the receiving medium. A statistical study of the results of the analysis of the Rhone waters shows that a satisfactory dilution of the waste occurs rapidly; the experimental results obtained with an experimental discharge of rhodamine are thus confirmed. (authors) [French] Le rejet au Rhone des effluents radioactifs liquides produits sur le Centre de Marcoule donne lieu a un grand nombre de mesures et en particulier d'analyses chimiques et radio-chimiques des effluents eux-memes ainsi que des eaux du Rhone avant et apres rejet. Au cours de l'annee 1960, l'ensemble des resultats ainsi obtenus a permis de dresser un bilan des activites rejetees et de leur dispersion dans le milieu recepteur. Une etude statistique des resultats d'analyses des eaux du Rhone montre qu'une dilution satisfaisante des effluents s'effectue rapidement confirmant ainsi les resultats obtenus lors d'un rejet experimental de rhodamine. (auteurs)

  5. Une terreur par l’image

    Directory of Open Access Journals (Sweden)

    Annie DULONG

    2011-09-01

    Full Text Available Si d’autres événements — Hiroshima, la découverte des camps de concentration, la chute du mur de Berlin — ont, au cours du XXe siècle, marqué suffisamment l’imaginaire pour trouver leur réponse dans des œuvres d’art, le 11 septembre 2001 pose la question de la fictionnalisation autrement : il ne s’agit plus tant de combler les manques de la représentation, liés à l’absence d’images ou au délai dans leur dévoilement, mais bien de composer avec l’omniprésence d’une représentation martelée à la télévision et sur Internet. Que cette représentation soit partielle, tronquée et qu’il lui manque la présence des corps, ces grands absents des photographies et des images tournées par les journalistes, ne change rien au fait que c’est avec le trop-plein que les artistes doivent maintenant négocier.Cet article s’intéresse aux romans qui traitent l’événement de front au lieu de l’aborder sur un mode mineur, et a pour objectif de tracer un portrait de la représentation des médias dans les romans du 11 septembre 2001. Ces romans, outre le fait qu’ils traitent des événements de New York, ont comme point commun un personnage, ou décor : les médias, représentés par la télévision, l’Internet, les photographies de presse, interviennent dans les récits d’une manière significative et témoignent de la force brute des images. À travers une étude de certains des mécanismes à l’œuvre dans The Writing on the Wall (Lynne Sharon Schwartz, Extremely Loud and Incredibly Close (Jonathan Safran Foer, Falling Man (Don DeLillo et A Disorder Peculiar to the Country (Ken Kalfus, il s’agira de proposer des réponses à ces quelques questions : quel rôle les médias jouent-ils, et comment participent-ils au récit ? Quelle pression les images exercent-elles sur les personnages ? Que révèlent les personnages enfants dans leur rapport aux médias ? Quelle critique, finalement, les romans

  6. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-06-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned

  7. Par Pond vegetation status Summer 1995 -- September survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-09-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this mid-September survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maidencane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys during the late growing seasons of 1995, and throughout 1996 and 1997, along with the evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  8. Par Pond vegetation status Summer 1995 -- October survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-11-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this late October survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maiden cane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  9. Temperature Distribution in Radioactive Solid Wastes. Part I - Beta-Active Solids; Repartition des Temperatures dans les Dechets Radioactifs Solides. Partie I - Solides Radioactifs Beta; 0420 0410 0421 041f 0420 0415 0414 ; Distribucion de la Temperatura en los Desechos Radiactivos Solidos. Parte I - Desechos Solidos Emisores de Radiaciones Beta

    Energy Technology Data Exchange (ETDEWEB)

    Kotewale, D. A.; Ganguly, A. K. [Atomic Energy Establishment, Trombay (India)

    1960-07-01

    The paper deals with the calculations for temperature distribution over time in a radioactive sphere and in a finite radioactive cylinder buried in a medium having the same thermal properties. Formulae are given for such calculations. Numerical results on temperature build-up are presented graphically for the cases where the activity is due to beta-emitters such as P{sup 32}, Sr{sup 89}, Cs{sup 135} and Sr{sup 90} + (Y{sup 90}). General graphs for calculation of temperature build-up for any long-lived beta-emitter at certain points of interest in a sphere and in a cylinder of particular dimensions and diffusivity are presented. (author) [French] Ce memoire a trait aux calculs servant a evaluer la variation des temperatures en fonction du temps dans une sphere radioactive et dans un cylindre radioactif limite enfouis dans un milieue ayant les memes proprietes thermiques. Les formules utilisees dans ces calculs sont indiquees. Les resultats numeriques concernant la formation des temperatures sont representes graphiquement pour les cas ou l'activite est due a des emetteurs beta tels que {sup 32}P, {sup 89}Sr, {sup 135}Cs et {sup 90}Sr + ({sup 90}Y). Le memoire contient des abaques pour le calcul de la formation des temperatures dans les emetteurs gamma de longue periode a certains points interessants des spheres et des cylindres ayant des dimensions et une capacite de diffusion particulieres. (author) [Spanish] En la memoria se estudia el calculo de la distribucion de temperaturas en funcion del tiempo en una esfera radiactiva y en un cilindro radiactivo finito enterrados en un medio de identicas propiedades termicas. Se dan formulas para efectuar dicho calculo. En el caso en que la actividad se deba a emisores beta, tales como {sup 32}P, {sup 89}Sr, {sup 135}Cs y {sup 90}Sr + ({sup 90}Y), se representan graficamente los resultados numericos relativos al incremento de ]a temperatura. Asimismo, se proporcionan graficos generales para calcular el incremento de la

  10. [Ambroise Paré, his death and his historians].

    Science.gov (United States)

    Dumaître, P

    2001-01-01

    Ambroise Paré died December the 20th., 1590. What happened after his death and what are we knowing about his life? Never forgotten, though a lack of care, we were waiting till the XIXth. century to get recollection upon a subject sustained only by accounts of his travels. After Percy, a surgeon who tried to write Paré's biography through the "Biographie universelle ancienne et moderne, de Michaud (1822)" and some second rank authors, Malgaigne is the first who inside a printing of the "Oeuvres complétes de Paré (1840-41)" has a fine look upon the question, though his work is incomplete and allows many mistakes. Doctors Chéreau and Jal, an historian, analysing civil status records, gave new information enlarged by doctors Le Paulmier, Turner and the U.S. native Janet Doe.

  11. Keratometric alterations following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy.

    Science.gov (United States)

    Citirik, Mehmet; Batman, Cosar; Bicer, Tolga; Zilelioglu, Orhan

    2009-09-01

    To assess the alterations in keratometric astigmatism following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy. Sixteen consecutive patients were enrolled into the study. Conventional vitrectomy was applied to eight of the cases and 25-gauge transconjunctival sutureless vitrectomy was performed in eight patients. Keratometry was performed before and after the surgery. In the 25-gauge transconjunctival sutureless pars plana vitrectomy group, statistically significant changes were not observed in the corneal curvature in any post-operative follow-up measurement (p > 0.05); whereas in the conventional pars plana vitrectomy group, statistically significant changes were observed in the first postoperative day (p = 0.01) and first postoperative month (p = 0.03). We noted that these changes returned to baseline in three months (p = 0.26). Both 25-gauge transconjunctival sutureless and conventional pars plana vitrectomy are effective surgical modalities for selected diseases of the posterior segment. Surgical procedures are critical for the visual rehabilitation of the patients. The post-operative corneal astigmatism of the vitrectomised eyes can be accurately determined at least two months post-operatively.

  12. Cyclanthaceae no estado do Pará, Brasil Cyclanthaceae in Pará State, Brazil

    Directory of Open Access Journals (Sweden)

    Eduardo da Silva Leal

    2012-12-01

    Full Text Available Cyclanthaceae apresenta distribuição exclusiva na região neotropical sendo bem diversificada nas terras baixas das florestas pluviais tropicais, ocorrendo do sul do México até a Mata Atlântica do sul do Brasil. Consistem de ervas terrestres, epífitas, hemiepífitas ou lianas. O tratamento taxonômico de Cyclanthaceae no Pará foi baseado em coleções de herbário, trabalhos de campo e consulta a bibliografia referente à família. Foram registradas 11 espécies: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. e Thoracocarpus bissectus (Vell. Harling. São apresentadas chave de identificação, descrições e ilustrações das espécies, além de comentários sobre distribuição geográfica, hábitat e período de floração e frutificação.Cyclanthaceae is a family with a distribution exclusively in the Neotropics and is well diversified in lowland rainforests, occurring from southern Mexico to the Atlantic Forest of southern Brazil. The family consists of terrestrial herbs, epiphytes, hemiepiphytes and lianas. This taxonomic treatment of the Cyclanthaceae from the state of Pará was based on herbarium specimens, fieldwork, and the literature. Eleven species were recorded: Asplundia altiscandens E.S. Leal, A. fanshawei (Maguire Harling, A. glandulosa (Gleason Harling, A. heteranthera Harling, A. latifrons (Drude Harling, A. schizotepala Harling, A. xiphophylla Harling, Cyclanthus bipartitus Poit. ex A. Rich., Evodianthus funifer (Poit. Lindm., Ludovia lancifolia Brongn. and Thoracocarpus bissectus (Vell. Harling. An identification key, descriptions and illustrations of species are presented. Additional information on the geographic distribution, habitat, and flowering and

  13. Canning by the diffusion caused by a heated die; Gainage par diffusion par filiere chauffante

    Energy Technology Data Exchange (ETDEWEB)

    Gauthron, M [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1959-07-01

    In this process, the uranium fuel is clad with a zirconium can by passing the element through a die. The operation takes place at a temperature varying between 500 and 1000 deg. C. The heating is obtained by passing low voltage electric current through the can. This process differs from the co-extrusion process in that the uranium is not deformed. The uranium is therefore machined to the final dimensions before canning, it can also be hollow. Two types of processes can be adopted for the extrusion: a) Process in which the binding of the can to the uranium is obtained without diffusion (here the can is at high temperature - subsequently cooled - and the uranium is at a low temperature); b) Process in which uranium-zirconium diffusion is initiated. No matter which process is adopted the element is subsequently heat treated in an over at 800 deg. C in order to obtain the final diffusion. The quality of this diffusion is dependent on the initial state of the surfaces and on the degree of vacuum maintained during the operation. (author) [French] Dans ce procede, la gaine zirconium est plaquee sur le combustible uranium par passage dans une filiere. L'operation a lieu a chaud, a une temperature variant entre 500 et 1000 deg. C. Le chauffage est assure par passage d'un courant basse tension dans la gaine. A la difference du procede de cofilage, l'uranium ne subit pas de deformation durant l'operation. Il est donc prealablement usine aux cotes definitives et peut etre creux. Deux processus sont possibles pendant le passage dans la filiere: a) Obtention d'un frettage de la gaine sur l'uranium sans diffusion (avec une gaine a haute temperature et un tube d'uranium a basse temperature, eventuellement refroidi); b) Obtention d'un commencement de diffusion uranium-zirconium. Quelque soit le processus adopte, la cartouche est ensuite traitee dans un four a 800 deg. C pour obtenir la diffusion definitive. La qualite de celle-ci depend essentiellement des etats de surface initiaux

  14. La projection par plasma : une revue

    Science.gov (United States)

    Fauchais, P.; Grimaud, A.; Vardelle, A.; Vardelle, M.

    are presented in the fields of aeronautics and mechanics. La qualité d'un dépôt projete par plasma dépend de nombreux paramètres que l'on commence à mieux appréhender du fait des progrès de la modélisation et de la métrologie tant des écoulements plasmas que des transferts plasma-particules ou que des conditions d'écrasement et de refroidissement des particules lors de leur impact sur le substrat ou les couches déjà déposées. Les techniques de mesure utilisdes et leurs limitations sont d'abord rappelées tant pour les jets de plasma que pour les particules en vol et l'importance des différents phénomènes intervenant dans les transferts plasma-particules est soulignée : gradients de température et de concentration d'espèces chimiques très élevés autour des particules, effets de propagation de la chaleur, notamment pour les particules céramiques, effet d'évaporation, effet de raréfaction sensible dès la pression atmosphérique. Les problèmes de distribution de taille et de vitesse d'injection des particules sont également abordés car ils conditionnent les distributions de trajectoires et donc le traitement des particules dans le jet de plasma. La génération du plasma montre d'une part 1'influence considérable de l'injection du gaz, de sa nature, du dessin de la chambre d'arc et de la tuyère ainsi que du pompage de l'air ambiant sur la longueur des jets de plasma d'arc et d'autre part les problèmes d'injection pour éviter le couplage avec la décharge dans les jets de plasmas R.E Tout ceci est illustré avec des exemples de dépôt d'alumine, de zircone, de cermet carbure et de nickel. L'écrasement des particules est ensuite abordé avec les problèmes de réactions chimiques, de trempe ultra-rapide et donc de structure cristalline des dépôts, d'adhdsion mais aussi de containtes résiduelles et de leur contrôle via les gradients de température dans les dépôts pendant le tir. Enfin quelques applications actuelles sont pr

  15. Contributions of Geology to the Problem of Radioactive Waste Disposal; Contributions de la Geologie au Probleme de l'Elimination des Dechets Radioactifs; 0412 041a 041b 0410 0414 0413 0415 041e 0414 ; Contribucion de la Geologia a la Resolucion de los Problemas que Plantea la Evacuacion de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Nace, R. L. [Water Resources Division, Geological Survey, Washington 25, DC (United States)

    1960-07-01

    aimed directly at waste disposal problems. (author) [French] La terre est l'objet des etudes geologiques; or, les dechets radioactifs ne peuvent etre disperses ou entreposes que dans ou sur la terre. En ce sens, les problemes relatifs a l'elimination des dechets radioactifs sont avant tout d'ordre geologique. Les Etats-Unis ont applique largement les connaissances geologiques accumulees et certains principes bien etablis aux problemes de l'elimination; le caractere exceptionnel de ces problemes a necessite des recherches qui ont permis d'approfondir considerablement nos connaissances dans des domaines particuliers de la geologie. De nombreux travaux ont porte sur l'etude d'emplacements pour installations nucleaires. Cette etude comporte l'analyse et l'evaluation de facteurs geologiques, topographiques, hydrologiques, geochimiques et sismiques. On a analyse aussi par region les caracteristiques d'ensemble des grandes divisions naturelles des Etats-Unis et les incidences de ces caracteristiques sur l'entreposage et l'elimination des dechets. Parmi les problemes speciaux, on etudie comment se comportent ou pourraient se comporter des dechets ordinaires dans des milieux geologiques determines. D'autres etudes portent sur l'utilisation eventuelle de cavites syncli- nales, de failles stratigraphiques, de bancs de sel et de domes de sel pour l'entreposage et l'isolement des dechets de haute activite. De nombreuses etudes generales et quelques etudes de detail ont ete entreprises sur la radiometrie du milieu ambiant. L'eau naturelle est le facteur critique dans l'elimination des dechets ; on a donc etudie certains processus naturels par lesquels on peut purifier l'eau ou en modifier la composition chimique. Les etudes consacrees aux problemes suivants ont donne des resultats interessants : processus de dispersion et de diffusion dans les eaux souterraines et dans les eaux de surface ; vitesse de circulation des contaminants dans les cours d'eau ; mecanisme d'ecoulement des eaux

  16. Parasitisme de Dacryodes edulis par le genre Tapinanthus ...

    African Journals Online (AJOL)

    SARAH

    31 août 2013 ... Parasitisme de Dacryodes edulis par le genre. Tapinanthus (Loranthaceae) et répartition de la myrmécofaune associée à Logbessou Plateau. (Douala, Cameroun). Massako F1*, Tchatat M2, Mony R3, Ladoh Yemeda CF1, Dibong SD1,4,5. 1Laboratoire de Biologie et Physiologie des Organismes ...

  17. Parasitisme des champs semenciers de cacaoyers par les ...

    African Journals Online (AJOL)

    SARAH

    30 janv. 2015 ... J. Appl. Biosci. Parasitisme des champs semenciers de cacaoyers par les loranthaceae dans la localité de Nkoemvone (sud Cameroun). 7795 to the various clones, Phragmanthera capitata was the most abundant Loranthaceae; the level of parasitism of cacao trees is more important at the cacao trees of ...

  18. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  19. Indications and visual outcome of first hundred pars plana ...

    African Journals Online (AJOL)

    Objective: To review the indications and visual outcome of the first one hundred pars plana vitrectomies performed at the newly established surgical retina unit of Makkah Specialist Eye Hospital, Kano, Kano State, Nigeria. Materials and Methods: Aretrospective chart review was performed. Data recorded from the patient ...

  20. Epuration des effluents industriels par électroflottation Belkacem ...

    African Journals Online (AJOL)

    étudié la séparation de quelques métaux lourds tels que le fer, le nickel, ... the separation of some heavy metals such as iron, nickel, copper, zinc, lead and ... généralement basées sur l'adsorption (par ... Différents essais de concentration en.

  1. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  2. Priapisme induit par la chlorpromazine: A propos de deux cas

    Directory of Open Access Journals (Sweden)

    I. Marrag

    2016-06-01

    Le priapisme veineux est une urgence urologique. Il constitue un des effets secondaires des neuroleptiques parmi les quels la chlorpromazine. Cet effet iatrogène, qui est rare mais grave, doit être connu par les cliniciens afin d’être mieux prévenu pour éviter les séquelles érectiles.

  3. La lecture de Merleau-Ponty par Renaud Barbaras

    Czech Academy of Sciences Publication Activity Database

    Pechar, Jiří

    2015-01-01

    Roč. 11, č. 2 (2015), s. 1-6 ISSN 1336-6556 Institutional support: RVO:67985955 Keywords : Merleau-Ponty * Husserl * phenomenology * linguistics of Ferdinand de Saussure Subject RIV: AA - Philosophy ; Religion http://www.ostium.sk/sk/la-lecture-de-merleau-ponty-par-renaud-barbaras/

  4. Par Pond vegetation status summer 1995 - July survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-07-01

    A survey of the emergent shoreline aquatic plant, communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet (61 meters) above mean sea level, and continued with this July survey. Aquatic plant communities, similar to the pre-drawdown Par Pond communities, are becoming reestablished. Beds of maidencane (Panicum hemitomon), lotus (Nelumbo lutea), water lily (Nymphaea odorata), and watershield (Brasenia schreberi) are now extensive and well established. In addition, within isolated coves, extensive beds of water lilies and spike-rush (Eleocharis sp.) are common. Cattail occurrence has increased since refill, but large beds common to Par Pond prior to the drawdown have not formed. Invasion of willow (Salix sp.) and red maple (Acer rubrum) occurred along the lake shoreline during drawdown. The red maples along the present shoreline are beginning to show evidence of stress and mortality from flooding over the past four months. Some of the willows appear to be stressed as well. The loblolly pines (Pinus taeda), which were flooded in all but the shallow shoreline areas, are now dead. Future surveys are planned for the growing seasons of 1995, 1996, and 1997, along with the evaluation of satellite data for mapping the areal extent of the macrophyte beds of Par Pond

  5. fortification des farines tropicales par l'introduction de proteines ...

    African Journals Online (AJOL)

    2Université d'Abomey Calavy, Faculté des Sciences et Techniques, Bénin ... valeur recommandée par le Codex Alimentarius pour ce type de complément alimentaire destiné aux enfants. ..... neurotransmission, coagulation sanguine et.

  6. Quantitative measurements of small isotopic samples in gaseous mixtures by utilization of some nuclear properties; Etude des possibilites de mesures de faibles quantites de gaz radioactifs dans un melange en utilisant simultanement plusieurs proprietes nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Maragnon, J; Delperie, C

    1967-12-01

    The question is to define the characteristics of a group of measurements allowing the analysis of traces of radioactive rare gases in gas mixtures of different composition. To distinguish the radioactive isotopes from each other and the activity level reaching 10{sup 6} due to their nuclear properties, the method was chosen to use several nuclear properties: gamma radiation energy, beta particle energy, lifetime of excited states. The choice of a plastic scintillator as beta detector allows to answer satisfactorilly to this demand by measurement of nuclear constants because of the short de/excitation time of this detector. Another advantage is that it can be a reservoir for the sample without any destruction nor modification of the sample. The study has been based on the mixture of Kr-85, the analysis of other rare gases follwos immediately from the adopted principle. [French] Les auteurs ont oriente leur recherche vers une solution permettant de distinguer les isotopes radioactifs les uns des autres et dans des rapports d'activite pouvant atteindre 10{sup 6}, grace a plusieurs de leurs proprietes nucleaires, energie de rayonnement gamma, energie de la particule beta, temps de vie des niveaux excites. Le choix d'un scintillateur plastique comme detecteur beta permet de repondre d'une maniere satisfaisante a la mesure des constantes nucleaires en raison du temps de de/excitation rapide de ce scintillateur. Il offre en outre l'avantage de pouvoir servir de reservoir a l'echantillon sans entrainer aucune destruction ni modification de celui-ci. L'etude a ete basee sur la mixture de Kr-85, l'analyse des autre gaz rares decoulant immediatement du principe adopte. (auteur)

  7. Long-term thyroid values after intake of radio-active iodine; Bilans thyroidiens de longue duree apres administration d'iode radioactif

    Energy Technology Data Exchange (ETDEWEB)

    Riviere, R [Institut National de la Sante et de la Recherche Medicale, 75 - Paris (France); Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-07-01

    In connection with a compartment theory, a kinetic study of thyroid metabolism in man requires the determination of the specific iodine activity at all accessible levels (plasma, urines, faeces), during periods of over a month; The basic methods required for such a study are therefore the use of iodine-125 as a tracer, the exact determination of iodine-127 using activation analysis and the setting-up of a daily diet of constant iodine content. The results are presented for each particular case and the main parameters of thyroid metabolism are calculated. The discussion includes some special considerations concerning the pathological condition of the subject or a break in the thyroid equilibrium. It shows in particular that constant disagreement exists between the experimental curves for the specific iodine activity and the corresponding theoretical curves for a conventional thyroid process based on 3 compartments; these discrepancies concern both the inorganic iodine and the organic iodine eliminated with the faeces. (author) [French] Dans le cadre d'une theorie a compartiments, l'etude cinetique du metabolisme thyroidien chez l'homme necessite la determination de l'activite specifique de l'iode a tous les niveaux accessibles (plasma, urines, feces), pendant des periodes depassant un mois. Les methodes de base indispensables pour une telle etude sont donc l'utilisation de l'iode 125 comme traceur, le dosage precis de l'iode 127 grace a l'analyse par activation et l'etablissement d'une diete journaliere constante en iode. Les resultats sont presentes pour chaque cas et les principaux parametres du metabolisme thyroidien calcules. La discussion fait part de considerations particulieres liees a l'etat pathologique du sujet ou a une rupture de l'equilibre thyroidien. Elle met surtout en lumiere des desaccords constants entre les courbes experimentales d'activite specifique de l'iode et les courbes theoriques correspondantes conformes au schema thyroidien classique a 3

  8. The role of pars flaccida in human middle ear sound transmission.

    Science.gov (United States)

    Aritomo, H; Goode, R L; Gonzalez, J

    1988-04-01

    The role of the pars flaccida in middle ear sound transmission was studied with the use of twelve otoscopically normal, fresh, human temporal bones. Peak-to-peak umbo displacement in response to a constant sound pressure level at the tympanic membrane was measured with a noncontacting video measuring system capable of repeatable measurements down to 0.2 micron. Measurements were made before and after pars flaccida modifications at 18 frequencies between 100 and 4000 Hz. Four pars flaccida modifications were studied: (1) acoustic insulation of the pars flaccida to the ear canal with a silicone rubber baffle, (2) stiffening the pars flaccida with cyanoacrylate cement, (3) decreasing the tension of the pars flaccida with a nonperforating incision, and (4) perforation of the pars flaccida. All of the modifications (except the perforation) had a minimal effect on umbo displacement; this seems to imply that the pars flaccida has a minor acoustic role in human beings.

  9. Radio-active colloids in the functional exploration of the reticulo-endothelium system; Les colloides radioactifs dans l'exploration fonctionnelle du systeme reticulo-endothelial

    Energy Technology Data Exchange (ETDEWEB)

    Chivot, J.J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-03-01

    characteristic of its state of activity. The phagocytic index K depends also on the diameter of the colloidal particles injected and can be used as biological test for a colloid: this is the percentage of injected colloid which is retained by the S.R.E. per unit time. This index depends on anaesthetics, on the state of inflammation of the organism and on chemical mediators such as histamine. (author) [French] Un rappel historique met en lumiere le systeme reticulo-endothelial S.R.E. et tente d'en preciser l'identite et le fonctionnememt. Les methodes de son exploration et les colloides utilises sont envisages. L'auteur est amene a fabriquer un colloide d'un type particulier: un complexe albuminique radioiode le 'C.A. {sup 131}I' dont il decrit les etapes de la preparation et des essais tant physiques que biologiques. Une albumine humaine, presentant en solution une densite optique definie est portee a la chaleur jusqu'a modification de la densite optique, temoin d'une agregation des molecules proteiques. La proteine denaturee est iodee par {sup 131}I. Des controles d'electrophorese, d'ultracentrifugation et d'autoradiographie sont effectues. Cette preparation d'origine biologique atoxique et metabolisable sera comparee a l'or colloidal mieux defini qui servira de reference. Le C.A.{sup 131}I est injecte a la souris. Des mesures de radioactivite, des autoradiographies de coupe de l'animal entier, des detections de l'anthropogammametre mettent en evidence une concentration importante au niveau du S.R.E. du foie. Mais ces resultats statiques ont une portee limitee en regard de l'exploitation d'une etude cinetique in vivo du phenomene. L'auteur enregistre les variations de la radioactivite du sang derive de la carotide dans un scintillateur a puits. Il obtient directement une courbe de radioactivite sanguine d'allure exponentielle decroissante dont il definit la formule mathematique. La

  10. Radio-active colloids in the functional exploration of the reticulo-endothelium system; Les colloides radioactifs dans l'exploration fonctionnelle du systeme reticulo-endothelial

    Energy Technology Data Exchange (ETDEWEB)

    Chivot, J J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-03-01

    state of activity. The phagocytic index K depends also on the diameter of the colloidal particles injected and can be used as biological test for a colloid: this is the percentage of injected colloid which is retained by the S.R.E. per unit time. This index depends on anaesthetics, on the state of inflammation of the organism and on chemical mediators such as histamine. (author) [French] Un rappel historique met en lumiere le systeme reticulo-endothelial S.R.E. et tente d'en preciser l'identite et le fonctionnememt. Les methodes de son exploration et les colloides utilises sont envisages. L'auteur est amene a fabriquer un colloide d'un type particulier: un complexe albuminique radioiode le 'C.A. {sup 131}I' dont il decrit les etapes de la preparation et des essais tant physiques que biologiques. Une albumine humaine, presentant en solution une densite optique definie est portee a la chaleur jusqu'a modification de la densite optique, temoin d'une agregation des molecules proteiques. La proteine denaturee est iodee par {sup 131}I. Des controles d'electrophorese, d'ultracentrifugation et d'autoradiographie sont effectues. Cette preparation d'origine biologique atoxique et metabolisable sera comparee a l'or colloidal mieux defini qui servira de reference. Le C.A.{sup 131}I est injecte a la souris. Des mesures de radioactivite, des autoradiographies de coupe de l'animal entier, des detections de l'anthropogammametre mettent en evidence une concentration importante au niveau du S.R.E. du foie. Mais ces resultats statiques ont une portee limitee en regard de l'exploitation d'une etude cinetique in vivo du phenomene. L'auteur enregistre les variations de la radioactivite du sang derive de la carotide dans un scintillateur a puits. Il obtient directement une courbe de radioactivite sanguine d'allure exponentielle decroissante dont il definit la formule mathematique. La periode biologique T 1/2 du colloide dans le sang est le reflet de sa phagocytose par les cellules du S

  11. Apoplejía pituitaria con parálisis del III par craneal: Reporte de caso

    Directory of Open Access Journals (Sweden)

    Miguel Pinto Valdivia

    2011-10-01

    Full Text Available Se describe el caso de un varón de 65 años de edad, sin antecedentes patológicos de importancia, que acudió a emergencia del Hospital Nacional Cayetano Heredia por presentar cefalea intensa y ptosis palpebral izquierda. El examen físico mostró parálisis aislada del III par craneal izquierdo. Los análisis de laboratorio mostraron hiponatremia e hipopituitarismo y la resonancia magnética nuclear un adenoma pituitario con áreas de hemorragia e invasión de los senos cavernosos. El tratamiento incluyó glucocorticoides y descompresión quirúrgica transesfenoidal. La anatomía patológica confirmó el diagnóstico de infarto hemorrágico de un adenoma pituitario. El paciente fue dado de alta con terapia sustitutiva de levotiroxina y prednisona. La ptosis palpebral izquierda se recuperó en forma parcial. La apoplejía pituitaria es un síndrome clínico producido por un proceso expansivo dentro de la silla turca, secundario a hemorragia o infarto de un adenoma pituitario, que se caracteriza por cefalea, déficit visual, oftalmoplejía y alteración del nivel de conciencia. Este proceso expansivo puede comprimir los pares craneales en los senos cavernosos, produciendo diferentes grados de parálisis de los músculos oculomotores. La parálisis aislada del III par craneal es rara.(Rev Med Hered 2011;22:186-189.

  12. Épidémiologie de l'intoxication par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Introduction: L'intoxication par envenimation est l'ensemble des manifestations locales et générales induites par la pénétration dans l'organisme d'une substance toxique produite par un animal venimeux. Le but de notre travail était d'étudier les signes cliniques des intoxications par envenimation chez les enfants de 0 à 15 ...

  13. Radioactive Waste Facilities at the Australian Atomic Energy Commission Research Establishment; Installations pour le Traitement des Dechets Radioactifs au Centre de Recherche de la Commission Australienne a l'Energie Atomique; 0423 0421 0422 0414 ; Dispositivos para Evacuacion de Desechos Radiactivos en el Centro de Investigaciones de la Australian Atomic Energy Commission

    Energy Technology Data Exchange (ETDEWEB)

    Berglin, C. L.W.; Keher, L. H.; Miles, G. L.; Wilson, A. R.W. [Australian Atomic Energy Commission Research Establishment, Lucas Heights, Sydney, NSW (Australia)

    1960-07-01

    This paper describes the facilities,which are being provided for the collection, treatment and disposal of radioactive wastes at Lucas Heights in relation to the estimated arisings. Low-activity effluent is divided into three types: (a) Sewage; (b) Trades waste, arising from reactor cooling tower blow-down and engineering workshops and other inactive areas; and (c) Effluent arising from laboratories and other active areas. The effluent treatment plant for the latter type of effluent consists essentially of mixing and alkali dosing tanks, a sludge-blanket clarifier (using a calcium- iron-phosphate process) and holding tanks. Methods of concentrating the sludge and of secondary treatment are at present being investigated and are discussed. The discharge formula and the expected dilution obtained in the Woronora river are discussed, together with a dilution experiment carried out in the tidal waters. It is proposed to bury all low-activity solid waste after baling where appropriate and the choice and location of the disposal area is discussed. A facility for the storage and disposal of highly active solid waste is discussed. It is proposed to evaporate and store the medium- and high-activity liquid waste. Details are given of the capital and operating costs of the Effluent Treatment Plant and other waste handling facilities. (author) [French] Le memoire decrit les installations que le Centre de Lucas Heights cree a l'heure actuelle, eu egard au developpement envisage'en matiere de rassemblement, de traitement et d'elimination des dechets radioactifs. Les' effluents de faible activite se divisent en trois categories: a) Eaux d'egout; b) Dechets industriels provenant de la tour de refroidissement du reacteur, des ateliers et d'autres zones non-actives; c) Effluents provenant des laboratoires et d'autres zones actives. L'usine affectee au traitement du dernier type d'effluents se compose essentiellement de malaxeurs, de bacs de dosage d'alcalis, d'un clarificateur d

  14. Soluble urokinase plasminogen activator receptor (suPAR) in acute care

    DEFF Research Database (Denmark)

    Rasmussen, Line Jee Hartmann; Ladelund, Steen; Haupt, Thomas Huneck

    2016-01-01

    for age, sex, Charlson score and C reactive protein. Area under the curve for receiver operating characteristics curve analysis of suPAR for 30-day mortality was 0.84 (95% CI 0.81 to 0.86). Furthermore, in the entire cohort, women had slightly higher suPAR compared with men, and suPAR was associated...

  15. Movement and equipositioning of plasmids by ParA filament disassembly

    DEFF Research Database (Denmark)

    Ringgaard, Simon; van Zon, Jeroen; Howard, Martin

    2009-01-01

    , plasmids consistently migrate behind disassembling ParA cytoskeletal structures, suggesting that ParA filaments pull plasmids by depolymerization. The perpetual cycles of ParA assembly and disassembly result in continuous relocation of plasmids, which, on time averaging, results in equidistribution...

  16. Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy.

    Science.gov (United States)

    Rwibasira Rudinga, Gamariel; Khan, Ghulam Jilany; Kong, Yi

    2018-02-14

    Cardiovascular diseases (CVDs) are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs), including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR). Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  17. Protease-Activated Receptor 4 (PAR4: A Promising Target for Antiplatelet Therapy

    Directory of Open Access Journals (Sweden)

    Gamariel Rwibasira Rudinga

    2018-02-01

    Full Text Available Cardiovascular diseases (CVDs are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs, including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR. Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  18. Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway

    International Nuclear Information System (INIS)

    Li, Taiyuan; Liu, Dongning; Lei, Xiong; Jiang, Qunguang

    2017-01-01

    Partitioning defective 3-like protein (Par3L) is a recently identified cell polarity protein that plays an important role in mammary stem cell maintenance. Previously, we showed that high expression of Par3L is associated with poor survival in malignant colorectal cancer (CRC), but the underlying mechanism remained unknown. To this end, we established a Par3L knockout colorectal cancer cell line using the CRISPR/Cas system. Interestingly, reduced proliferation, enhanced cell death and caspase-3 activation were observed in Par3L knockout (KO) cells as compared with wildtype (WT) cells. Consistent with previous studies, we showed that Par3L interacts with a tumor suppressor protein liver kinase B1 (Lkb1). Moreover, Par3L depletion resulted in abnormal activation of Lkb1/AMPK signaling cascade. Knockdown of Lkb1 in these cells could significantly reduce AMPK activity and partially rescue cell death caused by Par3L knockdown. Furthermore, we showed that Par3L KO cells were more sensitive to chemotherapies and irradiation. Together, these results suggest that Par3L is essential for colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway, and is a putative therapeutic target for CRC. - Highlights: • Par3L knockout using the CRISPR/Cas system induces apoptosis in colorectal cancer cells. • Par3L interacts with Lkb1 and regulates the activity of AMPK signaling cascade. • Par3L knockout cells are more sensitive to treatment of different chemotherapy drugs and irradiation.

  19. Brésil : La contamination par le mercure en Amazonie | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    11 janv. 2011 ... En tentant de déceler la source de la contamination de l'Amazone par le ... par Jean-Rémy Davy Guimaraes de l'Université fédérale de Rio de Janeiro ... ces mattes est circonscrite par la conservation et la restauration en rive.

  20. Formation and de-excitation of hot nuclei in reactions induced by proton beams (475 MeV and 2 GeV) and {sup 3}He beam (2 GeV); Formation et desexcitation des noyaux chauds dans les reactions induites par des faisceaux de protons (475 MeV et 2 GeV) et d`{sup 3}He(2 GeV)

    Energy Technology Data Exchange (ETDEWEB)

    Ledoux, X.

    1995-04-01

    We are studying the formation and the de-excitation of hot nuclei created in reactions induced by light high energy projectiles. These reactions, described in a two step model: an intranuclear cascade followed by an evaporation phase, produce nuclei in which the collective modes (compression, rotation, deformation) are weakly excited. By measuring the neutron multiplicities, event by event with ORION, and the light charged particle energies and multiplicities one can evaluate the excitation energy distribution of the nuclei. At the same time, theoretical simulations are carried out using the intranuclear cascade code developed by J. Cugnon and the statistical de-excitation code GEMINI. The good agreement with experimental results indicate that 10% of the p-nucleus interactions lead to temperatures greater than 5 MeV. The observation of the fission of a nucleus with a temperature close to 5 MeV shows that the nucleus behaves as a set of bound nucleons and, that the temperature stability limit is not yet reached. The observed decline of fission probability at high excitation energies is most likely to be correlated to the appearance of an other de-excitation process (evaporation residues emission or multifragmentation) which could not be experimentally detected. Finally, in the last chapter, we briefly present the principle of transmutation for long-lived nuclear waste with a proton accelerator and underline the interest of the present work in such studies. (author). 54 refs., 80 figs., 13 tabs.

  1. Ion exchange in ultramarine blue. Studies using radioactive tracers (1963); Echanges d'ion dans le bleu d'outremer, etudies au moyen des traceurs radioactifs (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Goenvec, H [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-05-15

    A study has been made of the exchange reaction between the constituent sodium in ultramarine blue, and silver in the form of a silver nitrate solution; an attempt hat been made to define the influence of the solvent of the silver nitrate on the kinetics of the exchange reaction. Five solvents have been used: water, methanol, ethanol, n-propanol and acetone. The reaction rates are controlled by a diffusion process inside the ultramarine grains, whatever the solvent used. It seems that the solvated ionic radius of the diffusing ion is one of the factors influencing the rate of reaction. Furthermore, the solvated ionic radius varies with temperature; this variation is different for each solvent and should explain the differences observed in the activation energies. (author) [French] Nous avons etudie la reaction d'echange entre le sodium de constitution du bleu d'outremer et l'argent sous forme de nitrate d'argent en solution; nous avons essaye de definir l'influence du solvant du nitrate d'argent sur la cinetique de la reaction d'echange. Nous avons utilise cinq solvant: l'eau, le methanol, l'ethanol, le n-propanol et l'acetone. Les vitesses de reaction sont controlees par un processus de diffusion a l'interieur des grains d'outremer quel que soit le solvant. Il semble que le rayon ionique solvate de l'ion diffusant est l'un des facteurs qui influencent la vitesse de reaction. D'autre part, le rayon ionique solvate varie avec la temperature, cette variation est differente pour chaque solvant et doit pouvoir expliquer les differences d'energie d'activation constatees. (auteur)

  2. La syphilis congenitale revelee par une fracture spontanee

    Directory of Open Access Journals (Sweden)

    Mounia Lakhdar Idrissi

    2011-11-01

    Full Text Available Alors qu�elle est actuellement oubliee dans les pays developpes, la syphilis congenitale se voit encore chez nous faute du depistage antenatal. Ses formes cliniques sont polymorphes et orientent a tord vers d�autres pathologies surtout en periode neonatale. Le diagnostic n�est donc pas toujours facile. La revelation d�une syphilis congenitale par une fracture spontanee est exceptionnellement decrite. Nous rapportons dans ce travail le cas d�un nourrisson de 2 mois ramene en consultation pour limitation douloureuse des mouvements du bras droit. Le diagnostic est evoque sur les donnees radiologiques et confirme par la serologie syphilitique. Le traitement a repose essentiellement sur l�administration de la penicilline G avec une bonne evolution clinique.

  3. Results of Preliminary Tests of PAR Bunch Cleaning

    CERN Document Server

    Yao, Chihyuan; Grelick, Arthur; Lumpkin, Alex H; Sereno, Nicholas S

    2005-01-01

    A particle accumulator ring (PAR) is used at the Advanced Photon Source (APS) to collect multiple linac bunches and compress them into a 0.3-ns (rms) single bunch for booster injection. A 9.77-MHz fundamental rf system and a 117.3-MHz harmonic rf system are employed for initial beam capture and bunch length compression. Satellite bunches with very low charge form due to rf phase drifts or beam loading change. These satellites, when injected into the booster and then into the storage ring (SR), cause bunch impurity at three buckets from the target bucket. Storage ring and booster bunch cleaning was tried but proved to be difficult due to the top-up mode of operation in the storage ring and tune drift in the booster synchrotron. Recently we implemented a PAR bunch-cleaning system with tune-modulated harmonic rf knockout. Preliminary tests gave a measured SR bunch purity of better than 10

  4. Avis 6 sur la formation à et par la recherche

    OpenAIRE

    Centre de Coopération Internationale en Recherche Agronomique pour le Développement

    2015-01-01

    La formation à et par la recherche s’appuie sur la démarche scientifique, les savoirs, les connaissances à transmettre, tout autant que l’acquisition de compétences en gestion de projet, de capacités au travail en équipe, d’une ouverture d’esprit qui favorisera la créativité. Elle doit permettre de prendre conscience de la responsabilité endossée par la communauté scientifique vis-à-vis de la société et de l’environnement, mais aussi préparer l’avenir professionnel de celle ou de celui qu...

  5. Evaluation of the Stability After Orthodontic Treatment Using PAR Index

    Directory of Open Access Journals (Sweden)

    Chaitra Ramanathan

    2006-01-01

    Full Text Available The aim of the present study is to establish the results using the scores obtained from the methodology that was applied for assessing the stability after 2 years post orthodontic treatment and stability in a sample of 69 individuals. After applying PAR index to the collected group of patients, a series of scores were obtained, which were then needed to be evaluated further to establish the results. The scores were evaluated using the nomogram. A comparison was done between the post treatment and the 2 years post treatment PAR weighting scores to determine if the results were stable after orthodontic treatment. The majority of the orthodontic patients were treated to a good standard and that the results appeared to be stable.

  6. Problems Arising from Disposal of Low-Activity Radioactive Waste in the Coastal Waters of the Netherlands; Problemes Poses par l'Evacuation des dechets de Faible Radioactivite dans les Eaux Cotieres des Pays-Bas; 041f 0420 041e 0414 ; Problemas que Plantea la Evacuacion de Desechos Radiactivos de Baja Actividad en las Aguas Costeras de los Paises Bajos

    Energy Technology Data Exchange (ETDEWEB)

    Korringa, P. [Netherlands Institute for Fishery Investigations, Ijmuiden (Netherlands)

    1960-07-01

    Low-activity waste discharged in coastal waters will find its way into the marine food chain in two entirely different ways: 1. Adsorption to the surface of plankton organisms and adsorption to silt particles. In the latter case, fish and other creatures may ingest the loaded particles with their regular food. If the elements under consideration are not of primary biological importance to the organisms concerned, accumulation will not increase geometrically. Much of the radioactive material attached to ingested silt particles will leave the organisms later. 2. Accumulation through active uptake of elements collected in dissolved state by shell-bearing organisms. Copper, zinc, manganese, cobalt and the like are accumulated very strongly by shell-forming creatures like molluscs, and are stored in the connective tissues. If a part worth mentioning of these elements is of a radioactive nature, accumulation could attain alarming levels. Shrimps, Dover soles, plaice, and mussels being the main fishery products in the vicinity of the pipeline planned for the Netherlands centre for reactor research, noticeable accumulation of radioactive waste in these organisms should be prevented. The special international position of the Netherlands fish market requires extra care, and migration of fishes and shrimps makes it impossible to avoid a contaminated area. (author) [French] Les dechets de faible radioactivite evacues dans les eaux cotieres atteindront le milieu biologique marin par deux voies totalement distinctes: 1. Adsorption par le plancton et adsorption par les particules sedimentaires. Dans ce dernier cas, les poissons et autres animaux peuvent ingerer les particules chargees avec leur nourriture habituelle. Si les elements en question ne presentent pas pour ces organismes une grande importance biologique, la quantite accumulee ne croitra pas dans une proportion geometrique. Une grande partie des produits radioactifs fixes sur les particules sedimentaires ingerees sera

  7. La parálisis cerebral en el contexto escolar /

    OpenAIRE

    González Vara, Azucena

    2012-01-01

    Se analiza el concepto de parálisis cerebral, los diferentes tipos y sus características. También las adaptaciones que se deben realizar a nivel de centro, de aula, y a nivel individual para estos alumnos, conocer los diferentes sistemas alternativos y aumentativos de comunicación y aplicar las ayudas técnicas que precisa este alumnado

  8. Tuberculose lymphonodale cervicale chez les enfants vaccines par ...

    African Journals Online (AJOL)

    La tuberculose ganglionnaire cervicale est une localisation extrapulmonaire relativement fréquente chez l'enfant. Elle pose essentiellement des difficultés de prévention. L'objectif de ce travail est d'étudier les particularités diagnostiques et thérapeutiques chez des enfants vaccinés par le BCG. Matériel et méthodes: Nôtre ...

  9. Traitement De La Peripneumonie Contagieuse Bovine Par L ...

    African Journals Online (AJOL)

    Traitement De La Peripneumonie Contagieuse Bovine Par L'oxyteTracycline Longe Action Et Transmission Experimentale de la Maladie A Partir de Bovins Traites. ... Tous les 14 animaux ont séroconverti et l'analyse post-mortem a montré la présence des lésions chroniques dont des séquestres pulmonaires chez 4 d'entre ...

  10. Adoption d'innovations agricoles par le truchement de services ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'agriculture est le fer de lance de nombreuses économies en développement, mais la capacité des petits agriculteurs privés de ressources à adopter des innovations agricoles est freinée par le manque d'accès à des services financiers adéquats. Des experts internationaux estiment qu'il existe un manque à gagner ...

  11. Candido: Uma Leitura Paródica de Candide

    Directory of Open Access Journals (Sweden)

    Maria Gloria Cusumano Mazzi

    2010-12-01

    Full Text Available O presente artigo estuda a leitura paródica que Leonardo Sciascia (1921-1989 faz de Voltaire (1694-1778 mediante o cotejo das obras: o hipertexto Candido ovvero Un sogno fatto in Sicilia (1977 e o hipotexto Candide ou l’optimisme (1759. Apresenta ainda outra possibilidade de leitura, ou seja, Candido como metáfora da própria intertextualidade.

  12. Solution volumes finis polynomiale par morceaux pour les ...

    African Journals Online (AJOL)

    Nous présentons dans ce papier un concept de solution volumes finis continue pour des problèmes de diffusion-convection avec des données régulières. Nous comparons dans certains cas particuliers la solution proposée avec la solution volumes finis classiques (qui est une fonction constante par morceaux) et la ...

  13. Preliminary Analysis For Wolsong Par Effects Using ISACC Calculations

    International Nuclear Information System (INIS)

    Song, Yong Mann; Kim, Dong Ha

    2012-01-01

    In the paper, hydrogen control effects using PARs only are analyzed for severe SBO station blackout (SBO) sequences beyond the design basis accidents in WS-1 which are of CANDU6 type reactor. As a computational tool, the latest version of ISAAC4.3 (Integrated Severe Accident Analysis Code for CANDU), which is a fully integrated and lumped severe accident computer code, is used to simulate hydrogen generation and transport inside the reactor building (R/B) before its failure. For the performance of hydrogen removal, the depletion rate equation of K-PAR developed in Korea is applied. In a CANDU reactor, three areas are identified as sources of hydrogen under severe accidents: fuel-coolant interactions in intact channels, suspended fuel or debris interactions in-calandria tank and debris interactions in-calandria vault. The first two origins provide source for the late ('late' terminology is used because it takes more than one day before calandria tank failure) potential hydrogen combustion before calandria tank failure and all the three origins would provide source for the very late potential hydrogen combustion occurring at or after calaria tank failure. If the hydrogen mitigation system fails, the AICC (adiabatic isochoric complete combustion) burning of highly flammable hydrogen may cause Wolsong R/B failure. So hydrogen induced failure possibility is evaluated, using preliminary ISAAC calculations, under several SBO conditions with and without PAR for both late and very late accident periods

  14. Protease activated receptors (PARS) mediation in gyroxin biological activity

    International Nuclear Information System (INIS)

    Silva, Jose Alberto Alves da

    2009-01-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH 2 , respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  15. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob

    2012-01-01

    the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture...... of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles....

  16. First (18)F-labeled ligand for PET imaging of uPAR

    DEFF Research Database (Denmark)

    Persson, Morten; Liu, Hongguang; Madsen, Jacob

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA......-conjugated version (NOTA-AE105) for development of the first (18)F-labeled uPAR positron-emission-tomography PET ligand using the Al(18)F radiolabeling method. In this study, the potential of (18)F-AlF-NOTA-AE105 to specifically target uPAR-positive prostate tumors was investigated....

  17. Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

    DEFF Research Database (Denmark)

    Rasch, M.G.; Lund, I.K.; Hoyer-Hansen, G.

    2008-01-01

    identified in tissue and body fluids. It is well-established, that the total amount of all uPAR forms is a strong prognostic marker in different types of cancer. Using immunoassays, measuring the individual uPAR forms, has revealed that the cleaved uPAR forms are even stronger prognostic markers and have...... diagnostic utility. This review will focus on the mechanism of uPAR cleavage and the functional consequences, as well as the clinical applicability of cleaved uPAR forms Udgivelsesdato: 2008...

  18. Dynamic Filament Formation by a Divergent Bacterial Actin-Like ParM Protein.

    Directory of Open Access Journals (Sweden)

    Anthony J Brzoska

    Full Text Available Actin-like proteins (Alps are a diverse family of proteins whose genes are abundant in the chromosomes and mobile genetic elements of many bacteria. The low-copy-number staphylococcal multiresistance plasmid pSK41 encodes ParM, an Alp involved in efficient plasmid partitioning. pSK41 ParM has previously been shown to form filaments in vitro that are structurally dissimilar to those formed by other bacterial Alps. The mechanistic implications of these differences are not known. In order to gain insights into the properties and behavior of the pSK41 ParM Alp in vivo, we reconstituted the parMRC system in the ectopic rod-shaped host, E. coli, which is larger and more genetically amenable than the native host, Staphylococcus aureus. Fluorescence microscopy showed a functional fusion protein, ParM-YFP, formed straight filaments in vivo when expressed in isolation. Strikingly, however, in the presence of ParR and parC, ParM-YFP adopted a dramatically different structure, instead forming axial curved filaments. Time-lapse imaging and selective photobleaching experiments revealed that, in the presence of all components of the parMRC system, ParM-YFP filaments were dynamic in nature. Finally, molecular dissection of the parMRC operon revealed that all components of the system are essential for the generation of dynamic filaments.

  19. Proteinase-Activated Receptor 1 (PAR1 regulates leukemic stem cell functions.

    Directory of Open Access Journals (Sweden)

    Nicole Bäumer

    Full Text Available External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  20. Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.

    Science.gov (United States)

    Bäumer, Nicole; Krause, Annika; Köhler, Gabriele; Lettermann, Stephanie; Evers, Georg; Hascher, Antje; Bäumer, Sebastian; Berdel, Wolfgang E; Müller-Tidow, Carsten; Tickenbrock, Lara

    2014-01-01

    External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  1. Processing and Pre-Treatment of Solid Radioactive Waste; Conditionnement des Dechets Radioactifs Solides; 041e 0411 0420 0414 ; Acondicionamiento de los Desechos Radiactivos Solidos

    Energy Technology Data Exchange (ETDEWEB)

    Cerre, P. [Service de Controle des Radiations et de Genie Radioactif, Commissariat a l' Energie Atomique, Saclay (France)

    1960-07-01

    As solid radioactive waste varies in form, dimensions and volume, the Atomic Energy Commission first of all reduces the volume by breaking up and compressing the waste. Since the temporary storage of such waste is always attended by the risk of contamination, an efficient packing system has been devised and adopted. This consists of embedding the waste in the heart of a specially-designed block of concrete possessing the following characteristics: Great strength Maximum insolubility Resistance to corrosion Maximum imperviousness Protection against radiation. It is thus quite safe to store these blocks with a view to final dumping. (author) [French] Les dechets actifs solides etant de formes, de dimensions et de volumes varies, le C.E.A. procede en premier lieu a une reduction de volume par fractionnement et compactage. L'emmagasinage provisoire de tels dechets ne pouvant se concevoir sans risques de contamination, un procede efficace d'emballage a ete etudie et realise. Il consiste a noyer les dechets dans un beton specialement etudie qui presente les caracteristiques suivantes: - Forte resistance mecanique . - Insolubilite maximum - Resistance a la corrosion - Etancheite maximum - Protection contre le rayonnement Il est alors possible de conserver sans danger les blocs formes en vue d'un rejet definitif ulterieur. (author) [Spanish] Como los desechos radiactivos solidos difieren mucho por su forma, dimension y volumen, el Commissariat efectua en primer lugar una reduccion de volumen desmenuzandolos y comprimiendolos. El almacenamiento provisional de esos desechos presenta siempre riesgos de contaminacion, por lo que se ha estudiado y llevado a la practica un sistema especial de embalaje. Este sistema consiste en empotrar los desechos en un hormigon especialmente estudiado que ofrece las siguientes caracteristicas: - Fuerte resistencia mecanica - Maximum de insolubilidad - Resistencia a la corrosion - Maximum de estanquidad - Proteccion contra las radiaciones De

  2. The Depths of the Ocean and the Question of Radioactive Waste Disposal in Them; Les Grandes Fosses Oceaniques et l'Immersion des Dechets Radioactifs dans ces Eaux Profondes; 0413 041b 0423 0414 ; Cuestiones Relacionadas con la Inmersion de Desechos Radiactivos en las Grandes Fosas

    Energy Technology Data Exchange (ETDEWEB)

    Bogorov, V. G.; Tareev, B. A.; Fedorov, K. N. [Oceanographical Institute of the Academy of Sciences of the USSR, Moscow, USSR (Russian Federation)

    1960-07-01

    . Aucune d'elles ne possede de particularites morphologiques pouvant empecher les eaux profondes d'y penetrer ou de s'ecouler. L'augmentation progressive de la temperature de l'eau a partir de 3.000 a 5.000 metres de profondeur jusqu'au fond de ces fosses provoque des courants verticaux de convexion dans les eaux profondes. Il est theoriquement prouve que malgre l'effet stabilisateur du mouvement de rotation de la terre, il doit exister des courants de convexion alveolaires, meme lorsque les differences de temperature superadiabatiques restent tres petites. La repartition verticale de la teneur en oxygene en fonction de l'augmentation caracteristique du taux de saturation et de concentration en O{sub 2}, qui va en s'accentuant depuis la couche minimum (1.000 metres) jusqu'au fond, permet de presumer l'existence d'un mouvement horizontal et vertical ou bien d'un deplacement horizontal des eaux profondes dans toute leur masse. S'il n'en etait pas ainsi, l'utilisation biochimique de l'oxygene (au moins 0,1 ml par an) entrainerait un epuisement total des reserves de cet element dans les eaux profondes en un laps de temps relativement court (40 a 60 ans). L'existence de courants horizontaux assez rapides (5 a 17 cm/s) a des profondeurs de 1.000 a 3.000 metres a ete demontree par les mesures directes qui ont ete effectuees dans l'Atlantique et le Pacifique. La diffusion des particules dissoutes ou suspendues dans la mer n'est pas uniquement due a la circulation des eaux, au sens physique de ce terme. Le deplacement continu des organismes vivants constitue, en effet, un risque supplementaire de voir les substances radioactives accumulees dans les tissus de ces organismes etre diffusees par ceux-ci ou transmises par les chaines alimentaires a des distances considerables et a une grande vitesse, comme on a pu le constater apres les explosions experimentales qui ont eu lieu dans l'Ocean Pacifique. Il faut donc admettre qu'il est impossible d'immerger des dechets radioactifs dans les

  3. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...

  4. The application of radioactive isotopes to the study of motion of silt and pebbles in the rivers and in the sea; Application des isotopes radioactifs a l'etude des mouvements des sediments et des galets dans les cours d'eau et en mer

    Energy Technology Data Exchange (ETDEWEB)

    Hours, R [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Jaffry, P [Electricite de France (EDF), 78 - Chatou (France). Lab. National d' Hydraulique

    1959-07-01

    The application of radioactive tracers to the study of sediments drift has received considerable attention since 1954 in various countries. A comparative review is made of a number of techniques of labelling, immersing and detecting silts, sands, and pebbles. The influence of the burying of the active material is emphasized. The different experiments which have been so far carried out are described. (author) [French] L'application des traceurs radioactifs a l'etude des deplacements de sediments a fait depuis 1954 l'objet de travaux nombreux dans divers pays. On passe en revue et on compare differentes techniques de marquage, d'immersion et de detection des vases, sables et galets; on insiste sur l'influence de l'enfouissement du materiau actif. On decrit les differentes experiences effectuees jusqu'a ce jour. (auteur)

  5. Circulations in the Bay of Bengal and the Arabian Sea with Reference to Safe Disposal of Radioactive Wastes Near the Indian Coasts; Les Circulations dans les Eaux du Golfe du Bengale et de la Mer d'Oman et l'Elimination sans Danger des Dechets Radioactifs pres des Cotes Indiennes; 0426 0418 0420 0414 ; Circulaciones en el Golfo de Bengala e en el Mar Arabico con Relacion a la Evacuacion sin Riesgos de Desechos Radiactivos Frente al Litoral Indio

    Energy Technology Data Exchange (ETDEWEB)

    Rama Sastry, A. A. [Meteorological Office, Poona 5 (India)

    1960-07-01

    admixture of the Indian Central water, Indian deep water and the Antarctic bottom water. The distribution of these water masses and the deep water circulation north of the equator are given. During the past 60 years, the Antarctic bottom water seems to be advancing further north of the equator both into the Bay of Bengal and the Arabian Sea. Consequently, lowering of salinity is recorded both in the Bay and the Arabian Sea. Finally, a programme of further oceanographic work in connexion with the safe disposal of radioactive wastes, particularly into the Arabian Sea, is suggested. (author) [French] L'auteur passe rapidement en revue les connaissances generales acquises sur l'oceanographie du golfe du Bengale et de la mer d'Oman. Sur la base des etudes effectuees depuis quelques annees par les nombreuses stations oceanographiques qui fonctionnent Je long des cotes indiennes, l'auteur etudie les conditions oceanographiques du point de vue de l'elimination sans danger des dechets radioactifs. Il s'est egalement servi des donnees reunies par differentes expeditions dans l'ocean Indien pour etudier l'oceanographie physique de la region situee au nord de l'Equateur. Jusqu'a 200 m au-dessous de la surface, les masses d'eau du golfe du Bengale et de la mer d'Oman se repartissent en trois categories au moins. Dans le golfe du Bengale, etant donne le taux de dilution tres eleve, les eaux de surface pourraient etre divisees en un plus grand nombre de categories. Compte tenu de la valeur de differents parametres oceanographiques sur divers plans horizontaux, ou a calcule la circulation le long des cotes indiennes a plusieurs niveaux jusqu'a 150 m de profondeur; a partir de sections verticales, on a deduit la circulation jusqu'a une profondeur de 500 m. La profondeur a laquelle il n'y a pas de mouvements parait bien inferieure a 500 m; elle varie dans l'espace et dans le temps. Le taux de melange des eaux est calcule a partir des rapports espace-temps. L'auteur indique les saisons au

  6. ParABS Systems of the Four Replicons of Burkholderia cenocepacia: New Chromosome Centromeres Confer Partition Specificity†

    Science.gov (United States)

    Dubarry, Nelly; Pasta, Franck; Lane, David

    2006-01-01

    Most bacterial chromosomes carry an analogue of the parABS systems that govern plasmid partition, but their role in chromosome partition is ambiguous. parABS systems might be particularly important for orderly segregation of multipartite genomes, where their role may thus be easier to evaluate. We have characterized parABS systems in Burkholderia cenocepacia, whose genome comprises three chromosomes and one low-copy-number plasmid. A single parAB locus and a set of ParB-binding (parS) centromere sites are located near the origin of each replicon. ParA and ParB of the longest chromosome are phylogenetically similar to analogues in other multichromosome and monochromosome bacteria but are distinct from those of smaller chromosomes. The latter form subgroups that correspond to the taxa of their hosts, indicating evolution from plasmids. The parS sites on the smaller chromosomes and the plasmid are similar to the “universal” parS of the main chromosome but with a sequence specific to their replicon. In an Escherichia coli plasmid stabilization test, each parAB exhibits partition activity only with the parS of its own replicon. Hence, parABS function is based on the independent partition of individual chromosomes rather than on a single communal system or network of interacting systems. Stabilization by the smaller chromosome and plasmid systems was enhanced by mutation of parS sites and a promoter internal to their parAB operons, suggesting autoregulatory mechanisms. The small chromosome ParBs were found to silence transcription, a property relevant to autoregulation. PMID:16452432

  7. Serum suPAR in patients with FSGS: trash or treasure?

    Science.gov (United States)

    Maas, Rutger J H; Deegens, Jeroen K J; Wetzels, Jack F M

    2013-07-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both overexpression of uPAR on podocytes and the administration of suPAR cause proteinuria in mice. The common pathogenic mechanism involves the activation of podocyte β3-integrin. Increased activation of β3-integrin is also observed in patients with focal and segmental glomerulosclerosis (FSGS). These observations form the basis for the hypothesis that suPAR may be the circulating factor causing FSGS. A recent study fosters this idea by demonstrating increased suPAR levels in the serum of patients with FSGS and reporting an association with recurrence after transplantation and response to plasmapheresis. However, this study was heavily biased, and subsequent studies have given conflicting results. Although the experimental work is very suggestive, at present there is no proof that any known human suPAR fragment causes FSGS in humans. We therefore suggest that the measurement of suPAR using currently available assays has absolutely no value at the present time in decision-making in routine clinical practice.

  8. PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity

    Directory of Open Access Journals (Sweden)

    Henrique FUKUSHIMA

    Full Text Available Abstract Recent studies investigating protease-activated receptor type 2 (PAR-2 suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF of patients with moderate chronic periodontitis (MP. The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19 at baseline, and from MP patients (n = 19 and severe chronic periodontitis (SP (n = 19 patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR. PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p <0.05 PAR-2 expression in patients with periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.

  9. Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.

    Science.gov (United States)

    Bharat, Tanmay A M; Murshudov, Garib N; Sachse, Carsten; Löwe, Jan

    2015-07-02

    Active segregation of Escherichia coli low-copy-number plasmid R1 involves formation of a bipolar spindle made of left-handed double-helical actin-like ParM filaments. ParR links the filaments with centromeric parC plasmid DNA, while facilitating the addition of subunits to ParM filaments. Growing ParMRC spindles push sister plasmids to the cell poles. Here, using modern electron cryomicroscopy methods, we investigate the structures and arrangements of ParM filaments in vitro and in cells, revealing at near-atomic resolution how subunits and filaments come together to produce the simplest known mitotic machinery. To understand the mechanism of dynamic instability, we determine structures of ParM filaments in different nucleotide states. The structure of filaments bound to the ATP analogue AMPPNP is determined at 4.3 Å resolution and refined. The ParM filament structure shows strong longitudinal interfaces and weaker lateral interactions. Also using electron cryomicroscopy, we reconstruct ParM doublets forming antiparallel spindles. Finally, with whole-cell electron cryotomography, we show that doublets are abundant in bacterial cells containing low-copy-number plasmids with the ParMRC locus, leading to an asynchronous model of R1 plasmid segregation.

  10. PAR-1 contributes to the innate immune response during viral infection

    Science.gov (United States)

    Antoniak, Silvio; Owens, A. Phillip; Baunacke, Martin; Williams, Julie C.; Lee, Rebecca D.; Weithäuser, Alice; Sheridan, Patricia A.; Malz, Ronny; Luyendyk, James P.; Esserman, Denise A.; Trejo, JoAnn; Kirchhofer, Daniel; Blaxall, Burns C.; Pawlinski, Rafal; Beck, Melinda A.; Rauch, Ursula; Mackman, Nigel

    2013-01-01

    Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed the role of PAR-1 in coxsackievirus B3–induced (CVB3-induced) myocarditis and influenza A infection. CVB3-infected Par1–/– mice expressed reduced levels of IFN-β and CXCL10 during the early phase of infection compared with Par1+/+ mice that resulted in higher viral loads and cardiac injury at day 8 after infection. Inhibition of either tissue factor or thrombin in WT mice also significantly increased CVB3 levels in the heart and cardiac injury compared with controls. BM transplantation experiments demonstrated that PAR-1 in nonhematopoietic cells protected mice from CVB3 infection. Transgenic mice overexpressing PAR-1 in cardiomyocytes had reduced CVB3-induced myocarditis. We found that cooperative signaling between PAR-1 and TLR3 in mouse cardiac fibroblasts enhanced activation of p38 and induction of IFN-β and CXCL10 expression. Par1–/– mice also had decreased CXCL10 expression and increased viral levels in the lung after influenza A infection compared with Par1+/+ mice. Our results indicate that the tissue factor/thrombin/PAR-1 pathway enhances IFN-β expression and contributes to the innate immune response during single-stranded RNA viral infection. PMID:23391721

  11. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

    International Nuclear Information System (INIS)

    Boosen, Meike; Vetterkind, Susanne; Koplin, Ansgar; Illenberger, Susanne; Preuss, Ute

    2005-01-01

    Par-4 (prostate apoptosis response-4) sensitizes cells to apoptotic stimuli, but the exact mechanisms are still poorly understood. Using Par-4 as bait in a yeast two-hybrid screen, we identified Amida as a novel interaction partner, a ubiquitously expressed protein which has been suggested to be involved in apoptotic processes. Complex formation of Par-4 and Amida occurs in vitro and in vivo and is mediated via the C-termini of both proteins, involving the leucine zipper of Par-4. Amida resides mainly in the nucleus but displays nucleo-cytoplasmic shuttling in heterokaryons. Upon coexpression with Par-4 in REF52.2 cells, Amida translocates to the cytoplasm and is recruited to actin filaments by Par-4, resulting in enhanced induction of apoptosis. The synergistic effect of Amida/Par-4 complexes on the induction of apoptosis is abrogated when either Amida/Par-4 complex formation or association of these complexes with the actin cytoskeleton is impaired, indicating that the Par-4-mediated relocation of Amida to the actin cytoskeleton is crucial for the pro-apoptotic function of Par-4/Amida complexes in REF52.2 cells. The latter results in enhanced phosphorylation of the regulatory light chain of myosin II (MLC) as has previously been shown for Par-4-mediated recruitment of DAP-like kinase (Dlk), suggesting that the recruitment of nuclear proteins involved in the regulation of apoptotic processes to the actin filament system by Par-4 represents a potent mechanism how Par-4 can trigger apoptosis

  12. Bacterial mitosis: Partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    DEFF Research Database (Denmark)

    Ebersbach, G.; Gerdes, Kenn

    2004-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells......A-GFP oscillated in spiral-shaped structures. Amino acid substitutions in ParA simultaneously abolished ParA spiral formation, oscillation and either plasmid localization or plasmid separation at mid-cell. Therefore, our results suggest that ParA spirals position plasmids at the middle of the bacterial nucleoid...

  13. Comprehensive measurements in 4 {pi} geometry for radio-active samples having a low {beta}-activity (1962); Ensemble de mesure'en geometrie 4 {pi} pour echantillons radioactifs de faible activite {beta} (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Colomer, J; Valentin, M [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    The realisation is described of a comprehensive measurement system having low background noise and, as well as a lead-wall protection, an electronic protection made up of a plastic scintillator placed in anticoincidence with the 4 {pi} counter used for making the measurements. The apparatus is described and its performance discussed. (authors) [French] Realisation d'un ensemble de mesures ayant un faible bruit de fond en utilisant en plus d'une protection par murs de Pb, une protection electronique constituee par un scintillateur plastique mis en ainticoincidence avec le compteur 4 {pi} utilise pour faire les mesures. L'appareillage est decrit et ses performances discutees. (auteurs)

  14. Envenimation mortelle par morsure de serpent chez une femme ...

    African Journals Online (AJOL)

    Les auteurs rapportent un cas de morsure de serpent au niveau de la face chez une femme enceinte, dont l'évolution a été marquée par l'installation d'un oedème cervico-facial nécessitant une trachéotomie en urgence, et une mort foetale in utero avec troubles de l'hémostase responsable du décès maternel dans un ...

  15. Analysis of clinical features and visual outcomes of pars planitis.

    Science.gov (United States)

    Berker, Nilufer; Sen, Emine; Elgin, Ufuk; Atilgan, Cemile Ucgul; Dursun, Erdem; Yilmazbas, Pelin

    2018-04-01

    To evaluate the demographic characteristics, clinical features, treatment and outcomes of patients with pars planitis in a tertiary referral center in Turkey. Medical records of patients with pars planitis were retrospectively reviewed. The data including demographic and ocular features and treatment outcomes were recorded. The distribution of clinical findings and complications were evaluated according to age and gender groups. The changes in final BCVA compared to the initial BCVA were noted. Statistical analysis was performed using SPSS software (Version 18.0, SPSS Inc., Chicago, USA). Twenty-seven patients (54 eyes) were included in this study. 16 patients were male (59.3%), and 11 were female (40.7%). Mean age at diagnosis was 12.84 ± 8.26 (range 4-36) years. Mean follow-up period was 61.3 ± 52.15 (range 9-172) months. Mean BCVA was 0.58 ± 0.36 (range 0.03-1.00) (0.40 ± 0.45 logMAR) at presentation, and 0.81 ± 0.28 (range 0.10-1.00) (0.14 ± 0.27 logMAR) at final visit (P = 0.001). Vitreous inflammation (100%), vitreous haze (92.6%), snowballs (74.1%), snowbanks (66.7%), anterior chamber cells (66.7%) and peripheral retinal vascular sheathing (48.1%) were the most common presentations. Ocular complications included vitreous condensation (51.9%), cystoid macular edema (22.2%), cataract (18.5%), inferior peripheral retinal detachment (11.1%), glaucoma (5.6%) and vitreous hemorrhage (3.7%). Treatments included topical, periocular, intravitreal and systemic corticosteroids, immunosuppressives, peripheral laser photocoagulation and pars plana vitrectomy when needed. Pars planitis is an idiopathic chronic intermediate uveitis mostly affecting children and adolescents. In spite of its chronic nature with high potential of causing ocular complications, adequate treatment and close follow-up lead to favorable visual outcomes.

  16. Cartographie par carroyage et précision spatiale

    Directory of Open Access Journals (Sweden)

    Patrice LANGLOIS

    1998-03-01

    Full Text Available Dans le cadre d'une cartographie par carroyage, on étudie la désagrégation de variables zonales, en revenant sur l'hypothèse de l'équirépartition spatiale des populations. L'objectif est d'approcher des règles différenciées de désagrégation des variables en fusionnant des plans d'information de nature morphologique, topologique et environnementale.

  17. PET imaging of urokinase-type plasminogen activator receptor (uPAR) in prostate cancer

    DEFF Research Database (Denmark)

    Skovgaard, Dorthe; Persson, Morten; Kjaer, Andreas

    2016-01-01

    Overexpression of urokinase-type plasminogen activator receptors (uPAR) represents an important biomarker for aggressiveness in most common malignant diseases, including prostate cancer (PC). Accordingly, uPAR expression either assessed directly in malignant PC tissue or assessed directly in plasma...... and prognostic imaging method. In this review, we will focus on the recent development of uPAR PET and the relevance within prostate cancer imaging. Novel antibody and small-molecule radiotracers-targeting uPAR, including a series of uPAR-targeting PET ligands, based on the high affinity peptide ligand AE105......, have been synthesized and tested in vitro and in vivo in preclinical murine xenograft models and, recently, in a first-ever clinical uPAR PET study in cancer patients, including patients with PC. In this phase I study, a high and specific uptake of the tracer 64Cu-DOTA-AE105 was found in both primary...

  18. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Directory of Open Access Journals (Sweden)

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  19. Four cases of endophthalmitis after 25-gauge pars plana vitrectomy

    Directory of Open Access Journals (Sweden)

    Mutoh T

    2012-08-01

    Full Text Available Tetsuya Mutoh, Koji Kadoya, Makoto ChikudaDepartment of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, JapanAbstract: We report our recent experience with four cases of endophthalmitis (one male, three females after 25-gauge pars plana vitrectomy (PPV. One was a case of persistent cystoid macular edema caused by branch retinal vein occlusion, whereas the remaining three were cases of epiretinal membrane. Preoperative antibiotics before the first PPV procedure were not administered in three of the four cases. Endophthalmitis occurred 2–4 days after the first procedure in all cases, for which ceftazidime 2.0 mg/0.1 mL and vancomycin 1.0 mg/0.1 mL were injected into the vitreous cavity. This was followed by emergent 20-gauge PPV and intraocular lens removal using an infusion fluid containing ceftazidime and vancomycin. After the second PPV procedure, progress was good in three cases while retinal detachment occurred in the remaining case one month after surgery; this case required a third PPV procedure. Final best-corrected visual acuity ranged from 20/100 to 20/25 for the four cases. Bacterial cultures were negative after the second PPV procedure in all cases. In conclusion, postoperative endophthalmitis occurred in four of 502 cases (0.80% that underwent 25-gauge PPV at our hospital. It is important to minimize the incidence of endophthalmitis after 25-gauge PPV.Keywords: 25-gauge pars plana vitrectomy, endophthalmitis, incidence

  20. Stress reactions involving the pars interarticularis in young athletes

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated.

  1. Stress reactions involving the pars interarticularis in young athletes

    International Nuclear Information System (INIS)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    1981-01-01

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated

  2. Réduction du risque d'infection par le VIH au Botswana - essais ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au Botswana, ce sont les jeunes femmes qui sont le plus touchées par les nouvelles infections par le VIH. Le présent projet a pour but de réduire le nombre de nouveaux cas d'infection par le VIH, en particulier chez les femmes de 15 à 29 ans. Bien que l'on recense des cas de VIH/sida dans la plupart des régions du ...

  3. PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.

    Science.gov (United States)

    Fukushima, Henrique; Alves, Vanessa Tubero Euzebio; Carvalho, Verônica Franco de; Ambrósio, Lucas Macedo Batitucci; Eichler, Rosangela Aparecida Dos Santos; Carvalho, Maria Helena Catelli de; Saraiva, Luciana; Holzhausen, Marinella

    2017-01-26

    Recent studies investigating protease-activated receptor type 2 (PAR-2) suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF) of patients with moderate chronic periodontitis (MP). The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19) at baseline, and from MP patients (n = 19) and severe chronic periodontitis (SP) (n = 19) patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA) in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR). PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.

  4. Environmental Implications of Radioactive Waste Disposal as Related to Stream Environments; Incidences du Milieu sur l'Elimination des Dechets Radioactifs dans le Voisinage des Cours d'Eau; 0412 041b 0418 042f 0414 ; Efectos de la Evacuacion de Desechos Radiactivos en las Corrientes Fluviales

    Energy Technology Data Exchange (ETDEWEB)

    Straub, Conrad P.; Goldin, Abraham S.; Friend, Albert G.; Taft, Robert A. [Sanitary Engineering Center, US Department of Health, Education and Welfare, Cincinnati, OH (United States)

    1960-07-01

    Increasing volumes of radioactive waste materials are being introduced into streams annually. These originate from the many laboratories in which radioactive materials are used for beneficial purposes, as well as from existing atomic energy facilities. To these amounts introduced directly into the river under essentially controlled conditions must be added those radioactive materials originating from fall-out and feeding into the stream through run-off or direct deposition. Since these same streams may serve a multiplicity of purposes, as for example, potable and industrial water, recreation, fishing, irrigation, and navigation, the effect of these discharges on each of these activities must be carefully evaluated. Present criteria do not provide a complete basis for determining permissible levels of discharge unless information is available on the amounts of specific radionuclides already present and the fate of these same nuclides in the downstream environment. Permissible levels of discharge will have to be modified in accordance with the above information and particularly in terms of the uses to which the downstream watercourse is put. Where several sources of discharge are to be permitted on a given water-course, allocation of maximum amounts of specific radionuclides must be established in accordance with downstream exposures of populations from all sources. Several suggested approaches to the handling-of this problem of waste management in relation to downstream uses are outlined and some of the difficulties associated with the application of each approach are considered. (author) [French] Chaque annee, des quantites croissantes de dechets radioactifs sont deversees dans les cours d'eau. Ces dechets proviennent des nombreux laboratoires utilisant des substances radioactives a des fins benefiques, ainsi que des installations d'energie atomique. Aux quantites qu'on deverse directement dans les cours d'eau en se conformant aux conditions qui constituent l

  5. African Journal of Neurological Sciences - 2009 Vol. 28 No 1

    African Journals Online (AJOL)

    lavage à l'eau courante, les encéphales étaient ensuite congelés à 15° durant 3 ... cette préparation, la substance grise devenait spongieuse et les faisceaux de ... fait que la direction des molécules traduit l'orientation des tractus Par définition.

  6. Summary of Current Geological Research in the United States of America Pertinent to Radioactive Waste Disposal on Land; Bilan des Recherches Geologiques Actuelles aux Etats-Unis, du Point de Vue de l'Elimination des Dechets Radioactifs dans le Sol; 041a 0420 0414 ; Resena de las Investigaciones Geologicas que Actualmente se Efectuan en los Estados Unidos Sobre la Evacuacion de Desechos Radiactivos en el Subsuelo

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, E. S. [Geologist, US Geological Survey, Washington, DC (United States)

    1960-07-01

    'isolement qui doit etre assure aux dechets pour respecter les normes de sante et de securite generalement admises. I. Les structures assurant un isolement maximum doivent retenir pendant des siecles ou des millenaires pratiquement tous les dechets qui y sont deposes. Les recherches portent sur deux types generaux: les depots salins et les formations permeables profondes. Dans les deux cas, on procede a des experiences en laboratoire pour etudier l'interaction des dechets en solution et des matieres constituant le terrain considere; pour les depots salins, une experience sur le terrain est en cours, dans laquelle on utilise des dechets simules de. haute activite, qui, en realite, ne sont pas radioactifs. II. Les structures assurant un isolement moyen doivent ralentir notablement la mobilite des dechets pour que ceux-ci aient le temps de se desintegrer au point de vue radioactif avant de venir en contact avec l'homme ou la chaine alimentaire. Comme exemple d'isolement moyen, on peut citer l'enfouissement a faible profondeur de dechets emballes et le deversement de dechets liquides en vrac dans des couloirs d'infiltration. Des recherches sont en cours pour etudier la maniere dont se combinent le transport des radionuclides par les eaux souterraines et la retention des radionuclides fixes par sorption dans les matieres constituant le terrain. III. Les structures n'assurant aucun isolement sont celles ou les radionuclides viennent directement en contact avec l'homme ou l'un des elements vivants de la chaine alimentaire. Des recherches sont en cours a la fois pour determiner la capacite de differentes structures a recevoir de tels dechets sans que la sante et la securite en soient affectees et pour ameliorer les techniques employees a cette fin. Les recherches actuelles portent sur les points suivants : a) Classification des terrains eu egard aux problemes d'elimination des dechets; b) Etude des caracteristiques de diffusion des courants; c) Action sur la concentration de la

  7. Un « gouvernement des journalistes par le Pouvoir politique » par défaut ?

    Directory of Open Access Journals (Sweden)

    Matthieu Lardeau

    2013-12-01

    Full Text Available Cet article présente les interactions de deux mouvements concomitants apparusprincipalement dans les décennies 1950 à 1970 dans le champ de la presse française : d’un côté les initiatives – consécutives à la démarche pionnière, en 1951, de création de la première Société des journalistes (SDJ au sein du Monde – menées par les journalistes de rédactions de quotidiens pour créer des SDJ dont la destination peut aller jusqu’à gouverner les journaux; de l’autre côté, les « réponses » apportées par les Pouvoirs politique et public pour contenir ces initiatives visant à étendre le pouvoir des journalistes dans la gestion et la gouvernance de leurs journaux. Cette étude exploratoire repose principalement sur l’analyse de deux types de littérature, souvent déconsidérés ou négligés par le champ académique, en dépit de leur grande richesse : (1 la littérature professionnelle, ayant pour principaux auteurs les journalistes et managers de presse (Périer Daville, Boegner, Pigasse, etc., florissante depuis 1944 et singulièrement durant les décennies 1960 et 1970 ; (2 la littérature grise constituée notamment par des rapports publics rédigés par des institutions comme les services du Premier ministre (commissions Lindon de 1970 et Serisé de 1972, le Conseil économique et social, etc. Nos principaux résultats montrent que les propositions ou actions menées par les journalistes (1 restent le plus souvent inexploitées in concreto par les journalistes eux-mêmes; (2 entrent le plus souvent en opposition avec les politiques de nouveaux actionnaires ou directions de journaux et avec les projets des autorités politiques et publiques qui cherchent à encadrer l’autonomie de la profession journalistique pour mieux gouverner celle-ci ; (3 combien in fine les représentants des différents acteurs impliqués s’accordent pour contenir l’émergence d’un « gouvernement des journalistes » par les

  8. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Homma, Taihei [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Shimizu, Miho [Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kuroda, Reiko, E-mail: ckuroda@mail.ecc.u-tokyo.ac.jp [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902 (Japan)

    2011-01-07

    Research highlights: {yields} The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. {yields} L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. {yields} Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  9. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    International Nuclear Information System (INIS)

    Homma, Taihei; Shimizu, Miho; Kuroda, Reiko

    2011-01-01

    Research highlights: → The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. → L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. → Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  10. Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis.

    Science.gov (United States)

    Lee, Hyejoo; Malaspina, Dolores; Ahn, Hongshik; Perrin, Mary; Opler, Mark G; Kleinhaus, Karine; Harlap, Susan; Goetz, Raymond; Antonius, Daniel

    2011-05-01

    Paternal age related schizophrenia (PARS) has been proposed as a subgroup of schizophrenia with distinct etiology, pathophysiology and symptoms. This study uses a k-means clustering analysis approach to generate hypotheses about differences between PARS and other cases of schizophrenia. We studied PARS (operationally defined as not having any family history of schizophrenia among first and second-degree relatives and fathers' age at birth ≥ 35 years) in a series of schizophrenia cases recruited from a research unit. Data were available on demographic variables, symptoms (Positive and Negative Syndrome Scale; PANSS), cognitive tests (Wechsler Adult Intelligence Scale-Revised; WAIS-R) and olfaction (University of Pennsylvania Smell Identification Test; UPSIT). We conducted a series of k-means clustering analyses to identify clusters of cases containing high concentrations of PARS. Two analyses generated clusters with high concentrations of PARS cases. The first analysis (N=136; PARS=34) revealed a cluster containing 83% PARS cases, in which the patients showed a significant discrepancy between verbal and performance intelligence. The mean paternal and maternal ages were 41 and 33, respectively. The second analysis (N=123; PARS=30) revealed a cluster containing 71% PARS cases, of which 93% were females; the mean age of onset of psychosis, at 17.2, was significantly early. These results strengthen the evidence that PARS cases differ from other patients with schizophrenia. Hypothesis-generating findings suggest that features of PARS may include a discrepancy between verbal and performance intelligence, and in females, an early age of onset. These findings provide a rationale for separating these phenotypes from others in future clinical, genetic and pathophysiologic studies of schizophrenia and in considering responses to treatment. Copyright © 2011 Elsevier B.V. All rights reserved.

  11. Electron microscope study of vacancy clusters produced by quenching in magnesium; Etude par microscopie electronique des amas de lacunes crees par trempe dans le magnesium

    Energy Technology Data Exchange (ETDEWEB)

    Levy, V; Espinasse, J; Mairy, C; Hillairet, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    Vacancy clustering in quenched magnesium has been studied by transmission electron microscopy. The nature of the vacancy loops observed, seems to depend essentially on the impurity content of the metal; this effect can be attributed to a variation of the stacking fault energy of magnesium due to impurities. (authors) [French] On a etudie par microscopie electronique en transmission les defauts crees par trempe dans le magnesium. Un effet considerable des impuretes du metal sur la nature des boucles obtenues par condensation de lacunes a ete mis en evidence; cet effet semble s'expliquer de facon satisfaisante par un abaissement de l'energie de faute d'empilement du magnesium du aux impuretes. (auteur)

  12. Neutrons detection by scintillation; Detection de neutrons par scintillations

    Energy Technology Data Exchange (ETDEWEB)

    Giraudon, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1955-01-15

    The absence of charge of neutrons and their elevated penetration power make difficult their detection. Techniques vary otherwise with the energy of the particle. The author proposes the realization of a scintillation detector with a big volume of liquid scintillator and containing boron for the detection of slowing-down neutrons in the domain of intermediate energies from 1 to 10{sup 5} eV about. (M.B.) [French] L'absence de charge du neutron et son pouvoir de penetration eleve rendent difficile sa detection. Les techniques par ailleurs varient avec l'energie de cette particule. L'auteur propose la realisation d'un detecteur a scintillations comprenant un grand volume de scintillateur liquide et contenant du bore pour la detection des neutrons en ralentissement dans le domaine des energies intermediaires de 1 a 10{sup 5} eV environ. (M.B.)

  13. Cancro em mogno africano no estado do Pará

    Directory of Open Access Journals (Sweden)

    Célia Regina Tremacoldi

    2013-06-01

    Full Text Available Sintomas de cancro foram observados em plantios de mogno africano, no município de Dom Eliseu, Pará. Os fungos associados aos tecidos sintomáticos foram identificados como Lasiodiplodia theobromae e Fusarium subglutinans. Culturas puras desses fungos foram testadas quanto à patogenicidade em mudas de mogno africano sadias. Apenas L. theobromae produziu cancro, por meio de inoculação por ferimento e alta umidade. A confirmação de L. theobromae como agente causal do cancro ocorreu após o reisolamento do fungo a partir das plantas inoculadas em casa de vegetação, concluindo a primeira verificação do postulado de Koch para esse patossistema.

  14. IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

    Directory of Open Access Journals (Sweden)

    René Klega

    2014-03-01

    Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

  15. Pierre Vilar Frontinhan 1906 - París 2003

    Directory of Open Access Journals (Sweden)

    Pablo Rodríguez

    2003-01-01

    Full Text Available En el pasado mes de agosto falleció en París el historiador y maestro de tantas generaciones Pierre Vilar. Aunque había mantenido una intensa actividad de reflexión sobre los sucesos contemporáneos, ésta se vio afectada en 1991 luego que una grave enfermedad le negó la visión. Fue entonces cuando decidió con la ayuda de Rosa Congost escribir sus reflexiones y recuerdos, especie de memoria de juventud. Pensar Históricamente (Barcelona: Editorial Crítica, 1997, el libro que reúne estos ejercicios, es una obra de sumo interés para conocer la infancia, adolescencia y juventud de este connotado historiador.

  16. Neutrons detection by scintillation; Detection de neutrons par scintillations

    Energy Technology Data Exchange (ETDEWEB)

    Giraudon, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1955-01-15

    The absence of charge of neutrons and their elevated penetration power make difficult their detection. Techniques vary otherwise with the energy of the particle. The author proposes the realization of a scintillation detector with a big volume of liquid scintillator and containing boron for the detection of slowing-down neutrons in the domain of intermediate energies from 1 to 10{sup 5} eV about. (M.B.) [French] L'absence de charge du neutron et son pouvoir de penetration eleve rendent difficile sa detection. Les techniques par ailleurs varient avec l'energie de cette particule. L'auteur propose la realisation d'un detecteur a scintillations comprenant un grand volume de scintillateur liquide et contenant du bore pour la detection des neutrons en ralentissement dans le domaine des energies intermediaires de 1 a 10{sup 5} eV environ. (M.B.)

  17. Determination of tritium by counting; Dosage du tritium par comptage

    Energy Technology Data Exchange (ETDEWEB)

    Schott, R; Froment, G; Pinson, J; Genty, C [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1968-07-01

    Ionisation chamber assay of tritium in any gaseous mixture is a simple, fast and accurate method. We used the method of relative determination by comparison to a standard rather than the method of absolute assay in which case the constants are known with too little accuracy. The efficiency of the chamber was studied in connection to the pressure inside the chamber and its total volume. The calibration is linear in the range we are taking into account (1 to 80 millicuries). The reproducibility of the method is good: 13 runs gave a coefficient of variation of 1.6 per cent. The relative accuracy was found equal to {+-} 1.3 per cent. To end the paper, we describe in detail the apparatus and the ways of proceedings. (authors) [French] Le comptage du tritium par chambre d'ionisation est une methode simple, rapide et precise pour determiner la teneur en tritium d'un melange gazeux quelconque. Nous avons prefere utiliser la methode de determination relative par rapport a un etalon car, dans le cas d'une determination absolue, les constantes sont connues avec une trop grande incertitude. L'efficacite de la chambre a ete etudiee en fonction de la variation de la pression d'argon a l'interieur de la chambre et du volume total, de cette derniere. L'etalonnage s'est revele lineaire dans le domaine de mesures qui nous interessaient (1 a 80 millicuries). La reproductibillte de la methode est tres bonne, le coefficient de variation pour une serie de 13 essais etant de 1,6 pour cent, quant a la precision relative, elle a ete evaluee a {+-} 1,3 pour cent. Pour terminer, nous donnons une description detaillee de l'appareillage utilise et du mode operatoire suivi. (auteurs)

  18. Clinical outcomes of pars plicata anterior vitrectomy: 2-year results

    Directory of Open Access Journals (Sweden)

    Priya Narang

    2015-01-01

    Full Text Available Purpose: To demonstrate the safety and outcome of a surgical approach that uses pars plicata site for anterior vitrectomy during phacoemulsification procedure complicated by posterior capsule rupture and residual cortical matter. Design: Single center, retrospective, interventional, noncomparative study. Materials and Methods: Medical records of a consecutive series of 35 eyes of 35 patients who underwent pars plicata anterior vitrectomy (PPAV were reviewed. The main outcome measures were corrected and uncorrected distance visual acuity (CDVA, UDVA, early and late postoperative complications and intraocular pressure (IOP. Ultrasound biomicroscopic (UBM evaluation of sclerotomy site and spectral domain optical coherence tomography analysis for central macular thickness (CMT was performed. The final visual outcome at 2 years was evaluated. Results: At 2 years follow-up, the mean postoperative UDVA (logarithm of the minimum angle of resolution [logMAR] and CDVA (logMAR was 0.49 ± 0.26 and 0.19 ± 0.14, respectively. There was no significant change in the IOP (P = 0.061 and the mean CMT at 2 years was 192.5 ± 5.54 mm. The postoperative UBM image of the sclerotomy site at 8 weeks demonstrated a clear wound without any vitreous adhesion or incarceration. Intraoperative hyphema was seen in 1 (2.8% case and postoperative uveitis was seen in 2 (5.7% cases, which resolved with medications. No case of an iatrogenic retinal break or retinal detachment was reported. Conclusions: PPAV enables a closed chamber approach, allows thorough cleanup of vitreous in the pupillary plane and anterior chamber and affords better access to the subincisional and retropupillary cortical remnant with a significant visual outcome and an acceptable complication rate.

  19. The Radioisotopic Determination of Diffusion Coefficients and Currents in Natural Waters. Surface Collection of Radioactive Fall-Out on a Large Alpine Lake; Determination par detection nucleaire des coefficients de diffusion et des courants dans les eaux naturelles. Evolution de la surface de collection d'un grand lac alpin pour les retombees radioactives; Opredelenie koehffitsienta diffuzii i skorosti techeniya estestvennykh vod pri pomoshchi yadernogo detektirovaniya. Ehvolyutsiya poverkhnosti sbora radioaktivnykh osadkov na bol'shom al'pijskom ozere; Determinacion por deteccion nuclear de los coeficientes de difusion y de las corrientes en las aguas naturales evolucion de la superficie de captacion de un gran lago alpino para las precipitaciones radiactivas

    Energy Technology Data Exchange (ETDEWEB)

    Chesselet, R.; Nordemann, D. [Service d' Electronique Physique, Centre d' Etudes Nucleaires de Saclay (France); Dussart, B. [Centre de Recherches Hydrobiologiques, CNRS, Gif-sur-Yvette (France)

    1963-08-15

    In an initial stage, the authors brought about the in situ diffusion of a radioactive emitter (sodium-22, in the form of Na{sup +}) with very low activity, i.e. less than 1 mc. The diffusion laws applied in this case made it easy to predict the rate of diffusing of the {sup r}adioactive cloud{sup .} In this way, plotting the activities, as measured by two suitably placed gamma detectors, against time permits the estimation of a diffusion coefficient for the emitter used and, if appropriate, the measurement of current velocity at the point of measurement (in the case described, the Lake of Geneva). Subsequently, and in conjunction with a geophysical study on the general problem of radioactive fall-out, the authors worked on the increases in radioactive fall-out caused by nuclear tests in the atmosphere (October 1961 - January 1962). Measurements of radioactivity were made every day on samples of Lake Geneva water taken at depths of 0 m, 10 m and 20 m and also on a collector of dry and moist atmospheric fall-out. Despite the complex pattern, over a period, of theincreasesinfall-out , the interpretation of the diagrams obtained can help to explain what happens to radioactive products in the diffusion and current conditions encountered. The use of the diffusion of radioactive products in very small quantities and of the various highly sensitive techniques of nuclear detection now available can lead to a better understanding of in situ diffusion and of the movement of natural water masses. (author) [French] Dans un premiere etape, les auteurs ont provoque la diffusion in situ d'un emetteur radioactif, le sodium 22, sous forme de Na{sup +}, avec des activites tres faibles, inferieures au millicurie. Les lois de la diffusion appliquee a ce cas permettent aisement de prevoir l'allure du 'n'uage radioactif'' en cours de diffusion. Ainsi, l'enregistrement en fonction du temps des activites mesurees par deux detecteurs gamma convenablemen t disposes conduit a l'evaluation d

  20. Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target

    DEFF Research Database (Denmark)

    Persson, Morten; Kjaer, Andreas

    2013-01-01

    modalities such as optical imaging, magnetic resonance imaging, single photon emission computer tomography (SPECT) and positron emission topography (PET). In this review, we will discuss recent advances in the development of uPAR-targeted imaging ligands according to imaging modality. In addition, we...... will discuss the potential future clinical application for uPAR imaging as a new imaging biomarker....

  1. Pars plana vitrectomy for disturbing primary vitreous floaters: clinical outcome and patient satisfaction

    NARCIS (Netherlands)

    Nie, K.F. de; Crama, N.; Tilanus, M.A.D.; Klevering, B.J.; Boon, C.J.F.

    2013-01-01

    BACKGROUND: Primary vitreous floaters can be highly bothersome in some patients. In the case of persistently bothersome floaters, pars plana vitrectomy may be the most effective treatment. The aim of this study is to evaluate the incidence of complications, and patient satisfaction, after pars plana

  2. Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

    Science.gov (United States)

    Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

    2015-10-01

    The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Spectral variations of UV-A and PAR solar radiation in estuarine waters of Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Talaulikar, M.; Suresh, T.; Silveira, N.; Desa, E.; Matondkar, S; Lotlikar, A

    radiation (400 to 700 nm), PAR and ultraviolet radiation in the range 350-400 nm (UV-A) are presented here. The mean PAR values at the surface were 327 W/m sup(2) and reduced to 84 W/m sup(2) at first optical depth, Z sub(90) (m) in water. The first optical...

  4. Narrative Identities and the Plebiscite in Pará: An Analysis of the Front Pages for O Liberal and Diário do Pará

    Directory of Open Access Journals (Sweden)

    Alda Cristina Silva da Costa

    2017-05-01

    Full Text Available On December 11, 2011, a plebiscite was held in Pará proposing to create two separatist states, Carajás and Tapajós, out of the state of Pará. The public voted against both projects. This article analyzes the narrative identities found on the front pages of O Liberal and Diário do Pará newspapers about the plebiscite in Pará. Depth Hermeneutics (DH, as proposed by Thompson (2011, was used as the methodological reference. DH emphasizes the object of analysis as a meaningful symbolic construction requiring interpretation. Narrative analysis, as proposed by Motta (2007, was the main research technique used to highlight the movement of construction of journalistic (discursive characters. The narrative identities built by the two newspapers showed that both were against the creation of the new states, but for very different reasons. The flag of Pará was the main object used to induce the idea of unity. Em 11 de dezembro de 2011, o plebiscito no Pará propôs a criação dos estados de Carajás e de Tapajós a partir da divisão do estado do Pará. O resultado da consulta pública foi negativo aos dois projetos. O artigo analisa as identidades narrativas constituídas pelas primeiras páginas dos jornais O Liberal e Diário do Pará sobre o plebiscito no Pará. Utilizou-se como referencial metodológico a Hermenêutica em Profundidade (HP, proposta por Thompson (2011. A HP evidencia o fato de que o objeto de análise é uma construção simbólica significativa, que exige uma interpretação. Como principal técnica de pesquisa, a análise narrativa, proposta por Motta (2007, com ênfase no movimento de construção de personagens jornalísticas (discursivas. As identidades narrativas construídas pelos dois jornais indicaram que ambos eram contrários à criação dos novos estados, porém por motivos divergentes. A bandeira do Pará foi o principal elemento utilizado para evocar a ideia de unidade. En 11 de diciembre de 2011, el plebiscito en

  5. The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180)

    DEFF Research Database (Denmark)

    Behrendt, Niels

    2004-01-01

    The breakdown of the barriers formed by extracellular matrix proteins is a pre-requisite for all processes of tissue remodeling. Matrix degradation reactions take part in specific physiological events in the healthy organism but also represent a crucial step in cancer invasion. These degradation...... on the surface of various cell types that serves to bind the urokinase plasminogen activator and localize the activation reactions in the proteolytic cascade system of plasminogen activation. uPARAP is an integral membrane protein with a pronounced role in the internalization of collagen for intracellular...... degradation. Both receptors have additional functions that are currently being unraveled. The present discussion of uPAR and uPARAP is centered on their protein structure and molecular and cellular function....

  6. Effect of simvastatin and ezetimibe on suPAR levels and outcomes

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Forman, Julie L

    2018-01-01

    -lowering therapy also lowers suPAR levels is unknown. METHODS: We investigated whether treatment with Simvastatin 40 mg and Ezetimibe 10 mg lowered plasma suPAR levels in 1838 patients with mild-moderate, asymptomatic aortic stenosis, included in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, using...... and Ezetimibe treatment impeded the progression of the time-related increase in plasma suPAR levels. Year-1 suPAR was associated with all-cause mortality, MCE, and AVE irrespective of baseline levels (SEAS study: NCT00092677)....... cardiovascular events (MCE) composed of ischemic cardiovascular events (ICE) and aortic valve related events (AVE). RESULTS: After 4.3 years of follow-up, suPAR levels had increased by 9.2% (95% confidence interval [CI]: 7.0%-11.5%) in the placebo group, but only by 4.1% (1.9%-6.2%) in the group with lipid...

  7. Brulure par Plaque de Bistouri Electrique: a Propos de Quatre Cas

    Science.gov (United States)

    Khales, A.; Achbouk, A.; Belmir, R.; Cherkab, L.; Ennouhi, M.A.; Ababou, K.; Ihrai, H.

    2010-01-01

    Summary La brûlure par plaque de bistouri électrique est un accident rare mais grave par la profondeur de la lésion et par sa localisation, surtout quand qu’elle survient dans un contexte chirurgical dont le vécu reste difficile de la part du malade et du chirurgien. Cette brûlure bien que imprévisible reste grave par la profondeur et la localisation de la brûlure et par sa survenue dans un contexte opératoire, chez des patients malades. La prise en charge de la brûlure doit se faire en milieu spécialisé. La prévention reste le seul moyen d’éviter ce type d’accident. PMID:21991216

  8. par genes in Mycobacterium bovis and Mycobacterium smegmatis are arranged in an operon transcribed from "SigGC" promoters

    Directory of Open Access Journals (Sweden)

    Casart Yveth

    2008-03-01

    Full Text Available Abstract Background The ParA/Soj and ParB/Spo0J proteins, and the cis-acting parS site, participate actively in chromosome segregation and cell cycle progression. Genes homologous to parA and parB, and two putative parS copies, have been identified in the Mycobacterium bovis BCG and Mycobacterium smegmatis chromosomes. As in Mycobacterium tuberculosis, the parA and parB genes in these two non-pathogenic mycobacteria are located near the chromosomal origin of replication. The present work focused on the determination of the transcriptional organisation of the ~6 Kb orf60K-parB region of M. bovis BCG and M. smegmatis by primer extension, transcriptional fusions to the green fluorescence protein (GFP and quantitative RT-PCR. Results The parAB genes were arranged in an operon. However, we also found promoters upstream of each one of these genes. Seven putative promoter sequences were identified in the orf60K-parB region of M. bovis BCG, whilst four were identified in the homologous region of M. smegmatis, one upstream of each open reading frame (ORF. Real-time PCR assays showed that in M. smegmatis, mRNA-parA and mRNA-parB levels decreased between the exponential and stationary phases. In M. bovis BCG, mRNA-parA levels also decreased between the exponential and stationary phases. However, parB expression was higher than parA expression and remained almost unchanged along the growth curve. Conclusion The majority of the proposed promoter regions had features characteristic of Mycobacterium promoters previously denoted as Group D. The -10 hexamer of a strong E. coli σ70-like promoter, located upstream of gidB of M. bovis BCG, overlapped with a putative parS sequence, suggesting that the transcription from this promoter might be regulated by the binding of ParB to parS.

  9. MODIS-derived daily PAR simulation from cloud-free images and its validation

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Liangfu; Gu, Xingfa; Tian, Guoliang [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); The Center for National Spaceborne Demonstration, Beijing 100101 (China); Gao, Yanhua [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101 (China); Yang, Lei [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China); Jilin University, Changchun 130026 (China); Liu, Qinhuo [State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences and Beijing Normal University, Beijing 100101 (China)

    2008-06-15

    In this paper, a MODIS-derived daily PAR (photosynthetically active radiation) simulation model from cloud-free image over land surface has been developed based on Bird and Riordan's model. In this model, the total downwelling spectral surface irradiance is divided into two parts: one is beam irradiance, and another is diffuse irradiance. The attenuation of solar beam irradiance comprises scattering by the gas mixture, absorption by ozone, the gas mixture and water vapor, and scattering and absorption by aerosols. The diffuse irradiance is scattered out of the direct beam and towards the surface. The multiple ground-air interactions have been taken into account in the diffuse irradiance model. The parameters needed in this model are atmospheric water vapor content, aerosol optical thickness and spectral albedo ranging from 400 nm to 700 nm. They are all retrieved from MODIS data. Then, the instantaneous photosynthetically available radiation (IPAR) is integrated by using a weighted sum at each of the visible MODIS wavebands. Finally, a daily PAR is derived by integration of IPAR. In order to validate the MODIS-derived PAR model, we compared the field PAR measurements in 2003 and 2004 against the simulated PAR. The measurements were made at the Qianyanzhou ecological experimental station, Chinese Ecosystem Research Network. A total of 54 days of cloud-free MODIS L1B level images were used for the PAR simulation. Our results show that the simulated PAR is consistent with field measurements, where the correlation coefficient of linear regression between calculated PAR and measured PAR is 0.93396. However, there were some uncertainties in the comparison of 1 km pixel PAR with the tower flux stand measurement. (author)

  10. Design of an equipment for the testing of target dedicated to the production of radioactive ions through the ISOL method; Realisation d'un dispositif de test de cibles pour la production d'ions radioactifs par la methode ISOL

    Energy Technology Data Exchange (ETDEWEB)

    Durantel, F

    2005-01-15

    In the ISOL (isotope separation on line) technique, a primary ion beam impinges on a thick target, the incident ions are stopped through fragmentation reactions that generate radioactive nuclei. As soon as they have collected enough electrons, the radioactive nuclei begin diffusing outside the target as radioactive atoms. In order to improve this diffusion the target is strongly heated. The radioactive atoms diffuse till a ion source that ionize them, they are then accelerated to form a secondary beam that is delivered to the experimental area. This work deals with the design of an equipment able to measure the diffusion capacities of various targets, it is made up of -) a high temperature (> 2300 K) oven that will contain the target, -) a ionization source for ionizing radioactive atoms and -) a target dispatcher able to introduce in the oven or remove from the oven any target of a set of 12 targets. This equipment has proved to be able to test during a single experiment several primary beams and target materials. Measurements will be performed in a sequential way for the different projectile-target couples which will assure very closed experimental conditions for each measuring campaign. (A.C.)

  11. Study of deuterons induced nuclear reactions on light elements (N, Al and Si): Application to containment materials of radioactive wastes; Etude des reactions nucleaires induites par des deuterons sur des elements legers (N, Al, Si): application aux materiaux de confinement des dechets radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Pellegrino, St

    2004-03-01

    Nuclear reaction analysis is well adapted to the quantification of light element. Profiles of concentration in order to follow elements migration into materials can be undertaken. This technique is used to study the behavior of the future matrices for nuclear waste containment. This technique is isotopic, characterized by a good signal-to-background ratio and a very low detection limit. The probability of a nuclear reaction is linked to a parameter called 'cross section' we have to know in order to carry out quantitative analysis. We have determined excitation curves for nitrogen, aluminium and silicon. These experiments were done with deuterons from 0.5 to 2 MeV. Two methods for the cross section characterization are presented and are in agreement with each other. The second one reduces uncertainty. Data are incorporated in the simulation software SIMNRA. We have compared the results obtained on different samples when we use data in literature or data of the study. We have noticed a great fit improvement with the data of this study. The new cross sections of this work will be integrated in the general data base SIGMABASE. Applications on materials such as Si{sub 3}N{sub 4}, nano-metric powders, WCN and nuclear glass YLaMgSiAlON studied for radioactive waste containment are also presented. (author)

  12. Presentation of the policy bill of program on the radioactive materials and wastes management by Francois Loos, Ministry delegate to the Industry, National Assembly; Presentation du projet de loi de programme sur la gestion des matieres et dechets radioactifs par Francois Loos, ministre delegue a l'Industrie, Assemblee Nationale

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-04-15

    This document provides the text of the presentation of Francois Loos. The bill institutes a national radioactive materials and waste management plan and defines a programme and calendar for research and work leading to implementation of this plan, which will comprise three major points: with a view to looking to reduce the quantity of waste, spent nuclear fuels taken from the nuclear power plants will be reprocessed for recycling in the plants; waste which cannot be recycled will be packaged in a robust matrix and then temporarily stored on the surface; after interim storage, waste which cannot be finally disposed of in a surface facility, will be placed in a deep geological reversible repository. In order to monitor each step in this plan, the bill strengthens independent assessment of research and involves greater information of the public. With regard to financing, the bill clarifies the fact that economic development of the departments concerned by research into disposal options and the research itself will be financed by additional taxes on the operators of nuclear installations. (A.L.B.)

  13. Law project adopted by the National Assembly, after urgency declaration, of the program relative to the sustainable management of radioactive materials and wastes; Projet de loi adopte par l'Assemblee Nationale, apres declaration d'urgence, de programme relatif a la gestion durable des matieres et des dechets radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The document presents the different articles of the law project dealing with the terminology, the radioactive wastes storage and disposal, the safety and the transport, the financing, the liabilities, the control and the sanctions. (A.L.B.)

  14. Control of radioactive wastes and coupling of neutron/gamma measurements: use of radiative capture for the correction of matrix effects that penalize the fissile mass measurement by active neutron interrogation; Controle des dechets radioactifs et couplage de mesures neutron/gamma: exploitation de la capture radiative pour corriger les effets de matrice penalisant la mesure de la masse fissile par interrogation neutronique active

    Energy Technology Data Exchange (ETDEWEB)

    Loche, F

    2006-10-15

    In the framework of radioactive waste drums control, difficulties arise in the nondestructive measurement of fissile mass ({sup 235}U, {sup 239}Pu..) by Active Neutron Interrogation (ANI), when dealing with matrices containing materials (Cl, H...) influencing the neutron flux. The idea is to use the neutron capture reaction (n,{gamma}) to determine the matrix composition to adjust the ANI calibration coefficient value. This study, dealing with 118 litres, homogeneous drums of density less than 0,4 and composed of chlorinated and/or hydrogenated materials, leads to build abacus linking the {gamma} ray peak areas to the ANI calibration coefficient. Validation assays of these abacus show a very good agreement between the corrected and true fissile masses for hydrogenated matrices (max. relative standard deviation: 23 %) and quite good for chlorinated and hydrogenated matrices (58 %). The developed correction method improves the measured values. It may be extended to 0,45 density, heterogeneous drums. (author)

  15. Program law n. 2006-739 of the 28 June 2006 relative to the sustainable management of radioactive materials and wastes: presentation by article; La loi de programme n. 2006-739 du 28 juin 2006 relative a la gestion durable des matieres et dechets radioactifs: presentation par article

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The french law of 1991, decided to define management solutions in the radioactive wastes management policy, is now over. The results of researches led to the promulgation of a new planing act, the law of the 28 June 2006. This law concerns the sustainable management of radioactive materials and wastes. It takes also in account a public debate, organized in September 2005 by the National Commission for Public Debate. The Law project architecture can be described in three main points: the implementing of a national policy of radioactive materials and wastes, a better transparency and democratic control and the implementing of specific modalities for the organization and the financing of spent fuels and radioactive wastes management. This document presents what is in the different articles, with a special attention to the contributions of the parliamentary debate. (A.L.B.)

  16. Results of several years experiments on the absorption of radioactive strontium and caesium by cultivated plants (1962); Compte rendu d'experiences de plusieurs annees sur l'absorption du strontium et du cesium radioactifs par des plantes cultivees (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Michon, M. [Commissariat a l' Energie Atomique, Dept. de Protection Sanitaire, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires; Benard, M.; Flanzy, M. [Station Centrale de Technologie des Produits Vegetaux, 11 - Narbonne (France); Fioramonti, M.; Marty, M. [Station Agronomique de Toulouse, 31 (France); Barbier, M.; Le Blaye, M.; Brossard, M. [Societe Centrale d' Agronomie, 78 - Versailles (France)

    1962-07-01

    This report follows on to the report number CEA 1860 and uses results obtained in 1960 to give more precise details concerning the data presented in the preceding report. First results obtained on the vine are given. The Sr absorption coefficient has varied very little from one year to the next and that of caesium has slightly diminished. The values obtained suggest that the concentrations of {sup 90}Sr and {sup 137}Cs in irrigation water should not exceed 1/5 of the maximum permissible concentration in drinking water. (authors) [French] Ce rapport fait suite au rapport CEA 1860 et precise grace aux resultats acquis en 1960 les donnees exprimees dans le precedent rapport. Il y est fait mention des premiers resultats obtenus pour la vigne. Le coefficient d'absorption du Sr a peu varie d'une annee sur l'autre et celui du cesium legerement diminue. Les valeurs obtenues permettent de penser qu'il serait souhaitable que la concentration en {sup 90}Sr et en {sup 137}Cs dans l'eau d'irrigation ne depasse pas le 1/5 de la concentration maxima admissible pour l'eau de boisson. (auteurs)

  17. The main evolutions brought by the parliamentary examination to the program law relative to the sustainable management of radioactive materials and wastes; Les principales evolutions apportees par l'examen parlementaire a la loi de programme relative a la gestion durable des matieres et dechets radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-07-01

    The french law of 1991, decided to define management solutions in the radioactive wastes management policy, is now over. The results of researches led to the promulgation of a new planing act, the law of the 28 June 2006. This law concerns the sustainable management of radioactive materials and wastes. It takes also in account a public debate, organized in September 2005 by the National Commission for Public Debate. The Law project architecture can be described in three main points: the implementing of a national policy of radioactive materials and wastes, a better transparency and democratic control and the implementing of specific modalities for the organization and the financing of spent fuels and radioactive wastes management. After the parliamentary examination, the text prepared by the Government was modified. This document presents the main four themes of modification. (A.L.B.)

  18. Study and development of a method allowing the identification of actinides inside nuclear waste packages, by active neutron or photon interrogation and delayed gamma-ray spectrometry; Etude et developpement d'une technique de dosage des actinides dans les colis de dechets radioactifs par interrogation photonique ou neutronique active et spectrometrie des gamma retardes

    Energy Technology Data Exchange (ETDEWEB)

    Carrel, F

    2007-10-15

    An accurate estimation of the alpha-activity of a nuclear waste package is necessary to select the best mode of storage. The main purpose of this work is to develop a non-destructive active method, based on the fission process and allowing the identification of actinides ({sup 235}U, {sup 238}U, {sup 239}Pu). These three elements are the main alpha emitters contained inside a package. Our technique is based on the detection of delayed gammas emitted by fission products. These latter are created by irradiation with the help of a neutron or photon beam. Performances of this method have been investigated after an Active Photon or Neutron Interrogation (INA or IPA). Three main objectives were fixed in the framework of this thesis. First, we measured many yields of photofission products to compensate the lack of data in the literature. Then, we studied experimental performances of this method to identify a given actinide ({sup 239}Pu in fission, {sup 235}U in photofission) present in an irradiated mixture. Finally, we assessed the application of this technique on different mock-up packages for both types of interrogation (118 l mock-up package containing EVA in fission, 220 l mock-up package with a wall of concrete in photofission). (author)

  19. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian

    2010-01-01

    -suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives...... and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR....

  20. Contribution to a research on electron beam welding of metals; Contribution a l'etude de la soudure des metaux par faisceau d'electrons

    Energy Technology Data Exchange (ETDEWEB)

    Stohr, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-03-15

    faisceau d'electrons. Le processus de soudure peut donc s'expliquer de la facon suivante: Le metal fondu est repousse vers le haut par la pression des electrons, coule vers le bas lorsque le faisceau se deplace et remplit la cavite precedemment creee. L'existence d'un cordon de soudure confirme ce point de vue; les radioimages obtenues a partir de sections droites de pieces comportants des traceurs radioactifs, montrent bien le brassage resultant de l'ecoulement du metal. En fait, le templissage de la cavite s'opere par le metal fondu provenant a la fois de la partie superieure de la piece et de la partie laterale arriere de la cavite (en considerant le sens du mouvement). La profondeur de penetration depend egalement des caracteristiques des materiaux; les essais effectues sur des pieces en Cu, Fe, Al montrent que cette profondeur de penetration est pratiquement proportionnelle a la chaleur specifique, on obtient dans le cas precite: h(Al) / C(Al) = h (Fe) / C (Fe) h (Cu) / C (Cu) cette proportionnalite cesse d'etre vraie lorsque l'on soude des alliages dont un ou plusieurs elements d'addition presentent une notable tension de vapeur a la temperature de fusion. En effet, les essais effectues sur l'aluminium et sur l'alliage Al-Mg montrent un accroisment notable de la profondeur de penetration pour ce dernier, bien que les chaleurs specifiques soient pratiquement identiques. Cet accroissement de la profondeur de penetration peut s'expliquer par l'aide qu'apporte a la formation de la cavite, la pression creee par l'element d'addition a tension de vapeur elevee. Les micrographies effectuees sur des pieces soudees de metaux divers, montrent des segregations de fonderie semblables a celles que l' obtient lorsqu'on remplit un moule a grand elancement. On peut signaler au passage que la configuration geometrique prise par ces segregations confirme l'hypothese de l'ecoulement du metal tel qu'il a ete envisage precedemment. L'etude de ces segregations, mises en evidence par examen

  1. Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis

    Science.gov (United States)

    Stanton, M. Mark; Nelson, Lisa K.; Benediktsson, Hallgrimur; Hollenberg, Morley D.; Buret, Andre G.; Ceri, Howard

    2013-01-01

    Background. Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. Methods. Using a hapten (ethanol-dinitrobenzene sulfonic acid- (DNBS-)) induced prostatitis model with both wild-type and PAR1-null mice, we examined (1) the location of PAR1 in the mouse prostate and (2) the impact of a PAR1-activating peptide (TFLLR-NH2: PAR1-TF) on ethanol-DNBS-induced inflammation. Results. Ethanol-DNBS-induced inflammation was maximal at 2 days. In the tissue, PAR1 was expressed predominantly along the apical acini of prostatic epithelium. Although PAR1-TF on its own did not cause inflammation, its coadministration with ethanol-DNBS reduced all indices of acute prostatitis. Further, PAR1-TF administration doubled the prostatic production of interleukin-10 (IL-10) compared with ethanol-DNBS treatment alone. This enhanced IL-10 was not observed in PAR1-null mice and was not caused by the reverse-sequence receptor-inactive peptide, RLLFT-NH2. Surprisingly, PAR1-TF, also diminished ethanol-DNBS-induced inflammation in PAR1-null mice. Conclusions. PAR1 is expressed in the mouse prostate and its activation by PAR1-TF elicits immunomodulatory effects during ethanol-DNBS-induced prostatitis. However, PAR1-TF also diminishes ethanol-DNBS-induced inflammation via a non-PAR1 mechanism by activating an as-yet unknown receptor. PMID:24459330

  2. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Directory of Open Access Journals (Sweden)

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  3. Comparaison du Pangola (Digitaria decumbens) et du Stargrass (Cynodon nlemfluensis) exploités par des ovins

    OpenAIRE

    Boval, Maryline

    1989-01-01

    A la Martinique l'utilisation comparée de Digitaria decumbens (Dd) et de Cynodon nlemfuensis (Cn) par des brebis allaitantes a été étudiée pendant une période d'observation de 6 mois. Le cheptel est à un taux élevé de 1 600 kg de poids vif par hectare et par an, obtenu par une fertilisation de 450 kg/ha/an en azote.

  4. Improved Satellite-based Photosysnthetically Active Radiation (PAR) for Air Quality Studies

    Science.gov (United States)

    Pour Biazar, A.; McNider, R. T.; Cohan, D. S.; White, A.; Zhang, R.; Dornblaser, B.; Doty, K.; Wu, Y.; Estes, M. J.

    2015-12-01

    One of the challenges in understanding the air quality over forested regions has been the uncertainties in estimating the biogenic hydrocarbon emissions. Biogenic volatile organic compounds, BVOCs, play a critical role in atmospheric chemistry, particularly in ozone and particulate matter (PM) formation. In southeastern United States, BVOCs (mostly as isoprene) are the dominant summertime source of reactive hydrocarbon. Despite significant efforts in improving BVOC estimates, the errors in emission inventories remain a concern. Since BVOC emissions are particularly sensitive to the available photosynthetically active radiation (PAR), model errors in PAR result in large errors in emission estimates. Thus, utilization of satellite observations to estimate PAR can help in reducing emission uncertainties. Satellite-based PAR estimates rely on the technique used to derive insolation from satellite visible brightness measurements. In this study we evaluate several insolation products against surface pyranometer observations and offer a bias correction to generate a more accurate PAR product. The improved PAR product is then used in biogenic emission estimates. The improved biogenic emission estimates are compared to the emission inventories over Texas and used in air quality simulation over the period of August-September 2013 (NASA's Discover-AQ field campaign). A series of sensitivity simulations will be performed and evaluated against Discover-AQ observations to test the impact of satellite-derived PAR on air quality simulations.

  5. Pars plana Ahmed valve and vitrectomy in patients with glaucoma associated with posterior segment disease.

    Science.gov (United States)

    Wallsh, Josh O; Gallemore, Ron P; Taban, Mehran; Hu, Charles; Sharareh, Behnam

    2013-01-01

    To assess the safety and efficacy of a modified technique for pars plana placement of the Ahmed valve in combination with pars plana vitrectomy in the treatment of glaucoma associated with posterior segment disease. Thirty-nine eyes with glaucoma associated with posterior segment disease underwent pars plana vitrectomy combined with Ahmed valve placement. All valves were placed in the pars plana using a modified technique, without the pars plana clip, and using a scleral patch graft. The 24 eyes diagnosed with neovascular glaucoma had an improvement in intraocular pressure from 37.6 mmHg to 13.8 mmHg and best-corrected visual acuity from 2.13 logarithm of minimum angle of resolution to 1.40 logarithm of minimum angle of resolution. Fifteen eyes diagnosed with steroid-induced glaucoma had an improvement in intraocular pressure from 27.9 mmHg to 14.1 mmHg and best-corrected visual acuity from 1.38 logarithm of minimum angle of resolution to 1.13 logarithm of minimum angle of resolution. Complications included four cases of cystic bleb formation and one case of choroidal detachment and explantation for hypotony. Ahmed valve placement through the pars plana during vitrectomy is an effective option for managing complex cases of glaucoma without the use of the pars plana clip.

  6. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  7. The pars intermedia: an anatomic basis for a coordinated vascular response to female genital arousal.

    Science.gov (United States)

    Shih, Cheryl; Cold, Christopher J; Yang, Claire C

    2013-06-01

    The pars intermedia is an area of the vulva that has been inconsistently described in the literature. We conducted anatomic studies to better describe the tissues and vascular structures of the pars intermedia and proposed a functional rationale of the pars intermedia in the female sexual response. Nine cadaveric vulvectomy specimens were used. Each was serially sectioned and stained with hematoxylin and eosin and Masson's trichrome. Histologic ultrastructural description of the pars intermedia. The pars intermedia contains veins traveling longitudinally in the angle of the clitoris, supported by collagen-rich stromal tissues. These veins drain the different vascular compartments of the vulva, including the clitoris, the bulbs, and labia minora; also, the interconnecting veins link the different vascular compartments. The pars intermedia is not composed of erectile tissue, distinguishing it from the erectile tissues of the corpora cavernosa of the clitoris as well as the corpus spongiosum of the clitoral (vestibular) bulbs. The venous communications of the pars intermedia, linking the erectile tissues with the other vascular compartments of the vulva, appear to provide the anatomic basis for a coordinated vascular response during female sexual arousal. © 2012 International Society for Sexual Medicine.

  8. Hunger amidst plenty along the coast of Pará

    Directory of Open Access Journals (Sweden)

    Ivete Nascimento

    2006-08-01

    Full Text Available In this work one analyzes some referring questions to the new significações of the temporality constructed socially enters the artisan fishing of the coast, in the city of Maracanã, using as boundary-maker the concepts the concepts of abundance and famitura the one that they send themselves to the speech in way of life of the past and the gift. It will see as the typical way of life of the rescued past of the memory of old and the meaning of the abundance in the time of the fishing-farmer, the counterpoint with the concept of famitura of the fishing-exclusive of the gift, where the loss surpasses the scope of the strict survival reaching the proper way of life with the weakness of solidarity. This analysis will be given mecanicamente in the conceptual field of the time measured for the tasks and of the time chronometered for the clock. The intensive field work ocurred on Fortaleza of the Mocooca community incorporating data gotten a long the author's experience in the fish artisan thematic of the Pará coast.

  9. Le Web pour enseigner par projets et favoriser la collaboration

    Directory of Open Access Journals (Sweden)

    Sylvie Ratté

    2004-01-01

    Full Text Available L’utilisation du Web présentée dans cet article vient appuyer une démarche pédagogique fondée sur le partage des savoirs. Dans le contexte d’une simulation industrielle, les étudiants d’un cours de programmation avancée doivent apprendre à partager leur expertise, à communiquer clairement leurs questions, à décrire des problèmes et à faire face à des retournements inattendus. Le Web devient un espace de collaboration pour diffuser les requêtes d’un client fictif, les directives, les travaux préliminaires et les ententes. Les résultats obtenus tendent à suggérer que cette approche globale force l’étudiant à mieux planifier, l’invite à mieux formuler et décrire les problèmes, augmente le niveau de collaboration et facilite la production d’analogies. Un système facilitant la logistique entourant la revue par les pairs (récupération des travaux, construction d’une grille d’évaluation et diffusion des résultats est également présenté.

  10. Design of 118 MHz twelfth harmonic cavity of APS PAR

    International Nuclear Information System (INIS)

    Kang, Y.W.; Kustom, R.L.; Bridges, J.F.

    1992-01-01

    Two radio frequency (RF) cavities are needed in the Positron Accumulator Ring (PAR) of the Advanced Photon Source. One is for the first harmonic frequency at 9.8 MHz, and the other is for the twelfth harmonic frequency at 118 MHz. This note reports on the design of the 118 MHz RF cavity. Computer models are used to find the mode frequencies, impedances, Q-factors, and field distributions in the cavity. The computer codes MAFIA, URMEL, and URMEL-T are useful tools which model and simulate the resonance characteristics of a cavity. These codes employ the finite difference method to solve Maxwell's equations. MAFIA is a three-dimensional problem solver and uses square patches to approximate the inner surface of a cavity. URMEL and URMEL-T are two-dimensional problem solvers and use rectangular and triangular meshes, respectively. URMEL-T and MAFIA can handle problems with arbitrary dielectric materials located inside the boundary. The cavity employs a circularly cylindrical ceramic window to limit the vacuum to the beam pipe. The ceramic window used in the modeling will have a wall thickness of 0.9 cm. This wall thickness is not negligible in determining the resonant frequencies of the cavity. In the following, results of two- and three-dimensional modeling of the cavities using the URMEL-T and MAFIA codes are reported

  11. Characterization of ParTI Phoswiches Using Charged Pion Beams

    Science.gov (United States)

    Churchman, Emily; Zarrella, Andrew; Youngs, Michael; Yennello, Sherry

    2017-09-01

    The Partial Truncated Icosahedron (ParTI) detector array consists of 15 phoswiches. Each phoswich is made of two scintillating components - a thallium-doped cesium iodide (CsI(Tl)) crystal and an EJ-212 scintillating plastic - coupled to a photomultiplier tube. Both materials have different scintillation times and are sensitive to both charged and neutral particles. The type of particle and amount of energy deposited determine the shape of the scintillation pulse as a function of time. By integrating the fast and slow signals of the scintillation pulses, a ``Fast vs. Slow Integration'' plot can be created that produces particle identification lines based on the energy deposited in the scintillating materials. Four of these phoswiches were taken to the Paul Scherrer Institute (PSI) in Switzerland where π + , π-, and proton beams were scattered onto the phoswiches to demonstrate their particle identification (PID) capabilities. Using digitizers to record the detector response waveforms, pions can also be identified by the characteristic decay pulse of the muon daughters.

  12. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Semenas Liliana

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  13. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  14. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Hong-hua; Zhang, Xi; Cao, Pei-guo [Department of Oncology, the Third Xiangya Hospital, Central South University, Changsha, Hunan Province (China)

    2011-11-18

    The matrix metalloprotease-1 (MMP-1)/protease-activated receptor-1 (PAR-1) signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC), we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9%) and 58 (68.2%) tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM) stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS) than those with negative ESCC (P = 0.002 and 0.003, respectively). Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR) = 2.836, 95% confidence interval (CI) = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068), MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127), and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883) and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681), MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279), and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881) as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  15. Prognostic value of suPAR and hs-CRP on cardiovascular disease

    DEFF Research Database (Denmark)

    Diederichsen, Marie Zöga; Diederichsen, Søren Zöga; Mickley, Hans

    2018-01-01

    Background and aims: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP...... have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. Methods: A population sample of 1179 subjects, free of CV disease was included. The subjects underwent traditional CV risk evaluation, CAC assessment and blood sampling for suPAR and CRP. CV events...

  16. Profils des enfants infectes par le vih en debut du traitement ...

    African Journals Online (AJOL)

    But : Décrire les profils des enfants infectés par le VIH au début du traitement antirétroviral. Matériels et méthode: Les dossiers des enfants infectés par le VIH dans la région maritime ont été analysés de mai 2008 à février 2010 par le comité thérapeutique. Résultats: Parmi les 96 dossiers analysés, 66,67% venaient du ...

  17. Les dispensées par fantaisie en éducation physique et sportive ...

    African Journals Online (AJOL)

    Cette étude vise à comprendre les raisons avancées par les élèves dispensés par fantaisie des cours d'EPS, pour justifier leur attitude et principalement leur forfait. Une enquête par questionnaire écrit a été menée dans 13 établissements publics de la ville de Porto-Novo au Bénin. Au total, 203 élèves parmi les 771 élèves ...

  18. MODELISATION DE LA CINETIQUE CHIMIQUE DANS LA REDUCTION DES OXYDES D4AZOTE PAR DECHARGE COURONNE.

    OpenAIRE

    MEDJAHDI, Sarah ines

    2015-01-01

    CE TRAVAIL DE recherche rentre dans le cadre général de modélisation de la réduction des oxydes d'azote . l'utilisation des réacteurs a plasma froid non-thermique généré par des décharges couronnes est actuellement l'une des techniques les puis promettre .ses pour la destruction des oxydes d'azote .en effet , le traitement des gaz pollués par les décharges couronnes est notamment rendu possible par la multiplication des décharges Électriques .

  19. Thrombin induces rapid PAR1-mediated non-classical FGF1 release

    International Nuclear Information System (INIS)

    Duarte, Maria; Kolev, Vihren; Soldi, Raffaella; Kirov, Alexander; Graziani, Irene; Oliveira, Silvia Marta; Kacer, Doreen; Friesel, Robert; Maciag, Thomas; Prudovsky, Igor

    2006-01-01

    Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis

  20. Complexation de l'aluminium par des hétéropolyanions lacunaires ...

    African Journals Online (AJOL)

    L'objectif visé par cette étude est la dépollution des eaux à partir de la complexation d'un métal toxique, l'aluminium en solution, par des hétéropolyanions lacunaires (HPA) de type Dawson. Les complexes formés sont récupérés par membrane liquide émulsionnée (MEL).Les résultats de la complex1ation de l'aluminium ...

  1. Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

    International Nuclear Information System (INIS)

    Wilde, E.W.; Tilly, L.J.

    1985-02-01

    Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)

  2. Monoradiculopathy and secondary segmental instability caused by postoperative pars interarticularis fracture: a case report.

    Science.gov (United States)

    Kaner, Tuncay; Tutkan, Ibrahim

    2009-04-01

    Instability can develop after lumbar spinal surgery. What is also known as secondary segmental instability is one of the important causes of failed back syndrome. In this paper, we described a 45-year-old female patient who was diagnosed with secondary segmental instability caused by left L3 pars interarticularis fracture after a high lumbar disc surgery and was subsequently treated with re-operation. We evaluated the clinical course, diagnosis, and treatment methods for secondary segmental instability caused by postoperative pars interarticularis fracture. Furthermore, we emphasized the importance of preserving the pars interarticularis during upper lumbar disc surgeries in order to avoid a potential stress fracture.

  3. Influencia de los parámetros de proceso, en el comportamiento del parámetro vibración absoluta en turbinas de vapor.

    Directory of Open Access Journals (Sweden)

    F. de la Torre Silva

    2008-01-01

    Full Text Available Este trabajo muestra el estudio realizado en turbinas de vapor de pequeña capacidad de generación de las centrales termoeléctricas cubanas, relacionadas con la influencia estadística entre parámetros de proceso de la turbina, respecto al parámetro vibración absoluta, medidos en las chumaceras de la turbina. Se utilizan las bases de datos de los sistemas de monitoreado on-line de la turbina. Se exponen las relaciones existentes entre los principales parámetros seleccionados para este estudio.This work show the study in small steam turbine capacity of generation in cubans thermoelectric power station to relative with statistical influence between steam process parameters regarding absolute vibration parameter, in the steam housing measurements. Themselves use database as steam on-line monitoring systems. Expose the existing relation between the principal selection parameters for this study.

  4. Efficacy and safety of the pars plana clip in the Ahmed valve device inserted via the pars plana in patients with refractory glaucoma

    Directory of Open Access Journals (Sweden)

    Manuel Diaz-Llopis

    2010-05-01

    Full Text Available Manuel Diaz-Llopis1,2,3, David Salom1,3, Salvador García-Delpech1,2,3, Patricia Udaondo1,3, Jose Maria Millan3,5, J Fernando Arevalo61Department of Ophthalmology, La Fe University Hospital of Valencia, Valencia, Spain; 2Department of Ophthalmology of the Valencia University, Valencia, Spain; 3Biomedical Network Research Centre on Rare Diseases (CIBERER, Valencia, Spain; 4Catholic University San Vicente Martir, Valencia, Spain; 5Department of Genetics, La Fe University Hospital of Valencia, Valencia, Spain; 6Clinica Oftalmologica Centro Caracas, Retina and VItreous Service, Caracas, DC, VenezuelaPurpose: To evaluate the efficacy and safety of the pars plana clip (PPC in the Ahmed valve tube inserted via the pars plana in patients with secondary refractory glaucomas.Methods: Prospective and interventional case series that included 10 patients with secondary refractory glaucoma. The pars plana vitrectomy and the implant of the modified tube were performed during the same surgery. Control of intraocular pressure (IOP and the development of intra- and postoperative complications were evaluated during the follow-up.Results: Follow-up time was twelve months in all the patients. Control of IOP was achieved in 90% of patients, and 70% needed no antiglaucoma treatment. The complications that occurred were transient hypotony in three cases, choroidal detachment in two cases, and one case of intraocular hemorrhage. No case of tube extrusion or tube kink was observed.Conclusions: Our data suggests that implantation of the Ahmed tube modified with the PPC via the pars plana is safe and effective in patients with secondary refractory glaucomas. Keywords: pars plana clip, Ahmed valve, refractory glaucoma, pars plana vitrectomy

  5. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes.......Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...

  6. Images in medicine

    African Journals Online (AJOL)

    abp

    26 févr. 2013 ... baignent dans une prolifération musculaire lisse composée de faisceaux entrecroisés de cellules fusiformes régulières dépourvus d'atypie cytonucléaires ou de mitoses. Ces cellules se disposaient en manchons épais périvasculaires et étaient ailleurs dissociées par des zones fibreuses et par endroit ...

  7. Outcome of early pars plana vitrectomy in exogenous endophthalmitis

    International Nuclear Information System (INIS)

    Dar, A.J.; Islam, Q.U.; Hanif, M.K.

    2013-01-01

    Objective: To evaluate the role of early pars plana vitrectomy (PPV) in cases of exogenous endophthalmitis in terms of final visual outcome and to determine association between various study variables and final visual outcome. Study Design: Quasi experimental study. Place and Duration of Study: Armed Forces Institute of Ophthalmology (AFIO) Rawalpindi, from Aug 2010 to May 2012. Patients and Methods: Eleven cases of exogenous endophthalmitis (post surgical/post traumatic) were managed surgically through 20 G or 23/25 G complete and early PPV. Vitreous aspirate/explanted intraocular lens (IOL) were sent for culture and sensitivity in all cases. Intra and post operative complications were recorded and best corrected visual acuity (BCVA) at 3 months post operative interval was taken as final visual acuity. Results: Median age of study population was 55 years with male preponderance (64%). Approximately 2/3 rd of study population developed endophthalmitis within 6 weeks of surgery/trauma and 55% of patients were operated within 2 weeks of presentation. Positive culture from vitreous aspirate/IOL explant was obtained in 27% of cases. All the patients had initial BCVA in the range of counting finger (CF) at 2 meter to perception of light (PL+). However, 18% of the patients achieved final BCVA of 6/12 or better and 64% achieved final BCVA of 6/36 or better. Maculopathy (macular scar, macular pucker), corneal decompensation, corneal opacity and raised intraocular pressure were the major complications associated with compromised visual outcome. Conclusion: With the advancement in vitreoretinal surgical techniques and availability of more sophisticated viewing and illumination systems, early and complete vitrectomy for post operative or post traumatic endophthalmitis results in favorable visual outcome and early rehabilitation. (author)

  8. Intrinsic and integrative properties of substantia nigra pars reticulata neurons

    Science.gov (United States)

    Zhou, Fu-Ming; Lee, Christian R.

    2011-01-01

    The GABA projection neurons of the substantia nigra pars reticulata (SNr) are output neurons for the basal ganglia and thus critical for movement control. Their most striking neurophysiological feature is sustained, spontaneous high frequency spike firing. A fundamental question is: what are the key ion channels supporting the remarkable firing capability in these neurons? Recent studies indicate that these neurons express tonically active TRPC3 channels that conduct a Na-dependent inward current even at hyperpolarized membrane potentials. When the membrane potential reaches −60 mV, a voltage-gated persistent sodium current (INaP) starts to activate, further depolarizing the membrane potential. At or slightly below −50 mV, the large transient voltage-activated sodium current (INaT) starts to activate and eventually triggers the rapid rising phase of action potentials. SNr GABA neurons have a higher density of (INaT), contributing to the faster rise and larger amplitude of action potentials, compared with the slow-spiking dopamine neurons. INaT also recovers from inactivation more quickly in SNr GABA neurons than in nigral dopamine neurons. In SNr GABA neurons, the rising phase of the action potential triggers the activation of high-threshold, inactivation-resistant Kv3-like channels that can rapidly repolarize the membrane. These intrinsic ion channels provide SNr GABA neurons with the ability to fire spontaneous and sustained high frequency spikes. Additionally, robust GABA inputs from direct pathway medium spiny neurons in the striatum and GABA neurons in the globus pallidus may inhibit and silence SNr GABA neurons, whereas glutamate synaptic input from the subthalamic nucleus may induce burst firing in SNr GABA neurons. Thus, afferent GABA and glutamate synaptic inputs sculpt the tonic high frequency firing of SNr GABA neurons and the consequent inhibition of their targets into an integrated motor control signal that is further fine-tuned by neuromodulators

  9. PAR-1 and thrombin: the ties that bind the microenvironment to melanoma metastasis.

    Science.gov (United States)

    Zigler, Maya; Kamiya, Takafumi; Brantley, Emily C; Villares, Gabriel J; Bar-Eli, Menashe

    2011-11-01

    Progression of melanoma is dependent on cross-talk between tumor cells and the adjacent microenvironment. The thrombin receptor, protease-activated receptor-1 (PAR-1), plays a key role in exerting this function during melanoma progression. PAR-1 and its activating factors, which are expressed on tumor cells and the surrounding stroma, induce not only coagulation but also cell signaling, which promotes the metastatic phenotype. Several adhesion molecules, cytokines, growth factors, and proteases have recently been identified as downstream targets of PAR-1 and have been shown to modulate interactions between tumor cells and the microenvironment in the process of melanoma growth and metastasis. Inhibiting such interactions by targeting PAR-1 could potentially be a useful therapeutic modality for melanoma patients. ©2011 AACR.

  10. Application of passive auto catalytic recombiner (PAR) for BWR plants in Japan

    International Nuclear Information System (INIS)

    Kobayashi, K.; Murano, K.; Yamanari, S.; Yamamoto, Y.

    2001-01-01

    The passive auto-catalytic recombiner (PAR), which can recombine flammable gases such as hydrogen and oxygen with each other to avoid an explosion in case of a loss-of-coolant accident (LOCA), installed in the primary containment vessel does not require a power supply or dynamic equipment, while the existing flammability gas control system (FCS) of most BWRs as an outer loop of the primary containment vessel needs them to make flammable gases circulate through blowers and heaters in the system. PAR offers a number of advantages over existing FCS, such as high reliability, low cost due to much smaller amount of materials needed, good maintainability, good operability in case of a LOCA, and smaller space for installation. An experimental study has been carried out for the purpose of solving the problems of applying PAR to Japanese BWR plants instead of existing FCS, in which we grasped the basic characteristics of PAR. (author)

  11. ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

    Science.gov (United States)

    Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

    2016-02-15

    Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  12. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV; Gosselin, L; Qian, P

    2010-01-01

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum

  13. uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder

    DEFF Research Database (Denmark)

    Dohn, Line Hammer; Pappot, Helle; Iversen, Benedikte Richter

    2015-01-01

    The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling...... during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative...... or positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated...

  14. Contamination des eaux de puits traditionnels par les nitrates sur le ...

    African Journals Online (AJOL)

    SARAH

    30 juin 2014 ... Objectif : La contamination des eaux souterraines par les nitrates est un ... Methodology and Results: the origin of nitrate water from traditional wells of Lobo's watershed was ...... 12 water supply wells, Yucatan, Mexico.

  15. A Review of Radioactive Waste Disposal to the Ground at Hanford; Etude sur l'Elimination dans le Sol des Dechets Radioactifs a Hanford; 041e 0411 0417 0414 ; Evacuacion de Desechos Radiactivos en el Subsuelo de Hanford

    Energy Technology Data Exchange (ETDEWEB)

    Pearce, D. W.; Lindbroth, C. E.; Nelson, J. L.; Ames, Jr., L. L. [Hanford Laboratories, Hanford Atomic Products Operation, General Electric Company, Richland WA (United States)

    1960-07-01

    The disposal of radioactive wastes to the ground from the Hanford separations plants is summarized ; volumes of wastes and contained curies discharged to swamps, trenches, and cribs are presented. Significant literature on ion- exchange studies using Hanford soils is reviewed. A field experiment with a model crib is described; preliminary findings indicate that spreading a waste solution below a disposal facility may be of greater benefit in disposal operations than previously assumed. Further studies with the calcite-phosphate reaction are reported; significant variables which affect Sr{sup +2} removal are calcite surface area, pH of the influent, flow rate, temperature and phosphate ion concentration. Bone-seeking radioisotopes are also removed from F- solutions when contact is made with calcite. The zeolite clinoptilolite shows high selectivity for Cs{sup +} even in the presence of increased Na{sup +} concentration. The effect of the large-scale ground disposal operation at Hanford is described by means of a map and geological cross-sections showing areas and volumes of ground and ground water contamination. (author) [French] Les auteurs donnent un apercu de l'elimination dans le sol des dechets radioactifs des usines de separation des isotopes de Hanford ; ils indiquent les quantites de dechets - et de curies - qui sont evacuees dans des marecages, des tranchees et des coffres. Ils passent en revue des etudes importantes qui ont ete publiees sur les proprietes d'echangeurs d'ions des sols de Hanford. Ils decrivent une experience pratique faite avec un coffre modele; il ressort des resultats preliminaires que le fait de repandre une solution de dechets au-dessous d'une installation d'evacuation pourrait etre beaucoup plus avantageux pour les operations d'evacuation que l'on n'avait cru precedemment. Les auteurs signalent d'autres etudes fondees sur la reaction calcite-phosphate ; parmi les variables importantes qui influent sur l'elimination du Sr{sup ++}, il

  16. ParFit: A Python-Based Object-Oriented Program for Fitting Molecular Mechanics Parameters to ab Initio Data.

    Science.gov (United States)

    Zahariev, Federico; De Silva, Nuwan; Gordon, Mark S; Windus, Theresa L; Dick-Perez, Marilu

    2017-03-27

    A newly created object-oriented program for automating the process of fitting molecular-mechanics parameters to ab initio data, termed ParFit, is presented. ParFit uses a hybrid of deterministic and stochastic genetic algorithms. ParFit can simultaneously handle several molecular-mechanics parameters in multiple molecules and can also apply symmetric and antisymmetric constraints on the optimized parameters. The simultaneous handling of several molecules enhances the transferability of the fitted parameters. ParFit is written in Python, uses a rich set of standard and nonstandard Python libraries, and can be run in parallel on multicore computer systems. As an example, a series of phosphine oxides, important for metal extraction chemistry, are parametrized using ParFit. ParFit is in an open source program available for free on GitHub ( https://github.com/fzahari/ParFit ).

  17. Infection par le VIH chez les patientes atteintes de cancer du sein en ...

    African Journals Online (AJOL)

    L'objectif était de déterminer la prévalence de l'infection à VIH chez les patientes atteintes de cancer du sein et de comparer les caractéristiques anatomocliques et thérapeutiques de ces cancers du sein par rapports aux patientes non infectées par le VIH. Il s'agissait d'une étude rétrospective et analytique comparant les ...

  18. Molecular mechanism of bundle formation by the bacterial actin ParM

    Energy Technology Data Exchange (ETDEWEB)

    Popp, David, E-mail: dpopp@imcb.a-star.edu.sg [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore); Narita, Akihiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Iwasa, Mitsusada [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Maeda, Yuichiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Robinson, Robert C. [Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore)

    2010-01-22

    The actin homolog ParM plays a microtubule-like role in segregating DNA prior to bacterial cell division. Fluorescence and cryo-electron microscopy have shown that ParM forms filament bundles between separating DNA plasmids in vivo. Given the lack of ParM bundling proteins it remains unknown how ParM bundles form at the molecular level. Here we show using time-lapse TIRF microscopy, under in vitro molecular crowding conditions, that ParM-bundle formation consists of two distinct phases. At the onset of polymerization bundle thickness and shape are determined in the form of nuclei of short helically disordered filaments arranged in a liquid-like lattice. These nuclei then undergo an elongation phase whereby they rapidly increase in length. At steady state, ParM bundles fuse into one single large aggregate. This behavior had been predicted by theory but has not been observed for any other cytomotive biopolymer, including F-actin. We employed electron micrographs of ParM rafts, which are 2-D analogs of 3-D bundles, to identify the main molecular interfilament contacts within these suprastructures. The interface between filaments is similar for both parallel and anti-parallel orientations and the distribution of filament polarity is random within a bundle. We suggest that the interfilament interactions are not due to the interactions of specific residues but rather to long-range, counter ion mediated, electrostatic attractive forces. A randomly oriented bundle ensures that the assembly is rigid and that DNA may be captured with equal efficiency at both ends of the bundle via the ParR binding protein.

  19. Etude par simulation hil des performances d'un statcom pour la ...

    African Journals Online (AJOL)

    Ce travail présente l'étude par simulation Hardware In the Loop (HIL) des performances d'un STATCOM pour la stabilisation de la tension délivrée par une génératrice asynchrone triphasée auto excitée dans un réseau autonome. Nous avons combiné l'utilisation du logiciel de simulation LABVIEW et la carte ARDUINO ...

  20. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-06-01

    Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.

  1. Compression robuste du signal par la transformée avec les B ...

    African Journals Online (AJOL)

    Par contre, elle diminue de façon considérable pour les b-splincs et les paquets dbndelcttes de Haar. Du point de vue entropie, la compression par bfsplines est bonne que celle de la TCD. Nous donnons ci-dessous un tableau récapitulatif des résultats de quelques méthodes utilisées pour deux signaux EMG. Le facteur de ...

  2. SuPAR predicts postoperative complications and mortality in patients with asymptomatic aortic stenosis

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Eugen-Olsen, Jesper

    2018-01-01

    complications with a HR of 2.7 (95% CI 1.5 to 5.1, P=0.002), per doubling in suPAR. After adjusting for the European System for Cardiac Operative Risk Evaluation or Society of Thoracic Surgeons risk score, suPAR remained associated with postoperative mortality with a HR 3.2 (95% CI 1.2 to 8.6, P=0.025) and 2...

  3. Hep par-1: a novel immunohistochemical marker for differentiating hepatocellular carcinoma from metastatic carcinoma

    International Nuclear Information System (INIS)

    Hanif, R.

    2014-01-01

    To evaluate the diagnostic utility of Hep par-1 in differentiating hepatocellular carcinoma from metastatic carcinoma taking histopathology as a gold standard. Study Design: Comparative cross-sectional study. Place and Duration of Study: Pathology Department, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from April 2007 to February 2008. Methodology: Hep par-1 immunohistochemical stain was performed on 60 cases of liver carcinoma, 30 cases each of metastatic and hepatocellular carcinoma. Information regarding patient age, gender, sign and symptoms, radiographic findings, histological grade of tumour, and expression of Hep par-1 on hepatocellular and metastatic carcinoma were recorded on proforma sheet. Sensitivity, specificity, positive and negative predictive values, and accuracy of Hep par-1 were calculated using the formulas. Results: Hep par-1 expression was noted in 25 out of 30 cases of hepatocellular carcinoma (83%). Out of 30 cases of metastatic carcinoma, only one case expressed staining in < 5% tumour cells and remaining 29 cases showed no reactivity. The age of the patients with hepatocellular carcinoma ranged from 40 to 76 years with a median age of 60.5 years and 40 - 75 years for metastatic carcinomas with a median age of 57.5 years. Conclusion: Hep par-1 is a reliable immunohistochemical marker for cases of hepatocellular carcinoma (HCC). It can be used along with other markers in morphologically difficult cases when differential diagnosis lies between poorly differentiated HCC and metastatic carcinoma of liver. (author)

  4. Par and IR reflectance, transmittance, and absorptance of four crop canopies

    International Nuclear Information System (INIS)

    Wanjura, D.F.; Hatfield, J.L.

    1986-01-01

    Reflectance, transmittance and absorptance of electromagnetic radiation by cotton, soybeans, grain sorghum, and sunflower was measured at three growth stages in two wavebands (PAR: 0.4 to 0.7 pun and IR: 0.7 to 1.1 yim). As leaf area increased in each crop there were increases in IR reflectance and PAR absorptance and decreases in PAR reflectance and both PAR and IR transmittance. IR radiation was concentrated at the soil surface between rows by reflectance from the sides of canopies when crop cover was less than 80%. Across all crops one parameter, leaf overlap index, explained 81 and 71% of the PAR reflectance and another, crop cover, explained 86 and 94% of IR reflectance from rows and interrows, respectively. Attenuation of PAR radiation through the canopies of cotton and sunflower was similar (K = 0.62 and 0.67) but different from that of soybeans and grain sorghum (K = 0.46 and 0.43) which were the same

  5. Numerical analysis of the influence of PAR unit elevation within a vessel on its performance

    International Nuclear Information System (INIS)

    Kotouč, Miroslav

    2011-01-01

    On the basis of successful validation of the MELCOR code on several experiments from the international OECD/NEA programme THAI, a numerical parametric study has been conducted at NRI Řež evaluating the influence of PAR's vertical position within a vessel on its performance. Simulations were carried out for an Areva PAR unit which was considered to be placed at 5 different elevations in the THAI test vessel, the sixth simulation comprised a model of blower, simulating thus forced convection. The initial conditions were those of the THAI HR-12 test, which was characterized by steam-saturated atmosphere at elevated pressure and temperature. The results show that the overall hydrogen mass recombined monotonically decreases with PAR elevation. This behavior is due to hot, light and hydrogen-lean plume, coming out from the PAR outlet, which, due to buoyancy forces, eventually fills the upper part of the vessel and prevents thus the PAR unit from efficient operation (if the latter is placed near the top). It was also demonstrated that the effect of forced convection is favorable since it breaks the gas stratification and increases thus hydrogen concentration at the PAR inlet. (author)

  6. Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation

    International Nuclear Information System (INIS)

    Blanc-Brude, Olivier P.; Archer, Fabienne; Leoni, Patricia; Derian, Claudia; Bolsover, Steven; Laurent, Geoffrey J.; Chambers, Rachel C.

    2005-01-01

    Fibroblast proliferation and procollagen production are central features of tissue repair and fibrosis. In addition to its role in blood clotting, the coagulation cascade proteinase thrombin can contribute to tissue repair by stimulating fibroblasts via proteolytic activation of proteinase-activated receptor-1 (PAR 1 ). During hemostasis, the coagulation cascade proteinase factor X is converted into factor Xa. We have previously shown that factor Xa upregulates fibroblast proliferation via production of autocrine PDGF. In this study, we further examined the effects of factor Xa on fibroblast function and aimed to identify its signaling receptor. We showed that factor Xa stimulates procollagen promoter activity and protein production by human and mouse fibroblasts. This effect was independent of PDGF and thrombin production, but dependent on factor Xa proteolytic activity. We also showed that PAR 1 -deficient mouse fibroblasts did not upregulate procollagen production, mobilize cytosolic calcium, or proliferate in response to factor Xa. Desensitization techniques and PAR 1 -specific agonists and inhibitors were used to demonstrate that PAR 1 mediates factor Xa signaling in human fibroblasts. This is the first report that factor Xa stimulates extracellular matrix production. In contrast with endothelial cells and vascular smooth muscle cells, fibroblasts appear to be the only cell type in which the effects of factor Xa are mediated mainly via PAR 1 and not PAR 2 . These findings are critical for our understanding of tissue repair and fibrotic mechanisms, and for the design of novel approaches to inhibit the profibrotic effects of the coagulation cascade without compromising blood hemostasis

  7. Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphylococcus aureus bacteremia

    DEFF Research Database (Denmark)

    Mölkänen, T; Ruotsalainen, E; Thorball, C W

    2011-01-01

    The soluble form of urokinase-type plasminogen activator receptor (suPAR) is a new inflammatory marker. High suPAR levels have been shown to associate with mortality in cancer and in chronic infections like HIV and tuberculosis, but reports on the role of suPAR in acute bacteremic infections...... are scarce. To elucidate the role of suPAR in a common bacteremic infection, the serum suPAR levels in 59 patients with Staphylococcus aureus bacteremia (SAB) were measured using the suPARnostic ELISA assay and associations to 1-month mortality and with deep infection focus were analyzed. On day three, after...... the first positive blood culture for S. aureus, suPAR levels were higher in 19 fatalities (median 12.3; range 5.7-64.6 ng/mL) than in 40 survivors (median 8.4; range 3.7-17.6 ng/mL, p = 0.002). This difference persisted for 10 days. The presence of deep infection focus was not associated with elevated su...

  8. Brief communication: Population variation in human maxillary premolar accessory ridges (MxPAR).

    Science.gov (United States)

    Burnett, Scott E; Hawkey, Diane E; Turner, Christy G

    2010-02-01

    The purpose of this brief communication is to report the results of an analysis of maxillary premolar accessory ridges (MxPAR), a common but understudied accessory ridge that may occur both mesial and distal to the central ridge of the buccal cusp of upper premolars. We developed a new five-grade scoring plaque to better categorize MxPAR variation. Subsequently, we conducted a population analysis of MxPAR frequency in 749 dental casts of South African Indian, American Chinese, Alaskan Eskimo, Tohono O'odham (Papago), Akimel O'odham (Pima), Solomon Islander, South African Bantu, and both American and South African Whites. Northeast Asian and Asian-derived populations exhibited the highest MxPAR frequencies while Indo-European samples (South African Indians, American and South African Whites) exhibited relatively low frequencies. The Solomon Islanders and South African Bantu samples exhibited intermediate frequencies. Our analysis indicates that statistically significant differences in MxPAR frequency exist between major geographic populations. As a result, the MxPAR plaque has now been added to the Arizona State University Dental Anthropology System, an important contribution as maxillary premolar traits are underrepresented in analyses of dental morphology. 2009 Wiley-Liss, Inc.

  9. Examining relational empowerment for elementary school students in a yPAR program.

    Science.gov (United States)

    Langhout, Regina Day; Collins, Charles; Ellison, Erin Rose

    2014-06-01

    This paper joins relational empowerment, youth empowerment, and Bridging Multiple Worlds frameworks to examine forms of relational empowerment for children in two intermediary institutions-school and a youth participatory action research after-school program (yPAR ASP). Participants were twelve children, most of whom were Latina/o and from im/migrant families, enrolled in a yPAR ASP for 2 years. A mixed-method approach was utilized; we analyzed children's interviews, self-defined goals, and their social networks to examine their experiences of relational empowerment. We conclude that children experienced each of the five relational empowerment factors-collaborative competence, bridging social divisions, facilitating others' empowerment, mobilizing networks, and passing on a legacy-in the yPAR ASP setting, and some factors in school. These experiences, however, were more pronounced in the yPAR ASP setting. Additionally, social network analyses revealed that a small but meaningful percentage of actors bridged worlds, especially home and family, but by year 2, also school and the yPAR ASP. Finally, most helpers for school-based goals came from school, but a sizable number came from family, friends, and home worlds, and by year 2, also came from the yPAR ASP. Implications range from theoretical to methodological development, including the use of social network analysis as a tool to descriptively examine relational power in context.

  10. Calcination of Radioactive Waste in Molten Sulphur; Calcination de Dechets Radioactifs dans le Soufre Fondu; 041a 0410 041b 042c 0426 0418 041d 0418 0420 041e 0412 0410 041d 0418 0415 0420 0410 0414 0418 041e 0410 041a 0422 0418 0412 041d 042b 0425 041e 0422 0425 041e 0414 041e 0412 0412 0420 0410 0421 041f 041b 0410 0412 041b 0415 041d 041d 041e 0419 0421 0415 0420 0415 ; Calcinacion de Desechos Radiactivos en Azufre Fundido

    Energy Technology Data Exchange (ETDEWEB)

    Winsche, W. E.; Davis, Jr., M. W.; Goodlett, Jr., C. B.; Occhipinti, E. S.; Webster, D. S. [E.I. Du Pont de Nemours and Co., Aiken, SC (United States)

    1963-02-15

    . Leaching rates are calculated as, though there is complete removal of material from a surface layer. Rates of 10 to 20 mil/yr, or less, have been observed after an initial period of 6 to 8 weeks at moderately higher rates. (author) [French] Le Laboratoire de Savannah River met actuellement au point une methode nouvelle fondee sur les proprietes exceptionnelles du soufre qui permettent de transformer des dechets radioactifs en solides peu solubles, en vue de proceder a leur elimination definitive. Selon cette methode, on fait reagir les dechets liquides acides avec du soufre fondu a 150 Degree-Sign C: l'eau et les acides volatiles sont chasses, puis les composes chimiques presents dans les dechets sont calcines et/ou reduits chimiquement. La suspension soufre-dechets ainsi obtenue est alors chauffee pendant une duree de 1 a 5h aune temperature de 400 a 444 Degree-Sign C afin de chasser l'acide sulfurique et l'eau residuelle et de poursuivre la calcination et/ou la reduction des composes chimiques dans la suspension soufre-dechets. Au cour de ces operations, ie soufre fondu sert de milieu caloporteur, empeche l'entrainement des solides radioactifs dans la vapeur et les gaz de la reaction et previent la volatilisation du radioruthenium en empechant la formation du tetraoxyde. Des essais en laboratoire avec des dechets concentres de haute activite (1.3 x 10{sup 9} {gamma} c/(min)(ml), 2.0M Al(N0{sub 3}){sub 3}, et 1.5M HNO{sub 3}) ont montre qu'environ un cent-millieme seulement de l'activite presente dans la matiere premiere est emporte par le gaz qui se degage au cours de ces operations. Une fois termine le traitement a haute temperature, on laisse refroidir la suspension soufre-dechets jusqu'a 150 ou 120 Degree-Sign C et on la transvase ensuite dans le milieu d'isolement final, ou on la laisse se solidifier. Bien que les auteurs aient l'intention de proteger le milieu d'isolement contre l'action de l'eau, ils ont etudie la resistance de la suspension solidifiee soufre

  11. Parijs is een meervoud. Adriaan van Dis en de heruitvinding van de Hollander in Parijs

    NARCIS (Netherlands)

    Koffeman, M.N.; Koffeman, Maaike; Montoya, Alicia C.; Smeets, Marc

    2017-01-01

    Parijs, tot halverwege de 20ste eeuw het onbetwiste centrum van de Europese cultuur, heeft van oudsher een grote aantrekkingskracht uitgeoefend op Nederlandse kunstenaars en schrijvers. Velen van hen verbleven er kortere of langere tijd, op zoek naar internationale erkenning. De vrijere seksuele moraal

  12. Modeling post-wildfire hydrological processes with ParFlow

    Science.gov (United States)

    Escobar, I. S.; Lopez, S. R.; Kinoshita, A. M.

    2017-12-01

    Wildfires alter the natural processes within a watershed, such as surface runoff, evapotranspiration rates, and subsurface water storage. Post-fire hydrologic models are typically one-dimensional, empirically-based models or two-dimensional, conceptually-based models with lumped parameter distributions. These models are useful for modeling and predictions at the watershed outlet; however, do not provide detailed, distributed hydrologic processes at the point scale within the watershed. This research uses ParFlow, a three-dimensional, distributed hydrologic model to simulate post-fire hydrologic processes by representing the spatial and temporal variability of soil burn severity (via hydrophobicity) and vegetation recovery. Using this approach, we are able to evaluate the change in post-fire water components (surface flow, lateral flow, baseflow, and evapotranspiration). This work builds upon previous field and remote sensing analysis conducted for the 2003 Old Fire Burn in Devil Canyon, located in southern California (USA). This model is initially developed for a hillslope defined by a 500 m by 1000 m lateral extent. The subsurface reaches 12.4 m and is assigned a variable cell thickness to explicitly consider soil burn severity throughout the stages of recovery and vegetation regrowth. We consider four slope and eight hydrophobic layer configurations. Evapotranspiration is used as a proxy for vegetation regrowth and is represented by the satellite-based Simplified Surface Energy Balance (SSEBOP) product. The pre- and post-fire surface runoff, subsurface storage, and surface storage interactions are evaluated at the point scale. Results will be used as a basis for developing and fine-tuning a watershed-scale model. Long-term simulations will advance our understanding of post-fire hydrological partitioning between water balance components and the spatial variability of watershed processes, providing improved guidance for post-fire watershed management. In reference

  13. uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells.

    Science.gov (United States)

    Laurenzana, Anna; Chillà, Anastasia; Luciani, Cristina; Peppicelli, Silvia; Biagioni, Alessio; Bianchini, Francesca; Tenedini, Elena; Torre, Eugenio; Mocali, Alessandra; Calorini, Lido; Margheri, Francesca; Fibbi, Gabriella; Del Rosso, Mario

    2017-09-15

    In this manuscript, we show the involvement of the uPA/uPAR system in the regulation of aerobic glycolysis of melanoma cells. uPAR over-expression in human melanoma cells controls an invasive and glycolytic phenotype in normoxic conditions. uPAR down-regulation by siRNA or its uncoupling from integrins, and hence from integrin-linked tyrosine kinase receptors (IL-TKRs), by an antagonist peptide induced a striking inhibition of the PI3K/AKT/mTOR/HIF1α pathway, resulting into impairment of glucose uptake, decrease of several glycolytic enzymes and of PKM2, a checkpoint that controls metabolism of cancer cells. Further, binding of uPA to uPAR regulates expression of molecules that govern cell invasion, including extracellular matrix metallo-proteinases inducer (EMPPRIN) and enolase, a glycolytyc enzyme that also serves as a plasminogen receptor, thus providing a common denominator between tumor metabolism and phenotypic invasive features. Such effects depend on the α5β1-integrin-mediated uPAR connection with EGFR in melanoma cells with engagement of the PI3K-mTOR-HIFα pathway. HIF-1α trans-activates genes whose products mediate tumor invasion and glycolysis, thus providing the common denominator between melanoma metabolism and its invasive features. These findings unveil a unrecognized interaction between the invasion-related uPAR and IL-TKRs in the control of glycolysis and disclose a new pharmacological target (i.e., uPAR/IL-TKRs axis) for the therapy of melanoma. © 2017 UICC.

  14. Lumbar lordosis and pars interarticularis fractures: a case-control study

    International Nuclear Information System (INIS)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P.

    2012-01-01

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  15. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G; Lewis, Mark; Juette, Arne; Cahir, John G; Toms, Andoni P [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  16. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  17. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Science.gov (United States)

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily K.

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  18. RESOLUTION DU PROBLEME DE PREDICTION LINEAIRE PAR LA METHODE ULV. APPLICATION AU SIGNAL FID

    Directory of Open Access Journals (Sweden)

    M KHELIF

    2003-06-01

    Full Text Available Dans le cadre de la spectroscopie RMN, notre objectif est de déterminer le spectre d'absorption du signal de précession libre FID par la méthode de prédiction linéaire (PL. Ceci revient à résoudre le problème de prédiction linéaire en exploitant la méthode de corrélation par l'utilisation de la décomposition en valeurs singulières SVD pour l'inversion de la matrice de corrélation. Or, cette technique est la source d'un certain nombre de problèmes lorsque le signal est noyé dans du bruit. Aussi sera-t-elle coûteuse en temps lorsque les dimensions de la matrice de corrélation sont importantes. Afin de résoudre ce problème, nous exploitons les propriétés d'une nouvelle technique dérivée de la SVD, la décomposition ULV pour minimiser le coût du traitement et assurer une inversion correcte de la matrice de corrélation. Dans ce but, nous déterminons le spectre d'absorption par la technique ULV et nous le comparons avec le spectre déterminé par la SVD et  la FFT. Nous comparons par la suite la qualité des spectres obtenus par rapport au spectre d'absorption idéal  déterminé par FFT.

  19. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  20. CFD modelling of hydrogen stratification in enclosures: Model validation and application to PAR performance

    Energy Technology Data Exchange (ETDEWEB)

    Hoyes, J.R., E-mail: james.hoyes@hsl.gsi.gov.uk; Ivings, M.J.

    2016-12-15

    Highlights: • The ability of CFD to predict hydrogen stratification phenomena is investigated. • Contrary to expectation, simulations on tetrahedral meshes under-predict mixing. • Simulations on structured meshes give good agreement with experimental data. • CFD model used to investigate the effects of stratification on PAR performance. • Results show stratification can have a significant effect on PAR performance. - Abstract: Computational Fluid Dynamics (CFD) models are maturing into useful tools for supporting safety analyses. This paper investigates the capabilities of CFD models for predicting hydrogen stratification in a containment vessel using data from the NEA/OECD SETH2 MISTRA experiments. Further simulations are then carried out to illustrate the qualitative effects of hydrogen stratification on the performance of Passive Autocatalytic Recombiner (PAR) units. The MISTRA experiments have well-defined initial and boundary conditions which makes them well suited for use in a validation study. Results are presented for the sensitivity to mesh resolution and mesh type. Whilst the predictions are shown to be largely insensitive to the mesh resolution they are surprisingly sensitive to the mesh type. In particular, tetrahedral meshes are found to induce small unphysical convection currents that result in molecular diffusion and turbulent mixing being under-predicted. This behaviour is not unique to the CFD model used here (ANSYS CFX) and furthermore, it may affect simulations run on other non-aligned meshes (meshes that are not aligned perpendicular to gravity), including non-aligned structured meshes. Following existing best practice guidelines can help to identify potential unphysical predictions, but as an additional precaution consideration should be given to using gravity-aligned meshes for modelling stratified flows. CFD simulations of hydrogen recombination in the Becker Technologies THAI facility are presented with high and low PAR positions

  1. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

    Directory of Open Access Journals (Sweden)

    Laura P Bernard

    Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.

  2. Increased plasma soluble uPAR level is a risk marker of respiratory cancer in initially cancer-free individuals

    DEFF Research Database (Denmark)

    Langkilde, Anne A; Hansen, Tine Willum; Ladelund, Steen

    2011-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a stable plasma biomarker associated with inflammation and disease. This study tested the association between suPAR levels and incident respiratory, gastrointestinal or other types of cancer in initially cancer-free individuals...... with respiratory, gastrointestinal and other cancer types, respectively.CONCLUSIONS: Elevated suPAR levels were associated with increased risk of incident respiratory cancer and other types of cancer, but not gastrointestinal cancers, independently of established risk factors, CRP and leukocyte numbers. Impact.......RESULTS: suPAR levels ranged from 0.6-22 ng/ml, and median suPAR level was 4.01 ng/ml. 1 ng/ml increase in baseline suPAR was associated with adjusted hazard ratios (HR) of 1.61 (95% CI: 1.23-2.11, P

  3. Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.

    Directory of Open Access Journals (Sweden)

    Kara R Barber

    2017-02-01

    Full Text Available Disruption of synapses underlies a plethora of neurodevelopmental and neurodegenerative disease. Presynaptic specialization called the active zone plays a critical role in the communication with postsynaptic neuron. While the role of many proteins at the active zones in synaptic communication is relatively well studied, very little is known about how these proteins are transported to the synapses. For example, are there distinct mechanisms for the transport of active zone components or are they all transported in the same transport vesicle? Is active zone protein transport regulated? In this report we show that overexpression of Par-1/MARK kinase, a protein whose misregulation has been implicated in Autism spectrum disorders (ASDs and neurodegenerative disorders, lead to a specific block in the transport of an active zone protein component- Bruchpilot at Drosophila neuromuscular junctions. Consistent with a block in axonal transport, we find a decrease in number of active zones and reduced neurotransmission in flies overexpressing Par-1 kinase. Interestingly, we find that Par-1 acts independently of Tau-one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau. Thus, our study strongly suggests that there are distinct mechanisms that transport components of active zones and that they are tightly regulated.

  4. Removal of focal segmental glomerulosclerosis (FSGS) factor suPAR using CytoSorb.

    Science.gov (United States)

    Schenk, Heiko; Müller-Deile, Janina; Schmitt, Roland; Bräsen, Jan Hinrich; Haller, Hermann; Schiffer, Mario

    2017-12-01

    Treatment of primary focal segmental glomerulosclerosis (FSGS) and its recurrence after kidney transplantation associated with rapid deterioration of kidney function remains to be challenging despite advances in immunosuppressive therapy. The presence of circulating factors has been postulated to be a pivotal player in the pathogenesis of FSGS, although suPAR and CLCF-1 have been identified as the most promising causative factors. The potential therapeutic effect of suPAR elimination in an FSGS patient using CytoSorb, a hemoadsorption device that gained attention in the cytokine elimination in septic patients, was studied. Efficiency of total plasma exchange to remove suPAR was determined. CytoSorb hemoadsorption caused a 27.33% reduction of the suPAR level in a single treatment, whereas total plasma exchange showed a suPAR level reduction of 25.12% (n = 3; 95% confidence interval, 0.2777-0.8090; P < 0.01), which may indicate therapeutic potential in the treatment of primary FSGS and its recurrence in a kidney transplant. © 2017 Wiley Periodicals, Inc.

  5. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    International Nuclear Information System (INIS)

    Bache, Michael; Bosco, Filippo G; Brøgger, Anna L; Frøhling, Kasper B; Boisen, Anja; Alstrøm, Tommy Sonne; Hwu, En-Te; Chen, Ching-Hsiu; Hwang, Ing-Shouh; Eugen-Olsen, Jesper

    2013-01-01

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody–antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform. (paper)

  6. PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease.

    Science.gov (United States)

    Ray, Tanusree; Pal, Amit

    2016-05-01

    Bacterial toxins have emerged as promising agents in cancer treatment strategy. Hemagglutinin (HAP) protease secreted by Vibrio cholerae induced apoptosis in breast cancer cells and regresses tumor growth in mice model. The success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity for normal tissues. Increased expression of Protease Activated Receptor-1 (PAR-1) has been reported in different malignant cells. In this study we report that HAP induced activation and over expression of PAR-1 in breast cancer cells (EAC). Immunoprecipitation studies have shown that HAP specifically binds with PAR-1. HAP mediated activation of PAR-1 caused nuclear translocation of p50-p65 and the phosphorylation of p38 which triggered the activation of NFκB and MAP kinase signaling pathways. These signaling pathways enhanced the cellular ROS level in malignant cells that induced the intrinsic pathway of cell apoptosis. PAR-1 mediated apoptosis by HAP of malignant breast cells without effecting normal healthy cells in the same environment makes it a good therapeutic agent for treatment of cancer.

  7. "It was like reading a detective novel": Using PAR to work together for culture change.

    Science.gov (United States)

    Fortune, Darla; McKeown, Janet; Dupuis, Sherry; de Witt, Lorna

    2015-08-01

    Participatory action research (PAR), with its focus on engagement and collaboration, is uniquely suited to enhancing culture change initiatives in dementia care. Yet, there is limited literature of its application to culture change approaches in care settings, and even less in dementia specific care contexts. To address these gaps in the literature, the purpose of this paper is to examine the complexities of a PAR project aimed at changing the culture of dementia care in two diverse dementia care settings, including a long term care (LTC) and community care setting. Drawing from data gathered throughout the PAR process, we unpack the challenges experienced by participants working together to guide culture change within their respective care settings. These challenges include: overextending selves through culture change participation; fluctuating group membership; feeling uncertainty, confusion and apprehension about the process; frustratingly slow process; and seeking diverse group representation in decision making. We also highlight the potential for appreciative inquiry (AI) to be integrated with PAR to guide a process whereby participants involved in culture change initiatives can develop strategies to mitigate challenges they experience. We view the challenges and strategies shared here as being constructive to would-be culture change agents and hope this paper will move others to consider the use of PAR when engaging in culture change initiatives. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

    Science.gov (United States)

    Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

    2011-01-01

    Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963

  9. The use of radiotracer techniques to study lubrication and wear in large diesel engines; Emploi des indicateurs radioactifs pour l'etude de la lubrification et de l'usure dans les moteurs diesel de grande puissance; Ispol'zovanie metodov radioaktivnykh indikatorov dlya izucheniya smazki i iznosa bol'shikh dizel'nykh motorov; Aplicacion de los indicadores radiactivos al estudio de la lubricacion y desgaste de los motores diesel de gran potencia

    Energy Technology Data Exchange (ETDEWEB)

    Howes, Jr, J E; Braun, W J; Sunderman, D N [Battelle Memorial Institute, Columbus, OH (United States)

    1962-01-15

    Radiotracer techniques have been applied to the study of lubrication and wear in large diesel engines on a scale not before considered practical, with perfect safety and with unique technological results. Both lubricating-oil consumption and cylinderliner wear have been evaluated as a function of operating conditions on diesel engines in the 1000 HP range. Techniques were developed for tapping 200 gal (US) of lubricating oil with 60 mc of zinc-65 and determining oil consumption by sampling exhaust gas during operation under a variety of conditions. Measurement of the rate of lubeoil consumption could be made in 10 min rather than the 24 to 48 h previously required. Irradiation techniques were developed for neutron activation of the lower cylinder portion of a 48-in long, 8-in diam. cylinder liner. Suitable thermal-neutron shielding allowed production of 300-d manganese-54 which resulted in extending the useful life of the liner for wear studies by a factor of six to eight over that of a comparable liner thermally activated to produce iron-59. The fact that studies with such large quantities of radioactive material can be carried out in standard research facilities in the diesel engine field opens an entirely new area to tracer applications. Selective activation and judicious use of thermalneutron shielding increases the versatility of the tracer technique in localizing measurement to areas of interest, reducing the total quantity of radioactive material required in wear studies of large parts, and facilitating simultaneous wear-measurement on engine parts of identical chemical composition. (author) [French] On s'est servi d'indicateurs radioactifs pour l'etude de la lubrification et de l'usure des moteurs diesel de grande puissance, et cela a une echelle qui jusqu'a present n'etait pas consideree comme pratiquement realisable, avec m e securite parfaite et des resultats technologiques sans precedent. La consommation de l'huile de graissage et l'usure des chemises

  10. mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer.

    Science.gov (United States)

    Hau, Andrew M; Leivo, Mariah Z; Gilder, Andrew S; Hu, Jing-Jing; Gonias, Steven L; Hansel, Donna E

    2017-01-01

    Mammalian target of rapamycin complex 2 (mTORC2) has been identified as a major regulator of bladder cancer cell migration and invasion. Upstream pathways that mediate mTORC2 activation remain poorly defined. Urokinase-type plasminogen activator receptor (uPAR) is a GPI-anchored membrane protein and known activator of cell-signaling. We identified increased uPAR expression in 94% of invasive human bladder cancers and in 54-71% of non-invasive bladder cancers, depending on grade. Normal urothelium was uPAR-immunonegative. Analysis of publicly available datasets identified uPAR gene amplification or mRNA upregulation in a subset of bladder cancer patients with reduced overall survival. Using biochemical approaches, we showed that uPAR activates mTORC2 in bladder cancer cells. Highly invasive bladder cancer cell lines, including T24, J82 and UM-UC-3 cells, showed increased uPAR mRNA expression and protein levels compared with the less aggressive cell lines, UROtsa and RT4. uPAR gene-silencing significantly reduced phosphorylation of Serine-473 in Akt, an mTORC2 target. uPAR gene-silencing also reduced bladder cancer cell migration and Matrigel invasion. S473 phosphorylation was observed by immunohistochemistry in human bladder cancers only when the tumors expressed high levels of uPAR. S473 phosphorylation was not controlled by uPAR in bladder cancer cell lines that are PTEN-negative; however, this result probably did not reflect altered mTORC2 regulation. Instead, PTEN deficiency de-repressed alternative kinases that phosphorylate S473. Our results suggest that uPAR and mTORC2 are components of a single cell-signaling pathway. Targeting uPAR or mTORC2 may be beneficial in patients with bladder cancer. Copyright © 2016. Published by Elsevier Inc.

  11. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes

    Science.gov (United States)

    Magnussen, Synnøve; Hadler-Olsen, Elin; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja E.; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg

    2014-01-01

    Background The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells’ expression level of uPAR affected the activity of gelatinolytic enzymes. Methods The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM) proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography. Results We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes. Conclusions Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the

  12. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  13. Paraplégie compliquant une plaie abdominale antérieure par arme blanche

    Science.gov (United States)

    Elahmadi, Brahim; Awab, Almahdi; El Moussaoui, Rachid; El Hijri, Ahmed; Azzouzi, Abderrahim; Alilou, Mustapha

    2015-01-01

    Les traumatismes médullaires sont des complications rares des plaies abdominales antérieures par arme blanche. Son diagnostic est difficile parfois retardé. L'imagerie par résonance magnétique reste l'examen de choix. Le traitement dépend du tableau clinique et de la gravité de la souffrance médullaire. Le pronostic est corrélé à l’étendue et à la nature de la lésion médullaire. Nous rapportons un cas exceptionnel d'un traumatisme médullaire chez une patiente victime d'une plaie abdominale antérieure par arme blanche. PMID:25995808

  14. Evaluation of Passive Autocatalytic Recombiner (PAR) Implementation in a Konvoi NPP Containment Type

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Alonso, E.; Papini, D.; Jimenez, G.

    2015-07-01

    The evaluation of Passive Autocatalytic Recombiner (PAR) implementation has been developed under the methodology extracted from the IAEA document, analysing the size, location and number of the PARs capable to minimize the combustion risk, which arises from a hydrogen release generated during a severe accident and its distribution in containment building. A detailed three-dimensional model of Konvoi (PWR) containment with GOTHIC 8.1 code was used for the simulations. The hydrogen preferential pathways and the accumulation points were studied and identified on the basis of a base case scenario without any mitigation measure. The PAR configuration offers an improvement in the chosen accidental scenario; decreasing the possibility of hydrogen combustion and leading to concentration values below the flammability limit (hydrogen concentration below 7%), in all the containment compartments at the end of the transient. Furthermore, from the analysis, it is concluded that the time required to reach hydrogen concentrations below the combustion limit is considerably reduced. (Author)

  15. CRP and suPAR are differently related to anthropometry and subclinical organ damage

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L

    2013-01-01

    BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects...... of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI......) (P3: 1.31 (1.16-1.47), whereas log-CRP was not (1.00 (0.89-1.11))). CONCLUSIONS: CRP is positively associated with anthropometric measures, whereas suPAR is linked to endothelial dysfunction and atherosclerosis....

  16. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-08-01

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects

  17. Harmonization and development of resources and tools for Italian natural language processing within the PARLI project

    CERN Document Server

    Bosco, Cristina; Delmonte, Rodolfo; Moschitti, Alessandro; Simi, Maria

    2015-01-01

    The papers collected in this volume are selected as a sample of the progress in Natural Language Processing (NLP) performed within the Italian NLP community and especially attested by the PARLI project. PARLI (Portale per l’Accesso alle Risorse in Lingua Italiana) is a project partially funded by the Ministero Italiano per l’Università e la Ricerca (PRIN 2008) from 2008 to 2012 for monitoring and fostering the harmonic growth and coordination of the activities of Italian NLP. It was proposed by various teams of researchers working in Italian universities and research institutions. According to the spirit of the PARLI project, most of the resources and tools created within the project and here described are freely distributed and they did not terminate their life at the end of the project itself, hoping they could be a key factor in future development of computational linguistics.

  18. Effect of a physical activity intervention on suPAR levels

    DEFF Research Database (Denmark)

    Rohde, Christopher; Polcwiartek, Christoffer; Andersen, Eivind

    2018-01-01

    OBJECTIVES: Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel inflammatory marker, associated with lifestyle diseases and mortality risk. No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design. DESIGN AND METHODS......: suPAR and C-reactive protein (CRP) levels were determined in blood samples from a previous randomized controlled trial with Pakistani immigrants in Norway, 2008. The study included physically inactive men that were randomized to an intervention group (supervised group exercises) or a control group...... and followed for 5 months. A linear regression model was used and adjusted for age, inactivity level at baseline, and mean difference in CRP levels. RESULTS: Overall, 80 and 53 participants were included in the intervention and control group, respectively. Obesity and smoking were associated with higher su...

  19. Accouchement par césarienne et mortalité maternelle du postpartum

    OpenAIRE

    Deneux-Tharaux , Catherine; Carmona , Elodie; Bouvier-Colle , Marie-Hélène; Bréart , Gérard

    2006-01-01

    Objectifs Une augmentation continue du taux d'accouchements par césarienne (CS)est observée dans la plupart des pays depuis 20 ans. Cette évolution a suscité l'émergence d'un débat controversé sur les risques et les bénéfices associés à la CS. L'objectif de cette étude était d'estimer le risque de mort maternelle du postpartum lié directement à la CS par comparaison à l'accouchement par voie basse, globalement et en distinguant les CS pre- ou intra- partum . Méthode Etude cas/témoins. Les cas...

  20. Modification de la surface du cuivre par implantation ionique par source plasma (IISP): applications à l’érosion cathodique dans les systèmes à arcs

    OpenAIRE

    Roy, F

    2006-01-01

    L’érosion cathodique est un phénomène bien connu qui limite la durée de vie de l’électrode négative dans les systèmes à arcs. Dans le présent mémoire, nous avons tenté de voir si la formation de précipités nanométriques d’oxyde de cuivre pouvait réduire l’érosion cathodique nécessaire au maintien de l’arc en mode thermo-champ (T-F). Les dits précipités ont été produits par implantation ionique par source plasma (IISP). Avec l’aide de techniques de caractérisation telle que la microscopie à fo...

  1. Intermediate energy neutron fast chopper associated to the pile EL3; Spectrometre mecanique rapide pour neutrons intermediaires associe a la pile EL3

    Energy Technology Data Exchange (ETDEWEB)

    Julien, J; Netter, F; Martin, R; Rouge, P [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires; Arditti, R; Chaffiotte, P [S.E.M. Hispano-Suisa (France)

    1958-07-01

    The apparatus is a fast chopper placed on a beam issued from the tank of the pile EL3. It is composed of a steel rotor with a rigid vertical axis and eight pairs of slits in the maximum cross-section plane (diameter 48 cm). The originality of the apparatus consists mainly in the driving system by oil turbine, whiclows a more reliable and versatile operation. The spectrometer is running regularly at 15000 r.p.m. In the conditions, the slits (precision of cutting: {+-} 5 microns) release neutron beams with time half-width equal to 1/4 micro-second. Therefore, with a 20 meter flight-path, the resolution power of the fast chopper is about 10 milli-microsecond/metre. All the safety devices are provided to ensure a steady running, without permanent control. The speed of rotation is stabilized to better than {+-} 1/1000 in all the rate range between 6 000 and 15 500 r.p.m. A lead device for moving in and out the sample allows to work with radioactive samples. The apparatus is connected to a hundred 1/4 microsecond channel time-of-flight selector. A thousand channel selector with magnetic memory (Argonne type) will be ready in a few months. (author)Fren. [French] L'appareil est un spectrometre mecanique rapide dispose sur un des faisceaux sortant de la cuve de la pile EL3. Il comprend un rotor d'acier a axe vertical rigide avec huit paires de fentes disposees dans le plan de section maximum (diametre 40 cm). L'originalite de l'appareil tient surtout dans le systeme d'entrainement par turbine a huile, qui assure une grande securite et une grande souplesse de fonctionnement. Le spectrometre tourne a 15000 tours/mn de fa n reguliere. Dans ces conditions, les fentes (executees a {+-} 5 microns pres liberent des faisceaux de neutrons avec une largeur a mi-hauteur en temps de 1/4 de microseconde. Avec une base de parcours de 20 m, le pouvoir de resolution du spectrometre mecanique est donc voisin de 10 millimicroseconde/metre. Tous les dispositifs de securite sont prevus pour

  2. Comparison of Direct Pars Repair Techniques of Spondylolysis in Pediatric and Adolescent Patients: Pars Compression Screw Versus Pedicle Screw-Rod-Hook.

    Science.gov (United States)

    Karatas, Ali F; Dede, Ozgur; Atanda, Alfred A; Holmes, Larry; Rogers, Kenneth; Gabos, Peter; Shah, Suken A

    2016-08-01

    Retrospective clinical cohort study. To compare the clinical and radiographic outcomes of patients who were treated with intrasegmental pars fixation by either laminar compression screw (LS) or a pedicle screw, rod, and laminar hook (PSRH) construct. Spondylolysis is a nonunion defect of the pars interarticularis. In symptomatic spondylolysis, direct repair of the pars interarticularis defect can preserve motion and prevent abnormal stresses at the adjacent levels. Sixteen patients who failed nonoperative treatment and underwent direct pars repair by using LS (n=9) or PSRH (n=7) constructs were included in the study. Clinical outcome was assessed by using the MacNab criteria. Radiologic fusion and complications were evaluated using plain radiographs or computed tomography images and patient charts. The healing rate was 100% after 6 months. The healing time was similar in both the groups: LS, 6.5 months; PSRH, 6.2 months. Patients with PSRH (5.9 mo) were more likely to return to sports earlier relative to patients with LS (7.7 mo). There were no complications in the LS group; in the PSRH group, 1 patient had mild sensory deficit and 2 had superficial wound infections. The MacNab criteria for pain assessment showed an excellent or good outcome in 8 of 9 patients in LS group and 6 of 7 patients in PSRH group. Relative to LS patients, there was a significant increase in surgical time and estimated blood loss among PSRH patients. Either of the mentioned 2 techniques appears to produce acceptable results. Biplanar fluoroscopy and navigation systems could minimize the risk of screw misplacement with LS construct. Familiarity with the various fixation techniques will allow the surgeon to select the most appropriate surgical technique.

  3. First-in-human uPAR PET: Imaging of Cancer Aggressiveness

    Science.gov (United States)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene; Christensen, Camilla; Madsen, Jacob; Nielsen, Carsten H.; Thurison, Tine; Klausen, Thomas Levin; Holm, Søren; Loft, Annika; Berthelsen, Anne Kiil; Ploug, Michael; Pappot, Helle; Brasso, Klaus; Kroman, Niels; Højgaard, Liselotte; Kjaer, Andreas

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with 64Cu for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of 64Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment with laboratory blood screening tests was performed before and after PET ligand injection. In a subgroup of the patients, the in vivo stability of our targeted PET ligand was determined in collected blood and urine. No adverse or clinically detectable side effects in any of the 10 patients were found. The ligand exhibited good in vivo stability and fast clearance from plasma and tissue compartments by renal excretion. In addition, high uptake in both primary tumor lesions and lymph node metastases was seen and paralleled high uPAR expression in excised tumor tissue. Overall, this first-in-human study therefore provides promising evidence for safe use of 64Cu-DOTA-AE105 for uPAR PET imaging in cancer patients. PMID:26516369

  4. Sucralfate modulates uPAR and EGFR expression in an experimental rat model of cervicitis.

    Science.gov (United States)

    Mannari, C; Santi, S; Migliori, M; Filippi, C; Origlia, N; Sansò, M; Boldrini, E; Giovannini, L

    2008-01-01

    Sucralfate is a drug used in the treatment of gastric and duodenal ulcer; it is cytoprotective and able to increase the bioavailability of several growth factors, modulating the wound healing process. In this study we tested the possible therapeutic effect of Sucralfate in the treatment of ulcerative lesions occurring in uterine cervix; to investigate such effect we used an experimental rat model of cervicitis in which the uPAR and EGFR expression were evaluated. Cervicitis was induced in wild and ovariectomized Wistar female rats by an acetic acid-soaked tampon. The animals were divided into two main groups (4 and 7 days) and Sucralfate was administered topically until the day they were sacrificed. In order to distinguish physiological and drug-induced healing, quantitative and qualitative uPAR and EGFR expression were evaluated by using Western blot and Immunohistochemistry techniques. Western blot analysis demonstrated an increased expression of both receptors after 4 days from wounding in wild and ovariectomized animals. In particular in ovariectomized animals the expression of uPAR and EGFR increased after 4 days while it reduced following the administration of Sucralfate. In wild rats the same was observed for uPAR expression, while EGFR was different; in fact, its expression increased significantly at day 4 in the animals treated with the drug and only at day 7 in those untreated. Immunohistochemistry highlighted a noteworthy epithelial colocalization of EGFR and uPAR after 4 days in the animals treated with Sucralfate. We conclude that Sucralfate can promote the healing of ulcerative cervicitis and moreover, it reduces the normal healing time because of its modulatory property on uPAR and EGFR expression.

  5. Protease activated receptors (PARS) mediation in gyroxin biological activity; Mediacao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose Alberto Alves da

    2009-07-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH{sub 2}, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  6. Rat beta-LPH, gamma-LPH and beta-endorphin biosynthesized by isolated cells of pars intermedia and pars distalis

    International Nuclear Information System (INIS)

    Gianoulakis, C.; Seidah, N.G.; Routhier, R.; Chretien, M.

    1980-01-01

    Rats pars intermedia cells were incubated for 3 h with the following amino-acids: a) 35 S-methionine and 3 H-phenylalamine; b) 3 H-valine; and c) 3 H-valine and 3 H-lysine. Radioactive gamma-lipotropin, beta-lipotropin and beta-endorphin were purified on carboxy- methyl-cellulose and characterized by polyacrylamide disc gel electrophoresis af pH 4.5, molecular weight estimation and microsequencing. Rat gamma-lipotropin was shown to differ slightly from ovine gamma-lipotropin in its NH 2 -terminal amino acid sequence, in containing no methionine and having phenylalanine at position 6, valine at positions 13 and 27, and lysine at position 20. The same variations were observed in the sequence of rat beta-lipotropin, while rat beta-endorphin was shown to be identical to the ovine beta-endorphin. Following a 3-h pulse of rat pars distalis, the cells were extracted with care to avoid beta-lipotropin degradation by proteolytic enzymes. A peptide was purified and identified to be rat beta-endorphin, thus demonstrating that beta-endorphin is biosynthesized in pars distalis and is not an extraction artifact. (author)

  7. Eficacia de los antivirales en la parálisis de Bell

    OpenAIRE

    Vázquez, María Cristina; Sánchez, Nury; Calvo, Judith; Perna, Abayubá

    2008-01-01

    Introducción: la parálisis de Bell es una afección frecuente que presenta en 15% de los casos una recuperación incompleta. En los últimos años se ha acumulado evidencia del posible rol del virus herpes simple tipo 1 en su etiología. Objetivos: comparar la eficacia de valaciclovir y prednisona versus prednisona placebo en la parálisis de Bell. Material y método: se realizó un ensayo prospectivo, randomizado y placebo controlado. De los 41 pacientes incluidos, 21 fueron tratados con valaciclovi...

  8. evaluation de la fertilite femelle des arabusta par le niveau de ...

    African Journals Online (AJOL)

    Les hybrides Arabusta sont caractérisés par une faible fertilité exprimée par des taux de caracolis élevés et des taux de loges vides importants induisant des productivités faibles. Pour une stratégie plus efficiente des sélections, il est important de connaître les niveaux de fertilité femelle des différents types de caféiers ...

  9. Densité, morphologie urbaine et qualité de vie. Une approche par le projet

    OpenAIRE

    Occhiuto, Rita; Goossens, Marc; Fisher, Axel

    2013-01-01

    La recherche "Densification des tissus urbanisés en Wallonie: forme, acceptabilité et modalités pour accompagner la mutation des tissus bâtis" s'articule en plusieurs volets thématiques, parmi lesquels figure le volet "formes urbaines, modes d'habitat". Ce dernier volet est abordé selon deux approches parallèles et complémentaires qui se valident mutuellement: la première dite "par le projet" (approche qualitative et opérationnelle) et la seconde par analyse statistique et cartographique (ap...

  10. Situation des personnes transgenres par rapport au VIH/IST en Suisse : rapid assessment

    OpenAIRE

    Bize, R.; Koutaissoff, D.; Dubois-Arber, F.

    2013-01-01

    Ce rapport permet d'identifier le sous-groupe des personnes transgenres pratiquant ou ayant pratiqué le travail du sexe comme une population clairement exposée à un risque notoirement élevé d'infection par le VIH et les IST. L'ampleur rapportée du phénomène justifie pleinement l'inclusion de cette population dans le dispositif de surveillance comportementale du VIH et des autres IST, mais également la réalisation urgente d'actions de prévention communautaire. Par contre, il ne nous permet pas...

  11. Disposal of Radioactive Waste in the Subsurface of the Federal Republic of Germany: Geological and Hydro-Geological Problems; Elimination des Dechets Radioactifs dans le Sous-Sol de la Republique Federale d'Allemagne: Problemes Geologiques et Hydrogeologiques; 041f 041e 0414 ; Evacuacion de Desechos Radiactivos en el Subsuelo de la Republica Federal de Alemania Problemas Geologicos e Hidrogeologicos

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, R.; Richter, W. [Bundesanstalt fuer Bodenforschung, Hannover (Germany)

    1960-07-01

    The geological and hydrogeological problems related to the subsurface disposal of radioactive wastes in the Federal Republic of Germany are outlined. Special consideration is given to the possibility of storing solid and liquid wastes in the salt-domes widespread in the north-west, and of injecting liquid waste into deep reservoirs containing briny water and located in favourable geologic structures. (author) [French] Les auteurs decrivent les problemes geologiques et hydrogeologiques que pose, dans la Republique federale d'Allemagne, l'elimination des dechets radioactifs dans le sous-sol. Ils examinent notamment la possibilite d'emmagasiner des dechets solides et liquides dans les salines, qui abondent dans la partie nord-ouest et d'injecter des dechets liquides dans de profonds reservoirs d'eau saline, situes dans des formations geologiques presentant des conditions favorables. (author) [Spanish] Los autores exponen los problemas geologicos e hidrogeologicos que plantea la evacuacion de desechos radiactivos en el subsuelo de la Republica Federal de Alemania. Examinan sobre todo la posibilidad de almacenar desechos solidos y liquidos en los domos de sal, muy abundantes en el noroeste del pais, y de inyectar desechos liquidos en depositos profundos de agua salobre situados en estructuras geologicas que presentan condiciones favorables. (author) [Russian] Privoditsja opisanie geologicheskih i gidrogeologicheskih problem, svjazannyh s podzemnym udaleniem radioaktivnyh othodov v Federal'noj Respublike Germanii. Osoboe vnimanie udeljaetsja vozmozhnosti skladirovanija tverdyh i zhidkih othodov v soljanyh kupolah, imejushhihsja v bol'shom kolichestve v severo- zapadnoj chasti Germanii, i zahoronenija zhidkih othodov v glubokie rezervuary, soderzhashhie solenye vody i raspolozhennye v podhodjashhih geologicheskih strukturah. (author)

  12. Experimental study about the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin

    Directory of Open Access Journals (Sweden)

    Hui-Lin Mao

    2017-11-01

    Full Text Available Objective: To study the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin. Methods: Nephroblastoma SK-NEP-1 cells were cultured and divided into four groups, control group were treated with RMPI-1640 without serum or drugs, cisplatin group were treated with serum-free RMPI-1640 containing 5 μg/mL cisplatin, Par-4 group were transfected by Par-4 overexpression plasmids with serum-free RMPI-1640, and cisplatin + Par-4 group were transfected by Par-4 overexpression plasmid with serum-free RMPI-1640 containing 5 μg/mL cisplatin. The cell proliferation activity as well the expression of apoptosis genes, migration genes and invasion genes was measured. Results: 8 h, 16 h and 24 h after different conditions of treatment, the cell proliferation activity of cisplatin group, Par-4 group and cisplatin + Par-4 group were significantly lower than that of control group, and the cell proliferation activity of cisplatin + Par-4 group was significantly lower than that of cisplatin group and Par-4 group; 24 h after different conditions of treatment, Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin group, Par-4 group and cisplatin + Par-4 group were greatly higher than those in control group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly lower than those in control group; Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin + Par-4 group were greatly higher than those in cisplatin group and Par-4 group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly significantly lower than those in cisplatin group and Par-4 group. Conclusion: Par-4 gene overexpression can increase the nephroblastoma sensitivity to cisplatin, reduce cell proliferation activity, promote apoptosis and inhibit cell migration and invasion.

  13. Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

    Science.gov (United States)

    Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

    2015-04-20

    During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Economic Management of a Centre for Processing Radioactive Residues; Gestion Economique D'un Centre de Traitement de Residus Radioactifs; Ehkonomicheskij aspekt obrashcheniya s radioaktivnymi otkhodami v obrabatyvayushchem tsentre; Gestion Economica de un Centro de Tratamiento de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Van Lint, J. M. [BELGONUCLEAIRE, Bruxelles (Belgium)

    1966-02-15

    The paper shows the differences between the operations of an industrial undertaking and an installation for residue processing and describes the auditing system of an industry concerned with various phases of processing. It shows that the auditing programme is necessarily and intimately connected with the general organization of the entire undertaking and that it is a useful tool of economic management. In this connection, the paper deals at length with the auditing principles used in arriving at - the overall cost of the final product, - the specific cost of each processing phase,. (author) [French] Apres avoir expose les differences existant entre les operations effectuees par une entreprise industrielle et par une installation de traitement des residus, le memoire decrit la comptabilite d'une industrie comprenant plusieurs phases de traitement. Il montre comment le plan comptable est necessairement et intimement lie a l'organisation generale de l'ensemble de l'entreprise et est un outil utile de gestion economique, A cette fin, le memoire developpe les principes comptables permettant d'etablir: - le prix de revient global du produit final obtenu, - les prix de revient specifiques de chaque phase de traitement partiel. (author) [Spanish] Despues de exponer las diferencias que existen entre las operaciones efectuadas en una empresa industrial y en una instalacion de tratamiento de desechos, el autor analiza la contabilidad de una industria que comprende diversas fases de tratamiento. Muestra como el plan contable esta necesaria e intimamente vinculado a la organizacion general del conjunto de la empresa y es un instrumento util de gestion economica. Con este fin, desarrolla los principios contables que permiten establecer: - el precio de costo global del producto final obtenido, - los precios de costo especificos de cada fase de tratamiento parcial. (author) [Russian] Posle Izlozhenija Razlichij, Sushhestvujushhih Mezhdu Operacijami Na Promyshlennom Predprijatii I

  15. Measurement of the wear rate of cast grinding balls using radioactive tracers; Evaluation de l'usure des boulets pour concasseurs, au moyen des indicateurs radioactifs; Izmerenie skorosti iznosa litykh drobil'nykh sharov pri pomoshchi mechenykh atomov; Medicion de la velocidad de desgaste de bolas trituradoras de acero colado con ayuda de indicadores radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Keys, J D; Eichholz, G G [Department of Mines and Technical Surveys, Ottawa, ON (Canada)

    1962-01-15

    The wear rate of grinding balls used in ball mills is usually hard to determine under operational conditions and little is known-about the factors determining ball life. Radioactive tracers have been used successfully to mark cast steel balls to obtain information on their life under various operating conditions for comparison with balls of different type or composition. A batch of marked steel balls has been followed through a milling operation over several weeks and statistics on wear and loss of weight have been obtained. In the test runs cobalt-60 was added to the molten metal before casting and the balls were then observed in use at an iron mine. The radioactive batch was added to a ball mill with a normal charge of about 75 tons and the mill charge was sampled at weekly intervals to pick out active balls. These balls were inspected and weighed, and the wear rate has been calculated. This procedure has proved to be a practical way of investigating wear properties under plant operating conditions. (author) [French] Il est en general difficile de determiner le taux d'usure des boulets de broyeurs dans des conditions normales d'utilisation et l'on ne sait pas grand-chose des facteurs qui determinent la longevite des boulets. Les auteurs ont employe avec succes des indicateurs radioactifs pour marquer des boulets d'acier moule, en vue d'obtenir des indications sur leur duree dans diverses conditions de. fonctionnement et de faire une comparaison entre des boulets de type different ou de. composition differente. Ils ont suivi un lot de boulets, d'acier ainsi marques pendant une operation de broyage qui a dirre plusieurs semaines, ce qui a permis de recueillir des donnees statistiques sur leur usure et leur perte de poids. Au cours des essais, du cobalt-60 a ete ajoute au metal fondu avant le moulage des boulets. Ceux-ci ont ete ensuite maintenus en observation pendant leur emploi dans une mine de fer et une mine d'or. Le lot radioactif a ete introduit danfe un

  16. Equações de chuvas intensas para o estado do Pará Intense rainfall equations for the state of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo O. R. de M. Souza

    2012-09-01

    Full Text Available As equações de chuvas intensas têm sido usadas como ferramenta importante para o dimensionamento de obras hidráulicas. Devido à grande carência de informações relativas às equações de chuvas intensas, o presente trabalho teve como objetivo a obtenção das relações de intensidade, duração e frequência de precipitação pluvial para o Estado do Pará, utilizando-se a metodologia da desagregação da chuva de 24 h. Foram utilizadas séries históricas de dados pluviométricos de 74 cidades do Estado do Pará, obtidas no Sistema de Informações Hidrológicas da Agência Nacional de Águas-ANA. As equações de intensidade-duração-frequência foram devidamente ajustadas e apresentaram bom ajuste, com coeficientes de determinação acima de 0,99. A maioria das estações (51,4% apresentou intensidade de precipitação entre 90 e 110 mm h-1, para uma duração de chuva de 30 min e um tempo de retorno de 15 anos. Pode-se perceber uma concentração das maiores precipitações na região próxima ao litoral do nordeste paraense e no sudeste da Ilha do Marajó.The intense rainfall equations have been used as an important tool for design of hydraulic structures. Considering the lack of intense rainfall equations, this study aimed to determine the relations of intensity, duration and frequency of intense rainfall in the Pará State (Brazil, using the one-day rain disaggregation method. In this research rainfall data of 74 cities in the State of Pará were used, obtained from the Hydrological Information System of the National Water Agency-ANA. The equations of intensity-duration-frequency were adjusted and presented good adjustment with coefficients of determination above 0.99. Most stations (51.4% showed intensity of precipitation between 90 and 110 mm h-1 for duration of 30 min and rainfall return period of 15 years. The highest rainfall intensities were in the region near the northeast coast of Pará State and southeast of the Marajo

  17. écrivain-e. Par-delà le genre – par-delà le corps ?

    Directory of Open Access Journals (Sweden)

    Cécile Chamayou-Kuhn

    2009-12-01

    Full Text Available Cet article propose d’étudier la relation qu’entretiennent, d’une part, le langage et le corps et, d’autre part, la parole et l’identité sexuelle dans Die Kränkung d’Evelyn Schlag et Der Tod und das Mädchen : III (Rosamunde ; V (Die Wand d’Elfriede Jelinek. Malgré les divergences de ton que présentent ces oeuvres, qui appartiennent à deux genres littéraires différents, il semble permis de centrer l’analyse sur une problématique commune : le personnage de « l’écrivain-e » parvient-il à saisir son propre corps ? Dans cette perspective, nous nous appuyons sur la critique formulée par Judith Butler à l’égard de la psychanalyse lacanienne, tout en considérant sa théorie sur la construction discursive du corps. Trois thématiques peuvent être développées : la dialectique de « l’in-visibilité » féminine, les processus de matérialisation du corps et la pratique subversive de la mascarade en tant qu’elle met en évidence certains mécanismes d’aliénation dans le cadre d’une genèse du corps et de l’écriture. Aussi peut-on affirmer que le drame du corps investi symboliquement sous-tend ces œuvres : l’écrivain-e tente de s’extraire de l’ordre symbolique et de saper les fondements des catégories constitutives de l’identité que sont le désir, le sexe biologique (sex et l’identité sexuelle (gender. Si les processus d’écriture laissent envisager un dépassement de l’offense narcissique et de la maladie dans Die Kränkung, un tel dénouement paraît exclu dans l’univers jelinekien : ses « héroïnes », qui évoluent comme autant de fantômes du signifiant, entament une éternelle danse de mort.Untersucht wird im folgenden Artikel – anhand der Texte Die Kränkung von Evelyn Schlag und Der Tod und das Mädchen III (Rosamunde und V (Die Wand von Elfriede Jelinek – das Verhältnis von Sprache zum Körper sowie die Beziehung zwischen Sprechen und

  18. Detection of radioactive gases in the CO{sub 2} cooling the reactors G 2 - G 3; Detection des gaz radioactifs dans le CO{sub 2} de refroidissement des piles G2 - G3

    Energy Technology Data Exchange (ETDEWEB)

    Pouthier, J; Rossi, J [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1968-07-01

    The carbon dioxide cooling the reactors G2 - G3 contains activation gases and fission gases. It is of interest to know their concentration, for example to be able to deduce rapidly the norms which would have to be applied in the case of an incident in the circuit. Gas-phase chromatography is applied daily for carrying out analyses. The chromatogram has separate peaks due to tritium, argon 41, krypton 85 and the 133 and 135 isotopes of xenon. By integrating each peak it is possible to calculate the specific activity of each product. The construction of an apparatus for carrying out continuous measurements is under consideration. (authors) [French] Le gaz carbonique, refroidissant les reacteurs G2 - G3, contient des gaz d'activation et des gaz de fission. Il est interessant de connaitre leur teneur par exemple pour etre en mesure de deduire rapidement les normes qu'il y aurait lieu d'appliquer en cas d'incidents sur le circuit. La methode de chromatographie en phase gazeuse est employee quotidiennement pour faire des analyses. Le chromatogramme se presente sous forme de pics distincts dus au tritium, a l'argon 41, au krypton 85 et aux isotopes 133 et 135 du xenon. L'integration de chaque pic permet de calculer l'activite specifique de chaque compose. Il est envisage de construire un appareil pour des mesures en continu. (auteurs)

  19. Treatment, as radio-active waste, of large pieces of {proportional_to}-contaminated apparatus (1962); Conditionnement en tant que dechet radioactif de gros materiel contamine en {proportional_to} (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Boutot, P; Capitaine, A; Giachetto, I [Commissariat a l' Energie Atomique, Centre de Production de Plutonium, Marcoule (France). Centre d' Etudes Nucleaires

    1962-07-01

    Two solutions have been adopted: - removal of the material from its original container, treatment in a special container; - treatment of the material directly inside its original protective packing. The treatment of a fluorination oven illustrates the second process. After a thorough cleaning of the enclosure, the oven is fixed in and the contamination held in place by a varnish. The assembly is placed in a special container and covered with shaken-down concrete. The container is shut by means of a welded cover. The operations are carried out under reduced pressure. At the end of this process it is impossible to detect any residual radioactivity. (authors) [French] Deux solutions ont ete adoptees: - extraire le materiel de son enveloppe d'origine et le conditionner dans un container special; - conditionner le materiel directement a l'interieur de la protection d'origine. Le conditionnement d'un four de fluoration illustre le deuxieme procede. Apres un nettoyage complet de l'enceinte, le four en a ete rendu solidaire et la contamination a ete fixee au moyen d'un vernis. L'ensemble a ete place dans un container special et enrobe de beton vibre. Le container a ete ferme par un couvercle soude. L'ensemble des operations a ete realise sous depression. A la suite de ces operations aucune activite residuelle n'a ete decelee. (auteurs)

  20. Urokinase-type plasminogen activator receptor (uPAR), tissue factor (TF) and epidermal growth factor receptor (EGFR)

    DEFF Research Database (Denmark)

    Christensen, Anders; Kiss, Katalin; Lelkaitis, Giedrius

    2017-01-01

    Background: Tumor-specific biomarkers are a prerequisite for the development of targeted imaging and therapy in oral squamous cell carcinoma (OSCC). urokinase-type Plasminogen Activator Receptor (uPAR), Tissue Factor (TF) and Epidermal Growth Factor Receptor (EGFR) are three biomarkers that exhib...... with a reduced survival. uPAR seems to be a prognostic biomarker in oral cancer....

  1. Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review

    NARCIS (Netherlands)

    Backes, Yara; van der Sluijs, Koenraad F.; Mackie, David P.; Tacke, Frank; Koch, Alexander; Tenhunen, Jyrki J.; Schultz, Marcus J.

    2012-01-01

    Systemic levels of soluble urokinase-type plasminogen activator receptor (suPAR) positively correlate with the activation level of the immune system. We reviewed the usefulness of systemic levels of suPAR in the care of critically ill patients with sepsis, SIRS, and bacteremia, focusing on its

  2. Manufactering of par-fried french-fries. Part 3: a blueprint to predict the maximum production yield

    NARCIS (Netherlands)

    Somsen, D.J.; Capelle, A.; Tramper, J.

    2004-01-01

    Very little research on the production yield of par-fried French-fries has been reported in the literature. This paper bridges the knowledge gap and outlines the development of a model to predict the maximum production yield of par-fried French-fries. This yield model can be used to calculate the

  3. L'initiative Agua Limpia para Perú est dirigée par un ancien titulaire ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    9 juil. 2014 ... Au Pérou, de nombreuses sources d'eau sont contaminées par de ... l'accès à une eau propre et la formation sur l'assainissement, les eaux usées et les ... par AguaSAN Perú aux fins du traitement des eaux (en espagnol).

  4. Movement of Radioactive Effluents in Natural Waters at Hanford; Le Mouvement des Effluents Radioactifs dans les Eaux Naturelles a Hanford; 0414 0412 0418 0416 0414 ; Movimiento de los Efluentes Radiactivos en Aguas Naturales en Hanford

    Energy Technology Data Exchange (ETDEWEB)

    Honstead, J. F.; Foster, R. F.; Bierschenk, W. H. [Hanford Laboratories Operation, Hanford Atomic Products Operation, General Electric Company, Richland, WA (United States)

    1960-07-01

    ) [French] L'installation de Hanford se trouve dans une region semi-aride-de sediments non consolides en couche tres epaisse, qui ont ete deposes par les eaux et reposent sur un lit rocheux basaltique. Ces roches forment deux couches geologiques, la couche inferieure etant beaucoup moins permeable que la couche superieure. La Columbia traverse les terrains de l'installation et ce n'est qu'a environ 55 kilometres en aval du dernier reacteur qu'on commence a utiliser les eaux pour la consommation humaine. Les effluents de faible intensite provenant des reacteurs sont evacues dans la Columbia apres un sejour d'une a trqis heuges dans des reservoirs. Dans les effluents, on a pu identifier plus de 60 radioisotopes, qui, pour la plupart, ont y une tres courte periode. On a observe l'appauvrissement de l'eau fluviale en plusieurs radioisotopes par suite de mecanismes autres que la desintegration. Cet appauvrissement atteint 40% en moyenne sur les 55 kilometres qui separent les reacteurs et Pasco; il serait du a des processus d'assimilation biologique et de sedimentation. Les solutions de dechets de faible intensite provenant des usines de traitement chimique sont evacuees dans le sol ou elles filtrent a travers les sediments sur une profondeur de 70 a 120 metres avant d'atteindre la nappe aquifere. Pendant leur passage a travers le sol, la plupart des substances radioactives sont retenues par adsorption ou par d'autres reactions. L'eau et les quelques contaminants qui atteignent le niveau hydrostatique se deplacent avec les eaux souterraines en direction de la Columbia. La vitesse et la direction de ce deplacement sont determines par la forme de la surface piezometrique et les caracteristiques hydrauliques de l'aquifere. La configuration locale de la nappe a ete fortement influencee par l'evacuation de grandes quantites d'eau. Compte tenu du gradient hydraulique et du degre de permeabilite des aquiferes, on estime a 180 annees la duree moyenne du deplacement de J'eau. On reconnait

  5. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-12-30

    A small sample of each of the CALiPER Application Summary Report 20 PAR38 lamp types underwent stress testing that included substantial temperature and humidity changes, electrical variation, and vibration. The results do not directly address expected lifetime, but can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs.

  6. The rate of endophthalmitis after pars plana vitrectomy and its risk factors.

    Science.gov (United States)

    Tabatabaei, Seyed Ali; Soleimani, Mohammad; Vakili, Hadi; Naderan, Morteza; Lashay, Alireza; Faghihi, Houshang; Yaseri, Mehdi

    2018-05-11

    To study the incidence of endophthalmitis after pars plana vitrectomy, its causative organisms, and visual acuity outcomes. In this retrospective, comparative study, the medical records of patients with acute-onset postoperative endophthalmitis after pars plana vitrectomy at Farabi Eye Hospital, Tehran, Iran, during a 12-year period between January 2004 and November 2015 were reviewed. To compare the endophthalmitis patients with other cases who underwent pars plana vitrectomy at the same day and also the same operating room, a control group was developed by gathering the data from surgical records. In the present study, the incidence rate of pos- vitrectomy endophthalmitis was 0.04% (16/39783). The organisms identified in aqueous or vitreous cultures (culture positive 44%) included Streptococcus pneumoniae (two patients, 12.5%), Pseudomonas aeruginosa (two patients, 12.5%), fungi (two patients, 12.5%), and Streptococcus viridans (one patient, 6.25%). Visual acuity after treatment for endophthalmitis ranged from light perception (7 eyes) to hand motion (1 eye), and evisceration was performed in 8 eyes (50%). When comparing the cases (patients developing endophthalmitis) and controls (patients with no complications operated in the same day and place of operation with the case group), only not using tamponade showed a statistically significant relation with the occurrence of endophthalmitis (p = 0.034). Our results indicated low incidence of endophthalmitis after pars plana vitrectomy comparable to previous studies which resulted in poor visual acuity. It seems that not using tamponade might increase the risk of endophthalmitis among these patients.

  7. PAR in Academic and Professional Literature: A comparison of the Recent EU Accession Waves

    NARCIS (Netherlands)

    Junjan, Veronica; Nemec, Juraj

    2016-01-01

    The last twenty years have brought about rather tumultuous changes in terms of the way PAR is being defined, conducted, imitated and, why not, simulated. This paper aims to explore the way scientific literature has addressed the issue of reform in public administration through conducting a

  8. A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization.

    Science.gov (United States)

    Dickinson, Daniel J; Schwager, Francoise; Pintard, Lionel; Gotta, Monica; Goldstein, Bob

    2017-08-21

    Regulated protein-protein interactions are critical for cell signaling, differentiation, and development. For the study of dynamic regulation of protein interactions in vivo, there is a need for techniques that can yield time-resolved information and probe multiple protein binding partners simultaneously, using small amounts of starting material. Here we describe a single-cell protein interaction assay. Single-cell lysates are generated at defined time points and analyzed using single-molecule pull-down, yielding information about dynamic protein complex regulation in vivo. We established the utility of this approach by studying PAR polarity proteins, which mediate polarization of many animal cell types. We uncovered striking regulation of PAR complex composition and stoichiometry during Caenorhabditis elegans zygote polarization, which takes place in less than 20 min. PAR complex dynamics are linked to the cell cycle by Polo-like kinase 1 and govern the movement of PAR proteins to establish polarity. Our results demonstrate an approach to study dynamic biochemical events in vivo. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Par@Graph - a parallel toolbox for the construction and analysis of large complex climate networks

    NARCIS (Netherlands)

    Tantet, A.J.J.

    2015-01-01

    In this paper, we present Par@Graph, a software toolbox to reconstruct and analyze complex climate networks having a large number of nodes (up to at least 106) and edges (up to at least 1012). The key innovation is an efficient set of parallel software tools designed to leverage the inherited hybrid

  10. Identificación de parásitos gastrointestinales en aves silvestres en cautiverio

    OpenAIRE

    García Corredor, Diego José; Sánchez Parada, Oscar Javier; Pulido Medellín, Martin Orlando; Andrade Becerra, Roy José

    2013-01-01

    Este trabajo identifica los parásitos gastrointestinales que presentaron las aves silvestres en cautiverio, en el municipio de Tibasosa (Boyacá, Colombia). Se tomaron 100 muestras de materia fecal de aves silvestres correspondientes a 11 familias (Psittacidae, Ramphastidae, Ophistocomidae, Cracidae, Anatidae, Icteridae, Alaudidae, Burhinidae, Phoenicopteridae, Anhimidae y Rallidae) y 16 especies (Ara ararauna, Ara macao, Amazona spp, Amazona ochrocephala, Ramphastos toco,...

  11. UTILITY OF A WIDE SPECTRUM LIGHT METER AS AN UNDERWATER SENSOR OF PHOTOSYNTHETICALLY ACTIVE RADIATION (PAR)

    Science.gov (United States)

    The strong attenuation of infra red wavelengths (>700 nm) in coastal waters is suggestive that some instruments with broad spectral responses might be useful, inexpensive substitutes for PAR sensors in studies of estuarine plant dynamics. Wide spectrum (350-1100 nm) light intensi...

  12. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    DEFF Research Database (Denmark)

    Bache, Michael; Bosco, Filippo; Brøgger, Anna Line

    2013-01-01

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels...

  13. Jesus en geweld: Markus 12:1-12 (en par) en Thomas 65 | van Eck ...

    African Journals Online (AJOL)

    Jesus and violence: Mark 12:1-12 (and par) and. Thomas 65. As an advanced agrarian (aristocratic) society, first-century Palestine's social fabric was built on systemic tensions and conflicts between the elite (rulers) and the peasantry (the ruled). At the root of these conflicts were incompatible values (ideologies) and

  14. Les politiques de développement élaborées par la Banque ...

    African Journals Online (AJOL)

    constamment de stratégies et de politiques de développement. De théorie en ..... supérieurs, un laxisme dans les règles de recrutement et une insuffisance de ... Par ailleurs, souligne la Banque mondiale (1980), la plupart des entreprises.

  15. uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS

    Directory of Open Access Journals (Sweden)

    Mariana Rodrigues Faleiro

    2013-06-01

    Full Text Available Prostatic lesions such as prostatic intraepithelial neoplasia (PIN and proliferative inflammatory atrophy (PIA are studied in human and canine species due to their malignance potential. The plasminogen activator (PA system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC was evaluated by immunohistochemistry in a tissue microarray (TMA slide to establish the role of this enzyme in extracellular matrix (ECM remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1% normal prostates, 46 (13.0% with BPH, 128 (36.1% with PIA, 74 (20.8% with PIN and 71 (20.0% with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.

  16. 27 Segmentation par logique floue pour l'estimation du nombre de ...

    African Journals Online (AJOL)

    bagui kossan olivier

    Le diagnostic rapide est par conséquent, une urgence médicale car, le ... Vision Allied Technology, avec un capteur de MT9P031 de Micron / Aptina), avec ..... [4] - O. K. BAGUI, J. T. ZOUEU, C. WÄHLBY, Automatic malaria diagnosis by the ...

  17. La bio-indication de la pollution aquatique par les microalgues (Cas ...

    African Journals Online (AJOL)

    ecosystCmes et introduisent des micro- organismes pathogmes qui ... organismes vivants dont on connait la sensibilite et les exigences ..... En effet, certains genres proliferent dans des milieux acides, alors que d'autres preferent des milieux alcalins. Par ailleurs, dans les milieux a fortes teneurs en elements acides tel que ...

  18. Rupture Uterine Par Accident De La Voie Publique: A propos d'un cas.

    African Journals Online (AJOL)

    Abstract. Un cas de rupture utérine par accident de la voie publique associée à une fracture de l'humérus droit et du bassin est décrit. Les pronostics maternels et foetal sont discutés à la lumière de la revue de la littérature.

  19. Evaluation de la Qualité de surface par la Dimension Fractale et les ...

    African Journals Online (AJOL)

    Evaluation of surface quality by Fractal Dimension and Volume. Parameters .... du microscope électronique à balayage la. FEG.SUPRA 40. ... telle configuration le rapport (L/Dp), est tel que : L0 ,75 ..... du contrôle par la dimension fractale ;.

  20. Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

    Czech Academy of Sciences Publication Activity Database

    Olejár, Tomáš; Větvička, D.; Zadinová, M.; Poučková, P.; Kukal, J.; Ježek, Petr; Matěj, R.

    2014-01-01

    Roč. 34, č. 7 (2014), s. 3511-3515 ISSN 0250-7005 R&D Projects: GA ČR(CZ) GAP302/10/0346 Institutional support: RVO:67985823 Keywords : PAR2 * melanoma * metastasis * murine model Subject RIV: EA - Cell Biology Impact factor: 1.826, year: 2014

  1. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration.

    Science.gov (United States)

    Pichaud, Franck

    2018-01-01

    The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb) are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM) and zonula adherens (ZA) , thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1) gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  2. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration

    Directory of Open Access Journals (Sweden)

    Franck Pichaud

    2018-03-01

    Full Text Available The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM and zonula adherens (ZA, thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1 gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  3. 102 La décoloration des rejets liquides de textile (noir de soufre) par ...

    African Journals Online (AJOL)

    pc

    Résumé. Dans cette étude, nous nous intéressons au traitement d'un rejet de coloration de textile par voie ... L'industrie textile utilise environs 10 000 types de colorants, la ..... Electrochemical coagulation for textile effluent decolorization.

  4. L'obtention du crédit bancaire par les PME au Cameroun

    African Journals Online (AJOL)

    Doctorante en sciences de gestion Université de Ngaoundéré, Cameroun. .... vient à point nommé dans son contexte et dans son domaine dans la mesure ... confrontant la performance des entreprises à leur structure financière, Wanda ..... est le plus souvent la perte du contrôle de l'entreprise par les actionnaires.

  5. Two-year survival of glass ionomer sealanTs placed as parT of ...

    African Journals Online (AJOL)

    2010-09-09

    Sep 9, 2010 ... Two-year survival of glass ionomer sealanTs placed as parT of proximal aTraumaTic. resToraTive ... absTracT. Objective: To evaluate after two years, the survival rate of glass ionomer cement (gic) ... or symptoms of periodontal disease, and clinically the ..... saliva contamination on the bond of dentine resin-.

  6. PAR as a way of organising a social workers labour union in Greenland

    DEFF Research Database (Denmark)

    Andersen, John; Arnfjord, Steven

    Abstract, ALARA2015012:PAR as a way of organising a social workers labour union in Greenland for consideration and inclusion in the programme for the ALARA 9th Action Learning Action Research and 13th Participatory Action Research World Congress to be held at St. George Hotel and Conference Centre...

  7. Determining fPAR and leaf area index of several land cover classes ...

    African Journals Online (AJOL)

    ... fraction of photosynthetically active radiation (fPAR), are three fundamental biophysical characteristics of the plant canopy that should parameterise ecophysiological models of water use (evapotranspiration) and carbon sequestration. Although Earth observation provides values and time series for both these parameters, ...

  8. Funding Research Through the Online Partnership to Accelerate Research (OnPAR

    Directory of Open Access Journals (Sweden)

    Martin A. Dueñas, MPA

    2016-10-01

    Full Text Available OnPAR—the Online Partnership to Accelerate Research—seeks to provide a second opportunity for funding of high-quality, unfunded applications originally submitted to the National Institutes of Health and other national and international funding agencies. OnPAR will match applicable, unfunded applications with the research priorities of nongovernment organizations such as private biomedical foundations, pharmaceutical companies, venture capital funds, and other private funds. Funding organization members will review and make final funding decisions through a simple, 2-step process whereby applicants can submit public abstracts directly to OnPAR. If a member requests additional information, then, by invitation only, an applicant can submit their original unfunded application and their peer review summary statement. Advancing research discovery and drug development to improve clinical outcomes for patients afflicted with or at risk for disease is the primary goal of OnPAR. OnPAR invites the scientific community to fully participate in this new funding paradigm by submitting their National Institutes of Health public abstracts so that funding members can review and potentially support these high-quality, unfunded applications.

  9. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4 exhibits growth inhibitory effects in prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Shayan eSarkar

    2015-10-01

    Full Text Available The gene Par-4 (Prostate Apoptosis Response 4 was originally identified in prostate cancer cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic activity. Particularly, the SAC domain of Par-4 (SAC-Par-4 selectively kills cancer cells leaving normal cells unaffected. The therapeutic significance of bioactive SAC-Par-4 is enormous in cancer biology; however, its large scale production is still a matter of concern. Here we report the production of SAC-Par-4-GFP fusion protein coupled to translational enhancer sequence (5′ AMV and apoplast signal peptide (aTP in transgenic Nicotiana tabacum cv. Samsun NN plants under the control of a unique recombinant promoter M24. Transgene integration was confirmed by genomic DNA PCR, Southern and Northern blotting, Real-time PCR and Nuclear run-on assays. Results of Western blot analysis and ELISA confirmed expression of recombinant SAC-Par-4-GFP protein and it was as high as 0.15% of total soluble protein. In addition, we found that targeting of plant recombinant SAC-Par-4-GFP to the apoplast and endoplasmic reticulum (ER was essential for the stability of plant recombinant protein in comparison to the bacterial derived SAC-Par-4. Deglycosylation analysis demonstrated that ER-targeted SAC-Par-4-GFP-SEKDEL undergoes O-linked glycosylation unlike apoplast-targeted SAC-Par-4-GFP. Furthermore, various in vitro studies like mammalian cells proliferation assay (MTT, apoptosis induction assays, and NF-κB suppression suggested the cytotoxic and apoptotic properties of plant-derived SAC-Par-4-GFP against multiple prostate cancer cell lines. Additionally, pre-treatment of MAT-LyLu prostate cancer cells with purified SAC-Par-4-GFP significantly delayed the onset of tumor in a syngeneic rat prostate cancer model. Taken altogether, we proclaim that plant made SAC-Par-4 may become a useful alternate therapy for effectively alleviating cancer in the new era.

  10. Heat transfer in smooth tubes, between parallel plates, along a semi-infinite plate, in annular spaces and along tube bundles for exponential distribution of the heat flux in forced, laminar or turbulent flow; Transfert de chaleur dans des tubes lisses, entre des plaques planes paralleles, le long d'une plaque plane, dans des espaces annulaires et le long de faisceaux tubulaires pour une repartition exponentielle du flux de chaleur en ecoulement force, laminaire ou turbulent

    Energy Technology Data Exchange (ETDEWEB)

    Graber, H [Commissariat a l' Energie Atomique, 91 - Saclay (France). Centre d' Etudes Nucleaires

    1969-04-01

    By introducing an additional parameter F{sub 0}, the processes known hitherto for calculating heat transfer are extended to the heat flux distributions following an exponential law q{sub w} = exp(mx) which give a heat transfer coefficient, independent of position for laminar and turbulent flow with a linear pressure drop. For laminar flow along a semi-infinite plate, the heat flux distribution in accordance with the law qw = x{sup m} leads to the Nusselt number, regardless of the position. Nu is then determined by the thickness of the thermal boundary layer. For the annular space, the equations for explicit calculation of the temperature field will be given, as well as the Nusselt number in laminar flow and constant heat flux. In turbulent flow, the laws of distribution of eddy diffusivity for momentum in a tube, established by H. Reichardt, adapted for the annular space and the tube bundle, give the velocity field and the coefficient of friction and thus permit solution of the heat transfer equations. The results of the numerical calculation are given in the tables and diagrams for an extended range of the various parameters and compared with the experimental results. A simple process to determine the lower limit of the thermal entry length will be described. (author) [French] Par l'introduction d'un parametre supplementaire F{sub 0}, les procedes connus jusqu'a present pour le calcul du transfert de chaleur sont etendus aux repartitions exponentielles q{sub w} = exp(mx) du flux de chaleur qui indiquent un coefficient de transfert de chaleur independant de l'endroit pour l'ecoulement laminaire ou turbulent avec chute de pression lineaire. Pour l'ecoulement laminaire le long d'une plaque plane, la repartition du flux de chaleur selon la loi q{sub w} = x{sup m} conduit au nombre de Nusselt independant de l'endroit. Nu est alors determine par l'epaisseur de la couche limite thermique. Pour l'espace annulaire, seront indiquees les equations pour le calcul explicite du

  11. Heat transfer in smooth tubes, between parallel plates, along a semi-infinite plate, in annular spaces and along tube bundles for exponential distribution of the heat flux in forced, laminar or turbulent flow; Transfert de chaleur dans des tubes lisses, entre des plaques planes paralleles, le long d'une plaque plane, dans des espaces annulaires et le long de faisceaux tubulaires pour une repartition exponentielle du flux de chaleur en ecoulement force, laminaire ou turbulent

    Energy Technology Data Exchange (ETDEWEB)

    Graber, H. [Commissariat a l' Energie Atomique, 91 - Saclay (France). Centre d' Etudes Nucleaires

    1969-04-01

    By introducing an additional parameter F{sub 0}, the processes known hitherto for calculating heat transfer are extended to the heat flux distributions following an exponential law q{sub w} = exp(mx) which give a heat transfer coefficient, independent of position for laminar and turbulent flow with a linear pressure drop. For laminar flow along a semi-infinite plate, the heat flux distribution in accordance with the law qw = x{sup m} leads to the Nusselt number, regardless of the position. Nu is then determined by the thickness of the thermal boundary layer. For the annular space, the equations for explicit calculation of the temperature field will be given, as well as the Nusselt number in laminar flow and constant heat flux. In turbulent flow, the laws of distribution of eddy diffusivity for momentum in a tube, established by H. Reichardt, adapted for the annular space and the tube bundle, give the velocity field and the coefficient of friction and thus permit solution of the heat transfer equations. The results of the numerical calculation are given in the tables and diagrams for an extended range of the various parameters and compared with the experimental results. A simple process to determine the lower limit of the thermal entry length will be described. (author) [French] Par l'introduction d'un parametre supplementaire F{sub 0}, les procedes connus jusqu'a present pour le calcul du transfert de chaleur sont etendus aux repartitions exponentielles q{sub w} = exp(mx) du flux de chaleur qui indiquent un coefficient de transfert de chaleur independant de l'endroit pour l'ecoulement laminaire ou turbulent avec chute de pression lineaire. Pour l'ecoulement laminaire le long d'une plaque plane, la repartition du flux de chaleur selon la loi q{sub w} = x{sup m} conduit au nombre de Nusselt independant de l'endroit. Nu est alors determine par l'epaisseur de la couche limite thermique. Pour l'espace annulaire, seront

  12. Project Plan 7930 Cell G PaR Remote Handling System Replacement

    International Nuclear Information System (INIS)

    Kinney, Kathryn A.

    2009-01-01

    For over 40 years the US Department of Energy (DOE) and its predecessors have made Californium-252 ( 252 Cf) available for a wide range of industries including medical, nuclear fuels, mining, military and national security. The Radiochemical Engineering Development Center (REDC) located within the Oak Ridge National Laboratory (ORNL) processes irradiated production targets from the High Flux Isotope Reactor (HFIR). Operations in Building 7930, Cell G provide over 70% of the world's demand for 252 Cf. Building 7930 was constructed and equipped in the mid-1960s. Current operations for 252 Cf processing in Building 7930, Cell G require use of through-the-wall manipulators and the PaR Remote Handling System. Maintenance and repairs for the manipulators is readily accomplished by removal of the manipulator and relocation to a repair shop where hands-on work can be performed in glove boxes. Contamination inside cell G does not currently allow manned entry and no provisions were created for a maintenance area inside the cell. There has been no maintenance of the PaR system or upgrades, leaving operations vulnerable should the system have a catastrophic failure. The Cell G PaR system is currently being operated in a run to failure mode. As the manipulator is now 40+ years old there is significant risk in this method of operation. In 2006 an assessment was completed that resulted in recommendations for replacing the manipulator operator control and power centers which are used to control and power the PaR manipulator in Cell G. In mid-2008 the chain for the bridge drive failed and subsequent examinations indicated several damaged links (see Figure 1). To continue operations the PaR manipulator arm is being used to push and pull the bridge as a workaround. A retrieval tool was fabricated, tested and staged inside Cell G that will allow positioning of the bridge and manipulator arm for removal from the cell should the PaR system completely fail. A fully functioning and

  13. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    International Nuclear Information System (INIS)

    Dunn, Andrew J.; Campbell, Robert S.D.; Mayor, Peter E.; Rees, Dai

    2008-01-01

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  14. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, Andrew J.; Campbell, Robert S.D. [Royal Liverpool and Broadgreen University Teaching Hospitals, Department of Medical Imaging, Liverpool (United Kingdom); Mayor, Peter E. [Leighton Hospital, Department of Medical Imaging, Crewe, Cheshire (United Kingdom); Rees, Dai [Robert Jones and Agnes-Hunt Orthopaedic Hospital, Department of Orthopaedic Surgery, Oswestry, Shropshire (United Kingdom)

    2008-05-15

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of

  15. Spondylolysis outcomes in adolescents after direct screw repair of the pars interarticularis.

    Science.gov (United States)

    Snyder, Laura A; Shufflebarger, Harry; O'Brien, Michael F; Thind, Harjot; Theodore, Nicholas; Kakarla, Udaya K

    2014-09-01

    Isthmic spondylolysis can significantly decrease functional abilities, especially in adolescent athletes. Although treatment can range from observation to surgery, direct screw placement through the fractured pars, or Buck's procedure, may be a more minimally invasive procedure than the more common pedicle screw-hook construct. Review of surgical databases identified 16 consecutive patients treated with Buck's procedure from 2004 to 2010. Twelve patients were treated at Miami Children's Hospital and 4 at Barrow Neurological Institute. Demographics and clinical and radiographic outcomes were recorded and analyzed retrospectively. The 16 patients had a median age of 16 years, and 14 were 20 years or younger at the time of treatment. Symptoms included axial back pain in 100% of patients with concomitant radiculopathy in 38%. Pars defects were bilateral in 81% and unilateral in 19% for a total of 29 pars defects treated using Buck's procedure. Autograft or allograft augmented with recombinant human bone morphogenetic protein as well as postoperative bracing was used in all cases. Postoperatively, symptoms resolved completely or partially in 15 patients (94%). Of 29 pars defects, healing was observed in 26 (89.6%) prior to 1 revision surgery, and an overall fusion rate of 97% was observed at last radiological follow-up. There were no implant failures. All 8 athletes in this group had returned to play at last follow-up. Direct screw repair of the pars interarticularis defect as described in this series may provide a more minimally invasive treatment of adolescent patients with satisfactory clinical and radiological outcomes, including return to play of adolescent athletes.

  16. Incorporating GOES Satellite Photosynthetically Active Radiation (PAR) Retrievals to Improve Biogenic Emission Estimates in Texas

    Science.gov (United States)

    Zhang, Rui; White, Andrew T.; Pour Biazar, Arastoo; McNider, Richard T.; Cohan, Daniel S.

    2018-01-01

    This study examines the influence of insolation and cloud retrieval products from the Geostationary Operational Environmental Satellite (GOES) system on biogenic emission estimates and ozone simulations in Texas. Compared to surface pyranometer observations, satellite-retrieved insolation and photosynthetically active radiation (PAR) values tend to systematically correct the overestimation of downwelling shortwave radiation in the Weather Research and Forecasting (WRF) model. The correlation coefficient increases from 0.93 to 0.97, and the normalized mean error decreases from 36% to 21%. The isoprene and monoterpene emissions estimated by the Model of Emissions of Gases and Aerosols from Nature are on average 20% and 5% less, respectively, when PAR from the direct satellite retrieval is used rather than the control WRF run. The reduction in biogenic emission rates using satellite PAR reduced the predicted maximum daily 8 h ozone concentration by up to 5.3 ppbV over the Dallas-Fort Worth (DFW) region on some days. However, episode average ozone response is less sensitive, with a 0.6 ppbV decrease near DFW and 0.3 ppbV increase over East Texas. The systematic overestimation of isoprene concentrations in a WRF control case is partially corrected by using satellite PAR, which observes more clouds than are simulated by WRF. Further, assimilation of GOES-derived cloud fields in WRF improved CAMx model performance for ground-level ozone over Texas. Additionally, it was found that using satellite PAR improved the model's ability to replicate the spatial pattern of satellite-derived formaldehyde columns and aircraft-observed vertical profiles of isoprene.

  17. Disposal of Low-Activity Waste and Accumulation in Cultivated Soils; Rejets d'Effluents Faiblement Radioactifs et Accumulation dans les Sols Cultives; 0416 0418 0414 ; Desechos y Efluentes de Baja Actividad: Su Acumulacion en los Terrenos Cultivados

    Energy Technology Data Exchange (ETDEWEB)

    Barbier, G. [Station Centrale d' Agronomie, Versailles (France); Michon, G. [Service d' Hygiene Atomique et de Radiopathologie, Centre d' Etudes Nucleaires, Saclay (France)

    1960-07-01

    The paper describes a method of accumulating long-lived radioisotopes in soils and calculating the maximum contamination they would cause in vegetables grown on these soils. The authors suggest a way of expressing this contamination and a formula by which the maximum contamination of one kilogramme of the harvested produce in relation to the tolerated contamination per litre of irrigation water could be calculated. (author) [French] L'article decrit une methode destinee a prevoir l'accumulation des radioelements de longue periode dans les sols et a chiffrer la contamination limite qui en resultera pour des legumes cultives sur ces sols. Les auteurs proposent un mode d'expression de cette contamination et une formule qui permettrait de calculer la contamination limite d'un kg de produit recolte par rapport a la contamination toleree d'un litre d'eau d'irrigation. (author) [Spanish] En la memoria se describe un metodo para evaluar la acumulacion de los radioelementos de periodo largo en los terrenos y para calcular la contaminacion limite resultante para las hortalizas cultivadas en dichos terrenos. Los autores proponen un metodo para expresar dicha contaminacion y una formula que permita determinar la contaminacion limite de un kilogramo de producto cosechado en funcion de la contaminacion admisible por litre de agua de riego. (author) [Russian] V stat'e opisyvaetsja metod, pozvoljajushhij predvidet' nakoplenie dolgozhivushhih radioaktivnyh izotopov v pochve i opredeljat' predel'nyj uroven' vytekajushhego iz jetogo zarazhenija dlja ovoshhej, vyrashhivaemyh na jetih zemljah. Avtory stat'i predlagajut metod vyrazhenija jetogo zarazhenija i formulu, pozvoljajushhuju vychislit' predel'nyj uroven' zarazhenija odnogo kilogramma ovoshhej po otnosheniju k dopustimomu urovnju zarazhenija odnogo litra oroshajushhej vody. (author)

  18. Monitoring of Fresh Waters Used for Dispersal of Radioactive Wastes; Controle des Eaux Fluviales Utilisees pour la Dispersion des Dechets Radioactifs; 0418 0417 041c 0414 ; Monitoraje de las Aguas Dulces Utilizadas para la Dispersion de Desechos Radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Ophel, I. L. [Environmental Research and Radiation Dosimetry Branch, Division of Biology and Health Physics, Atomic Energy of Canada Limited, Chalk River, ON (Canada)

    1960-07-01

    The Ottawa River is a very large river. The water has a low solids content with little plankton. In many ways the river resembles a lake. Effluent is diluted, into a great volume of low-activity cooling water and enters the river at a concentration of radionuclides less than the MPCW for occupational workers. The concentration of total B {gamma} radionuclides above the plant is 2 x 10{sup -8} {mu}c/ml, and 1.6 km below the plant it is 3 x 10{sup -8} {mu}c/ml. Sampling of the river bottom shows that its radioactivity has been decreasing for several years in spite of continuous addition of activity adsorbed on colloidal silica deposited from the water. Large fish are the only river organisms used by man. Traces of Sr{sup 90} have occasionally been found in the bones, but none in the flesh. Although P{sup 32} forms only 0.04% of the total radioactivity found in the effluent, it makes up 75-95% of the total radionuclides found in most samples. A maximum concentration of 10{sup -3} {mu}c/g wet weight has been found in the whole bodies of small perch. (author) [French] Ottawa est un tres grand fleuve. Ses eaux ne contiennent que peu' de substances solides, notamment peu de plancton. A bien des egards, ce fleuve ressemble a un lac. Les effluents sont dilues dans. une grande quantite d'eau de refroidissement, de faible activite; lorsqu'ils penetrent dans le fleuve, leur concentration en radionuclides est inferieure a la concentration maximum admissible dans l'eau pour les travailleurs exposes professionnellement. La concentration totale en emetteurs beta et gamma est 2 x 10{sup -8} {mu}c/ml en amont de l'usine et 3 x 10{sup -8} {mu}c/ml a 1,6 km en aval. Les echantillons preleves au fond du fleuve montrent que sa radioactivite diminue depuis plusieurs annees, en depit des apports continuels de l'activite adsorbee par les silices colloiedaux en suspension qui se deposent. Les seuls organismes presents dans le fleuve et utilises par l'homme sont les gros poissons. On a

  19. Screening of phytochemicals against protease activated receptor 1 (PAR1), a promising target for cancer.

    Science.gov (United States)

    Kakarala, Kavita Kumari; Jamil, Kaiser

    2015-02-01

    Drug resistance and drug-associated toxicity are the primary causes for withdrawal of many drugs, although patient recovery is satisfactory in many instances. Interestingly, the use of phytochemicals in the treatment of cancer as an alternative to synthetic drugs comes with a host of advantages; minimum side effects, good human absorption and low toxicity to normal cells. Protease activated receptor 1 (PAR1) has been established as a promising target in many diseases including various cancers. Strong evidences suggest its role in metastasis also. There are no natural compounds known to inhibit its activity, so we aimed to identify phytochemicals with antagonist activity against PAR1. We screened phytochemicals from Naturally Occurring Plant-based Anticancer Compound-Activity-Target database (NPACT, http://crdd.osdd.net/raghava/npact/ ) against PAR1 using virtual screening workflow of Schrödinger software. It analyzes pharmaceutically relevant properties using Qikprop and calculates binding energy using Glide at three accuracy levels (high-throughput virtual screening, standard precision and extra precision). Our study led to the identification of phytochemicals, which showed interaction with at least one experimentally determined active site residue of PAR1, showed no violations to Lipinski's rule of five along with predicted high human absorption. Furthermore, structural interaction fingerprint analysis indicated that the residues H255, D256, E260, S344, V257, L258, L262, Y337 and S344 may play an important role in the hydrogen bond interactions of the phytochemicals screened. Of these residues, H255 and L258 residues were experimentally proved to be important for antagonist binding. The residues Y183, L237, L258, L262, F271, L332, L333, Y337, L340, A349, Y350, A352, and Y353 showed maximum hydrophobic interactions with the phytochemicals screened. The results of this work suggest that phytochemicals Reissantins D, 24,25-dihydro-27-desoxywithaferin A, Isoguaiacin

  20. [Roles of protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, in modulation of exocrine gland functions].

    Science.gov (United States)

    Nishikawa, Hiroyuki

    2006-07-01

    Protease-activated receptor-2 (PAR-2), a G protein-coupled receptor, is activated by proteolytic unmasking of the N-terminal extracellular tethered ligand that presumably binds to the extracellular loop 2 of the receptor itself. PAR-2 is widely distributed in the mammalian body and plays various roles in biological events in the cardiovascular, respiratory, alimentary, and central neurons systems. PAR-2-activating peptides administered systemically to mice and rats trigger prompt salivation in vivo. In an in vitro study, PAR-2 agonists including the endogenous PAR-2 activator trypsin induce secretion of amylase and mucin from isolated rat parotid glands and sublingual glands, respectively. PAR-2-activating peptides administered systemically also modulate pancreatic exocrine secretion in vivo as well as in vitro. In the gastric mucosa, PAR-2 stimulation enhances secretion of mucus and pepsinogen and suppresses acid secretion. Tear secretion can also be caused by PAR-2-related peptides in PAR-2-dependent and -independent manners. PAR-2 thus plays a general or key role in the regulation of exocrine secretion. This review focuses on the physiologic and/or pathophysiologic roles of PAR-2 in glandular exocrine secretion. The possibility of PAR-2 as a target for drug development is also discussed.

  1. The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran

    Directory of Open Access Journals (Sweden)

    Roghayeh Nouri

    Full Text Available Abstract The aim of this study was to examine mutations in the quinolone-resistance-determining region (QRDR of gyrA and parC genes in Pseudomonas aeruginosa isolates. A total of 100 clinical P. aeruginosa isolates were collected from different university-affiliated hospitals in Tabriz, Iran. Minimum inhibitory concentrations (MICs of ciprofloxacin and levofloxacin were evaluated by agar dilution assay. DNA sequences of the QRDR of gyrA and parC were determined by the dideoxy chain termination method. Of the total 100 isolates, 64 were resistant to ciprofloxacin. No amino acid alterations were detected in gyrA or parC genes of the ciprofloxacin susceptible or ciprofloxacin intermediate isolates. Thr-83 → Ile substitution in gyrA was found in all 64 ciprofloxacin resistant isolates. Forty-four (68.75% of them had additional substitution in parC. A correlation was found between the number of the amino acid alterations in the QRDR of gyrA and parC and the level of ciprofloxacin and levofloxacin resistance of the P. aeruginosa isolates. Ala-88 → Pro alteration in parC was generally found in high level ciprofloxacin resistant isolates, which were suggested to be responsible for fluoroquinolone resistance. These findings showed that in P. aeruginosa, gyrA was the primary target for fluoroquinolone and additional mutation in parC led to highly resistant isolates.

  2. uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder--Possible Clinical Implications.

    Directory of Open Access Journals (Sweden)

    Line Hammer Dohn

    Full Text Available The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative or positive as well as by the actual score. Separate scores were obtained for cancer cells, macrophages and myofibroblasts at the invasive front and in tumour core. We were able to confirm, in an independent patient cohort, the tissue expression and localisation pattern of uPAR as investigated by Immunohistochemistry as well as a significant association between uPAR positivity and increasing tumour stage and tumour grade. This demonstrates the robustness of our previous and current findings. In addition the association between uPAR positive myofibroblasts and poor survival was reproduced. The highest hazard ratios for survival were seen for uPAR positive myofibroblasts both at the invasive front and in tumour core. Evaluating uPAR expression by the actual score showed a significant association between uPAR positive myofibroblasts in tumour core and an increased risk of cancer specific mortality. Our investigations have generated new and valuable biological information about the cell types being involved in tumour invasion and progression through the plasminogen activation system.

  3. Analysis of gyrA and parC mutations in enterococci from environmental samples with reduced susceptibility to ciprofloxacin

    DEFF Research Database (Denmark)

    Petersen, A.; Jensen, Lars Bogø

    2004-01-01

    The quinolone resistance determining regions of gyrA and parC in four species of enterococci from environmental samples with reduced susceptibility to ciprofloxacin were sequenced. The nucleotide sequence variations of parC could be related to the different enterococcal species. Mutations...... in Enterococcus faecalis and Enterococcus faecium related to reduced susceptibility were identical to mutations detected in E jaecalis and E. faecium of clinical origin. A minimal inhibitory concentration of 8 mug ml(-1) to ciprofloxacin was not associated with any mutations in the gyrA and parC gene...... of Enterococcus casseliflavus and Enterococcus gallinarum. These two species may be intrinsically less susceptible to ciprofloxacin....

  4. Metastatic breast cancer to the liver with hepatoid features and Hep Par 1 antibody positive mimicking hepatocellular carcinoma.

    Science.gov (United States)

    Affleck, Authur; Lyman, William B; Jacobs, W Carl; Livasy, Chad A; Martinie, John B; Iannitti, David A; Vrochides, Dionisios

    2018-05-09

    The hepatocyte paraffin 1 antibody (Hep Par 1) has a high positive predictive value for differentiating hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinoma. 1 We report a case of metastatic breast cancer to the liver with hepatoid histology and strong positive staining for Hep Par 1 mimicking hepatocellular carcinoma. To our knowledge, primary breast carcinoma staining Hep Par 1 positive has not been reported in the setting of hepatic metastasis. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  5. Study of the critical scattering of neutrons by iron; Etude de la diffusion critique des neutrons par le fer

    Energy Technology Data Exchange (ETDEWEB)

    Galula, M; Jacrot, B; Mangin, J P [Commissariat a l' Energie Atomique, Saclay (France)

    1959-07-01

    The critical scattering of very slow neutrons by iron near critical point is measured by time of flight techniques. The VAN HOVE formula is verified and the geometrical parameters K{sub 1} et r{sub 1} introduced in this theory are determined. (author) [French] On etudie la diffusion critique des neutrons tres lents par le fer dans la region du point de Curie par une methode de temps de vol. On verifie la formule de VAN HOVE et on determine les parametres geometriques K{sub 1} et r{sub 1} introduit par ce dernier. (auteur)

  6. Algoritmo PSO para identificación de parámetros en un motor DC

    Directory of Open Access Journals (Sweden)

    César Duarte

    2010-01-01

    Full Text Available En este artículo se presenta la aplicación del algoritmo Particle Swarm Optimization (PSO como estrategia de búsqueda para determinar los parámetros de un sistema tipo caja gris. Este proceso de identificación se ilustra utilizando la respuesta a un escalón de un motor DC en lazo abierto. Para agilizar la identificación del sistema a través del uso de PSO, se limita el espacio de búsqueda usando la información que puede extraerse de la respuesta en el dominio del tiempo del sistema a identificar. Los resultados del proceso de identificación de los parámetros del motor se obtienen utilizando la herramienta PSOt disponible para entorno Matlab® desarrollada por Brian Birge.

  7. Estuarine morphometry governs optically active substances, Kd(PAR) and beam attenuation

    DEFF Research Database (Denmark)

    Lund-Hansen, L. C.; Nielsen, J. M.; Blüthgen, J.

    2013-01-01

    estuaries using OACs as input parameters. It is concluded that there are no large differences in OAC concentrations between the two estuaries. The spatial distributions of OACs and optical properties were significantly different and governed by the estuary morphometry, i.e. a power distribution......°N) at high discharges. The major difference was the spatial distribution of the optical properties against distance, best described by significant power functions in the ria, compared to significant linear functions in the coastal plain. It was hypothesized that estuarine morphometry could explain...... this spatial distribution. Partition and multiple regression analyses showed that Chl-a governed Kd(PAR) and beam attenuation coefficient in both estuaries. Significant, high correlations were obtained by multiple regression analyses in the estimation of Kd(PAR) and beam attenuation coefficients in the two...

  8. Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging

    DEFF Research Database (Denmark)

    Persson, Morten; El Ali, Henrik H.; Binderup, Tina

    2014-01-01

    64Cu-DOTA-AE105 is a novel positron emission tomography (PET) tracer specific to the human urokinase-type plasminogen activator receptor (uPAR). In preparation of using this tracer in humans, as a new promising method to distinguish between indolent and aggressive cancers, we have performed PET...... studies in mice to evaluate the in vivo biodistribution and estimate human dosimetry of 64Cu-DOTA-AE105. MethodsFive mice received iv tail injection of 64Cu-DOTA-AE105 and were PET/CT scanned 1, 4.5 and 22h post injection. Volume-of-interest (VOI) were manually drawn on the following organs: heart, lung......Favorable dosimetry estimates together with previously reported uPAR PET data fully support human testing of 64Cu-DOTA-AE105....

  9. Comprendre la ville par la chrono-chorématique: un essai prometteur

    Directory of Open Access Journals (Sweden)

    Roger Brunet

    2010-12-01

    Full Text Available Cet ensemble de chrono-chorématique urbaine est exemplaire par ses méthodes et par ses résultats. Travail pluridisciplinaire de recherche de grande qualité éthique et esthétique, il livre une approche efficace à la compréhension du développement et des structures urbaines. Il ouvre de larges perspectives comparatives et des voies d’amélioration des modèles généraux de l’élaboration et des transformations des espaces urbains, en relation avec les modèles généraux de la production de l’espace géographique. On souhaite que se multiplient les études de cas, et qu’elles s’étendent à d’autres milieux urbains, à d’autres cultures.

  10. Youth empowerment in context: exploring tensions in school-based yPAR.

    Science.gov (United States)

    Kohfeldt, Danielle; Chhun, Lina; Grace, Sarah; Langhout, Regina Day

    2011-03-01

    In much of the youth empowerment literature, researchers focus on the relationship between youth and adults involved in empowerment programs while neglecting the broader social framework in which these relationships and the program itself functions. Utilizing an ecological model, the current research examines the tensions that surfaced in attempts to create an empowering setting in an after-school PAR program with fifth-graders. Challenging assumptions about youth, structural challenges, and conflicting theories of change are highlighted. Results examine the role of sociocultural context as PAR researchers attempt to create a setting in which students gain skills to become change agents within their school. The study suggests that youth empowerment is a context dependent process that requires attention to a multiplicity of factors that influence possibilities for empowerment via second order change.

  11. Repérer des sites similaires à une recherche par Google

    OpenAIRE

    Ginouvès, Véronique

    2006-01-01

    Repérer des sites similaires à une recherche par Google Afficher graphiquement les liens d’un site avec d’autres sites similaires TouchGraph GoogleBrowser crée des agrégations de sites à partir de l’interrogation de Google. Vous visualisez ainsi des nébuleuses de sites à l’intérieur desquelles vous pouvez naviguer facilement, en sautant d'un groupe à l'autre afin de voir les nuages autour de sujets ou de communautés de sujets. Cet outil a été développé par Alex Shapiro, à partir de la version...

  12. Minimally Invasive Direct Repair of Bilateral Lumbar Spine Pars Defects in Athletes

    Directory of Open Access Journals (Sweden)

    Gabriel A. Widi

    2013-01-01

    Full Text Available Spondylolysis of the lumbar spine has traditionally been treated using a variety of techniques ranging from conservative care to fusion. Direct repair of the defect may be utilized in young adult patients without significant disc degeneration and lumbar instability. We used minimally invasive techniques to place pars interarticularis screws with the use of an intraoperative CT scanner in three young adults, including two athletes. This technique is a modification of the original procedure in 1970 by Buck, and it offers the advantage of minimal muscle dissection and optimal screw trajectory. There were no intra- or postoperative complications. The detailed operative procedure and the postoperative course along with a brief review of pars interarticularis defect treatment are discussed.

  13. Rabies in humans and non-human in the state of Pará, Brazilian Amazon

    Directory of Open Access Journals (Sweden)

    Marcus Emanuel Barroncas Fernandes

    2013-04-01

    Full Text Available We evaluate the relationship of positive cases of rabies with the continuing expansion of livestock production, and analyse the trends of this zoonosis in human population in the state of Pará, Brazilian Amazon. The distribution of rabies cases was recorded between 1999 and 2004. Of 148 cases of rabies, 21% were in humans and 79% in non-human mammals. The rapid growth in livestock numbers seems to be associated with the increase of positive cases in bovine livestock transmitted by vampire bats. This idea is supported by positive and significant relationship of both events in time (p < 0.01, but failed when spatial distribution among regions of the state was considered. However, rabies cases tend to occur toward the northeastern of the state of Pará, where rabies cases are proportionally five times greater than other mesoregions, suggesting that increased livestock production may influence the increase of this zoonosis.

  14. Rabies in humans and non-human in the state of Pará, Brazilian Amazon

    Directory of Open Access Journals (Sweden)

    Marcus Emanuel Barroncas Fernandes

    Full Text Available We evaluate the relationship of positive cases of rabies with the continuing expansion of livestock production, and analyse the trends of this zoonosis in human population in the state of Pará, Brazilian Amazon. The distribution of rabies cases was recorded between 1999 and 2004. Of 148 cases of rabies, 21% were in humans and 79% in non-human mammals. The rapid growth in livestock numbers seems to be associated with the increase of positive cases in bovine livestock transmitted by vampire bats. This idea is supported by positive and significant relationship of both events in time (p < 0.01, but failed when spatial distribution among regions of the state was considered. However, rabies cases tend to occur toward the northeastern of the state of Pará, where rabies cases are proportionally five times greater than other mesoregions, suggesting that increased livestock production may influence the increase of this zoonosis.

  15. Désadification biologique des vins par les levures de fleur

    Directory of Open Access Journals (Sweden)

    C. LLAGUNO

    1971-03-01

    Le processus de désacidification bactérienne du vin par la fermentation malolactique est bien connu. Le vin acquiert ainsi une plus grande souplesse au goût et une stabilité biologique indispensable à sa conservation en bouteilles. Cependant, les levures Schizosaccharomyces pombe peuvent aussi fermenter l'acide malique (RIBÉREAU-GAYON et PEYNAUD, 1962. TARANTOLA et GANDINI, 1967 ont décrit des essais semi-industriels de désacidification biologique d'un moût blanc piémontais ; provoquée aussi bien par l'ensemencement de bactéries malolactiques  que de Schizosaccharomyces pombe.

  16. BOREAS TE-9 PAR and Leaf Nitrogen Data for NSA Species

    Science.gov (United States)

    Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Dang, Qinglai; Margolis, Hank; Coyea, Marie

    2000-01-01

    The Boreal Ecosystem-Atmospheric Study (BOREAS) TE-9 (Terrestrial Ecology) team collected several data sets related to chemical and photosynthetic properties of leaves in boreal forest tree species. This data set describes the relationship between photosynthetically active radiation (PAR) levels and foliage nitrogen in samples from six sites in the BOREAS Northern Study Area (NSA) collected during the three 1994 intensive field campaigns (IFCs). This information is useful for modeling the vertical distribution of carbon fixation for these different forest types in the boreal forest. The data were collected to quantify the relationship between PAR and leaf nitrogen of black spruce, jack pine, and aspen. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  17. CALiPER Application Summary Report 20. LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2012-11-01

    This report analyzes the independently tested photometric performance of 38 LED PAR38 lamps. The test results indicate substantial improvement versus earlier CALiPER testing of similar products, and performance comparable to recent data from LED Lighting Facts and ENERGY STAR. Additional testing that focuses on performance attributes beyond those covered by LM-79-08 is planned for this group of lamps, and will be presented in subsequent reports.

  18. Piqures massives par un essaim d�abeilles chez un enfant

    Directory of Open Access Journals (Sweden)

    Mohamed Adnane Berdai

    2011-10-01

    Full Text Available Les piqures multiples d�abeilles sont responsables d�envenimation severe. Nous rapportons un cas d�une attaque massive par un essaim d�abeilles chez un enfant de sept ans. Sa gravite est liee a la localisation cephalique et au nombre important des piqures qui etait d�environ 270. Ses complications etaient l�insuffisance renale, l�anemie et une conjonctivite. La prise en charge etait symptomatique avec bonne evolution clinique et biologique.

  19. Effet de l'alimentation calcique séparée sur les performances de ...

    African Journals Online (AJOL)

    SARAH

    31 janv. 2016 ... RÉSUMÉ. Object : L'étude envisagée, se propose de vérifier la réponse de la souche Lhoman Brown soumise à l'alimentation calcique séparée. Elle s'inscrit dans le contexte de la sécurité alimentaire, la lutte contre la pauvreté et les changements climatiques sous climat tropical humide. Matériels et ...

  20. Amélioration de la nutrition en Éthiopie par le truchement de la ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Amélioration de la nutrition en Éthiopie par le truchement de la sélection végétale et de la gestion des sols (FCRSAI). L'Éthiopie présente l'un des plus hauts taux de malnutrition au monde. La situation est particulièrement grave dans le sud du pays en raison de la faible productivité agricole et du régime alimentaire ...

  1. Moniliophthora roreri (Cif y Par) Evans et al. en el cultivo de cacao

    OpenAIRE

    Sánchez Mora, Fernando David; Garcés Fiallos, Felipe Rafael

    2012-01-01

    More than a century, cacao (Theobroma cacao L.) in Ecuador has been an important source of income for farmers and currency for the country, becoming one of the biggest exporters worldwide. Then, gradually lost that status due to the attack of diseases, including moniliasis caused by [Moniliophthora roreri (Cif and Par) Evans et al.]. It can cause damage of up to 80% in production. Currently there is little scientific date information on its occurrence, symptoms, etiology, epidemiology, life c...

  2. Influence des herbicides sur l'infestation par les adventices, la ...

    African Journals Online (AJOL)

    SARAH

    30 juin 2015 ... Keywords: Wheat, herbicides, weed, density, dry matter. INTRODUCTION. Une des raisons majeures de la chute des rendements des cultures céréalières comme les blés dans la zone «non chernozem» de la Russie et le reste du monde, demeure une forte infestation par différentes espèces adventices.

  3. La participation des femmes à la vie politique se traduit par des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La participation des femmes à la vie politique se traduit par des économies locales plus vigoureuses. 08 juin 2016. Image. Des femmes assistent à une réunion d'un groupe d'entraide près d'. Edgard Rodriguez - IDRC. Des femmes assistent à une ré